Gene,Gene ID,Category,PMID,Title,Year,DOI,URL,Queries,Review
ABCC11,ENSG00000121270,CTA,42745633,MRP8-Cre Transgenic Mice Are Resistant to Weight Gain and Diet-Induced Obesity Independently of Neutrophils.,2026,10.1002/eji.70271,https://pubmed.ncbi.nlm.nih.gov/42745633/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,42284988,Constitutively active MEK1 expression driven by the myeloid-selective MRP8 promoter induces epithelial hyperplasia and papilloma formation.,2026,10.1016/j.bbrc.2026.154134,https://pubmed.ncbi.nlm.nih.gov/42284988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,42334869,"The protein tyrosine phosphatase CD45 promotes PMN transepithelial migration, antimicrobial function, and colonic mucosal repair.",2026,10.1172/jci.insight.203438,https://pubmed.ncbi.nlm.nih.gov/42334869/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,42730042,"Association of Circulating and Urinary Calprotectin (S100A8/A9, MRP8/14) Levels with Type 2 Diabetes Mellitus and its Complications: A Systematic Review and Meta-analysis.",2026,,https://pubmed.ncbi.nlm.nih.gov/42730042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,40619816,Mechanism of Neutrophil p90RSK-Nrf2 Signaling Pathway in Atherosclerosis.,2025,10.4274/balkanmedj.galenos.2025.2025-4-73,https://pubmed.ncbi.nlm.nih.gov/40619816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,41493639,Inhibition of SPI1 by ADAP Regulates S100A8/A9 Signaling in Macrophages to Control the Development of Colitis.,2026,10.1007/s10753-025-02363-9,https://pubmed.ncbi.nlm.nih.gov/41493639/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,41149076,Utility of a Multimodal Biomarker Panel and Serum Proapoptotic Activity to Refine Diagnosis of Ovarian Adnexal Masses.,2025,10.3390/diseases13100342,https://pubmed.ncbi.nlm.nih.gov/41149076/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,41009771,An Emerging Paradigm for ABCC5/MRP5 Function in Human Physiology.,2025,10.3390/ijms26189211,https://pubmed.ncbi.nlm.nih.gov/41009771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,42869283,Neutrophils drive pancreatic inflammation and tissue injury but promote tissue repair in severe acute pancreatitis.,2026,10.1016/j.ajpath.2026.09.008,https://pubmed.ncbi.nlm.nih.gov/42869283/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,39543265,Interplay of human ABCC11 transporter gene variants with axillary skin microbiome functional genomics.,2024,10.1038/s41598-024-78711-w,https://pubmed.ncbi.nlm.nih.gov/39543265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,39817749,Association between the <i>ABCC11</i> gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults.,2025,10.1128/spectrum.01698-24,https://pubmed.ncbi.nlm.nih.gov/39817749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,40801133,ABCC11 Earwax Trait and Genotype Are Suitable Tools for Introductory Labs to Learn Genetics and Molecular Techniques.,2025,10.1002/bmb.70010,https://pubmed.ncbi.nlm.nih.gov/40801133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,41790423,Tissue-Resident Macrophage PIEZO1 Transduces Mechanical Stress into Inflammatory Pain in Acute Gout.,2026,10.1007/s12264-026-01592-8,https://pubmed.ncbi.nlm.nih.gov/41790423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,41343113,ABCB1 and ABCC10 polymorphisms predict sensitivity to first- and third-generation EGFR-TKIs in EGFR-mutant NSCLC.,2025,10.1007/s10637-025-01594-9,https://pubmed.ncbi.nlm.nih.gov/41343113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,38750405,"Functional characterization of variants in human ABCC11, an axillary osmidrosis risk factor.",2024,10.1007/s13577-024-01074-x,https://pubmed.ncbi.nlm.nih.gov/38750405/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,40335739,FXR protects against neonatal sepsis by enhancing the immunosuppressive function of MDSCs.,2025,10.1038/s41423-025-01289-4,https://pubmed.ncbi.nlm.nih.gov/40335739/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,39632992,The need for Cre-loci controls in conditional mouse experiments: Mrp8-cre transgene predisposes mice to antibody-induced arthritis.,2025,10.1038/s41435-024-00313-3,https://pubmed.ncbi.nlm.nih.gov/39632992/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,37701855,Sustained induction of IP-10 by MRP8/14 via the IFNβ-IRF7 axis in macrophages exaggerates lung injury in endotoxemic mice.,2023,10.1093/burnst/tkad006,https://pubmed.ncbi.nlm.nih.gov/37701855/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,37778383,Neutrophil peptidylarginine deiminase 4 is essential for detrimental age-related cardiac remodelling and dysfunction in mice.,2023,10.1098/rstb.2022.0475,https://pubmed.ncbi.nlm.nih.gov/37778383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,41226454,Human Body Malodor and Deodorants: The Present and the Future.,2025,10.3390/ijms262110415,https://pubmed.ncbi.nlm.nih.gov/41226454/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,42834697,Heliox versus trimix in closed-circuit rebreather diving: A comparative study of pulmonary and decompression stress in male divers.,2026,10.14814/phy2.71129,https://pubmed.ncbi.nlm.nih.gov/42834697/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,37376663,MRP8/14 Is a Molecular Signature Triggered by Dopamine in HIV Latent Myeloid Targets That Increases HIV Transcription and Distinguishes HIV+ Methamphetamine Users with Detectable CSF Viral Load and Brain Pathology.,2023,10.3390/v15061363,https://pubmed.ncbi.nlm.nih.gov/37376663/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,39834541,The analysis of gene co-expression network and immune infiltration revealed biomarkers between triple-negative and non-triple negative breast cancer.,2024,10.3389/fgene.2024.1505011,https://pubmed.ncbi.nlm.nih.gov/39834541/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,37637998,Exploratory study of macrophage polarization and spatial distribution in colorectal cancer liver metastasis: a pilot study.,2023,10.3389/fimmu.2023.1223864,https://pubmed.ncbi.nlm.nih.gov/37637998/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,40947715,Transcriptomic and Proteomics Analysis of a Lipid-Loaded HepaRG Model for Steatosis Reveals Altered Regulation in Lipid and Xenobiotic Metabolism.,2025,10.2174/0113892002381234250727004847,https://pubmed.ncbi.nlm.nih.gov/40947715/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,35486225,Use of MRP8/14 in clinical practice as a predictor of outcome after methotrexate withdrawal in patients with juvenile idiopathic arthritis.,2022,10.1007/s10067-022-06165-4,https://pubmed.ncbi.nlm.nih.gov/35486225/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,37773690,Activation of Toll-like receptor 4 by thyroid hormone triggers abnormal B-cell activation.,2023,10.1002/iid3.1007,https://pubmed.ncbi.nlm.nih.gov/37773690/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,35363194,Adenosine triphosphate-binding cassette subfamily C members in liver hepatocellular carcinoma: Bioinformatics-driven prognostic value.,2022,10.1097/md.0000000000028869,https://pubmed.ncbi.nlm.nih.gov/35363194/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,38672442,Utilization of Diverse Molecules as Receptors by Cry Toxin and the Promiscuous Nature of Receptor-Binding Sites Which Accounts for the Diversity.,2024,10.3390/biom14040425,https://pubmed.ncbi.nlm.nih.gov/38672442/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,39080656,Multi-omic signatures of sarcoidosis and progression in bronchoalveolar lavage cells.,2024,10.1186/s12931-024-02919-7,https://pubmed.ncbi.nlm.nih.gov/39080656/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,37944028,"Unraveling the universality of chemical fear communication: evidence from behavioral, genetic, and chemical analyses.",2023,10.1093/chemse/bjad046,https://pubmed.ncbi.nlm.nih.gov/37944028/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,37179295,IL-10 production by granulocytes promotes Staphylococcus aureus craniotomy infection.,2023,10.1186/s12974-023-02798-7,https://pubmed.ncbi.nlm.nih.gov/37179295/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,19710689,A functional ABCC11 allele is essential in the biochemical formation of human axillary odor.,2010,10.1038/jid.2009.254,https://pubmed.ncbi.nlm.nih.gov/19710689/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,19383836,"Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?",2009,10.1096/fj.09-129098,https://pubmed.ncbi.nlm.nih.gov/19383836/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,16359813,"Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system.",2006,10.1016/j.neuroscience.2005.10.025,https://pubmed.ncbi.nlm.nih.gov/16359813/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
ABCC11,ENSG00000121270,CTA,11591886,"MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer.",2001,10.1007/bf03401856,https://pubmed.ncbi.nlm.nih.gov/11591886/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC11,ENSG00000121270,CTA,11483364,"Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12.",2001,10.1016/s0378-1119(01)00572-8,https://pubmed.ncbi.nlm.nih.gov/11483364/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42747431,ATP-dependent chromatin remodelers in prostate cancer progression and therapeutic resistance.,2026,10.1210/endocr/bqag103,https://pubmed.ncbi.nlm.nih.gov/42747431/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42231419,Acyl CoA reductases useful for bioproduction of hydrocarbons.,2026,10.1186/s12934-026-03038-2,https://pubmed.ncbi.nlm.nih.gov/42231419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42087786,Optimized optogenetic anti-CRISPR for endogenous gene regulation in Drosophila.,2026,10.1093/nar/gkag244,https://pubmed.ncbi.nlm.nih.gov/42087786/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42098321,ATRA-mediated RAR-α activation attenuates acrylamide-induced testicular toxicity.,2026,10.1038/s41598-026-50168-z,https://pubmed.ncbi.nlm.nih.gov/42098321/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42550302,Olive leaf extract attenuates acrylamide-induced reproductive toxicity through reduced oxidative DNA damage and apoptosis associated with 8-OHdG and Caspase-3 in rats.,2026,10.1007/s10735-026-10923-y,https://pubmed.ncbi.nlm.nih.gov/42550302/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42717142,4-Phenylbutyric acid alleviates acrylamide-induced sexual behavioral deficits and testicular damage in male Wistar rats: modulation of ER-stress associated signaling.,2026,10.1007/s10735-026-10967-0,https://pubmed.ncbi.nlm.nih.gov/42717142/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42113595,ATAC-seq of low-input and cryopreserved primordial germ cells reveals functional enhancers.,2026,10.1242/dev.205214,https://pubmed.ncbi.nlm.nih.gov/42113595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42653455,Effects of Iloprost on TRPM7-Mediated Apoptosis and Oxidative Stress in an Experimental Testicular Torsion-Detorsion Model.,2026,10.3390/ijms27167454,https://pubmed.ncbi.nlm.nih.gov/42653455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,41906094,The landscape of regulatory element evolution in a C4 perennial grass.,2026,10.1186/s12864-026-12785-w,https://pubmed.ncbi.nlm.nih.gov/41906094/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,41645293,Comparative evaluation of ACRS and PRP on inflammation and lesion activity in a rat model of peritoneal endometriosis.,2026,10.1186/s40001-026-03969-x,https://pubmed.ncbi.nlm.nih.gov/41645293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42914891,Comparative effects of autologous cytokine-rich serum and platelet-rich fibrin on bone regeneration in a rabbit calvarial defect model.,2026,10.1016/j.tice.2026.104053,https://pubmed.ncbi.nlm.nih.gov/42914891/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42832179,Comparative Therapeutic Effects of Cytokine-Rich Serum and Platelet-Rich Plasma in a Rat Model of Ovarian Ischemia-Reperfusion Injury.,2026,10.1007/s43032-026-02223-3,https://pubmed.ncbi.nlm.nih.gov/42832179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,41802267,Circadian oscillations in chromatin accessibility systematically orchestrate rhythmic gene transcription in soybean.,2026,10.1093/plcell/koag063,https://pubmed.ncbi.nlm.nih.gov/41802267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42883950,"Comparative Effects of Acrolein and Glyoxal on Redox Homeostasis, Antioxidant Defense and Membrane Properties in Human Peripheral Blood Mononuclear Cells: An In Vitro Study.",2026,10.3390/ijms27198706,https://pubmed.ncbi.nlm.nih.gov/42883950/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42815050,"Effects of in ovo acrylamide injection on bone mineral composition and morphometric, geometric and mechanical parameters of femur and tibia bone of newly hatched chickens.",2026,10.1016/j.psj.2026.107816,https://pubmed.ncbi.nlm.nih.gov/42815050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,41285681,From duplication to divergence: Single-cell insights into transcriptional and cis-regulatory landscapes in soybean.,2025,10.1093/plcell/koaf279,https://pubmed.ncbi.nlm.nih.gov/41285681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42399749,Genome-wide characterization of the accessible chromatin regions in chickpea.,2026,10.1186/s12864-026-13136-5,https://pubmed.ncbi.nlm.nih.gov/42399749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42774971,"The epidemiological landscape of canine tumors in central Italy: animal cancer registry insights, distribution patterns, and incidence estimates.",2026,10.3389/fvets.2026.1919722,https://pubmed.ncbi.nlm.nih.gov/42774971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42393511,Integrative ATAC-Seq and RNA-Seq analysis identifies key genes for intramuscular fat content in Laiwu pigs.,2026,10.1186/s12864-026-13135-6,https://pubmed.ncbi.nlm.nih.gov/42393511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42731211,Changes in the chick liver structure and blood plasma biochemical properties following in ovo administration of acrylamide.,2026,10.1016/j.psj.2026.107580,https://pubmed.ncbi.nlm.nih.gov/42731211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42287710,Development of acute-to-chronic ratios to support ecotoxicity prediction for surfactants.,2026,10.1093/etojnl/vgag162,https://pubmed.ncbi.nlm.nih.gov/42287710/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42554846,The applicability of acute-to-chronic ratios and in silico tools in estimating chronic aquatic toxicity of ingredients in cosmetics and personal care products.,2026,10.1093/inteam/vjag126,https://pubmed.ncbi.nlm.nih.gov/42554846/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,41568987,Mechanistic Acute-to-Chronic Extrapolation through Sediment Toxicokinetic-Toxicodynamic Modeling.,2026,10.1021/acs.est.5c13691,https://pubmed.ncbi.nlm.nih.gov/41568987/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42555864,Trapping effect and mechanism of pomelo peel flavonoids on acrolein and DPPH radical scavenging and cytotoxic activities of the adducts.,2026,10.1080/14786419.2026.2711432,https://pubmed.ncbi.nlm.nih.gov/42555864/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,41840328,"Efficacy and Safety of Obexelimab to Treat IgG4-Related Disease: Protocol for a Global, Randomized, Placebo-Controlled Trial.",2026,10.1007/s40744-026-00835-4,https://pubmed.ncbi.nlm.nih.gov/41840328/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42916357,Probiotics-Driven Type I Photosensitizer for Tumor-Targeted Fluorescence Imaging and Photodynamic Immunotherapy.,2026,10.1021/acs.analchem.6c04528,https://pubmed.ncbi.nlm.nih.gov/42916357/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,41501497,CD19 CAR-T cells for treatment-refractory autoimmune diseases: the phase 1/2 CASTLE basket trial.,2026,10.1038/s41591-025-04185-6,https://pubmed.ncbi.nlm.nih.gov/41501497/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42790284,Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Pathway in High-Risk Lymphocytic Acute Myocarditis.,2026,10.1016/j.jacadv.2026.103254,https://pubmed.ncbi.nlm.nih.gov/42790284/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42380590,In vitro development of the Autonomous Colonoscope Robot System (ACRS) for fully automated colonoscope insertion.,2026,10.1038/s43856-026-01747-8,https://pubmed.ncbi.nlm.nih.gov/42380590/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42511588,Acyclic Retinoid Attenuates STAT3 Signaling and Reduces In Vitro Growth of A375-Derived Dabrafenib Plus Trametinib-Resistant Melanoma Cells.,2026,10.3390/ijms27146245,https://pubmed.ncbi.nlm.nih.gov/42511588/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42251428,"Kidney abnormalities in young people living with HIV on dolutegravir-based regimens in Kampala, Uganda.",2026,10.1186/s12981-026-00893-2,https://pubmed.ncbi.nlm.nih.gov/42251428/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42898581,Rapid identification of acrolein scavengers from <i>Anoectochilus roxburghii</i> and evaluation of their representative antiglycation and antioxidant activities.,2026,10.1016/j.fochx.2026.104585,https://pubmed.ncbi.nlm.nih.gov/42898581/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42080294,EnAcrPred: A robust ensemble machine learning framework for identifying anti-CRISPR proteins.,2026,10.1002/pro.70559,https://pubmed.ncbi.nlm.nih.gov/42080294/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42158870,Revisiting B-cell targeted therapies in rheumatoid arthritis: from paradoxical biology to deep immune reset.,2026,10.3389/fimmu.2026.1809668,https://pubmed.ncbi.nlm.nih.gov/42158870/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42614283,Case Report: Pembrolizumab-associated seronegative sicca syndrome during continued immunotherapy and after drug withdrawal in metastatic urothelial carcinoma.,2026,10.3389/fmed.2026.1906210,https://pubmed.ncbi.nlm.nih.gov/42614283/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,40758882,Protective antigen-mediated delivery of an anti-CRISPR protein for precision genome editing.,2025,10.1073/pnas.2426960122,https://pubmed.ncbi.nlm.nih.gov/40758882/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACR,ENSG00000100312,CTA,42294825,"Immunogenicity, Safety, and Determinants of Recombinant Zoster Vaccine Response in Idiopathic Inflammatory Myopathies: A Phase 4 Randomized Trial.",2026,10.1002/acr.80103,https://pubmed.ncbi.nlm.nih.gov/42294825/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,41629949,The HKDC1-ASS1-ACSBG2 axis reprograms lipid metabolism to drive therapeutic resistance in hepatocellular carcinoma.,2026,10.1186/s12967-026-07779-x,https://pubmed.ncbi.nlm.nih.gov/41629949/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,39846195,Multi-omics analysis and experimental verification reveal testicular fatty acid metabolism disorder in non-obstructive azoospermia.,2025,10.24272/j.issn.2095-8137.2024.223,https://pubmed.ncbi.nlm.nih.gov/39846195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,42187729,Identification of Reproductive Trait-Associated Loci and Candidate Genes in Commercial Pigs via 50K SNP Genotyping and Genome-Wide Association Study.,2026,10.3390/biology15100766,https://pubmed.ncbi.nlm.nih.gov/42187729/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,40362129,Transcriptome Analysis Reveals the Molecular Mechanism Involved in Carotenoid Absorption and Metabolism in the Ridgetail White Prawn <i>Exopalaemon carinicauda</i>.,2025,10.3390/ani15091314,https://pubmed.ncbi.nlm.nih.gov/40362129/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,39825440,Integrative bioinformatics and machine learning approach unveils potential biomarkers linking coronary atherosclerosis and fatty acid metabolism-associated gene.,2025,10.1186/s13019-024-03199-4,https://pubmed.ncbi.nlm.nih.gov/39825440/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,42741484,Integrated transcriptomics and metabolomics reveal suppression of the PPAR α/γ pathway linking purine metabolism disorder to high-protein diet-induced hyperuricemia in goslings.,2026,10.1016/j.aninu.2026.03.011,https://pubmed.ncbi.nlm.nih.gov/42741484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,38528586,Cortical lipid metabolic pathway alteration of early Alzheimer's disease and candidate drugs screen.,2024,10.1186/s40001-024-01730-w,https://pubmed.ncbi.nlm.nih.gov/38528586/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,39857286,"Biochemical, Histological, and Multi-Omics Analyses Reveal the Molecular and Metabolic Mechanisms of Cold Stress Response in the Chinese Soft-Shelled Turtle (Pelodiscus sinensis).",2025,10.3390/biology14010055,https://pubmed.ncbi.nlm.nih.gov/39857286/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,40028755,"Changes in the Expression of Some Genes With Metabolic, VLDL and Antioxidative Effects After the Addition of Essential Oil Mixture to Drinking Water in the Liver of Domestic Geese (Anser anser Domesticus).",2025,10.1002/vms3.70285,https://pubmed.ncbi.nlm.nih.gov/40028755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,37936076,Broodstock nutritional programming differentially affects the hepatic transcriptome and genome-wide DNA methylome of farmed gilthead sea bream (Sparus aurata) depending on genetic background.,2023,10.1186/s12864-023-09759-7,https://pubmed.ncbi.nlm.nih.gov/37936076/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,38998051,Transcriptome Analysis Reveals the Potential Key Genes in Nutritional Deposition in the Common Carp (<i>Cyprinus carpio</i>).,2024,10.3390/ani14131939,https://pubmed.ncbi.nlm.nih.gov/38998051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,40037069,"Comparative analysis of the heart histological structure, metabolic enzyme activities and transcriptome profiles of juvenile and adult yellowfin tuna (Thunnus albacares) in the South China Sea.",2025,10.1016/j.cbd.2025.101460,https://pubmed.ncbi.nlm.nih.gov/40037069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,40071213,Effects and potential pathways of goose astrovirus infection on gosling hepatic lipid metabolism.,2025,10.3389/fmicb.2025.1531373,https://pubmed.ncbi.nlm.nih.gov/40071213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,34567076,Time Course Transcriptomic Study Reveals the Gene Regulation During Liver Development and the Correlation With Abdominal Fat Weight in Chicken.,2021,10.3389/fgene.2021.723519,https://pubmed.ncbi.nlm.nih.gov/34567076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,33398680,Effects of miR-125b-5p on Preadipocyte Proliferation and Differentiation in Chicken.,2021,10.1007/s11033-020-06080-4,https://pubmed.ncbi.nlm.nih.gov/33398680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,37641844,Comparative analysis of liver transcriptome reveals adaptive responses to hypoxia environmental condition in Tibetan chicken.,2024,10.5713/ab.23.0126,https://pubmed.ncbi.nlm.nih.gov/37641844/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,36089220,"Transcriptomics provides insights into toxicological effects and molecular mechanisms associated with the exposure of Chinese mitten crab, Eriocheir sinensis, to dioxin.",2023,10.1016/j.dci.2022.104540,https://pubmed.ncbi.nlm.nih.gov/36089220/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,37893980,The Identification of Functional Genes Affecting Fat-Related Meat Traits in Meat-Type Pigeons Using Double-Digest Restriction-Associated DNA Sequencing and Molecular Docking Analysis.,2023,10.3390/ani13203256,https://pubmed.ncbi.nlm.nih.gov/37893980/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,36685859,Whole-genome resequencing reveals genetic diversity and selection characteristics of dairy goat.,2022,10.3389/fgene.2022.1044017,https://pubmed.ncbi.nlm.nih.gov/36685859/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,30150666,Transcriptional shifts account for divergent resource allocation in feed efficient broiler chickens.,2018,10.1038/s41598-018-31072-7,https://pubmed.ncbi.nlm.nih.gov/30150666/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,31138106,Determination of genetic associations between indels in 11 candidate genes and milk composition traits in Chinese Holstein population.,2019,10.1186/s12863-019-0751-y,https://pubmed.ncbi.nlm.nih.gov/31138106/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,28911249,Transcriptome analysis reveals the molecular mechanism of hepatic fat metabolism disorder caused by Muscovy duck reovirus infection.,2018,10.1080/03079457.2017.1380294,https://pubmed.ncbi.nlm.nih.gov/28911249/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,16762313,A novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis.,2006,10.1016/j.abb.2006.04.013,https://pubmed.ncbi.nlm.nih.gov/16762313/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,16371355,The second member of the human and murine bubblegum family is a testis- and brainstem-specific acyl-CoA synthetase.,2006,10.1074/jbc.m511558200,https://pubmed.ncbi.nlm.nih.gov/16371355/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSBG2,ENSG00000130377,CTA,15685348,Identification and characterization of the BGR-like gene with a potential role in human testicular development/spermatogenesis.,2005,10.1111/j.1745-7262.2005.00014.x,https://pubmed.ncbi.nlm.nih.gov/15685348/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,42538867,"Comparative Analysis of ACTL7A Expression, Localization, and Sperm Functional Parameters in Fertile and Infertile Men: A Case-Control Study.",2026,10.22074/cellj.2026.2078738.1974,https://pubmed.ncbi.nlm.nih.gov/42538867/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,42592758,Oxidative Stress-Associated Alterations in Sperm ACTL7A Expression and Function in Men With Varicocele.,2026,10.1155/omcl/1776251,https://pubmed.ncbi.nlm.nih.gov/42592758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,41169243,Perinuclear theca protein FNDC8 interacts with CCIN and ACTL7A to ensure proper sperm head shaping during spermiogenesis.,2025,10.24272/j.issn.2095-8137.2025.060,https://pubmed.ncbi.nlm.nih.gov/41169243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,42487003,Reduced and Mislocalized ACTL7A in Globozoospermia: Implications for Sperm Chromatin Integrity and Infertility.,2026,10.1007/s43032-026-02159-8,https://pubmed.ncbi.nlm.nih.gov/42487003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,42330090,Pathogenic variants in ACTRT3 lead to male infertility characterized by fertilization defects.,2026,10.1093/humrep/deag097,https://pubmed.ncbi.nlm.nih.gov/42330090/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,39411542,High rate of detected variants in male <i>PLCZ1</i> and <i>ACTL7A</i> genes causing failed fertilization after ICSI.,2024,10.1093/hropen/hoae057,https://pubmed.ncbi.nlm.nih.gov/39411542/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,42039144,Decoding coronary artery calcification: metabolic reprogramming features and a promising circulating biomarker PXDN.,2026,10.3389/fcell.2026.1714146,https://pubmed.ncbi.nlm.nih.gov/42039144/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,37667331,Loss of ACTL7A causes small head sperm by defective acrosome-acroplaxome-manchette complex.,2023,10.1186/s12958-023-01130-5,https://pubmed.ncbi.nlm.nih.gov/37667331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,36734600,"Testis-specific actin-like 7A (ACTL7A) is an indispensable protein for subacrosomal-associated F-actin formation, acrosomal anchoring, and male fertility.",2023,10.1093/molehr/gaad005,https://pubmed.ncbi.nlm.nih.gov/36734600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,41613942,Exploring the effect of skim milk on the membrane stability of frozen-thawed Inner Mongolia cashmere goat sperm based on proteomics.,2025,10.3389/fcell.2025.1701830,https://pubmed.ncbi.nlm.nih.gov/41613942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,40968718,Novel mutations in FSIP2 cause male infertility through multiple morphological abnormalities of the sperm flagella.,2026,10.4103/aja202542,https://pubmed.ncbi.nlm.nih.gov/40968718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,37991128,Novel ACTL7A variants in males lead to fertilization failure and male infertility.,2025,10.1111/andr.13553,https://pubmed.ncbi.nlm.nih.gov/37991128/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,38929397,Inhibition of Prolactin Affects Epididymal Morphology by Decreasing the Secretion of Estradiol in Cashmere Bucks.,2024,10.3390/ani14121778,https://pubmed.ncbi.nlm.nih.gov/38929397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,41668650,Actin-related protein T3 is required for acrosome biogenesis and sperm function in mice.,2026,10.1242/dev.205283,https://pubmed.ncbi.nlm.nih.gov/41668650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,37083698,Whole transcriptome sequencing reveals core genes related to spermatogenesis in Bactrian camels.,2023,10.1093/jas/skad115,https://pubmed.ncbi.nlm.nih.gov/37083698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,35532568,Sperm-specific protein ACTL7A as a biomarker for fertilization outcomes of assisted reproductive technology.,2022,10.4103/aja2021111,https://pubmed.ncbi.nlm.nih.gov/35532568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,36306217,Testis-specific serine kinase 3 is required for sperm morphogenesis and male fertility.,2023,10.1111/andr.13314,https://pubmed.ncbi.nlm.nih.gov/36306217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,37286336,A recessive ACTL7A founder variant leads to male infertility due to acrosome detachment in Pakistani Pashtuns.,2023,10.1111/cge.14383,https://pubmed.ncbi.nlm.nih.gov/37286336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,38963606,Homozygous ACTL9 mutations cause irregular mitochondrial sheath arrangement and abnormal flagellum assembly in spermatozoa and male infertility.,2024,10.1007/s10815-024-03171-0,https://pubmed.ncbi.nlm.nih.gov/38963606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,34727571,Novel bi-allelic variants in ACTL7A are associated with male infertility and total fertilization failure.,2021,10.1093/humrep/deab228,https://pubmed.ncbi.nlm.nih.gov/34727571/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,38414365,Deletion of ACTRT1 is associated with male infertility as sperm acrosomal ultrastructural defects and fertilization failure in human.,2024,10.1093/humrep/deae031,https://pubmed.ncbi.nlm.nih.gov/38414365/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,34172998,Loss of SPACA1 function causes autosomal recessive globozoospermia by damaging the acrosome-acroplaxome complex.,2021,10.1093/humrep/deab144,https://pubmed.ncbi.nlm.nih.gov/34172998/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,37004249,ACROSIN deficiency causes total fertilization failure in humans by preventing the sperm from penetrating the zona pellucida.,2023,10.1093/humrep/dead059,https://pubmed.ncbi.nlm.nih.gov/37004249/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7A,ENSG00000187003,CTA,10373328,"Cloning, mapping, and expression of two novel actin genes, actin-like-7A (ACTL7A) and actin-like-7B (ACTL7B), from the familial dysautonomia candidate region on 9q31.",1999,10.1006/geno.1999.5848,https://pubmed.ncbi.nlm.nih.gov/10373328/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
ACTL7B,ENSG00000148156,CTA,37800308,Actl7b deficiency leads to mislocalization of LC8 type dynein light chains and disruption of murine spermatogenesis.,2023,10.1242/dev.201593,https://pubmed.ncbi.nlm.nih.gov/37800308/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7B,ENSG00000148156,CTA,36617158,Actin-related protein ACTL7B ablation leads to OAT with multiple morphological abnormalities of the flagellum and male infertility in mice†.,2023,10.1093/biolre/ioad001,https://pubmed.ncbi.nlm.nih.gov/36617158/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7B,ENSG00000148156,CTA,35914715,Comparative proteomics analysis of human FFPE testicular tissues reveals new candidate biomarkers for distinction among azoospermia types and subtypes.,2022,10.1016/j.jprot.2022.104686,https://pubmed.ncbi.nlm.nih.gov/35914715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7B,ENSG00000148156,CTA,32973212,Novel targets identified by integrated proteomic and phosphoproteomic analysis in spermatogenesis of swamp buffalo (Bubalus bubalis).,2020,10.1038/s41598-020-72353-4,https://pubmed.ncbi.nlm.nih.gov/32973212/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7B,ENSG00000148156,CTA,31310081,Genetic Polymorphisms within The Intronless ACTL7A and ACTL7B Genes Encoding Spermatogenesis-Specific Actin-Like Proteins in Japanese Males.,2019,10.22074/ijfs.2019.5702,https://pubmed.ncbi.nlm.nih.gov/31310081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7B,ENSG00000148156,CTA,34002409,Identification of genes associated with litter size combining genomic approaches in Luzhong mutton sheep.,2021,10.1111/age.13078,https://pubmed.ncbi.nlm.nih.gov/34002409/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7B,ENSG00000148156,CTA,27878761,Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans.,2017,10.1007/s12035-016-0282-8,https://pubmed.ncbi.nlm.nih.gov/27878761/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7B,ENSG00000148156,CTA,12907721,"Methylation of CpG dinucleotides in the open reading frame of a testicular germ cell-specific intronless gene, Tact1/Actl7b, represses its expression in somatic cells.",2003,10.1093/nar/gkg670,https://pubmed.ncbi.nlm.nih.gov/12907721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7B,ENSG00000148156,CTA,10373328,"Cloning, mapping, and expression of two novel actin genes, actin-like-7A (ACTL7A) and actin-like-7B (ACTL7B), from the familial dysautonomia candidate region on 9q31.",1999,10.1006/geno.1999.5848,https://pubmed.ncbi.nlm.nih.gov/10373328/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL7B,ENSG00000148156,CTA,12840782,African American hypertensive nephropathy maps to a new locus on chromosome 9q31-q32.,2003,10.1086/377184,https://pubmed.ncbi.nlm.nih.gov/12840782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,41129177,Multiomic Selection of Cancer-Testis Antigens as Precision Immuno-oncologic Targets in Head and Neck Cancer.,2025,10.1001/jamaoto.2025.3563,https://pubmed.ncbi.nlm.nih.gov/41129177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,41621692,Momordin Ic suppresses breast cancer growth by targeting ACTL8‑dependent glutamine metabolism and PI3K/AKT/mTOR-MYC.,2026,10.1016/j.bcp.2026.117761,https://pubmed.ncbi.nlm.nih.gov/41621692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,41670819,Establishment of insulin resistance-related ten-gene signature in endometrial cancer and identification of ACTL8 as a prognostic and immunological biomarker.,2026,10.1007/s12094-026-04230-x,https://pubmed.ncbi.nlm.nih.gov/41670819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,39322809,ACTL8 Promotes the Progression of Gastric Cancer Through PI3K/AKT/mTOR Signaling Pathway.,2024,10.1007/s10620-024-08649-6,https://pubmed.ncbi.nlm.nih.gov/39322809/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,40595063,Identification of clusters related to programmed cell death and potential prognostic biomarkers for immunotherapy response in endometrial cancer.,2025,10.1038/s41598-025-06672-9,https://pubmed.ncbi.nlm.nih.gov/40595063/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,39281318,Transcriptome-based identification of key actin-binding proteins associated with high metastatic potential in breast cancer.,2024,10.3389/fmolb.2024.1440276,https://pubmed.ncbi.nlm.nih.gov/39281318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,33437360,"Expression profile of ACTL8, CTCFL, OIP5 and XAGE3 in glioma and their prognostic significance: a retrospective clinical study.",2020,,https://pubmed.ncbi.nlm.nih.gov/33437360/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,40539460,Comprehensive <i>in‑silico</i> molecular analysis of early‑onset gastric cancer identifies novel genes implicated in disease characterization and progression (Review).,2025,10.3892/or.2025.8931,https://pubmed.ncbi.nlm.nih.gov/40539460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,35051678,"Actin-like protein 8, a member of cancer/testis antigens, supports the aggressive development of oral squamous cell carcinoma cells via activating cell cycle signaling.",2022,10.1016/j.tice.2021.101708,https://pubmed.ncbi.nlm.nih.gov/35051678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,39857819,Identification of Hepatocellular Carcinoma Subtypes Based on Global Gene Expression Profiling to Predict the Prognosis and Potential Therapeutic Drugs.,2025,10.3390/biomedicines13010236,https://pubmed.ncbi.nlm.nih.gov/39857819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,40320501,Synergistic bioinformatics and sophisticated machine learning unveil ferroptosis-driven regulatory pathways and immunotherapy potential in breast carcinoma.,2025,10.1007/s12672-025-02393-7,https://pubmed.ncbi.nlm.nih.gov/40320501/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,33883901,Actin-Like Protein 8 Promotes the Progression of Triple-Negative Breast Cancer via Activating PI3K/AKT/mTOR Pathway.,2021,10.2147/ott.s291403,https://pubmed.ncbi.nlm.nih.gov/33883901/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,35574342,"Cancer/Testis Antigens as Biomarker and Target for the Diagnosis, Prognosis, and Therapy of Lung Cancer.",2022,10.3389/fonc.2022.864159,https://pubmed.ncbi.nlm.nih.gov/35574342/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,30535476,High expression of ACTL8 is poor prognosis and accelerates cell progression in head and neck squamous cell carcinoma.,2019,10.3892/mmr.2018.9716,https://pubmed.ncbi.nlm.nih.gov/30535476/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,31962007,"Actin-like protein 8 promotes cell proliferation, colony-formation, proangiogenesis, migration and invasion in lung adenocarcinoma cells.",2020,10.1111/1759-7714.13247,https://pubmed.ncbi.nlm.nih.gov/31962007/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,35116946,"Knockdown of actin-like 8 inhibits cell proliferation by regulating FOXM1, STMN1, PLK1, and BIRC5 in lung adenocarcinoma A549 cells.",2019,10.21037/tcr.2019.09.33,https://pubmed.ncbi.nlm.nih.gov/35116946/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,31810299,Differential Expression of ACTL8 Gene and Association Study of Its Variations with Growth Traits in Chinese Cattle.,2019,10.3390/ani9121068,https://pubmed.ncbi.nlm.nih.gov/31810299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,31069014,Large-scale in-silico identification of a tumor-specific antigen pool for targeted immunotherapy in triple-negative breast cancer.,2019,10.18632/oncotarget.26808,https://pubmed.ncbi.nlm.nih.gov/31069014/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,30881029,Upregulated expression of ACTL8 contributes to invasion and metastasis and indicates poor prognosis in colorectal cancer.,2019,10.2147/ott.s185858,https://pubmed.ncbi.nlm.nih.gov/30881029/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,32125225,Actin‑like protein 8 executes a promoting function in the malignant progression of endometrial cancer: identification of a promising biomarker.,2020,10.1080/09168451.2020.1736508,https://pubmed.ncbi.nlm.nih.gov/32125225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,23592437,Expression of cancer/testis antigens is correlated with improved survival in glioblastoma.,2013,10.18632/oncotarget.950,https://pubmed.ncbi.nlm.nih.gov/23592437/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,24764584,Tumor subtype-specific cancer-testis antigens as potential biomarkers and immunotherapeutic targets for cancers.,2014,10.1158/2326-6066.cir-13-0088,https://pubmed.ncbi.nlm.nih.gov/24764584/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL8,ENSG00000117148,CTA,15905330,Identification of cancer/testis-antigen genes by massively parallel signature sequencing.,2005,10.1073/pnas.0502583102,https://pubmed.ncbi.nlm.nih.gov/15905330/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT1,ENSG00000123165,CTA,41913266,Testis-specific lncRNA Teshl regulates acrosome biogenesis to maintain sperm structure and function.,2026,10.1186/s13578-026-01563-6,https://pubmed.ncbi.nlm.nih.gov/41913266/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT1,ENSG00000123165,CTA,41465095,"A Novel Variant of the <i>ACTRT1</i> Gene Is Potentially Associated with Oligoasthenoteratozoospermia, Acrosome Detachment, and Fertilization Failure.",2025,10.3390/genes16121422,https://pubmed.ncbi.nlm.nih.gov/41465095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT1,ENSG00000123165,CTA,38414365,Deletion of ACTRT1 is associated with male infertility as sperm acrosomal ultrastructural defects and fertilization failure in human.,2024,10.1093/humrep/deae031,https://pubmed.ncbi.nlm.nih.gov/38414365/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT1,ENSG00000123165,CTA,41668650,Actin-related protein T3 is required for acrosome biogenesis and sperm function in mice.,2026,10.1242/dev.205283,https://pubmed.ncbi.nlm.nih.gov/41668650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT1,ENSG00000123165,CTA,34422805,Pathogenic Variants in ACTRT1 Cause Acephalic Spermatozoa Syndrome.,2021,10.3389/fcell.2021.676246,https://pubmed.ncbi.nlm.nih.gov/34422805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT1,ENSG00000123165,CTA,39267058,Whole exome sequencing analysis of 167 men with primary infertility.,2024,10.1186/s12920-024-02005-3,https://pubmed.ncbi.nlm.nih.gov/39267058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT1,ENSG00000123165,CTA,38614076,Toward clinical exomes in diagnostics and management of male infertility.,2024,10.1016/j.ajhg.2024.03.013,https://pubmed.ncbi.nlm.nih.gov/38614076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT1,ENSG00000123165,CTA,36355490,The Expression Patterns of Human Cancer-Testis Genes Are Induced through Epigenetic Drugs in Colon Cancer Cells.,2022,10.3390/ph15111319,https://pubmed.ncbi.nlm.nih.gov/36355490/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT1,ENSG00000123165,CTA,35616329,Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice.,2022,10.1242/dev.200489,https://pubmed.ncbi.nlm.nih.gov/35616329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT1,ENSG00000123165,CTA,33972689,ARP-T1-associated Bazex-Dupré-Christol syndrome is an inherited basal cell cancer with ciliary defects characteristic of ciliopathies.,2021,10.1038/s42003-021-02054-9,https://pubmed.ncbi.nlm.nih.gov/33972689/,normal,Discussed in explicit gene adjudication; see its review depth and limitations
ACTRT1,ENSG00000123165,CTA,38872096,Silencing immune-infiltrating biomarker CCDC80 inhibits malignant characterization and tumor formation in gastric cancer.,2024,10.1186/s12885-024-12451-y,https://pubmed.ncbi.nlm.nih.gov/38872096/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT1,ENSG00000123165,CTA,35986704,Germline intergenic duplications at Xq26.1 underlie Bazex-Dupré-Christol basal cell carcinoma susceptibility syndrome.,2022,10.1111/bjd.21842,https://pubmed.ncbi.nlm.nih.gov/35986704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT1,ENSG00000123165,CTA,28869610,Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas.,2017,10.1038/nm.4368,https://pubmed.ncbi.nlm.nih.gov/28869610/,annotation citations | normal,Discussed in explicit gene adjudication; see its review depth and limitations
ADAD1,ENSG00000164113,CTA,41411337,Contrasting effects of DNA demethylation on cancer-germline gene expression in breast cancer and leukemia cells.,2025,10.1371/journal.pone.0339460,https://pubmed.ncbi.nlm.nih.gov/41411337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,39208330,"Differential expression and regulation of ADAD1, DMRTC2, PRSS54, SYCE1, SYCP1, TEX101, TEX48, and TMPRSS12 gene profiles in colon cancer tissues and their in vitro response to epigenetic drugs.",2024,10.1371/journal.pone.0307724,https://pubmed.ncbi.nlm.nih.gov/39208330/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,41665764,"Machine learning, whole-transcriptome and integrative omics analysis reveals key regulatory networks governing human spermatogonial stem cells.",2026,10.1007/s10238-026-02074-x,https://pubmed.ncbi.nlm.nih.gov/41665764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,37399121,ADAD1 is required for normal translation of nuclear pore and transport protein transcripts in spermatids of Mus musculus†.,2023,10.1093/biolre/ioad069,https://pubmed.ncbi.nlm.nih.gov/37399121/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,37552671,The RNA-binding protein Adad1 is necessary for germ cell maintenance and meiosis in zebrafish.,2023,10.1371/journal.pgen.1010589,https://pubmed.ncbi.nlm.nih.gov/37552671/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,36708028,Population-based genetic analysis in infertile men reveals novel mutations of ADAD family members in patients with impaired spermatogenesis.,2023,10.1093/hmg/ddad012,https://pubmed.ncbi.nlm.nih.gov/36708028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,32665638,"ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility.",2020,10.1038/s41598-020-67834-5,https://pubmed.ncbi.nlm.nih.gov/32665638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,39161926,Characterization of RNA Processing Genes in Colon Cancer for Predicting Clinical Outcomes.,2024,10.1177/11772719241258642,https://pubmed.ncbi.nlm.nih.gov/39161926/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,37644531,Malakoplakia with aberrant ALK expression by immunohistochemistry: a case report.,2023,10.1186/s13000-023-01383-z,https://pubmed.ncbi.nlm.nih.gov/37644531/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,35173218,Using publicly available transcriptomic data to identify mechanistic and diagnostic biomarkers in azoospermia and overall male infertility.,2022,10.1038/s41598-022-06476-1,https://pubmed.ncbi.nlm.nih.gov/35173218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,33976924,Gene and histomorphology alteration analysis in spermatogenesis arrest mouse model: a probable novel approach for infertility.,2021,10.5173/ceju.2020.0175,https://pubmed.ncbi.nlm.nih.gov/33976924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,34903054,Inductive Production of the Iron-Chelating 2-Pyridones Benefits the Producing Fungus To Compete for Diverse Niches.,2021,10.1128/mbio.03279-21,https://pubmed.ncbi.nlm.nih.gov/34903054/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,37370521,"Evaluation of the Genetic Diversity, Population Structure and Selection Signatures of Three Native Chinese Pig Populations.",2023,10.3390/ani13122010,https://pubmed.ncbi.nlm.nih.gov/37370521/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,24066034,Identification of male gametogenesis expressed genes from the scallop Nodipecten subnodosus by suppressive subtraction hybridization and pyrosequencing.,2013,10.1371/journal.pone.0073176,https://pubmed.ncbi.nlm.nih.gov/24066034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,26917059,Association of rs6822844 within the KIAA1109/TENR/IL2/IL21 locus with rheumatoid arthritis in the Algerian population.,2016,10.1111/tan.12757,https://pubmed.ncbi.nlm.nih.gov/26917059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,32571262,Immune-related genes in tumor-specific CD4+ and CD8+ T cells in colon cancer.,2020,10.1186/s12885-020-07075-x,https://pubmed.ncbi.nlm.nih.gov/32571262/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,25973848,Differential Genes Expression between Fertile and Infertile Spermatozoa Revealed by Transcriptome Analysis.,2015,10.1371/journal.pone.0127007,https://pubmed.ncbi.nlm.nih.gov/25973848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,27911851,Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration.,2016,10.18632/oncotarget.10546,https://pubmed.ncbi.nlm.nih.gov/27911851/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,15649457,Disruption of murine Tenr results in teratospermia and male infertility.,2005,10.1016/j.ydbio.2004.10.009,https://pubmed.ncbi.nlm.nih.gov/15649457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,37248783,Rod-to-sphere elemental reconstruction of biocompatible Ag2Te-Ag4.53-Te3 nanoparticles for triple negative breast cancer photo-nano-therapy.,2023,10.1039/d3tb00297g,https://pubmed.ncbi.nlm.nih.gov/37248783/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,28145159,Non-HLA gene polymorphisms in juvenile idiopathic arthritis: associations with disease outcome.,2017,10.1080/03009742.2016.1238959,https://pubmed.ncbi.nlm.nih.gov/28145159/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,20553587,Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance.,2010,10.1186/ar3053,https://pubmed.ncbi.nlm.nih.gov/20553587/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,22654555,The genetic basis of graves' disease.,2011,10.2174/138920211798120772,https://pubmed.ncbi.nlm.nih.gov/22654555/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,17558408,A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.,2007,10.1038/ng2058,https://pubmed.ncbi.nlm.nih.gov/17558408/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD1,ENSG00000164113,CTA,20722033,"The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.",2010,10.1002/art.27688,https://pubmed.ncbi.nlm.nih.gov/20722033/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM18,ENSG00000168619,CTA,42612345,Mineral-driven molecular signatures of energy metabolism underpin sperm motility in buffalo.,2026,10.1016/j.anireprosci.2026.108307,https://pubmed.ncbi.nlm.nih.gov/42612345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM18,ENSG00000168619,CTA,38761174,Identification of a novel matrix metalloproteinases-related prognostic signature in hepatocellular carcinoma.,2024,10.18632/aging.205832,https://pubmed.ncbi.nlm.nih.gov/38761174/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM18,ENSG00000168619,CTA,33520806,Mechanistic dissection of diabetic retinopathy using the protein-metabolite interactome.,2020,10.1007/s40200-020-00570-9,https://pubmed.ncbi.nlm.nih.gov/33520806/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM18,ENSG00000168619,CTA,30464627,A novel 12-marker panel of cancer-associated fibroblasts involved in progression of hepatocellular carcinoma.,2018,10.2147/cmar.s176152,https://pubmed.ncbi.nlm.nih.gov/30464627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM18,ENSG00000168619,CTA,23816990,The Rhesus macaque (Macaca mulatta) sperm proteome.,2013,10.1074/mcp.m112.026476,https://pubmed.ncbi.nlm.nih.gov/23816990/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM18,ENSG00000168619,CTA,23726833,Fetal growth restriction caused by MIMT1 deletion alters brain transcriptome in cattle.,2013,10.1016/j.ijdevneu.2013.05.003,https://pubmed.ncbi.nlm.nih.gov/23726833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM18,ENSG00000168619,CTA,27889101,Highly heterogeneous genomic landscape of uterine leiomyomas by whole exome sequencing and genome-wide arrays.,2017,10.1016/j.fertnstert.2016.10.035,https://pubmed.ncbi.nlm.nih.gov/27889101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,42149173,Garin3 regulates sperm-oocyte fusion and male fertility.,2026,10.1007/s00018-026-06225-x,https://pubmed.ncbi.nlm.nih.gov/42149173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,41076814,Testis-specific gene C3ORF22/BC048671 is dispensable for spermiogenesis and male fertility.,2025,10.1016/j.repbio.2025.101089,https://pubmed.ncbi.nlm.nih.gov/41076814/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,41263505,ADAM5 is required for sperm-zona pellucida binding and sperm oviduct migration†.,2026,10.1093/biolre/ioaf254,https://pubmed.ncbi.nlm.nih.gov/41263505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,39928278,"Exploring miR-34a, miR-449, and ADAM2/ADAM7 Expressions as Potential Biomarkers in Male Infertility: A Combined In Silico and Experimental Approach.",2026,10.1007/s10528-025-11050-1,https://pubmed.ncbi.nlm.nih.gov/39928278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,37258521,In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.,2023,10.1038/s41467-023-38841-7,https://pubmed.ncbi.nlm.nih.gov/37258521/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,38421455,"Spem2, a novel testis-enriched gene, is required for spermiogenesis and fertilization in mice.",2024,10.1007/s00018-024-05147-w,https://pubmed.ncbi.nlm.nih.gov/38421455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,33936295,"Localization and expression of ADAM2 in the dromedary camel testis, epididymis and sperm during rutting season.",2021,10.1590/1984-3143-ar2020-0241,https://pubmed.ncbi.nlm.nih.gov/33936295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,40002966,The Surface Proteome of Bovine Unsexed and Sexed Spermatozoa.,2025,10.3390/ani15040484,https://pubmed.ncbi.nlm.nih.gov/40002966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,36355490,The Expression Patterns of Human Cancer-Testis Genes Are Induced through Epigenetic Drugs in Colon Cancer Cells.,2022,10.3390/ph15111319,https://pubmed.ncbi.nlm.nih.gov/36355490/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,32972883,Normal fertility in male mice lacking ADAM32 with testis-specific expression.,2020,10.1016/j.repbio.2020.09.001,https://pubmed.ncbi.nlm.nih.gov/32972883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,40784371,Fertilin peptide decreases embryo resorption and improves live birth rate in mouse.,2025,10.1016/j.xfss.2025.08.001,https://pubmed.ncbi.nlm.nih.gov/40784371/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,37390892,iTRAQ-based proteomic analysis provides novel insight into the postnatal testicular development of Hu sheep.,2023,10.1016/j.jprot.2023.104956,https://pubmed.ncbi.nlm.nih.gov/37390892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,27341348,Characterization of Mammalian ADAM2 and Its Absence from Human Sperm.,2016,10.1371/journal.pone.0158321,https://pubmed.ncbi.nlm.nih.gov/27341348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,26252478,"Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer.",2015,10.1371/journal.pone.0134967,https://pubmed.ncbi.nlm.nih.gov/26252478/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,36619823,RNA-sequencing attest increased sperm motility in bovine spermatozoa treated with ethanolic extract of Putranjiva roxburghii.,2023,10.1007/s13205-022-03452-4,https://pubmed.ncbi.nlm.nih.gov/36619823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,35933293,Is there a relationship between infertility and fertilin β protein distribution?,2022,10.1016/j.androl.2021.04.003,https://pubmed.ncbi.nlm.nih.gov/35933293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,35559995,Cyclic fertilin-derived peptide stimulates in vitro human embryo development.,2022,10.1016/j.xfss.2021.12.002,https://pubmed.ncbi.nlm.nih.gov/35559995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,31387901,Regulation of Iron Storage by CsrA Supports Exponential Growth of Escherichia coli.,2019,10.1128/mbio.01034-19,https://pubmed.ncbi.nlm.nih.gov/31387901/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,30396079,Effects of ADAM2 silencing on isoflurane-induced cognitive dysfunction via the P13K/Akt signaling pathway in immature rats.,2019,10.1016/j.biopha.2018.10.020,https://pubmed.ncbi.nlm.nih.gov/30396079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,35821049,Rapid divergence of a gamete recognition gene promoted macroevolution of Eutheria.,2022,10.1186/s13059-022-02721-y,https://pubmed.ncbi.nlm.nih.gov/35821049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,37670013,Author Correction: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.,2023,10.1038/s41467-023-41255-0,https://pubmed.ncbi.nlm.nih.gov/37670013/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,30348112,Vitamin D plasma concentrations in pregnant women and their preterm newborns.,2018,10.1186/s12884-018-2045-1,https://pubmed.ncbi.nlm.nih.gov/30348112/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,22017966,The Fur regulon in anaerobically grown Salmonella enterica sv. Typhimurium: identification of new Fur targets.,2011,10.1186/1471-2180-11-236,https://pubmed.ncbi.nlm.nih.gov/22017966/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,25937952,Construction and Analysis of the Cell Surface's Protein Network for Human Sperm-Egg Interaction.,2013,10.1155/2013/962760,https://pubmed.ncbi.nlm.nih.gov/25937952/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,19893039,Novel biomarkers for prostate cancer including noncoding transcripts.,2009,10.2353/ajpath.2009.080868,https://pubmed.ncbi.nlm.nih.gov/19893039/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,17023585,Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation.,2007,10.1182/blood-2006-04-014480,https://pubmed.ncbi.nlm.nih.gov/17023585/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,16929165,Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma.,2006,10.4161/cbt.5.9.3174,https://pubmed.ncbi.nlm.nih.gov/16929165/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM2,ENSG00000104755,CTA,18692807,Cyclic QDE peptide increases fertilization rates and provides healthy pups in mouse.,2009,10.1016/j.fertnstert.2008.05.088,https://pubmed.ncbi.nlm.nih.gov/18692807/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,38966569,Loss of ADAM29 does not affect viability and fertility in mice but improves wound healing.,2024,10.1016/j.isci.2024.110135,https://pubmed.ncbi.nlm.nih.gov/38966569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,38187237,"FTHL17, PRM2, CABYR, CPXCR1, ADAM29, and CABS1 are highly expressed in colon cancer patients and are regulated in vitro by epigenetic alterations.",2024,10.1016/j.heliyon.2023.e23689,https://pubmed.ncbi.nlm.nih.gov/38187237/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,41350806,A genome-wide association study identifies the GPM6A locus associated with age at onset in ALS.,2025,10.1038/s42003-025-09168-4,https://pubmed.ncbi.nlm.nih.gov/41350806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,38403804,Genetic profiling of azoospermic men to identify the etiology and predict reproductive potential.,2024,10.1007/s10815-024-03045-5,https://pubmed.ncbi.nlm.nih.gov/38403804/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,32194665,Expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelium to esophageal cancer: Their differences and clinical significance.,2020,10.3892/ol.2020.11272,https://pubmed.ncbi.nlm.nih.gov/32194665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,33164721,"Transmembrane protein ADAM29 facilitates cell proliferation, invasion and migration in clear cell renal cell carcinoma.",2021,10.1080/1120009x.2020.1842035,https://pubmed.ncbi.nlm.nih.gov/33164721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,35518925,A Synbiotic Combination of Lactobacillus gasseri 505 and Cudrania tricuspidata Leaf Extract Prevents Stress-Induced Testicular Dysfunction in Mice.,2022,10.3389/fendo.2022.835033,https://pubmed.ncbi.nlm.nih.gov/35518925/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,30008827,Clinical significance of ADAM29 promoting the invasion and growth of gastric cancer cells in vitro.,2018,10.3892/ol.2018.8838,https://pubmed.ncbi.nlm.nih.gov/30008827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,37138201,Genome-wide assessment and mapping of inbreeding depression identifies candidate genes associated with semen traits in Holstein bulls.,2023,10.1186/s12864-023-09298-1,https://pubmed.ncbi.nlm.nih.gov/37138201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,30429210,Identification of TEX101-associated Proteins Through Proteomic Measurement of Human Spermatozoa Homozygous for the Missense Variant rs35033974.,2019,10.1074/mcp.ra118.001170,https://pubmed.ncbi.nlm.nih.gov/30429210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,26977022,ADAM29 Expression in Human Breast Cancer and its Effects on Breast Cancer Cells In Vitro.,2016,,https://pubmed.ncbi.nlm.nih.gov/26977022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,30414097,A cancer tissue-specific FAM72 expression profile defines a novel glioblastoma multiform (GBM) gene-mutation signature.,2019,10.1007/s11060-018-03029-3,https://pubmed.ncbi.nlm.nih.gov/30414097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,33272581,Fermented Maillard reaction products attenuate stress-induced testicular dysfunction in mice.,2021,10.3168/jds.2020-18996,https://pubmed.ncbi.nlm.nih.gov/33272581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,21618342,Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.,2011,10.1002/humu.21477,https://pubmed.ncbi.nlm.nih.gov/21618342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,24732660,Gene expression profiles in peripheral blood mononuclear cells of Asian obstructive sleep apnea patients.,2014,10.4103/2319-4170.113188,https://pubmed.ncbi.nlm.nih.gov/24732660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,22922091,A cancer/testis antigen microarray to screen autoantibody biomarkers of non-small cell lung cancer.,2013,10.1016/j.canlet.2012.08.019,https://pubmed.ncbi.nlm.nih.gov/22922091/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,28913673,Multiple non-catalytic ADAMs are novel integrin α4 ligands.,2018,10.1007/s11010-017-3190-y,https://pubmed.ncbi.nlm.nih.gov/28913673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,25036638,Systematic identification of barriers to human iPSC generation.,2014,10.1016/j.cell.2014.05.040,https://pubmed.ncbi.nlm.nih.gov/25036638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,19340428,IGHV gene mutational status and LPL/ADAM29 gene expression as clinical outcome predictors in CLL patients in remission following treatment with oral fludarabine plus cyclophosphamide.,2009,10.1007/s00277-009-0742-6,https://pubmed.ncbi.nlm.nih.gov/19340428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,25007960,Association study of susceptibility loci with specific breast cancer subtypes in Chinese women.,2014,10.1007/s10549-014-3041-4,https://pubmed.ncbi.nlm.nih.gov/25007960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM29,ENSG00000168594,CTA,19951976,Gene expression factors as predictors of genetic risk and survival in chronic lymphocytic leukemia.,2010,10.3324/haematol.2009.010298,https://pubmed.ncbi.nlm.nih.gov/19951976/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,41391160,Multi-Omics Analysis Identified ADAM7 as a Biomarker and Therapeutic Target for End-Stage Renal Disease.,2026,10.1159/000550025,https://pubmed.ncbi.nlm.nih.gov/41391160/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,39928278,"Exploring miR-34a, miR-449, and ADAM2/ADAM7 Expressions as Potential Biomarkers in Male Infertility: A Combined In Silico and Experimental Approach.",2026,10.1007/s10528-025-11050-1,https://pubmed.ncbi.nlm.nih.gov/39928278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,39875583,Extracellular vesicles in seminal plasma of Sahiwal cattle bulls carry a differential abundance of sperm fertility-associated proteins for augmenting the functional quality of low-fertile bull spermatozoa.,2025,10.1038/s41598-025-87998-2,https://pubmed.ncbi.nlm.nih.gov/39875583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,37847080,[Delivery of epididymis-specific mRNAs from mouse epididymosomes into N2a and TM4 cells].,2023,,https://pubmed.ncbi.nlm.nih.gov/37847080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,39815273,miRNA-541-5p regulates myocardial ischemia-reperfusion injury by targeting ferroptosis.,2025,10.1186/s13019-024-03260-2,https://pubmed.ncbi.nlm.nih.gov/39815273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,40596315,ZFHX3 is integral to androgen/AR signaling involving protein association with AR in prostate cancer cells.,2025,10.1038/s41598-025-05659-w,https://pubmed.ncbi.nlm.nih.gov/40596315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,33658350,Guinea pig cytomegalovirus protective T cell antigen GP83 is a functional pp65 homolog for innate immune evasion and pentamer dependent virus tropism.,2021,10.1128/jvi.00324-21,https://pubmed.ncbi.nlm.nih.gov/33658350/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,34452332,A Fully Protective Congenital CMV Vaccine Requires Neutralizing Antibodies to Viral Pentamer and gB Glycoprotein Complexes but a pp65 T-Cell Response Is Not Necessary.,2021,10.3390/v13081467,https://pubmed.ncbi.nlm.nih.gov/34452332/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,34116022,ADAM7 promotes the proliferation and invasion in trophoblast cells.,2021,10.1016/j.yexmp.2021.104659,https://pubmed.ncbi.nlm.nih.gov/34116022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,37107551,RNA-Seq Profiling between Commercial and Indigenous Iranian Chickens Highlights Differences in Innate Immune Gene Expression.,2023,10.3390/genes14040793,https://pubmed.ncbi.nlm.nih.gov/37107551/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,38135080,Maternal urban particulate matter (SRM 1648a) exposure disrupted the cellular immune homeostasis during early life: The potential attribution of altered placental transcriptome profile.,2024,10.1016/j.scitotenv.2023.169432,https://pubmed.ncbi.nlm.nih.gov/38135080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,26246218,Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7.,2015,10.1095/biolreprod.115.130252,https://pubmed.ncbi.nlm.nih.gov/26246218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,36000848,Endothelial Cell Infection by Guinea Pig Cytomegalovirus Is a Lytic or Persistent Infection Depending on Tissue Origin but Requires Viral Pentamer Complex and pp65 Tegument Protein.,2022,10.1128/jvi.00831-22,https://pubmed.ncbi.nlm.nih.gov/36000848/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,30404807,Induction and Suppression of NF-κB Signalling by a DNA Virus of Drosophila.,2019,10.1128/jvi.01443-18,https://pubmed.ncbi.nlm.nih.gov/30404807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,32825429,Convalescent Immunity to Guinea Pig Cytomegalovirus Induces Limited Cross Strain Protection against Re-Infection but High-Level Protection against Congenital Disease.,2020,10.3390/ijms21175997,https://pubmed.ncbi.nlm.nih.gov/32825429/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,31666004,Weighted single-step GWAS identified candidate genes associated with semen traits in a Duroc boar population.,2019,10.1186/s12864-019-6164-5,https://pubmed.ncbi.nlm.nih.gov/31666004/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,27709126,Epitope Capsid-Incorporation: New Effective Approach for Vaccine Development for Chagas Disease.,2016,10.20411/pai.v1i2.114,https://pubmed.ncbi.nlm.nih.gov/27709126/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,26079615,Comparison of monovalent glycoprotein B with bivalent gB/pp65 (GP83) vaccine for congenital cytomegalovirus infection in a guinea pig model: Inclusion of GP83 reduces gB antibody response but both vaccine approaches provide equivalent protection against pup mortality.,2015,10.1016/j.vaccine.2015.06.019,https://pubmed.ncbi.nlm.nih.gov/26079615/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,27795301,Additive Protection against Congenital Cytomegalovirus Conferred by Combined Glycoprotein B/pp65 Vaccination Using a Lymphocytic Choriomeningitis Virus Vector.,2017,10.1128/cvi.00300-16,https://pubmed.ncbi.nlm.nih.gov/27795301/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,25144771,Immunization with Hexon modified adenoviral vectors integrated with gp83 epitope provides protection against Trypanosoma cruzi infection.,2014,10.1371/journal.pntd.0003089,https://pubmed.ncbi.nlm.nih.gov/25144771/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,24856783,"Development of a novel, guinea pig-specific IFN-γ ELISPOT assay and characterization of guinea pig cytomegalovirus GP83-specific cellular immune responses following immunization with a modified vaccinia virus Ankara (MVA)-vectored GP83 vaccine.",2014,10.1016/j.vaccine.2014.05.011,https://pubmed.ncbi.nlm.nih.gov/24856783/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,31484753,Inclusion of the Viral Pentamer Complex in a Vaccine Design Greatly Improves Protection against Congenital Cytomegalovirus in the Guinea Pig Model.,2019,10.1128/jvi.01442-19,https://pubmed.ncbi.nlm.nih.gov/31484753/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,24465269,An Attenuated CMV Vaccine with a Deletion in Tegument Protein GP83 (pp65 Homolog) Protects against Placental Infection and Improves Pregnancy Outcome in a Guinea Pig Challenge Model.,2013,10.2217/fvl.13.107,https://pubmed.ncbi.nlm.nih.gov/24465269/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,27334585,A Novel Non-Replication-Competent Cytomegalovirus Capsid Mutant Vaccine Strategy Is Effective in Reducing Congenital Infection.,2016,10.1128/jvi.00283-16,https://pubmed.ncbi.nlm.nih.gov/27334585/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,17299708,Preconceptual administration of an alphavirus replicon UL83 (pp65 homolog) vaccine induces humoral and cellular immunity and improves pregnancy outcome in the guinea pig model of congenital cytomegalovirus infection.,2007,10.1086/511982,https://pubmed.ncbi.nlm.nih.gov/17299708/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,20491065,Gene network analysis during early infection of human coronary artery smooth muscle cells by Trypanosoma cruzi and Its gp83 ligand.,2010,10.1002/cbdv.200900320,https://pubmed.ncbi.nlm.nih.gov/20491065/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,15331722,"Molecular, biological, and in vivo characterization of the guinea pig cytomegalovirus (CMV) homologs of the human CMV matrix proteins pp71 (UL82) and pp65 (UL83).",2004,10.1128/jvi.78.18.9872-9889.2004,https://pubmed.ncbi.nlm.nih.gov/15331722/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,25519703,Identification of a candidate prognostic gene signature by transcriptome analysis of matched pre- and post-treatment prostatic biopsies from patients with advanced prostate cancer.,2014,10.1186/1471-2407-14-977,https://pubmed.ncbi.nlm.nih.gov/25519703/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM7,ENSG00000069206,CTA,12565160,Quantitative-competitive PCR monitoring of viral load following experimental guinea pig cytomegalovirus infection.,2003,10.1016/s0166-0934(02)00265-3,https://pubmed.ncbi.nlm.nih.gov/12565160/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,42653232,"Whole-Genome Sequencing Identifies Potentially Causative Variants in <i>SOX30</i>, <i>AKAP4</i>, and <i>RNF220</i> in Non-Obstructive Azoospermia.",2026,10.3390/ijms27167230,https://pubmed.ncbi.nlm.nih.gov/42653232/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,42596579,"Physiological basis of contraceptive function of a GSK3α-selective inhibitor, manifested during epididymal sperm maturation.",2026,10.1093/molehr/gaag049,https://pubmed.ncbi.nlm.nih.gov/42596579/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,42203511,Annulus fracture underlies radiation-induced sperm dysfunction revealed by multimodal nano-imaging.,2026,10.26508/lsa.202603693,https://pubmed.ncbi.nlm.nih.gov/42203511/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,41594538,Exploration of Novel Markers in Tan Sheep Spermatogenesis.,2026,10.3390/ani16020350,https://pubmed.ncbi.nlm.nih.gov/41594538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,40567906,"Chrysin's protective effect on the expression of <i>protamine</i>, <i>Tsga10</i>, <i>Dazl</i>, and <i>Akap4</i> genes against diazinon toxin in male rats: An experimental study.",2025,10.18502/ijrm.v23i3.18778,https://pubmed.ncbi.nlm.nih.gov/40567906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,41176051,Cancer-testis antigens (CTAs) in lung cancer.,2026,10.1016/j.cca.2025.120687,https://pubmed.ncbi.nlm.nih.gov/41176051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,41516134,NSUN7 Regulates Sperm Flagella Formation at All Stages of Spermiogenesis.,2025,10.3390/ijms27010257,https://pubmed.ncbi.nlm.nih.gov/41516134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,39972276,Identification of key genes related to unilateral cryptorchidism in sheep by comprehensive transcriptomics and proteomics analyses.,2025,10.1186/s12864-024-11166-5,https://pubmed.ncbi.nlm.nih.gov/39972276/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,41135303,RPA-CRISPR-Cas12a/RPA-CRISPR-Cas12a-LFD: Two detection platforms for the rapid identification of five forensic body fluids.,2026,10.1016/j.fsigen.2025.103376,https://pubmed.ncbi.nlm.nih.gov/41135303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,40991071,Selection of tumor invasion-related genes to build a prognostic model and predict immune response and potential drugs for esophageal cancer patients based on WGCNA.,2025,10.1007/s12672-025-03095-w,https://pubmed.ncbi.nlm.nih.gov/40991071/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,38050179,"A pathogenic AKAP4 variant, p.R429H, causes male in/subfertility in humans and mice.",2023,10.1002/ctm2.1463,https://pubmed.ncbi.nlm.nih.gov/38050179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,39765132,SUMO1 modification reduces oxidative stress and SUMO1ylated AKAP4 degradation affects frozen-thawed boar sperm quality.,2025,10.1016/j.anireprosci.2024.107759,https://pubmed.ncbi.nlm.nih.gov/39765132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,42416903,Alterations in the protein lactylation landscape of sperm from patients with varicocele-associated asthenozoospermia.,2026,10.3389/fendo.2026.1791920,https://pubmed.ncbi.nlm.nih.gov/42416903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,41574549,Effects of Various Antifreeze Protein Type III Concentrations on Post-Thawed Dog Sperm Quality and Protein Expression.,2026,10.1177/19475535261416345,https://pubmed.ncbi.nlm.nih.gov/41574549/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,38027210,RNA sequencing profiles reveals progressively reduced spermatogenesis with progression in adult cryptorchidism.,2023,10.3389/fendo.2023.1271724,https://pubmed.ncbi.nlm.nih.gov/38027210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,38570187,Genetic mutation of <i>Cep76</i> results in male infertility due to abnormal sperm tail composition.,2024,10.26508/lsa.202302452,https://pubmed.ncbi.nlm.nih.gov/38570187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,37087050,Germ Cell-Specific Proteins AKAP4 and ASPX Facilitate Identification of Rare Spermatozoa in Non-Obstructive Azoospermia.,2023,10.1016/j.mcpro.2023.100556,https://pubmed.ncbi.nlm.nih.gov/37087050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,40137503,Oxidative and Molecular-Structural Alterations of Spermatozoa in Swine and Ram Exposed to the Triazole Ipconazole.,2025,10.3390/toxics13030176,https://pubmed.ncbi.nlm.nih.gov/40137503/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,40968718,Novel mutations in FSIP2 cause male infertility through multiple morphological abnormalities of the sperm flagella.,2026,10.4103/aja202542,https://pubmed.ncbi.nlm.nih.gov/40968718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,41475273,ProAKAP4 as a potential biomarker of fertility and sperm freezability in males of different species - A review.,2026,10.1016/j.repbio.2025.101176,https://pubmed.ncbi.nlm.nih.gov/41475273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,35967402,Identification of CD8<sup>+</sup> T-cell epitope from multiple myeloma-specific antigen AKAP4.,2022,10.3389/fimmu.2022.927804,https://pubmed.ncbi.nlm.nih.gov/35967402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,40311472,BDE-209 toxicity: From spermiogenesis to sexual maturity in F1 male mice.,2025,10.1016/j.ecoenv.2025.118231,https://pubmed.ncbi.nlm.nih.gov/40311472/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,38286265,Chlormequat chloride induced activation of calmodulin mediated PI3K/AKT signaling pathway led to impaired sperm quality in pubertal mice.,2024,10.1016/j.fct.2024.114475,https://pubmed.ncbi.nlm.nih.gov/38286265/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,35463817,Design of a new multi-epitope peptide vaccine for non-small cell Lung cancer via vaccinology methods: an in silico study.,2022,10.22099/mbrc.2022.42468.1697,https://pubmed.ncbi.nlm.nih.gov/35463817/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,34690620,Implementation of Vaccinomics and In-Silico Approaches to Construct Multimeric Based Vaccine Against Ovarian Cancer.,2021,10.1007/s10989-021-10294-w,https://pubmed.ncbi.nlm.nih.gov/34690620/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,35574342,"Cancer/Testis Antigens as Biomarker and Target for the Diagnosis, Prognosis, and Therapy of Lung Cancer.",2022,10.3389/fonc.2022.864159,https://pubmed.ncbi.nlm.nih.gov/35574342/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,35253625,Silencing of A-kinase anchor protein 4 inhibits the metastasis and growth of non-small cell lung cancer.,2022,10.1080/21655979.2021.1977105,https://pubmed.ncbi.nlm.nih.gov/35253625/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,40478882,Dynamic relocation of PKA regulatory subunits during sperm capacitation: Linking PKA to the CatSper signaling complex.,2025,10.1073/pnas.2501741122,https://pubmed.ncbi.nlm.nih.gov/40478882/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,37382810,Testicular Toxicity in Rats Exposed to AlCl3: a Proteomics Study.,2024,10.1007/s12011-023-03745-6,https://pubmed.ncbi.nlm.nih.gov/37382810/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,23762804,The novel cancer-testis antigen A-kinase anchor protein 4 (AKAP4) is a potential target for immunotherapy of ovarian serous carcinoma.,2013,10.4161/onci.24270,https://pubmed.ncbi.nlm.nih.gov/23762804/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,34376137,Circular RNA NF1-419 Inhibits Proliferation and Induces Apoptosis by Regulating Lipid Metabolism in Astroglioma Cells.,2022,10.2174/1574892816666210729125802,https://pubmed.ncbi.nlm.nih.gov/34376137/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,25739119,"Novel antigens in non-small cell lung cancer: SP17, AKAP4, and PTTG1 are potential immunotherapeutic targets.",2015,10.18632/oncotarget.2802,https://pubmed.ncbi.nlm.nih.gov/25739119/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,27057472,A novel cancer testis antigen target A-kinase anchor protein (AKAP4) for the early diagnosis and immunotherapy of colon cancer.,2016,10.1080/2162402x.2015.1078965,https://pubmed.ncbi.nlm.nih.gov/27057472/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP4,ENSG00000147081,CTA,9514854,"Molecular cloning of human testis mRNA specifically expressed in haploid germ cells, having structural homology with the A-kinase anchoring proteins.",1998,10.1006/bbrc.1998.8079,https://pubmed.ncbi.nlm.nih.gov/9514854/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,42072212,Ultrasound-Guided Targeted Injection to the Anterior Labral-Ligamentous Complex of the Shoulder: A Cadaveric Feasibility Study for Regenerative Therapy.,2026,10.3390/bioengineering13040418,https://pubmed.ncbi.nlm.nih.gov/42072212/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,42805121,A seven-gene signature associated with inner mitochondrial membrane protein-defined molecular subtypes for prognostic stratification in gastric cancer.,2026,10.1016/j.prp.2026.156699,https://pubmed.ncbi.nlm.nih.gov/42805121/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,40781639,Analysis of epigenetic biomarkers for diagnosis and assessment of severity in rheumatoid arthritis: a cross-sectional study.,2025,10.1186/s13075-025-03628-2,https://pubmed.ncbi.nlm.nih.gov/40781639/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,38845005,DNA methylation and stroke prognosis: an epigenome-wide association study.,2024,10.1186/s13148-024-01690-2,https://pubmed.ncbi.nlm.nih.gov/38845005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,37299906,Human Behavior Recognition via Hierarchical Patches Descriptor and Approximate Locality-Constrained Linear Coding.,2023,10.3390/s23115179,https://pubmed.ncbi.nlm.nih.gov/37299906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,35706247,Enhanced cooperation in multiplayer snowdrift games with random and dynamic groupings.,2022,10.1103/physreve.105.054309,https://pubmed.ncbi.nlm.nih.gov/35706247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,37763047,"Serum YKL-40 Levels, Leukocyte Profiles, and Acute Exacerbations of Advanced COPD.",2023,10.3390/jcm12186106,https://pubmed.ncbi.nlm.nih.gov/37763047/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,38605967,Bioinformatic validation and machine learning-based exploration of purine metabolism-related gene signatures in the context of immunotherapeutic strategies for nonspecific orbital inflammation.,2024,10.3389/fimmu.2024.1318316,https://pubmed.ncbi.nlm.nih.gov/38605967/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,30898171,Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease.,2019,10.1186/s13148-019-0636-y,https://pubmed.ncbi.nlm.nih.gov/30898171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,35140633,Anopheles gambiae Actively Metabolizes Uric Acid Following Plasmodium Infection to Limit Malaria Parasite Survival.,2021,10.3389/fphys.2021.821869,https://pubmed.ncbi.nlm.nih.gov/35140633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,30647901,Genetic associations of the response to inhaled corticosteroids in asthma: a systematic review.,2019,10.1186/s13601-018-0239-2,https://pubmed.ncbi.nlm.nih.gov/30647901/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,24938606,Analysis of cell cycle shortening and developmental interruption in Dictyostelium discoideum allC RNAi mutants.,2014,10.4238/2014.may.23.6,https://pubmed.ncbi.nlm.nih.gov/24938606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,22869547,Shortening of the cell cycle and developmental interruption in a Dictyostelium  discoideum  cell line due to RNAi-silenced expression of allantoicase.,2012,10.4238/2012.july.19.11,https://pubmed.ncbi.nlm.nih.gov/22869547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,26662428,Novel zinc protease gene isolated from Dictyostelium discoideum is structurally related to mammalian leukotriene A4 hydrolase.,2015,10.4238/2015.december.9.1,https://pubmed.ncbi.nlm.nih.gov/26662428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,29931343,Consortium-based genome-wide meta-analysis for childhood dental caries traits.,2018,10.1093/hmg/ddy237,https://pubmed.ncbi.nlm.nih.gov/29931343/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,24007181,A visual-search model observer for multislice-multiview SPECT images.,2013,10.1118/1.4818824,https://pubmed.ncbi.nlm.nih.gov/24007181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,29459480,Occupational exposure to pesticides is associated with differential DNA methylation.,2018,10.1136/oemed-2017-104787,https://pubmed.ncbi.nlm.nih.gov/29459480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,17298544,Comprehensive analysis of gene expression in testes producing haploid germ cells using DNA microarray analysis.,2007,10.1111/j.1365-2605.2006.00740.x,https://pubmed.ncbi.nlm.nih.gov/17298544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,17481667,"Tit-for-tat or win-stay, lose-shift?",2007,10.1016/j.jtbi.2007.03.027,https://pubmed.ncbi.nlm.nih.gov/17481667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,10601204,Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.,1999,10.1128/jb.181.24.7479-7484.1999,https://pubmed.ncbi.nlm.nih.gov/10601204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,42208909,Physio-transcriptomic perspectives on midgut structural disruption and metabolic imbalance underlying neodymium oxide toxicity in Bombyx mori.,2026,10.1016/j.taap.2026.117891,https://pubmed.ncbi.nlm.nih.gov/42208909/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALLC,ENSG00000151360,CTA,24792382,Genome-wide association study identifies ALLC polymorphisms correlated with FEV₁ change by corticosteroid.,2014,10.1016/j.cca.2014.04.023,https://pubmed.ncbi.nlm.nih.gov/24792382/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB17,ENSG00000154007,CTA,40461914,High-resolution optical genome mapping unveils gene disruptions in a reciprocal chromosomal translocation and severe male infertility: a case report.,2025,10.1007/s10815-025-03521-6,https://pubmed.ncbi.nlm.nih.gov/40461914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB17,ENSG00000154007,CTA,35070814,E3 ubiquitin ligase ASB17 is required for spermiation in mice.,2021,10.21037/tau-21-789,https://pubmed.ncbi.nlm.nih.gov/35070814/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB17,ENSG00000154007,CTA,36398235,Testis-enriched Asb15 is not required for spermatogenesis and male fertility in mice.,2022,,https://pubmed.ncbi.nlm.nih.gov/36398235/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB17,ENSG00000154007,CTA,33803505,E3 Ubiquitin Ligase ASB17 Promotes Apoptosis by Ubiquitylating and Degrading BCLW and MCL1.,2021,10.3390/biology10030234,https://pubmed.ncbi.nlm.nih.gov/33803505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB17,ENSG00000154007,CTA,35174103,ASB17 Facilitates the Burst of LPS-Induced Inflammation Through Maintaining TRAF6 Stability.,2022,10.3389/fcimb.2022.759077,https://pubmed.ncbi.nlm.nih.gov/35174103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB17,ENSG00000154007,CTA,36355490,The Expression Patterns of Human Cancer-Testis Genes Are Induced through Epigenetic Drugs in Colon Cancer Cells.,2022,10.3390/ph15111319,https://pubmed.ncbi.nlm.nih.gov/36355490/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB17,ENSG00000154007,CTA,35878350,Genetic Diversity and Structure of the Main Danubian Horse Paternal Genealogical Lineages Based on Microsatellite Genotyping.,2022,10.3390/vetsci9070333,https://pubmed.ncbi.nlm.nih.gov/35878350/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB17,ENSG00000154007,CTA,30566256,Development and validation of a novel 13-plex PCR system for commonly used short tandem repeats in horses (Equus caballus).,2019,10.1111/evj.13047,https://pubmed.ncbi.nlm.nih.gov/30566256/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB17,ENSG00000154007,CTA,27891245,Genetic diversity of Halla horses using microsatellite markers.,2016,10.1186/s40781-016-0120-6,https://pubmed.ncbi.nlm.nih.gov/27891245/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB17,ENSG00000154007,CTA,16434852,Parentage testing of Thoroughbred horse in Korea using microsatellite DNA typing.,2006,10.4142/jvs.2006.7.1.63,https://pubmed.ncbi.nlm.nih.gov/16434852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB17,ENSG00000154007,CTA,15204681,Expression of testis specific ankyrin repeat and SOCS box-containing 17 gene.,2004,10.1080/01485010490425485,https://pubmed.ncbi.nlm.nih.gov/15204681/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,42625859,"Dysregulation of piRNA biogenesis-associated proteins in cancer: mechanisms, evidence, and translational constraints.",2026,10.3389/fmolb.2026.1906635,https://pubmed.ncbi.nlm.nih.gov/42625859/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,41063345,GASZ directly recruits MILI to the intermitochondrial cement for piRNA biogenesis and male germ cell development.,2025,10.1093/nar/gkaf957,https://pubmed.ncbi.nlm.nih.gov/41063345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,41023308,PIWI proteins tether the piRNA biogenesis machinery to mitochondria during mammalian spermatogenesis.,2025,10.1038/s44318-025-00579-x,https://pubmed.ncbi.nlm.nih.gov/41023308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,42118831,Spatiotemporal control of PIWI compartmentalization by mitochondrial scaffolds defines pachytene piRNA pathway organization.,2026,10.1073/pnas.2533968123,https://pubmed.ncbi.nlm.nih.gov/42118831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,39804923,The piRNA protein Asz1 is essential for germ cell and gonad development in zebrafish and exhibits differential necessities in distinct types of germ granules.,2025,10.1371/journal.pgen.1010868,https://pubmed.ncbi.nlm.nih.gov/39804923/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,42341396,Studies on functional differentiation of xpr1a and xpr1b genes in zebrafish.,2026,10.1016/j.cbd.2026.101917,https://pubmed.ncbi.nlm.nih.gov/42341396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,41841572,A Potent Fibrinolytic Enzyme Alp1 from <i>Cordyceps militaris</i>: From Sequence-Function Characterization to in Vivo Antithrombotic Application.,2026,10.1021/acs.jafc.6c02229,https://pubmed.ncbi.nlm.nih.gov/41841572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,41003515,Galectin-8A Inhibits Cry11Aa Binding to ALP1 and APN 2 Receptors and Toxicity Against <i>Aedes aegypti</i> Larvae.,2025,10.3390/toxins17090451,https://pubmed.ncbi.nlm.nih.gov/41003515/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,38728119,"GASZ is indispensable for gametogenesis in the silkworm, Bombyx mori.",2024,10.1111/imb.12921,https://pubmed.ncbi.nlm.nih.gov/38728119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,38205030,GASZ self-interaction clusters mitochondria into the intermitochondrial cement for proper germ cell development.,2024,10.1093/pnasnexus/pgad480,https://pubmed.ncbi.nlm.nih.gov/38205030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,41591470,MSC-derived osteogenic cell sheets on stiffness-tuned hyaluronic acid-gelatin hydrogels.,2026,10.1039/d5tb02292d,https://pubmed.ncbi.nlm.nih.gov/41591470/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,35095021,Disruption of piRNA machinery by deletion of ASZ1/GASZ results in the expression of aberrant chimeric transcripts in gonocytes.,2022,10.1262/jrd.2021-146,https://pubmed.ncbi.nlm.nih.gov/35095021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,38886667,DNA methylation patterns in patients with asthenospermia and oligoasthenospermia.,2024,10.1186/s12864-024-10491-z,https://pubmed.ncbi.nlm.nih.gov/38886667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,38614076,Toward clinical exomes in diagnostics and management of male infertility.,2024,10.1016/j.ajhg.2024.03.013,https://pubmed.ncbi.nlm.nih.gov/38614076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,41320258,"Effects of food restriction and sex hormonal intervention on alkaline phosphatase isoenzymes in serum, liver, bone and small intestine of rats.",2025,10.2131/jts.50.661,https://pubmed.ncbi.nlm.nih.gov/41320258/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,41046840,Safety and immunogenicity of a single booster dose of the group B streptococcus AlpN candidate vaccine (GBS-AlpN) in previously vaccinated healthy women compared with a single dose in previously unvaccinated women.,2025,10.1016/j.vaccine.2025.127820,https://pubmed.ncbi.nlm.nih.gov/41046840/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,35774118,A Role of the TEX101 Interactome in the Common Aetiology Behind Male Subfertility and Testicular Germ Cell Tumor.,2022,10.3389/fonc.2022.892043,https://pubmed.ncbi.nlm.nih.gov/35774118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,42039754,The dynamic Alp landscape of <i>Streptococcus dysgalactiae</i>.,2026,10.3389/fcimb.2026.1770747,https://pubmed.ncbi.nlm.nih.gov/42039754/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,35725394,A novel role for CFTR interaction with LH and FGF in azoospermia and epididymal maldevelopment caused by cryptorchidism.,2022,10.1186/s12610-022-00160-0,https://pubmed.ncbi.nlm.nih.gov/35725394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,36710863,RNAi-based knockdown of candidate gut receptor genes altered the susceptibility of Spodoptera frugiperda and S. litura larvae to a chimeric toxin Cry1AcF.,2023,10.7717/peerj.14716,https://pubmed.ncbi.nlm.nih.gov/36710863/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,42802287,Gestational age modifies associations between Group B Streptococcus genomic characteristics and postnatal age at disease onset.,2026,10.1038/s41467-026-76999-y,https://pubmed.ncbi.nlm.nih.gov/42802287/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,42170747,"First case of penicillin-resistant <i>Streptococcus agalactiae</i> (group B <i>Streptococcus</i>) isolated from an adult patient in Italy, February 2026.",2026,10.2807/1560-7917.es.2026.31.20.2600374,https://pubmed.ncbi.nlm.nih.gov/42170747/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,40490385,Genotypic Distribution of Alpha-Like Proteins in Group B <i>Streptococcus</i> Strains Isolated in Korea: Implications for Vaccine Coverage.,2025,10.3947/ic.2024.0127,https://pubmed.ncbi.nlm.nih.gov/40490385/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,36915681,Safety and immunogenicity of the group B streptococcus vaccine AlpN in a placebo-controlled double-blind phase 1 trial.,2023,10.1016/j.isci.2023.106261,https://pubmed.ncbi.nlm.nih.gov/36915681/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,37010372,Preclinical development of a novel Group B Streptococcus (GBS) vaccine candidate for maternal immunization based upon the alpha-like protein family of GBS surface proteins (Alp).,2023,10.1002/bdr2.2173,https://pubmed.ncbi.nlm.nih.gov/37010372/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,36754766,Association of infant Rib and Alp1 surface protein N-terminal domain immunoglobulin G and invasive Group B Streptococcal disease in young infants.,2023,10.1016/j.vaccine.2023.01.071,https://pubmed.ncbi.nlm.nih.gov/36754766/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,36469700,PLGA nanoparticle with Amomum longiligulare polysaccharide 1 increased the immunogenicity of infectious bursal disease virus VP2 protein.,2023,10.1080/00071668.2022.2154639,https://pubmed.ncbi.nlm.nih.gov/36469700/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,35243418,A group B Streptococcus alpha-like protein subunit vaccine induces functionally active antibodies in humans targeting homotypic and heterotypic strains.,2022,10.1016/j.xcrm.2022.100511,https://pubmed.ncbi.nlm.nih.gov/35243418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,38711928,"Genomic insights into the diversity, virulence, and antimicrobial resistance of group B <i>Streptococcus</i> clinical isolates from Saudi Arabia.",2024,10.3389/fcimb.2024.1377993,https://pubmed.ncbi.nlm.nih.gov/38711928/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,32130954,Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation.,2020,10.1016/j.chom.2020.02.006,https://pubmed.ncbi.nlm.nih.gov/32130954/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,37275158,Population genetics of group B Streptococcus from maternal carriage in an ethnically diverse community in London.,2023,10.3389/fmicb.2023.1185753,https://pubmed.ncbi.nlm.nih.gov/37275158/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,31339308,CTLGA9 Interacts with ALP1 and APN Receptors To Modulate Cry11Aa Toxicity in Aedes aegypti.,2019,10.1021/acs.jafc.9b01840,https://pubmed.ncbi.nlm.nih.gov/31339308/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,37864071,Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision.,2023,10.1038/s41598-023-45028-z,https://pubmed.ncbi.nlm.nih.gov/37864071/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,30257487,C-Type Lectin-20 Interacts with ALP1 Receptor to Reduce Cry Toxicity in Aedes aegypti.,2018,10.3390/toxins10100390,https://pubmed.ncbi.nlm.nih.gov/30257487/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASZ1,ENSG00000154438,CTA,12040005,"Identification of Gasz, an evolutionarily conserved gene expressed exclusively in germ cells and encoding a protein with four ankyrin repeats, a sterile-alpha motif, and a basic leucine zipper.",2002,10.1210/mend.16.6.0864,https://pubmed.ncbi.nlm.nih.gov/12040005/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,42593831,BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells.,2026,10.1002/advs.77155,https://pubmed.ncbi.nlm.nih.gov/42593831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,41972556,The Molecular Characterization and Functional Analysis of <i>Pomacea canaliculata</i> Boule: A Central Player in Spermatogenesis and Male Fertility.,2026,10.3390/biology15070554,https://pubmed.ncbi.nlm.nih.gov/41972556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,41793517,Dysregulated methylation of the human BOLL promoter hinders germ cell development from spermatogonia to spermatids.,2026,10.1007/s11033-026-11633-0,https://pubmed.ncbi.nlm.nih.gov/41793517/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,42844811,An Intronic Structural Variant in GhEBS1 Drives Cotton Fruit Size Divergence by Modulating Chromatin Accessibility and Gene Expression.,2026,10.1111/pbi.70761,https://pubmed.ncbi.nlm.nih.gov/42844811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,41742712,BOLL-Containing Aggregates Mediate the Translational Regulation During Human Oogenesis.,2026,10.1111/cpr.70181,https://pubmed.ncbi.nlm.nih.gov/41742712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,42637274,A low-cost alternative to Parafilm for cotton boll weevil larval encapsulation and parasitism by Jaliscoa grandis (Hymenoptera: Pteromalidae).,2026,10.1093/jee/toag241,https://pubmed.ncbi.nlm.nih.gov/42637274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,42668463,Assessing cotton boll-opening concentration for harvest decision-making via foundation model-enhanced cross-scale phenotyping.,2026,10.1016/j.plaphe.2026.100270,https://pubmed.ncbi.nlm.nih.gov/42668463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,38732137,Effect of IL-1β on the Development of Spermatogenesis In Vitro in Normal and Busulfan-Treated Immature Mice.,2024,10.3390/ijms25094926,https://pubmed.ncbi.nlm.nih.gov/38732137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,42244126,Induction of male neogametogenesis in a three-dimensional microenvironment supporting successful fertilization and proper embryo development.,2026,10.1093/molehr/gaag036,https://pubmed.ncbi.nlm.nih.gov/42244126/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,41555558,"From flower buds to bolls: how cotton reproductive structures shape boll weevil development, reproduction and survival.",2026,10.1002/ps.70574,https://pubmed.ncbi.nlm.nih.gov/41555558/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,41618753,"Fine mapping and functional analysis of the candidate gene OFP17, regulating both seed and fruit sizes in cotton.",2026,10.1002/tpg2.70195,https://pubmed.ncbi.nlm.nih.gov/41618753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,42438919,Branch architecture and flowering time are separately regulated by GhFL and GhSP2 in cotton.,2026,10.1111/tpj.71039,https://pubmed.ncbi.nlm.nih.gov/42438919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,42795487,Effects of Co-Application of γ-Polyglutamic Acid and Chemical Fertilizer on Rhizosphere Microbial Community Structure and Function of Cotton at Different Growth Stages in an Arid Cotton Field.,2026,10.3390/microorganisms14091905,https://pubmed.ncbi.nlm.nih.gov/42795487/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,42313455,Altered source-sink dynamics influence Verticillium wilt expression in cotton.,2026,10.1094/pdis-05-26-0859-re,https://pubmed.ncbi.nlm.nih.gov/42313455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,39375288,Rapid detection of mouse spermatogenic defects by testicular cellular composition analysis via enhanced deep learning model.,2025,10.1111/andr.13773,https://pubmed.ncbi.nlm.nih.gov/39375288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,42873289,Engineering cotton with ASAL and MYB genes confer dual benefits of pest resistance and fiber improvement.,2026,10.1007/s00425-026-05194-6,https://pubmed.ncbi.nlm.nih.gov/42873289/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,37957469,"Novel Mutations Reduce Expression of Meiotic Regulators SYCE1 and BOLL in Testis of Azoospermic Men from West Bengal, India.",2024,10.1007/s43032-023-01393-8,https://pubmed.ncbi.nlm.nih.gov/37957469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,42818830,Multi-genome comparative analysis and VIGS validation suggest that <i>GhMAPKKK5</i> negatively regulates fruiting branch angle in upland cotton.,2026,10.3389/fpls.2026.1929470,https://pubmed.ncbi.nlm.nih.gov/42818830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,38808558,Human <i>circBOULE</i> RNAs as potential biomarkers for sperm quality and male infertility.,2024,10.7555/jbr.37.20230296,https://pubmed.ncbi.nlm.nih.gov/38808558/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,41788210,Cotton boll extraction and single-boll weight estimation based on UAV multispectral imagery.,2026,10.3389/fpls.2026.1772622,https://pubmed.ncbi.nlm.nih.gov/41788210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,41465672,"Susceptibility of Field Populations of <i>Frankliniella intonsa</i> to Spinetoram, Imidacloprid, and Acetamiprid in Xinjiang Cotton Fields, China.",2025,10.3390/insects16121234,https://pubmed.ncbi.nlm.nih.gov/41465672/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,42188151,Off-Season Diet and Ecology of the Boll Weevil Influence Long-Term Malathion Susceptibility.,2026,10.3390/insects17050484,https://pubmed.ncbi.nlm.nih.gov/42188151/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,41469413,The role of Bacillus megaterium PEF-1 in stimulating the growth of organic cotton under environmental stress conditions.,2025,10.1038/s41598-025-28267-0,https://pubmed.ncbi.nlm.nih.gov/41469413/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,42088034,"Comparison and screening of chemical topping agents for optimizing root-shoot coordination, photosynthetic efficiency and yield in south of the Tianshan mountains in Xinjiang.",2026,10.3389/fpls.2026.1795237,https://pubmed.ncbi.nlm.nih.gov/42088034/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,39191267,Feeding spent hemp biomass does not adversely affect fertility in rams.,2024,10.2460/ajvr.24.05.0134,https://pubmed.ncbi.nlm.nih.gov/39191267/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,38656592,Assessment of Boll Weevil Susceptibility to Isocycloseram and Ethiprole and Differential Toxicity to Natural Enemies.,2024,10.1007/s13744-024-01155-4,https://pubmed.ncbi.nlm.nih.gov/38656592/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,40822735,<i>Bonheur en boule</i>: an adapted group-based physical activity program for youth with disabilities.,2025,10.3389/fspor.2025.1580697,https://pubmed.ncbi.nlm.nih.gov/40822735/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,41234306,Straw mulching-driven microbial relay enhances soil C-N coupling and cotton yield-quality synergy.,2025,10.3389/fpls.2025.1671192,https://pubmed.ncbi.nlm.nih.gov/41234306/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,42510801,Integrated Transcriptome and Metabolome Analysis Elucidates the Regulatory Networks of Salt Stress Response During Cotton Seed Germination.,2026,10.3390/genes17070761,https://pubmed.ncbi.nlm.nih.gov/42510801/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,40343122,Advances in cotton harvesting aids.,2025,10.3389/fpls.2025.1570251,https://pubmed.ncbi.nlm.nih.gov/40343122/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,41742027,Nutrient management in calcareous soils under semi-arid environments: effects on cotton productivity and soil health.,2026,10.1186/s12870-026-08416-x,https://pubmed.ncbi.nlm.nih.gov/41742027/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,41210721,"Impact of ""dry sowing and wet emergence"" water regulation on cotton soil water and salt dynamics, root growth and yield.",2025,10.3389/fpls.2025.1685785,https://pubmed.ncbi.nlm.nih.gov/41210721/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,39000183,Genetic Analysis of an F2 Population Derived from the Cotton Landrace Hopi Identified Novel Loci for Boll Glanding.,2024,10.3390/ijms25137080,https://pubmed.ncbi.nlm.nih.gov/39000183/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,40755794,Analysis of combining ability and stability of yield characteristics of upland cotton in two years.,2025,10.7717/peerj.19716,https://pubmed.ncbi.nlm.nih.gov/40755794/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,41436572,Moringa bio-stimulant promoted cotton production via coordinating anti-oxidants and physiological behaviors to combat reproductive drought stress.,2025,10.1038/s41598-025-33402-y,https://pubmed.ncbi.nlm.nih.gov/41436572/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,41437143,Intercropping-mediated enrichment of core microbiome enhances suppression of Verticillium wilt in cotton.,2025,10.1186/s40793-025-00840-0,https://pubmed.ncbi.nlm.nih.gov/41437143/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,41246435,Role of pollen beetles (<i>Carpophilus aterrimus</i>: Nitidulidae) in cotton pollination and their interaction with honeybees (<i>Apis mellifera</i>: Apidae).,2025,10.5455/ovj.2025.v15.i10.25,https://pubmed.ncbi.nlm.nih.gov/41246435/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,39652641,Pesticide use in integrated pest and pollinator management framework to protect pollinator health.,2025,10.1002/ps.8582,https://pubmed.ncbi.nlm.nih.gov/39652641/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,17114206,Association of three isoforms of the meiotic BOULE gene with spermatogenic failure in infertile men.,2007,10.1093/molehr/gal101,https://pubmed.ncbi.nlm.nih.gov/17114206/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOLL,ENSG00000152430,CTA,11390979,A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans.,2001,10.1073/pnas.131090498,https://pubmed.ncbi.nlm.nih.gov/11390979/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA3,ENSG00000131059,CTA,42168221,C2orf74 orchestrates germ-Leydig crosstalk to inhibit white adipose tissue browning in male mice.,2026,10.1038/s41467-026-73368-7,https://pubmed.ncbi.nlm.nih.gov/42168221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA3,ENSG00000131059,CTA,40415790,Subacute exposure to apigenin induces changes in protein synthesis in the liver of Swiss mice.,2025,10.3389/fphys.2025.1576310,https://pubmed.ncbi.nlm.nih.gov/40415790/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA3,ENSG00000131059,CTA,39923055,Genetic determinants of skin ageing: a systematic review and meta-analysis of genome-wide association studies and candidate genes.,2025,10.1186/s40101-025-00384-9,https://pubmed.ncbi.nlm.nih.gov/39923055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C10orf120,ENSG00000183559,CTA,36871790,C9orf131 and C10orf120 are not essential for male fertility in humans or mice.,2023,10.1016/j.ydbio.2023.02.009,https://pubmed.ncbi.nlm.nih.gov/36871790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C10orf53,ENSG00000178645,CTA,39652066,Linking Iris Cis-Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics.,2024,10.1167/iovs.65.14.18,https://pubmed.ncbi.nlm.nih.gov/39652066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C10orf53,ENSG00000178645,CTA,39329449,DNA methylation as a new tool for the differential diagnosis between T-LBL and lymphocyte-rich thymoma.,2024,10.1002/path.6346,https://pubmed.ncbi.nlm.nih.gov/39329449/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C10orf53,ENSG00000178645,CTA,29764005,Identification of Novel Functional Variants of SIN3A and SRSF1 among Somatic Variants in Acute Myeloid Leukemia Patients.,2018,10.14348/molcells.2018.0051,https://pubmed.ncbi.nlm.nih.gov/29764005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C11orf42,ENSG00000180878,CTA,33426787,Combined RNA/tissue profiling identifies novel Cancer/testis genes.,2021,10.1002/1878-0261.12900,https://pubmed.ncbi.nlm.nih.gov/33426787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C11orf42,ENSG00000180878,CTA,34791601,Whole Exome Sequencing Identifies Somatic Variants in an Oral Composite Hemangioendothelioma Characterized by YAP1-MAML2 Fusion.,2022,10.1007/s12105-021-01393-7,https://pubmed.ncbi.nlm.nih.gov/34791601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C11orf42,ENSG00000180878,CTA,41687307,In silico characterisation of C11orf42 as a potential therapeutic target in triple-negative breast cancer.,2026,10.1016/j.compbiolchem.2026.108940,https://pubmed.ncbi.nlm.nih.gov/41687307/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C12orf50,ENSG00000165805,CTA,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf78,ENSG00000166152,CTA,40938846,Gene expression alterations in testicular biopsies from males with spermatogenesis arrest identified by transcriptome analysis.,2025,10.1371/journal.pone.0332025,https://pubmed.ncbi.nlm.nih.gov/40938846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf82,ENSG00000234186,CTA,34200970,Genetic Susceptibility to Periodontal Disease in Down Syndrome: A Case-Control Study.,2021,10.3390/ijms22126274,https://pubmed.ncbi.nlm.nih.gov/34200970/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf90,ENSG00000215131,CTA,34446064,Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.,2021,10.1186/s13073-021-00917-8,https://pubmed.ncbi.nlm.nih.gov/34446064/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf96,ENSG00000205832,CTA,36259570,Identification of risk genes in Chinese nonobstructive azoospermia patients based on whole-exome sequencing.,2023,10.4103/aja202275,https://pubmed.ncbi.nlm.nih.gov/36259570/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf96,ENSG00000205832,CTA,38672648,Discovery of Novel Potential Prognostic Markers and Targeted Therapy to Overcome Chemotherapy Resistance in an Advanced-Stage Wilms Tumor.,2024,10.3390/cancers16081567,https://pubmed.ncbi.nlm.nih.gov/38672648/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf96,ENSG00000205832,CTA,31053105,Identification of novel sarcoma risk genes using a two-stage genome wide DNA sequencing strategy in cancer cluster families and population case and control cohorts.,2019,10.1186/s12881-019-0808-9,https://pubmed.ncbi.nlm.nih.gov/31053105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C17orf50,ENSG00000270806,CTA,42276287,Identification and characterization of a novel Plakoglobin-binding protein highly expressed in the testes.,2026,10.1016/j.bbamcr.2026.120170,https://pubmed.ncbi.nlm.nih.gov/42276287/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C18orf63,ENSG00000206043,CTA,41868793,CAMK1D as a potential therapeutic target for gut microbiota-driven promotion of lung adenocarcinoma development.,2026,10.7717/peerj.20985,https://pubmed.ncbi.nlm.nih.gov/41868793/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C18orf63,ENSG00000206043,CTA,39060246,Distinct saliva DNA methylation profiles in relation to treatment outcome in youth with posttraumatic stress disorder.,2024,10.1038/s41398-024-02892-1,https://pubmed.ncbi.nlm.nih.gov/39060246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf185,ENSG00000204006,CTA,35011680,Combined Use of Whole Exome Sequencing and CRISPR/Cas9 to Study the Etiology of Non-Obstructive Azoospermia: Demonstration of the Dispensable Role of the Testis-Specific Genes C1orf185 and CCT6B.,2021,10.3390/cells11010118,https://pubmed.ncbi.nlm.nih.gov/35011680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf185,ENSG00000204006,CTA,39020091,Causal relationship between type 2 diabetes and glioblastoma: bidirectional Mendelian randomization analysis.,2024,10.1038/s41598-024-67341-x,https://pubmed.ncbi.nlm.nih.gov/39020091/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf94,ENSG00000142698,CTA,41869074,Discovery of genetic susceptibility variants in pediatric and adult ependymoma.,2026,10.1093/noajnl/vdag004,https://pubmed.ncbi.nlm.nih.gov/41869074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C20orf141,ENSG00000258713,CTA,39331921,Transcriptome analysis revealed a novel nine-gene prognostic risk score of clear cell renal cell carcinoma.,2024,10.1097/md.0000000000039678,https://pubmed.ncbi.nlm.nih.gov/39331921/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C20orf141,ENSG00000258713,CTA,33209196,Construction and validation of a seven-gene signature for predicting overall survival in patients with kidney renal clear cell carcinoma via an integrated bioinformatics analysis.,2020,10.1080/19768354.2020.1760932,https://pubmed.ncbi.nlm.nih.gov/33209196/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C20orf144,ENSG00000149609,CTA,41074104,Saliva as a potential and non-invasive approach to identify upregulated genes associated with comorbidities of T1DM: a brief report.,2025,10.1186/s40001-025-03105-1,https://pubmed.ncbi.nlm.nih.gov/41074104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C20orf173,ENSG00000125975,CTA,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C20orf173,ENSG00000125975,CTA,40616090,Proteomic discovery analysis of quantitatively assessed emphysema in the general population. The MESA Lung Study.,2025,10.1186/s12931-025-03312-8,https://pubmed.ncbi.nlm.nih.gov/40616090/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C3orf22,ENSG00000180697,CTA,41076814,Testis-specific gene C3ORF22/BC048671 is dispensable for spermiogenesis and male fertility.,2025,10.1016/j.repbio.2025.101089,https://pubmed.ncbi.nlm.nih.gov/41076814/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C4orf51,ENSG00000237136,CTA,36658263,Investigating genetic variants for treatment response to selective serotonin reuptake inhibitors in syndromal factors and side effects among patients with depression in Taiwanese Han population.,2023,10.1038/s41397-023-00298-8,https://pubmed.ncbi.nlm.nih.gov/36658263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf47,ENSG00000185056,CTA,32592116,"Evolutionarily conserved and testis-specific gene, 4930524B15Rik, is not essential for mouse spermatogenesis and fertility.",2020,10.1007/s11033-020-05595-0,https://pubmed.ncbi.nlm.nih.gov/32592116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf47,ENSG00000185056,CTA,26616883,Exome and regulatory element sequencing of neuromyelitis optica patients.,2015,10.1016/j.jneuroim.2015.11.002,https://pubmed.ncbi.nlm.nih.gov/26616883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf52,ENSG00000187658,CTA,39692816,Uncovering key genes and molecular mechanisms of dendritic cell dysfunction in Esophageal Cancer: implications for Novel Diagnostic and therapeutic strategies.,2024,10.1007/s12672-024-01620-x,https://pubmed.ncbi.nlm.nih.gov/39692816/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf52,ENSG00000187658,CTA,28125082,Molecular genetic findings and clinical correlations in 100 patients with Joubert syndrome and related disorders prospectively evaluated at a single center.,2017,10.1038/gim.2016.204,https://pubmed.ncbi.nlm.nih.gov/28125082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,40407971,Identification of nonfunctional CABS1 causing fertilization failure and male infertility in humans: a case report.,2025,10.1007/s10815-025-03516-3,https://pubmed.ncbi.nlm.nih.gov/40407971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,40490738,SEQSIM: A novel bioinformatics tool for comparisons of promoter regions-a case study of calcium binding protein spermatid associated 1 (CABS1).,2025,10.1186/s12859-025-06160-x,https://pubmed.ncbi.nlm.nih.gov/40490738/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,38753592,"Identification and characterization of calcium binding protein, spermatid-associated 1 (CABS1)# in selected human tissues and fluids.",2024,10.1371/journal.pone.0301855,https://pubmed.ncbi.nlm.nih.gov/38753592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,39234505,The metabolomics changes in epididymal lumen fluid of CABS1 deficient male mice potentially contribute to sperm deformity.,2024,10.3389/fendo.2024.1432612,https://pubmed.ncbi.nlm.nih.gov/39234505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,41514941,Transcriptome Sequencing and Differential Analysis of Testes of 1-Year-Old and 3-Year-Old Kazakh Horses.,2026,10.3390/biology15010100,https://pubmed.ncbi.nlm.nih.gov/41514941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,38187237,"FTHL17, PRM2, CABYR, CPXCR1, ADAM29, and CABS1 are highly expressed in colon cancer patients and are regulated in vitro by epigenetic alterations.",2024,10.1016/j.heliyon.2023.e23689,https://pubmed.ncbi.nlm.nih.gov/38187237/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,39173316,Effect of resveratrol on spermatogenesis in breeding boars and the proteomic analysis for testes.,2024,10.1016/j.repbio.2024.100930,https://pubmed.ncbi.nlm.nih.gov/39173316/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,42612345,Mineral-driven molecular signatures of energy metabolism underpin sperm motility in buffalo.,2026,10.1016/j.anireprosci.2026.108307,https://pubmed.ncbi.nlm.nih.gov/42612345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,38453924,CRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as a metastatic driver by Odam/Cabs1 gene cluster expression.,2024,10.1038/s41467-024-46370-0,https://pubmed.ncbi.nlm.nih.gov/38453924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,33440775,Cabs1 Maintains Structural Integrity of Mouse Sperm Flagella during Epididymal Transit of Sperm.,2021,10.3390/ijms22020652,https://pubmed.ncbi.nlm.nih.gov/33440775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,38799722,Sperm long non-coding RNAs as markers for ram fertility.,2024,10.3389/fvets.2024.1337939,https://pubmed.ncbi.nlm.nih.gov/38799722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,35173218,Using publicly available transcriptomic data to identify mechanistic and diagnostic biomarkers in azoospermia and overall male infertility.,2022,10.1038/s41598-022-06476-1,https://pubmed.ncbi.nlm.nih.gov/35173218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,40921116,Integration of multi-omics resources reveals genetic features associated with environmental adaptation in the Wuzhishan pig genome.,2025,10.1016/j.jtherbio.2025.104264,https://pubmed.ncbi.nlm.nih.gov/40921116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,36324508,Genetic architecture and selection of Anhui autochthonous pig population revealed by whole genome resequencing.,2022,10.3389/fgene.2022.1022261,https://pubmed.ncbi.nlm.nih.gov/36324508/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,39595990,Insights into Adaption and Growth Evolution: Genome-Wide Copy Number Variation Analysis in Chinese Hainan Yellow Cattle Using Whole-Genome Re-Sequencing Data.,2024,10.3390/ijms252211919,https://pubmed.ncbi.nlm.nih.gov/39595990/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,32692864,"Structural and posttranslational analysis of human calcium-binding protein, spermatid-associated 1.",2020,10.1002/jcb.29824,https://pubmed.ncbi.nlm.nih.gov/32692864/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,36611624,Assessing Population Structure and Signatures of Selection in Wanbei Pigs Using Whole Genome Resequencing Data.,2022,10.3390/ani13010013,https://pubmed.ncbi.nlm.nih.gov/36611624/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,28381457,"A novel biomarker associated with distress in humans: calcium-binding protein, spermatid-specific 1 (CABS1).",2017,10.1152/ajpregu.00393.2016,https://pubmed.ncbi.nlm.nih.gov/28381457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,26960363,"Identification, localization, and functional analysis of the homologues of mouse CABS1 protein in porcine testis.",2016,10.1538/expanim.15-0104,https://pubmed.ncbi.nlm.nih.gov/26960363/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABS1,ENSG00000145309,CTA,33093844,Identification of Signatures of Selection by Whole-Genome Resequencing of a Chinese Native Pig.,2020,10.3389/fgene.2020.566255,https://pubmed.ncbi.nlm.nih.gov/33093844/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,40783453,Disruption of TEX38 impairs sperm morphogenesis and the migration of sperm into the oviduct.,2025,10.1038/s42003-025-08644-1,https://pubmed.ncbi.nlm.nih.gov/40783453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,39237102,CALR3 defects disrupt sperm-zona pellucida binding in humans: new insights into male factor fertilization failure and relevant clinical therapeutic approaches.,2024,10.1093/humrep/deae205,https://pubmed.ncbi.nlm.nih.gov/39237102/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,42612345,Mineral-driven molecular signatures of energy metabolism underpin sperm motility in buffalo.,2026,10.1016/j.anireprosci.2026.108307,https://pubmed.ncbi.nlm.nih.gov/42612345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,40850582,Engineering Zymomonas mobilis for improving genetic transformation and stability of multi-gene biosynthetic pathways.,2025,10.1016/j.biortech.2025.133198,https://pubmed.ncbi.nlm.nih.gov/40850582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,37488642,Role of cellulose response transporter-like protein CRT2 in cellulase induction in Trichoderma reesei.,2023,10.1186/s13068-023-02371-7,https://pubmed.ncbi.nlm.nih.gov/37488642/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,29988065,Lack of evidence for a causal role of CALR3 in monogenic cardiomyopathy.,2018,10.1038/s41431-018-0208-1,https://pubmed.ncbi.nlm.nih.gov/29988065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,26252478,"Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer.",2015,10.1371/journal.pone.0134967,https://pubmed.ncbi.nlm.nih.gov/26252478/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,29238338,"A Novel TetR Family Transcriptional Regulator, CalR3, Negatively Controls Calcimycin Biosynthesis in Streptomyces chartreusis NRRL 3882.",2017,10.3389/fmicb.2017.02371,https://pubmed.ncbi.nlm.nih.gov/29238338/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,33427489,Quantitative 3-T Magnetic Resonance Imaging After Matrix-Associated Autologous Chondrocyte Implantation With Autologous Bone Grafting of the Knee: The Importance of Subchondral Bone Parameters.,2021,10.1177/0363546520980134,https://pubmed.ncbi.nlm.nih.gov/33427489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,35419282,Exploring the Feasibility of Utilizing Limited Gene Panel Circulating Tumor DNA Clearance as a Biomarker in Patients With Locally Advanced Non-Small Cell Lung Cancer.,2022,10.3389/fonc.2022.856132,https://pubmed.ncbi.nlm.nih.gov/35419282/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,34952470,Arabidopsis PDI11 interacts with lectin molecular chaperons calreticulin 1 and 2 through its D domain.,2022,10.1016/j.bbrc.2021.12.045,https://pubmed.ncbi.nlm.nih.gov/34952470/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,21131354,Calsperin is a testis-specific chaperone required for sperm fertility.,2011,10.1074/jbc.m110.140152,https://pubmed.ncbi.nlm.nih.gov/21131354/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,37101299,An optimized reverse β-oxidation pathway to produce selected medium-chain fatty acids in Saccharomyces cerevisiae.,2023,10.1186/s13068-023-02317-z,https://pubmed.ncbi.nlm.nih.gov/37101299/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,32206496,Design of bioactive peptides derived from CART sequence isolated from the toadfish Thalassophryne nattereri.,2020,10.1007/s13205-020-2151-4,https://pubmed.ncbi.nlm.nih.gov/32206496/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,22621904,Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa.,2012,10.1091/mbc.e11-12-1025,https://pubmed.ncbi.nlm.nih.gov/22621904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,29310583,Proteomics reveals changes in hepatic proteins during chicken embryonic development: an alternative model to study human obesity.,2018,10.1186/s12864-017-4427-6,https://pubmed.ncbi.nlm.nih.gov/29310583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,35654255,Epigenome-wide DNA methylation signature of plasma zinc and their mediation roles in the association of zinc with lung cancer risk.,2022,10.1016/j.envpol.2022.119563,https://pubmed.ncbi.nlm.nih.gov/35654255/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,17975137,Identification of a novel cancer-testis antigen CRT2 frequently expressed in various cancers using representational differential analysis.,2007,10.1158/1078-0432.ccr-07-1374,https://pubmed.ncbi.nlm.nih.gov/17975137/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,27888524,Systematic deletion of the ER lectin chaperone genes reveals their roles in vegetative growth and male gametophyte development in Arabidopsis.,2017,10.1111/tpj.13435,https://pubmed.ncbi.nlm.nih.gov/27888524/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,22357757,Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility [corrected].,2012,10.1073/pnas.1117963109,https://pubmed.ncbi.nlm.nih.gov/22357757/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,37307645,Rethinking paranoid ideation and reasoning: A pilot study based on the argumentative theory of reasoning.,2023,10.1016/j.jbtep.2023.101884,https://pubmed.ncbi.nlm.nih.gov/37307645/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,33285378,Comparative transcriptome reveals the response of oriental river prawn (Macrobrachium nipponense) to sulfide toxicity at molecular level.,2021,10.1016/j.aquatox.2020.105700,https://pubmed.ncbi.nlm.nih.gov/33285378/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,28282460,Induction of immunogenic cell death of tumors by newly synthesized heterocyclic quinone derivative.,2017,10.1371/journal.pone.0173121,https://pubmed.ncbi.nlm.nih.gov/28282460/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALR3,ENSG00000269058,CTA,12384296,Identification of a novel calreticulin isoform (Crt2) in human and mouse.,2002,10.1016/s0378-1119(02)00880-6,https://pubmed.ncbi.nlm.nih.gov/12384296/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPZA3,ENSG00000177938,CTA,38027210,RNA sequencing profiles reveals progressively reduced spermatogenesis with progression in adult cryptorchidism.,2023,10.3389/fendo.2023.1271724,https://pubmed.ncbi.nlm.nih.gov/38027210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPZA3,ENSG00000177938,CTA,38305770,Risk model based on genes regulating the response of tumor cells to T-cell-mediated killing in esophageal squamous cell carcinoma.,2024,10.18632/aging.205495,https://pubmed.ncbi.nlm.nih.gov/38305770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPZA3,ENSG00000177938,CTA,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPZA3,ENSG00000177938,CTA,27114798,Diagnosis of genetic defects through parallel assessment of PLCζ and CAPZA3 in infertile men with history of failed oocyte activation.,2016,,https://pubmed.ncbi.nlm.nih.gov/27114798/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPZA3,ENSG00000177938,CTA,35239501,SPERM FACTORS AND EGG ACTIVATION: The phenotype of PLCZ1-deficient mice.,2022,10.1530/rep-21-0438,https://pubmed.ncbi.nlm.nih.gov/35239501/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPZA3,ENSG00000177938,CTA,25354211,Genome-wide association study identifies phospholipase C zeta 1 (PLCz1) as a stallion fertility locus in Hanoverian warmblood horses.,2014,10.1371/journal.pone.0109675,https://pubmed.ncbi.nlm.nih.gov/25354211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPZA3,ENSG00000177938,CTA,19341723,A missense mutation in the Capza3 gene and disruption of F-actin organization in spermatids of repro32 infertile male mice.,2009,10.1016/j.ydbio.2009.03.020,https://pubmed.ncbi.nlm.nih.gov/19341723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPZA3,ENSG00000177938,CTA,33783607,Deciphering the complexity of sperm transcriptome reveals genes governing functional membrane and acrosome integrities potentially influence fertility.,2021,10.1007/s00441-021-03443-6,https://pubmed.ncbi.nlm.nih.gov/33783607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPZA3,ENSG00000177938,CTA,23160479,Temporal role of Sertoli cell androgen receptor expression in spermatogenic development.,2013,10.1210/me.2012-1219,https://pubmed.ncbi.nlm.nih.gov/23160479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPZA3,ENSG00000177938,CTA,20458735,Analysis of CAPZA3 localization reveals temporally discrete events during the acrosome reaction.,2010,10.1002/jcp.22211,https://pubmed.ncbi.nlm.nih.gov/20458735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPZA3,ENSG00000177938,CTA,30845913,Array CGH-based detection of CNV regions and their potential association with reproduction and other economic traits in Holsteins.,2019,10.1186/s12864-019-5552-1,https://pubmed.ncbi.nlm.nih.gov/30845913/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPZA3,ENSG00000177938,CTA,15147739,Applying proteomic methodologies to analyze the effect of hexamethylene bisacetamide (HMBA) on proliferation and differentiation of human gastric carcinoma BGC-823 cells.,2004,10.1016/j.biocel.2004.01.021,https://pubmed.ncbi.nlm.nih.gov/15147739/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPZA3,ENSG00000177938,CTA,27918162,[Mutations in genes affecting fertility of men - current routine laboratory genetic diagnostics and searching for more DNA segments and genes influencing spermatogenesis].,2016,,https://pubmed.ncbi.nlm.nih.gov/27918162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPZA3,ENSG00000177938,CTA,26700242,Phospholipase C zeta (PLCζ) and male infertility: Clinical update and topical developments.,2016,10.1016/j.jbior.2015.11.009,https://pubmed.ncbi.nlm.nih.gov/26700242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPZA3,ENSG00000177938,CTA,9406198,Expression of a testis-specific putative actin-capping protein associated with the developing acrosome during rat spermiogenesis.,1998,10.1002/(sici)1098-2795(199801)49:1<81::aid-mrd9>3.0.co;2-k,https://pubmed.ncbi.nlm.nih.gov/9406198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPZA3,ENSG00000177938,CTA,12029070,Molecular cloning and characterization of the human orthologue of male germ cell-specific actin capping protein alpha3 (cpalpha3).,2002,10.1093/molehr/8.6.531,https://pubmed.ncbi.nlm.nih.gov/12029070/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,41680579,Molecular Characterization of the Murine Catsper4 Promoter and its Regulation by CREMτ.,2026,10.1007/s43032-025-02029-9,https://pubmed.ncbi.nlm.nih.gov/41680579/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,41543154,&lt;p&gt;Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene&lt;/p&gt;.,2026,10.3892/mmr.2026.13794,https://pubmed.ncbi.nlm.nih.gov/41543154/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,41043282,Integrated application of transcriptomics and metabolomics provides insights into sexual dimorphism in Apostichopus japonicus.,2025,10.1016/j.cbd.2025.101643,https://pubmed.ncbi.nlm.nih.gov/41043282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,41762345,"Intraepididymal platelet-rich plasma improves semen cryoresistance via antioxidant, lipid and molecular modulation during the non-breeding season in rams.",2026,10.1007/s11259-026-11130-6,https://pubmed.ncbi.nlm.nih.gov/41762345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,37725640,A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking.,2023,10.1073/pnas.2304409120,https://pubmed.ncbi.nlm.nih.gov/37725640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,39506588,Identification of Potential Biomarkers Associated with Spermatogenesis in Azoospermia.,2024,10.7754/clin.lab.2024.240541,https://pubmed.ncbi.nlm.nih.gov/39506588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,37815627,Transcriptome Analysis Reveals Spermatogenesis-Related CircRNAs and LncRNAs in Goat Spermatozoa.,2024,10.1007/s10528-023-10520-8,https://pubmed.ncbi.nlm.nih.gov/37815627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,34585662,"Effect of freeze-thawing process on lipid peroxidation, miRNAs, ion channels, apoptosis and global DNA methylation in ram spermatozoa.",2021,10.1071/rd21091,https://pubmed.ncbi.nlm.nih.gov/34585662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,38038214,"Reduction of cryopreservation-induced structural, functional and molecular damages in ram sperm by hydrated C60 fullerene.",2024,10.1111/rda.14513,https://pubmed.ncbi.nlm.nih.gov/38038214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,33536540,Detection of selection signatures for response to Aleutian mink disease virus infection in American mink.,2021,10.1038/s41598-021-82522-8,https://pubmed.ncbi.nlm.nih.gov/33536540/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,28948304,"Histological analysis and identification of spermatogenesis-related genes in 2-, 6-, and 12-month-old sheep testes.",2017,10.1007/s00114-017-1505-1,https://pubmed.ncbi.nlm.nih.gov/28948304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,21970684,"Molecular cloning, spatial and temporal expression analysis of CatSper genes in the Chinese Meishan pigs.",2011,10.1186/1477-7827-9-132,https://pubmed.ncbi.nlm.nih.gov/21970684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,17227862,Wrath of the wraiths of CatSper3 and CatSper4.,2007,10.1073/pnas.0610909104,https://pubmed.ncbi.nlm.nih.gov/17227862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,21255775,A comprehensive gene mutation screen in men with asthenozoospermia.,2011,10.1016/j.fertnstert.2010.11.067,https://pubmed.ncbi.nlm.nih.gov/21255775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,17344468,Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse.,2007,10.1095/biolreprod.107.060186,https://pubmed.ncbi.nlm.nih.gov/17344468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,16107607,Catsper3 and catsper4 encode two cation channel-like proteins exclusively expressed in the testis.,2005,10.1095/biolreprod.105.045468,https://pubmed.ncbi.nlm.nih.gov/16107607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,12932298,Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis.,2003,10.1186/1477-7827-1-53,https://pubmed.ncbi.nlm.nih.gov/12932298/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,18340633,The mouse sperm proteome characterized via IPG strip prefractionation and LC-MS/MS identification.,2008,10.1002/pmic.200701020,https://pubmed.ncbi.nlm.nih.gov/18340633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,19343178,Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.,2009,10.1371/journal.pgen.1000445,https://pubmed.ncbi.nlm.nih.gov/19343178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER4,ENSG00000188782,CTA,17347248,Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility.,2007,10.1093/molehr/gam009,https://pubmed.ncbi.nlm.nih.gov/17347248/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL2,ENSG00000175809,CTA,20657603,Human RING finger protein ZNF645 is a novel testis-specific E3 ubiquitin ligase.,2010,10.1038/aja.2010.54,https://pubmed.ncbi.nlm.nih.gov/20657603/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL2,ENSG00000175809,CTA,20587329,"Promoter demethylation mediates the expression of ZNF645, a novel cancer/testis gene.",2010,10.5483/bmbrep.2010.43.6.400,https://pubmed.ncbi.nlm.nih.gov/20587329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL2,ENSG00000175809,CTA,29505567,Clinical and genetic characteristics of 15 families with hereditary hypophosphatemia: Novel Mutations in PHEX and SLC34A3.,2018,10.1371/journal.pone.0193388,https://pubmed.ncbi.nlm.nih.gov/29505567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL2,ENSG00000175809,CTA,22252131,Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin.,2012,10.1038/emboj.2011.496,https://pubmed.ncbi.nlm.nih.gov/22252131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY2,ENSG00000174015,CTA,40342883,The Predictive Value of Serum Follicle-stimulating Hormone Level and Testicular Volume on the Outcome of Spermatozoa Retrieval from Testes in Men with Non-obstructive Azoospermia - A Retrospective Cohort Study.,2025,10.4103/jhrs.jhrs_9_25,https://pubmed.ncbi.nlm.nih.gov/40342883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY2,ENSG00000174015,CTA,40453182,"Development of a procedure for isolation, identification and quality assessment of bovine spermatids and evaluation of their fertilizing ability &lt;i&gt;in vitro&lt;/i&gt;.",2025,10.3389/fbioe.2025.1581019,https://pubmed.ncbi.nlm.nih.gov/40453182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY2,ENSG00000174015,CTA,38733656,Identification of a novel mutation in chibby family member 2 in a non-obstructive azoospermic patient.,2024,10.1016/j.repbio.2024.100891,https://pubmed.ncbi.nlm.nih.gov/38733656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY2,ENSG00000174015,CTA,41310422,miCDER: a context-aware transformer model for joint miRNA-disease entity and multi-level regulatory relation extraction.,2025,10.1186/s12864-025-12342-x,https://pubmed.ncbi.nlm.nih.gov/41310422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY2,ENSG00000174015,CTA,35299232,Whole-exome sequencing in a Japanese multiplex family identifies new susceptibility genes for intracranial aneurysms.,2022,10.1371/journal.pone.0265359,https://pubmed.ncbi.nlm.nih.gov/35299232/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY2,ENSG00000174015,CTA,39484215,COADREADx: A comprehensive algorithmic dissection of colorectal cancer unravels salient biomarkers and actionable insights into its discrete progression.,2024,10.7717/peerj.18347,https://pubmed.ncbi.nlm.nih.gov/39484215/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY2,ENSG00000174015,CTA,34290169,CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice.,2022,10.4103/aja.aja_63_21,https://pubmed.ncbi.nlm.nih.gov/34290169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY2,ENSG00000174015,CTA,40564006,Effect of Recombinant Human Growth Hormone (rhGH) Use on Genetic Methylation Patterns and Their Relationship with Body Composition in Small-for-Gestational-Age (SGA) Newborns.,2025,10.3390/biomedicines13061288,https://pubmed.ncbi.nlm.nih.gov/40564006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY2,ENSG00000174015,CTA,39961484,Comparative proteomics and phosphoproteomics analysis reveals differential sperm motility in Mediterranean buffalo semen.,2025,10.1016/j.jprot.2025.105401,https://pubmed.ncbi.nlm.nih.gov/39961484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY2,ENSG00000174015,CTA,39905013,A Chinese Knowledge Graph Dataset in the Field of Scientific Fitness.,2025,10.1038/s41597-025-04519-6,https://pubmed.ncbi.nlm.nih.gov/39905013/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY2,ENSG00000174015,CTA,40306017,Alzheimer's disease knowledge graph enhances knowledge discovery and disease prediction.,2025,10.1016/j.compbiomed.2025.110285,https://pubmed.ncbi.nlm.nih.gov/40306017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY2,ENSG00000174015,CTA,36134028,A p53 transcriptional signature in primary and metastatic cancers derived using machine learning.,2022,10.3389/fgene.2022.987238,https://pubmed.ncbi.nlm.nih.gov/36134028/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY2,ENSG00000174015,CTA,34937824,SPERT gene silencing inhibits the growth of human colon cancer xenograft tumor in nude mice via p38MAPK/HSP27 signaling pathway.,2021,10.2220/biomedres.42.247,https://pubmed.ncbi.nlm.nih.gov/34937824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY2,ENSG00000174015,CTA,35709667,Mixed model-based eQTL analysis reveals lncRNAs associated with regulation of genes involved in sex determination and spermatogenesis: The key to understanding human gender imbalance.,2022,10.1016/j.compbiolchem.2022.107713,https://pubmed.ncbi.nlm.nih.gov/35709667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY2,ENSG00000174015,CTA,29845259,shRNA‑induced knockdown of the SPERT gene inhibits proliferation and promotes apoptosis of human colorectal cancer RKO cells.,2018,10.3892/or.2018.6455,https://pubmed.ncbi.nlm.nih.gov/29845259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY2,ENSG00000174015,CTA,31438838,Genome-wide association scan for QTL and their positional candidate genes associated with internal organ traits in chickens.,2019,10.1186/s12864-019-6040-3,https://pubmed.ncbi.nlm.nih.gov/31438838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY2,ENSG00000174015,CTA,19846894,"Recommendations for safety planning, data collection, evaluation and reporting during drug, biologic and vaccine development: a report of the safety planning, evaluation, and reporting team.",2009,10.1177/1740774509344101,https://pubmed.ncbi.nlm.nih.gov/19846894/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY2,ENSG00000174015,CTA,33536340,ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility.,2021,10.1073/pnas.2018355118,https://pubmed.ncbi.nlm.nih.gov/33536340/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC116,ENSG00000161180,CTA,41581221,Identifying expression and DNA methylation biomarkers for lung adenocarcinoma risk in East Asia.,2026,10.1093/jnci/djag021,https://pubmed.ncbi.nlm.nih.gov/41581221/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC116,ENSG00000161180,CTA,41401801,Nε-Carboxymethyl-Lysine Drives Centrosome Amplification and Hepatocarcinogenesis via Pathological Dysregulation of the PLK1-CEP20-CCDC116 Axis.,2025,10.1021/acs.jafc.5c10762,https://pubmed.ncbi.nlm.nih.gov/41401801/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC116,ENSG00000161180,CTA,41878161,Single-cell and multi-omics analyses identify CAMP-associated neutrophil remodeling during radiochemotherapy in cervical cancer.,2026,10.3389/fcell.2026.1773562,https://pubmed.ncbi.nlm.nih.gov/41878161/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC116,ENSG00000161180,CTA,28653172,A cis-eQTL genetic variant of the cancer-testis gene CCDC116 is associated with risk of multiple cancers.,2017,10.1007/s00439-017-1827-2,https://pubmed.ncbi.nlm.nih.gov/28653172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC116,ENSG00000161180,CTA,23072936,Expression of the coiled coil domain containing protein 116 in the pancreatic islets and endocrine pancreatic tumors.,2012,10.4161/isl.22416,https://pubmed.ncbi.nlm.nih.gov/23072936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC116,ENSG00000161180,CTA,25074808,Proteomic analysis of mammalian sperm cells identifies new components of the centrosome.,2014,10.1242/jcs.157008,https://pubmed.ncbi.nlm.nih.gov/25074808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC116,ENSG00000161180,CTA,29193083,Integrating expression-related SNPs into genome-wide gene- and pathway-based analyses identified novel lung cancer susceptibility genes.,2018,10.1002/ijc.31182,https://pubmed.ncbi.nlm.nih.gov/29193083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC158,ENSG00000163749,CTA,39319391,CCDC158: A novel regulator in renal proximal tubular endocytosis unveiled through exome sequencing and interactome analysis.,2024,10.1002/jcp.31447,https://pubmed.ncbi.nlm.nih.gov/39319391/,annotation citations | normal,Discussed in explicit gene adjudication; see its review depth and limitations
CCDC158,ENSG00000163749,CTA,40684225,Integrating parental genomes to reduce reference bias and identify intramuscular fat genes in Qinchuan Black pigs.,2025,10.1186/s40104-025-01236-3,https://pubmed.ncbi.nlm.nih.gov/40684225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC158,ENSG00000163749,CTA,40485680,Clinical and Metabolic Signatures of &lt;i&gt;FAM47E&lt;/i&gt;-&lt;i&gt;SHROOM3&lt;/i&gt; Haplotypes in a General Population Sample.,2025,10.1016/j.ekir.2025.02.018,https://pubmed.ncbi.nlm.nih.gov/40485680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC158,ENSG00000163749,CTA,34899825,Pathway Association Studies Reveal Gene Loci and Pathway Networks that Associated With Plasma Cystatin C Levels.,2021,10.3389/fgene.2021.711155,https://pubmed.ncbi.nlm.nih.gov/34899825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC158,ENSG00000163749,CTA,32332111,Genome-Wide DNA Methylation and RNA Analysis Reveal Potential Mechanism of Resistance to Streptococcus agalactiae in GIFT Strain of Nile Tilapia (Oreochromis niloticus ).,2020,10.4049/jimmunol.1901496,https://pubmed.ncbi.nlm.nih.gov/32332111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC158,ENSG00000163749,CTA,20419844,LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma.,2010,10.3748/wjg.v16.i16.2046,https://pubmed.ncbi.nlm.nih.gov/20419844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC185,ENSG00000178395,CTA,36099812,Genetic landscape of a large cohort of Primary Ovarian Insufficiency: New genes and pathways and implications for personalized medicine.,2022,10.1016/j.ebiom.2022.104246,https://pubmed.ncbi.nlm.nih.gov/36099812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC42,ENSG00000161973,CTA,38038747,CCDC146 is required for sperm flagellum biogenesis and male fertility in mice.,2023,10.1007/s00018-023-05025-x,https://pubmed.ncbi.nlm.nih.gov/38038747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC42,ENSG00000161973,CTA,41224710,Distinct Co-methylation Patterns in African and European Populations and Their Genetic Associations.,2025,10.1093/gpbjnl/qzaf096,https://pubmed.ncbi.nlm.nih.gov/41224710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC42,ENSG00000161973,CTA,40503472,Identification of Novel Genetic Loci for Parkinson's Disease Using Whole-Exome and Whole-Genome Sequencing.,2025,10.5152/pcp.2025.24889,https://pubmed.ncbi.nlm.nih.gov/40503472/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC42,ENSG00000161973,CTA,38602507,CFAP58 is involved in the sperm head shaping and flagellogenesis of cattle and mice.,2024,10.1242/dev.202608,https://pubmed.ncbi.nlm.nih.gov/38602507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC42,ENSG00000161973,CTA,31475146,"CCDC42 Localizes to Manchette, HTCA and Tail and Interacts With ODF1 and ODF2 in the Formation of the Male Germ Cell Cytoskeleton.",2019,10.3389/fcell.2019.00151,https://pubmed.ncbi.nlm.nih.gov/31475146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC42,ENSG00000161973,CTA,39744838,Single-Cell Transcriptomics Identifies Selective Lineage-Specific Regulation of Genes in Aortic Smooth Muscle Cells in Mice.,2025,10.1161/atvbaha.124.321482,https://pubmed.ncbi.nlm.nih.gov/39744838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC42,ENSG00000161973,CTA,35587122,CCDC38 is required for sperm flagellum biogenesis and male fertility in mice.,2022,10.1242/dev.200516,https://pubmed.ncbi.nlm.nih.gov/35587122/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC42,ENSG00000161973,CTA,39457566,Associations between Disc Hemorrhage and Primary Open-Angle Glaucoma Based on Genome-Wide Association and Mendelian Randomization Analyses.,2024,10.3390/biomedicines12102253,https://pubmed.ncbi.nlm.nih.gov/39457566/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC42,ENSG00000161973,CTA,26945718,Coiled-coil domain containing 42 (Ccdc42) is necessary for proper sperm development and male fertility in the mouse.,2016,10.1016/j.ydbio.2016.01.042,https://pubmed.ncbi.nlm.nih.gov/26945718/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC42,ENSG00000161973,CTA,35015293,Histone Methylation Regulates Gene Expression in the Round Spermatids to Set the RNA Payloads of Sperm.,2022,10.1007/s43032-021-00837-3,https://pubmed.ncbi.nlm.nih.gov/35015293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC42,ENSG00000161973,CTA,27936112,Genome-Wide Association of Heroin Dependence in Han Chinese.,2016,10.1371/journal.pone.0167388,https://pubmed.ncbi.nlm.nih.gov/27936112/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC54,ENSG00000138483,CTA,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC54,ENSG00000138483,CTA,29866902,Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes.,2018,10.1242/dev.164855,https://pubmed.ncbi.nlm.nih.gov/29866902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC54,ENSG00000138483,CTA,34217363,Admixture mapping reveals the association between Native American ancestry at 3q13.11 and reduced risk of Alzheimer's disease in Caribbean Hispanics.,2021,10.1186/s13195-021-00866-9,https://pubmed.ncbi.nlm.nih.gov/34217363/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC70,ENSG00000123171,CTA,36766254,Identification of New Candidate Genes Related to Semen Traits in Duroc Pigs through Weighted Single-Step GWAS.,2023,10.3390/ani13030365,https://pubmed.ncbi.nlm.nih.gov/36766254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC70,ENSG00000123171,CTA,26931019,[Expression characteristics of the Ccdc70 gene in the mouse testis during spermatogenesis].,2016,,https://pubmed.ncbi.nlm.nih.gov/26931019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC83,ENSG00000150676,CTA,34065612,"Cancer Testis Antigen, NOL4, Is an Immunogenic Antigen Specifically Expressed in Small-Cell Lung Cancer.",2021,10.3390/curroncol28030179,https://pubmed.ncbi.nlm.nih.gov/34065612/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC83,ENSG00000150676,CTA,34359134,Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profiles in Testes of Calves and Sexually Mature Wandong Bulls (Bos taurus).,2021,10.3390/ani11072006,https://pubmed.ncbi.nlm.nih.gov/34359134/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC83,ENSG00000150676,CTA,22923163,KP-CoT-23 (CCDC83) is a novel immunogenic cancer/testis antigen in colon             cancer.,2012,10.3892/ijo.2012.1601,https://pubmed.ncbi.nlm.nih.gov/22923163/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC87,ENSG00000182791,CTA,29733332,Ccdc87 is critical for sperm function and male fertility.,2018,10.1093/biolre/ioy106,https://pubmed.ncbi.nlm.nih.gov/29733332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCER1,ENSG00000197651,CTA,41670399,CCER1 condensates participate in histone-to-protamine transition by recruiting the TIP60/EPC1/NuA4 acetyltransferase complex.,2026,10.1242/dev.205326,https://pubmed.ncbi.nlm.nih.gov/41670399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCER1,ENSG00000197651,CTA,38081819,Phase-separated CCER1 coordinates the histone-to-protamine transition and male fertility.,2023,10.1038/s41467-023-43480-z,https://pubmed.ncbi.nlm.nih.gov/38081819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCER1,ENSG00000197651,CTA,41269209,HPV Integration in Head and Neck Cancer: Downstream Splicing Events and Expression Ratios Linked with Poor Outcomes.,2026,10.1158/1078-0432.ccr-25-0645,https://pubmed.ncbi.nlm.nih.gov/41269209/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCER1,ENSG00000197651,CTA,17967063,Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters.,2007,10.1371/journal.pgen.0030181,https://pubmed.ncbi.nlm.nih.gov/17967063/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT8L2,ENSG00000198445,CTA,42068033,Integrated 2D-3D Proteomic Profiling Identifies MLK4 as a Microenvironment-Responsive Regulator of Chemotherapeutic Resistance in Human Glioblastoma Cells.,2026,10.1111/boc.70068,https://pubmed.ncbi.nlm.nih.gov/42068033/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT8L2,ENSG00000198445,CTA,38847481,Male infertility and perfluoroalkyl and poly-fluoroalkyl substances: evidence for alterations in phosphorylation of proteins and fertility-related functional attributes in bull spermatozoa†.,2024,10.1093/biolre/ioae089,https://pubmed.ncbi.nlm.nih.gov/38847481/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT8L2,ENSG00000198445,CTA,20193073,Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes.,2010,10.1186/1471-2148-10-64,https://pubmed.ncbi.nlm.nih.gov/20193073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY2B,ENSG00000129873,CTA,38444014,Cytogenetics investigation in 151 Brazilian infertile male patients and genomic analysis in selected cases: experience of 14 years in a public genetic service.,2024,10.1186/s13104-024-06710-1,https://pubmed.ncbi.nlm.nih.gov/38444014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY2B,ENSG00000129873,CTA,33766143,Human AZFb deletions cause distinct testicular pathologies depending on their extensions in Yq11 and the Y haplogroup: new cases and review of literature.,2021,10.1186/s13578-021-00551-2,https://pubmed.ncbi.nlm.nih.gov/33766143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY2B,ENSG00000129873,CTA,22820855,Deletion or underexpression of the Y-chromosome genes CDY2 and HSFY is associated with maturation arrest in American men with nonobstructive azoospermia.,2012,10.1038/aja.2012.55,https://pubmed.ncbi.nlm.nih.gov/22820855/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY2B,ENSG00000129873,CTA,14569460,Members of the CDY family have different expression patterns: CDY1 transcripts have the best correlation with complete spermatogenesis.,2003,10.1007/s00439-003-0990-9,https://pubmed.ncbi.nlm.nih.gov/14569460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY2B,ENSG00000129873,CTA,21660325,Site-selective labeling at Cys302 of aldehyde dehydrogenase unveils a selective mitochondrial stain.,2011,10.1039/c1mb05137g,https://pubmed.ncbi.nlm.nih.gov/21660325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY2B,ENSG00000129873,CTA,16784771,Presence of TSPY transcript and absence of transcripts of other Y chromosomal genes in a case of microscopic gonadoblastoma.,2006,10.1016/j.ygyno.2006.05.010,https://pubmed.ncbi.nlm.nih.gov/16784771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY2B,ENSG00000129873,CTA,24552450,Diversity oriented fluorescence library approach (DOFLA) for live cell imaging probe development.,2014,10.1021/ar400285f,https://pubmed.ncbi.nlm.nih.gov/24552450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY2B,ENSG00000129873,CTA,22158087,HSFY genes and the P4 palindrome in the AZFb interval of the human Y chromosome are not required for spermatocyte maturation.,2012,10.1093/humrep/der421,https://pubmed.ncbi.nlm.nih.gov/22158087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,41020723,Identification and validation of centrosome-related features predicting prognosis in hepatocellular carcinoma.,2025,10.1080/10255842.2025.2566280,https://pubmed.ncbi.nlm.nih.gov/41020723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,41475044,Intragenic overexpression of TONNEAU 1b enhances grain length and weight in durum wheat.,2026,10.1016/j.plaphy.2025.110998,https://pubmed.ncbi.nlm.nih.gov/41475044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,36892416,"CRISPR/Cas9 mutants delineate roles of Populus FT and TFL1/CEN/BFT family members in growth, dormancy release and flowering.",2023,10.1093/treephys/tpad027,https://pubmed.ncbi.nlm.nih.gov/36892416/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,31309741,Evaluation of novel highly specific antibodies to cancer testis antigen Centrin-1 for radioimmunoimaging and radioimmunotherapy of pancreatic cancer.,2019,10.1002/cam4.2379,https://pubmed.ncbi.nlm.nih.gov/31309741/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,31651332,Proteomic alterations underlie an association with teratozoospermia in obese mice sperm.,2019,10.1186/s12958-019-0530-7,https://pubmed.ncbi.nlm.nih.gov/31651332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,36048845,Exome sequencing and functional analyses revealed CETN1 variants leads to impaired cell division and male fertility.,2023,10.1093/hmg/ddac216,https://pubmed.ncbi.nlm.nih.gov/36048845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,39008339,Identification of potential differences in salivary proteomic profiles between estrus and diestrus stage of estrous cycle in dairy cows.,2024,10.1080/19396368.2024.2370328,https://pubmed.ncbi.nlm.nih.gov/39008339/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,37629094,Genomic Scan for Runs of Homozygosity and Selective Signature Analysis to Identify Candidate Genes in Large White Pigs.,2023,10.3390/ijms241612914,https://pubmed.ncbi.nlm.nih.gov/37629094/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,37699389,Centrins control chicken cone cell lipid droplet dynamics through lipid-droplet-localized SPDL1.,2023,10.1016/j.devcel.2023.08.012,https://pubmed.ncbi.nlm.nih.gov/37699389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,34868272,Structural Abnormalities of Spermatozoa in Triploid Gynogenetic Crucian Carp (Carassius auratus).,2021,10.3389/fgene.2021.783014,https://pubmed.ncbi.nlm.nih.gov/34868272/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,24252580,CETN1 is a cancer testis antigen with expression in prostate and pancreatic cancers.,2013,10.1186/2050-7771-1-22,https://pubmed.ncbi.nlm.nih.gov/24252580/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,23641067,Germline deletion of Cetn1 causes infertility in male mice.,2013,10.1242/jcs.128587,https://pubmed.ncbi.nlm.nih.gov/23641067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,34487862,High-quality Arabidopsis thaliana Genome Assembly with Nanopore and HiFi Long Reads.,2022,10.1016/j.gpb.2021.08.003,https://pubmed.ncbi.nlm.nih.gov/34487862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,30647131,Deletion of both centrin 2 (CETN2) and CETN3 destabilizes the distal connecting cilium of mouse photoreceptors.,2019,10.1074/jbc.ra118.006371,https://pubmed.ncbi.nlm.nih.gov/30647131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,34915633,[The expression of clock gene CLOCK and its clinical significance in nasopharyngeal carcinoma].,2021,10.3760/cma.j.cn112152-20210729-00558,https://pubmed.ncbi.nlm.nih.gov/34915633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,25261648,Knockdown of CETN1 inhibits breast cancer cells proliferation.,2014,,https://pubmed.ncbi.nlm.nih.gov/25261648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,30165032,Aberrant promoter methylation reduced the expression of protocadherin 17 in nasopharyngeal cancer.,2019,10.1139/bcb-2017-0343,https://pubmed.ncbi.nlm.nih.gov/30165032/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,27560164,Novel Centromeric Loci of the Wine and Beer Yeast Dekkera bruxellensis CEN1 and CEN2.,2016,10.1371/journal.pone.0161741,https://pubmed.ncbi.nlm.nih.gov/27560164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,26202054,Interaction between smoking history and gene expression levels impacts survival of breast cancer patients.,2015,10.1007/s10549-015-3507-z,https://pubmed.ncbi.nlm.nih.gov/26202054/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,26014913,Centrin-2 (Cetn2) mediated regulation of FGF/FGFR gene expression in Xenopus.,2015,10.1038/srep10283,https://pubmed.ncbi.nlm.nih.gov/26014913/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,23237525,"Anti-infectious and anti-inflammatory effects of peptide fragments sequentially derived from the antimicrobial peptide centrocin 1 isolated from the green sea urchin, Strongylocentrotus droebachiensis.",2012,10.1186/2191-0855-2-67,https://pubmed.ncbi.nlm.nih.gov/23237525/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,24284873,Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA.,2013,10.1038/srep03355,https://pubmed.ncbi.nlm.nih.gov/24284873/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CETN1,ENSG00000177143,CTA,3031471,Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation and analysis of the CEN1-ADE1-CDC15 region.,1987,10.1128/mcb.7.1.410-419.1987,https://pubmed.ncbi.nlm.nih.gov/3031471/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP97D1,ENSG00000231256,CTA,32785227,Cfap97d1 is important for flagellar axoneme maintenance and male mouse fertility.,2020,10.1371/journal.pgen.1008954,https://pubmed.ncbi.nlm.nih.gov/32785227/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP97D1,ENSG00000231256,CTA,38799722,Sperm long non-coding RNAs as markers for ram fertility.,2024,10.3389/fvets.2024.1337939,https://pubmed.ncbi.nlm.nih.gov/38799722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,42178336,"VISFATIN: a novel modulator of placental endocrinology under physiological and pathological conditions-in vitro studies involving INSR, ERK1/2, and PKA signalling pathways.",2026,10.1038/s41598-026-52422-w,https://pubmed.ncbi.nlm.nih.gov/42178336/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,40659665,Integrated bioinformatics and machine learning reveal key genes and immune mechanisms associated with uremia.,2025,10.1038/s41598-025-09950-8,https://pubmed.ncbi.nlm.nih.gov/40659665/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,37809854,Construction of 3D and 2D contrast-enhanced CT radiomics for prediction of CGB3 expression level and clinical prognosis in bladder cancer.,2023,10.1016/j.heliyon.2023.e20335,https://pubmed.ncbi.nlm.nih.gov/37809854/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,41335537,Effect of vaspin on endocrine function in human placenta. &lt;i&gt;In vitro&lt;/i&gt; studies on BeWo cells and villous explants from the third trimester of pregnancy.,2025,10.26402/jpp.2025.4.09,https://pubmed.ncbi.nlm.nih.gov/41335537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,40813429,Evaluation of serum samples in long cryopreservation for SomaScan proteomics and sex differences in elderly Japanese adults.,2025,10.1038/s41598-025-14464-4,https://pubmed.ncbi.nlm.nih.gov/40813429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,32767150,N- and O-glycosylation patterns and functional testing of CGB7 versus CGB3/5/8 variants of the human chorionic gonadotropin (hCG) beta subunit.,2020,10.1007/s10719-020-09936-w,https://pubmed.ncbi.nlm.nih.gov/32767150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,38212900,Insights into cAMP-dependent molecular mechanisms regulating expression and function of LGALS16 gene in choriocarcinoma JEG-3 cells.,2024,10.1002/cbin.12128,https://pubmed.ncbi.nlm.nih.gov/38212900/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,36308381,Identification of Malignancy in PAP Smear Samples Using the CGB3 and NOP56 Genes as Methylation Markers.,2022,10.31557/apjcp.2022.23.10.3541,https://pubmed.ncbi.nlm.nih.gov/36308381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,32957442,The Study of the Expression of CGB1 and CGB2 in Human Cancer Tissues.,2020,10.3390/genes11091082,https://pubmed.ncbi.nlm.nih.gov/32957442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,38033847,Expression and Prognostic Value of m6A RNA Methylation-Related Genes in Thyroid Cancer.,2023,10.18502/ijph.v52i9.13572,https://pubmed.ncbi.nlm.nih.gov/38033847/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,38099221,A cross-sectional analysis of syncytiotrophoblast membrane extracellular vesicles-derived transcriptomic biomarkers in early-onset preeclampsia.,2023,10.3389/fcvm.2023.1291642,https://pubmed.ncbi.nlm.nih.gov/38099221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,34820124,Association between promoter methylation and gene expression of CGB3 and NOP56 in HPV-infected cervical cancer cells.,2022,10.3892/br.2021.1484,https://pubmed.ncbi.nlm.nih.gov/34820124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,36686788,Identification and validation of signature for prognosis and immune microenvironment in gastric cancer based on m6A demethylase ALKBH5.,2022,10.3389/fonc.2022.1079402,https://pubmed.ncbi.nlm.nih.gov/36686788/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,31362717,Regulation of human chorionic gonadotropin beta subunit expression in ovarian cancer.,2019,10.1186/s12885-019-5960-2,https://pubmed.ncbi.nlm.nih.gov/31362717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,37740848,Development of a prognostic signature for immune-associated genes in bladder cancer and exploring potential drug findings.,2024,10.1007/s11255-023-03796-7,https://pubmed.ncbi.nlm.nih.gov/37740848/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,35908931,Cadmium inhibits forskolin-induced differentiation of human placental BeWo cells.,2022,10.2131/jts.47.309,https://pubmed.ncbi.nlm.nih.gov/35908931/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,35797939,Gestational SARS-CoV-2 infection is associated with placental expression of immune and trophoblast genes.,2022,10.1016/j.placenta.2022.06.017,https://pubmed.ncbi.nlm.nih.gov/35797939/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,23774837,Human chorionic gonadotropin beta subunit genes CGB1 and CGB2 are transcriptionally active in ovarian cancer.,2013,10.3390/ijms140612650,https://pubmed.ncbi.nlm.nih.gov/23774837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,32299363,Genome-wide analysis of the citrus B3 superfamily and their association with somatic embryogenesis.,2020,10.1186/s12864-020-6715-9,https://pubmed.ncbi.nlm.nih.gov/32299363/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,25063728,Methylation status of human chorionic gonadotropin beta subunit promoter and TFAP2A expression as factors regulating CGB gene expression in placenta.,2014,10.1016/j.fertnstert.2014.06.016,https://pubmed.ncbi.nlm.nih.gov/25063728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB3,ENSG00000104827,CTA,16123088,Expression of beta-subunit of HCG genes during normal and failed pregnancy.,2005,10.1093/humrep/dei261,https://pubmed.ncbi.nlm.nih.gov/16123088/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHCT1,ENSG00000141371,CTA,33566224,Expression profile analysis of a new testis-specifically expressed gene C17ORF64 and its association with cell apoptosis in MCF-7 cells.,2021,10.1007/s11033-021-06191-6,https://pubmed.ncbi.nlm.nih.gov/33566224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHCT1,ENSG00000141371,CTA,37107676,Detection of a Novel MSI2-C17orf64 Transcript in a Patient with Aggressive Adenocarcinoma of the Gastroesophageal Junction: A Case Report.,2023,10.3390/genes14040918,https://pubmed.ncbi.nlm.nih.gov/37107676/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHCT1,ENSG00000141371,CTA,30108103,Methylomic Analysis of Ovarian Cancers Identifies Tumor-Specific Alterations Readily Detectable in Early Precursor Lesions.,2018,10.1158/1078-0432.ccr-18-1199,https://pubmed.ncbi.nlm.nih.gov/30108103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHCT1,ENSG00000141371,CTA,33959635,"Identification of mRNA-, circRNA- and lncRNA- Associated ceRNA Networks and Potential Biomarkers for Preeclampsia From Umbilical Vein Endothelial Cells.",2021,10.3389/fmolb.2021.652250,https://pubmed.ncbi.nlm.nih.gov/33959635/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1A,ENSG00000177947,CTA,41284120,Genetic and epidemiologic assessment of mandibular cortical indices and bone mineral density in peripubertal children: the Generation R study.,2025,10.1007/s00784-025-06653-2,https://pubmed.ncbi.nlm.nih.gov/41284120/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1A,ENSG00000177947,CTA,38107644,Profiling the autoantibody repertoire reveals autoantibodies associated with mild cognitive impairment and dementia.,2023,10.3389/fneur.2023.1256745,https://pubmed.ncbi.nlm.nih.gov/38107644/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1A,ENSG00000177947,CTA,37054975,Comparative transcriptome analysis reveals sex bias in expression patterns of genes related to sex steroids and immunity in the skin of spinyhead croaker Collichthys lucidus.,2023,10.1111/jfb.15405,https://pubmed.ncbi.nlm.nih.gov/37054975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1A,ENSG00000177947,CTA,35145544,Identification of Key Genes Related to Postnatal Testicular Development Based on Transcriptomic Data of Testis in Hu Sheep.,2021,10.3389/fgene.2021.773695,https://pubmed.ncbi.nlm.nih.gov/35145544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1A,ENSG00000177947,CTA,38674457,Effects of Long-Term Cryopreservation on the Transcriptomes of Giant Grouper Sperm.,2024,10.3390/genes15040523,https://pubmed.ncbi.nlm.nih.gov/38674457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1A,ENSG00000177947,CTA,36506310,Integrative analyses of potential biomarkers and pathways for non-obstructive azoospermia.,2022,10.3389/fgene.2022.988047,https://pubmed.ncbi.nlm.nih.gov/36506310/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1A,ENSG00000177947,CTA,39986329,"A large-scale genome-wide association study on female genital tract polyps highlights role of DNA repair, cell proliferation, and cell growth.",2025,10.1093/humrep/deaf025,https://pubmed.ncbi.nlm.nih.gov/39986329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1A,ENSG00000177947,CTA,23396665,"Expression of Testis Specific Genes TSGA10, TEX101 and ODF3 in Breast Cancer.",2012,10.5812/ircmj.3611,https://pubmed.ncbi.nlm.nih.gov/23396665/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1A,ENSG00000177947,CTA,35015293,Histone Methylation Regulates Gene Expression in the Round Spermatids to Set the RNA Payloads of Sperm.,2022,10.1007/s43032-021-00837-3,https://pubmed.ncbi.nlm.nih.gov/35015293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1A,ENSG00000177947,CTA,24066034,Identification of male gametogenesis expressed genes from the scallop Nodipecten subnodosus by suppressive subtraction hybridization and pyrosequencing.,2013,10.1371/journal.pone.0073176,https://pubmed.ncbi.nlm.nih.gov/24066034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1A,ENSG00000177947,CTA,23096689,Expression of splice variants of cancer-testis genes ODF3 and ODF4 in the testis of a prostate cancer patient.,2012,10.4238/2012.october.4.11,https://pubmed.ncbi.nlm.nih.gov/23096689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1A,ENSG00000177947,CTA,29699202,The human transcript induced in spermatogenesis 50.,2004,10.1111/j.1447-0578.2004.00076.x,https://pubmed.ncbi.nlm.nih.gov/29699202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1A,ENSG00000177947,CTA,19886887,Elevated expression levels of testis-specific genes TEX101 and SPATA19 in basal cell carcinoma and their correlation with clinical and pathological features.,2010,10.1111/j.1365-2133.2009.09568.x,https://pubmed.ncbi.nlm.nih.gov/19886887/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1A,ENSG00000177947,CTA,20682177,"Expression of two testis-specific genes, SPATA19 and LEMD1, in prostate cancer.",2010,10.1016/j.arcmed.2010.04.003,https://pubmed.ncbi.nlm.nih.gov/20682177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1A,ENSG00000177947,CTA,11774381,Molecular cloning of Odf3 encoding a novel coiled-coil protein of sperm tail outer dense fibers.,2002,10.1002/mrd.1136,https://pubmed.ncbi.nlm.nih.gov/11774381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1A,ENSG00000177947,CTA,17901070,Flow-cytometric isolation of testicular germ cells from rainbow trout (Oncorhynchus mykiss) carrying the green fluorescent protein gene driven by trout vasa regulatory regions.,2008,10.1095/biolreprod.107.064667,https://pubmed.ncbi.nlm.nih.gov/17901070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1A,ENSG00000177947,CTA,11870087,Molecular cloning and characterization of a complementary DNA encoding sperm tail protein SHIPPO 1.,2002,10.1095/biolreprod66.3.785,https://pubmed.ncbi.nlm.nih.gov/11870087/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP2A,ENSG00000188163,CTA,42724701,Transcriptomic signatures as biomarkers for the progression of mild cognitive impairment.,2026,10.3389/fnagi.2026.1901264,https://pubmed.ncbi.nlm.nih.gov/42724701/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP2A,ENSG00000188163,CTA,42501271,Beyond the linear genome: how reference bias threatens preventive medicine and geroscience.,2026,10.1007/s11357-026-02436-z,https://pubmed.ncbi.nlm.nih.gov/42501271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP2A,ENSG00000188163,CTA,39937672,A ternary complex of MIPs in the A-tubule of basal bodies and axonemes depends on RIB22 and the EF-hand domain of RIB72A in &lt;i&gt;Tetrahymena&lt;/i&gt; cilia.,2025,10.1091/mbc.e24-12-0557,https://pubmed.ncbi.nlm.nih.gov/39937672/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP2A,ENSG00000188163,CTA,37549510,Integrated molecular-network analysis reveals infertility-associated key genes and transcription factors in the non-obstructive azoospermia.,2023,10.1016/j.ejogrb.2023.07.023,https://pubmed.ncbi.nlm.nih.gov/37549510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP4,ENSG00000185264,CTA,33760102,Testis-expressed protein 33 is not essential for spermiogenesis and fertility in mice.,2021,10.3892/mmr.2021.11956,https://pubmed.ncbi.nlm.nih.gov/33760102/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP4,ENSG00000185264,CTA,37594251,Scrutinizing the human TEX genes in the context of human male infertility.,2024,10.1111/andr.13511,https://pubmed.ncbi.nlm.nih.gov/37594251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP4,ENSG00000185264,CTA,32821546,Spermatogenesis is normal in Tex33 knockout mice.,2020,10.7717/peerj.9629,https://pubmed.ncbi.nlm.nih.gov/32821546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP4,ENSG00000185264,CTA,35627192,Cancer-Testis Gene Biomarkers Discovered in Colon Cancer Patients.,2022,10.3390/genes13050807,https://pubmed.ncbi.nlm.nih.gov/35627192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP4,ENSG00000185264,CTA,36355490,The Expression Patterns of Human Cancer-Testis Genes Are Induced through Epigenetic Drugs in Colon Cancer Cells.,2022,10.3390/ph15111319,https://pubmed.ncbi.nlm.nih.gov/36355490/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP4,ENSG00000185264,CTA,30381129,[Preparation and application of rabbit polyclonal antibody against mouse Tex33].,2018,,https://pubmed.ncbi.nlm.nih.gov/30381129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP4,ENSG00000185264,CTA,32561905,CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity.,2020,10.1093/biolre/ioaa084,https://pubmed.ncbi.nlm.nih.gov/32561905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP4,ENSG00000185264,CTA,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP4,ENSG00000185264,CTA,22332119,Identification of testis 14-3-3 binding proteins by tandem affinity purification.,2011,10.4161/spmg.1.4.18902,https://pubmed.ncbi.nlm.nih.gov/22332119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX7B2,ENSG00000170516,CTA,41639206,Integrative bioinformatics analyses of mitochondrial dysfunction-related genes in human non-obstructive azoospermia.,2026,10.1038/s41598-026-38077-7,https://pubmed.ncbi.nlm.nih.gov/41639206/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX7B2,ENSG00000170516,CTA,42201145,Methadone Maintenance Treatment vs. Long-Term Abstinence Without Opioid Agonist: Epigenome-Wide Study of DNA Methylation.,2026,10.3390/epigenomes10020029,https://pubmed.ncbi.nlm.nih.gov/42201145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX7B2,ENSG00000170516,CTA,42278032,Genome-Wide Association Study Reveals Genetic Loci Associated with Body Measurement Traits in Yanqi Horses.,2026,10.3390/ani16111597,https://pubmed.ncbi.nlm.nih.gov/42278032/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX7B2,ENSG00000170516,CTA,34326397,CRISPR/Cas9-based genetic screen of SCNT-reprogramming resistant genes identifies critical genes for male germ cell development in mice.,2021,10.1038/s41598-021-94851-9,https://pubmed.ncbi.nlm.nih.gov/34326397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX7B2,ENSG00000170516,CTA,37510369,Mutations in Structural Genes of the Mitochondrial Complex IV May Influence Breast Cancer.,2023,10.3390/genes14071465,https://pubmed.ncbi.nlm.nih.gov/37510369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX7B2,ENSG00000170516,CTA,33758763,A Novel Metabolism-Related Signature as a Candidate Prognostic Biomarker for Hepatocellular Carcinoma.,2021,10.2147/jhc.s294108,https://pubmed.ncbi.nlm.nih.gov/33758763/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX7B2,ENSG00000170516,CTA,15623157,A rare polymorphism of the COX7B2 gene in a Cantonese family with nasopharyngeal carcinoma.,2004,10.1360/03yc0037,https://pubmed.ncbi.nlm.nih.gov/15623157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX7B2,ENSG00000170516,CTA,23937595,A genome-wide search for type 2 diabetes susceptibility genes in an extended Arab family.,2013,10.1111/ahg.12036,https://pubmed.ncbi.nlm.nih.gov/23937595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPXCR1,ENSG00000147183,CTA,42899482,Tumour Antigen-Specific Antibody Signatures as Diagnostic Biomarkers for Melanoma.,2026,10.1002/ijc.70726,https://pubmed.ncbi.nlm.nih.gov/42899482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPXCR1,ENSG00000147183,CTA,38187237,"FTHL17, PRM2, CABYR, CPXCR1, ADAM29, and CABS1 are highly expressed in colon cancer patients and are regulated in vitro by epigenetic alterations.",2024,10.1016/j.heliyon.2023.e23689,https://pubmed.ncbi.nlm.nih.gov/38187237/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPXCR1,ENSG00000147183,CTA,36982982,Co-Expression Network Analysis Identifies Molecular Determinants of Loneliness Associated with Neuropsychiatric and Neurodegenerative Diseases.,2023,10.3390/ijms24065909,https://pubmed.ncbi.nlm.nih.gov/36982982/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPXCR1,ENSG00000147183,CTA,28428959,Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children.,2017,10.1155/2017/2432957,https://pubmed.ncbi.nlm.nih.gov/28428959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPXCR1,ENSG00000147183,CTA,28877219,A new approach to chromosome-wide analysis of X-linked markers identifies new associations in Asian and European case-parent triads of orofacial clefts.,2017,10.1371/journal.pone.0183772,https://pubmed.ncbi.nlm.nih.gov/28877219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPXCR1,ENSG00000147183,CTA,27609023,A 19-Gene expression signature as a predictor of survival in colorectal cancer.,2016,10.1186/s12920-016-0218-1,https://pubmed.ncbi.nlm.nih.gov/27609023/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPXCR1,ENSG00000147183,CTA,21685710,Disease-dependent differently methylated regions (D-DMRs) of DNA are enriched on the X chromosome in uterine leiomyoma.,2011,10.1262/jrd.11-035a,https://pubmed.ncbi.nlm.nih.gov/21685710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPXCR1,ENSG00000147183,CTA,11499681,Physical and transcriptional mapping of the X-linked cleft palate and ankyloglossia (CPX) critical region.,2001,10.1007/s004390100518,https://pubmed.ncbi.nlm.nih.gov/11499681/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,42090447,SARS-CoV-2 triggers an NF-kB-driven proliferative response in epididymal clear cells of K18-hACE2 mice.,2026,10.1530/raf-25-0197,https://pubmed.ncbi.nlm.nih.gov/42090447/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,41150145,Agarose Gel-Supported Culture of Cryopreserved Calf Testicular Tissues.,2025,10.3390/vetsci12101005,https://pubmed.ncbi.nlm.nih.gov/41150145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,38828560,Overexpression of PD-L1 causes germ cell failure and infertility via CRISP1/PD-L1 interaction in mouse epididymis.,2024,10.1017/s0967199424000157,https://pubmed.ncbi.nlm.nih.gov/38828560/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,40293787,The epididymis contributes to sperm DNA integrity and early embryo development through Cysteine-Rich Secretory Proteins.,2025,10.7554/elife.97105,https://pubmed.ncbi.nlm.nih.gov/40293787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,37847080,[Delivery of epididymis-specific mRNAs from mouse epididymosomes into N2a and TM4 cells].,2023,,https://pubmed.ncbi.nlm.nih.gov/37847080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,38790256,DNA Microarray and Bioinformatic Analysis Reveals the Potential of Whale Oil in Enhancing Hair Growth in a C57BL/6 Mice Dorsal Skin Model.,2024,10.3390/genes15050627,https://pubmed.ncbi.nlm.nih.gov/38790256/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,36050562,The vertebrate- and testis- specific transmembrane protein C11ORF94 plays a critical role in sperm-oocyte membrane binding.,2022,10.1186/s43556-022-00092-1,https://pubmed.ncbi.nlm.nih.gov/36050562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,35725394,A novel role for CFTR interaction with LH and FGF in azoospermia and epididymal maldevelopment caused by cryptorchidism.,2022,10.1186/s12610-022-00160-0,https://pubmed.ncbi.nlm.nih.gov/35725394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,37969811,Profiling of seminal plasma proteins to identify the fertility of Simmental bull with low semen quality.,2023,10.5455/javar.2023.j689,https://pubmed.ncbi.nlm.nih.gov/37969811/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,37098482,A cysteine-rich secretory protein involves in phytohormone melatonin mediated plant resistance to CGMMV.,2023,10.1186/s12870-023-04226-7,https://pubmed.ncbi.nlm.nih.gov/37098482/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,33750840,The less conserved metal-binding site in human CRISP1 remains sensitive to zinc ions to permit protein oligomerization.,2021,10.1038/s41598-021-84926-y,https://pubmed.ncbi.nlm.nih.gov/33750840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,36174316,Polystyrene nanoparticles enhance the adverse effects of di-(2-ethylhexyl) phthalate on male reproductive system in mice.,2022,10.1016/j.ecoenv.2022.114104,https://pubmed.ncbi.nlm.nih.gov/36174316/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,30510210,Impaired male fertility and abnormal epididymal epithelium differentiation in mice lacking CRISP1 and CRISP4.,2018,10.1038/s41598-018-35719-3,https://pubmed.ncbi.nlm.nih.gov/30510210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,33563587,Exercise Training Promotes Sex-Specific Adaptations in Mouse Inguinal White Adipose Tissue.,2021,10.2337/db20-0790,https://pubmed.ncbi.nlm.nih.gov/33563587/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,37882330,Mammalian cysteine-rich secretory proteins interact with plasma membrane Ca&lt;sup&gt;2+&lt;/sup&gt; exporter PMCA4b.,2024,10.1111/andr.13549,https://pubmed.ncbi.nlm.nih.gov/37882330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,35393522,Integrated bioinformatic analysis of gene expression profiling data to identify combinatorial biomarkers in inflammatory skin disease.,2022,10.1038/s41598-022-09840-3,https://pubmed.ncbi.nlm.nih.gov/35393522/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,34970552,Cysteine-Rich Secretory Proteins (CRISP) are Key Players in Mammalian Fertilization and Fertility.,2021,10.3389/fcell.2021.800351,https://pubmed.ncbi.nlm.nih.gov/34970552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,29361143,Epididymal cysteine-rich secretory proteins are required for epididymal sperm maturation and optimal sperm function.,2018,10.1093/molehr/gay001,https://pubmed.ncbi.nlm.nih.gov/29361143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,32513118,Evolutionary analysis of genes coding for Cysteine-RIch Secretory Proteins (CRISPs) in mammals.,2020,10.1186/s12862-020-01632-5,https://pubmed.ncbi.nlm.nih.gov/32513118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,26474686,Effect of KnockOut serum replacement on germ cell development of immature testis tissue culture.,2016,10.1016/j.theriogenology.2015.09.012,https://pubmed.ncbi.nlm.nih.gov/26474686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,27105782,The Immunogenicity of CRISP1 Plasmid-Based Contraceptive Vaccine can be Improved When Using Chitosan Nanoparticles as the Carrier.,2016,10.1111/aji.12513,https://pubmed.ncbi.nlm.nih.gov/27105782/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,28654693,Fatty acid synthase reprograms the epigenome in uterine leiomyosarcomas.,2017,10.1371/journal.pone.0179692,https://pubmed.ncbi.nlm.nih.gov/28654693/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,22429321,Immunogenicity study of plasmid DNA encoding mouse cysteine-rich secretory protein-1 (mCRISP1) as a contraceptive vaccine.,2012,10.1111/j.1600-0897.2012.01117.x,https://pubmed.ncbi.nlm.nih.gov/22429321/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP1,ENSG00000124812,CTA,29439661,Genome-wide scan for commons SNPs affecting bovine leukemia virus infection level in dairy cattle.,2018,10.1186/s12864-018-4523-2,https://pubmed.ncbi.nlm.nih.gov/29439661/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,42520801,Chromatin topology and distal elements underlie divergent cell-type-specific regulation of 9p21 locus cell cycle genes.,2026,10.1016/j.xgen.2026.101304,https://pubmed.ncbi.nlm.nih.gov/42520801/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,42069922,Decoding cis-regulatory elements in the germline of the human malaria vector Anopheles gambiae.,2026,10.1038/s42003-026-10117-y,https://pubmed.ncbi.nlm.nih.gov/42069922/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,42869657,Altered Brain Extracellular Matrix Structure and Sex-Specific Learning/Memory Dysfunction in Mice Lacking the Functional Amyloid Cystatin-Related Epididymal Spermatogenic (CRES).,2026,10.1523/eneuro.0177-26.2026,https://pubmed.ncbi.nlm.nih.gov/42869657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,42805172,Single-cell multiomics across nine mammals reveals cell-type-specific regulatory conservation in the brain.,2026,10.1016/j.xgen.2026.101367,https://pubmed.ncbi.nlm.nih.gov/42805172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,41698959,Profiling the epigenomic landscape of late embryonic and adult mouse hind limb muscles.,2026,10.1038/s41598-025-32705-4,https://pubmed.ncbi.nlm.nih.gov/41698959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,42481467,Analysis of 14q12 microdeletions reveals novel regulatory loci for the neurodevelopmental disorder-related gene FOXG1.,2026,10.1038/s41467-026-75694-2,https://pubmed.ncbi.nlm.nih.gov/42481467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,41557487,The Functional Epididymal Amyloid Cystatin-Related Epididymal Spermatogenic (CRES) is a Component of the Mammalian Brain Extracellular Matrix.,2026,10.1002/jnr.70113,https://pubmed.ncbi.nlm.nih.gov/41557487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,41188995,ERV3-MLT1 provides cis-regulatory elements for human placental functioning and are commonly dysregulated in human-specific preeclampsia.,2025,10.1186/s13059-025-03821-1,https://pubmed.ncbi.nlm.nih.gov/41188995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,42803313,Chromatin Accessibility Profiling of the Canine Brain Reveals Regulatory Programs Associated With Dog-Wolf Divergence and Human Psychiatric Risk.,2026,10.1111/1749-4877.70189,https://pubmed.ncbi.nlm.nih.gov/42803313/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,41839854,Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortex.,2026,10.1038/s41467-026-70497-x,https://pubmed.ncbi.nlm.nih.gov/41839854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,42057421,Functional and computational interrogation of juvenile idiopathic arthritis risk loci in CD4+ T cells.,2026,10.1016/j.xhgg.2026.100619,https://pubmed.ncbi.nlm.nih.gov/42057421/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,42498815,The future objectives of the International Mouse Phenotyping Consortium (IMPC): functional evaluation of human disease-relevant cis-regulatory elements in the mouse genome.,2026,10.1007/s00335-026-10258-9,https://pubmed.ncbi.nlm.nih.gov/42498815/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,42586070,Molecular co-accessibility identifies coordinated regulation between distant cis-regulatory elements.,2026,10.1016/j.molcel.2026.07.020,https://pubmed.ncbi.nlm.nih.gov/42586070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,41851468,Adaptive evolution of gene regulatory networks in mammalian neocortex.,2026,10.1038/s41586-026-10226-y,https://pubmed.ncbi.nlm.nih.gov/41851468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,42531458,Pig Matrix: a matched multiomics 3D regulatory genomics database for evolutionary and comparative analyses in pigs.,2026,10.1093/molbev/msag190,https://pubmed.ncbi.nlm.nih.gov/42531458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,42303450,Influence of &lt;i&gt;cis&lt;/i&gt;-regulatory elements on expression divergence in human segmental duplications.,2026,10.1101/gr.281526.125,https://pubmed.ncbi.nlm.nih.gov/42303450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,41899603,Crosstalk Between &lt;i&gt;Cis&lt;/i&gt;-Regulatory Elements and Metabolism Reprogramming in Hepatocellular Carcinoma.,2026,10.3390/cancers18061002,https://pubmed.ncbi.nlm.nih.gov/41899603/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,41906094,The landscape of regulatory element evolution in a C4 perennial grass.,2026,10.1186/s12864-026-12785-w,https://pubmed.ncbi.nlm.nih.gov/41906094/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,41916278,Enhancers that direct gene expression to central nervous system vascular endothelial cells in vivo.,2026,10.1016/j.neuron.2026.03.002,https://pubmed.ncbi.nlm.nih.gov/41916278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,41204375,In-silico identification and functional analysis of cis-regulatory elements in selected protein phosphatase 2A (PP2A) gene promoters of Arabidopsis thaliana reveals 5'-AAAG-3' as over-represented motif under abiotic stress condition.,2025,10.1186/s13104-025-07513-8,https://pubmed.ncbi.nlm.nih.gov/41204375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,41384350,Recipient-derived vs. donor-derived CAR-T-cell therapy in relapsed B-cell acute lymphoblastic leukemia patients after transplantation: A multi-center retrospective study.,2026,10.1097/cm9.0000000000003855,https://pubmed.ncbi.nlm.nih.gov/41384350/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,41237776,FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry.,2026,10.1016/j.immuni.2025.10.020,https://pubmed.ncbi.nlm.nih.gov/41237776/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,42671571,Genetic association stratified by HLA-DR3 and HLA-DR4 status reveals heterogeneity in pathways of progression to type 1 diabetes.,2026,10.1007/s00125-026-06836-w,https://pubmed.ncbi.nlm.nih.gov/42671571/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,42188365,Advancing Personalized Intrathecal Therapy: A Quasi-Experimental Study for the Evaluation of Patient Satisfaction and Pain in Ultrasound-Guided Versus Template-Guided Refill Techniques.,2026,10.3390/jpm16050270,https://pubmed.ncbi.nlm.nih.gov/42188365/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,41390797,Multi-omic analysis of hepatocellular carcinoma reveals aberrant cis-regulatory changes and dysregulated retrotransposons with prognostic potential.,2025,10.1038/s42003-025-09154-w,https://pubmed.ncbi.nlm.nih.gov/41390797/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,41693567,Design prokaryotic cis-regulatory elements using language model.,2026,10.1093/nar/gkag122,https://pubmed.ncbi.nlm.nih.gov/41693567/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,38730674,Adverse Reactions in Relapsed/Refractory B-Cell Lymphoma Administered with Chimeric Antigen Receptor T Cell Alone or in Combination with Autologous Stem Cell Transplantation.,2024,10.3390/cancers16091722,https://pubmed.ncbi.nlm.nih.gov/38730674/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,41299220,Multiomic analyses on the contribution of transposable elements to the cis-regulatory landscape of different types of immune cells.,2025,10.1186/s12864-025-12285-3,https://pubmed.ncbi.nlm.nih.gov/41299220/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,39896798,Utilization of donor CLL-1 CAR-T cells for the treatment of relapsed of acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation.,2024,10.3389/fimmu.2024.1491341,https://pubmed.ncbi.nlm.nih.gov/39896798/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,40867852,"Glyoxalase 1 Inducer, &lt;i&gt;trans&lt;/i&gt;-Resveratrol and Hesperetin-Dietary Supplement with Multi-Modal Health Benefits.",2025,10.3390/antiox14080956,https://pubmed.ncbi.nlm.nih.gov/40867852/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,41381368,Efficacy and safety of urate-lowering therapies in asymptomatic hyperuricaemia: a systematic review and network meta-analysis of key clinical outcomes.,2025,10.1080/07853890.2025.2597063,https://pubmed.ncbi.nlm.nih.gov/41381368/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,42792956,Cross-Model Uncertainty-Aware Minimal Editing of Cis-Regulatory Elements for Cell-Type-Selective Design.,2026,10.3390/genes17091062,https://pubmed.ncbi.nlm.nih.gov/42792956/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,37649264,Adverse events and efficacy of second-round CAR-T cell therapy in relapsed pediatric B-ALL.,2024,10.1111/ejh.14092,https://pubmed.ncbi.nlm.nih.gov/37649264/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST8,ENSG00000125815,CTA,40120334,CRES&lt;sup&gt;3&lt;/sup&gt;T: A single-arm confirmatory trial of S-1 plus cisplatin with concurrent radical-dose radiotherapy followed by surgery for superior sulcus tumors.,2025,10.1016/j.lungcan.2025.108506,https://pubmed.ncbi.nlm.nih.gov/40120334/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9L,ENSG00000101435,CTA,25612291,Borderline personality disorder and childhood maltreatment: a genome-wide methylation analysis.,2015,10.1111/gbb.12197,https://pubmed.ncbi.nlm.nih.gov/25612291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9L,ENSG00000101435,CTA,20565543,"Evolution and human tissue expression of the Cres/Testatin subgroup genes, a reproductive tissue specific subgroup of the type 2 cystatins.",2010,10.1111/j.1525-142x.2010.00418.x,https://pubmed.ncbi.nlm.nih.gov/20565543/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9L,ENSG00000101435,CTA,11756564,Isolation of the human testatin gene and analysis in patients with abnormal gonadal development.,2002,10.1093/molehr/8.1.8,https://pubmed.ncbi.nlm.nih.gov/11756564/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A2,ENSG00000271449,CTA,31322286,Ursolic acid promotes apoptosis and mediates transcriptional suppression of CT45A2 gene expression in non-small-cell lung carcinoma harbouring EGFR T790M mutations.,2019,10.1111/bph.14793,https://pubmed.ncbi.nlm.nih.gov/31322286/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A2,ENSG00000271449,CTA,39933391,"A computer-aided, carrier-free drug delivery system with enhanced cytotoxicity and biocompatibility: A universal model for multifunctional lung cancer therapy.",2025,10.1016/j.colsurfb.2025.114557,https://pubmed.ncbi.nlm.nih.gov/39933391/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A2,ENSG00000271449,CTA,20920256,A novel spliced fusion of MLL with CT45A2 in a pediatric biphenotypic acute leukemia.,2010,10.1186/1471-2407-10-518,https://pubmed.ncbi.nlm.nih.gov/20920256/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A2,ENSG00000271449,CTA,22846743,Genetic and clinical characterization of 45 acute leukemia patients with MLL gene rearrangements from a single institution.,2012,10.1016/j.molonc.2012.06.004,https://pubmed.ncbi.nlm.nih.gov/22846743/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A2,ENSG00000271449,CTA,15905330,Identification of cancer/testis-antigen genes by massively parallel signature sequencing.,2005,10.1073/pnas.0502583102,https://pubmed.ncbi.nlm.nih.gov/15905330/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A7,ENSG00000273696,CTA,15905330,Identification of cancer/testis-antigen genes by massively parallel signature sequencing.,2005,10.1073/pnas.0502583102,https://pubmed.ncbi.nlm.nih.gov/15905330/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT47A1,ENSG00000236371,CTA,37866660,Comprehensive analysis of cuproptosis genes and cuproptosis-related genes as prognosis factors in esophageal squamous cell carcinoma.,2023,10.1016/j.ygeno.2023.110732,https://pubmed.ncbi.nlm.nih.gov/37866660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT47A1,ENSG00000236371,CTA,16382448,"Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome.",2006,10.1002/gcc.20298,https://pubmed.ncbi.nlm.nih.gov/16382448/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT47A10,ENSG00000224089,CTA,16382448,"Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome.",2006,10.1002/gcc.20298,https://pubmed.ncbi.nlm.nih.gov/16382448/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT47A11,ENSG00000226929,CTA,16382448,"Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome.",2006,10.1002/gcc.20298,https://pubmed.ncbi.nlm.nih.gov/16382448/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT47A12,ENSG00000226685,CTA,16382448,"Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome.",2006,10.1002/gcc.20298,https://pubmed.ncbi.nlm.nih.gov/16382448/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT47A2,ENSG00000242362,CTA,16382448,"Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome.",2006,10.1002/gcc.20298,https://pubmed.ncbi.nlm.nih.gov/16382448/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT47A3,ENSG00000236126,CTA,16382448,"Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome.",2006,10.1002/gcc.20298,https://pubmed.ncbi.nlm.nih.gov/16382448/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT47A4,ENSG00000230594,CTA,16382448,"Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome.",2006,10.1002/gcc.20298,https://pubmed.ncbi.nlm.nih.gov/16382448/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT47A5,ENSG00000237957,CTA,16382448,"Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome.",2006,10.1002/gcc.20298,https://pubmed.ncbi.nlm.nih.gov/16382448/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT47A6,ENSG00000226023,CTA,16382448,"Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome.",2006,10.1002/gcc.20298,https://pubmed.ncbi.nlm.nih.gov/16382448/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT47A7,ENSG00000228517,CTA,16382448,"Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome.",2006,10.1002/gcc.20298,https://pubmed.ncbi.nlm.nih.gov/16382448/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT47A8,ENSG00000230347,CTA,16382448,"Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome.",2006,10.1002/gcc.20298,https://pubmed.ncbi.nlm.nih.gov/16382448/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT47A9,ENSG00000226600,CTA,16382448,"Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome.",2006,10.1002/gcc.20298,https://pubmed.ncbi.nlm.nih.gov/16382448/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT55,ENSG00000169551,CTA,36481789,Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.,2023,10.1038/s41418-022-01098-6,https://pubmed.ncbi.nlm.nih.gov/36481789/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT55,ENSG00000169551,CTA,35189384,Cancer/Testis Antigen 55 is required for cancer cell proliferation and mitochondrial DNA maintenance.,2022,10.1016/j.mito.2022.02.005,https://pubmed.ncbi.nlm.nih.gov/35189384/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT55,ENSG00000169551,CTA,33023190,Characteristics of a Novel Target Antigen Against Myeloma Cells for Immunotherapy.,2020,10.3390/vaccines8040579,https://pubmed.ncbi.nlm.nih.gov/33023190/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT55,ENSG00000169551,CTA,30944312,Cancer testis antigen 55 deficiency attenuates colitis-associated colorectal cancer by inhibiting NF-κB signaling.,2019,10.1038/s41419-019-1537-x,https://pubmed.ncbi.nlm.nih.gov/30944312/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT55,ENSG00000169551,CTA,28862699,CXorf48 is a potential therapeutic target for achieving treatment-free remission in CML patients.,2017,10.1038/bcj.2017.84,https://pubmed.ncbi.nlm.nih.gov/28862699/,normal | therapy,Discussed in explicit gene adjudication; see its review depth and limitations
CT55,ENSG00000169551,CTA,35651938,Identification of Novel Characteristics in TP53-Mutant Hepatocellular Carcinoma Using Bioinformatics.,2022,10.3389/fgene.2022.874805,https://pubmed.ncbi.nlm.nih.gov/35651938/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT55,ENSG00000169551,CTA,25564441,A Comprehensive Expression Analysis of Cancer Testis Antigens in Head and Neck Squamous Cell Carcinoma Revels MAGEA3/6 as a Marker for Recurrence.,2015,10.1158/1535-7163.mct-14-0796,https://pubmed.ncbi.nlm.nih.gov/25564441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT55,ENSG00000169551,CTA,15499386,"BJ-HCC-20, a potential novel cancer-testis antigen.",2004,10.1139/o04-056,https://pubmed.ncbi.nlm.nih.gov/15499386/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,42674724,Association Between Kita-Kyushu Lung Cancer Antigen-1 Positivity and Pathological High-grade Lung Adenocarcinoma.,2026,10.21873/anticanres.18353,https://pubmed.ncbi.nlm.nih.gov/42674724/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,41082823,Sandwich immunoassay for evaluation of serum Kita-Kyushu Lung Cancer Antigen-1 as a potential diagnostic biomarker for gastric cancer.,2025,10.1016/j.tranon.2025.102566,https://pubmed.ncbi.nlm.nih.gov/41082823/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,41608347,Kita-Kyushu lung cancer antigen-1 expression in initial gastric tumors predicts multiple cancer development: A pilot study.,2026,10.5306/wjco.v17.i1.113612,https://pubmed.ncbi.nlm.nih.gov/41608347/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,41558812,Non-superagonist CD28-based dual-signal T cell engager targeting.,2026,10.1136/jitc-2025-013246,https://pubmed.ncbi.nlm.nih.gov/41558812/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,40155017,Association Between Kita-kyushu Lung Cancer Antigen-1 Expression in Gastric Cancer and Helicobacter pylori-infection Status.,2025,10.21873/anticanres.17541,https://pubmed.ncbi.nlm.nih.gov/40155017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,40141328,CT83 Promotes Cancer Progression by Upregulation of PDL1 in Adenocarcinoma of the Cervix.,2025,10.3390/ijms26062687,https://pubmed.ncbi.nlm.nih.gov/40141328/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,40521510,"Discovery and Exploration of Small Molecule Binders for CT83: Computational Insights from Homology Modeling, Virtual Screening, MD Simulations, Interaction Fingerprint, and Network Communications.",2025,10.1021/acsomega.5c00053,https://pubmed.ncbi.nlm.nih.gov/40521510/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,41062176,Novel tetrameric bispecific KK-LC-1×CD16A-armed memory-like NK cells enhance antitumor efficacy in gastric cancer.,2025,10.1136/jitc-2025-012504,https://pubmed.ncbi.nlm.nih.gov/41062176/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,41500040,Functional and structural analysis of KK-LC-1-specific T cell receptors from patients with lung Cancer for immunotherapy.,2026,10.1016/j.cellimm.2025.105059,https://pubmed.ncbi.nlm.nih.gov/41500040/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,38972967,"KK-LC-1, a biomarker for prognosis of immunotherapy for primary liver cancer.",2024,10.1186/s12885-024-12586-y,https://pubmed.ncbi.nlm.nih.gov/38972967/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,36484013,"Detection of Kita-Kyushu Lung Cancer Antigen-1, a Cancer/Testis Antigen, in the Stomach Close to a Cancerous Condition.",2022,10.7150/jca.67534,https://pubmed.ncbi.nlm.nih.gov/36484013/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,40152485,"Expression of Cancer-Testis Antigens MAGE-A1, MAGE-A4, NY-ESO-1 and PRAME in Bone and Soft Tissue Sarcomas: The Experience From a Single Center in China.",2025,10.1002/cam4.70750,https://pubmed.ncbi.nlm.nih.gov/40152485/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,34917263,Molecular characterization of Kita-Kyushu lung cancer antigen (KK-LC-1) expressing carcinomas.,2021,10.18632/oncotarget.28132,https://pubmed.ncbi.nlm.nih.gov/34917263/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,35907786,Cancer-testis antigen KK-LC-1 is a potential biomarker associated with immune cell infiltration in lung adenocarcinoma.,2022,10.1186/s12885-022-09930-5,https://pubmed.ncbi.nlm.nih.gov/35907786/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,39864021,"A panel of cancer testis antigens in squamous cell carcinoma of the lung, head and neck, and esophagus: implication for biomarkers and therapeutic targets.",2025,10.1007/s12672-025-01804-z,https://pubmed.ncbi.nlm.nih.gov/39864021/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,37610673,Expression of four cancer-testis antigens in TNBC indicating potential universal immunotherapeutic targets.,2023,10.1007/s00432-023-05274-0,https://pubmed.ncbi.nlm.nih.gov/37610673/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,38467851,A novel bioinformatic approach reveals cooperation between Cancer/Testis genes in basal-like breast tumors.,2024,10.1038/s41388-024-03002-7,https://pubmed.ncbi.nlm.nih.gov/38467851/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,36895039,Targeting KK-LC-1 inhibits malignant biological behaviors of triple-negative breast cancer.,2023,10.1186/s12967-023-04030-9,https://pubmed.ncbi.nlm.nih.gov/36895039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,37147285,KK-LC-1 as a therapeutic target to eliminate ALDH+ stem cells in triple negative breast cancer.,2023,10.1038/s41467-023-38097-1,https://pubmed.ncbi.nlm.nih.gov/37147285/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,31455429,Cancer targeting by TCR gene-engineered T cells directed against Kita-Kyushu Lung Cancer Antigen-1.,2019,10.1186/s40425-019-0678-x,https://pubmed.ncbi.nlm.nih.gov/31455429/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,42870779,"Cellular immunotherapy for lung cancer: current clinical evidence, translational challenges, and future perspectives: a narrative review.",2026,10.21037/tcr-2026-1627,https://pubmed.ncbi.nlm.nih.gov/42870779/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,41611247,Correction: Non-superagonist CD28-based dual-signal T cell engager targeting KK-LC-1 enhances antitumor efficacy.,2026,10.1136/jitc-2025-013246corr1,https://pubmed.ncbi.nlm.nih.gov/41611247/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,35855340,Kita-Kyushu Lung Cancer Antigen-1 (KK-LC-1): A Promising Cancer Testis Antigen.,2022,10.14336/ad.2021.1207,https://pubmed.ncbi.nlm.nih.gov/35855340/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,35116371,Relationship between Kita-Kyushu Lung Cancer antigen-1 expression and prognosis of cases with lung squamous cell carcinoma.,2021,10.21037/tcr-21-1581,https://pubmed.ncbi.nlm.nih.gov/35116371/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT83,ENSG00000204019,CTA,16651449,"Identification of a new cancer/germline gene, KK-LC-1, encoding an antigen recognized by autologous CTL induced on human lung adenocarcinoma.",2006,10.1158/0008-5472.can-05-3840,https://pubmed.ncbi.nlm.nih.gov/16651449/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,41846058,"NY-ESO-1 in Triple-Negative Breast Cancer: Systematic Review, Meta-Analysis, and Immunotherapeutic Implications.",2026,10.1016/j.intimp.2026.116459,https://pubmed.ncbi.nlm.nih.gov/41846058/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,40802116,Immunotherapeutic targeting of NY-ESO-1 in malignant meningiomas with TCR-transduced T-cells.,2025,10.1007/s11060-025-05200-z,https://pubmed.ncbi.nlm.nih.gov/40802116/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,42118259,NY-ESO-1 and PD-L1 as biomarkers associated with nivolumab response and outcome in unresectable or recurrent esophageal squamous cell carcinoma: a multicenter biomarker study.,2026,10.1007/s00262-026-04415-x,https://pubmed.ncbi.nlm.nih.gov/42118259/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,41469101,Self-differentiated Dendritic Cells Presenting NY-ESO-1 Prime Cytotoxic T Cells for the Treatment of Multiple Myeloma.,2026,10.21873/anticanres.17939,https://pubmed.ncbi.nlm.nih.gov/41469101/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,42827984,CAR T cell-induced interferon gamma enhances MHC class I expression and sensitizes neuroblastoma to TCR-engineered T cell therapy.,2026,10.3389/fimmu.2026.1901504,https://pubmed.ncbi.nlm.nih.gov/42827984/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,42245734,Intratumoral TLR4 agonist therapy elicits antigen-specific T cell clonal expansion in metastatic leiomyosarcoma: a case series.,2026,10.3389/fonc.2026.1829331,https://pubmed.ncbi.nlm.nih.gov/42245734/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,41053024,NY-ESO-1 facilitates anoikis resistance and tumor metastasis by hijacking deubiquitinase OTUB1 to stabilize PP1α.,2025,10.1038/s41419-025-08017-w,https://pubmed.ncbi.nlm.nih.gov/41053024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,40865252,An indirect ELISA for the detection of anti-NY-ESO-1 antibodies in cancer patients and for monitoring cancer therapy.,2025,10.1016/j.molimm.2025.08.009,https://pubmed.ncbi.nlm.nih.gov/40865252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,40873562,Mechanism of action of over-expressing NY-ESO-1 in vesicular stomatitis virus and its combination therapy with NY-ESO-1 TCR-T.,2025,10.3389/fimmu.2025.1617941,https://pubmed.ncbi.nlm.nih.gov/40873562/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,42906236,Internalizing RGD (iRGD)-modified liposomal nanoparticles as a universal antigen-delivering platform for remodeling tumors and enhancing T-cell receptor-engineered T cell immunotherapy.,2026,10.1016/j.colsurfb.2026.116266,https://pubmed.ncbi.nlm.nih.gov/42906236/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,40395161,"Correction to ""Expression of Cancer-Testis Antigens MAGE-A1, MAGE-A4, NY-ESO-1 and PRAME in Bone and Soft Tissue Sarcomas: The Experience From a Single Center in China"".",2025,10.1002/cam4.70971,https://pubmed.ncbi.nlm.nih.gov/40395161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,40445421,Stabilized iRGD modification enhances NY-ESO-1 TCR-T infiltration in solid tumors and synergizes with PD-1 blockade.,2025,10.1007/s00262-025-04077-1,https://pubmed.ncbi.nlm.nih.gov/40445421/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,41132970,NY-ESO-1 targeting in non-small cell lung cancer: promise and challenges of letetresgene autoleucel.,2025,10.21037/tlcr-2025-625,https://pubmed.ncbi.nlm.nih.gov/41132970/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,41760259,"Immunohistochemical Expression and Clinicopathological Assessment of PD-1, PD-L1, NY-ESO-1, and MAGE-A4 Expression in Desmoid Tumor.",2026,10.21873/anticanres.18037,https://pubmed.ncbi.nlm.nih.gov/41760259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,40577481,Engineered CD4 TCR T cells with conserved high-affinity TCRs targeting NY-ESO-1 for advanced cellular therapies in cancer.,2025,10.1126/sciadv.adu5754,https://pubmed.ncbi.nlm.nih.gov/40577481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,42753002,Cancer-Testis Antigens in Immuno Oncology Mechanisms Therapeutic Strategies and Clinical Perspectives.,2026,10.1155/jimr/8131644,https://pubmed.ncbi.nlm.nih.gov/42753002/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,40152485,"Expression of Cancer-Testis Antigens MAGE-A1, MAGE-A4, NY-ESO-1 and PRAME in Bone and Soft Tissue Sarcomas: The Experience From a Single Center in China.",2025,10.1002/cam4.70750,https://pubmed.ncbi.nlm.nih.gov/40152485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,40054461,"Phase 1 study of IMCnyeso, a T cell receptor bispecific ImmTAC targeting NY-ESO-1-expressing malignancies.",2025,10.1016/j.xcrm.2025.101994,https://pubmed.ncbi.nlm.nih.gov/40054461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,42419156,The cancer/testis antigens represent promising targets for the development of new therapies against melanoma.,2026,10.1016/j.prp.2026.156617,https://pubmed.ncbi.nlm.nih.gov/42419156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,42617602,Scalable generation of hematopoietic stem cell-engineered off-the-shelf mono-specific cytotoxic T cells targeting solid tumors.,2026,10.1016/j.xcrm.2026.102998,https://pubmed.ncbi.nlm.nih.gov/42617602/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,42870779,"Cellular immunotherapy for lung cancer: current clinical evidence, translational challenges, and future perspectives: a narrative review.",2026,10.21037/tcr-2026-1627,https://pubmed.ncbi.nlm.nih.gov/42870779/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,42773579,Modular mRNA cocktail enables synergistic activation of antigen-specific T cells for cancer immunotherapy.,2026,10.1080/2162402x.2026.2736339,https://pubmed.ncbi.nlm.nih.gov/42773579/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,39275923,NY-ESO-1 antigen: A promising frontier in cancer immunotherapy.,2024,10.1002/ctm2.70020,https://pubmed.ncbi.nlm.nih.gov/39275923/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,41309872,In silico design of a multi-epitope vaccine against the triple negative breast cancer.,2025,10.1038/s41598-025-26511-1,https://pubmed.ncbi.nlm.nih.gov/41309872/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,42619491,AlphaFold 3 prediction of TCR mimic Fv - pMHC complex structures and their validation and optimization.,2026,10.1080/19420862.2026.2719263,https://pubmed.ncbi.nlm.nih.gov/42619491/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,41281658,Engineered &lt;i&gt;Lactococcus lactis&lt;/i&gt; biovaccine containing NY-ESO-1 long peptides as potent immunotherapeutics.,2025,10.1016/j.mtbio.2025.102440,https://pubmed.ncbi.nlm.nih.gov/41281658/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,40809194,Checkpoint immunotherapy is associated with preferential activation of tumor antigen-specific CD4&lt;sup&gt;+&lt;/sup&gt; T cells in MDS.,2025,10.1016/j.bneo.2025.100106,https://pubmed.ncbi.nlm.nih.gov/40809194/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,42594762,iPSC-derived polyvalent vaccines as ontogenetically informed immunogens toward overcoming immune refractoriness in microsatellite-stable colorectal cancer: An emerging frontier in cancer immunotherapy.,2026,10.1016/j.molimm.2026.08.008,https://pubmed.ncbi.nlm.nih.gov/42594762/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1A,ENSG00000268651,CTA,12065688,"The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ.",2002,10.1097/01.lab.0000017169.26718.5f,https://pubmed.ncbi.nlm.nih.gov/12065688/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,41846058,"NY-ESO-1 in Triple-Negative Breast Cancer: Systematic Review, Meta-Analysis, and Immunotherapeutic Implications.",2026,10.1016/j.intimp.2026.116459,https://pubmed.ncbi.nlm.nih.gov/41846058/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,40802116,Immunotherapeutic targeting of NY-ESO-1 in malignant meningiomas with TCR-transduced T-cells.,2025,10.1007/s11060-025-05200-z,https://pubmed.ncbi.nlm.nih.gov/40802116/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,42118259,NY-ESO-1 and PD-L1 as biomarkers associated with nivolumab response and outcome in unresectable or recurrent esophageal squamous cell carcinoma: a multicenter biomarker study.,2026,10.1007/s00262-026-04415-x,https://pubmed.ncbi.nlm.nih.gov/42118259/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,41469101,Self-differentiated Dendritic Cells Presenting NY-ESO-1 Prime Cytotoxic T Cells for the Treatment of Multiple Myeloma.,2026,10.21873/anticanres.17939,https://pubmed.ncbi.nlm.nih.gov/41469101/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,42827984,CAR T cell-induced interferon gamma enhances MHC class I expression and sensitizes neuroblastoma to TCR-engineered T cell therapy.,2026,10.3389/fimmu.2026.1901504,https://pubmed.ncbi.nlm.nih.gov/42827984/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,42245734,Intratumoral TLR4 agonist therapy elicits antigen-specific T cell clonal expansion in metastatic leiomyosarcoma: a case series.,2026,10.3389/fonc.2026.1829331,https://pubmed.ncbi.nlm.nih.gov/42245734/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,41053024,NY-ESO-1 facilitates anoikis resistance and tumor metastasis by hijacking deubiquitinase OTUB1 to stabilize PP1α.,2025,10.1038/s41419-025-08017-w,https://pubmed.ncbi.nlm.nih.gov/41053024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,40865252,An indirect ELISA for the detection of anti-NY-ESO-1 antibodies in cancer patients and for monitoring cancer therapy.,2025,10.1016/j.molimm.2025.08.009,https://pubmed.ncbi.nlm.nih.gov/40865252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,40873562,Mechanism of action of over-expressing NY-ESO-1 in vesicular stomatitis virus and its combination therapy with NY-ESO-1 TCR-T.,2025,10.3389/fimmu.2025.1617941,https://pubmed.ncbi.nlm.nih.gov/40873562/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,42906236,Internalizing RGD (iRGD)-modified liposomal nanoparticles as a universal antigen-delivering platform for remodeling tumors and enhancing T-cell receptor-engineered T cell immunotherapy.,2026,10.1016/j.colsurfb.2026.116266,https://pubmed.ncbi.nlm.nih.gov/42906236/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,40395161,"Correction to ""Expression of Cancer-Testis Antigens MAGE-A1, MAGE-A4, NY-ESO-1 and PRAME in Bone and Soft Tissue Sarcomas: The Experience From a Single Center in China"".",2025,10.1002/cam4.70971,https://pubmed.ncbi.nlm.nih.gov/40395161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,40445421,Stabilized iRGD modification enhances NY-ESO-1 TCR-T infiltration in solid tumors and synergizes with PD-1 blockade.,2025,10.1007/s00262-025-04077-1,https://pubmed.ncbi.nlm.nih.gov/40445421/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,41132970,NY-ESO-1 targeting in non-small cell lung cancer: promise and challenges of letetresgene autoleucel.,2025,10.21037/tlcr-2025-625,https://pubmed.ncbi.nlm.nih.gov/41132970/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,41760259,"Immunohistochemical Expression and Clinicopathological Assessment of PD-1, PD-L1, NY-ESO-1, and MAGE-A4 Expression in Desmoid Tumor.",2026,10.21873/anticanres.18037,https://pubmed.ncbi.nlm.nih.gov/41760259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,40577481,Engineered CD4 TCR T cells with conserved high-affinity TCRs targeting NY-ESO-1 for advanced cellular therapies in cancer.,2025,10.1126/sciadv.adu5754,https://pubmed.ncbi.nlm.nih.gov/40577481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,40902852,Digital Spatial Profiling Demonstrates Differences Between Fibrosarcomatous Transformation of Dermatofibrosarcoma Protuberans and Its Conventional Counterparts.,2025,10.1016/j.modpat.2025.100879,https://pubmed.ncbi.nlm.nih.gov/40902852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,42753002,Cancer-Testis Antigens in Immuno Oncology Mechanisms Therapeutic Strategies and Clinical Perspectives.,2026,10.1155/jimr/8131644,https://pubmed.ncbi.nlm.nih.gov/42753002/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,40152485,"Expression of Cancer-Testis Antigens MAGE-A1, MAGE-A4, NY-ESO-1 and PRAME in Bone and Soft Tissue Sarcomas: The Experience From a Single Center in China.",2025,10.1002/cam4.70750,https://pubmed.ncbi.nlm.nih.gov/40152485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,40054461,"Phase 1 study of IMCnyeso, a T cell receptor bispecific ImmTAC targeting NY-ESO-1-expressing malignancies.",2025,10.1016/j.xcrm.2025.101994,https://pubmed.ncbi.nlm.nih.gov/40054461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,42419156,The cancer/testis antigens represent promising targets for the development of new therapies against melanoma.,2026,10.1016/j.prp.2026.156617,https://pubmed.ncbi.nlm.nih.gov/42419156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,42870779,"Cellular immunotherapy for lung cancer: current clinical evidence, translational challenges, and future perspectives: a narrative review.",2026,10.21037/tcr-2026-1627,https://pubmed.ncbi.nlm.nih.gov/42870779/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,42773579,Modular mRNA cocktail enables synergistic activation of antigen-specific T cells for cancer immunotherapy.,2026,10.1080/2162402x.2026.2736339,https://pubmed.ncbi.nlm.nih.gov/42773579/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,39275923,NY-ESO-1 antigen: A promising frontier in cancer immunotherapy.,2024,10.1002/ctm2.70020,https://pubmed.ncbi.nlm.nih.gov/39275923/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,42617602,Scalable generation of hematopoietic stem cell-engineered off-the-shelf mono-specific cytotoxic T cells targeting solid tumors.,2026,10.1016/j.xcrm.2026.102998,https://pubmed.ncbi.nlm.nih.gov/42617602/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,41309872,In silico design of a multi-epitope vaccine against the triple negative breast cancer.,2025,10.1038/s41598-025-26511-1,https://pubmed.ncbi.nlm.nih.gov/41309872/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,42619491,AlphaFold 3 prediction of TCR mimic Fv - pMHC complex structures and their validation and optimization.,2026,10.1080/19420862.2026.2719263,https://pubmed.ncbi.nlm.nih.gov/42619491/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,41281658,Engineered &lt;i&gt;Lactococcus lactis&lt;/i&gt; biovaccine containing NY-ESO-1 long peptides as potent immunotherapeutics.,2025,10.1016/j.mtbio.2025.102440,https://pubmed.ncbi.nlm.nih.gov/41281658/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,40809194,Checkpoint immunotherapy is associated with preferential activation of tumor antigen-specific CD4&lt;sup&gt;+&lt;/sup&gt; T cells in MDS.,2025,10.1016/j.bneo.2025.100106,https://pubmed.ncbi.nlm.nih.gov/40809194/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,42594762,iPSC-derived polyvalent vaccines as ontogenetically informed immunogens toward overcoming immune refractoriness in microsatellite-stable colorectal cancer: An emerging frontier in cancer immunotherapy.,2026,10.1016/j.molimm.2026.08.008,https://pubmed.ncbi.nlm.nih.gov/42594762/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG1B,ENSG00000184033,CTA,12065688,"The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ.",2002,10.1097/01.lab.0000017169.26718.5f,https://pubmed.ncbi.nlm.nih.gov/12065688/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,42260416,"Integrated multi-omics profiling uncovers the epigenetic, transcriptional, and metabolic landscape of prostate cancer progression.",2026,10.1186/s12885-026-16232-7,https://pubmed.ncbi.nlm.nih.gov/42260416/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,42360372,Zinc finger protein-associated gene signature serves as a potential predictor for prognosis and therapeutic response in lung adenocarcinoma.,2026,10.1007/s00726-026-03528-y,https://pubmed.ncbi.nlm.nih.gov/42360372/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,40359694,Cancer-testis antigen expression in canine melanoma and healthy tissues.,2025,10.1016/j.vetimm.2025.110946,https://pubmed.ncbi.nlm.nih.gov/40359694/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,42471478,Hypoxia-induced mechanism of TNBC promoting tumour cell proliferation through exosomal miRNA.,2026,10.1007/s00335-026-10260-1,https://pubmed.ncbi.nlm.nih.gov/42471478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,42576234,Transcriptome signatures for the identification of bevacizumab responders in ovarian cancer.,2026,10.1186/s13073-026-01727-6,https://pubmed.ncbi.nlm.nih.gov/42576234/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,38297316,BORIS/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sites.,2024,10.1186/s13059-024-03175-0,https://pubmed.ncbi.nlm.nih.gov/38297316/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,39430552,Interaction of CTCF and CTCFL in genome regulation through chromatin architecture during the spermatogenesis and carcinogenesis.,2024,10.7717/peerj.18240,https://pubmed.ncbi.nlm.nih.gov/39430552/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,36983050,A Therapeutic Vaccine Targeting Rat BORIS (CTCFL) for the Treatment of Rat Breast Cancer Tumors.,2023,10.3390/ijms24065976,https://pubmed.ncbi.nlm.nih.gov/36983050/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,39119229,Atractyloside inhibits gefitinib‑resistant non‑small‑cell lung cancer cell proliferation.,2024,10.3892/ol.2024.14599,https://pubmed.ncbi.nlm.nih.gov/39119229/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,41254162,Disentangling the architectural and non-architectural functions of CTCF and cohesin in gene regulation.,2025,10.1038/s41588-025-02404-x,https://pubmed.ncbi.nlm.nih.gov/41254162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,42335240,Fasting primes small intestinal regeneration after damage via a microbiome-metabolite-chromatin axis.,2026,10.1073/pnas.2529215123,https://pubmed.ncbi.nlm.nih.gov/42335240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,41123849,Loss of miR-122 promotes cell migration and poor prognosis in triple-negative breast cancer treated by neoadjuvant chemotherapy.,2026,10.1007/s12094-025-04082-x,https://pubmed.ncbi.nlm.nih.gov/41123849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,38500512,"Mechanism of miR-98-5p in gastric cancer cell proliferation, migration, and invasion through the USP44/CTCFL axis.",2024,10.1093/toxres/tfae040,https://pubmed.ncbi.nlm.nih.gov/38500512/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,42192951,A Zinc Finger Protein-Based Prognostic Model in Lung Adenocarcinoma Identifies FGD3 as a Marker Associated with Lorlatinib Resistance.,2026,10.3390/cancers18101591,https://pubmed.ncbi.nlm.nih.gov/42192951/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,39905312,"Exploring the role and mechanisms of MAGEA4 in tumorigenesis, regulation, and immunotherapy.",2025,10.1186/s10020-025-01079-8,https://pubmed.ncbi.nlm.nih.gov/39905312/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,42853912,Chromatin interaction landscape of epimorphic regeneration in teleost fish.,2026,10.1126/sciadv.aeh2087,https://pubmed.ncbi.nlm.nih.gov/42853912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,38810696,CTCF and BORIS-mediated autophagy regulation via alternative splicing of BNIP3L in breast cancer.,2024,10.1016/j.jbc.2024.107416,https://pubmed.ncbi.nlm.nih.gov/38810696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,36692143,Boris knockout eliminates AOM/DSS-induced in situ colorectal cancer by suppressing DNA damage repair and inflammation.,2023,10.1111/cas.15732,https://pubmed.ncbi.nlm.nih.gov/36692143/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,37235839,Association of mutation and expression of the brother of the regulator of imprinted sites (BORIS) gene with breast cancer progression.,2023,10.18632/oncotarget.28442,https://pubmed.ncbi.nlm.nih.gov/37235839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,30390146,Targeting CTCFL/BORIS for the immunotherapy of cancer.,2018,10.1007/s00262-018-2251-8,https://pubmed.ncbi.nlm.nih.gov/30390146/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,35813346,Establishment and evaluation of cell and animal models expressing BORIS subfamily 2 variant.,2022,10.21037/atm-21-6336,https://pubmed.ncbi.nlm.nih.gov/35813346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,42906437,Dietary supplementation with RG92 improves laying performance and egg quality in laying hens.,2026,10.1016/j.psj.2026.107972,https://pubmed.ncbi.nlm.nih.gov/42906437/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,37026005,PRAME and CTCFL-reactive TCRs for the treatment of ovarian cancer.,2023,10.3389/fimmu.2023.1121973,https://pubmed.ncbi.nlm.nih.gov/37026005/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,35132075,CTCFL regulates the PI3K-Akt pathway and it is a target for personalized ovarian cancer therapy.,2022,10.1038/s41540-022-00214-z,https://pubmed.ncbi.nlm.nih.gov/35132075/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,35918747,BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer.,2022,10.1186/s12943-022-01621-w,https://pubmed.ncbi.nlm.nih.gov/35918747/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,41176658,Intersection of Black race and carbohydrate antigen 19-9 nonproduction underpins worse pathologic response to neoadjuvant therapy in pancreatic cancer.,2025,10.1002/cncr.70130,https://pubmed.ncbi.nlm.nih.gov/41176658/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,33437360,"Expression profile of ACTL8, CTCFL, OIP5 and XAGE3 in glioma and their prognostic significance: a retrospective clinical study.",2020,,https://pubmed.ncbi.nlm.nih.gov/33437360/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,41193524,Emerging interest in science during early childhood period and evaluating its effectiveness.,2025,10.1038/s41598-025-22513-1,https://pubmed.ncbi.nlm.nih.gov/41193524/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTCFL,ENSG00000124092,CTA,34848739,Immunoprotective effect of an in silico designed multiepitope cancer vaccine with BORIS cancer-testis antigen target in a murine mammary carcinoma model.,2021,10.1038/s41598-021-01770-w,https://pubmed.ncbi.nlm.nih.gov/34848739/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXorf66,ENSG00000203933,CTA,35164824,"Identification of an SRY-negative 46,XX infertility male with a heterozygous deletion downstream of SOX3 gene.",2022,10.1186/s13039-022-00580-7,https://pubmed.ncbi.nlm.nih.gov/35164824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXorf66,ENSG00000203933,CTA,24709545,A novel transmembrane glycoprotein cancer biomarker present in the X chromosome.,2014,,https://pubmed.ncbi.nlm.nih.gov/24709545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC1,ENSG00000183035,CTA,41075067,Novel CYLC1 variants are associated with male infertility due to sperm head deformity.,2025,10.1007/s10815-025-03665-5,https://pubmed.ncbi.nlm.nih.gov/41075067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC1,ENSG00000183035,CTA,38573307,"Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice.",2024,10.7554/elife.95054,https://pubmed.ncbi.nlm.nih.gov/38573307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC1,ENSG00000183035,CTA,38013430,Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human.,2023,10.7554/elife.86100,https://pubmed.ncbi.nlm.nih.gov/38013430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC1,ENSG00000183035,CTA,35737091,Whole-exome sequencing of Indian prostate cancer reveals a novel therapeutic target: POLQ.,2023,10.1007/s00432-022-04111-0,https://pubmed.ncbi.nlm.nih.gov/35737091/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC1,ENSG00000183035,CTA,36896575,The human sperm proteome-Toward a panel for male fertility testing.,2023,10.1111/andr.13431,https://pubmed.ncbi.nlm.nih.gov/36896575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC1,ENSG00000183035,CTA,25786081,Differential expression of miR-499 and validation of predicted target genes in the testicular tissue of swine at different developmental stages.,2015,10.1089/dna.2014.2728,https://pubmed.ncbi.nlm.nih.gov/25786081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC1,ENSG00000183035,CTA,19679225,X chromosomal variation is associated with slow progression to AIDS in HIV-1-infected women.,2009,10.1016/j.ajhg.2009.07.013,https://pubmed.ncbi.nlm.nih.gov/19679225/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC1,ENSG00000183035,CTA,1534806,Suppression of growth factor-induced CYL1 cyclin gene expression by antiproliferative agents.,1992,10.1016/s0021-9258(19)49839-6,https://pubmed.ncbi.nlm.nih.gov/1534806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC1,ENSG00000183035,CTA,8479737,Overexpression of cyclin D1 in mouse skin carcinogenesis.,1993,,https://pubmed.ncbi.nlm.nih.gov/8479737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC1,ENSG00000183035,CTA,1382066,Selective suppression of growth factor-induced cell cycle gene expression by Na+/H+ antiport inhibitors.,1992,10.1016/s0021-9258(18)41736-x,https://pubmed.ncbi.nlm.nih.gov/1382066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC1,ENSG00000183035,CTA,1372445,Cloning of a D-type cyclin from murine erythroleukemia cells.,1992,10.1073/pnas.89.6.2444,https://pubmed.ncbi.nlm.nih.gov/1372445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC1,ENSG00000183035,CTA,1508193,Growth factor-induced delayed early response genes.,1992,10.1128/mcb.12.9.3919-3929.1992,https://pubmed.ncbi.nlm.nih.gov/1508193/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC1,ENSG00000183035,CTA,8187822,Cyclins and cyclin-dependent kinases are differentially regulated during terminal differentiation of C2C12 muscle cells.,1994,10.1006/excr.1994.1147,https://pubmed.ncbi.nlm.nih.gov/8187822/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC1,ENSG00000183035,CTA,38730249,Genetic variability of hepatitis B virus in acute and in different phases of chronic infection in Brazil.,2024,10.1038/s41598-024-60900-2,https://pubmed.ncbi.nlm.nih.gov/38730249/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC1,ENSG00000183035,CTA,8354692,"Molecular characterization of mammalian cylicin, a basic protein of the sperm head cytoskeleton.",1993,10.1083/jcb.122.5.1043,https://pubmed.ncbi.nlm.nih.gov/8354692/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC2,ENSG00000155833,CTA,38013430,Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human.,2023,10.7554/elife.86100,https://pubmed.ncbi.nlm.nih.gov/38013430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC2,ENSG00000155833,CTA,35709667,Mixed model-based eQTL analysis reveals lncRNAs associated with regulation of genes involved in sex determination and spermatogenesis: The key to understanding human gender imbalance.,2022,10.1016/j.compbiolchem.2022.107713,https://pubmed.ncbi.nlm.nih.gov/35709667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC2,ENSG00000155833,CTA,34313325,Whole genome sequencing identifies rare germline variants enriched in cancer related genes in first degree relatives of familial pancreatic cancer patients.,2021,10.1111/cge.14038,https://pubmed.ncbi.nlm.nih.gov/34313325/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC2,ENSG00000155833,CTA,26771610,Optimizing a Male Reproductive Aging Mouse Model by D-Galactose Injection.,2016,10.3390/ijms17010098,https://pubmed.ncbi.nlm.nih.gov/26771610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC2,ENSG00000155833,CTA,30297789,Typing tumors using pathways selected by somatic evolution.,2018,10.1038/s41467-018-06464-y,https://pubmed.ncbi.nlm.nih.gov/30297789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC2,ENSG00000155833,CTA,30718454,Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland.,2019,10.1038/s41398-018-0360-y,https://pubmed.ncbi.nlm.nih.gov/30718454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC2,ENSG00000155833,CTA,18340633,The mouse sperm proteome characterized via IPG strip prefractionation and LC-MS/MS identification.,2008,10.1002/pmic.200701020,https://pubmed.ncbi.nlm.nih.gov/18340633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC2,ENSG00000155833,CTA,26676054,Identification of crucial genes related to postmenopausal osteoporosis using gene expression profiling.,2016,10.1007/s40520-015-0509-y,https://pubmed.ncbi.nlm.nih.gov/26676054/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC2,ENSG00000155833,CTA,1372445,Cloning of a D-type cyclin from murine erythroleukemia cells.,1992,10.1073/pnas.89.6.2444,https://pubmed.ncbi.nlm.nih.gov/1372445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC2,ENSG00000155833,CTA,8566807,Structure and gene expression of avian cyclin D2.,1995,10.1016/0378-1119(95)00598-6,https://pubmed.ncbi.nlm.nih.gov/8566807/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYLC2,ENSG00000155833,CTA,7737358,The protein complexity of the cytoskeleton of bovine and human sperm heads: the identification and characterization of cylicin II.,1995,10.1006/excr.1995.1145,https://pubmed.ncbi.nlm.nih.gov/7737358/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,42286492,Diversity of molecular karyotypes of 234 pediatric patients with autism spectrum disorder in chromosomal microarray analysis.,2026,10.1186/s12888-026-08263-y,https://pubmed.ncbi.nlm.nih.gov/42286492/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,39198649,Sperm-origin paternal effects on root stem cell niche differentiation.,2024,10.1038/s41586-024-07885-0,https://pubmed.ncbi.nlm.nih.gov/39198649/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,35358715,Y-chromosome genes associated with sertoli cell-only syndrome identified by array comparative genome hybridization.,2023,10.1016/j.bj.2022.03.009,https://pubmed.ncbi.nlm.nih.gov/35358715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,39623270,[Plasma long noncoding RNA expression profiles in patients with Parkinson's disease and the role of lnc-CTSD-5:1 in a PD cell model: a ceRNA microarray-based study].,2024,10.12122/j.issn.1673-4254.2024.11.11,https://pubmed.ncbi.nlm.nih.gov/39623270/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,33093613,Hypomethylation of the DAZ3 promoter in idiopathic asthenospermia: a screening tool for liquid biopsy.,2020,10.1038/s41598-020-75110-9,https://pubmed.ncbi.nlm.nih.gov/33093613/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,26931020,[Association of the deleted DAZ gene copy related to gr/gr and b2/b3 deletions with spermatogenic impairment].,2016,,https://pubmed.ncbi.nlm.nih.gov/26931020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,24878370,Combined deletion of DAZ2 and DAZ4 copies of Y chromosome DAZ gene is associated with male infertility in Tunisian men.,2014,10.1016/j.gene.2014.05.061,https://pubmed.ncbi.nlm.nih.gov/24878370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,20823911,Associations of Y-chromosome subdeletion gr/gr with the prevalence of Y-chromosome haplogroups in infertile patients.,2011,10.1038/ejhg.2010.151,https://pubmed.ncbi.nlm.nih.gov/20823911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,27723784,Discrimination of Deletion and Duplication Subtypes of the Deleted in Azoospermia Gene Family in the Context of Frequent Interloci Gene Conversion.,2016,10.1371/journal.pone.0163936,https://pubmed.ncbi.nlm.nih.gov/27723784/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,14639527,A large AZFc deletion removes DAZ3/DAZ4 and nearby genes from men in Y haplogroup N.,2004,10.1086/381132,https://pubmed.ncbi.nlm.nih.gov/14639527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,17211466,"A physical analysis of the Y chromosome shows no additional deletions, other than Gr/Gr, associated with testicular germ cell tumour.",2007,10.1038/sj.bjc.6603557,https://pubmed.ncbi.nlm.nih.gov/17211466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,16963411,[Study on DAZ gene copy deletion in severe oligozoospermia sperm donor for ICSI].,2006,10.1360/yc-006-1057,https://pubmed.ncbi.nlm.nih.gov/16963411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,21837945,[Sequence tagged sites of AZFc microdeletion in Chinese Han population].,2011,,https://pubmed.ncbi.nlm.nih.gov/21837945/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,16596261,Quantitative evaluation of partial deletions of the DAZ gene cluster.,2006,10.3892/ijmm.17.5.785,https://pubmed.ncbi.nlm.nih.gov/16596261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,15520406,"Sequence family variant loss from the AZFc interval of the human Y chromosome, but not gene copy loss, is strongly associated with male infertility.",2004,10.1136/jmg.2004.022111,https://pubmed.ncbi.nlm.nih.gov/15520406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,20873591,[Partial AZfc region deletions of the Y chromosome in spermatogenic dysfunction patients].,2010,,https://pubmed.ncbi.nlm.nih.gov/20873591/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,19088127,The b2/b3 subdeletion shows higher risk of spermatogenic failure and higher frequency of complete AZFc deletion than the gr/gr subdeletion in a Chinese population.,2009,10.1093/hmg/ddn427,https://pubmed.ncbi.nlm.nih.gov/19088127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,20039973,Differential effect of specific gr/gr deletion subtypes on spermatogenesis in the Chinese Han population.,2010,10.1111/j.1365-2605.2009.01015.x,https://pubmed.ncbi.nlm.nih.gov/20039973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,17416365,AZFc partial deletions in Chilean men with severe spermatogenic failure.,2007,10.1016/j.fertnstert.2007.01.038,https://pubmed.ncbi.nlm.nih.gov/17416365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,15744033,Association of partial AZFc region deletions with spermatogenic impairment and male infertility.,2005,10.1136/jmg.2004.025833,https://pubmed.ncbi.nlm.nih.gov/15744033/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ3,ENSG00000187191,CTA,10936047,Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome.,2000,10.1006/geno.2000.6260,https://pubmed.ncbi.nlm.nih.gov/10936047/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF4L1,ENSG00000182308,CTA,28742274,Whole exome sequencing identified genetic variations in Chinese hemangioblastoma patients.,2017,10.1002/ajmg.a.38350,https://pubmed.ncbi.nlm.nih.gov/28742274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF8L2,ENSG00000189186,CTA,42913173,Maternal antibody repertoires in preeclampsia revealed by phage immunoprecipitation sequencing.,2026,10.1016/j.jaut.2026.103645,https://pubmed.ncbi.nlm.nih.gov/42913173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,40702097,Wss1 and Ddi1 DNA-Protein crosslink repair proteases protect Saccharomyces cerevisiae and Candida albicans against oxidative stress.,2025,10.1038/s41598-025-12238-6,https://pubmed.ncbi.nlm.nih.gov/40702097/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,41530178,K48-ubiquitin-dependent proteases cut-up post-ER proteins.,2026,10.1038/s41467-026-68367-7,https://pubmed.ncbi.nlm.nih.gov/41530178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,38612889,Domains in Action: Understanding Ddi1's Diverse Functions in the Ubiquitin-Proteasome System.,2024,10.3390/ijms25074080,https://pubmed.ncbi.nlm.nih.gov/38612889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,40383808,Identification and verification of a polyamine metabolism-related gene signature for predicting prognosis and immune infiltration in osteosarcoma.,2025,10.1186/s13018-025-05716-0,https://pubmed.ncbi.nlm.nih.gov/40383808/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,38011090,"Nrf1 is not a direct target gene of SREBP1, albeit both are integrated into the rapamycin-responsive regulatory network in human hepatoma cells.",2023,10.1371/journal.pone.0294508,https://pubmed.ncbi.nlm.nih.gov/38011090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,37511326,The Effects of &lt;i&gt;DDI1&lt;/i&gt; on Inducing Differentiation in Ovine Preadipocytes via Oar-miR-432.,2023,10.3390/ijms241411567,https://pubmed.ncbi.nlm.nih.gov/37511326/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,40339746,Genomic insights into the population history of fat-tailed sheep and identification of two mutations that contribute to fat tail adipogenesis.,2026,10.1016/j.jare.2025.05.011,https://pubmed.ncbi.nlm.nih.gov/40339746/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,33092996,Normal spermatogenesis and fertility in Ddi1 (DNA damage inducible 1) mutant mice.,2020,10.1016/j.repbio.2020.08.006,https://pubmed.ncbi.nlm.nih.gov/33092996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,35677776,Structural and functional insights into the DNA damage-inducible protein 1 (Ddi1) from protozoa.,2022,10.1016/j.crstbi.2022.05.003,https://pubmed.ncbi.nlm.nih.gov/35677776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,39077933,The cullin Rtt101 promotes ubiquitin-dependent DNA-protein crosslink repair across the cell cycle.,2024,10.1093/nar/gkae658,https://pubmed.ncbi.nlm.nih.gov/39077933/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,38431617,RTF2 controls replication repriming and ribonucleotide excision at the replisome.,2024,10.1038/s41467-024-45947-z,https://pubmed.ncbi.nlm.nih.gov/38431617/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,37916221,Changes in hemoglobin oxidation and band 3 during blood storage impact oxygen sensing and mitochondrial bioenergetic pathways in the human pulmonary arterial endothelial cell model.,2023,10.3389/fphys.2023.1278763,https://pubmed.ncbi.nlm.nih.gov/37916221/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,34832620,"Artemisinin Binds and Inhibits the Activity of Plasmodium falciparum Ddi1, a Retroviral Aspartyl Protease.",2021,10.3390/pathogens10111465,https://pubmed.ncbi.nlm.nih.gov/34832620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,32839439,NRIP3 upregulation confers resistance to chemoradiotherapy in ESCC via RTF2 removal by accelerating ubiquitination and degradation of RTF2.,2020,10.1038/s41389-020-00260-4,https://pubmed.ncbi.nlm.nih.gov/32839439/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,32193351,Ddi1 is a ubiquitin-dependent protease.,2020,10.1073/pnas.1902298117,https://pubmed.ncbi.nlm.nih.gov/32193351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,38408252,Proteasome condensate formation is driven by multivalent interactions with shuttle factors and ubiquitin chains.,2024,10.1073/pnas.2310756121,https://pubmed.ncbi.nlm.nih.gov/38408252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,40113723,Computational Analysis of Plasmodium falciparum DNA Damage Inducible Protein 1 (PfDdi1): Insights into Binding of Artemisinin and its Derivatives and Implications for Antimalarial Drug Design.,2025,10.1007/s12013-025-01709-2,https://pubmed.ncbi.nlm.nih.gov/40113723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,31902667,The Aspartic Protease Ddi1 Contributes to DNA-Protein Crosslink Repair in Yeast.,2020,10.1016/j.molcel.2019.12.007,https://pubmed.ncbi.nlm.nih.gov/31902667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,37144685,Ubx5-Cdc48 assists the protease Wss1 at DNA-protein crosslink sites in yeast.,2023,10.15252/embj.2023113609,https://pubmed.ncbi.nlm.nih.gov/37144685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,31130875,Detailed Dissection of UBE3A-Mediated DDI1 Ubiquitination.,2019,10.3389/fphys.2019.00534,https://pubmed.ncbi.nlm.nih.gov/31130875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,36657610,Plasmodium DDI1 is a potential therapeutic target and important chromatin-associated protein.,2023,10.1016/j.ijpara.2022.11.007,https://pubmed.ncbi.nlm.nih.gov/36657610/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,30186740,Crystal structure of the retroviral protease-like domain of a protozoal DNA damage-inducible 1 protein.,2018,10.1002/2211-5463.12491,https://pubmed.ncbi.nlm.nih.gov/30186740/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,35358511,Mammalian Ddi2 is a shuttling factor containing a retroviral protease domain that influences binding of ubiquitylated proteins and proteasomal degradation.,2022,10.1016/j.jbc.2022.101875,https://pubmed.ncbi.nlm.nih.gov/35358511/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,21266539,HIV proteinase inhibitors target the Ddi1-like protein of Leishmania parasites.,2011,10.1096/fj.10-178947,https://pubmed.ncbi.nlm.nih.gov/21266539/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDI1,ENSG00000170967,CTA,30664872,Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome.,2019,10.1016/j.jmb.2019.01.021,https://pubmed.ncbi.nlm.nih.gov/30664872/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42625859,"Dysregulation of piRNA biogenesis-associated proteins in cancer: mechanisms, evidence, and translational constraints.",2026,10.3389/fmolb.2026.1906635,https://pubmed.ncbi.nlm.nih.gov/42625859/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42589179,Intravenous Administration of Stromal Vascular Fraction Attenuates Early Busulfan-Induced Testicular Injury in Rats: An Alternative Cell-Based Approach for Spermatogenic Impairment.,2026,10.3390/biology15151312,https://pubmed.ncbi.nlm.nih.gov/42589179/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42314496,"TLE3,a transcriptional co-repressor, is dispensable for spermatogenesis and male fertility in mice.",2026,10.1016/j.theriogenology.2026.118035,https://pubmed.ncbi.nlm.nih.gov/42314496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42417195,Cap 2'-O-methyltransferase CMTR2 regulates male meiosis independent of its methyltransferase activity.,2026,10.1093/nar/gkag699,https://pubmed.ncbi.nlm.nih.gov/42417195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,41960164,Low-level lasers can improve spermatogenesis in infertile mice by targeting molecular pathways.,2026,10.34172/bi.31018,https://pubmed.ncbi.nlm.nih.gov/41960164/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42793110,Isolation and Characterization of Rabbit Spermatogonial Stem Cells as a Promising Animal Genetic Resource for Biodiversity Protection.,2026,10.3390/biom16091278,https://pubmed.ncbi.nlm.nih.gov/42793110/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,41940533,Sex-Specific Gene Expression Ontogeny During Gonadal Development in Post-Metamorphic Xenopus tropicalis.,2026,10.1002/mrd.70098,https://pubmed.ncbi.nlm.nih.gov/41940533/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42634447,Acute Dietary Zinc Deficiency Impairs Sperm Motility but Not Gonadal mRNA Methylation in Mice.,2026,10.1002/mrd.70144,https://pubmed.ncbi.nlm.nih.gov/42634447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42737821,Chemotherapy-Mediated Purging Before Testicular Organoid Generation Significantly Reduces Cancer Cells While Not Significantly Reducing Germ Cells.,2026,10.3390/ijms27177924,https://pubmed.ncbi.nlm.nih.gov/42737821/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42816322,Morphological and immunohistochemical analysis of unilateral testicular hypoplasia in an XY calf: correlation with the timing of bovine hypospadias.,2026,10.1292/jvms.26-0245,https://pubmed.ncbi.nlm.nih.gov/42816322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,40136664,"Integration of Dynamical Network Biomarkers, Control Theory and &lt;i&gt;Drosophila&lt;/i&gt; Model Identifies Vasa/DDX4 as the Potential Therapeutic Targets for Metabolic Syndrome.",2025,10.3390/cells14060415,https://pubmed.ncbi.nlm.nih.gov/40136664/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42281331,ClpP Ensures Mitochondrial Integrity and Spermatocyte Meiotic Progression in Mice.,2026,10.1111/andr.70274,https://pubmed.ncbi.nlm.nih.gov/42281331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42703821,Gene Expression Dynamics and Network Analysis Reveal Key Molecular Pathways in Spermatogenic Progression from Spermatogonial Stem Cells to Round Spermatids.,2026,10.22074/ijfs.2025.2064261.1893,https://pubmed.ncbi.nlm.nih.gov/42703821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42511771,Hexaconazole-Induced Male Reproductive Toxicity Through ROS-Mediated Ferroptosis and Impaired Leydig Cell Steroidogenesis.,2026,10.3390/ijms27146428,https://pubmed.ncbi.nlm.nih.gov/42511771/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,41708791,Targeted activation of Nrf2 via sulforaphane-loaded exosomes attenuated azoospermic condition in the rat model.,2026,10.1038/s41598-026-40709-x,https://pubmed.ncbi.nlm.nih.gov/41708791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42256297,Conserved RNA helicase Vasa regulates ribonucleoprotein condensate dynamics and mRNA localization.,2026,10.1016/j.isci.2026.116170,https://pubmed.ncbi.nlm.nih.gov/42256297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42665132,Endocrine disrupting effects of estrone on male Siniperca chuatsi: From gonadal remodeling to gene regulation.,2027,10.1016/j.jsbmb.2026.107107,https://pubmed.ncbi.nlm.nih.gov/42665132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42858619,Heat stress induces gonadal transcriptomic reprogramming and histopathological alterations in the mud crab Scylla paramamosain.,2026,10.1016/j.marpolbul.2026.120443,https://pubmed.ncbi.nlm.nih.gov/42858619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42883452,Establishment and Characterization of a Spermatogonial Stem Cell-like Line with Potential for Meiotic Differentiation in the Endangered Fish &lt;i&gt;Rhinogobio nasutus&lt;/i&gt;.,2026,10.3390/biology15191779,https://pubmed.ncbi.nlm.nih.gov/42883452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,41874152,Generation of Primordial Germ Cell-like Cells from hESCs Using BMP4 and hAFSC-Conditioned Medium.,2026,10.3390/mps9020035,https://pubmed.ncbi.nlm.nih.gov/41874152/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42462501,Protective effect of soybean isoflavone (SI) on ovarian damages by zinc oxide nanoparticles (ZnONPs) in female mice.,2026,10.1016/j.jtemb.2026.127926,https://pubmed.ncbi.nlm.nih.gov/42462501/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42726072,A verbal and social autopsy study to improve estimates of mortality determinants in Pakistan: study design and methods.,2026,10.7189/jogh.16.05004,https://pubmed.ncbi.nlm.nih.gov/42726072/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42607098,Study protocol for first national vasa previa perinatal registry.,2026,10.1371/journal.pone.0355045,https://pubmed.ncbi.nlm.nih.gov/42607098/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42202341,Revisiting vasa previa risk thresholds: integrating non-Euclidean geometry for precision in screening.,2026,10.1002/uog.70251,https://pubmed.ncbi.nlm.nih.gov/42202341/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42366763,Favoring Elective Hospitalization in Pregnancies With Vasa Previa.,2026,10.1097/grf.0000000000001041,https://pubmed.ncbi.nlm.nih.gov/42366763/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42281365,Fetoscopic laser ablation for vasa previa: caution in interpreting early experience.,2026,10.1002/uog.70262,https://pubmed.ncbi.nlm.nih.gov/42281365/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42589921,Amyloidosis and Thoracic Aortic Disease: A Scoping Review.,2026,10.3390/jcm15155817,https://pubmed.ncbi.nlm.nih.gov/42589921/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42314418,Compound probiotics alleviate aflatoxin B1-induced reproductive toxicity in mice by remodeling gut microbiota and testicular metabolome via NRF2 pathway action.,2026,10.1016/j.ecoenv.2026.120378,https://pubmed.ncbi.nlm.nih.gov/42314418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42767855,Type A acute aortic dissection associated with 5-fluorouracil: A rare but serious vascular toxicity.,2026,10.1016/j.bulcan.2026.07.010,https://pubmed.ncbi.nlm.nih.gov/42767855/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42346200,Vasa Vasorum-A Silent Enemy After EVAR: A Case Report and Review of the Literature.,2026,10.3390/clinpract16060117,https://pubmed.ncbi.nlm.nih.gov/42346200/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42484839,Safety of extensive mesenteric embolization using quick-soluble gelatin sponge particles: an experimental canine study.,2026,10.1007/s11604-026-02056-9,https://pubmed.ncbi.nlm.nih.gov/42484839/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,40271544,"Fetoscopic Laser Surgery for Vasa Previa: Feasibility, Safety, and Future Directions.",2025,10.1097/grf.0000000000000947,https://pubmed.ncbi.nlm.nih.gov/40271544/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,42726075,Exploring mortality patterns in Pakistani children and adolescents aged 5-19: evidence from a national verbal and social autopsy study.,2026,10.7189/jogh.16.04195,https://pubmed.ncbi.nlm.nih.gov/42726075/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,41127125,Ultrasound-guided caesarean section as a safer intraoperative strategy for vasa previa type III: A case report.,2025,10.1016/j.crwh.2025.e00755,https://pubmed.ncbi.nlm.nih.gov/41127125/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX4,ENSG00000152670,CTA,10920202,The human VASA gene is specifically expressed in the germ cell lineage.,2000,10.1073/pnas.160274797,https://pubmed.ncbi.nlm.nih.gov/10920202/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
DDX53,ENSG00000184735,CTA,40359694,Cancer-testis antigen expression in canine melanoma and healthy tissues.,2025,10.1016/j.vetimm.2025.110946,https://pubmed.ncbi.nlm.nih.gov/40359694/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42511500,KBN2201 Attenuates High-Fat Diet-Induced Adipose Tissue Expansion and Body Weight Gain in Male Mice.,2026,10.3390/ijms27146155,https://pubmed.ncbi.nlm.nih.gov/42511500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42825693,Context-dependent effects of whole-body vibration on reproductive function and penile tissue integrity in sedentary male rats.,2026,10.1113/ep094086,https://pubmed.ncbi.nlm.nih.gov/42825693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,39706195,Genetic variants in DDX53 contribute to autism spectrum disorder associated with the Xp22.11 locus.,2025,10.1016/j.ajhg.2024.11.003,https://pubmed.ncbi.nlm.nih.gov/39706195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42702796,Ethanol Self-Administration Reduces mGlu2/3 Protein Expression in the Nucleus Accumbens and mGlu2/3 Activation Suppresses Binge Drinking in Male Mice.,2026,10.1111/acer.70409,https://pubmed.ncbi.nlm.nih.gov/42702796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42736211,"Intestinal oxidative injury, autophagy-related alterations, and apoptosis during early cage transfer in laying ducks.",2026,10.1016/j.psj.2026.107698,https://pubmed.ncbi.nlm.nih.gov/42736211/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42866649,Genome-wide mapping of the &lt;i&gt;Galleria mellonella&lt;/i&gt; transcription start sites during fungal infection and treatment.,2026,10.1016/j.isci.2026.117675,https://pubmed.ncbi.nlm.nih.gov/42866649/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42583807,The Mechanobiology of Adipocyte Hypertrophy: Cytoskeletal Remodelling as a Driver of Insulin Resistance in Obesity.,2026,10.1002/cbf.70283,https://pubmed.ncbi.nlm.nih.gov/42583807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42737834,The CAGE Framework (Calcium-Gated Excitability): From Single Neurotransmitters to Calcium States in the Tumor Microenvironment.,2026,10.3390/ijms27177937,https://pubmed.ncbi.nlm.nih.gov/42737834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,41839849,Identification of cis-regulatory elements provides insights into tissue-specific gene regulation in the sheep genome.,2026,10.1038/s41467-026-70382-7,https://pubmed.ncbi.nlm.nih.gov/41839849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42074096,Testicular Heat-Shock Protein Expression in Rats Following 3.5 GHz and 24 GHz RF-EMF Exposure.,2026,10.3390/ijms27083452,https://pubmed.ncbi.nlm.nih.gov/42074096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42706288,Coral metabolomic diversity is associated with restoration success.,2026,10.1038/s41598-026-55229-x,https://pubmed.ncbi.nlm.nih.gov/42706288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42640025,Immune-Induced Fever and Psychogenic Hyperthermia Can Occur Independently of Uncoupling Protein 1-Mediated Brown Adipose Tissue Thermogenesis.,2026,10.1111/apha.70300,https://pubmed.ncbi.nlm.nih.gov/42640025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,41740447,Multi-tissue transcriptomic profiling reveals the internal physiological landscape of laying hens in cage and cage-free systems.,2026,10.1016/j.psj.2026.106650,https://pubmed.ncbi.nlm.nih.gov/41740447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42511453,Chronic Sleep Disturbance Enhances Inflammation and Collagen Production in Neural- and Myofascial Tissues in Uninjured Rats.,2026,10.3390/ijms27146106,https://pubmed.ncbi.nlm.nih.gov/42511453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,41922589,Multi-platform profiling reveals host- and cell -type-specific pseudorabies virus gene expression.,2026,10.1038/s41598-026-45990-4,https://pubmed.ncbi.nlm.nih.gov/41922589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42130046,On the importance of including both sexes in animal studies - insights from home-cage monitoring.,2026,10.1002/brv.70184,https://pubmed.ncbi.nlm.nih.gov/42130046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42750441,EGR3 deletion attenuates developmental and epileptic encephalopathy in Kcna1-null mice.,2026,10.1093/brain/awag319,https://pubmed.ncbi.nlm.nih.gov/42750441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42290582,Cerebral arterial oxygen embolism as a complication of hyperbaric oxygen treatment: a case report.,2026,10.28920/dhm56.2.198-202,https://pubmed.ncbi.nlm.nih.gov/42290582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,38753040,Loss-of-function mutation in DDX53 associated with hereditary spastic paraplegia-like disorder.,2024,10.1007/s00109-024-02454-4,https://pubmed.ncbi.nlm.nih.gov/38753040/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42018247,A deep dive into ferritin nanoparticle advancements: experimental and computational perspectives.,2026,10.1186/s11671-026-04577-8,https://pubmed.ncbi.nlm.nih.gov/42018247/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,41937393,I53-50: Engineered icosahedral protein cage for modular vaccine nanoplatform.,2026,10.71150/jm.2511020,https://pubmed.ncbi.nlm.nih.gov/41937393/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42889189,Peptide optimization to improve antigen presentation and antitumor responses in sarcoma.,2026,10.3389/fimmu.2026.1960095,https://pubmed.ncbi.nlm.nih.gov/42889189/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,40333202,The Application of Dendritic Cells Vaccines in Tumor Therapy and Their Combination with Biomimetic Nanoparticles.,2025,10.3390/vaccines13040337,https://pubmed.ncbi.nlm.nih.gov/40333202/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42205866,"Molecular Mechanisms and Biomedical Applications of Ferritin Nanocages: A Comprehensive Review of Self-Assembly, Engineering, and Multifunctional Delivery Platforms.",2026,10.2147/ijn.s600409,https://pubmed.ncbi.nlm.nih.gov/42205866/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42589012,Protective Effects of a Polyphenolic Fraction of Bergamot in Improving the Welfare Index in Honeybees (&lt;i&gt;Apis mellifera&lt;/i&gt;) Co-Exposed to Deltamethrin and Flupyradifurone: A Laboratory Cage Study.,2026,10.3390/ani16152374,https://pubmed.ncbi.nlm.nih.gov/42589012/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,40750422,Clinical Evaluation of Immune Cell Therapy in Esophageal Cancer Resistant to Immunochemotherapy.,2025,10.21873/anticanres.17716,https://pubmed.ncbi.nlm.nih.gov/40750422/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42561740,Antiparasitic efficacy and safety evaluation of metronidazole against Trypanosoma sp. from large yellow croaker in experimentally infected largemouth bass (Micropterus salmoides).,2026,10.1016/j.vetpar.2026.110878,https://pubmed.ncbi.nlm.nih.gov/42561740/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,41522147,Feasibility and safety of outside the cage subcostal robotic anatomical lung resections: results of a phase I clinical trial.,2025,10.21037/jtd-2025-1505,https://pubmed.ncbi.nlm.nih.gov/41522147/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42865660,"3D-printed porous titanium versus PEEK interbody cages in lumbar fusion: biomechanical rationale, clinical evidence, and emerging indications.",2026,10.3389/fbioe.2026.1952166,https://pubmed.ncbi.nlm.nih.gov/42865660/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,40616372,Safety and Toxicological Evaluation of Subunit Keyhole Limpet Hemocyanin-Loaded Lipid-PLGA Hybrid Nanoparticles (sKLH-hNPs) as a Nanocarrier for an Opioid Use Disorder Vaccine.,2025,10.1177/10915818251355948,https://pubmed.ncbi.nlm.nih.gov/40616372/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,41938028,Osteointegration and Fusion After TLIF: Trabecular Titanium Cage with SVF-Hydrogel Compared with PEEK Cage.,2026,10.52965/001c.159611,https://pubmed.ncbi.nlm.nih.gov/41938028/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42225215,"Non-invasive, home cage digital monitoring for improved safety pharmacology assessments in drug development: ICH S7A update considerations.",2026,10.1016/j.vascn.2026.108430,https://pubmed.ncbi.nlm.nih.gov/42225215/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,41971895,Three-stage anterior lumbar interbody fusion revision surgery for transforaminal lumbar interbody fusion cage retrieval: surgical steps and preliminary results.,2026,10.21037/jss-25-160,https://pubmed.ncbi.nlm.nih.gov/41971895/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,41311720,Multi-targeted pharmacological actions and nanodelivery strategies of Garcinia cambogia: from molecular mechanisms to disease treatment.,2025,10.3389/fchem.2025.1692386,https://pubmed.ncbi.nlm.nih.gov/41311720/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42812869,Traction-Induced Avulsion of an Iliocaval Venous Branch During Multilevel OLIF for Degenerative Scoliosis: Case Report.,2026,10.1002/ccr3.73011,https://pubmed.ncbi.nlm.nih.gov/42812869/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42730302,Modular Cage-Type Prosthetic Construction for Lumbar Intervertebral Reconstruction: A Computer-Aided Design-Based Geometric Design and Finite Element Analysis Study.,2026,10.7759/cureus.114416,https://pubmed.ncbi.nlm.nih.gov/42730302/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,42683048,Are Ceramic Cages an Option for Lumbar Interbody Fusion? A Comparative Biomechanical Numerical Study.,2026,10.1002/jsp2.70215,https://pubmed.ncbi.nlm.nih.gov/42683048/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX53,ENSG00000184735,CTA,11922625,Identification and characterization of a novel cancer/testis antigen gene CAGE.,2002,10.1006/bbrc.2002.6701,https://pubmed.ncbi.nlm.nih.gov/11922625/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB123,ENSG00000180424,CTA,39265281,Yak DEFB123 alleviates lung injury caused by Klebsiella pneumoniae through MAPKs signaling pathway.,2024,10.1016/j.vetmic.2024.110248,https://pubmed.ncbi.nlm.nih.gov/39265281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB123,ENSG00000180424,CTA,38745232,Single-cell and spatial transcriptomic investigation reveals the spatiotemporal specificity of the beta-defensin gene family during mouse sperm maturation.,2024,10.1186/s12964-024-01637-3,https://pubmed.ncbi.nlm.nih.gov/38745232/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB123,ENSG00000180424,CTA,40221769,"Single nucleotide polymorphisms, gene expression and evaluation of immunological, antioxidant, and pathological parameters associated with bacterial pneumonia in Barki sheep.",2025,10.1186/s13620-025-00296-1,https://pubmed.ncbi.nlm.nih.gov/40221769/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB123,ENSG00000180424,CTA,34347114,Gene expression microarray analysis of adult testicular germ cell tumor: a comparison between pure-type seminomas and seminoma components in mixed tumors.,2021,10.1007/s00428-021-03168-5,https://pubmed.ncbi.nlm.nih.gov/34347114/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB123,ENSG00000180424,CTA,36368116,Comparative transcriptome analysis in the caput segment of yak and cattleyak epididymis.,2023,10.1016/j.theriogenology.2022.10.039,https://pubmed.ncbi.nlm.nih.gov/36368116/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB123,ENSG00000180424,CTA,33489929,Challenge of Bovine Foot Skin Fibroblasts With Digital Dermatitis Treponemes Identifies Distinct Pathogenic Mechanisms.,2020,10.3389/fcimb.2020.538591,https://pubmed.ncbi.nlm.nih.gov/33489929/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB123,ENSG00000180424,CTA,15772680,"Identification, characterization, and evolution of a primate beta-defensin gene cluster.",2005,10.1038/sj.gene.6364184,https://pubmed.ncbi.nlm.nih.gov/15772680/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,40276191,Beta-defensin 126 (DEFB126) localization and expression in the sperms and male reproductive tract of the dromedary camel (&lt;i&gt;Camelus dromedarius&lt;/i&gt;) during the rutting season.,2025,10.5455/ovj.2025.v15.i3.12,https://pubmed.ncbi.nlm.nih.gov/40276191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,41009021,Novel Hybrid Peptide DEFB126 (1-39)-TP5 Inhibits LPS-Induced Inflammatory Responses and Oxidative Stress by Neutralizing LPS and Blocking the TLR4/MD2-NFκB Signaling Axis.,2025,10.3390/antiox14091117,https://pubmed.ncbi.nlm.nih.gov/41009021/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,41890232,Promoter hypomethylation of &lt;i&gt;CDH7&lt;/i&gt;: a novel epigenetic marker associated with cerebral small vessel disease.,2026,10.3389/fgene.2026.1780415,https://pubmed.ncbi.nlm.nih.gov/41890232/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,39157277,DEFB126 2-nt Deletion (rs11467417) as a Potential Risk Factor for Chlamydia Trachomatis Infection and Subsequent Infertility in Iranian Men.,2024,10.18502/jri.v25i1.15195,https://pubmed.ncbi.nlm.nih.gov/39157277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,38745232,Single-cell and spatial transcriptomic investigation reveals the spatiotemporal specificity of the beta-defensin gene family during mouse sperm maturation.,2024,10.1186/s12964-024-01637-3,https://pubmed.ncbi.nlm.nih.gov/38745232/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,35381696,DEFB126 polymorphisms and association with idiopathic asthenozoospermia in China.,2022,10.4103/aja2021115,https://pubmed.ncbi.nlm.nih.gov/35381696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,39127975,Genetic Features of Tongue Cancer Recurrence in Young Adults.,2024,10.1007/s10517-024-06189-7,https://pubmed.ncbi.nlm.nih.gov/39127975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,37161430,Integrated bioinformatics analysis for conducting a prognostic model and identifying immunotherapeutic targets in gastric cancer.,2023,10.1186/s12859-023-05312-1,https://pubmed.ncbi.nlm.nih.gov/37161430/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,35330821,Gingival Transcriptome of Innate Antimicrobial Factors and the Oral Microbiome With Aging and Periodontitis.,2022,10.3389/froh.2022.817249,https://pubmed.ncbi.nlm.nih.gov/35330821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,31504198,Beta-defensin126 is correlated with sperm motility in fertile and infertile men†.,2020,10.1093/biolre/ioz171,https://pubmed.ncbi.nlm.nih.gov/31504198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,31474436,The role of DEFB126 variation in male infertility and medically assisted reproduction technique outcome.,2019,10.1016/j.rbmo.2019.05.012,https://pubmed.ncbi.nlm.nih.gov/31474436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,38577455,Construction of an immune-related gene signature for overall survival prediction and immune infiltration in gastric cancer.,2024,10.4251/wjgo.v16.i3.919,https://pubmed.ncbi.nlm.nih.gov/38577455/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,32030088,Comparative RNA-Seq Analysis of Differentially Expressed Genes in the Epididymides of Yak and Cattleyak.,2019,10.2174/1389202920666190809092819,https://pubmed.ncbi.nlm.nih.gov/32030088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,25721098,Another functional frame-shift polymorphism of DEFB126 (rs11467497) associated with male infertility.,2015,10.1111/jcmm.12502,https://pubmed.ncbi.nlm.nih.gov/25721098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,33547328,Sperm DNA methylation mediates the association of male age on reproductive outcomes among couples undergoing infertility treatment.,2021,10.1038/s41598-020-80857-2,https://pubmed.ncbi.nlm.nih.gov/33547328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,31841391,Acidosis induces antimicrobial peptide expression and resistance to uropathogenic E. coli infection in kidney collecting duct cells via HIF-1α.,2020,10.1152/ajprenal.00228.2019,https://pubmed.ncbi.nlm.nih.gov/31841391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,32879664,Identification of an immune-related gene-based signature to predict prognosis of patients with gastric cancer.,2020,10.4251/wjgo.v12.i8.857,https://pubmed.ncbi.nlm.nih.gov/32879664/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,26832966,Lectin binding of human sperm associates with DEFB126 mutation and serves as a potential biomarker for subfertility.,2016,10.1038/srep20249,https://pubmed.ncbi.nlm.nih.gov/26832966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,21775668,A common mutation in the defensin DEFB126 causes impaired sperm function and subfertility.,2011,10.1126/scitranslmed.3002289,https://pubmed.ncbi.nlm.nih.gov/21775668/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,31533281,"Bacterial Virus Lambda Gpd-Fusions to Cathelicidins, α- and β-Defensins, and Disease-Specific Epitopes Evaluated for Antimicrobial Toxicity and Ability to Support Phage Display.",2019,10.3390/v11090869,https://pubmed.ncbi.nlm.nih.gov/31533281/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,23055202,Polymorphisms in pattern-recognition genes in the innate immunity system and risk of non-Hodgkin lymphoma.,2013,10.1002/em.21739,https://pubmed.ncbi.nlm.nih.gov/23055202/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,19423540,Common variation in genes related to innate immunity and risk of adult glioma.,2009,10.1158/1055-9965.epi-08-1041,https://pubmed.ncbi.nlm.nih.gov/19423540/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB126,ENSG00000125788,CTA,17928628,Alterations in gene expression in the caput epididymides of nonobstructive azoospermic men.,2008,10.1095/biolreprod.107.062760,https://pubmed.ncbi.nlm.nih.gov/17928628/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB134,ENSG00000205882,CTA,38473795,Analysis of the Association between Copy Number Variation and Ventricular Fibrillation in ST-Elevation Acute Myocardial Infarction.,2024,10.3390/ijms25052548,https://pubmed.ncbi.nlm.nih.gov/38473795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,42899482,Tumour Antigen-Specific Antibody Signatures as Diagnostic Biomarkers for Melanoma.,2026,10.1002/ijc.70726,https://pubmed.ncbi.nlm.nih.gov/42899482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,41913266,Testis-specific lncRNA Teshl regulates acrosome biogenesis to maintain sperm structure and function.,2026,10.1186/s13578-026-01563-6,https://pubmed.ncbi.nlm.nih.gov/41913266/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,41129177,Multiomic Selection of Cancer-Testis Antigens as Precision Immuno-oncologic Targets in Head and Neck Cancer.,2025,10.1001/jamaoto.2025.3563,https://pubmed.ncbi.nlm.nih.gov/41129177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,42171268,Genetic-Proteomic Integration Identifies Predictive Plasma Proteins for Multiple Sclerosis.,2026,10.1002/ana.78256,https://pubmed.ncbi.nlm.nih.gov/42171268/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,40599850,Design and immunogenic evaluation of multi-epitope vaccines for colorectal cancer: insights from molecular dynamics and &lt;i&gt;In-Vitro&lt;/i&gt; studies.,2025,10.3389/fonc.2025.1592072,https://pubmed.ncbi.nlm.nih.gov/40599850/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,38540029,Whole-Genome Identification and Characterization of the DKK Gene Family and Its Transcription Profiles: An Analysis of the Chinese Soft-Shell Turtle (Pelodiscus sinensis).,2024,10.3390/ani14060931,https://pubmed.ncbi.nlm.nih.gov/38540029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,40462010,Associations of plasma protein levels with risk of colorectal cancer: a proteome-wide Mendelian randomization study.,2025,10.1186/s12014-025-09545-5,https://pubmed.ncbi.nlm.nih.gov/40462010/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,38201279,"The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer.",2023,10.3390/cells13010075,https://pubmed.ncbi.nlm.nih.gov/38201279/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,37913874,Comparative genomic survey and functional analysis of DKKL1 during spermatogenesis in the Chinese soft-shelled turtle (Pelodiscus sinensis).,2024,10.1016/j.ijbiomac.2023.127696,https://pubmed.ncbi.nlm.nih.gov/37913874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,38473810,Transcriptomic Analysis Reveals Intrinsic Abnormalities in Endometrial Polyps.,2024,10.3390/ijms25052557,https://pubmed.ncbi.nlm.nih.gov/38473810/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,33281184,The Clinical Significance of Dickkopf Wnt Signaling Pathway Inhibitor Gene Family in Head and Neck Squamous Cell Carcinoma.,2020,10.12659/msm.927368,https://pubmed.ncbi.nlm.nih.gov/33281184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,35890029,Association of Intrauterine Microbes with Endometrial Factors in Intrauterine Adhesion Formation and after Medicine Treatment.,2022,10.3390/pathogens11070784,https://pubmed.ncbi.nlm.nih.gov/35890029/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,29643039,[Expression of DKKL1 in spermatozoa of men with asthenospermia].,2018,10.3969/j.issn.1673-4254.2018.03.13,https://pubmed.ncbi.nlm.nih.gov/29643039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,22817830,Developmental expression and function of DKKL1/Dkkl1 in humans and mice.,2012,10.1186/1477-7827-10-51,https://pubmed.ncbi.nlm.nih.gov/22817830/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,31605445,Hypothalamic transcriptome of tame and aggressive silver foxes (Vulpes vulpes) identifies gene expression differences shared across brain regions.,2020,10.1111/gbb.12614,https://pubmed.ncbi.nlm.nih.gov/31605445/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,27635108,Expression of Cancer Testis Antigens in Colorectal Cancer: New Prognostic and Therapeutic Implications.,2016,10.1155/2016/1987505,https://pubmed.ncbi.nlm.nih.gov/27635108/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,27826023,Allele-specific splicing effects on DKKL1 and ZNF419 transcripts in HeLa cells.,2017,10.1016/j.gene.2016.11.004,https://pubmed.ncbi.nlm.nih.gov/27826023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,19596310,The acrosomal protein Dickkopf-like 1 (DKKL1) is not essential for fertility.,2010,10.1016/j.fertnstert.2009.06.011,https://pubmed.ncbi.nlm.nih.gov/19596310/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,23295900,Region-specific expression of Dickkopf-like1 in the adult brain. Abbreviated title: Dkkl1 in the adult brain.,2013,10.1016/j.neulet.2012.12.040,https://pubmed.ncbi.nlm.nih.gov/23295900/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,21698294,"SLXL1, a novel acrosomal protein, interacts with DKKL1 and is involved in fertilization in mice.",2011,10.1371/journal.pone.0020866,https://pubmed.ncbi.nlm.nih.gov/21698294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,24190897,"Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes.",2014,10.1530/joe-13-0212,https://pubmed.ncbi.nlm.nih.gov/24190897/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DKKL1,ENSG00000104901,CTA,19176879,The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein.,2009,10.1095/biolreprod.108.075382,https://pubmed.ncbi.nlm.nih.gov/19176879/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,42905833,DMRT1 is required at two steps of ovarian differentiation in rabbits.,2026,10.1126/sciadv.aeh1087,https://pubmed.ncbi.nlm.nih.gov/42905833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,41851854,Multi-omic dissection of dmrt1-dependent regulatory networks reveals brain-blood-gonad crosstalk and ceRNA-mediated reprogramming during fertility restoration in Cynoglossus semilaevis.,2026,10.1186/s12864-026-12775-y,https://pubmed.ncbi.nlm.nih.gov/41851854/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,41977458,"Acidosis, Iron Dyshomeostasis and Inflammatory Injury.",2026,10.3390/ijms27073279,https://pubmed.ncbi.nlm.nih.gov/41977458/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,41481615,"Sex-specific functional evolution of Dmrt1 in African clawed frogs (Xenopus), and the importance of genetic tipping points in developmental biology.",2026,10.1371/journal.pgen.1011992,https://pubmed.ncbi.nlm.nih.gov/41481615/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,42704655,Trpv4 links environmental temperature to testicular differentiation in hermaphroditic ricefield eel.,2026,10.7554/elife.108272,https://pubmed.ncbi.nlm.nih.gov/42704655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,41123073,Sexual Dimorphic Expression of &lt;i&gt;Dmrt1&lt;/i&gt; in Adult Japanese Gecko (&lt;i&gt;Gekko japonicus&lt;/i&gt;).,2025,10.1159/000548987,https://pubmed.ncbi.nlm.nih.gov/41123073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,42184634,Establishment of an inducible knockout model for the chicken Z-chromosome-linked gene DMRT1.,2026,10.1016/j.psj.2026.107147,https://pubmed.ncbi.nlm.nih.gov/42184634/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,42883841,Comprehensive circRNA Profiling Reveals a Testis-Specific circRNA circdmrt1 as a Novel Regulator of Gonadal Development in Crucian Carp.,2026,10.3390/ijms27198593,https://pubmed.ncbi.nlm.nih.gov/42883841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,40121519,Decoding Dmrt1: insights into vertebrate sex determination and gonadal sex differentiation.,2025,10.1093/jeb/voaf031,https://pubmed.ncbi.nlm.nih.gov/40121519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,41850651,"Chick gonad explant electroporation reveals enhancers for testes determining factor, DMRT1.",2026,10.1016/j.ydbio.2026.03.011,https://pubmed.ncbi.nlm.nih.gov/41850651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,42450567,Curcumin Protects Mouse Spermatogonia from Triptolide-Induced Injury Through Modulation of Ferroptosis-Related Pathways.,2026,10.3390/biology15131019,https://pubmed.ncbi.nlm.nih.gov/42450567/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,42653294,Deciphering Production Potential and Gonadal Differentiation of the Backcross Hybrids Between &lt;i&gt;Argopecten irradians&lt;/i&gt; and &lt;i&gt;A. purpuratus&lt;/i&gt;.,2026,10.3390/ijms27167290,https://pubmed.ncbi.nlm.nih.gov/42653294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,41941753,Overlapping genetic etiology of pediatric and adult germ cell tumors.,2026,10.1093/jnci/djag097,https://pubmed.ncbi.nlm.nih.gov/41941753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,41594415,"Integrated Analysis of Testicular Histology, Sperm Quality, and Gene Expression (TGFB2, DMRT1) in Rooster Semen (Gallus gallus domesticus).",2026,10.3390/ani16020225,https://pubmed.ncbi.nlm.nih.gov/41594415/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,41910395,Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation.,2026,10.1111/febs.70522,https://pubmed.ncbi.nlm.nih.gov/41910395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,42677654,Lysosome DMT1-Mediated Renal Cell Ferroptosis Induced by Ochratoxin A.,2026,10.1021/acs.jafc.5c14984,https://pubmed.ncbi.nlm.nih.gov/42677654/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,42381562,Nano-Selenium Alleviates Heat Stress-Induced Testicular Injury in Roosters via Inhibiting Ferroptosis.,2026,10.1021/acs.jafc.6c06484,https://pubmed.ncbi.nlm.nih.gov/42381562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,42259495,DMT1 regulates systemic trace metal handling and developmental outcomes: Insights from targeted mutagenesis in zebrafish.,2026,10.1016/j.cbpc.2026.110597,https://pubmed.ncbi.nlm.nih.gov/42259495/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,41008613,"Gene Duplication, Translocation, and Molecular Evolution of &lt;i&gt;Dmrt1&lt;/i&gt; and Related Sex-Determining Genes in Anurans.",2025,10.3390/biom15091306,https://pubmed.ncbi.nlm.nih.gov/41008613/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,40169148,DMRT1 haploinsufficiency leads to secondary infertility in XY male rabbits†.,2025,10.1093/biolre/ioaf064,https://pubmed.ncbi.nlm.nih.gov/40169148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,42034968,Efficiency of bone marrow-derived cells in the treatment of experimental autoimmune type 1 diabetes: immunomodulatory and anti-apoptotic properties.,2026,10.1186/s12865-026-00823-x,https://pubmed.ncbi.nlm.nih.gov/42034968/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,42148083,Ferroptosis-immune crosstalk in CNS diseases: mechanisms and translational insights.,2026,10.3389/fimmu.2026.1807104,https://pubmed.ncbi.nlm.nih.gov/42148083/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,42884761,The Protective Effect of &lt;i&gt;Chlorella vulgaris&lt;/i&gt; Supplement Against Mercury Exposure Is Associated with DMT1: A Transcriptomic Analysis.,2026,10.3390/plants15192896,https://pubmed.ncbi.nlm.nih.gov/42884761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,42314264,Deciphering the complex mechanisms of action of lead detoxification by the green microalga Chlorella vulgaris.,2026,10.1016/j.phymed.2026.158349,https://pubmed.ncbi.nlm.nih.gov/42314264/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,42836163,"The Dual Role of Piezo1 in Cancer: Mechanotransduction, Microenvironment Remodelling, and Therapeutic Opportunities.",2026,10.2147/dddt.s640902,https://pubmed.ncbi.nlm.nih.gov/42836163/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,42347514,Effects of Chlorogenic Acid on Deoxynivalenol (DON)-Induced Ferroptosis in Porcine Alveolar Macrophages.,2026,10.3390/toxins18060260,https://pubmed.ncbi.nlm.nih.gov/42347514/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,42188925,Efficient and Safe Knockout of &lt;i&gt;AR&lt;/i&gt; and &lt;i&gt;DMRT1&lt;/i&gt; Mediated by Cytosine Base Editors in Chicken DF-1 and PGCs.,2026,10.3390/vetsci13050455,https://pubmed.ncbi.nlm.nih.gov/42188925/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,41483240,SLC38A1 Inhibits Ferroptosis of Alveolar Type II Epithelial Cells in Acute Lung Injury by Promoting Autophagic Degradation of Divalent Metal Transporter 1 (DMT1): an In Vivo and In Vitro Study.,2026,10.1007/s10753-025-02419-w,https://pubmed.ncbi.nlm.nih.gov/41483240/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,40991067,α-lipoic acid attenuates duodenal non-heme iron absorption via microRNA-mediated regulation of divalent metal transporter 1 in iron overloaded rats.,2025,10.1007/s11033-025-11034-9,https://pubmed.ncbi.nlm.nih.gov/40991067/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,41898692,Uric Acid Induces Hepatocytes Ferroptosis Through HIF-2α/DMT1-Mediated Iron Overload.,2026,10.3390/ijms27062833,https://pubmed.ncbi.nlm.nih.gov/41898692/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,42196531,Research Progress on the Mechanism of Ginsenosides in the Treatment of Parkinson's Disease.,2026,10.3390/ijms27104544,https://pubmed.ncbi.nlm.nih.gov/42196531/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,41990970,Mechanistic insights into hexavalent chromium-induced ferroptosis in mRTECs: a novel MTF1-IREB2-FTH1/DMT1 axis-mediated iron homeostasis dysregulation.,2026,10.1016/j.jare.2026.04.040,https://pubmed.ncbi.nlm.nih.gov/41990970/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,42903197,"Manganese dioxide nanozyme alleviates PEDV GIIc-associated growth retardation in neonatal piglets by improving antioxidant status, intestinal morphology, and manganese homeostasis.",2026,10.3389/fvets.2026.1963407,https://pubmed.ncbi.nlm.nih.gov/42903197/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,40945663,Ellagic acid's dual targeting of Dmt1 uptake and Nrf2 defense counters juvenile manganese neurotoxicity.,2025,10.1016/j.neuro.2025.103321,https://pubmed.ncbi.nlm.nih.gov/40945663/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,41518803,Molecular and histopathological mechanisms underlying pesticide-induced disruption of the hypothalamic-pituitary-gonadal axis in Japanese medaka.,2026,10.1016/j.jhazmat.2026.141069,https://pubmed.ncbi.nlm.nih.gov/41518803/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,23436708,Scanning of novel cancer/testis proteins by human testis proteomic analysis.,2013,10.1002/pmic.201200489,https://pubmed.ncbi.nlm.nih.gov/23436708/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRT1,ENSG00000137090,CTA,10857744,A new submicroscopic deletion that refines the 9p region for sex reversal.,2000,10.1006/geno.2000.6160,https://pubmed.ncbi.nlm.nih.gov/10857744/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTB1,ENSG00000143006,CTA,42733096,A Homozygous Variant in DMRTB1 Is Associated With Non-Obstructive Azoospermia in Humans.,2026,10.1111/cge.70243,https://pubmed.ncbi.nlm.nih.gov/42733096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTB1,ENSG00000143006,CTA,39903672,Deletion of an evolutionarily conserved TAD boundary impacts spermatogenesis in mice†.,2025,10.1093/biolre/ioaf017,https://pubmed.ncbi.nlm.nih.gov/39903672/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTB1,ENSG00000143006,CTA,40790730,Chromosome-level genome of Cyprinus rubrofuscus ♀ × Sinocyclocheilus grahami ♂ provides high-quality parental haplotype genomes and insights into hybrid economic traits enhancement.,2025,10.1186/s12864-025-11929-8,https://pubmed.ncbi.nlm.nih.gov/40790730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTB1,ENSG00000143006,CTA,36342669,dmrtb1 is involved in the testicular development in Larimichthys crocea.,2023,10.1530/rep-22-0214,https://pubmed.ncbi.nlm.nih.gov/36342669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTB1,ENSG00000143006,CTA,38203492,Analysis of Chromatin Accessibility and DNA Methylation to Reveal the Functions of Epigenetic Modifications in Cyprinus carpio Gonads.,2023,10.3390/ijms25010321,https://pubmed.ncbi.nlm.nih.gov/38203492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTB1,ENSG00000143006,CTA,34912379,"Identification and Characterization of Dimorphic Expression of Sex-Related Genes in Rock Bream, a Fish With Multiple Sex Chromosomes.",2021,10.3389/fgene.2021.791179,https://pubmed.ncbi.nlm.nih.gov/34912379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTB1,ENSG00000143006,CTA,30920770,Immunolocalization of DMRTB1 in human testis with normal and impaired spermatogenesis.,2019,10.1111/andr.12617,https://pubmed.ncbi.nlm.nih.gov/30920770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTB1,ENSG00000143006,CTA,34407824,Genes underlying the evolution of tetrapod testes size.,2021,10.1186/s12915-021-01107-z,https://pubmed.ncbi.nlm.nih.gov/34407824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTB1,ENSG00000143006,CTA,32164318,Loss of Cx43 in Murine Sertoli Cells Leads to Altered Prepubertal Sertoli Cell Maturation and Impairment of the Mitosis-Meiosis Switch.,2020,10.3390/cells9030676,https://pubmed.ncbi.nlm.nih.gov/32164318/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTB1,ENSG00000143006,CTA,33238277,Fertility Relevance Probability Analysis Shortlists Genetic Markers for Male Fertility Impairment.,2020,10.1159/000511117,https://pubmed.ncbi.nlm.nih.gov/33238277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTB1,ENSG00000143006,CTA,30241526,Proteogenomic characterization and comprehensive integrative genomic analysis of human colorectal cancer liver metastasis.,2018,10.1186/s12943-018-0890-1,https://pubmed.ncbi.nlm.nih.gov/30241526/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTB1,ENSG00000143006,CTA,25249458,The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis.,2014,10.1242/dev.113936,https://pubmed.ncbi.nlm.nih.gov/25249458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTB1,ENSG00000143006,CTA,33083119,Immune cell landscape analysis reveals prognostic immune cells and its potential mechanism in squamous cell lung carcinoma.,2020,10.7717/peerj.9996,https://pubmed.ncbi.nlm.nih.gov/33083119/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTB1,ENSG00000143006,CTA,27694960,Association of host genome with intestinal microbial composition in a large healthy cohort.,2016,10.1038/ng.3693,https://pubmed.ncbi.nlm.nih.gov/27694960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTB1,ENSG00000143006,CTA,25082981,Involvement of doublesex and mab-3-related transcription factors in human female germ cell development demonstrated by xenograft and interference RNA strategies.,2014,10.1093/molehr/gau058,https://pubmed.ncbi.nlm.nih.gov/25082981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTB1,ENSG00000143006,CTA,11863363,Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination.,2002,10.1006/geno.2002.6711,https://pubmed.ncbi.nlm.nih.gov/11863363/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,41609899,Stress-specific expression of HSPA and DNAJ chaperones regulated by NRF2/HSF1 in neurodegenerative conditions.,2026,10.1007/s11010-026-05484-3,https://pubmed.ncbi.nlm.nih.gov/41609899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,38936156,The heat shock protein DNAJB8 inhibits pseudorabies virus replication by autophagy.,2024,10.1016/j.vetmic.2024.110165,https://pubmed.ncbi.nlm.nih.gov/38936156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,38508190,DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity.,2024,10.1016/j.str.2024.02.015,https://pubmed.ncbi.nlm.nih.gov/38508190/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,36526673,Development of CAR-T cells specifically targeting cancer stem cell antigen DNAJB8 against solid tumours.,2023,10.1038/s41416-022-02100-1,https://pubmed.ncbi.nlm.nih.gov/36526673/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,38850318,Factors affecting protein recovery during Hsp40 affinity profiling.,2024,10.1007/s00216-024-05362-1,https://pubmed.ncbi.nlm.nih.gov/38850318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,33391882,"Dnajb8, a target gene of SOX30, is dispensable for male fertility in mice.",2020,10.7717/peerj.10582,https://pubmed.ncbi.nlm.nih.gov/33391882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,36723955,DNAJB8 facilitates autophagic-lysosomal degradation of viral Vif protein and restricts HIV-1 virion infectivity by rescuing APOBEC3G expression in host cells.,2023,10.1096/fj.202201738r,https://pubmed.ncbi.nlm.nih.gov/36723955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,35165262,DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer.,2022,10.1038/s41419-022-04599-x,https://pubmed.ncbi.nlm.nih.gov/35165262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,36581212,Extracellular chaperone networks and the export of J-domain proteins.,2023,10.1016/j.jbc.2022.102840,https://pubmed.ncbi.nlm.nih.gov/36581212/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,32753678,Development of an artificial antibody specific for HLA/peptide complex derived from cancer stem-like cell/cancer-initiating cell antigen DNAJB8.,2020,10.1038/s41416-020-1017-1,https://pubmed.ncbi.nlm.nih.gov/32753678/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,36675675,Genetic Predictors of the Development of Complications after Coronary Stenting.,2022,10.3390/jpm13010014,https://pubmed.ncbi.nlm.nih.gov/36675675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,33674449,DNAJB chaperones suppress destabilised protein aggregation via a region distinct from that used to inhibit amyloidogenesis.,2021,10.1242/jcs.255596,https://pubmed.ncbi.nlm.nih.gov/33674449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,33574241,Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone.,2021,10.1038/s41467-021-21147-x,https://pubmed.ncbi.nlm.nih.gov/33574241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,34874156,Hsp40 Affinity to Identify Proteins Destabilized by Cellular Toxicant Exposure.,2021,10.1021/acs.analchem.1c04230,https://pubmed.ncbi.nlm.nih.gov/34874156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,24450541,Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells.,2014,10.1111/cas.12362,https://pubmed.ncbi.nlm.nih.gov/24450541/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,29316077,Cellular stress induces cancer stem-like cells through expression of DNAJB8 by activation of heat shock factor 1.,2018,10.1111/cas.13501,https://pubmed.ncbi.nlm.nih.gov/29316077/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,26751205,"Dnajb8, a Member of the Heat Shock Protein 40 Family Has a Role in the Tumor Initiation and Resistance to Docetaxel but Is Dispensable for Stress Response.",2016,10.1371/journal.pone.0146501,https://pubmed.ncbi.nlm.nih.gov/26751205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,37427419,Cellular Exposure to Chloroacetanilide Herbicides Induces Distinct Protein Destabilization Profiles.,2023,10.1021/acschembio.3c00338,https://pubmed.ncbi.nlm.nih.gov/37427419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,27713507,Versatile members of the DNAJ family show Hsp70 dependent anti-aggregation activity on RING1 mutant parkin C289G.,2016,10.1038/srep34830,https://pubmed.ncbi.nlm.nih.gov/27713507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,23574628,"Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene.",2013,10.1111/tan.12113,https://pubmed.ncbi.nlm.nih.gov/23574628/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,29107688,"Identification of antigenic peptides from novel renal cancer stem-like cell antigen, DNAJB8.",2017,10.1016/j.bbrc.2017.10.146,https://pubmed.ncbi.nlm.nih.gov/29107688/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,22552285,HSP DNAJB8 controls tumor-initiating ability in renal cancer stem-like cells.,2012,10.1158/0008-5472.can-11-3062,https://pubmed.ncbi.nlm.nih.gov/22552285/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,23612975,The DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptides.,2013,10.1074/jbc.m112.421685,https://pubmed.ncbi.nlm.nih.gov/23612975/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,20159555,A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation.,2010,10.1016/j.molcel.2010.01.001,https://pubmed.ncbi.nlm.nih.gov/20159555/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,25506890,Cancer/testis antigens trigger epithelial-mesenchymal transition and genesis of cancer stem-like cells.,2015,10.2174/1381612821666141211154707,https://pubmed.ncbi.nlm.nih.gov/25506890/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,23904097,DNAJB6 is a peptide-binding chaperone which can suppress amyloid fibrillation of polyglutamine peptides at substoichiometric molar ratios.,2014,10.1007/s12192-013-0448-5,https://pubmed.ncbi.nlm.nih.gov/23904097/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB8,ENSG00000179407,CTA,20556630,Co-chaperones are limiting in a depleted chaperone network.,2010,10.1007/s00018-010-0430-7,https://pubmed.ncbi.nlm.nih.gov/20556630/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC5G,ENSG00000163793,CTA,41351017,A cross-tissue transcriptome-wide association study identifies novel candidate genes associated with brain glymphatic system function.,2025,10.1186/s13041-025-01258-y,https://pubmed.ncbi.nlm.nih.gov/41351017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC5G,ENSG00000163793,CTA,42902308,GlycA-gene interactions in cardiovascular-kidney-metabolic syndrome: evidence from genetic association.,2026,10.1186/s13098-026-02252-7,https://pubmed.ncbi.nlm.nih.gov/42902308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC5G,ENSG00000163793,CTA,32415241,"Identification of novel methylation markers in HPV-associated oropharyngeal cancer: genome-wide discovery, tissue verification and validation testing in ctDNA.",2020,10.1038/s41388-020-1327-z,https://pubmed.ncbi.nlm.nih.gov/32415241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC5G,ENSG00000163793,CTA,36723955,DNAJB8 facilitates autophagic-lysosomal degradation of viral Vif protein and restricts HIV-1 virion infectivity by rescuing APOBEC3G expression in host cells.,2023,10.1096/fj.202201738r,https://pubmed.ncbi.nlm.nih.gov/36723955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC5G,ENSG00000163793,CTA,21984199,Protection against protein aggregation by alpha-crystallin as a mechanism of preconditioning.,2012,10.1007/s11064-011-0601-4,https://pubmed.ncbi.nlm.nih.gov/21984199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUSP21,ENSG00000189037,CTA,41865468,Dual-specificity phosphatase 21 enhances the sensitivity of imatinib-resistant chronic myeloid leukemia cells to ponatinib through GATA-1-mediated erythroid differentiation.,2026,10.1016/j.bbrc.2026.153646,https://pubmed.ncbi.nlm.nih.gov/41865468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUSP21,ENSG00000189037,CTA,41764189,Doublet microtubule-associated tektins and enzymes differentially regulate sperm flagellar integrity and motility.,2026,10.1038/s41467-026-69714-4,https://pubmed.ncbi.nlm.nih.gov/41764189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUSP21,ENSG00000189037,CTA,40966956,DUSP21 expression is associated with obstructive sleep apnea in pediatric patients with obesity.,2025,10.1016/j.sleep.2025.106809,https://pubmed.ncbi.nlm.nih.gov/40966956/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUSP21,ENSG00000189037,CTA,37476896,Expression of dual-specificity phosphatases in TGFß1-induced EMT in SKOV3 cells.,2023,10.55730/1300-0144.5626,https://pubmed.ncbi.nlm.nih.gov/37476896/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUSP21,ENSG00000189037,CTA,32211113,A fetus with Kabuki syndrome 2 detected by chromosomal microarray analysis.,2020,,https://pubmed.ncbi.nlm.nih.gov/32211113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUSP21,ENSG00000189037,CTA,23929653,RNA interference against cancer/testis genes identifies dual specificity phosphatase 21 as a potential therapeutic target in human hepatocellular carcinoma.,2014,10.1002/hep.26665,https://pubmed.ncbi.nlm.nih.gov/23929653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUSP21,ENSG00000189037,CTA,27609023,A 19-Gene expression signature as a predictor of survival in colorectal cancer.,2016,10.1186/s12920-016-0218-1,https://pubmed.ncbi.nlm.nih.gov/27609023/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUSP21,ENSG00000189037,CTA,12408986,Identification and characterization of two novel low-molecular-weight dual specificity phosphatases.,2002,10.1016/s0006-291x(02)02488-9,https://pubmed.ncbi.nlm.nih.gov/12408986/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDDM3B,ENSG00000181552,CTA,40224648,Sex differences in proteomics of cardiovascular disease - &lt;i&gt;Results from the Yale-CMD registry&lt;/i&gt;.,2025,10.1016/j.ijcha.2025.101667,https://pubmed.ncbi.nlm.nih.gov/40224648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDDM3B,ENSG00000181552,CTA,36959545,Discovery of novel glioma serum biomarkers by proximity extension assay.,2023,10.1186/s12014-023-09400-5,https://pubmed.ncbi.nlm.nih.gov/36959545/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDDM3B,ENSG00000181552,CTA,35137089,Sperm acquire epididymis-derived proteins through epididymosomes.,2022,10.1093/humrep/deac015,https://pubmed.ncbi.nlm.nih.gov/35137089/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDDM3B,ENSG00000181552,CTA,37082114,Non-coding regions of nuclear-DNA-encoded mitochondrial genes and intergenic sequences are targeted by autoantibodies in breast cancer.,2022,10.3389/fgene.2022.970619,https://pubmed.ncbi.nlm.nih.gov/37082114/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDDM3B,ENSG00000181552,CTA,32256100,Pharmacogenetics of Pediatric Asthma: Current Perspectives.,2020,10.2147/pgpm.s201276,https://pubmed.ncbi.nlm.nih.gov/32256100/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDDM3B,ENSG00000181552,CTA,26662397,Copy number variations in spermatogenic failure patients with chromosomal abnormalities and unexplained azoospermia.,2015,10.4238/2015.december.7.17,https://pubmed.ncbi.nlm.nih.gov/26662397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDDM3B,ENSG00000181552,CTA,17928628,Alterations in gene expression in the caput epididymides of nonobstructive azoospermic men.,2008,10.1095/biolreprod.107.062760,https://pubmed.ncbi.nlm.nih.gov/17928628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDDM3B,ENSG00000181552,CTA,2983668,A 17 beta-hydroxysteroid dehydrogenase of female rabbit liver cytosol. Purification and characterization of multiple forms of the enzyme.,1985,10.1042/bj2250383,https://pubmed.ncbi.nlm.nih.gov/2983668/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDDM3B,ENSG00000181552,CTA,32791477,Valorizing lignin-like dyes and textile dyeing wastewater by a newly constructed lipid-producing and lignin modifying oleaginous yeast consortium valued for biodiesel and bioremediation.,2021,10.1016/j.jhazmat.2020.123575,https://pubmed.ncbi.nlm.nih.gov/32791477/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDDM3B,ENSG00000181552,CTA,21144656,"Textile dye degradation by bacterial consortium and subsequent toxicological analysis of dye and dye metabolites using cytotoxicity, genotoxicity and oxidative stress studies.",2011,10.1016/j.jhazmat.2010.11.049,https://pubmed.ncbi.nlm.nih.gov/21144656/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDDM3B,ENSG00000181552,CTA,19322828,Biodegradation of hazardous triphenylmethane dye methyl violet by Rhizobium radiobacter (MTCC 8161).,2009,10.1002/jobm.200800200,https://pubmed.ncbi.nlm.nih.gov/19322828/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB9,ENSG00000214360,CTA,41271765,ARMH2 is a cytosolic component of CatSper crucial for sperm function.,2025,10.1038/s41467-025-65952-0,https://pubmed.ncbi.nlm.nih.gov/41271765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB9,ENSG00000214360,CTA,34919125,C2CD6 regulates targeting and organization of the CatSper calcium channel complex in sperm flagella.,2022,10.1242/dev.199988,https://pubmed.ncbi.nlm.nih.gov/34919125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB9,ENSG00000214360,CTA,31056283,Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility.,2019,10.1016/j.cell.2019.03.047,https://pubmed.ncbi.nlm.nih.gov/31056283/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB9,ENSG00000214360,CTA,35715406,3D structure and in situ arrangements of CatSper channel in the sperm flagellum.,2022,10.1038/s41467-022-31050-8,https://pubmed.ncbi.nlm.nih.gov/35715406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB9,ENSG00000214360,CTA,35438819,CatSper and its CaM-like Ca2+ sensor EFCAB9 are necessary for the path chirality of sperm.,2022,10.1096/fj.202101656rr,https://pubmed.ncbi.nlm.nih.gov/35438819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB9,ENSG00000214360,CTA,33946695,Molecular Evolution of CatSper in Mammals and Function of Sperm Hyperactivation in Gray Short-Tailed Opossum.,2021,10.3390/cells10051047,https://pubmed.ncbi.nlm.nih.gov/33946695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,41980251,Effectiveness of a group nursing intervention in reducing anxiety and depression for smoking cessation: a quasi-experimental study in light of Afaf Meleis' Transition Theory.,2026,10.17533/udea.iee.v44n1e10,https://pubmed.ncbi.nlm.nih.gov/41980251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,42254241,The influence of unhealthy lifestyle on semen quality: results from a cross-sectional study and Mendelian randomization analysis.,2026,10.1097/ms9.0000000000004982,https://pubmed.ncbi.nlm.nih.gov/42254241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,42307351,Specific situation theory of the transition experience lived by people with intestinal ostomies and their families.,2026,10.1590/1518-8345.7979.4858,https://pubmed.ncbi.nlm.nih.gov/42307351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,42610172,Critique of the Peaceful End-of-Life Theory Using Meleis' 2012 Approach.,2026,10.4103/ijnmr.ijnmr_68_24,https://pubmed.ncbi.nlm.nih.gov/42610172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,39648428,Exploring the Biological Effects of Polystyrene Nanoplastics on Spermatogenesis: Insights From Transcriptomic Analysis in Mouse Spermatocytes.,2025,10.1177/10915818241305086,https://pubmed.ncbi.nlm.nih.gov/39648428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,40263929,Identification of Anoikis-Related Genes in Gastric Cancer: Bioinformatics and Experimental Validation.,2025,10.1002/cam4.70907,https://pubmed.ncbi.nlm.nih.gov/40263929/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,40933246,Educational-Care Needs for Hospital-Home Transition of Children With Hematological Cancer.,2025,10.1155/nrp/4551422,https://pubmed.ncbi.nlm.nih.gov/40933246/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,36050562,The vertebrate- and testis- specific transmembrane protein C11ORF94 plays a critical role in sperm-oocyte membrane binding.,2022,10.1186/s43556-022-00092-1,https://pubmed.ncbi.nlm.nih.gov/36050562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,37782577,"Bull Sperm SWATH-MS-Based Proteomics Reveals Link between High Fertility and Energy Production, Motility Structures, and Sperm-Oocyte Interaction.",2023,10.1021/acs.jproteome.3c00461,https://pubmed.ncbi.nlm.nih.gov/37782577/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,35794675,Establishment of a male fertility prediction model with sperm RNA markers in pigs as a translational animal model.,2022,10.1186/s40104-022-00729-9,https://pubmed.ncbi.nlm.nih.gov/35794675/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,39197355,Barriers to healthy transitions between nursing homes and emergency departments.,2024,10.1016/j.gerinurse.2024.08.034,https://pubmed.ncbi.nlm.nih.gov/39197355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,36456645,Development and validation of a novel immune-related prognostic signature in lung squamous cell carcinoma patients.,2022,10.1038/s41598-022-23140-w,https://pubmed.ncbi.nlm.nih.gov/36456645/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,37988335,Allelic variations of WAK106-E2Fa-DPb1-UGT74E2 module regulate fibre properties in Populus tomentosa.,2024,10.1111/pbi.14239,https://pubmed.ncbi.nlm.nih.gov/37988335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,37079096,Cryostress induces fragmentation and alters the abundance of sperm transcripts associated with fertilizing competence and reproductive processes in buffalo.,2023,10.1007/s00441-023-03764-8,https://pubmed.ncbi.nlm.nih.gov/37079096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,32665575,Optimization of sperm RNA processing for developmental research.,2020,10.1038/s41598-020-68486-1,https://pubmed.ncbi.nlm.nih.gov/32665575/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,37283433,Transitions experienced by mothers of children/adolescents with sickle cell disease in the context of the COVID-19 pandemic.,2023,10.1590/1983-1447.2023.20220075.en,https://pubmed.ncbi.nlm.nih.gov/37283433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,35968119,Transcriptome and association mapping revealed functional genes respond to drought stress in Populus.,2022,10.3389/fpls.2022.829888,https://pubmed.ncbi.nlm.nih.gov/35968119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,40529940,Analysis of the concept of caregiver role strain in informal caregivers: an approach according to Meleis.,2025,10.15649/cuidarte.4000,https://pubmed.ncbi.nlm.nih.gov/40529940/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,36172516,The role of microbiota in autism spectrum disorder: A bibliometric analysis based on original articles.,2022,10.3389/fpsyt.2022.976827,https://pubmed.ncbi.nlm.nih.gov/36172516/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,30328350,Deletion of Eqtn in mice reduces male fertility and sperm-egg adhesion.,2018,10.1530/rep-18-0394,https://pubmed.ncbi.nlm.nih.gov/30328350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,29764106,The Challenges of a Complex and Innovative Telehealth Project: A Qualitative Evaluation of the Eastern Quebec Telepathology Network.,2018,10.15171/ijhpm.2017.106,https://pubmed.ncbi.nlm.nih.gov/29764106/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EQTN,ENSG00000120160,CTA,11118625,"Isolation and characterisation of a novel human gene (C9orf11) on chromosome 9p21, a region frequently deleted in human cancer.",2000,10.1016/s0167-4781(00)00272-4,https://pubmed.ncbi.nlm.nih.gov/11118625/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
ERVV-1,ENSG00000269526,CTA,38408442,Human Endogenous Retroviruses in Breast Cancer: Altered Expression Pattern Implicates Divergent Roles in Carcinogenesis.,2024,10.1159/000538021,https://pubmed.ncbi.nlm.nih.gov/38408442/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVV-1,ENSG00000269526,CTA,34410386,The Oldest Co-opted gag Gene of a Human Endogenous Retrovirus Shows Placenta-Specific Expression and Is Upregulated in Diffuse Large B-Cell Lymphomas.,2021,10.1093/molbev/msab245,https://pubmed.ncbi.nlm.nih.gov/34410386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVV-1,ENSG00000269526,CTA,33504453,Syncytins expressed in human placental trophoblast.,2021,10.1016/j.placenta.2021.01.006,https://pubmed.ncbi.nlm.nih.gov/33504453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVV-1,ENSG00000269526,CTA,18826608,Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.,2008,10.1186/1471-2148-8-266,https://pubmed.ncbi.nlm.nih.gov/18826608/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVV-2,ENSG00000268964,CTA,38604984,Characterization of the endogenous retrovirus-derived placenta-specific soluble protein EnvV-Fca from domestic cats.,2024,10.1002/1873-3468.14873,https://pubmed.ncbi.nlm.nih.gov/38604984/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVV-2,ENSG00000268964,CTA,31194719,Identification of a 5-Gene Signature Predicting Progression and Prognosis of Clear Cell Renal Cell Carcinoma.,2019,10.12659/msm.917399,https://pubmed.ncbi.nlm.nih.gov/31194719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVV-2,ENSG00000268964,CTA,33504453,Syncytins expressed in human placental trophoblast.,2021,10.1016/j.placenta.2021.01.006,https://pubmed.ncbi.nlm.nih.gov/33504453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVV-2,ENSG00000268964,CTA,23085571,Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets.,2012,10.18632/oncotarget.679,https://pubmed.ncbi.nlm.nih.gov/23085571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVV-2,ENSG00000268964,CTA,18826608,Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.,2008,10.1186/1471-2148-8-266,https://pubmed.ncbi.nlm.nih.gov/18826608/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVV-2,ENSG00000268964,CTA,26266541,Differential Effects of Sodium Butyrate and Lithium Chloride on Rhesus Monkey Trophoblast Differentiation.,2015,10.1371/journal.pone.0135089,https://pubmed.ncbi.nlm.nih.gov/26266541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,37783880,ESX1 gene as a potential candidate responsible for male infertility in nonobstructive azoospermia.,2023,10.1038/s41598-023-43854-9,https://pubmed.ncbi.nlm.nih.gov/37783880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,33633269,Association of ESX1 gene variants with non-obstructive azoospermia in Chinese males.,2021,10.1038/s41598-021-84182-0,https://pubmed.ncbi.nlm.nih.gov/33633269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,36769182,&lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt; Evasion of Guanylate Binding Protein-Mediated Host Defense in Mice Requires the ESX1 Secretion System.,2023,10.3390/ijms24032861,https://pubmed.ncbi.nlm.nih.gov/36769182/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,37076787,Seminal plasma biomarkers for predicting successful sperm retrieval in patients with nonobstructive azoospermia: a narrative review of human studies.,2023,10.1186/s12610-023-00184-0,https://pubmed.ncbi.nlm.nih.gov/37076787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,36017582,Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia.,2022,10.1111/andr.13269,https://pubmed.ncbi.nlm.nih.gov/36017582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,35297678,A Polymorphic Gene within the Mycobacterium smegmatis esx1 Locus Determines Mycobacterial Self-Identity and Conjugal Compatibility.,2022,10.1128/mbio.00213-22,https://pubmed.ncbi.nlm.nih.gov/35297678/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,31793700,"Could analysis of testis-specific genes, as biomarkers in seminal plasma, predict presence of focal spermatogenesis in non-obstructive azoospermia?",2020,10.1111/and.13483,https://pubmed.ncbi.nlm.nih.gov/31793700/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,30054974,"Among seven testis-specific molecular markers, SPEM1 appears to have a significant clinical value for prediction of sperm retrieval in azoospermic men.",2018,10.1111/andr.12528,https://pubmed.ncbi.nlm.nih.gov/30054974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,29440900,"Gestational exposure to titanium dioxide nanoparticles impairs the placentation through dysregulation of vascularization, proliferation and apoptosis in mice.",2018,10.2147/ijn.s152400,https://pubmed.ncbi.nlm.nih.gov/29440900/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,25316452,ESX1 mRNA expression in seminal fluid is an indicator of residual spermatogenesis in non-obstructive azoospermic men.,2014,10.1093/humrep/deu261,https://pubmed.ncbi.nlm.nih.gov/25316452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,34420788,ESX-5-targeted export of ESAT-6 in BCG combines enhanced immunogenicity & efficacy against murine tuberculosis with low virulence and reduced persistence.,2021,10.1016/j.vaccine.2021.08.030,https://pubmed.ncbi.nlm.nih.gov/34420788/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,34156290,"Surface-Shaving Proteomics of Mycobacterium marinum Identifies Biofilm Subtype-Specific Changes Affecting Virulence, Tolerance, and Persistence.",2021,10.1128/msystems.00500-21,https://pubmed.ncbi.nlm.nih.gov/34156290/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,31822682,Genomic Landscape of Intramedullary Spinal Cord Gliomas.,2019,10.1038/s41598-019-54286-9,https://pubmed.ncbi.nlm.nih.gov/31822682/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,37337145,X-linked genes influence various complex traits in dairy cattle.,2023,10.1186/s12864-023-09438-7,https://pubmed.ncbi.nlm.nih.gov/37337145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,34289236,Maternal Exposure to Oxidized Soybean Oil Impairs Placental Development by Modulating Nutrient Transporters in a Rat Model.,2021,10.1002/mnfr.202100301,https://pubmed.ncbi.nlm.nih.gov/34289236/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,20356899,ESX1 gene expression as a robust marker of residual spermatogenesis in azoospermic men.,2010,10.1093/humrep/deq074,https://pubmed.ncbi.nlm.nih.gov/20356899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,16226127,Identification of two novel allelic variants of ESX1L in the human placenta: lack of an association with intrauterine growth restriction.,2005,10.1016/j.placenta.2004.10.004,https://pubmed.ncbi.nlm.nih.gov/16226127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,30815463,Expression of Glutamate Receptor Subtype 3 Is Epigenetically Regulated in Podocytes under Diabetic Conditions.,2019,10.1159/000492933,https://pubmed.ncbi.nlm.nih.gov/30815463/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,24631198,ESX1-dependent fractalkine mediates chemotaxis and Mycobacterium tuberculosis infection in humans.,2014,10.1016/j.tube.2014.01.004,https://pubmed.ncbi.nlm.nih.gov/24631198/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,33564309,Identification and Analysis of Three Hub Prognostic Genes Related to Osteosarcoma Metastasis.,2021,10.1155/2021/6646459,https://pubmed.ncbi.nlm.nih.gov/33564309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,20585630,EspA acts as a critical mediator of ESX1-dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity.,2010,10.1371/journal.ppat.1000957,https://pubmed.ncbi.nlm.nih.gov/20585630/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,30594716,Gestational exposure to acrylamide inhibits mouse placental development in vivo.,2019,10.1016/j.jhazmat.2018.12.061,https://pubmed.ncbi.nlm.nih.gov/30594716/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,32266172,Comparative Genomic and Transcriptomic Analyses of Mycobacterium kansasii Subtypes Provide New Insights Into Their Pathogenicity and Taxonomy.,2020,10.3389/fcimb.2020.00122,https://pubmed.ncbi.nlm.nih.gov/32266172/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,25935407,Maternal exposure to di-(2-ethylhexyl) phthalate disrupts placental growth and development in pregnant mice.,2015,10.1016/j.jhazmat.2015.04.065,https://pubmed.ncbi.nlm.nih.gov/25935407/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,28854272,Overall survival in EGFR mutated non-small-cell lung cancer patients treated with afatinib after EGFR TKI and resistant mechanisms upon disease progression.,2017,10.1371/journal.pone.0182885,https://pubmed.ncbi.nlm.nih.gov/28854272/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,22233444,Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria.,2012,10.1111/j.1365-2958.2011.07958.x,https://pubmed.ncbi.nlm.nih.gov/22233444/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,24874799,The PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis.,2014,10.1371/journal.ppat.1004183,https://pubmed.ncbi.nlm.nih.gov/24874799/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,20430877,The Rhox genes.,2010,10.1530/rep-10-0100,https://pubmed.ncbi.nlm.nih.gov/20430877/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,25505644,Distributive Conjugal Transfer: New Insights into Horizontal Gene Transfer and Genetic Exchange in Mycobacteria.,2014,10.1128/microbiolspec.mgm2-0022-2013,https://pubmed.ncbi.nlm.nih.gov/25505644/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,21483832,Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages.,2011,10.1371/journal.pone.0018367,https://pubmed.ncbi.nlm.nih.gov/21483832/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,15235584,Paired-like homeodomain protein ESXR1 possesses a cleavable C-terminal region that inhibits cyclin degradation.,2004,10.1038/sj.onc.1207884,https://pubmed.ncbi.nlm.nih.gov/15235584/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESX1,ENSG00000123576,CTA,11374906,"ESX1L, a novel X chromosome-linked human homeobox gene expressed in the placenta and testis.",2001,10.1006/geno.2001.6532,https://pubmed.ncbi.nlm.nih.gov/11374906/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXD1,ENSG00000178997,CTA,42631111,Pathogenic Variants in PET Complex Encoding Genes &lt;i&gt;TDRD12&lt;/i&gt; and &lt;i&gt;EXD1&lt;/i&gt; Impair piRNA Biogenesis and Cause Male Infertility.,2026,10.1155/humu/7629729,https://pubmed.ncbi.nlm.nih.gov/42631111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXD1,ENSG00000178997,CTA,40645105,Novel homozygous variants in piRNA pathway factors lead to male infertility in humans.,2025,10.1016/j.rbmo.2025.104974,https://pubmed.ncbi.nlm.nih.gov/40645105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXD1,ENSG00000178997,CTA,36624638,Intermitochondrial cement (IMC) harbors piRNA biogenesis machinery and exonuclease domain-containing proteins EXD1 and EXD2 in mouse spermatocytes.,2023,10.1111/andr.13361,https://pubmed.ncbi.nlm.nih.gov/36624638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXD1,ENSG00000178997,CTA,36693612,"AtSIEK, an EXD1-like protein with KH domain, involves in salt stress response by interacting with FRY2/CPL1.",2023,10.1016/j.ijbiomac.2023.123369,https://pubmed.ncbi.nlm.nih.gov/36693612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXD1,ENSG00000178997,CTA,32182846,Homoarginine- and Creatine-Dependent Gene Regulation in Murine Brains with l-Arginine:Glycine Amidinotransferase Deficiency.,2020,10.3390/ijms21051865,https://pubmed.ncbi.nlm.nih.gov/32182846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXD1,ENSG00000178997,CTA,26669262,PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway.,2016,10.1016/j.molcel.2015.11.009,https://pubmed.ncbi.nlm.nih.gov/26669262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,42238311,CXorf67 in malignancies: Deciphering epigenetic landscapes and clinical implications for precision oncology.,2026,10.1016/j.gendis.2025.101933,https://pubmed.ncbi.nlm.nih.gov/42238311/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,41596609,EZHIP in Pediatric Brain Tumors: From Epigenetic Mimicry to Therapeutic Vulnerabilities.,2026,10.3390/ijms27020963,https://pubmed.ncbi.nlm.nih.gov/41596609/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,42453183,EZHIP and H3K27me3 are useful diagnostic markers for germinoma and for the germinoma component of germ cell tumors of central nervous system.,2026,10.1093/nop/npag027,https://pubmed.ncbi.nlm.nih.gov/42453183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,41204377,EZHIP boosts neuronal-like synaptic gene programs and depresses polyamine metabolism.,2025,10.1186/s40478-025-02141-6,https://pubmed.ncbi.nlm.nih.gov/41204377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,42120298,&lt;i&gt;In Silico&lt;/i&gt; Prediction of EZHIP Post-Translational Modification Sites and Small-Molecule High-Throughput Screening for Quantitative EZHIP Modulation.,2026,10.14791/btrt.2025.0047,https://pubmed.ncbi.nlm.nih.gov/42120298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,40695784,Aberrant EZHIP expression drives tumorigenesis in osteosarcoma.,2025,10.1038/s41467-025-61558-8,https://pubmed.ncbi.nlm.nih.gov/40695784/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,39874681,Oncohistone-sculpted epigenetic mechanisms in pediatric brain cancer.,2025,10.1016/j.coph.2025.102505,https://pubmed.ncbi.nlm.nih.gov/39874681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,42773286,"Posterior fossa ependymoma: a comprehensive review of molecular classification, management guidelines, and clinical outcomes (Part I of ependymomas across compartments).",2026,10.1007/s11060-026-05808-9,https://pubmed.ncbi.nlm.nih.gov/42773286/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,40971955,Novel modifiers of oncoprotein-mediated Polycomb inhibition in Drosophila melanogaster.,2025,10.1093/genetics/iyaf193,https://pubmed.ncbi.nlm.nih.gov/40971955/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,41535302,H3K27me3-dependent imprinting and transcriptional regulation in early mouse embryos requires EZHIP-mediated restriction of PRC2 activity.,2026,10.1038/s41467-026-68467-4,https://pubmed.ncbi.nlm.nih.gov/41535302/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,41329819,Total Synthesis and Anticancer Study of (+)-Verticillin A.,2025,10.1021/jacs.5c16112,https://pubmed.ncbi.nlm.nih.gov/41329819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,39343635,EZHIP's role in diffuse midline glioma: echoes of oncohistones?,2024,10.1016/j.trecan.2024.09.002,https://pubmed.ncbi.nlm.nih.gov/39343635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,40887057,cIMPACT-NOW update 11: Proposal on adaptation of diagnostic criteria for IDH- and H3-wildtype diffuse high-grade gliomas and for posterior fossa ependymal tumors.,2026,10.1111/bpa.70035,https://pubmed.ncbi.nlm.nih.gov/40887057/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,41454766,"The contribution of methylation profiling in neuropathological diagnosis of central nervous system tumors in children, adolescent and young adults.",2025,10.32074/1591-951x-1226,https://pubmed.ncbi.nlm.nih.gov/41454766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,41954087,Role of Surrogate Immunohistochemistry Markers in CNS Tumors in the Era of Molecular Diagnostics With Recent Updates.,2026,10.1097/pap.0000000000000533,https://pubmed.ncbi.nlm.nih.gov/41954087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,37341056,Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer.,2023,10.1002/1878-0261.13474,https://pubmed.ncbi.nlm.nih.gov/37341056/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,41352627,Diagnostic Utility and Clinicopathologic Associations of Histone H3 Lysine 27 Trimethylation (H3K27me3) Immunohistochemistry for Merkel Cell Carcinoma.,2026,10.1016/j.modpat.2025.100945,https://pubmed.ncbi.nlm.nih.gov/41352627/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,40849656,H3F3B p.K27I-mutant diffuse midline glioma is a distinct subtype of H3K27-altered diffuse midline glioma.,2025,10.1186/s40478-025-02101-0,https://pubmed.ncbi.nlm.nih.gov/40849656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,33420598,Correction to: EZH2 inhibitory protein (EZHIP/Cxorf67) expression correlates strongly with H3K27me3 loss in posterior fossa ependymomas and is mutually exclusive with H3K27M mutations.,2021,10.1007/s10014-020-00393-9,https://pubmed.ncbi.nlm.nih.gov/33420598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,38479992,Synergistic effect of poly (ADP-ribose) polymerase (PARP) inhibitor with chemotherapy on CXorf67-elevated posterior fossa group A ependymoma.,2024,10.1097/cm9.0000000000003040,https://pubmed.ncbi.nlm.nih.gov/38479992/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,34613815,Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas.,2021,10.1126/scitranslmed.abc0497,https://pubmed.ncbi.nlm.nih.gov/34613815/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,36882456,Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes.,2023,10.1038/s41598-023-30395-4,https://pubmed.ncbi.nlm.nih.gov/36882456/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,33153494,"EZHIP is a specific diagnostic biomarker for posterior fossa ependymomas, group PFA and diffuse midline gliomas H3-WT with EZHIP overexpression.",2020,10.1186/s40478-020-01056-8,https://pubmed.ncbi.nlm.nih.gov/33153494/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,34759345,Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies.,2022,10.1038/s41388-021-02102-y,https://pubmed.ncbi.nlm.nih.gov/34759345/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,34812989,Molecular subtyping of ependymoma and prognostic impact of Ki-67.,2022,10.1007/s10014-021-00417-y,https://pubmed.ncbi.nlm.nih.gov/34812989/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,34762160,EZHIP: a new piece of the puzzle towards understanding pediatric posterior fossa ependymoma.,2022,10.1007/s00401-021-02382-4,https://pubmed.ncbi.nlm.nih.gov/34762160/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,32197665,Diffuse intrinsic pontine glioma-like tumor with EZHIP expression and molecular features of PFA ependymoma.,2020,10.1186/s40478-020-00905-w,https://pubmed.ncbi.nlm.nih.gov/32197665/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,29909548,Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas.,2018,10.1007/s00401-018-1877-0,https://pubmed.ncbi.nlm.nih.gov/29909548/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,34399838,Characterizing DNA methylation signatures and their potential functional roles in Merkel cell carcinoma.,2021,10.1186/s13073-021-00946-3,https://pubmed.ncbi.nlm.nih.gov/34399838/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,36589281,Oncohistones: Hijacking the histone code.,2022,10.1146/annurev-cancerbio-070120-102521,https://pubmed.ncbi.nlm.nih.gov/36589281/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,34092471,Polycomb repressive complex 2 in the driver's seat of childhood and young adult brain tumours.,2021,10.1016/j.tcb.2021.05.006,https://pubmed.ncbi.nlm.nih.gov/34092471/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,36937401,In vivo loss of tumorigenicity in a patient-derived orthotopic xenograft mouse model of ependymoma.,2023,10.3389/fonc.2023.1123492,https://pubmed.ncbi.nlm.nih.gov/36937401/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,34880314,A proteomics study identifying interactors of the FSHD2 gene product SMCHD1 reveals RUVBL1-dependent DUX4 repression.,2021,10.1038/s41598-021-03030-3,https://pubmed.ncbi.nlm.nih.gov/34880314/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EZHIP,ENSG00000187690,CTA,31451685,EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.,2019,10.1038/s41467-019-11800-x,https://pubmed.ncbi.nlm.nih.gov/31451685/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM170A,ENSG00000164334,CTA,39868537,Fam170a deficiency causes male infertility by impairing histone-to-protamine exchange during mouse spermiogenesis.,2025,10.1093/nar/gkaf023,https://pubmed.ncbi.nlm.nih.gov/39868537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM170A,ENSG00000164334,CTA,42415090,Whole exome sequencing uncovers genetic syndromes and putative candidate genes underlying orofacial clefts presenting with limb abnormalities in a Sub-Saharan African cohort.,2026,10.1186/s12920-026-02426-2,https://pubmed.ncbi.nlm.nih.gov/42415090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM170A,ENSG00000164334,CTA,42274553,Network Toxicology and Transcriptomic Analyses Reveal Ferroptosis-Related Neurotoxicity of Rotenone as an Environmental Hazardous Compound.,2026,10.3390/cells15110959,https://pubmed.ncbi.nlm.nih.gov/42274553/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM170A,ENSG00000164334,CTA,40725194,Mouse PrimPol Outperforms Its Human Counterpart as a Robust DNA Primase.,2025,10.3390/ijms26146947,https://pubmed.ncbi.nlm.nih.gov/40725194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM170A,ENSG00000164334,CTA,42106026,Comparative structural analysis of Nipah virus V proteins highlights V-MDA5 complex stability in pig and bat isolates.,2026,10.1016/j.pep.2026.106948,https://pubmed.ncbi.nlm.nih.gov/42106026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM170A,ENSG00000164334,CTA,32588889,"Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in mice†.",2020,10.1093/biolre/ioaa082,https://pubmed.ncbi.nlm.nih.gov/32588889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM170A,ENSG00000164334,CTA,29608762,The Zn-finger domain of human PrimPol is required to stabilize the initiating nucleotide during DNA priming.,2018,10.1093/nar/gky230,https://pubmed.ncbi.nlm.nih.gov/29608762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM170A,ENSG00000164334,CTA,22231842,Activation of transcriptional activity of HSE by a novel mouse zinc finger protein ZNFD specifically expressed in testis.,2012,10.1007/s11010-011-1193-7,https://pubmed.ncbi.nlm.nih.gov/22231842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM170A,ENSG00000164334,CTA,25371215,Effects of vanadium (V) and magnesium (Mg) on rat bone tissue: mineral status and micromorphology. Consequences of V-Mg interactions.,2014,10.1039/c4mt00234b,https://pubmed.ncbi.nlm.nih.gov/25371215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM170A,ENSG00000164334,CTA,20162441,"Isolation and characterization of a novel zinc finger gene, ZNFD, activating AP1(PMA) transcriptional activities.",2010,10.1007/s11010-010-0401-1,https://pubmed.ncbi.nlm.nih.gov/20162441/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
FAM187B,ENSG00000177558,CTA,40572022,Mouse genome engineering uncovers 18 genes dispensable for male reproduction.,2026,10.1111/andr.70088,https://pubmed.ncbi.nlm.nih.gov/40572022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM187B,ENSG00000177558,CTA,37308678,Integrative analysis of risk factors for immune-related adverse events of checkpoint blockade therapy in cancer.,2023,10.1038/s43018-023-00572-5,https://pubmed.ncbi.nlm.nih.gov/37308678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM187B,ENSG00000177558,CTA,25755691,Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling.,2015,,https://pubmed.ncbi.nlm.nih.gov/25755691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM187B,ENSG00000177558,CTA,23599355,Mobile element scanning (ME-Scan) identifies thousands of novel Alu insertions in diverse human populations.,2013,10.1101/gr.148973.112,https://pubmed.ncbi.nlm.nih.gov/23599355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM228A,ENSG00000186453,CTA,39152463,Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta.,2024,10.1186/s13293-024-00629-9,https://pubmed.ncbi.nlm.nih.gov/39152463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM228A,ENSG00000186453,CTA,35888078,"NSD1 Mutations in Sotos Syndrome Induce Differential Expression of Long Noncoding RNAs, miR646 and Genes Controlling the G2/M Checkpoint.",2022,10.3390/life12070988,https://pubmed.ncbi.nlm.nih.gov/35888078/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM24A,ENSG00000203795,CTA,40572022,Mouse genome engineering uncovers 18 genes dispensable for male reproduction.,2026,10.1111/andr.70088,https://pubmed.ncbi.nlm.nih.gov/40572022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO24,ENSG00000106336,CTA,42168344,Hsa-circ_0081481-miR 3960-FBXO24 regulatory axis in non-obstructive azoospermia identifies potential biomarkers of spermatogenic failure.,2026,10.1038/s41598-026-49620-x,https://pubmed.ncbi.nlm.nih.gov/42168344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO24,ENSG00000106336,CTA,42552308,The deubiquitinase USP4 stabilizes the SCF&lt;sup&gt;FBXO24&lt;/sup&gt; ubiquitin E3 ligase to regulate immunity in experimental pneumonia.,2026,10.1038/s41467-026-75336-7,https://pubmed.ncbi.nlm.nih.gov/42552308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO24,ENSG00000106336,CTA,39163107,FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility.,2024,10.7554/elife.92794,https://pubmed.ncbi.nlm.nih.gov/39163107/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO24,ENSG00000106336,CTA,38470475,FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and male fertility.,2024,10.7554/elife.91666,https://pubmed.ncbi.nlm.nih.gov/38470475/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO24,ENSG00000106336,CTA,41073389,VRK2 targeting potentiates anti-PD-1 immunotherapy in hepatocellular carcinoma through MYC destabilization.,2025,10.1038/s41467-025-64079-6,https://pubmed.ncbi.nlm.nih.gov/41073389/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO24,ENSG00000106336,CTA,40764992,"Ivabradine induces RAD51 degradation, potentiating PARP inhibitor efficacy in non-germline BRCA pathogenic variant triple-negative breast cancer.",2025,10.1186/s12967-025-06902-8,https://pubmed.ncbi.nlm.nih.gov/40764992/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO24,ENSG00000106336,CTA,39039092,Targeted degradation of extracellular mitochondrial aspartyl-tRNA synthetase modulates immune responses.,2024,10.1038/s41467-024-50031-7,https://pubmed.ncbi.nlm.nih.gov/39039092/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO24,ENSG00000106336,CTA,37540490,FBXO24 Suppresses Breast Cancer Tumorigenesis by Targeting LSD1 for Ubiquitination.,2023,10.1158/1541-7786.mcr-23-0169,https://pubmed.ncbi.nlm.nih.gov/37540490/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO24,ENSG00000106336,CTA,38735474,FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration.,2024,10.1016/j.jbc.2024.107359,https://pubmed.ncbi.nlm.nih.gov/38735474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO24,ENSG00000106336,CTA,32828318,SCF-FBXO24 regulates cell proliferation by mediating ubiquitination and degradation of PRMT6.,2020,10.1016/j.bbrc.2020.06.007,https://pubmed.ncbi.nlm.nih.gov/32828318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO24,ENSG00000106336,CTA,25582197,The ubiquitin E3 ligase SCF-FBXO24 recognizes deacetylated nucleoside diphosphate kinase A to enhance its degradation.,2015,10.1128/mcb.01185-14,https://pubmed.ncbi.nlm.nih.gov/25582197/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO24,ENSG00000106336,CTA,23324393,An SCF complex containing Fbxl12 mediates DNA damage-induced Ku80 ubiquitylation.,2013,10.4161/cc.23408,https://pubmed.ncbi.nlm.nih.gov/23324393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO39,ENSG00000177294,CTA,41916926,Testis-Enriched F-Box Protein FBXO39 Is Important for Spermiogenesis and Male Fertility in Mice.,2026,10.1111/andr.70225,https://pubmed.ncbi.nlm.nih.gov/41916926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO39,ENSG00000177294,CTA,41781602,FBXO39 knockdown promotes spermatogenesis impairment by inducing mitochondrial dysfunction and ferroptosis via inhibiting KDM5A ubiquitination and regulating H3K4me3 demethylation.,2026,10.1007/s10565-026-10167-2,https://pubmed.ncbi.nlm.nih.gov/41781602/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO39,ENSG00000177294,CTA,40504854,Cancer/testis antigens FBXO39 and CEP55 expression correlates with survival in GBM patients.,2025,10.1371/journal.pone.0326054,https://pubmed.ncbi.nlm.nih.gov/40504854/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO39,ENSG00000177294,CTA,41923267,FBXO39 promotes LDHA-mediated aerobic glycolysis and colorectal cancer progression by p53 degradation.,2026,10.1186/s12967-026-08056-7,https://pubmed.ncbi.nlm.nih.gov/41923267/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO39,ENSG00000177294,CTA,40599850,Design and immunogenic evaluation of multi-epitope vaccines for colorectal cancer: insights from molecular dynamics and &lt;i&gt;In-Vitro&lt;/i&gt; studies.,2025,10.3389/fonc.2025.1592072,https://pubmed.ncbi.nlm.nih.gov/40599850/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO39,ENSG00000177294,CTA,36244247,The cancer-testis antigen FBXO39 predicts poor prognosis and is associated with stemness and aggressiveness in glioma.,2022,10.1016/j.prp.2022.154168,https://pubmed.ncbi.nlm.nih.gov/36244247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO39,ENSG00000177294,CTA,34380828,Significance of cancer testis-associated antigens (SPAG9 and FBXO39) in colon cancer.,2022,10.4103/ijc.ijc_873_19,https://pubmed.ncbi.nlm.nih.gov/34380828/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO39,ENSG00000177294,CTA,36049441,FBXO39 predicts poor prognosis and correlates with tumor progression in cervical squamous cell carcinoma.,2022,10.1016/j.prp.2022.154090,https://pubmed.ncbi.nlm.nih.gov/36049441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO39,ENSG00000177294,CTA,32902238,Aberrant Expression of Cancer-Testis Antigen FBXO39 in Breast Cancer and its Clinical Significance.,2020,10.7754/clin.lab.2020.200121,https://pubmed.ncbi.nlm.nih.gov/32902238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO39,ENSG00000177294,CTA,37366074,Integrating sperm cell transcriptome and seminal plasma metabolome to analyze the molecular regulatory mechanism of sperm motility in Holstein stud bulls.,2023,10.1093/jas/skad214,https://pubmed.ncbi.nlm.nih.gov/37366074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO39,ENSG00000177294,CTA,29802700,Prognostic Value of FBXO39 and ETS-1 but not BMI-1 in Iranian Colorectal Cancer Patients,2018,10.22034/apjcp.2018.19.5.1357,https://pubmed.ncbi.nlm.nih.gov/29802700/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO39,ENSG00000177294,CTA,36349462,Comprehensive analysis of HHV-6 and HHV-7-related gene signature in prognosis and response to temozolomide of glioma.,2023,10.1002/jmv.28285,https://pubmed.ncbi.nlm.nih.gov/36349462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO39,ENSG00000177294,CTA,30008875,Knockdown of FBXO39 inhibits proliferation and promotes apoptosis of human osteosarcoma U-2OS cells.,2018,10.3892/ol.2018.8876,https://pubmed.ncbi.nlm.nih.gov/30008875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO39,ENSG00000177294,CTA,36183674,FBXL6 depletion restrains clear cell renal cell carcinoma progression.,2022,10.1016/j.tranon.2022.101550,https://pubmed.ncbi.nlm.nih.gov/36183674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO39,ENSG00000177294,CTA,24377578,"Expression analysis of two cancer-testis genes, FBXO39 and TDRD4, in breast cancer tissues and cell lines.",2014,10.7314/apjcp.2013.14.11.6625,https://pubmed.ncbi.nlm.nih.gov/24377578/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO39,ENSG00000177294,CTA,27635108,Expression of Cancer Testis Antigens in Colorectal Cancer: New Prognostic and Therapeutic Implications.,2016,10.1155/2016/1987505,https://pubmed.ncbi.nlm.nih.gov/27635108/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO39,ENSG00000177294,CTA,21338577,Identification of BCP-20 (FBXO39) as a cancer/testis antigen from colon cancer patients by SEREX.,2011,10.1016/j.bbrc.2011.02.077,https://pubmed.ncbi.nlm.nih.gov/21338577/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO39,ENSG00000177294,CTA,26537429,Integrated Genome-wide association and hypothalamus eQTL studies indicate a link between the circadian rhythm-related gene PER1 and coping behavior.,2015,10.1038/srep16264,https://pubmed.ncbi.nlm.nih.gov/26537429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,41185558,VSIG2 hinders gastric cancer progression by suppressing ANXA2-mediated NF-κB pathway activation.,2025,10.3724/abbs.2025202,https://pubmed.ncbi.nlm.nih.gov/41185558/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,39875985,ZNF169 promotes thyroid cancer progression via upregulating FBXW10.,2025,10.1186/s13008-024-00139-5,https://pubmed.ncbi.nlm.nih.gov/39875985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,41749864,"Pimozide Reprograms the Ran GTPase-SCF Axis and Matrix Remodeling Pathways in Breast, Colorectal, and Pancreatic Cancer Models.",2026,10.3390/cancers18040611,https://pubmed.ncbi.nlm.nih.gov/41749864/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,41626181,Identify and validate a novel ubiquitination-related biomarker for thyroid cancer prognosis and immunotherapy.,2025,10.3389/fonc.2025.1542784,https://pubmed.ncbi.nlm.nih.gov/41626181/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,42024100,Whole genome sequencing analysis of over 3500 individuals dementia-free over 85 years old.,2026,10.1177/13872877261444302,https://pubmed.ncbi.nlm.nih.gov/42024100/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,36990424,The E3 ubiquitin ligase SCF (FBXW10)-mediated LATS2 degradation regulates angiogenesis and liver metastasis in colorectal cancer.,2023,10.1016/j.biocel.2023.106408,https://pubmed.ncbi.nlm.nih.gov/36990424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,37277019,FBXW10-S6K1 promotes ANXA2 polyubiquitination and KRAS activation to drive hepatocellular carcinoma development in males.,2023,10.1016/j.canlet.2023.216257,https://pubmed.ncbi.nlm.nih.gov/37277019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,37450367,Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.,2023,10.1016/j.celrep.2023.112812,https://pubmed.ncbi.nlm.nih.gov/37450367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,37175943,Novel Susceptibility Genes Drive Familial Non-Medullary Thyroid Cancer in a Large Consanguineous Kindred.,2023,10.3390/ijms24098233,https://pubmed.ncbi.nlm.nih.gov/37175943/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,31400758,FBXW10 promotes hepatocarcinogenesis in male patients and mice.,2020,10.1093/carcin/bgz138,https://pubmed.ncbi.nlm.nih.gov/31400758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,35909123,Identification of immune-related and autophagy-related genes for the prediction of survival in bladder cancer.,2022,10.1186/s12863-022-01073-7,https://pubmed.ncbi.nlm.nih.gov/35909123/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,26722292,"Abnormal methylation status of FBXW10 and SMPD3, and associations with clinical characteristics in clear cell renal cell carcinoma.",2015,10.3892/ol.2015.3707,https://pubmed.ncbi.nlm.nih.gov/26722292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,31712638,"KMT2C, a histone methyltransferase, is mutated in a family segregating non-syndromic primary failure of tooth eruption.",2019,10.1038/s41598-019-52935-7,https://pubmed.ncbi.nlm.nih.gov/31712638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,28397399,Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma.,2017,10.1002/1878-0261.12064,https://pubmed.ncbi.nlm.nih.gov/28397399/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,23899520,FBXW10 is negatively regulated in transcription and expression level by protein O-GlcNAcylation.,2013,10.1016/j.bbrc.2013.07.091,https://pubmed.ncbi.nlm.nih.gov/23899520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,20498703,"Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10.",2010,10.1371/journal.pone.0010620,https://pubmed.ncbi.nlm.nih.gov/20498703/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,24825865,Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia.,2014,10.1182/blood-2014-03-559542,https://pubmed.ncbi.nlm.nih.gov/24825865/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,22382637,Lamin misexpression upregulates three distinct ubiquitin ligase systems that degrade ATR kinase in HeLa cells.,2012,10.1007/s11010-012-1272-4,https://pubmed.ncbi.nlm.nih.gov/22382637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXW10,ENSG00000171931,CTA,22194858,Reduction in inflammatory gene expression in skeletal muscle from Roux-en-Y gastric bypass patients randomized to omentectomy.,2011,10.1371/journal.pone.0028577,https://pubmed.ncbi.nlm.nih.gov/22194858/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,41292695,"A Del(5&lt;i&gt;Ncf1&lt;/i&gt;-&lt;i&gt;Fkbp6&lt;/i&gt;) mouse model of Williams syndrome shows coronary, aortic, and cerebral vascular abnormalities with behavioral deficits.",2025,10.1093/pnasnexus/pgaf359,https://pubmed.ncbi.nlm.nih.gov/41292695/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,42059593,"The synaptonemal complex: structure, function, and clinical implications†.",2026,10.1093/biolre/ioag092,https://pubmed.ncbi.nlm.nih.gov/42059593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,41845159,"Modeling Williams syndrome from a neurodevelopmental perspective: recent advances, model-based translational insights and future directions.",2026,10.1007/s12519-026-01020-x,https://pubmed.ncbi.nlm.nih.gov/41845159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,39734607,The Antioxidant and Anti-Inflammatory Impacts of Purple and White Eggplants on Fertility and Expression of Fertility-Related Genes in Rats Treated With Aluminum Chloride.,2024,10.1155/jt/8215321,https://pubmed.ncbi.nlm.nih.gov/39734607/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,36150389,The piRNA-pathway factor FKBP6 is essential for spermatogenesis but dispensable for control of meiotic LINE-1 expression in humans.,2022,10.1016/j.ajhg.2022.09.002,https://pubmed.ncbi.nlm.nih.gov/36150389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,41895103,Causal relationship between genetically predicted Enzyme and Tinnitus risk: a two-sample bi-directional mendelian randomization study.,2026,10.1016/j.bjorl.2026.101804,https://pubmed.ncbi.nlm.nih.gov/41895103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,42315506,Genetic and health determinants of cancer risk in Bangladeshi and Pakistani individuals in the UK.,2026,10.1038/s41467-026-74415-z,https://pubmed.ncbi.nlm.nih.gov/42315506/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,39490453,Spermatozoal acrosome dysfunction and its role in stallion subfertility.,2024,10.1016/j.jevs.2024.105213,https://pubmed.ncbi.nlm.nih.gov/39490453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,37459509,In vivo versus in silico assessment of potentially pathogenic missense variants in human reproductive genes.,2023,10.1073/pnas.2219925120,https://pubmed.ncbi.nlm.nih.gov/37459509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,38092774,Analyzing aberrant DNA methylation in colorectal cancer uncovered intangible heterogeneity of gene effects in the survival time of patients.,2023,10.1038/s41598-023-47377-1,https://pubmed.ncbi.nlm.nih.gov/38092774/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,40439417,CervicalMethDx: A Precision DNA Methylation Test to Identify Risk of High-Grade Intraepithelial Lesions in Cervical Cancer Screening Algorithms.,2025,10.1158/1940-6207.capr-25-0029,https://pubmed.ncbi.nlm.nih.gov/40439417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,36552460,Expression Profile of Housekeeping Genes and Tissue-Specific Genes in Multiple Tissues of Pigs.,2022,10.3390/ani12243539,https://pubmed.ncbi.nlm.nih.gov/36552460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,38816557,Proteomic analysis of sperm from fertile stallions and subfertile stallions due to impaired acrosomal exocytosis.,2024,10.1038/s41598-024-63410-3,https://pubmed.ncbi.nlm.nih.gov/38816557/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,39358566,Comprehensive analysis of chromosomal breakpoints and candidate genes associated with male infertility: insights from cytogenetic studies and expression analyses.,2024,10.1007/s00335-024-10074-z,https://pubmed.ncbi.nlm.nih.gov/39358566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,31037925,Comparison of Germ Cell Gene Expressions in Spontaneous Monolayer versus Embryoid Body Differentiation of Mouse Embryonic Stem Cells toward Germ Cells.,2019,10.22074/ijfs.2019.5557,https://pubmed.ncbi.nlm.nih.gov/31037925/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,30288485,Evaluation of specific germ cell genes expression in mouse embryonic stem cell-derived germ cell like cells treated with bone morphogenetic protein 4 in vitro.,2018,10.29252/ijrm.16.8.507,https://pubmed.ncbi.nlm.nih.gov/30288485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,29635292,Comparative whole genome DNA methylation profiling of cattle sperm and somatic tissues reveals striking hypomethylated patterns in sperm.,2018,10.1093/gigascience/giy039,https://pubmed.ncbi.nlm.nih.gov/29635292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,33238277,Fertility Relevance Probability Analysis Shortlists Genetic Markers for Male Fertility Impairment.,2020,10.1159/000511117,https://pubmed.ncbi.nlm.nih.gov/33238277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,32141383,Promoter hypermethylation of PIWI/piRNA pathway genes associated with diminished pachytene piRNA production in bovine hybrid male sterility.,2020,10.1080/15592294.2020.1738026,https://pubmed.ncbi.nlm.nih.gov/32141383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,27658575,Differential DNA methylation of the meiosis-specific gene FKBP6 in testes of yak and cattle-yak hybrids.,2016,10.1111/rda.12794,https://pubmed.ncbi.nlm.nih.gov/27658575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,26567527,Involvement of FKBP6 in hepatitis C virus replication.,2015,10.1038/srep16699,https://pubmed.ncbi.nlm.nih.gov/26567527/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FKBP6,ENSG00000077800,CTA,27671338,"Molecular Triage of Premalignant Lesions in Liquid-Based Cervical Cytology and Circulating Cell-Free DNA from Urine, Using a Panel of Methylated Human Papilloma Virus and Host Genes.",2016,10.1158/1940-6207.capr-16-0138,https://pubmed.ncbi.nlm.nih.gov/27671338/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMR1NB,ENSG00000176988,CTA,42899482,Tumour Antigen-Specific Antibody Signatures as Diagnostic Biomarkers for Melanoma.,2026,10.1002/ijc.70726,https://pubmed.ncbi.nlm.nih.gov/42899482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMR1NB,ENSG00000176988,CTA,41091706,"A survey of human cancer-germline genes: Linking X chromosome localization, DNA methylation and sex-biased expression in early embryos.",2025,10.1371/journal.pgen.1011734,https://pubmed.ncbi.nlm.nih.gov/41091706/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMR1NB,ENSG00000176988,CTA,38214607,Efficacy against Lung Cancer Is Augmented by Combining Aberrantly N-Glycosylated T Cells with a Chimeric Antigen Receptor Targeting Fragile X Mental Retardation 1 Neighbor.,2024,10.4049/jimmunol.2300618,https://pubmed.ncbi.nlm.nih.gov/38214607/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMR1NB,ENSG00000176988,CTA,35819657,FMR1NB Involved in Glioma Tumorigenesis Is a Promising Target for Prognosis and Therapy.,2022,10.1007/s11596-022-2586-4,https://pubmed.ncbi.nlm.nih.gov/35819657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMR1NB,ENSG00000176988,CTA,36017582,Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia.,2022,10.1111/andr.13269,https://pubmed.ncbi.nlm.nih.gov/36017582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMR1NB,ENSG00000176988,CTA,34719679,Discovery of new genetic loci for male sexual orientation in Han population.,2021,10.1038/s41421-021-00341-7,https://pubmed.ncbi.nlm.nih.gov/34719679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMR1NB,ENSG00000176988,CTA,31562180,Genomic Structure of Hstx2 Modifier of Prdm9-Dependent Hybrid Male Sterility in Mice.,2019,10.1534/genetics.119.302554,https://pubmed.ncbi.nlm.nih.gov/31562180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMR1NB,ENSG00000176988,CTA,22869527,Multiple cancer testis antigens function to support tumor cell mitotic fidelity.,2012,10.1128/mcb.00686-12,https://pubmed.ncbi.nlm.nih.gov/22869527/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMR1NB,ENSG00000176988,CTA,23307483,Xq27 FRAXA locus is a strong candidate for dyslexia: evidence from a genome-wide scan in French families.,2013,10.1007/s10519-012-9575-5,https://pubmed.ncbi.nlm.nih.gov/23307483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMR1NB,ENSG00000176988,CTA,12601173,Immunomic analysis of human sarcoma.,2003,10.1073/pnas.0437972100,https://pubmed.ncbi.nlm.nih.gov/12601173/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FNDC8,ENSG00000073598,CTA,41169243,Perinuclear theca protein FNDC8 interacts with CCIN and ACTL7A to ensure proper sperm head shaping during spermiogenesis.,2025,10.24272/j.issn.2095-8137.2025.060,https://pubmed.ncbi.nlm.nih.gov/41169243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FNDC8,ENSG00000073598,CTA,36626432,Expression and prognosis analyses of the fibronectin type-III domain-containing (FNDC) protein family in human cancers: A Review.,2022,10.1097/md.0000000000031854,https://pubmed.ncbi.nlm.nih.gov/36626432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42454015,LC-IL but Not LC-PL Circuit Regulates Comorbid Mechanical Hyperalgesia and Anxiety in Male Rats with Chronic Post-Surgical Pain.,2026,10.2147/jpr.s585416,https://pubmed.ncbi.nlm.nih.gov/42454015/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42761819,T cell-dependent modulation of pain behaviors in a rat model of recurring paclitaxel-induced peripheral neuropathy.,2026,10.1016/j.bbih.2026.101349,https://pubmed.ncbi.nlm.nih.gov/42761819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42198369,Persistent Mu-Opioid Receptor Dysregulation in a Pain-Facilitatory Brain Region Reinstates Hyperalgesia After Resolution of Opioid-Induced Hyperalgesia.,2026,10.3390/ph19050695,https://pubmed.ncbi.nlm.nih.gov/42198369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42192353,Elevated TRPV1 expression in the central nucleus of the amygdala participates in initial pain and subsequent anxiety-related behaviors in mice undergoing orthodontic tooth movement.,2026,10.1186/s12903-026-08652-5,https://pubmed.ncbi.nlm.nih.gov/42192353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42499765,Bilateral infantile Frey syndrome mimicking food allergy: A case report.,2026,10.1002/ped4.70059,https://pubmed.ncbi.nlm.nih.gov/42499765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42543110,Blockade of semaphorin 3E attenuates neuroinflammation and mechanical hypersensitivity: implications for neuropathic pain therapy.,2026,10.1016/j.bbi.2026.106940,https://pubmed.ncbi.nlm.nih.gov/42543110/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42576205,Botulinum toxin type A attenuates trigeminal neuralgia-like pain by suppressing CGRP release and modulating NaV1.7-associated signaling.,2026,10.1186/s10194-026-02454-4,https://pubmed.ncbi.nlm.nih.gov/42576205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,41656233,Effects of electroacupuncture at Zusanli on pain-perception-related brain nuclei in KOA mice: a study on cortical and subcortical c-fos expression.,2026,10.1186/s12993-026-00322-4,https://pubmed.ncbi.nlm.nih.gov/41656233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42573969,An NLRP3 inflammasome inhibitor evoked dose-dependent anti-allodynia in the hindpaws of a rat model of chemotherapy-induced peripheral neuropathy.,2026,10.1007/s10787-026-02360-w,https://pubmed.ncbi.nlm.nih.gov/42573969/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,35960805,C11orf94/Frey is a key regulator for male fertility by controlling Izumo1 complex assembly.,2022,10.1126/sciadv.abo6049,https://pubmed.ncbi.nlm.nih.gov/35960805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42376060,Antioxidant Therapy Reverses Sound Stress-Induced Opioid Resistance in a Mouse Model of Mechanical Allodynia.,2026,10.2147/jpr.s550094,https://pubmed.ncbi.nlm.nih.gov/42376060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42117099,Transcranial Direct Current Stimulation Targeting the Primary Motor Cortex Suppresses Activity in the Ventrolateral Periaqueductal Gray and Alleviates Chronic Pain in a Rat Model of Knee Osteoarthritis.,2026,10.2147/jpr.s595212,https://pubmed.ncbi.nlm.nih.gov/42117099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42010257,Transcriptomic profiling of the central amygdala in a rat model of diabetes-associated neuropathic pain.,2026,10.1038/s41597-026-07292-2,https://pubmed.ncbi.nlm.nih.gov/42010257/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42494179,Passive Oscillatory Body Motion Attenuates Pain-Related Behaviors and Increases β-Endorphin Immunoreactivity in a Murine Fracture Model: A Preliminary Study.,2026,10.1002/brb3.71614,https://pubmed.ncbi.nlm.nih.gov/42494179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42238956,Synovial macrophage-targeted hierarchical microspheres achieve cartilage preservation and pain relief in osteoarthritis.,2026,10.1016/j.mtbio.2026.103178,https://pubmed.ncbi.nlm.nih.gov/42238956/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42337655,"Bortezomib-induced gastrointestinal dysfunction, peripheral neuropathy and neuroimmune signalling are influenced by the gut microbiota in mice.",2026,10.1186/s12974-026-03909-w,https://pubmed.ncbi.nlm.nih.gov/42337655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42515756,Neuroprotective Effects of Choline Alfoscerate in Experimental Diabetic Peripheral Neuropathy.,2026,10.3390/ph19071076,https://pubmed.ncbi.nlm.nih.gov/42515756/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42339483,Mechanism of electrothermal acupuncture in alleviating postherpetic neuralgia.,2026,10.3389/fneur.2026.1750292,https://pubmed.ncbi.nlm.nih.gov/42339483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,41782882,Oxymatrine alleviates symptoms in high-fat diet and STZ-induced SD rats with painful diabetic neuropathy by reducing inflammation and oxidative stress.,2026,10.3389/fimmu.2026.1750051,https://pubmed.ncbi.nlm.nih.gov/41782882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,41008336,Electroacupuncture Attenuates Fibromyalgia Pain Through Increased PD-1 Expression in Female Mice.,2025,10.3390/brainsci15090976,https://pubmed.ncbi.nlm.nih.gov/41008336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42635867,Short-term outcomes of robotic-assisted versus open Frey procedure in chronic pancreatitis: a single-center retrospective cohort study.,2026,10.1007/s11701-026-03812-9,https://pubmed.ncbi.nlm.nih.gov/42635867/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42848373,"Muffly L, Frey NV, Roloff GW, et al. Consensus recommendations for CAR T-cell administration in adult acute lymphoblastic leukemia: a modified Delphi study. Blood. 2026;148(6):657-668.",2026,10.1182/blood.2026036233,https://pubmed.ncbi.nlm.nih.gov/42848373/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42532226,A phytotherapeutic candidate for neuropathic pain: Helicteres ovata (Lam.) extract shows antinociceptive effects and favorable acute toxicity profile.,2027,10.1016/j.jep.2026.122251,https://pubmed.ncbi.nlm.nih.gov/42532226/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42057908,Frey Syndrome: A Novel Classification System Based on Symptom Severity.,2026,10.1002/lio2.70378,https://pubmed.ncbi.nlm.nih.gov/42057908/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42200965,Combined BTX-A and Collagen Membrane in Benign Parotid Enucleation: A Comparative Cohort Study.,2026,10.3390/cmtr19020023,https://pubmed.ncbi.nlm.nih.gov/42200965/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42653732,Etoricoxib-Betamethasone Combination Attenuates Inflammatory Nociception and Edema in Adjuvant-Induced Arthritis via Cytokine and Macrophage Axis Modulation.,2026,10.3390/ph19081235,https://pubmed.ncbi.nlm.nih.gov/42653732/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42115926,Effects of single and combination dosage regimens of ketorolac and dexmedetomidine on allodynia and nociception in rat model of osteoarthritis: an animal multi-group trial.,2026,10.1186/s12871-026-03770-7,https://pubmed.ncbi.nlm.nih.gov/42115926/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42270747,Analgesic effects of human placental hydrolysate on capsaicin-induced hyperalgesia in rats.,2026,10.1038/s41598-026-51520-z,https://pubmed.ncbi.nlm.nih.gov/42270747/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42317367,A C57BL/6N mice model of CP/CPPS established by prostate antigen immunization with DPT and BCG co-administration.,2026,10.3389/fimmu.2026.1779951,https://pubmed.ncbi.nlm.nih.gov/42317367/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,40496509,Preclinical efficacy and safety assessments of Adult human neural stem cells (AhNSCs) for spinal cord injury.,2025,10.1016/j.toxrep.2025.102048,https://pubmed.ncbi.nlm.nih.gov/40496509/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42792673,Antinociceptive Effects of Free and β-Cyclodextrin-Associated α-Phellandrene in CFA-Induced Inflammatory Pain.,2026,10.3390/biomedicines14091932,https://pubmed.ncbi.nlm.nih.gov/42792673/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,41808026,Effect of preoperative ultrasound-guided stellate ganglion block on pain thresholds and postoperative nausea and vomiting in gynecological laparoscopy: a randomised clinical trial.,2026,10.1186/s12871-026-03752-9,https://pubmed.ncbi.nlm.nih.gov/41808026/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,41300670,Efficacy of Endoscopic Retrograde Cholangiopancreatography and Frey Procedure in the Treatment of Pediatric Pancreatic Duct Stones: A Single-Center Retrospective Cohort Study.,2025,10.3390/children12111555,https://pubmed.ncbi.nlm.nih.gov/41300670/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,41499049,Dexmedetomidine Mitigates Sevoflurane-Induced Neurodevelopmental Effects in Paediatric Anaesthesia: A Meta-Analysis and Preclinical Study.,2026,10.1007/s11481-025-10273-8,https://pubmed.ncbi.nlm.nih.gov/41499049/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,41022524,Intra-articular sustained-release colchicine is efficacious in an inflammatory arthritis rat model.,2025,10.1136/rmdopen-2025-005988,https://pubmed.ncbi.nlm.nih.gov/41022524/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42660256,A Comparative Evaluation of Fibrosis in Patients With and Without Chronic Pancreatitis Undergoing Pancreatic Surgery.,2026,10.1016/j.cgh.2026.08.015,https://pubmed.ncbi.nlm.nih.gov/42660256/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,41759689,Safety assessment of a soft metal-free silicone peripheral nerve cuff implanted in rat models of neuropathic and inflammatory pain.,2026,10.1016/j.jpain.2026.106232,https://pubmed.ncbi.nlm.nih.gov/41759689/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,37261541,The transmembrane domain of Frey1 harbors a transplantable inhibitory motif for intramembrane proteases.,2023,10.1007/s00018-023-04823-7,https://pubmed.ncbi.nlm.nih.gov/37261541/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FREY1,ENSG00000234776,CTA,42846857,"Analgesic effect of methadone constant rate infusion is not superior to fentanyl constant rate infusion in dogs after spinal surgery: a prospective, randomized, blinded, clinical trial.",2026,10.3389/fvets.2026.1873178,https://pubmed.ncbi.nlm.nih.gov/42846857/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCB,ENSG00000189139,CTA,39336733,Genomic Regions Associated with Growth and Reproduction Traits in Pink-Eyed White Mink.,2024,10.3390/genes15091142,https://pubmed.ncbi.nlm.nih.gov/39336733/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCB,ENSG00000189139,CTA,36054039,"Tomato spotted wilt orthotospovirus shifts sex ratio toward males in the western flower thrips, Frankliniella occidentalis, by down-regulating a FSCB-like gene.",2022,10.1002/ps.7125,https://pubmed.ncbi.nlm.nih.gov/36054039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCB,ENSG00000189139,CTA,36830929,Decreased Maternal Morbidity and Improved Perinatal Results of Magnesium-Free Tocolysis and Classical Hysterotomy in Fetal Open Surgery for Myelomeningocele Repair: A Single-Center Study.,2023,10.3390/biomedicines11020392,https://pubmed.ncbi.nlm.nih.gov/36830929/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCB,ENSG00000189139,CTA,25767810,Fan-shaped complete block on helical tomotherapy for esophageal cancer: a phantom study.,2015,10.1155/2015/959504,https://pubmed.ncbi.nlm.nih.gov/25767810/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCB,ENSG00000189139,CTA,23303679,"Loss of R2D2 proteins ROPN1 and ROPN1L causes defects in murine sperm motility, phosphorylation, and fibrous sheath integrity.",2013,10.1095/biolreprod.112.105262,https://pubmed.ncbi.nlm.nih.gov/23303679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCB,ENSG00000189139,CTA,17855365,"FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis.",2007,10.1074/jbc.m702238200,https://pubmed.ncbi.nlm.nih.gov/17855365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCB,ENSG00000189139,CTA,27440996,"Variation in PTCHD2, CRISP3, NAP1L4, FSCB, and AP3B2 associated with spherical equivalent.",2016,,https://pubmed.ncbi.nlm.nih.gov/27440996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCB,ENSG00000189139,CTA,23695280,Rare copy number variation in cerebral palsy.,2014,10.1038/ejhg.2013.93,https://pubmed.ncbi.nlm.nih.gov/23695280/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCB,ENSG00000189139,CTA,25575546,"Production of the antibiotic FR-008/candicidin in Streptomyces sp. FR-008 is co-regulated by two regulators, FscRI and FscRIV, from different transcription factor families.",2015,10.1099/mic.0.000033,https://pubmed.ncbi.nlm.nih.gov/25575546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCB,ENSG00000189139,CTA,22006429,High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes.,2012,10.1002/cncr.26617,https://pubmed.ncbi.nlm.nih.gov/22006429/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCN3,ENSG00000106328,CTA,37891374,Identification of hub genes associated with spermatogenesis by bioinformatics analysis.,2023,10.1038/s41598-023-45620-3,https://pubmed.ncbi.nlm.nih.gov/37891374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCN3,ENSG00000106328,CTA,37559574,"Comprehensive analysis of the expression, prognosis and biological significance of FSCN family in clear cell renal cell carcinoma.",2023,10.3892/ol.2023.13965,https://pubmed.ncbi.nlm.nih.gov/37559574/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCN3,ENSG00000106328,CTA,35449315,Testis-specific fascin component FSCN3 is dispensable for mouse spermatogenesis and fertility.,2022,10.1007/s11033-022-07429-7,https://pubmed.ncbi.nlm.nih.gov/35449315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCN3,ENSG00000106328,CTA,42511094,Genetic Ancestry and Genome-Wide Association Study Combined with Functional Enrichment Analyses Reveal Candidate Genes for Body Conformation Traits in Hexi Cattle.,2026,10.3390/ani16142216,https://pubmed.ncbi.nlm.nih.gov/42511094/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCN3,ENSG00000106328,CTA,33791879,"Impact of platelet-rich plasma versus selenium in ameliorating induced toxicity in rat testis: histological, immunohistochemical, and molecular study.",2021,10.1007/s00441-021-03439-2,https://pubmed.ncbi.nlm.nih.gov/33791879/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCN3,ENSG00000106328,CTA,37895311,Multi-Trait Exome-Wide Association Study of Back Pain-Related Phenotypes.,2023,10.3390/genes14101962,https://pubmed.ncbi.nlm.nih.gov/37895311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCN3,ENSG00000106328,CTA,31005359,Identification of candidate genes in regulation of spermatogenesis in sheep testis following dietary vitamin E supplementation.,2019,10.1016/j.anireprosci.2019.04.003,https://pubmed.ncbi.nlm.nih.gov/31005359/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCN3,ENSG00000106328,CTA,24012201,Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis.,2013,10.1016/j.fertnstert.2013.07.1999,https://pubmed.ncbi.nlm.nih.gov/24012201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCN3,ENSG00000106328,CTA,17065803,"Characterization of the porcine FSCN3 gene: cDNA cloning, genomic structure, mapping and polymorphisms.",2006,10.1159/000095242,https://pubmed.ncbi.nlm.nih.gov/17065803/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSCN3,ENSG00000106328,CTA,11925108,Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head.,2002,10.1006/excr.2002.5486,https://pubmed.ncbi.nlm.nih.gov/11925108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,42546419,Paternal exposure to polystyrene nanoplastics induces inter- and transgenerational bronchopulmonary dysplasia-like damage in male offspring by FtMt hypermethylation-mediated ferroptosis.,2026,10.1016/j.redox.2026.104331,https://pubmed.ncbi.nlm.nih.gov/42546419/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,41844496,The regulation of mitochondrial ferritin on mitochondrial redox balance is essential to cell fate decision.,2026,10.1016/j.redox.2026.104124,https://pubmed.ncbi.nlm.nih.gov/41844496/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,41415578,Gallic acid attenuates diabetic cardiomyopathy by inhibiting ferroptosis and protecting mitochondria via the TSPO/FTMT pathway.,2025,10.3389/fphar.2025.1661144,https://pubmed.ncbi.nlm.nih.gov/41415578/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,42304365,"An integrative framework combining Mendelian randomization, single-cell profiling, and experimental validation identifies FTMT as a mitochondrial-immune regulator in non-small cell lung cancer.",2026,10.1186/s12935-026-04387-z,https://pubmed.ncbi.nlm.nih.gov/42304365/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,41990575,FTMT-mediated suppression of mitophagy links iron accumulation to osteoporosis.,2026,10.1016/j.redox.2026.104157,https://pubmed.ncbi.nlm.nih.gov/41990575/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,41789474,Nrf2 attenuates diquat-induced renal ferroptosis by regulating mitochondrial ferritin.,2026,10.1080/15376516.2026.2641204,https://pubmed.ncbi.nlm.nih.gov/41789474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,41164223,Altered Iron Regulation and the Role of Ferritin Heavy Chain in Dermatomyositis Patients.,2025,10.2147/jir.s517067,https://pubmed.ncbi.nlm.nih.gov/41164223/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,40551312,Mitochondrial Ferritin Overexpression Attenuates Ferroptosis and Mitochondrial Dysfunction by Reducing VDAC1 to Relieve MI/RI-Induced Damage.,2025,10.1111/jcmm.70650,https://pubmed.ncbi.nlm.nih.gov/40551312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,41903614,Novel bisphosphonate derivative partially attenuates iron-associated oxidative stress in doxorubicin-induced testicular injury.,2026,10.1016/j.reprotox.2026.109229,https://pubmed.ncbi.nlm.nih.gov/41903614/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,42586456,Hematology-centered characterization of systemic physiological alterations during viral haemorrhagic septicemia virus (VHSV) infection in olive flounder (Paralichthys olivaceus).,2026,10.1016/j.fsi.2026.111645,https://pubmed.ncbi.nlm.nih.gov/42586456/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,41374003,Ferritin Mitochondrial (FTMT)-Driven Mitochondrial Ferroptosis in Vascular Smooth Muscle Cells: A Role of NCOA4 in Atherosclerosis Pathogenesis and Modulation by Gualou-Xiebai.,2025,10.3390/nu17233713,https://pubmed.ncbi.nlm.nih.gov/41374003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,38988693,Immunohistochemical Study of Human Mitochondrial Ferritin in the Substantia Nigra Following Subarachnoid Hemorrhage.,2024,10.1267/ahc.24-00002,https://pubmed.ncbi.nlm.nih.gov/38988693/,normal,Discussed in explicit gene adjudication; see its review depth and limitations
FTMT,ENSG00000181867,CTA,42004955,Ferroptosis inhibition and AMPK activation: key mechanisms of soy isoflavones against cerebral injury.,2026,10.3389/fimmu.2026.1663986,https://pubmed.ncbi.nlm.nih.gov/42004955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,39318194,Mitochondrial ferritin upregulation by deferiprone reduced neuronal ferroptosis and improved neurological deficits via NDRG1/Yap pathway in a neonatal rat model of germinal matrix hemorrhage.,2025,10.1177/0271678x241252110,https://pubmed.ncbi.nlm.nih.gov/39318194/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,41608289,Real-world comparison of mechanical thrombectomy vs. catheter-directed thrombolysis for the treatment of pulmonary embolism: a single-center retrospective study.,2025,10.3389/fcvm.2025.1711473,https://pubmed.ncbi.nlm.nih.gov/41608289/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,37124956,Immunohistochemical Analysis of Mitochondrial Ferritin in the Midbrain of Patients with Parkinson's Disease.,2023,10.1267/ahc.22-00109,https://pubmed.ncbi.nlm.nih.gov/37124956/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,39286182,Transcriptome and proteomic analysis reveal the protective mechanism of acupuncture on reproductive function in mice with asthenospermia.,2024,10.1016/j.heliyon.2024.e36664,https://pubmed.ncbi.nlm.nih.gov/39286182/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,42792098,Calycosin Safeguards Mitochondrial Genomic Stability and Iron Homeostasis via the NRF2/NRF1-TFAM Axis to Mitigate Doxorubicin-Induced Cardiotoxicity.,2026,10.3390/antiox15091058,https://pubmed.ncbi.nlm.nih.gov/42792098/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,42384160,Bidirectional mendelian randomization identifies plasma proteins associated with cervical cancer risk.,2026,10.1186/s43046-026-00374-7,https://pubmed.ncbi.nlm.nih.gov/42384160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,41603270,Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction.,2026,10.1002/advs.202523583,https://pubmed.ncbi.nlm.nih.gov/41603270/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,39307749,[Mechanism of ligustilide in attenuating OGD/R-induced HT22 cell injury based on FtMt inhibition of ferroptosis].,2024,10.19540/j.cnki.cjcmm.20240412.704,https://pubmed.ncbi.nlm.nih.gov/39307749/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,40393986,Human mitochondrial ferritin exhibits highly unusual iron-O&lt;sub&gt;2&lt;/sub&gt; chemistry distinct from that of cytosolic ferritins.,2025,10.1038/s41467-025-59463-1,https://pubmed.ncbi.nlm.nih.gov/40393986/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,42487586,Naotaifang Formula Suppresses Ferroptosis by Ameliorating Mitochondrial Biogenesis Through the Nrf2/TFAM Pathway in Ischemic Stroke.,2026,10.2174/011570159x443328260518223310,https://pubmed.ncbi.nlm.nih.gov/42487586/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,37440196,Newly uncovered biochemical and functional aspects of ferritin.,2023,10.1096/fj.202300918r,https://pubmed.ncbi.nlm.nih.gov/37440196/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,41908943,Computational and Experimental Biology Reveals Dihydroartemisinin's Efficacy Against Steroid-Induced Osteonecrosis of the Femoral Head Adjusting Ferroptosis via CCL17-PRDX6.,2026,10.2147/dddt.s574294,https://pubmed.ncbi.nlm.nih.gov/41908943/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,39506934,SS-31 modification alleviates ferroptosis induced by superparamagnetic iron oxide nanoparticles in hypoxia/reoxygenation cardiomyocytes.,2024,10.1016/j.heliyon.2024.e38584,https://pubmed.ncbi.nlm.nih.gov/39506934/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,39875498,Mendelian randomization analysis of plasma proteins reveals potential novel tumor markers for gastric cancer.,2025,10.1038/s41598-025-88118-w,https://pubmed.ncbi.nlm.nih.gov/39875498/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,33953171,Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis.,2021,10.1038/s41419-021-03725-5,https://pubmed.ncbi.nlm.nih.gov/33953171/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,32455741,Effects of FTMT Expression by Retinal Pigment Epithelial Cells on Features of Angiogenesis.,2020,10.3390/ijms21103635,https://pubmed.ncbi.nlm.nih.gov/32455741/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,37726294,Oxidative stress induces mitochondrial iron overload and ferroptotic cell death.,2023,10.1038/s41598-023-42760-4,https://pubmed.ncbi.nlm.nih.gov/37726294/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,38388728,Cold-inducible RNA binding protein alleviates iron overload-induced neural ferroptosis under perinatal hypoxia insult.,2024,10.1038/s41418-024-01265-x,https://pubmed.ncbi.nlm.nih.gov/38388728/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTMT,ENSG00000181867,CTA,11323407,A human mitochondrial ferritin encoded by an intronless gene.,2001,10.1074/jbc.c100141200,https://pubmed.ncbi.nlm.nih.gov/11323407/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,38450186,Humoral immunoprofiling identifies novel biomarkers and an immune suppressive autoantibody phenotype at the site of disease in pancreatic ductal adenocarcinoma.,2024,10.3389/fonc.2024.1330419,https://pubmed.ncbi.nlm.nih.gov/38450186/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,32799221,[Regulation of Gene Expression of Cancer/Testis Antigens in Colorectal Cancer Patients].,2020,10.31857/s0026898420040096,https://pubmed.ncbi.nlm.nih.gov/32799221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,33290900,Biological features of tissue and bone sarcomas investigated using an in vitro model of clonal selection.,2021,10.1016/j.prp.2020.153214,https://pubmed.ncbi.nlm.nih.gov/33290900/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,30297572,Cancer-testis antigen GAGE-1 expression and serum immunoreactivity in hepatocellular carcinoma.,2018,10.4103/njcp.njcp_73_18,https://pubmed.ncbi.nlm.nih.gov/30297572/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,31607938,Propagation of Spermatogonial Stem Cell-Like Cells From Infant Boys.,2019,10.3389/fphys.2019.01155,https://pubmed.ncbi.nlm.nih.gov/31607938/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,29577858,Expression and Prognostic Relevance of GAGE1 and XAGE1 Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma.,2017,10.2174/1566524018666180322162145,https://pubmed.ncbi.nlm.nih.gov/29577858/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,30006881,Specific Features of Transcription Activity of Cancer-Testis Antigens in Patients with Metastatic and Non-Metastatic Breast Cancer.,2018,10.1007/s10517-018-4175-x,https://pubmed.ncbi.nlm.nih.gov/30006881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,30103946,Upregulated circular RNA circ_0016760 indicates unfavorable prognosis in NSCLC and promotes cell progression through miR-1287/GAGE1 axis.,2018,10.1016/j.bbrc.2018.07.164,https://pubmed.ncbi.nlm.nih.gov/30103946/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,38561281,[Investigation of the immune profile of multiple myeloma patients achieving long-term survival after autologous stem cell transplantation].,2024,10.3760/cma.j.cn112138-20230906-00112,https://pubmed.ncbi.nlm.nih.gov/38561281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,38200408,Identification of CD8+ T-cell exhaustion signatures for prognosis in HBV-related hepatocellular carcinoma patients by integrated analysis of single-cell and bulk RNA-sequencing.,2024,10.1186/s12885-023-11804-3,https://pubmed.ncbi.nlm.nih.gov/38200408/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,24232866,Cancer testis antigen expression in testicular germ cell tumorigenesis.,2014,10.1038/modpathol.2013.183,https://pubmed.ncbi.nlm.nih.gov/24232866/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,26885621,Novel potential serological prostate cancer biomarkers using CT100+ cancer antigen microarray platform in a multi-cultural South African cohort.,2016,10.18632/oncotarget.7359,https://pubmed.ncbi.nlm.nih.gov/26885621/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,25171478,Survey of autoantibody responses against tumor-associated antigens in thyroid cancer.,2014,10.3233/cbm-140413,https://pubmed.ncbi.nlm.nih.gov/25171478/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,26298164,Pulmonary Metastases Exhibit Epigenetic Clonality: Implications for Precision Cancer Therapy.,2015,10.1016/j.athoracsur.2015.05.089,https://pubmed.ncbi.nlm.nih.gov/26298164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,23574628,"Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene.",2013,10.1111/tan.12113,https://pubmed.ncbi.nlm.nih.gov/23574628/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,23156676,[Early detection of cancer/testis mRNAs in tumor cells circulating in the peripheral blood of colorectal cancer patients].,2012,10.1134/s0026893312050093,https://pubmed.ncbi.nlm.nih.gov/23156676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,23138873,"Immunomodulatory activity of SGI-110, a 5-aza-2'-deoxycytidine-containing demethylating dinucleotide.",2013,10.1007/s00262-012-1365-7,https://pubmed.ncbi.nlm.nih.gov/23138873/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,16929165,Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma.,2006,10.4161/cbt.5.9.3174,https://pubmed.ncbi.nlm.nih.gov/16929165/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,20423514,"Expression of tumor-specific antigen MAGE, GAGE and BAGE in ovarian cancer tissues and cell lines.",2010,10.1186/1471-2407-10-163,https://pubmed.ncbi.nlm.nih.gov/20423514/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,20053773,Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells.,2010,10.1158/1535-7163.mct-09-0486,https://pubmed.ncbi.nlm.nih.gov/20053773/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,12681058,"[Expression of MAGE, GAGE, and BAGE genes in human hepatocellular carcinoma].",2003,,https://pubmed.ncbi.nlm.nih.gov/12681058/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,14607688,"Expression of A, G and B melanoma antigen genes in human hepatocellular carcinoma.",2002,,https://pubmed.ncbi.nlm.nih.gov/14607688/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,10928100,"Relationship between GAGE-1/-2 expression, EBV infection and interferon-gamma expression in undifferentiated carcinoma of nasopharyngeal type.",2000,,https://pubmed.ncbi.nlm.nih.gov/10928100/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,10782910,"Expression of MAGE, GAGE and BAGE genes in human liver diseases: utility as molecular markers for hepatocellular carcinoma.",2000,10.1016/s0168-8278(00)80223-8,https://pubmed.ncbi.nlm.nih.gov/10782910/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,12574209,Analysis of cancer/testis antigens in sporadic medullary thyroid carcinoma: expression and humoral response to NY-ESO-1.,2003,10.1210/jc.2002-020830,https://pubmed.ncbi.nlm.nih.gov/12574209/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,12123095,Expression spectrum and methylation-dependent regulation of melanoma antigen-encoding gene family members in pancreatic cancer cells.,2002,10.1159/000055905,https://pubmed.ncbi.nlm.nih.gov/12123095/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,15201976,Prognostic significance of cancer-testis gene expression in resected non-small cell lung cancer patients.,2004,10.3892/or.12.1.145,https://pubmed.ncbi.nlm.nih.gov/15201976/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,20715104,Pattern and clinical significance of cancer-testis gene expression in head and neck squamous cell carcinoma.,2011,10.1002/ijc.25607,https://pubmed.ncbi.nlm.nih.gov/20715104/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,11953832,Cancer testis antigens expression in mesothelioma: role of DNA methylation and bioimmunotherapeutic implications.,2002,10.1038/sj.bjc.6600174,https://pubmed.ncbi.nlm.nih.gov/11953832/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE1,ENSG00000205777,CTA,7544395,A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.,1995,10.1084/jem.182.3.689,https://pubmed.ncbi.nlm.nih.gov/7544395/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE12E,ENSG00000216649,CTA,37106775,Electrostatic Complementarities of Glioblastoma-Resident T-Cell Receptors and Cancer Testis Antigens Linked to Poor Outcomes and High Levels of Sphingosine Kinase-2 Expression.,2023,10.3390/biology12040575,https://pubmed.ncbi.nlm.nih.gov/37106775/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE12H,ENSG00000224902,CTA,35845819,Comparative Response of HCC Cells to TKIs: Modified in vitro Testing and Descriptive Expression Analysis.,2022,10.2147/jhc.s356333,https://pubmed.ncbi.nlm.nih.gov/35845819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE13,ENSG00000274274,CTA,38217083,An integrative analysis of GEO data to identify possible therapeutic biomarkers of prostate cancer and targeting potential protein through &lt;i&gt;Zea mays&lt;/i&gt; phytochemicals by virtual screening approaches.,2025,10.1080/07391102.2023.2283163,https://pubmed.ncbi.nlm.nih.gov/38217083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE2A,ENSG00000189064,CTA,37835834,Characterization of Cancer/Testis Antigens as Prognostic Markers of Ovarian Cancer.,2023,10.3390/diagnostics13193092,https://pubmed.ncbi.nlm.nih.gov/37835834/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE2A,ENSG00000189064,CTA,41091706,"A survey of human cancer-germline genes: Linking X chromosome localization, DNA methylation and sex-biased expression in early embryos.",2025,10.1371/journal.pgen.1011734,https://pubmed.ncbi.nlm.nih.gov/41091706/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE2A,ENSG00000189064,CTA,42169880,Prognostic genes in hepatocellular carcinoma and their function: an analysis integrating high-throughput-based spatial transcriptomics and single-cell RNA-sequencing.,2026,10.21037/jgo-2026-1-0014,https://pubmed.ncbi.nlm.nih.gov/42169880/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE2A,ENSG00000189064,CTA,37256926,Single-Cell Evolutionary Analysis Reveals Drivers of Plasticity and Mediators of Chemoresistance in Small Cell Lung Cancer.,2023,10.1158/1541-7786.mcr-22-0881,https://pubmed.ncbi.nlm.nih.gov/37256926/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE2A,ENSG00000189064,CTA,38217083,An integrative analysis of GEO data to identify possible therapeutic biomarkers of prostate cancer and targeting potential protein through &lt;i&gt;Zea mays&lt;/i&gt; phytochemicals by virtual screening approaches.,2025,10.1080/07391102.2023.2283163,https://pubmed.ncbi.nlm.nih.gov/38217083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE2A,ENSG00000189064,CTA,35651938,Identification of Novel Characteristics in TP53-Mutant Hepatocellular Carcinoma Using Bioinformatics.,2022,10.3389/fgene.2022.874805,https://pubmed.ncbi.nlm.nih.gov/35651938/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE2A,ENSG00000189064,CTA,32990583,Exploring Potential Proteomic Biomarkers for Prognosis of Infective Endocarditis through Profiled Autoantibodies by an Immunomics Protein Array Technique.,2020,10.1532/hsf.3017,https://pubmed.ncbi.nlm.nih.gov/32990583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE2A,ENSG00000189064,CTA,33004423,Identification of potential crucial genes associated with the pathogenesis and prognosis of liver hepatocellular carcinoma.,2021,10.1136/jclinpath-2020-206979,https://pubmed.ncbi.nlm.nih.gov/33004423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN1B,ENSG00000135248,CTA,38935810,Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads.,2024,10.1371/journal.pgen.1011337,https://pubmed.ncbi.nlm.nih.gov/38935810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN1B,ENSG00000135248,CTA,34714330,FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice.,2021,10.1242/dev.199644,https://pubmed.ncbi.nlm.nih.gov/34714330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN1B,ENSG00000135248,CTA,39194536,Hypoxia-Induced Adaptations of Embryonic Fibroblasts: Implications for Developmental Processes.,2024,10.3390/biology13080598,https://pubmed.ncbi.nlm.nih.gov/39194536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN1B,ENSG00000135248,CTA,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN1B,ENSG00000135248,CTA,34178030,Whole-Exome Sequencing Analysis of Human Semen Quality in Russian Multiethnic Population.,2021,10.3389/fgene.2021.662846,https://pubmed.ncbi.nlm.nih.gov/34178030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN1B,ENSG00000135248,CTA,35220962,Construction and validation of a novel prognostic model for lung squamous cell cancer based on N6-methyladenosine-related genes.,2022,10.1186/s12957-022-02509-1,https://pubmed.ncbi.nlm.nih.gov/35220962/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN1B,ENSG00000135248,CTA,35133054,Downregulation of miR-26 promotes invasion and metastasis via targeting interleukin-22 in cutaneous T-cell lymphoma.,2022,10.1111/cas.15296,https://pubmed.ncbi.nlm.nih.gov/35133054/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN1B,ENSG00000135248,CTA,24012201,Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis.,2013,10.1016/j.fertnstert.2013.07.1999,https://pubmed.ncbi.nlm.nih.gov/24012201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN2,ENSG00000172717,CTA,38935810,Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads.,2024,10.1371/journal.pgen.1011337,https://pubmed.ncbi.nlm.nih.gov/38935810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN2,ENSG00000172717,CTA,37992210,FAM71D is dispensable for spermatogenesis and male fertility in mice.,2023,10.1002/mrd.23716,https://pubmed.ncbi.nlm.nih.gov/37992210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN2,ENSG00000172717,CTA,38489045,Deleterious variant in FAM71D cause male infertility with asthenoteratospermia.,2024,10.1007/s00438-024-02117-6,https://pubmed.ncbi.nlm.nih.gov/38489045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN2,ENSG00000172717,CTA,29025071,The expression characteristics of FAM71D and its association with sperm motility.,2017,10.1093/humrep/dex290,https://pubmed.ncbi.nlm.nih.gov/29025071/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN2,ENSG00000172717,CTA,32054438,"Population-specific, recent positive directional selection suggests adaptation of human male reproductive genes to different environmental conditions.",2020,10.1186/s12862-019-1575-0,https://pubmed.ncbi.nlm.nih.gov/32054438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN2,ENSG00000172717,CTA,24488012,Next-generation sequencing reveals novel rare fusion events with functional implication in prostate cancer.,2015,10.1038/onc.2013.591,https://pubmed.ncbi.nlm.nih.gov/24488012/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN3,ENSG00000170613,CTA,42149173,Garin3 regulates sperm-oocyte fusion and male fertility.,2026,10.1007/s00018-026-06225-x,https://pubmed.ncbi.nlm.nih.gov/42149173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN3,ENSG00000170613,CTA,38935810,Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads.,2024,10.1371/journal.pgen.1011337,https://pubmed.ncbi.nlm.nih.gov/38935810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN3,ENSG00000170613,CTA,25609838,Combining RNA and protein profiling data with network interactions identifies genes associated with spermatogenesis in mouse and human.,2015,10.1095/biolreprod.114.126250,https://pubmed.ncbi.nlm.nih.gov/25609838/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN5B,ENSG00000180043,CTA,38935810,Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads.,2024,10.1371/journal.pgen.1011337,https://pubmed.ncbi.nlm.nih.gov/38935810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN5B,ENSG00000180043,CTA,37990144,Probable human origin of the SARS-CoV-2 polybasic furin cleavage motif.,2023,10.1186/s12863-023-01169-8,https://pubmed.ncbi.nlm.nih.gov/37990144/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN5B,ENSG00000180043,CTA,38293707,Tumour tissue-derived small extracellular vesicles reflect molecular subtypes of bladder cancer.,2024,10.1002/jev2.12402,https://pubmed.ncbi.nlm.nih.gov/38293707/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN5B,ENSG00000180043,CTA,36456645,Development and validation of a novel immune-related prognostic signature in lung squamous cell carcinoma patients.,2022,10.1038/s41598-022-23140-w,https://pubmed.ncbi.nlm.nih.gov/36456645/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,42309824,Cellular and molecular characterization of the testicular development of GDF9-edited pigs.,2026,10.1071/rd26060,https://pubmed.ncbi.nlm.nih.gov/42309824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,42235440,"Genome-wide characterization of the TGF-β superfamily identifies bmp15, gdf9, and gsdf as sex-biased candidate regulators of gonadal differentiation in the synchronous hermaphrodite Plectropomus leopardus.",2026,10.1016/j.cbd.2026.101892,https://pubmed.ncbi.nlm.nih.gov/42235440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,41637829,Comprehensive transcriptome analysis of somatic and gonadal tissues for identification of sex-biased genes in spotted scat (Scatophagus argus).,2026,10.1016/j.cbd.2026.101767,https://pubmed.ncbi.nlm.nih.gov/41637829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,42449921,"GDF9, NPHS1, and RET Mark Gastric Neuroendocrine Cells and Their Disruption in a PKA-Driven Gastric Preneoplasia Model.",2026,10.3390/ijms27135642,https://pubmed.ncbi.nlm.nih.gov/42449921/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,42265580,Differential expression of Musashi 2 in single and double corpus luteum of hybrid Mongolian sheep.,2026,10.1186/s12864-026-12981-8,https://pubmed.ncbi.nlm.nih.gov/42265580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,42059582,"Beware of your ""oocyte specific"" Cre line: somatic cell Cre expression in several Zp3-Cre lines and the Gdf9-iCre transgenic line†.",2026,10.1093/biolre/ioag093,https://pubmed.ncbi.nlm.nih.gov/42059582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,42641285,miR-6388 regulates granulosa cell function in sheep by targeting GDF9 and modulating the TGF-β signaling pathway.,2026,10.1016/j.theriogenology.2026.118154,https://pubmed.ncbi.nlm.nih.gov/42641285/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,41911462,Versatile SMAD2 and SMAD3 epitope-tagged mouse models for genomic profiling of TGFβ signaling: Uncovering GDF9-SMAD2/3 targets.,2026,10.1073/pnas.2600071123,https://pubmed.ncbi.nlm.nih.gov/41911462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,41249776,"Effects of 17α-Ethinylestradiol on Development and Gonadal Differentiation in the Estuarine Mummichog, Fundulus heteroclitus.",2026,10.1002/jez.70045,https://pubmed.ncbi.nlm.nih.gov/41249776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,42046697,Cryoprotectant-dependent preservation of cellular viability and oocyte-secreted factors in slow-frozen feline ovarian tissue.,2026,10.14202/vetworld.2026.1119-1131,https://pubmed.ncbi.nlm.nih.gov/42046697/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,42703805,Innovative Xenotransplantation of Reconstructed Human Artificial Ovary Using 3D-Printed Scaffolds and Umbilical Cord Mesenchymal Stem Cells.,2026,10.22074/ijfs.2025.2056658.1847,https://pubmed.ncbi.nlm.nih.gov/42703805/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,41589036,Co-administration of Bone Marrow-derived Mesenchymal Stem Cells and Royal Jelly Improved Ovarian Tissue Function in PCOS Rats via the Regulation of Inflammation and Angiogenesis.,2026,10.22074/ijfs.2025.2050243.1806,https://pubmed.ncbi.nlm.nih.gov/41589036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,41952612,Growth Differentiation Factor 9 Supplementation Restores the Lipopolysaccharide-Induced Negative Effects on Bovine Oocyte Developmental Competence.,2026,10.1002/mrd.70099,https://pubmed.ncbi.nlm.nih.gov/41952612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,42483667,Ovarian function and X chromosome tissue mosaicism in adolescents with Turner syndrome and ongoing spontaneous puberty.,2026,10.3389/fendo.2026.1866671,https://pubmed.ncbi.nlm.nih.gov/42483667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,42656439,Combination olaparib and cyclophosphamide cancer therapy exacerbates ovarian reserve depletion in mice with conditional loss of &lt;i&gt;Brca1&lt;/i&gt; in oocytes.,2026,10.3389/fendo.2026.1885969,https://pubmed.ncbi.nlm.nih.gov/42656439/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,41673609,AMH specifically targets neuronal AMHR2 to modulate the progression of polycystic ovary syndrome.,2026,10.1186/s12902-025-02130-9,https://pubmed.ncbi.nlm.nih.gov/41673609/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,42008046,Gonadal Transcriptomic Atlas Reveals Conserved and Sex-Biased Regulatory Networks in Black-Spotted Croaker (Protonibea diacanthus).,2026,10.1007/s10126-026-10613-6,https://pubmed.ncbi.nlm.nih.gov/42008046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,40509029,Integrated Analysis of Differential Expression Profiles of miRNA and mRNA in Gonads of &lt;i&gt;Scatophagus argus&lt;/i&gt; Provides New Insights into Sexually Biased Gene Expression.,2025,10.3390/ani15111564,https://pubmed.ncbi.nlm.nih.gov/40509029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,42317645,Genomic characterization of growth differentiation factor 9 (&lt;i&gt;GDF9&lt;/i&gt;): mutational and functional impact on reproductive traits of Cholistani Buchi sheep.,2026,10.1016/j.vas.2026.100728,https://pubmed.ncbi.nlm.nih.gov/42317645/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,41514836,"Comparative RNA-Seq Analysis of Differentially Expressed Genes in the Testis and Ovary of Mudskipper, &lt;i&gt;Boleophthalmus pectinirostris&lt;/i&gt;.",2026,10.3390/ani16010150,https://pubmed.ncbi.nlm.nih.gov/41514836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,42708871,"Peripubertal Exposure to Silver Nanoparticles (AgNPs) Triggers Follicle Activation, Probably Leading to ""Burnout"" by Stimulating the PI3K/AKT/mTOR/AMPK Signaling Pathway.",2026,,https://pubmed.ncbi.nlm.nih.gov/42708871/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,42289696,"Stage-, dose- and course-dependent disruption of mice fetal ovarian development following prenatal dexamethasone exposure.",2026,10.1186/s13048-026-02158-y,https://pubmed.ncbi.nlm.nih.gov/42289696/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,42089299,Potential Effects of Prepubertal Exposure to Perfluorooctane Sulfonic Acid on the First Wave of Folliculogenesis in Young CD-1 Mice.,2026,10.1002/bdr2.70052,https://pubmed.ncbi.nlm.nih.gov/42089299/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,39293100,Novel Insight into the mechanism of di (2-ethylhexyl) phthalate (DEHP) impairing early follicle development.,2024,10.1016/j.ecoenv.2024.117043,https://pubmed.ncbi.nlm.nih.gov/39293100/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,40615883,"The effect of aqueous Stevia rebaudiana extract and clomiphene citrate on the expression of GDF9, PTEN, BMP15 genes, and antioxidant levels in a letrozole-induced polycystic ovary syndrome model in Wistar rats.",2025,10.1186/s13048-025-01719-x,https://pubmed.ncbi.nlm.nih.gov/40615883/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,40261459,Regulating human oocyte maturation in vitro: a hypothesis based on oocytes retrieved from small antral follicles during ovarian tissue cryopreservation.,2025,10.1007/s10815-025-03483-9,https://pubmed.ncbi.nlm.nih.gov/40261459/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,40723388,Urolithin A Protects Ovarian Reserve Via Inhibiting PI3K/Akt Signaling and Preventing Chemotherapy-Induced Follicle Apoptosis.,2025,10.3390/biology14070829,https://pubmed.ncbi.nlm.nih.gov/40723388/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,39343644,Growth differentiation factor 9 activates the TGF-β pathway in follicle atresia of Muscovy ducks.,2024,10.1016/j.psj.2024.104278,https://pubmed.ncbi.nlm.nih.gov/39343644/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,40153751,Comprehensive analysis of GDFs as therapeutic targets and prognosis biomarkers in gastric cancer.,2025,10.1097/md.0000000000041976,https://pubmed.ncbi.nlm.nih.gov/40153751/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,39922201,Impact of female age on concentrations of reproductive hormones and oocyte-specific growth factors in follicular fluid from human small antral follicles.,2025,10.1093/humrep/deaf017,https://pubmed.ncbi.nlm.nih.gov/39922201/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,40969411,Thymoquinone alleviates the adverse effects of cyclophosphamide on oogenesis and in vitro fertilization (IVF) in NMRI mice.,2025,10.22038/ajp.2025.25734,https://pubmed.ncbi.nlm.nih.gov/40969411/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,42883097,"Balancing Prolificacy and Lamb Meat Production: Links Among Litter Size, Prenatal Development, Carcass Traits, and Meat Quality in Sheep.",2026,10.3390/ani16193128,https://pubmed.ncbi.nlm.nih.gov/42883097/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,41216763,Disruption of ovarian function and induction of apoptosis in female mice by Brefeldin A: Mechanistic insights into reproductive toxicity.,2025,10.1002/ame2.70102,https://pubmed.ncbi.nlm.nih.gov/41216763/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,41304892,Fluoxetine Disrupts Ovarian Serotonin Signaling and Oocyte Competence in Mice.,2025,10.3390/ph18111647,https://pubmed.ncbi.nlm.nih.gov/41304892/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,39730946,Hepatitis B virus impacts embryonic development and methylation of maternal genes in assisted reproductive technology patients.,2025,10.1007/s10815-024-03359-4,https://pubmed.ncbi.nlm.nih.gov/39730946/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,42260579,Developmental and functional landscape of theca cells in ovarian biology.,2026,10.1186/s40659-026-00680-3,https://pubmed.ncbi.nlm.nih.gov/42260579/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,12050262,Growth differentiation factor-9 inhibits 3'5'-adenosine monophosphate-stimulated steroidogenesis in human granulosa and theca cells.,2002,10.1210/jcem.87.6.8551,https://pubmed.ncbi.nlm.nih.gov/12050262/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF9,ENSG00000164404,CTA,10443672,Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis.,1999,10.1210/jcem.84.8.5921,https://pubmed.ncbi.nlm.nih.gov/10443672/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLIPR1L1,ENSG00000173401,CTA,40572022,Mouse genome engineering uncovers 18 genes dispensable for male reproduction.,2026,10.1111/andr.70088,https://pubmed.ncbi.nlm.nih.gov/40572022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLIPR1L1,ENSG00000173401,CTA,31672133,GLIPR1L1 is an IZUMO-binding protein required for optimal fertilization in the mouse.,2019,10.1186/s12915-019-0701-1,https://pubmed.ncbi.nlm.nih.gov/31672133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLIPR1L1,ENSG00000173401,CTA,22552861,Bovine sperm raft membrane associated Glioma Pathogenesis-Related 1-like protein 1 (GliPr1L1) is modified during the epididymal transit and is potentially involved in sperm binding to the zona pellucida.,2012,10.1002/jcp.24099,https://pubmed.ncbi.nlm.nih.gov/22552861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLIPR1L1,ENSG00000173401,CTA,20219979,"Glioma pathogenesis-related 1-like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte binding.",2010,10.1210/en.2009-1255,https://pubmed.ncbi.nlm.nih.gov/20219979/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLIPR1L1,ENSG00000173401,CTA,16714093,"Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster.",2006,10.1016/j.ygeno.2006.03.021,https://pubmed.ncbi.nlm.nih.gov/16714093/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLIPR1L1,ENSG00000173401,CTA,23785420,CD9-positive microvesicles mediate the transfer of molecules to Bovine Spermatozoa during epididymal maturation.,2013,10.1371/journal.pone.0065364,https://pubmed.ncbi.nlm.nih.gov/23785420/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLIPR1L1,ENSG00000173401,CTA,23583282,Detailed genome-wide SNP analysis of major salivary carcinomas localizes subtype-specific chromosome sites and oncogenes of potential clinical significance.,2013,10.1016/j.ajpath.2013.02.020,https://pubmed.ncbi.nlm.nih.gov/23583282/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOLGA6A,ENSG00000159289,CTA,35551164,Transcriptomic Profiling Revealed Lnc-GOLGA6A-1 as a Novel Prognostic Biomarker of Meningioma Recurrence.,2022,10.1227/neu.0000000000002026,https://pubmed.ncbi.nlm.nih.gov/35551164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOLGA6A,ENSG00000159289,CTA,33126901,Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility.,2020,10.1186/s12958-020-00660-6,https://pubmed.ncbi.nlm.nih.gov/33126901/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOLGA6A,ENSG00000159289,CTA,35845819,Comparative Response of HCC Cells to TKIs: Modified in vitro Testing and Descriptive Expression Analysis.,2022,10.2147/jhc.s356333,https://pubmed.ncbi.nlm.nih.gov/35845819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOLGA6A,ENSG00000159289,CTA,20160164,Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study.,2010,10.1182/blood-2009-07-234229,https://pubmed.ncbi.nlm.nih.gov/20160164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOLGA6C,ENSG00000167195,CTA,37372085,Towards a More Comprehensive Picture of the MicroRNA-23a/b-3p Impact on Impaired Male Fertility.,2023,10.3390/biology12060800,https://pubmed.ncbi.nlm.nih.gov/37372085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOLGA6C,ENSG00000167195,CTA,35880269,NLRC5 Might Promote Endometrial Cancer Progression by Inducing PD-L1 Expression.,2022,10.1177/15330338221112742,https://pubmed.ncbi.nlm.nih.gov/35880269/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOLGA6L2,ENSG00000174450,CTA,36289533,DUSP5 and PHLDA1 mutations in mature cystic teratomas of the ovary identified on whole-exome sequencing may explain teratoma characteristics.,2022,10.1186/s40246-022-00424-w,https://pubmed.ncbi.nlm.nih.gov/36289533/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOLGA6L2,ENSG00000174450,CTA,35574418,Tumor Suppressive Role of MUC6 in Wilms Tumor via Autophagy-Dependent β-Catenin Degradation.,2022,10.3389/fonc.2022.756117,https://pubmed.ncbi.nlm.nih.gov/35574418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOLGA6L2,ENSG00000174450,CTA,32493417,Fusions involving BCOR and CREBBP are rare events in infiltrating glioma.,2020,10.1186/s40478-020-00951-4,https://pubmed.ncbi.nlm.nih.gov/32493417/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOLGA6L2,ENSG00000174450,CTA,32461543,Whole Exome Sequencing of Multiple Atypical Meningiomas in a Patient without History of Neurofibromatosis Type II: A Case Report.,2020,10.12659/ajcr.923928,https://pubmed.ncbi.nlm.nih.gov/32461543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOLGA6L2,ENSG00000174450,CTA,23124039,Angelman syndrome and severe infections in a patient with de novo 15q11.2-q13.1 deletion and maternally inherited 2q21.3 microdeletion.,2013,10.1016/j.gene.2012.10.061,https://pubmed.ncbi.nlm.nih.gov/23124039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOLGA8G,ENSG00000183629,CTA,21309479,ADP-ribosylation factor guanine nucleotide-exchange factor 2 (ARFGEF2): a new potential biomarker in Huntington's disease.,2010,10.1177/147323001003800510,https://pubmed.ncbi.nlm.nih.gov/21309479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,42391677,Interaction of ARA54 with androgen receptor in mediating testosterone-dependent regulation of caput epididymal GPX5 expression in mice.,2026,10.1016/j.theriogenology.2026.118055,https://pubmed.ncbi.nlm.nih.gov/42391677/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,40806354,Antioxidant Enzyme Activity and mRNA Expression in the Reproductive Tissues of Male European Red Deer (&lt;i&gt;Cervus elaphus elaphus&lt;/i&gt;).,2025,10.3390/ijms26157221,https://pubmed.ncbi.nlm.nih.gov/40806354/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,41482640,Yttrium Nitrate Exacerbates Oxidative Stress in the Mouse Epididymis by Inhibiting GPX5 Expression.,2026,10.1002/jat.70055,https://pubmed.ncbi.nlm.nih.gov/41482640/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,42664731,"Genome-wide identification, characterization, and expression analysis of the glutathione peroxidase (GPX) gene family in Siniperca chuatsi.",2026,10.1016/j.cbd.2026.101981,https://pubmed.ncbi.nlm.nih.gov/42664731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,42641857,Polypropylene microplastics orchestrate oxidative stress microenvironment and trigger metabolic reprogramming in mouse kidney as revealed by Raman spectra and metabolomics.,2026,10.1016/j.envpol.2026.129000,https://pubmed.ncbi.nlm.nih.gov/42641857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,39408895,GPX5-Enriched Exosomes Improve Sperm Quality and Fertilization Ability.,2024,10.3390/ijms251910569,https://pubmed.ncbi.nlm.nih.gov/39408895/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,41375333,Impact of &lt;i&gt;Ficus deltoidea&lt;/i&gt; Aqueous Extract on Maternal Hepatic Drug Metabolism and Foetal Development in Rats.,2025,10.3390/plants14233623,https://pubmed.ncbi.nlm.nih.gov/41375333/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,37290785,Differential expression and localisation of heat shock protein 70 (HSP70) and glutathione peroxidase 5 (GPX5) in the testis and epididymis of Sonid Bactrian camels.,2023,10.1071/rd23026,https://pubmed.ncbi.nlm.nih.gov/37290785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,39951496,Melatonin modulated GPX5 and PTGDS expression in Bactrian camel epididymis mainly via receptor MT1†.,2025,10.1093/biolre/ioaf030,https://pubmed.ncbi.nlm.nih.gov/39951496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,41718785,Expression patterns of glutathione peroxidases family members during tooth development.,2026,10.1007/s10735-026-10748-9,https://pubmed.ncbi.nlm.nih.gov/41718785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,38666419,Exploring novel function of Gpx5 antioxidant activity: Assisting epididymal cells secrete functional extracellular vesicles.,2024,10.1002/jcp.31273,https://pubmed.ncbi.nlm.nih.gov/38666419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,38787121,The Male Reproductive Toxicity Caused by 2-Naphthylamine Was Related to Testicular Immunity Disorders.,2024,10.3390/toxics12050342,https://pubmed.ncbi.nlm.nih.gov/38787121/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,41007268,Comprehensive Physiological and Transcriptomic Profiling of Triploid Pacific Oysters (&lt;i&gt;Crassostrea gigas&lt;/i&gt;) Under Ammonia Exposure.,2025,10.3390/biology14091121,https://pubmed.ncbi.nlm.nih.gov/41007268/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,37761814,Glutathione Peroxidase gpx1 to gpx8 Genes Expression in Experimental Brain Tumors Reveals Gender-Dependent Patterns.,2023,10.3390/genes14091674,https://pubmed.ncbi.nlm.nih.gov/37761814/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,42375264,Proteomic profile of seminal plasma in tropical Saanen bucks under heat stress using 1D-SDS PAGE.,2026,10.5455/ovj.2026.v16.i1.32,https://pubmed.ncbi.nlm.nih.gov/42375264/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,38145478,Abundance of selected genes implicated in testicular functions in Camelus dromedarius with high and low epididymal semen quality.,2024,10.1093/biolre/ioad177,https://pubmed.ncbi.nlm.nih.gov/38145478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,41299134,OsNTL2 confers rice osmotic stress resilience through coordinated transcriptional regulation of the ASC-GSH redox cycle and cell wall biosynthesis.,2025,10.1007/s44154-025-00271-4,https://pubmed.ncbi.nlm.nih.gov/41299134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,36937839,Research progress of glutathione peroxidase family (GPX) in redoxidation.,2023,10.3389/fphar.2023.1147414,https://pubmed.ncbi.nlm.nih.gov/36937839/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,38615983,Overexpression of Rhodiola crenulata glutathione peroxidase 5 increases cold tolerance and enhances the pharmaceutical value of the hairy roots.,2024,10.1016/j.gene.2024.148467,https://pubmed.ncbi.nlm.nih.gov/38615983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,32270769,Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice.,2020,10.4103/aja.aja_3_20,https://pubmed.ncbi.nlm.nih.gov/32270769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,38892012,"Development of a Normal Porcine Cell Line Growing in a Heme-Supplemented, Serum-Free Condition for Cultured Meat.",2024,10.3390/ijms25115824,https://pubmed.ncbi.nlm.nih.gov/38892012/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,38796044,Rosmarinic acid mitigates intestinal inflammation and oxidative stress in bullfrogs (Lithobates catesbeiana) fed high soybean meal diets.,2024,10.1016/j.fsi.2024.109655,https://pubmed.ncbi.nlm.nih.gov/38796044/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,36860060,Translatomics and physiological analyses of the detoxification mechanism of green alga Chlamydomonas reinhardtii to cadmium toxicity.,2023,10.1016/j.jhazmat.2023.130990,https://pubmed.ncbi.nlm.nih.gov/36860060/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,38393890,The prognostic and antitumor roles of key genes of ferroptosis in liver hepatocellular cancer and stomach adenocarcinoma.,2024,10.3233/cbm-230114,https://pubmed.ncbi.nlm.nih.gov/38393890/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,37269507,Alleviation of cadmium-induced photoinhibition and oxidative stress by melatonin in Chlamydomonas reinhardtii.,2023,10.1007/s11356-023-27561-6,https://pubmed.ncbi.nlm.nih.gov/37269507/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,31692026,Anticancer properties of green-synthesised zinc oxide nanoparticles using Hyssopus officinalis extract on prostate carcinoma cells and its effects on testicular damage and spermatogenesis in Balb/C mice.,2020,10.1111/and.13450,https://pubmed.ncbi.nlm.nih.gov/31692026/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,36138806,Genetic Diversity and Selective Signature in Dabieshan Cattle Revealed by Whole-Genome Resequencing.,2022,10.3390/biology11091327,https://pubmed.ncbi.nlm.nih.gov/36138806/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,33297066,Effects of cypermethrin on the hepatic transcriptome and proteome of the red claw crayfish Cherax quadricarinatus.,2021,10.1016/j.chemosphere.2020.128060,https://pubmed.ncbi.nlm.nih.gov/33297066/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,35131677,Antioxidant properties and transcriptome of cauda epididymis with different levels of fertility in Hu lambs.,2022,10.1016/j.theriogenology.2022.01.035,https://pubmed.ncbi.nlm.nih.gov/35131677/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,35143416,A web-based calculator for predicting the prognosis of patients with sarcoma on the basis of antioxidant gene signatures.,2022,10.18632/aging.203885,https://pubmed.ncbi.nlm.nih.gov/35143416/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,33133596,Potential relationship between the selenoproteome and cancer.,2020,10.3892/mco.2020.2153,https://pubmed.ncbi.nlm.nih.gov/33133596/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,27025717,Copper-Induced Spermatozoa Head Malformation Is Related to Oxidative Damage to Testes in CD-1 Mice.,2016,10.1007/s12011-016-0675-6,https://pubmed.ncbi.nlm.nih.gov/27025717/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,31981954,Whole-genome re-sequencing and transcriptome reveal cadmium tolerance related genes and pathways in Chlamydomonas reinhardtii.,2020,10.1016/j.ecoenv.2020.110231,https://pubmed.ncbi.nlm.nih.gov/31981954/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,28011267,Methotrexate-induced germ cell toxicity and the important role of zinc and SOD1: Investigation of molecular mechanisms.,2017,10.1016/j.bbrc.2016.12.098,https://pubmed.ncbi.nlm.nih.gov/28011267/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX5,ENSG00000224586,CTA,22719900,Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice.,2012,10.1371/journal.pone.0038565,https://pubmed.ncbi.nlm.nih.gov/22719900/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AB1,ENSG00000274183,CTA,42462501,Protective effect of soybean isoflavone (SI) on ovarian damages by zinc oxide nanoparticles (ZnONPs) in female mice.,2026,10.1016/j.jtemb.2026.127926,https://pubmed.ncbi.nlm.nih.gov/42462501/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AB1,ENSG00000274183,CTA,42554183,Wnt signalling pathway dysfunction in non-obstructive azoospermia: identifying key genes and potential therapeutic targets.,2026,10.1017/s0967199426100549,https://pubmed.ncbi.nlm.nih.gov/42554183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AB1,ENSG00000274183,CTA,30850480,"Loss of Antigen Presentation in Adipose Tissue Macrophages or in Adipocytes, but Not Both, Improves Glucose Metabolism.",2019,10.4049/jimmunol.1801470,https://pubmed.ncbi.nlm.nih.gov/30850480/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AB1,ENSG00000274183,CTA,20188161,"TSEG-1, a novel member of histone H2A variants, participates in spermatogenesis via promoting apoptosis of spermatogenic cells.",2010,10.1016/j.ygeno.2010.02.005,https://pubmed.ncbi.nlm.nih.gov/20188161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AB1,ENSG00000274183,CTA,20008104,H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis.,2010,10.1093/nar/gkp1129,https://pubmed.ncbi.nlm.nih.gov/20008104/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AP,ENSG00000187516,CTA,35774851,Identification of Five N6-Methylandenosine-Related ncRNA Signatures to Predict the Overall Survival of Patients with Gastric Cancer.,2022,10.1155/2022/7765900,https://pubmed.ncbi.nlm.nih.gov/35774851/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AP,ENSG00000187516,CTA,30066726,Transcriptomic differential lncRNA expression is involved in neuropathic pain in rat dorsal root ganglion after spared sciatic nerve injury.,2018,10.1590/1414-431x20187113,https://pubmed.ncbi.nlm.nih.gov/30066726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AP,ENSG00000187516,CTA,19656046,Identification of a hydroxyproline transport system in the legume endosymbiont Sinorhizobium meliloti.,2009,10.1094/mpmi-22-9-1116,https://pubmed.ncbi.nlm.nih.gov/19656046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AP,ENSG00000187516,CTA,16345076,The Histone Database: a comprehensive resource for histones and histone fold-containing proteins.,2006,10.1002/prot.20814,https://pubmed.ncbi.nlm.nih.gov/16345076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,42371798,NSD2 degradation remediates the oncogenic cistrome in t(4;14) multiple myeloma.,2026,10.1182/blood.2025031998,https://pubmed.ncbi.nlm.nih.gov/42371798/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,42442058,Discovery and biological evaluation of HS13 as a novel covalent ligand targeting the NSD2-PWWP1 domain.,2026,10.1016/j.bmc.2026.118751,https://pubmed.ncbi.nlm.nih.gov/42442058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,41264880,Fragment-Based Screening of NSD2-PWWP1 Identifies Novel Covalent Allosteric Ligands That Diminish Methyllysine and DNA Binding Abilities of NSD2.,2025,10.1021/acs.jmedchem.5c01902,https://pubmed.ncbi.nlm.nih.gov/41264880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,41108541,Genome-Wide Association Study of Cognitive Function in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study.,2025,10.1111/gbb.70038,https://pubmed.ncbi.nlm.nih.gov/41108541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,41232685,Genome-wide cross-trait analyses reveal shared genetic architecture and causal links between attention-deficit/hyperactivity disorder and cardiovascular diseases.,2026,10.1016/j.jad.2025.120639,https://pubmed.ncbi.nlm.nih.gov/41232685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,39705735,Discovery of SET domain-binding primary alkylamine-tethered degraders for the simultaneous degradation of NSD2-long and RE-IIBP isoforms.,2025,10.1016/j.ejmech.2024.117179,https://pubmed.ncbi.nlm.nih.gov/39705735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,39163297,"Unveiling the potential of phytochemicals to inhibit nuclear receptor binding SET domain protein 2 for cancer: Pharmacophore screening, molecular docking, ADME properties, and molecular dynamics simulation investigations.",2024,10.1371/journal.pone.0308913,https://pubmed.ncbi.nlm.nih.gov/39163297/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,40358473,Three ARID proteins involved in chromatin remodeling PEAT complexes are targeted by the Ralstonia solanacearum effector PopP2 and contribute to bacterial wilt disease.,2025,10.1111/tpj.70205,https://pubmed.ncbi.nlm.nih.gov/40358473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,35704853,Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors.,2022,10.1021/acs.jmedchem.2c00709,https://pubmed.ncbi.nlm.nih.gov/35704853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,34782742,A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.,2022,10.1038/s41589-021-00898-0,https://pubmed.ncbi.nlm.nih.gov/34782742/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,38956246,ESCCPred: a machine learning model for diagnostic prediction of early esophageal squamous cell carcinoma using autoantibody profiles.,2024,10.1038/s41416-024-02781-w,https://pubmed.ncbi.nlm.nih.gov/38956246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,34469831,A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells.,2022,10.1016/j.chembiol.2021.08.004,https://pubmed.ncbi.nlm.nih.gov/34469831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,36550402,NSD1 gene evolves under episodic selection within primates and mutations of specific exons in humans cause Sotos syndrome.,2022,10.1186/s12864-022-09071-w,https://pubmed.ncbi.nlm.nih.gov/36550402/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,37822080,Dual roles of the Arabidopsis PEAT complex in histone H2A deubiquitination and H4K5 acetylation.,2023,10.1016/j.molp.2023.10.006,https://pubmed.ncbi.nlm.nih.gov/37822080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,31285596,Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.,2019,10.1038/s41589-019-0310-x,https://pubmed.ncbi.nlm.nih.gov/31285596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,33522809,Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2.,2021,10.1021/acs.jmedchem.0c01768,https://pubmed.ncbi.nlm.nih.gov/33522809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,34271259,Histone and DNA binding ability studies of the NSD subfamily of PWWP domains.,2021,10.1016/j.bbrc.2021.07.017,https://pubmed.ncbi.nlm.nih.gov/34271259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,36082705,[Prediction of immune-related genes associated with prognosis in patients with hepatocellular carcinoma by bioinformatics methods].,2022,,https://pubmed.ncbi.nlm.nih.gov/36082705/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,30072631,Stem-Like Signature Predicting Disease Progression in Early Stage Bladder Cancer. The Role of E2F3 and SOX4.,2018,10.3390/biomedicines6030085,https://pubmed.ncbi.nlm.nih.gov/30072631/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,29101251,The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3.,2017,10.1084/jem.20170856,https://pubmed.ncbi.nlm.nih.gov/29101251/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HDGFL1,ENSG00000112273,CTA,40959233,Structural and Molecular Insight into the PWWP1 Domain of NSD2 from the Discovery of Novel Binders Via DNA-Encoded Library Screening.,2025,10.1021/acsmedchemlett.5c00396,https://pubmed.ncbi.nlm.nih.gov/40959233/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HHIPL2,ENSG00000143512,CTA,42438600,Identification of immunopeptides (pHLA) as candidate therapeutic targets in chondrosarcoma.,2026,10.1016/j.jbo.2026.100780,https://pubmed.ncbi.nlm.nih.gov/42438600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HHIPL2,ENSG00000143512,CTA,41413056,HHIPL2 positively governs Hedgehog signaling to accelerate non-small cell lung cancer progression via enhancing HNRNPC-mediated HNF1A mRNA stabilization.,2025,10.1038/s41419-025-08331-3,https://pubmed.ncbi.nlm.nih.gov/41413056/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HHIPL2,ENSG00000143512,CTA,42447036,Mitochondrial gene expression-based model for the prediction of thyroid cancer prognosis.,2026,10.1530/ec-26-0245,https://pubmed.ncbi.nlm.nih.gov/42447036/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HHIPL2,ENSG00000143512,CTA,37479755,A novel tumor microenvironment-related gene signature with immune features for prognosis of lung squamous cell carcinoma.,2023,10.1007/s00432-023-05042-0,https://pubmed.ncbi.nlm.nih.gov/37479755/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HHIPL2,ENSG00000143512,CTA,36386800,Identification of genes related to sexual differentiation and sterility in embryonic gonads of Mule ducks by transcriptome analysis.,2022,10.3389/fgene.2022.1037810,https://pubmed.ncbi.nlm.nih.gov/36386800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HHIPL2,ENSG00000143512,CTA,37724140,Transcriptome Data Reveal Geographic Heterogeneity in Gene Expression in Patients with Prostate Cancer.,2023,10.52547/rbmb.12.1.92,https://pubmed.ncbi.nlm.nih.gov/37724140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HHIPL2,ENSG00000143512,CTA,38111060,Risk factors analysis and survival prediction model establishment of patients with lung adenocarcinoma based on different pyroptosis-related gene subtypes.,2023,10.1186/s40001-023-01581-x,https://pubmed.ncbi.nlm.nih.gov/38111060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HHIPL2,ENSG00000143512,CTA,36519025,"Multi-omics consensus portfolio to refine the classification of lung adenocarcinoma with prognostic stratification, tumor microenvironment, and unique sensitivity to first-line therapies.",2022,10.21037/tlcr-22-775,https://pubmed.ncbi.nlm.nih.gov/36519025/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HHIPL2,ENSG00000143512,CTA,16391842,Comparative genomics on HHIP family orthologs.,2006,10.3892/ijmm.17.2.391,https://pubmed.ncbi.nlm.nih.gov/16391842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HHIPL2,ENSG00000143512,CTA,30445766,Transcriptome Analysis of Long Non-Coding RNA in the Bovine Mammary Gland Following Dietary Supplementation with Linseed Oil and Safflower Oil.,2018,10.3390/ijms19113610,https://pubmed.ncbi.nlm.nih.gov/30445766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HHIPL2,ENSG00000143512,CTA,29677633,Differences in the bovine milk whey proteome between early pregnancy and the estrous cycle.,2018,10.1016/j.theriogenology.2018.04.008,https://pubmed.ncbi.nlm.nih.gov/29677633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HHIPL2,ENSG00000143512,CTA,20187983,Genome-wide gene copy number and expression analysis of primary gastric tumors and gastric cancer cell lines.,2010,10.1186/1471-2407-10-73,https://pubmed.ncbi.nlm.nih.gov/20187983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HHIPL2,ENSG00000143512,CTA,29930801,"Identification of nine genes as novel susceptibility loci for early-onset ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage.",2018,10.3892/br.2018.1104,https://pubmed.ncbi.nlm.nih.gov/29930801/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,42493501,SYCP2 recruits HORMAD2 to chromosome axes for unsynapsed chromatin silencing and synapsis surveillance in meiosis.,2026,10.1038/s41467-026-75839-3,https://pubmed.ncbi.nlm.nih.gov/42493501/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,40050306,Aberrant activation of chromosome asynapsis checkpoint triggers oocyte elimination.,2025,10.1038/s41467-025-57702-z,https://pubmed.ncbi.nlm.nih.gov/40050306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,38401263,The N-terminal modification of HORMAD2 causes its ectopic persistence on synapsed chromosomes without meiotic blockade.,2024,10.1530/rep-23-0330,https://pubmed.ncbi.nlm.nih.gov/38401263/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,42059593,"The synaptonemal complex: structure, function, and clinical implications†.",2026,10.1093/biolre/ioag092,https://pubmed.ncbi.nlm.nih.gov/42059593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,41694356,Aberrant signaling in tonsillar B cells producing pathogenic &lt;i&gt;O&lt;/i&gt;-glycoforms of IgA1 in IgA nephropathy.,2026,10.3389/fimmu.2026.1737992,https://pubmed.ncbi.nlm.nih.gov/41694356/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,41372126,Transformer-based deep learning enhances discovery in migraine GWAS.,2025,10.1038/s41467-025-65991-7,https://pubmed.ncbi.nlm.nih.gov/41372126/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,40701953,Genome-wide association study of pulpal and apical diseases.,2025,10.1038/s41467-025-61721-1,https://pubmed.ncbi.nlm.nih.gov/40701953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,40963858,Multi-disease transcriptomic analysis of sex hormone genes reveals a novel prognostic model for thyroid cancer with breast cancer correlations.,2025,10.3389/fonc.2025.1641195,https://pubmed.ncbi.nlm.nih.gov/40963858/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,40635857,"WGCNA combined with machine learning to explore potential biomarkers and treatment strategies for acute liver failure, with experimental validation.",2024,10.1016/j.iliver.2024.100133,https://pubmed.ncbi.nlm.nih.gov/40635857/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,38400599,A homozygous stop codon in HORMAD2 in a patient with recurrent digynic triploid miscarriage.,2024,10.1002/mgg3.2402,https://pubmed.ncbi.nlm.nih.gov/38400599/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,39961811,A simple immunohistochemical method for perinatal mammalian ovaries revealed different kinetics of oocyte apoptosis caused by DNA damage and asynapsis.,2025,10.1007/s00418-025-02358-5,https://pubmed.ncbi.nlm.nih.gov/39961811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,35133274,"Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis.",2022,10.7554/elife.68677,https://pubmed.ncbi.nlm.nih.gov/35133274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,37685869,Mucosal Immune Defence Gene Polymorphisms as Relevant Players in the Pathogenesis of IgA Vasculitis?,2023,10.3390/ijms241713063,https://pubmed.ncbi.nlm.nih.gov/37685869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,30039914,HORMAD2 methylation-mediated epigenetic regulation of gene expression in thyroid cancer.,2018,10.1111/jcmm.13680,https://pubmed.ncbi.nlm.nih.gov/30039914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,35719401,N 6 -Methyladenosine-Related Long Non-Coding RNAs Are Identified as a Potential Prognostic Biomarker for Lung Squamous Cell Carcinoma and Validated by Real-Time PCR.,2022,10.3389/fgene.2022.839957,https://pubmed.ncbi.nlm.nih.gov/35719401/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,37414396,MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy.,2023,10.1016/j.kint.2023.06.018,https://pubmed.ncbi.nlm.nih.gov/37414396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,22893617,"HORMAD2/CT46.2, a novel cancer/testis gene, is ectopically expressed in lung cancer tissues.",2012,10.1093/molehr/gas033,https://pubmed.ncbi.nlm.nih.gov/22893617/,annotation citations | normal,Discussed in explicit gene adjudication; see its review depth and limitations
HORMAD2,ENSG00000176635,CTA,34754221,Identification and Validation of a Seizure-Free-Related Gene Signature for Predicting Poor Prognosis in Lower-Grade Gliomas.,2021,10.2147/ijgm.s329745,https://pubmed.ncbi.nlm.nih.gov/34754221/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,24803422,Genetic study of Hormad1 and Hormad2 with non-obstructive azoospermia patients in the male Chinese population.,2014,10.1007/s10815-014-0244-x,https://pubmed.ncbi.nlm.nih.gov/24803422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,34868980,Identification of a N6-Methyladenosine (m6A)-Related lncRNA Signature for Predicting the Prognosis and Immune Landscape of Lung Squamous Cell Carcinoma.,2021,10.3389/fonc.2021.763027,https://pubmed.ncbi.nlm.nih.gov/34868980/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,31991737,Dynamic Shifts in the HIV Proviral Landscape During Long Term Combination Antiretroviral Therapy: Implications for Persistence and Control of HIV Infections.,2020,10.3390/v12020136,https://pubmed.ncbi.nlm.nih.gov/31991737/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,34090518,The REASON score: an epigenetic and clinicopathologic score to predict risk of poor survival in patients with early stage oral squamous cell carcinoma.,2021,10.1186/s40364-021-00292-x,https://pubmed.ncbi.nlm.nih.gov/34090518/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,32473092,Bi-allelic Missense Pathogenic Variants in TRIP13 Cause Female Infertility Characterized by Oocyte Maturation Arrest.,2020,10.1016/j.ajhg.2020.05.001,https://pubmed.ncbi.nlm.nih.gov/32473092/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,28955037,"Human hepatic gene expression signature of non-alcoholic fatty liver disease progression, a meta-analysis.",2017,10.1038/s41598-017-10930-w,https://pubmed.ncbi.nlm.nih.gov/28955037/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,30333500,The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells.,2018,10.1038/s41598-018-33601-w,https://pubmed.ncbi.nlm.nih.gov/30333500/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,25446517,The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins.,2014,10.1016/j.devcel.2014.09.013,https://pubmed.ncbi.nlm.nih.gov/25446517/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,28506208,A strategy to apply quantitative epistasis analysis on developmental traits.,2017,10.1186/s12863-017-0508-4,https://pubmed.ncbi.nlm.nih.gov/28506208/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,26240347,MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation.,2015,10.1073/pnas.1501752112,https://pubmed.ncbi.nlm.nih.gov/26240347/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,23072577,Pathogenesis of immunoglobulin A nephropathy: recent insight from genetic studies.,2013,10.1146/annurev-med-041811-142014,https://pubmed.ncbi.nlm.nih.gov/23072577/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,22737082,Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis.,2012,10.1371/journal.pgen.1002765,https://pubmed.ncbi.nlm.nih.gov/22737082/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD2,ENSG00000176635,CTA,15999985,"Identification of CT46/HORMAD1, an immunogenic cancer/testis antigen encoding a putative meiosis-related protein.",2005,,https://pubmed.ncbi.nlm.nih.gov/15999985/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX2,ENSG00000268738,CTA,42664599,Discovery of a novel CDK8 inhibitor as dual suppressor of NF-κB-driven inflammation and promoter of Treg differentiation for psoriasis treatment.,2026,10.1016/j.bioorg.2026.110419,https://pubmed.ncbi.nlm.nih.gov/42664599/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX2,ENSG00000268738,CTA,38879345,LW-1 induced resistance to TMV in tobacco was mediated by nitric oxide and salicylic acid pathway.,2024,10.1016/j.pestbp.2024.105896,https://pubmed.ncbi.nlm.nih.gov/38879345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX2,ENSG00000268738,CTA,37928861,Development of a novel hypochlorite ratio probe based on coumarin and its application in living cells.,2023,10.1039/d3ra04729f,https://pubmed.ncbi.nlm.nih.gov/37928861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX2,ENSG00000268738,CTA,35104110,Visualizing the Interplay of Lipid Droplets and Protein Aggregates During Aging via a Dual-Functional Fluorescent Probe.,2022,10.1021/acs.analchem.1c04278,https://pubmed.ncbi.nlm.nih.gov/35104110/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX2,ENSG00000268738,CTA,32401813,Collagen methionine sulfoxide and glucuronidine/LW-1 are markers of coronary artery disease in long-term survivors with type 1 diabetes. The Dialong study.,2020,10.1371/journal.pone.0233174,https://pubmed.ncbi.nlm.nih.gov/32401813/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX2,ENSG00000268738,CTA,29305779,Evidence of glucuronidation of the glycation product LW-1: tentative structure and implications for the long-term complications of diabetes.,2018,10.1007/s10719-017-9810-7,https://pubmed.ncbi.nlm.nih.gov/29305779/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX2,ENSG00000268738,CTA,26864236,Skin collagen fluorophore LW-1 versus skin fluorescence as markers for the long-term progression of subclinical macrovascular disease in type 1 diabetes.,2016,10.1186/s12933-016-0343-3,https://pubmed.ncbi.nlm.nih.gov/26864236/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX2,ENSG00000268738,CTA,25703138,Effect of chronic hypoxia on RAGE and its soluble forms in lungs and plasma of mice.,2015,10.1016/j.bbadis.2015.02.003,https://pubmed.ncbi.nlm.nih.gov/25703138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX2,ENSG00000268738,CTA,27342131,The pecking order of skin Advanced Glycation Endproducts (AGEs) as long-term markers of glycemic damage and risk factors for micro- and subclinical macrovascular disease progression in Type 1 diabetes.,2016,10.1007/s10719-016-9702-2,https://pubmed.ncbi.nlm.nih.gov/27342131/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX2,ENSG00000268738,CTA,30103770,De novo transcriptomic assembly and mRNA expression patterns of Botryosphaeria dothidea infection with mycoviruses chrysovirus 1 (BdCV1) and partitivirus 1 (BdPV1).,2018,10.1186/s12985-018-1033-4,https://pubmed.ncbi.nlm.nih.gov/30103770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX2,ENSG00000268738,CTA,15044259,"Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility.",2004,10.1095/biolreprod.103.023580,https://pubmed.ncbi.nlm.nih.gov/15044259/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX2,ENSG00000268738,CTA,22225502,Cloning and functional expression of an acidophilic β-mannanase gene (Anman5A) from Aspergillus niger LW-1 in Pichia pastoris.,2012,10.1021/jf2041565,https://pubmed.ncbi.nlm.nih.gov/22225502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX2,ENSG00000268738,CTA,30785899,Genetic diversity of Mycobacterium tuberculosis complex strains isolated from livestock workers and cattle in Nigeria.,2019,10.1371/journal.pone.0211637,https://pubmed.ncbi.nlm.nih.gov/30785899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX2,ENSG00000268738,CTA,19879855,Partial characterization of the molecular nature of collagen-linked fluorescence: role of diabetes and end-stage renal disease.,2010,10.1016/j.abb.2009.10.013,https://pubmed.ncbi.nlm.nih.gov/19879855/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX2,ENSG00000268738,CTA,21119026,Genetic and environmental influence on diabetic rat embryopathy.,2011,10.1152/ajpendo.00543.2010,https://pubmed.ncbi.nlm.nih.gov/21119026/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX2,ENSG00000268738,CTA,11320634,Post-exercise recovery of autonomic cardiovascular control: a study by spectrum and cross-spectrum analysis in humans.,2001,10.1007/s004210170003,https://pubmed.ncbi.nlm.nih.gov/11320634/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX2,ENSG00000268738,CTA,10148535,Argon laser-welded bovine heterograft anastomoses.,1993,10.1089/clm.1993.11.1,https://pubmed.ncbi.nlm.nih.gov/10148535/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX2,ENSG00000268738,CTA,33599263,Components from spider venom activate macrophages against glioblastoma cells: new potential adjuvants for anticancer immunotherapy.,2021,10.1093/jb/mvab020,https://pubmed.ncbi.nlm.nih.gov/33599263/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,42450814,Y-Linked Expression Signatures Distinguish Dysfunctional Testicular States in Sheep.,2026,10.3390/ani16132107,https://pubmed.ncbi.nlm.nih.gov/42450814/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,40457168,A guide to heat shock factors as multifunctional transcriptional regulators.,2025,10.1111/febs.70139,https://pubmed.ncbi.nlm.nih.gov/40457168/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,40952329,Lnc-&lt;i&gt;HSFY2-10:1&lt;/i&gt; Contributes to Keratinocyte Proliferation and Psoriatic Inflammation Through miR-145-5p/FN1 Axis.,2025,10.1177/10799907251376857,https://pubmed.ncbi.nlm.nih.gov/40952329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,41897406,Divergent Amplification of Y-Linked Dosage-Sensitive Genes Triggers Regulatory Mismatch Underlying Cattle-Yak Male Sterility.,2026,10.3390/biom16030471,https://pubmed.ncbi.nlm.nih.gov/41897406/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,42510778,Isolation and Sequencing of the Y Chromosome in Mediterranean River Buffalo Using Laser Microdissection-Based NGS.,2026,10.3390/genes17070740,https://pubmed.ncbi.nlm.nih.gov/42510778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,37967251,Transcript Isoform Diversity of Ampliconic Genes on the Y Chromosome of Great Apes.,2023,10.1093/gbe/evad205,https://pubmed.ncbi.nlm.nih.gov/37967251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,36461090,Dynamic transcriptome analysis reveals the gene network of gonadal development from the early history life stages in dwarf surfclam Mulinia lateralis.,2022,10.1186/s13293-022-00479-3,https://pubmed.ncbi.nlm.nih.gov/36461090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,38602552,Selection of reference genes for normalizing gene expression data across seasons in spermatozoa of water buffalo (Bubalus bubalis).,2024,10.1007/s00484-024-02675-9,https://pubmed.ncbi.nlm.nih.gov/38602552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,33467186,An 8.22 Mb Assembly and Annotation of the Alpaca (Vicugna pacos) Y Chromosome.,2021,10.3390/genes12010105,https://pubmed.ncbi.nlm.nih.gov/33467186/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,31525193,"Dosage regulation, and variation in gene expression and copy number of human Y chromosome ampliconic genes.",2019,10.1371/journal.pgen.1008369,https://pubmed.ncbi.nlm.nih.gov/31525193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,33766143,Human AZFb deletions cause distinct testicular pathologies depending on their extensions in Yq11 and the Y haplogroup: new cases and review of literature.,2021,10.1186/s13578-021-00551-2,https://pubmed.ncbi.nlm.nih.gov/33766143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,27696014,Expression pattern of HSFY in the mouse testis and epididymis with and without heat stress.,2016,10.1007/s00441-016-2482-y,https://pubmed.ncbi.nlm.nih.gov/27696014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,31103297,"Comparison of Y-chromosome-linked TSPY, TSPY2, and PRAMEY genes in Taurus cattle, yaks, and interspecific hybrid bulls.",2019,10.3168/jds.2018-15680,https://pubmed.ncbi.nlm.nih.gov/31103297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,26055083,Expansion of the HSFY gene family in pig lineages : HSFY expansion in suids.,2015,10.1186/s12864-015-1650-x,https://pubmed.ncbi.nlm.nih.gov/26055083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,36402935,Functional diversification of heat shock factors.,2022,10.1007/s42977-022-00138-z,https://pubmed.ncbi.nlm.nih.gov/36402935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,24507556,"Copy number variations of the extensively amplified Y-linked genes, HSFY and ZNF280BY, in cattle and their association with male reproductive traits in Holstein bulls.",2014,10.1186/1471-2164-15-113,https://pubmed.ncbi.nlm.nih.gov/24507556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,22820855,Deletion or underexpression of the Y-chromosome genes CDY2 and HSFY is associated with maturation arrest in American men with nonobstructive azoospermia.,2012,10.1038/aja.2012.55,https://pubmed.ncbi.nlm.nih.gov/22820855/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,21408193,A large expansion of the HSFY gene family in cattle shows dispersion across Yq and testis-specific expression.,2011,10.1371/journal.pone.0017790,https://pubmed.ncbi.nlm.nih.gov/21408193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,29996948,Long noncoding RNA expression profile and association with SLEDAI score in monocyte-derived dendritic cells from patients with systematic lupus erythematosus.,2018,10.1186/s13075-018-1640-x,https://pubmed.ncbi.nlm.nih.gov/29996948/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,21676392,Heat shock factor Y chromosome (HSFY) mRNA level predicts the presence of retrievable testicular sperm in men with nonobstructive azoospermia.,2011,10.1016/j.fertnstert.2011.05.055,https://pubmed.ncbi.nlm.nih.gov/21676392/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,28588641,The Significant Pathways and Genes Underlying the Colon Cancer Treatment by the Traditional Chinese Medicine PHY906.,2017,10.1155/2017/8753815,https://pubmed.ncbi.nlm.nih.gov/28588641/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,16952509,"Altered expression pattern of heat shock transcription factor, Y chromosome (HSFY) may be related to altered differentiation of spermatogenic cells in testes with deteriorated spermatogenesis.",2006,10.1016/j.fertnstert.2006.01.053,https://pubmed.ncbi.nlm.nih.gov/16952509/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,29177647,"Targeted Deletion of Hsf1, 2, and 4 Genes in Mice.",2018,10.1007/978-1-4939-7477-1_1,https://pubmed.ncbi.nlm.nih.gov/29177647/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,21898223,"Targeted deletion of Hsf1, 2, and 4 genes in mice.",2011,10.1007/978-1-61779-295-3_1,https://pubmed.ncbi.nlm.nih.gov/21898223/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,15044259,"Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility.",2004,10.1095/biolreprod.103.023580,https://pubmed.ncbi.nlm.nih.gov/15044259/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY2,ENSG00000169953,CTA,12815422,The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.,2003,10.1038/nature01722,https://pubmed.ncbi.nlm.nih.gov/12815422/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IHO1,ENSG00000173421,CTA,42415294,Exploring Genetic Contributions to Prostate Cancer Risk in an Asian Population-Based Study.,2026,10.1002/cam4.71971,https://pubmed.ncbi.nlm.nih.gov/42415294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IHO1,ENSG00000173421,CTA,38580643,Seeding the meiotic DNA break machinery and initiating recombination on chromosome axes.,2024,10.1038/s41467-024-47020-1,https://pubmed.ncbi.nlm.nih.gov/38580643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IHO1,ENSG00000173421,CTA,39772748,"Exome sequencing identifies genes for socioeconomic status in 350,770 individuals.",2025,10.1073/pnas.2414018122,https://pubmed.ncbi.nlm.nih.gov/39772748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IHO1,ENSG00000173421,CTA,41706353,A common cause of non-obstructive azoospermia: biallelic MEI1 variants and implications for infertility diagnostics.,2026,10.1007/s10815-026-03807-3,https://pubmed.ncbi.nlm.nih.gov/41706353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IHO1,ENSG00000173421,CTA,27723721,Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice.,2016,10.1038/ncb3417,https://pubmed.ncbi.nlm.nih.gov/27723721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IHO1,ENSG00000173421,CTA,37431931,Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation.,2023,10.15252/embj.2023113866,https://pubmed.ncbi.nlm.nih.gov/37431931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IHO1,ENSG00000173421,CTA,33619545,Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in mice.,2021,10.1093/nar/gkab082,https://pubmed.ncbi.nlm.nih.gov/33619545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IHO1,ENSG00000173421,CTA,35489071,SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination.,2022,10.1093/nar/gkac304,https://pubmed.ncbi.nlm.nih.gov/35489071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IHO1,ENSG00000173421,CTA,33842489,Sycp1 Is Not Required for Subtelomeric DNA Double-Strand Breaks but Is Required for Homologous Alignment in Zebrafish Spermatocytes.,2021,10.3389/fcell.2021.664377,https://pubmed.ncbi.nlm.nih.gov/33842489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IHO1,ENSG00000173421,CTA,38355787,Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders.,2024,10.1038/s41380-024-02446-3,https://pubmed.ncbi.nlm.nih.gov/38355787/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IHO1,ENSG00000173421,CTA,36396648,TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks.,2022,10.1038/s41467-022-34799-0,https://pubmed.ncbi.nlm.nih.gov/36396648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IHO1,ENSG00000173421,CTA,30569039,Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4.,2018,10.26508/lsa.201800259,https://pubmed.ncbi.nlm.nih.gov/30569039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IHO1,ENSG00000173421,CTA,30853435,Prdm9 and Meiotic Cohesin Proteins Cooperatively Promote DNA Double-Strand Break Formation in Mammalian Spermatocytes.,2019,10.1016/j.cub.2019.02.007,https://pubmed.ncbi.nlm.nih.gov/30853435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IHO1,ENSG00000173421,CTA,35791674,FIGNL1 is a potential biomarker of cisplatin resistance in non-small cell lung cancer.,2022,10.1177/03936155221110249,https://pubmed.ncbi.nlm.nih.gov/35791674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IHO1,ENSG00000173421,CTA,28527011,The PRDM9 KRAB domain is required for meiosis and involved in protein interactions.,2017,10.1007/s00412-017-0631-z,https://pubmed.ncbi.nlm.nih.gov/28527011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IHO1,ENSG00000173421,CTA,30333500,The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells.,2018,10.1038/s41598-018-33601-w,https://pubmed.ncbi.nlm.nih.gov/30333500/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,41113993,AIF1L as a Ferroptosis-Linked Biomarker in Microsatellite States-Driven Colorectal Cancer: Functional and Diagnostic Insights From Multiomics Analysis.,2025,10.1155/humu/6663166,https://pubmed.ncbi.nlm.nih.gov/41113993/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,41266833,Single cell RNA sequencing decodes cellular heterogeneity and identifies prognostic immune signatures in bladder cancer microenvironment.,2025,10.1007/s12672-025-03878-1,https://pubmed.ncbi.nlm.nih.gov/41266833/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,37661175,Sirtuin 1 is a potential therapeutic candidate gene for fetal growth restriction via insulin-like 4.,2023,10.1080/14767058.2023.2253486,https://pubmed.ncbi.nlm.nih.gov/37661175/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,34093787,INSL4 as prognostic marker for proliferation and invasiveness in Non-Small-Cell Lung Cancer.,2021,10.7150/jca.51332,https://pubmed.ncbi.nlm.nih.gov/34093787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,39692796,"Prediction of prognosis, efficacy of lung adenocarcinoma by machine learning model based on immune and metabolic related genes.",2024,10.1007/s12672-024-01515-x,https://pubmed.ncbi.nlm.nih.gov/39692796/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,36294477,Comprehensive Analysis of a Novel Immune-Related Gene Signature in Lung Adenocarcinoma.,2022,10.3390/jcm11206154,https://pubmed.ncbi.nlm.nih.gov/36294477/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,36326314,Determination of miRNA expression profile in patients with prostate cancer and benign prostate hyperplasia.,2022,10.55730/1300-0144.5374,https://pubmed.ncbi.nlm.nih.gov/36326314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,36728032,Development and validation of an immune-related gene signature for prognosis in Lung adenocarcinoma.,2023,10.1049/syb2.12057,https://pubmed.ncbi.nlm.nih.gov/36728032/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,30423141,Role of INSL4 Signaling in Sustaining the Growth and Viability of LKB1-Inactivated Lung Cancer.,2019,10.1093/jnci/djy166,https://pubmed.ncbi.nlm.nih.gov/30423141/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,38407877,Molecular subtype identification and prognosis stratification by a immunogenic cell death-related gene expression signature in colorectal cancer.,2024,10.1080/14737140.2024.2320187,https://pubmed.ncbi.nlm.nih.gov/38407877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,27933606,Relaxin-like peptides in male reproduction - a human perspective.,2017,10.1111/bph.13689,https://pubmed.ncbi.nlm.nih.gov/27933606/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,34612148,Exploration of the prognostic signature reflecting tumor microenvironment of lung adenocarcinoma based on immunologically relevant genes.,2021,10.1080/21655979.2021.1974779,https://pubmed.ncbi.nlm.nih.gov/34612148/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,28675750,Expression of placental regulatory genes is associated with fetal growth.,2017,10.1515/jpm-2017-0064,https://pubmed.ncbi.nlm.nih.gov/28675750/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,23302396,"Relaxin, its receptor (RXFP1), and insulin-like peptide 4 expression through gestation and in placenta accreta.",2013,10.1177/1933719112472735,https://pubmed.ncbi.nlm.nih.gov/23302396/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,29623915,The relaxin peptide family - potential future hope for neuroprotective therapy? A short review.,2018,10.4103/1673-5374.228713,https://pubmed.ncbi.nlm.nih.gov/29623915/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,33102522,Identification of a Novel Tumor Microenvironment-Associated Eight-Gene Signature for Prognosis Prediction in Lung Adenocarcinoma.,2020,10.3389/fmolb.2020.571641,https://pubmed.ncbi.nlm.nih.gov/33102522/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,26430762,Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula.,2015,10.1371/journal.pone.0139342,https://pubmed.ncbi.nlm.nih.gov/26430762/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,15958731,Early placental insulin-like protein (INSL4 or EPIL) in placental and fetal membrane growth.,2005,10.1095/biolreprod.105.039859,https://pubmed.ncbi.nlm.nih.gov/15958731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,24973563,Relaxin-related gene expression differs between anadromous and stream-resident stickleback (Gasterosteus aculeatus) following seawater transfer.,2014,10.1016/j.ygcen.2014.06.017,https://pubmed.ncbi.nlm.nih.gov/24973563/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,12606452,Placenta-specific INSL4 expression is mediated by a human endogenous retrovirus element.,2003,10.1095/biolreprod.102.010322,https://pubmed.ncbi.nlm.nih.gov/12606452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,10372742,Pro-EPIL forms are present in amniotic fluid and maternal serum during normal pregnancy.,1999,10.1210/jcem.84.6.5888,https://pubmed.ncbi.nlm.nih.gov/10372742/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,12414911,Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells.,2002,10.1210/jc.2002-021093,https://pubmed.ncbi.nlm.nih.gov/12414911/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL4,ENSG00000120211,CTA,9740319,Insulin-like 4 (INSL4) gene expression in human embryonic and trophoblastic tissues.,1998,10.1002/(sici)1098-2795(199810)51:2<123::aid-mrd1>3.0.co;2-s,https://pubmed.ncbi.nlm.nih.gov/9740319/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCF1,ENSG00000173389,CTA,37956402,Dopamine receptor D2 regulates genes involved in germ cell movement and sperm motility in rat testes†.,2024,10.1093/biolre/ioad153,https://pubmed.ncbi.nlm.nih.gov/37956402/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCF1,ENSG00000173389,CTA,38796713,Elucidating the impact of Y chromosome microdeletions and altered gene expression on male fertility in assisted reproduction.,2024,10.1093/hmg/ddae086,https://pubmed.ncbi.nlm.nih.gov/38796713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCF1,ENSG00000173389,CTA,25380116,"A novel acrosomal protein, IQCF1, involved in sperm capacitation and the acrosome reaction.",2015,10.1111/andr.296,https://pubmed.ncbi.nlm.nih.gov/25380116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCF1,ENSG00000173389,CTA,34068856,Copy Number Profiles of Prostate Cancer in Men of Middle Eastern Ancestry.,2021,10.3390/cancers13102363,https://pubmed.ncbi.nlm.nih.gov/34068856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCF2,ENSG00000184345,CTA,34068856,Copy Number Profiles of Prostate Cancer in Men of Middle Eastern Ancestry.,2021,10.3390/cancers13102363,https://pubmed.ncbi.nlm.nih.gov/34068856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCF3,ENSG00000229972,CTA,32450567,Functional Annotations of Single-Nucleotide Polymorphism (SNP)-Based and Gene-Based Genome-Wide Association Studies Show Genes Affecting Keratitis Susceptibility.,2020,10.12659/msm.922710,https://pubmed.ncbi.nlm.nih.gov/32450567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCF5,ENSG00000214681,CTA,34068856,Copy Number Profiles of Prostate Cancer in Men of Middle Eastern Ancestry.,2021,10.3390/cancers13102363,https://pubmed.ncbi.nlm.nih.gov/34068856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCF6,ENSG00000214686,CTA,35194111,Weighted correlation network analysis revealed novel long non-coding RNAs for colorectal cancer.,2022,10.1038/s41598-022-06934-w,https://pubmed.ncbi.nlm.nih.gov/35194111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCF6,ENSG00000214686,CTA,34068856,Copy Number Profiles of Prostate Cancer in Men of Middle Eastern Ancestry.,2021,10.3390/cancers13102363,https://pubmed.ncbi.nlm.nih.gov/34068856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,42595204,Ythdf family m&lt;sup&gt;6&lt;/sup&gt;A readers promote retinal ganglion cell fate reprogramming and neurite development.,2026,10.1016/j.exer.2026.111204,https://pubmed.ncbi.nlm.nih.gov/42595204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,41791385,Mettl3 promotes reprogramming and axonogenesis of induced retinal ganglion cells.,2026,10.1016/j.stemcr.2026.102851,https://pubmed.ncbi.nlm.nih.gov/41791385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,40276749,A central role for Numb/Nbl in multiple Shh-mediated axon repulsion processes.,2025,10.1016/j.isci.2025.112293,https://pubmed.ncbi.nlm.nih.gov/40276749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,42776783,Whole Genome Sequencing of the Moruga Hill Rice (&lt;i&gt;Oryza glaberrima&lt;/i&gt;) Reveals Its African Ancestry and the Presence of Candidate Stress-Tolerance Genes.,2026,10.3390/biotech15040073,https://pubmed.ncbi.nlm.nih.gov/42776783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,35618043,"IRGC1, a testis-enriched immunity related GTPase, is important for fibrous sheath integrity and sperm motility in mice.",2022,10.1016/j.ydbio.2022.05.011,https://pubmed.ncbi.nlm.nih.gov/35618043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,37195149,The immunity-related GTPase IRGC mediates interaction between lipid droplets and mitochondria to facilitate sperm motility.,2023,10.1002/1873-3468.14640,https://pubmed.ncbi.nlm.nih.gov/37195149/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,42211479,A multi-model genotype × environment interaction analysis discerning phenotypic plasticity of the strong culm trait in rice.,2026,10.3389/fpls.2026.1727579,https://pubmed.ncbi.nlm.nih.gov/42211479/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,39918681,Deciphering Regulatory Networks Governing Seedling Emergence in Deep-Sown Direct-Seeded Rice Cultivation.,2025,10.1186/s12284-025-00760-0,https://pubmed.ncbi.nlm.nih.gov/39918681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,38935030,Shootin1 Regulates Retinal Ganglion Cell Neurite Development: Insights From an RGC Direct Somatic Cell Reprogramming Model.,2024,10.1167/iovs.65.6.41,https://pubmed.ncbi.nlm.nih.gov/38935030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,41184893,Müller glia-mediated protection of retinal ganglion cells from ethambutol-induced neurotoxicity through brain-derived neurotrophic factor.,2025,10.1186/s12964-025-02478-4,https://pubmed.ncbi.nlm.nih.gov/41184893/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,40438160,"Haplotype characterization of phosphorus homeostasis gene, &lt;i&gt;SPX-MFS3&lt;/i&gt; under combination of low nitrogen and phosphorus conditions in &lt;i&gt;indica&lt;/i&gt; rice at seedling stage.",2025,10.1007/s13205-025-04350-1,https://pubmed.ncbi.nlm.nih.gov/40438160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,36368332,Directly induced human retinal ganglion cells mimic fetal RGCs and are neuroprotective after transplantation in vivo.,2022,10.1016/j.stemcr.2022.10.011,https://pubmed.ncbi.nlm.nih.gov/36368332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,40360508,Nutritional and cooking quality superiority of black rice genotype BPT 2841 with enhanced lysine content.,2025,10.1038/s41598-025-00440-5,https://pubmed.ncbi.nlm.nih.gov/40360508/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,40982209,Expression profiling of flowering time pathway in the L-ascorbate peroxidase 9 (APX9) near-isogenic line derived from an interspecific cross between Korean Japonica rice (Oryza sativa L.) and Oryza rufipogon.,2025,10.1007/s13258-025-01683-2,https://pubmed.ncbi.nlm.nih.gov/40982209/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,39214263,Transcriptomic and functional analysis of the antiviral response of mussels after a poly I:C stimulation.,2024,10.1016/j.fsi.2024.109867,https://pubmed.ncbi.nlm.nih.gov/39214263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,35988153,Multiomic Analysis of Neurons with Divergent Projection Patterns Identifies Novel Regulators of Axon Pathfinding.,2022,10.1002/advs.202200615,https://pubmed.ncbi.nlm.nih.gov/35988153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,39930388,"Comparative metabolites analysis of resistant, susceptible and wild rice species in response to bacterial blight disease.",2025,10.1186/s12870-025-06154-0,https://pubmed.ncbi.nlm.nih.gov/39930388/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,40935074,Navigating rice culm resilience: High-throughput quantitative trait locus mapping in indica and tropical japonica derived population.,2026,10.1016/j.plantsci.2025.112756,https://pubmed.ncbi.nlm.nih.gov/40935074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,37540379,The efficient induction of human retinal ganglion-like cells provides a platform for studying optic neuropathies.,2023,10.1007/s00018-023-04890-w,https://pubmed.ncbi.nlm.nih.gov/37540379/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,36297015,Whole Exome Sequencing Study Identifies Novel Rare Risk Variants for Habitual Coffee Consumption Involved in Olfactory Receptor and Hyperphagia.,2022,10.3390/nu14204330,https://pubmed.ncbi.nlm.nih.gov/36297015/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,41047369,The International Risk Governance Council: Reflections on a 20-Year Experiment in Support of Improved Risk Governance.,2025,10.1111/risa.70117,https://pubmed.ncbi.nlm.nih.gov/41047369/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,34528215,"Systematising Pharmacovigilance Engagement of Patients, Healthcare Professionals and Regulators: A Practical Decision Guide Derived from the International Risk Governance Framework for Engagement Events and Discourse.",2021,10.1007/s40264-021-01111-w,https://pubmed.ncbi.nlm.nih.gov/34528215/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,36229818,Stakeholders analysis of COVID-19 management and control: a case of Iran.,2022,10.1186/s12889-022-14219-0,https://pubmed.ncbi.nlm.nih.gov/36229818/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,34594139,Regular COVID-19 Pandemic Containment in Communities: A Risk Governance Perspective.,2021,10.2147/rmhp.s316509,https://pubmed.ncbi.nlm.nih.gov/34594139/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,33932677,"Status, fuzzy integrated risk assessment, and hierarchical risk management of soil heavy metals across China: A systematic review.",2021,10.1016/j.scitotenv.2021.147180,https://pubmed.ncbi.nlm.nih.gov/33932677/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,37889708,Genome-Wide Re-Sequencing Data Reveals the Population Structure and Selection Signatures of Tunchang Pigs in China.,2023,10.3390/ani13111835,https://pubmed.ncbi.nlm.nih.gov/37889708/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,25705117,"Development and GBS-genotyping of introgression lines (ILs) using two wild species of rice, O. meridionalis and O. rufipogon, in a common recurrent parent, O. sativa cv. Curinga.",2015,10.1007/s11032-015-0276-7,https://pubmed.ncbi.nlm.nih.gov/25705117/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,21446401,"Coping with complexity, uncertainty and ambiguity in risk governance: a synthesis.",2011,10.1007/s13280-010-0134-0,https://pubmed.ncbi.nlm.nih.gov/21446401/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRGC,ENSG00000124449,CTA,16850315,Fine mapping of a grain weight quantitative trait locus on rice chromosome 8 using near-isogenic lines derived from a cross between Oryza sativa and Oryza rufipogon.,2006,10.1007/s00122-006-0348-5,https://pubmed.ncbi.nlm.nih.gov/16850315/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,42176245,Rat DCST1 and DCST2 are essential for sperm-egg fusion†.,2026,10.1093/biolre/ioag111,https://pubmed.ncbi.nlm.nih.gov/42176245/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,41233479,Spermatozoa lacking TEX51 display hypofertility and defects in morphology.,2025,10.1038/s42003-025-08937-5,https://pubmed.ncbi.nlm.nih.gov/41233479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,42365233,Sperm surface protein disulfide isomerase ERp57 is crucial for mammalian fertilization but functions independently of IZUMO1.,2026,10.1186/s11658-026-00984-y,https://pubmed.ncbi.nlm.nih.gov/42365233/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,40760720,Uncovering the Role of IZUMO Family Members in Human Fertilization.,2025,10.1002/mrd.70040,https://pubmed.ncbi.nlm.nih.gov/40760720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,40858532,Multi-state catch bond formed in the Izumo1:Juno complex that initiates human fertilization.,2025,10.1038/s41467-025-62427-0,https://pubmed.ncbi.nlm.nih.gov/40858532/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,40051524,The circadian clock orchestrates spermatogonial differentiation and fertilization by regulating retinoic acid signaling in vertebrates.,2025,10.1093/nsr/nwae456,https://pubmed.ncbi.nlm.nih.gov/40051524/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,38484673,Expression of IZUMO1 and JUNO in the gonads of domestic cats (Felis catus).,2024,10.1016/j.theriogenology.2024.02.032,https://pubmed.ncbi.nlm.nih.gov/38484673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,42920325,A Novel Homozygous ZPBP Frameshift Variant Is Associated With Severe Acrosomal Structural Abnormalities in Asthenoteratozoospermia.,2026,10.1111/andr.70395,https://pubmed.ncbi.nlm.nih.gov/42920325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,39767756,Decoding the Genes Orchestrating Egg and Sperm Fusion Reactions and Their Roles in Fertility.,2024,10.3390/biomedicines12122850,https://pubmed.ncbi.nlm.nih.gov/39767756/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,41799926,JUNO-coated beads as a functional assay to capture and characterize fertilization-competent human sperm.,2026,10.1093/hropen/hoag010,https://pubmed.ncbi.nlm.nih.gov/41799926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,39454481,Rat copper transport protein 2 (CTR2) is involved in fertilization through interaction with IZUMO1 and JUNO.,2025,10.1016/j.theriogenology.2024.10.016,https://pubmed.ncbi.nlm.nih.gov/39454481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,38027210,RNA sequencing profiles reveals progressively reduced spermatogenesis with progression in adult cryptorchidism.,2023,10.3389/fendo.2023.1271724,https://pubmed.ncbi.nlm.nih.gov/38027210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,40058809,Molecular mechanisms leading to gamete fusion.,2025,10.5387/fms.24-00046,https://pubmed.ncbi.nlm.nih.gov/40058809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,40469420,Immunolocalization and proteomic analyses of IZUMO1 in porcine spermatozoa.,2025,10.3389/fcell.2025.1576881,https://pubmed.ncbi.nlm.nih.gov/40469420/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,40711049,"Impact of Polystyrene Microplastics on Human Sperm Functionality: An In Vitro Study of Cytotoxicity, Genotoxicity and Fertility-Related Genes Expression.",2025,10.3390/toxics13070605,https://pubmed.ncbi.nlm.nih.gov/40711049/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,42810236,Use of plant-derived compounds for chilled gamete storage in felids and canids.,2027,10.1016/j.theriogenology.2026.118226,https://pubmed.ncbi.nlm.nih.gov/42810236/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,35409288,The Role of Sperm Proteins IZUMO1 and TMEM95 in Mammalian Fertilization: A Systematic Review.,2022,10.3390/ijms23073929,https://pubmed.ncbi.nlm.nih.gov/35409288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,38612267,"Detection of Protein Biomarkers Relevant to Sperm Characteristics and Fertility in Semen in Three Wild Felidae: The Flat-Headed Cat (Prionailurus planiceps), Fishing Cat (Prionailurus viverrinus), and Asiatic Golden Cat (Catopuma temminckii).",2024,10.3390/ani14071027,https://pubmed.ncbi.nlm.nih.gov/38612267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,39044583,[Functions and mechanisms of testicular descent in Apodemus agrarius based on transcriptomics and metabolomics].,2024,10.13345/j.cjb.240025,https://pubmed.ncbi.nlm.nih.gov/39044583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,38001873,IZUMO1 Receptor Localization during Hyaluronic Acid Selection in Human Spermatozoa.,2023,10.3390/biomedicines11112872,https://pubmed.ncbi.nlm.nih.gov/38001873/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,41354026,Role of adjuvants in the efficacy of an IZUMO1-based immunocontraceptive vaccine in mice.,2026,10.1016/j.vaccine.2025.128071,https://pubmed.ncbi.nlm.nih.gov/41354026/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,42772050,"Comparative analysis of immunocontraceptive vaccines in wild animals: Modes of action, molecular targets, and immunological responses.",2026,10.1016/j.jri.2026.104969,https://pubmed.ncbi.nlm.nih.gov/42772050/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,35688940,Live imaging-based assay for visualising species-specific interactions in gamete adhesion molecules.,2022,10.1038/s41598-022-13547-w,https://pubmed.ncbi.nlm.nih.gov/35688940/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,34943185,Evaluation of Global DNA Methylation and Gene Expression of Izumo1 and Izumo1r in Gonads after High- and Low-Dose Radiation in Neonatal Mice.,2021,10.3390/biology10121270,https://pubmed.ncbi.nlm.nih.gov/34943185/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,33930667,Evaluation of multi-epitope recombinant protein as a candidate for a contraceptive vaccine.,2021,10.1016/j.jri.2021.103325,https://pubmed.ncbi.nlm.nih.gov/33930667/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,30790628,Detecting coevolution of positively selected in turtles sperm-egg fusion proteins.,2019,10.1016/j.mod.2019.02.001,https://pubmed.ncbi.nlm.nih.gov/30790628/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,38885964,"Variation of sperm quality and circular RNA content in men exposed to environmental contamination with heavy metals in 'Land of Fires', Italy.",2024,10.1093/humrep/deae109,https://pubmed.ncbi.nlm.nih.gov/38885964/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,36972453,Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin.,2023,10.1073/pnas.2221255120,https://pubmed.ncbi.nlm.nih.gov/36972453/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,26782177,Vaccination with an Epitope Peptide of IZUMO1 to Induce Contraception in Female Mice.,2016,10.1111/aji.12485,https://pubmed.ncbi.nlm.nih.gov/26782177/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,36614032,Improvement of Fertilization Capacity and Developmental Ability of Vitrified Bovine Oocytes by JUNO mRNA Microinjection and Cholesterol-Loaded Methyl-β-Cyclodextrin Treatment.,2022,10.3390/ijms24010590,https://pubmed.ncbi.nlm.nih.gov/36614032/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,34095128,Oolemma Receptors in Mammalian Molecular Fertilization: Function and New Methods of Study.,2021,10.3389/fcell.2021.662032,https://pubmed.ncbi.nlm.nih.gov/34095128/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,31575859,Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization.,2019,10.1038/s41467-019-12406-z,https://pubmed.ncbi.nlm.nih.gov/31575859/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,23279005,Presence and incidence of izumo antibodies in sera of immunoinfertile women and men.,2013,10.1111/aji.12060,https://pubmed.ncbi.nlm.nih.gov/23279005/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,25937952,Construction and Analysis of the Cell Surface's Protein Network for Human Sperm-Egg Interaction.,2013,10.1155/2013/962760,https://pubmed.ncbi.nlm.nih.gov/25937952/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,26469117,Brdt Bromodomains Inhibitors and Other Modern Means of Male Contraception.,2015,10.17219/acem/33827,https://pubmed.ncbi.nlm.nih.gov/26469117/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,29699139,Critical role of exosomes in sperm-egg fusion and virus-induced cell-cell fusion.,2013,10.1007/s12522-013-0152-2,https://pubmed.ncbi.nlm.nih.gov/29699139/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,36070373,"MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization.",2022,10.1126/sciadv.abn0047,https://pubmed.ncbi.nlm.nih.gov/36070373/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO1,ENSG00000182264,CTA,15759005,The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs.,2005,10.1038/nature03362,https://pubmed.ncbi.nlm.nih.gov/15759005/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO3,ENSG00000205442,CTA,42140156,Arginine and putrescine ameliorate heat stress-induced testicular inflammation and apoptosis via inhibiting endoplasmic reticulum stress in mice.,2026,10.1016/j.theriogenology.2026.117987,https://pubmed.ncbi.nlm.nih.gov/42140156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO3,ENSG00000205442,CTA,28975488,Association of TUSC1 and DPF3 gene polymorphisms with male infertility.,2018,10.1007/s10815-017-1052-x,https://pubmed.ncbi.nlm.nih.gov/28975488/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO3,ENSG00000205442,CTA,28181694,"A Genomewide Association Study Identifies Two Sex-Specific Loci, at SPTB and IZUMO3, Influencing Pediatric Bone Mineral Density at Multiple Skeletal Sites.",2017,10.1002/jbmr.3097,https://pubmed.ncbi.nlm.nih.gov/28181694/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO3,ENSG00000205442,CTA,22957301,Positive Selection and the Evolution of izumo Genes in Mammals.,2012,10.1155/2012/958164,https://pubmed.ncbi.nlm.nih.gov/22957301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,42814764,Zinc is a key regulator of the sperm-specific K&lt;sup&gt;+&lt;/sup&gt; channel (Slo3) function.,2026,10.7554/elife.105450,https://pubmed.ncbi.nlm.nih.gov/42814764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,40969884,Highly Potent and Subtype-Selective Sperm-Specific Potassium Channel SLO3 Inhibitors Display High Tissue Exposure in the Murine Female Reproductive Tract.,2025,10.1021/acsptsci.5c00416,https://pubmed.ncbi.nlm.nih.gov/40969884/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,37446382,SLO3: A Conserved Regulator of Sperm Membrane Potential.,2023,10.3390/ijms241311205,https://pubmed.ncbi.nlm.nih.gov/37446382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,40358624,Differential molecular interactions between iberiotoxin and human SLO3 and SLO1 potassium channels.,2025,10.1007/s00894-025-06379-8,https://pubmed.ncbi.nlm.nih.gov/40358624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,38927088,pH Homeodynamics and Male Fertility: A Coordinated Regulation of Acid-Based Balance during Sperm Journey to Fertilization.,2024,10.3390/biom14060685,https://pubmed.ncbi.nlm.nih.gov/38927088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,38786087,Cytosolic and Acrosomal pH Regulation in Mammalian Sperm.,2024,10.3390/cells13100865,https://pubmed.ncbi.nlm.nih.gov/38786087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,39476963,The sodium-proton exchangers sNHE and NHE1 control plasma membrane hyperpolarization in mouse sperm.,2024,10.1016/j.jbc.2024.107932,https://pubmed.ncbi.nlm.nih.gov/39476963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,38637987,Transmembrane determinants of voltage-gating differences between BK (Slo1) and Slo3 channels.,2024,10.1016/j.bpj.2024.04.016,https://pubmed.ncbi.nlm.nih.gov/38637987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,39310227,The sperm-specific K+ channel Slo3 is inhibited by albumin and steroids contained in reproductive fluids.,2024,10.3389/fcell.2024.1275116,https://pubmed.ncbi.nlm.nih.gov/39310227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,38436215,"Physiological role of potassium channels in mammalian germ cell differentiation, maturation, and capacitation.",2025,10.1111/andr.13606,https://pubmed.ncbi.nlm.nih.gov/38436215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,39416520,"Molecular mechanisms of mammalian sperm capacitation, and its regulation by sodium-dependent secondary active transporters.",2024,10.1002/rmb2.12614,https://pubmed.ncbi.nlm.nih.gov/39416520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,36791103,SLO3 in the fast lane: The latest male contraceptive target with a promising small-molecule inhibitor.,2023,10.1073/pnas.2221758120,https://pubmed.ncbi.nlm.nih.gov/36791103/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,31270758,A cytoplasmic Slo3 isoform is expressed in somatic tissues.,2019,10.1007/s11033-019-04943-z,https://pubmed.ncbi.nlm.nih.gov/31270758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,36649421,A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function.,2023,10.1073/pnas.2212338120,https://pubmed.ncbi.nlm.nih.gov/36649421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,38803392,Membrane potential hyperpolarization: a critical factor in acrosomal exocytosis and fertilization in sperm within the female reproductive tract.,2024,10.3389/fcell.2024.1386980,https://pubmed.ncbi.nlm.nih.gov/38803392/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,34980136,Homozygous mutation in SLO3 leads to severe asthenoteratozoospermia due to acrosome hypoplasia and mitochondrial sheath malformations.,2022,10.1186/s12958-021-00880-4,https://pubmed.ncbi.nlm.nih.gov/34980136/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,39764877,"The hematopoietic function, histological characteristics, and transcriptome profiling of Wanxi white geese ovary during nesting and late-laying stages.",2025,10.1016/j.psj.2025.104764,https://pubmed.ncbi.nlm.nih.gov/39764877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,37175513,Pharmacological Evidence Suggests That Slo3 Channel Is the Principal K+ Channel in Boar Spermatozoa.,2023,10.3390/ijms24097806,https://pubmed.ncbi.nlm.nih.gov/37175513/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,32564653,The Slo3/Lrrc52 complex is sensitive to phosphoinositides.,2020,10.1080/19336950.2020.1778393,https://pubmed.ncbi.nlm.nih.gov/32564653/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,35551387,Bi-allelic variants in KCNU1 cause impaired acrosome reactions and male infertility.,2022,10.1093/humrep/deac102,https://pubmed.ncbi.nlm.nih.gov/35551387/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,30422808,Slo3 K+ channel blocker clofilium extends bull and mouse sperm-fertilizing competence.,2018,10.1530/rep-18-0075,https://pubmed.ncbi.nlm.nih.gov/30422808/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,32782607,A 10-gene signature as a predictor of biochemical recurrence after radical prostatectomy in patients with prostate cancer and a Gleason score ≥7.,2020,10.3892/ol.2020.11830,https://pubmed.ncbi.nlm.nih.gov/32782607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,32534924,Effects of timing of artificial insemination and treatment of semen with a Slo3 potassium channel blocker on fertility of dairy heifers subjected to the 5-day CIDR-Synch protocol.,2020,10.3168/jds.2019-18103,https://pubmed.ncbi.nlm.nih.gov/32534924/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,25675513,SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility.,2015,10.1073/pnas.1423869112,https://pubmed.ncbi.nlm.nih.gov/25675513/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,27627854,Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models.,2016,10.1038/srep33589,https://pubmed.ncbi.nlm.nih.gov/27627854/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,27052499,Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF.,2016,10.1093/humrep/dew056,https://pubmed.ncbi.nlm.nih.gov/27052499/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNU1,ENSG00000215262,CTA,9452476,"Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes.",1998,10.1074/jbc.273.6.3509,https://pubmed.ncbi.nlm.nih.gov/9452476/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1210,ENSG00000250423,CTA,41697014,Loss of KIAA1210 leads to increased pyroptotic cell death in mouse spermatogenesis†.,2026,10.1093/biolre/ioag040,https://pubmed.ncbi.nlm.nih.gov/41697014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1210,ENSG00000250423,CTA,42846478,Whole genome sequencing approach for the detection of rare protein-altering variants associated with familial male infertility.,2025,10.1186/s43042-025-00828-y,https://pubmed.ncbi.nlm.nih.gov/42846478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1210,ENSG00000250423,CTA,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1210,ENSG00000250423,CTA,36017582,Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia.,2022,10.1111/andr.13269,https://pubmed.ncbi.nlm.nih.gov/36017582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1210,ENSG00000250423,CTA,31995159,Novel localizations and interactions of intercellular bridge proteins revealed by proteomic profiling†.,2020,10.1093/biolre/ioaa017,https://pubmed.ncbi.nlm.nih.gov/31995159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1210,ENSG00000250423,CTA,28203736,Identification of KIAA1210 as a novel X-chromosome-linked protein that localizes to the acrosome and associates with the ectoplasmic specialization in testes.,2017,10.1095/biolreprod.116.145458,https://pubmed.ncbi.nlm.nih.gov/28203736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1210,ENSG00000250423,CTA,34791246,Whole-exome sequencing of a cohort of infertile men reveals novel causative genes in teratozoospermia that are chiefly related to sperm head defects.,2021,10.1093/humrep/deab229,https://pubmed.ncbi.nlm.nih.gov/34791246/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1210,ENSG00000250423,CTA,29927686,Loci-specific differences in blood DNA methylation in HBV-negative populations at risk for hepatocellular carcinoma development.,2018,10.1080/15592294.2018.1481706,https://pubmed.ncbi.nlm.nih.gov/29927686/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1210,ENSG00000250423,CTA,35654582,FSIP2 plays a role in the acrosome development during spermiogenesis.,2023,10.1136/jmedgenet-2021-108406,https://pubmed.ncbi.nlm.nih.gov/35654582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1210,ENSG00000250423,CTA,16489065,PDLIM4 repression by hypermethylation as a potential biomarker for prostate cancer.,2006,10.1158/1078-0432.ccr-05-2072,https://pubmed.ncbi.nlm.nih.gov/16489065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,42325760,LncRNA CDIPTOSP-induced destabilization of KLF17 promotes ovarian cancer progression through STAU1-mediated mRNA decay.,2026,10.62347/nzis8956,https://pubmed.ncbi.nlm.nih.gov/42325760/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,41775633,Novel EPS15 :: KLF17 and EPS15L1 :: KLF17 Fusions Define a Distinctive Group of MUC4-Positive Spindled to Epithelioid Sarcomas.,2026,10.1097/pas.0000000000002520,https://pubmed.ncbi.nlm.nih.gov/41775633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,41795994,[Myoepithelial tumor of soft tissue with EWSR1::KLF17 fusion: report of a case].,2026,10.3760/cma.j.cn112151-20250603-00382,https://pubmed.ncbi.nlm.nih.gov/41795994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,40866457,The chloroform fraction of Dracontium spruceanum modulates gene expression in gastric cancer stem cells.,2025,10.1038/s41598-025-15172-9,https://pubmed.ncbi.nlm.nih.gov/40866457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,40292574,Krüppel-like factors play essential roles in regulating pluripotency and the formation of neural crest stem cells.,2025,10.1242/dev.204634,https://pubmed.ncbi.nlm.nih.gov/40292574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,41755639,Nascent transcriptome of embryonic genome activation reveals a regulatory axis linking transcriptional priming to early lineage specification in mouse embryos.,2026,10.1093/nar/gkag173,https://pubmed.ncbi.nlm.nih.gov/41755639/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,41201092,Protocol to rapidly verify silent gene reporter in human pluripotent stem cells using CRISPR activation.,2025,10.1016/j.xpro.2025.104164,https://pubmed.ncbi.nlm.nih.gov/41201092/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,41986233,KLF18 is a necessary component of the DUX4-initiated transcriptional network and a candidate locus for phenotypic diversity.,2026,10.1101/gad.353253.125,https://pubmed.ncbi.nlm.nih.gov/41986233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,40878925,Pseudoglandular Schwannoma With FUS::KLF17 Fusion: Broadening the Spectrum of FUS-Associated Tumors.,2025,10.1002/gcc.70077,https://pubmed.ncbi.nlm.nih.gov/40878925/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,40812719,Anti-tumor activity of CDYL2b in prostate cancer.,2025,10.1016/j.canlet.2025.217987,https://pubmed.ncbi.nlm.nih.gov/40812719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,41453673,ATAC-seq revealing chromatin accessibility and novel motifs linked to corneal fibrosis.,2026,10.1016/j.exer.2025.110826,https://pubmed.ncbi.nlm.nih.gov/41453673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,42644820,α-Ketoglutarate enhances epigenetic remodeling and developmental competence in porcine SCNT embryos.,2026,10.1093/reprod/xaag103,https://pubmed.ncbi.nlm.nih.gov/42644820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,41342886,FET-Rearranged Myoepithelial Tumors Are Clinically Heterogeneous and Epigenetically Distinct from PLAG1-Rearranged Adnexal and Salivary Gland Myoepithelial Tumors.,2026,10.1158/1078-0432.ccr-25-2426,https://pubmed.ncbi.nlm.nih.gov/41342886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,40652737,DUXA regulates the early development of porcine cloned embryos.,2025,10.1016/j.theriogenology.2025.117563,https://pubmed.ncbi.nlm.nih.gov/40652737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,37563131,Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis.,2023,10.1038/s41598-023-39196-1,https://pubmed.ncbi.nlm.nih.gov/37563131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,38325372,Maternal KLF17 controls zygotic genome activation by acting as a messenger for RNA Pol II recruitment in mouse embryos.,2024,10.1016/j.devcel.2024.01.013,https://pubmed.ncbi.nlm.nih.gov/38325372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,42114359,An Updated Conceptual Framework for Myoepithelial Tumors of Soft tissues and Bone: Toward a Molecularly Informed Classification.,2026,10.1016/j.semdp.2026.151014,https://pubmed.ncbi.nlm.nih.gov/42114359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,38149566,Anti-oncogenic mechanism of KLF17 in colon cancer by repressing cell migration and invasion via FHL1 upregulation.,2023,10.4103/cjop.cjop-d-23-00084,https://pubmed.ncbi.nlm.nih.gov/38149566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,38162669,KLF17 is an important regulatory component of the transcriptomic response of Atlantic salmon macrophages to Piscirickettsia salmonis infection.,2023,10.3389/fimmu.2023.1264599,https://pubmed.ncbi.nlm.nih.gov/38162669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,34738482,Effect of KLF17 overexpression on epithelial-mesenchymal transition of gastric cancer cells.,2021,10.1177/03000605211051581,https://pubmed.ncbi.nlm.nih.gov/34738482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,35345512,Expression and Prognosis Value of the KLF Family Members in Colorectal Cancer.,2022,10.1155/2022/6571272,https://pubmed.ncbi.nlm.nih.gov/35345512/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,39215019,Prognostic value of KLFs family genes in renal clear cell carcinoma.,2024,10.1038/s41598-024-69892-5,https://pubmed.ncbi.nlm.nih.gov/39215019/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,25437182,Proteomic profile and in silico analysis in metastatic melanoma with and without BRAF mutation.,2014,10.1371/journal.pone.0112025,https://pubmed.ncbi.nlm.nih.gov/25437182/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,26293300,Defining the three cell lineages of the human blastocyst by single-cell RNA-seq.,2015,10.1242/dev.123547,https://pubmed.ncbi.nlm.nih.gov/26293300/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLF17,ENSG00000171872,CTA,26506092,klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes.,2015,10.1371/journal.pone.0141611,https://pubmed.ncbi.nlm.nih.gov/26506092/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,41198842,The use of environmental RNA for inferring fish spawning behavior.,2025,10.1038/s41598-025-23861-8,https://pubmed.ncbi.nlm.nih.gov/41198842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,42032408,Effect of the Vesicular Fraction of Donor Semen Plasma on the Expression of AURKA and KLHL10 Genes in Cryopreserved Spermatozoa.,2026,10.1007/s10517-026-06651-8,https://pubmed.ncbi.nlm.nih.gov/42032408/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,41611118,Triploidy alters hormonal and paracrine signaling to promote male development in zebrafish.,2026,10.1016/j.mce.2026.112740,https://pubmed.ncbi.nlm.nih.gov/41611118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,39982357,Utilizing C. elegans Spermatogenesis and Fertilization Mutants as a Model for Human Disease.,2025,10.3390/jdb13010004,https://pubmed.ncbi.nlm.nih.gov/39982357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,34433733,The I510V mutation in KLHL10 in a patient with oligoasthenoteratozoospermia.,2021,10.1262/jrd.2021-063,https://pubmed.ncbi.nlm.nih.gov/34433733/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,36091389,Identification and functional analysis of Tex11 and Meig1 in spermatogenesis of Hyriopsis cumingii.,2022,10.3389/fphys.2022.961773,https://pubmed.ncbi.nlm.nih.gov/36091389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,32655042,Next-generation sequencing: toward an increase in the diagnostic yield in patients with apparently idiopathic spermatogenic failure.,2021,10.4103/aja.aja_25_20,https://pubmed.ncbi.nlm.nih.gov/32655042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,39856550,Whole-genome resequencing landscape of adaptive evolution in Relict gull (Larus relictus).,2025,10.1186/s12864-025-11257-x,https://pubmed.ncbi.nlm.nih.gov/39856550/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,31065688,Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis.,2020,10.1093/jmcb/mjz035,https://pubmed.ncbi.nlm.nih.gov/31065688/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,30697164,Transcriptomic Analysis Reveals Insights on Male Infertility in Octopus maya Under Chronic Thermal Stress.,2018,10.3389/fphys.2018.01920,https://pubmed.ncbi.nlm.nih.gov/30697164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,33523351,Differential expression analysis and identification of sex-related genes by gonad transcriptome sequencing in estradiol-treated and non-treated Ussuri catfish Pseudobagrus ussuriensis.,2021,10.1007/s10695-021-00932-x,https://pubmed.ncbi.nlm.nih.gov/33523351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,30544396,An in silico analysis of human sperm genes associated with asthenozoospermia and its implication in male infertility.,2018,10.1097/md.0000000000013338,https://pubmed.ncbi.nlm.nih.gov/30544396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,32242295,Development of a novel next-generation sequencing panel for diagnosis of quantitative spermatogenic impairment.,2020,10.1007/s10815-020-01747-0,https://pubmed.ncbi.nlm.nih.gov/32242295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,30629479,Male Fertility Potential Molecular Mechanisms Revealed by iTRAQ-Based Quantitative Proteomic Analysis of the Epididymis from Wip1-/- Mice.,2019,10.1089/omi.2018.0155,https://pubmed.ncbi.nlm.nih.gov/30629479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,37969115,Whole-exome sequencing revealed novel genetic alterations in patients with tetralogy of Fallot.,2023,10.21037/tp-23-449,https://pubmed.ncbi.nlm.nih.gov/37969115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,29731491,Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.,2018,10.1262/jrd.2018-024,https://pubmed.ncbi.nlm.nih.gov/29731491/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,28253373,De novo sequencing and comparative analysis of testicular transcriptome from different reproductive phases in freshwater spotted snakehead Channa punctatus.,2017,10.1371/journal.pone.0173178,https://pubmed.ncbi.nlm.nih.gov/28253373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,17880263,A ubiquitin ligase complex regulates caspase activation during sperm differentiation in Drosophila.,2007,10.1371/journal.pbio.0050251,https://pubmed.ncbi.nlm.nih.gov/17880263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,33933383,"RNA-seq analysis of the mantle transcriptome from Mytilus edulis during a seasonal spawning event in deep and shallow water culture sites on the northeast coast of Newfoundland, Canada.",2021,10.1016/j.margen.2021.100865,https://pubmed.ncbi.nlm.nih.gov/33933383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,15136734,Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice.,2004,10.1073/pnas.0308025101,https://pubmed.ncbi.nlm.nih.gov/15136734/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL10,ENSG00000161594,CTA,35131584,"Role of bioactive xenobiotics towards reproductive potential of Odontotermes longignathus through in silico study: An amalgamation of ecoinformatics and ecotechnological insights of termite mounds from a tropical forest, India.",2022,10.1016/j.ecoenv.2022.113275,https://pubmed.ncbi.nlm.nih.gov/35131584/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6A,ENSG00000166800,CTA,41330386,In vivo proteomic labeling reveals diverse proteomes for therapeutic targets.,2025,10.1016/j.molcel.2025.11.008,https://pubmed.ncbi.nlm.nih.gov/41330386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6A,ENSG00000166800,CTA,27885267,Contributory roles of two l-lactate dehydrogenases for l-lactic acid production in thermotolerant Bacillus coagulans.,2016,10.1038/srep37916,https://pubmed.ncbi.nlm.nih.gov/27885267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6A,ENSG00000166800,CTA,18351441,"Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA).",2009,10.1007/s11033-008-9227-2,https://pubmed.ncbi.nlm.nih.gov/18351441/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6A,ENSG00000166800,CTA,29178877,Non-sterilized fermentation of high optically pure D-lactic acid by a genetically modified thermophilic Bacillus coagulans strain.,2017,10.1186/s12934-017-0827-1,https://pubmed.ncbi.nlm.nih.gov/29178877/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,40336322,LDHAL6B is a novel prognostic marker and promotes disease progression in multiple myeloma.,2025,10.3324/haematol.2024.286835,https://pubmed.ncbi.nlm.nih.gov/40336322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,41574401,"Comprehensive Quantification of Oligoasthenozoospermia Induced by Obesity, Reproductive Toxicants, and Their Combination in Rat Models.",2026,10.1111/andr.70171,https://pubmed.ncbi.nlm.nih.gov/41574401/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,39549775,Lactate dehydrogenase a-like 6B is not essential for spermatogenesis and male fertility in mice.,2025,10.1016/j.gene.2024.149100,https://pubmed.ncbi.nlm.nih.gov/39549775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,39697060,Proteomic analysis for busulfan-induced spermatogenesis disorder.,2025,10.1080/07853890.2024.2442534,https://pubmed.ncbi.nlm.nih.gov/39697060/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,41077284,Enhanced phenyllactic acid production from grass carp viscera hydrolysate using engineered Pediococcus acidilactici.,2026,10.1016/j.biortech.2025.133460,https://pubmed.ncbi.nlm.nih.gov/41077284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,41821540,Overexpression and Characterization of L-Lactate Dehydrogenase from &lt;i&gt;Lacticaseibacillus casei&lt;/i&gt; HY2782 to Control Post-Acidification in Yogurt.,2025,10.5851/kosfa.2025.e25,https://pubmed.ncbi.nlm.nih.gov/41821540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,40719898,Metabolic engineering of Lactobacillus delbrueckii subsp. bulgaricus VI104 as a D-lactic acid cell factory through strategic pathway optimization for enhanced biosynthesis.,2025,10.1007/s11274-025-04489-2,https://pubmed.ncbi.nlm.nih.gov/40719898/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,41407879,Whole-genome sequencing GWAS reveals bovine genomic effects on enteric methane emissions in beef cattle.,2025,10.1038/s41598-025-32815-z,https://pubmed.ncbi.nlm.nih.gov/41407879/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,34290169,CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice.,2022,10.4103/aja.aja_63_21,https://pubmed.ncbi.nlm.nih.gov/34290169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,34884692,Effect of 2-Cys Peroxiredoxins Inhibition on Redox Modifications of Bull Sperm Proteins.,2021,10.3390/ijms222312888,https://pubmed.ncbi.nlm.nih.gov/34884692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,26472127,Reduction of D-lactate content in sauerkraut using starter cultures of recombinant Leuconostoc mesenteroides expressing the ldhL gene.,2016,10.1016/j.jbiosc.2015.09.007,https://pubmed.ncbi.nlm.nih.gov/26472127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,27565144,The Effect of a Newly Developed Oat-Banana Fermented Beverage with a Beta-glucan Additive on ldhL Gene Expression in Streptococcus thermophilus TKM3 KKP 2030p.,2016,10.1007/s00284-016-1126-5,https://pubmed.ncbi.nlm.nih.gov/27565144/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,25861191,Lymphocyte Depleted Hodgkin's Lymphoma Presented with Haemolytic Anemia: A Case Report and Literature Review.,2015,10.1007/s12663-013-0528-1,https://pubmed.ncbi.nlm.nih.gov/25861191/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,25179900,Regulation of metabolic flux in Lactobacillus casei for lactic acid production by overexpressed ldhL gene with two-stage oxygen supply strategy.,2015,10.4014/jmb.1407.07001,https://pubmed.ncbi.nlm.nih.gov/25179900/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,25217009,Major Role of NAD-Dependent Lactate Dehydrogenases in the Production of l-Lactic Acid with High Optical Purity by the Thermophile Bacillus coagulans.,2014,10.1128/aem.01864-14,https://pubmed.ncbi.nlm.nih.gov/25217009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,15870898,Cloning and characterization of a novel intronless lactate dehydrogenase gene in human testis.,2005,10.3892/ijmm.15.6.949,https://pubmed.ncbi.nlm.nih.gov/15870898/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,25104116,L-lactic acid production from D-xylose with Candida sonorensis expressing a heterologous lactate dehydrogenase encoding gene.,2014,10.1186/s12934-014-0107-2,https://pubmed.ncbi.nlm.nih.gov/25104116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,23649263,Utilization of lactic acid bacterial genes in Synechocystis sp. PCC 6803 in the production of lactic acid.,2013,10.1271/bbb.120921,https://pubmed.ncbi.nlm.nih.gov/23649263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,22344644,Relative catalytic efficiency of ldhL- and ldhD-encoded products is crucial for optical purity of lactic acid produced by lactobacillus strains.,2012,10.1128/aem.00058-12,https://pubmed.ncbi.nlm.nih.gov/22344644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,29038973,Production of ethylene glycol or glycolic acid from D-xylose in Saccharomyces cerevisiae.,2017,10.1007/s00253-017-8547-3,https://pubmed.ncbi.nlm.nih.gov/29038973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,40952898,Lactic acid production of bacteria from tree barks and proposal of &lt;i&gt;Sporolactobacillus caesalpiniae&lt;/i&gt; sp. nov.,2025,10.1099/ijsem.0.006915,https://pubmed.ncbi.nlm.nih.gov/40952898/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,26148486,Establishment of markerless gene deletion tools in thermophilic Bacillus smithii and construction of multiple mutant strains.,2015,10.1186/s12934-015-0286-5,https://pubmed.ncbi.nlm.nih.gov/26148486/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,20455948,Comparison of expression vectors in Lactobacillus reuteri strains.,2010,10.1111/j.1574-6968.2010.01978.x,https://pubmed.ncbi.nlm.nih.gov/20455948/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,18061945,Comparative flow immunophenotypic features of the inflammatory infiltrates of Hodgkin lymphoma and lymphoid hyperplasia.,2008,10.1002/cyto.b.20376,https://pubmed.ncbi.nlm.nih.gov/18061945/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHAL6B,ENSG00000171989,CTA,16166538,Lactate racemization as a rescue pathway for supplying D-lactate to the cell wall biosynthesis machinery in Lactobacillus plantarum.,2005,10.1128/jb.187.19.6750-6761.2005,https://pubmed.ncbi.nlm.nih.gov/16166538/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,42801374,Comparative evaluation of germ cell-specific promoters identifies robust drivers of transgene expression during mouse spermatogenesis.,2026,10.1007/s11033-026-12822-7,https://pubmed.ncbi.nlm.nih.gov/42801374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,42792171,LDHC Hyperacetylation Disrupts the Guanidinoacetic Acid-Creatine Axis Underlying Cryoinjury in Boar Sperm: Rescue by GAA Supplementation.,2026,10.3390/antiox15091132,https://pubmed.ncbi.nlm.nih.gov/42792171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,41879946,Comparative study on the functions of LDHA and LDHC in triple-negative breast cancer.,2026,10.1007/s12672-026-04838-z,https://pubmed.ncbi.nlm.nih.gov/41879946/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,41298813,Nicotinamide mononucleotide treatment improves spermatogenesis in obese mice by reducing lysine acetylation of lactate dehydrogenase C.,2025,10.1038/s42003-025-09094-5,https://pubmed.ncbi.nlm.nih.gov/41298813/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,41339282,Lactylation Genes LDHA and LDHC Alleviate Osteoarthritis by Reducing Specific B-Cell Expression: Mechanistic Exploration and Experimental Validation.,2025,10.1111/jcmm.70935,https://pubmed.ncbi.nlm.nih.gov/41339282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,41599186,Cell-Penetrating Peptide-Mediated siRNA Targeting of LDHC Suppresses Tumor Growth in a Triple-Negative Breast Cancer Zebrafish Xenograft Model.,2026,10.3390/pharmaceutics18010078,https://pubmed.ncbi.nlm.nih.gov/41599186/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,41969488,Identification of potential hub biomarkers for gastric high-grade intraepithelial neoplasia early diagnosis: evidence from gene expression profiles and pathological characters.,2026,10.21037/tcr-2025-1-2625,https://pubmed.ncbi.nlm.nih.gov/41969488/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,42369205,Lactylation-Related Genes in Ulcerative Colitis: A Multiomics Mendelian Randomization Study for Therapeutic Target Discovery.,2026,10.1155/humu/7720538,https://pubmed.ncbi.nlm.nih.gov/42369205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,40270965,Identification of new HLA-A*0201-restricted cytotoxic T lymphocyte epitopes from LDHC in lung adenocarcinoma.,2025,10.3389/fimmu.2025.1564731,https://pubmed.ncbi.nlm.nih.gov/40270965/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,39940876,Altered Sertoli Cell Function Contributes to Spermatogenic Arrest in Dogs with Chronic Asymptomatic Orchitis.,2025,10.3390/ijms26031108,https://pubmed.ncbi.nlm.nih.gov/39940876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,40638696,L-2-hydroxyglutarate regulates centromere and heterochromatin conformation in the male germline.,2025,10.1371/journal.pgen.1011785,https://pubmed.ncbi.nlm.nih.gov/40638696/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,41689107,"Genetically predicted expression of EP300, LDHC, and TKT and risk of neurodegenerative diseases.",2026,10.1186/s12967-026-07821-y,https://pubmed.ncbi.nlm.nih.gov/41689107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,40861836,Serous and Exosomal LDH-C4 as a Potential Diagnostic and Prognostic Biomarker of Cervical Carcinoma.,2025,10.30476/ijms.2025.103065.3620,https://pubmed.ncbi.nlm.nih.gov/40861836/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,40108668,Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer.,2025,10.1186/s12964-025-02139-6,https://pubmed.ncbi.nlm.nih.gov/40108668/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,41153950,Metabolomics Reveals Abnormal Citrate Cycle and Phenylalanine Metabolism in Testes from Infertile Hybrid Dzo.,2025,10.3390/ani15203023,https://pubmed.ncbi.nlm.nih.gov/41153950/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,38654926,Proteomic biomarkers in seminal plasma as predictors of reproductive potential in azoospermic men.,2024,10.3389/fendo.2024.1327800,https://pubmed.ncbi.nlm.nih.gov/38654926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,40681857,Expression of marker genes to assess the spermatogenic capacity in patients with idiopathic non-obstructive azoospermia.,2025,10.1007/s10815-025-03584-5,https://pubmed.ncbi.nlm.nih.gov/40681857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,41153772,Machine Learning-Based Validation of LDHC and SLC35G2 Methylation as Epigenetic Biomarkers for Food Allergy.,2025,10.3390/biomedicines13102489,https://pubmed.ncbi.nlm.nih.gov/41153772/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,39001513,The LDHC-STAT3 Signaling Network Is a Key Regulator of Basal-like Breast Cancer Cell Survival.,2024,10.3390/cancers16132451,https://pubmed.ncbi.nlm.nih.gov/39001513/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,40299647,"Stallion spermatozoa express LDH isoforms A, B, and C, with LDHC playing a crucial role in sustaining sperm viability.",2025,10.1530/rep-24-0436,https://pubmed.ncbi.nlm.nih.gov/40299647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,41895200,Mechanistic insights into novel triclosan target pathways in Neocaridina denticulata revealed by multi-omics integration.,2026,10.1016/j.jhazmat.2026.141856,https://pubmed.ncbi.nlm.nih.gov/41895200/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,40860340,Identification and experimental validation of prognostic genes related to cytochrome c in breast cancer.,2025,10.3389/fgene.2025.1627134,https://pubmed.ncbi.nlm.nih.gov/40860340/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,35693780,Exposed and Sequestered Antigens in Testes and Their Protection by Regulatory T Cell-Dependent Systemic Tolerance.,2022,10.3389/fimmu.2022.809247,https://pubmed.ncbi.nlm.nih.gov/35693780/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,37189204,Tanshinone IIA inhibits osteoclastogenesis in rheumatoid arthritis via LDHC-regulated ROS generation.,2023,10.1186/s13020-023-00765-1,https://pubmed.ncbi.nlm.nih.gov/37189204/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,36041633,MeDIP-seq and RNA-seq analysis during porcine testis development reveals functional DMR at the promoter of LDHC.,2022,10.1016/j.ygeno.2022.110467,https://pubmed.ncbi.nlm.nih.gov/36041633/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,41226485,TFAM Loss Induces Oxidative Stress and Divergent Phenotypes in Glioblastoma Metabolic Subtypes.,2025,10.3390/ijms262110446,https://pubmed.ncbi.nlm.nih.gov/41226485/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,31932876,Identification of two HLA-A*0201 immunogenic epitopes of lactate dehydrogenase C (LDHC): potential novel targets for cancer immunotherapy.,2020,10.1007/s00262-020-02480-4,https://pubmed.ncbi.nlm.nih.gov/31932876/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,35814471,"Cancer-Testis Antigen LDH-C4 in Tissue, Serum, and Serum-Derived Exosomes Serves as a Promising Biomarker in Lung Adenocarcinoma.",2022,10.3389/fonc.2022.912624,https://pubmed.ncbi.nlm.nih.gov/35814471/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,41328241,Proteomic analysis of seminal plasma in Bali-polled bulls: Identifying biomarkers for fertility assessment.,2025,10.5455/javar.2025.l933,https://pubmed.ncbi.nlm.nih.gov/41328241/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,39469458,Genomic insights and functional evaluation of &lt;i&gt;Lacticaseibacillus paracasei&lt;/i&gt; EG005: a promising probiotic with enhanced antioxidant activity.,2024,10.3389/fmicb.2024.1477152,https://pubmed.ncbi.nlm.nih.gov/39469458/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LDHC,ENSG00000166796,CTA,38291366,Systematic analysis of the role of LDHs subtype in pan-cancer demonstrates the importance of LDHD in the prognosis of hepatocellular carcinoma patients.,2024,10.1186/s12885-024-11920-8,https://pubmed.ncbi.nlm.nih.gov/38291366/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,42666350,PLAC8 participates in the prognosis regulation of breast cancer by regulating the infiltration of immune cells in the tumor microenvironment.,2026,10.3389/fbinf.2026.1814907,https://pubmed.ncbi.nlm.nih.gov/42666350/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,41103442,Targeting the CCL28-STAT3-PLAC8 axis to suppress metastasis and remodel tumor microenvironment in colorectal cancer.,2025,10.3389/fimmu.2025.1610540,https://pubmed.ncbi.nlm.nih.gov/41103442/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,42136310,Identification and Experimental Validation of PLAC8 as a Biomarker for Follicular Lymphoma.,2026,10.2174/0109298673412238251209112533,https://pubmed.ncbi.nlm.nih.gov/42136310/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,42516385,Tumor-associated macrophages and lineage plasticity in prostate cancer: from established myeloid programs to emerging spatial hypotheses.,2026,10.3389/fimmu.2026.1853196,https://pubmed.ncbi.nlm.nih.gov/42516385/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,40471391,PLAC8 as a potential therapeutic target for myocardial infarction: unraveling the molecular mechanisms.,2025,10.1007/s13105-025-01098-3,https://pubmed.ncbi.nlm.nih.gov/40471391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,42410766,Bioinformatic identification of genes and mechanisms related to acute respiratory distress syndrome and sepsis: A bioinformatic study.,2026,10.1097/md.0000000000049521,https://pubmed.ncbi.nlm.nih.gov/42410766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,40512859,Interaction between NF-κB and PLAC8 impairs autophagy providing a survival advantage to prostate cells transformed by cadmium.,2025,10.1126/sciadv.adv8640,https://pubmed.ncbi.nlm.nih.gov/40512859/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,42862045,Experimental evidence that dietary antioxidants induce an antiviral transcriptomic signature in a wild seabird.,2026,10.1242/bio.062786,https://pubmed.ncbi.nlm.nih.gov/42862045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,40508180,PLAC8 Expression Regulates Trophoblast Invasion and Conversion into an Endothelial Phenotype (eEVT).,2025,10.3390/ijms26115371,https://pubmed.ncbi.nlm.nih.gov/40508180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,39900678,Host factor PLAC8 is required for pancreas infection by SARS-CoV-2.,2025,10.1038/s43856-025-00745-6,https://pubmed.ncbi.nlm.nih.gov/39900678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,40398706,Aberrant PLAC8 expression characterizes glioblastoma with temozolomide resistance and an immunosuppressive microenvironment.,2025,10.1016/j.canlet.2025.217805,https://pubmed.ncbi.nlm.nih.gov/40398706/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,39917301,Identification and validation of immune and diagnostic biomarkers for interstitial cystitis/painful bladder syndrome by integrating bioinformatics and machine-learning.,2025,10.3389/fimmu.2025.1511529,https://pubmed.ncbi.nlm.nih.gov/39917301/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,42389146,"An evolutionary genomic perspective on preterm birth, genome editing, and pregnancy in the human species.",2026,10.3389/fgeed.2026.1805932,https://pubmed.ncbi.nlm.nih.gov/42389146/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,39810019,PLAC8 attenuates pulmonary fibrosis and inhibits apoptosis of alveolar epithelial cells via facilitating autophagy.,2025,10.1038/s42003-024-07334-8,https://pubmed.ncbi.nlm.nih.gov/39810019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,42628362,The transcription factor SbWRKY6 confers cadmium tolerance via activating SbPLAC8-17 expression in sorghum.,2026,10.1016/j.jhazmat.2026.143333,https://pubmed.ncbi.nlm.nih.gov/42628362/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,42115827,Cost-effective strategies for long-term bovine trophectoderm cell culture.,2026,10.1017/s096719942610046x,https://pubmed.ncbi.nlm.nih.gov/42115827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,38961068,Plac8-ERK pathway modulation of monocyte function in sepsis.,2024,10.1038/s41420-024-02012-4,https://pubmed.ncbi.nlm.nih.gov/38961068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,41940473,The Impact of Melatonin on Cellular Dynamics and Gene Expression of Bovine Embryos Cultured Under Low and High Oxygen Tension.,2026,10.1002/mrd.70102,https://pubmed.ncbi.nlm.nih.gov/41940473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,41092181,"The CELL NUMBER REGULATOR SlFWL5 protein regulates aerial vegetative growth in tomato, by promoting cell expansion.",2026,10.1093/jxb/eraf444,https://pubmed.ncbi.nlm.nih.gov/41092181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,42894123,Integrative BSA-seq and time-course RNA-seq prioritize candidate loci and genes associated with whole-plant cadmium (Cd) accumulation and tolerance in dark jute (Corchorus olitorius L.).,2026,10.1186/s12870-026-09553-z,https://pubmed.ncbi.nlm.nih.gov/42894123/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,41007309,Research Progress on &lt;i&gt;PCR&lt;/i&gt; (Plant Cadmium Resistance) Genes in Plants.,2025,10.3390/biology14091163,https://pubmed.ncbi.nlm.nih.gov/41007309/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,41208844,A Tertiary Lymphoid Structure-Related Gene Signature Predicts Prognosis and Treatment Response in Hepatocellular Carcinoma.,2025,10.14740/wjon2646,https://pubmed.ncbi.nlm.nih.gov/41208844/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,38023190,PLAC8 is an innovative biomarker for immunotherapy participating in remodeling the immune microenvironment of renal clear cell carcinoma.,2023,10.3389/fonc.2023.1207551,https://pubmed.ncbi.nlm.nih.gov/38023190/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,36543379,Modification of PLAC8 by UFM1 affects tumorous proliferation and immune response by impacting PD-L1 levels in triple-negative breast cancer.,2022,10.1136/jitc-2022-005668,https://pubmed.ncbi.nlm.nih.gov/36543379/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,42751151,VCP at the crossroads of UPS and autophagy in cancer.,2027,10.1016/j.gendis.2026.102264,https://pubmed.ncbi.nlm.nih.gov/42751151/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,42075348,Genome-Wide Identification of the &lt;i&gt;FWL&lt;/i&gt; Gene Family in Rice Reveals Critical Roles in Abiotic Stress Response.,2026,10.3390/plants15081146,https://pubmed.ncbi.nlm.nih.gov/42075348/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,40959565,A Machine Learning-Based Hypoxia-Related Gene Signatures to Facilitate Prediction of Cetuximab Response in Patients with Colorectal Cancer.,2025,10.7150/ijms.114833,https://pubmed.ncbi.nlm.nih.gov/40959565/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,37885015,Low m6A modification-mediated upregulation of PLAC8 promotes trophoblast cell invasion and migration in preeclampsia.,2023,10.1186/s40001-023-01442-7,https://pubmed.ncbi.nlm.nih.gov/37885015/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,42385180,Folic Acid Alleviates X-Ray Irradiation-Induced Jaw Malformation in Zebrafish.,2026,10.1002/cga.70069,https://pubmed.ncbi.nlm.nih.gov/42385180/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,38993245,Identification and Validation of a Novel Tertiary Lymphoid Structures-Related Prognostic Gene Signature in Hepatocellular Carcinoma.,2024,10.14740/wjon1893,https://pubmed.ncbi.nlm.nih.gov/38993245/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,38323001,Alleviation of monocyte exhaustion by BCG derivative mycolic acid.,2024,10.1016/j.isci.2024.108978,https://pubmed.ncbi.nlm.nih.gov/38323001/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,39014148,Cellular heterogeneity and key subsets of tissue-resident memory T cells in cervical cancer.,2024,10.1038/s41698-024-00637-3,https://pubmed.ncbi.nlm.nih.gov/39014148/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS13,ENSG00000105198,CTA,19497882,A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death.,2009,10.1073/pnas.0903568106,https://pubmed.ncbi.nlm.nih.gov/19497882/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
LGALS13,ENSG00000105198,CTA,10527825,"Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden Crystal protein.",1999,10.1053/plac.1999.0436,https://pubmed.ncbi.nlm.nih.gov/10527825/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
LGALS14,ENSG00000006659,CTA,42882343,The Least Understood Placental Galectins: Galectin-14 and Galectin-16 in Human Pregnancy and Placental Biology.,2026,10.3390/diagnostics16193188,https://pubmed.ncbi.nlm.nih.gov/42882343/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS14,ENSG00000006659,CTA,35923419,Bioinformatics Analysis Identifies Potential Related Genes in the Pathogenesis of Intrauterine Fetal Growth Retardation.,2022,10.1177/11769343221112780,https://pubmed.ncbi.nlm.nih.gov/35923419/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS14,ENSG00000006659,CTA,33150487,Examining Sex Differences in the Human Placental Transcriptome During the First Fetal Androgen Peak.,2021,10.1007/s43032-020-00355-8,https://pubmed.ncbi.nlm.nih.gov/33150487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS14,ENSG00000006659,CTA,27660926,Altered Biomarkers in Trophoblast Cells Obtained Noninvasively Prior to Clinical Manifestation of Perinatal Disease.,2016,10.1038/srep32382,https://pubmed.ncbi.nlm.nih.gov/27660926/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS14,ENSG00000006659,CTA,26051097,Noninvasive detection of trophoblast protein signatures linked to early pregnancy loss using trophoblast retrieval and isolation from the cervix (TRIC).,2015,10.1016/j.fertnstert.2015.05.010,https://pubmed.ncbi.nlm.nih.gov/26051097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS14,ENSG00000006659,CTA,25437054,Using RNA sequencing for identifying gene imprinting and random monoallelic expression in human placenta.,2014,10.4161/15592294.2014.970052,https://pubmed.ncbi.nlm.nih.gov/25437054/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS14,ENSG00000006659,CTA,27406225,Evaluating genotoxic risks in Brazilian public health agents occupationally exposed to pesticides: a multi-biomarker approach.,2016,10.1007/s11356-016-7179-y,https://pubmed.ncbi.nlm.nih.gov/27406225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS14,ENSG00000006659,CTA,25266889,Evolutionary origins of the placental expression of chromosome 19 cluster galectins and their complex dysregulation in preeclampsia.,2014,10.1016/j.placenta.2014.07.015,https://pubmed.ncbi.nlm.nih.gov/25266889/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS14,ENSG00000006659,CTA,11997112,"Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta(1).",2002,10.1016/s0167-4781(01)00319-0,https://pubmed.ncbi.nlm.nih.gov/11997112/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS14,ENSG00000006659,CTA,19497882,A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death.,2009,10.1073/pnas.0903568106,https://pubmed.ncbi.nlm.nih.gov/19497882/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS16,ENSG00000249861,CTA,42882343,The Least Understood Placental Galectins: Galectin-14 and Galectin-16 in Human Pregnancy and Placental Biology.,2026,10.3390/diagnostics16193188,https://pubmed.ncbi.nlm.nih.gov/42882343/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS16,ENSG00000249861,CTA,38212900,Insights into cAMP-dependent molecular mechanisms regulating expression and function of LGALS16 gene in choriocarcinoma JEG-3 cells.,2024,10.1002/cbin.12128,https://pubmed.ncbi.nlm.nih.gov/38212900/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS16,ENSG00000249861,CTA,34944551,"Expression, Regulation, and Functions of the Galectin-16 Gene in Human Cells and Tissues.",2021,10.3390/biom11121909,https://pubmed.ncbi.nlm.nih.gov/34944551/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS16,ENSG00000249861,CTA,28647356,Optimizing bone morphogenic protein 4-mediated human embryonic stem cell differentiation into trophoblast-like cells using fibroblast growth factor 2 and transforming growth factor-β/activin/nodal signalling inhibition.,2017,10.1016/j.rbmo.2017.06.003,https://pubmed.ncbi.nlm.nih.gov/28647356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS16,ENSG00000249861,CTA,19497882,A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death.,2009,10.1073/pnas.0903568106,https://pubmed.ncbi.nlm.nih.gov/19497882/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LLCFC1,ENSG00000165131,CTA,32393636,"Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice.",2020,10.1073/pnas.1922650117,https://pubmed.ncbi.nlm.nih.gov/32393636/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LLCFC1,ENSG00000165131,CTA,40711049,"Impact of Polystyrene Microplastics on Human Sperm Functionality: An In Vitro Study of Cytotoxicity, Genotoxicity and Fertility-Related Genes Expression.",2025,10.3390/toxics13070605,https://pubmed.ncbi.nlm.nih.gov/40711049/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LLCFC1,ENSG00000165131,CTA,40847515,The chloroplast translocon subunit TOC33 relays singlet oxygen-induced chloroplast-to-nucleus retrograde signaling in Arabidopsis.,2025,10.1016/j.molp.2025.08.013,https://pubmed.ncbi.nlm.nih.gov/40847515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LLCFC1,ENSG00000165131,CTA,40058809,Molecular mechanisms leading to gamete fusion.,2025,10.5387/fms.24-00046,https://pubmed.ncbi.nlm.nih.gov/40058809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LLCFC1,ENSG00000165131,CTA,37452197,Inactivation of poly(3-hydroxybutyrate) (PHB) biosynthesis in 'Knallgas' bacterium Xanthobacter sp. SoF1.,2023,10.1186/s13568-023-01577-0,https://pubmed.ncbi.nlm.nih.gov/37452197/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LLCFC1,ENSG00000165131,CTA,37453427,"SPE-51, a sperm-secreted protein with an immunoglobulin-like domain, is required for fertilization in C. elegans.",2023,10.1016/j.cub.2023.06.029,https://pubmed.ncbi.nlm.nih.gov/37453427/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LLCFC1,ENSG00000165131,CTA,37453426,The EGF-motif-containing protein SPE-36 is a secreted sperm protein required for fertilization in C. elegans.,2023,10.1016/j.cub.2023.06.051,https://pubmed.ncbi.nlm.nih.gov/37453426/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LLCFC1,ENSG00000165131,CTA,35096839,Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats.,2021,10.3389/fcell.2021.810118,https://pubmed.ncbi.nlm.nih.gov/35096839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LLCFC1,ENSG00000165131,CTA,37080410,Analyzing the effect of heparin on in vitro capacitation and spermatozoal RNA population in goats.,2023,10.1016/j.ijbiomac.2023.124502,https://pubmed.ncbi.nlm.nih.gov/37080410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LLCFC1,ENSG00000165131,CTA,26194883,Contrasting effects of G1.2/G2.2 and SOF1/SOF2 embryo culture media on pre- and post-implantation development of non-transgenic and transgenic cloned goat embryos.,2015,10.1016/j.rbmo.2015.06.008,https://pubmed.ncbi.nlm.nih.gov/26194883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LLCFC1,ENSG00000165131,CTA,31681433,Exome Sequencing in &lt;i&gt;BRCA1-&lt;/i&gt; and &lt;i&gt;BRCA2&lt;/i&gt;-Negative Greek Families Identifies &lt;i&gt;MDM1&lt;/i&gt; and &lt;i&gt;NBEAL1&lt;/i&gt; as Candidate Risk Genes for Hereditary Breast Cancer.,2019,10.3389/fgene.2019.01005,https://pubmed.ncbi.nlm.nih.gov/31681433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LLCFC1,ENSG00000165131,CTA,15457517,Species-related differences in blastocyst quality are associated with differences in relative mRNA transcription.,2004,10.1002/mrd.20133,https://pubmed.ncbi.nlm.nih.gov/15457517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LLCFC1,ENSG00000165131,CTA,8508778,A U3 snoRNP protein with homology to splicing factor PRP4 and G beta domains is required for ribosomal RNA processing.,1993,10.1002/j.1460-2075.1993.tb05910.x,https://pubmed.ncbi.nlm.nih.gov/8508778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LLCFC1,ENSG00000165131,CTA,17219429,Temporal expression of transcripts related to embryo quality in bovine embryos cultured from the two-cell to blastocyst stage in vitro or in vivo.,2007,10.1002/mrd.20677,https://pubmed.ncbi.nlm.nih.gov/17219429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LLCFC1,ENSG00000165131,CTA,41782075,In vivo mammalian micronucleus test in mice confirms lack of genotoxic potential of a protein-rich powder derived from Xanthobacter sp. SoF1.,2026,10.1186/s41021-026-00356-0,https://pubmed.ncbi.nlm.nih.gov/41782075/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LLCFC1,ENSG00000165131,CTA,39098047,90-day oral toxicity study in rats of a protein-rich powder derived from Xanthobacter sp. SoF1.,2024,10.1002/jat.4663,https://pubmed.ncbi.nlm.nih.gov/39098047/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LLCFC1,ENSG00000165131,CTA,38730487,In vitro genotoxicological evaluation of protein-rich powder derived from Xanthobacter sp. SoF1.,2024,10.1002/jat.4621,https://pubmed.ncbi.nlm.nih.gov/38730487/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRD1,ENSG00000240720,CTA,38697008,Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice.,2024,10.1016/j.jri.2024.104252,https://pubmed.ncbi.nlm.nih.gov/38697008/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRD1,ENSG00000240720,CTA,36483096,MET gene alterations predict poor survival following chemotherapy in patients with advanced cancer.,2022,10.3389/pore.2022.1610697,https://pubmed.ncbi.nlm.nih.gov/36483096/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRD1,ENSG00000240720,CTA,34761221,CSF-resident CD4&lt;sup&gt;+&lt;/sup&gt; T-cells display a distinct gene expression profile with relevance to immune surveillance and multiple sclerosis.,2021,10.1093/braincomms/fcab155,https://pubmed.ncbi.nlm.nih.gov/34761221/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LUZP4,ENSG00000102021,CTA,41922334,Whole-proteome phage immunoprecipitation sequencing reveals germ cell tumor-specific immunosignature.,2026,10.1038/s41467-026-71174-9,https://pubmed.ncbi.nlm.nih.gov/41922334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LUZP4,ENSG00000102021,CTA,42710022,"Paraneoplastic neurological syndromes: an update on incidence, antibody discovery, and testing.",2026,10.1097/cco.0000000000001268,https://pubmed.ncbi.nlm.nih.gov/42710022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LUZP4,ENSG00000102021,CTA,40099632,Paraneoplastic Leucine Zipper 4 IgG Associated Motor-Predominant Polyradiculoneuropathy.,2025,10.1111/jns.70013,https://pubmed.ncbi.nlm.nih.gov/40099632/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LUZP4,ENSG00000102021,CTA,36446526,Transcriptome analyses in infertile men reveal germ cell-specific expression and splicing patterns.,2023,10.26508/lsa.202201633,https://pubmed.ncbi.nlm.nih.gov/36446526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LUZP4,ENSG00000102021,CTA,33583072,Leucine Zipper 4 Autoantibody: A Novel Germ Cell Tumor and Paraneoplastic Biomarker.,2021,10.1002/ana.26050,https://pubmed.ncbi.nlm.nih.gov/33583072/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LUZP4,ENSG00000102021,CTA,34745199,Placental Gene Co-expression Network for Maternal Plasma Lipids Revealed Enrichment of Inflammatory Response Pathways.,2021,10.3389/fgene.2021.681095,https://pubmed.ncbi.nlm.nih.gov/34745199/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LUZP4,ENSG00000102021,CTA,25662211,Luzp4 defines a new mRNA export pathway in cancer cells.,2015,10.1093/nar/gkv070,https://pubmed.ncbi.nlm.nih.gov/25662211/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LUZP4,ENSG00000102021,CTA,24889268,High throughput quantitative reverse transcription PCR assays revealing over-expression of cancer testis antigen genes in multiple myeloma stem cell-like side population cells.,2014,10.1111/bjh.12951,https://pubmed.ncbi.nlm.nih.gov/24889268/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LUZP4,ENSG00000102021,CTA,34080453,RNA Binding Protein-Based Model for Prognostic Prediction of Colorectal Cancer.,2021,10.1177/15330338211019504,https://pubmed.ncbi.nlm.nih.gov/34080453/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LUZP4,ENSG00000102021,CTA,30378261,Exome sequencing of sporadic childhood-onset schizophrenia suggests the contribution of X-linked genes in males.,2019,10.1002/ajmg.b.32683,https://pubmed.ncbi.nlm.nih.gov/30378261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LUZP4,ENSG00000102021,CTA,27920729,Transcriptional Network Architecture of Breast Cancer Molecular Subtypes.,2016,10.3389/fphys.2016.00568,https://pubmed.ncbi.nlm.nih.gov/27920729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LUZP4,ENSG00000102021,CTA,38772930,Clinical and serological insights into paraneoplastic brachial amyotrophic diplegia.,2024,10.1007/s00415-024-12425-x,https://pubmed.ncbi.nlm.nih.gov/38772930/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LUZP4,ENSG00000102021,CTA,34937736,Population-Based Epidemiology Study of Paraneoplastic Neurologic Syndromes.,2022,10.1212/nxi.0000000000001124,https://pubmed.ncbi.nlm.nih.gov/34937736/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LUZP4,ENSG00000102021,CTA,12032826,A novel tumour associated leucine zipper protein targeting to sites of gene transcription and splicing.,2002,10.1038/sj.onc.1205481,https://pubmed.ncbi.nlm.nih.gov/12032826/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYPD4,ENSG00000273111,CTA,40962834,GALNTL5 binds GalNAc and is required for migration through the uterotubal junction and sperm-zona pellucida binding.,2025,10.1038/s41467-025-63805-4,https://pubmed.ncbi.nlm.nih.gov/40962834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYPD4,ENSG00000273111,CTA,38034362,A common single nucleotide polymorphism is associated with inflammation and critical illness outcomes.,2023,10.1016/j.isci.2023.108333,https://pubmed.ncbi.nlm.nih.gov/38034362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYPD4,ENSG00000273111,CTA,39112778,A meta-analysis of genome-wide studies of resilience in the German population.,2025,10.1038/s41380-024-02688-1,https://pubmed.ncbi.nlm.nih.gov/39112778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYPD4,ENSG00000273111,CTA,41280419,Proteomic and functional analysis of alpaca (&lt;i&gt;Vicugna pacos&lt;/i&gt;) sperm quality following &lt;i&gt;in vitro&lt;/i&gt; capacitation with follicular and oviductal fluids.,2025,10.3389/fvets.2025.1702095,https://pubmed.ncbi.nlm.nih.gov/41280419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYPD4,ENSG00000273111,CTA,32040177,"LYPD4, mouse homolog of a human acrosome protein, is essential for sperm fertilizing ability and male fertility†.",2020,10.1093/biolre/ioaa018,https://pubmed.ncbi.nlm.nih.gov/32040177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYPD4,ENSG00000273111,CTA,31455729,Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice.,2019,10.1073/pnas.1908736116,https://pubmed.ncbi.nlm.nih.gov/31455729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL1,ENSG00000120563,CTA,27611690,In Silico and Biochemical Characterization of Lysozyme-Like Proteins in the Rat.,2016,10.1371/journal.pone.0161909,https://pubmed.ncbi.nlm.nih.gov/27611690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL1,ENSG00000120563,CTA,31183516,Cloning and Analysis of Genes Controlling Antibacterial Activities of Burkholderia pyrrocinia Strain Lyc2.,2019,10.1007/s00284-019-01690-z,https://pubmed.ncbi.nlm.nih.gov/31183516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL1,ENSG00000120563,CTA,32730854,Fish lysozyme gene family evolution and divergent function in early development.,2021,10.1016/j.dci.2020.103772,https://pubmed.ncbi.nlm.nih.gov/32730854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL1,ENSG00000120563,CTA,33436510,Associations of Genetic Variants Contributing to Gut Microbiota Composition in Immunoglobin A Nephropathy.,2021,10.1128/msystems.00819-20,https://pubmed.ncbi.nlm.nih.gov/33436510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL1,ENSG00000120563,CTA,35336983,Molecular Characteristics and Incidence of Apple Rubbery Wood Virus 2 and Citrus Virus A Infecting Pear Trees in China.,2022,10.3390/v14030576,https://pubmed.ncbi.nlm.nih.gov/35336983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL1,ENSG00000120563,CTA,32093221,"Long-Term Oral Administration of LLHK, LHK, and HK Alters Gene Expression Profile and Restores Age-Dependent Atrophy and Dysfunction of Rat Salivary Glands.",2020,10.3390/biomedicines8020038,https://pubmed.ncbi.nlm.nih.gov/32093221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL1,ENSG00000120563,CTA,24013621,Characterisation of Lyzls in mice and antibacterial properties of human LYZL6.,2013,10.1038/aja.2013.93,https://pubmed.ncbi.nlm.nih.gov/24013621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL1,ENSG00000120563,CTA,22110709,Characterization of a novel lysozyme-like 4 gene in the rat.,2011,10.1371/journal.pone.0027659,https://pubmed.ncbi.nlm.nih.gov/22110709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL1,ENSG00000120563,CTA,31424156,Proteomic Analysis of Dpy19l2-Deficient Human Globozoospermia Reveals Multiple Molecular Defects.,2019,10.1002/prca.201900007,https://pubmed.ncbi.nlm.nih.gov/31424156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL1,ENSG00000120563,CTA,33370338,The role of the MAD2-TLR4-MyD88 axis in paclitaxel resistance in ovarian cancer.,2020,10.1371/journal.pone.0243715,https://pubmed.ncbi.nlm.nih.gov/33370338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL1,ENSG00000120563,CTA,1090662,Thymic regeneration after lethal irradiation evidence for an intra-thymic radioresistant T cell precursor.,1975,10.4049/jimmunol.114.1_part_2.452,https://pubmed.ncbi.nlm.nih.gov/1090662/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL2,ENSG00000151033,CTA,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL2,ENSG00000151033,CTA,27832206,"Structural, Functional and Phylogenetic Analysis of Sperm Lysozyme-Like Proteins.",2016,10.1371/journal.pone.0166321,https://pubmed.ncbi.nlm.nih.gov/27832206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL2,ENSG00000151033,CTA,16014814,"Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family.",2005,10.1095/biolreprod.105.041889,https://pubmed.ncbi.nlm.nih.gov/16014814/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL2,ENSG00000151033,CTA,24702466,Clinical application of genetics to guide prevention and treatment of oral diseases.,2014,10.1111/cge.12396,https://pubmed.ncbi.nlm.nih.gov/24702466/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL2,ENSG00000151033,CTA,23064961,GWAS of dental caries patterns in the permanent dentition.,2013,10.1177/0022034512463579,https://pubmed.ncbi.nlm.nih.gov/23064961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL4,ENSG00000157093,CTA,39555667,Microglial Lyzl4 Facilitates β-Amyloid Clearance in Alzheimer's Disease.,2025,10.1002/advs.202412184,https://pubmed.ncbi.nlm.nih.gov/39555667/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL4,ENSG00000157093,CTA,38669244,"Age-dependent changes in the expression and localization of LYZL4, LYZL6 and PCNA during testicular development in the Ashidan yak.",2024,10.1080/10495398.2024.2344213,https://pubmed.ncbi.nlm.nih.gov/38669244/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL4,ENSG00000157093,CTA,37118964,Differential Proteomic Analysis of Human Sperm: A Systematic Review to Identify Candidate Targets to Monitor Sperm Quality.,2024,10.5534/wjmh.220262,https://pubmed.ncbi.nlm.nih.gov/37118964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL4,ENSG00000157093,CTA,37600190,Leaf resistance to Botrytis cinerea in wild tomato Solanum habrochaites depends on inoculum composition.,2023,10.3389/fpls.2023.1156804,https://pubmed.ncbi.nlm.nih.gov/37600190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL4,ENSG00000157093,CTA,29658230,[Preparation of a polyclonal antibody against human LYZL4 and its expression in the testis].,2017,,https://pubmed.ncbi.nlm.nih.gov/29658230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL4,ENSG00000157093,CTA,30156068,[The role of human lysozyme-like protein 4 in fertilization and its enzymatic properties].,2018,,https://pubmed.ncbi.nlm.nih.gov/30156068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL4,ENSG00000157093,CTA,27611690,In Silico and Biochemical Characterization of Lysozyme-Like Proteins in the Rat.,2016,10.1371/journal.pone.0161909,https://pubmed.ncbi.nlm.nih.gov/27611690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL4,ENSG00000157093,CTA,28182716,"LYZL6, an acidic, bacteriolytic, human sperm-related protein, plays a role in fertilization.",2017,10.1371/journal.pone.0171452,https://pubmed.ncbi.nlm.nih.gov/28182716/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL4,ENSG00000157093,CTA,22110709,Characterization of a novel lysozyme-like 4 gene in the rat.,2011,10.1371/journal.pone.0027659,https://pubmed.ncbi.nlm.nih.gov/22110709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL4,ENSG00000157093,CTA,27832206,"Structural, Functional and Phylogenetic Analysis of Sperm Lysozyme-Like Proteins.",2016,10.1371/journal.pone.0166321,https://pubmed.ncbi.nlm.nih.gov/27832206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL4,ENSG00000157093,CTA,24013621,Characterisation of Lyzls in mice and antibacterial properties of human LYZL6.,2013,10.1038/aja.2013.93,https://pubmed.ncbi.nlm.nih.gov/24013621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL4,ENSG00000157093,CTA,21444326,"Lyzl4, a novel mouse sperm-related protein, is involved in fertilization.",2011,10.1093/abbs/gmr017,https://pubmed.ncbi.nlm.nih.gov/21444326/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL4,ENSG00000157093,CTA,29610366,Exome chip analyses identify genes affecting mortality after HLA-matched unrelated-donor blood and marrow transplantation.,2018,10.1182/blood-2017-11-817973,https://pubmed.ncbi.nlm.nih.gov/29610366/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL4,ENSG00000157093,CTA,16014814,"Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family.",2005,10.1095/biolreprod.105.041889,https://pubmed.ncbi.nlm.nih.gov/16014814/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL4,ENSG00000157093,CTA,17273845,The construction of a Solanum habrochaites LYC4 introgression line population and the identification of QTLs for resistance to Botrytis cinerea.,2007,10.1007/s00122-006-0500-2,https://pubmed.ncbi.nlm.nih.gov/17273845/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL6,ENSG00000275722,CTA,38669244,"Age-dependent changes in the expression and localization of LYZL4, LYZL6 and PCNA during testicular development in the Ashidan yak.",2024,10.1080/10495398.2024.2344213,https://pubmed.ncbi.nlm.nih.gov/38669244/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL6,ENSG00000275722,CTA,38605742,"Recombinant Production of TP4-LYC1, A New Chimeric Peptide with Targeted Cytotoxicity to HeLa Cells.",2024,10.18502/ajmb.v16i1.14166,https://pubmed.ncbi.nlm.nih.gov/38605742/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL6,ENSG00000275722,CTA,35627192,Cancer-Testis Gene Biomarkers Discovered in Colon Cancer Patients.,2022,10.3390/genes13050807,https://pubmed.ncbi.nlm.nih.gov/35627192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL6,ENSG00000275722,CTA,36355490,The Expression Patterns of Human Cancer-Testis Genes Are Induced through Epigenetic Drugs in Colon Cancer Cells.,2022,10.3390/ph15111319,https://pubmed.ncbi.nlm.nih.gov/36355490/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL6,ENSG00000275722,CTA,28182716,"LYZL6, an acidic, bacteriolytic, human sperm-related protein, plays a role in fertilization.",2017,10.1371/journal.pone.0171452,https://pubmed.ncbi.nlm.nih.gov/28182716/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL6,ENSG00000275722,CTA,28965373,[Expression of human lysozyme-like protein 6 in the male reproductive system].,2016,,https://pubmed.ncbi.nlm.nih.gov/28965373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL6,ENSG00000275722,CTA,37549510,Integrated molecular-network analysis reveals infertility-associated key genes and transcription factors in the non-obstructive azoospermia.,2023,10.1016/j.ejogrb.2023.07.023,https://pubmed.ncbi.nlm.nih.gov/37549510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL6,ENSG00000275722,CTA,24013621,Characterisation of Lyzls in mice and antibacterial properties of human LYZL6.,2013,10.1038/aja.2013.93,https://pubmed.ncbi.nlm.nih.gov/24013621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL6,ENSG00000275722,CTA,27611690,In Silico and Biochemical Characterization of Lysozyme-Like Proteins in the Rat.,2016,10.1371/journal.pone.0161909,https://pubmed.ncbi.nlm.nih.gov/27611690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL6,ENSG00000275722,CTA,31479777,Identifying candidate genes associated with sperm morphology abnormalities using weighted single-step GWAS in a Duroc boar population.,2020,10.1016/j.theriogenology.2019.08.031,https://pubmed.ncbi.nlm.nih.gov/31479777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL6,ENSG00000275722,CTA,27832206,"Structural, Functional and Phylogenetic Analysis of Sperm Lysozyme-Like Proteins.",2016,10.1371/journal.pone.0166321,https://pubmed.ncbi.nlm.nih.gov/27832206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL6,ENSG00000275722,CTA,22110709,Characterization of a novel lysozyme-like 4 gene in the rat.,2011,10.1371/journal.pone.0027659,https://pubmed.ncbi.nlm.nih.gov/22110709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL6,ENSG00000275722,CTA,24745549,"Production of LYZL6, a novel human c-type lysozyme, in recombinant Pichia pastoris employing high cell density fed-batch fermentation.",2014,10.1016/j.jbiosc.2014.03.009,https://pubmed.ncbi.nlm.nih.gov/24745549/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL6,ENSG00000275722,CTA,24767999,Pkd1 regulates lymphatic vascular morphogenesis during development.,2014,10.1016/j.celrep.2014.03.063,https://pubmed.ncbi.nlm.nih.gov/24767999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL6,ENSG00000275722,CTA,16014814,"Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family.",2005,10.1095/biolreprod.105.041889,https://pubmed.ncbi.nlm.nih.gov/16014814/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL6,ENSG00000275722,CTA,8082161,LYC1 is the structural gene for lysine N-6-acetyl transferase in yeast.,1994,10.1007/bf00712962,https://pubmed.ncbi.nlm.nih.gov/8082161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL6,ENSG00000275722,CTA,24177954,Evidence for the control of a mutation in lysine catabolism by the mating type in Yarrowia lipolytica.,1984,10.1007/bf00410440,https://pubmed.ncbi.nlm.nih.gov/24177954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LYZL6,ENSG00000275722,CTA,19330909,Collagen antibody-induced arthritis in mice: development of a new arthritogenic 5-clone cocktail of monoclonal anti-type II collagen antibodies.,2009,10.1016/j.jim.2009.01.009,https://pubmed.ncbi.nlm.nih.gov/19330909/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,42572086,MAGEA1 drives tumor progression via activation of the AKT pathway and correlates with elevated radiosensitivity in lung adenocarcinoma.,2026,10.1007/s10735-026-10931-y,https://pubmed.ncbi.nlm.nih.gov/42572086/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,42251611,Hypomethylation of FAM83A in lung adenocarcinoma mirrors an epigenetic signature of airway cell differentiation states.,2026,10.1007/s12672-026-05380-8,https://pubmed.ncbi.nlm.nih.gov/42251611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,41823529,Therapeutic implications of targeting cancer testis antigen MAGEA1 in cervical cancer.,2026,10.3892/ijo.2026.5870,https://pubmed.ncbi.nlm.nih.gov/41823529/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,42500564,The Construction and Preclinical Evaluation of Antitumor Activity of a Novel MIgG-OXA ADC in Lung Adenocarcinoma.,2026,10.32604/or.2026.080413,https://pubmed.ncbi.nlm.nih.gov/42500564/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,41566414,Melanoma antigen genes A1 and A3 as predictors of treatment response and survival in HCV-associated hepatocellular carcinoma: a prospective study.,2026,10.1186/s12876-025-04574-8,https://pubmed.ncbi.nlm.nih.gov/41566414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,40395161,"Correction to ""Expression of Cancer-Testis Antigens MAGE-A1, MAGE-A4, NY-ESO-1 and PRAME in Bone and Soft Tissue Sarcomas: The Experience From a Single Center in China"".",2025,10.1002/cam4.70971,https://pubmed.ncbi.nlm.nih.gov/40395161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,40152485,"Expression of Cancer-Testis Antigens MAGE-A1, MAGE-A4, NY-ESO-1 and PRAME in Bone and Soft Tissue Sarcomas: The Experience From a Single Center in China.",2025,10.1002/cam4.70750,https://pubmed.ncbi.nlm.nih.gov/40152485/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,42604673,Targeting the β&lt;sub&gt;2&lt;/sub&gt;-adrenergic receptor suppresses melanoma progression by disrupting the PKA-SOX10-MAGEA1 oncogenic axis.,2026,10.1016/j.bcp.2026.118368,https://pubmed.ncbi.nlm.nih.gov/42604673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,41843279,Comprehensively exploring the roles of MAGEA1 in cryptorchidism and its related transcription factor regulatory network.,2026,10.1007/s10735-026-10767-6,https://pubmed.ncbi.nlm.nih.gov/41843279/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,42169884,Molecular subtyping and prognostic model construction based on endosome-related genes in colorectal cancer.,2026,10.21037/jgo-2025-593,https://pubmed.ncbi.nlm.nih.gov/42169884/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,40791813,DNA-demethylation by DAC induces &lt;i&gt;MAGE&lt;/i&gt; expression and MAGE-specific T cell reactivity against tumors but also healthy cell subsets.,2025,10.1016/j.omton.2025.201018,https://pubmed.ncbi.nlm.nih.gov/40791813/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,39279443,A phase I study of MAGE-A1-targeted T1367 T-cell receptorbased cell therapy in patients with advanced multiple myeloma.,2025,10.3324/haematol.2024.286124,https://pubmed.ncbi.nlm.nih.gov/39279443/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,39864021,"A panel of cancer testis antigens in squamous cell carcinoma of the lung, head and neck, and esophagus: implication for biomarkers and therapeutic targets.",2025,10.1007/s12672-025-01804-z,https://pubmed.ncbi.nlm.nih.gov/39864021/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,39038917,First-in-human dose escalation trial to evaluate the clinical safety and efficacy of an anti-MAGEA1 autologous TCR-transgenic T cell therapy in relapsed and refractory solid tumors.,2024,10.1136/jitc-2023-008668,https://pubmed.ncbi.nlm.nih.gov/39038917/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,37927813,Expression Pattern of Tumor-associated Antigens in Neuroblastoma: Association With Cytogenetic Features and Survival.,2023,10.21873/cdp.10274,https://pubmed.ncbi.nlm.nih.gov/37927813/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,38285780,Expression of MAGE A1 to MAGE A10 in the Forceps Biopsy and Bronchoalveolar Lavage Specimens from Patients with the Central Lung Tumor.,2024,10.31557/apjcp.2024.25.1.159,https://pubmed.ncbi.nlm.nih.gov/38285780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,41484084,A CD8αβ co-receptor modified to contain an intracellular CD28 signaling tail enhances TCR-engineered T cell function independent of solid-tumor-associated co-stimulatory ligands.,2026,10.1038/s41467-025-67446-5,https://pubmed.ncbi.nlm.nih.gov/41484084/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,41142941,Longitudinal monitoring of autoantibody dynamics in patients with early-stage non-small-cell lung cancer undergoing surgery.,2025,10.1515/biol-2025-1133,https://pubmed.ncbi.nlm.nih.gov/41142941/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,39716999,MLLT3 Regulates Melanoma Stemness and Progression by Inhibiting HMGB1 Nuclear Entry and MAGEA1 M5C Modification.,2025,10.1002/advs.202408529,https://pubmed.ncbi.nlm.nih.gov/39716999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,39744640,Diagnostic value of multi-tumor-associated autoantibody expression in esophageal squamous cell carcinoma and correlation of clinical features.,2024,10.3389/fimmu.2024.1518431,https://pubmed.ncbi.nlm.nih.gov/39744640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,40442309,A virus based vaccine combined with IL12 gene therapy eradicates aggressive melanoma.,2025,10.1038/s41598-025-04026-z,https://pubmed.ncbi.nlm.nih.gov/40442309/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,38400008,An Engineered M13 Filamentous Nanoparticle as an Antigen Carrier for a Malignant Melanoma Immunotherapeutic Strategy.,2024,10.3390/v16020232,https://pubmed.ncbi.nlm.nih.gov/38400008/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,39642980,Construction and characterization of a novel secreted MsC-CAR-T cell in solid tumors.,2025,10.1016/j.canlet.2024.217382,https://pubmed.ncbi.nlm.nih.gov/39642980/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,38114231,Autologous engineered T cell receptor therapy in advanced cancer.,2023,10.1080/21645515.2023.2290356,https://pubmed.ncbi.nlm.nih.gov/38114231/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,38371523,"Designing, cloning and simulation studies of cancer/testis antigens based multi-epitope vaccine candidates against cutaneous melanoma: An immunoinformatics approach.",2024,10.1016/j.bbrep.2024.101651,https://pubmed.ncbi.nlm.nih.gov/38371523/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,39704015,Evaluation of MAGE-A4 expression in breast cancer and its impact on prognosis.,2025,10.1111/cas.16433,https://pubmed.ncbi.nlm.nih.gov/39704015/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,42825038,Comparative diagnostic value of a blood-based three-gene DNA methylation assay and a seven-autoantibody panel for differentiating pulmonary nodules.,2026,10.1016/j.jlb.2026.100498,https://pubmed.ncbi.nlm.nih.gov/42825038/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,41397585,"Phage therapy in cancer treatment: Mechanisms, emerging innovations, and translational progress.",2026,10.1016/j.critrevonc.2025.105085,https://pubmed.ncbi.nlm.nih.gov/41397585/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA1,ENSG00000198681,CTA,36016136,Peptide-Based Vaccines in Clinical Phases and New Potential Therapeutic Targets as a New Approach for Breast Cancer: A Review.,2022,10.3390/vaccines10081249,https://pubmed.ncbi.nlm.nih.gov/36016136/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,40890425,Comprehensive analysis of MAGE-A10 in pan-cancer and its validation in gastric cancer.,2025,10.1038/s41598-025-17987-y,https://pubmed.ncbi.nlm.nih.gov/40890425/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,41489697,Serum cancer testis antigen MAGEA3-IgG serves as a diagnostic biomarker in lung adenocarcinoma.,2026,10.1007/s12094-025-04173-9,https://pubmed.ncbi.nlm.nih.gov/41489697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,41060806,A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases.,2025,10.1016/j.celrep.2025.116408,https://pubmed.ncbi.nlm.nih.gov/41060806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,40379175,Identification of MAGE-A10 specific T cell receptor promising in immunotherapy of hepatocellular carcinoma.,2025,10.1016/j.ijbiomac.2025.144243,https://pubmed.ncbi.nlm.nih.gov/40379175/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,39864021,"A panel of cancer testis antigens in squamous cell carcinoma of the lung, head and neck, and esophagus: implication for biomarkers and therapeutic targets.",2025,10.1007/s12672-025-01804-z,https://pubmed.ncbi.nlm.nih.gov/39864021/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,38285780,Expression of MAGE A1 to MAGE A10 in the Forceps Biopsy and Bronchoalveolar Lavage Specimens from Patients with the Central Lung Tumor.,2024,10.31557/apjcp.2024.25.1.159,https://pubmed.ncbi.nlm.nih.gov/38285780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,37835391,MAGE-A10 Protein Expression in Advanced High Grade Serous Ovarian Cancer Is Associated with Resistance to First-Line Platinum-Based Chemotherapy.,2023,10.3390/cancers15194697,https://pubmed.ncbi.nlm.nih.gov/37835391/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,41593295,T-cell receptor clonotypic diversity and specialization in digestive system cancers.,2026,10.1038/s41698-026-01294-4,https://pubmed.ncbi.nlm.nih.gov/41593295/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,39082035,Expression pattern analysis of the MAGE family genes in breast cancer patients and hypomethylation activation in the MCF-7 cells.,2024,10.1016/j.heliyon.2024.e34506,https://pubmed.ncbi.nlm.nih.gov/39082035/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,39224047,Brief Communication on MAGE-A4 and Coexpression of Cancer Testis Antigens in Metastatic Synovial Sarcomas: Considerations for Development of Immunotherapeutics.,2025,10.1097/cji.0000000000000541,https://pubmed.ncbi.nlm.nih.gov/39224047/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,38136576,"How the Intrinsically Disordered N-Terminus of Cancer/Testis Antigen MAGEA10 Is Responsible for Its Expression, Nuclear Localisation and Aberrant Migration.",2023,10.3390/biom13121704,https://pubmed.ncbi.nlm.nih.gov/38136576/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,38450186,Humoral immunoprofiling identifies novel biomarkers and an immune suppressive autoantibody phenotype at the site of disease in pancreatic ductal adenocarcinoma.,2024,10.3389/fonc.2024.1330419,https://pubmed.ncbi.nlm.nih.gov/38450186/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,41127787,Multifunctional HBc Virus-Like Particles Reprogram Immunosuppressive Macrophages and Potentiate CD8&lt;sup&gt;+&lt;/sup&gt; T Cell Responses for Enhanced Cancer Immunotherapy.,2025,10.2147/ijn.s548334,https://pubmed.ncbi.nlm.nih.gov/41127787/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,35851311,Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy.,2022,10.1136/jitc-2022-004600,https://pubmed.ncbi.nlm.nih.gov/35851311/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,35117468,5-aza-2'-deoxycytidine (DAC) treatment induces the MAGE-A10 expression and improves the cytotoxicity of MAGE-A10-specific CTLs in lung cancer cells.,2020,10.21037/tcr.2020.01.10,https://pubmed.ncbi.nlm.nih.gov/35117468/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,35372008,"Phase 1 Clinical Trial Evaluating the Safety and Anti-Tumor Activity of ADP-A2M10 SPEAR T-Cells in Patients With MAGE-A10+ Head and Neck, Melanoma, or Urothelial Tumors.",2022,10.3389/fonc.2022.818679,https://pubmed.ncbi.nlm.nih.gov/35372008/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,39283078,HCMV detection in Asian gastric cancer RNA-seq data sets and clinical validation in Indian GC patients reveals the HCMV-GC specific gene signatures.,2024,10.1128/msystems.00673-24,https://pubmed.ncbi.nlm.nih.gov/39283078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,35086946,Phase I clinical trial evaluating the safety and efficacy of ADP-A2M10 SPEAR T cells in patients with MAGE-A10+ advanced non-small cell lung cancer.,2022,10.1136/jitc-2021-003581,https://pubmed.ncbi.nlm.nih.gov/35086946/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,37814317,Immunization with a multi-antigen targeted DNA vaccine eliminates chemoresistant pancreatic cancer by disrupting tumor-stromal cell crosstalk.,2023,10.1186/s12967-023-04519-3,https://pubmed.ncbi.nlm.nih.gov/37814317/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,37866309,Diagnostic performance of anti-MAGEA family protein autoantibodies in esophageal squamous cell carcinoma.,2023,10.1016/j.intimp.2023.111041,https://pubmed.ncbi.nlm.nih.gov/37866309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,36171007,Correction: Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy.,2022,10.1136/jitc-2022-004600corr1,https://pubmed.ncbi.nlm.nih.gov/36171007/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,34413169,Phase I/II trial of a long peptide vaccine (LPV7) plus toll-like receptor (TLR) agonists with or without incomplete Freund's adjuvant (IFA) for resected high-risk melanoma.,2021,10.1136/jitc-2021-003220,https://pubmed.ncbi.nlm.nih.gov/34413169/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,32965606,MAGEA10 expression is a predictive marker of early hepatic recurrence after curative gastrectomy for gastric and gastroesophageal junction cancer.,2021,10.1007/s10120-020-01123-y,https://pubmed.ncbi.nlm.nih.gov/32965606/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,30713784,Affinity-enhanced T-cell receptors for adoptive T-cell therapy targeting MAGE-A10: strategy for selection of an optimal candidate.,2019,10.1080/2162402x.2018.1532759,https://pubmed.ncbi.nlm.nih.gov/30713784/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,26191258,Predictive and prognostic effect of CD133 and cancer-testis antigens in stage Ib-IIIA non-small cell lung cancer.,2015,,https://pubmed.ncbi.nlm.nih.gov/26191258/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA10,ENSG00000124260,CTA,21710496,"MAGE-A10 is a nuclear protein frequently expressed in high percentages of tumor cells in lung, skin and urothelial malignancies.",2011,10.1002/ijc.25777,https://pubmed.ncbi.nlm.nih.gov/21710496/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,41272195,"MAGEA11 promotes GC proliferation, migration, and invasion through activation of E2F1 transcriptional activity.",2025,10.1038/s41598-025-25392-8,https://pubmed.ncbi.nlm.nih.gov/41272195/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,42602890,Investigation and validation of prognostic features associated with transient receptor potential channel genes in gastric cancer.,2026,10.7717/peerj.21468,https://pubmed.ncbi.nlm.nih.gov/42602890/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,41631009,Efferocytosis-associated transcriptomic patterns characterize prognosis and immune landscape in osteosarcoma.,2026,10.1016/j.jbo.2026.100743,https://pubmed.ncbi.nlm.nih.gov/41631009/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,41489697,Serum cancer testis antigen MAGEA3-IgG serves as a diagnostic biomarker in lung adenocarcinoma.,2026,10.1007/s12094-025-04173-9,https://pubmed.ncbi.nlm.nih.gov/41489697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,38180746,MAGE-A11 is a potential prognostic biomarker and immunotherapeutic target in gastric cancer.,2024,10.18632/aging.205368,https://pubmed.ncbi.nlm.nih.gov/38180746/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,39864021,"A panel of cancer testis antigens in squamous cell carcinoma of the lung, head and neck, and esophagus: implication for biomarkers and therapeutic targets.",2025,10.1007/s12672-025-01804-z,https://pubmed.ncbi.nlm.nih.gov/39864021/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,40400969,"Construction of a multigenic diagnostic, prognostic, and immune infiltration model with methylation-associated regulators in esophageal squamous cell carcinoma.",2025,10.21037/jtd-2025-341,https://pubmed.ncbi.nlm.nih.gov/40400969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,41491534,CORT silencing impairs migration and invasion: validation of a glycosylation-based risk model (CORT/LPAR5/CEBPA/MYH10/MAGEA11) in osteosarcoma.,2026,10.1186/s40001-025-03744-4,https://pubmed.ncbi.nlm.nih.gov/41491534/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,39082035,Expression pattern analysis of the MAGE family genes in breast cancer patients and hypomethylation activation in the MCF-7 cells.,2024,10.1016/j.heliyon.2024.e34506,https://pubmed.ncbi.nlm.nih.gov/39082035/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,36341564,Molecular Characteristics of Bladder Tumor: Increased Gene Expression of MAGE-A6 and MAGE-A11 with Decreased MicroRNA-34a and MicroRNA-125b.,2022,10.18502/ijaai.v21i5.11043,https://pubmed.ncbi.nlm.nih.gov/36341564/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,41153666,Gender- and Grade-Dependent Activation of Androgen Receptor Signaling in Adult-Type Diffuse Gliomas: Epigenetic Insights from a Retrospective Cohort Study.,2025,10.3390/biomedicines13102379,https://pubmed.ncbi.nlm.nih.gov/41153666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,35022469,Co-expression of cancer-testis antigens of MAGE-A6 and MAGE-A11 is associated with tumor aggressiveness in patients with bladder cancer.,2022,10.1038/s41598-021-04510-2,https://pubmed.ncbi.nlm.nih.gov/35022469/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,35132168,Publisher Correction: Co-expression of cancer-testis antigens of MAGE-A6 and MAGE-A11 is associated with tumor aggressiveness in patients with bladder cancer.,2022,10.1038/s41598-022-06282-9,https://pubmed.ncbi.nlm.nih.gov/35132168/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,36292195,MAGEA11 as a STAD Prognostic Biomarker Associated with Immune Infiltration.,2022,10.3390/diagnostics12102506,https://pubmed.ncbi.nlm.nih.gov/36292195/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,37057240,Identification of Cancer/Testis Antigens Related to Gastric Cancer Prognosis Based on Co-Expression Network and Integrated Transcriptome Analyses.,2023,10.4103/abr.abr_400_21,https://pubmed.ncbi.nlm.nih.gov/37057240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,29574604,Evolution of Melanoma Antigen-A11 (MAGEA11) During Primate Phylogeny.,2018,10.1007/s00239-018-9838-8,https://pubmed.ncbi.nlm.nih.gov/29574604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,36804154,The Disruption of Mage-11 Gene via CRISPR/Cas9 Method Induced Apoptosis in the in vitro Model of Prostate Cancer.,2023,,https://pubmed.ncbi.nlm.nih.gov/36804154/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,32161495,MAGE-A11 Expression Predicts Patient Prognosis in Head and Neck Squamous Cell Carcinoma.,2020,10.2147/cmar.s237867,https://pubmed.ncbi.nlm.nih.gov/32161495/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,35710477,Blockade of TIM-3 and PD-1 enhances the antitumor effects of MAGE-A11 antigen-specific cytotoxic T lymphocytes.,2022,10.1016/j.bulcan.2022.04.005,https://pubmed.ncbi.nlm.nih.gov/35710477/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,32529260,Epigenetic modulation combined with PD-1/PD-L1 blockade enhances immunotherapy based on MAGE-A11 antigen-specific CD8+T cells against esophageal carcinoma.,2020,10.1093/carcin/bgaa057,https://pubmed.ncbi.nlm.nih.gov/32529260/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,28486273,Zebularine Treatment Induces MAGE-A11 Expression and Improves CTL Cytotoxicity Using a Novel Identified HLA-A2-restricted MAGE-A11 Peptide.,2017,10.1097/cji.0000000000000170,https://pubmed.ncbi.nlm.nih.gov/28486273/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,33169789,Cytotoxic T-lymphocyte elicited therapeutic vaccine candidate targeting cancer against MAGE-A11 carcinogenic protein.,2020,10.1042/bsr20202349,https://pubmed.ncbi.nlm.nih.gov/33169789/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,33004795,Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases.,2020,10.1038/s41467-020-18708-x,https://pubmed.ncbi.nlm.nih.gov/33004795/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,36807122,Metastasis-Related Signature for Clinically Predicting Prognosis and Tumor Immune Microenvironment of Osteosarcoma Patients.,2023,10.1007/s12033-023-00681-7,https://pubmed.ncbi.nlm.nih.gov/36807122/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,37124627,"Unveiling DNA damage repair-based molecular subtypes, tumor microenvironment and pharmacogenomic landscape in gastric cancer.",2023,10.3389/fgene.2023.1118889,https://pubmed.ncbi.nlm.nih.gov/37124627/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,29423052,MAGE-A11 is activated through TFCP2/ZEB1 binding sites de-methylation as well as histone modification and facilitates ESCC tumor growth.,2018,10.18632/oncotarget.22973,https://pubmed.ncbi.nlm.nih.gov/29423052/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA11,ENSG00000185247,CTA,15684378,Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction.,2005,10.1128/mcb.25.4.1238-1257.2005,https://pubmed.ncbi.nlm.nih.gov/15684378/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
MAGEA4,ENSG00000147381,CTA,42517272,"The evolution of cellular therapies in sarcoma: Breakthroughs, challenges, and future directions.",2026,10.1080/21645515.2026.2708435,https://pubmed.ncbi.nlm.nih.gov/42517272/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,42675026,Artificial intelligence-assisted design of MAGE-A4 ×CD16 T-cell receptor-like natural killer cell engagers.,2026,10.1080/19420862.2026.2717991,https://pubmed.ncbi.nlm.nih.gov/42675026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,42476725,"Phase 1/2 study of IMC-C103C, a T cell receptor bispecific (MAGE-A4×CD3) ImmTAC targeting MAGE-A4-expressing malignancies.",2026,10.1136/jitc-2025-014638,https://pubmed.ncbi.nlm.nih.gov/42476725/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,41469662,Overexpression of cancer testis antigens in gastric cancer and their correlations with the patients' clinicopathological characteristics.,2025,10.1186/s12920-025-02295-1,https://pubmed.ncbi.nlm.nih.gov/41469662/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,42673884,MAGEA4 promotes gastric cancer progression by inducing chromosomal instability through the STAU1/c-Myc axis.,2026,10.1016/j.cancergen.2026.08.006,https://pubmed.ncbi.nlm.nih.gov/42673884/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,41760259,"Immunohistochemical Expression and Clinicopathological Assessment of PD-1, PD-L1, NY-ESO-1, and MAGE-A4 Expression in Desmoid Tumor.",2026,10.21873/anticanres.18037,https://pubmed.ncbi.nlm.nih.gov/41760259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,42084830,Oncogenic MAGEA4 directs neuroendocrine differentiation and survival in prostate cancer cells through the SIRT1/Acetyl-p53/BCL-2 axis.,2026,10.1007/s11033-026-11878-9,https://pubmed.ncbi.nlm.nih.gov/42084830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,41480010,Preclinical assessment of MAGE-A4-specific TCR-NK cells against solid tumors.,2026,10.1093/immadv/ltaf036,https://pubmed.ncbi.nlm.nih.gov/41480010/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,42219399,MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial.,2026,10.1038/s41591-026-04455-x,https://pubmed.ncbi.nlm.nih.gov/42219399/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,40395161,"Correction to ""Expression of Cancer-Testis Antigens MAGE-A1, MAGE-A4, NY-ESO-1 and PRAME in Bone and Soft Tissue Sarcomas: The Experience From a Single Center in China"".",2025,10.1002/cam4.70971,https://pubmed.ncbi.nlm.nih.gov/40395161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,42079663,Translational strategy to support the first-in-human study of a TCR-like T cell bispecific with an &lt;i&gt;in vitro&lt;/i&gt;-based safety approach.,2026,10.3389/fimmu.2026.1736584,https://pubmed.ncbi.nlm.nih.gov/42079663/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,39941782,Adoptive T Cell Therapy Targeting MAGE-A4.,2025,10.3390/cancers17030413,https://pubmed.ncbi.nlm.nih.gov/39941782/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,39970827,Melanoma-associated antigen A4: A cancer/testis antigen as a target for adoptive T-cell receptor T-cell therapy.,2025,10.1016/j.ctrv.2025.102891,https://pubmed.ncbi.nlm.nih.gov/39970827/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,41645880,Temporal dynamics of Sertoli and germ cell development in human foetal and prepubertal testis.,2026,10.1242/bio.062319,https://pubmed.ncbi.nlm.nih.gov/41645880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,42734903,Top advances of the year in autologous cellular therapy in melanoma and solid tumors.,2026,10.1002/cncr.70612,https://pubmed.ncbi.nlm.nih.gov/42734903/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,41345672,mRNA-based immunotherapy platform targeting endometrial cancer.,2025,10.1186/s12967-025-07497-w,https://pubmed.ncbi.nlm.nih.gov/41345672/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,39704015,Evaluation of MAGE-A4 expression in breast cancer and its impact on prognosis.,2025,10.1111/cas.16433,https://pubmed.ncbi.nlm.nih.gov/39704015/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,40152485,"Expression of Cancer-Testis Antigens MAGE-A1, MAGE-A4, NY-ESO-1 and PRAME in Bone and Soft Tissue Sarcomas: The Experience From a Single Center in China.",2025,10.1002/cam4.70750,https://pubmed.ncbi.nlm.nih.gov/40152485/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,40151801,Mapping MAGE-A4 expression in solid cancers for targeted therapies.,2025,10.3389/fonc.2025.1484182,https://pubmed.ncbi.nlm.nih.gov/40151801/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,39937892,MAGE-A4 induces non-small cell lung cancer and tumor-promoting plasma cell accumulation.,2025,10.1126/sciadv.ads4227,https://pubmed.ncbi.nlm.nih.gov/39937892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,42321382,Author Correction: MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial.,2026,10.1038/s41591-026-04519-y,https://pubmed.ncbi.nlm.nih.gov/42321382/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,40423661,"FDA Approval Summary: Afamitresgene Autoleucel for Adults with HLA-Restricted, MAGE-A4-Positive Unresectable or Metastatic Synovial Sarcoma after Prior Chemotherapy.",2025,10.1158/1078-0432.ccr-25-0595,https://pubmed.ncbi.nlm.nih.gov/40423661/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,42099873,Advances in cell therapy for solid tumours: European perspective and future directions.,2026,10.1016/j.lanepe.2026.101590,https://pubmed.ncbi.nlm.nih.gov/42099873/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,39905312,"Exploring the role and mechanisms of MAGEA4 in tumorigenesis, regulation, and immunotherapy.",2025,10.1186/s10020-025-01079-8,https://pubmed.ncbi.nlm.nih.gov/39905312/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,41526168,Cell therapy in sarcoma: current landscape and future directions.,2026,10.1136/jitc-2025-013396,https://pubmed.ncbi.nlm.nih.gov/41526168/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,42184246,The Landscape of Clinical Trials for TCR-T Cell Therapy.,2026,10.1097/coc.0000000000001335,https://pubmed.ncbi.nlm.nih.gov/42184246/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA4,ENSG00000147381,CTA,40282478,Review of Adoptive Cellular Therapies for the Treatment of Sarcoma.,2025,10.3390/cancers17081302,https://pubmed.ncbi.nlm.nih.gov/40282478/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,42836846,MAGEA6 Promoted Gastric Cancer Progression by Activating Mitophagy.,2026,10.1002/mc.70189,https://pubmed.ncbi.nlm.nih.gov/42836846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,42041682,A Pan-Cancer Transcriptomic Signature for Conserved Molecular Programs Underlying Premalignant-Malignant Progression Across Common Carcinomas.,2026,10.3390/dj14040228,https://pubmed.ncbi.nlm.nih.gov/42041682/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,41452900,Integrated analysis of single-cell and bulk RNA-seq reveals MAGEA3/6-associated immune subtypes and key immune genes in gastric cancer.,2025,10.1371/journal.pone.0338705,https://pubmed.ncbi.nlm.nih.gov/41452900/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,40631515,An SNP-dependent cancer-testis antigenic epitope serves as a promising immunotherapeutic target for cancer.,2025,10.1080/2162402x.2025.2528110,https://pubmed.ncbi.nlm.nih.gov/40631515/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,40145793,MAGEA6 Engages a YY1-Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer.,2025,10.1002/advs.202501119,https://pubmed.ncbi.nlm.nih.gov/40145793/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,41489697,Serum cancer testis antigen MAGEA3-IgG serves as a diagnostic biomarker in lung adenocarcinoma.,2026,10.1007/s12094-025-04173-9,https://pubmed.ncbi.nlm.nih.gov/41489697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,39409926,ANKRD1 Promotes Breast Cancer Metastasis by Activating NF-κB-MAGE-A6 Pathway.,2024,10.3390/cancers16193306,https://pubmed.ncbi.nlm.nih.gov/39409926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,38285780,Expression of MAGE A1 to MAGE A10 in the Forceps Biopsy and Bronchoalveolar Lavage Specimens from Patients with the Central Lung Tumor.,2024,10.31557/apjcp.2024.25.1.159,https://pubmed.ncbi.nlm.nih.gov/38285780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,39370446,Targeting oncogenic MAGEA6 sensitizes triple negative breast cancer to doxorubicin through its autophagy and ferroptosis by stabling AMPKα1.,2024,10.1038/s41420-024-02196-9,https://pubmed.ncbi.nlm.nih.gov/39370446/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,39082035,Expression pattern analysis of the MAGE family genes in breast cancer patients and hypomethylation activation in the MCF-7 cells.,2024,10.1016/j.heliyon.2024.e34506,https://pubmed.ncbi.nlm.nih.gov/39082035/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,36341564,Molecular Characteristics of Bladder Tumor: Increased Gene Expression of MAGE-A6 and MAGE-A11 with Decreased MicroRNA-34a and MicroRNA-125b.,2022,10.18502/ijaai.v21i5.11043,https://pubmed.ncbi.nlm.nih.gov/36341564/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,42169880,Prognostic genes in hepatocellular carcinoma and their function: an analysis integrating high-throughput-based spatial transcriptomics and single-cell RNA-sequencing.,2026,10.21037/jgo-2026-1-0014,https://pubmed.ncbi.nlm.nih.gov/42169880/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,38378601,Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia.,2024,10.1186/s40164-024-00489-4,https://pubmed.ncbi.nlm.nih.gov/38378601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,35022469,Co-expression of cancer-testis antigens of MAGE-A6 and MAGE-A11 is associated with tumor aggressiveness in patients with bladder cancer.,2022,10.1038/s41598-021-04510-2,https://pubmed.ncbi.nlm.nih.gov/35022469/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,41169265,Comprehensive Colorectal Cancer Stem Cell Transcriptomic Signatures That Can Predict Patient Prognostic Outcomes.,2026,10.1111/cas.70235,https://pubmed.ncbi.nlm.nih.gov/41169265/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,35132168,Publisher Correction: Co-expression of cancer-testis antigens of MAGE-A6 and MAGE-A11 is associated with tumor aggressiveness in patients with bladder cancer.,2022,10.1038/s41598-022-06282-9,https://pubmed.ncbi.nlm.nih.gov/35132168/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,38966281,The whole transcriptome analysis using FFPE and fresh tissue samples identifies the molecular fingerprint of osteosarcoma.,2024,10.3389/ebm.2024.10161,https://pubmed.ncbi.nlm.nih.gov/38966281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,39315163,A necroptosis-regulated model from single-cell analysis that predicts survival and identifies the Pivotal role of MAGEA6 in hepatocellular carcinoma.,2024,10.1016/j.heliyon.2024.e37711,https://pubmed.ncbi.nlm.nih.gov/39315163/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,36589698,A library of cancer testis specific T cell receptors for T cell receptor gene therapy.,2023,10.1016/j.omto.2022.11.007,https://pubmed.ncbi.nlm.nih.gov/36589698/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,35285568,Knockdown of MAGE-A6 enhanced the irradiation sensitivity of non-small cell lung cancer cells by activating the AMPK pathway.,2022,10.1002/tox.23519,https://pubmed.ncbi.nlm.nih.gov/35285568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,35987136,"Chemical complementarity between tumor resident, T-cell receptor CDR3s and MAGEA3/6 correlates with increased melanoma survival: Potential relevance to MAGE vaccine auto-reactivity.",2022,10.1016/j.molimm.2022.08.001,https://pubmed.ncbi.nlm.nih.gov/35987136/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,38694506,Predictive value of a stemness-based classifier for prognosis and immunotherapy response of hepatocellular carcinoma based on bioinformatics and machine-learning strategies.,2024,10.3389/fimmu.2024.1244392,https://pubmed.ncbi.nlm.nih.gov/38694506/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,35126707,MAGEA6 positively regulates MSMO1 and promotes the migration and invasion of oesophageal cancer cells.,2022,10.3892/etm.2022.11127,https://pubmed.ncbi.nlm.nih.gov/35126707/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,36750254,Suitability of tumor-associated antibodies as predictive biomarker for response to immune checkpoint inhibitors in patients with melanoma: a short report.,2023,10.1136/jitc-2022-006467,https://pubmed.ncbi.nlm.nih.gov/36750254/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,32809888,The roles of MAGEA6 variants in pancreatic cancer development and their potential impact on cancer immunotherapy.,2020,10.1080/15548627.2020.1802091,https://pubmed.ncbi.nlm.nih.gov/32809888/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,36250008,A novel cuproptosis-related prognostic signature and potential value in HCC immunotherapy.,2022,10.3389/fmolb.2022.1001788,https://pubmed.ncbi.nlm.nih.gov/36250008/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,32270762,Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression.,2020,10.7554/elife.48963,https://pubmed.ncbi.nlm.nih.gov/32270762/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA6,ENSG00000197172,CTA,25960935,Molecular mimicry of MAGE-A6 and Mycoplasma penetrans HF-2 epitopes in the induction of antitumor CD8+ T-cell responses.,2014,10.4161/21624011.2014.954501,https://pubmed.ncbi.nlm.nih.gov/25960935/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,42219399,MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial.,2026,10.1038/s41591-026-04455-x,https://pubmed.ncbi.nlm.nih.gov/42219399/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,41489697,Serum cancer testis antigen MAGEA3-IgG serves as a diagnostic biomarker in lung adenocarcinoma.,2026,10.1007/s12094-025-04173-9,https://pubmed.ncbi.nlm.nih.gov/41489697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,39863862,Identification of novel cytoskeleton protein involved in spermatogenic cells and sertoli cells of non-obstructive azoospermia based on microarray and bioinformatics analysis.,2025,10.1186/s12920-025-02087-7,https://pubmed.ncbi.nlm.nih.gov/39863862/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,39082035,Expression pattern analysis of the MAGE family genes in breast cancer patients and hypomethylation activation in the MCF-7 cells.,2024,10.1016/j.heliyon.2024.e34506,https://pubmed.ncbi.nlm.nih.gov/39082035/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,37505763,The MAGE A1-A10 Expression associated with Histopathological Findings of Malignant or Non-Malignant Cells in Peripheral Lung Tumors.,2023,10.31557/apjcp.2023.24.7.2329,https://pubmed.ncbi.nlm.nih.gov/37505763/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,38285780,Expression of MAGE A1 to MAGE A10 in the Forceps Biopsy and Bronchoalveolar Lavage Specimens from Patients with the Central Lung Tumor.,2024,10.31557/apjcp.2024.25.1.159,https://pubmed.ncbi.nlm.nih.gov/38285780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,38114231,Autologous engineered T cell receptor therapy in advanced cancer.,2023,10.1080/21645515.2023.2290356,https://pubmed.ncbi.nlm.nih.gov/38114231/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,37100770,Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM.,2023,10.1038/s41467-023-37532-7,https://pubmed.ncbi.nlm.nih.gov/37100770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,31143371,Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells.,2019,10.18632/oncotarget.26933,https://pubmed.ncbi.nlm.nih.gov/31143371/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,31516568,Prognostic roles of MAGE family members in breast cancer based on KM-Plotter Data.,2019,10.3892/ol.2019.10722,https://pubmed.ncbi.nlm.nih.gov/31516568/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,27226137,The Magea gene cluster regulates male germ cell apoptosis without affecting the fertility in mice.,2016,10.1038/srep26735,https://pubmed.ncbi.nlm.nih.gov/27226137/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,26622942,Immuno-stimultory/regulatory gene expression patterns in advanced ovarian cancer.,2015,10.18632/genesandcancer.78,https://pubmed.ncbi.nlm.nih.gov/26622942/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,25123082,Low-dose decitabine induces MAGE-A expression and inhibits invasion via suppression of NF-κB2 and MMP2 in Eca109 cells.,2014,10.1016/j.biopha.2014.07.013,https://pubmed.ncbi.nlm.nih.gov/25123082/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,21785609,Expression patterns of cancer-testis antigens in human embryonic stem cells and their cell derivatives indicate lineage tracks.,2011,10.4061/2011/795239,https://pubmed.ncbi.nlm.nih.gov/21785609/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,15213716,MAGE-A8 overexpression in transitional cell carcinoma of the bladder: identification of two tumour-associated antigen peptides.,2004,10.1038/sj.bjc.6601968,https://pubmed.ncbi.nlm.nih.gov/15213716/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,23377668,Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy.,2013,10.1097/cji.0b013e3182829903,https://pubmed.ncbi.nlm.nih.gov/23377668/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,25872923,MAGE-A expression clusters and antineoplastic treatment in head and neck cancer.,2015,10.3892/ijmm.2015.2174,https://pubmed.ncbi.nlm.nih.gov/25872923/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,19934341,Lack of evidence for green tea polyphenols as DNA methylation inhibitors in murine prostate.,2009,10.1158/1940-6207.capr-09-0010,https://pubmed.ncbi.nlm.nih.gov/19934341/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,23430338,Correlation of MAGE-A tumor antigens and the efficacy of various chemotherapeutic agents in head and neck carcinoma cells.,2014,10.1007/s00784-013-0936-0,https://pubmed.ncbi.nlm.nih.gov/23430338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,25774687,The identification of specific methylation patterns across different cancers.,2015,10.1371/journal.pone.0120361,https://pubmed.ncbi.nlm.nih.gov/25774687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,42321382,Author Correction: MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial.,2026,10.1038/s41591-026-04519-y,https://pubmed.ncbi.nlm.nih.gov/42321382/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA8,ENSG00000156009,CTA,17290406,MAGE-A9 mRNA and protein expression in bladder cancer.,2007,10.1002/ijc.22282,https://pubmed.ncbi.nlm.nih.gov/17290406/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9B,ENSG00000267978,CTA,38398111,Transcriptomic Profiling for Prognostic Biomarkers in Early-Stage Squamous Cell Lung Cancer (SqCLC).,2024,10.3390/cancers16040720,https://pubmed.ncbi.nlm.nih.gov/38398111/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9B,ENSG00000267978,CTA,36430456,"Chromosomally Unstable Gastric Cancers Overexpressing Claudin-6 Disclose Cross-Talk between HNF1A and HNF4A, and Upregulated Cholesterol Metabolism.",2022,10.3390/ijms232213977,https://pubmed.ncbi.nlm.nih.gov/36430456/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9B,ENSG00000267978,CTA,20548033,Concomitant tumor and autoantigen vaccination supports renal cell carcinoma rejection.,2010,10.4049/jimmunol.0902683,https://pubmed.ncbi.nlm.nih.gov/20548033/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,40218304,"Preliminary Exploration of &lt;i&gt;MAGE-B1&lt;/i&gt;, &lt;i&gt;-B4&lt;/i&gt;, &lt;i&gt;-B5&lt;/i&gt;, and &lt;i&gt;-B10&lt;/i&gt; mRNA Expression in Canine Mammary Tumors in Dogs.",2025,10.3390/ani15070910,https://pubmed.ncbi.nlm.nih.gov/40218304/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,39082035,Expression pattern analysis of the MAGE family genes in breast cancer patients and hypomethylation activation in the MCF-7 cells.,2024,10.1016/j.heliyon.2024.e34506,https://pubmed.ncbi.nlm.nih.gov/39082035/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,39318439,Partial Lipodystrophy Affecting the Extremities in a Young Woman With Autoimmune Polyglandular Syndrome 1.,2024,10.1210/jcemcr/luae166,https://pubmed.ncbi.nlm.nih.gov/39318439/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,38450186,Humoral immunoprofiling identifies novel biomarkers and an immune suppressive autoantibody phenotype at the site of disease in pancreatic ductal adenocarcinoma.,2024,10.3389/fonc.2024.1330419,https://pubmed.ncbi.nlm.nih.gov/38450186/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,35937396,Expression Profile of MAGE-B1 Gene and Its Hypomethylation Activation in Colon Cancer.,2022,10.1155/2022/6066567,https://pubmed.ncbi.nlm.nih.gov/35937396/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,38230069,Retracted: Expression Profile of MAGE-B1 Gene and Its Hypomethylation Activation in Colon Cancer.,2024,10.1155/2024/9815982,https://pubmed.ncbi.nlm.nih.gov/38230069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,36139375,IgG+ Extracellular Vesicles Measure Therapeutic Response in Advanced Pancreatic Cancer.,2022,10.3390/cells11182800,https://pubmed.ncbi.nlm.nih.gov/36139375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,30006881,Specific Features of Transcription Activity of Cancer-Testis Antigens in Patients with Metastatic and Non-Metastatic Breast Cancer.,2018,10.1007/s10517-018-4175-x,https://pubmed.ncbi.nlm.nih.gov/30006881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,36105405,Sphingolipid metabolism is associated with osteosarcoma metastasis and prognosis: Evidence from interaction analysis.,2022,10.3389/fendo.2022.983606,https://pubmed.ncbi.nlm.nih.gov/36105405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,31143371,Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells.,2019,10.18632/oncotarget.26933,https://pubmed.ncbi.nlm.nih.gov/31143371/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,27656210,X-Linked Adrenal Hypoplasia Congenita in a Boy due to a Novel Deletion of the Entire NR0B1 (DAX1) and MAGEB1-4 Genes.,2016,10.1155/2016/5178953,https://pubmed.ncbi.nlm.nih.gov/27656210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,34307667,Trophinin Is an Important Biomarker and Prognostic Factor in Osteosarcoma: Data Mining from Oncomine and the Cancer Genome Atlas Databases.,2021,10.1155/2021/6885897,https://pubmed.ncbi.nlm.nih.gov/34307667/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,26885621,Novel potential serological prostate cancer biomarkers using CT100+ cancer antigen microarray platform in a multi-cultural South African cohort.,2016,10.18632/oncotarget.7359,https://pubmed.ncbi.nlm.nih.gov/26885621/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,30429015,Detection of autoantibodies against cancer-testis antigens in non-small cell lung cancer.,2018,10.1016/j.lungcan.2018.09.012,https://pubmed.ncbi.nlm.nih.gov/30429015/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,12211215,Potential mouse tumor model for pre-clinical testing of mage-specific breast cancer vaccines.,2002,10.1023/a:1016367104015,https://pubmed.ncbi.nlm.nih.gov/12211215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,9441743,Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins.,1997,10.1006/geno.1997.5052,https://pubmed.ncbi.nlm.nih.gov/9441743/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,12018852,"Hypertonicity induction of melanoma antigen, a tumor-associated antigen.",2002,10.1016/s1016-8478(23)15035-7,https://pubmed.ncbi.nlm.nih.gov/12018852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,11223546,Expression of MAGE-B genes in esophageal squamous cell carcinoma.,2001,10.1111/j.1349-7006.2001.tb01079.x,https://pubmed.ncbi.nlm.nih.gov/11223546/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,15723723,Expression of cancer/testis (CT) antigens in Chinese hepatocellular carcinoma and its correlation with clinical parameters.,2005,10.1016/j.canlet.2004.07.028,https://pubmed.ncbi.nlm.nih.gov/15723723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,15201976,Prognostic significance of cancer-testis gene expression in resected non-small cell lung cancer patients.,2004,10.3892/or.12.1.145,https://pubmed.ncbi.nlm.nih.gov/15201976/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,15868428,Prevention of metastases with a Mage-b DNA vaccine in a mouse breast tumor model: potential for breast cancer therapy.,2005,10.1007/s10549-004-6454-7,https://pubmed.ncbi.nlm.nih.gov/15868428/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,15059354,[Expression of MAGE-B genes in hepatocellular carcinoma].,2004,,https://pubmed.ncbi.nlm.nih.gov/15059354/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB1,ENSG00000214107,CTA,17208331,Differential expression profile of MAGE family in non-small-cell lung cancer.,2007,10.1016/j.lungcan.2006.12.004,https://pubmed.ncbi.nlm.nih.gov/17208331/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB18,ENSG00000176774,CTA,38309723,Comprehensive multiplexed autoantibody profiling of patients with advanced urothelial cancer.,2024,10.1136/jitc-2023-008215,https://pubmed.ncbi.nlm.nih.gov/38309723/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB18,ENSG00000176774,CTA,33718161,"A Survival-Related Competitive Endogenous RNA Network of Prognostic lncRNAs, miRNAs, and mRNAs in Wilms Tumor.",2021,10.3389/fonc.2021.608433,https://pubmed.ncbi.nlm.nih.gov/33718161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB18,ENSG00000176774,CTA,34307667,Trophinin Is an Important Biomarker and Prognostic Factor in Osteosarcoma: Data Mining from Oncomine and the Cancer Genome Atlas Databases.,2021,10.1155/2021/6885897,https://pubmed.ncbi.nlm.nih.gov/34307667/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB18,ENSG00000176774,CTA,31516568,Prognostic roles of MAGE family members in breast cancer based on KM-Plotter Data.,2019,10.3892/ol.2019.10722,https://pubmed.ncbi.nlm.nih.gov/31516568/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB18,ENSG00000176774,CTA,22332604,The mouse Mageb18 gene encodes a ubiquitously expressed type I MAGE protein and regulates cell proliferation and apoptosis in melanoma B16-F0 cells.,2012,10.1042/bj20112054,https://pubmed.ncbi.nlm.nih.gov/22332604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB3,ENSG00000198798,CTA,35937396,Expression Profile of MAGE-B1 Gene and Its Hypomethylation Activation in Colon Cancer.,2022,10.1155/2022/6066567,https://pubmed.ncbi.nlm.nih.gov/35937396/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB3,ENSG00000198798,CTA,34307667,Trophinin Is an Important Biomarker and Prognostic Factor in Osteosarcoma: Data Mining from Oncomine and the Cancer Genome Atlas Databases.,2021,10.1155/2021/6885897,https://pubmed.ncbi.nlm.nih.gov/34307667/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB3,ENSG00000198798,CTA,29927686,Loci-specific differences in blood DNA methylation in HBV-negative populations at risk for hepatocellular carcinoma development.,2018,10.1080/15592294.2018.1481706,https://pubmed.ncbi.nlm.nih.gov/29927686/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB3,ENSG00000198798,CTA,12211215,Potential mouse tumor model for pre-clinical testing of mage-specific breast cancer vaccines.,2002,10.1023/a:1016367104015,https://pubmed.ncbi.nlm.nih.gov/12211215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB3,ENSG00000198798,CTA,20648585,Differential gene expression profile of MAGE family in taiwanese patients with colorectal cancer.,2010,10.1002/jso.21580,https://pubmed.ncbi.nlm.nih.gov/20648585/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB3,ENSG00000198798,CTA,9441743,Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins.,1997,10.1006/geno.1997.5052,https://pubmed.ncbi.nlm.nih.gov/9441743/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB3,ENSG00000198798,CTA,16455969,Hyperthermia enhances CTL cross-priming.,2006,10.4049/jimmunol.176.4.2134,https://pubmed.ncbi.nlm.nih.gov/16455969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,40417674,Prognostic impact of dynamic changes of type I melanoma antigen gene proteins CT7 (&lt;i&gt;MAGE-C1/CT7&lt;/i&gt;) transcripts in multiple myeloma.,2025,10.3389/fmed.2025.1566265,https://pubmed.ncbi.nlm.nih.gov/40417674/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,39598359,Increased MAGE-C Family Gene Expression Levels as a Biomarker of Colon Cancer Through the Demethylation Mechanism.,2024,10.3390/ph17111447,https://pubmed.ncbi.nlm.nih.gov/39598359/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,39125568,An Immunohistochemical Study of MAGE Proteins in Hepatocellular Carcinoma.,2024,10.3390/diagnostics14151692,https://pubmed.ncbi.nlm.nih.gov/39125568/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,37835834,Characterization of Cancer/Testis Antigens as Prognostic Markers of Ovarian Cancer.,2023,10.3390/diagnostics13193092,https://pubmed.ncbi.nlm.nih.gov/37835834/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,41153666,Gender- and Grade-Dependent Activation of Androgen Receptor Signaling in Adult-Type Diffuse Gliomas: Epigenetic Insights from a Retrospective Cohort Study.,2025,10.3390/biomedicines13102379,https://pubmed.ncbi.nlm.nih.gov/41153666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,40626660,Evaluation of a Novel &lt;i&gt;MAGEC1&lt;/i&gt; Variant and Susceptibility to Ovarian Cancer in the North Indian Population.,2025,10.1089/gtmb.2025.0029,https://pubmed.ncbi.nlm.nih.gov/40626660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,39267058,Whole exome sequencing analysis of 167 men with primary infertility.,2024,10.1186/s12920-024-02005-3,https://pubmed.ncbi.nlm.nih.gov/39267058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,40486681,Distinct germ-line genetic mutation patterns correlate with reproductive outcomes in ICSI patients: a pilot study.,2025,10.3389/fgene.2025.1610943,https://pubmed.ncbi.nlm.nih.gov/40486681/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,35070414,High expression of MAGE-C1 gene in colorectal cancer is associated with its poor prognosis.,2021,10.21037/jgo-21-739,https://pubmed.ncbi.nlm.nih.gov/35070414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,33902161,Expression of cancer testis antigens in thymic epithelial tumors.,2021,10.1111/pin.13103,https://pubmed.ncbi.nlm.nih.gov/33902161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,34462402,The expression of multiple cancer/testis antigens can potentially be used to detect circulating disease and clonal evolution in the peripheral blood of multiple myeloma patients.,2021,10.5045/br.2021.2020335,https://pubmed.ncbi.nlm.nih.gov/34462402/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,31222935,MAGE genes: Prognostic indicators in AL amyloidosis patients.,2019,10.1111/jcmm.14475,https://pubmed.ncbi.nlm.nih.gov/31222935/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,39580273,Melanoma antigen genes (MAGE); novel functional targets in multiple myeloma.,2025,10.1053/j.seminhematol.2024.10.007,https://pubmed.ncbi.nlm.nih.gov/39580273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,29163685,"Expression of cancer/testis antigens MAGE-A, MAGE-C1, GAGE and CTAG1B in benign and malignant thyroid diseases.",2017,10.3892/ol.2017.7072,https://pubmed.ncbi.nlm.nih.gov/29163685/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,32327728,Oncolytic measles virus therapy enhances tumor antigen-specific T-cell responses in patients with multiple myeloma.,2020,10.1038/s41375-020-0828-7,https://pubmed.ncbi.nlm.nih.gov/32327728/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,37392243,IGL CDR3 Hydropathy and Antigen Chemical Complementarity Associated with Greater Disease-Free Survival in Lung Adenocarcinoma: Implications for Gender Disparities.,2024,10.1007/s10528-023-10437-2,https://pubmed.ncbi.nlm.nih.gov/37392243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,23180015,MAGE-C1/CT7 and MAGE-C2/CT10 are frequently expressed in multiple myeloma and can be explored in combined immunotherapy for this malignancy.,2013,10.1007/s00262-012-1376-4,https://pubmed.ncbi.nlm.nih.gov/23180015/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,32799221,[Regulation of Gene Expression of Cancer/Testis Antigens in Colorectal Cancer Patients].,2020,10.31857/s0026898420040096,https://pubmed.ncbi.nlm.nih.gov/32799221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,31428638,"Erratum to ""Intratumoral Heterogeneity of MAGE-C1/CT7 and MAGE-C2/CT10 Expression in Mucosal Melanoma"".",2019,10.1155/2019/5256364,https://pubmed.ncbi.nlm.nih.gov/31428638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,27581737,Cancer testis antigen MAGE C1 can be used to monitor levels of circulating malignant stem cells in the peripheral blood of multiple myeloma patients.,2016,10.1007/s00432-016-2231-3,https://pubmed.ncbi.nlm.nih.gov/27581737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,30736848,"Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer.",2019,10.1186/s40425-019-0520-5,https://pubmed.ncbi.nlm.nih.gov/30736848/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,31428094,In vitro Generation of Cytotoxic T Cells With Potential for Adoptive Tumor Immunotherapy of Multiple Myeloma.,2019,10.3389/fimmu.2019.01792,https://pubmed.ncbi.nlm.nih.gov/31428094/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,30421674,Design of Artificial Immunogens Containing Melanoma-associated T-cell Epitopes.,2018,10.2174/1566523218666181113112829,https://pubmed.ncbi.nlm.nih.gov/30421674/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,24896625,Is there any relationship between gene expression of tumor antigens and CD4+ T cells in multiple myeloma?,2014,10.2217/imt.14.24,https://pubmed.ncbi.nlm.nih.gov/24896625/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,25288198,Phase Ib study evaluating a self-adjuvanted mRNA cancer vaccine (RNActive®) combined with local radiation as consolidation and maintenance treatment for patients with stage IV non-small cell lung cancer.,2014,10.1186/1471-2407-14-748,https://pubmed.ncbi.nlm.nih.gov/25288198/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,28512265,Chaetocin enhances dendritic cell function via the induction of heat shock protein and cancer testis antigens in myeloma cells.,2017,10.18632/oncotarget.17517,https://pubmed.ncbi.nlm.nih.gov/28512265/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,23882157,NY-ESO-1-specific immunological pressure and escape in a patient with metastatic melanoma.,2013,,https://pubmed.ncbi.nlm.nih.gov/23882157/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,26321295,The expression of MAGE-C1 and MAGE-C2 in breast cancer and their clinical significance.,2016,10.1016/j.amjsurg.2015.05.028,https://pubmed.ncbi.nlm.nih.gov/26321295/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC1,ENSG00000155495,CTA,24340093,Centrosomal localisation of the cancer/testis (CT) antigens NY-ESO-1 and MAGE-C1 is regulated by proteasome activity in tumour cells.,2013,10.1371/journal.pone.0083212,https://pubmed.ncbi.nlm.nih.gov/24340093/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,42343456,MAGEC2 promotes tumorigenesis in multiple myeloma through USP16-mediated deubiquitination and stabilization of c-Myc.,2026,10.1186/s40164-026-00782-4,https://pubmed.ncbi.nlm.nih.gov/42343456/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,40395227,Vaccination with synthetic long peptide and CpG 2395 in AddaVax induces potent anti-tumor effects.,2025,10.3389/ebm.2025.10509,https://pubmed.ncbi.nlm.nih.gov/40395227/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,42041682,A Pan-Cancer Transcriptomic Signature for Conserved Molecular Programs Underlying Premalignant-Malignant Progression Across Common Carcinomas.,2026,10.3390/dj14040228,https://pubmed.ncbi.nlm.nih.gov/42041682/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,39598359,Increased MAGE-C Family Gene Expression Levels as a Biomarker of Colon Cancer Through the Demethylation Mechanism.,2024,10.3390/ph17111447,https://pubmed.ncbi.nlm.nih.gov/39598359/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,39125568,An Immunohistochemical Study of MAGE Proteins in Hepatocellular Carcinoma.,2024,10.3390/diagnostics14151692,https://pubmed.ncbi.nlm.nih.gov/39125568/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,40195438,Engineered PD-L1 co-expression in PD-1 knockout and MAGE-C2-targeting TCR-T cells augments the cytotoxic efficacy toward target cancer cells.,2025,10.1038/s41598-025-92209-z,https://pubmed.ncbi.nlm.nih.gov/40195438/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,41153666,Gender- and Grade-Dependent Activation of Androgen Receptor Signaling in Adult-Type Diffuse Gliomas: Epigenetic Insights from a Retrospective Cohort Study.,2025,10.3390/biomedicines13102379,https://pubmed.ncbi.nlm.nih.gov/41153666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,35355564,Identification of MAGEC2/CT10 as a High Calcium-Inducible Gene in Triple-Negative Breast Cancer.,2022,10.3389/fendo.2022.816598,https://pubmed.ncbi.nlm.nih.gov/35355564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,37341056,Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer.,2023,10.1002/1878-0261.13474,https://pubmed.ncbi.nlm.nih.gov/37341056/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,29257297,Cancer‑testis antigen HCA587/MAGEC2 interacts with the general transcription coactivator TAF9 in cancer cells.,2018,10.3892/mmr.2017.8260,https://pubmed.ncbi.nlm.nih.gov/29257297/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,32723258,HCA587 Protein Vaccine Induces Specific Antitumor Immunity Mediated by CD4+ T-cells Expressing Granzyme B in a Mouse Model of Melanoma.,2021,10.2174/1871520620666200728131951,https://pubmed.ncbi.nlm.nih.gov/32723258/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,27076846,MicroRNA-874 Functions as a Tumor Suppressor by Targeting Cancer/Testis Antigen HCA587/MAGE-C2.,2016,10.7150/jca.13674,https://pubmed.ncbi.nlm.nih.gov/27076846/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,37498497,Retraction Note: MAGE-C2/CT10 promotes growth and metastasis through upregulating c-Myc expression in prostate cancer.,2023,10.1007/s11010-023-04820-1,https://pubmed.ncbi.nlm.nih.gov/37498497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,35970555,Clinical Correlation of Function and TCR vβ Diversity of MAGE-C2-Specific CD8+ T Cell Response in Esophageal Cancer.,2022,10.4049/jimmunol.2101182,https://pubmed.ncbi.nlm.nih.gov/35970555/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,35927984,The Dual Roles of MAGE-C2 in p53 Ubiquitination and Cell Proliferation Through E3 Ligases MDM2 and TRIM28.,2022,10.3389/fcell.2022.922675,https://pubmed.ncbi.nlm.nih.gov/35927984/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,30309319,Post-transcriptional regulation of cancer/testis antigen MAGEC2 expression by TRIM28 in tumor cells.,2018,10.1186/s12885-018-4844-1,https://pubmed.ncbi.nlm.nih.gov/30309319/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,39315163,A necroptosis-regulated model from single-cell analysis that predicts survival and identifies the Pivotal role of MAGEA6 in hepatocellular carcinoma.,2024,10.1016/j.heliyon.2024.e37711,https://pubmed.ncbi.nlm.nih.gov/39315163/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,33818016,Increased Melanoma-Associated Antigen C2 Expression Affords Resistance to Apoptotic Deathin Suspension-Cultured Tumor Cells.,2021,10.4048/jbc.2021.24.e6,https://pubmed.ncbi.nlm.nih.gov/33818016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,31222935,MAGE genes: Prognostic indicators in AL amyloidosis patients.,2019,10.1111/jcmm.14475,https://pubmed.ncbi.nlm.nih.gov/31222935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,32935296,MAGE-C2/CT10 promotes growth and metastasis through upregulating c-Myc expression in prostate cancer.,2021,10.1007/s11010-020-03814-7,https://pubmed.ncbi.nlm.nih.gov/32935296/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,39245893,Immunoinformatic approach to design an efficient multi-epitope peptide vaccine against melanoma.,2025,10.1002/bab.2654,https://pubmed.ncbi.nlm.nih.gov/39245893/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,38380261,Application of the iPLUS non-coding sequence in improving biopharmaceuticals production.,2024,10.3389/fbioe.2024.1355957,https://pubmed.ncbi.nlm.nih.gov/38380261/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,34430349,Randomized phase II trial of a first-in-human cancer cell lysate vaccine in patients with thoracic malignancies.,2021,10.21037/tlcr-21-1,https://pubmed.ncbi.nlm.nih.gov/34430349/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,30736848,"Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer.",2019,10.1186/s40425-019-0520-5,https://pubmed.ncbi.nlm.nih.gov/30736848/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,36750254,Suitability of tumor-associated antibodies as predictive biomarker for response to immune checkpoint inhibitors in patients with melanoma: a short report.,2023,10.1136/jitc-2022-006467,https://pubmed.ncbi.nlm.nih.gov/36750254/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,32114500,TriMix and tumor antigen mRNA electroporated dendritic cell vaccination plus ipilimumab: link between T-cell activation and clinical responses in advanced melanoma.,2020,10.1136/jitc-2019-000329,https://pubmed.ncbi.nlm.nih.gov/32114500/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,31727154,Blood-derived dendritic cell vaccinations induce immune responses that correlate with clinical outcome in patients with chemo-naive castration-resistant prostate cancer.,2019,10.1186/s40425-019-0787-6,https://pubmed.ncbi.nlm.nih.gov/31727154/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,36827041,Novel diagnostic biomarkers of T cell-mediated tumor killing characteristics for early-stage triple negative breast cancer: A SEER analysis and molecular portraits.,2023,10.1097/md.0000000000033059,https://pubmed.ncbi.nlm.nih.gov/36827041/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEC2,ENSG00000046774,CTA,12920247,HCA587 antigen expression in normal tissues and cancers: correlation with tumor differentiation in hepatocellular carcinoma.,2003,10.1097/01.lab.0000080605.73839.96,https://pubmed.ncbi.nlm.nih.gov/12920247/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
MAGEC2,ENSG00000046774,CTA,12097419,Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.,2002,10.4049/jimmunol.169.2.1102,https://pubmed.ncbi.nlm.nih.gov/12097419/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,42854377,Meiotic recombination proteins in cancer.,2026,10.1016/j.dnarep.2026.103963,https://pubmed.ncbi.nlm.nih.gov/42854377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,40296718,New feature of hMEIOB and hSPATA22 binding to ssDNA from a single-molecule perspective.,2025,10.3724/abbs.2025057,https://pubmed.ncbi.nlm.nih.gov/40296718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,39932629,Genetic insights into non-obstructive azoospermia: Implications for diagnosis and TESE outcomes.,2025,10.1007/s10815-025-03409-5,https://pubmed.ncbi.nlm.nih.gov/39932629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,40867525,Comparative Analysis of Testicular Transcriptional and Translational Landscapes in Yak and Cattle-Yak: Implications for Hybrid Male Sterility.,2025,10.3390/biom15081080,https://pubmed.ncbi.nlm.nih.gov/40867525/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,42466588,Genome-Wide Resequencing Reveals Genetic Diversity and Selection Signatures in Two Indigenous Goat Populations From Xizang.,2026,10.1002/age.70162,https://pubmed.ncbi.nlm.nih.gov/42466588/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,39753050,Molecular mechanisms of libido influencing semen quality in geese through the hypothalamic-pituitary-testicular-external genitalia axis.,2025,10.1016/j.psj.2024.104756,https://pubmed.ncbi.nlm.nih.gov/39753050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,39162221,Meiotic chromatin-associated HSF5 is indispensable for pachynema progression and male fertility.,2024,10.1093/nar/gkae701,https://pubmed.ncbi.nlm.nih.gov/39162221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,42133574,ssDNA dynamics during mammalian meiotic recombination†.,2026,10.1093/biolre/ioag102,https://pubmed.ncbi.nlm.nih.gov/42133574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,39061157,Transcriptome-Wide Association Study Reveals New Molecular Interactions Associated with Melanoma Pathogenesis.,2024,10.3390/cancers16142517,https://pubmed.ncbi.nlm.nih.gov/39061157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,40754083,Ribosome profiling sequencing reveals translational dynamics during yak testicular development.,2025,10.1016/j.ijbiomac.2025.146519,https://pubmed.ncbi.nlm.nih.gov/40754083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,41392145,A genome-wide association study reveals additive and recessive alleles affecting male fertility in pigs.,2025,10.1186/s40104-025-01312-8,https://pubmed.ncbi.nlm.nih.gov/41392145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,35991565,Novel MEIOB variants cause primary ovarian insufficiency and non-obstructive azoospermia.,2022,10.3389/fgene.2022.936264,https://pubmed.ncbi.nlm.nih.gov/35991565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,33628586,"The cancer-testis gene, MEIOB, sensitizes triple-negative breast cancer to PARP1 inhibitors by inducing homologous recombination deficiency.",2021,10.20892/j.issn.2095-3941.2020.0071,https://pubmed.ncbi.nlm.nih.gov/33628586/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,42106700,"Association between air pollution exposure and increased chronic kidney disease risk: the modifying effects of genetic susceptibility, transcriptomic, and proteomic signatures.",2026,10.1186/s12916-026-04909-6,https://pubmed.ncbi.nlm.nih.gov/42106700/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,33166385,The ssDNA-binding protein MEIOB acts as a dosage-sensitive regulator of meiotic recombination.,2020,10.1093/nar/gkaa1016,https://pubmed.ncbi.nlm.nih.gov/33166385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,39545410,Defects in meiosis I contribute to the genesis of androgenetic hydatidiform moles.,2024,10.1172/jci170669,https://pubmed.ncbi.nlm.nih.gov/39545410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,36230452,F1 Male Sterility in Cattle-Yak Examined through Changes in Testis Tissue and Transcriptome Profiles.,2022,10.3390/ani12192711,https://pubmed.ncbi.nlm.nih.gov/36230452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,36331299,Nuclear localization of human MEIOB requires its NLS in the OB domain and interaction with SPATA22.,2022,10.3724/abbs.2022156,https://pubmed.ncbi.nlm.nih.gov/36331299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,32463099,A cell-based high-content screen identifies isocotoin as a small molecule inhibitor of the meiosis-specific MEIOB-SPATA22 complex†.,2020,10.1093/biolre/ioaa062,https://pubmed.ncbi.nlm.nih.gov/32463099/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,38672141,Exome Sequencing to Identify Novel Variants Associated with Secondary Amenorrhea and Premature Ovarian Insufficiency (POI) in Saudi Women.,2024,10.3390/biomedicines12040785,https://pubmed.ncbi.nlm.nih.gov/38672141/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,34392356,Whole-exome sequencing of consanguineous families with infertile men and women identifies homologous mutations in SPATA22 and MEIOB.,2021,10.1093/humrep/deab185,https://pubmed.ncbi.nlm.nih.gov/34392356/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,38664359,Evaluation of an Updated Gene Panel as a Diagnostic Tool for Both Male and Female Infertility.,2024,10.1007/s43032-024-01553-4,https://pubmed.ncbi.nlm.nih.gov/38664359/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,24440806,"Identification of a meiosis-specific protein, MEIOB, as a novel cancer/testis antigen and its augmented expression in demethylated cancer cells.",2014,10.1016/j.imlet.2014.01.004,https://pubmed.ncbi.nlm.nih.gov/24440806/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,30838384,A new MEIOB mutation is a recurrent cause for azoospermia and testicular meiotic arrest.,2019,10.1093/humrep/dez016,https://pubmed.ncbi.nlm.nih.gov/30838384/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,31000419,A truncating MEIOB mutation responsible for familial primary ovarian insufficiency abolishes its interaction with its partner SPATA22 and their recruitment to DNA double-strand breaks.,2019,10.1016/j.ebiom.2019.03.075,https://pubmed.ncbi.nlm.nih.gov/31000419/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,28453612,Meiosis-specific proteins MEIOB and SPATA22 cooperatively associate with the single-stranded DNA-binding replication protein A complex and DNA double-strand breaks.,2017,10.1093/biolre/iox040,https://pubmed.ncbi.nlm.nih.gov/28453612/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,26813108,Systematic identification of genes with a cancer-testis expression pattern in 19 cancer types.,2016,10.1038/ncomms10499,https://pubmed.ncbi.nlm.nih.gov/26813108/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,28206990,A familial study of azoospermic men identifies three novel causative mutations in three new human azoospermia genes.,2017,10.1038/gim.2016.225,https://pubmed.ncbi.nlm.nih.gov/28206990/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOB,ENSG00000162039,CTA,24068956,MEIOB targets single-strand DNA and is necessary for meiotic recombination.,2013,10.1371/journal.pgen.1003784,https://pubmed.ncbi.nlm.nih.gov/24068956/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOC,ENSG00000180336,CTA,42479652,Molecular genetics of meiotic initiation in mammals.,2026,10.1093/biolre/ioag155,https://pubmed.ncbi.nlm.nih.gov/42479652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOC,ENSG00000180336,CTA,42291182,A mechanism of target mRNA selection and activity regulation in meiosis-related RBM46-MEIOC-YTHDC2 complex.,2026,10.1016/j.isci.2026.116234,https://pubmed.ncbi.nlm.nih.gov/42291182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOC,ENSG00000180336,CTA,40705004,Meioc-Piwil1 complexes regulate rRNA transcription for differentiation of spermatogonial stem cells.,2025,10.7554/elife.104295,https://pubmed.ncbi.nlm.nih.gov/40705004/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOC,ENSG00000180336,CTA,41287933,MEIOC prevents continued mitotic cycling and promotes meiotic entry during mouse oogenesis.,2026,10.1242/dev.205037,https://pubmed.ncbi.nlm.nih.gov/41287933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOC,ENSG00000180336,CTA,42217413,RBM46 promotes meiotic initiation during oogenesis.,2026,10.1016/j.bbrc.2026.154058,https://pubmed.ncbi.nlm.nih.gov/42217413/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOC,ENSG00000180336,CTA,38526201,Gut-Derived Exosomes Mediate the Microbiota Dysbiosis-Induced Spermatogenesis Impairment by Targeting Meioc in Mice.,2024,10.1002/advs.202310110,https://pubmed.ncbi.nlm.nih.gov/38526201/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOC,ENSG00000180336,CTA,38884383,Destabilization of mRNAs enhances competence to initiate meiosis in mouse spermatogenic cells.,2024,10.1242/dev.202740,https://pubmed.ncbi.nlm.nih.gov/38884383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOC,ENSG00000180336,CTA,40815662,Initiation of meiosis from human iPSCs under defined conditions through identification of regulatory factors.,2025,10.1126/sciadv.adu0384,https://pubmed.ncbi.nlm.nih.gov/40815662/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOC,ENSG00000180336,CTA,39378093,YTHDC2 serves a distinct late role in spermatocytes during germ cell differentiation.,2024,10.1073/pnas.2309548121,https://pubmed.ncbi.nlm.nih.gov/39378093/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOC,ENSG00000180336,CTA,39030605,N6-methyladenosine writer METTL16-mediated alternative splicing and translation control are essential for murine spermatogenesis.,2024,10.1186/s13059-024-03332-5,https://pubmed.ncbi.nlm.nih.gov/39030605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOC,ENSG00000180336,CTA,36001654,RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis.,2022,10.1126/sciadv.abq2945,https://pubmed.ncbi.nlm.nih.gov/36001654/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOC,ENSG00000180336,CTA,42249589,Novel variants in YTHDC2 cause non-obstructive azoospermia by disrupting the mitotic-to-meiotic transition in humans and mice.,2026,10.1093/humrep/deag086,https://pubmed.ncbi.nlm.nih.gov/42249589/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOC,ENSG00000180336,CTA,37846121,[Therapeutic effect of Heirong Kidney-Tonifying Granule on busulfan-induced dyszoospermia in model mice].,2022,,https://pubmed.ncbi.nlm.nih.gov/37846121/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOC,ENSG00000180336,CTA,28380054,Meioc maintains an extended meiotic prophase I in mice.,2017,10.1371/journal.pgen.1006704,https://pubmed.ncbi.nlm.nih.gov/28380054/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOC,ENSG00000180336,CTA,29360036,ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2.,2018,10.7554/elife.30919,https://pubmed.ncbi.nlm.nih.gov/29360036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOC,ENSG00000180336,CTA,26742488,Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts.,2016,10.1038/ncomms10324,https://pubmed.ncbi.nlm.nih.gov/26742488/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOC,ENSG00000180336,CTA,26619122,Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma.,2016,10.1172/jci82066,https://pubmed.ncbi.nlm.nih.gov/26619122/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4D,ENSG00000205301,CTA,41244580,"Evolutionary analyses of the animal glycosyltransferase family 54 reveals two β1,4-N-acetylglucosaminyltransferase families.",2025,10.1016/j.isci.2025.113788,https://pubmed.ncbi.nlm.nih.gov/41244580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4D,ENSG00000205301,CTA,32034218,The Golgi Glycoprotein MGAT4D is an Intrinsic Protector of Testicular Germ Cells From Mild Heat Stress.,2020,10.1038/s41598-020-58923-6,https://pubmed.ncbi.nlm.nih.gov/32034218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4D,ENSG00000205301,CTA,32763972,"Point mutations that inactivate MGAT4D-L, an inhibitor of MGAT1 and complex N-glycan synthesis.",2020,10.1074/jbc.ra120.014784,https://pubmed.ncbi.nlm.nih.gov/32763972/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4D,ENSG00000205301,CTA,26371870,GnT1IP-L specifically inhibits MGAT1 in the Golgi via its luminal domain.,2015,10.7554/elife.08916,https://pubmed.ncbi.nlm.nih.gov/26371870/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4D,ENSG00000205301,CTA,16773575,ELMOD2 is a candidate gene for familial idiopathic pulmonary fibrosis.,2006,10.1086/504639,https://pubmed.ncbi.nlm.nih.gov/16773575/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,42729551,MORC1 coordinates TRIM28 interaction and nuclear condensate formation for transposon silencing.,2026,10.1016/j.isci.2026.117394,https://pubmed.ncbi.nlm.nih.gov/42729551/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,42531888,Ameliorative effects of myricetin nanoparticles on carbon tetrachloride-induced spermatogenic dysfunction in mice.,2026,10.1016/j.repbio.2026.101268,https://pubmed.ncbi.nlm.nih.gov/42531888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,41414675,Stage-dependent dual mechanisms of MORC2 in retrotransposon silencing and sex chromosome inactivation in germ cells.,2025,10.1093/nar/gkaf1362,https://pubmed.ncbi.nlm.nih.gov/41414675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,40085777,The kinase CPK5 phosphorylates MICRORCHIDIA1 to promote broad-spectrum disease resistance.,2025,10.1093/plcell/koaf051,https://pubmed.ncbi.nlm.nih.gov/40085777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,39812044,Bioinformatics Analysis Reveals Microrchidia Family Genes as the Prognostic and Therapeutic Markers for Colorectal Cancer.,2025,10.2174/0118715303367767241231113110,https://pubmed.ncbi.nlm.nih.gov/39812044/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,40823841,AP2X-1 is a negative regulator of &lt;i&gt;Toxoplasma gondii&lt;/i&gt; sexual commitment.,2025,10.1128/mbio.00052-25,https://pubmed.ncbi.nlm.nih.gov/40823841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,40540580,Regulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism in &lt;i&gt;C. elegans&lt;/i&gt;.,2025,10.1126/sciadv.ado4170,https://pubmed.ncbi.nlm.nih.gov/40540580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,39766294,Effects of Early Stress Exposure on Anxiety-like Behavior and &lt;i&gt;MORC1&lt;/i&gt; Expression in Rats.,2024,10.3390/biom14121587,https://pubmed.ncbi.nlm.nih.gov/39766294/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,42210236,Targeting MORC2 activates transposable element-mediated viral mimicry and potentiates immune checkpoint blockade in triple-negative breast cancer.,2026,10.1186/s12943-026-02679-6,https://pubmed.ncbi.nlm.nih.gov/42210236/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,41272393,MORC proteins: critical epigenetic players in plants.,2026,10.1111/nph.70767,https://pubmed.ncbi.nlm.nih.gov/41272393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,41607057,MORC-ALKBH1 antagonism shapes three-dimensional gene regulation in rice.,2026,10.1111/jipb.70163,https://pubmed.ncbi.nlm.nih.gov/41607057/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,42449406,Genetic architecture and cross-platform validation of apolipoprotein A-IV concentrations.,2026,10.1186/s13059-026-04196-7,https://pubmed.ncbi.nlm.nih.gov/42449406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,34331083,Morc1 as a potential new target gene in mood regulation: when and where to find in the brain.,2021,10.1007/s00221-021-06171-z,https://pubmed.ncbi.nlm.nih.gov/34331083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,39397299,Arabidopsis MORC1 and MED9 Interact to Regulate Defense Gene Expression and Plant Fitness.,2024,10.5423/ppj.oa.07.2024.0107,https://pubmed.ncbi.nlm.nih.gov/39397299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,40817150,Microrchidia ATPases and DNA 6mA demethylase ALKBH1 act antagonistically on PRC2 to control chromatin structure and stress tolerance.,2025,10.1038/s41477-025-02048-z,https://pubmed.ncbi.nlm.nih.gov/40817150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,38502704,Morc1 reestablishes H3K9me3 heterochromatin on piRNA-targeted transposons in gonocytes.,2024,10.1073/pnas.2317095121,https://pubmed.ncbi.nlm.nih.gov/38502704/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,42873826,Human cytomegalovirus exploits host chromatin remodeler MORC2 to promote the DNA damage response on viral genomes.,2026,10.1371/journal.ppat.1014693,https://pubmed.ncbi.nlm.nih.gov/42873826/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,41686642,Protocol to enhance pre-sexual and sexual differentiation of Toxoplasma gondii using retinal cells and intestinal organoid-derived monolayers.,2026,10.1016/j.xpro.2026.104367,https://pubmed.ncbi.nlm.nih.gov/41686642/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,40171615,The complex immune puzzle: A deeper dive into the MORC1-mediated broad-spectrum defense signaling pathway.,2025,10.1093/plcell/koaf075,https://pubmed.ncbi.nlm.nih.gov/40171615/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,36732020,Plant mobile domain proteins ensure Microrchidia 1 expression to fulfill transposon silencing.,2023,10.26508/lsa.202201539,https://pubmed.ncbi.nlm.nih.gov/36732020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,41290487,Frequent genetic alterations in myositis autoantigen genes in cancer-associated dermatomyositis.,2026,10.1016/j.ard.2025.10.018,https://pubmed.ncbi.nlm.nih.gov/41290487/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,39129223,Whole exome sequencing analyses identified novel genes for Alzheimer's disease and related dementia.,2024,10.1002/alz.14181,https://pubmed.ncbi.nlm.nih.gov/39129223/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,40389644,Uncovering biomarkers for chronic toxoplasmosis detection highlights alternative pathways shaping parasite dormancy.,2025,10.1038/s44321-025-00252-0,https://pubmed.ncbi.nlm.nih.gov/40389644/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,40092938,Expression significance of biomarker MORC4 in colorectal cancer patients and its relationship with pathological features and prognosis.,2025,10.4251/wjgo.v17.i3.102434,https://pubmed.ncbi.nlm.nih.gov/40092938/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,36034976,Differentially expressed liver exosome-related genes as candidate prognostic biomarkers for hepatocellular carcinoma.,2022,10.21037/atm-21-4400,https://pubmed.ncbi.nlm.nih.gov/36034976/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,39329063,Genome-wide analysis reveals the MORC3-mediated repression of PD-L1 expression in head and neck cancer.,2024,10.3389/fcell.2024.1410130,https://pubmed.ncbi.nlm.nih.gov/39329063/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,35592101,Immune Repertoire and Advancements in Nanotherapeutics for the Impediment of Severe Steroid Resistant Asthma (SSR).,2022,10.2147/ijn.s364693,https://pubmed.ncbi.nlm.nih.gov/35592101/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,31442422,The Gene-Silencing Protein MORC-1 Topologically Entraps DNA and Forms Multimeric Assemblies to Cause DNA Compaction.,2019,10.1016/j.molcel.2019.07.032,https://pubmed.ncbi.nlm.nih.gov/31442422/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,33384453,Maternal separation in rats induces neurobiological and behavioral changes on the maternal side.,2020,10.1038/s41598-020-80087-6,https://pubmed.ncbi.nlm.nih.gov/33384453/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,33302923,Self-expandable metallic stenting as a bridge to elective surgery versus emergency surgery for acute malignant right-sided colorectal obstruction.,2020,10.1186/s12893-020-00993-4,https://pubmed.ncbi.nlm.nih.gov/33302923/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,40265418,Cell-Type-Specific Heat-Induced Changes in the Proteomes of Pollen Mother Cells and Microspores Provide New Insights into Tomato Pollen Production Under Elevated Temperature.,2025,10.3390/proteomes13020013,https://pubmed.ncbi.nlm.nih.gov/40265418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,34695197,Morc2a p.S87L mutant mice develop peripheral and central neuropathies associated with neuronal DNA damage and apoptosis.,2021,10.1242/dmm.049123,https://pubmed.ncbi.nlm.nih.gov/34695197/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,32401166,Stabilization of MORC2 by estrogen and antiestrogens through GPER1- PRKACA-CMA pathway contributes to estrogen-induced proliferation and endocrine resistance of breast cancer cells.,2020,10.1080/15548627.2019.1659609,https://pubmed.ncbi.nlm.nih.gov/32401166/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORC1,ENSG00000114487,CTA,26896032,Comparative Study of Autoantibody Responses between Lung Adenocarcinoma and Benign Pulmonary Nodules.,2016,10.1016/j.jtho.2015.11.011,https://pubmed.ncbi.nlm.nih.gov/26896032/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,42625859,"Dysregulation of piRNA biogenesis-associated proteins in cancer: mechanisms, evidence, and translational constraints.",2026,10.3389/fmolb.2026.1906635,https://pubmed.ncbi.nlm.nih.gov/42625859/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,42417195,Cap 2'-O-methyltransferase CMTR2 regulates male meiosis independent of its methyltransferase activity.,2026,10.1093/nar/gkag699,https://pubmed.ncbi.nlm.nih.gov/42417195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,42711130,[Study of a patient with azoospermia due to variant of MOV10L1 gene].,2026,10.3760/cma.j.cn511374-20250813-00485,https://pubmed.ncbi.nlm.nih.gov/42711130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,42183021,The pachytene-specific lncRNA &lt;i&gt;1700008K24Rik&lt;/i&gt; is essential for mouse spermatogenesis and functions as a conserved piRNA precursor.,2026,10.1016/j.ncrna.2026.04.001,https://pubmed.ncbi.nlm.nih.gov/42183021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,42118831,Spatiotemporal control of PIWI compartmentalization by mitochondrial scaffolds defines pachytene piRNA pathway organization.,2026,10.1073/pnas.2533968123,https://pubmed.ncbi.nlm.nih.gov/42118831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,41681403,"Whole-Transcriptome Analysis of Gene Expression in Canine Splenic Lymphoid Hyperplasia, Complex Hyperplasia, Histiocytic Sarcoma, and Stromal Sarcoma.",2026,10.3390/ani16030422,https://pubmed.ncbi.nlm.nih.gov/41681403/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,41059337,Cracking the code: how piRNA pathway shapes spermatogenesis and combats male infertility.,2025,10.3389/fcell.2025.1657744,https://pubmed.ncbi.nlm.nih.gov/41059337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,42335787,Divergent early host transcriptional responses to H5N8 highly pathogenic avian influenza virus in chickens and ducks.,2026,10.1016/j.psj.2026.107242,https://pubmed.ncbi.nlm.nih.gov/42335787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,35886872,"Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence.",2022,10.3390/ijms23147523,https://pubmed.ncbi.nlm.nih.gov/35886872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,33635934,"yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis.",2021,10.1371/journal.pgen.1009265,https://pubmed.ncbi.nlm.nih.gov/33635934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,38396502,Effects of Heat Stress and Lipopolysaccharides on Gene Expression in Chicken Immune Cells.,2024,10.3390/ani14040532,https://pubmed.ncbi.nlm.nih.gov/38396502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,34489573,Formation of spermatogonia and fertile oocytes in golden hamsters requires piRNAs.,2021,10.1038/s41556-021-00746-2,https://pubmed.ncbi.nlm.nih.gov/34489573/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,36262887,Machine learning models identify ferroptosis-related genes as potential diagnostic biomarkers for Alzheimer's disease.,2022,10.3389/fnagi.2022.994130,https://pubmed.ncbi.nlm.nih.gov/36262887/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,31088452,Biological and RNA regulatory function of MOV10 in mammalian germ cells.,2019,10.1186/s12915-019-0659-z,https://pubmed.ncbi.nlm.nih.gov/31088452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,31037925,Comparison of Germ Cell Gene Expressions in Spontaneous Monolayer versus Embryoid Body Differentiation of Mouse Embryonic Stem Cells toward Germ Cells.,2019,10.22074/ijfs.2019.5557,https://pubmed.ncbi.nlm.nih.gov/31037925/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,35413094,Whole-exome sequencing in patients with maturation arrest: a potential additional diagnostic tool for prevention of recurrent negative testicular sperm extraction outcomes.,2022,10.1093/humrep/deac057,https://pubmed.ncbi.nlm.nih.gov/35413094/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,31252377,MOV10L1 Binds RNA G-Quadruplex in a Structure-Specific Manner and Resolves It More Efficiently Than MOV10.,2019,10.1016/j.isci.2019.06.016,https://pubmed.ncbi.nlm.nih.gov/31252377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,30288485,Evaluation of specific germ cell genes expression in mouse embryonic stem cell-derived germ cell like cells treated with bone morphogenetic protein 4 in vitro.,2018,10.29252/ijrm.16.8.507,https://pubmed.ncbi.nlm.nih.gov/30288485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,31132071,Enhanced Crosslinking Immunoprecipitation (eCLIP) Method for Efficient Identification of Protein-bound RNA in Mouse Testis.,2019,10.3791/59681,https://pubmed.ncbi.nlm.nih.gov/31132071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,32015435,Ribosomes guide pachytene piRNA formation on long intergenic piRNA precursors.,2020,10.1038/s41556-019-0457-4,https://pubmed.ncbi.nlm.nih.gov/32015435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,30290141,"Genomic Analyses from Non-invasive Prenatal Testing Reveal Genetic Associations, Patterns of Viral Infections, and Chinese Population History.",2018,10.1016/j.cell.2018.08.016,https://pubmed.ncbi.nlm.nih.gov/30290141/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,28548470,Whole-Exome Sequencing of ETV6/RUNX1 in Four Childhood Acute Lymphoblastic Leukaemia Cases,2017,10.22034/apjcp.2017.18.4.1169,https://pubmed.ncbi.nlm.nih.gov/28548470/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOV10L1,ENSG00000073146,CTA,11279525,An abundance of X-linked genes expressed in spermatogonia.,2001,10.1038/86927,https://pubmed.ncbi.nlm.nih.gov/11279525/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MROH2B,ENSG00000171495,CTA,41484547,"Integrative analysis of GWAS, Bayesian fine-mapping, Mendelian randomization and colocalization reveals genetic determinants underlying milk-related traits in dairy cattle.",2026,10.1186/s12711-025-01028-3,https://pubmed.ncbi.nlm.nih.gov/41484547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A6E,ENSG00000166926,CTA,39655660,Identification of Alzheimer's disease susceptibility genes by integrating eight human brain single-cell transcriptomes with genome-wide association studies.,2025,10.1111/jnc.16276,https://pubmed.ncbi.nlm.nih.gov/39655660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A6E,ENSG00000166926,CTA,33959712,Defining functional variants associated with Alzheimer's disease in the induced immune response.,2021,10.1093/braincomms/fcab083,https://pubmed.ncbi.nlm.nih.gov/33959712/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A6E,ENSG00000166926,CTA,36653487,Transcriptomic survey of key reproductive and metabolic tissues in mouse models of polycystic ovary syndrome.,2023,10.1038/s42003-022-04362-0,https://pubmed.ncbi.nlm.nih.gov/36653487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A6E,ENSG00000166926,CTA,23226438,Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains.,2012,10.1371/journal.pone.0050976,https://pubmed.ncbi.nlm.nih.gov/23226438/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A6E,ENSG00000166926,CTA,24829845,Late-Onset Alzheimer's Disease Genes and the Potentially Implicated Pathways.,2014,10.1007/s40142-014-0034-x,https://pubmed.ncbi.nlm.nih.gov/24829845/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A6E,ENSG00000166926,CTA,27005436,Gene-based aggregate SNP associations between candidate AD genes and cognitive decline.,2016,10.1007/s11357-016-9885-2,https://pubmed.ncbi.nlm.nih.gov/27005436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A6E,ENSG00000166926,CTA,24278680,The genetics of Alzheimer's disease.,2012,10.6064/2012/246210,https://pubmed.ncbi.nlm.nih.gov/24278680/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A6E,ENSG00000166926,CTA,23360175,Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci.,2013,10.1111/ahg.12000,https://pubmed.ncbi.nlm.nih.gov/23360175/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A6E,ENSG00000166926,CTA,22832961,Genome-wide association study of Alzheimer's disease.,2012,10.1038/tp.2012.45,https://pubmed.ncbi.nlm.nih.gov/22832961/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A6E,ENSG00000166926,CTA,25778476,A novel Alzheimer disease locus located near the gene encoding tau protein.,2016,10.1038/mp.2015.23,https://pubmed.ncbi.nlm.nih.gov/25778476/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A6E,ENSG00000166926,CTA,28199971,Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population.,2017,10.18632/oncotarget.15269,https://pubmed.ncbi.nlm.nih.gov/28199971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A6E,ENSG00000166926,CTA,21460841,"Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.",2011,10.1038/ng.801,https://pubmed.ncbi.nlm.nih.gov/21460841/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A6E,ENSG00000166926,CTA,22984654,Beta-amyloid toxicity modifier genes and the risk of Alzheimer's disease.,2012,,https://pubmed.ncbi.nlm.nih.gov/22984654/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A6E,ENSG00000166926,CTA,22384383,Genome-wide survey of large rare copy number variants in Alzheimer's disease among Caribbean hispanics.,2012,10.1534/g3.111.000869,https://pubmed.ncbi.nlm.nih.gov/22384383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAA11,ENSG00000156269,CTA,38234914,"Replication of previous autism-GWAS hits suggests the association between NAA1, SORCS3, and GSDME and autism in the Han Chinese population.",2024,10.1016/j.heliyon.2023.e23677,https://pubmed.ncbi.nlm.nih.gov/38234914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAA11,ENSG00000156269,CTA,39779553,Identification of a ceRNA Network Regulating Malignant Transformation of Isocitrate Dehydrogenase Mutant Astrocytoma: An Integrated Bioinformatics Study.,2025,10.2174/0115734099293010240810181446,https://pubmed.ncbi.nlm.nih.gov/39779553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAA11,ENSG00000156269,CTA,22048246,Expression of human NAA11 (ARD1B) gene is tissue-specific and is regulated by DNA methylation.,2011,10.4161/epi.6.11.18125,https://pubmed.ncbi.nlm.nih.gov/22048246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAA11,ENSG00000156269,CTA,34817046,RNA-binding protein with serine-rich domain 1 regulates microsatellite instability of uterine corpus endometrial adenocarcinoma.,2021,10.6061/clinics/2021/e3318,https://pubmed.ncbi.nlm.nih.gov/34817046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAA11,ENSG00000156269,CTA,36255299,Draft Genome Sequences of Four Strains of Plant Growth-Promoting Bacteria Associated with Maize Rhizosphere.,2022,10.1128/mra.00730-22,https://pubmed.ncbi.nlm.nih.gov/36255299/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAA11,ENSG00000156269,CTA,19246321,"Cloning, characterization, and expression analysis of the novel acetyltransferase retrogene Ard1b in the mouse.",2009,10.1095/biolreprod.108.073221,https://pubmed.ncbi.nlm.nih.gov/19246321/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAA11,ENSG00000156269,CTA,32942614,N-Terminal Acetyltransferases Are Cancer-Essential Genes Prevalently Upregulated in Tumours.,2020,10.3390/cancers12092631,https://pubmed.ncbi.nlm.nih.gov/32942614/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAA11,ENSG00000156269,CTA,32345704,Reference Genome Assembly for Australian Ascochyta rabiei Isolate ArME14.,2020,10.1534/g3.120.401265,https://pubmed.ncbi.nlm.nih.gov/32345704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAA11,ENSG00000156269,CTA,32677742,Gene fusions characterize a subset of uterine cellular leiomyomas.,2020,10.1002/gcc.22888,https://pubmed.ncbi.nlm.nih.gov/32677742/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAA11,ENSG00000156269,CTA,28317896,Use of RNA-seq data to identify and validate RT-qPCR reference genes for studying the tomato-Pseudomonas pathosystem.,2017,10.1038/srep44905,https://pubmed.ncbi.nlm.nih.gov/28317896/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAA11,ENSG00000156269,CTA,20419844,LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma.,2010,10.3748/wjg.v16.i16.2046,https://pubmed.ncbi.nlm.nih.gov/20419844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAA11,ENSG00000156269,CTA,28554338,The development of an intraruminal nylon bag technique using non-fistulated animals to assess the rumen degradability of dietary plant materials.,2018,10.1017/s1751731117001203,https://pubmed.ncbi.nlm.nih.gov/28554338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAA11,ENSG00000156269,CTA,9128724,"The aminonucleoside antibiotic A201A is inactivated by a phosphotransferase activity from Streptomyces capreolus NRRL 3817, the producing organism. Isolation and molecular characterization of the relevant encoding gene and its DNA flanking regions.",1997,10.1111/j.1432-1033.1997.00054.x,https://pubmed.ncbi.nlm.nih.gov/9128724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAA11,ENSG00000156269,CTA,16638120,"Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase.",2006,10.1186/1471-2091-7-13,https://pubmed.ncbi.nlm.nih.gov/16638120/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42543487,AID-Mediated Protein Knockdown Reveals the Requirement of NANOS2 in Prenatal Gonocytes for Establishing Functional Spermatogonial Stem Cells.,2026,10.1111/dgd.70064,https://pubmed.ncbi.nlm.nih.gov/42543487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42794788,Regulation of Inducible Nitric Oxide Synthase (NOS2) Expression in Healthy and Inflamed Bowel: A Narrative Review.,2026,10.3390/ijms27188359,https://pubmed.ncbi.nlm.nih.gov/42794788/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42524563,Spermatogonial stem cell markers and distribution in different regions of the testis of adult Nile tilapia (&lt;i&gt;Oreochromis niloticus&lt;/i&gt;).,2026,10.1590/1984-3143-ar2025-0162,https://pubmed.ncbi.nlm.nih.gov/42524563/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42777352,Integorated multi-omics reveals the NOS2-metabolite-microbiota regulatory axis underlying feed efficiency in laying hens.,2026,10.1016/j.psj.2026.107822,https://pubmed.ncbi.nlm.nih.gov/42777352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,40607105,Morula complementation restores male germline in &lt;i&gt;NANOS2&lt;/i&gt; null sheep.,2025,10.1093/pnasnexus/pgaf200,https://pubmed.ncbi.nlm.nih.gov/40607105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42862325,UBE2C-TRIM21-driven NOS2 degradation stabilizes Tregs and suppresses pyroptotic signaling in thyrocytes in Hashimoto's thyroiditis.,2026,10.1007/s00011-026-02375-7,https://pubmed.ncbi.nlm.nih.gov/42862325/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,40577378,Genome-wide landscape of miRNA-mRNA-lncRNA-circRNA ceRNA network in Nanos2 deficient mice.,2025,10.1371/journal.pone.0325260,https://pubmed.ncbi.nlm.nih.gov/40577378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42769810,"Innate Immune Profile in Diabetes Mellitus Rat Treated with Acalypha Indica Extract: Focus on TLR-2, TLR-4, &lt;i&gt;Nos2, Arg1&lt;/i&gt;, and Liver Inflammation.",2026,10.4103/ijpvm.ijpvm_334_24,https://pubmed.ncbi.nlm.nih.gov/42769810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,41815335,Microglial histone deacetylase-3 conditional deletion attenuates neurological deficits after intracerebral hemorrhage.,2026,10.3389/fncel.2026.1734472,https://pubmed.ncbi.nlm.nih.gov/41815335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42192880,TOP2 and NOS2 Orchestrate the Generation of DNA Breaks to Promote Colitis Cancer Initiation.,2026,10.3390/cancers18101519,https://pubmed.ncbi.nlm.nih.gov/42192880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42710678,Nitric oxide dependent metabolic and genetic dysregulation in metastatic triple-negative breast cancer.,2026,10.1016/j.jbc.2026.113526,https://pubmed.ncbi.nlm.nih.gov/42710678/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42097035,"NOS2 and COX2 impact the spatial landscape of CD8&lt;sup&gt;+&lt;/sup&gt; T cells in ER-breast cancer, providing novel mechanistic insight that drives tumor progression and poor survival.",2026,10.1016/j.redox.2026.104189,https://pubmed.ncbi.nlm.nih.gov/42097035/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42309721,Considerations for recipient male selection in a livestock Surrogate Sire breeding strategy.,2026,10.1262/jrd.2026-017,https://pubmed.ncbi.nlm.nih.gov/42309721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42248132,Nitric oxide-driven Warburg reprogramming at the NOS2-COX2 axis: An integrative engine of cancer hallmarks.,2026,10.1016/j.redox.2026.104245,https://pubmed.ncbi.nlm.nih.gov/42248132/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,41573553,NOS2/ARG1 axis and immune cell ratios as promising prognostic and predictive biomarkers for Cetuximab combined with chemotherapy in wt-KRAS human colorectal cancer.,2025,10.3389/fimmu.2025.1700487,https://pubmed.ncbi.nlm.nih.gov/41573553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,41532634,Nitric Oxide Synthase Expression in Endometrium During Physiological Cycle.,2025,,https://pubmed.ncbi.nlm.nih.gov/41532634/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42548794,Fangchinoline drives NOS2-dependent host immunity to restrict intracellular enteric pathogens.,2026,10.1016/j.isci.2026.116940,https://pubmed.ncbi.nlm.nih.gov/42548794/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,41796243,PGE2 regulates ferroptosis and osteogenesis of MC3T3-E1 cells via NOS2.,2026,10.1038/s41598-026-43001-0,https://pubmed.ncbi.nlm.nih.gov/41796243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42260542,Mechanistic evaluation of pachymic acid in breast cancer via network pharmacology and in vitro validation.,2026,10.1186/s12906-026-05420-4,https://pubmed.ncbi.nlm.nih.gov/42260542/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42072077,Endothelial Nitric Oxide Synthase-Dependent Mechanism of Hydroxyurea-Induced S-Phase Arrest in Erythroid Cells.,2026,10.3390/antiox15040435,https://pubmed.ncbi.nlm.nih.gov/42072077/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,41895288,Immunogenic tumor cell death and T-cell-derived IFN-γ elicit tumoricidal macrophages to potentiate OX40 immunotherapy.,2026,10.1016/j.xcrm.2026.102699,https://pubmed.ncbi.nlm.nih.gov/41895288/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42693091,PPARα activation overcomes fibroinflammatory liver microenvironment-associated anti-PD-1 resistance in hepatocellular carcinoma by mediating GSDME-dependent pyroptosis.,2026,10.1038/s41467-026-75770-7,https://pubmed.ncbi.nlm.nih.gov/42693091/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,41697735,STING-induced blood-brain barrier opening combined with radiotherapy potentiates antitumor response in a high-grade glioma model.,2026,10.1172/jci198843,https://pubmed.ncbi.nlm.nih.gov/41697735/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42337052,GABA signaling activation drives glioblastoma progression in female mice through myeloid-derived suppressor cells.,2026,10.1038/s43018-026-01192-5,https://pubmed.ncbi.nlm.nih.gov/42337052/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42816487,IFN-γ-driven iNOS induction in macrophages mediates CAR T cell resistance in B cell lymphoma.,2026,10.1038/s41467-026-76972-9,https://pubmed.ncbi.nlm.nih.gov/42816487/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42678381,Species-specific iNOS expression distinguishes epithelial and myeloid IFNγ responses in tuberculosis.,2026,10.1093/ajrcmb/aanag166,https://pubmed.ncbi.nlm.nih.gov/42678381/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42624032,Tumor-intrinsic PHGDH inhibition sensitizes colorectal cancer to PD-1 blockade via α-ketoglutarate-mediated macrophage reprogramming.,2026,10.1016/j.drup.2026.101464,https://pubmed.ncbi.nlm.nih.gov/42624032/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42873802,Exogenous nitric oxide as an anti-infective agent.,2026,10.1084/jem.20260043,https://pubmed.ncbi.nlm.nih.gov/42873802/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,40804697,MS4A4A-positive tumor-associated macrophages associate with poor prognosis and T-cell exhaustion in patients with urothelial carcinoma of the bladder.,2025,10.1002/path.6465,https://pubmed.ncbi.nlm.nih.gov/40804697/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42504956,Autophagy-nitric oxide reprogramming of immune metabolism: a potential avenue for asthma therapeutic advancement.,2026,10.1080/15548627.2026.2706403,https://pubmed.ncbi.nlm.nih.gov/42504956/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42876167,Transient manganese exposure reprograms bone marrow-derived macrophages toward a stable anti-inflammatory memory state.,2026,10.1093/jimmun/vkag267,https://pubmed.ncbi.nlm.nih.gov/42876167/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42119382,6:2 Cl-PFESA exacerbates osteoporosis by activating the Nos2-ROS-mtDNA-STING pathway in osteoclasts: An emerging osteoporotic threat.,2026,10.1016/j.ecoenv.2026.120241,https://pubmed.ncbi.nlm.nih.gov/42119382/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,42588111,Betulin Alleviates 5-Fluorouracil-Induced Intestinal Mucositis in Mice.,2026,10.3390/nu18152487,https://pubmed.ncbi.nlm.nih.gov/42588111/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,41922574,LDHA-driven lactate metabolism promotes MDSC activation and immunosuppressive microenvironment in prostate cancer.,2026,10.1038/s41388-026-03737-5,https://pubmed.ncbi.nlm.nih.gov/41922574/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,21421998,NANOS3 function in human germ cell development.,2011,10.1093/hmg/ddr114,https://pubmed.ncbi.nlm.nih.gov/21421998/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NANOS2,ENSG00000188425,CTA,19168545,The highly conserved NANOS2 protein: testis-specific expression and significance for the human male reproduction.,2009,10.1093/molehr/gap003,https://pubmed.ncbi.nlm.nih.gov/19168545/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,41714623,PAN2 maintains mRNA poly(A) tail homeostasis and regulates translation during spermiogenesis in mice.,2026,10.1038/s41467-026-69639-y,https://pubmed.ncbi.nlm.nih.gov/41714623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,42697823,Maternal PAN2 selectively maintains mRNA Poly(A) tail homeostasis to regulate RNA degradation during oocyte-to-early embryo transition in mice.,2026,10.1016/j.scib.2026.08.051,https://pubmed.ncbi.nlm.nih.gov/42697823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,42151529,Further delineation of the phenotype and genotype in a newly identified PAN2-related disorder.,2026,10.1038/s10038-026-01479-6,https://pubmed.ncbi.nlm.nih.gov/42151529/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,41556236,Pan2-Pan3 Complex-Mediated Deadenylation Enforces mRNA Quality Control for Infection of the Rice Blast Fungus.,2026,10.1002/advs.202518269,https://pubmed.ncbi.nlm.nih.gov/41556236/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,41120675,Integrating bulk and single-cell transcriptome to identify novel gene markers for germinal center B cells (GCB) subtype of diffuse large B-cell lymphoma.,2025,10.1007/s00277-025-06517-5,https://pubmed.ncbi.nlm.nih.gov/41120675/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,41851445,Degron models: a toolbox for rapid in vivo depletion of essential proteins regulating mRNA metabolism.,2026,10.1038/s42003-026-09828-z,https://pubmed.ncbi.nlm.nih.gov/41851445/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,40087771,NLRP4 unlocks an NK/macrophages-centered ecosystem to suppress non-small cell lung cancer.,2025,10.1186/s40364-025-00756-4,https://pubmed.ncbi.nlm.nih.gov/40087771/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,39187531,NLRP4 renders pancreatic cancer resistant to olaparib through promotion of the DNA damage response and ROS-induced autophagy.,2024,10.1038/s41419-024-06984-0,https://pubmed.ncbi.nlm.nih.gov/39187531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,40395525,NLRP4 drives olaparib resistance in pancreatic cancer.,2024,10.1080/27694127.2024.2422729,https://pubmed.ncbi.nlm.nih.gov/40395525/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,41233206,Genetic and embryonic transcriptome analyses reveal the molecular and developmental basis of Mayer-Rokitansky-Küster-Hauser syndrome.,2026,10.1136/jmg-2025-110805,https://pubmed.ncbi.nlm.nih.gov/41233206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,39725041,Alternative splicing landscape in mouse skeletal muscle and adipose tissue: Effects of intermittent fasting and exercise.,2025,10.1016/j.jnutbio.2024.109837,https://pubmed.ncbi.nlm.nih.gov/39725041/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,40276384,P62 inhibits IL-1β release during &lt;i&gt;Salmonella&lt;/i&gt; Typhimurium infection of macrophages.,2025,10.3389/fcimb.2025.1495567,https://pubmed.ncbi.nlm.nih.gov/40276384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,41518448,Deciphering the TLR4 and NLRP3 Inflammasome Crosstalk for Therapeutic Restoration of Intestinal and Systemic Immunity.,2026,10.1007/s10620-025-09655-y,https://pubmed.ncbi.nlm.nih.gov/41518448/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,35304602,Biallelic PAN2 variants in individuals with a syndromic neurodevelopmental disorder and multiple congenital anomalies.,2022,10.1038/s41431-022-01077-y,https://pubmed.ncbi.nlm.nih.gov/35304602/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,41835261,Regulation of stomatal development by receptor-like kinases and receptor-like proteins in &lt;i&gt;Arabidopsis&lt;/i&gt; and grasses.,2026,10.3389/fpls.2026.1770946,https://pubmed.ncbi.nlm.nih.gov/41835261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,40654364,ALKBH3-regulated m&lt;sup&gt;1&lt;/sup&gt;A of ALDOA potentiates glycolysis and doxorubicin resistance of triple negative breast cancer cells.,2025,10.1016/j.apsb.2025.04.018,https://pubmed.ncbi.nlm.nih.gov/40654364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,38730334,NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis.,2024,10.1186/s11658-024-00580-y,https://pubmed.ncbi.nlm.nih.gov/38730334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,39392373,Deubiquitylase USP52 Promotes Bladder Cancer Progression by Modulating Ferroptosis through Stabilizing SLC7A11/xCT.,2024,10.1002/advs.202403995,https://pubmed.ncbi.nlm.nih.gov/39392373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,35467709,The hyper-expression of NLRP4 characterizes the occurrence of macrophage activation syndrome assessing STING pathway in adult-onset Still's disease.,2022,10.1093/cei/uxac014,https://pubmed.ncbi.nlm.nih.gov/35467709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,38091268,Revealing the expression profile of genes that encode the Subcortical Maternal Complex in human reproductive failures.,2023,10.1590/1678-4685-gmb-2023-0141,https://pubmed.ncbi.nlm.nih.gov/38091268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,34927309,NLRP4 negatively regulates type I interferon response and influences the outcome in anti-programmed cell death protein (PD)-1/PD-ligand 1 therapy.,2022,10.1111/cas.15243,https://pubmed.ncbi.nlm.nih.gov/34927309/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,38582251,Wiskott Aldrich syndrome protein (WASp)-deficient Th1 cells promote R-loop-driven transcriptional insufficiency and transcription-coupled nucleotide excision repair factor (TC-NER)-driven genome-instability in the pathogenesis of T cell acute lymphoblastic leukemia.,2024,10.1016/j.clim.2024.110204,https://pubmed.ncbi.nlm.nih.gov/38582251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,30747829,Development and Biological Analysis of a Novel Orthotopic Peritoneal Dissemination Mouse Model Generated Using a Pancreatic Ductal Adenocarcinoma Cell Line.,2019,10.1097/mpa.0000000000001253,https://pubmed.ncbi.nlm.nih.gov/30747829/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,28888400,Characterization of inflammasome-related genes in urine sediments of patients receiving intravesical BCG therapy.,2017,10.1016/j.urolonc.2017.08.004,https://pubmed.ncbi.nlm.nih.gov/28888400/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,33692205,Oncolytic Foamy Virus - generation and properties of a nonpathogenic replicating retroviral vector system that targets chronically proliferating cancer cells.,2021,10.1128/jvi.00015-21,https://pubmed.ncbi.nlm.nih.gov/33692205/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,32511256,Synthetic PreImplantation Factor (sPIF) reduces inflammation and prevents preterm birth.,2020,10.1371/journal.pone.0232493,https://pubmed.ncbi.nlm.nih.gov/32511256/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,28624538,Analysis of mRNA deadenylation by multi-protein complexes.,2017,10.1016/j.ymeth.2017.06.009,https://pubmed.ncbi.nlm.nih.gov/28624538/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,31963662,Transcriptome Modifications in the Porcine Intramuscular Adipocytes during Differentiation and Exogenous Stimulation with TNF-α and Serotonin.,2020,10.3390/ijms21020638,https://pubmed.ncbi.nlm.nih.gov/31963662/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,28579804,Expression of urinary miRNAs targeting NLRs inflammasomes in bladder cancer.,2017,10.2147/ott.s132680,https://pubmed.ncbi.nlm.nih.gov/28579804/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,25502083,Gene expression profile analysis identifies metastasis and chemoresistance-associated genes in epithelial ovarian carcinoma cells.,2015,10.1007/s12032-014-0426-5,https://pubmed.ncbi.nlm.nih.gov/25502083/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,23192004,Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease.,2012,10.1186/1476-9255-9-49,https://pubmed.ncbi.nlm.nih.gov/23192004/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,22761758,Transcriptome analysis during human trophectoderm specification suggests new roles of metabolic and epigenetic genes.,2012,10.1371/journal.pone.0039306,https://pubmed.ncbi.nlm.nih.gov/22761758/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,19020717,Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma.,2008,10.3892/or_00000155,https://pubmed.ncbi.nlm.nih.gov/19020717/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,17785442,"Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation.",2007,10.1128/mcb.01254-07,https://pubmed.ncbi.nlm.nih.gov/17785442/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP4,ENSG00000160505,CTA,8080724,"Evaluation of novel ammine/amine platinum (IV) dicarboxylates in L1210 murine leukaemia cells sensitive and resistant to cisplatin, tetraplatin or carboplatin.",1994,10.1038/bjc.1994.320,https://pubmed.ncbi.nlm.nih.gov/8080724/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP210L,ENSG00000143552,CTA,42548189,A Homozygous NUP210L Variant Is Associated With Severe Defects in Human Spermiogenesis.,2026,10.1111/andr.70330,https://pubmed.ncbi.nlm.nih.gov/42548189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP210L,ENSG00000143552,CTA,42055687,Novel NUP210L Variants Cause Fertilization Failure and Male Infertility in Humans.,2026,10.1111/cge.70175,https://pubmed.ncbi.nlm.nih.gov/42055687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP210L,ENSG00000143552,CTA,41459802,Nucleoporin NUP210L and BAF-paralogue BAF-L redundantly ensure nuclear integrity and manchette microtubule organisation in mouse spermatids.,2026,10.1093/hmg/ddaf194,https://pubmed.ncbi.nlm.nih.gov/41459802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP210L,ENSG00000143552,CTA,42239799,Spatiotemporal patterns of gene expression changes in the mouse dentate gyrus following entorhinal denervation.,2026,10.3389/fnmol.2026.1758390,https://pubmed.ncbi.nlm.nih.gov/42239799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP210L,ENSG00000143552,CTA,38129135,Spermatozoa in mice lacking the nucleoporin NUP210L show defects in head shape and motility but not in nuclear compaction or histone replacement.,2024,10.1111/cge.14468,https://pubmed.ncbi.nlm.nih.gov/38129135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP210L,ENSG00000143552,CTA,42459655,Single-cell atlas of photoaged skin reveals JAK-STAT blockade as a strategy to reverse dermal remodeling.,2026,10.3389/fimmu.2026.1748123,https://pubmed.ncbi.nlm.nih.gov/42459655/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP210L,ENSG00000143552,CTA,38697998,Using genome and transcriptome data from African-ancestry female participants to identify putative breast cancer susceptibility genes.,2024,10.1038/s41467-024-47650-5,https://pubmed.ncbi.nlm.nih.gov/38697998/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP210L,ENSG00000143552,CTA,39147981,DNA Methylation Patterns Associated with Tinnitus in Young Adults-A Pilot Study.,2024,10.1007/s10162-024-00961-2,https://pubmed.ncbi.nlm.nih.gov/39147981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP210L,ENSG00000143552,CTA,37305998,Y-complex nucleoporins independently contribute to nuclear pore assembly and gene regulation in neuronal progenitors.,2023,10.1242/jcs.261151,https://pubmed.ncbi.nlm.nih.gov/37305998/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP210L,ENSG00000143552,CTA,30970224,Epigenetic-genetic chromatin footprinting identifies novel and subject-specific genes active in prefrontal cortex neurons.,2019,10.1096/fj.201802646r,https://pubmed.ncbi.nlm.nih.gov/30970224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP210L,ENSG00000143552,CTA,33332558,Defect in the nuclear pore membrane glycoprotein 210-like gene is associated with extreme uncondensed sperm nuclear chromatin and male infertility: a case report.,2021,10.1093/humrep/deaa329,https://pubmed.ncbi.nlm.nih.gov/33332558/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP210L,ENSG00000143552,CTA,34634379,Overlapping common genetic architecture between major depressive disorders and anxiety and stress-related disorders.,2022,10.1016/j.pnpbp.2021.110450,https://pubmed.ncbi.nlm.nih.gov/34634379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,42459320,Expanding the spectrum of non-canonical NUT carcinoma: clinicopathological and molecular characterization of &lt;i&gt;BRD3::NUTM1&lt;/i&gt; and &lt;i&gt;WWTR1::NUTM1&lt;/i&gt; fusion variants.,2026,10.3389/fonc.2026.1828484,https://pubmed.ncbi.nlm.nih.gov/42459320/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,41644270,Shared PRAME epitopes are T-cell targets in NUT carcinoma.,2026,10.1136/jitc-2025-013539,https://pubmed.ncbi.nlm.nih.gov/41644270/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,42711284,Laryngeal NUT Carcinoma With BRD4::NUTM1 Fusion: A 4-Year Clinical Course Highlighting the Limitations of Current Multimodal Therapy.,2026,10.1002/cnr2.70679,https://pubmed.ncbi.nlm.nih.gov/42711284/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,41590214,Primary Uterine NUT Carcinoma: A Case Report and Literature Review.,2026,10.3390/clinpract16010020,https://pubmed.ncbi.nlm.nih.gov/41590214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,42458680,Adult Erythroblastic Sarcoma With PCM1::JAK2 Fusion and a Novel NOP10::NUTM1 Fusion Complicated by Secondary HLH.,2026,10.1111/jcmm.71286,https://pubmed.ncbi.nlm.nih.gov/42458680/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,41575738,Modeling of Capicua Family Fusion Oncoprotein-Driven Cancers Reveals Gene-Specific Functionality.,2026,10.1158/1541-7786.mcr-25-0624,https://pubmed.ncbi.nlm.nih.gov/41575738/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,42771852,MGA::NUTM1 fusion sarcoma: expanding the spectrum of NUT-rearranged sarcomas with extensive review of the literature.,2026,10.1093/ajcp/aqag101,https://pubmed.ncbi.nlm.nih.gov/42771852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,42870961,Nuclear protein in testis midline carcinoma of nasal cavity: a case report and review of the literature.,2026,10.3389/fonc.2026.1859581,https://pubmed.ncbi.nlm.nih.gov/42870961/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,41373823,Novel &lt;i&gt;NUTM1&lt;/i&gt; Fusions in Relapsed Acute Myeloid Leukemia: Expanding the Genetic and Clinical Landscape.,2025,10.3390/ijms262311676,https://pubmed.ncbi.nlm.nih.gov/41373823/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,41960136,Orbital NUT carcinoma with intracranial extension.,2026,10.1016/j.radcr.2026.02.073,https://pubmed.ncbi.nlm.nih.gov/41960136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,41266112,SOX2 is a dispensable modulator of NUT carcinoma oncogenesis in mice.,2026,10.26508/lsa.202503447,https://pubmed.ncbi.nlm.nih.gov/41266112/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,41001035,Case Report: NUTM1-rearranged lung sarcoma: a rare case imaged with dynamic and static &lt;sup&gt;18&lt;/sup&gt;F-FDG PET/CT.,2025,10.3389/fonc.2025.1663104,https://pubmed.ncbi.nlm.nih.gov/41001035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,41981783,RNA-Sequencing Reveals Two Subgroups of Eccrine Porocarcinomas and Poromas.,2026,10.1111/jcmm.71140,https://pubmed.ncbi.nlm.nih.gov/41981783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,41460961,Comprehensive molecular and functional analysis of NUTM1-rearranged leukemia.,2026,10.1182/blood.2024026928,https://pubmed.ncbi.nlm.nih.gov/41460961/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,41814313,Novel LUC7L::NUTM1 fusion in PDGFRA-rearranged myeloproliferative neoplasm with eosinophilia: a case report.,2026,10.1186/s12957-026-04298-3,https://pubmed.ncbi.nlm.nih.gov/41814313/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,42245706,Primary pulmonary NUT carcinoma with NSD3-NUTM1 fusion treated with dose-escalated adaptive radiotherapy and multimodal therapy: case report.,2026,10.3389/fonc.2026.1827995,https://pubmed.ncbi.nlm.nih.gov/42245706/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,42760727,Nasal NUT carcinoma with repeated responses during multimodal treatment incorporating radiotherapy: A case report.,2026,10.1097/md.0000000000050248,https://pubmed.ncbi.nlm.nih.gov/42760727/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,41816344,Toripalimab-based chemoimmunotherapy for unresectable sinonasal NUT carcinoma of the maxillary sinus: a case report.,2026,10.3389/fimmu.2026.1763340,https://pubmed.ncbi.nlm.nih.gov/41816344/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,42693277,Undifferentiated round cell sarcoma with CIC::NUTM1 fusion: expanding the clinicopathologic spectrum of a rare molecular variant of CIC-rearranged sarcoma.,2026,10.1007/s00428-026-04701-0,https://pubmed.ncbi.nlm.nih.gov/42693277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,42694693,Nuclear Protein in Testis (NUT) Carcinoma: Diagnostic Challenges in a Patient Requiring Rescue Venovenous Extracorporeal Membrane Oxygenation.,2026,10.7759/cureus.113941,https://pubmed.ncbi.nlm.nih.gov/42694693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,42292444,Immune biomarker landscape and fusion partner-phenotype associations in thoracic and head-and-neck NUT carcinoma.,2026,10.3389/fimmu.2026.1834366,https://pubmed.ncbi.nlm.nih.gov/42292444/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,42431551,Tumor Immune Microenvironment and Clinicopathological Characteristics of Thoracic NUT Carcinoma.,2026,10.1016/j.labinv.2026.106153,https://pubmed.ncbi.nlm.nih.gov/42431551/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,40990092,NSD3::NUTM1 fusion evidenced on RNA sequencing in poorly differentiated thyroid cancer: a report of two cases.,2025,10.1530/etj-25-0100,https://pubmed.ncbi.nlm.nih.gov/40990092/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,41754610,Enhanced Antitumor Activity and Induction of Immunogenic Cell Death in NUT Carcinoma Cells by Combining Oncolytic Viruses with the Dual Inhibitor NEO2734.,2026,10.3390/v18020267,https://pubmed.ncbi.nlm.nih.gov/41754610/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,41737331,International guidelines on the diagnosis and treatment of NUT carcinoma.,2026,10.1016/j.xinn.2025.101068,https://pubmed.ncbi.nlm.nih.gov/41737331/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,40884014,A characteristic gene expression profile regulated by ACIN1::NUTM1 fusion in a newly identified infant leukaemic cell line and an ACIN1::NUTM1-inducible model.,2025,10.1111/bjh.70130,https://pubmed.ncbi.nlm.nih.gov/40884014/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,40689944,"YAP1::MAML2, YAP1::NUTM1, and RNF13::PAK2 rearrangements in trichoblastomas and adnexal tumors with panfollicular differentiation: expanding the spectrum of YAP1/PAK-fused skin adnexal tumors.",2025,10.1007/s00428-025-04175-6,https://pubmed.ncbi.nlm.nih.gov/40689944/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,39839761,Case report: Long term remission of metastatic sinonasal NUT carcinoma after palliative radiotherapy and immunotherapy in an elderly patient.,2024,10.3389/fonc.2024.1412070,https://pubmed.ncbi.nlm.nih.gov/39839761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,40704901,Molecular Characterization of NUT Carcinoma: A Report from the NUT Carcinoma Registry.,2025,10.1158/1078-0432.ccr-25-1071,https://pubmed.ncbi.nlm.nih.gov/40704901/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,42582075,Leptomeningeal carcinomatosis in sinonasal NUT carcinoma: a case report and review of intracranial involvement.,2026,10.3389/fonc.2026.1915873,https://pubmed.ncbi.nlm.nih.gov/42582075/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM1,ENSG00000184507,CTA,12543779,BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma.,2003,,https://pubmed.ncbi.nlm.nih.gov/12543779/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OBP2B,ENSG00000171102,CTA,34867304,Emerging Impact of Non-coding RNAs in the Pathology of Stroke.,2021,10.3389/fnagi.2021.780489,https://pubmed.ncbi.nlm.nih.gov/34867304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OBP2B,ENSG00000171102,CTA,37537391,Proteome-wide mendelian randomization identifies causal plasma proteins in venous thromboembolism development.,2023,10.1038/s10038-023-01186-6,https://pubmed.ncbi.nlm.nih.gov/37537391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OBP2B,ENSG00000171102,CTA,39885253,Exploring the role of circulating proteins in multiple myeloma risk: a Mendelian randomization study.,2025,10.1038/s41598-025-86222-5,https://pubmed.ncbi.nlm.nih.gov/39885253/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OBP2B,ENSG00000171102,CTA,33795748,A cell-specific regulatory region of the human ABO blood group gene regulates the neighborhood gene encoding odorant binding protein 2B.,2021,10.1038/s41598-021-86843-6,https://pubmed.ncbi.nlm.nih.gov/33795748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OBP2B,ENSG00000171102,CTA,37895183,Exome-Wide Association Study Identified Clusters of Pleiotropic Genetic Associations with Alzheimer's Disease and Thirteen Cardiovascular Traits.,2023,10.3390/genes14101834,https://pubmed.ncbi.nlm.nih.gov/37895183/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OBP2B,ENSG00000171102,CTA,32793710,Immune-related genes play an important role in the prognosis of patients with testicular germ cell tumor.,2020,10.21037/atm-20-654,https://pubmed.ncbi.nlm.nih.gov/32793710/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OBP2B,ENSG00000171102,CTA,34529670,Identification of key genes and immune infiltration modulated by CPAP in obstructive sleep apnea by integrated bioinformatics analysis.,2021,10.1371/journal.pone.0255708,https://pubmed.ncbi.nlm.nih.gov/34529670/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,42009655,TENT5C extends Odf1 poly(A) tail to sustain sperm morphogenesis and fertility.,2026,10.1038/s41467-026-71953-4,https://pubmed.ncbi.nlm.nih.gov/42009655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,42791710,Transcriptomic Dynamics and ECM Remodeling During Postnatal Testicular Maturation in the Tianzhu White Yak.,2026,10.3390/ani16182853,https://pubmed.ncbi.nlm.nih.gov/42791710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,39386799,"WDR64, a testis-specific protein, is involved in the manchette and flagellum formation by interacting with ODF1.",2024,10.1016/j.heliyon.2024.e38263,https://pubmed.ncbi.nlm.nih.gov/39386799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,39173316,Effect of resveratrol on spermatogenesis in breeding boars and the proteomic analysis for testes.,2024,10.1016/j.repbio.2024.100930,https://pubmed.ncbi.nlm.nih.gov/39173316/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,36142191,Development of the Connecting Piece in ODF1-Deficient Mouse Spermatids.,2022,10.3390/ijms231810280,https://pubmed.ncbi.nlm.nih.gov/36142191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,38038747,CCDC146 is required for sperm flagellum biogenesis and male fertility in mice.,2023,10.1007/s00018-023-05025-x,https://pubmed.ncbi.nlm.nih.gov/38038747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,37371084,Deficiency of the Tmem232 Gene Causes Male Infertility with Morphological Abnormalities of the Sperm Flagellum in Mice.,2023,10.3390/cells12121614,https://pubmed.ncbi.nlm.nih.gov/37371084/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,40211238,LncRNA-mRNA co-expression network in the mechanism of butylphthalide treatment for ischemic stroke.,2025,10.1186/s12883-025-04032-8,https://pubmed.ncbi.nlm.nih.gov/40211238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,31867458,"ODF1, sperm flagelar protein is expressed in kidney collecting ducts of rats.",2019,10.1016/j.heliyon.2019.e02932,https://pubmed.ncbi.nlm.nih.gov/31867458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,31475146,"CCDC42 Localizes to Manchette, HTCA and Tail and Interacts With ODF1 and ODF2 in the Formation of the Male Germ Cell Cytoskeleton.",2019,10.3389/fcell.2019.00151,https://pubmed.ncbi.nlm.nih.gov/31475146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,38265582,Silica nanoparticles induce male reproductive toxicity via Crem hypermethylation mediated spermatocyte apoptosis and sperm flagella damage.,2024,10.1007/s11356-024-32046-1,https://pubmed.ncbi.nlm.nih.gov/38265582/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,35281256,Insights on Human Small Heat Shock Proteins and Their Alterations in Diseases.,2022,10.3389/fmolb.2022.842149,https://pubmed.ncbi.nlm.nih.gov/35281256/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,39506588,Identification of Potential Biomarkers Associated with Spermatogenesis in Azoospermia.,2024,10.7754/clin.lab.2024.240541,https://pubmed.ncbi.nlm.nih.gov/39506588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,37382810,Testicular Toxicity in Rats Exposed to AlCl3: a Proteomics Study.,2024,10.1007/s12011-023-03745-6,https://pubmed.ncbi.nlm.nih.gov/37382810/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,39851555,Key Role of Phosphorylation in Small Heat Shock Protein Regulation via Oligomeric Disaggregation and Functional Activation.,2025,10.3390/cells14020127,https://pubmed.ncbi.nlm.nih.gov/39851555/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,32787870,Effect of transient scrotal hyperthermia on human sperm: an iTRAQ-based proteomic analysis.,2020,10.1186/s12958-020-00640-w,https://pubmed.ncbi.nlm.nih.gov/32787870/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,34336820,Comparative Proteomics and Phosphoproteomics Analysis Reveal the Possible Breed Difference in Yorkshire and Duroc Boar Spermatozoa.,2021,10.3389/fcell.2021.652809,https://pubmed.ncbi.nlm.nih.gov/34336820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,35860846,Novel mutations of PMFBP1 in a man with acephalic spermatozoa defects.,2022,10.1002/mgg3.2020,https://pubmed.ncbi.nlm.nih.gov/35860846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,37511188,Whole Exome Sequencing of 20 Spanish Families: Candidate Genes for Non-Syndromic Pediatric Cataracts.,2023,10.3390/ijms241411429,https://pubmed.ncbi.nlm.nih.gov/37511188/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,36355624,IQUB deficiency causes male infertility by affecting the activity of p-ERK1/2/RSPH3.,2023,10.1093/humrep/deac244,https://pubmed.ncbi.nlm.nih.gov/36355624/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,32973212,Novel targets identified by integrated proteomic and phosphoproteomic analysis in spermatogenesis of swamp buffalo (Bubalus bubalis).,2020,10.1038/s41598-020-72353-4,https://pubmed.ncbi.nlm.nih.gov/32973212/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,24889268,High throughput quantitative reverse transcription PCR assays revealing over-expression of cancer testis antigen genes in multiple myeloma stem cell-like side population cells.,2014,10.1111/bjh.12951,https://pubmed.ncbi.nlm.nih.gov/24889268/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,20682177,"Expression of two testis-specific genes, SPATA19 and LEMD1, in prostate cancer.",2010,10.1016/j.arcmed.2010.04.003,https://pubmed.ncbi.nlm.nih.gov/20682177/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,29168316,Outer dense fibers stabilize the axoneme to maintain sperm motility.,2018,10.1111/jcmm.13457,https://pubmed.ncbi.nlm.nih.gov/29168316/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,23528252,Decreased androgen receptor expression may contribute to spermatogenesis failure in rats exposed to low concentration of bisphenol A.,2013,10.1016/j.toxlet.2013.03.011,https://pubmed.ncbi.nlm.nih.gov/23528252/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,19886887,Elevated expression levels of testis-specific genes TEX101 and SPATA19 in basal cell carcinoma and their correlation with clinical and pathological features.,2010,10.1111/j.1365-2133.2009.09568.x,https://pubmed.ncbi.nlm.nih.gov/19886887/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF1,ENSG00000155087,CTA,23530259,Different anti-aggregation and pro-degradative functions of the members of the mammalian sHSP family in neurological disorders.,2013,10.1098/rstb.2011.0409,https://pubmed.ncbi.nlm.nih.gov/23530259/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF4,ENSG00000184650,CTA,36804949,The association of ODF4 with AK1 and AK2 in mice is essential for fertility through its contribution to flagellar shape.,2023,10.1038/s41598-023-28177-z,https://pubmed.ncbi.nlm.nih.gov/36804949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF4,ENSG00000184650,CTA,39314832,Spermatozoa from male mice with infertility due to &lt;i&gt;Odf4&lt;/i&gt; deficiency can fertilize oocytes by in vitro fertilization.,2024,10.1002/rmb2.12605,https://pubmed.ncbi.nlm.nih.gov/39314832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF4,ENSG00000184650,CTA,36339718,Identification and validation of a novel tumor driver gene signature for diagnosis and prognosis of head and neck squamous cell carcinoma.,2022,10.3389/fmolb.2022.912620,https://pubmed.ncbi.nlm.nih.gov/36339718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF4,ENSG00000184650,CTA,28865418,"ODF4, MAGEA3, and MAGEB4: Potential Biomarkers in Patients with Transitional Cell Carcinoma",2018,10.22034/ibj.22.3.160,https://pubmed.ncbi.nlm.nih.gov/28865418/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF4,ENSG00000184650,CTA,26464818,Upregulation of RHOXF2 and ODF4 Expression in Breast Cancer Tissues.,2015,10.22074/cellj.2015.8,https://pubmed.ncbi.nlm.nih.gov/26464818/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF4,ENSG00000184650,CTA,29058301,Cancer-Testis Antigens as New Candidate Diagnostic Biomarkers for Transitional Cell Carcinoma of Bladder.,2019,10.1007/s12253-017-0313-4,https://pubmed.ncbi.nlm.nih.gov/29058301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF4,ENSG00000184650,CTA,31831960,Detection and analysis of stable and flexible genes towards a genome signature framework in cancer.,2019,10.6026/97320630015772,https://pubmed.ncbi.nlm.nih.gov/31831960/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF4,ENSG00000184650,CTA,22588436,"Expression of testis-specific genes, TEX101 and ODF4, in chronic myeloid leukemia and evaluation of TEX101 immunogenicity.",2012,10.5144/0256-4947.2012.256,https://pubmed.ncbi.nlm.nih.gov/22588436/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF4,ENSG00000184650,CTA,35015293,Histone Methylation Regulates Gene Expression in the Round Spermatids to Set the RNA Payloads of Sperm.,2022,10.1007/s43032-021-00837-3,https://pubmed.ncbi.nlm.nih.gov/35015293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF4,ENSG00000184650,CTA,23096689,Expression of splice variants of cancer-testis genes ODF3 and ODF4 in the testis of a prostate cancer patient.,2012,10.4238/2012.october.4.11,https://pubmed.ncbi.nlm.nih.gov/23096689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF4,ENSG00000184650,CTA,24935380,Lactobacillus acidophilus and Lactobacillus crispatus culture supernatants downregulate expression of cancer-testis genes in the MDA-MB-231 cell line.,2014,10.7314/apjcp.2014.15.10.4255,https://pubmed.ncbi.nlm.nih.gov/24935380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF4,ENSG00000184650,CTA,15270212,"Isolation and expression analysis of the testis-specific gene, human OPPO1.",2004,10.1023/b:jarg.0000029497.30205.cf,https://pubmed.ncbi.nlm.nih.gov/15270212/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF4,ENSG00000184650,CTA,19886887,Elevated expression levels of testis-specific genes TEX101 and SPATA19 in basal cell carcinoma and their correlation with clinical and pathological features.,2010,10.1111/j.1365-2133.2009.09568.x,https://pubmed.ncbi.nlm.nih.gov/19886887/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF4,ENSG00000184650,CTA,20682177,"Expression of two testis-specific genes, SPATA19 and LEMD1, in prostate cancer.",2010,10.1016/j.arcmed.2010.04.003,https://pubmed.ncbi.nlm.nih.gov/20682177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF4,ENSG00000184650,CTA,25197110,"Efficacy of orally disintegrating film of ondansetron versus intravenous ondansetron in prophylaxis of postoperative nausea and vomiting in patients undergoing elective gynaecological laparoscopic procedures: A prospective randomised, double-blind placebo-controlled study.",2014,10.4103/0019-5049.138977,https://pubmed.ncbi.nlm.nih.gov/25197110/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF4,ENSG00000184650,CTA,22015705,"Maternal thimerosal exposure results in aberrant cerebellar oxidative stress, thyroid hormone metabolism, and motor behavior in rat pups; sex- and strain-dependent effects.",2012,10.1007/s12311-011-0319-5,https://pubmed.ncbi.nlm.nih.gov/22015705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF4,ENSG00000184650,CTA,12728016,Molecular cloning and characterization of the human orthologue of the oppo 1 gene encoding a sperm tail protein.,2003,10.1093/molehr/gag030,https://pubmed.ncbi.nlm.nih.gov/12728016/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,41828362,Genetic Mutations and Non-Genomic Dysregulation in Human Preimplantation Embryo Arrest.,2026,10.3390/ijms27052135,https://pubmed.ncbi.nlm.nih.gov/41828362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,38868925,The maternal protein NLRP5 stabilizes UHRF1 in the cytoplasm: implication for the pathogenesis of multilocus imprinting disturbance.,2024,10.1093/hmg/ddae096,https://pubmed.ncbi.nlm.nih.gov/38868925/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,41966403,Probing Proteoform Heterogeneity From Single Human Oocytes.,2026,10.1016/j.mcpro.2026.101566,https://pubmed.ncbi.nlm.nih.gov/41966403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,42201804,Automated Microvolume Secretome Proteomics Enables Sensitive and Deep Profiling and Noninvasive Single-Embryo Analysis.,2026,10.1021/acs.jproteome.6c00284,https://pubmed.ncbi.nlm.nih.gov/42201804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,38091268,Revealing the expression profile of genes that encode the Subcortical Maternal Complex in human reproductive failures.,2023,10.1590/1678-4685-gmb-2023-0141,https://pubmed.ncbi.nlm.nih.gov/38091268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,35946397,Mutations in OOEP and NLRP5 identified in infertile patients with early embryonic arrest.,2022,10.1002/humu.24448,https://pubmed.ncbi.nlm.nih.gov/35946397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,32613414,Subcortical maternal complex (SCMC) expression during folliculogenesis is affected by oocyte donor age in sheep.,2020,10.1007/s10815-020-01871-x,https://pubmed.ncbi.nlm.nih.gov/32613414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,36999055,Expression profiles of meiotic genes in male vs. female gonads and gametes: Insights into fertility issues.,2023,10.3389/fgene.2023.1125097,https://pubmed.ncbi.nlm.nih.gov/36999055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,35365979,Novel multilocus imprinting disturbances in a child with expressive language delay and intellectual disability.,2022,10.1002/ajmg.a.62752,https://pubmed.ncbi.nlm.nih.gov/35365979/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,39178021,"Variants in NLRP2 and ZFP36L2, non-core components of the human subcortical maternal complex, cause female infertility with embryonic development arrest.",2024,10.1093/molehr/gaae031,https://pubmed.ncbi.nlm.nih.gov/39178021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,29955025,Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes.,2018,10.24272/j.issn.2095-8137.2018.067,https://pubmed.ncbi.nlm.nih.gov/29955025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,35296332,Trans-acting genetic variants causing multilocus imprinting disturbance (MLID): common mechanisms and consequences.,2022,10.1186/s13148-022-01259-x,https://pubmed.ncbi.nlm.nih.gov/35296332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,37148315,NLRP7 participates in the human subcortical maternal complex and its variants cause female infertility characterized by early embryo arrest.,2023,10.1007/s00109-023-02322-7,https://pubmed.ncbi.nlm.nih.gov/37148315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,25420964,"Expression of maternally derived KHDC3, NLRP5, OOEP and TLE6 is associated with oocyte developmental competence in the ovine species.",2014,10.1186/s12861-014-0040-y,https://pubmed.ncbi.nlm.nih.gov/25420964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,32915922,One-step automated bioprinting-based method for cumulus-oocyte complex microencapsulation for 3D in vitro maturation.,2020,10.1371/journal.pone.0238812,https://pubmed.ncbi.nlm.nih.gov/32915922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,29396444,Differential long non-coding RNA expression profiles in human oocytes and cumulus cells.,2018,10.1038/s41598-018-20727-0,https://pubmed.ncbi.nlm.nih.gov/29396444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,31575650,The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic lattice formation and organelle distribution.,2019,10.1242/dev.183616,https://pubmed.ncbi.nlm.nih.gov/31575650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,20590823,Maternal-effect gene Ces5/Ooep/Moep19/Floped is essential for oocyte cytoplasmic lattice formation and embryonic development at the maternal-zygotic stage transition.,2010,10.1111/j.1365-2443.2010.01420.x,https://pubmed.ncbi.nlm.nih.gov/20590823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,30797753,Proteomic analysis of mouse ovaries during the prepubertal stages.,2019,10.1016/j.yexcr.2019.02.016,https://pubmed.ncbi.nlm.nih.gov/30797753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOEP,ENSG00000203907,CTA,31201414,"The pivotal roles of the NOD-like receptors with a PYD domain, NLRPs, in oocytes and early embryo development†.",2019,10.1093/biolre/ioz098,https://pubmed.ncbi.nlm.nih.gov/31201414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2H1,ENSG00000204688,CTA,40643465,Exploring OR2H1-Mediated Sperm Chemotaxis: Development and Application of a Novel Microfluidic Device.,2025,10.3390/cells14130944,https://pubmed.ncbi.nlm.nih.gov/40643465/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2H1,ENSG00000204688,CTA,35499393,Olfactory Receptor OR2H1 Is an Effective Target for CAR T Cells in Human Epithelial Tumors.,2022,10.1158/1535-7163.mct-21-0872,https://pubmed.ncbi.nlm.nih.gov/35499393/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2H1,ENSG00000204688,CTA,37227814,Identification and validation of diagnostic signature genes in non-obstructive azoospermia by machine learning.,2023,10.18632/aging.204749,https://pubmed.ncbi.nlm.nih.gov/37227814/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2H1,ENSG00000204688,CTA,23209447,The principal genetic determinants for nasopharyngeal carcinoma in China involve the HLA class I antigen recognition groove.,2012,10.1371/journal.pgen.1003103,https://pubmed.ncbi.nlm.nih.gov/23209447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,42584932,OTUD6A-Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function.,2026,10.1002/advs.77077,https://pubmed.ncbi.nlm.nih.gov/42584932/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,41560298,OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα.,2026,10.1002/advs.202516355,https://pubmed.ncbi.nlm.nih.gov/41560298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,41724787,PRDM1 restricts bladder cancer progression and enhances chemosensitivity by suppressing OTUD6A-mediated deubiquitination of CDC6.,2026,10.1038/s41419-026-08498-3,https://pubmed.ncbi.nlm.nih.gov/41724787/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,42533111,OTUD6A promotes de novo pyrimidine synthesis by deubiquitinating and stabilizing CAD in cervical cancer.,2026,10.1038/s41388-026-03909-3,https://pubmed.ncbi.nlm.nih.gov/42533111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,41685148,OTUD6A drives dopaminergic neuronal degeneration of Parkinson's disease through deubiquitinating ACTG1 in neuronal cells.,2026,10.1016/j.apsb.2025.12.002,https://pubmed.ncbi.nlm.nih.gov/41685148/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,42242445,Microglial OTUD6A promotes neuroinflammation and Alzheimer's disease pathogenesis by deubiquitinating C/EBPβ.,2026,10.1016/j.phrs.2026.108280,https://pubmed.ncbi.nlm.nih.gov/42242445/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,42229000,Expression patterns and proliferative effect of OTUD6A on Sertoli cells and Leydig cells in cattleyak.,2026,10.1016/j.theriogenology.2026.118008,https://pubmed.ncbi.nlm.nih.gov/42229000/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,41122004,Reduced OTUD6A Impairs Spermatogonia Proliferation and Contributes to Spermatogenic Arrest in Cattleyak.,2025,10.1111/rda.70136,https://pubmed.ncbi.nlm.nih.gov/41122004/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,40134118,Otud6a Knockout Leads to Male Subfertility in Mice.,2025,10.1002/mrd.70022,https://pubmed.ncbi.nlm.nih.gov/40134118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,41049752,Deubiquitinase OTUD6A alleviates acetaminophen-induced liver injury by targeting EZH2 to reduce cell death in hepatocytes.,2025,10.1016/j.apsb.2025.06.027,https://pubmed.ncbi.nlm.nih.gov/41049752/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,38685067,Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance.,2024,10.1186/s12943-024-01996-y,https://pubmed.ncbi.nlm.nih.gov/38685067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,41050073,Deubiquitinating Enzyme OTUDs: Focus on Cancers and Antiviral Response.,2025,10.32604/or.2025.063644,https://pubmed.ncbi.nlm.nih.gov/41050073/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,37632103,Deubiquitinase OTUD6A Regulates Innate Immune Response via Targeting UBC13.,2023,10.3390/v15081761,https://pubmed.ncbi.nlm.nih.gov/37632103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,38342418,Deubiquitinase OTUD6a drives cardiac inflammation and hypertrophy by deubiquitination of STING.,2024,10.1016/j.bbadis.2024.167061,https://pubmed.ncbi.nlm.nih.gov/38342418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,38594215,OTUD6A orchestrates complex modulation of TEAD4-mediated transcriptional programs.,2024,10.1002/1873-3468.14861,https://pubmed.ncbi.nlm.nih.gov/38594215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,36932155,Deubiquitinase OTUD6A in macrophages promotes intestinal inflammation and colitis via deubiquitination of NLRP3.,2023,10.1038/s41418-023-01148-7,https://pubmed.ncbi.nlm.nih.gov/36932155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,38105755,OTUD6A in tubular epithelial cells mediates angiotensin II-induced kidney injury by targeting STAT3.,2024,10.1152/ajpcell.00394.2023,https://pubmed.ncbi.nlm.nih.gov/38105755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,35217790,Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc.,2022,10.1038/s41418-022-00960-x,https://pubmed.ncbi.nlm.nih.gov/35217790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,35768646,Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy.,2022,10.1038/s41418-022-01036-6,https://pubmed.ncbi.nlm.nih.gov/35768646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD6A,ENSG00000189401,CTA,35233061,OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR.,2022,10.1038/s42003-022-03133-1,https://pubmed.ncbi.nlm.nih.gov/35233061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE1,ENSG00000068985,CTA,42289540,Hypoxia-driven transcriptional activation of MIR100HG by HIF-1α contributes to adaptive gene regulation in hepatocellular carcinoma.,2026,10.1007/s10142-026-01899-9,https://pubmed.ncbi.nlm.nih.gov/42289540/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE1,ENSG00000068985,CTA,38450186,Humoral immunoprofiling identifies novel biomarkers and an immune suppressive autoantibody phenotype at the site of disease in pancreatic ductal adenocarcinoma.,2024,10.3389/fonc.2024.1330419,https://pubmed.ncbi.nlm.nih.gov/38450186/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE1,ENSG00000068985,CTA,37341056,Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer.,2023,10.1002/1878-0261.13474,https://pubmed.ncbi.nlm.nih.gov/37341056/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE1,ENSG00000068985,CTA,38649860,m1A regulator-mediated methylation modification patterns correlated with autophagy to predict the prognosis of hepatocellular carcinoma.,2024,10.1186/s12885-024-12235-4,https://pubmed.ncbi.nlm.nih.gov/38649860/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE1,ENSG00000068985,CTA,38054921,Development and evaluation of a risk score model based on a WNT score gene-associated signature for predicting the clinical outcome and the tumour microenvironment of hepatocellular carcinoma.,2023,10.1177/03946320231218179,https://pubmed.ncbi.nlm.nih.gov/38054921/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE1,ENSG00000068985,CTA,35622212,Identification of a seven-gene signature predicting clinical outcome of liver cancer based on tumor mutational burden.,2022,10.1007/s13577-022-00708-2,https://pubmed.ncbi.nlm.nih.gov/35622212/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE1,ENSG00000068985,CTA,18088181,A radiation-induced gene signature distinguishes post-Chernobyl from sporadic papillary thyroid cancers.,2007,10.1667/rr0968.1,https://pubmed.ncbi.nlm.nih.gov/18088181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE1,ENSG00000068985,CTA,28074109,"Improvement of quality of life through glycemic control by liraglutide, a GLP-1 analog, in insulin-naive patients with type 2 diabetes mellitus: the PAGE1 study.",2017,10.1186/s13098-016-0202-0,https://pubmed.ncbi.nlm.nih.gov/28074109/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE1,ENSG00000068985,CTA,9483158,Implications of socio-cultural contexts for the ethics of clinical trials.,1997,,https://pubmed.ncbi.nlm.nih.gov/9483158/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE2,ENSG00000234068,CTA,41091706,"A survey of human cancer-germline genes: Linking X chromosome localization, DNA methylation and sex-biased expression in early embryos.",2025,10.1371/journal.pgen.1011734,https://pubmed.ncbi.nlm.nih.gov/41091706/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE2,ENSG00000234068,CTA,25229454,"Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2, -2B and SPANX-B, during mesenchymal-to-epithelial transition.",2014,10.1371/journal.pone.0107905,https://pubmed.ncbi.nlm.nih.gov/25229454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE2,ENSG00000234068,CTA,28742074,Untargeted screening for novel autoantibodies with prognostic value in first-episode psychosis.,2017,10.1038/tp.2017.160,https://pubmed.ncbi.nlm.nih.gov/28742074/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE2,ENSG00000234068,CTA,12761064,ProPred1: prediction of promiscuous MHC Class-I binding sites.,2003,10.1093/bioinformatics/btg108,https://pubmed.ncbi.nlm.nih.gov/12761064/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,37529004,Cancer testis antigen PASD1 expression and immunogenicity in human colorectal cancer and polyps.,2022,10.55730/1300-0152.2623,https://pubmed.ncbi.nlm.nih.gov/37529004/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,37057240,Identification of Cancer/Testis Antigens Related to Gastric Cancer Prognosis Based on Co-Expression Network and Integrated Transcriptome Analyses.,2023,10.4103/abr.abr_400_21,https://pubmed.ncbi.nlm.nih.gov/37057240/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,31558691,PAS Domain Containing Repressor 1 (PASD1) Promotes Glioma Cell Proliferation Through Inhibiting Apoptosis In Vitro.,2019,10.12659/msm.916308,https://pubmed.ncbi.nlm.nih.gov/31558691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,31478431,Validation of immunogenic PASD1 peptides against HLA-A*24:02 colorectal cancer.,2019,10.2217/imt-2019-0073,https://pubmed.ncbi.nlm.nih.gov/31478431/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,33290900,Biological features of tissue and bone sarcomas investigated using an in vitro model of clonal selection.,2021,10.1016/j.prp.2020.153214,https://pubmed.ncbi.nlm.nih.gov/33290900/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,25936801,Cancer/Testis Antigen PASD1 Silences the Circadian Clock.,2015,10.1016/j.molcel.2015.03.031,https://pubmed.ncbi.nlm.nih.gov/25936801/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,26327782,"Infrequent Expression of the Cancer-Testis Antigen, PASD1, in Ovarian Cancer.",2015,10.4137/bic.s28378,https://pubmed.ncbi.nlm.nih.gov/26327782/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,26892021,PASD1 promotes STAT3 activity and tumor growth by inhibiting TC45-mediated dephosphorylation of STAT3 in the nucleus.,2016,10.1093/jmcb/mjw005,https://pubmed.ncbi.nlm.nih.gov/26892021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,35651938,Identification of Novel Characteristics in TP53-Mutant Hepatocellular Carcinoma Using Bioinformatics.,2022,10.3389/fgene.2022.874805,https://pubmed.ncbi.nlm.nih.gov/35651938/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,23882161,An analogue peptide from the Cancer/Testis antigen PASD1 induces CD8+ T cell responses against naturally processed peptide.,2013,,https://pubmed.ncbi.nlm.nih.gov/23882161/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,20851862,CD4-positive T-helper cell responses to the PASD1 protein in patients with diffuse large B-cell lymphoma.,2011,10.3324/haematol.2010.028241,https://pubmed.ncbi.nlm.nih.gov/20851862/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,20726502,A panel of cancer-testis genes exhibiting broad-spectrum expression in haematological malignancies.,2010,,https://pubmed.ncbi.nlm.nih.gov/20726502/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,26492414,Application of the pMHC Array to Characterise Tumour Antigen Specific T Cell Populations in Leukaemia Patients at Disease Diagnosis.,2015,10.1371/journal.pone.0140483,https://pubmed.ncbi.nlm.nih.gov/26492414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,20861911,DNA vaccines to target the cancer testis antigen PASD1 in human multiple myeloma.,2010,10.1038/leu.2010.196,https://pubmed.ncbi.nlm.nih.gov/20861911/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,19552722,Cytolytic T-cell response to the PASD1 cancer testis antigen in patients with diffuse large B-cell lymphoma.,2009,10.1111/j.1365-2141.2009.07761.x,https://pubmed.ncbi.nlm.nih.gov/19552722/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,15162151,A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein.,2004,10.1038/sj.bjc.6601875,https://pubmed.ncbi.nlm.nih.gov/15162151/,annotation citations | normal | therapy,Discussed in explicit gene adjudication; see its review depth and limitations
PASD1,ENSG00000166049,CTA,16112646,Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia.,2005,10.1016/j.bbrc.2005.08.024,https://pubmed.ncbi.nlm.nih.gov/16112646/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,19886887,Elevated expression levels of testis-specific genes TEX101 and SPATA19 in basal cell carcinoma and their correlation with clinical and pathological features.,2010,10.1111/j.1365-2133.2009.09568.x,https://pubmed.ncbi.nlm.nih.gov/19886887/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,17024112,"PASD1, a DLBCL-associated cancer testis antigen and candidate for lymphoma immunotherapy.",2006,10.1038/sj.leu.2404424,https://pubmed.ncbi.nlm.nih.gov/17024112/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PASD1,ENSG00000166049,CTA,22560555,The abscopal effect associated with a systemic anti-melanoma immune response.,2013,10.1016/j.ijrobp.2012.03.017,https://pubmed.ncbi.nlm.nih.gov/22560555/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PATE2,ENSG00000196844,CTA,39682151,"Multiple Myeloma Cells with Increased Proteasomal and ER Stress Are Hypersensitive to ATX-101, an Experimental Peptide Drug Targeting PCNA.",2024,10.3390/cancers16233963,https://pubmed.ncbi.nlm.nih.gov/39682151/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PATE2,ENSG00000196844,CTA,30927342,Nine genes abundantly expressed in the epididymis are not essential for male fecundity in mice.,2019,10.1111/andr.12621,https://pubmed.ncbi.nlm.nih.gov/30927342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PATE2,ENSG00000196844,CTA,18387948,"PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity.",2008,10.1074/jbc.m801454200,https://pubmed.ncbi.nlm.nih.gov/18387948/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
PATE3,ENSG00000236027,CTA,30927342,Nine genes abundantly expressed in the epididymis are not essential for male fecundity in mice.,2019,10.1111/andr.12621,https://pubmed.ncbi.nlm.nih.gov/30927342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PATE3,ENSG00000236027,CTA,18387948,"PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity.",2008,10.1074/jbc.m801454200,https://pubmed.ncbi.nlm.nih.gov/18387948/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,40875569,"Effects of Quercetin on Palladium Chloride-Induced Endoplasmic Reticulum Stress, Inflammation, Oxidative Stress, and Apoptosis in Hepatorenal Tissues.",2025,10.1093/mam/ozaf077,https://pubmed.ncbi.nlm.nih.gov/40875569/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,37554526,Identification of PDCL2 as a candidate marker in Sertoli cell-only syndrome by chromatin immunoprecipitation-sequencing and bioinformatics analysis.,2023,10.21037/tau-23-304,https://pubmed.ncbi.nlm.nih.gov/37554526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,36278277,PDCL2 is essential for sperm acrosome formation and male fertility in mice.,2023,10.1111/andr.13329,https://pubmed.ncbi.nlm.nih.gov/36278277/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,36253364,PDCL2 is essential for spermiogenesis and male fertility in mice.,2022,10.1038/s41420-022-01210-2,https://pubmed.ncbi.nlm.nih.gov/36253364/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,39126002,Quantitative Proteomic Analysis Reveals Key Proteins Involved in Testicular Development of Yaks.,2024,10.3390/ijms25158433,https://pubmed.ncbi.nlm.nih.gov/39126002/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,36462395,"Characterization of SPINK2, SPACA7 and PDCL2: Effect of immunization on fecundity, sperm function and testicular transcriptome.",2023,10.1016/j.repbio.2022.100711,https://pubmed.ncbi.nlm.nih.gov/36462395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,42446730,"Exploring NiCl&lt;sub&gt;2&lt;/sub&gt;, PdCl&lt;sub&gt;2&lt;/sub&gt; and PtCl&lt;sub&gt;2&lt;/sub&gt; as a catalyst for [3 + 2] cycloaddition in Kopsane alkaloid synthesis by density functional theory study.",2026,10.1007/s00044-026-03556-z,https://pubmed.ncbi.nlm.nih.gov/42446730/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,33426787,Combined RNA/tissue profiling identifies novel Cancer/testis genes.,2021,10.1002/1878-0261.12900,https://pubmed.ncbi.nlm.nih.gov/33426787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,42002563,Synthesis and multipurpose assessment of Cu(II) and Pd(II) Schiff base complexes as catalysts and antimicrobial agents.,2026,10.1038/s41598-026-47355-3,https://pubmed.ncbi.nlm.nih.gov/42002563/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,36209044,Advancing ASMS with LC-MS/MS for the discovery of novel PDCL2 ligands from DNA-encoded chemical library selections.,2023,10.1111/andr.13309,https://pubmed.ncbi.nlm.nih.gov/36209044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,42382292,Bandage-Type Autocatalytic PdCl&lt;sub&gt;2&lt;/sub&gt;‑Containing Film as Visual Hydrogen Sensor for Noninvasive Monitoring of Mg-Alloy Biodegradation.,2026,10.1021/acsaom.6c00202,https://pubmed.ncbi.nlm.nih.gov/42382292/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,34438721,Identification and Characterization of lncRNA and mRNA in Testes of Landrace and Hezuo Boars.,2021,10.3390/ani11082263,https://pubmed.ncbi.nlm.nih.gov/34438721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,34027534,"Role of π-conjugation on the coordination behaviour, substitution kinetics, DNA/BSA interactions, and in vitro cytotoxicity of carboxamide palladium(II) complexes.",2021,10.1039/d1dt00412c,https://pubmed.ncbi.nlm.nih.gov/34027534/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,25133960,"A new library of arsine, stibine-stabilized N-heterocyclic carbene palladium complexes: synthesis, structures and activities in C-C and C-N coupling reactions.",2014,10.1039/c4dt01773k,https://pubmed.ncbi.nlm.nih.gov/25133960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,24671375,"Dinuclear NHC-palladium complexes containing phosphine spacers: synthesis, X-ray structures and their catalytic activities towards the Hiyama coupling reaction.",2014,10.1039/c4dt00180j,https://pubmed.ncbi.nlm.nih.gov/24671375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,23672493,"Anti-cancer effects of newly developed chemotherapeutic agent, glycoconjugated palladium (II) complex, against cisplatin-resistant gastric cancer cells.",2013,10.1186/1471-2407-13-237,https://pubmed.ncbi.nlm.nih.gov/23672493/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,20003220,RFX2 is a candidate downstream amplifier of A-MYB regulation in mouse spermatogenesis.,2009,10.1186/1471-213x-9-63,https://pubmed.ncbi.nlm.nih.gov/20003220/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,26346620,Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation.,2015,10.1038/srep13632,https://pubmed.ncbi.nlm.nih.gov/26346620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,25213875,"Gas-liquid interface-mediated room-temperature synthesis of ""clean"" PdNiP alloy nanoparticle networks with high catalytic activity for ethanol oxidation.",2014,10.1039/c4cc06026a,https://pubmed.ncbi.nlm.nih.gov/25213875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,26396867,"Crystal structure of [N,N'-bis-(4-methyl-phen-yl)-1,2-di-phenyl-ethane-1,2-di-imine-κ(2) N,N']di-chlorido-palladium(II) methanol monosolvate.",2015,10.1107/s2056989015014851,https://pubmed.ncbi.nlm.nih.gov/26396867/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,40492372,Shifting Acetylene Hydrochlorination From the Gas to the Liquid Phase: Vinyl Chloride Production in Bichloride-Based Ionic Liquids.,2025,10.1002/advs.202503992,https://pubmed.ncbi.nlm.nih.gov/40492372/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,22420545,Toxic effects of palladium compounds on the isolated rat heart.,2012,10.2174/157340612799278612,https://pubmed.ncbi.nlm.nih.gov/22420545/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,30074367,[A Facile Nanogold Surface Plasmon Resonance Absorption Method for CO Tracing].,2016,,https://pubmed.ncbi.nlm.nih.gov/30074367/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,35539195,Highly efficient and recyclable water-soluble fullerene-supported PdCl2 nanocatalyst in Suzuki-Miyaura cross-coupling reaction.,2018,10.1039/c8ra03754j,https://pubmed.ncbi.nlm.nih.gov/35539195/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,24362086,Impact of platinum group elements on the soil invertebrate Folsomia candida.,2013,,https://pubmed.ncbi.nlm.nih.gov/24362086/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,24853715,A simple hydrophilic palladium(II) complex as a highly efficient catalyst for room temperature aerobic Suzuki coupling reactions in aqueous media.,2014,10.3390/molecules19056524,https://pubmed.ncbi.nlm.nih.gov/24853715/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,23786413,Potential anticancer heterometallic Fe-Au and Fe-Pd agents: initial mechanistic insights.,2013,10.1021/jm4007615,https://pubmed.ncbi.nlm.nih.gov/23786413/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,25610346,Antioxidant enzyme inhibitor role of phosphine metal complexes in lung and leukemia cell lines.,2014,10.1155/2014/717421,https://pubmed.ncbi.nlm.nih.gov/25610346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,17168585,Suzuki-Miyaura cross-coupling reactions of potassium vinyltrifluoroborate with aryl and heteroaryl electrophiles.,2006,10.1021/jo0617013,https://pubmed.ncbi.nlm.nih.gov/17168585/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,18482439,"Nickel, palladium and rhodium induced IFN-gamma and IL-10 production as assessed by in vitro ELISpot-analysis in contact dermatitis patients.",2008,10.1186/1471-2172-9-19,https://pubmed.ncbi.nlm.nih.gov/18482439/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,10901302,Photosensitizing properties of palladium-tetraphenylporphycene on cultured tumour cells.,2000,,https://pubmed.ncbi.nlm.nih.gov/10901302/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,50942,Preliminary studies on the toxicity and metabolism of palladium and platinum.,1975,10.1289/ehp.751063,https://pubmed.ncbi.nlm.nih.gov/50942/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDCL2,ENSG00000163440,CTA,1119851,"Dermal irritancy of metal compounds. Studies with palladium, platinum, lead, and manganese compounds.",1975,10.1080/00039896.1975.10666669,https://pubmed.ncbi.nlm.nih.gov/1119851/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,41639206,Integrative bioinformatics analyses of mitochondrial dysfunction-related genes in human non-obstructive azoospermia.,2026,10.1038/s41598-026-38077-7,https://pubmed.ncbi.nlm.nih.gov/41639206/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,40679056,Compensation for X-linked Pdha1 silencing by Pdha2 is essential for meiotic double-strand break repair in spermatogenesis.,2025,10.1242/dev.204683,https://pubmed.ncbi.nlm.nih.gov/40679056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,41082659,Sperm and offspring production in a nonobstructive azoospermia mouse model via testicular mRNA delivery using lipid nanoparticles.,2025,10.1073/pnas.2516573122,https://pubmed.ncbi.nlm.nih.gov/41082659/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,41153950,Metabolomics Reveals Abnormal Citrate Cycle and Phenylalanine Metabolism in Testes from Infertile Hybrid Dzo.,2025,10.3390/ani15203023,https://pubmed.ncbi.nlm.nih.gov/41153950/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,39973374,Testis-Specific PDHA2 Is Required for Proper Meiotic Recombination and Chromosome Organisation During Spermatogenesis.,2025,10.1111/cpr.70003,https://pubmed.ncbi.nlm.nih.gov/39973374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,40772621,The people behind the papers - Chen Pan and Keisuke Shimada.,2025,10.1242/dev.205120,https://pubmed.ncbi.nlm.nih.gov/40772621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,39729915,Analyses of widely targeted metabolic profiling reveal enhanced energy metabolism in well-developed testicular tissue of Hu sheep.,2025,10.1016/j.domaniend.2024.106909,https://pubmed.ncbi.nlm.nih.gov/39729915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,39308831,Population structure and selective signature of Kirghiz sheep by Illumina Ovine SNP50 BeadChip.,2024,10.7717/peerj.17980,https://pubmed.ncbi.nlm.nih.gov/39308831/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,35172124,Whole-exome sequencing improves the diagnosis and care of men with non-obstructive azoospermia.,2022,10.1016/j.ajhg.2022.01.011,https://pubmed.ncbi.nlm.nih.gov/35172124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,37265843,Transcriptome and co-expression network analysis reveals the molecular mechanism of inosine monophosphate-specific deposition in chicken muscle.,2023,10.3389/fphys.2023.1199311,https://pubmed.ncbi.nlm.nih.gov/37265843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,37508616,Innovative Family-Based Genetically Informed Series of Analyses of Whole-Exome Data Supports Likely Inheritance for Grammar in Children with Specific Language Impairment.,2023,10.3390/children10071119,https://pubmed.ncbi.nlm.nih.gov/37508616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,27343776,Complex genetic findings in a female patient with pyruvate dehydrogenase complex deficiency: Null mutations in the PDHX gene associated with unusual expression of the testis-specific PDHA2 gene in her somatic cells.,2016,10.1016/j.gene.2016.06.041,https://pubmed.ncbi.nlm.nih.gov/27343776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,27656664,Data supporting the co-expression of PDHA1 gene and of its paralogue PDHA2 in somatic cells of a family.,2016,10.1016/j.dib.2016.08.029,https://pubmed.ncbi.nlm.nih.gov/27656664/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,34163562,Pairwise correlation of genes involved in glucose metabolism: a potential diagnostic marker of cancer?,2021,10.18632/genesandcancer.216,https://pubmed.ncbi.nlm.nih.gov/34163562/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,22675509,Demethylation of the coding region triggers the activation of the human testis-specific PDHA2 gene in somatic tissues.,2012,10.1371/journal.pone.0038076,https://pubmed.ncbi.nlm.nih.gov/22675509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,34096088,Moderate endurance training reduced hepatic tumourigenesis associated with lower lactate overload compared to high-intensity interval training.,2021,10.1111/1440-1681.13536,https://pubmed.ncbi.nlm.nih.gov/34096088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,29581481,Linked homozygous BMPR1B and PDHA2 variants in a consanguineous family with complex digit malformation and male infertility.,2018,10.1038/s41431-018-0121-7,https://pubmed.ncbi.nlm.nih.gov/29581481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,22750801,Pyruvate dehydrogenase complex: mRNA and protein expression patterns of E1α subunit genes in human spermatogenesis.,2012,10.1016/j.gene.2012.06.068,https://pubmed.ncbi.nlm.nih.gov/22750801/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDHA2,ENSG00000163114,CTA,32357196,Effect of 8-week of dietary micronutrient supplementation on gene expression in elite handball athletes.,2020,10.1371/journal.pone.0232237,https://pubmed.ncbi.nlm.nih.gov/32357196/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDZD9,ENSG00000155714,CTA,35079800,Transcriptome analyses indicate that heat stress-induced inflammation in white adipose tissue and oxidative stress in skeletal muscle is partially moderated by zilpaterol supplementation in beef cattle.,2022,10.1093/jas/skac019,https://pubmed.ncbi.nlm.nih.gov/35079800/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,41668650,Actin-related protein T3 is required for acrosome biogenesis and sperm function in mice.,2026,10.1242/dev.205283,https://pubmed.ncbi.nlm.nih.gov/41668650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,34869336,"Loss of Profilin3 Impairs Spermiogenesis by Affecting Acrosome Biogenesis, Autophagy, Manchette Development and Mitochondrial Organization.",2021,10.3389/fcell.2021.749559,https://pubmed.ncbi.nlm.nih.gov/34869336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,35202092,Interdependent Transcription of a Natural Sense/Antisense Transcripts Pair (SLC34A1/PFN3).,2022,10.3390/ncrna8010019,https://pubmed.ncbi.nlm.nih.gov/35202092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,33775850,Profilin 3 genetic architecture in glioma formalin fixed paraffin embedded (FFPE) archive.,2021,10.1016/j.gene.2021.145614,https://pubmed.ncbi.nlm.nih.gov/33775850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,36223009,Effects of oocyte vitrification on gene expression in the liver and kidney tissues of adult offspring.,2022,10.1007/s10815-022-02611-z,https://pubmed.ncbi.nlm.nih.gov/36223009/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,27185630,Distribution analysis of profilin isoforms at transcript resolution with mRNA-seq and secondary structure in various organs of Rattus norvegicus.,2016,10.1016/j.gene.2016.05.023,https://pubmed.ncbi.nlm.nih.gov/27185630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,27241791,Natural antisense transcription from a comparative perspective.,2016,10.1016/j.ygeno.2016.05.004,https://pubmed.ncbi.nlm.nih.gov/27241791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,34584637,"MXD3 as an onco-immunological biomarker encompassing the tumor microenvironment, disease staging, prognoses, and therapeutic responses in multiple cancer types.",2021,10.1016/j.csbj.2021.08.047,https://pubmed.ncbi.nlm.nih.gov/34584637/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,33381555,"cg04448376, cg24387542, cg08548498, and cg14621323 as a Novel Signature to Predict Prognosis in Kidney Renal Papillary Cell Carcinoma.",2020,10.1155/2020/4854390,https://pubmed.ncbi.nlm.nih.gov/33381555/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,19419568,Testis-expressed profilins 3 and 4 show distinct functional characteristics and localize in the acroplaxome-manchette complex in spermatids.,2009,10.1186/1471-2121-10-34,https://pubmed.ncbi.nlm.nih.gov/19419568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,19237395,Strand selective generation of endo-siRNAs from the Na/phosphate transporter gene Slc34a1 in murine tissues.,2009,10.1093/nar/gkp088,https://pubmed.ncbi.nlm.nih.gov/19237395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,21626087,Potential forensic application of DNA methylation profiling to body fluid identification.,2012,10.1007/s00414-011-0569-2,https://pubmed.ncbi.nlm.nih.gov/21626087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,24052059,Body fluid identification by integrated analysis of DNA methylation and body fluid-specific microbial DNA.,2014,10.1007/s00414-013-0918-4,https://pubmed.ncbi.nlm.nih.gov/24052059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,22396660,"A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1.",2012,10.1371/journal.pgen.1002541,https://pubmed.ncbi.nlm.nih.gov/22396660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,22653424,DNA methylation-specific multiplex assays for body fluid identification.,2013,10.1007/s00414-012-0719-1,https://pubmed.ncbi.nlm.nih.gov/22653424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,11867228,Genomic organization of profilin-III and evidence for a transcript expressed exclusively in testis.,2002,10.1016/s0378-1119(01)00855-1,https://pubmed.ncbi.nlm.nih.gov/11867228/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,11549015,Heterologous expression of the Bacillus pumilus endo-beta-xylanase (xynA) gene in the yeast Saccharomyces cerevisiae.,2001,10.1007/s002530100670,https://pubmed.ncbi.nlm.nih.gov/11549015/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,8771785,Arabidopsis profilins are functionally similar to yeast profilins: identification of a vascular bundle-specific profilin and a pollen-specific profilin.,1996,10.1046/j.1365-313x.1996.10020269.x,https://pubmed.ncbi.nlm.nih.gov/8771785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN3,ENSG00000196570,CTA,17668047,Genome sequence of Fusobacterium nucleatum subspecies polymorphum - a genetically tractable fusobacterium.,2007,10.1371/journal.pone.0000659,https://pubmed.ncbi.nlm.nih.gov/17668047/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,42256217,Gut &lt;i&gt;Bacteroidales&lt;/i&gt; and AMH/INH-B ratio predict sperm retrieval: mechanistic insights via SCFA-mediated regulation of blood-testis barrier and steroidogenesis.,2026,10.3389/fcimb.2026.1777930,https://pubmed.ncbi.nlm.nih.gov/42256217/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,41192556,Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.,2025,10.1016/j.mcpro.2025.101439,https://pubmed.ncbi.nlm.nih.gov/41192556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,41992955,PINK1‑mediated mitophagy enhances breast cancer proliferation through metabolic reprogramming.,2026,10.3892/or.2026.9117,https://pubmed.ncbi.nlm.nih.gov/41992955/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,42127530,Testicular cryopreservation of prepubertal and adult Morada Nova rams: Slow freezing versus vitrification.,2026,10.1016/j.anireprosci.2026.108227,https://pubmed.ncbi.nlm.nih.gov/42127530/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,40114829,Seminal plasma PGK2 serves as a predictive biomarker for post-varicocelectomy sperm motility improvement in varicocele subjects.,2025,10.21037/tau-24-629,https://pubmed.ncbi.nlm.nih.gov/40114829/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,41640862,Carbohydrate metabolism and phosphorylation cascades regulate flavor formation in chicken meat.,2026,10.1016/j.fochms.2026.100361,https://pubmed.ncbi.nlm.nih.gov/41640862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,40570454,"Tea polyphenols: Effects on growth, immune function, and reproductive performance of roosters.",2025,10.1016/j.psj.2025.105449,https://pubmed.ncbi.nlm.nih.gov/40570454/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,39996768,Generation of a Transgenic Mouse Model for Investigating Mitochondria in Sperm.,2025,10.3390/cells14040296,https://pubmed.ncbi.nlm.nih.gov/39996768/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,42381517,Proteomic Profiling of Cryopreservation-Induced Alterations in Rhesus Macaque Sperm.,2026,10.1111/andr.70303,https://pubmed.ncbi.nlm.nih.gov/42381517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,38654926,Proteomic biomarkers in seminal plasma as predictors of reproductive potential in azoospermic men.,2024,10.3389/fendo.2024.1327800,https://pubmed.ncbi.nlm.nih.gov/38654926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,38668519,Decreased Ubiquitination and Acetylation of Histones 3 and 4 Are Associated with Obesity-Induced Disorders of Spermatogenesis in Mice.,2024,10.3390/toxics12040296,https://pubmed.ncbi.nlm.nih.gov/38668519/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,39509399,Isoscopoletin inhibits hepatocellular carcinoma cell proliferation via regulating glycolysis-related proteins.,2024,10.1371/journal.pone.0310530,https://pubmed.ncbi.nlm.nih.gov/39509399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,40783785,METTL5 deficiency induces oligoasthenoteratozoospermia via impaired 18S rRNA m&lt;sup&gt;6&lt;/sup&gt;A methylation in humans and mice.,2025,10.1016/j.ymthe.2025.08.009,https://pubmed.ncbi.nlm.nih.gov/40783785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,37224707,Effects of melatonin on a d-galactose-induced male reproductive aging mouse model.,2023,10.1016/j.theriogenology.2023.05.001,https://pubmed.ncbi.nlm.nih.gov/37224707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,35930251,Evaluation of PGK2 and ACR proteins in seminal plasma: suggestion of potential new biomarkers for prediction of sperm retrieval in non-obstructive azoospermia patients.,2023,10.1080/14647273.2022.2104136,https://pubmed.ncbi.nlm.nih.gov/35930251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,33507524,The Germ Cell-Specific Markers ZPBP2 and PGK2 in Testicular Biopsies Can Predict the Presence as well as the Quality of Sperm in Non-obstructive Azoospermia Patients.,2021,10.1007/s43032-020-00427-9,https://pubmed.ncbi.nlm.nih.gov/33507524/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,35096946,Combined Analysis of Gut Microbiota and Plasma Metabolites Reveals the Effect of Red-Fleshed Apple Anthocyanin Extract on Dysfunction of Mice Reproductive System Induced by Busulfan.,2021,10.3389/fnut.2021.802352,https://pubmed.ncbi.nlm.nih.gov/35096946/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,38275411,The Role of Chorein Deficiency in Late Spermatogenesis.,2024,10.3390/biomedicines12010240,https://pubmed.ncbi.nlm.nih.gov/38275411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,35148224,Peptides from the croceine croaker (Larimichthys crocea) swim bladder attenuate busulfan-induced oligoasthenospermia in mice.,2022,10.1080/13880209.2022.2034895,https://pubmed.ncbi.nlm.nih.gov/35148224/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,40716245,Systematic review and evidence-based classification of differentially expressed mRNA in human spermatozoa: insights to improve the diagnosis and prognosis of male infertility.,2025,10.1016/j.rbmo.2025.104993,https://pubmed.ncbi.nlm.nih.gov/40716245/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,36449552,Two apicoplast dwelling glycolytic enzymes provide key substrates for metabolic pathways in the apicoplast and are critical for Toxoplasma growth.,2022,10.1371/journal.ppat.1011009,https://pubmed.ncbi.nlm.nih.gov/36449552/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,36133460,Magnetic nanoparticle mediated-gene delivery for simpler and more effective transformation of Pichia pastoris.,2021,10.1039/d1na00079a,https://pubmed.ncbi.nlm.nih.gov/36133460/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,32991915,The ubiquitination and acetylation of histones are associated with male reproductive disorders induced by chronic exposure to arsenite.,2020,10.1016/j.taap.2020.115253,https://pubmed.ncbi.nlm.nih.gov/32991915/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,36692643,Metabolic heterogeneity in early-stage lung adenocarcinoma revealed by RNA-seq and scRNA-seq.,2023,10.1007/s12094-023-03082-z,https://pubmed.ncbi.nlm.nih.gov/36692643/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,32292350,"Esculetin Inhibits Cancer Cell Glycolysis by Binding Tumor PGK2, GPD2, and GPI.",2020,10.3389/fphar.2020.00379,https://pubmed.ncbi.nlm.nih.gov/32292350/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,31472347,Arsenic influences spermatogenesis by disorganizing the elongation of spermatids in adult male mice.,2020,10.1016/j.chemosphere.2019.124650,https://pubmed.ncbi.nlm.nih.gov/31472347/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,33438283,Identification of abnormal protein expressions associated with mouse spermatogenesis induced by cyclophosphamide.,2021,10.1111/jcmm.16263,https://pubmed.ncbi.nlm.nih.gov/33438283/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,36761693,Identification of microtubule-associated biomarkers in diffuse large B-cell lymphoma and prognosis prediction.,2022,10.3389/fgene.2022.1092678,https://pubmed.ncbi.nlm.nih.gov/36761693/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,29025010,"Sperm function, protein phosphorylation, and metabolism differ in mice lacking successive sperm-specific glycolytic enzymes.",2017,10.1093/biolre/iox103,https://pubmed.ncbi.nlm.nih.gov/29025010/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,31649539,Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico.,2019,10.3389/fphar.2019.01169,https://pubmed.ncbi.nlm.nih.gov/31649539/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,36777542,Integrated GWAS and transcriptomic analysis reveal the candidate salt-responding genes regulating Na+/K+ balance in barley (Hordeum vulgare L.).,2022,10.3389/fpls.2022.1004477,https://pubmed.ncbi.nlm.nih.gov/36777542/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,33658940,β-carotene Rescues Busulfan Disrupted Spermatogenesis Through Elevation in Testicular Antioxidant Capability.,2021,10.3389/fphar.2021.593953,https://pubmed.ncbi.nlm.nih.gov/33658940/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,35472738,Dietary quercetin and vitamin E supplementation modulates the reproductive performance and antioxidant capacity of aged male breeder chickens.,2022,10.1016/j.psj.2022.101851,https://pubmed.ncbi.nlm.nih.gov/35472738/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGK2,ENSG00000170950,CTA,26677959,Characteristics of testis-specific phosphoglycerate kinase 2 and its association with human sperm quality.,2016,10.1093/humrep/dev301,https://pubmed.ncbi.nlm.nih.gov/26677959/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKDREJ,ENSG00000130943,CTA,37760215,Transcriptome Studies Reveal the N6-Methyladenosine Differences in Testis of Yaks at Juvenile and Sexual Maturity Stages.,2023,10.3390/ani13182815,https://pubmed.ncbi.nlm.nih.gov/37760215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKDREJ,ENSG00000130943,CTA,35145544,Identification of Key Genes Related to Postnatal Testicular Development Based on Transcriptomic Data of Testis in Hu Sheep.,2021,10.3389/fgene.2021.773695,https://pubmed.ncbi.nlm.nih.gov/35145544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKDREJ,ENSG00000130943,CTA,25304980,Sexual selection and the adaptive evolution of PKDREJ protein in primates and rodents.,2015,10.1093/molehr/gau095,https://pubmed.ncbi.nlm.nih.gov/25304980/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKDREJ,ENSG00000130943,CTA,30109710,Genetic dissection of bull fertility in US Jersey dairy cattle.,2018,10.1111/age.12710,https://pubmed.ncbi.nlm.nih.gov/30109710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKDREJ,ENSG00000130943,CTA,28271061,Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes.,2017,10.3389/fcell.2017.00005,https://pubmed.ncbi.nlm.nih.gov/28271061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKDREJ,ENSG00000130943,CTA,16261614,Polycystic kidney disease and receptor for egg jelly is a plasma membrane protein of mouse sperm head.,2006,10.1002/mrd.20410,https://pubmed.ncbi.nlm.nih.gov/16261614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKDREJ,ENSG00000130943,CTA,18562295,A polycystin-1 controls postcopulatory reproductive selection in mice.,2008,10.1073/pnas.0800603105,https://pubmed.ncbi.nlm.nih.gov/18562295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKDREJ,ENSG00000130943,CTA,16883570,"Functional characterization of PKDREJ, a male germ cell-restricted polycystin.",2006,10.1002/jcp.20755,https://pubmed.ncbi.nlm.nih.gov/16883570/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKDREJ,ENSG00000130943,CTA,17564962,Evidence of amino acid diversity-enhancing selection within humans and among primates at the candidate sperm-receptor gene PKDREJ.,2007,10.1086/518695,https://pubmed.ncbi.nlm.nih.gov/17564962/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKDREJ,ENSG00000130943,CTA,26831942,Recent Selection Changes in Human Genes under Long-Term Balancing Selection.,2016,10.1093/molbev/msw023,https://pubmed.ncbi.nlm.nih.gov/26831942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKDREJ,ENSG00000130943,CTA,25525164,Exome array analysis identifies CAV1/CAV2 as a susceptibility locus for intraocular pressure.,2014,10.1167/iovs.14-15204,https://pubmed.ncbi.nlm.nih.gov/25525164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKDREJ,ENSG00000130943,CTA,9949214,Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein.,1999,10.1093/hmg/8.3.543,https://pubmed.ncbi.nlm.nih.gov/9949214/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKDREJ,ENSG00000130943,CTA,24756726,The TRPP subfamily and polycystin-1 proteins.,2014,10.1007/978-3-642-54215-2_27,https://pubmed.ncbi.nlm.nih.gov/24756726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKDREJ,ENSG00000130943,CTA,10602361,Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2).,1999,10.1038/sj.ejhg.5200383,https://pubmed.ncbi.nlm.nih.gov/10602361/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKDREJ,ENSG00000130943,CTA,15008854,"A third sea urchin sperm receptor for egg jelly module protein, suREJ2, concentrates in the plasma membrane over the sperm mitochondrion.",2004,10.1111/j.1440-169x.2004.00729.x,https://pubmed.ncbi.nlm.nih.gov/15008854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,42321253,"siRNA-mediated silencing of placenta-specific protein 1 (PLAC1) alters CD4+, CD8+, and regulatory T cells in a murine colon cancer model.",2026,10.1038/s41598-026-45740-6,https://pubmed.ncbi.nlm.nih.gov/42321253/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,42589696,Transcriptomic Analysis of &lt;i&gt;Plac1&lt;/i&gt; Ablation Reveals Broad Alterations in Signaling Pathways Essential for Prenatal Development and Overlap with a Preeclampsia-Associated Signature.,2026,10.3390/ijms27157046,https://pubmed.ncbi.nlm.nih.gov/42589696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,42007670,Fundamental and unique roles of PLAC1 in the regulation of rat and human trophoblast cell development.,2026,10.1242/dev.205290,https://pubmed.ncbi.nlm.nih.gov/42007670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,40902108,Placenta specific 1: a novel marker for detection of metastasis in mouse model of breast cancer.,2025,10.1080/1354750x.2025.2556166,https://pubmed.ncbi.nlm.nih.gov/40902108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,40607388,A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors.,2025,10.3389/fimmu.2025.1537876,https://pubmed.ncbi.nlm.nih.gov/40607388/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,40056047,Plac1&lt;sup&gt;+&lt;/sup&gt; Tumor Cell-Treg Interplay Supports Tumorigenesis and Progression of Head and Neck Cancer.,2025,10.1002/advs.202417312,https://pubmed.ncbi.nlm.nih.gov/40056047/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,41884401,Serum PLAC1 levels for differential diagnosis between cervical intraepithelial neoplasia and invasive cervical cancer: a prospective observational study.,2026,10.1007/s10616-026-00938-4,https://pubmed.ncbi.nlm.nih.gov/41884401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,42113594,The people behind the papers - Ayelen Moreno-Irusta and Michael J. Soares.,2026,10.1242/dev.205763,https://pubmed.ncbi.nlm.nih.gov/42113594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,37538244,Investigation of Expression Profile of Placenta-specific 1 (PLAC1) in Acute Myeloid and Lymphoid Leukemias.,2023,10.18502/ajmb.v15i3.12926,https://pubmed.ncbi.nlm.nih.gov/37538244/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,38378537,Changes in plasma PLAC-1 concentration and its expression during early-mid pregnancy in bovine placental tissues - a pilot study.,2024,10.1186/s12917-024-03898-z,https://pubmed.ncbi.nlm.nih.gov/38378537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,37568074,Differential expression of PLAC1 and Netrin-1 in liver metastasis of colorectal cancer and its predictive value.,2023,10.1186/s12876-023-02908-y,https://pubmed.ncbi.nlm.nih.gov/37568074/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,42278560,Serum sPD-L1 Levels in Early Pregnancy Predict Fetal Growth Restriction and Its Subtypes: A Prospective Nested Case-Control Study.,2026,10.3390/ijms27115037,https://pubmed.ncbi.nlm.nih.gov/42278560/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,39814247,Identification of PLAC1 as a prognostic biomarker and molecular target in clear cell renal cell carcinoma.,2025,10.1016/j.cellsig.2025.111606,https://pubmed.ncbi.nlm.nih.gov/39814247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,39549936,PLAC1 augments the malignant phenotype of cervical cancer through the mTOR/HIF-1α/Snail signaling pathway.,2024,10.1016/j.lfs.2024.123242,https://pubmed.ncbi.nlm.nih.gov/39549936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,39332465,Production and characterization of a panel of anti-mouse placenta-specific protein 1 (plac1) monoclonal antibodies.,2025,10.1016/j.ab.2024.115682,https://pubmed.ncbi.nlm.nih.gov/39332465/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,35814442,Plac1 Remodels the Tumor Immune Evasion Microenvironment and Predicts Therapeutic Response in Head and Neck Squamous Cell Carcinoma.,2022,10.3389/fonc.2022.919436,https://pubmed.ncbi.nlm.nih.gov/35814442/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,37057240,Identification of Cancer/Testis Antigens Related to Gastric Cancer Prognosis Based on Co-Expression Network and Integrated Transcriptome Analyses.,2023,10.4103/abr.abr_400_21,https://pubmed.ncbi.nlm.nih.gov/37057240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,35509359,Optimization of Expression and Purification of Recombinant Mouse plac1.,2022,10.18502/ajmb.v14i1.8171,https://pubmed.ncbi.nlm.nih.gov/35509359/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,34523695,"PLAC1 is an independent predictor of poor survival, and promotes cell proliferation and invasion in cervical cancer.",2021,10.3892/mmr.2021.12440,https://pubmed.ncbi.nlm.nih.gov/34523695/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,36835024,The Oncogenic Theory of Preeclampsia: Is Amniotic Mesenchymal Stem Cells-Derived PLAC1 Involved?,2023,10.3390/ijms24043612,https://pubmed.ncbi.nlm.nih.gov/36835024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,40335497,Author Correction: Placenta-specific1 (PLAC1) is a potential target for antibody-drug conjugate-based prostate cancer immunotherapy.,2025,10.1038/s41598-025-00193-1,https://pubmed.ncbi.nlm.nih.gov/40335497/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,36084365,Immunization with placenta-specific 1 (plac1) induces potent anti-tumor responses and prolongs survival in a mouse model of melanoma.,2022,10.1016/j.advms.2022.08.002,https://pubmed.ncbi.nlm.nih.gov/36084365/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,33457076,Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma.,2020,10.1080/2162402x.2020.1856545,https://pubmed.ncbi.nlm.nih.gov/33457076/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,31952435,In silico Evaluation of PLAC1-fliC As a Chimeric Vaccine against Breast Cancer,2020,,https://pubmed.ncbi.nlm.nih.gov/31952435/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,39484215,COADREADx: A comprehensive algorithmic dissection of colorectal cancer unravels salient biomarkers and actionable insights into its discrete progression.,2024,10.7717/peerj.18347,https://pubmed.ncbi.nlm.nih.gov/39484215/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,33106058,Discovery of a potential biomarker for immunotherapy of melanoma: PLAC1 as an emerging target.,2020,10.1080/08923973.2020.1837865,https://pubmed.ncbi.nlm.nih.gov/33106058/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,32701605,Placenta-specific protein 1 enhances liver metastatic potential and is associated with the PI3K/AKT/NF-κB signaling pathway in colorectal cancer.,2021,10.1097/cej.0000000000000611,https://pubmed.ncbi.nlm.nih.gov/32701605/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,31165204,PLAC1: biology and potential application in cancer immunotherapy.,2019,10.1007/s00262-019-02350-8,https://pubmed.ncbi.nlm.nih.gov/31165204/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,32153735,Expression of Human Placenta-specific 1 (PLAC1) in CHO-K1 Cells.,2020,,https://pubmed.ncbi.nlm.nih.gov/32153735/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,34577642,The Synthetic Curcumin Analog HO-3867 Rescues Suppression of PLAC1 Expression in Ovarian Cancer Cells.,2021,10.3390/ph14090942,https://pubmed.ncbi.nlm.nih.gov/34577642/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,39362807,Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque.,2025,10.1016/j.placenta.2024.09.013,https://pubmed.ncbi.nlm.nih.gov/39362807/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,39499161,"Placental gene therapy in nonhuman primates: a pilot study of maternal, placental, and fetal response to non-viral, polymeric nanoparticle delivery of IGF1.",2024,10.1093/molehr/gaae038,https://pubmed.ncbi.nlm.nih.gov/39499161/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,15803460,PLAC1 expression increases during trophoblast differentiation: evidence for regulatory interactions with the fibroblast growth factor-7 (FGF-7) axis.,2005,10.1002/mrd.20272,https://pubmed.ncbi.nlm.nih.gov/15803460/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,15608456,Rapid clearance of mRNA for PLAC1 gene in maternal blood after delivery.,2005,10.1159/000081365,https://pubmed.ncbi.nlm.nih.gov/15608456/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,12412044,"PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor.",2002,10.1002/mrd.10200,https://pubmed.ncbi.nlm.nih.gov/12412044/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC1,ENSG00000170965,CTA,10995572,"PLAC1, an Xq26 gene with placenta-specific expression.",2000,10.1006/geno.2000.6302,https://pubmed.ncbi.nlm.nih.gov/10995572/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,42298771,Clinical Features and PLCZ1 Gene Variants in Two Cases of Male Infertility: A Case Series and Literature Review.,2026,10.1002/mgg3.70250,https://pubmed.ncbi.nlm.nih.gov/42298771/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,40106576,Genomic Insights into Fertilization: Tracing PLCZ1 Orthologs Across Amphibian Lineages.,2025,10.1093/gbe/evaf052,https://pubmed.ncbi.nlm.nih.gov/40106576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,40794537,PLCZ1 gene mutation leads to fertilization disorder: a case report.,2025,10.5935/1518-0557.20250028,https://pubmed.ncbi.nlm.nih.gov/40794537/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,41618099,Characterization and therapy of fertilization failure in murine and human models with HNRNPR mutations.,2026,10.1038/s44321-026-00374-z,https://pubmed.ncbi.nlm.nih.gov/41618099/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,42789056,A novel homozygous chromosomal deletion encompassing the ACTL9 gene is associated with cIVF polyspermy and male infertility.,2026,10.4103/aja202630,https://pubmed.ncbi.nlm.nih.gov/42789056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,41498800,Uterine cellular leiomyoma with a novel HMGA2::PLCZ1 fusion and aberrant cyclin D1 expression: expanding the molecular spectrum and highlighting a diagnostic pitfall.,2026,10.1007/s00428-025-04387-w,https://pubmed.ncbi.nlm.nih.gov/41498800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,42330090,Pathogenic variants in ACTRT3 lead to male infertility characterized by fertilization defects.,2026,10.1093/humrep/deag097,https://pubmed.ncbi.nlm.nih.gov/42330090/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,41559360,Correction to: Uterine cellular leiomyoma with a novel HMGA2::PLCZ1 fusion and aberrant cyclin D1 expression: expanding the molecular spectrum and highlighting a diagnostic pitfall.,2026,10.1007/s00428-026-04418-0,https://pubmed.ncbi.nlm.nih.gov/41559360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,39042720,Novel PLCZ1 compound heterozygous mutations indicate gene dosage effect involved in total fertilisation failure after ICSI.,2024,10.1530/rep-23-0466,https://pubmed.ncbi.nlm.nih.gov/39042720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,41412351,Total flavonoids of Epimedium ameliorate testicular damage via keap1-Nrf2/ARE signalling and multi-target regulation.,2026,10.1016/j.reprotox.2025.109142,https://pubmed.ncbi.nlm.nih.gov/41412351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,38133249,Phospholipase C Zeta 1 (PLCZ1): The Function and Potential for Fertility Assessment and In Vitro Embryo Production in Cattle and Horses.,2023,10.3390/vetsci10120698,https://pubmed.ncbi.nlm.nih.gov/38133249/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,41818057,Pathogenic homozygous PLCZ1 mutation reduces sperm protein levels with a simulated reduction of PIP2 binding: a case report.,2026,10.1530/raf-25-0085,https://pubmed.ncbi.nlm.nih.gov/41818057/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,38445955,Novel PLCZ1 mutation caused polyspermy during in vitro fertilization.,2024,10.4103/aja202376,https://pubmed.ncbi.nlm.nih.gov/38445955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,36613757,Plcz1 Deficiency Decreased Fertility in Male Mice Which Is Associated with Sperm Quality Decline and Abnormal Cytoskeleton in Epididymis.,2022,10.3390/ijms24010314,https://pubmed.ncbi.nlm.nih.gov/36613757/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,38027210,RNA sequencing profiles reveals progressively reduced spermatogenesis with progression in adult cryptorchidism.,2023,10.3389/fendo.2023.1271724,https://pubmed.ncbi.nlm.nih.gov/38027210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,42487003,Reduced and Mislocalized ACTL7A in Globozoospermia: Implications for Sperm Chromatin Integrity and Infertility.,2026,10.1007/s43032-026-02159-8,https://pubmed.ncbi.nlm.nih.gov/42487003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,39411542,High rate of detected variants in male &lt;i&gt;PLCZ1&lt;/i&gt; and &lt;i&gt;ACTL7A&lt;/i&gt; genes causing failed fertilization after ICSI.,2024,10.1093/hropen/hoae057,https://pubmed.ncbi.nlm.nih.gov/39411542/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,38048167,Defects in phospholipase C zeta cause polyspermy and low fertilization after conventional IVF: not just ICSI failure.,2024,10.4103/aja202355,https://pubmed.ncbi.nlm.nih.gov/38048167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,41594564,"The &lt;i&gt;Xenopus&lt;/i&gt; Oocyte System: Molecular Dynamics of Maturation, Fertilization, and Post-Ovulatory Fate.",2025,10.3390/biom16010022,https://pubmed.ncbi.nlm.nih.gov/41594564/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,40838122,"Fertilization in the African clawed frog &lt;i&gt;, Xenopus laevis&lt;/i&gt; , requires an egg-derived PLC to signal the fast block to polyspermy.",2025,10.17912/micropub.biology.001638,https://pubmed.ncbi.nlm.nih.gov/40838122/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,35312629,SPERM FACTORS AND EGG ACTIVATION: Phospholipase C zeta (PLCZ1) and the clinical diagnosis of oocyte activation deficiency.,2022,10.1530/rep-21-0458,https://pubmed.ncbi.nlm.nih.gov/35312629/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,40649994,Sperm-Derived Dysfunction of Human Embryos: Molecular Mechanisms and Clinical Resolution.,2025,10.3390/ijms26136217,https://pubmed.ncbi.nlm.nih.gov/40649994/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,40572651,"Phospholipase Cζ, the Molecular Spark of Fertilization and Male Infertility: Insights from Bench to Bedside.",2025,10.3390/medicina61060963,https://pubmed.ncbi.nlm.nih.gov/40572651/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,32840018,Novel mutations in the PLCZ1 gene associated with human low or failed fertilization.,2020,10.1002/mgg3.1470,https://pubmed.ncbi.nlm.nih.gov/32840018/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,36931261,Assisted oocyte activation does not overcome recurrent embryo developmental problems.,2023,10.1093/humrep/dead051,https://pubmed.ncbi.nlm.nih.gov/36931261/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,36977357,"Total fertilization failure after ICSI: insights into pathophysiology, diagnosis, and management through artificial oocyte activation.",2023,10.1093/humupd/dmad007,https://pubmed.ncbi.nlm.nih.gov/36977357/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,36379263,Profiling the male germline genome to unravel its reproductive potential.,2023,10.1016/j.fertnstert.2022.11.006,https://pubmed.ncbi.nlm.nih.gov/36379263/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,28694258,PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence.,2017,10.1242/dev.150227,https://pubmed.ncbi.nlm.nih.gov/28694258/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,34638758,Epigenetic Biomarkers of Transition from Metabolically Healthy Obesity to Metabolically Unhealthy Obesity Phenotype: A Prospective Study.,2021,10.3390/ijms221910417,https://pubmed.ncbi.nlm.nih.gov/34638758/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,33877510,Single-center thorough evaluation and targeted treatment of globozoospermic men.,2021,10.1007/s10815-021-02191-4,https://pubmed.ncbi.nlm.nih.gov/33877510/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,26721930,Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP.,2016,10.1093/hmg/ddv617,https://pubmed.ncbi.nlm.nih.gov/26721930/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLCZ1,ENSG00000139151,CTA,14697805,Rescue of defective pancreatic secretion in cystic-fibrosis cells by suppression of a novel isoform of phospholipase C.,2003,10.1016/s0140-6736(03)15100-8,https://pubmed.ncbi.nlm.nih.gov/14697805/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
PLCZ1,ENSG00000139151,CTA,12416999,"Sperm phospholipase Czeta from humans and cynomolgus monkeys triggers Ca2+ oscillations, activation and development of mouse oocytes.",2002,10.1530/rep.0.1240611,https://pubmed.ncbi.nlm.nih.gov/12416999/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POM121L12,ENSG00000221900,CTA,38291185,A genome-wide association study reveals the relationship between human genetic variation and the nasal microbiome.,2024,10.1038/s42003-024-05822-5,https://pubmed.ncbi.nlm.nih.gov/38291185/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POM121L12,ENSG00000221900,CTA,39424413,Genome-Wide Search for Nonadditive Allele Effects Identifies &lt;i&gt;PSKH2&lt;/i&gt; as Involved in the Variability of Factor V Activity.,2024,10.1161/jaha.124.034943,https://pubmed.ncbi.nlm.nih.gov/39424413/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POM121L12,ENSG00000221900,CTA,35884534,"Genomic Landscape, Clinical Features and Outcomes of Non-Small Cell Lung Cancer Patients Harboring BRAF Alterations of Distinct Functional Classes.",2022,10.3390/cancers14143472,https://pubmed.ncbi.nlm.nih.gov/35884534/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEM,ENSG00000222036,CTA,40044876,The LncRNA lnc-POTEM-4:14 promotes HCC progression by interacting with FOXK1.,2025,10.1038/s41598-025-92614-4,https://pubmed.ncbi.nlm.nih.gov/40044876/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEM,ENSG00000222036,CTA,39278454,Long non-coding RNA LNC-POTEM-4 promotes HCC progression via the LNC-POTEM-4/miR-149-5p/Wnt4 signaling axis.,2024,10.1016/j.cellsig.2024.111412,https://pubmed.ncbi.nlm.nih.gov/39278454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEM,ENSG00000222036,CTA,39714566,Expanding Polycyclic Tetramate Macrolactam (PoTeM) Core Structure Diversity by Chemo-Enzymatic Synthesis and Bioengineering.,2025,10.1002/anie.202420335,https://pubmed.ncbi.nlm.nih.gov/39714566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEM,ENSG00000222036,CTA,39794810,A plug-and-play system for polycyclic tetramate macrolactam production and functionalization.,2025,10.1186/s12934-024-02630-8,https://pubmed.ncbi.nlm.nih.gov/39794810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEM,ENSG00000222036,CTA,41628295,Discovery and Biosynthesis of Antifungal Alteramide C from the Biocontrol Agent &lt;i&gt;Lysobacter&lt;/i&gt; sp. SR01.,2026,10.1021/acs.jafc.5c08315,https://pubmed.ncbi.nlm.nih.gov/41628295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEM,ENSG00000222036,CTA,37280521,Development and nationwide validation of kidney graft injury markers using urinary exosomes and microvesicles (complete English translation of the Japanese version).,2023,10.1186/s12882-023-03189-z,https://pubmed.ncbi.nlm.nih.gov/37280521/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEM,ENSG00000222036,CTA,35364800,The expression discrepancy and characteristics of long non-coding RNAs in peripheral blood leukocytes from amyotrophic lateral sclerosis patients.,2022,10.1007/s12035-022-02789-4,https://pubmed.ncbi.nlm.nih.gov/35364800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEM,ENSG00000222036,CTA,33083497,Integrative Analyses of Genes Associated with Fulminant Type 1 Diabetes.,2020,10.1155/2020/1025857,https://pubmed.ncbi.nlm.nih.gov/33083497/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEM,ENSG00000222036,CTA,33712422,"An Antifungal Polycyclic Tetramate Macrolactam, Heat-Stable Antifungal Factor (HSAF), Is a Novel Oxidative Stress Modulator in Lysobacter enzymogenes.",2021,10.1128/aem.03105-20,https://pubmed.ncbi.nlm.nih.gov/33712422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEM,ENSG00000222036,CTA,31303988,Construction of a hybrid gene cluster to reveal coupled ring formation-hydroxylation in the biosynthesis of HSAF and analogues from Lysobacter enzymogenes.,2019,10.1039/c9md00154a,https://pubmed.ncbi.nlm.nih.gov/31303988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEM,ENSG00000222036,CTA,29573092,Biosynthesis of the Polycyclic System in the Antifungal HSAF and Analogues from Lysobacter enzymogenes.,2018,10.1002/anie.201802488,https://pubmed.ncbi.nlm.nih.gov/29573092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEM,ENSG00000222036,CTA,28587571,"Expression Profiling of lncRNAs, miRNAs, and mRNAs and Their Differential Expression in Leiomyoma Using Next-Generation RNA Sequencing.",2018,10.1177/1933719117711265,https://pubmed.ncbi.nlm.nih.gov/28587571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEM,ENSG00000222036,CTA,38281534,The natural polycyclic tetramate macrolactam HSAF inhibit Fusarium graminearum through altering cell membrane integrity by targeting FgORP1.,2024,10.1016/j.ijbiomac.2024.129744,https://pubmed.ncbi.nlm.nih.gov/38281534/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP1R2B,ENSG00000231989,CTA,23506001,Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa.,2013,10.1186/1471-2121-14-15,https://pubmed.ncbi.nlm.nih.gov/23506001/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP1R2B,ENSG00000231989,CTA,24195737,Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes.,2013,10.1186/1471-2148-13-242,https://pubmed.ncbi.nlm.nih.gov/24195737/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42899254,PRAME Augments K63-Linked Ubiquitination and Stabilization of METTL3 to Promote Lung Adenocarcinoma Metastasis.,2026,10.1002/mco2.71066,https://pubmed.ncbi.nlm.nih.gov/42899254/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42660821,PRAME promotes invasion and metastasis of salivary adenoid cystic carcinoma by regulating RARα stability via the cullin2 ubiquitin-proteasome system.,2026,10.1002/ctm2.70787,https://pubmed.ncbi.nlm.nih.gov/42660821/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42738395,Performance of PRAME Immunohistochemistry in Distinguishing Classic Hodgkin Lymphoma from Anaplastic Large Cell Lymphoma and T-Cell Lymphoma.,2026,10.3390/cancers18172875,https://pubmed.ncbi.nlm.nih.gov/42738395/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42104475,Prognostic value of PRAME gene promoter methylation and expression in hepatocellular carcinoma.,2026,10.1186/s13148-026-02152-7,https://pubmed.ncbi.nlm.nih.gov/42104475/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42674817,Integrated Immunotherapy Target Atlas for Ewing Sarcoma.,2026,10.21873/cgp.20605,https://pubmed.ncbi.nlm.nih.gov/42674817/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,41968569,"Immunohistochemical Analysis of Potential Therapeutic Targets PRAME, FOLR1, and CLDN18.2 in Salivary Gland Carcinomas.",2026,10.1002/cam4.71799,https://pubmed.ncbi.nlm.nih.gov/41968569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,41892080,PRAME Expression in Melanoacanthomas: Expanding the Spectrum of Positive Melanocytes in Sun-Exposed Skin.,2026,10.3390/dermatopathology13010014,https://pubmed.ncbi.nlm.nih.gov/41892080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,41644270,Shared PRAME epitopes are T-cell targets in NUT carcinoma.,2026,10.1136/jitc-2025-013539,https://pubmed.ncbi.nlm.nih.gov/41644270/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42882837,H3K27M Mutation Modulates the Antigenic Landscape in Diffuse Midline Glioma.,2026,10.3390/cancers18193142,https://pubmed.ncbi.nlm.nih.gov/42882837/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42458521,PRAME immunohistochemistry demonstrates high diagnostic accuracy for distinguishing melanoma from nevi but no observed association with pT stage in cutaneous melanoma: a Vietnamese clinicopathological study.,2026,10.1186/s13000-026-01806-7,https://pubmed.ncbi.nlm.nih.gov/42458521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42170260,DNA hypomethylation-activated PRAME drives early-stage lung adenocarcinoma recurrence via ZNF740 and PI3K/AKT/mTOR signaling.,2026,10.21037/tlcr-2025-1-1417,https://pubmed.ncbi.nlm.nih.gov/42170260/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,41844897,Emergence of the cancer antigen PRAME as key player in epigenetic dysregulation and renal tumorigenesis.,2026,10.1038/s41418-026-01700-1,https://pubmed.ncbi.nlm.nih.gov/41844897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42517272,"The evolution of cellular therapies in sarcoma: Breakthroughs, challenges, and future directions.",2026,10.1080/21645515.2026.2708435,https://pubmed.ncbi.nlm.nih.gov/42517272/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,41985065,A Novel Nanobody-Based TCR-like CAR T Therapy Targeting PRAME for the Treatment of Acute Myeloid Leukemia.,2026,10.1158/1078-0432.ccr-25-2726,https://pubmed.ncbi.nlm.nih.gov/41985065/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42647382,Quantifying the Interplay Between PRAME Expression and Classical Morphology: A Multivariable Analysis of 954 Suspected Melanocytic Lesions.,2026,10.3390/dermatopathology13030035,https://pubmed.ncbi.nlm.nih.gov/42647382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42200754,Diagnostic and Prognostic Values of PRAME Immunohistochemistry in Acral Lentiginous Melanoma.,2026,10.1097/dad.0000000000003305,https://pubmed.ncbi.nlm.nih.gov/42200754/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42746728,PRAME as a Diagnostic Adjunct in Clear Cell Sarcoma.,2026,10.1097/pai.0000000000001360,https://pubmed.ncbi.nlm.nih.gov/42746728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42438600,Identification of immunopeptides (pHLA) as candidate therapeutic targets in chondrosarcoma.,2026,10.1016/j.jbo.2026.100780,https://pubmed.ncbi.nlm.nih.gov/42438600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,40994043,Development of a PRAME pMHC targeted T cell engager for solid tumor therapy.,2025,10.1080/19420862.2025.2563773,https://pubmed.ncbi.nlm.nih.gov/40994043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,40961095,"PRAME-AS lncRNA, regulated by MZF1, modulates PRAME expression and cell stemness.",2025,10.1371/journal.pone.0331190,https://pubmed.ncbi.nlm.nih.gov/40961095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42734903,Top advances of the year in autologous cellular therapy in melanoma and solid tumors.,2026,10.1002/cncr.70612,https://pubmed.ncbi.nlm.nih.gov/42734903/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,40868240,Therapeutic Opportunities in Melanoma Through PRAME Expression.,2025,10.3390/biomedicines13081988,https://pubmed.ncbi.nlm.nih.gov/40868240/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42874444,"Emerging immunotherapies in melanoma beyond immune checkpoint inhibitors: Vaccines, intralesional therapies, adoptive cell therapies, and T-cell engagers.",2026,10.1016/j.ctarc.2026.101482,https://pubmed.ncbi.nlm.nih.gov/42874444/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42380677,Multi-antigen-targeting T cells in pediatric central nervous system tumors: a phase 1 trial.,2026,10.1038/s41591-026-04449-9,https://pubmed.ncbi.nlm.nih.gov/42380677/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,41964902,Landscape of T-cell engagers in solid tumors.,2026,10.1093/oncolo/oyag129,https://pubmed.ncbi.nlm.nih.gov/41964902/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42518808,Advances in the multimodal management of central nervous system solitary fibrous tumors.,2026,10.3389/fonc.2026.1778689,https://pubmed.ncbi.nlm.nih.gov/42518808/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42509244,The Dendritic Cell-based Vaccine PROTEXI leverages Antiviral CD4 T cell Memory to boost anti-tumor immune responses in mice.,2026,10.1038/s41467-026-74891-3,https://pubmed.ncbi.nlm.nih.gov/42509244/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,41008812,"First-in-Human Study of MDG1011, a TCR-T Therapy Directed Against HLA-A*02:01-Restricted PRAME Antigen for High-Risk Myeloid and Lymphoid Neoplasms.",2025,10.3390/cancers17182968,https://pubmed.ncbi.nlm.nih.gov/41008812/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42779343,Search for leukemia-restricted targets: a new paradigm for precision immunotherapy in acute myeloid leukemia.,2026,10.3324/haematol.2026.301517,https://pubmed.ncbi.nlm.nih.gov/42779343/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,40634759,"The AML immune paradox: decoding escape pathways and pioneering checkpoint, vaccine, and combination strategies.",2025,10.1007/s10238-025-01795-9,https://pubmed.ncbi.nlm.nih.gov/40634759/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,40581703,"Unleashing the future of cancer immunotherapy: in silico design of a multi-epitope and mRNA vaccine duo targeting EWSR1-ATF1, EWSR1-CREB1, and PRAME to conquer clear cell sarcoma using immunoinformatics approaches.",2025,10.1007/s12032-025-02863-6,https://pubmed.ncbi.nlm.nih.gov/40581703/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,42259311,PRAME Expression in HPV-associated and Differentiated Vulvar Intraepithelial Neoplasia-associated Vulvar Squamous Neoplasia.,2026,10.1097/pgp.0000000000001196,https://pubmed.ncbi.nlm.nih.gov/42259311/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAME,ENSG00000185686,CTA,9047241,Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor.,1997,10.1016/s1074-7613(00)80426-4,https://pubmed.ncbi.nlm.nih.gov/9047241/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM7,ENSG00000126856,CTA,40979936,Identification of Specific LncRNA Markers in Severe Tuberculosis for Early Diagnosis.,2025,10.2147/idr.s540446,https://pubmed.ncbi.nlm.nih.gov/40979936/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM7,ENSG00000126856,CTA,33719332,Pinpointing the PRDM9-PRDM7 Gene Duplication Event During Primate Divergence.,2021,10.3389/fgene.2021.593725,https://pubmed.ncbi.nlm.nih.gov/33719332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM7,ENSG00000126856,CTA,32000999,Investigation of PRDM7 and PRDM12 expression pattern during mouse embryonic development by using a modified passive clearing technique.,2020,10.1016/j.bbrc.2019.12.133,https://pubmed.ncbi.nlm.nih.gov/32000999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM7,ENSG00000126856,CTA,34341332,Genome-wide DNA methylation and gene expression analyses in monozygotic twins identify potential biomarkers of depression.,2021,10.1038/s41398-021-01536-y,https://pubmed.ncbi.nlm.nih.gov/34341332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM7,ENSG00000126856,CTA,27129774,PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase.,2016,10.1074/jbc.m116.721472,https://pubmed.ncbi.nlm.nih.gov/27129774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM7,ENSG00000126856,CTA,35603952,N-type calcium channel v2.2 is a target of TCF21 in adrenocortical carcinomas.,2022,10.4149/neo_2022_220106n25,https://pubmed.ncbi.nlm.nih.gov/35603952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM7,ENSG00000126856,CTA,30071651,PRDM Histone Methyltransferase mRNA Levels Increase in Response to Curative Hormone Treatment for Cryptorchidism-Dependent Male Infertility.,2018,10.3390/genes9080391,https://pubmed.ncbi.nlm.nih.gov/30071651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM7,ENSG00000126856,CTA,29702639,"A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte gene expression, sperm production and fertility.",2018,10.1371/journal.pgen.1007295,https://pubmed.ncbi.nlm.nih.gov/29702639/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM7,ENSG00000126856,CTA,17916234,Family expansion and gene rearrangements contributed to the functional specialization of PRDM genes in vertebrates.,2007,10.1186/1471-2148-7-187,https://pubmed.ncbi.nlm.nih.gov/17916234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM7,ENSG00000126856,CTA,27203728,Zinc Finger Domain of the PRDM9 Gene on Chromosome 1 Exhibits High Diversity in Ruminants but Its Paralog PRDM7 Contains Multiple Disruptive Mutations.,2016,10.1371/journal.pone.0156159,https://pubmed.ncbi.nlm.nih.gov/27203728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM7,ENSG00000126856,CTA,25935441,"Genomic profile of a Li-Fraumeni-like syndrome patient with a 45,X/46,XX karyotype, presenting neither mutations in TP53 nor clinical stigmata of Turner syndrome.",2015,10.1016/j.cancergen.2015.03.004,https://pubmed.ncbi.nlm.nih.gov/25935441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM7,ENSG00000126856,CTA,12761041,Gene expression differences in quiescent versus regenerating hair cells of avian sensory epithelia: implications for human hearing and balance disorders.,2003,10.1093/hmg/ddg150,https://pubmed.ncbi.nlm.nih.gov/12761041/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM7,ENSG00000126856,CTA,6318753,Molecular cloning and expression in streptomyces lividans of a hygromycin B phosphotransferase gene from Streptomyces hygroscopicus.,1983,10.1016/0006-291x(83)91533-4,https://pubmed.ncbi.nlm.nih.gov/6318753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,42243539,NR3C1/PRKACG-mediated impairment of mitochondrial quality control underlies stress-induced hypothalamic neuronal injury.,2026,10.1038/s42003-026-10284-y,https://pubmed.ncbi.nlm.nih.gov/42243539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,41941847,"Molecular mechanisms of DBDPE-induced spermatogenic disorder: A network toxicology, machine learning, and in vivo experimental validation.",2026,10.1016/j.envint.2026.110220,https://pubmed.ncbi.nlm.nih.gov/41941847/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,40910032,The ceRNA Regulatory Network in Vitiligo: Evidence from Bioinformatics Analysis.,2025,10.2147/ccid.s528604,https://pubmed.ncbi.nlm.nih.gov/40910032/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,39634422,Identification of PANoptosis-based signature for predicting the prognosis and immunotherapy response in AML.,2024,10.1016/j.heliyon.2024.e40267,https://pubmed.ncbi.nlm.nih.gov/39634422/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,36923118,Exploring the common pathogenesis of Alzheimer's disease and type 2 diabetes mellitus via microarray data analysis.,2023,10.3389/fnagi.2023.1071391,https://pubmed.ncbi.nlm.nih.gov/36923118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,37623250,Differential Expression of Subsets of Genes Related to HDL Metabolism and Atherogenesis in the Peripheral Blood in Coronary Artery Disease.,2023,10.3390/cimb45080431,https://pubmed.ncbi.nlm.nih.gov/37623250/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,36183055,Breast cancer prediction with transcriptome profiling using feature selection and machine learning methods.,2022,10.1186/s12859-022-04965-8,https://pubmed.ncbi.nlm.nih.gov/36183055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,33991172,"PP1, PKA and DARPP-32 in breast cancer: A retrospective assessment of protein and mRNA expression.",2021,10.1111/jcmm.16447,https://pubmed.ncbi.nlm.nih.gov/33991172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,25061177,A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene.,2014,10.1182/blood-2014-01-551820,https://pubmed.ncbi.nlm.nih.gov/25061177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,33269026,HDL cholesterol is associated with PBMC expression of genes involved in HDL metabolism and atherogenesis.,2020,10.2478/jomb-2019-0052,https://pubmed.ncbi.nlm.nih.gov/33269026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,33222560,Use of bioinformatic analyses in identifying characteristic genes and mechanisms active in the progression of idiopathic thrombocytopenic purpura in individuals with different phenotypes.,2020,10.1177/0300060520971437,https://pubmed.ncbi.nlm.nih.gov/33222560/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,30289875,Identification of Key Genes and Pathways Associated with RUNX1 Mutations in Acute Myeloid Leukemia Using Bioinformatics Analysis.,2018,10.12659/msm.910916,https://pubmed.ncbi.nlm.nih.gov/30289875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,35505292,Associations of keratinocyte cancers with snp variants in the sonic hedgehog pathway.,2022,10.1186/s12885-022-09565-6,https://pubmed.ncbi.nlm.nih.gov/35505292/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,30819905,Complications of whole-exome sequencing for causal gene discovery in primary platelet secretion defects.,2019,10.3324/haematol.2018.204990,https://pubmed.ncbi.nlm.nih.gov/30819905/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,23593352,Evolutionary paths of the cAMP-dependent protein kinase (PKA) catalytic subunits.,2013,10.1371/journal.pone.0060935,https://pubmed.ncbi.nlm.nih.gov/23593352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,25396269,"A closer look at evolution: Variants (SNPs) of genes involved in skin pigmentation, including EXOC2, TYR, TYRP1, and DCT, are associated with 25(OH)D serum concentration.",2015,10.1210/en.2014-1238,https://pubmed.ncbi.nlm.nih.gov/25396269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,24055526,"Novel candidate genes for 46,XY gonadal dysgenesis identified by a customized 1 M array-CGH platform.",2013,10.1016/j.ejmg.2013.09.003,https://pubmed.ncbi.nlm.nih.gov/24055526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,24369246,[Application of genome-wide genechip for screening and identifying genes related to CD133(+)CD200(+) colorectal cancer stem cells].,2013,,https://pubmed.ncbi.nlm.nih.gov/24369246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKACG,ENSG00000165059,CTA,1339328,Localization of the catalytic subunit C gamma of the cAMP-dependent protein kinase gene (PRKACG) to human chromosome region 9q13.,1992,10.1159/000133286,https://pubmed.ncbi.nlm.nih.gov/1339328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPS1L1,ENSG00000229937,CTA,37248548,Structural basis of human PRPS2 filaments.,2023,10.1186/s13578-023-01037-z,https://pubmed.ncbi.nlm.nih.gov/37248548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPS1L1,ENSG00000229937,CTA,30113107,"Prps1l1, a testis-specific gene, is dispensable for mouse spermatogenesis.",2018,10.1002/mrd.23053,https://pubmed.ncbi.nlm.nih.gov/30113107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPS1L1,ENSG00000229937,CTA,28852147,Proteomics analysis to reveal biological pathways and predictive proteins in the survival of high-grade serous ovarian cancer.,2017,10.1038/s41598-017-10559-9,https://pubmed.ncbi.nlm.nih.gov/28852147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPS1L1,ENSG00000229937,CTA,21734401,Novel autosomal recessive nonsyndromic hearing impairment locus DFNB90 maps to 7p22.1-p15.3.,2011,10.1159/000320154,https://pubmed.ncbi.nlm.nih.gov/21734401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPS1L1,ENSG00000229937,CTA,2168892,A human testis-specific mRNA for phosphoribosylpyrophosphate synthetase that initiates from a non-AUG codon.,1990,10.1016/s0021-9258(17)46249-1,https://pubmed.ncbi.nlm.nih.gov/2168892/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPS1L1,ENSG00000229937,CTA,2166582,Selective activation of testis-specific genes in cultured rat spermatogenic cells.,1990,10.1016/0167-4781(90)90106-c,https://pubmed.ncbi.nlm.nih.gov/2166582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPS1L1,ENSG00000229937,CTA,16109937,Identification of residues responsible for the defective virulence gene regulator Mga produced by a natural mutant of Streptococcus pyogenes.,2005,10.1128/jb.187.17.5955-5966.2005,https://pubmed.ncbi.nlm.nih.gov/16109937/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR30,ENSG00000186143,CTA,38667850,"pRR30, pRR3.25% and Asymmetrical Entropy Descriptors in Atrial Fibrillation Detection.",2024,10.3390/e26040296,https://pubmed.ncbi.nlm.nih.gov/38667850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR30,ENSG00000186143,CTA,37549510,Integrated molecular-network analysis reveals infertility-associated key genes and transcription factors in the non-obstructive azoospermia.,2023,10.1016/j.ejogrb.2023.07.023,https://pubmed.ncbi.nlm.nih.gov/37549510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR30,ENSG00000186143,CTA,25562418,High-resolution 400K oligonucleotide array comparative genomic hybridization analysis of neurofibromatosis type 1-associated cutaneous neurofibromas.,2015,10.1016/j.gene.2014.12.064,https://pubmed.ncbi.nlm.nih.gov/25562418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS37,ENSG00000165076,CTA,37452050,Molecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model.,2023,10.1038/s41598-023-37700-1,https://pubmed.ncbi.nlm.nih.gov/37452050/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS37,ENSG00000165076,CTA,38731262,Single-Cell Transcriptome Sequencing Reveals Molecular Expression Differences and Marker Genes in Testes during the Sexual Maturation of Mongolian Horses.,2024,10.3390/ani14091258,https://pubmed.ncbi.nlm.nih.gov/38731262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS37,ENSG00000165076,CTA,38726127,Identification of necroptosis-related diagnostic biomarkers in coronary heart disease.,2024,10.1016/j.heliyon.2024.e30269,https://pubmed.ncbi.nlm.nih.gov/38726127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS37,ENSG00000165076,CTA,37118964,Differential Proteomic Analysis of Human Sperm: A Systematic Review to Identify Candidate Targets to Monitor Sperm Quality.,2024,10.5534/wjmh.220262,https://pubmed.ncbi.nlm.nih.gov/37118964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS37,ENSG00000165076,CTA,35471551,PRSS37 deficiency leads to impaired energy metabolism in testis and sperm revealed by DIA-based quantitative proteomic analysis.,2023,10.1007/s43032-022-00918-x,https://pubmed.ncbi.nlm.nih.gov/35471551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS37,ENSG00000165076,CTA,27649891,Low levels of PRSS37 protein in sperm are associated with many cases of unexplained male infertility.,2016,10.1093/abbs/gmw096,https://pubmed.ncbi.nlm.nih.gov/27649891/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS37,ENSG00000165076,CTA,30032357,Serine protease PRSS55 is crucial for male mouse fertility via affecting sperm migration and sperm-egg binding.,2018,10.1007/s00018-018-2878-9,https://pubmed.ncbi.nlm.nih.gov/30032357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS37,ENSG00000165076,CTA,23553430,Prss37 is required for male fertility in the mouse.,2013,10.1095/biolreprod.112.107086,https://pubmed.ncbi.nlm.nih.gov/23553430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS37,ENSG00000165076,CTA,30820981,Comparative proteomic analysis of high- and low-fertile buffalo bull spermatozoa for identification of fertility-associated proteins.,2019,10.1111/rda.13426,https://pubmed.ncbi.nlm.nih.gov/30820981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS37,ENSG00000165076,CTA,34729646,Proteomics study reveals the molecular mechanisms underlying cryotolerance induced by mild sublethal stress in human sperm.,2022,10.1007/s00441-021-03537-1,https://pubmed.ncbi.nlm.nih.gov/34729646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS37,ENSG00000165076,CTA,25921412,"Establishment, characterization, and application of pAcr-SP-NTP-EGFP transgenic mice in visualizing the oviduct-migrating ability of sperm from Prss37-null mice.",2015,10.1093/abbs/gmv031,https://pubmed.ncbi.nlm.nih.gov/25921412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS37,ENSG00000165076,CTA,34256996,Membrane lipid replacement with nano-micelles in human sperm cryopreservation improves post-thaw function and acrosome protein integrity.,2021,10.1016/j.rbmo.2021.05.005,https://pubmed.ncbi.nlm.nih.gov/34256996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS37,ENSG00000165076,CTA,24146633,Eleven candidate susceptibility genes for common familial colorectal cancer.,2013,10.1371/journal.pgen.1003876,https://pubmed.ncbi.nlm.nih.gov/24146633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS54,ENSG00000103023,CTA,41411337,Contrasting effects of DNA demethylation on cancer-germline gene expression in breast cancer and leukemia cells.,2025,10.1371/journal.pone.0339460,https://pubmed.ncbi.nlm.nih.gov/41411337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS54,ENSG00000103023,CTA,39208330,"Differential expression and regulation of ADAD1, DMRTC2, PRSS54, SYCE1, SYCP1, TEX101, TEX48, and TMPRSS12 gene profiles in colon cancer tissues and their in vitro response to epigenetic drugs.",2024,10.1371/journal.pone.0307724,https://pubmed.ncbi.nlm.nih.gov/39208330/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS54,ENSG00000103023,CTA,38421455,"Spem2, a novel testis-enriched gene, is required for spermiogenesis and fertilization in mice.",2024,10.1007/s00018-024-05147-w,https://pubmed.ncbi.nlm.nih.gov/38421455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS54,ENSG00000103023,CTA,35863763,Testis-specific serine protease PRSS54 regulates acrosomal granule localization and sperm head morphogenesis in mice†.,2022,10.1093/biolre/ioac146,https://pubmed.ncbi.nlm.nih.gov/35863763/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS54,ENSG00000103023,CTA,31403672,"The testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are dispensable for male mouse fertility†.",2020,10.1093/biolre/ioz158,https://pubmed.ncbi.nlm.nih.gov/31403672/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,42711398,N-terminal thrombospondin-1 enhances muscle function and tissue-specific metabolic adaptation in response to exercise and cold exposure.,2026,10.1038/s12276-026-01830-z,https://pubmed.ncbi.nlm.nih.gov/42711398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,41444608,PRSS55 regulates BCAA metabolism and interacts with BCKDK and BCKDHA in mouse testes and sperm.,2025,10.1186/s13578-025-01511-w,https://pubmed.ncbi.nlm.nih.gov/41444608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,42557768,ADAMTS4 mediates LPS-induced cardiac injury and myocardial fibrosis through proteolytic cleavage of TSP1.,2026,10.1002/ctm2.70769,https://pubmed.ncbi.nlm.nih.gov/42557768/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,40764777,Rescue of male infertility by human PRSS55 in transgenic mice establishes a contraceptive research model.,2025,10.1038/s41598-025-09604-9,https://pubmed.ncbi.nlm.nih.gov/40764777/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,41554713,Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization.,2026,10.1038/s41413-025-00493-2,https://pubmed.ncbi.nlm.nih.gov/41554713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,41197678,Thrombospondin-1 regulates synaptic transmission in hippocampal field CA2 and social behavior in mice.,2025,10.1016/j.nbd.2025.107176,https://pubmed.ncbi.nlm.nih.gov/41197678/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,41533912,CGRP/TSP1 Signaling Dampens Corneal Inflammation and Fibrosis by Targeting A2M During Corneal Stromal Wound Healing.,2026,10.1167/iovs.67.1.10,https://pubmed.ncbi.nlm.nih.gov/41533912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,41594624,Phosphomimetic Thrombospondin-1 Modulates Integrin β1-FAK Signaling and Vascular Cell Functions.,2026,10.3390/biom16010084,https://pubmed.ncbi.nlm.nih.gov/41594624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,41021282,TNAP-induced CD47 membrane expression enhances TGF-β1 conversion in liver fibrosis.,2025,10.1097/hc9.0000000000000781,https://pubmed.ncbi.nlm.nih.gov/41021282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,42778431,Circulating angiogenic and inflammatory biomarkers profiling in patients with hereditary hemorrhagic telangiectasia.,2026,10.1016/j.ejim.2026.107200,https://pubmed.ncbi.nlm.nih.gov/42778431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,41319285,Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive-Like Behaviors.,2026,10.1002/advs.202510780,https://pubmed.ncbi.nlm.nih.gov/41319285/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,41596404,Thrombospondin 1-CD47 Signalling Modulates Vascular Smooth Muscle Cell Senescence in Chronic Kidney Disease.,2026,10.3390/ijms27020755,https://pubmed.ncbi.nlm.nih.gov/41596404/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,41252281,Cell-dependent contributions of thrombospondin-1 to the rupture of abdominal aortic aneurysm in mice.,2026,10.1093/cvr/cvaf243,https://pubmed.ncbi.nlm.nih.gov/41252281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,42271307,Plasma proteomic profiling uncovers the age-related molecular changes in chronic obstructive pulmonary disease.,2026,10.1186/s12890-026-04396-8,https://pubmed.ncbi.nlm.nih.gov/42271307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,41128612,Fibulin-7 in progenitor cells promotes adipose tissue fibrosis and disrupts metabolic homeostasis in obesity.,2026,10.1093/procel/pwaf084,https://pubmed.ncbi.nlm.nih.gov/41128612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,41303525,Targeting the CD47-TSP1 Axis in Abdominal Aortic Aneurysm: A Novel Immunotherapeutic Approach.,2025,10.3390/ijms262211042,https://pubmed.ncbi.nlm.nih.gov/41303525/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,41514867,"Hyperglycemia Modulates the Expression of MAPK13, TSP1, and CXCR2 During Wound Healing in Sprague Dawley Rats.",2025,10.3390/biology15010026,https://pubmed.ncbi.nlm.nih.gov/41514867/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,41523759,Clinical significance of differential plasma proteins levels in the diagnosis of epithelial ovarian cancer.,2025,10.5493/wjem.v15.i3.107711,https://pubmed.ncbi.nlm.nih.gov/41523759/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,40404658,Glioma-neuronal circuit remodeling induces regional immunosuppression.,2025,10.1038/s41467-025-60074-z,https://pubmed.ncbi.nlm.nih.gov/40404658/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,41820365,Megakaryocyte and platelet thrombospondin-1 regulates matrix remodeling by stabilizing basement membrane COL6A1 in lung injury.,2026,10.1038/s41467-026-70489-x,https://pubmed.ncbi.nlm.nih.gov/41820365/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,36418073,Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response.,2022,10.1136/jitc-2022-004712,https://pubmed.ncbi.nlm.nih.gov/36418073/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,40111290,Urine Measurements of the Renin-Angiotensin System-Regulated Proteins Predict Death and Graft Loss in Kidney Transplant Recipients Enrolled in a Ramipril versus Placebo Randomized Controlled Trial.,2025,10.1021/acs.jproteome.4c01100,https://pubmed.ncbi.nlm.nih.gov/40111290/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,37217603,The TSP1-CD47-SIRPα interactome: an immune triangle for the checkpoint era.,2023,10.1007/s00262-023-03465-9,https://pubmed.ncbi.nlm.nih.gov/37217603/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,38339122,PP2A Affects Angiogenesis via Its Interaction with a Novel Phosphorylation Site of TSP1.,2024,10.3390/ijms25031844,https://pubmed.ncbi.nlm.nih.gov/38339122/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,41558567,Topical cream loaded with upcycled citrus bioactive chitosan-pectin nanoparticle protects skin from UV-induced photoaging.,2026,10.1016/j.ijbiomac.2026.150374,https://pubmed.ncbi.nlm.nih.gov/41558567/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,41140164,Interplay Between Thrombospondin-1 and CD36 Modulates Platelet-RBC Interaction in Thrombosis and Abdominal Aneurysm Formation.,2025,10.1161/circresaha.125.326701,https://pubmed.ncbi.nlm.nih.gov/41140164/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,37831763,Thrombospondin-1 proteomimetic polymers exhibit anti-angiogenic activity in a neovascular age-related macular degeneration mouse model.,2023,10.1126/sciadv.adi8534,https://pubmed.ncbi.nlm.nih.gov/37831763/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,42118850,DGAT1 Drives Racially Divergent Fibroblast Activation via ERK1/2-Dependent Tumorigenic Signaling in Prostate Cancer.,2026,10.1158/2767-9764.crc-25-0701,https://pubmed.ncbi.nlm.nih.gov/42118850/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,41513664,Endothelial IRE1α promotes thrombospondin-1 mRNA decay and supports metabolic stress adaptation of pancreatic islets.,2026,10.1038/s41467-025-68276-1,https://pubmed.ncbi.nlm.nih.gov/41513664/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,34439212,Thrombospondin-1 Silencing Improves Lymphocyte Infiltration in Tumors and Response to Anti-PD-1 in Triple-Negative Breast Cancer.,2021,10.3390/cancers13164059,https://pubmed.ncbi.nlm.nih.gov/34439212/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,40596177,Hypoxia preconditioned plasma increases the expression of growth factors to accelerate diabetic wound healing by promoting angiogenesis.,2025,10.1038/s41598-025-04665-2,https://pubmed.ncbi.nlm.nih.gov/40596177/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,38412778,Skin-derived precursor conditioned medium alleviated photoaging via early activation of TGF-β/Smad signaling pathway by thrombospondin1: In vitro and in vivo studies.,2024,10.1016/j.jphotobiol.2024.112873,https://pubmed.ncbi.nlm.nih.gov/38412778/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,38037074,Inhibitory receptor CD47 binding to plasma TSP1 suppresses NK-cell IFN-γ production via activating the JAK/STAT3 pathway during HIV infection.,2023,10.1186/s12967-023-04667-6,https://pubmed.ncbi.nlm.nih.gov/38037074/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,23436708,Scanning of novel cancer/testis proteins by human testis proteomic analysis.,2013,10.1002/pmic.201200489,https://pubmed.ncbi.nlm.nih.gov/23436708/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS55,ENSG00000184647,CTA,18844450,T-SP1: a novel serine protease-like protein predominantly expressed in testis.,2008,10.1515/bc.2008.170,https://pubmed.ncbi.nlm.nih.gov/18844450/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS58,ENSG00000258223,CTA,40281224,Epigenetic markers of disease risk and psychotherapy response in anxiety disorders - a longitudinal analysis of the DNA methylome.,2025,10.1038/s41380-025-03038-5,https://pubmed.ncbi.nlm.nih.gov/40281224/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS58,ENSG00000258223,CTA,38459496,Comparison of the gene expression profile of testicular tissue before and after sexual maturity in Qianbei Ma goats.,2024,10.1186/s12917-024-03932-0,https://pubmed.ncbi.nlm.nih.gov/38459496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS58,ENSG00000258223,CTA,40833463,"Dietary taurine improves antioxidant and lysozyme activity, carbohydrate-related metabolism, and digestive genes expression of longfin yellowtail (Seriola rivoliana).",2025,10.1007/s10695-025-01566-z,https://pubmed.ncbi.nlm.nih.gov/40833463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS58,ENSG00000258223,CTA,35775010,Structural Basis of the Pancreatitis-Associated Autoproteolytic Failsafe Mechanism in Human Anionic Trypsin.,2022,10.2147/jir.s367699,https://pubmed.ncbi.nlm.nih.gov/35775010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS58,ENSG00000258223,CTA,35408828,Structural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin.,2022,10.3390/ijms23073468,https://pubmed.ncbi.nlm.nih.gov/35408828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS58,ENSG00000258223,CTA,32561905,CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity.,2020,10.1093/biolre/ioaa084,https://pubmed.ncbi.nlm.nih.gov/32561905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS58,ENSG00000258223,CTA,28257494,Domestication drive the changes of immune and digestive system of Eurasian perch (Perca fluviatilis).,2017,10.1371/journal.pone.0172903,https://pubmed.ncbi.nlm.nih.gov/28257494/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS58,ENSG00000258223,CTA,30949759,Molecular basis of the digestive functionality in developing Persian sturgeon (Acipenser persicus) larvae: additional clues for its phylogenetic status.,2019,10.1007/s00360-019-01215-x,https://pubmed.ncbi.nlm.nih.gov/30949759/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS58,ENSG00000258223,CTA,31285644,Gene mapping and molecular analysis of hereditarynon-polyposis colorectal cancer (Lynch Syndrome)using systems biological approaches.,2019,10.6026/97320630015269,https://pubmed.ncbi.nlm.nih.gov/31285644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS58,ENSG00000258223,CTA,26582205,Cooperative Interactions of Oligosaccharide and Peptide Moieties of a Glycopeptide Derived from IgE with Galectin-9.,2016,10.1074/jbc.m115.694448,https://pubmed.ncbi.nlm.nih.gov/26582205/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS58,ENSG00000258223,CTA,11391623,Human trypsinogen in colorectal cancer.,2001,10.1002/ijc.1304,https://pubmed.ncbi.nlm.nih.gov/11391623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS58,ENSG00000258223,CTA,27321582,Investigation of urine proteome of preterm newborns with respiratory pathologies.,2016,10.1016/j.jprot.2016.06.012,https://pubmed.ncbi.nlm.nih.gov/27321582/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS58,ENSG00000258223,CTA,25785713,Translational arrest due to cytoplasmic redox stress delays adaptation to growth on methanol and heterologous protein expression in a typical fed-batch culture of Pichia pastoris.,2015,10.1371/journal.pone.0119637,https://pubmed.ncbi.nlm.nih.gov/25785713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS58,ENSG00000258223,CTA,16211415,Serine proteinases of the human body louse (Pediculus humanus): sequence characterization and expression patterns.,2005,10.1007/s00436-005-1463-y,https://pubmed.ncbi.nlm.nih.gov/16211415/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS58,ENSG00000258223,CTA,25182531,Histone deacetylases and phosphorylated polymerase II C-terminal domain recruit Spt6 for cotranscriptional histone reassembly.,2014,10.1128/mcb.00695-14,https://pubmed.ncbi.nlm.nih.gov/25182531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS58,ENSG00000258223,CTA,2067598,"An analogue of growth hormone releasing factor (GRF), (Ac-Try1, D-Phe2)-GRF-(1-29), specifically antagonizes the facilitation of the flexor reflex induced by intrathecal vasoactive intestinal peptide in rat spinal cord.",1991,10.1016/0143-4179(91)90104-q,https://pubmed.ncbi.nlm.nih.gov/2067598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,41067714,PSG1 in Regulating Proliferation and Migration of Human Umbilical Vein Endothelial Cells Through the TGF-β/Orai3 Signaling Pathway.,2025,10.1111/jog.70092,https://pubmed.ncbi.nlm.nih.gov/41067714/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,40494562,Human Platelets Internalize Pregnancy-Specific Glycoprotein-1 (PSG1).,2026,10.1055/a-2618-4817,https://pubmed.ncbi.nlm.nih.gov/40494562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,39121996,Modulation of galectin-9 mediated responses in monocytes and T-cells by pregnancy-specific glycoprotein 1.,2024,10.1016/j.jbc.2024.107638,https://pubmed.ncbi.nlm.nih.gov/39121996/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,40823340,Proteogenomic signature of Alzheimer's disease and related dementia risk in individuals with major depressive disorder.,2025,10.1038/s44220-025-00460-0,https://pubmed.ncbi.nlm.nih.gov/40823340/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,38540713,Pregnancy-Specific Beta-1-Glycoprotein 1 Increases HTR-8/SVneo Cell Migration through the Orai1/Akt Signaling Pathway.,2024,10.3390/biom14030293,https://pubmed.ncbi.nlm.nih.gov/38540713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,39022681,Oligodendrocyte-specific expression of PSG8-AS1 suggests a role in myelination with prognostic value in oligodendroglioma.,2024,10.1016/j.ncrna.2024.06.008,https://pubmed.ncbi.nlm.nih.gov/39022681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,39642651,Role of polysomnography in the management of obstructive sleep apnea during the first year of life in robin sequence: A prospective and longitudinal study.,2025,10.1016/j.sleep.2024.11.041,https://pubmed.ncbi.nlm.nih.gov/39642651/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,39796238,The Molecular Biology of Placental Transport of Calcium to the Human Foetus.,2025,10.3390/ijms26010383,https://pubmed.ncbi.nlm.nih.gov/39796238/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,36309385,High Expression of Pregnancy Specific Beta-1-glycoprotein 1 Is Associated With Poor Gastric Cancer Prognosis.,2022,10.21873/invivo.13005,https://pubmed.ncbi.nlm.nih.gov/36309385/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,40673030,"Pathophysiological mechanisms in severe preeclampsia: role of upregulated proteins in blood pressure, extracellular matrix and immunity.",2025,10.61622/rbgo/2025rbgo54,https://pubmed.ncbi.nlm.nih.gov/40673030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,37475853,A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal-fetal interface.,2023,10.3389/fimmu.2023.1196395,https://pubmed.ncbi.nlm.nih.gov/37475853/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,32546445,Expression of Pregnancy Specific β-1 Glycoprotein 1 in Cervical Cancer Cells.,2020,10.1016/j.arcmed.2020.05.025,https://pubmed.ncbi.nlm.nih.gov/32546445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,35806078,Longitudinal Proteomic Analysis of Plasma across Healthy Pregnancies Reveals Indicators of Gestational Age.,2022,10.3390/ijms23137076,https://pubmed.ncbi.nlm.nih.gov/35806078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,39591637,SLC25A1 regulates placental development to ensure embryonic heart morphogenesis.,2024,10.1242/dev.204290,https://pubmed.ncbi.nlm.nih.gov/39591637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,38732909,In-Laboratory Polysomnography Worsens Obstructive Sleep Apnea by Changing Body Position Compared to Home Testing.,2024,10.3390/s24092803,https://pubmed.ncbi.nlm.nih.gov/38732909/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,36120102,Recombinant pregnancy-specific glycoprotein-1-Fc reduces functional deficit in a mouse model of permanent brain ischaemia.,2022,10.1016/j.bbih.2022.100497,https://pubmed.ncbi.nlm.nih.gov/36120102/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,38411384,Retrospective study of serial polysomnograms of bronchopulmonary dysplasia patients with oxygen dependence.,2024,10.1002/ppul.26930,https://pubmed.ncbi.nlm.nih.gov/38411384/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,35401843,Effects of Pregnancy-Specific Glycoproteins on Trophoblast Motility in Three-Dimensional Gelatin Hydrogels.,2022,10.1007/s12195-021-00715-7,https://pubmed.ncbi.nlm.nih.gov/35401843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,31636515,iTRAQ and PRM-based quantitative proteomics in early recurrent spontaneous abortion: biomarkers discovery.,2019,10.1186/s12014-019-9256-y,https://pubmed.ncbi.nlm.nih.gov/31636515/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,31683744,Interaction of Pregnancy-Specific Glycoprotein 1 With Integrin Α5β1 Is a Modulator of Extravillous Trophoblast Functions.,2019,10.3390/cells8111369,https://pubmed.ncbi.nlm.nih.gov/31683744/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,41862433,Evaluating Sleep Apnea: In-Lab Versus at-Home Recording Time and the Impact of Positional Disease.,2026,10.1002/lary.70517,https://pubmed.ncbi.nlm.nih.gov/41862433/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,32280962,Glycan characterization of pregnancy-specific glycoprotein 1 and its identification as a novel Galectin-1 ligand.,2020,10.1093/glycob/cwaa034,https://pubmed.ncbi.nlm.nih.gov/32280962/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,30253241,Recombinant Pregnancy-Specific Glycoprotein 1 Has a Protective Role in a Murine Model of Acute Graft-versus-Host Disease.,2019,10.1016/j.bbmt.2018.09.022,https://pubmed.ncbi.nlm.nih.gov/30253241/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,27877217,Pregnancy Specific β-1 Glycoprotein 1 is Expressed in Pancreatic Ductal Adenocarcinoma and its Subcellular Localization Correlates with Overall Survival.,2016,10.7150/jca.15864,https://pubmed.ncbi.nlm.nih.gov/27877217/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,30371828,"Activation of latent transforming growth factor-β1, a conserved function for pregnancy-specific beta 1-glycoproteins.",2018,10.1093/molehr/gay044,https://pubmed.ncbi.nlm.nih.gov/30371828/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,34204017,The Efficacy of Lingual Laser Frenectomy in Pediatric OSAS: A Randomized Double-Blinded and Controlled Clinical Study.,2021,10.3390/ijerph18116112,https://pubmed.ncbi.nlm.nih.gov/34204017/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,25548275,Induction and activation of latent transforming growth factor-β1 are carried out by two distinct domains of pregnancy-specific glycoprotein 1 (PSG1).,2015,10.1074/jbc.m114.597518,https://pubmed.ncbi.nlm.nih.gov/25548275/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,23945545,Pregnancy-specific glycoprotein 1 (PSG1) activates TGF-β and prevents dextran sodium sulfate (DSS)-induced colitis in mice.,2014,10.1038/mi.2013.53,https://pubmed.ncbi.nlm.nih.gov/23945545/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,29377892,Network-based co-expression analysis for exploring the potential diagnostic biomarkers of metastatic melanoma.,2018,10.1371/journal.pone.0190447,https://pubmed.ncbi.nlm.nih.gov/29377892/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,21193412,Pregnancy-specific glycoprotein 1 induces endothelial tubulogenesis through interaction with cell surface proteoglycans.,2011,10.1074/jbc.m110.161810,https://pubmed.ncbi.nlm.nih.gov/21193412/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG1,ENSG00000231924,CTA,20335639,Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis.,2010,10.1095/biolreprod.109.082412,https://pubmed.ncbi.nlm.nih.gov/20335639/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG11,ENSG00000243130,CTA,37715129,Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy.,2023,10.1186/s12014-023-09425-w,https://pubmed.ncbi.nlm.nih.gov/37715129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG11,ENSG00000243130,CTA,33452729,Depletion of CTCF disrupts PSG gene expression in the human trophoblast cell line Swan 71.,2021,10.1002/2211-5463.13087,https://pubmed.ncbi.nlm.nih.gov/33452729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG11,ENSG00000243130,CTA,34717543,Fusobacterium nucleatum predicts a high risk of metastasis for esophageal squamous cell carcinoma.,2021,10.1186/s12866-021-02352-6,https://pubmed.ncbi.nlm.nih.gov/34717543/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG11,ENSG00000243130,CTA,25551281,Integrative network analysis of TCGA data for ovarian cancer.,2014,10.1186/s12918-014-0136-9,https://pubmed.ncbi.nlm.nih.gov/25551281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG11,ENSG00000243130,CTA,22748001,Genome-wide association study identifies a maternal copy-number deletion in PSG11 enriched among preeclampsia patients.,2012,10.1186/1471-2393-12-61,https://pubmed.ncbi.nlm.nih.gov/22748001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG11,ENSG00000243130,CTA,10326620,Pregnancy-specific glycoprotein gene expression in recurrent aborters: a potential correlation to interleukin-10 expression.,1999,10.1111/j.1600-0897.1999.tb00530.x,https://pubmed.ncbi.nlm.nih.gov/10326620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG11,ENSG00000243130,CTA,8232246,Expression of pregnancy-specific beta 1-glycoprotein genes in hematopoietic cells.,1993,10.1007/bf01076099,https://pubmed.ncbi.nlm.nih.gov/8232246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG11,ENSG00000243130,CTA,8006022,Subtle differences in human pregnancy-specific glycoprotein gene promoters allow for differential expression.,1994,10.1016/s0021-9258(17)32534-6,https://pubmed.ncbi.nlm.nih.gov/8006022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG11,ENSG00000243130,CTA,8003489,Pregnancy-specific glycoprotein gene expression and the induction by 5-bromo-2'-deoxyuridine.,1994,10.1021/bi00189a030,https://pubmed.ncbi.nlm.nih.gov/8003489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG11,ENSG00000243130,CTA,2050678,Molecular cloning of nonspecific cross-reacting antigens in human granulocytes.,1991,10.1016/s0021-9258(18)99029-0,https://pubmed.ncbi.nlm.nih.gov/2050678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,42573986,PSG2 Impairs Human Trophoblast Function in Preeclampsia by Activating TGF-β/Smad3 to Suppress EMT and MMP2/9 Expression.,2026,10.1093/biolre/ioag168,https://pubmed.ncbi.nlm.nih.gov/42573986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,38680176,Aberrant methylation of placental development genes in chorionic villi of spontaneous abortions with trisomy 16.,2024,10.18699/vjgb-24-24,https://pubmed.ncbi.nlm.nih.gov/38680176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,39642651,Role of polysomnography in the management of obstructive sleep apnea during the first year of life in robin sequence: A prospective and longitudinal study.,2025,10.1016/j.sleep.2024.11.041,https://pubmed.ncbi.nlm.nih.gov/39642651/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,38411384,Retrospective study of serial polysomnograms of bronchopulmonary dysplasia patients with oxygen dependence.,2024,10.1002/ppul.26930,https://pubmed.ncbi.nlm.nih.gov/38411384/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,37715129,Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy.,2023,10.1186/s12014-023-09425-w,https://pubmed.ncbi.nlm.nih.gov/37715129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,37708957,Rosuvastatin effects on the HDL proteome in hyperlipidemic patients.,2023,10.2478/acph-2023-0034,https://pubmed.ncbi.nlm.nih.gov/37708957/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,33452729,Depletion of CTCF disrupts PSG gene expression in the human trophoblast cell line Swan 71.,2021,10.1002/2211-5463.13087,https://pubmed.ncbi.nlm.nih.gov/33452729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,29930344,Krüppel-Like Factor 10 participates in cervical cancer immunoediting through transcriptional regulation of Pregnancy-Specific Beta-1 Glycoproteins.,2018,10.1038/s41598-018-27711-8,https://pubmed.ncbi.nlm.nih.gov/29930344/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,34204017,The Efficacy of Lingual Laser Frenectomy in Pediatric OSAS: A Randomized Double-Blinded and Controlled Clinical Study.,2021,10.3390/ijerph18116112,https://pubmed.ncbi.nlm.nih.gov/34204017/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,36126144,Proteomic Analysis of Effects of Spironolactone in Heart Failure With Preserved Ejection Fraction.,2022,10.1161/circheartfailure.121.009693,https://pubmed.ncbi.nlm.nih.gov/36126144/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,23831324,"Absence of systemic toxicity changes following intramuscular administration of novel pSG2.HIVconsv DNA, ChAdV63.HIVconsv and MVA.HIVconsv vaccines to BALB/c mice.",2013,10.1016/j.vaccine.2013.06.068,https://pubmed.ncbi.nlm.nih.gov/23831324/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,21339297,Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm.,2011,10.1074/jbc.m110.175463,https://pubmed.ncbi.nlm.nih.gov/21339297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,31284791,Screening of serum biomarkers of preeclampsia by proteomics combination with bioinformatics.,2019,10.1080/10641955.2019.1640246,https://pubmed.ncbi.nlm.nih.gov/31284791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,24374353,Genetic control of specificity to steroid-triggered responses in Drosophila.,2014,10.1534/genetics.113.159707,https://pubmed.ncbi.nlm.nih.gov/24374353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,24375464,Predominantly placenta-expressed mRNAs in maternal plasma as predictive markers for twin-twin transfusion syndrome.,2014,10.1002/pd.4307,https://pubmed.ncbi.nlm.nih.gov/24375464/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,30055481,A systematic comparison of factors that could impact treatment recommendations for patients with Positional Obstructive Sleep Apnea (POSA).,2018,10.1016/j.sleep.2018.05.012,https://pubmed.ncbi.nlm.nih.gov/30055481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,19750919,Excessive muscle activity increases over time in idiopathic REM sleep behavior disorder.,2009,10.1093/sleep/32.9.1149,https://pubmed.ncbi.nlm.nih.gov/19750919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,19047058,Tyrosylprotein sulfotransferase-2 expression is required for sulfation of RNase 9 and Mfge8 in vivo.,2009,10.1074/jbc.m808434200,https://pubmed.ncbi.nlm.nih.gov/19047058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,28711367,Optimization of a multigene biochip for detection of relapsed and early relapsed colorectal cancer.,2017,10.1016/j.jss.2017.06.030,https://pubmed.ncbi.nlm.nih.gov/28711367/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,25007091,"Safety and tolerability of conserved region vaccines vectored by plasmid DNA, simian adenovirus and modified vaccinia virus ankara administered to human immunodeficiency virus type 1-uninfected adults in a randomized, single-blind phase I trial.",2014,10.1371/journal.pone.0101591,https://pubmed.ncbi.nlm.nih.gov/25007091/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,21347224,"Partially randomized, non-blinded trial of DNA and MVA therapeutic vaccines based on hepatitis B virus surface protein for chronic HBV infection.",2011,10.1371/journal.pone.0014626,https://pubmed.ncbi.nlm.nih.gov/21347224/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,22095198,Prime-boost regimens with adjuvanted synthetic long peptides elicit T cells and antibodies to conserved regions of HIV-1 in macaques.,2012,10.1097/qad.0b013e32834ed9b2,https://pubmed.ncbi.nlm.nih.gov/22095198/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,28183547,Effects of dexmedetomidine administered for postoperative analgesia on sleep quality in patients undergoing abdominal hysterectomy.,2017,10.1016/j.jclinane.2016.10.022,https://pubmed.ncbi.nlm.nih.gov/28183547/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,21256800,A convenient expiratory positive airway pressure nasal device for the treatment of sleep apnea in patients non-adherent with continuous positive airway pressure.,2011,10.1016/j.sleep.2010.06.011,https://pubmed.ncbi.nlm.nih.gov/21256800/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG2,ENSG00000242221,CTA,9272910,"Obstructive sleep apnoea syndrome: is the ""half-night polysomnography"" an adequate method for evaluating sleep profile and respiratory events?",1997,10.1183/09031936.97.10081725,https://pubmed.ncbi.nlm.nih.gov/9272910/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,38677710,Multiplexed serum biomarkers to discriminate nonviable and ectopic pregnancy.,2024,10.1016/j.fertnstert.2024.04.028,https://pubmed.ncbi.nlm.nih.gov/38677710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,40257008,Pregnancy-specific glycoproteins as potential drug targets for female lung adenocarcinoma patients.,2025,10.1093/bfgp/elaf004,https://pubmed.ncbi.nlm.nih.gov/40257008/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,38732909,In-Laboratory Polysomnography Worsens Obstructive Sleep Apnea by Changing Body Position Compared to Home Testing.,2024,10.3390/s24092803,https://pubmed.ncbi.nlm.nih.gov/38732909/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,40270429,"Phosphorothioate-Modified Hairpin G-Triplex Reporter-Assisted Split CRISPR/Cas12a-Powered Biosensor for ""Turn-On"" Fluorescent Detection of Nucleic Acid and Non-Nucleic Acid Targets.",2025,10.1021/acs.analchem.5c00140,https://pubmed.ncbi.nlm.nih.gov/40270429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,38411384,Retrospective study of serial polysomnograms of bronchopulmonary dysplasia patients with oxygen dependence.,2024,10.1002/ppul.26930,https://pubmed.ncbi.nlm.nih.gov/38411384/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,34880956,Identification of KLF6/PSGs and NPY-Related USF2/CEACAM Transcriptional Regulatory Networks via Spinal Cord Bulk and Single-Cell RNA-Seq Analysis.,2021,10.1155/2021/2826609,https://pubmed.ncbi.nlm.nih.gov/34880956/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,37715129,Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy.,2023,10.1186/s12014-023-09425-w,https://pubmed.ncbi.nlm.nih.gov/37715129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,38525106,Development of a SARS-CoV-2 neutralization assay based on a pseudotyped virus using a HIV system.,2024,10.1002/mco2.517,https://pubmed.ncbi.nlm.nih.gov/38525106/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,35646058,"Placental Gene Transcript Proportions are Altered in the Presence of In Utero Arsenic and Cadmium Exposures, Genetic Variants, and Birth Weight Differences.",2022,10.3389/fgene.2022.865449,https://pubmed.ncbi.nlm.nih.gov/35646058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,35797939,Gestational SARS-CoV-2 infection is associated with placental expression of immune and trophoblast genes.,2022,10.1016/j.placenta.2022.06.017,https://pubmed.ncbi.nlm.nih.gov/35797939/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,24375464,Predominantly placenta-expressed mRNAs in maternal plasma as predictive markers for twin-twin transfusion syndrome.,2014,10.1002/pd.4307,https://pubmed.ncbi.nlm.nih.gov/24375464/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,28212692,Oxygen Desaturation Index Differs Significantly Between Types of Sleep Software.,2017,10.5664/jcsm.6552,https://pubmed.ncbi.nlm.nih.gov/28212692/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,25537765,A novel regulator of human villous trophoblast fusion: the Krüppel-like factor 6.,2015,10.1093/molehr/gau113,https://pubmed.ncbi.nlm.nih.gov/25537765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,20116096,Expression and transcriptional regulation of individual pregnancy-specific glycoprotein genes in differentiating trophoblast cells.,2010,10.1016/j.placenta.2010.01.004,https://pubmed.ncbi.nlm.nih.gov/20116096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,21799854,Krüppel-like factor 6 expression changes during trophoblast syncytialization and transactivates ßhCG and PSG placental genes.,2011,10.1371/journal.pone.0022438,https://pubmed.ncbi.nlm.nih.gov/21799854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,20092892,Effect of maternal tobacco smoke exposure on the placental transcriptome.,2010,10.1016/j.placenta.2009.12.016,https://pubmed.ncbi.nlm.nih.gov/20092892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,15450385,Differential display RT-PCR analysis of human choriocarcinoma cell lines and normal term trophoblast cells: identification of new genes expressed in placenta.,2004,10.1016/j.placenta.2003.10.020,https://pubmed.ncbi.nlm.nih.gov/15450385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,17416428,High throughput functional analysis of HIV-1 env genes without cloning.,2007,10.1016/j.jviromet.2007.02.015,https://pubmed.ncbi.nlm.nih.gov/17416428/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,19769157,[The impact of the HIV-1 envelope (Env) mutation on its assembly of functional pseudovirus].,2009,,https://pubmed.ncbi.nlm.nih.gov/19769157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,10193445,Effect of pregnancy-specific beta 1-glycoprotein on the development of preimplantation embryo.,1999,10.1046/j.1525-1373.1999.d01-25.x,https://pubmed.ncbi.nlm.nih.gov/10193445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,28183547,Effects of dexmedetomidine administered for postoperative analgesia on sleep quality in patients undergoing abdominal hysterectomy.,2017,10.1016/j.jclinane.2016.10.022,https://pubmed.ncbi.nlm.nih.gov/28183547/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG3,ENSG00000221826,CTA,21256800,A convenient expiratory positive airway pressure nasal device for the treatment of sleep apnea in patients non-adherent with continuous positive airway pressure.,2011,10.1016/j.sleep.2010.06.011,https://pubmed.ncbi.nlm.nih.gov/21256800/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,42134299,PSG6: A mitochondrially-targeted gentisic acid derivative exerts antiplatelet action via mitochondrial complex I inhibition.,2026,10.1016/j.redox.2026.104200,https://pubmed.ncbi.nlm.nih.gov/42134299/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,41340289,H&lt;sub&gt;2&lt;/sub&gt;S Click Delivery: Responsive Release for Multidimensional Therapy of Thoracic Aortic Dissection.,2026,10.1002/adhm.202503768,https://pubmed.ncbi.nlm.nih.gov/41340289/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,41674925,&lt;i&gt;CREM&lt;/i&gt; regulates the tumor immune microenvironment and predicts prognosis in thyroid carcinoma.,2026,10.21037/tcr-2025-1673,https://pubmed.ncbi.nlm.nih.gov/41674925/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,39022681,Oligodendrocyte-specific expression of PSG8-AS1 suggests a role in myelination with prognostic value in oligodendroglioma.,2024,10.1016/j.ncrna.2024.06.008,https://pubmed.ncbi.nlm.nih.gov/39022681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,37831187,Pregnancy-specific beta-1-glycoprotein 6 is a potential novel diagnostic biomarker of placenta accreta spectrum.,2024,10.1007/s00795-023-00371-y,https://pubmed.ncbi.nlm.nih.gov/37831187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,37715129,Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy.,2023,10.1186/s12014-023-09425-w,https://pubmed.ncbi.nlm.nih.gov/37715129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,33452729,Depletion of CTCF disrupts PSG gene expression in the human trophoblast cell line Swan 71.,2021,10.1002/2211-5463.13087,https://pubmed.ncbi.nlm.nih.gov/33452729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,32034058,Integrated characterisation of cancer genes identifies key molecular biomarkers in stomach adenocarcinoma.,2020,10.1136/jclinpath-2019-206400,https://pubmed.ncbi.nlm.nih.gov/32034058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,33065549,Pro-angiogenic effects of pregnancy-specific glycoproteins in endothelial and extravillous trophoblast cells.,2020,10.1530/rep-20-0169,https://pubmed.ncbi.nlm.nih.gov/33065549/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,27447975,Molecular mechanisms of OLIG2 transcription factor in brain cancer.,2016,10.18632/oncotarget.10628,https://pubmed.ncbi.nlm.nih.gov/27447975/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,26869332,Gestational diabetic transcriptomic profiling of microdissected human trophoblast.,2016,10.1530/joe-15-0424,https://pubmed.ncbi.nlm.nih.gov/26869332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,20069890,[Cloning and expressing of a harpin-encoding gene from Pseudomonas syringae pv. glycinea].,2009,,https://pubmed.ncbi.nlm.nih.gov/20069890/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,8006022,Subtle differences in human pregnancy-specific glycoprotein gene promoters allow for differential expression.,1994,10.1016/s0021-9258(17)32534-6,https://pubmed.ncbi.nlm.nih.gov/8006022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,2377620,Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole.,1990,10.1073/pnas.87.15.5822,https://pubmed.ncbi.nlm.nih.gov/2377620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,8349632,Characterization of two allelic variants of a human pregnancy-specific glycoprotein gene.,1993,10.1016/s0021-9258(19)85365-6,https://pubmed.ncbi.nlm.nih.gov/8349632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,7765445,The application of luciferase as a reporter of environmental regulation of gene expression in mycobacteria.,1994,10.1111/j.1472-765x.1994.tb00469.x,https://pubmed.ncbi.nlm.nih.gov/7765445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,1318503,Immortalization of virus-free human placental cells that express tissue-specific functions.,1992,10.1210/mend.6.5.1318503,https://pubmed.ncbi.nlm.nih.gov/1318503/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,2271648,Characterization of two new members of the pregnancy-specific beta 1-glycoprotein family from the myeloid cell line KG-1 and suggestion of two distinct classes of transcription unit.,1990,10.1021/bi00496a009,https://pubmed.ncbi.nlm.nih.gov/2271648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,8003489,Pregnancy-specific glycoprotein gene expression and the induction by 5-bromo-2'-deoxyuridine.,1994,10.1021/bi00189a030,https://pubmed.ncbi.nlm.nih.gov/8003489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG6,ENSG00000170848,CTA,2783133,"cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver.",1989,10.1016/0006-291x(89)91105-4,https://pubmed.ncbi.nlm.nih.gov/2783133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG7,ENSG00000221878,CTA,36276966,PSG7 indicates that age at diagnosis is associated with papillary thyroid carcinoma: A study based on the cancer genome atlas data.,2022,10.3389/fgene.2022.952981,https://pubmed.ncbi.nlm.nih.gov/36276966/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG7,ENSG00000221878,CTA,40991151,Proteome-Wide Mendelian Randomisation Study of Adverse Perinatal Outcomes.,2025,10.1007/s10519-025-10233-1,https://pubmed.ncbi.nlm.nih.gov/40991151/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG7,ENSG00000221878,CTA,40257008,Pregnancy-specific glycoproteins as potential drug targets for female lung adenocarcinoma patients.,2025,10.1093/bfgp/elaf004,https://pubmed.ncbi.nlm.nih.gov/40257008/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG7,ENSG00000221878,CTA,35322669,PSG7 and 9 (Pregnancy-Specific β-1 Glycoproteins 7 and 9): Novel Biomarkers for Preeclampsia.,2022,10.1161/jaha.121.024536,https://pubmed.ncbi.nlm.nih.gov/35322669/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG7,ENSG00000221878,CTA,38870367,Study of the genomics and transcriptomics profiles of male-infertility genes in human prostate cancer: an in silico analysis.,2024,10.1080/19396368.2024.2354305,https://pubmed.ncbi.nlm.nih.gov/38870367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG7,ENSG00000221878,CTA,38911338,Integrated Analysis Reveals COL4A3 as a Novel Diagnostic and Therapeutic Target in UV-Related Skin Cutaneous Melanoma.,2024,10.2147/ccid.s461959,https://pubmed.ncbi.nlm.nih.gov/38911338/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG7,ENSG00000221878,CTA,35678669,Protocol for Increasing the Sensitivity of MS-Based Protein Detection in Human Chorionic Villi.,2022,10.3390/cimb44050140,https://pubmed.ncbi.nlm.nih.gov/35678669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG7,ENSG00000221878,CTA,32117443,Identification of the Prognosis-Related lncRNAs and Genes in Gastric Cancer.,2020,10.3389/fgene.2020.00027,https://pubmed.ncbi.nlm.nih.gov/32117443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG7,ENSG00000221878,CTA,19562724,The FOXF2 pathway in the human prostate stroma.,2009,10.1002/pros.20996,https://pubmed.ncbi.nlm.nih.gov/19562724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG7,ENSG00000221878,CTA,20116096,Expression and transcriptional regulation of individual pregnancy-specific glycoprotein genes in differentiating trophoblast cells.,2010,10.1016/j.placenta.2010.01.004,https://pubmed.ncbi.nlm.nih.gov/20116096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG7,ENSG00000221878,CTA,14761676,"2,3,7,8-tetrachlorodibenzo-p-dioxin augments the modulation of gene expression mediated by the thyroid hormone receptor.",2004,10.1016/j.taap.2003.09.010,https://pubmed.ncbi.nlm.nih.gov/14761676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG7,ENSG00000221878,CTA,1690992,The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed.,1990,10.1016/0006-291x(90)92103-7,https://pubmed.ncbi.nlm.nih.gov/1690992/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG8,ENSG00000124467,CTA,39022681,Oligodendrocyte-specific expression of PSG8-AS1 suggests a role in myelination with prognostic value in oligodendroglioma.,2024,10.1016/j.ncrna.2024.06.008,https://pubmed.ncbi.nlm.nih.gov/39022681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG8,ENSG00000124467,CTA,40257008,Pregnancy-specific glycoproteins as potential drug targets for female lung adenocarcinoma patients.,2025,10.1093/bfgp/elaf004,https://pubmed.ncbi.nlm.nih.gov/40257008/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG8,ENSG00000124467,CTA,37715129,Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy.,2023,10.1186/s12014-023-09425-w,https://pubmed.ncbi.nlm.nih.gov/37715129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG8,ENSG00000124467,CTA,33452729,Depletion of CTCF disrupts PSG gene expression in the human trophoblast cell line Swan 71.,2021,10.1002/2211-5463.13087,https://pubmed.ncbi.nlm.nih.gov/33452729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG8,ENSG00000124467,CTA,25556502,Long non-coding RNAs are differentially expressed in hepatocellular carcinoma cell lines with differing metastatic potential.,2014,10.7314/apjcp.2014.15.23.10513,https://pubmed.ncbi.nlm.nih.gov/25556502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,41796334,Endogenous retroviral elements LTR8B and MER65 rewire PSG9 regulation to control trophoblast syncytialization and pre-eclampsia risk.,2026,10.1186/s13059-026-03944-z,https://pubmed.ncbi.nlm.nih.gov/41796334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,42725300,Unmasking the invisible: Proteomic traces of depression in human serum - A pilot study.,2026,10.4103/indianjpsychiatry_975_25,https://pubmed.ncbi.nlm.nih.gov/42725300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,36980442,Pregnancy-Specific Glycoprotein 9 Enhances Store-Operated Calcium Entry and Nitric Oxide Release in Human Umbilical Vein Endothelial Cells.,2023,10.3390/diagnostics13061134,https://pubmed.ncbi.nlm.nih.gov/36980442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,39796238,The Molecular Biology of Placental Transport of Calcium to the Human Foetus.,2025,10.3390/ijms26010383,https://pubmed.ncbi.nlm.nih.gov/39796238/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,40948775,Novel proteomics biomarkers of recurrent pregnancy loss reflect the dysregulation of immune interactions at the maternal-fetal interface.,2025,10.3389/fimmu.2025.1621168,https://pubmed.ncbi.nlm.nih.gov/40948775/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,37715129,Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy.,2023,10.1186/s12014-023-09425-w,https://pubmed.ncbi.nlm.nih.gov/37715129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,33452729,Depletion of CTCF disrupts PSG gene expression in the human trophoblast cell line Swan 71.,2021,10.1002/2211-5463.13087,https://pubmed.ncbi.nlm.nih.gov/33452729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,35322669,PSG7 and 9 (Pregnancy-Specific β-1 Glycoproteins 7 and 9): Novel Biomarkers for Preeclampsia.,2022,10.1161/jaha.121.024536,https://pubmed.ncbi.nlm.nih.gov/35322669/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,33377651,Pregnancy-specific glycoprotein 9 acts as both a transcriptional target and a regulator of the canonical TGF-β/Smad signaling to drive breast cancer progression.,2020,10.1002/ctm2.245,https://pubmed.ncbi.nlm.nih.gov/33377651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,35401843,Effects of Pregnancy-Specific Glycoproteins on Trophoblast Motility in Three-Dimensional Gelatin Hydrogels.,2022,10.1007/s12195-021-00715-7,https://pubmed.ncbi.nlm.nih.gov/35401843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,33824285,TFAP2A potentiates lung adenocarcinoma metastasis by a novel miR-16 family/TFAP2A/PSG9/TGF-β signaling pathway.,2021,10.1038/s41419-021-03606-x,https://pubmed.ncbi.nlm.nih.gov/33824285/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,27528036,"Pregnancy-specific glycoprotein 9 (PSG9), a driver for colorectal cancer, enhances angiogenesis via activation of SMAD4.",2016,10.18632/oncotarget.11146,https://pubmed.ncbi.nlm.nih.gov/27528036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,34717543,Fusobacterium nucleatum predicts a high risk of metastasis for esophageal squamous cell carcinoma.,2021,10.1186/s12866-021-02352-6,https://pubmed.ncbi.nlm.nih.gov/34717543/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,32953262,Serum proteins differentially expressed in early- and late-onset preeclampsia assessed using iTRAQ proteomics and bioinformatics analyses.,2020,10.7717/peerj.9753,https://pubmed.ncbi.nlm.nih.gov/32953262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,27389696,PSG9 Stimulates Increase in FoxP3+ Regulatory T-Cells through the TGF-β1 Pathway.,2016,10.1371/journal.pone.0158050,https://pubmed.ncbi.nlm.nih.gov/27389696/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,28078509,PSG9 promotes angiogenesis by stimulating VEGFA production and is associated with poor prognosis in hepatocellular carcinoma.,2017,10.1007/s11427-016-0226-7,https://pubmed.ncbi.nlm.nih.gov/28078509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,26896894,"Octylphenol induced gene expression in testes of Frog, Rana chensinensis.",2016,10.1016/j.ecoenv.2016.02.013,https://pubmed.ncbi.nlm.nih.gov/26896894/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,32596059,Alveolar soft-part sarcoma (ASPS) resembles a mesenchymal stromal progenitor: evidence from meta-analysis of transcriptomic data.,2020,10.7717/peerj.9394,https://pubmed.ncbi.nlm.nih.gov/32596059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,33065549,Pro-angiogenic effects of pregnancy-specific glycoproteins in endothelial and extravillous trophoblast cells.,2020,10.1530/rep-20-0169,https://pubmed.ncbi.nlm.nih.gov/33065549/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,33415446,Whole exome sequencing and establishment of an organoid culture of the carcinoma showing thymus-like differentiation (CASTLE) of the parotid gland.,2021,10.1007/s00428-020-02981-8,https://pubmed.ncbi.nlm.nih.gov/33415446/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG9,ENSG00000183668,CTA,30371828,"Activation of latent transforming growth factor-β1, a conserved function for pregnancy-specific beta 1-glycoproteins.",2018,10.1093/molehr/gay044,https://pubmed.ncbi.nlm.nih.gov/30371828/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,42854377,Meiotic recombination proteins in cancer.,2026,10.1016/j.dnarep.2026.103963,https://pubmed.ncbi.nlm.nih.gov/42854377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,41098129,RAD21L1 Is Sufficient and Effective for Reprogramming Human Sertoli Cells to Phenotypic Spermatogonial Stem Cells Through DNA Methylation and Essential for Male Fertility.,2025,10.1002/advs.202417491,https://pubmed.ncbi.nlm.nih.gov/41098129/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,41032613,Meiotic cohesin RAD21L shapes 3D genome structure and transcription in the male germline.,2025,10.1126/sciadv.adv2283,https://pubmed.ncbi.nlm.nih.gov/41032613/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,39928879,Dynamic changes in histone lysine lactylation during meiosis prophase I in mouse spermatogenesis.,2025,10.1073/pnas.2418693122,https://pubmed.ncbi.nlm.nih.gov/39928879/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,36740274,"Analysis of absolute amounts of two meiotic cohesin subunits, RAD21L and REC8, in mouse spermatocytes.",2023,10.1262/jrd.2022-075,https://pubmed.ncbi.nlm.nih.gov/36740274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,34138874,Rad21l1 cohesin subunit is dispensable for spermatogenesis but not oogenesis in zebrafish.,2021,10.1371/journal.pgen.1009127,https://pubmed.ncbi.nlm.nih.gov/34138874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,40709334,Differential effects of Mediterranean vs. Western diets on coronary atherosclerosis and peripheral artery transcriptomics.,2025,10.3389/fnut.2025.1564741,https://pubmed.ncbi.nlm.nih.gov/40709334/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,36179046,Ectopic expression of meiotic cohesin generates chromosome instability in cancer cell line.,2022,10.1073/pnas.2204071119,https://pubmed.ncbi.nlm.nih.gov/36179046/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,38738460,Short report: Twins with 20p13 duplication. Case report and comprehensive literature review.,2024,10.1002/mgg3.2436,https://pubmed.ncbi.nlm.nih.gov/38738460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,34599968,Loss of TDP-43 in male germ cells causes meiotic failure and impairs fertility in mice.,2021,10.1016/j.jbc.2021.101231,https://pubmed.ncbi.nlm.nih.gov/34599968/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,32931493,Meiotic cohesins mediate initial loading of HORMAD1 to the chromosomes and coordinate SC formation during meiotic prophase.,2020,10.1371/journal.pgen.1009048,https://pubmed.ncbi.nlm.nih.gov/32931493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,39336750,Positive Selection Drives the Evolution of the Structural Maintenance of Chromosomes (SMC) Complexes.,2024,10.3390/genes15091159,https://pubmed.ncbi.nlm.nih.gov/39336750/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,32917770,Low tolerance for transcriptional variation at cohesin genes is accompanied by functional links to disease-relevant pathways.,2021,10.1136/jmedgenet-2020-107095,https://pubmed.ncbi.nlm.nih.gov/32917770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,32741963,Genetic dissection of spermatogenic arrest through exome analysis: clinical implications for the management of azoospermic men.,2020,10.1038/s41436-020-0907-1,https://pubmed.ncbi.nlm.nih.gov/32741963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,37650378,The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1.,2023,10.7554/elife.84138,https://pubmed.ncbi.nlm.nih.gov/37650378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,28239026,Ectopic expression of meiotic cohesin RAD21L promotes adjacency of homologous chromosomes in somatic cells.,2017,10.1262/jrd.2016-171,https://pubmed.ncbi.nlm.nih.gov/28239026/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,27792785,Distinct Roles of Meiosis-Specific Cohesin Complexes in Mammalian Spermatogenesis.,2016,10.1371/journal.pgen.1006389,https://pubmed.ncbi.nlm.nih.gov/27792785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,34237181,Zebrafish intestinal transcriptome highlights subdued inflammatory responses to dietary soya bean and efficacy of yeast β-glucan.,2021,10.1111/jfd.13484,https://pubmed.ncbi.nlm.nih.gov/34237181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,27172213,"Genetic Interactions Between the Meiosis-Specific Cohesin Components, STAG3, REC8, and RAD21L.",2016,10.1534/g3.116.029462,https://pubmed.ncbi.nlm.nih.gov/27172213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,28635411,Single-nucleotide polymorphisms in the human RAD21L gene may be a genetic risk factor for Japanese patients with azoospermia caused by meiotic arrest and Sertoli cell-only syndrome.,2017,10.1080/14647273.2017.1292004,https://pubmed.ncbi.nlm.nih.gov/28635411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,21311562,"Cohesin subunit Rad21L, the new kid on the block has new ideas.",2011,10.1038/embor.2011.24,https://pubmed.ncbi.nlm.nih.gov/21311562/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,25526461,Profile of differential promoter activity by nucleotide substitution at GWAS signals for multiple sclerosis.,2014,10.1097/md.0000000000000281,https://pubmed.ncbi.nlm.nih.gov/25526461/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD21L1,ENSG00000244588,CTA,25408876,Cohesin complexes with a potential to link mammalian meiosis to cancer.,2013,10.1186/2045-9769-2-4,https://pubmed.ncbi.nlm.nih.gov/25408876/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP2,ENSG00000214842,CTA,36153927,A novel homozygous loss-of-function mutation in RAD51AP2 induces male infertility with nonobstructive azoospermia.,2023,10.4103/aja202272,https://pubmed.ncbi.nlm.nih.gov/36153927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP2,ENSG00000214842,CTA,35020426,RAD51AP2 is required for efficient meiotic recombination between X and Y chromosomes.,2022,10.1126/sciadv.abk1789,https://pubmed.ncbi.nlm.nih.gov/35020426/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP2,ENSG00000214842,CTA,36979826,Characteristic Analysis of Featured Genes Associated with Cholangiocarcinoma Progression.,2023,10.3390/biomedicines11030847,https://pubmed.ncbi.nlm.nih.gov/36979826/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP2,ENSG00000214842,CTA,37542770,Alectinib relieves ischemic strokes caused by left atrial metastasis in a NSCLC patient with a novel SLC34A2-ALK (exon 1: exon 15) fusion.,2023,10.1016/j.lungcan.2023.107289,https://pubmed.ncbi.nlm.nih.gov/37542770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP2,ENSG00000214842,CTA,34173924,Immunogenomic profiling and pathological response results from a clinical trial of docetaxel and carboplatin in triple-negative breast cancer.,2021,10.1007/s10549-021-06307-3,https://pubmed.ncbi.nlm.nih.gov/34173924/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP2,ENSG00000214842,CTA,16990250,"RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51.",2006,10.1093/nar/gkl665,https://pubmed.ncbi.nlm.nih.gov/16990250/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP2,ENSG00000214842,CTA,29989002,An Exome-wide Association Study for Type 2 Diabetes-Attributed End-Stage Kidney Disease in African Americans.,2018,10.1016/j.ekir.2018.03.002,https://pubmed.ncbi.nlm.nih.gov/29989002/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,42291182,A mechanism of target mRNA selection and activity regulation in meiosis-related RBM46-MEIOC-YTHDC2 complex.,2026,10.1016/j.isci.2026.116234,https://pubmed.ncbi.nlm.nih.gov/42291182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,42479652,Molecular genetics of meiotic initiation in mammals.,2026,10.1093/biolre/ioag155,https://pubmed.ncbi.nlm.nih.gov/42479652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,41836594,"Methylation and Expression Analysis of POU4F2, HOXA9, RBM46, and TSGA10 Genes in Bladder Cancer Using Methyl-Sensitive Restriction Enzyme PCR (MSRE-PCR).",2026,10.2147/cmar.s557943,https://pubmed.ncbi.nlm.nih.gov/41836594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,42217413,RBM46 promotes meiotic initiation during oogenesis.,2026,10.1016/j.bbrc.2026.154058,https://pubmed.ncbi.nlm.nih.gov/42217413/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,42399815,O-GlcNAc transferase governs spermatogenic mitotic-to-meiotic transition and progression by coordinating transcription and alternative splicing programs.,2026,10.1186/s11658-026-00972-2,https://pubmed.ncbi.nlm.nih.gov/42399815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,42899482,Tumour Antigen-Specific Antibody Signatures as Diagnostic Biomarkers for Melanoma.,2026,10.1002/ijc.70726,https://pubmed.ncbi.nlm.nih.gov/42899482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,41463826,Comparative Transcriptomic Analysis of Male and Female Gonads in &lt;i&gt;Hemibagrus guttatus&lt;/i&gt; (Lacepède).,2025,10.3390/ani15243541,https://pubmed.ncbi.nlm.nih.gov/41463826/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,41797481,&lt;i&gt;kdm4aa&lt;/i&gt; knockout disturbs early embryonic development in Zebrafish via downregulating &lt;i&gt;rbm46&lt;/i&gt;.,2026,10.1017/s0967199425100257,https://pubmed.ncbi.nlm.nih.gov/41797481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,40816057,"Toxic effects of trichlorfon on the hepatopancreas of Chinese mitten crab (Eriocheir sinensis): Tissue damage, oxidative stress, and Ferroptosis.",2025,10.1016/j.cbd.2025.101601,https://pubmed.ncbi.nlm.nih.gov/40816057/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,38884383,Destabilization of mRNAs enhances competence to initiate meiosis in mouse spermatogenic cells.,2024,10.1242/dev.202740,https://pubmed.ncbi.nlm.nih.gov/38884383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,36129965,The germ cell-specific RNA binding protein RBM46 is essential for spermatogonial differentiation in mice.,2022,10.1371/journal.pgen.1010416,https://pubmed.ncbi.nlm.nih.gov/36129965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,36726756,RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits.,2023,10.1093/procel/pwac040,https://pubmed.ncbi.nlm.nih.gov/36726756/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,36001654,RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis.,2022,10.1126/sciadv.abq2945,https://pubmed.ncbi.nlm.nih.gov/36001654/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,42249589,Novel variants in YTHDC2 cause non-obstructive azoospermia by disrupting the mitotic-to-meiotic transition in humans and mice.,2026,10.1093/humrep/deag086,https://pubmed.ncbi.nlm.nih.gov/42249589/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,38518724,Rbm46 inhibits reactive oxygen species in mouse embryonic stem cells through modulating BNIP3-mediated mitophagy.,2024,10.1016/j.bbrc.2024.149779,https://pubmed.ncbi.nlm.nih.gov/38518724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,38708190,Identification of RBM46 as a novel APOBEC1 cofactor for C-to-U RNA-editing activity.,2023,10.1016/j.jmb.2023.168333,https://pubmed.ncbi.nlm.nih.gov/38708190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,39295530,Short Chain Chlorinated Paraffins Impaired Spermatogenesis Process in Mice via Inhibiting α-KG/TET Enzyme Activity.,2024,10.1021/acs.est.4c05895,https://pubmed.ncbi.nlm.nih.gov/39295530/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,38156907,RNA-Binding Motif Protein RBM47 Promotes Invasiveness of Glioblastoma Through Activation of Epithelial-to-Mesenchymal Transition Program.,2023,10.1089/gtmb.2023.0368,https://pubmed.ncbi.nlm.nih.gov/38156907/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,33524105,"Rbm46, a novel germ cell-specific factor, modulates meiotic progression and spermatogenesis.",2021,10.1093/biolre/ioab016,https://pubmed.ncbi.nlm.nih.gov/33524105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,30362892,Expression analysis of a panel of cancer-testis antigens in bladder cancer.,2018,10.2217/pme-2018-0049,https://pubmed.ncbi.nlm.nih.gov/30362892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM46,ENSG00000151962,CTA,29635492,Gene-specific DNA methylation in newborns in response to folic acid supplementation during the second and third trimesters of pregnancy: epigenetic analysis from a randomized controlled trial.,2018,10.1093/ajcn/nqx069,https://pubmed.ncbi.nlm.nih.gov/29635492/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL2,ENSG00000170748,CTA,39356106,An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression.,2024,10.7554/elife.89705,https://pubmed.ncbi.nlm.nih.gov/39356106/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL2,ENSG00000170748,CTA,36102209,Cryptic splice site poisoning and meiotic arrest caused by a homozygous frameshift mutation in RBMXL2: A case report.,2022,10.1111/and.14595,https://pubmed.ncbi.nlm.nih.gov/36102209/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL2,ENSG00000170748,CTA,40813973,Single-variant genome-wide association study and regional heritability mapping of protein efficiency and performance traits in Large White pigs.,2025,10.1186/s12711-025-00993-z,https://pubmed.ncbi.nlm.nih.gov/40813973/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL2,ENSG00000170748,CTA,34927545,Cryptic splicing: common pathological mechanisms involved in male infertility and neuronal diseases.,2022,10.1080/15384101.2021.2015672,https://pubmed.ncbi.nlm.nih.gov/34927545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL2,ENSG00000170748,CTA,30674417,An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning.,2019,10.7554/elife.39304,https://pubmed.ncbi.nlm.nih.gov/30674417/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL2,ENSG00000170748,CTA,36939770,Systematic Genome-Wide Profiles Reveal Alternative Splicing Landscape and Implications of Splicing Regulator DExD-Box Helicase 21 in Aggressive Progression of Adrenocortical Carcinoma.,2021,10.1007/s43657-021-00026-x,https://pubmed.ncbi.nlm.nih.gov/36939770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL2,ENSG00000170748,CTA,18562473,Haploinsufficiency of the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse.,2008,10.1093/hmg/ddn179,https://pubmed.ncbi.nlm.nih.gov/18562473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL2,ENSG00000170748,CTA,15595951,"The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis.",2004,10.1111/j.1365-2605.2004.00496.x,https://pubmed.ncbi.nlm.nih.gov/15595951/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL2,ENSG00000170748,CTA,42826565,Prenatal exposure to Per- and polyfluoroalkyl substances and children's digit ratios based on Shanghai Minhang Birth Cohort: The role of DNA methylation in the placenta.,2026,10.1016/j.ecoenv.2026.120882,https://pubmed.ncbi.nlm.nih.gov/42826565/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL2,ENSG00000170748,CTA,10958650,An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene.,2000,10.1093/hmg/9.14.2117,https://pubmed.ncbi.nlm.nih.gov/10958650/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL3,ENSG00000175718,CTA,42204675,Multi-omic screening identifies RBMXL3 as a primate-specific RNA-binding protein and candidate regulator of RNA metabolism in human spermatogenesis.,2026,10.1186/s11658-026-00959-z,https://pubmed.ncbi.nlm.nih.gov/42204675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL3,ENSG00000175718,CTA,39932629,Genetic insights into non-obstructive azoospermia: Implications for diagnosis and TESE outcomes.,2025,10.1007/s10815-025-03409-5,https://pubmed.ncbi.nlm.nih.gov/39932629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL3,ENSG00000175718,CTA,41496282,Generation of an induced pluripotent stem cell line (SSMCi002-A) from a pediatric dilated cardiomyopathy patient carrying heterozygous mutation in the TTN gene.,2026,10.1016/j.scr.2025.103893,https://pubmed.ncbi.nlm.nih.gov/41496282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL3,ENSG00000175718,CTA,39267058,Whole exome sequencing analysis of 167 men with primary infertility.,2024,10.1186/s12920-024-02005-3,https://pubmed.ncbi.nlm.nih.gov/39267058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL3,ENSG00000175718,CTA,33719563,A primate-specific RNA-binding protein (RBMXL3) is involved in glucocorticoid regulation of human pulmonary surfactant protein B (SP-B) mRNA stability.,2021,10.1152/ajplung.00022.2020,https://pubmed.ncbi.nlm.nih.gov/33719563/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL3,ENSG00000175718,CTA,36017582,Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia.,2022,10.1111/andr.13269,https://pubmed.ncbi.nlm.nih.gov/36017582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL3,ENSG00000175718,CTA,33172452,Genomic profile of MYCN non-amplified neuroblastoma and potential for immunotherapeutic strategies in neuroblastoma.,2020,10.1186/s12920-020-00819-5,https://pubmed.ncbi.nlm.nih.gov/33172452/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL3,ENSG00000175718,CTA,30214282,Differences in clinical characteristics and mutational pattern between synchronous and metachronous colorectal liver metastases.,2018,10.2147/cmar.s161392,https://pubmed.ncbi.nlm.nih.gov/30214282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMXL3,ENSG00000175718,CTA,30305811,Additional Biomarkers beyond RAS That Impact the Efficacy of Cetuximab plus Chemotherapy in mCRC: A Retrospective Biomarker Analysis.,2018,10.1155/2018/5072987,https://pubmed.ncbi.nlm.nih.gov/30305811/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,39820129,Structural basis for assembly and function of the Salmonella flagellar MS-ring with three different symmetries.,2025,10.1038/s42003-025-07485-2,https://pubmed.ncbi.nlm.nih.gov/39820129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,35087486,Oligomerization of the FliF Domains Suggests a Coordinated Assembly of the Bacterial Flagellum MS Ring.,2021,10.3389/fmicb.2021.781960,https://pubmed.ncbi.nlm.nih.gov/35087486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,40151143,Breast cancer-derived exosomal miR-105-5p facilitates the transformation of NFs into CAFs through LATS2-NF-κB signaling.,2025,10.3724/abbs.2025017,https://pubmed.ncbi.nlm.nih.gov/40151143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,37205674,CryoEM structure of a post-assembly MS-ring reveals plasticity in stoichiometry and conformation.,2023,10.1371/journal.pone.0285343,https://pubmed.ncbi.nlm.nih.gov/37205674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,38369184,A fluorogenic substrate for the detection of lipid amidases in intact cells.,2024,10.1016/j.jlr.2024.100520,https://pubmed.ncbi.nlm.nih.gov/38369184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,36299451,ECE2 is a prognostic biomarker associated with m6A modification and involved in immune infiltration of lung adenocarcinoma.,2022,10.3389/fendo.2022.1013238,https://pubmed.ncbi.nlm.nih.gov/36299451/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,28115466,Loss of maternal Trim28 causes male-predominant early embryonic lethality.,2017,10.1101/gad.291195.116,https://pubmed.ncbi.nlm.nih.gov/28115466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,37371521,Long-Time Dynamics of Selected Molecular-Motor Components Using a Physics-Based Coarse-Grained Approach.,2023,10.3390/biom13060941,https://pubmed.ncbi.nlm.nih.gov/37371521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,35661078,Y Chromosome Genes May Play Roles in the Development of Neural Rosettes from Human Embryonic Stem Cells.,2022,10.1007/s12015-022-10392-2,https://pubmed.ncbi.nlm.nih.gov/35661078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,26162009,Isoform-Level Gene Expression Profiles of Human Y Chromosome Azoospermia Factor Genes and Their X Chromosome Paralogs in the Testicular Tissue of Non-Obstructive Azoospermia Patients.,2015,10.1021/acs.jproteome.5b00520,https://pubmed.ncbi.nlm.nih.gov/26162009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,26625006,Hypermethylation of genes in testicular embryonal carcinomas.,2016,10.1038/bjc.2015.408,https://pubmed.ncbi.nlm.nih.gov/26625006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,34793553,Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction.,2021,10.1371/journal.pone.0260283,https://pubmed.ncbi.nlm.nih.gov/34793553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,33314657,Structure-Based Drug Design of Phenazopyridine Derivatives as Inhibitors of Rev1 Interactions in Translesion Synthesis.,2021,10.1002/cmdc.202000893,https://pubmed.ncbi.nlm.nih.gov/33314657/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,20671934,Genetic dissection of the AZF regions of the human Y chromosome: thriller or filler for male (in)fertility?,2010,10.1155/2010/936569,https://pubmed.ncbi.nlm.nih.gov/20671934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,33327507,HCoV-NL63 and SARS-CoV-2 Share Recognized Epitopes by the Humoral Response in Sera of People Collected Pre- and during CoV-2 Pandemic.,2020,10.3390/microorganisms8121993,https://pubmed.ncbi.nlm.nih.gov/33327507/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,31056830,Characterization of a stress tolerance-defective mutant of Lactobacillus rhamnosus LRB.,2019,10.1111/omi.12262,https://pubmed.ncbi.nlm.nih.gov/31056830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,26041278,Combination with third-generation bisphosphonate (YM529) and interferon-alpha can inhibit the progression of established bone renal cell carcinoma.,2015,10.1111/cas.12711,https://pubmed.ncbi.nlm.nih.gov/26041278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,20443119,"The process of a Y-loss event in an XO/XO mammal, the Ryukyu spiny rat.",2010,10.1007/s00412-010-0275-8,https://pubmed.ncbi.nlm.nih.gov/20443119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,18709334,MMP-13 is over-expressed in renal cell carcinoma bone metastasis and is induced by TGF-beta1.,2008,10.1007/s10585-008-9202-2,https://pubmed.ncbi.nlm.nih.gov/18709334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,8978761,Microdeletions in interval 6 of the Y chromosome detected by STS-PCR in 6 of 33 patients with idiopathic oligo- or azoospermia.,1996,10.1159/000134174,https://pubmed.ncbi.nlm.nih.gov/8978761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,37129702,Backbone and ILV side-chain methyl NMR resonance assignments of human Rev7/Rev3-RBM1 and Rev7/Rev3-RBM2 complexes.,2023,10.1007/s12104-023-10128-4,https://pubmed.ncbi.nlm.nih.gov/37129702/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,17332933,"Blockade of the vascular endothelial growth factor-receptor 2 pathway inhibits the growth of human renal cell carcinoma, RBM1-IT4, in the kidney but not in the bone of nude mice.",2007,10.3892/ijo.30.4.937,https://pubmed.ncbi.nlm.nih.gov/17332933/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1A1,ENSG00000234414,CTA,8269511,A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis.,1993,10.1016/0092-8674(93)90616-x,https://pubmed.ncbi.nlm.nih.gov/8269511/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1B,ENSG00000242875,CTA,31171972,Genes located in Y-chromosomal regions important for male fertility show altered transcript levels in cryptorchidism and respond to curative hormone treatment.,2019,10.1186/s12610-019-0089-3,https://pubmed.ncbi.nlm.nih.gov/31171972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1E,ENSG00000242389,CTA,31171972,Genes located in Y-chromosomal regions important for male fertility show altered transcript levels in cryptorchidism and respond to curative hormone treatment.,2019,10.1186/s12610-019-0089-3,https://pubmed.ncbi.nlm.nih.gov/31171972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1F,ENSG00000169800,CTA,8269511,A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis.,1993,10.1016/0092-8674(93)90616-x,https://pubmed.ncbi.nlm.nih.gov/8269511/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1J,ENSG00000226941,CTA,38444014,Cytogenetics investigation in 151 Brazilian infertile male patients and genomic analysis in selected cases: experience of 14 years in a public genetic service.,2024,10.1186/s13104-024-06710-1,https://pubmed.ncbi.nlm.nih.gov/38444014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1J,ENSG00000226941,CTA,31171972,Genes located in Y-chromosomal regions important for male fertility show altered transcript levels in cryptorchidism and respond to curative hormone treatment.,2019,10.1186/s12610-019-0089-3,https://pubmed.ncbi.nlm.nih.gov/31171972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBMY1J,ENSG00000226941,CTA,8269511,A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis.,1993,10.1016/0092-8674(93)90616-x,https://pubmed.ncbi.nlm.nih.gov/8269511/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REDIC1,ENSG00000180116,CTA,37612290,A novel recombination protein C12ORF40/REDIC1 is required for meiotic crossover formation.,2023,10.1038/s41421-023-00577-5,https://pubmed.ncbi.nlm.nih.gov/37612290/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REDIC1,ENSG00000180116,CTA,37604834,Loss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression.,2023,10.1038/s41421-023-00580-w,https://pubmed.ncbi.nlm.nih.gov/37604834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REDIC1,ENSG00000180116,CTA,33193613,Identification of RNA Transcript Makers Associated With Prognosis of Kidney Renal Clear Cell Carcinoma by a Competing Endogenous RNA Network Analysis.,2020,10.3389/fgene.2020.540094,https://pubmed.ncbi.nlm.nih.gov/33193613/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,38697448,H3K27ac-induced RHOXF2 activates Wnt2/β-catenin pathway by binding to HOXC13 to aggravate the malignant progression of triple negative breast cancer.,2024,10.1016/j.cellsig.2024.111196,https://pubmed.ncbi.nlm.nih.gov/38697448/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,37761825,Mammal Reproductive Homeobox (Rhox) Genes: An Update of Their Involvement in Reproduction and Development.,2023,10.3390/genes14091685,https://pubmed.ncbi.nlm.nih.gov/37761825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,39090292,Oxaliplatin-induced upregulation of exosomal miR-424-3p derived from human bone marrow mesenchymal stem cells attenuates progression of gastric cancer cells.,2024,10.1038/s41598-024-68922-6,https://pubmed.ncbi.nlm.nih.gov/39090292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,38997129,Thg1 family 3'-5' RNA polymerases as tools for targeted RNA synthesis.,2024,10.1261/rna.080156.124,https://pubmed.ncbi.nlm.nih.gov/38997129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,40774528,Metal Ion Requirement for Catalysis by 3'-5' RNA Polymerases.,2025,10.1021/acs.biochem.5c00162,https://pubmed.ncbi.nlm.nih.gov/40774528/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,26784514,Identification of Novel HLA-A*24:02-Restricted Epitope Derived from a Homeobox Protein Expressed in Hematological Malignancies.,2016,10.1371/journal.pone.0146371,https://pubmed.ncbi.nlm.nih.gov/26784514/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,36107775,Human Thg1 displays tRNA-inducible GTPase activity.,2022,10.1093/nar/gkac768,https://pubmed.ncbi.nlm.nih.gov/36107775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,34083437,The Rhox gene cluster suppresses germline LINE1 transposition.,2021,10.1073/pnas.2024785118,https://pubmed.ncbi.nlm.nih.gov/34083437/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,32655042,Next-generation sequencing: toward an increase in the diagnostic yield in patients with apparently idiopathic spermatogenic failure.,2021,10.4103/aja.aja_25_20,https://pubmed.ncbi.nlm.nih.gov/32655042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,32636639,LOXL1-AS1 Contributes to Non-Small Cell Lung Cancer Progression by Regulating miR-3128/RHOXF2 Axis.,2020,10.2147/ott.s247900,https://pubmed.ncbi.nlm.nih.gov/32636639/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,26464818,Upregulation of RHOXF2 and ODF4 Expression in Breast Cancer Tissues.,2015,10.22074/cellj.2015.8,https://pubmed.ncbi.nlm.nih.gov/26464818/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,33790044,Fidelity of base-pair recognition by a 3'-5' polymerase: mechanism of the Saccharomyces cerevisiae tRNAHis guanylyltransferase.,2021,10.1261/rna.078686.121,https://pubmed.ncbi.nlm.nih.gov/33790044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,38132735,Isolation and Characterization of Novel Huperzine-Producing Endophytic Fungi from Lycopodiaceae Species.,2023,10.3390/jof9121134,https://pubmed.ncbi.nlm.nih.gov/38132735/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,28171660,The human RHOX gene cluster: target genes and functional analysis of gene variants in infertile men.,2016,10.1093/hmg/ddw313,https://pubmed.ncbi.nlm.nih.gov/28171660/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,23482336,The RHOX homeobox gene cluster is selectively expressed in human oocytes and male germ cells.,2013,10.1093/humrep/det043,https://pubmed.ncbi.nlm.nih.gov/23482336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,21988730,"Rapid evolution and copy number variation of primate RHOXF2, an X-linked homeobox gene involved in male reproduction and possibly brain function.",2011,10.1186/1471-2148-11-298,https://pubmed.ncbi.nlm.nih.gov/21988730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,25780578,"RHOXF2 gene, a new candidate gene for spermatogenesis failure.",2014,10.1186/2051-4190-24-3,https://pubmed.ncbi.nlm.nih.gov/25780578/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,33758037,Analysis of GTP addition in the reverse (3'-5') direction by human tRNAHis guanylyltransferase.,2021,10.1261/rna.078287.120,https://pubmed.ncbi.nlm.nih.gov/33758037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,30908619,5'-End sequencing in Saccharomyces cerevisiae offers new insights into 5'-ends of tRNAHis and snoRNAs.,2019,10.1002/1873-3468.13364,https://pubmed.ncbi.nlm.nih.gov/30908619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,31000629,Chemical footprinting and kinetic assays reveal dual functions for highly conserved eukaryotic tRNAHis guanylyltransferase residues.,2019,10.1074/jbc.ra119.007939,https://pubmed.ncbi.nlm.nih.gov/31000629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,25292049,Are so-called cancer-testis genes expressed only in testis?,2014,10.7314/apjcp.2014.15.18.7703,https://pubmed.ncbi.nlm.nih.gov/25292049/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,24944581,A genome scale overexpression screen to reveal drug activity in human cells.,2014,10.1186/gm549,https://pubmed.ncbi.nlm.nih.gov/24944581/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,21448135,Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence.,2011,10.1038/emboj.2011.95,https://pubmed.ncbi.nlm.nih.gov/21448135/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2,ENSG00000131721,CTA,12490318,"Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis.",2002,10.1016/s0378-1119(02)01087-9,https://pubmed.ncbi.nlm.nih.gov/12490318/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2B,ENSG00000203989,CTA,25780578,"RHOXF2 gene, a new candidate gene for spermatogenesis failure.",2014,10.1186/2051-4190-24-3,https://pubmed.ncbi.nlm.nih.gov/25780578/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF2B,ENSG00000203989,CTA,28171660,The human RHOX gene cluster: target genes and functional analysis of gene variants in infertile men.,2016,10.1093/hmg/ddw313,https://pubmed.ncbi.nlm.nih.gov/28171660/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMBP3,ENSG00000275793,CTA,35173218,Using publicly available transcriptomic data to identify mechanistic and diagnostic biomarkers in azoospermia and overall male infertility.,2022,10.1038/s41598-022-06476-1,https://pubmed.ncbi.nlm.nih.gov/35173218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMBP3,ENSG00000275793,CTA,35931115,Homeodomain-interacting protein kinase HIPK4 regulates phosphorylation of manchette protein RIMBP3 during spermiogenesis.,2022,10.1016/j.jbc.2022.102327,https://pubmed.ncbi.nlm.nih.gov/35931115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMBP3,ENSG00000275793,CTA,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMBP3,ENSG00000275793,CTA,29726656,[Aerobic exercise improves spermatogenesis of male rats: Results of iTRAQ-based proteomic analysis of the testis tissue].,2017,,https://pubmed.ncbi.nlm.nih.gov/29726656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMBP3,ENSG00000275793,CTA,28003339,LRGUK1 is part of a multiprotein complex required for manchette function and male fertility.,2017,10.1096/fj.201600909r,https://pubmed.ncbi.nlm.nih.gov/28003339/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMBP3,ENSG00000275793,CTA,36744215,Inhibitory activity of Enhydra fluctuans Lour. on calcium oxalate crystallisation through in silico and in vitro studies.,2022,10.3389/fphar.2022.982419,https://pubmed.ncbi.nlm.nih.gov/36744215/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMBP3C,ENSG00000183246,CTA,42286492,Diversity of molecular karyotypes of 234 pediatric patients with autism spectrum disorder in chromosomal microarray analysis.,2026,10.1186/s12888-026-08263-y,https://pubmed.ncbi.nlm.nih.gov/42286492/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMBP3C,ENSG00000183246,CTA,34402193,Key sunitinib-related biomarkers for renal cell carcinoma.,2021,10.1002/cam4.4206,https://pubmed.ncbi.nlm.nih.gov/34402193/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNASE12,ENSG00000258436,CTA,39476961,Epididymis-specific RNase A family genes regulate fertility and small RNA processing.,2024,10.1016/j.jbc.2024.107933,https://pubmed.ncbi.nlm.nih.gov/39476961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNASE13,ENSG00000206150,CTA,35211476,Anatomical Transcriptome Atlas of the Male Mouse Reproductive System During Aging.,2021,10.3389/fcell.2021.782824,https://pubmed.ncbi.nlm.nih.gov/35211476/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNASE13,ENSG00000206150,CTA,30927342,Nine genes abundantly expressed in the epididymis are not essential for male fecundity in mice.,2019,10.1111/andr.12621,https://pubmed.ncbi.nlm.nih.gov/30927342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNASE13,ENSG00000206150,CTA,34395233,A Novel Prognostic Model for Oral Squamous Cell Carcinoma: The Functions and Prognostic Values of RNA-Binding Proteins.,2021,10.3389/fonc.2021.592614,https://pubmed.ncbi.nlm.nih.gov/34395233/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNASE13,ENSG00000206150,CTA,28339009,"Identification of EGFLAM, SPATC1L and RNASE13 as novel susceptibility loci for aortic aneurysm in Japanese individuals by exome-wide association studies.",2017,10.3892/ijmm.2017.2927,https://pubmed.ncbi.nlm.nih.gov/28339009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNASE13,ENSG00000206150,CTA,24072271,Gene-based GWAS and biological pathway analysis of the resilience of executive functioning.,2014,10.1007/s11682-013-9259-7,https://pubmed.ncbi.nlm.nih.gov/24072271/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNASE13,ENSG00000206150,CTA,22711244,Genetic architecture of resilience of executive functioning.,2012,10.1007/s11682-012-9184-1,https://pubmed.ncbi.nlm.nih.gov/22711244/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF113B,ENSG00000139797,CTA,20889727,Primate and rodent specific intron gains and the origin of retrogenes with splice variants.,2011,10.1093/molbev/msq260,https://pubmed.ncbi.nlm.nih.gov/20889727/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF113B,ENSG00000139797,CTA,22045297,Novel mutation and three other sequence variants segregating with phenotype at keratoconus 13q32 susceptibility locus.,2012,10.1038/ejhg.2011.203,https://pubmed.ncbi.nlm.nih.gov/22045297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF133,ENSG00000188050,CTA,35831855,The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice.,2022,10.1186/s12915-022-01368-2,https://pubmed.ncbi.nlm.nih.gov/35831855/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF133,ENSG00000188050,CTA,37423931,Loss of PMFBP1 Disturbs Mouse Spermatogenesis by Downregulating HDAC3 Expression.,2023,10.1007/s10815-023-02874-0,https://pubmed.ncbi.nlm.nih.gov/37423931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF133,ENSG00000188050,CTA,39519104,Genome Sequencing Identifies 13 Novel Candidate Risk Genes for Autism Spectrum Disorder in a Qatari Cohort.,2024,10.3390/ijms252111551,https://pubmed.ncbi.nlm.nih.gov/39519104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF133,ENSG00000188050,CTA,40301718,Whole-genome sequencing reveals patterns of runs of homozygosity underlying genetic diversity and selection in domestic rabbits.,2025,10.1186/s12864-025-11616-8,https://pubmed.ncbi.nlm.nih.gov/40301718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF133,ENSG00000188050,CTA,33718161,"A Survival-Related Competitive Endogenous RNA Network of Prognostic lncRNAs, miRNAs, and mRNAs in Wilms Tumor.",2021,10.3389/fonc.2021.608433,https://pubmed.ncbi.nlm.nih.gov/33718161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF133,ENSG00000188050,CTA,32478068,Linking Phospho-Gonadotropin Regulated Testicular RNA Helicase (GRTH/DDX25) to Histone Ubiquitination and Acetylation Essential for Spermatid Development During Spermiogenesis.,2020,10.3389/fcell.2020.00310,https://pubmed.ncbi.nlm.nih.gov/32478068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF133,ENSG00000188050,CTA,18574499,Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase.,2008,10.1038/cr.2008.73,https://pubmed.ncbi.nlm.nih.gov/18574499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF148,ENSG00000235631,CTA,38190483,E3 ubiquitin ligase RNF148 functions as an oncogene in colorectal cancer by ubiquitination-mediated degradation of CHAC2.,2024,10.1093/carcin/bgae002,https://pubmed.ncbi.nlm.nih.gov/38190483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF148,ENSG00000235631,CTA,35831855,The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice.,2022,10.1186/s12915-022-01368-2,https://pubmed.ncbi.nlm.nih.gov/35831855/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF148,ENSG00000235631,CTA,24527571,[Identification and functional analysis of a testis-specific E3 ubiquitin ligase gene Rnf148 in mouse].,2014,,https://pubmed.ncbi.nlm.nih.gov/24527571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF148,ENSG00000235631,CTA,32106127,Whole-exome sequencing in a family with a monozygotic twin pair concordant for schizophrenia and a follow-up case-control study of identified de-novo variants.,2020,10.1097/ypg.0000000000000250,https://pubmed.ncbi.nlm.nih.gov/32106127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF148,ENSG00000235631,CTA,24089095,"Identification of a novel human testicular interstitial gene, RNF148, and its expression regulated by histone deacetylases.",2013,10.4238/2013.september.27.7,https://pubmed.ncbi.nlm.nih.gov/24089095/,annotation citations | normal,Discussed in explicit gene adjudication; see its review depth and limitations
RNF151,ENSG00000179580,CTA,41595482,New Candidate Genes for a Chicken Pectoralis Muscle Weight QTL Identified by a Hypothesis-Free Integrative Genetic Approach.,2026,10.3390/genes17010062,https://pubmed.ncbi.nlm.nih.gov/41595482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF151,ENSG00000179580,CTA,37423931,Loss of PMFBP1 Disturbs Mouse Spermatogenesis by Downregulating HDAC3 Expression.,2023,10.1007/s10815-023-02874-0,https://pubmed.ncbi.nlm.nih.gov/37423931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF151,ENSG00000179580,CTA,35831855,The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice.,2022,10.1186/s12915-022-01368-2,https://pubmed.ncbi.nlm.nih.gov/35831855/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF151,ENSG00000179580,CTA,31831960,Detection and analysis of stable and flexible genes towards a genome signature framework in cancer.,2019,10.6026/97320630015772,https://pubmed.ncbi.nlm.nih.gov/31831960/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF151,ENSG00000179580,CTA,35327988,Network Meta-Analysis of Chicken Microarray Data following Avian Influenza Challenge-A Comparison of Highly and Lowly Pathogenic Strains.,2022,10.3390/genes13030435,https://pubmed.ncbi.nlm.nih.gov/35327988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF151,ENSG00000179580,CTA,17577571,"RNF151, a testis-specific RING finger protein, interacts with dysbindin.",2007,10.1016/j.abb.2007.05.013,https://pubmed.ncbi.nlm.nih.gov/17577571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,42169188,Accelerated biological aging and underlying epigenetic modification mediated the association between obesity and asthma.,2026,10.1186/s13148-026-02145-6,https://pubmed.ncbi.nlm.nih.gov/42169188/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,40629240,"The Complicity of DAAM1, PTMA, RSPH6A, and Steroidogenic Genes in the Fertility of Male Rats Exposed to Cadmium During Gestation and Lactation: Attenuation by PREOG.",2025,10.1007/s43032-025-01902-x,https://pubmed.ncbi.nlm.nih.gov/40629240/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,40429724,"Impact of Type 1 Diabetes on Testicular Microtubule Dynamics, Sperm Physiology, and Male Reproductive Health in Rat.",2025,10.3390/ijms26104579,https://pubmed.ncbi.nlm.nih.gov/40429724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,37795044,Expression of RSPH6A in the first wave of rat spermatogenesis and oxidative stress conditions: Attenuation by melatonin.,2023,10.1002/rmb2.12542,https://pubmed.ncbi.nlm.nih.gov/37795044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,39849482,IQUB mutation induces radial spoke 1 deficiency causing asthenozoospermia with normal sperm morphology in humans and mice.,2025,10.1186/s12964-025-02043-z,https://pubmed.ncbi.nlm.nih.gov/39849482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,38884051,Unraveling the Genetic Basis of Combined Deafness and Male Infertility Phenotypes through High-Throughput Sequencing in a Unique Cohort from South India.,2024,10.1002/ggn2.202300206,https://pubmed.ncbi.nlm.nih.gov/38884051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,38891632,Integrated miRNA and mRNA Sequencing Reveals the Sterility Mechanism in Hybrid Yellow Catfish Resulting from Pelteobagrus fulvidraco (♀) × Pelteobagrus vachelli (♂).,2024,10.3390/ani14111586,https://pubmed.ncbi.nlm.nih.gov/38891632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,38061432,Transcriptome and proteome analyses reveal the mechanisms involved in polystyrene nanoplastics disrupt spermatogenesis in mice.,2024,10.1016/j.envpol.2023.123086,https://pubmed.ncbi.nlm.nih.gov/38061432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,30239614,Sperm capacitation is associated with phosphorylation of the testis-specific radial spoke protein Rsph6a†.,2019,10.1093/biolre/ioy202,https://pubmed.ncbi.nlm.nih.gov/30239614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,35886074,Further Insights on RNA Expression and Sperm Motility.,2022,10.3390/genes13071291,https://pubmed.ncbi.nlm.nih.gov/35886074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,30185526,RSPH6A is required for sperm flagellum formation and male fertility in mice.,2018,10.1242/jcs.221648,https://pubmed.ncbi.nlm.nih.gov/30185526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,32901808,CRISPR/CAS9-mediated amino acid substitution reveals phosphorylation residues of RSPH6A are not essential for male fertility in mice†.,2020,10.1093/biolre/ioaa161,https://pubmed.ncbi.nlm.nih.gov/32901808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,35563519,New Insight on the In Vitro Effects of Melatonin in Preserving Human Sperm Quality.,2022,10.3390/ijms23095128,https://pubmed.ncbi.nlm.nih.gov/35563519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,31840338,Study of expression of genes potentially responsible for reduced fitness in patients with myotonic dystrophy type 1 and identification of new biomarkers of testicular function.,2020,10.1002/mrd.23307,https://pubmed.ncbi.nlm.nih.gov/31840338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,26756355,Epigenetics of the myotonic dystrophy-associated DMPK gene neighborhood.,2016,10.2217/epi.15.104,https://pubmed.ncbi.nlm.nih.gov/26756355/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,34871179,Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM.,2021,10.1073/pnas.2021180118,https://pubmed.ncbi.nlm.nih.gov/34871179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,35937804,NAT10 Maintains OGA mRNA Stability Through ac4C Modification in Regulating Oocyte Maturation.,2022,10.3389/fendo.2022.907286,https://pubmed.ncbi.nlm.nih.gov/35937804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,29391579,"A missense mutation in TRAPPC6A leads to build-up of the protein, in patients with a neurodevelopmental syndrome and dysmorphic features.",2018,10.1038/s41598-018-20658-w,https://pubmed.ncbi.nlm.nih.gov/29391579/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH6A,ENSG00000104941,CTA,11237735,"A mammalian radial spokehead-like gene, RSHL1, at the myotonic dystrophy-1 locus.",2001,10.1006/bbrc.2001.4465,https://pubmed.ncbi.nlm.nih.gov/11237735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42540535,Dietary and Endogenous Advanced Glycation End Product and Breast Carcinogenesis: A Challenging Lack of Association in a Rigorous Case-Control Study.,2026,10.1155/jnme/6687630,https://pubmed.ncbi.nlm.nih.gov/42540535/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,41486374,SAGE: Spatially Aware Gene Selection and Dual-View Embedding Fusion for Domain Identification in Spatial Transcriptomics.,2026,10.1002/advs.202520333,https://pubmed.ncbi.nlm.nih.gov/41486374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42344858,Introducing the SAGE study: a multimodal protocol for testing a GABAergic mechanism of age-related episodic memory impairment across the sexes.,2026,10.1136/bmjno-2026-001546,https://pubmed.ncbi.nlm.nih.gov/42344858/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42687357,Feasibility of Spin- and Gradient-Echo Dynamic Susceptibility Contrast MRI for Microvascular Characterization at 7 Tesla.,2026,10.1002/nbm.70380,https://pubmed.ncbi.nlm.nih.gov/42687357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42450151,Multisystemic Consequences of Brain-Derived Neurotrophic Factor (BDNF) Haploinsufficiency in the SD-BDNFtm1sage Rat Model.,2026,10.3390/ijms27135881,https://pubmed.ncbi.nlm.nih.gov/42450151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42447034,In vitro mouse preantral follicle development in 2D and suspension culture: α-MEM vs SAGE 1-step.,2026,10.1530/raf-25-0158,https://pubmed.ncbi.nlm.nih.gov/42447034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42163745,Multi-Target Neuroprotection of Salvia officinalis Aqueous Extract in a Scopolamine-Induced Model of Alzheimer's Disease: Comparative Efficacy Versus Donepezil.,2026,10.2174/0113816128429239260312074215,https://pubmed.ncbi.nlm.nih.gov/42163745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42780892,"Effect of Pulsed Electric Field (PEF) Pretreatments on the Phytochemical Composition, Antioxidant, and Antimicrobial Properties of Sage Extracts.",2026,10.1155/ijfo/3565398,https://pubmed.ncbi.nlm.nih.gov/42780892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42338609,Restorative potential of laser-synthesized silver nanoparticles with &lt;i&gt;Salvia officinalis&lt;/i&gt; for periodontal disease treatment: an in vitro study.,2026,10.3762/bjnano.17.55,https://pubmed.ncbi.nlm.nih.gov/42338609/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42750971,Fangchinoline (2021-2026): A Multitarget Bisbenzylisoquinoline Alkaloid With Emerging Anti-Infective Potential.,2026,10.1155/jotm/5617306,https://pubmed.ncbi.nlm.nih.gov/42750971/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42688574,Systematic review of unveiling the potential of AI using machine learning and deep learning methods in neurodegenerative diseases.,2026,10.7717/peerj-cs.3860,https://pubmed.ncbi.nlm.nih.gov/42688574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,40415416,The progression of multiple myeloma is regulated by LILRB1 via the GATA2-SAGE1 pathway.,2025,10.1111/bjh.20144,https://pubmed.ncbi.nlm.nih.gov/40415416/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,39951051,Symptoms Associated With Gadolinium Exposure: Different Patterns and Rates Between Linear and Macrocyclic Gadolinium-Based Contrast Agents.,2025,10.1097/rli.0000000000001160,https://pubmed.ncbi.nlm.nih.gov/39951051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,41177950,"Spin and Gradient Multiple Overlapping-Echo Detachment Imaging (SAGE-MOLED): Highly Efficient T&lt;sub&gt;2&lt;/sub&gt;, $$ {T}_2^{\ast } $$ , and M&lt;sub&gt;0&lt;/sub&gt; Mapping for Simultaneous Perfusion and Permeability Measurements.",2026,10.1002/mrm.70165,https://pubmed.ncbi.nlm.nih.gov/41177950/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42173900,Neofunctionalization underlies the evolutionary origin of sclareol biosynthesis in the mint family.,2026,10.1038/s41467-026-73637-5,https://pubmed.ncbi.nlm.nih.gov/42173900/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42214507,Sage (Salvia spp.) as a multi-target resource for healthy aging: Current evidence and perspectives.,2026,10.1016/j.mad.2026.112204,https://pubmed.ncbi.nlm.nih.gov/42214507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,41155268,Regulatory Mechanisms and Functional Roles of Readthrough Transcripts in Tumorigenesis.,2025,10.3390/ijms26209975,https://pubmed.ncbi.nlm.nih.gov/41155268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42588496,"Evaluating the Therapeutic Potential of Common Sage (&lt;i&gt;Salvia officinalis&lt;/i&gt; L.): Antioxidant Capacity, Cytotoxicity and Dose-Dependent Effects on Gastric Smooth Muscle Viability and Function.",2026,10.3390/molecules31152647,https://pubmed.ncbi.nlm.nih.gov/42588496/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42903865,Relative Brain Perfusion Differences and Cognitive Improvement During Multimodal Management in a Patient With Progressive Cognitive Symptoms: A Case Report.,2026,10.7759/cureus.116590,https://pubmed.ncbi.nlm.nih.gov/42903865/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,41645874,NRN1 as a therapeutic target for Alzheimer's disease.,2026,10.1002/alz.71149,https://pubmed.ncbi.nlm.nih.gov/41645874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42864943,"Intelligent thermoregulation strategy versus routine thermal management on myocardial injury after noncardiac surgery during gastrointestinal tumor resection in elderly patients (SAGE): a multicenter, parallel-group, superiority trial.",2026,10.1080/07853890.2026.2732429,https://pubmed.ncbi.nlm.nih.gov/42864943/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42374300,A systematic review of the determinants of vaccine hesitancy in the UK: Implications for future TB vaccine adoption.,2026,10.1186/s12889-026-28299-9,https://pubmed.ncbi.nlm.nih.gov/42374300/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42897533,Protocol for a parallel-group superiority randomized controlled trial comparing Sage- a couple psychotherapy- to supportive individual psychotherapy for borderline personality disorder.,2026,10.1186/s12888-026-08374-6,https://pubmed.ncbi.nlm.nih.gov/42897533/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42334562,Factors associated with vaccination intentions and uptake among pregnant women in the UK: A scoping review.,2026,10.1080/21645515.2026.2687220,https://pubmed.ncbi.nlm.nih.gov/42334562/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,41770744,Adult dengue vaccination in a low transmission setting: A modelling study in Singapore.,2026,10.1371/journal.pntd.0014062,https://pubmed.ncbi.nlm.nih.gov/41770744/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42506614,"Vaccine Hesitancy Among Caregivers in China: Associations of Misinterpreted AEFI, Compensation Awareness, and Institutional Trust.",2026,10.3390/vaccines14070577,https://pubmed.ncbi.nlm.nih.gov/42506614/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42566377,SAGE: Subject-Adaptive Graph-Based Modeling With Decision-Level Calibration for Stress and Cognitive Workload Monitoring.,2026,10.1109/jbhi.2026.3722060,https://pubmed.ncbi.nlm.nih.gov/42566377/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,41548668,An on-site cascading vaccine breaks tumor immune evasion and elicits systemic immunity.,2026,10.1016/j.jconrel.2026.114641,https://pubmed.ncbi.nlm.nih.gov/41548668/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42192632,SAGE (safer analgesia): a protocol for a pragmatic cluster randomised controlled trial to reduce the use of high-risk medicines in people with chronic back and/or neck pain.,2026,10.1136/bmjopen-2026-119354,https://pubmed.ncbi.nlm.nih.gov/42192632/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42022632,Mpox (Monkeypox) in Pregnancy Updates.,2026,10.1002/hsr2.72111,https://pubmed.ncbi.nlm.nih.gov/42022632/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42717765,Local large language model-guided optimization for prostate radiotherapy planning.,2026,10.1002/mp.70654,https://pubmed.ncbi.nlm.nih.gov/42717765/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,39772062,"The Strategic Advisory Group of Experts (SAGE) on Immunization-Past, Present and Future.",2024,10.3390/vaccines12121402,https://pubmed.ncbi.nlm.nih.gov/39772062/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,41295482,Adoption of Focus Groups in Designing Interventions to Address Vaccine Hesitancy Among Adolescents and Their Parents: A Systematic Review.,2025,10.3390/vaccines13111108,https://pubmed.ncbi.nlm.nih.gov/41295482/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,42172692,"Willingness to receive Ebola vaccines among pregnant and lactating women in Kampala, Uganda: insights from a post-outbreak cross-sectional study.",2026,10.1016/j.vaccine.2026.128737,https://pubmed.ncbi.nlm.nih.gov/42172692/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAGE1,ENSG00000181433,CTA,10919659,Identification on a human sarcoma of two new genes with tumor-specific expression.,2000,,https://pubmed.ncbi.nlm.nih.gov/10919659/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCP2D1,ENSG00000132631,CTA,35627192,Cancer-Testis Gene Biomarkers Discovered in Colon Cancer Patients.,2022,10.3390/genes13050807,https://pubmed.ncbi.nlm.nih.gov/35627192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCP2D1,ENSG00000132631,CTA,36355490,The Expression Patterns of Human Cancer-Testis Genes Are Induced through Epigenetic Drugs in Colon Cancer Cells.,2022,10.3390/ph15111319,https://pubmed.ncbi.nlm.nih.gov/36355490/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCP2D1,ENSG00000132631,CTA,35571188,Genome-Wide Identification of Associations of Circulating Molecules With Spontaneous Coronary Artery Dissection and Aortic Aneurysm and Dissection.,2022,10.3389/fcvm.2022.874912,https://pubmed.ncbi.nlm.nih.gov/35571188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCP2D1,ENSG00000132631,CTA,32243084,Identification and quantification of coding and long non-coding RNAs in stallion spermatozoa separated by density.,2020,10.1111/andr.12791,https://pubmed.ncbi.nlm.nih.gov/32243084/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCP2D1,ENSG00000132631,CTA,26943675,Demographically-Based Evaluation of Genomic Regions under Selection in Domestic Dogs.,2016,10.1371/journal.pgen.1005851,https://pubmed.ncbi.nlm.nih.gov/26943675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCP2D1,ENSG00000132631,CTA,19574904,Exclusion of positional candidate gene coding region mutations in the common posterior polymorphous corneal dystrophy 1 candidate gene interval.,2009,10.1097/ico.0b013e31819672fb,https://pubmed.ncbi.nlm.nih.gov/19574904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEL1L2,ENSG00000101251,CTA,41254487,Genome-wide association study identifies genetic variants associated with single-parity reproductive loss in three commercial pig breeds.,2025,10.1186/s12864-025-12255-9,https://pubmed.ncbi.nlm.nih.gov/41254487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEL1L2,ENSG00000101251,CTA,37049393,"Crosstalk between Gut Microbiota and Epigenetic Markers in Obesity Development: Relationship between Ruminococcus, BMI, and MACROD2/SEL1L2 Methylation.",2023,10.3390/nu15071550,https://pubmed.ncbi.nlm.nih.gov/37049393/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEL1L2,ENSG00000101251,CTA,32530565,A recurrent PJA1 variant in trigonocephaly and neurodevelopmental disorders.,2020,10.1002/acn3.51093,https://pubmed.ncbi.nlm.nih.gov/32530565/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,39982757,SEPT14 complexes maintain sperm morphogenesis and function.,2025,10.1096/fj.202402135r,https://pubmed.ncbi.nlm.nih.gov/39982757/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,38911794,Transcriptome Study of rd1Mouse Brain and Association with Parkinson's Disease.,2024,10.1021/acsomega.3c09938,https://pubmed.ncbi.nlm.nih.gov/38911794/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,41699652,Boundary-associated propagation of a processed pseudogene dissects pre-existing limitations of genome annotation in the T2T era.,2026,10.1186/s13100-026-00394-z,https://pubmed.ncbi.nlm.nih.gov/41699652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,42089945,Nationwide genomic data analysis of central nervous system tumors in Japan based on C-CAT database.,2026,10.1007/s10147-026-03031-0,https://pubmed.ncbi.nlm.nih.gov/42089945/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,36295569,Localization Patterns of RAB3C Are Associated with Murine and Human Sperm Formation.,2022,10.3390/medicina58101408,https://pubmed.ncbi.nlm.nih.gov/36295569/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,33791027,"Septin14, a gene specifically expressed in the testis and seminal vesicle of the Banna mini-pig inbred line (BMI).",2021,10.1590/1984-3143-ar2020-0521,https://pubmed.ncbi.nlm.nih.gov/33791027/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,40794131,"Tumor location, genomic alterations, and radiomic features as predictors of survival in glioblastoma: a Multi-Modal analysis.",2025,10.1007/s00234-025-03742-7,https://pubmed.ncbi.nlm.nih.gov/40794131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,35571367,Effects of Septin-14 Gene Deletion on Adult Cognitive/Emotional Behavior.,2022,10.3389/fnmol.2022.880858,https://pubmed.ncbi.nlm.nih.gov/35571367/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,37554188,A novel acquired EGFR-SEPT14 fusion confers differential drug resistance to EGFR inhibitors in lung adenocarcinoma.,2023,10.1016/j.gendis.2023.02.019,https://pubmed.ncbi.nlm.nih.gov/37554188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,33228246,ACTN4 Mediates SEPT14 Mutation-Induced Sperm Head Defects.,2020,10.3390/biomedicines8110518,https://pubmed.ncbi.nlm.nih.gov/33228246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,37712436,X-ray structure of the metastable SEPT14-SEPT7 coiled coil reveals a hendecad region crucial for heterodimerization.,2023,10.1107/s2059798323006514,https://pubmed.ncbi.nlm.nih.gov/37712436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,36002559,In silico validation of RNA-Seq results can identify gene fusions with oncogenic potential in glioblastoma.,2022,10.1038/s41598-022-18608-8,https://pubmed.ncbi.nlm.nih.gov/36002559/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,33969073,Detection of EGFR-SEPT14 fusion in cell-free DNA of a patient with advanced gastric cancer: A case report.,2021,10.12998/wjcc.v9.i12.2884,https://pubmed.ncbi.nlm.nih.gov/33969073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,31450874,SEPT14 Mutations and Teratozoospermia: Genetic Effects on Sperm Head Morphology and DNA Integrity.,2019,10.3390/jcm8091297,https://pubmed.ncbi.nlm.nih.gov/31450874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,38986051,Phase II Trial of Afatinib in Patients With &lt;i&gt;EGFR&lt;/i&gt;-Mutated Solid Tumors Excluding Lung Cancer: Results From NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol A.,2024,10.1200/po.23.00725,https://pubmed.ncbi.nlm.nih.gov/38986051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,31502214,Concurrent Identification of Novel EGFR-SEPT14 Fusion and ETV6-RET Fusion in Secretory Carcinoma of the Salivary Gland.,2020,10.1007/s12105-019-01074-6,https://pubmed.ncbi.nlm.nih.gov/31502214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,32162810,A Rare EGFR-SEPT14 Fusion in a Patient with Colorectal Adenocarcinoma Responding to Erlotinib.,2020,10.1634/theoncologist.2019-0405,https://pubmed.ncbi.nlm.nih.gov/32162810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,37033211,Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses.,2023,10.3389/fendo.2023.1143067,https://pubmed.ncbi.nlm.nih.gov/37033211/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,24799881,Comparative expression analysis of Septin 14 in testes of infertile men with normal spermatogenesis and spermatogenic failure.,2014,,https://pubmed.ncbi.nlm.nih.gov/24799881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,36160735,Profiling of gene fusion involving targetable genes in Chinese gastric cancer.,2022,10.4251/wjgo.v14.i8.1528,https://pubmed.ncbi.nlm.nih.gov/36160735/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,27882315,Septin Mutations in Human Cancers.,2016,10.3389/fcell.2016.00122,https://pubmed.ncbi.nlm.nih.gov/27882315/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,32249155,Expression and localization of Septin 14 gene and protein in infertile men testis.,2020,10.1016/j.repbio.2020.03.007,https://pubmed.ncbi.nlm.nih.gov/32249155/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN14,ENSG00000154997,CTA,17922164,"Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin.",2007,10.1007/s00335-007-9065-x,https://pubmed.ncbi.nlm.nih.gov/17922164/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLECL1,ENSG00000179213,CTA,32647856,CD33 and SIGLECL1 Immunoglobulin Superfamily Involved in Dementia.,2020,10.1093/jnen/nlaa055,https://pubmed.ncbi.nlm.nih.gov/32647856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLECL1,ENSG00000179213,CTA,11943481,Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes.,2002,10.1016/s0378-1119(02)00432-8,https://pubmed.ncbi.nlm.nih.gov/11943481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A14,ENSG00000144671,CTA,33882315,SLC22A14 is a mitochondrial riboflavin transporter required for sperm oxidative phosphorylation and male fertility.,2021,10.1016/j.celrep.2021.109025,https://pubmed.ncbi.nlm.nih.gov/33882315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A14,ENSG00000144671,CTA,34704967,Dysregulation of intracellular pH is a cause of impaired capacitation in Slc22a14-deficient mice.,2021,10.1530/rep-21-0135,https://pubmed.ncbi.nlm.nih.gov/34704967/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A14,ENSG00000144671,CTA,34921098,Emerging Roles of the Human Solute Carrier 22 Family.,2021,10.1124/dmd.121.000702,https://pubmed.ncbi.nlm.nih.gov/34921098/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A14,ENSG00000144671,CTA,27811987,A critical role of solute carrier 22a14 in sperm motility and male fertility in mice.,2016,10.1038/srep36468,https://pubmed.ncbi.nlm.nih.gov/27811987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A14,ENSG00000144671,CTA,39794985,Integrating Genomic Selection and a Genome-Wide Association Study to Improve Days Open in Thai Dairy Holstein Cattle: A Comprehensive Genetic Analysis.,2024,10.3390/ani15010043,https://pubmed.ncbi.nlm.nih.gov/39794985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A14,ENSG00000144671,CTA,34948211,SLC22 Transporters in the Fly Renal System Regulate Response to Oxidative Stress In Vivo.,2021,10.3390/ijms222413407,https://pubmed.ncbi.nlm.nih.gov/34948211/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A14,ENSG00000144671,CTA,38396873,Genetic Biomarkers of Sorafenib Response in Patients with Hepatocellular Carcinoma.,2024,10.3390/ijms25042197,https://pubmed.ncbi.nlm.nih.gov/38396873/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A14,ENSG00000144671,CTA,29726644,[Expressions of SLC22A14 and SPAG6 proteins in the ejaculated sperm of idiopathic asthenozoospermia patients.],2017,,https://pubmed.ncbi.nlm.nih.gov/29726644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A14,ENSG00000144671,CTA,27519738,"Phylogenetic, syntenic, and tissue expression analysis of slc22 genes in zebrafish (Danio rerio).",2016,10.1186/s12864-016-2981-y,https://pubmed.ncbi.nlm.nih.gov/27519738/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A14,ENSG00000144671,CTA,30817750,Reproducibility of pharmacogenetics findings for paclitaxel in a heterogeneous population of patients with lung cancer.,2019,10.1371/journal.pone.0212097,https://pubmed.ncbi.nlm.nih.gov/30817750/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A14,ENSG00000144671,CTA,10072596,"Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters.",1998,10.1159/000015197,https://pubmed.ncbi.nlm.nih.gov/10072596/,annotation citations | normal,Discussed in explicit gene adjudication; see its review depth and limitations
SLC22A14,ENSG00000144671,CTA,29027019,Explorative results from multistep screening for potential genetic risk loci of Alzheimer's disease in the longitudinal VITA study cohort.,2018,10.1007/s00702-017-1796-6,https://pubmed.ncbi.nlm.nih.gov/29027019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A14,ENSG00000144671,CTA,16131712,"Effect of splice-site polymorphisms of the TMPRSS4, NPHP4 and ORCTL4 genes on their mRNA expression.",2005,10.1007/bf02715838,https://pubmed.ncbi.nlm.nih.gov/16131712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A14,ENSG00000144671,CTA,19002527,Alopecia and male infertility in oligotriche mutant mice are caused by a deletion on distal chromosome 9.,2008,10.1007/s00335-008-9150-9,https://pubmed.ncbi.nlm.nih.gov/19002527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35G6,ENSG00000259224,CTA,34635181,Deciphering genes associated with diffuse large B-cell lymphoma with lymphomatous effusions: A mutational accumulation scoring approach.,2021,10.1186/s40364-021-00330-8,https://pubmed.ncbi.nlm.nih.gov/34635181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35G6,ENSG00000259224,CTA,32121467,Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity.,2020,10.3390/genes11030268,https://pubmed.ncbi.nlm.nih.gov/32121467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35G6,ENSG00000259224,CTA,17101974,Emergence of primate genes by retrotransposon-mediated sequence transduction.,2006,10.1073/pnas.0603224103,https://pubmed.ncbi.nlm.nih.gov/17101974/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC36A3,ENSG00000186334,CTA,37630739,The Role of Proton-Coupled Amino Acid Transporter 2 (SLC36A2) in Cold-Induced Thermogenesis of Mice.,2023,10.3390/nu15163552,https://pubmed.ncbi.nlm.nih.gov/37630739/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC36A3,ENSG00000186334,CTA,40912149,Perturbation of the ovine placental transcriptome occurs at sub-therapeutic exposures to antenatal steroid therapy.,2025,10.1016/j.placenta.2025.09.002,https://pubmed.ncbi.nlm.nih.gov/40912149/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC36A3,ENSG00000186334,CTA,39826593,Accelerated MR cell size imaging through parallel acquisition technique (PAT) and simultaneous multi-slice (SMS) with local principal component analysis (LPCA) enhancement.,2025,10.1016/j.mri.2025.110327,https://pubmed.ncbi.nlm.nih.gov/39826593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC36A3,ENSG00000186334,CTA,38635962,Arabidopsis class A S-acyl transferases modify the pollen receptors LIP1 and PRK1 to regulate pollen tube guidance.,2024,10.1093/plcell/koae109,https://pubmed.ncbi.nlm.nih.gov/38635962/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC36A3,ENSG00000186334,CTA,35126298,Emotional Recognition in Patients With Mesial Temporal Epilepsy Associated With Enlarged Amygdala.,2021,10.3389/fneur.2021.803787,https://pubmed.ncbi.nlm.nih.gov/35126298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC36A3,ENSG00000186334,CTA,27297468,Coevolution between Stop Codon Usage and Release Factors in Bacterial Species.,2016,10.1093/molbev/msw107,https://pubmed.ncbi.nlm.nih.gov/27297468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC36A3,ENSG00000186334,CTA,23770835,Retromer subunits VPS35A and VPS29 mediate prevacuolar compartment (PVC) function in Arabidopsis.,2013,10.1093/mp/sst044,https://pubmed.ncbi.nlm.nih.gov/23770835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC36A3,ENSG00000186334,CTA,21501141,The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport.,2011,10.1111/j.1476-5381.2011.01438.x,https://pubmed.ncbi.nlm.nih.gov/21501141/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC36A3,ENSG00000186334,CTA,12809675,A cluster of proton/amino acid transporter genes in the human and mouse genomes.,2003,10.1016/s0888-7543(03)00099-5,https://pubmed.ncbi.nlm.nih.gov/12809675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC36A3,ENSG00000186334,CTA,19480705,Transcriptomic analysis of tomato carpel development reveals alterations in ethylene and gibberellin synthesis during pat3/pat4 parthenocarpic fruit set.,2009,10.1186/1471-2229-9-67,https://pubmed.ncbi.nlm.nih.gov/19480705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC36A3,ENSG00000186334,CTA,15058382,Organization and expression of the SLC36 cluster of amino acid transporter genes.,2004,10.1007/s00335-003-2319-3,https://pubmed.ncbi.nlm.nih.gov/15058382/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC36A3,ENSG00000186334,CTA,11726703,The phytochrome A specific signaling component PAT3 is a positive regulator of Arabidopsis photomorphogenesis.,2001,10.1093/pcp/pce177,https://pubmed.ncbi.nlm.nih.gov/11726703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC36A3,ENSG00000186334,CTA,18802473,Missense mutation in exon 2 of SLC36A1 responsible for champagne dilution in horses.,2008,10.1371/journal.pgen.1000195,https://pubmed.ncbi.nlm.nih.gov/18802473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC36A3,ENSG00000186334,CTA,18384693,"Development of patatin knockdown potato tubers using RNA interference (RNAi) technology, for the production of human-therapeutic glycoproteins.",2008,10.1186/1472-6750-8-36,https://pubmed.ncbi.nlm.nih.gov/18384693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC36A3,ENSG00000186334,CTA,15469493,The nuclear localization signal and the C-terminal region of FHY1 are required for transmission of phytochrome A signals.,2004,10.1111/j.1365-313x.2004.02212.x,https://pubmed.ncbi.nlm.nih.gov/15469493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC36A3,ENSG00000186334,CTA,15291811,Substrate specificity and transport mode of the proton-dependent amino acid transporter mPAT2.,2004,10.1111/j.1432-1033.2004.04268.x,https://pubmed.ncbi.nlm.nih.gov/15291811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC36A3,ENSG00000186334,CTA,36441446,Evaluating an under-mattress sleep monitor compared to a peripheral arterial tonometry home sleep apnea test device in the diagnosis of obstructive sleep apnea.,2023,10.1007/s11325-022-02751-7,https://pubmed.ncbi.nlm.nih.gov/36441446/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO6A1,ENSG00000205359,CTA,40148036,"Organic anion transporting polypeptides: Pharmacology, toxicology, structure, and transport mechanisms.",2025,10.1016/j.pharmr.2024.100023,https://pubmed.ncbi.nlm.nih.gov/40148036/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO6A1,ENSG00000205359,CTA,41503337,Unveiling Novel Genetic Mutations and Prognostic Indicators in Breast Carcinoma: An Analysis of The Cancer Genome Atlas (TCGA) Data.,2025,10.7759/cureus.98637,https://pubmed.ncbi.nlm.nih.gov/41503337/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO6A1,ENSG00000205359,CTA,35307651,Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.,2022,10.1124/dmd.121.000748,https://pubmed.ncbi.nlm.nih.gov/35307651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO6A1,ENSG00000205359,CTA,26861727,"Analysis of association between common variants in the SLCO6A1 gene with schizophrenia, bipolar disorder and major depressive disorder in the Han Chinese population.",2016,10.3109/15622975.2015.1126676,https://pubmed.ncbi.nlm.nih.gov/26861727/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO6A1,ENSG00000205359,CTA,23431456,Tumor-specific expression of organic anion-transporting polypeptides: transporters as novel targets for cancer therapy.,2013,10.1155/2013/863539,https://pubmed.ncbi.nlm.nih.gov/23431456/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO6A1,ENSG00000205359,CTA,25301452,Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy.,2015,10.1016/j.canlet.2014.09.025,https://pubmed.ncbi.nlm.nih.gov/25301452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO6A1,ENSG00000205359,CTA,15546177,Identification of the gonad-specific anion transporter SLCO6A1 as a cancer/testis (CT) antigen expressed in human lung cancer.,2004,,https://pubmed.ncbi.nlm.nih.gov/15546177/,annotation citations | normal | therapy,Discussed in explicit gene adjudication; see its review depth and limitations
SLCO6A1,ENSG00000205359,CTA,18426187,Cancer-testis (CT) antigen expression in medulloblastoma.,2008,,https://pubmed.ncbi.nlm.nih.gov/18426187/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO6A1,ENSG00000205359,CTA,21395542,Organic anion transporting polypeptides (OATPs): regulation of expression and function.,2011,10.2174/138920011795016863,https://pubmed.ncbi.nlm.nih.gov/21395542/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO6A1,ENSG00000205359,CTA,23987090,Organic anion-transporting polypeptides: a novel approach for cancer therapy.,2014,10.3109/1061186x.2013.832767,https://pubmed.ncbi.nlm.nih.gov/23987090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO6A1,ENSG00000205359,CTA,28489853,Novel genes involved in severe early-onset obesity revealed by rare copy number and sequence variants.,2017,10.1371/journal.pgen.1006657,https://pubmed.ncbi.nlm.nih.gov/28489853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO6A1,ENSG00000205359,CTA,23071489,SNP-SNP interactions discovered by logic regression explain Crohn's disease genetics.,2012,10.1371/journal.pone.0043035,https://pubmed.ncbi.nlm.nih.gov/23071489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO6A1,ENSG00000205359,CTA,21383546,The analysis of organic anion transporting polypeptide (OATP) mRNA and protein patterns in primary and metastatic liver cancer.,2011,10.4161/cbt.11.9.15176,https://pubmed.ncbi.nlm.nih.gov/21383546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO6A1,ENSG00000205359,CTA,12677006,Identification and characterization of novel rat and human gonad-specific organic anion transporters.,2003,10.1210/me.2002-0304,https://pubmed.ncbi.nlm.nih.gov/12677006/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
SMC1B,ENSG00000077935,CTA,40867525,Comparative Analysis of Testicular Transcriptional and Translational Landscapes in Yak and Cattle-Yak: Implications for Hybrid Male Sterility.,2025,10.3390/biom15081080,https://pubmed.ncbi.nlm.nih.gov/40867525/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,40180776,Identification of an SMC1B Mutation Associated With Necrozoospermia and Failure of Testi-ICSI : SMC1B Mutation Associated With Necrozoospermia.,2025,10.1007/s43032-025-01828-4,https://pubmed.ncbi.nlm.nih.gov/40180776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,42857607,Roles of meiotic and mitotic cohesin in stem cell gene regulation and genome stability.,2026,10.1016/j.omtn.2026.103100,https://pubmed.ncbi.nlm.nih.gov/42857607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,40537980,A novel non-invasive mRNA-lncRNA biomarker panel for accurate prediction of cervical squamous cell carcinoma and adenocarcinoma.,2025,10.3802/jgo.2025.36.e81,https://pubmed.ncbi.nlm.nih.gov/40537980/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,41565805,Common variation in meiosis genes shapes human recombination and aneuploidy.,2026,10.1038/s41586-025-09964-2,https://pubmed.ncbi.nlm.nih.gov/41565805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,34434933,The Zebrafish Meiotic Cohesin Complex Protein Smc1b Is Required for Key Events in Meiotic Prophase I.,2021,10.3389/fcell.2021.714245,https://pubmed.ncbi.nlm.nih.gov/34434933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,41109371,Single-cell RNA sequencing reveals oocyte-granulosa crosstalk and regulatory networks driving chicken primordial follicle assembly.,2025,10.1016/j.ijbiomac.2025.148357,https://pubmed.ncbi.nlm.nih.gov/41109371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,35848971,Studying the nature of ascending-descending-floating-sinking of Chinese medicines based on gonadotropin-releasing hormone.,2022,10.19852/j.cnki.jtcm.20220516.003,https://pubmed.ncbi.nlm.nih.gov/35848971/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,36179046,Ectopic expression of meiotic cohesin generates chromosome instability in cancer cell line.,2022,10.1073/pnas.2204071119,https://pubmed.ncbi.nlm.nih.gov/36179046/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,37322227,NPHS2-6 drives cervical squamous cell carcinoma (CSCC) progression via hsa-miR-1323/SMC1B axis to activate PI3K-Akt pathway.,2024,10.1007/s12094-023-03248-9,https://pubmed.ncbi.nlm.nih.gov/37322227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,39336750,Positive Selection Drives the Evolution of the Structural Maintenance of Chromosomes (SMC) Complexes.,2024,10.3390/genes15091159,https://pubmed.ncbi.nlm.nih.gov/39336750/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,26673124,SMC1B is present in mammalian somatic cells and interacts with mitotic cohesin proteins.,2015,10.1038/srep18472,https://pubmed.ncbi.nlm.nih.gov/26673124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,30109096,Identification and characterization of circular RNAs in Qinchuan cattle testis.,2018,10.1098/rsos.180413,https://pubmed.ncbi.nlm.nih.gov/30109096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,32917770,Low tolerance for transcriptional variation at cohesin genes is accompanied by functional links to disease-relevant pathways.,2021,10.1136/jmedgenet-2020-107095,https://pubmed.ncbi.nlm.nih.gov/32917770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,35371307,Prognostic Values and Underlying Regulatory Network of Cohesin Subunits in Esophageal Carcinoma.,2022,10.7150/jca.66949,https://pubmed.ncbi.nlm.nih.gov/35371307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,34527684,Clinical Significance and Integrative Analysis of the SMC Family in Hepatocellular Carcinoma.,2021,10.3389/fmed.2021.727965,https://pubmed.ncbi.nlm.nih.gov/34527684/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,38104894,Novel 2 Gene Signatures Associated With Breast Cancer Proliferation: Insights From Predictive Differential Gene Expression Analysis.,2024,10.1016/j.modpat.2023.100403,https://pubmed.ncbi.nlm.nih.gov/38104894/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,28364521,RNA immunoprecipitation identifies novel targets of DAZL in human foetal ovary.,2017,10.1093/molehr/gax004,https://pubmed.ncbi.nlm.nih.gov/28364521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,37655157,Genome instability-derived genes as a novel prognostic signature for lung adenocarcinoma.,2023,10.3389/fcell.2023.1224069,https://pubmed.ncbi.nlm.nih.gov/37655157/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,36689258,Identification of potential prognostic biomarkers in vulval squamous cell carcinoma based on human papillomavirus infection Status-Analysis of GSE183454.,2023,10.1080/01443615.2022.2160930,https://pubmed.ncbi.nlm.nih.gov/36689258/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,30364933,Gene expression profiling informs HPV cervical histopathology but not recurrence/relapse after LEEP in ART-suppressed HIV+HPV+ women.,2019,10.1093/carcin/bgy149,https://pubmed.ncbi.nlm.nih.gov/30364933/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMC1B,ENSG00000077935,CTA,20819778,MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.,2010,10.1093/carcin/bgq177,https://pubmed.ncbi.nlm.nih.gov/20819778/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMIM23,ENSG00000185662,CTA,23028347,A genome-wide association study identifies five loci influencing facial morphology in Europeans.,2012,10.1371/journal.pgen.1002932,https://pubmed.ncbi.nlm.nih.gov/23028347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,41867089,PRMT5/Sohlh2/Sirt1 Signaling Pathway in Vascular Endothelial Cells Modulates Lung Metastasis of Triple-Negative Breast Cancer.,2026,10.1002/advs.74884,https://pubmed.ncbi.nlm.nih.gov/41867089/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,41775083,Sohlh2 inhibited the angiogenesis of hepatocellular carcinoma through the HIF-1α/VEGFA pathway.,2026,10.1016/j.tranon.2026.102718,https://pubmed.ncbi.nlm.nih.gov/41775083/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,41535248,SOHLH2-RAD54L axis induces radioresistance by promoting homologous recombination repair in non-small cell lung cancer.,2026,10.1038/s41420-025-02924-9,https://pubmed.ncbi.nlm.nih.gov/41535248/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,42816179,Epigenetic role of miR-574 in sperm chromatin remodeling and developmental gene networks in male infertility.,2026,10.1071/rd26110,https://pubmed.ncbi.nlm.nih.gov/42816179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,42289696,"Stage-, dose- and course-dependent disruption of mice fetal ovarian development following prenatal dexamethasone exposure.",2026,10.1186/s13048-026-02158-y,https://pubmed.ncbi.nlm.nih.gov/42289696/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,39436118,Sohlh2 Promotes the Progression of Hepatocellular Carcinoma via TGM2-Mediated Autophagy.,2025,10.1002/mc.23832,https://pubmed.ncbi.nlm.nih.gov/39436118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,41579685,"Protective effects of polydatin on cyclophosphamide-induced ovarian and uterine damage in rats via modulation of hormonal, oxidative, inflammatory, and histopathological alterations.",2026,10.1016/j.tice.2026.103309,https://pubmed.ncbi.nlm.nih.gov/41579685/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,41276684,Metabolic reprogramming and mitochondrial dysfunction underlie β gonia arrest and niche cell dysfunction in sterile triploid oysters.,2025,10.1038/s42003-025-09202-5,https://pubmed.ncbi.nlm.nih.gov/41276684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,37875506,Sohlh2 promotes pulmonary fibrosis via repression of p62/Keap1/Nrf2 mediated anti-oxidative signaling pathway.,2023,10.1038/s41419-023-06179-z,https://pubmed.ncbi.nlm.nih.gov/37875506/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,38123542,TRIM21-mediated Sohlh2 ubiquitination suppresses M2 macrophage polarization and progression of triple-negative breast cancer.,2023,10.1038/s41419-023-06383-x,https://pubmed.ncbi.nlm.nih.gov/38123542/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,39245200,Prenatal exposure to environmentally relevant levels of PAHs inhibits spermatogenesis in adult mice and the mechanism involved.,2024,10.1016/j.envpol.2024.124914,https://pubmed.ncbi.nlm.nih.gov/39245200/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,36287177,Sohlh2 Regulates the Stemness and Differentiation of Colon Cancer Stem Cells by Downregulating LncRNA-H19 Transcription.,2023,10.1158/1541-7786.mcr-22-0134,https://pubmed.ncbi.nlm.nih.gov/36287177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,35127476,Sohlh2 Inhibits the Malignant Progression of Renal Cell Carcinoma by Upregulating Klotho via DNMT3a.,2021,10.3389/fonc.2021.769493,https://pubmed.ncbi.nlm.nih.gov/35127476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,39116717,Transcriptomic and metabolomic analyses reveal sex-related differences in the gonads of Pinctada fucata martensii.,2024,10.1016/j.cbd.2024.101304,https://pubmed.ncbi.nlm.nih.gov/39116717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,34899947,Sheng Jing Decoction Can Promote Spermatogenesis and Increase Sperm Motility of the Oligozoospermia Mouse Model.,2021,10.1155/2021/3686494,https://pubmed.ncbi.nlm.nih.gov/34899947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,40460629,Organ-specific lithium accumulation and its toxic effects on female reproduction.,2025,10.1016/j.jhazmat.2025.138516,https://pubmed.ncbi.nlm.nih.gov/40460629/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,34158392,SOHLH2 Suppresses Angiogenesis by Downregulating HIF1α Expression in Breast Cancer.,2021,10.1158/1541-7786.mcr-20-0771,https://pubmed.ncbi.nlm.nih.gov/34158392/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,35605701,"Maternal cypermethrin exposure during perinatal period dysregulates gonadal steroidogenesis, gametogenesis and sperm epigenome in F1 rat offspring.",2022,10.1016/j.reprotox.2022.05.010,https://pubmed.ncbi.nlm.nih.gov/35605701/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,34994166,Initiation of oogenesis and meiosis in the fetal ovary depends on Dennd1a-mediated production of Wnt5a and retinoic acid from the somatic niches.,2021,10.52586/5045,https://pubmed.ncbi.nlm.nih.gov/34994166/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,35504087,N6-methyladenosine RNA demethylase ALKBH5 is testis-specifically downregulated in hybrid male sterile dzo and is a target gene of bta-miR-200a.,2022,10.1016/j.theriogenology.2022.04.022,https://pubmed.ncbi.nlm.nih.gov/35504087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,38593938,Perinatal bisphenol S exposure exacerbates the oxidative burden and apoptosis in neonatal ovaries by suppressing the mTOR/autophagy axis.,2024,10.1016/j.envpol.2024.123939,https://pubmed.ncbi.nlm.nih.gov/38593938/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,31541472,PLZF suppresses differentiation of mouse spermatogonial progenitor cells via binding of differentiation associated genes.,2020,10.1002/jcp.29208,https://pubmed.ncbi.nlm.nih.gov/31541472/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,36303648,Irinotecan (CPT-11) Treatment Induces Mild Gonadotoxicity.,2022,10.3389/frph.2022.812053,https://pubmed.ncbi.nlm.nih.gov/36303648/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH2,ENSG00000120669,CTA,21296871,Coordinated cancer germline antigen promoter and global DNA hypomethylation in ovarian cancer: association with the BORIS/CTCF expression ratio and advanced stage.,2011,10.1158/1078-0432.ccr-10-2315,https://pubmed.ncbi.nlm.nih.gov/21296871/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,42653232,"Whole-Genome Sequencing Identifies Potentially Causative Variants in &lt;i&gt;SOX30&lt;/i&gt;, &lt;i&gt;AKAP4&lt;/i&gt;, and &lt;i&gt;RNF220&lt;/i&gt; in Non-Obstructive Azoospermia.",2026,10.3390/ijms27167230,https://pubmed.ncbi.nlm.nih.gov/42653232/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,42717500,SOX30 Facilitates Triple-Negative Breast Cancer Metastasis via TNFR2-NF-κB Signaling and Tumor Microenvironment Remodeling.,2026,10.1002/advs.77690,https://pubmed.ncbi.nlm.nih.gov/42717500/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,41467312,SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis.,2026,10.1111/cpr.70158,https://pubmed.ncbi.nlm.nih.gov/41467312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,41300700,Molecular Characterization and Expression Patterns of &lt;i&gt;Sox3&lt;/i&gt; and &lt;i&gt;Sox30&lt;/i&gt; Genes and Response to Exogenous Hormones in the Chinese Soft-Shelled Turtle (&lt;i&gt;Pelodiscus sinensis&lt;/i&gt;).,2025,10.3390/genes16111249,https://pubmed.ncbi.nlm.nih.gov/41300700/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,41933221,Systematic evaluation of scallop (Argopecten irradians) SoxH reveals its crucial role in spermiogenesis with limited evidence for sex determination.,2026,10.1038/s42003-026-09959-3,https://pubmed.ncbi.nlm.nih.gov/41933221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,41269228,Mutations of SOX30 are identified in azoospermic human patients and reduce sperm in mice†.,2026,10.1093/biolre/ioaf258,https://pubmed.ncbi.nlm.nih.gov/41269228/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,41566108,SOX30 is a diagnostic biomarker that suppresses ovarian cancer progression through an autophagy mediated mechanism.,2026,10.1007/s12672-026-04472-9,https://pubmed.ncbi.nlm.nih.gov/41566108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,41373817,"SOX18 and SOX30 in NSCLC: The Epigenetic Landscape of Methylation, miRNA Regulation, and Network Crosstalk in Tumor Progression.",2025,10.3390/ijms262311669,https://pubmed.ncbi.nlm.nih.gov/41373817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,42278634,"Integrated Transcriptome Landscape of mRNAs, lncRNAs, circRNAs, and miRNAs Reveals Molecular Regulatory Networks of Sex Differentiation in the Zig-Zag Eel (&lt;i&gt;Mastacembelus armatus&lt;/i&gt;).",2026,10.3390/ijms27115111,https://pubmed.ncbi.nlm.nih.gov/42278634/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,39971903,Single-cell RNA-seq and pathological phenotype reveal the functional atlas and precise roles of Sox30 in testicular cell development and differentiation.,2025,10.1038/s41419-025-07442-1,https://pubmed.ncbi.nlm.nih.gov/39971903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,41905031,PFOS-mediated suppression of SOX30 impairs DNA double-strand break repair leading to male reproductive dysfunction.,2026,10.1016/j.ecoenv.2026.120081,https://pubmed.ncbi.nlm.nih.gov/41905031/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,39824811,NKAPL facilitates transcription pause-release and bridges elongation to initiation during meiosis exit.,2025,10.1038/s41467-024-55579-y,https://pubmed.ncbi.nlm.nih.gov/39824811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,39973138,Deciphering the genetic basis of sex differentiation in silver-lipped pearl oyster ( &lt;i&gt;Pinctada maxima&lt;/i&gt;) based on integrative transcriptomic analysis.,2025,10.24272/j.issn.2095-8137.2024.266,https://pubmed.ncbi.nlm.nih.gov/39973138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,38946929,Multifaceted roles and functions of SOX30 in human cancer.,2024,10.1002/cai2.107,https://pubmed.ncbi.nlm.nih.gov/38946929/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,41356259,A focused evaluation of genetic and epigenetic contributions to common infertility conditions.,2025,10.1177/26334941251399074,https://pubmed.ncbi.nlm.nih.gov/41356259/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,40783914,[Immunological mechanism of non-obstructive azoospermia: An exploration based on bioinformatics and machine learning].,2024,,https://pubmed.ncbi.nlm.nih.gov/40783914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,38132438,SRY-Related Transcription Factors in Head and Neck Squamous Cell Carcinomas: In Silico Based Analysis.,2023,10.3390/cimb45120592,https://pubmed.ncbi.nlm.nih.gov/38132438/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,40187068,Novel genetic associations with childhood adipocytokines in Indian adolescents.,2025,10.1016/j.cyto.2025.156935,https://pubmed.ncbi.nlm.nih.gov/40187068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,39928278,"Exploring miR-34a, miR-449, and ADAM2/ADAM7 Expressions as Potential Biomarkers in Male Infertility: A Combined In Silico and Experimental Approach.",2026,10.1007/s10528-025-11050-1,https://pubmed.ncbi.nlm.nih.gov/39928278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,38936156,The heat shock protein DNAJB8 inhibits pseudorabies virus replication by autophagy.,2024,10.1016/j.vetmic.2024.110165,https://pubmed.ncbi.nlm.nih.gov/38936156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,35836594,"SOX30 Overexpression Reflects Tumor Invasive Degree, Lymph Node Metastasis and Predicts Better Survival in Colorectal Cancer Patients: A Long-Term Follow-Up Cohort Study.",2022,10.3389/fsurg.2022.898952,https://pubmed.ncbi.nlm.nih.gov/35836594/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,37759439,Human Oral Mucosa as a Potentially Effective Source of Neural Crest Stem Cells for Clinical Practice.,2023,10.3390/cells12182216,https://pubmed.ncbi.nlm.nih.gov/37759439/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,29855376,SOX30 is a key regulator of desmosomal gene suppressing tumor growth and metastasis in lung adenocarcinoma.,2018,10.1186/s13046-018-0778-3,https://pubmed.ncbi.nlm.nih.gov/29855376/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,23872309,Comprehensive whole-genome sequencing of an early-stage primary myelofibrosis patient defines low mutational burden and non-recurrent candidate genes.,2013,10.3324/haematol.2013.092379,https://pubmed.ncbi.nlm.nih.gov/23872309/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX30,ENSG00000039600,CTA,10359848,Identification of a novel Sry-related gene and its germ cell-specific expression.,1999,10.1093/nar/27.12.2503,https://pubmed.ncbi.nlm.nih.gov/10359848/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,42149173,Garin3 regulates sperm-oocyte fusion and male fertility.,2026,10.1007/s00018-026-06225-x,https://pubmed.ncbi.nlm.nih.gov/42149173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,38597936,"CCDC28A deficiency causes sperm head defects, reduced sperm motility and male infertility in mice.",2024,10.1007/s00018-024-05184-5,https://pubmed.ncbi.nlm.nih.gov/38597936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,38573307,"Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice.",2024,10.7554/elife.95054,https://pubmed.ncbi.nlm.nih.gov/38573307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,40112915,Spatiotemporal translation of sperm acrosome associated proteins during early capacitation modulates sperm fertilizing ability.,2026,10.1016/j.jare.2025.03.035,https://pubmed.ncbi.nlm.nih.gov/40112915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,41616039,"Identification of deleterious missense variants of serine peptidase inhibitor Kazal type 2 gene and their impact on KAZAL domain structure, stability, flexibility, and dimension.",2026,10.1080/07391102.2026.2618605,https://pubmed.ncbi.nlm.nih.gov/41616039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,39183752,Age-dependent variations in proteomic characteristics of spermatozoa in Simmental bull.,2024,10.3389/fvets.2024.1393706,https://pubmed.ncbi.nlm.nih.gov/39183752/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,40711600,A missense mutation in TCFL5 is associated with male infertility due to oligoasthenoteratozoospermia.,2025,10.1007/s00438-025-02278-y,https://pubmed.ncbi.nlm.nih.gov/40711600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,34172998,Loss of SPACA1 function causes autosomal recessive globozoospermia by damaging the acrosome-acroplaxome complex.,2021,10.1093/humrep/deab144,https://pubmed.ncbi.nlm.nih.gov/34172998/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,34609765,Effects of progesterone nanoparticles on the sperm capacitation and acrosome reaction in asthenozoospermia men.,2022,10.1111/and.14258,https://pubmed.ncbi.nlm.nih.gov/34609765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,37079096,Cryostress induces fragmentation and alters the abundance of sperm transcripts associated with fertilizing competence and reproductive processes in buffalo.,2023,10.1007/s00441-023-03764-8,https://pubmed.ncbi.nlm.nih.gov/37079096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,35616329,Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice.,2022,10.1242/dev.200489,https://pubmed.ncbi.nlm.nih.gov/35616329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,32507260,Characteristics of bull sperm acrosome associated 1 proteins.,2020,10.1016/j.anireprosci.2020.106479,https://pubmed.ncbi.nlm.nih.gov/32507260/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,36047070,Globozoospermia: A Case Report and Systematic Review of Literature.,2023,10.5534/wjmh.220020,https://pubmed.ncbi.nlm.nih.gov/36047070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,35654582,FSIP2 plays a role in the acrosome development during spermiogenesis.,2023,10.1136/jmedgenet-2021-108406,https://pubmed.ncbi.nlm.nih.gov/35654582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,31509916,"Fluoride exposure arrests the acrosome formation during spermatogenesis via down-regulated Zpbp1, Spaca1 and Dpy19l2 expression in rat testes.",2019,10.1016/j.chemosphere.2019.04.019,https://pubmed.ncbi.nlm.nih.gov/31509916/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,35381522,Repression of autophagy leads to acrosome biogenesis disruption caused by a sub-chronic oral administration of polystyrene nanoparticles.,2022,10.1016/j.envint.2022.107220,https://pubmed.ncbi.nlm.nih.gov/35381522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,35793634,The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice.,2022,10.1016/j.celrep.2022.111049,https://pubmed.ncbi.nlm.nih.gov/35793634/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,34231842,CFAP65 is required in the acrosome biogenesis and mitochondrial sheath assembly during spermiogenesis.,2021,10.1093/hmg/ddab185,https://pubmed.ncbi.nlm.nih.gov/34231842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,36379263,Profiling the male germline genome to unravel its reproductive potential.,2023,10.1016/j.fertnstert.2022.11.006,https://pubmed.ncbi.nlm.nih.gov/36379263/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,33357046,Genome-Wide DNA Methylation Pattern of Cancer Stem Cells in Esophageal Cancer.,2020,10.1177/1533033820983793,https://pubmed.ncbi.nlm.nih.gov/33357046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,42826565,Prenatal exposure to Per- and polyfluoroalkyl substances and children's digit ratios based on Shanghai Minhang Birth Cohort: The role of DNA methylation in the placenta.,2026,10.1016/j.ecoenv.2026.120882,https://pubmed.ncbi.nlm.nih.gov/42826565/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA1,ENSG00000118434,CTA,11870081,"SAMP32, a testis-specific, isoantigenic sperm acrosomal membrane-associated protein.",2002,10.1095/biolreprod66.3.735,https://pubmed.ncbi.nlm.nih.gov/11870081/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA4,ENSG00000177202,CTA,41527940,SPACA4 regulates the structure and molecular basis of spermatid maturation and ultimately affects sperm quality in mice.,2026,10.4103/aja202553,https://pubmed.ncbi.nlm.nih.gov/41527940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA4,ENSG00000177202,CTA,37377732,Spermatogenic cell-specific SPACA4 is essential for efficient sperm-zona pellucida binding in vitro.,2023,10.3389/fcell.2023.1204017,https://pubmed.ncbi.nlm.nih.gov/37377732/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA4,ENSG00000177202,CTA,34556579,The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization.,2021,10.1073/pnas.2108777118,https://pubmed.ncbi.nlm.nih.gov/34556579/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA4,ENSG00000177202,CTA,32553959,Identification of new protein biomarkers associated with the boar fertility using iTRAQ-based quantitative proteomic analysis.,2020,10.1016/j.ijbiomac.2020.06.102,https://pubmed.ncbi.nlm.nih.gov/32553959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA4,ENSG00000177202,CTA,36671475,Screening of Tumor Antigens and Construction of Immune Subtypes for mRNA Vaccine Development in Head and Neck Squamous Cell Carcinoma.,2022,10.3390/biom13010090,https://pubmed.ncbi.nlm.nih.gov/36671475/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA4,ENSG00000177202,CTA,36553577,Detection of Selection Signatures in Anqing Six-End-White Pigs Based on Resequencing Data.,2022,10.3390/genes13122310,https://pubmed.ncbi.nlm.nih.gov/36553577/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA4,ENSG00000177202,CTA,32816994,"PGAP6, a GPI-specific phospholipase A2, has narrow substrate specificity against GPI-anchored proteins.",2020,10.1074/jbc.ra120.014643,https://pubmed.ncbi.nlm.nih.gov/32816994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA4,ENSG00000177202,CTA,37549510,Integrated molecular-network analysis reveals infertility-associated key genes and transcription factors in the non-obstructive azoospermia.,2023,10.1016/j.ejogrb.2023.07.023,https://pubmed.ncbi.nlm.nih.gov/37549510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA4,ENSG00000177202,CTA,30190407,The Ly6/uPAR protein Bouncer is necessary and sufficient for species-specific fertilization.,2018,10.1126/science.aat7113,https://pubmed.ncbi.nlm.nih.gov/30190407/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA4,ENSG00000177202,CTA,29342175,Immunocontraceptive target repertoire defined by systematic identification of sperm membrane alloantigens in a single species.,2018,10.1371/journal.pone.0190891,https://pubmed.ncbi.nlm.nih.gov/29342175/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA4,ENSG00000177202,CTA,24012201,Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis.,2013,10.1016/j.fertnstert.2013.07.1999,https://pubmed.ncbi.nlm.nih.gov/24012201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA4,ENSG00000177202,CTA,12788941,"SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction.",2003,10.1074/jbc.m301713200,https://pubmed.ncbi.nlm.nih.gov/12788941/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA5,ENSG00000171489,CTA,40112915,Spatiotemporal translation of sperm acrosome associated proteins during early capacitation modulates sperm fertilizing ability.,2026,10.1016/j.jare.2025.03.035,https://pubmed.ncbi.nlm.nih.gov/40112915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA5,ENSG00000171489,CTA,27895724,Expression profile of SPACA5/Spaca5 in spermatogenesis and transitional cell carcinoma of the bladder.,2016,10.3892/ol.2016.5164,https://pubmed.ncbi.nlm.nih.gov/27895724/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA5,ENSG00000171489,CTA,27611690,In Silico and Biochemical Characterization of Lysozyme-Like Proteins in the Rat.,2016,10.1371/journal.pone.0161909,https://pubmed.ncbi.nlm.nih.gov/27611690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA5,ENSG00000171489,CTA,27832206,"Structural, Functional and Phylogenetic Analysis of Sperm Lysozyme-Like Proteins.",2016,10.1371/journal.pone.0166321,https://pubmed.ncbi.nlm.nih.gov/27832206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA5,ENSG00000171489,CTA,22634100,"335.4 kb microduplication in chromosome band Xp11.2p11.3 associated with developmental delay, growth retardation, autistic disorder and dysmorphic features.",2012,10.1016/j.gene.2012.05.031,https://pubmed.ncbi.nlm.nih.gov/22634100/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA7,ENSG00000153498,CTA,36462395,"Characterization of SPINK2, SPACA7 and PDCL2: Effect of immunization on fecundity, sperm function and testicular transcriptome.",2023,10.1016/j.repbio.2022.100711,https://pubmed.ncbi.nlm.nih.gov/36462395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA7,ENSG00000153498,CTA,40295237,Causal relationships between gut microbiota and male reproductive inflammation and infertility: Insights from Mendelian randomization.,2025,10.1097/md.0000000000042323,https://pubmed.ncbi.nlm.nih.gov/40295237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA7,ENSG00000153498,CTA,40506719,Unraveling the role of HDAC3 as an immunotherapy prognostic biomarker and therapeutic target in advanced non-small cell lung cancer.,2025,10.1186/s12931-025-03275-w,https://pubmed.ncbi.nlm.nih.gov/40506719/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA7,ENSG00000153498,CTA,24307706,SPACA7 is a novel male germ cell-specific protein localized to the sperm acrosome that is involved in fertilization in mice.,2014,10.1095/biolreprod.113.111831,https://pubmed.ncbi.nlm.nih.gov/24307706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA7,ENSG00000153498,CTA,22495889,Identification of a new mouse sperm acrosome-associated protein.,2012,10.1530/rep-11-0270,https://pubmed.ncbi.nlm.nih.gov/22495889/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11A,ENSG00000178287,CTA,38446746,Comparison of SPAG11A gene expression in infertile men with grade 1 and 2 varicocele before and after treatment.,2024,10.5935/1518-0557.20220060,https://pubmed.ncbi.nlm.nih.gov/38446746/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11A,ENSG00000178287,CTA,39020527,Effect of Spag11a gene knockout on the epididymis in mice: A histopathological and molecular analyses.,2024,10.1002/cbf.4096,https://pubmed.ncbi.nlm.nih.gov/39020527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11A,ENSG00000178287,CTA,39425448,The Sperm-Associated Antigen 11A (Spag11a) Knockout Mice Display Sub-Fertility and Perturbations in the Sperm Proteome.,2024,10.1002/cbf.70003,https://pubmed.ncbi.nlm.nih.gov/39425448/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11A,ENSG00000178287,CTA,42254241,The influence of unhealthy lifestyle on semen quality: results from a cross-sectional study and Mendelian randomization analysis.,2026,10.1097/ms9.0000000000004982,https://pubmed.ncbi.nlm.nih.gov/42254241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11A,ENSG00000178287,CTA,40295237,Causal relationships between gut microbiota and male reproductive inflammation and infertility: Insights from Mendelian randomization.,2025,10.1097/md.0000000000042323,https://pubmed.ncbi.nlm.nih.gov/40295237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11A,ENSG00000178287,CTA,35438340,Ablation of the sperm-associated antigen 11A (SPAG11A) protein by active immunization promotes epididymal oncogenesis in the rat.,2022,10.1007/s00441-022-03623-y,https://pubmed.ncbi.nlm.nih.gov/35438340/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11A,ENSG00000178287,CTA,32927355,Transgenesis and active immunization mediated reduction of sperm associated antigen 11A mRNA and protein levels affect fecundity in the rat.,2020,10.1016/j.theriogenology.2020.08.027,https://pubmed.ncbi.nlm.nih.gov/32927355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11A,ENSG00000178287,CTA,32363846,Seasonal expressions of SPAG11A and androgen receptor in the epididymis of the wild ground squirrels (Citellus dauricus Brandt).,2020,10.4081/ejh.2020.3111,https://pubmed.ncbi.nlm.nih.gov/32363846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11A,ENSG00000178287,CTA,31691005,siRNA-mediated knockdown of sperm-associated antigen 11a (Spag11a) mRNA in epididymal primary epithelial cells affects proliferation: a transcriptome analyses.,2020,10.1007/s00441-019-03107-6,https://pubmed.ncbi.nlm.nih.gov/31691005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11A,ENSG00000178287,CTA,31637753,"Tlr1-13, Nod1/2 and antimicrobial gene expression in the epididymis and testis of rats with alloxan-induced diabetes.",2019,10.1111/and.13437,https://pubmed.ncbi.nlm.nih.gov/31637753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11A,ENSG00000178287,CTA,23815807,Sperm-associated antigen 11A is expressed exclusively in the principal cells of the mouse caput epididymis in an androgen-dependent manner.,2013,10.1186/1477-7827-11-59,https://pubmed.ncbi.nlm.nih.gov/23815807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11A,ENSG00000178287,CTA,33718161,"A Survival-Related Competitive Endogenous RNA Network of Prognostic lncRNAs, miRNAs, and mRNAs in Wilms Tumor.",2021,10.3389/fonc.2021.608433,https://pubmed.ncbi.nlm.nih.gov/33718161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11A,ENSG00000178287,CTA,31701684,Identification of a five-mRNA signature as a novel potential prognostic biomarker in pediatric Wilms tumor.,2020,10.1002/mgg3.1032,https://pubmed.ncbi.nlm.nih.gov/31701684/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11A,ENSG00000178287,CTA,30661062,Development of a prognostic index based on an immunogenomic landscape analysis of papillary thyroid cancer.,2019,10.18632/aging.101754,https://pubmed.ncbi.nlm.nih.gov/30661062/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11A,ENSG00000178287,CTA,25099571,Androgenic regulation of beta-defensins in the mouse epididymis.,2014,10.1186/1477-7827-12-76,https://pubmed.ncbi.nlm.nih.gov/25099571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11A,ENSG00000178287,CTA,8167223,Molecular cloning and characterization of a novel human sperm antigen (HE2) specifically expressed in the proximal epididymis.,1994,10.1095/biolreprod50.3.516,https://pubmed.ncbi.nlm.nih.gov/8167223/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11B,ENSG00000164871,CTA,40468462,"SPAG11B, a potential biomarker for rheumatoid arthritis: a two-sample bidirectional Mendelian randomization analysis.",2025,10.1186/s41927-025-00521-y,https://pubmed.ncbi.nlm.nih.gov/40468462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11B,ENSG00000164871,CTA,39254691,Identification of novel protein biomarkers and therapeutic targets for ankylosing spondylitis using human circulating plasma proteomics and genome analysis.,2024,10.1007/s00216-024-05521-4,https://pubmed.ncbi.nlm.nih.gov/39254691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11B,ENSG00000164871,CTA,41407891,Mendelian randomization and bioinformatics analysis identify the association between plasma proteins and cataract.,2025,10.1038/s41598-025-33095-3,https://pubmed.ncbi.nlm.nih.gov/41407891/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11B,ENSG00000164871,CTA,40295237,Causal relationships between gut microbiota and male reproductive inflammation and infertility: Insights from Mendelian randomization.,2025,10.1097/md.0000000000042323,https://pubmed.ncbi.nlm.nih.gov/40295237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11B,ENSG00000164871,CTA,19535787,Novel partners of SPAG11B isoform D in the human male reproductive tract.,2009,10.1095/biolreprod.109.077545,https://pubmed.ncbi.nlm.nih.gov/19535787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11B,ENSG00000164871,CTA,25657045,Dynamic changes in the spatio-temporal expression of the β-defensin SPAG11C in the developing rat epididymis and its regulation by androgens.,2015,10.1016/j.mce.2015.01.013,https://pubmed.ncbi.nlm.nih.gov/25657045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11B,ENSG00000164871,CTA,21933954,Verification of male infertility biomarkers in seminal plasma by multiplex selected reaction monitoring assay.,2011,10.1074/mcp.m110.004127,https://pubmed.ncbi.nlm.nih.gov/21933954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11B,ENSG00000164871,CTA,25099571,Androgenic regulation of beta-defensins in the mouse epididymis.,2014,10.1186/1477-7827-12-76,https://pubmed.ncbi.nlm.nih.gov/25099571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11B,ENSG00000164871,CTA,20505168,Alterations in the human blood-epididymis barrier in obstructive azoospermia and the development of novel epididymal cell lines from infertile men.,2010,10.1095/biolreprod.110.084459,https://pubmed.ncbi.nlm.nih.gov/20505168/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG11B,ENSG00000164871,CTA,8167223,Molecular cloning and characterization of a novel human sperm antigen (HE2) specifically expressed in the proximal epididymis.,1994,10.1095/biolreprod50.3.516,https://pubmed.ncbi.nlm.nih.gov/8167223/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,41716467,Potency-enhancing mutations in E3-19K and i-leader increase the cytolytic activity of the PH20/&lt;i&gt;SPAM1&lt;/i&gt;-armed oncolytic adenovirus Ad5Δ24RGD.,2026,10.1016/j.omton.2026.201137,https://pubmed.ncbi.nlm.nih.gov/41716467/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,39056785,Genetic Deficiencies of Hyaluronan Degradation.,2024,10.3390/cells13141203,https://pubmed.ncbi.nlm.nih.gov/39056785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,42678488,"Investigating the Pharmacokinetics, Injection Speed, and Usability of Subcutaneous Efgartigimod PH20 Administered with a Prefilled Syringe.",2026,10.1007/s12325-026-03733-x,https://pubmed.ncbi.nlm.nih.gov/42678488/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,42723554,"Efficacy and safety of subcutaneous efgartigimod with prednisone in moderate-to-severe pemphigus (ADDRESS): a global, phase III, randomised controlled, double-blind trial.",2026,10.1093/bjd/ljag199,https://pubmed.ncbi.nlm.nih.gov/42723554/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,41863098,Novel small-molecule positive allosteric modulator 1 with blood-brain barrier penetration activity exerts anti-cellular senescence effects via the PAC1-R/YY1/SIRT6 pathway.,2026,10.3724/abbs.2026032,https://pubmed.ncbi.nlm.nih.gov/41863098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,42038295,HYAL3 as a therapeutic target for pulmonary arterial Hypertension-Cardiomyopathy comorbidity: an integrative analysis combined with machine learning and SHAP value interpretation.,2026,10.3389/fphar.2026.1759555,https://pubmed.ncbi.nlm.nih.gov/42038295/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,42698547,Hyaluronidase treatment is associated with increased cytokine levels and reduced peritoneal neutrophil accumulation during LPS-induced inflammation.,2026,10.3389/fphar.2026.1869630,https://pubmed.ncbi.nlm.nih.gov/42698547/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,42756066,"Hyaluronidase-enhanced delivery in gene therapy and regenerative medicine for improved vector, cell, and cargo access.",2026,10.3389/fddev.2026.1906950,https://pubmed.ncbi.nlm.nih.gov/42756066/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,41458179,PH20-modified exosomes loaded curcumin inhibit desmoplastic breast cancer by breaking extracellular matrix barrier and normalizing cancer-associated fibroblasts.,2025,10.1016/j.mtbio.2025.102635,https://pubmed.ncbi.nlm.nih.gov/41458179/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,42699831,"Long-term safety, tolerability, and efficacy of subcutaneous efgartigimod PH20 in generalized myasthenia gravis: final results from a phase 3 open-label extension study (ADAPT-SC+).",2026,10.3389/fneur.2026.1876344,https://pubmed.ncbi.nlm.nih.gov/42699831/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,42155755,Aromatic interactions surrounding the Asp-X-Glu motif stabilize the active site of HYAL1 and PH20.,2026,10.1016/j.bbapap.2026.141150,https://pubmed.ncbi.nlm.nih.gov/42155755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,42463457,Long-Term Safety and Efficacy of Efgartigimod PH20 in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: ADHERE/ADHERE+ Trial Interim Analysis.,2026,10.1111/jns.70140,https://pubmed.ncbi.nlm.nih.gov/42463457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,42590898,rHuPH20 Enhances Extravascular Delivery of mRNA Lipid Nanoparticles in Mice and Minipigs.,2026,10.1177/21593337261479163,https://pubmed.ncbi.nlm.nih.gov/42590898/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,41096909,Connections Between Gene Polymorphism and Fetlock and Hock Measurements in Polish Sport Horses.,2025,10.3390/ijms26199645,https://pubmed.ncbi.nlm.nih.gov/41096909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,40332328,Comparison of the L3-23K and L5-Fiber Regions for Arming the Oncolytic Adenovirus Ad5-Delta-24-RGD with Reporter and Therapeutic Transgenes.,2025,10.3390/ijms26083700,https://pubmed.ncbi.nlm.nih.gov/40332328/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,41681979,"Phase II Study of Pegvorhyaluronidase Alfa (PEGPH20) and Pembrolizumab for Patients with Hyaluronan-High, Pretreated Metastatic Pancreatic Ductal Adenocarcinoma: PCRT16-001.",2026,10.3390/cancers18030507,https://pubmed.ncbi.nlm.nih.gov/41681979/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,41935547,"Recombinant human hyaluronidase PH20 facilitates rapid subcutaneous infusion: two randomized, double-blind, self-controlled phase III clinical trials.",2026,10.1016/j.ejpb.2026.115070,https://pubmed.ncbi.nlm.nih.gov/41935547/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,42025703,GLUL deficiency causes sperm acrosome defects and male infertility via influencing redox balance in mice.,2026,10.1016/j.freeradbiomed.2026.04.030,https://pubmed.ncbi.nlm.nih.gov/42025703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,42171942,Enhanced subcutaneous delivery of antibody-drug conjugates with recombinant human hyaluronidase PH20: pharmacokinetics and tolerability in minipigs.,2026,10.1007/s13346-026-02144-3,https://pubmed.ncbi.nlm.nih.gov/42171942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,39910555,Engineered CAF-cancer cell hybrid membrane biomimetic dual-targeted integrated platform for multi-dimensional treatment of ovarian cancer.,2025,10.1186/s12951-025-03165-9,https://pubmed.ncbi.nlm.nih.gov/39910555/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,41589716,Removal of Interstitial Hyaluronan Facilitates Subcutaneous Administration and Lymphatic Delivery of Anti-CTLA4 and Improves Antitumor Efficacy.,2026,10.1158/2326-6066.cir-25-0256,https://pubmed.ncbi.nlm.nih.gov/41589716/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,41551508,"Efficacy and safety of efgartigimod PH20 SC for Sjögren's disease-associated dryness: study protocol for an investigator-initiated, multicenter, phase 2, randomized, double-blind, placebo-controlled trial (OASIS study).",2025,10.3389/fmed.2025.1719757,https://pubmed.ncbi.nlm.nih.gov/41551508/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,41943179,"Efficacy and Safety of Subcutaneous Efgartigimod PH20 in Adults With Primary Immune Thrombocytopenia (ADVANCE SC): A Multicenter, Randomized, Double-Blinded, Placebo-Controlled, Phase 3 Trial.",2026,10.1002/ajh.70303,https://pubmed.ncbi.nlm.nih.gov/41943179/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,42128722,"Corrigendum to 'Diagnostic adjudication of potential participants with chronic inflammatory demyelinating polyradiculoneuropathy in the ADHERE trial of subcutaneous efgartigimod PH20' [Journal of the Neurological Sciences, 486 (2026) 125918].",2026,10.1016/j.jns.2026.125965,https://pubmed.ncbi.nlm.nih.gov/42128722/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,42461495,Transitioning Therapeutic Antibodies in Oncology from Intravenous to Hyaluronidase-Facilitated Subcutaneous Administration.,2026,10.1007/s40262-026-01669-7,https://pubmed.ncbi.nlm.nih.gov/42461495/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,41950575,Real-world experience with switching from intravenous immunoglobulin to subcutaneous efgartigimod PH20 in patients with chronic inflammatory demyelinating polyradiculoneuropathy: A case series.,2026,10.1016/j.jneuroim.2026.578925,https://pubmed.ncbi.nlm.nih.gov/41950575/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,41517815,"Efficacy, Safety, and Tolerability of Subcutaneous Efgartigimod PH20 in Chinese Patients With Chronic Inflammatory Demyelinating Polyneuropathy: A Prespecified Subpopulation Analysis of the Multicentre, Randomised-Withdrawal, Double-Blind, Placebo-Controlled, Phase II ADHERE Trial.",2026,10.3988/jcn.2025.0247,https://pubmed.ncbi.nlm.nih.gov/41517815/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,41052885,Pharmacokinetics and safety of subcutaneous nivolumab: results from the phase I/II CheckMate 8KX study.,2025,10.1136/jitc-2025-011918,https://pubmed.ncbi.nlm.nih.gov/41052885/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAM1,ENSG00000106304,CTA,8234258,Molecular cloning of the human and monkey sperm surface protein PH-20.,1993,10.1073/pnas.90.21.10071,https://pubmed.ncbi.nlm.nih.gov/8234258/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA1,ENSG00000198021,CTA,33175201,Hypomethylated SPANXA1/A2 promotes the metastasis of head and neck squamous cell carcinoma.,2020,10.1007/s12032-020-01441-2,https://pubmed.ncbi.nlm.nih.gov/33175201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA1,ENSG00000198021,CTA,27323831,SPANXA suppresses EMT by inhibiting c-JUN/SNAI2 signaling in lung adenocarcinoma.,2016,10.18632/oncotarget.10088,https://pubmed.ncbi.nlm.nih.gov/27323831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA1,ENSG00000198021,CTA,31289536,Iodine promotes thyroid cancer development via SPANXA1 through the PI3K/AKT signalling pathway.,2019,10.3892/ol.2019.10391,https://pubmed.ncbi.nlm.nih.gov/31289536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA1,ENSG00000198021,CTA,33290900,Biological features of tissue and bone sarcomas investigated using an in vitro model of clonal selection.,2021,10.1016/j.prp.2020.153214,https://pubmed.ncbi.nlm.nih.gov/33290900/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA1,ENSG00000198021,CTA,29453317,Histone H3.3K27M Mobilizes Multiple Cancer/Testis (CT) Antigens in Pediatric Glioma.,2018,10.1158/1541-7786.mcr-17-0460,https://pubmed.ncbi.nlm.nih.gov/29453317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA1,ENSG00000198021,CTA,26317029,A Panel of Cancer Testis Antigens and Clinical Risk Factors to Predict Metastasis in Colorectal Cancer.,2014,10.1155/2014/272683,https://pubmed.ncbi.nlm.nih.gov/26317029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA1,ENSG00000198021,CTA,26885621,Novel potential serological prostate cancer biomarkers using CT100+ cancer antigen microarray platform in a multi-cultural South African cohort.,2016,10.18632/oncotarget.7359,https://pubmed.ncbi.nlm.nih.gov/26885621/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA1,ENSG00000198021,CTA,17012309,Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis.,2006,10.1093/molehr/gal079,https://pubmed.ncbi.nlm.nih.gov/17012309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA1,ENSG00000198021,CTA,23574628,"Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene.",2013,10.1111/tan.12113,https://pubmed.ncbi.nlm.nih.gov/23574628/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA1,ENSG00000198021,CTA,22737227,Genome-wide profiling of pluripotent cells reveals a unique molecular signature of human embryonic germ cells.,2012,10.1371/journal.pone.0039088,https://pubmed.ncbi.nlm.nih.gov/22737227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA1,ENSG00000198021,CTA,12758128,"The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines.",2003,10.1016/s0378-1119(03)00497-9,https://pubmed.ncbi.nlm.nih.gov/12758128/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA1,ENSG00000198021,CTA,20073942,SPANX gene variation in fertile and infertile males.,2010,10.3109/19396360903312015,https://pubmed.ncbi.nlm.nih.gov/20073942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA1,ENSG00000198021,CTA,10906052,Spermatid-specific expression of the novel X-linked gene product SPAN-X localized to the nucleus of human spermatozoa.,2000,10.1093/biolreprod/63.2.469,https://pubmed.ncbi.nlm.nih.gov/10906052/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA2,ENSG00000203926,CTA,41066194,A systems approach to target discovery identifies the role of lncRNA-SPANXA2-OT1 in macrophage chemotaxis.,2025,10.1172/jci.insight.191274,https://pubmed.ncbi.nlm.nih.gov/41066194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA2,ENSG00000203926,CTA,34646842,LncRNA SPANXA2-OT1 Participates in the Occurrence and Development of EMT in Calcium Oxalate Crystal-Induced Kidney Injury by Adsorbing miR-204 and Up-Regulating Smad5.,2021,10.3389/fmed.2021.719980,https://pubmed.ncbi.nlm.nih.gov/34646842/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA2,ENSG00000203926,CTA,27323831,SPANXA suppresses EMT by inhibiting c-JUN/SNAI2 signaling in lung adenocarcinoma.,2016,10.18632/oncotarget.10088,https://pubmed.ncbi.nlm.nih.gov/27323831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA2,ENSG00000203926,CTA,26317029,A Panel of Cancer Testis Antigens and Clinical Risk Factors to Predict Metastasis in Colorectal Cancer.,2014,10.1155/2014/272683,https://pubmed.ncbi.nlm.nih.gov/26317029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA2,ENSG00000203926,CTA,17012309,Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis.,2006,10.1093/molehr/gal079,https://pubmed.ncbi.nlm.nih.gov/17012309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA2,ENSG00000203926,CTA,12758128,"The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines.",2003,10.1016/s0378-1119(03)00497-9,https://pubmed.ncbi.nlm.nih.gov/12758128/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA2,ENSG00000203926,CTA,20073942,SPANX gene variation in fertile and infertile males.,2010,10.3109/19396360903312015,https://pubmed.ncbi.nlm.nih.gov/20073942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXA2,ENSG00000203926,CTA,10906052,Spermatid-specific expression of the novel X-linked gene product SPAN-X localized to the nucleus of human spermatozoa.,2000,10.1093/biolreprod/63.2.469,https://pubmed.ncbi.nlm.nih.gov/10906052/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXB1,ENSG00000227234,CTA,40885703,SPANXB1 drives brain metastasis in breast cancer via MMP1 regulation: potential therapeutic insights with metformin.,2025,10.1038/s41420-025-02721-4,https://pubmed.ncbi.nlm.nih.gov/40885703/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXB1,ENSG00000227234,CTA,42899482,Tumour Antigen-Specific Antibody Signatures as Diagnostic Biomarkers for Melanoma.,2026,10.1002/ijc.70726,https://pubmed.ncbi.nlm.nih.gov/42899482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXB1,ENSG00000227234,CTA,41129177,Multiomic Selection of Cancer-Testis Antigens as Precision Immuno-oncologic Targets in Head and Neck Cancer.,2025,10.1001/jamaoto.2025.3563,https://pubmed.ncbi.nlm.nih.gov/41129177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXB1,ENSG00000227234,CTA,37057240,Identification of Cancer/Testis Antigens Related to Gastric Cancer Prognosis Based on Co-Expression Network and Integrated Transcriptome Analyses.,2023,10.4103/abr.abr_400_21,https://pubmed.ncbi.nlm.nih.gov/37057240/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXB1,ENSG00000227234,CTA,31406142,Cancer Testis Antigen Promotes Triple Negative Breast Cancer Metastasis and is Traceable in the Circulating Extracellular Vesicles.,2019,10.1038/s41598-019-48064-w,https://pubmed.ncbi.nlm.nih.gov/31406142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXB1,ENSG00000227234,CTA,35096583,Screening and Identification of Novel Potential Biomarkers for Breast Cancer Brain Metastases.,2021,10.3389/fonc.2021.784096,https://pubmed.ncbi.nlm.nih.gov/35096583/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXB1,ENSG00000227234,CTA,35663320,The Role of Testosterone in Spermatogenesis: Lessons From Proteome Profiling of Human Spermatozoa in Testosterone Deficiency.,2022,10.3389/fendo.2022.852661,https://pubmed.ncbi.nlm.nih.gov/35663320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXB1,ENSG00000227234,CTA,39016139,Construction of a Liver Cancer Prognostic Model Based on Interferon-Gamma-Related Genes for Revealing the Immune Landscape.,2024,10.1615/jenvironpatholtoxicoloncol.2024049848,https://pubmed.ncbi.nlm.nih.gov/39016139/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXB1,ENSG00000227234,CTA,29453317,Histone H3.3K27M Mobilizes Multiple Cancer/Testis (CT) Antigens in Pediatric Glioma.,2018,10.1158/1541-7786.mcr-17-0460,https://pubmed.ncbi.nlm.nih.gov/29453317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXB1,ENSG00000227234,CTA,33200223,Evaluating the biological functions of the prognostic genes identified by the Pathology Atlas in bladder cancer.,2021,10.3892/or.2020.7853,https://pubmed.ncbi.nlm.nih.gov/33200223/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXB1,ENSG00000227234,CTA,23574628,"Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene.",2013,10.1111/tan.12113,https://pubmed.ncbi.nlm.nih.gov/23574628/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXB1,ENSG00000227234,CTA,23455884,Comparative proteomic study between human normal motility sperm and idiopathic asthenozoospermia.,2013,10.1007/s00345-013-1023-5,https://pubmed.ncbi.nlm.nih.gov/23455884/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXB1,ENSG00000227234,CTA,17690704,Combined high-resolution array-based comparative genomic hybridization and expression profiling of ETV6/RUNX1-positive acute lymphoblastic leukemias reveal a high incidence of cryptic Xq duplications and identify several putative target genes within the commonly gained region.,2007,10.1038/sj.leu.2404879,https://pubmed.ncbi.nlm.nih.gov/17690704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXB1,ENSG00000227234,CTA,12758128,"The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines.",2003,10.1016/s0378-1119(03)00497-9,https://pubmed.ncbi.nlm.nih.gov/12758128/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXB1,ENSG00000227234,CTA,14734458,"Genomic organization, incidence, and localization of the SPAN-x family of cancer-testis antigens in melanoma tumors and cell lines.",2004,10.1158/1078-0432.ccr-0647-3,https://pubmed.ncbi.nlm.nih.gov/14734458/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXB1,ENSG00000227234,CTA,17012309,Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis.,2006,10.1093/molehr/gal079,https://pubmed.ncbi.nlm.nih.gov/17012309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXB1,ENSG00000227234,CTA,20073942,SPANX gene variation in fertile and infertile males.,2010,10.3109/19396360903312015,https://pubmed.ncbi.nlm.nih.gov/20073942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXB1,ENSG00000227234,CTA,10906052,Spermatid-specific expression of the novel X-linked gene product SPAN-X localized to the nucleus of human spermatozoa.,2000,10.1093/biolreprod/63.2.469,https://pubmed.ncbi.nlm.nih.gov/10906052/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXC,ENSG00000198573,CTA,31483565,Hypomethylation-activated cancer-testis gene SPANXC promotes cell metastasis in lung adenocarcinoma.,2019,10.1111/jcmm.14532,https://pubmed.ncbi.nlm.nih.gov/31483565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXC,ENSG00000198573,CTA,23574628,"Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene.",2013,10.1111/tan.12113,https://pubmed.ncbi.nlm.nih.gov/23574628/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXC,ENSG00000198573,CTA,17012309,Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis.,2006,10.1093/molehr/gal079,https://pubmed.ncbi.nlm.nih.gov/17012309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXC,ENSG00000198573,CTA,12758128,"The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines.",2003,10.1016/s0378-1119(03)00497-9,https://pubmed.ncbi.nlm.nih.gov/12758128/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXC,ENSG00000198573,CTA,10626816,"CTp11, a novel member of the family of human cancer/testis antigens.",1999,,https://pubmed.ncbi.nlm.nih.gov/10626816/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXD,ENSG00000196406,CTA,41129177,Multiomic Selection of Cancer-Testis Antigens as Precision Immuno-oncologic Targets in Head and Neck Cancer.,2025,10.1001/jamaoto.2025.3563,https://pubmed.ncbi.nlm.nih.gov/41129177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXD,ENSG00000196406,CTA,26625006,Hypermethylation of genes in testicular embryonal carcinomas.,2016,10.1038/bjc.2015.408,https://pubmed.ncbi.nlm.nih.gov/26625006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXD,ENSG00000196406,CTA,17012309,Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis.,2006,10.1093/molehr/gal079,https://pubmed.ncbi.nlm.nih.gov/17012309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXD,ENSG00000196406,CTA,12758128,"The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines.",2003,10.1016/s0378-1119(03)00497-9,https://pubmed.ncbi.nlm.nih.gov/12758128/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXN5,ENSG00000204363,CTA,39391249,Molecular genetic characterization of myeloid neoplasms with idic(X)(q13) and i(X)(q10).,2024,10.3389/fonc.2024.1428984,https://pubmed.ncbi.nlm.nih.gov/39391249/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA12,ENSG00000186451,CTA,38438916,"RGA1 regulates grain size, rice quality and seed germination in the small and round grain mutant srg5.",2024,10.1186/s12870-024-04864-5,https://pubmed.ncbi.nlm.nih.gov/38438916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA12,ENSG00000186451,CTA,29467887,Role and underlying mechanism of SPATA12 in oxidative damage.,2018,10.3892/ol.2018.7749,https://pubmed.ncbi.nlm.nih.gov/29467887/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA12,ENSG00000186451,CTA,22561491,[Experimental study of inhibition of tumor cell proliferation by a novel gene SPATA12].,2012,10.3969/j.issn.1672-7347.2012.03.002,https://pubmed.ncbi.nlm.nih.gov/22561491/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA12,ENSG00000186451,CTA,24205157,SPATA12 and its possible role in DNA damage induced by ultraviolet-C.,2013,10.1371/journal.pone.0078201,https://pubmed.ncbi.nlm.nih.gov/24205157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA12,ENSG00000186451,CTA,22981541,Transcriptional regulation of human novel gene SPATA12 promoter by AP-1 and HSF.,2012,10.1016/j.gene.2012.08.047,https://pubmed.ncbi.nlm.nih.gov/22981541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA12,ENSG00000186451,CTA,17251597,Expression and possible functions of a novel gene SPATA12 in human testis.,2007,10.2164/jandrol.106.001560,https://pubmed.ncbi.nlm.nih.gov/17251597/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA12,ENSG00000186451,CTA,28582417,Genome-wide alteration in DNA hydroxymethylation in the sperm from bisphenol A-exposed men.,2017,10.1371/journal.pone.0178535,https://pubmed.ncbi.nlm.nih.gov/28582417/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA12,ENSG00000186451,CTA,15603706,Identification and expression of a novel human testis-specific gene by digital differential display.,2004,,https://pubmed.ncbi.nlm.nih.gov/15603706/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA12,ENSG00000186451,CTA,23292202,Microarray-based analysis of the gene expression profile in GC-1 spg             cells transfected with spermatogenesis associated gene 12.,2013,10.3892/ijmm.2012.1225,https://pubmed.ncbi.nlm.nih.gov/23292202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA12,ENSG00000186451,CTA,15490870,[Molecular cloning and expression analysis of a novel human testis-specific gene].,2004,,https://pubmed.ncbi.nlm.nih.gov/15490870/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,42201145,Methadone Maintenance Treatment vs. Long-Term Abstinence Without Opioid Agonist: Epigenome-Wide Study of DNA Methylation.,2026,10.3390/epigenomes10020029,https://pubmed.ncbi.nlm.nih.gov/42201145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,41182493,"Curcumin mitigates heat stress-induced gonadal dysfunction in roosters: insights from semen, histology, and transcriptome analysis.",2025,10.1007/s11250-025-04713-z,https://pubmed.ncbi.nlm.nih.gov/41182493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,38253538,Molecular quantitative trait loci in reproductive tissues impact male fertility in cattle.,2024,10.1038/s41467-024-44935-7,https://pubmed.ncbi.nlm.nih.gov/38253538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,39201790,Comprehensive Analysis of Methylome and Transcriptome to Identify Potential Genes Regulating Porcine Testis Development.,2024,10.3390/ijms25169105,https://pubmed.ncbi.nlm.nih.gov/39201790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,41247592,Host genetic determinants of resistance and susceptibility to bovine leukemia virus infection: A mini-review.,2025,10.1007/s11033-025-11230-7,https://pubmed.ncbi.nlm.nih.gov/41247592/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,40376536,Establishment and clinical significance of genetic factor screening method for patients with nonobstructive azoospermia based on whole exon sequencing technology.,2025,10.21037/tau-2024-676,https://pubmed.ncbi.nlm.nih.gov/40376536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,40571737,Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression.,2025,10.1038/s41380-025-03084-z,https://pubmed.ncbi.nlm.nih.gov/40571737/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,39045326,"Atypical structure of the nuclear membrane, distribution of nuclear pores and lamin B1 in spermatozoa of patients with complete and partial globozoospermia.",2024,10.3389/fgene.2024.1427838,https://pubmed.ncbi.nlm.nih.gov/39045326/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,37895049,A Comprehensive Genetic Study of Microtubule-Associated Gene Clusters for Male Infertility in a Taiwanese Cohort.,2023,10.3390/ijms242015363,https://pubmed.ncbi.nlm.nih.gov/37895049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,33784962,Autosomal recessive loci contribute significantly to quantitative variation of male fertility in a dairy cattle population.,2021,10.1186/s12864-021-07523-3,https://pubmed.ncbi.nlm.nih.gov/33784962/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,35248021,"Association of CATSPER1, SPATA16 and TEX11 genes polymorphism with idiopathic azoospermia and oligospermia risk in Iranian population.",2022,10.1186/s12920-022-01197-w,https://pubmed.ncbi.nlm.nih.gov/35248021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,36177775,SPATA16 promoter hypermethylation and downregulation in male infertility.,2022,10.1111/and.14548,https://pubmed.ncbi.nlm.nih.gov/36177775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,35737328,Single-Nucleotide Polymorphism on Spermatogenesis Associated 16 Gene-Coding Region Affecting Bovine Leukemia Virus Proviral Load.,2022,10.3390/vetsci9060275,https://pubmed.ncbi.nlm.nih.gov/35737328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,29065458,Human Globozoospermia-Related Gene Spata16 Is Required for Sperm Formation Revealed by CRISPR/Cas9-Mediated Mouse Models.,2017,10.3390/ijms18102208,https://pubmed.ncbi.nlm.nih.gov/29065458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,31985809,Exome sequencing reveals novel causes as well as new candidate genes for human globozoospermia.,2020,10.1093/humrep/dez246,https://pubmed.ncbi.nlm.nih.gov/31985809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,35709667,Mixed model-based eQTL analysis reveals lncRNAs associated with regulation of genes involved in sex determination and spermatogenesis: The key to understanding human gender imbalance.,2022,10.1016/j.compbiolchem.2022.107713,https://pubmed.ncbi.nlm.nih.gov/35709667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,32054438,"Population-specific, recent positive directional selection suggests adaptation of human male reproductive genes to different environmental conditions.",2020,10.1186/s12862-019-1575-0,https://pubmed.ncbi.nlm.nih.gov/32054438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,34209343,"Molecular Analysis of DPY19L2, PICK1 and SPATA16 in Italian Unrelated Globozoospermic Men.",2021,10.3390/life11070641,https://pubmed.ncbi.nlm.nih.gov/34209343/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,33877510,Single-center thorough evaluation and targeted treatment of globozoospermic men.,2021,10.1007/s10815-021-02191-4,https://pubmed.ncbi.nlm.nih.gov/33877510/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,28355295,Risk prediction of pulmonary tuberculosis using genetic and conventional risk factors in adult Korean population.,2017,10.1371/journal.pone.0174642,https://pubmed.ncbi.nlm.nih.gov/28355295/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA16,ENSG00000144962,CTA,12529416,"Identification and characterization of a novel human testis-specific Golgi protein, NYD-SP12.",2003,10.1093/molehr/gag005,https://pubmed.ncbi.nlm.nih.gov/12529416/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA19,ENSG00000166118,CTA,41285782,The S-depalmitoylase ABHD10 is essential for sperm mitochondrial sheath formation and male fertility.,2025,10.1038/s41467-025-65300-2,https://pubmed.ncbi.nlm.nih.gov/41285782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA19,ENSG00000166118,CTA,41746104,Immunization Against a Conserved Short 13-Amino Acid Receptor-Binding Epitope of FSHβ Reduces Spermatogenesis and Sperm Motility in Male Mice.,2026,10.3390/vaccines14020184,https://pubmed.ncbi.nlm.nih.gov/41746104/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA19,ENSG00000166118,CTA,37694540,The anti-spermatogenic activity of nanoliposomes loaded with Heracleum persicum phenolic compounds in Balb/C mice.,2023,10.1002/bab.2511,https://pubmed.ncbi.nlm.nih.gov/37694540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA19,ENSG00000166118,CTA,35774118,A Role of the TEX101 Interactome in the Common Aetiology Behind Male Subfertility and Testicular Germ Cell Tumor.,2022,10.3389/fonc.2022.892043,https://pubmed.ncbi.nlm.nih.gov/35774118/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA19,ENSG00000166118,CTA,28972294,Cancer/testis antigen SPATA19 is frequently expressed in benign prostatic hyperplasia and prostate cancer.,2017,10.1111/apm.12775,https://pubmed.ncbi.nlm.nih.gov/28972294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA19,ENSG00000166118,CTA,35403672,TBC1D21 is an essential factor for sperm mitochondrial sheath assembly and male fertility‡.,2022,10.1093/biolre/ioac069,https://pubmed.ncbi.nlm.nih.gov/35403672/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA19,ENSG00000166118,CTA,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA19,ENSG00000166118,CTA,33674260,MFN2 interacts with nuage-associated proteins and is essential for male germ cell development by controlling mRNA fate during spermatogenesis.,2021,10.1242/dev.196295,https://pubmed.ncbi.nlm.nih.gov/33674260/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA19,ENSG00000166118,CTA,31692026,Anticancer properties of green-synthesised zinc oxide nanoparticles using Hyssopus officinalis extract on prostate carcinoma cells and its effects on testicular damage and spermatogenesis in Balb/C mice.,2020,10.1111/and.13450,https://pubmed.ncbi.nlm.nih.gov/31692026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA19,ENSG00000166118,CTA,26464818,Upregulation of RHOXF2 and ODF4 Expression in Breast Cancer Tissues.,2015,10.22074/cellj.2015.8,https://pubmed.ncbi.nlm.nih.gov/26464818/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA19,ENSG00000166118,CTA,35484731,Comparative high-throughput analysis of sperm membrane proteins from crossbred bulls with contrasting fertility.,2022,10.1111/and.14451,https://pubmed.ncbi.nlm.nih.gov/35484731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA19,ENSG00000166118,CTA,28867149,Establishing the role of rare coding variants in known Parkinson's disease risk loci.,2017,10.1016/j.neurobiolaging.2017.07.009,https://pubmed.ncbi.nlm.nih.gov/28867149/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA19,ENSG00000166118,CTA,19886887,Elevated expression levels of testis-specific genes TEX101 and SPATA19 in basal cell carcinoma and their correlation with clinical and pathological features.,2010,10.1111/j.1365-2133.2009.09568.x,https://pubmed.ncbi.nlm.nih.gov/19886887/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA19,ENSG00000166118,CTA,20682177,"Expression of two testis-specific genes, SPATA19 and LEMD1, in prostate cancer.",2010,10.1016/j.arcmed.2010.04.003,https://pubmed.ncbi.nlm.nih.gov/20682177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA19,ENSG00000166118,CTA,23721730,"Titanium dioxide nanoparticle-induced testicular damage, spermatogenesis suppression, and gene expression alterations in male mice.",2013,10.1016/j.jhazmat.2013.04.046,https://pubmed.ncbi.nlm.nih.gov/23721730/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA19,ENSG00000166118,CTA,17360959,Factors maintaining normal sperm tail structure during epididymal maturation studied in Gopc-/- mice.,2007,10.1095/biolreprod.106.058735,https://pubmed.ncbi.nlm.nih.gov/17360959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA19,ENSG00000166118,CTA,12688595,"Isolation and expression analysis of the human testis-specific gene, SPERGEN-1, a spermatogenic cell-specific gene-1.",2003,10.1023/a:1021748310102,https://pubmed.ncbi.nlm.nih.gov/12688595/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA21,ENSG00000187144,CTA,36183486,Whole genome sequencing identifies candidate genes for familial essential tremor and reveals biological pathways implicated in essential tremor aetiology.,2022,10.1016/j.ebiom.2022.104290,https://pubmed.ncbi.nlm.nih.gov/36183486/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA21,ENSG00000187144,CTA,23205112,Whole-exome sequencing identifies mutated PCK2 and HUWE1 associated with carcinoma cell proliferation in a hepatocellular carcinoma patient.,2012,10.3892/ol.2012.825,https://pubmed.ncbi.nlm.nih.gov/23205112/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA21,ENSG00000187144,CTA,25811265,Investigation of the 53 Markers in a DNA-Based Prognostic Test Revealing New Predisposition Genes for Adolescent Idiopathic Scoliosis.,2015,10.1097/brs.0000000000000900,https://pubmed.ncbi.nlm.nih.gov/25811265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA3,ENSG00000173699,CTA,40641118,Roles of human SPATA3 in cell proliferation and expression pattern of &lt;i&gt;Spata3&lt;/i&gt; in mouse testis.,2025,10.3892/mmr.2025.13620,https://pubmed.ncbi.nlm.nih.gov/40641118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA3,ENSG00000173699,CTA,42789195,"Expression of long non‑coding RNAs DIAPH3‑AS1, HMMR‑AS1, and SPATA3‑AS1 in patients with colorectal cancer: association with chemotherapy response and clinicopathological features.",2026,10.1007/s11033-026-12789-5,https://pubmed.ncbi.nlm.nih.gov/42789195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA3,ENSG00000173699,CTA,33669425,Deletion of the Spata3 Gene Induces Sperm Alterations and In Vitro Hypofertility in Mice.,2021,10.3390/ijms22041959,https://pubmed.ncbi.nlm.nih.gov/33669425/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA3,ENSG00000173699,CTA,31006096,Characterization and molecular cloning of novel isoforms of human spermatogenesis associated gene SPATA3.,2019,10.1007/s11033-019-04825-4,https://pubmed.ncbi.nlm.nih.gov/31006096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA3,ENSG00000173699,CTA,36899892,miRNA Expression Profiles of Mouse Round Spermatids in GRTH/DDX25-Mediated Spermiogenesis: mRNA-miRNA Network Analysis.,2023,10.3390/cells12050756,https://pubmed.ncbi.nlm.nih.gov/36899892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA3,ENSG00000173699,CTA,34438721,Identification and Characterization of lncRNA and mRNA in Testes of Landrace and Hezuo Boars.,2021,10.3390/ani11082263,https://pubmed.ncbi.nlm.nih.gov/34438721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA3,ENSG00000173699,CTA,35709667,Mixed model-based eQTL analysis reveals lncRNAs associated with regulation of genes involved in sex determination and spermatogenesis: The key to understanding human gender imbalance.,2022,10.1016/j.compbiolchem.2022.107713,https://pubmed.ncbi.nlm.nih.gov/35709667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA3,ENSG00000173699,CTA,31748686,An exome-wide rare variant analysis of Korean men identifies three novel genes predisposing to prostate cancer.,2019,10.1038/s41598-019-53445-2,https://pubmed.ncbi.nlm.nih.gov/31748686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA3,ENSG00000173699,CTA,24012201,Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis.,2013,10.1016/j.fertnstert.2013.07.1999,https://pubmed.ncbi.nlm.nih.gov/24012201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA3,ENSG00000173699,CTA,12812072,[Molecular cloning for testis spermatogenesis cell apoptosis related gene TSARG1 and Mtsarg1 and expression analysis for Mtsarg1 gene].,2003,,https://pubmed.ncbi.nlm.nih.gov/12812072/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA3,ENSG00000173699,CTA,18551385,Molecular cloning and characterization of a novel transcript variant of Mtsarg1 gene.,2009,10.1007/s11033-008-9276-6,https://pubmed.ncbi.nlm.nih.gov/18551385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA3,ENSG00000173699,CTA,16147871,"Molecular cloning of a novel rat gene Tsarg1, a member of the DnaJ/HSP40 protein family.",2005,10.1080/10425170500129736,https://pubmed.ncbi.nlm.nih.gov/16147871/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA3,ENSG00000173699,CTA,28379507,Impact of male fertility status on the transcriptome of the bovine epididymis.,2017,10.1093/molehr/gax019,https://pubmed.ncbi.nlm.nih.gov/28379507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31A1,ENSG00000204849,CTA,29676996,Involvement of SPATA31 copy number variable genes in human lifespan.,2018,10.18632/aging.101421,https://pubmed.ncbi.nlm.nih.gov/29676996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31E1,ENSG00000177992,CTA,39677330,Identification of differentially expressed genes in human testis biopsies with defective spermatogenesis.,2024,10.1002/rmb2.12616,https://pubmed.ncbi.nlm.nih.gov/39677330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31E1,ENSG00000177992,CTA,38403804,Genetic profiling of azoospermic men to identify the etiology and predict reproductive potential.,2024,10.1007/s10815-024-03045-5,https://pubmed.ncbi.nlm.nih.gov/38403804/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31E1,ENSG00000177992,CTA,35709667,Mixed model-based eQTL analysis reveals lncRNAs associated with regulation of genes involved in sex determination and spermatogenesis: The key to understanding human gender imbalance.,2022,10.1016/j.compbiolchem.2022.107713,https://pubmed.ncbi.nlm.nih.gov/35709667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31E1,ENSG00000177992,CTA,36896575,The human sperm proteome-Toward a panel for male fertility testing.,2023,10.1111/andr.13431,https://pubmed.ncbi.nlm.nih.gov/36896575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31E1,ENSG00000177992,CTA,27079378,Screening of whole genome sequences identified high-impact variants for stallion fertility.,2016,10.1186/s12864-016-2608-3,https://pubmed.ncbi.nlm.nih.gov/27079378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31F1,ENSG00000205108,CTA,42116602,Comparative sperm proteomics in IVF patients with differential fertilization rates identifies FAM205A as a novel biomarker for male infertility.,2026,10.4103/aja202580,https://pubmed.ncbi.nlm.nih.gov/42116602/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31F1,ENSG00000205108,CTA,38916228,"Comparative Whole-Genome Sequencing Analysis of In-situ and Invasive Acral Lentiginous Melanoma: Markedly Increased Copy Number Gains of GAB2 , PAK1 , UCP2 , and CCND1 are Associated with Melanoma Invasion.",2024,10.1097/pas.0000000000002273,https://pubmed.ncbi.nlm.nih.gov/38916228/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31F1,ENSG00000205108,CTA,36456645,Development and validation of a novel immune-related prognostic signature in lung squamous cell carcinoma patients.,2022,10.1038/s41598-022-23140-w,https://pubmed.ncbi.nlm.nih.gov/36456645/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31F1,ENSG00000205108,CTA,37549510,Integrated molecular-network analysis reveals infertility-associated key genes and transcription factors in the non-obstructive azoospermia.,2023,10.1016/j.ejogrb.2023.07.023,https://pubmed.ncbi.nlm.nih.gov/37549510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31F1,ENSG00000205108,CTA,29930801,"Identification of nine genes as novel susceptibility loci for early-onset ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage.",2018,10.3892/br.2018.1104,https://pubmed.ncbi.nlm.nih.gov/29930801/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATS1,ENSG00000249481,CTA,35883403,Expression and Characterization of the Spats1 Gene and Its Response to E2/MT Treatment in the Chinese Soft-Shelled Turtle (Pelodiscus sinensis).,2022,10.3390/ani12141858,https://pubmed.ncbi.nlm.nih.gov/35883403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATS1,ENSG00000249481,CTA,37891374,Identification of hub genes associated with spermatogenesis by bioinformatics analysis.,2023,10.1038/s41598-023-45620-3,https://pubmed.ncbi.nlm.nih.gov/37891374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATS1,ENSG00000249481,CTA,33945571,"SPATS1 (spermatogenesis-associated, serine-rich 1) is not essential for spermatogenesis and fertility in mouse.",2021,10.1371/journal.pone.0251028,https://pubmed.ncbi.nlm.nih.gov/33945571/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATS1,ENSG00000249481,CTA,41751972,"Inflammation and Oxidative-Stress Pathways Are Associated with Idiopathic Sudden Hearing Loss: A Genome-Wide Association Study in 15,494 Japanese Individuals.",2026,10.3390/ijms27041836,https://pubmed.ncbi.nlm.nih.gov/41751972/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATS1,ENSG00000249481,CTA,32251302,Transcriptomic analysis of female and male gonads in juvenile snakeskin gourami (Trichopodus pectoralis).,2020,10.1038/s41598-020-61738-0,https://pubmed.ncbi.nlm.nih.gov/32251302/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATS1,ENSG00000249481,CTA,37913874,Comparative genomic survey and functional analysis of DKKL1 during spermatogenesis in the Chinese soft-shelled turtle (Pelodiscus sinensis).,2024,10.1016/j.ijbiomac.2023.127696,https://pubmed.ncbi.nlm.nih.gov/37913874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATS1,ENSG00000249481,CTA,19948251,Spats 1 (Srsp1) is differentially expressed during testis development of the rat.,2010,10.1016/j.gep.2009.11.006,https://pubmed.ncbi.nlm.nih.gov/19948251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATS1,ENSG00000249481,CTA,24012201,Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis.,2013,10.1016/j.fertnstert.2013.07.1999,https://pubmed.ncbi.nlm.nih.gov/24012201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYE4,ENSG00000183318,CTA,22763696,Evolution of the Cdk-activator Speedy/RINGO in vertebrates.,2012,10.1007/s00018-012-1050-1,https://pubmed.ncbi.nlm.nih.gov/22763696/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEM1,ENSG00000181323,CTA,40161258,Protective effects of corn silk and &lt;i&gt;asparagus Officinalis&lt;/i&gt; against formaldehyde-induced reproductive toxicity in male rats via CDK2/Spem1/Fbxo47 and Tet1 pathways.,2025,10.1093/toxres/tfaf039,https://pubmed.ncbi.nlm.nih.gov/40161258/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEM1,ENSG00000181323,CTA,40917356,Potential role of 4-hydroxyisoleucine in enhancing fertility in male mice with diet-induced obesity.,2025,10.3389/fendo.2025.1561543,https://pubmed.ncbi.nlm.nih.gov/40917356/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEM1,ENSG00000181323,CTA,41850444,Benzo[a]pyrene lowers the sperm quality in male rats by downregulating the expression of ZMYND15 and ZMYND10.,2026,10.1016/j.reprotox.2026.109225,https://pubmed.ncbi.nlm.nih.gov/41850444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEM1,ENSG00000181323,CTA,37118964,Differential Proteomic Analysis of Human Sperm: A Systematic Review to Identify Candidate Targets to Monitor Sperm Quality.,2024,10.5534/wjmh.220262,https://pubmed.ncbi.nlm.nih.gov/37118964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEM1,ENSG00000181323,CTA,35145544,Identification of Key Genes Related to Postnatal Testicular Development Based on Transcriptomic Data of Testis in Hu Sheep.,2021,10.3389/fgene.2021.773695,https://pubmed.ncbi.nlm.nih.gov/35145544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEM1,ENSG00000181323,CTA,37079096,Cryostress induces fragmentation and alters the abundance of sperm transcripts associated with fertilizing competence and reproductive processes in buffalo.,2023,10.1007/s00441-023-03764-8,https://pubmed.ncbi.nlm.nih.gov/37079096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEM1,ENSG00000181323,CTA,33623031,Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates.,2021,10.1038/s41467-021-21517-5,https://pubmed.ncbi.nlm.nih.gov/33623031/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEM1,ENSG00000181323,CTA,30054974,"Among seven testis-specific molecular markers, SPEM1 appears to have a significant clinical value for prediction of sperm retrieval in azoospermic men.",2018,10.1111/andr.12528,https://pubmed.ncbi.nlm.nih.gov/30054974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEM1,ENSG00000181323,CTA,33425888,Role of Phosphorylated Gonadotropin-Regulated Testicular RNA Helicase (GRTH/DDX25) in the Regulation of Germ Cell Specific mRNAs in Chromatoid Bodies During Spermatogenesis.,2020,10.3389/fcell.2020.580019,https://pubmed.ncbi.nlm.nih.gov/33425888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEM1,ENSG00000181323,CTA,21184802,RANBP17 is localized to the XY body of spermatocytes and interacts with SPEM1 on the manchette of elongating spermatids.,2011,10.1016/j.mce.2010.12.021,https://pubmed.ncbi.nlm.nih.gov/21184802/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEM1,ENSG00000181323,CTA,29305944,Expression of ZMYND15 in Testes of Azoospermic Men and Association With Sperm Retrieval.,2018,10.1016/j.urology.2017.12.023,https://pubmed.ncbi.nlm.nih.gov/29305944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEM1,ENSG00000181323,CTA,36896575,The human sperm proteome-Toward a panel for male fertility testing.,2023,10.1111/andr.13431,https://pubmed.ncbi.nlm.nih.gov/36896575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEM1,ENSG00000181323,CTA,20558241,UBQLN1 interacts with SPEM1 and participates in spermiogenesis.,2010,10.1016/j.mce.2010.06.006,https://pubmed.ncbi.nlm.nih.gov/20558241/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEM1,ENSG00000181323,CTA,17426145,"Lack of Spem1 causes aberrant cytoplasm removal, sperm deformation, and male infertility.",2007,10.1073/pnas.0701669104,https://pubmed.ncbi.nlm.nih.gov/17426145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEM1,ENSG00000181323,CTA,20675388,Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility.,2010,10.1074/jbc.m110.116418,https://pubmed.ncbi.nlm.nih.gov/20675388/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMAP2,ENSG00000105549,CTA,40137503,Oxidative and Molecular-Structural Alterations of Spermatozoa in Swine and Ram Exposed to the Triazole Ipconazole.,2025,10.3390/toxics13030176,https://pubmed.ncbi.nlm.nih.gov/40137503/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMAP2,ENSG00000105549,CTA,35173218,Using publicly available transcriptomic data to identify mechanistic and diagnostic biomarkers in azoospermia and overall male infertility.,2022,10.1038/s41598-022-06476-1,https://pubmed.ncbi.nlm.nih.gov/35173218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMAP2,ENSG00000105549,CTA,34567679,Wearable multi-sensing double-chain thermoelectric generator.,2020,10.1038/s41378-020-0179-6,https://pubmed.ncbi.nlm.nih.gov/34567679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMAP2,ENSG00000105549,CTA,30679029,Stage-specific testes proteomics of Drosophila melanogaster identifies essential proteins for male fertility.,2019,10.1016/j.ejcb.2019.01.001,https://pubmed.ncbi.nlm.nih.gov/30679029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMAP2,ENSG00000105549,CTA,25746199,Intersex related gene expression profiles in clams Scrobicularia plana: Molecular markers and environmental application.,2015,10.1016/j.marpolbul.2015.02.019,https://pubmed.ncbi.nlm.nih.gov/25746199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMAP2,ENSG00000105549,CTA,12748127,Male mice lacking the Theg (testicular haploid expressed gene) protein undergo normal spermatogenesis and are fertile.,2003,10.1095/biolreprod.103.017400,https://pubmed.ncbi.nlm.nih.gov/12748127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMAP2,ENSG00000105549,CTA,26824959,Colistin Resistance Caused by Inactivation of the MgrB Regulator Is Not Associated with Decreased Virulence of Sequence Type 258 KPC Carbapenemase-Producing Klebsiella pneumoniae.,2016,10.1128/aac.02981-15,https://pubmed.ncbi.nlm.nih.gov/26824959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMAP2,ENSG00000105549,CTA,26147511,The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Depression: A Meta-Analysis.,2015,10.1371/journal.pone.0132274,https://pubmed.ncbi.nlm.nih.gov/26147511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMAP2,ENSG00000105549,CTA,11173852,"Alternative splicing, chromosome assignment and subcellular localization of the testicular haploid expressed gene (THEG).",2000,10.1159/000056840,https://pubmed.ncbi.nlm.nih.gov/11173852/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMAP2,ENSG00000105549,CTA,10330110,A novel testicular haploid expressed gene (THEG) involved in mouse spermatid-sertoli cell interaction.,1999,10.1095/biolreprod60.6.1488,https://pubmed.ncbi.nlm.nih.gov/10330110/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMAP2,ENSG00000105549,CTA,10747865,Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis.,2000,10.1074/jbc.c901047199,https://pubmed.ncbi.nlm.nih.gov/10747865/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMAP2,ENSG00000105549,CTA,14740195,Enhanced secretion of Bacillus stearothermophilus L1 lipase in Saccharomyces cerevisiae by translational fusion to cellulose-binding domain.,2004,10.1007/s00253-003-1547-5,https://pubmed.ncbi.nlm.nih.gov/14740195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMAP2,ENSG00000105549,CTA,28304634,"[Autoradiographic study of the effect of temperature on cellular proliferation in late embryos ofPleurodeles waltlii Michah. (Amphibia, Urodela)].",1971,10.1007/bf00634064,https://pubmed.ncbi.nlm.nih.gov/28304634/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP10,ENSG00000196900,CTA,42174372,"TEX43, a testis-enriched microtubule-associated gene, exerts minimal impact on spermatogenesis and fertility in mice and humans.",2026,10.1007/s10815-026-03911-4,https://pubmed.ncbi.nlm.nih.gov/42174372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP10,ENSG00000196900,CTA,41118442,The core outer junction protein CFAP77 connects A- and B-tubules within doublet microtubules of cilia and flagella.,2025,10.1371/journal.pbio.3003442,https://pubmed.ncbi.nlm.nih.gov/41118442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP11,ENSG00000257987,CTA,42791710,Transcriptomic Dynamics and ECM Remodeling During Postnatal Testicular Maturation in the Tianzhu White Yak.,2026,10.3390/ani16182853,https://pubmed.ncbi.nlm.nih.gov/42791710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP11,ENSG00000257987,CTA,41550493,Normal spermatogenesis and fertility in &lt;i&gt;Spmip8&lt;/i&gt; deficiency male mice.,2026,10.1016/j.bbrep.2025.102406,https://pubmed.ncbi.nlm.nih.gov/41550493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP2,ENSG00000164123,CTA,41550493,Normal spermatogenesis and fertility in &lt;i&gt;Spmip8&lt;/i&gt; deficiency male mice.,2026,10.1016/j.bbrep.2025.102406,https://pubmed.ncbi.nlm.nih.gov/41550493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP2,ENSG00000164123,CTA,42563519,Systematic Reanalysis of Whole-Exome Sequencing in Genetically Unsolved Pediatric Primary Ciliary Dyskinesia.,2026,10.1002/ppul.71776,https://pubmed.ncbi.nlm.nih.gov/42563519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP2,ENSG00000164123,CTA,41667419,DNA methylation signatures associated with early-onset schizophrenia in Chinese patients.,2026,10.1038/s41398-026-03869-y,https://pubmed.ncbi.nlm.nih.gov/41667419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP2,ENSG00000164123,CTA,40572022,Mouse genome engineering uncovers 18 genes dispensable for male reproduction.,2026,10.1111/andr.70088,https://pubmed.ncbi.nlm.nih.gov/40572022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP9,ENSG00000172073,CTA,29563520,"The evolutionarily conserved genes: Tex37, Ccdc73, Prss55 and Nxt2 are dispensable for fertility in mice.",2018,10.1038/s41598-018-23176-x,https://pubmed.ncbi.nlm.nih.gov/29563520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP9,ENSG00000172073,CTA,35709667,Mixed model-based eQTL analysis reveals lncRNAs associated with regulation of genes involved in sex determination and spermatogenesis: The key to understanding human gender imbalance.,2022,10.1016/j.compbiolchem.2022.107713,https://pubmed.ncbi.nlm.nih.gov/35709667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP9,ENSG00000172073,CTA,33238277,Fertility Relevance Probability Analysis Shortlists Genetic Markers for Male Fertility Impairment.,2020,10.1159/000511117,https://pubmed.ncbi.nlm.nih.gov/33238277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP9,ENSG00000172073,CTA,17091336,"Identification and characteristics of a novel testis-specific gene, Tsc21, in mice and human.",2007,10.1007/s11033-006-9026-6,https://pubmed.ncbi.nlm.nih.gov/17091336/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP9,ENSG00000172073,CTA,26168773,Human Spermatozoa as a Model for Detecting Missing Proteins in the Context of the Chromosome-Centric Human Proteome Project.,2015,10.1021/acs.jproteome.5b00170,https://pubmed.ncbi.nlm.nih.gov/26168773/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,42854377,Meiotic recombination proteins in cancer.,2026,10.1016/j.dnarep.2026.103963,https://pubmed.ncbi.nlm.nih.gov/42854377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,42268970,Adaptive Spo11 RNA editing gate optimizes meiosis I pace and mitotic proliferation while preserving ascospore formation.,2026,10.1126/sciadv.adu7607,https://pubmed.ncbi.nlm.nih.gov/42268970/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,42814036,Controlling Meiotic Double-Strand Break Formation in Mice: A Web of Multivalent Protein-Protein Interactions.,2026,10.1002/bies.70190,https://pubmed.ncbi.nlm.nih.gov/42814036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,42538288,MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice.,2026,10.1101/gad.353693.126,https://pubmed.ncbi.nlm.nih.gov/42538288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,42054421,Cryptic sex in Leishmania depends on SPO11 paralogs.,2026,10.1371/journal.ppat.1014181,https://pubmed.ncbi.nlm.nih.gov/42054421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,42834443,Prepubertal exposure to SARS-CoV-2 single-stranded RNA disrupts spermatogenesis and causes intergenerational effects in mice.,2026,10.1093/molehr/gaag059,https://pubmed.ncbi.nlm.nih.gov/42834443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,42489337,Repair and misrepair of telomeric DNA in dynamic interactions with PML nuclear bodies and lamin B1 in doxorubicin-treated cancer cells.,2026,10.1080/19491034.2026.2688655,https://pubmed.ncbi.nlm.nih.gov/42489337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,41972556,The Molecular Characterization and Functional Analysis of &lt;i&gt;Pomacea canaliculata&lt;/i&gt; Boule: A Central Player in Spermatogenesis and Male Fertility.,2026,10.3390/biology15070554,https://pubmed.ncbi.nlm.nih.gov/41972556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,42011758,Mei4 deficiency induces sexual dimorphism in early meiosis and promotes production of unreduced eggs in zebrafish.,2026,10.24272/j.issn.2095-8137.2025.186,https://pubmed.ncbi.nlm.nih.gov/42011758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,39142066,"Elevated temperature affects the expression of signaling molecules in quail testes meiosis I prophase, but spermatogenesis remains normal.",2024,10.1016/j.theriogenology.2024.08.012,https://pubmed.ncbi.nlm.nih.gov/39142066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,42453559,Mapping Meiotic Recombination DNA Double-Strand Breaks (DSBs) Hotspots -Methodological Advances and Challenges.,2026,10.1002/ggn2.202500019,https://pubmed.ncbi.nlm.nih.gov/42453559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,40787865,[NSD1 regulates H3K36me2 in the pathogenesis of non-obstructive azoospermia].,2025,,https://pubmed.ncbi.nlm.nih.gov/40787865/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,42626841,Insights into the recruitment of the H3K4me3 reader Spp1 by the meiotic double-strand break protein Mer2.,2026,10.1093/nar/gkag785,https://pubmed.ncbi.nlm.nih.gov/42626841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,42121777,Stage-Specific Transcriptomic Analysis Reveals Molecular Basis of Ovarian Sterility in Triploid Turbot (&lt;i&gt;Scophthalmus maximus&lt;/i&gt;).,2026,10.3390/ani16091357,https://pubmed.ncbi.nlm.nih.gov/42121777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,42836123,Adolescent psychological stress impairs spermatogenesis by disrupting meiotic progression in male mice.,2026,10.7717/peerj.21750,https://pubmed.ncbi.nlm.nih.gov/42836123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,37682311,The proper interplay between the expression of Spo11 splice isoforms and the structure of the pseudoautosomal region promotes XY chromosomes recombination.,2023,10.1007/s00018-023-04912-7,https://pubmed.ncbi.nlm.nih.gov/37682311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,39932629,Genetic insights into non-obstructive azoospermia: Implications for diagnosis and TESE outcomes.,2025,10.1007/s10815-025-03409-5,https://pubmed.ncbi.nlm.nih.gov/39932629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,39972129,Reconstitution of SPO11-dependent double-strand break formation.,2025,10.1038/s41586-025-08601-2,https://pubmed.ncbi.nlm.nih.gov/39972129/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,40181639,Spo11: from topoisomerase VI to meiotic recombination initiator.,2025,10.1042/bst20253019,https://pubmed.ncbi.nlm.nih.gov/40181639/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,42886774,Suppression of meiotic double-strand break formation in somatic cells by DREAM factors TCX5/6 maintains genome stability.,2026,10.1126/sciadv.aef7208,https://pubmed.ncbi.nlm.nih.gov/42886774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,40207630,Light-controlled Spo11-less meiotic DNA breaks by MagTAQing lead to chromosomal aberrations.,2025,10.1093/nar/gkaf206,https://pubmed.ncbi.nlm.nih.gov/40207630/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,39021337,DNA cytosine methyltransferases differentially regulate genome-wide hypermutation and interhomolog recombination in Trichoderma reesei meiosis.,2024,10.1093/nar/gkae611,https://pubmed.ncbi.nlm.nih.gov/39021337/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,35857772,Differentiated function and localisation of SPO11-1 and PRD3 on the chromosome axis during meiotic DSB formation in Arabidopsis thaliana.,2022,10.1371/journal.pgen.1010298,https://pubmed.ncbi.nlm.nih.gov/35857772/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,36635291,Genetic conversion of a split-drive into a full-drive element.,2023,10.1038/s41467-022-35044-4,https://pubmed.ncbi.nlm.nih.gov/36635291/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,33322957,Long-term exposure to formaldehyde induced down-regulation of SPO11 in rats.,2021,10.1080/08958378.2020.1859652,https://pubmed.ncbi.nlm.nih.gov/33322957/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,35580048,Chromosomal synapsis defects can trigger oocyte apoptosis without elevating numbers of persistent DNA breaks above wild-type levels.,2022,10.1093/nar/gkac355,https://pubmed.ncbi.nlm.nih.gov/35580048/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,38619421,Mouse models to explore the biological and organismic role of DNA polymerase beta.,2024,10.1002/em.22593,https://pubmed.ncbi.nlm.nih.gov/38619421/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,34951404,Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation.,2021,10.7554/elife.72330,https://pubmed.ncbi.nlm.nih.gov/34951404/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,36816926,Construction of a DDR-related signature for predicting of prognosis in metastatic colorectal carcinoma.,2023,10.3389/fonc.2023.1043160,https://pubmed.ncbi.nlm.nih.gov/36816926/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,33674604,Inherently confinable split-drive systems in Drosophila.,2021,10.1038/s41467-021-21771-7,https://pubmed.ncbi.nlm.nih.gov/33674604/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,34458909,Conservation and divergence of meiotic DNA double strand break forming mechanisms in Arabidopsis thaliana.,2021,10.1093/nar/gkab715,https://pubmed.ncbi.nlm.nih.gov/34458909/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,35052491,Changes in Expression of Specific mRNA Transcripts after Single- or Re-Irradiation in Mouse Testes.,2022,10.3390/genes13010151,https://pubmed.ncbi.nlm.nih.gov/35052491/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,24850846,Ectopic expression of cancer-testis antigens in cutaneous T-cell lymphoma patients.,2014,10.1158/1078-0432.ccr-14-0307,https://pubmed.ncbi.nlm.nih.gov/24850846/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,34599968,Loss of TDP-43 in male germ cells causes meiotic failure and impairs fertility in mice.,2021,10.1016/j.jbc.2021.101231,https://pubmed.ncbi.nlm.nih.gov/34599968/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,27821479,Functional Roles of Acetylated Histone Marks at Mouse Meiotic Recombination Hot Spots.,2017,10.1128/mcb.00942-15,https://pubmed.ncbi.nlm.nih.gov/27821479/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,34359134,Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profiles in Testes of Calves and Sexually Mature Wandong Bulls (Bos taurus).,2021,10.3390/ani11072006,https://pubmed.ncbi.nlm.nih.gov/34359134/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,31649282,A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome.,2019,10.1038/s41467-019-12802-5,https://pubmed.ncbi.nlm.nih.gov/31649282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPO11,ENSG00000054796,CTA,10622720,Differential gene expression of mammalian SPO11/TOP6A homologs during meiosis.,1999,10.1016/s0014-5793(99)01546-x,https://pubmed.ncbi.nlm.nih.gov/10622720/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,39460794,Selective regulation of aspartyl intramembrane protease activity by calnexin.,2024,10.1007/s00018-024-05478-8,https://pubmed.ncbi.nlm.nih.gov/39460794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,39823331,Genome-wide and phenome-wide studies provided insights into brain glymphatic system function and its clinical associations.,2025,10.1126/sciadv.adr4606,https://pubmed.ncbi.nlm.nih.gov/39823331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,40307375,The N-terminal PA domains of signal-peptide-peptidase-like 2 (SPPL2) proteases impact on TNFα cleavage.,2025,10.1038/s42003-025-08102-y,https://pubmed.ncbi.nlm.nih.gov/40307375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,30733280,The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.,2019,10.15252/embr.201846449,https://pubmed.ncbi.nlm.nih.gov/30733280/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,36066346,A specific role for importin-5 and NASP in the import and nuclear hand-off of monomeric H3.,2022,10.7554/elife.81755,https://pubmed.ncbi.nlm.nih.gov/36066346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,37261541,The transmembrane domain of Frey1 harbors a transplantable inhibitory motif for intramembrane proteases.,2023,10.1007/s00018-023-04823-7,https://pubmed.ncbi.nlm.nih.gov/37261541/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,30733281,Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins.,2019,10.15252/embr.201846451,https://pubmed.ncbi.nlm.nih.gov/30733281/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,38769620,Association of Gene Expression and Tremor Network Structure.,2024,10.1002/mds.29831,https://pubmed.ncbi.nlm.nih.gov/38769620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,39910297,Multi-interface licensing of protein import into a phage nucleus.,2025,10.1038/s41586-024-08547-x,https://pubmed.ncbi.nlm.nih.gov/39910297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,38254936,MAPT Locus in Parkinson's Disease Patients of Ashkenazi Origin: A Stratified Analysis.,2023,10.3390/genes15010046,https://pubmed.ncbi.nlm.nih.gov/38254936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,33637690,Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer's disease.,2021,10.1038/s41398-021-01263-4,https://pubmed.ncbi.nlm.nih.gov/33637690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,34250827,Outcomes of systemic anticoagulation with bivalirudin for Impella 5.0.,2021,10.1177/03913988211032238,https://pubmed.ncbi.nlm.nih.gov/34250827/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,32052089,Physiological functions of SPP/SPPL intramembrane proteases.,2020,10.1007/s00018-020-03470-6,https://pubmed.ncbi.nlm.nih.gov/32052089/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,37761960,Identification of Breast Cancer Metastasis Markers from Gene Expression Profiles Using Machine Learning Approaches.,2023,10.3390/genes14091820,https://pubmed.ncbi.nlm.nih.gov/37761960/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,32561905,CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity.,2020,10.1093/biolre/ioaa084,https://pubmed.ncbi.nlm.nih.gov/32561905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,34674882,Alterations in the Nucleocytoplasmic Transport in Heart Transplant Rejection.,2021,10.1016/j.transproceed.2021.09.003,https://pubmed.ncbi.nlm.nih.gov/34674882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,33381526,Signaling Functions of Intramembrane Aspartyl-Proteases.,2020,10.3389/fcvm.2020.591787,https://pubmed.ncbi.nlm.nih.gov/33381526/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,36047592,The intramembrane proteases SPPL2a and SPPL2b regulate the homeostasis of selected SNARE proteins.,2023,10.1111/febs.16610,https://pubmed.ncbi.nlm.nih.gov/36047592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,32829096,Screening non-MAPT genes of the Chr17q21 H1 haplotype in Parkinson's disease.,2020,10.1016/j.parkreldis.2020.07.022,https://pubmed.ncbi.nlm.nih.gov/32829096/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,36271639,Outcomes of systemic bivalirudin and sodium bicarbonate purge solution for Impella 5.5.,2023,10.1111/aor.14428,https://pubmed.ncbi.nlm.nih.gov/36271639/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,36764431,The influence of ZnO nanoparticles on horizontal transfer of resistance genes in lab and soil conditions.,2023,10.1016/j.envres.2023.115420,https://pubmed.ncbi.nlm.nih.gov/36764431/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,23075911,"Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.",2013,10.1159/000341715,https://pubmed.ncbi.nlm.nih.gov/23075911/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,24429156,Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.,2013,10.1016/s2213-2600(13)70045-6,https://pubmed.ncbi.nlm.nih.gov/24429156/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPPL2C,ENSG00000185294,CTA,19259881,"Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death.",2009,10.1080/10715760902736283,https://pubmed.ncbi.nlm.nih.gov/19259881/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,42711398,N-terminal thrombospondin-1 enhances muscle function and tissue-specific metabolic adaptation in response to exercise and cold exposure.,2026,10.1038/s12276-026-01830-z,https://pubmed.ncbi.nlm.nih.gov/42711398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,42557768,ADAMTS4 mediates LPS-induced cardiac injury and myocardial fibrosis through proteolytic cleavage of TSP1.,2026,10.1002/ctm2.70769,https://pubmed.ncbi.nlm.nih.gov/42557768/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,41554713,Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization.,2026,10.1038/s41413-025-00493-2,https://pubmed.ncbi.nlm.nih.gov/41554713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,41197678,Thrombospondin-1 regulates synaptic transmission in hippocampal field CA2 and social behavior in mice.,2025,10.1016/j.nbd.2025.107176,https://pubmed.ncbi.nlm.nih.gov/41197678/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,41533912,CGRP/TSP1 Signaling Dampens Corneal Inflammation and Fibrosis by Targeting A2M During Corneal Stromal Wound Healing.,2026,10.1167/iovs.67.1.10,https://pubmed.ncbi.nlm.nih.gov/41533912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,41594624,Phosphomimetic Thrombospondin-1 Modulates Integrin β1-FAK Signaling and Vascular Cell Functions.,2026,10.3390/biom16010084,https://pubmed.ncbi.nlm.nih.gov/41594624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,41021282,TNAP-induced CD47 membrane expression enhances TGF-β1 conversion in liver fibrosis.,2025,10.1097/hc9.0000000000000781,https://pubmed.ncbi.nlm.nih.gov/41021282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,39440046,Induction of interleukin-6 by SPZ1-mediated Wnt5a signaling boosts progression of nasopharyngeal carcinoma cells.,2024,10.7150/jca.99648,https://pubmed.ncbi.nlm.nih.gov/39440046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,42778431,Circulating angiogenic and inflammatory biomarkers profiling in patients with hereditary hemorrhagic telangiectasia.,2026,10.1016/j.ejim.2026.107200,https://pubmed.ncbi.nlm.nih.gov/42778431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,41319285,Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive-Like Behaviors.,2026,10.1002/advs.202510780,https://pubmed.ncbi.nlm.nih.gov/41319285/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,41596404,Thrombospondin 1-CD47 Signalling Modulates Vascular Smooth Muscle Cell Senescence in Chronic Kidney Disease.,2026,10.3390/ijms27020755,https://pubmed.ncbi.nlm.nih.gov/41596404/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,41252281,Cell-dependent contributions of thrombospondin-1 to the rupture of abdominal aortic aneurysm in mice.,2026,10.1093/cvr/cvaf243,https://pubmed.ncbi.nlm.nih.gov/41252281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,42271307,Plasma proteomic profiling uncovers the age-related molecular changes in chronic obstructive pulmonary disease.,2026,10.1186/s12890-026-04396-8,https://pubmed.ncbi.nlm.nih.gov/42271307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,41128612,Fibulin-7 in progenitor cells promotes adipose tissue fibrosis and disrupts metabolic homeostasis in obesity.,2026,10.1093/procel/pwaf084,https://pubmed.ncbi.nlm.nih.gov/41128612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,41303525,Targeting the CD47-TSP1 Axis in Abdominal Aortic Aneurysm: A Novel Immunotherapeutic Approach.,2025,10.3390/ijms262211042,https://pubmed.ncbi.nlm.nih.gov/41303525/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,41514867,"Hyperglycemia Modulates the Expression of MAPK13, TSP1, and CXCR2 During Wound Healing in Sprague Dawley Rats.",2025,10.3390/biology15010026,https://pubmed.ncbi.nlm.nih.gov/41514867/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,41523759,Clinical significance of differential plasma proteins levels in the diagnosis of epithelial ovarian cancer.,2025,10.5493/wjem.v15.i3.107711,https://pubmed.ncbi.nlm.nih.gov/41523759/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,40404658,Glioma-neuronal circuit remodeling induces regional immunosuppression.,2025,10.1038/s41467-025-60074-z,https://pubmed.ncbi.nlm.nih.gov/40404658/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,41820365,Megakaryocyte and platelet thrombospondin-1 regulates matrix remodeling by stabilizing basement membrane COL6A1 in lung injury.,2026,10.1038/s41467-026-70489-x,https://pubmed.ncbi.nlm.nih.gov/41820365/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,42726120,Genomic and Structural Analysis of Gamete Recognition Proteins in a Broadcast Spawning Echinoderm Mesocentrotus franciscanus.,2026,10.1007/s00239-026-10346-z,https://pubmed.ncbi.nlm.nih.gov/42726120/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,36418073,Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response.,2022,10.1136/jitc-2022-004712,https://pubmed.ncbi.nlm.nih.gov/36418073/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,40111290,Urine Measurements of the Renin-Angiotensin System-Regulated Proteins Predict Death and Graft Loss in Kidney Transplant Recipients Enrolled in a Ramipril versus Placebo Randomized Controlled Trial.,2025,10.1021/acs.jproteome.4c01100,https://pubmed.ncbi.nlm.nih.gov/40111290/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,37217603,The TSP1-CD47-SIRPα interactome: an immune triangle for the checkpoint era.,2023,10.1007/s00262-023-03465-9,https://pubmed.ncbi.nlm.nih.gov/37217603/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,38339122,PP2A Affects Angiogenesis via Its Interaction with a Novel Phosphorylation Site of TSP1.,2024,10.3390/ijms25031844,https://pubmed.ncbi.nlm.nih.gov/38339122/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,41558567,Topical cream loaded with upcycled citrus bioactive chitosan-pectin nanoparticle protects skin from UV-induced photoaging.,2026,10.1016/j.ijbiomac.2026.150374,https://pubmed.ncbi.nlm.nih.gov/41558567/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,41140164,Interplay Between Thrombospondin-1 and CD36 Modulates Platelet-RBC Interaction in Thrombosis and Abdominal Aneurysm Formation.,2025,10.1161/circresaha.125.326701,https://pubmed.ncbi.nlm.nih.gov/41140164/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,37831763,Thrombospondin-1 proteomimetic polymers exhibit anti-angiogenic activity in a neovascular age-related macular degeneration mouse model.,2023,10.1126/sciadv.adi8534,https://pubmed.ncbi.nlm.nih.gov/37831763/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,42118850,DGAT1 Drives Racially Divergent Fibroblast Activation via ERK1/2-Dependent Tumorigenic Signaling in Prostate Cancer.,2026,10.1158/2767-9764.crc-25-0701,https://pubmed.ncbi.nlm.nih.gov/42118850/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,41513664,Endothelial IRE1α promotes thrombospondin-1 mRNA decay and supports metabolic stress adaptation of pancreatic islets.,2026,10.1038/s41467-025-68276-1,https://pubmed.ncbi.nlm.nih.gov/41513664/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,34439212,Thrombospondin-1 Silencing Improves Lymphocyte Infiltration in Tumors and Response to Anti-PD-1 in Triple-Negative Breast Cancer.,2021,10.3390/cancers13164059,https://pubmed.ncbi.nlm.nih.gov/34439212/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,40596177,Hypoxia preconditioned plasma increases the expression of growth factors to accelerate diabetic wound healing by promoting angiogenesis.,2025,10.1038/s41598-025-04665-2,https://pubmed.ncbi.nlm.nih.gov/40596177/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,38412778,Skin-derived precursor conditioned medium alleviated photoaging via early activation of TGF-β/Smad signaling pathway by thrombospondin1: In vitro and in vivo studies.,2024,10.1016/j.jphotobiol.2024.112873,https://pubmed.ncbi.nlm.nih.gov/38412778/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,38037074,Inhibitory receptor CD47 binding to plasma TSP1 suppresses NK-cell IFN-γ production via activating the JAK/STAT3 pathway during HIV infection.,2023,10.1186/s12967-023-04667-6,https://pubmed.ncbi.nlm.nih.gov/38037074/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,34927311,Thrombospondin-1 induced programmed death-ligand 1-mediated immunosuppression by activating the STAT3 pathway in osteosarcoma.,2022,10.1111/cas.15237,https://pubmed.ncbi.nlm.nih.gov/34927311/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,15899793,"bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis.",2005,10.1158/0008-5472.can-04-3658,https://pubmed.ncbi.nlm.nih.gov/15899793/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPZ1,ENSG00000164299,CTA,12778315,Expression of a novel bHLH-Zip gene in human testis.,2003,,https://pubmed.ncbi.nlm.nih.gov/12778315/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSMEM1,ENSG00000165120,CTA,42658018,Integration of Proteomics and Phenomics to Reveal Molecular Differences in High and Low Semen Quality in Donkeys.,2026,10.1111/rda.70314,https://pubmed.ncbi.nlm.nih.gov/42658018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSMEM1,ENSG00000165120,CTA,41851414,Distinct adaptation and ancestral retention signals in African and European indigenous cattle genomes.,2026,10.1038/s42003-026-09856-9,https://pubmed.ncbi.nlm.nih.gov/41851414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSMEM1,ENSG00000165120,CTA,32301969,Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male mice†.,2020,10.1093/biolre/ioaa040,https://pubmed.ncbi.nlm.nih.gov/32301969/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSMEM1,ENSG00000165120,CTA,37782577,"Bull Sperm SWATH-MS-Based Proteomics Reveals Link between High Fertility and Energy Production, Motility Structures, and Sperm-Oocyte Interaction.",2023,10.1021/acs.jproteome.3c00461,https://pubmed.ncbi.nlm.nih.gov/37782577/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,42467186,"Identification of novel variants in SSX1, CPNE1, and SPTBN5 in men with oligoasthenoteratozoospermia using whole-genome sequencing.",2026,10.1007/s13353-026-01089-0,https://pubmed.ncbi.nlm.nih.gov/42467186/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,42192525,MicroRNA-29b-5p regulates cell proliferation and cancer stemness via TGF-β/p300 pathway in human synovial sarcoma.,2026,10.1186/s12935-026-04348-6,https://pubmed.ncbi.nlm.nih.gov/42192525/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,42030005,SSX1 and TRIM58 expression stratifies lung squamous cell carcinoma by tumor immune microenvironment characteristics and informs potential immunotherapy responsiveness.,2026,10.1007/s12094-026-04365-x,https://pubmed.ncbi.nlm.nih.gov/42030005/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,42294281,Case Report: Synovial sarcoma with diffuse myxoid stroma and complete absence of epithelial differentiation in the extremity.,2026,10.3389/fonc.2026.1846272,https://pubmed.ncbi.nlm.nih.gov/42294281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,41824139,Molecularly Variant Synovial Sarcoma of the Lower Lip: MN1::SSX1 Fusion as a Diagnostic Pitfall in the Head and Neck.,2026,10.1007/s12105-026-01902-6,https://pubmed.ncbi.nlm.nih.gov/41824139/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,42084470,Synovial Sarcoma With BRAF V600E Mutation: A Case Report and Literature Review.,2026,10.1002/gcc.70128,https://pubmed.ncbi.nlm.nih.gov/42084470/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,36796361,Deficiency of primate-specific SSX1 induced asthenoteratozoospermia in infertile men and cynomolgus monkey and tree shrew models.,2023,10.1016/j.ajhg.2023.01.016,https://pubmed.ncbi.nlm.nih.gov/36796361/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,37241221,Higher Expression Levels of SSX1 and SSX2 in Patients with Colon Cancer: Regulated In Vitro by the Inhibition of Methylation and Histone Deacetylation.,2023,10.3390/medicina59050988,https://pubmed.ncbi.nlm.nih.gov/37241221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,41982499,Primary Cardiac Synovial Sarcoma (PCSS): Clinicopathologic Features of 6 Cases and Literature Comparison.,2026,10.1155/crp/5272035,https://pubmed.ncbi.nlm.nih.gov/41982499/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,41149817,Molecular Profiling of &lt;i&gt;SYT-SSX&lt;/i&gt; Fusion Transcripts for Enhanced Diagnosis of Synovial Sarcomas.,2025,10.3390/jpm15100455,https://pubmed.ncbi.nlm.nih.gov/41149817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,40542346,"Overexpression of oncogenic polo-like kinase 1 disrupts the invasiveness, cell cycle, and apoptosis in synovial sarcoma.",2025,10.1186/s12967-025-06740-8,https://pubmed.ncbi.nlm.nih.gov/40542346/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,40307043,[A remarkable advancement in structural biology aimed at elucidating the ‍mechanism of synovial sarcoma development].,2025,10.1254/fpj.25013,https://pubmed.ncbi.nlm.nih.gov/40307043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,38273165,Identification of a DLG3 stop mutation in the MRX20 family.,2024,10.1038/s41431-024-01537-7,https://pubmed.ncbi.nlm.nih.gov/38273165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,39468035,Condensate remodeling reorganizes innate SS18 in synovial sarcomagenesis.,2024,10.1038/s41389-024-00539-w,https://pubmed.ncbi.nlm.nih.gov/39468035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,42687804,Renal Synovial Sarcoma Revisited: Clinicopathologic and Molecular Insights From 70 Cases With Report of a Rare SS18::NEDD4 Fusion.,2026,10.1097/pas.0000000000002610,https://pubmed.ncbi.nlm.nih.gov/42687804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,42653206,Next-Generation Sequencing Refines Diagnosis and Expands Precision Medicine Opportunities in Soft Tissue Sarcomas.,2026,10.3390/ijms27167201,https://pubmed.ncbi.nlm.nih.gov/42653206/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,42330401,[Penis synovial sarcoma: a rare case report].,2026,,https://pubmed.ncbi.nlm.nih.gov/42330401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,42553211,Rapid metastatic progression of primary pulmonary synovial sarcoma despite guideline-concordant multimodal therapy: a case report.,2026,10.3389/fonc.2026.1873338,https://pubmed.ncbi.nlm.nih.gov/42553211/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,42720542,"Neuroendocrine Differentiation in Synovial Sarcoma-An Immunohistochemical Study of 357 Tumors With 4 Markers: Chromogranin A, Synaptophysin, Insulinoma-associated Protein 1 and Insulin Gene Enhancer Protein ISL-1.",2026,10.1097/pai.0000000000001353,https://pubmed.ncbi.nlm.nih.gov/42720542/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,37056382,The inhibitory effect of KIAA1456 on the proliferation and metastasis of epithelial ovarian cancer through SSX1 and AKT signaling pathway.,2023,10.7150/jca.81587,https://pubmed.ncbi.nlm.nih.gov/37056382/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,37964984,Establishing and Validating an Aging-Related Prognostic Signature in Osteosarcoma.,2023,10.1155/2023/6245160,https://pubmed.ncbi.nlm.nih.gov/37964984/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,36950598,Gene-based cancer-testis antigens as prognostic indicators in hepatocellular carcinoma.,2023,10.1016/j.heliyon.2023.e13269,https://pubmed.ncbi.nlm.nih.gov/36950598/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,34555727,Effectiveness of 4-1BB-costimulated HER2-targeted chimeric antigen receptor T cell therapy for synovial sarcoma.,2021,10.1016/j.tranon.2021.101227,https://pubmed.ncbi.nlm.nih.gov/34555727/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,34504309,Identification of novel SSX1 fusions in synovial sarcoma.,2022,10.1038/s41379-021-00910-x,https://pubmed.ncbi.nlm.nih.gov/34504309/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,40416104,Epithelial-Predominant Synovial Sarcoma With a Deceptive Neuroendocrine Phenotype.,2025,10.7759/cureus.82988,https://pubmed.ncbi.nlm.nih.gov/40416104/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,36649303,Immune-related pan-cancer gene expression signatures of patient survival revealed by NanoString-based analyses.,2023,10.1371/journal.pone.0280364,https://pubmed.ncbi.nlm.nih.gov/36649303/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,27294163,"Adjuvant Autologous Melanoma Vaccine for Macroscopic Stage III Disease: Survival, Biomarkers, and Improved Response to CTLA-4 Blockade.",2016,10.1155/2016/8121985,https://pubmed.ncbi.nlm.nih.gov/27294163/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,34177903,A Novel Immune-Related Seventeen-Gene Signature for Predicting Early Stage Lung Squamous Cell Carcinoma Prognosis.,2021,10.3389/fimmu.2021.665407,https://pubmed.ncbi.nlm.nih.gov/34177903/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,38089873,Development of an autoantibody panel for early detection of lung cancer in the Chinese population.,2023,10.3389/fmed.2023.1209747,https://pubmed.ncbi.nlm.nih.gov/38089873/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,32019274,Cooperation between SS18-SSX1 and miR-214 in Synovial Sarcoma Development and Progression.,2020,10.3390/cancers12020324,https://pubmed.ncbi.nlm.nih.gov/32019274/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,31970591,Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies.,2019,10.1007/s10555-019-09839-9,https://pubmed.ncbi.nlm.nih.gov/31970591/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,29707408,A De Novo Xp11.23 Duplication in a Girl with a Severe Phenotype: Expanding the Clinical Spectrum.,2018,10.1055/s-0037-1612598,https://pubmed.ncbi.nlm.nih.gov/29707408/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,30615012,Expression of cancer/testis antigens in cutaneous melanoma: a systematic review.,2019,10.1097/cmr.0000000000000569,https://pubmed.ncbi.nlm.nih.gov/30615012/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,34022967,Research models and mesenchymal/epithelial plasticity of osteosarcoma.,2021,10.1186/s13578-021-00600-w,https://pubmed.ncbi.nlm.nih.gov/34022967/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX1,ENSG00000126752,CTA,7539744,"Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma.",1995,10.1002/j.1460-2075.1995.tb07228.x,https://pubmed.ncbi.nlm.nih.gov/7539744/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
SSX2,ENSG00000241476,CTA,42883856,Distinct and Convergent Roles of the Synovial Sarcoma X Breakpoint Family of Cancer-Testis Antigens in Ovarian Cancer.,2026,10.3390/ijms27198608,https://pubmed.ncbi.nlm.nih.gov/42883856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,42037201,"Correction to ""Ectopic expression of cancer/testis antigen SSX2 induces DNA damage and promotes genomic instability"".",2026,10.1002/1878-0261.70253,https://pubmed.ncbi.nlm.nih.gov/42037201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,42254925,Case Report: A case of primary renal synovial sarcoma.,2026,10.3389/fsurg.2026.1843112,https://pubmed.ncbi.nlm.nih.gov/42254925/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,37241221,Higher Expression Levels of SSX1 and SSX2 in Patients with Colon Cancer: Regulated In Vitro by the Inhibition of Methylation and Histone Deacetylation.,2023,10.3390/medicina59050988,https://pubmed.ncbi.nlm.nih.gov/37241221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,41149817,Molecular Profiling of &lt;i&gt;SYT-SSX&lt;/i&gt; Fusion Transcripts for Enhanced Diagnosis of Synovial Sarcomas.,2025,10.3390/jpm15100455,https://pubmed.ncbi.nlm.nih.gov/41149817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,41929439,Fulminant growth of primary pericardial synovial sarcoma despite partial resection: a case report.,2026,10.1093/ehjcr/ytag188,https://pubmed.ncbi.nlm.nih.gov/41929439/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,42687804,Renal Synovial Sarcoma Revisited: Clinicopathologic and Molecular Insights From 70 Cases With Report of a Rare SS18::NEDD4 Fusion.,2026,10.1097/pas.0000000000002610,https://pubmed.ncbi.nlm.nih.gov/42687804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,42553211,Rapid metastatic progression of primary pulmonary synovial sarcoma despite guideline-concordant multimodal therapy: a case report.,2026,10.3389/fonc.2026.1873338,https://pubmed.ncbi.nlm.nih.gov/42553211/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,41482561,Autologous multiantigen-targeted T cell therapy for pancreatic cancer: a phase 1/2 trial.,2026,10.1038/s41591-025-04043-5,https://pubmed.ncbi.nlm.nih.gov/41482561/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,42720542,"Neuroendocrine Differentiation in Synovial Sarcoma-An Immunohistochemical Study of 357 Tumors With 4 Markers: Chromogranin A, Synaptophysin, Insulinoma-associated Protein 1 and Insulin Gene Enhancer Protein ISL-1.",2026,10.1097/pai.0000000000001353,https://pubmed.ncbi.nlm.nih.gov/42720542/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,39206277,Nine Human Leukocyte Antigen (HLA) Class I Alleles are Omnipotent Against 11 Antigens Expressed in Melanoma Tumors.,2024,10.1177/11769351241274160,https://pubmed.ncbi.nlm.nih.gov/39206277/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,41174561,Hypoxia-driven metastatic progression in synovial sarcoma: insights from SYO-1 and SW982 models.,2025,10.1186/s12885-025-15125-5,https://pubmed.ncbi.nlm.nih.gov/41174561/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,40128131,SS18-SSX and SSX c-terminus antibodies for identification of specific fusion oncoprotein in mesenchymal neoplasms.,2025,10.1016/j.pathol.2024.11.013,https://pubmed.ncbi.nlm.nih.gov/40128131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,34729377,Novel TCR-like CAR-T cells targeting an HLA∗0201-restricted SSX2 epitope display strong activity against acute myeloid leukemia.,2021,10.1016/j.omtm.2021.09.008,https://pubmed.ncbi.nlm.nih.gov/34729377/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,32701706,Differential Expression of Cancer Testis Antigens on Lentigo Maligna and Lentigo Maligna Melanoma.,2020,10.1097/dad.0000000000001607,https://pubmed.ncbi.nlm.nih.gov/32701706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,41139024,Expanding the Clinicopathologic Spectrum of EWSR1::SSX-Rearranged Sarcomas: Series of 11 Cases Including Osteosarcomas and a Novel EWSR1::SSX4 Fusion.,2026,10.1016/j.modpat.2025.100922,https://pubmed.ncbi.nlm.nih.gov/41139024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,35430758,Cancer testis antigen (PRAME) as an independent marker for survival in oral squamous cell carcinoma (OSCC).,2022,10.1111/jop.13300,https://pubmed.ncbi.nlm.nih.gov/35430758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,38371523,"Designing, cloning and simulation studies of cancer/testis antigens based multi-epitope vaccine candidates against cutaneous melanoma: An immunoinformatics approach.",2024,10.1016/j.bbrep.2024.101651,https://pubmed.ncbi.nlm.nih.gov/38371523/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,39583501,Primary Renal Synovial Sarcoma: A Rare Case Presentation.,2024,10.7759/cureus.72256,https://pubmed.ncbi.nlm.nih.gov/39583501/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,33287125,Cancer Testis Antigens and Immunotherapy: Expression of PRAME Is Associated with Prognosis in Soft Tissue Sarcoma.,2020,10.3390/cancers12123612,https://pubmed.ncbi.nlm.nih.gov/33287125/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,35860837,Multi-antigen-targeted T-cell therapy to treat patients with relapsed/refractory breast cancer.,2022,10.1177/17588359221107113,https://pubmed.ncbi.nlm.nih.gov/35860837/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,39391249,Molecular genetic characterization of myeloid neoplasms with idic(X)(q13) and i(X)(q10).,2024,10.3389/fonc.2024.1428984,https://pubmed.ncbi.nlm.nih.gov/39391249/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,33507803,T-Cell Therapy for Lymphoma Using Nonengineered Multiantigen-Targeted T Cells Is Safe and Produces Durable Clinical Effects.,2021,10.1200/jco.20.02224,https://pubmed.ncbi.nlm.nih.gov/33507803/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,38509571,Cross-reactive CD8+ T cell responses to tumor-associated antigens (TAAs) and homologous microbiota-derived antigens (MoAs).,2024,10.1186/s13046-024-03004-z,https://pubmed.ncbi.nlm.nih.gov/38509571/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,30186454,Antitumor effect of recombinant Mycobacterium smegmatis expressing MAGEA3 and SSX2 fusion proteins.,2018,10.3892/etm.2018.6425,https://pubmed.ncbi.nlm.nih.gov/30186454/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,40416104,Epithelial-Predominant Synovial Sarcoma With a Deceptive Neuroendocrine Phenotype.,2025,10.7759/cureus.82988,https://pubmed.ncbi.nlm.nih.gov/40416104/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,34496797,Distinct tumour antigen-specific T-cell immune response profiles at different hepatocellular carcinoma stages.,2021,10.1186/s12885-021-08720-9,https://pubmed.ncbi.nlm.nih.gov/34496797/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,30485425,Targeting the arginine metabolic brake enhances immunotherapy for leukaemia.,2019,10.1002/ijc.32028,https://pubmed.ncbi.nlm.nih.gov/30485425/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,29786040,Human Leukocyte Antigen-A Allele Distribution in Nasopharyngeal Carcinoma Patients Showing Anti-Melanoma-Associated Antigen A or Synovial Sarcoma X-2 T Cell Response in Blood.,2018,10.4103/0366-6999.232791,https://pubmed.ncbi.nlm.nih.gov/29786040/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,32943495,Patient-derived malignant pleural mesothelioma cell cultures: a tool to advance biomarker-driven treatments.,2020,10.1136/thoraxjnl-2020-215027,https://pubmed.ncbi.nlm.nih.gov/32943495/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2,ENSG00000241476,CTA,36809789,Defining a cohort of anemia-activated cis elements reveals a mechanism promoting erythroid precursor function.,2023,10.1182/bloodadvances.2022009163,https://pubmed.ncbi.nlm.nih.gov/36809789/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2B,ENSG00000268447,CTA,42883856,Distinct and Convergent Roles of the Synovial Sarcoma X Breakpoint Family of Cancer-Testis Antigens in Ovarian Cancer.,2026,10.3390/ijms27198608,https://pubmed.ncbi.nlm.nih.gov/42883856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2B,ENSG00000268447,CTA,40709507,Placental Gene Expression Associated With Early Childhood Growth Trajectories and Obesity Risk.,2025,10.1002/oby.70000,https://pubmed.ncbi.nlm.nih.gov/40709507/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2B,ENSG00000268447,CTA,39391249,Molecular genetic characterization of myeloid neoplasms with idic(X)(q13) and i(X)(q10).,2024,10.3389/fonc.2024.1428984,https://pubmed.ncbi.nlm.nih.gov/39391249/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2B,ENSG00000268447,CTA,31232935,Clinical application of RNA sequencing in sarcoma diagnosis: An institutional experience.,2019,10.1097/md.0000000000016031,https://pubmed.ncbi.nlm.nih.gov/31232935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,42883856,Distinct and Convergent Roles of the Synovial Sarcoma X Breakpoint Family of Cancer-Testis Antigens in Ovarian Cancer.,2026,10.3390/ijms27198608,https://pubmed.ncbi.nlm.nih.gov/42883856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,42053674,Integrative systems biology and drug repurposing reveal key regulatory hubs and a prognostic signature in gastric cancer.,2026,10.1007/s12672-026-04989-z,https://pubmed.ncbi.nlm.nih.gov/42053674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,37241221,Higher Expression Levels of SSX1 and SSX2 in Patients with Colon Cancer: Regulated In Vitro by the Inhibition of Methylation and Histone Deacetylation.,2023,10.3390/medicina59050988,https://pubmed.ncbi.nlm.nih.gov/37241221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,38050902,Expanding the molecular landscape of undifferentiated sarcomas of bone with a novel EWSR1-SSX3 gene fusion.,2024,10.1002/gcc.23215,https://pubmed.ncbi.nlm.nih.gov/38050902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,41139024,Expanding the Clinicopathologic Spectrum of EWSR1::SSX-Rearranged Sarcomas: Series of 11 Cases Including Osteosarcomas and a Novel EWSR1::SSX4 Fusion.,2026,10.1016/j.modpat.2025.100922,https://pubmed.ncbi.nlm.nih.gov/41139024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,34729377,Novel TCR-like CAR-T cells targeting an HLA∗0201-restricted SSX2 epitope display strong activity against acute myeloid leukemia.,2021,10.1016/j.omtm.2021.09.008,https://pubmed.ncbi.nlm.nih.gov/34729377/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,36017582,Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia.,2022,10.1111/andr.13269,https://pubmed.ncbi.nlm.nih.gov/36017582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,36140731,Identification of Differentially Expressed Genes and Prediction of Expression Regulation Networks in Dysfunctional Endothelium.,2022,10.3390/genes13091563,https://pubmed.ncbi.nlm.nih.gov/36140731/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,33816287,Identification and Validation of the Prognostic Stemness Biomarkers in Bladder Cancer Bone Metastasis.,2021,10.3389/fonc.2021.641184,https://pubmed.ncbi.nlm.nih.gov/33816287/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,24645645,SSX2-4 expression in early-stage non-small cell lung cancer.,2014,10.1111/tan.12340,https://pubmed.ncbi.nlm.nih.gov/24645645/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,30850364,Serum Proteomic Signatures of Male Breast Cancer.,2019,10.21873/cgp.20118,https://pubmed.ncbi.nlm.nih.gov/30850364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,29707408,A De Novo Xp11.23 Duplication in a Girl with a Severe Phenotype: Expanding the Clinical Spectrum.,2018,10.1055/s-0037-1612598,https://pubmed.ncbi.nlm.nih.gov/29707408/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,25587357,A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma.,2014,10.1186/s13073-014-0105-3,https://pubmed.ncbi.nlm.nih.gov/25587357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,12216073,The SSX gene family: characterization of 9 complete genes.,2002,10.1002/ijc.10634,https://pubmed.ncbi.nlm.nih.gov/12216073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,9378559,SSX: a multigene family with several members transcribed in normal testis and human cancer.,1997,10.1002/(sici)1097-0215(19970917)72:6<965::aid-ijc8>3.0.co;2-n,https://pubmed.ncbi.nlm.nih.gov/9378559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,12007189,"The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP.",2002,10.1002/gcc.10073,https://pubmed.ncbi.nlm.nih.gov/12007189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,10749136,Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines.,2000,,https://pubmed.ncbi.nlm.nih.gov/10749136/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,8697803,A novel Krüppel-associated box containing the SSX gene (SSX3) on the human X chromosome is not implicated in t(X;18)-positive synovial sarcomas.,1996,10.1159/000134334,https://pubmed.ncbi.nlm.nih.gov/8697803/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,9639388,Expression of SSX genes in human tumors.,1998,10.1002/(sici)1097-0215(19980703)77:1<19::aid-ijc4>3.0.co;2-2,https://pubmed.ncbi.nlm.nih.gov/9639388/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,14533943,SSX antigens as tumor vaccine targets in human sarcoma.,2003,,https://pubmed.ncbi.nlm.nih.gov/14533943/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,35462014,"Detection and molecular characteristics of canine coronavirus in Chengdu city, Southwest China from 2020 to 2021.",2022,10.1016/j.micpath.2022.105548,https://pubmed.ncbi.nlm.nih.gov/35462014/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX3,ENSG00000165584,CTA,20946665,A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer.,2010,10.1186/bcr2753,https://pubmed.ncbi.nlm.nih.gov/20946665/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,41139024,Expanding the Clinicopathologic Spectrum of EWSR1::SSX-Rearranged Sarcomas: Series of 11 Cases Including Osteosarcomas and a Novel EWSR1::SSX4 Fusion.,2026,10.1016/j.modpat.2025.100922,https://pubmed.ncbi.nlm.nih.gov/41139024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,40416104,Epithelial-Predominant Synovial Sarcoma With a Deceptive Neuroendocrine Phenotype.,2025,10.7759/cureus.82988,https://pubmed.ncbi.nlm.nih.gov/40416104/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,39333597,CD8 + T-cells restrict the development of peritoneal metastasis and support the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC).,2024,10.1038/s41598-024-72826-w,https://pubmed.ncbi.nlm.nih.gov/39333597/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,36452477,Epigenetic modulation enhances immunotherapy for pancreatic ductal adenocarcinoma.,2022,10.1002/cti2.1430,https://pubmed.ncbi.nlm.nih.gov/36452477/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,33963590,Expression of the C-terminal region of the SSX protein is a useful diagnostic biomarker for spermatocytic tumour.,2021,10.1111/his.14398,https://pubmed.ncbi.nlm.nih.gov/33963590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,37900632,Primary Gastric Synovial Sarcoma in a Young Male: a Rare Case Report and Review of Literature.,2023,10.1007/s13193-023-01738-4,https://pubmed.ncbi.nlm.nih.gov/37900632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,28438869,Correlation Between Expression of the Cancer/Testis Antigen KK-LC-1 and Helicobacter pylori Infection in Gastric Cancer.,2017,10.21873/invivo.11073,https://pubmed.ncbi.nlm.nih.gov/28438869/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,34157484,Identification of ARGLU1 as a potential therapeutic target for gastric cancer based on genome-wide functional screening data.,2021,10.1016/j.ebiom.2021.103436,https://pubmed.ncbi.nlm.nih.gov/34157484/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,24710929,Expression of cancer-testis antigen in multiple myeloma.,2014,10.1007/s11596-014-1255-7,https://pubmed.ncbi.nlm.nih.gov/24710929/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,37972927,Synovial Sarcoma of the Gastrointestinal Tract.,2024,10.1016/j.modpat.2023.100383,https://pubmed.ncbi.nlm.nih.gov/37972927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,30680066,Proteomic signatures corresponding to the SS18/SSX fusion gene in synovial sarcoma.,2018,10.18632/oncotarget.26493,https://pubmed.ncbi.nlm.nih.gov/30680066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,24645645,SSX2-4 expression in early-stage non-small cell lung cancer.,2014,10.1111/tan.12340,https://pubmed.ncbi.nlm.nih.gov/24645645/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,27294163,"Adjuvant Autologous Melanoma Vaccine for Macroscopic Stage III Disease: Survival, Biomarkers, and Improved Response to CTLA-4 Blockade.",2016,10.1155/2016/8121985,https://pubmed.ncbi.nlm.nih.gov/27294163/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,19746211,Detection of lung cancer using MAGE A1-6 and SSX4 RT-PCR expression profiles in the bronchial wash fluid.,2007,10.4143/crt.2007.39.2.69,https://pubmed.ncbi.nlm.nih.gov/19746211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,29707408,A De Novo Xp11.23 Duplication in a Girl with a Severe Phenotype: Expanding the Clinical Spectrum.,2018,10.1055/s-0037-1612598,https://pubmed.ncbi.nlm.nih.gov/29707408/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,31232935,Clinical application of RNA sequencing in sarcoma diagnosis: An institutional experience.,2019,10.1097/md.0000000000016031,https://pubmed.ncbi.nlm.nih.gov/31232935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,27331623,"The ""melanoma-enriched"" microRNA miR-4731-5p acts as a tumour suppressor.",2016,10.18632/oncotarget.10109,https://pubmed.ncbi.nlm.nih.gov/27331623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,17320278,Potential target antigens for immunotherapy in human pancreatic cancer.,2007,10.1016/j.canlet.2007.01.003,https://pubmed.ncbi.nlm.nih.gov/17320278/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,21347689,Identification and functional characterization of glioma-specific promoters and their application in suicide gene therapy.,2011,10.1007/s11060-010-0522-0,https://pubmed.ncbi.nlm.nih.gov/21347689/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,23625514,Effects of CT-Xp gene knock down in melanoma cell lines.,2013,10.18632/oncotarget.921,https://pubmed.ncbi.nlm.nih.gov/23625514/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,23619976,EBV-transformed lymphoblastoid cell lines as vaccines against cancer testis antigen-positive tumors.,2013,10.1007/s00262-013-1412-z,https://pubmed.ncbi.nlm.nih.gov/23619976/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,16428478,Expression of synovial sarcoma X (SSX) antigens in epithelial ovarian cancer and identification of SSX-4 epitopes recognized by CD4+ T cells.,2006,10.1158/1078-0432.ccr-05-1902,https://pubmed.ncbi.nlm.nih.gov/16428478/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,15814740,CD4+ T cell responses to SSX-4 in melanoma patients.,2005,10.4049/jimmunol.174.8.5092,https://pubmed.ncbi.nlm.nih.gov/15814740/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,14533943,SSX antigens as tumor vaccine targets in human sarcoma.,2003,,https://pubmed.ncbi.nlm.nih.gov/14533943/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,16224274,"SSX cancer testis antigens are expressed in most multiple myeloma patients: co-expression of SSX1, 2, 4, and 5 correlates with adverse prognosis and high frequencies of SSX-positive PCs.",2005,10.1097/01.cji.0000175685.36239.e5,https://pubmed.ncbi.nlm.nih.gov/16224274/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,14512184,Expression of cancer/testis (CT) antigens in lung cancer.,2003,10.1016/s0169-5002(03)00244-7,https://pubmed.ncbi.nlm.nih.gov/14512184/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,11531257,Expression of multiple cancer-testis antigen genes in gastrointestinal and breast carcinomas.,2001,10.1054/bjoc.2001.1974,https://pubmed.ncbi.nlm.nih.gov/11531257/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4,ENSG00000268009,CTA,15466353,Expression of cancer-testis antigen (CTA) genes in intrahepatic cholangiocarcinoma.,2004,10.1245/aso.2004.01.029,https://pubmed.ncbi.nlm.nih.gov/15466353/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX4B,ENSG00000269791,CTA,27331623,"The ""melanoma-enriched"" microRNA miR-4731-5p acts as a tumour suppressor.",2016,10.18632/oncotarget.10109,https://pubmed.ncbi.nlm.nih.gov/27331623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX5,ENSG00000165583,CTA,21880588,Expression and immunotherapeutic targeting of the SSX family of cancer-testis antigens in prostate cancer.,2011,10.1158/0008-5472.can-11-2127,https://pubmed.ncbi.nlm.nih.gov/21880588/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX5,ENSG00000165583,CTA,16546222,Expression of cancer-testis antigen (CTA) in tumor tissues and peripheral blood of Chinese patients with hepatocellular carcinoma.,2006,10.1016/j.lfs.2006.02.024,https://pubmed.ncbi.nlm.nih.gov/16546222/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX5,ENSG00000165583,CTA,17023585,Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation.,2007,10.1182/blood-2006-04-014480,https://pubmed.ncbi.nlm.nih.gov/17023585/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX5,ENSG00000165583,CTA,15723723,Expression of cancer/testis (CT) antigens in Chinese hepatocellular carcinoma and its correlation with clinical parameters.,2005,10.1016/j.canlet.2004.07.028,https://pubmed.ncbi.nlm.nih.gov/15723723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX5,ENSG00000165583,CTA,16224274,"SSX cancer testis antigens are expressed in most multiple myeloma patients: co-expression of SSX1, 2, 4, and 5 correlates with adverse prognosis and high frequencies of SSX-positive PCs.",2005,10.1097/01.cji.0000175685.36239.e5,https://pubmed.ncbi.nlm.nih.gov/16224274/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX5,ENSG00000165583,CTA,9378559,SSX: a multigene family with several members transcribed in normal testis and human cancer.,1997,10.1002/(sici)1097-0215(19970917)72:6<965::aid-ijc8>3.0.co;2-n,https://pubmed.ncbi.nlm.nih.gov/9378559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX5,ENSG00000165583,CTA,12007189,"The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP.",2002,10.1002/gcc.10073,https://pubmed.ncbi.nlm.nih.gov/12007189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX5,ENSG00000165583,CTA,10749136,Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines.,2000,,https://pubmed.ncbi.nlm.nih.gov/10749136/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX5,ENSG00000165583,CTA,9639388,Expression of SSX genes in human tumors.,1998,10.1002/(sici)1097-0215(19980703)77:1<19::aid-ijc4>3.0.co;2-2,https://pubmed.ncbi.nlm.nih.gov/9639388/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX5,ENSG00000165583,CTA,9688183,"Detection of the SYT-SSX fusion transcripts in formaldehyde-fixed, paraffin-embedded tissue: a reverse transcription polymerase chain reaction amplification assay useful in the diagnosis of synovial sarcoma.",1998,,https://pubmed.ncbi.nlm.nih.gov/9688183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,42183021,The pachytene-specific lncRNA &lt;i&gt;1700008K24Rik&lt;/i&gt; is essential for mouse spermatogenesis and functions as a conserved piRNA precursor.,2026,10.1016/j.ncrna.2026.04.001,https://pubmed.ncbi.nlm.nih.gov/42183021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,41716322,Effect of arginine on proliferation of porcine ovarian granulosa cells and steroid hormone synthesis.,2026,10.3389/fvets.2026.1766335,https://pubmed.ncbi.nlm.nih.gov/41716322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,38829257,"Differential regulation of STARD1, STARD4 and STARD6 in the human ovary.",2024,10.1530/joe-23-0385,https://pubmed.ncbi.nlm.nih.gov/38829257/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,33907405,"Association Analysis of Polymorphisms in BIN1, MC1R, STARD6 and PVRL2 with Mild Cognitive Impairment in Elderly Carrying APOE ε4 Allele.",2021,10.2147/ndt.s296144,https://pubmed.ncbi.nlm.nih.gov/33907405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,30666118,Association analysis of polymorphisms in STARD6 and near ECHDC3 in Alzheimer's disease patients carrying the APOE ε4 Allele.,2019,10.2147/ndt.s186705,https://pubmed.ncbi.nlm.nih.gov/30666118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,35135506,Evaluation of mild cognitive impairment genetic susceptibility risks in a Chinese population.,2022,10.1186/s12888-022-03756-y,https://pubmed.ncbi.nlm.nih.gov/35135506/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,24595982,STARD6 is expressed in steroidogenic cells of the ovary and can enhance de novo steroidogenesis.,2014,10.1177/1535370213517616,https://pubmed.ncbi.nlm.nih.gov/24595982/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,24360190,A comparison of the steroidogenic acute regulatory protein-related lipid transfer (START) domain-containing 6 on the brain and testes between young and aged rats.,2014,10.1016/j.acthis.2013.11.008,https://pubmed.ncbi.nlm.nih.gov/24360190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,27340016,"STARD6 on steroids: solution structure, multiple timescale backbone dynamics and ligand binding mechanism.",2016,10.1038/srep28486,https://pubmed.ncbi.nlm.nih.gov/27340016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,26016904,Gene expression during testis development in Duroc boars.,2015,10.1017/s1751731115000907,https://pubmed.ncbi.nlm.nih.gov/26016904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,17885612,Immunohistochemical detection of StarD6 in the rat nervous system.,2007,10.1097/wnr.0b013e3282f0402f,https://pubmed.ncbi.nlm.nih.gov/17885612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,24440759,The StarD4 subfamily of steroidogenic acute regulatory-related lipid transfer (START) domain proteins: new players in cholesterol metabolism.,2014,10.1016/j.biocel.2014.01.002,https://pubmed.ncbi.nlm.nih.gov/24440759/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,22024186,Immunolocalization of steroidogenic acute regulatory protein-related lipid transfer (START) domain-containing proteins in the developing cerebellum of normal and hypothyroid rats.,2012,10.1016/j.jchemneu.2011.10.003,https://pubmed.ncbi.nlm.nih.gov/22024186/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,22869527,Multiple cancer testis antigens function to support tumor cell mitotic fidelity.,2012,10.1128/mcb.00686-12,https://pubmed.ncbi.nlm.nih.gov/22869527/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,27539716,Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice.,2016,10.1007/s10162-016-0578-4,https://pubmed.ncbi.nlm.nih.gov/27539716/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,15564601,Expression of the putative sterol binding protein Stard6 gene is male germ cell specific.,2005,10.1095/biolreprod.104.032672,https://pubmed.ncbi.nlm.nih.gov/15564601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,17462719,The changed immunolocalization of START-domain-containing 6 (StarD6) during the development of testes in rat perinatal hypothyroidism.,2007,10.1016/j.acthis.2007.03.001,https://pubmed.ncbi.nlm.nih.gov/17462719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,19434006,The changed immunoreactivity of StarD6 after pilocarpine-induced epilepsy.,2009,10.1097/wnr.0b013e32832ca264,https://pubmed.ncbi.nlm.nih.gov/19434006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,25542846,The binding site specificity of STARD4 subfamily: Breaking the cholesterol paradigm.,2015,10.1016/j.mce.2014.12.016,https://pubmed.ncbi.nlm.nih.gov/25542846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,20609383,Does the StarD6 mark the same as the StAR in the nervous system?,2010,10.1016/j.jchemneu.2010.06.006,https://pubmed.ncbi.nlm.nih.gov/20609383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STARD6,ENSG00000174448,CTA,29688061,Molecular activities and ligand-binding specificities of StAR-related lipid transfer domains: exploring integrated in silico methods and ensemble-docking approaches.,2018,10.1080/1062936x.2018.1462847,https://pubmed.ncbi.nlm.nih.gov/29688061/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,41855266,SUN5 forms a regular protein lattice reinforcing the sperm head-tail junction.,2026,10.1073/pnas.2520626123,https://pubmed.ncbi.nlm.nih.gov/41855266/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,42829918,WFS1 Deficiency Impairs PIAS4-Associated SUMOylation and Increases Ubiquitin-Mediated Spermatogenesis-Related Protein Degradation Leading to Testicular Male Infertility.,2026,10.1002/advs.78060,https://pubmed.ncbi.nlm.nih.gov/42829918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,41311215,"SUN5 interacts with TRIM28, enhancing IκBα ubiquitination to promote glycolysis in colorectal cancer cells.",2025,10.3724/abbs.2025201,https://pubmed.ncbi.nlm.nih.gov/41311215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,40740627,Novel SUN5 Mutation Associated with Acephalic Spermatozoa Syndrome: A Cross-sectional Study.,2025,10.4103/jhrs.jhrs_37_25,https://pubmed.ncbi.nlm.nih.gov/40740627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,42522282,Novel mutations in ZMYND15 expand the phenotypic spectrum to acephalic spermatozoa: abnormal sperm head-tail connection mediated by SUN5.,2026,10.4103/aja2025109,https://pubmed.ncbi.nlm.nih.gov/42522282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,39108207,"SUN5, a testis-specific nuclear membrane protein, participates in recruitment and export of nuclear mRNA in spermatogenesis.",2024,10.3724/abbs.2024134,https://pubmed.ncbi.nlm.nih.gov/39108207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,38870534,SUN5 interacts with nuclear membrane LaminB1 and cytoskeletal GTPase Septin12 mediating the sperm head-and-tail junction.,2024,10.1093/molehr/gaae022,https://pubmed.ncbi.nlm.nih.gov/38870534/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,39671309,CCDC113 stabilizes sperm axoneme and head-tail coupling apparatus to ensure male fertility.,2024,10.7554/elife.98016,https://pubmed.ncbi.nlm.nih.gov/39671309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,41035184,The mid-SUN-POD1 complex ensures the structural integrity of ER bodies required for herbivore defense in Arabidopsis.,2026,10.1111/nph.70613,https://pubmed.ncbi.nlm.nih.gov/41035184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,42541972,Spermidine and melatonin ameliorate heat stress-induced decline in sheep semen quality.,2026,10.1016/j.theriogenology.2026.118112,https://pubmed.ncbi.nlm.nih.gov/42541972/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,36358787,Nuclear Membrane Protein SUN5 Is Highly Expressed and Promotes Proliferation and Migration in Colorectal Cancer by Regulating the ERK Pathway.,2022,10.3390/cancers14215368,https://pubmed.ncbi.nlm.nih.gov/36358787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,38559585,The mutation of NSUN5 R295C promotes preeclampsia by impairing decidualization through downregulating IL-11Rα.,2024,10.1016/j.isci.2024.108899,https://pubmed.ncbi.nlm.nih.gov/38559585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,39726222,A homozygous loss-of-function mutation in CEP250 is associated with acephalic spermatozoa syndrome in humans.,2025,10.1111/andr.13827,https://pubmed.ncbi.nlm.nih.gov/39726222/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,34389728,The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus.,2021,10.1038/s41467-021-25227-w,https://pubmed.ncbi.nlm.nih.gov/34389728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,34268309,SUN5 Interacting With Nesprin3 Plays an Essential Role in Sperm Head-to-Tail Linkage: Research on Sun5 Gene Knockout Mice.,2021,10.3389/fcell.2021.684826,https://pubmed.ncbi.nlm.nih.gov/34268309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,37997706,ARRDC5 deficiency impairs spermatogenesis by affecting SUN5 and NDC1.,2023,10.1242/dev.201959,https://pubmed.ncbi.nlm.nih.gov/37997706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,31144711,SPAG4L/SPAG4Lβ interacts with Nesprin2 to participate in the meiosis of spermatogenesis.,2019,10.1093/abbs/gmz051,https://pubmed.ncbi.nlm.nih.gov/31144711/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,39506588,Identification of Potential Biomarkers Associated with Spermatogenesis in Azoospermia.,2024,10.7754/clin.lab.2024.240541,https://pubmed.ncbi.nlm.nih.gov/39506588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,33671757,Identification and Characterization of the Most Common Genetic Variant Responsible for Acephalic Spermatozoa Syndrome in Men Originating from North Africa.,2021,10.3390/ijms22042187,https://pubmed.ncbi.nlm.nih.gov/33671757/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,25775128,Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope.,2015,10.1371/journal.pone.0118698,https://pubmed.ncbi.nlm.nih.gov/25775128/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN5,ENSG00000167098,CTA,27640305,Biallelic SUN5 Mutations Cause Autosomal-Recessive Acephalic Spermatozoa Syndrome.,2016,10.1016/j.ajhg.2016.08.004,https://pubmed.ncbi.nlm.nih.gov/27640305/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
SUN5,ENSG00000167098,CTA,21711156,"SPAG4L, a novel nuclear envelope protein involved in the meiotic stage of spermatogenesis.",2011,10.1089/dna.2010.1161,https://pubmed.ncbi.nlm.nih.gov/21711156/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
SUN5,ENSG00000167098,CTA,12621555,"[Cloning of cDNA of TSARG4, a human spermatogenesis related gene].",2003,,https://pubmed.ncbi.nlm.nih.gov/12621555/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
SYCP1,ENSG00000198765,CTA,42418586,"Moonlighting role of meiotic SYCP1 in breast cancer: A chromatin-bound regulator of DNA repair, transcription, and drug resistance.",2026,10.1126/sciadv.aea2067,https://pubmed.ncbi.nlm.nih.gov/42418586/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,42736190,Integrated transcriptomic and metabolomic analysis of the hypothalamic-pituitary-testicular axis in rooster lines with contrasting hatchability.,2026,10.1016/j.psj.2026.107728,https://pubmed.ncbi.nlm.nih.gov/42736190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,41411337,Contrasting effects of DNA demethylation on cancer-germline gene expression in breast cancer and leukemia cells.,2025,10.1371/journal.pone.0339460,https://pubmed.ncbi.nlm.nih.gov/41411337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,42673516,LncRNA THOR regulates spermatogenesis by interacting with and stabilizing Sycp3 protein in zebrafish†.,2026,10.1093/biolre/ioag185,https://pubmed.ncbi.nlm.nih.gov/42673516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,42854377,Meiotic recombination proteins in cancer.,2026,10.1016/j.dnarep.2026.103963,https://pubmed.ncbi.nlm.nih.gov/42854377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,42913001,The &lt;i&gt;Nematostella&lt;/i&gt; synaptonemal complex mediates divergent and sex-specific meiotic programs.,2026,10.1126/sciadv.aei0758,https://pubmed.ncbi.nlm.nih.gov/42913001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,42792869,Ubc9 Mediates SUMO2/3 Modification to Regulate Meiosis in Male Mice.,2026,10.3390/biomedicines14092129,https://pubmed.ncbi.nlm.nih.gov/42792869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,42381596,eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes.,2026,10.1002/advs.76264,https://pubmed.ncbi.nlm.nih.gov/42381596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,40911633,Distinct cellular and reproductive consequences of meiotic chromosome synapsis defects in syce2 and sycp1 mutant zebrafish.,2025,10.1371/journal.pgen.1011656,https://pubmed.ncbi.nlm.nih.gov/40911633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,42297203,An asynchronous production line of meiotic prophase I in the mouse fetal ovary.,2026,10.1016/j.yexcr.2026.115099,https://pubmed.ncbi.nlm.nih.gov/42297203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,42059593,"The synaptonemal complex: structure, function, and clinical implications†.",2026,10.1093/biolre/ioag092,https://pubmed.ncbi.nlm.nih.gov/42059593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,39208330,"Differential expression and regulation of ADAD1, DMRTC2, PRSS54, SYCE1, SYCP1, TEX101, TEX48, and TMPRSS12 gene profiles in colon cancer tissues and their in vitro response to epigenetic drugs.",2024,10.1371/journal.pone.0307724,https://pubmed.ncbi.nlm.nih.gov/39208330/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,40713602,The synergic impact of decellularized testis scaffold and extracellular vesicles derived from human semen on spermatogonial stem cell survival and differentiation.,2025,10.1186/s12938-025-01424-2,https://pubmed.ncbi.nlm.nih.gov/40713602/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,42258539,Stable inheritance of the Streptomyces linear plasmid SCP1 by dual ParABS partition systems.,2026,10.1093/nar/gkag593,https://pubmed.ncbi.nlm.nih.gov/42258539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,39921484,hnRNPC Functions with HuR to Regulate Alternative Splicing in an m6A-Dependent Manner and is Essential for Meiosis.,2025,10.1002/advs.202412196,https://pubmed.ncbi.nlm.nih.gov/39921484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,41249143,Somatic Kitl promotes mTOR to facilitate prophase I of meiosis in female embryonic gonads.,2025,10.1038/s41419-025-08158-y,https://pubmed.ncbi.nlm.nih.gov/41249143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,41339899,"Genetic and epigenetic insights into non-obstructive azoospermia: mechanisms, biomarkers, and clinical perspectives.",2025,10.1186/s12958-025-01497-7,https://pubmed.ncbi.nlm.nih.gov/41339899/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,42287814,Saikosaponin A restores the IDO1-driven gut-testis kynurenine axis to alleviate oligozoospermia.,2026,10.1016/j.phymed.2026.158414,https://pubmed.ncbi.nlm.nih.gov/42287814/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,41093233,Multi-omics analysis reveals fluorinated liquid crystal monomers BDPrB/EDPrB exposure disrupts the steroid biosynthesis function via inhibition of CYP17A1.,2025,10.1016/j.envpol.2025.127253,https://pubmed.ncbi.nlm.nih.gov/41093233/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,39966702,Comprehensive analysis of long non-coding RNA and mRNA expression patterns during seminiferous tubules maturation in Guanzhong dairy goats.,2025,10.1186/s12864-025-11320-7,https://pubmed.ncbi.nlm.nih.gov/39966702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,39756766,Identification of two novel α-amylase inhibitory activity peptide from Russian sea cucumber body wallprotein hydrolysate.,2025,10.1016/j.ijbiomac.2025.139499,https://pubmed.ncbi.nlm.nih.gov/39756766/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,41121288,DNA methylation profiles and cancer in children conceived after assisted reproductive technology.,2025,10.1186/s13148-025-01982-1,https://pubmed.ncbi.nlm.nih.gov/41121288/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,39106567,Multiple omics integration analysis reveals the regulatory effect of chitosan oligosaccharide on testicular development.,2024,10.1016/j.ecoenv.2024.116802,https://pubmed.ncbi.nlm.nih.gov/39106567/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,32497486,Efficacy of co-immunization with the DNA and peptide vaccines containing SYCP1 and ACRBP epitopes in a murine triple-negative breast cancer model.,2021,10.1080/21645515.2020.1763693,https://pubmed.ncbi.nlm.nih.gov/32497486/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,38994027,Adeno-associated-virus-mediated delivery of CRISPR-CasRx induces efficient RNA knockdown in the mouse testis.,2024,10.7150/thno.95633,https://pubmed.ncbi.nlm.nih.gov/38994027/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,36228355,Decabromodiphenyl ethane induces male reproductive toxicity by glycolipid metabolism imbalance and meiotic failure.,2022,10.1016/j.ecoenv.2022.114165,https://pubmed.ncbi.nlm.nih.gov/36228355/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,34931516,Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells.,2022,10.1021/acs.jmedchem.1c01655,https://pubmed.ncbi.nlm.nih.gov/34931516/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,38135418,Decabromodiphenyl ether induces the chromosome association disorders of spermatocytes and deformation failures of spermatids in mice.,2024,10.1016/j.jes.2023.03.043,https://pubmed.ncbi.nlm.nih.gov/38135418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,31499268,"Production, purification, and in vivo evaluation of a novel multiepitope peptide vaccine consisted of immunodominant epitopes of SYCP1 and ACRBP antigens as a prophylactic melanoma vaccine.",2019,10.1016/j.intimp.2019.105872,https://pubmed.ncbi.nlm.nih.gov/31499268/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,32042403,Cancer/testis antigens expression during cultivation of melanoma and soft tissue sarcoma cells.,2020,10.1186/s13569-020-0125-2,https://pubmed.ncbi.nlm.nih.gov/32042403/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,38609948,Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells.,2024,10.1186/s12915-024-01879-0,https://pubmed.ncbi.nlm.nih.gov/38609948/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,35082515,Role of Hub Genes in the Occurrence and Development of Testicular Cancer Based on Bioinformatics.,2022,10.2147/ijgm.s342611,https://pubmed.ncbi.nlm.nih.gov/35082515/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,35447802,Assessing Near-Infrared Spectroscopy (NIRS) for Evaluation of Aedes aegypti Population Age Structure.,2022,10.3390/insects13040360,https://pubmed.ncbi.nlm.nih.gov/35447802/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,30217818,Phosphatase activity of small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST).,2018,10.1074/jbc.ra118.004722,https://pubmed.ncbi.nlm.nih.gov/30217818/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,25692886,Solomonseal polysaccharide and sulfated Codonopsis pilosula polysaccharide synergistically resist Newcastle disease virus.,2015,10.1371/journal.pone.0117916,https://pubmed.ncbi.nlm.nih.gov/25692886/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP1,ENSG00000198765,CTA,9371398,Assignment of synaptonemal complex protein 1 (SCP1) to human chromosome 1p13 by fluorescence in situ hybridization and its expression in the testis.,1997,10.1159/000134637,https://pubmed.ncbi.nlm.nih.gov/9371398/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D21,ENSG00000167139,CTA,39907412,Microbial signatures in head and neck squamous cell carcinoma: an in silico study.,2025,10.1590/1678-7757-2024-0392,https://pubmed.ncbi.nlm.nih.gov/39907412/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D21,ENSG00000167139,CTA,35403672,TBC1D21 is an essential factor for sperm mitochondrial sheath assembly and male fertility‡.,2022,10.1093/biolre/ioac069,https://pubmed.ncbi.nlm.nih.gov/35403672/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D21,ENSG00000167139,CTA,32976492,Deficiency of the Tbc1d21 gene causes male infertility with morphological abnormalities of the sperm mitochondria and flagellum in mice.,2020,10.1371/journal.pgen.1009020,https://pubmed.ncbi.nlm.nih.gov/32976492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D21,ENSG00000167139,CTA,33536340,ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility.,2021,10.1073/pnas.2018355118,https://pubmed.ncbi.nlm.nih.gov/33536340/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D21,ENSG00000167139,CTA,30360518,TBC1D21 Potentially Interacts with and Regulates Rap1 during Murine Spermatogenesis.,2018,10.3390/ijms19113292,https://pubmed.ncbi.nlm.nih.gov/30360518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D21,ENSG00000167139,CTA,36845001,Evaluation of the efficacy of creatine chemical exchange saturation transfer imaging in assessing testicular maturity.,2023,10.1002/rmb2.12507,https://pubmed.ncbi.nlm.nih.gov/36845001/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D21,ENSG00000167139,CTA,37956402,Dopamine receptor D2 regulates genes involved in germ cell movement and sperm motility in rat testes†.,2024,10.1093/biolre/ioad153,https://pubmed.ncbi.nlm.nih.gov/37956402/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D21,ENSG00000167139,CTA,39961484,Comparative proteomics and phosphoproteomics analysis reveals differential sperm motility in Mediterranean buffalo semen.,2025,10.1016/j.jprot.2025.105401,https://pubmed.ncbi.nlm.nih.gov/39961484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D21,ENSG00000167139,CTA,28067790,RAB10 Interacts with the Male Germ Cell-Specific GTPase-Activating Protein during Mammalian Spermiogenesis.,2017,10.3390/ijms18010097,https://pubmed.ncbi.nlm.nih.gov/28067790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D21,ENSG00000167139,CTA,21128978,Identification and characterization of a novel Rab GTPase-activating protein in spermatids.,2011,10.1111/j.1365-2605.2010.01126.x,https://pubmed.ncbi.nlm.nih.gov/21128978/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D21,ENSG00000167139,CTA,24938310,Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population.,2014,10.1038/srep05340,https://pubmed.ncbi.nlm.nih.gov/24938310/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D21,ENSG00000167139,CTA,31192002,Multiple Gene Polymorphisms Associated with Exfoliation Syndrome in the Uygur Population.,2019,10.1155/2019/9687823,https://pubmed.ncbi.nlm.nih.gov/31192002/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D28,ENSG00000189375,CTA,41701878,Longevity vs. Healthy Longevity: Different Outcomes Underlain by Different Mechanisms.,2026,10.14336/ad.2025.0828,https://pubmed.ncbi.nlm.nih.gov/41701878/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,40681857,Expression of marker genes to assess the spermatogenic capacity in patients with idiopathic non-obstructive azoospermia.,2025,10.1007/s10815-025-03584-5,https://pubmed.ncbi.nlm.nih.gov/40681857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,37697257,"Increased TCP11 gene expression can inhibit the proliferation, migration and promote apoptosis of cervical cancer cells.",2023,10.1186/s12885-023-11129-1,https://pubmed.ncbi.nlm.nih.gov/37697257/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,31837139,Mouse t-complex protein 11 is important for progressive motility in sperm†.,2020,10.1093/biolre/ioz226,https://pubmed.ncbi.nlm.nih.gov/31837139/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,40600939,Endoplasmic reticulum stress genes and apoptosis-related genes effect cryotolerance: Two comparisons of balb/c and cd-1 mice.,2025,10.54680/fr25410110512,https://pubmed.ncbi.nlm.nih.gov/40600939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,35709667,Mixed model-based eQTL analysis reveals lncRNAs associated with regulation of genes involved in sex determination and spermatogenesis: The key to understanding human gender imbalance.,2022,10.1016/j.compbiolchem.2022.107713,https://pubmed.ncbi.nlm.nih.gov/35709667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,36308435,"Trans-ancestry, Bayesian meta-analysis discovers 20 novel risk loci for inflammatory bowel disease in an African American, East Asian and European cohort.",2023,10.1093/hmg/ddac269,https://pubmed.ncbi.nlm.nih.gov/36308435/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,35266640,Multi-stage screening cell-free seminal mRNAs to diagnose completion of meiosis and predict testicular sperm retrieval in men with non-obstructive azoospermia.,2022,10.1111/andr.13173,https://pubmed.ncbi.nlm.nih.gov/35266640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,29577858,Expression and Prognostic Relevance of GAGE1 and XAGE1 Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma.,2017,10.2174/1566524018666180322162145,https://pubmed.ncbi.nlm.nih.gov/29577858/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,21597245,"Human t-complex protein 11 (TCP11), a testis-specific gene product, is a potential determinant of the sperm morphology.",2011,10.1620/tjem.224.111,https://pubmed.ncbi.nlm.nih.gov/21597245/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,25999357,Spermatozoa protein alterations in infertile men with bilateral varicocele.,2016,10.4103/1008-682x.153848,https://pubmed.ncbi.nlm.nih.gov/25999357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,28088687,Whole-Genome DNA Methylation Profiling Identifies Epigenetic Signatures of Uterine Carcinosarcoma.,2017,10.1016/j.neo.2016.12.009,https://pubmed.ncbi.nlm.nih.gov/28088687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,31803223,Genome-Wide Differential Expression Profiling of Ovarian circRNAs Associated With Litter Size in Pigs.,2019,10.3389/fgene.2019.01010,https://pubmed.ncbi.nlm.nih.gov/31803223/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,27105888,"A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation.",2016,10.1096/fj.201500136r,https://pubmed.ncbi.nlm.nih.gov/27105888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,25973848,Differential Genes Expression between Fertile and Infertile Spermatozoa Revealed by Transcriptome Analysis.,2015,10.1371/journal.pone.0127007,https://pubmed.ncbi.nlm.nih.gov/25973848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,21241251,The Arabidopsis class I TCP transcription factor AtTCP11 is a developmental regulator with distinct DNA-binding properties due to the presence of a threonine residue at position 15 of the TCP domain.,2011,10.1042/bj20101019,https://pubmed.ncbi.nlm.nih.gov/21241251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,12905703,"[Cloning, expression, and alternative splicing of the novel isoform of hTCP11 gene].",2003,,https://pubmed.ncbi.nlm.nih.gov/12905703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,21183706,TCP transcription factors link the regulation of genes encoding mitochondrial proteins with the circadian clock in Arabidopsis thaliana.,2010,10.1105/tpc.110.074518,https://pubmed.ncbi.nlm.nih.gov/21183706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,11756566,Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide.,2002,10.1093/molehr/8.1.24,https://pubmed.ncbi.nlm.nih.gov/11756566/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,28379507,Impact of male fertility status on the transcriptome of the bovine epididymis.,2017,10.1093/molehr/gax019,https://pubmed.ncbi.nlm.nih.gov/28379507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11,ENSG00000124678,CTA,21995314,Assessment of heterogeneity between European Populations: a Baltic and Danish replication case-control study of SNPs from a recent European ulcerative colitis genome wide association study.,2011,10.1186/1471-2350-12-139,https://pubmed.ncbi.nlm.nih.gov/21995314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT5,ENSG00000153060,CTA,41764189,Doublet microtubule-associated tektins and enzymes differentially regulate sperm flagellar integrity and motility.,2026,10.1038/s41467-026-69714-4,https://pubmed.ncbi.nlm.nih.gov/41764189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT5,ENSG00000153060,CTA,42785075,Identification and evaluation of candidate sperm proteins associated with cryopreservation-induced changes in semen quality in Thai native roosters.,2026,10.1016/j.psj.2026.107802,https://pubmed.ncbi.nlm.nih.gov/42785075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT5,ENSG00000153060,CTA,37118964,Differential Proteomic Analysis of Human Sperm: A Systematic Review to Identify Candidate Targets to Monitor Sperm Quality.,2024,10.5534/wjmh.220262,https://pubmed.ncbi.nlm.nih.gov/37118964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT5,ENSG00000153060,CTA,36041235,Analysis of copy number variation in men with non-obstructive azoospermia.,2022,10.1111/andr.13267,https://pubmed.ncbi.nlm.nih.gov/36041235/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT5,ENSG00000153060,CTA,38061432,Transcriptome and proteome analyses reveal the mechanisms involved in polystyrene nanoplastics disrupt spermatogenesis in mice.,2024,10.1016/j.envpol.2023.123086,https://pubmed.ncbi.nlm.nih.gov/38061432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT5,ENSG00000153060,CTA,31208979,Comprehensive Analysis of Mouse Cancer/Testis Antigen Functions in Cancer Cells and Roles of TEKT5 in Cancer Cells and Testicular Germ Cells.,2019,10.1128/mcb.00154-19,https://pubmed.ncbi.nlm.nih.gov/31208979/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT5,ENSG00000153060,CTA,37865089,De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking.,2023,10.1016/j.cell.2023.09.017,https://pubmed.ncbi.nlm.nih.gov/37865089/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT5,ENSG00000153060,CTA,23151147,Serological identification of Tektin5 as a cancer/testis antigen and its immunogenicity.,2012,10.1186/1471-2407-12-520,https://pubmed.ncbi.nlm.nih.gov/23151147/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT5,ENSG00000153060,CTA,35565522,Identification of Candidate Genes for Pigmentation in Camels Using Genotyping-by-Sequencing.,2022,10.3390/ani12091095,https://pubmed.ncbi.nlm.nih.gov/35565522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT5,ENSG00000153060,CTA,20378928,"Characterization of a novel tektin member, TEKT5, in mouse sperm.",2011,10.2164/jandrol.109.009456,https://pubmed.ncbi.nlm.nih.gov/20378928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT5,ENSG00000153060,CTA,35959094,Sex-dimorphic gene effects on survival outcomes in people with coronary artery disease.,2022,10.1016/j.ahjo.2022.100152,https://pubmed.ncbi.nlm.nih.gov/35959094/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT5,ENSG00000153060,CTA,26635082,Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.,2015,10.1038/ncomms9658,https://pubmed.ncbi.nlm.nih.gov/26635082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB2,ENSG00000167014,CTA,42443317,Novel variants in LINC and TTM complexes of meiotic chromosome dynamics are associated with meiotic arrest and non-obstructive azoospermia.,2026,10.1038/s10038-026-01492-9,https://pubmed.ncbi.nlm.nih.gov/42443317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB2,ENSG00000167014,CTA,42400802,Identifying genetics biomarkers in correlation with pathological and PSMA PET/CT characteristics in prostate cancer.,2026,10.1186/s13550-026-01471-3,https://pubmed.ncbi.nlm.nih.gov/42400802/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB2,ENSG00000167014,CTA,33211200,"Disruption of human meiotic telomere complex genes TERB1, TERB2 and MAJIN in men with non-obstructive azoospermia.",2021,10.1007/s00439-020-02236-1,https://pubmed.ncbi.nlm.nih.gov/33211200/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB2,ENSG00000167014,CTA,32408858,The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back to the common ancestor of metazoans.,2020,10.1186/s12862-020-01612-9,https://pubmed.ncbi.nlm.nih.gov/32408858/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB2,ENSG00000167014,CTA,30718482,The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.,2019,10.1038/s41467-019-08437-1,https://pubmed.ncbi.nlm.nih.gov/30718482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB2,ENSG00000167014,CTA,35081355,The TERB1 MYB domain suppresses telomere erosion in meiotic prophase I.,2022,10.1016/j.celrep.2021.110289,https://pubmed.ncbi.nlm.nih.gov/35081355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB2,ENSG00000167014,CTA,30559341,Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1.,2018,10.1038/s41467-018-07794-7,https://pubmed.ncbi.nlm.nih.gov/30559341/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB2,ENSG00000167014,CTA,33015044,Tethering of Telomeres to the Nuclear Envelope Is Mediated by SUN1-MAJIN and Possibly Promoted by SPDYA-CDK2 During Meiosis.,2020,10.3389/fcell.2020.00845,https://pubmed.ncbi.nlm.nih.gov/33015044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX13A,ENSG00000268629,CTA,38378815,Genetic analysis of the X chromosome in people with Lewy body dementia nominates new risk loci.,2024,10.1038/s41531-024-00649-7,https://pubmed.ncbi.nlm.nih.gov/38378815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX13A,ENSG00000268629,CTA,37594251,Scrutinizing the human TEX genes in the context of human male infertility.,2024,10.1111/andr.13511,https://pubmed.ncbi.nlm.nih.gov/37594251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX13A,ENSG00000268629,CTA,34733855,Tex13a Optimizes Sperm Motility via Its Potential Roles in mRNA Turnover.,2021,10.3389/fcell.2021.761627,https://pubmed.ncbi.nlm.nih.gov/34733855/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX13A,ENSG00000268629,CTA,33811575,Analysis of mouse male germ cell-specific or -predominant Tex13 family genes encoding proteins with transcriptional repressor activity.,2021,10.1007/s11033-021-06265-5,https://pubmed.ncbi.nlm.nih.gov/33811575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX13A,ENSG00000268629,CTA,36017582,Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia.,2022,10.1111/andr.13269,https://pubmed.ncbi.nlm.nih.gov/36017582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX13A,ENSG00000268629,CTA,14531651,Molecular and cytogenetic characterization of two azoospermic patients with X-autosome translocation.,2003,10.1023/a:1025437329427,https://pubmed.ncbi.nlm.nih.gov/14531651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX13A,ENSG00000268629,CTA,21256132,Characterization of a family of RanBP2-type zinc fingers that can recognize single-stranded RNA.,2011,10.1016/j.jmb.2010.12.041,https://pubmed.ncbi.nlm.nih.gov/21256132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,41603674,"Pathogenic TEX14 Variants Disrupt Intercellular Bridge Formation, Causing Meiotic Arrest and Non-Obstructive Azoospermia in Humans and Mice.",2026,10.1111/andr.70185,https://pubmed.ncbi.nlm.nih.gov/41603674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,39929837,Intercellular bridges are essential for transposon repression and meiosis in the male germline.,2025,10.1038/s41467-025-56742-9,https://pubmed.ncbi.nlm.nih.gov/39929837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,39188605,"Correlation between TEX14 and ADAM17 expressions in colorectal cancer tissues of elderly patients and neoplasm staging, invasion, and metastasis.",2024,10.12998/wjcc.v12.i24.5492,https://pubmed.ncbi.nlm.nih.gov/39188605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,41366310,Plasma proteomic signatures in HIV-infected individuals post-SARS-CoV-2 infection.,2025,10.1186/s12879-025-12307-1,https://pubmed.ncbi.nlm.nih.gov/41366310/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,40528727,YKT6 Is Essential for Male Fertility by Promoting Meiosis Progression During Spermatogenesis of Mice.,2026,10.1111/cpr.70079,https://pubmed.ncbi.nlm.nih.gov/40528727/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,40492599,A Novel Compound Heterozygous Mutation in TEX14 Causes Human Non-Obstructive Azoospermia by Disrupting the Assembly of Intercellular Bridges.,2025,10.1111/cge.14783,https://pubmed.ncbi.nlm.nih.gov/40492599/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,39331878,Single nucleotide polymorphisms of CFAP43 and TEX14 associated with idiopathic male infertility in a Vietnamese population.,2024,10.1097/md.0000000000039839,https://pubmed.ncbi.nlm.nih.gov/39331878/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,39731187,YY1 drives PARP1 expression essential for PARylation of NONO in mRNA maturation during neuroblastoma progression.,2024,10.1186/s12967-024-05956-4,https://pubmed.ncbi.nlm.nih.gov/39731187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,39809819,Networks of pre-diagnostic circulating RNA in testicular germ cell tumour.,2025,10.1038/s41598-024-84484-z,https://pubmed.ncbi.nlm.nih.gov/39809819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,37409705,Inhibition mechanism of testis-expressed gene 14 (TEX14) in cytokinetic abscission: Well-tempered metadynamics simulation studies.,2023,10.1063/5.0153799,https://pubmed.ncbi.nlm.nih.gov/37409705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,37296437,Testis cell pyroptosis mediated by CASP1 and CASP4: possible sertoli cell-only syndrome pathogenesis.,2023,10.1186/s12958-023-01101-w,https://pubmed.ncbi.nlm.nih.gov/37296437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,37039784,Disrupted intercellular bridges and spermatogenesis in fatty acyl-CoA reductase 1 knockout mice: A new model of ether lipid deficiency.,2023,10.1096/fj.202201848r,https://pubmed.ncbi.nlm.nih.gov/37039784/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,37594251,Scrutinizing the human TEX genes in the context of human male infertility.,2024,10.1111/andr.13511,https://pubmed.ncbi.nlm.nih.gov/37594251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,36386800,Identification of genes related to sexual differentiation and sterility in embryonic gonads of Mule ducks by transcriptome analysis.,2022,10.3389/fgene.2022.1037810,https://pubmed.ncbi.nlm.nih.gov/36386800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,36230452,F1 Male Sterility in Cattle-Yak Examined through Changes in Testis Tissue and Transcriptome Profiles.,2022,10.3390/ani12192711,https://pubmed.ncbi.nlm.nih.gov/36230452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,35635088,Circular RNA testis-expressed 14 overexpression induces apoptosis and suppresses migration of ox-LDL-stimulated vascular smooth muscle cells via regulating the microRNA 6509-3p/thanatos-associated domain-containing apoptosis-associated protein 1 axis.,2022,10.1080/21655979.2022.2070582,https://pubmed.ncbi.nlm.nih.gov/35635088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,37511189,Phosphoproteomics Reveal New Candidates in Abnormal Spermatogenesis of Pseudomales in Cynoglossus semilaevis.,2023,10.3390/ijms241411430,https://pubmed.ncbi.nlm.nih.gov/37511189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,39843174,Genetic Testing for Monogenic Forms of Male Infertility Contributes to the Clinical Diagnosis of Men with Severe Idiopathic Male Infertility.,2025,10.5534/wjmh.240149,https://pubmed.ncbi.nlm.nih.gov/39843174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,36017582,Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia.,2022,10.1111/andr.13269,https://pubmed.ncbi.nlm.nih.gov/36017582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,29932616,"Expression analysis of genes encoding TEX11, TEX12, TEX14 and TEX15 in testis tissues of men with non-obstructive azoospermia.",2018,10.5935/1518-0557.20180030,https://pubmed.ncbi.nlm.nih.gov/29932616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,22719986,Characterization of spermatogonial stem cells lacking intercellular bridges and genetic replacement of a mutation in spermatogonial stem cells.,2012,10.1371/journal.pone.0038914,https://pubmed.ncbi.nlm.nih.gov/22719986/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,30619476,Putative Loci Causing Early Embryonic Mortality in Duroc Swine.,2018,10.3389/fgene.2018.00655,https://pubmed.ncbi.nlm.nih.gov/30619476/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,19542363,Gene expression profiling and real-time PCR analyses identify novel potential cancer-testis antigens in multiple myeloma.,2009,10.4049/jimmunol.0803298,https://pubmed.ncbi.nlm.nih.gov/19542363/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,23666239,Meta-analysis identifies four new loci associated with testicular germ cell tumor.,2013,10.1038/ng.2634,https://pubmed.ncbi.nlm.nih.gov/23666239/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,28206990,A familial study of azoospermic men identifies three novel causative mutations in three new human azoospermia genes.,2017,10.1038/gim.2016.225,https://pubmed.ncbi.nlm.nih.gov/28206990/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX14,ENSG00000121101,CTA,11279525,An abundance of X-linked genes expressed in spermatogonia.,2001,10.1038/86927,https://pubmed.ncbi.nlm.nih.gov/11279525/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,40586170,The TEX15 DUF3715 domain is required for retrotransposon silencing and male fertility†.,2025,10.1093/biolre/ioaf142,https://pubmed.ncbi.nlm.nih.gov/40586170/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,40438407,Genome editing in mouse spermatogonial stem cell lines targeting the Tex15 gene using CRISPR/Cas9.,2025,10.3389/fvets.2025.1599598,https://pubmed.ncbi.nlm.nih.gov/40438407/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,37234866,Genomic study of TEX15 variants: prevalence and allelic heterogeneity in men with spermatogenic failure.,2023,10.3389/fgene.2023.1134849,https://pubmed.ncbi.nlm.nih.gov/37234866/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,41784387,Positive Selection Targeted Primate Genes that Encode Transposable Element Repressors.,2026,10.1093/gbe/evag059,https://pubmed.ncbi.nlm.nih.gov/41784387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,38958533,HSF5 Deficiency Causes Male Infertility Involving Spermatogenic Arrest at Meiotic Prophase I in Humans and Mice.,2024,10.1002/advs.202402412,https://pubmed.ncbi.nlm.nih.gov/38958533/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,36589743,Contribution of TEX15 genetic variants to the risk of developing severe non-obstructive oligozoospermia.,2022,10.3389/fcell.2022.1089782,https://pubmed.ncbi.nlm.nih.gov/36589743/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,37594251,Scrutinizing the human TEX genes in the context of human male infertility.,2024,10.1111/andr.13511,https://pubmed.ncbi.nlm.nih.gov/37594251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,35103426,"Correlation of Novel Single Nucleotide Polymorphisms ofUSP26, TEX15, and TNP2 Genes with Male Infertility in North West of Iran.",2022,10.22074/ijfs.2021.521138.1058,https://pubmed.ncbi.nlm.nih.gov/35103426/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,37433650,The DUF3715 domain has a conserved role in RNA-directed transposon silencing.,2023,10.1261/rna.079693.123,https://pubmed.ncbi.nlm.nih.gov/37433650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,32381626,TEX15 associates with MILI and silences transposable elements in male germ cells.,2020,10.1101/gad.335489.119,https://pubmed.ncbi.nlm.nih.gov/32381626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,36230452,F1 Male Sterility in Cattle-Yak Examined through Changes in Testis Tissue and Transcriptome Profiles.,2022,10.3390/ani12192711,https://pubmed.ncbi.nlm.nih.gov/36230452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,32719317,TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.,2020,10.1038/s41467-020-17372-5,https://pubmed.ncbi.nlm.nih.gov/32719317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,39843174,Genetic Testing for Monogenic Forms of Male Infertility Contributes to the Clinical Diagnosis of Men with Severe Idiopathic Male Infertility.,2025,10.5534/wjmh.240149,https://pubmed.ncbi.nlm.nih.gov/39843174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,29932616,"Expression analysis of genes encoding TEX11, TEX12, TEX14 and TEX15 in testis tissues of men with non-obstructive azoospermia.",2018,10.5935/1518-0557.20180030,https://pubmed.ncbi.nlm.nih.gov/29932616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,32060041,RNA sequencing profiles and diagnostic signatures linked with response to ramucirumab in gastric cancer.,2020,10.1101/mcs.a004945,https://pubmed.ncbi.nlm.nih.gov/32060041/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,35217607,PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2.,2022,10.1073/pnas.2114401119,https://pubmed.ncbi.nlm.nih.gov/35217607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,32655042,Next-generation sequencing: toward an increase in the diagnostic yield in patients with apparently idiopathic spermatogenic failure.,2021,10.4103/aja.aja_25_20,https://pubmed.ncbi.nlm.nih.gov/32655042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,28303806,Case study of a patient with cryptozoospermia associated with a recessive TEX15 nonsense mutation.,2018,10.4103/1008-682x.194998,https://pubmed.ncbi.nlm.nih.gov/28303806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,28355598,Two Novel TEX15 Mutations in a Family with Nonobstructive Azoospermia.,2017,10.1159/000468934,https://pubmed.ncbi.nlm.nih.gov/28355598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,28386063,Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility.,2017,10.1038/s41598-017-00766-9,https://pubmed.ncbi.nlm.nih.gov/28386063/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,23574628,"Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene.",2013,10.1111/tan.12113,https://pubmed.ncbi.nlm.nih.gov/23574628/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,27802063,In silico analysis of candidate proteins sharing homology with Streptococcus agalactiae proteins and their role in male infertility.,2017,10.1080/19396368.2016.1243741,https://pubmed.ncbi.nlm.nih.gov/27802063/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,26199321,Exome sequencing reveals a nonsense mutation in TEX15 causing spermatogenic failure in a Turkish family.,2015,10.1093/hmg/ddv290,https://pubmed.ncbi.nlm.nih.gov/26199321/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,12704671,Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia.,2003,10.1002/ijc.11104,https://pubmed.ncbi.nlm.nih.gov/12704671/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX15,ENSG00000133863,CTA,11279525,An abundance of X-linked genes expressed in spermatogonia.,2001,10.1038/86927,https://pubmed.ncbi.nlm.nih.gov/11279525/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,40897289,"Patients with colon cancer exhibited greater TEX19 expression, controlled in vitro by epigenetic inhibitors.",2025,10.1016/j.gene.2025.149747,https://pubmed.ncbi.nlm.nih.gov/40897289/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,42724882,The prognostic value and molecular mechanisms of &lt;i&gt;Porphyromonas gingivalis&lt;/i&gt; infection-associated differentially expressed genes in oral squamous cell carcinoma.,2026,10.21037/tcr-2026-0747,https://pubmed.ncbi.nlm.nih.gov/42724882/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,38867223,TEX19 increases the levels of CDK4 and promotes breast cancer by disrupting SKP2-mediated CDK4 ubiquitination.,2024,10.1186/s12935-024-03384-4,https://pubmed.ncbi.nlm.nih.gov/38867223/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,37606876,Transcription Factor FOXA1 Facilitates Glycolysis and Proliferation of Lung Adenocarcinoma via Activation of TEX19.,2024,10.1007/s12033-023-00848-2,https://pubmed.ncbi.nlm.nih.gov/37606876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,40371706,scRNA-seq and scATAC-seq reveal that Sertoli cell mediates spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia.,2025,10.7554/elife.97958,https://pubmed.ncbi.nlm.nih.gov/40371706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,41233852,Integrating bulk and single-cell RNA sequencing analysis to reveal characterization of mechanical stimulus-related genes and prognostic signatures in breast cancer.,2025,10.1186/s13058-025-02130-6,https://pubmed.ncbi.nlm.nih.gov/41233852/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,37648546,TEX19 could function as a prognostic biomarker for prostate cancer.,2023,10.1016/j.asjsur.2023.08.076,https://pubmed.ncbi.nlm.nih.gov/37648546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,34036740,"In silico modeling of the interaction between TEX19 and LIRE1, and analysis of TEX19 gene missense SNPs.",2021,10.1002/mgg3.1707,https://pubmed.ncbi.nlm.nih.gov/34036740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,31843525,TEX19 promotes ovarian carcinoma progression and is a potential target for epitope vaccine immunotherapy.,2020,10.1016/j.lfs.2019.117171,https://pubmed.ncbi.nlm.nih.gov/31843525/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,28446200,Human germ/stem cell-specific gene TEX19 influences cancer cell proliferation and cancer prognosis.,2017,10.1186/s12943-017-0653-4,https://pubmed.ncbi.nlm.nih.gov/28446200/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,32758242,Prediction of relapse in stage I testicular germ cell tumor patients on surveillance: investigation of biomarkers.,2020,10.1186/s12885-020-07220-6,https://pubmed.ncbi.nlm.nih.gov/32758242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,26695143,Testis expressed 19 is a novel cancer-testis antigen expressed in bladder cancer.,2016,10.1007/s13277-015-4567-8,https://pubmed.ncbi.nlm.nih.gov/26695143/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,26459560,Tex19 and Sectm1 concordant molecular phylogenies support co-evolution of both eutherian-specific genes.,2015,10.1186/s12862-015-0506-y,https://pubmed.ncbi.nlm.nih.gov/26459560/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,28254886,Tex19 paralogs are new members of the piRNA pathway controlling retrotransposon suppression.,2017,10.1242/jcs.188763,https://pubmed.ncbi.nlm.nih.gov/28254886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,37160133,Thermal inkjet bioprinting drastically alters cell phenotype.,2023,10.1088/1758-5090/acd3b3,https://pubmed.ncbi.nlm.nih.gov/37160133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,22447323,Tex 19 paralogs exhibit a gonad and placenta-specific expression in the mouse.,2012,10.1262/jrd.11-047k,https://pubmed.ncbi.nlm.nih.gov/22447323/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,18096721,"Tex19, a mammalian-specific protein with a restricted expression in pluripotent stem cells and germ line.",2008,10.1634/stemcells.2007-0772,https://pubmed.ncbi.nlm.nih.gov/18096721/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,23674551,The mammalian-specific Tex19.1 gene plays an essential role in spermatogenesis and placenta-supported development.,2013,10.1093/humrep/det129,https://pubmed.ncbi.nlm.nih.gov/23674551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,21103378,"The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule pathway, stabilizes Tex19.1 during spermatogenesis.",2010,10.1371/journal.pone.0014017,https://pubmed.ncbi.nlm.nih.gov/21103378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX19,ENSG00000182459,CTA,18160741,Molecular profiling of the human testis reveals stringent pathway-specific regulation of RNA expression following gonadotropin suppression and progestogen treatment.,2008,10.2164/jandrol.107.004168,https://pubmed.ncbi.nlm.nih.gov/18160741/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX36,ENSG00000175018,CTA,32561905,CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity.,2020,10.1093/biolre/ioaa084,https://pubmed.ncbi.nlm.nih.gov/32561905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX38,ENSG00000186118,CTA,40783453,Disruption of TEX38 impairs sperm morphogenesis and the migration of sperm into the oviduct.,2025,10.1038/s42003-025-08644-1,https://pubmed.ncbi.nlm.nih.gov/40783453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX38,ENSG00000186118,CTA,41420860,Biogenesis and migration of the sperm cytoplasmic droplet require ARRDC5 and TEX38.,2026,10.1016/j.celrep.2025.116731,https://pubmed.ncbi.nlm.nih.gov/41420860/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX38,ENSG00000186118,CTA,40030029,TEX38 localizes ZDHHC19 to the plasma membrane and regulates sperm head morphogenesis in mice.,2025,10.1073/pnas.2417943122,https://pubmed.ncbi.nlm.nih.gov/40030029/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX38,ENSG00000186118,CTA,37882717,[Production and application of rabbit polyclonal antibody against mouse testis expressed 38 (TEX38)].,2023,,https://pubmed.ncbi.nlm.nih.gov/37882717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX38,ENSG00000186118,CTA,37083227,Deciphering the Molecular Characteristics of Human Idiopathic Nonobstructive Azoospermia from the Perspective of Germ Cells.,2023,10.1002/advs.202206852,https://pubmed.ncbi.nlm.nih.gov/37083227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX38,ENSG00000186118,CTA,37549510,Integrated molecular-network analysis reveals infertility-associated key genes and transcription factors in the non-obstructive azoospermia.,2023,10.1016/j.ejogrb.2023.07.023,https://pubmed.ncbi.nlm.nih.gov/37549510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX38,ENSG00000186118,CTA,36455238,Construction of a prognostic model for lung squamous cell carcinoma based on immune-related genes.,2023,10.1093/carcin/bgac098,https://pubmed.ncbi.nlm.nih.gov/36455238/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX38,ENSG00000186118,CTA,29610366,Exome chip analyses identify genes affecting mortality after HLA-matched unrelated-donor blood and marrow transplantation.,2018,10.1182/blood-2017-11-817973,https://pubmed.ncbi.nlm.nih.gov/29610366/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX44,ENSG00000177673,CTA,42133262,"TEX44 deficiency induces asthenoteratozoospermia by disrupting sperm axonemal integrity and mitochondrial sheath assembly, and ICSI enables successful fertility rescue.",2026,10.1007/s10815-026-03901-6,https://pubmed.ncbi.nlm.nih.gov/42133262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX44,ENSG00000177673,CTA,40849303,The TEX44-CPT1B axis regulates mitochondrial sheath assembly and fatty acid oxidation in sperm.,2025,10.1038/s41467-025-63280-x,https://pubmed.ncbi.nlm.nih.gov/40849303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX44,ENSG00000177673,CTA,38750428,The lack of Tex44 causes severe subfertility with flagellar abnormalities in male mice.,2024,10.1186/s11658-024-00587-5,https://pubmed.ncbi.nlm.nih.gov/38750428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX44,ENSG00000177673,CTA,34817046,RNA-binding protein with serine-rich domain 1 regulates microsatellite instability of uterine corpus endometrial adenocarcinoma.,2021,10.6061/clinics/2021/e3318,https://pubmed.ncbi.nlm.nih.gov/34817046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX44,ENSG00000177673,CTA,26168773,Human Spermatozoa as a Model for Detecting Missing Proteins in the Context of the Chromosome-Centric Human Proteome Project.,2015,10.1021/acs.jproteome.5b00170,https://pubmed.ncbi.nlm.nih.gov/26168773/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX46,ENSG00000227868,CTA,38516277,Tex46 knockout male mice are sterile secondary to sperm head malformations and failure to penetrate through the zona pellucida.,2024,10.1093/pnasnexus/pgae108,https://pubmed.ncbi.nlm.nih.gov/38516277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX47,ENSG00000164645,CTA,31932510,"LAX28 is required for the stable assembly of the inner dynein arm f complex, and the tether and tether head complex in Leishmania flagella.",2020,10.1242/jcs.239855,https://pubmed.ncbi.nlm.nih.gov/31932510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX47,ENSG00000164645,CTA,34529728,Genetic differentiation of mainland-island sheep of Greece: Implications for identifying candidate genes for long-term local adaptation.,2021,10.1371/journal.pone.0257461,https://pubmed.ncbi.nlm.nih.gov/34529728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX51,ENSG00000237524,CTA,41233479,Spermatozoa lacking TEX51 display hypofertility and defects in morphology.,2025,10.1038/s42003-025-08937-5,https://pubmed.ncbi.nlm.nih.gov/41233479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX51,ENSG00000237524,CTA,40572022,Mouse genome engineering uncovers 18 genes dispensable for male reproduction.,2026,10.1111/andr.70088,https://pubmed.ncbi.nlm.nih.gov/40572022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX51,ENSG00000237524,CTA,42072359,Integrative Whole-Genome and Epigenome Profiling of cfDNA in Familial Prostate Cancer: Insights from a Pilot Study.,2026,10.3390/biomedicines14040818,https://pubmed.ncbi.nlm.nih.gov/42072359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX51,ENSG00000237524,CTA,33145279,Genetic polymorphisms in neuroendocrine disorder-related candidate genes associated with pre-pregnancy obesity in gestational diabetes mellitus patients by using a stratification approach.,2020,10.21037/atm-20-1579,https://pubmed.ncbi.nlm.nih.gov/33145279/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LX,ENSG00000153779,CTA,33517372,"A comprehensive survey for human transcription factors on expression, regulation, interaction, phenotype and cancer survival.",2021,10.1093/bib/bbab002,https://pubmed.ncbi.nlm.nih.gov/33517372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LX,ENSG00000153779,CTA,36510989,Regulation of long non-coding RNAs XIST and ROR induced by homeodomain protein TGIF2LX in colorectal cancer.,2022,10.4103/jcrt.jcrt_869_20,https://pubmed.ncbi.nlm.nih.gov/36510989/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LX,ENSG00000153779,CTA,27699219,Profiling cancer testis antigens in non-small-cell lung cancer.,2016,10.1172/jci.insight.86837,https://pubmed.ncbi.nlm.nih.gov/27699219/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LX,ENSG00000153779,CTA,28843229,"Homeodomain Protein Transforming Growth Factor Beta-Induced Factor 2 Like, X-Linked Function in Colon Adenocarcinoma Cells",2017,10.22034/apjcp.2017.18.8.2101,https://pubmed.ncbi.nlm.nih.gov/28843229/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LX,ENSG00000153779,CTA,29960902,In vivo identification of novel TGIF2LX target genes in colorectal adenocarcinoma using the cDNA-AFLP method.,2018,10.1016/j.ajg.2018.05.001,https://pubmed.ncbi.nlm.nih.gov/29960902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LX,ENSG00000153779,CTA,26171336,Induction of Apoptosis and Growth Suppression by Homeobox Gene TGIFLX in Prostate Cancer Cell Line Lncap.,2013,,https://pubmed.ncbi.nlm.nih.gov/26171336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LX,ENSG00000153779,CTA,21958027,Differential roles of TGIF family genes in mammalian reproduction.,2011,10.1186/1471-213x-11-58,https://pubmed.ncbi.nlm.nih.gov/21958027/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LX,ENSG00000153779,CTA,27309477,"Transforming Growth Factor Beta-Induced Factor 2-Linked X (TGIF2LX) Regulates Two Morphogenesis Genes, Nir1 and Nir2 in Human Colorectal.",2016,,https://pubmed.ncbi.nlm.nih.gov/27309477/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LX,ENSG00000153779,CTA,24442537,Differential expression of human homeodomain TGIFLX in brain tumor cell lines.,2013,,https://pubmed.ncbi.nlm.nih.gov/24442537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LX,ENSG00000153779,CTA,18384077,Association of TGIFLX/Y mRNA expression with azoospermia in infertile men.,2008,10.1002/mrd.20906,https://pubmed.ncbi.nlm.nih.gov/18384077/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LX,ENSG00000153779,CTA,32266521,A genome-wide association study implicates the BMP7 locus as a risk factor for nonsyndromic metopic craniosynostosis.,2020,10.1007/s00439-020-02157-z,https://pubmed.ncbi.nlm.nih.gov/32266521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LX,ENSG00000153779,CTA,18721782,Transgenic analyses of TGIF family proteins in Drosophila imply their role in cell growth.,2008,10.1016/s1673-8527(08)60063-6,https://pubmed.ncbi.nlm.nih.gov/18721782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LX,ENSG00000153779,CTA,12226713,The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon.,2002,10.1007/s00335-002-3010-9,https://pubmed.ncbi.nlm.nih.gov/12226713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LX,ENSG00000153779,CTA,18663611,Association of TGIFLX/Y mRNA expression with prostate cancer.,2009,10.1007/s12032-008-9086-7,https://pubmed.ncbi.nlm.nih.gov/18663611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LX,ENSG00000153779,CTA,15238536,Rapid evolution of mammalian X-linked testis-expressed homeobox genes.,2004,10.1534/genetics.103.025072,https://pubmed.ncbi.nlm.nih.gov/15238536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LX,ENSG00000153779,CTA,21316664,Copy number variants on the X chromosome in women with primary ovarian insufficiency.,2011,10.1016/j.fertnstert.2011.01.018,https://pubmed.ncbi.nlm.nih.gov/21316664/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMCO2,ENSG00000188800,CTA,41722335,Effects of a mutation in the transmembrane and coiled-coil domains 2 gene on ovarian function and reproductive aging.,2026,10.1016/j.maturitas.2026.108885,https://pubmed.ncbi.nlm.nih.gov/41722335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMCO2,ENSG00000188800,CTA,40572022,Mouse genome engineering uncovers 18 genes dispensable for male reproduction.,2026,10.1111/andr.70088,https://pubmed.ncbi.nlm.nih.gov/40572022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMCO2,ENSG00000188800,CTA,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMCO2,ENSG00000188800,CTA,33190538,Orchestrating the expression levels of sperm mRNAs reveals CCDC174 as an important determinant of semen quality and bull fertility.,2021,10.1080/19396368.2020.1836286,https://pubmed.ncbi.nlm.nih.gov/33190538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMCO5A,ENSG00000166069,CTA,42098631,Integrated transcriptomic and proteomic analyses reveal muscle fiber-type transformation in meat rabbits.,2026,10.1186/s12864-026-12906-5,https://pubmed.ncbi.nlm.nih.gov/42098631/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMCO5A,ENSG00000166069,CTA,31393949,Mouse TMCO5 is localized to the manchette microtubules involved in vesicle transfer in the elongating spermatids.,2019,10.1371/journal.pone.0220917,https://pubmed.ncbi.nlm.nih.gov/31393949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMCO5A,ENSG00000166069,CTA,30632224,"A membrane protein, TMCO5A, has a close relationship with manchette microtubules in rat spermatids during spermiogenesis.",2019,10.1002/mrd.23108,https://pubmed.ncbi.nlm.nih.gov/30632224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMCO5A,ENSG00000166069,CTA,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMCO5A,ENSG00000166069,CTA,36553445,Genomic Analysis of Gastrointestinal Parasite Resistance in Akkaraman Sheep.,2022,10.3390/genes13122177,https://pubmed.ncbi.nlm.nih.gov/36553445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM210,ENSG00000185863,CTA,34290169,CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice.,2022,10.4103/aja.aja_63_21,https://pubmed.ncbi.nlm.nih.gov/34290169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM225,ENSG00000204300,CTA,38246484,TMEM225 Is Essential for Sperm Maturation and Male Fertility by Modifying Protein Distribution of Sperm in Mice.,2024,10.1016/j.mcpro.2024.100720,https://pubmed.ncbi.nlm.nih.gov/38246484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM225,ENSG00000204300,CTA,25605614,TMEM225: a possible protein phosphatase 1γ2 (PP1γ2) regulator localizes to the equatorial segment in mouse spermatozoa.,2015,10.1002/mrd.22453,https://pubmed.ncbi.nlm.nih.gov/25605614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM225,ENSG00000204300,CTA,30362892,Expression analysis of a panel of cancer-testis antigens in bladder cancer.,2018,10.2217/pme-2018-0049,https://pubmed.ncbi.nlm.nih.gov/30362892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM225,ENSG00000204300,CTA,20979528,Localization and characterization of rat transmembrane protein 225 specifically expressed in testis.,2011,10.1089/dna.2010.1048,https://pubmed.ncbi.nlm.nih.gov/20979528/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM225,ENSG00000204300,CTA,24012201,Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis.,2013,10.1016/j.fertnstert.2013.07.1999,https://pubmed.ncbi.nlm.nih.gov/24012201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM270,ENSG00000175877,CTA,39457566,Associations between Disc Hemorrhage and Primary Open-Angle Glaucoma Based on Genome-Wide Association and Mendelian Randomization Analyses.,2024,10.3390/biomedicines12102253,https://pubmed.ncbi.nlm.nih.gov/39457566/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM270,ENSG00000175877,CTA,30568834,Array CGH - A Powerful Tool in Molecular Diagnostic of Pathogenic Microdeletions - Williams-Beuren Syndrome - A Case Report.,2016,10.12865/chsj.42.02.14,https://pubmed.ncbi.nlm.nih.gov/30568834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM270,ENSG00000175877,CTA,32351322,Identification of Hub Genes Related to Carcinogenesis and Prognosis in Colorectal Cancer Based on Integrated Bioinformatics.,2020,10.1155/2020/5934821,https://pubmed.ncbi.nlm.nih.gov/32351322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM270,ENSG00000175877,CTA,24012201,Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis.,2013,10.1016/j.fertnstert.2013.07.1999,https://pubmed.ncbi.nlm.nih.gov/24012201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM270,ENSG00000175877,CTA,17624924,Androgen receptor-mediated repression of novel target genes.,2007,10.1002/pros.20623,https://pubmed.ncbi.nlm.nih.gov/17624924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS12,ENSG00000186452,CTA,40764777,Rescue of male infertility by human PRSS55 in transgenic mice establishes a contraceptive research model.,2025,10.1038/s41598-025-09604-9,https://pubmed.ncbi.nlm.nih.gov/40764777/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS12,ENSG00000186452,CTA,39208330,"Differential expression and regulation of ADAD1, DMRTC2, PRSS54, SYCE1, SYCP1, TEX101, TEX48, and TMPRSS12 gene profiles in colon cancer tissues and their in vitro response to epigenetic drugs.",2024,10.1371/journal.pone.0307724,https://pubmed.ncbi.nlm.nih.gov/39208330/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS12,ENSG00000186452,CTA,41985786,PRSS23 promotes ovarian cancer peritoneal dissemination independent of protease activity.,2026,10.1016/j.jbc.2026.111450,https://pubmed.ncbi.nlm.nih.gov/41985786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS12,ENSG00000186452,CTA,35547804,TMPRSS12 Functions in Meiosis and Spermiogenesis and Is Required for Male Fertility in Mice.,2022,10.3389/fcell.2022.757042,https://pubmed.ncbi.nlm.nih.gov/35547804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS12,ENSG00000186452,CTA,32529245,Tmprss12 is required for sperm motility and uterotubal junction migration in mice†.,2020,10.1093/biolre/ioaa060,https://pubmed.ncbi.nlm.nih.gov/32529245/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS12,ENSG00000186452,CTA,32649023,COVID-19 and human spermatozoa-Potential risks for infertility and sexual transmission?,2021,10.1111/andr.12859,https://pubmed.ncbi.nlm.nih.gov/32649023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS12,ENSG00000186452,CTA,27707927,TMPRSS12 Is an Activating Protease for Subtype B Avian Metapneumovirus.,2016,10.1128/jvi.01567-16,https://pubmed.ncbi.nlm.nih.gov/27707927/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS12,ENSG00000186452,CTA,23436708,Scanning of novel cancer/testis proteins by human testis proteomic analysis.,2013,10.1002/pmic.201200489,https://pubmed.ncbi.nlm.nih.gov/23436708/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS12,ENSG00000186452,CTA,31180552,Characterization of a prognostic four‑gene methylation signature associated with radiotherapy for head and neck squamous cell carcinoma.,2019,10.3892/mmr.2019.10294,https://pubmed.ncbi.nlm.nih.gov/31180552/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,41915740,ASB9 promotes ubiquitin-mediated degradation of TNP2 to facilitate histone-to-protamine transition in humans and mice.,2026,10.1073/pnas.2522270123,https://pubmed.ncbi.nlm.nih.gov/41915740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,42432487,Profiling chromatin accessibility responses to seasonal heat stress in Angora rabbit testes.,2026,10.1186/s12864-026-13133-8,https://pubmed.ncbi.nlm.nih.gov/42432487/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,41866036,PRAMEL12 orchestrates spermiogenesis to ensure male fertility in mice.,2026,10.1016/j.jbc.2026.111392,https://pubmed.ncbi.nlm.nih.gov/41866036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,41793517,Dysregulated methylation of the human BOLL promoter hinders germ cell development from spermatogonia to spermatids.,2026,10.1007/s11033-026-11633-0,https://pubmed.ncbi.nlm.nih.gov/41793517/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,39688669,Coevolution and Adaptation of Transition Nuclear Proteins and Protamines in Naturally Ascrotal Mammals Support the Black Queen Hypothesis.,2024,10.1093/gbe/evae260,https://pubmed.ncbi.nlm.nih.gov/39688669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,37995753,"Polymorphisms and expression levels of TNP2, SYCP3, and AZFa genes in patients with azoospermia.",2023,10.5653/cerm.2023.06219,https://pubmed.ncbi.nlm.nih.gov/37995753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,40938846,Gene expression alterations in testicular biopsies from males with spermatogenesis arrest identified by transcriptome analysis.,2025,10.1371/journal.pone.0332025,https://pubmed.ncbi.nlm.nih.gov/40938846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,41490753,Male reproductive impairment linked to occupational ionizing radiation exposure in radiology workers.,2026,10.1016/j.reprotox.2026.109160,https://pubmed.ncbi.nlm.nih.gov/41490753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,39028130,Adverse Effects of Nicotine on Human Sperm Nuclear Proteins.,2025,10.5534/wjmh.240072,https://pubmed.ncbi.nlm.nih.gov/39028130/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,34979062,Dynamic Expression and Chromatin Incorporation of ACT and CREM Transcription Factors in Testis Tissues of Infertile Men.,2021,10.22074/cellj.2021.7634,https://pubmed.ncbi.nlm.nih.gov/34979062/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,37694540,The anti-spermatogenic activity of nanoliposomes loaded with Heracleum persicum phenolic compounds in Balb/C mice.,2023,10.1002/bab.2511,https://pubmed.ncbi.nlm.nih.gov/37694540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,36241908,"VASA protein and gene expression analysis of human non-obstructive azoospermia and normal by immunohistochemistry, immunocytochemistry, and bioinformatics analysis.",2022,10.1038/s41598-022-22137-9,https://pubmed.ncbi.nlm.nih.gov/36241908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,35103426,"Correlation of Novel Single Nucleotide Polymorphisms ofUSP26, TEX15, and TNP2 Genes with Male Infertility in North West of Iran.",2022,10.22074/ijfs.2021.521138.1058,https://pubmed.ncbi.nlm.nih.gov/35103426/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,38320369,Ursonic acid attenuates spermatogenesis in oligozoospermia mice through inhibiting ferroptosis.,2024,10.1016/j.bioorg.2024.107174,https://pubmed.ncbi.nlm.nih.gov/38320369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,34235877,"Spermatozoa retrieval in azoospermia and expression profile of JMJD1A, TNP2, and PRM2 in a subset of the Karachi population.",2021,10.1111/andr.13076,https://pubmed.ncbi.nlm.nih.gov/34235877/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,40716245,Systematic review and evidence-based classification of differentially expressed mRNA in human spermatozoa: insights to improve the diagnosis and prognosis of male infertility.,2025,10.1016/j.rbmo.2025.104993,https://pubmed.ncbi.nlm.nih.gov/40716245/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,32693775,Sub-fertility in crossbred bulls: deciphering testicular level transcriptomic alterations between zebu (Bos indicus) and crossbred (Bos taurus x Bos indicus) bulls.,2020,10.1186/s12864-020-06907-1,https://pubmed.ncbi.nlm.nih.gov/32693775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,36228521,"Polygenic co-expression changes the testis growth, hormone secretion and spermatogenesis to prompt puberty in Hu sheep.",2022,10.1016/j.theriogenology.2022.09.025,https://pubmed.ncbi.nlm.nih.gov/36228521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,34679903,"Search for Associations of FSHR, INHA, INHAB, PRL, TNP2 and SPEF2 Genes Polymorphisms with Semen Quality in Russian Holstein Bulls (Pilot Study).",2021,10.3390/ani11102882,https://pubmed.ncbi.nlm.nih.gov/34679903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,31692026,Anticancer properties of green-synthesised zinc oxide nanoparticles using Hyssopus officinalis extract on prostate carcinoma cells and its effects on testicular damage and spermatogenesis in Balb/C mice.,2020,10.1111/and.13450,https://pubmed.ncbi.nlm.nih.gov/31692026/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,34494233,Cryoprotective Effect of Pentoxifylline on Spermatogonial Stem Cell During Transplantation into Azoospermic Torsion Mouse Model.,2022,10.1007/s43032-021-00729-6,https://pubmed.ncbi.nlm.nih.gov/34494233/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,35464478,"A Genome-Wide Association Study for Tolerance to Paratuberculosis Identifies Candidate Genes Involved in DNA Packaging, DNA Damage Repair, Innate Immunity, and Pathogen Persistence.",2022,10.3389/fimmu.2022.820965,https://pubmed.ncbi.nlm.nih.gov/35464478/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,30551142,Cytological and molecular aspects of the ageing sperm.,2019,10.1093/humrep/dey357,https://pubmed.ncbi.nlm.nih.gov/30551142/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,24711891,Melatonin improves spermatogonial stem cells transplantation efficiency in azoospermic mice.,2014,,https://pubmed.ncbi.nlm.nih.gov/24711891/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,23721730,"Titanium dioxide nanoparticle-induced testicular damage, spermatogenesis suppression, and gene expression alterations in male mice.",2013,10.1016/j.jhazmat.2013.04.046,https://pubmed.ncbi.nlm.nih.gov/23721730/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,30087569,ISEcp1-mediated transposition of chromosome-borne blaCMY-2 into an endogenous ColE1-like plasmid in Escherichia coli.,2018,10.2147/idr.s159345,https://pubmed.ncbi.nlm.nih.gov/30087569/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP2,ENSG00000178279,CTA,9809674,Expression of mRNA and protein of nucleoproteins during human spermiogenesis.,1998,10.1093/molehr/4.10.939,https://pubmed.ncbi.nlm.nih.gov/9809674/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPD52L3,ENSG00000170777,CTA,35432753,"Free fatty acids, glucose, and insulin in type 2 diabetes mellitus.",2022,10.4239/wjd.v13.i3.275,https://pubmed.ncbi.nlm.nih.gov/35432753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPD52L3,ENSG00000170777,CTA,16631610,A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins.,2006,10.1016/j.bbrc.2006.03.208,https://pubmed.ncbi.nlm.nih.gov/16631610/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,41881971,"TPTE, a testis-specific PTEN family member, drives spermatogenesis via PI(4,5)P&lt;sub&gt;2&lt;/sub&gt; synthesis.",2026,10.1038/s41419-026-08614-3,https://pubmed.ncbi.nlm.nih.gov/41881971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,42888346,"A genome-wide association study of cognitive impairment in a Chinese cohort of 1,040 individuals.",2026,10.1007/s00439-026-02887-6,https://pubmed.ncbi.nlm.nih.gov/42888346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,40645662,Shared epitopes create safety and efficacy concerns in several cancer vaccines.,2025,10.1136/jitc-2025-012217,https://pubmed.ncbi.nlm.nih.gov/40645662/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,38546751,"Overexpression of Transmembrane Phosphatase with Tensin homology (TPTE) in prostate cancer is clinically significant, suggesting its potential as a valuable biomarker.",2024,10.1007/s00432-024-05694-6,https://pubmed.ncbi.nlm.nih.gov/38546751/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,41742508,Accuracy of 6-lead electrocardiography in identifying subclinical hypertrophic cardiomyopathy in cats.,2026,10.1093/jvimsj/aalaf009,https://pubmed.ncbi.nlm.nih.gov/41742508/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,40481591,DNA methylation in monozygotic twins discordant for acute lymphoblastic leukemia: a case report and systematic review.,2025,10.1186/s13148-025-01906-z,https://pubmed.ncbi.nlm.nih.gov/40481591/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,42460311,Genomic landscape of Mexican patients with maturity onset diabetes of the young: beyond mutations in MODY-known genes.,2026,10.3389/fendo.2026.1887861,https://pubmed.ncbi.nlm.nih.gov/42460311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,40324474,The T-wave peak-end to QT ratio is prolonged and minimally influenced by RR interval in Doberman Pinschers with subclinical dilated cardiomyopathy.,2025,10.2460/javma.25.02.0097,https://pubmed.ncbi.nlm.nih.gov/40324474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,38890171,"Expression of the tumor antigens NY-ESO-1, tyrosinase, MAGE-A3, and TPTE in pediatric and adult melanoma: a retrospective case control study.",2024,10.1007/s00428-024-03846-0,https://pubmed.ncbi.nlm.nih.gov/38890171/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,41684564,Electrocardiographic repolarization parameters in children with arrhythmias and excessive body weight.,2025,10.5114/aoms/176675,https://pubmed.ncbi.nlm.nih.gov/41684564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,42634517,"Metformin Mitigates Hemodynamic, Autonomic, Oxidative, and Inflammatory Dysregulation in L-NAME-Induced Preeclampsia.",2026,10.2174/0113816128463168260724045843,https://pubmed.ncbi.nlm.nih.gov/42634517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,40230406,"Effect of dapagliflozin, a sodium-glucose co-transporter 2 inhibitor, on ventricular repolarization electrocardiographic parameters in type 2 diabetes patients: DAPA - ECG study.",2025,10.3389/fcdhc.2025.1537005,https://pubmed.ncbi.nlm.nih.gov/40230406/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,38997874,The assessment of adolescent obesity's effects on ventricular repolarization.,2024,10.1016/j.jelectrocard.2024.06.045,https://pubmed.ncbi.nlm.nih.gov/38997874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,40594940,Diagnostic accuracy of wearable ECG and assessment of ventricular repolarization and its cardiovascular risks post cold stress.,2025,10.1038/s41598-025-08569-z,https://pubmed.ncbi.nlm.nih.gov/40594940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,39925699,Impact of Different Metabolic Indicators on Ventricular Repolarization Indices in Obese Children: A Case Control Study.,2025,10.1177/11795514251316248,https://pubmed.ncbi.nlm.nih.gov/39925699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,37935110,Prediction of breath-holding spells based on electrocardiographic parameters using machine-learning model.,2024,10.1111/anec.13093,https://pubmed.ncbi.nlm.nih.gov/37935110/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,38105780,The Effects of Methylphenidate on Ventricular Repolarization Parameters in Children with Attention-Deficit Hyperactivity Disorder.,2023,10.5152/alphapsychiatry.2023.231185,https://pubmed.ncbi.nlm.nih.gov/38105780/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,39014414,Effect of long-term use of antipsychotics on the ventricular repolarization index.,2024,10.1186/s12888-024-05947-1,https://pubmed.ncbi.nlm.nih.gov/39014414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,39422584,The lncRNA TPTEP1 suppresses PI3K/AKT signalling and inhibits ovarian cancer progression by interacting with PTBP1.,2024,10.1111/jcmm.70106,https://pubmed.ncbi.nlm.nih.gov/39422584/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,41703583,Multimodal deep learning for survival prediction and biomarker discovery in non-small cell lung cancer.,2026,10.1186/s13040-026-00522-8,https://pubmed.ncbi.nlm.nih.gov/41703583/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,41189577,Effect of early adaptive servoventilation on cardiac repolarisation in patients with myocardial infarction and sleep disordered breathing: an ancillary analysis of the randomised controlled trial TEAM-ASV I.,2025,10.1183/23120541.01341-2024,https://pubmed.ncbi.nlm.nih.gov/41189577/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,37910266,Effect of Remifentanil on the Tpeak-Tend Interval During Electroconvulsive Therapy.,2024,10.1007/s12325-023-02713-9,https://pubmed.ncbi.nlm.nih.gov/37910266/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,39746274,Unveiling the role of ACTL6A in uveal melanoma metastasis and immune microenvironment.,2025,10.1016/j.intimp.2024.113841,https://pubmed.ncbi.nlm.nih.gov/39746274/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,40287662,Temporal dynamics and clinical correlates of ischemic J waves in the early phase of acute myocardial infarction.,2025,10.1186/s12872-025-04766-w,https://pubmed.ncbi.nlm.nih.gov/40287662/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,36548004,T-Peak to T-End Interval for Prediction of Positive Response to Ajmaline Challenge Test in Suspected Brugada Syndrome Patients.,2022,10.3390/medsci10040069,https://pubmed.ncbi.nlm.nih.gov/36548004/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,38852685,Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone.,2024,10.1016/j.vascn.2024.107527,https://pubmed.ncbi.nlm.nih.gov/38852685/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,34271131,Repolarization and ventricular arrhythmia during targeted temperature management post cardiac arrest.,2021,10.1016/j.resuscitation.2021.07.004,https://pubmed.ncbi.nlm.nih.gov/34271131/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,39077099,The Impact of Coronary Sinus Reducer on Arrhythmic Properties in Patients with Refractory Angina.,2023,10.31083/j.rcm2412368,https://pubmed.ncbi.nlm.nih.gov/39077099/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,39267805,Comparison of electrocardiogram parameters and echocardiographic response between distinct left bundle branch area pacing modes in heart failure patients.,2024,10.3389/fcvm.2024.1441241,https://pubmed.ncbi.nlm.nih.gov/39267805/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,35005792,"Ventricular repolarization heterogeneity in patients with COVID-19: Original data, systematic review, and meta-analysis.",2022,10.1002/clc.23767,https://pubmed.ncbi.nlm.nih.gov/35005792/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,33956361,The impact of hydroxychloroquine-azithromycin combination on Tpeak-to-end and Tpeak-to-end/QT ratio during a short treatment course.,2021,10.1111/anec.12846,https://pubmed.ncbi.nlm.nih.gov/33956361/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE,ENSG00000274391,CTA,10598804,"A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y.",1999,10.1007/s004390051122,https://pubmed.ncbi.nlm.nih.gov/10598804/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,42306238,A Phase 2 Study of the Safety and Tolerability of Treprostinil Palmitil Inhalation Powder in Patients With Pulmonary Hypertension Associated With Interstitial Lung Disease.,2026,10.1002/pul2.70322,https://pubmed.ncbi.nlm.nih.gov/42306238/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,42857300,Effects of geometric isomerism and regioisomerism on photophysical properties of iridium(iii) complexes.,2026,10.1039/d6ra07317d,https://pubmed.ncbi.nlm.nih.gov/42857300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,39564530,A series of blue phosphorescent iridium complexes with thermally activated delayed fluorescence and efficiency roll-off properties.,2024,10.1039/d4ra05828c,https://pubmed.ncbi.nlm.nih.gov/39564530/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,29765523,"Overexpressing TPTE2 (TPIP), a homolog of the human tumor suppressor gene PTEN, rescues the abnormal phenotype of the PTEN-/- mutant.",2018,10.18632/oncotarget.24941,https://pubmed.ncbi.nlm.nih.gov/29765523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,39697703,Dephosphorylation-related signature predicts the prognosis of papillary renal cell carcinoma.,2024,10.21037/tcr-24-669,https://pubmed.ncbi.nlm.nih.gov/39697703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,38200081,"Genome, HLA and polygenic risk score analyses for prevalent and persistent cervical human papillomavirus (HPV) infections.",2024,10.1038/s41431-023-01521-7,https://pubmed.ncbi.nlm.nih.gov/38200081/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,36986795,Effect of Inhalation Profile on Delivery of Treprostinil Palmitil Inhalation Powder.,2023,10.3390/pharmaceutics15030934,https://pubmed.ncbi.nlm.nih.gov/36986795/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,36070132,"Safety, Tolerability, and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder for Pulmonary Hypertension: A Phase 1, Randomized, Double-Blind, Single- and Multiple-Dose Study.",2022,10.1007/s12325-022-02296-x,https://pubmed.ncbi.nlm.nih.gov/36070132/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,37313713,"Synthesis and biological evaluation of ruthenium complexes bearing the 1,2,4-triazole group as potential membrane-targeting antibacterial agents towards Staphylococcus aureus.",2023,10.1039/d3dt00889d,https://pubmed.ncbi.nlm.nih.gov/37313713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,37523149,Near-Infrared Bodipy-Based Molecular Rotors for β-Amyloid Imaging In Vivo.,2023,10.1002/adhm.202300733,https://pubmed.ncbi.nlm.nih.gov/37523149/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,34089056,Exome sequencing reveals variants in known and novel candidate genes for severe sperm motility disorders.,2021,10.1093/humrep/deab099,https://pubmed.ncbi.nlm.nih.gov/34089056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,22164291,"A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells.",2011,10.1371/journal.pone.0028433,https://pubmed.ncbi.nlm.nih.gov/22164291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,37056996,A retrospective analysis of phosphatase catalytic subunit gene variants in patients with rare disorders identifies novel candidate neurodevelopmental disease genes.,2023,10.3389/fcell.2023.1107930,https://pubmed.ncbi.nlm.nih.gov/37056996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,29556364,Novel Self-assembled Organic Nanoprobe for Molecular Imaging and Treatment of Gram-positive Bacterial Infection.,2018,10.7150/thno.22534,https://pubmed.ncbi.nlm.nih.gov/29556364/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,34410590,Discovery of Genetic Biomarkers for Alzheimer's Disease Using Adaptive Convolutional Neural Networks Ensemble and Genome-Wide Association Studies.,2021,10.1007/s12539-021-00470-3,https://pubmed.ncbi.nlm.nih.gov/34410590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,26230935,"TODRA, a lncRNA at the RAD51 Locus, Is Oppositely Regulated to RAD51, and Enhances RAD51-Dependent DSB (Double Strand Break) Repair.",2015,10.1371/journal.pone.0134120,https://pubmed.ncbi.nlm.nih.gov/26230935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,33614774,Characterisation of cough evoked by inhaled treprostinil and treprostinil palmitil.,2021,10.1183/23120541.00592-2020,https://pubmed.ncbi.nlm.nih.gov/33614774/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,32636742,"Modulation of KV7 Channel Deactivation by PI(4,5)P2.",2020,10.3389/fphar.2020.00895,https://pubmed.ncbi.nlm.nih.gov/32636742/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,22896666,A human phospholipid phosphatase activated by a transmembrane control module.,2012,10.1194/jlr.m026021,https://pubmed.ncbi.nlm.nih.gov/22896666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,19464661,Thromboxane A2-induced signal transduction is negatively regulated by KIAA1005 that directly interacts with thromboxane A2 receptor.,2009,10.1016/j.prostaglandins.2009.02.001,https://pubmed.ncbi.nlm.nih.gov/19464661/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,21399728,Intra-organ Biodistribution of Gold Nanoparticles Using Intrinsic Two-photon Induced Photoluminescence.,2010,10.1002/lsm.20935,https://pubmed.ncbi.nlm.nih.gov/21399728/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,21105107,Genetic variations at loci involved in the immune response are risk factors for hepatocellular carcinoma.,2010,10.1002/hep.23943,https://pubmed.ncbi.nlm.nih.gov/21105107/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPTE2,ENSG00000132958,CTA,11716755,TPIP: a novel phosphoinositide 3-phosphatase.,2001,10.1042/0264-6021:3600277,https://pubmed.ncbi.nlm.nih.gov/11716755/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
TRIM42,ENSG00000155890,CTA,41583004,Exploring rare coding variants in UK biobank: preliminary associations with motor neuron disease.,2025,10.3389/fnagi.2025.1735522,https://pubmed.ncbi.nlm.nih.gov/41583004/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM42,ENSG00000155890,CTA,41518904,Genomic insights on the Parma and Piacenza Italian native turkey breed for conservation and traceability.,2026,10.1016/j.psj.2025.106279,https://pubmed.ncbi.nlm.nih.gov/41518904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM42,ENSG00000155890,CTA,23791107,"Dissecting disease inheritance modes in a three-dimensional protein network challenges the ""guilt-by-association"" principle.",2013,10.1016/j.ajhg.2013.05.022,https://pubmed.ncbi.nlm.nih.gov/23791107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML1,ENSG00000184108,CTA,40146919,Expression of tripartite motif family-like protein 1 and 2 in early conceptus development and placentation in the pig.,2025,10.1530/raf-24-0107,https://pubmed.ncbi.nlm.nih.gov/40146919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML1,ENSG00000184108,CTA,40572022,Mouse genome engineering uncovers 18 genes dispensable for male reproduction.,2026,10.1111/andr.70088,https://pubmed.ncbi.nlm.nih.gov/40572022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML1,ENSG00000184108,CTA,31633784,Eutherian-Specific Gene TRIML2 Attenuates Inflammation in the Evolution of Placentation.,2020,10.1093/molbev/msz238,https://pubmed.ncbi.nlm.nih.gov/31633784/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML1,ENSG00000184108,CTA,34794455,Prenatal diagnosis of a 4.5-Mb deletion at chromosome 4q35.1q35.2: Case report and literature review.,2021,10.1186/s13039-021-00573-y,https://pubmed.ncbi.nlm.nih.gov/34794455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML1,ENSG00000184108,CTA,19156909,Characterization and potential function of a novel pre-implantation embryo-specific RING finger protein: TRIML1.,2009,10.1002/mrd.20997,https://pubmed.ncbi.nlm.nih.gov/19156909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML1,ENSG00000184108,CTA,20187927,Microarray-based gene expression profiling and DNA copy number variation analysis of temporal fossa arachnoid cysts.,2010,10.1186/1743-8454-7-6,https://pubmed.ncbi.nlm.nih.gov/20187927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPC5OS,ENSG00000204025,CTA,35584604,TRPC5OS induces tumorigenesis by increasing ENO1-mediated glucose uptake in breast cancer.,2022,10.1016/j.tranon.2022.101447,https://pubmed.ncbi.nlm.nih.gov/35584604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPC5OS,ENSG00000204025,CTA,35765270,Comparative analysis of transient receptor potential channel 5 opposite strand-induced gene expression patterns and protein-protein interactions in triple-negative breast cancer.,2022,10.3892/ol.2022.13379,https://pubmed.ncbi.nlm.nih.gov/35765270/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,41075272,Genetic heterogeneity and homogeneity among orofacial cleft subtypes: genome-wide association studies in the cleft collective.,2025,10.1093/hmg/ddaf131,https://pubmed.ncbi.nlm.nih.gov/41075272/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,40356234,Genetics of Childhood-Onset Systemic Lupus Erythematosus.,2025,10.1002/art.43227,https://pubmed.ncbi.nlm.nih.gov/40356234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,39580850,GENETIC ASSOCIATIONS WITH ASTHMA IN THE KAZAKH POPULATION: A CASE-CONTROL STUDY FOCUSING ON ACTN3 AND TSBP1 POLYMORPHISMS.,2024,,https://pubmed.ncbi.nlm.nih.gov/39580850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,36814110,Celiac disease-associated loci show considerable genetic overlap with neuropsychiatric diseases but with limited transethnic applicability.,2023,10.1007/s12041-022-01413-7,https://pubmed.ncbi.nlm.nih.gov/36814110/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,37336276,"Evaluation of genetic risk, its clinical manifestation and disease management based on 18 susceptibility gene markers among West-Slavonic patients with sarcoidosis.",2023,10.1016/j.gene.2023.147577,https://pubmed.ncbi.nlm.nih.gov/37336276/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,40514052,Genetic relationships between systemic lupus erythematosus and a positive antinuclear antibody test in the absence of autoimmune disease.,2025,10.1136/lupus-2024-001476,https://pubmed.ncbi.nlm.nih.gov/40514052/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,40762897,Integrative GWAS and Mendelian randomization study of rheumatoid arthritis based on the 2019 UK Biobank questionnaire.,2025,10.1007/s10067-025-07590-x,https://pubmed.ncbi.nlm.nih.gov/40762897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,34325306,Genetic association and differential expression of HLAComplexGroup lncRNAs in pemphigus.,2021,10.1016/j.jaut.2021.102705,https://pubmed.ncbi.nlm.nih.gov/34325306/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,37560832,[Multiple sclerosis in the Republic of Bashkortostan: population-specific genetic predictors and the results of a 20-year clinical follow-up study].,2023,10.17116/jnevro202312307234,https://pubmed.ncbi.nlm.nih.gov/37560832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,38654358,Shared genetic factors and causal association between chronic hepatitis C infection and diffuse large B cell lymphoma.,2024,10.1186/s13027-024-00577-4,https://pubmed.ncbi.nlm.nih.gov/38654358/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,33022050,Shared Signature of Recent Positive Selection on the TSBP1-BTNL2-HLA-DRA Genes in Five Native Populations from North Borneo.,2020,10.1093/gbe/evaa207,https://pubmed.ncbi.nlm.nih.gov/33022050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,31297130,C6orf10 Low-Frequency and Rare Variants in Italian Multiple Sclerosis Patients.,2019,10.3389/fgene.2019.00573,https://pubmed.ncbi.nlm.nih.gov/31297130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,32990896,The exploration of Parkinson's disease: a multi-modal data analysis of resting functional magnetic resonance imaging and gene data.,2021,10.1007/s11682-020-00392-6,https://pubmed.ncbi.nlm.nih.gov/32990896/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,35500836,A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-Ethnic Validation in Asians.,2022,10.1016/j.jtho.2022.04.011,https://pubmed.ncbi.nlm.nih.gov/35500836/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,32921502,No association of CpG SNP rs9357140 with onset age in Belgian C9orf72 repeat expansion carriers.,2021,10.1016/j.neurobiolaging.2020.07.021,https://pubmed.ncbi.nlm.nih.gov/32921502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,35386192,Identification of Potential Pleiotropic Genes for Immune and Skeletal Diseases Using Multivariate MetaCCA Analysis.,2021,10.2174/1389202923666211223115214,https://pubmed.ncbi.nlm.nih.gov/35386192/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,30252044,A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers.,2018,10.1093/brain/awy238,https://pubmed.ncbi.nlm.nih.gov/30252044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,32723974,Identifying CpG methylation signature as a promising biomarker for recurrence and immunotherapy in non-small-cell lung carcinoma.,2020,10.18632/aging.103517,https://pubmed.ncbi.nlm.nih.gov/32723974/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,35751838,Imputation of the major histocompatibility complex region identifies major independent variants associated with bullous pemphigoid and dermatomyositis in Han Chinese.,2022,10.1111/1346-8138.16499,https://pubmed.ncbi.nlm.nih.gov/35751838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,32827573,Genome-wide identification of m6A-associated single-nucleotide polymorphisms in Parkinson's disease.,2020,10.1016/j.neulet.2020.135315,https://pubmed.ncbi.nlm.nih.gov/32827573/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,31119452,An update on genetic frontotemporal dementia.,2019,10.1007/s00415-019-09363-4,https://pubmed.ncbi.nlm.nih.gov/31119452/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,26253105,Knowledge-based analysis of genetic associations of rheumatoid arthritis to inform studies searching for pleiotropic genes: a literature review and network analysis.,2015,10.1186/s13075-015-0715-1,https://pubmed.ncbi.nlm.nih.gov/26253105/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,27508393,Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases.,2016,10.1371/journal.pone.0160573,https://pubmed.ncbi.nlm.nih.gov/27508393/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,27863461,Pooled genome wide association detects association upstream of FCRL3 with Graves' disease.,2016,10.1186/s12864-016-3276-z,https://pubmed.ncbi.nlm.nih.gov/27863461/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,22751097,Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.,2012,10.1038/ng.2337,https://pubmed.ncbi.nlm.nih.gov/22751097/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,22541561,A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.,2012,10.1016/j.ajhg.2012.04.001,https://pubmed.ncbi.nlm.nih.gov/22541561/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,19680446,Multiple Loci within the major histocompatibility complex confer risk of psoriasis.,2009,10.1371/journal.pgen.1000606,https://pubmed.ncbi.nlm.nih.gov/19680446/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,21326295,Genome-wide analysis identifies a quantitative trait locus in the MHC class II region associated with generalized vitiligo age of onset.,2011,10.1038/jid.2011.12,https://pubmed.ncbi.nlm.nih.gov/21326295/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSBP1,ENSG00000204296,CTA,20662065,Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus.,2010,10.1002/art.27658,https://pubmed.ncbi.nlm.nih.gov/20662065/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10IP,ENSG00000175513,CTA,37862216,Casein kinase-2 inhibition promotes retinal ganglion cell survival after acute intraocular pressure elevation.,2024,10.4103/1673-5374.385310,https://pubmed.ncbi.nlm.nih.gov/37862216/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,42363281,The TSPY gene and the loss of Y chromosome predisposition to cancers.,2026,10.1186/s13578-026-01614-y,https://pubmed.ncbi.nlm.nih.gov/42363281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,42899482,Tumour Antigen-Specific Antibody Signatures as Diagnostic Biomarkers for Melanoma.,2026,10.1002/ijc.70726,https://pubmed.ncbi.nlm.nih.gov/42899482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,41897314,"TSPY-like 2, Beyond the Histone Chaperone Role.",2026,10.3390/biom16030378,https://pubmed.ncbi.nlm.nih.gov/41897314/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,40563082,The human testis-specific protein Y-linked (TSPY) is a male-specific cancer-testis antigen capable of eliciting significant immune responses and elimination of positive tumor cells in hepatocellular carcinoma.,2025,10.1186/s13578-025-01432-8,https://pubmed.ncbi.nlm.nih.gov/40563082/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,41897406,Divergent Amplification of Y-Linked Dosage-Sensitive Genes Triggers Regulatory Mismatch Underlying Cattle-Yak Male Sterility.,2026,10.3390/biom16030471,https://pubmed.ncbi.nlm.nih.gov/41897406/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,38185096,Mouse Tspyl5 promotes spermatogonia proliferation through enhancing Pcna-mediated DNA replication.,2024,10.1071/rd23042,https://pubmed.ncbi.nlm.nih.gov/38185096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,42791104,Tumor risk in patients with differences in sex development (DSD) statements and recommendations from the first update of the German guideline for DSD.,2026,10.1016/j.jpurol.2026.106267,https://pubmed.ncbi.nlm.nih.gov/42791104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,40326206,"Elaborately Engineered Aggregation-Induced Emission Antibacterial Agents: Negligible Living Cell Invasiveness, Efficient Bacterial Biofilm Inhibition and Promoting Infected Wound Healing.",2025,10.1002/smll.202502762,https://pubmed.ncbi.nlm.nih.gov/40326206/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,42510778,Isolation and Sequencing of the Y Chromosome in Mediterranean River Buffalo Using Laser Microdissection-Based NGS.,2026,10.3390/genes17070740,https://pubmed.ncbi.nlm.nih.gov/42510778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,36261201,Testis-specific protein Y-encoded 1 regulates androgen receptor expression through the MAPK/ERK pathway in male hepatocellular carcinoma.,2022,10.15537/smj.2022.43.10.20220455,https://pubmed.ncbi.nlm.nih.gov/36261201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,40764380,Association between sex and the developmental morphokinetics of in vitro derived bovine embryos.,2025,10.1038/s41598-025-14017-9,https://pubmed.ncbi.nlm.nih.gov/40764380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,36834761,Testis-Specific Protein Y-Encoded (TSPY) Is Required for Male Early Embryo Development in Bos taurus.,2023,10.3390/ijms24043349,https://pubmed.ncbi.nlm.nih.gov/36834761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,40413144,Is it possible to separate the testicular and ovarian components of an ovotestis?,2025,10.1016/j.jpurol.2025.04.009,https://pubmed.ncbi.nlm.nih.gov/40413144/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,37967251,Transcript Isoform Diversity of Ampliconic Genes on the Y Chromosome of Great Apes.,2023,10.1093/gbe/evad205,https://pubmed.ncbi.nlm.nih.gov/37967251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,39432959,Two-pronged strategy: A mitochondria targeting AIE photosensitizer for hydrogen sulfide detection and type I and type II photodynamic therapy.,2025,10.1016/j.talanta.2024.127074,https://pubmed.ncbi.nlm.nih.gov/39432959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,38218629,Ovotesticular cords and ovotesticular follicles: New histologic markers for human ovotesticular syndrome.,2024,10.1016/j.jpurol.2023.12.016,https://pubmed.ncbi.nlm.nih.gov/38218629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,28847364,"Spermatogenic phenotype of testis-specific protein, Y-encoded, 1 (TSPY1) dosage deficiency is independent of variations in TSPY-like 1 (TSPYL1) and TSPY-like 5 (TSPYL5): a case-control study in a Han Chinese population.",2018,10.1071/rd17146,https://pubmed.ncbi.nlm.nih.gov/28847364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,42428162,"On the Phylogenetic History of the Sanje Mangabey (&lt;i&gt;Cercocebus sanjei&lt;/i&gt;), Udzungwa Mountains, Tanzania.",2026,10.1007/s10764-026-00559-w,https://pubmed.ncbi.nlm.nih.gov/42428162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,33185915,Epigenetic modification-dependent androgen receptor occupancy facilitates the ectopic TSPY1 expression in prostate cancer cells.,2021,10.1111/cas.14731,https://pubmed.ncbi.nlm.nih.gov/33185915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,29748603,TSPY1 suppresses USP7-mediated p53 function and promotes spermatogonial proliferation.,2018,10.1038/s41419-018-0589-7,https://pubmed.ncbi.nlm.nih.gov/29748603/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,30815935,"Testis-specific protein, Y-linked 1 activates PI3K/AKT and RAS signaling pathways through suppressing IGFBP3 expression during tumor progression.",2019,10.1111/cas.13984,https://pubmed.ncbi.nlm.nih.gov/30815935/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,36918555,Sex specific regulation of TSPY-Like 2 in the DNA damage response of cancer cells.,2023,10.1038/s41419-023-05722-2,https://pubmed.ncbi.nlm.nih.gov/36918555/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,37578081,"A novel model incorporating chromatin regulatory factors for risk stratification, prognosis prediction, and characterization of the microenvironment in Wilms tumor.",2024,10.1002/jgm.3574,https://pubmed.ncbi.nlm.nih.gov/37578081/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,31344101,A novel nested polymerase chain reaction targeting the testis-specific protein Y-encoded family of genes for high sensitivity of recent semen exposure detection: Comparison with four other assays of semen detection.,2019,10.1371/journal.pone.0220326,https://pubmed.ncbi.nlm.nih.gov/31344101/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,38382216,"Evaluation of blastocyst re-expansion, quality in relation to storage temperature, and sexing using blastocoel fluid after manual perforation with a hand-held needle involving in vivo produced equine embryos.",2024,10.1016/j.theriogenology.2024.02.012,https://pubmed.ncbi.nlm.nih.gov/38382216/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,24528896,Expression of a Y-located human proto-oncogene TSPY in a transgenic mouse model of prostate cancer.,2014,10.1186/2045-3701-4-9,https://pubmed.ncbi.nlm.nih.gov/24528896/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,24586606,Over-expressed Testis-specific Protein Y-encoded 1 as a novel biomarker for male hepatocellular carcinoma.,2014,10.1371/journal.pone.0089219,https://pubmed.ncbi.nlm.nih.gov/24586606/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,22688524,Testis-specific protein Y-encoded copy number is correlated to its expression and the field fertility of Canadian Holstein bulls.,2012,10.1159/000338938,https://pubmed.ncbi.nlm.nih.gov/22688524/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,16106251,TSPY is a cancer testis antigen expressed in human hepatocellular carcinoma.,2005,10.1038/sj.bjc.6602716,https://pubmed.ncbi.nlm.nih.gov/16106251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,31949263,"Identification, functional prediction, and key lncRNA verification of cold stress-related lncRNAs in rats liver.",2020,10.1038/s41598-020-57451-7,https://pubmed.ncbi.nlm.nih.gov/31949263/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,21949806,Molecular mining of alleles in water buffalo Bubalus bubalis and characterization of the TSPY1 and COL6A1 genes.,2011,10.1371/journal.pone.0024958,https://pubmed.ncbi.nlm.nih.gov/21949806/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,23724045,Fetal-maternal interactions in the synepitheliochorial placenta using the eGFP cloned cattle model.,2013,10.1371/journal.pone.0064399,https://pubmed.ncbi.nlm.nih.gov/23724045/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,20691057,Genetic integrity of the human Y chromosome exposed to groundwater arsenic.,2010,10.1186/1755-8794-3-35,https://pubmed.ncbi.nlm.nih.gov/20691057/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,10090875,"Gonadoblastoma, testicular and prostate cancers, and the TSPY gene.",1999,10.1086/302353,https://pubmed.ncbi.nlm.nih.gov/10090875/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,16207477,Survey of differentially methylated promoters in prostate cancer cell lines.,2005,10.1593/neo.05289,https://pubmed.ncbi.nlm.nih.gov/16207477/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,11840486,Detection of Y-specific sequences in 122 patients with Turner syndrome: nested PCR is not a reliable method.,2002,10.1002/ajmg.10168,https://pubmed.ncbi.nlm.nih.gov/11840486/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,10747295,Expression analysis of thirty one Y chromosome genes in human prostate cancer.,2000,10.1002/(sici)1098-2744(200004)27:4<308::aid-mc9>3.0.co;2-r,https://pubmed.ncbi.nlm.nih.gov/10747295/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY1,ENSG00000258992,CTA,8923009,"Testis-specific protein, Y-encoded (TSPY) expression in testicular tissues.",1996,10.1093/hmg/5.11.1801,https://pubmed.ncbi.nlm.nih.gov/8923009/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY2,ENSG00000168757,CTA,31103297,"Comparison of Y-chromosome-linked TSPY, TSPY2, and PRAMEY genes in Taurus cattle, yaks, and interspecific hybrid bulls.",2019,10.3168/jds.2018-15680,https://pubmed.ncbi.nlm.nih.gov/31103297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY2,ENSG00000168757,CTA,27103889,Non-negligible Occurrence of Errors in Gender Description in Public Data Sets.,2016,10.5808/gi.2016.14.1.34,https://pubmed.ncbi.nlm.nih.gov/27103889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY2,ENSG00000168757,CTA,10773691,Characterization of a new TSPY gene family member in Yq (TSPYq1).,2000,10.1159/000015510,https://pubmed.ncbi.nlm.nih.gov/10773691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY3,ENSG00000228927,CTA,42450814,Y-Linked Expression Signatures Distinguish Dysfunctional Testicular States in Sheep.,2026,10.3390/ani16132107,https://pubmed.ncbi.nlm.nih.gov/42450814/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY3,ENSG00000228927,CTA,30760267,Genomic evidence of Y chromosome microchimerism in the endometrium during endometriosis and in cases of infertility.,2019,10.1186/s12958-019-0465-z,https://pubmed.ncbi.nlm.nih.gov/30760267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY4,ENSG00000233803,CTA,36446526,Transcriptome analyses in infertile men reveal germ cell-specific expression and splicing patterns.,2023,10.26508/lsa.202201633,https://pubmed.ncbi.nlm.nih.gov/36446526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY4,ENSG00000233803,CTA,39297564,Comprehensive Analysis of Juvenile Nasopharyngeal Angiofibromas via Whole-Exome Sequencing.,2024,10.1002/gcc.23265,https://pubmed.ncbi.nlm.nih.gov/39297564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY4,ENSG00000233803,CTA,31171972,Genes located in Y-chromosomal regions important for male fertility show altered transcript levels in cryptorchidism and respond to curative hormone treatment.,2019,10.1186/s12610-019-0089-3,https://pubmed.ncbi.nlm.nih.gov/31171972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY4,ENSG00000233803,CTA,33955178,A prospective clinical trial evaluating changes in the wound microenvironment in patients with chronic venous leg ulcers treated with a hypothermically stored amniotic membrane.,2022,10.1111/iwj.13606,https://pubmed.ncbi.nlm.nih.gov/33955178/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY4,ENSG00000233803,CTA,27259675,Assessment of the vaginal residence time of biomarkers of semen exposure.,2016,10.1016/j.contraception.2016.05.012,https://pubmed.ncbi.nlm.nih.gov/27259675/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY4,ENSG00000233803,CTA,23312930,TSPY4 is a novel sperm-specific biomarker of semen exposure in human cervicovaginal fluids; potential use in HIV prevention and contraception studies.,2013,10.1016/j.contraception.2012.11.022,https://pubmed.ncbi.nlm.nih.gov/23312930/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPY4,ENSG00000233803,CTA,25489736,"Development of a composite measure of product adherence, protocol compliance, and semen exposure using DNA and protein biomarkers for topical HIV prevention studies.",2014,10.1371/journal.pone.0114368,https://pubmed.ncbi.nlm.nih.gov/25489736/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPYL6,ENSG00000178021,CTA,36518674,Testis- specific Y-encoded- like protein 1 and cholesterol metabolism: Regulation of CYP1B1 expression through Wnt signaling.,2022,10.3389/fphar.2022.1047318,https://pubmed.ncbi.nlm.nih.gov/36518674/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPYL6,ENSG00000178021,CTA,27458158,Association between single nucleotide polymorphisms in the TSPYL6 gene and breast cancer susceptibility in the Han Chinese population.,2016,10.18632/oncotarget.10754,https://pubmed.ncbi.nlm.nih.gov/27458158/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPYL6,ENSG00000178021,CTA,29027195,TSPYL Family Regulates CYP17A1 and CYP3A4 Expression: Potential Mechanism Contributing to Abiraterone Response in Metastatic Castration-Resistant Prostate Cancer.,2018,10.1002/cpt.907,https://pubmed.ncbi.nlm.nih.gov/29027195/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPYL6,ENSG00000178021,CTA,33034841,Comprehensive analysis of the immunological landscape of pituitary adenomas: implications of immunotherapy for pituitary adenomas.,2020,10.1007/s11060-020-03636-z,https://pubmed.ncbi.nlm.nih.gov/33034841/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPYL6,ENSG00000178021,CTA,27686078,Association of ACYP2 and TSPYL6 Genetic Polymorphisms with Risk of Ischemic Stroke in Han Chinese Population.,2017,10.1007/s12035-016-0086-x,https://pubmed.ncbi.nlm.nih.gov/27686078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPYL6,ENSG00000178021,CTA,24939957,Identification of a duplication within the GDF9 gene and novel candidate genes for primary ovarian insufficiency (POI) by a customized high-resolution array comparative genomic hybridization platform.,2014,10.1093/humrep/deu149,https://pubmed.ncbi.nlm.nih.gov/24939957/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,42228803,Development of TSSK1 and TSSK2 Targeted Degraders Reveals Sperm Machinery for Protein Degradation and Potential for Nonhormonal Male Contraception.,2026,10.1021/acs.jmedchem.5c03689,https://pubmed.ncbi.nlm.nih.gov/42228803/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,42188159,RNA Interference Targeting Testis-Specific Serine/Threonine Protein Kinase 1 (&lt;i&gt;TSSK1&lt;/i&gt;) Gene Triggers Male Infertility in &lt;i&gt;Zeugodacus tau&lt;/i&gt;.,2026,10.3390/insects17050492,https://pubmed.ncbi.nlm.nih.gov/42188159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,40305308,Identification of TSSK1 and TSSK2 as Novel Targets for Male Contraception.,2025,10.3390/biom15040601,https://pubmed.ncbi.nlm.nih.gov/40305308/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,41972556,The Molecular Characterization and Functional Analysis of &lt;i&gt;Pomacea canaliculata&lt;/i&gt; Boule: A Central Player in Spermatogenesis and Male Fertility.,2026,10.3390/biology15070554,https://pubmed.ncbi.nlm.nih.gov/41972556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,40849036,Molecular expression of genes related to sex differentiation and their response to sex steroid hormones in the clam Chinese cyclina (Cyclina sinensis).,2025,10.1016/j.cbpb.2025.111148,https://pubmed.ncbi.nlm.nih.gov/40849036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,36670860,The Biological Characteristics and Differential Expression Patterns of TSSK1B Gene in Yak and Its Infertile Hybrid Offspring.,2023,10.3390/ani13020320,https://pubmed.ncbi.nlm.nih.gov/36670860/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,38245531,The LKB1-TSSK1B axis controls YAP phosphorylation to regulate the Hippo-YAP pathway.,2024,10.1038/s41419-024-06465-4,https://pubmed.ncbi.nlm.nih.gov/38245531/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,37550055,Expression of Testis-specific Serine/Threonine Kinases during the Reproductive and Nonreproductive Seasons and Their Localization in Mature Spermatozoa of Tree Shrews (Tupaia belangeri).,2023,10.30802/aalas-cm-23-000043,https://pubmed.ncbi.nlm.nih.gov/37550055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,35485285,Role of testis‑specific serine kinase 1B in undiagnosed male infertility.,2022,10.3892/mmr.2022.12720,https://pubmed.ncbi.nlm.nih.gov/35485285/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,38847481,Male infertility and perfluoroalkyl and poly-fluoroalkyl substances: evidence for alterations in phosphorylation of proteins and fertility-related functional attributes in bull spermatozoa†.,2024,10.1093/biolre/ioae089,https://pubmed.ncbi.nlm.nih.gov/38847481/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,39331630,Whole-genome Sequencing Association Analysis of Quantitative Platelet Traits in A Large Cohort of β-thalassemia.,2025,10.1093/gpbjnl/qzae065,https://pubmed.ncbi.nlm.nih.gov/39331630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,37929852,"Insights on reproduction-related genes in the striped fruit fly, Zeugodacus scutellata (Hendel) (Diptera: Tephritidae).",2024,10.1002/arch.22064,https://pubmed.ncbi.nlm.nih.gov/37929852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,36906820,QSAR via multisite λ-dynamics in the orphaned TSSK1B kinase.,2023,10.1002/pro.4623,https://pubmed.ncbi.nlm.nih.gov/36906820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,40832614,"Statins regulate kinase signaling by causing changes in phosphorylation, rather than through changes in gene expression or direct inhibition: evidence in colorectal cancer.",2025,10.3389/fphar.2025.1653702,https://pubmed.ncbi.nlm.nih.gov/40832614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,31825975,Characterization of testis-specific serine/threonine kinase 1-like (TSSK1-like) gene and expression patterns in diploid and triploid Pacific abalone (Haliotis discus hannai; Gastropoda; Mollusca) males.,2019,10.1371/journal.pone.0226022,https://pubmed.ncbi.nlm.nih.gov/31825975/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,35173218,Using publicly available transcriptomic data to identify mechanistic and diagnostic biomarkers in azoospermia and overall male infertility.,2022,10.1038/s41598-022-06476-1,https://pubmed.ncbi.nlm.nih.gov/35173218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,37151112,Integrated testis transcriptome and whole genome analysis of sexual maturity in Large White and Tongcheng pigs.,2023,10.1111/rda.14373,https://pubmed.ncbi.nlm.nih.gov/37151112/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,33765466,"cDNA cloning, expression and bioinformatical analysis of Tssk genes in tree shrews.",2021,10.1016/j.compbiolchem.2021.107474,https://pubmed.ncbi.nlm.nih.gov/33765466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,32337545,Testis-specific serine kinase protein family in male fertility and as targets for non-hormonal male contraception†.,2020,10.1093/biolre/ioaa064,https://pubmed.ncbi.nlm.nih.gov/32337545/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,31185651,RNAi-Mediated Knockdown of Tssk1 and Tektin1 Genes Impair Male Fertility in Bactrocera dorsalis.,2019,10.3390/insects10060164,https://pubmed.ncbi.nlm.nih.gov/31185651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,23599433,"Heat shock protein 90 functions to stabilize and activate the testis-specific serine/threonine kinases, a family of kinases essential for male fertility.",2013,10.1074/jbc.m112.400978,https://pubmed.ncbi.nlm.nih.gov/23599433/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,20729278,Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis.,2011,10.1093/molehr/gaq071,https://pubmed.ncbi.nlm.nih.gov/20729278/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK1B,ENSG00000212122,CTA,15044604,Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm.,2004,10.1093/molehr/gah052,https://pubmed.ncbi.nlm.nih.gov/15044604/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC23L,ENSG00000205838,CTA,40595242,Meta-analysis of urinary metabolite GWAS studies identifies novel genome-wide significant loci.,2025,10.1038/s41598-025-07518-0,https://pubmed.ncbi.nlm.nih.gov/40595242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC23L,ENSG00000205838,CTA,34256696,Selection for environmental variance of litter size in rabbits involves genes in pathways controlling animal resilience.,2021,10.1186/s12711-021-00653-y,https://pubmed.ncbi.nlm.nih.gov/34256696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL13,ENSG00000213471,CTA,41399674,"Baseline expression levels of &lt;i&gt;WNT8B&lt;/i&gt;, &lt;i&gt;KRT2&lt;/i&gt;, and &lt;i&gt;TTLL13P&lt;/i&gt; are associated with abrocitinib response in atopic dermatitis.",2026,10.1016/j.jdin.2025.10.007,https://pubmed.ncbi.nlm.nih.gov/41399674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL13,ENSG00000213471,CTA,40593606,CFAP100 couples microtubule glutamylation to spindle pole integrity in keratinocytes to promote epidermal development.,2025,10.1038/s41467-025-60677-6,https://pubmed.ncbi.nlm.nih.gov/40593606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL13,ENSG00000213471,CTA,37427890,CircTTLL13 Promotes TMZ Resistance in Glioma via Modulating OLR1-Mediated Activation of the Wnt/β-Catenin Pathway.,2023,10.1080/10985549.2023.2210032,https://pubmed.ncbi.nlm.nih.gov/37427890/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL13,ENSG00000213471,CTA,28794449,IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development.,2017,10.1038/s41467-017-00235-x,https://pubmed.ncbi.nlm.nih.gov/28794449/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC8,ENSG00000204193,CTA,32851881,"Sperm content of TXNDC8 reflects sperm chromatin structure, pregnancy establishment, and incidence of multiple births after ART.",2020,10.1080/19396368.2020.1801889,https://pubmed.ncbi.nlm.nih.gov/32851881/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC8,ENSG00000204193,CTA,25999356,Negative biomarker based male fertility evaluation: Sperm phenotypes associated with molecular-level anomalies.,2015,10.4103/1008-682x.153847,https://pubmed.ncbi.nlm.nih.gov/25999356/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC8,ENSG00000204193,CTA,33233438,Regulatory Potential of Long Non-Coding RNAs (lncRNAs) in Boar Spermatozoa with Good and Poor Freezability.,2020,10.3390/life10110300,https://pubmed.ncbi.nlm.nih.gov/33233438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC8,ENSG00000204193,CTA,23734172,Semen levels of spermatid-specific thioredoxin-3 correlate with pregnancy rates in ART couples.,2013,10.1371/journal.pone.0061000,https://pubmed.ncbi.nlm.nih.gov/23734172/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC8,ENSG00000204193,CTA,24728569,Molecular analysis of testis biopsy and semen pellet as complementary methods with histopathological analysis of testis in non-obstructive azoospermia.,2014,10.1007/s10815-014-0220-5,https://pubmed.ncbi.nlm.nih.gov/24728569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC8,ENSG00000204193,CTA,31028280,Pathway analysis of a genome-wide gene by air pollution interaction study in asthmatic children.,2019,10.1038/s41370-019-0136-3,https://pubmed.ncbi.nlm.nih.gov/31028280/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC8,ENSG00000204193,CTA,25636736,Subcellular localization of six thioredoxins and their antioxidant activity and contributions to biological control potential in Beauveria bassiana.,2015,10.1016/j.fgb.2015.01.008,https://pubmed.ncbi.nlm.nih.gov/25636736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC8,ENSG00000204193,CTA,15181017,"Spermatocyte/spermatid-specific thioredoxin-3, a novel Golgi apparatus-associated thioredoxin, is a specific marker of aberrant spermatogenesis.",2004,10.1074/jbc.m404192200,https://pubmed.ncbi.nlm.nih.gov/15181017/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2U,ENSG00000177414,CTA,39377024,Identification of key ubiquitination-related genes in gestational diabetes mellitus: A bioinformatics-driven study.,2024,10.1002/hsr2.70115,https://pubmed.ncbi.nlm.nih.gov/39377024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2U,ENSG00000177414,CTA,33776059,Whole exome sequencing reveals putatively novel associations in retinopathies and drusen formation.,2021,10.1038/s41431-021-00872-3,https://pubmed.ncbi.nlm.nih.gov/33776059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2U,ENSG00000177414,CTA,32891597,"Development of DNA methylation markers for sperm, saliva and blood identification using pyrosequencing and qPCR/HRM.",2020,10.1016/j.ab.2020.113933,https://pubmed.ncbi.nlm.nih.gov/32891597/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2U,ENSG00000177414,CTA,27903633,"An E2-guided E3 Screen Identifies the RNF17-UBE2U Pair as Regulator of the Radiosensitivity, Immunodeficiency, Dysmorphic Features, and Learning Difficulties (RIDDLE) Syndrome Protein RNF168.",2017,10.1074/jbc.m116.758854,https://pubmed.ncbi.nlm.nih.gov/27903633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLN3,ENSG00000175520,CTA,42343390,"Identification of a 10-protein plasma signature for preclinical gout risk beyond serum urate: a robustness-first proteomic study in 33,147 normouricaemic individuals.",2026,10.1186/s12967-026-08505-3,https://pubmed.ncbi.nlm.nih.gov/42343390/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLN3,ENSG00000175520,CTA,37891374,Identification of hub genes associated with spermatogenesis by bioinformatics analysis.,2023,10.1038/s41598-023-45620-3,https://pubmed.ncbi.nlm.nih.gov/37891374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLN3,ENSG00000175520,CTA,40295064,Ubiquitin-proteasome Pathway-linked Gene Signatures as Prognostic Indicators in Prostate Cancer.,2025,10.21873/anticanres.17562,https://pubmed.ncbi.nlm.nih.gov/40295064/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLN3,ENSG00000175520,CTA,33784796,MicroRNA-targeting in spermatogenesis: Over-expressions of microRNA-23a/b-3p and its affected targeting of the genes ODF2 and UBQLN3 in spermatozoa of patients with oligoasthenozoospermia.,2021,10.1111/andr.13004,https://pubmed.ncbi.nlm.nih.gov/33784796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLN3,ENSG00000175520,CTA,33791879,"Impact of platelet-rich plasma versus selenium in ameliorating induced toxicity in rat testis: histological, immunohistochemical, and molecular study.",2021,10.1007/s00441-021-03439-2,https://pubmed.ncbi.nlm.nih.gov/33791879/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLN3,ENSG00000175520,CTA,37444499,UBQLN Family Members Regulate MYC in Lung Adenocarcinoma Cells.,2023,10.3390/cancers15133389,https://pubmed.ncbi.nlm.nih.gov/37444499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLN3,ENSG00000175520,CTA,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLN3,ENSG00000175520,CTA,25776854,"Ubqln3, a testis-specific gene, is dispensable for embryonic development and spermatogenesis in mice.",2015,10.1002/mrd.22475,https://pubmed.ncbi.nlm.nih.gov/25776854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLN3,ENSG00000175520,CTA,34836490,HYPK coordinates degradation of polyneddylated proteins by autophagy.,2022,10.1080/15548627.2021.1997053,https://pubmed.ncbi.nlm.nih.gov/34836490/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLN3,ENSG00000175520,CTA,24674348,The ubiquilin gene family: evolutionary patterns and functional insights.,2014,10.1186/1471-2148-14-63,https://pubmed.ncbi.nlm.nih.gov/24674348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLN3,ENSG00000175520,CTA,34337005,A Genome-Wide Association Study of Age-Related Hearing Impairment in Middle- and Old-Aged Chinese Twins.,2021,10.1155/2021/3629624,https://pubmed.ncbi.nlm.nih.gov/34337005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLN3,ENSG00000175520,CTA,22941507,Identification of the cancer/testis antigens AKAP3 and CTp11 by SEREX             in hepatocellular carcinoma.,2012,10.3892/or.2012.2002,https://pubmed.ncbi.nlm.nih.gov/22941507/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLN3,ENSG00000175520,CTA,24012201,Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis.,2013,10.1016/j.fertnstert.2013.07.1999,https://pubmed.ncbi.nlm.nih.gov/24012201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLN3,ENSG00000175520,CTA,10831842,"Molecular cloning, chromosome mapping and characterization of UBQLN3 a testis-specific gene that contains an ubiquitin-like domain.",2000,10.1016/s0378-1119(00)00122-0,https://pubmed.ncbi.nlm.nih.gov/10831842/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,42876898,Rapid and Sensitive Detection of &lt;i&gt;USP26&lt;/i&gt; Cluster Variants Based on CRISPR/Cas12a.,2026,10.1155/humu/5152235,https://pubmed.ncbi.nlm.nih.gov/42876898/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,41957346,Ubiquitin-specific protease 26 facilitates endochondral ossification by driving chondrocyte hypertrophy and mineralization.,2026,10.1038/s41413-026-00517-5,https://pubmed.ncbi.nlm.nih.gov/41957346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,42827478,USP26-mediated stabilization of RAD51 promotes endometrial cancer progression and limits ferroptosis.,2026,10.3389/fonc.2026.1896160,https://pubmed.ncbi.nlm.nih.gov/42827478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,42704679,USP26 Promotes Autophagosome-Lysosome Fusion to Improve Mitochondrial Function in the Repair of Gut Barrier Damage by Stabilizing STX17.,2026,10.1177/15230864261484565,https://pubmed.ncbi.nlm.nih.gov/42704679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,41423141,A novel candidate missense variant in the catalytic domain of USP26 associated with asthenoteratozoospermia.,2026,10.1016/j.gene.2025.149945,https://pubmed.ncbi.nlm.nih.gov/41423141/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,41417635,Activating the Osteoblastic USP26 Pathway Alleviates Multi-Organ Fibrosis by Decreasing Insulin Resistance.,2026,10.1002/advs.202512424,https://pubmed.ncbi.nlm.nih.gov/41417635/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,41687771,Osteoblastic USP26 regulates B lymphopoiesis by endogenous tryptophan metabolites.,2026,10.1016/j.jare.2026.02.010,https://pubmed.ncbi.nlm.nih.gov/41687771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,39251623,USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling.,2024,10.1038/s41467-024-52201-z,https://pubmed.ncbi.nlm.nih.gov/39251623/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,39932629,Genetic insights into non-obstructive azoospermia: Implications for diagnosis and TESE outcomes.,2025,10.1007/s10815-025-03409-5,https://pubmed.ncbi.nlm.nih.gov/39932629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,39377219,USP26 Combats Age-Related Declines in Self-Renewal and Multipotent Differentiation of BMSC by Maintaining Mitochondrial Homeostasis.,2024,10.1002/advs.202406428,https://pubmed.ncbi.nlm.nih.gov/39377219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,39058724,USP26 suppresses type I interferon signaling by targeting TRAF3 for deubiquitination.,2024,10.1371/journal.pone.0307776,https://pubmed.ncbi.nlm.nih.gov/39058724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,38880224,Acetylation-dependent deubiquitinase USP26 stabilizes BAG3 to promote breast cancer progression.,2024,10.1016/j.canlet.2024.217005,https://pubmed.ncbi.nlm.nih.gov/38880224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,38143276,Targeted Protein Fate Modulating Functional Microunits Promotes Intervertebral Fusion.,2024,10.1002/smtd.202301375,https://pubmed.ncbi.nlm.nih.gov/38143276/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,39155412,Targeting Osteoblast-Osteoclast Cross-Talk Bone Homeostasis Repair Microcarriers Promotes Intervertebral Fusion in Osteoporotic Rats.,2024,10.1002/adhm.202402117,https://pubmed.ncbi.nlm.nih.gov/39155412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,38565942,USP26 promotes colorectal cancer tumorigenesis by restraining PRKN-mediated mitophagy.,2024,10.1038/s41388-024-03009-0,https://pubmed.ncbi.nlm.nih.gov/38565942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,38064851,Machine learning-based classification of deubiquitinase USP26 and its cell proliferation inhibition through stabilizing KLF6 in cervical cancer.,2024,10.1016/j.compbiomed.2023.107745,https://pubmed.ncbi.nlm.nih.gov/38064851/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,35074940,The association between mutations in ubiquitin-specific protease 26 (USP26) and male infertility: a systematic review and meta-analysis.,2022,10.4103/aja2021109,https://pubmed.ncbi.nlm.nih.gov/35074940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,34202084,"Novel Mutations in X-Linked, USP26-Induced Asthenoteratozoospermia and Male Infertility.",2021,10.3390/cells10071594,https://pubmed.ncbi.nlm.nih.gov/34202084/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,35397626,USP26 promotes anaplastic thyroid cancer progression by stabilizing TAZ.,2022,10.1038/s41419-022-04781-1,https://pubmed.ncbi.nlm.nih.gov/35397626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,41838919,Active maintenance of meiosis-specific chromosome structures in &lt;i&gt;Caenorhabditis elegans&lt;/i&gt; by the deubiquitinase DUO-1.,2026,10.1073/pnas.2532671123,https://pubmed.ncbi.nlm.nih.gov/41838919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,35091692,The osteoprotective role of USP26 in coordinating bone formation and resorption.,2022,10.1038/s41418-021-00904-x,https://pubmed.ncbi.nlm.nih.gov/35091692/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,38511217,Systematic molecular analyses for 115 karyotypically normal men with isolated non-obstructive azoospermia.,2024,10.1093/humrep/deae057,https://pubmed.ncbi.nlm.nih.gov/38511217/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP26,ENSG00000134588,CTA,32636717,The plasma peptides of sepsis.,2020,10.1186/s12014-020-09288-5,https://pubmed.ncbi.nlm.nih.gov/32636717/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,42728695,Pervasive Positive Selection on X-linked Ampliconic Genes in Primates.,2026,10.1093/gbe/evag229,https://pubmed.ncbi.nlm.nih.gov/42728695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,41847879,Vascularized composite xenotransplantation: Where we have been and where we could go?,2026,10.1177/09636897261431041,https://pubmed.ncbi.nlm.nih.gov/41847879/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,42270600,"Radiation induces senescence in lymphatic endothelial cells (LECs) and murine tail lymphedema tissue, contributing to lymphedema progression.",2026,10.1038/s41419-026-08955-z,https://pubmed.ncbi.nlm.nih.gov/42270600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,40688208,"Cardiac arrhythmia, developmental delay, epilepsy and ichthyosis due to Xp22.31 deletion: review of literature and case report.",2025,10.21037/tp-2025-87,https://pubmed.ncbi.nlm.nih.gov/40688208/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,42574231,"The Vacuolar Ca&lt;sup&gt;2+&lt;/sup&gt;/H&lt;sup&gt;+&lt;/sup&gt; Exchanger AaVCX Regulates Calcium Homeostasis, the Differentiation of Infection Structures and Pathogenicity in Alternaria alternata Under the Transcriptional Control of AaCrz1.",2026,10.1111/mpp.70324,https://pubmed.ncbi.nlm.nih.gov/42574231/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,40411691,Controlled expansion stent grafts versus legacy stent grafts for transjugular intrahepatic portosystemic shunt: a single-centre retrospective study on the incidence of hepatic encephalopathy.,2025,10.1186/s42155-025-00557-8,https://pubmed.ncbi.nlm.nih.gov/40411691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,41055044,Calcium transport systems as virulence determinants: Mechanistic insights into fungal pathogenicity and antifungal resistance.,2025,10.1080/21505594.2025.2569624,https://pubmed.ncbi.nlm.nih.gov/41055044/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,37849634,Endotype Characterization Reveals Mechanistic Differences Across Brain Regions in Sporadic Alzheimer's Disease.,2023,10.3233/adr-220098,https://pubmed.ncbi.nlm.nih.gov/37849634/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,41351370,Shared gene functions in autoimmune diseases identified via integrated bioinformatics analysis.,2025,10.14715/cmb/2025.71.11.7,https://pubmed.ncbi.nlm.nih.gov/41351370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,41754828,A Machine Learning-Enabled Venom Peptide Platform for Rapid Drug Discovery.,2026,10.3390/ph19020288,https://pubmed.ncbi.nlm.nih.gov/41754828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,33634013,The Cancer/Testis Antigen Gene VCX2 Is Rarely Expressed in Malignancies but Can Be Epigenetically Activated Using DNA Methyltransferase and Histone Deacetylase Inhibitors.,2020,10.3389/fonc.2020.584024,https://pubmed.ncbi.nlm.nih.gov/33634013/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,40395294,Venetoclax inhibits autophagy in chronic lymphocytic leukemia cells.,2023,10.1080/27694127.2023.2169518,https://pubmed.ncbi.nlm.nih.gov/40395294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,34576177,NGF Eye Administration Recovers the TrkB and Glutamate/GABA Marker Deficit in the Adult Visual Cortex Following Optic Nerve Crush.,2021,10.3390/ijms221810014,https://pubmed.ncbi.nlm.nih.gov/34576177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,42727293,"Effect of high-power probe ultrasonication (20 kHz) treatment duration on the physicochemical, bioactive, mineral and microbiological quality of cranberry (Vaccinium macrocarpon) juice.",2026,10.1016/j.ultsonch.2026.108048,https://pubmed.ncbi.nlm.nih.gov/42727293/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,34380036,Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation.,2021,10.1016/j.celrep.2021.109508,https://pubmed.ncbi.nlm.nih.gov/34380036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,37347056,Case report: Sex-specific characteristics of epilepsy phenotypes associated with Xp22.31 deletion: a case report and review.,2023,10.3389/fgene.2023.1025390,https://pubmed.ncbi.nlm.nih.gov/37347056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,37684669,Copy number variations (CNVs) and karyotyping analysis in males with azoospermia and oligospermia.,2023,10.1186/s12920-023-01652-2,https://pubmed.ncbi.nlm.nih.gov/37684669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,31161555,DNA Methylation and SNPs in VCX are Correlated with Sex Differences in the Response to Chronic Hepatitis B.,2019,10.1007/s12250-019-00117-0,https://pubmed.ncbi.nlm.nih.gov/31161555/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,40157041,"Mosaic STS gene deletions in chorionic villus samples are often confined to the placenta, and they differ in size from STS gene deletions in patients with X-linked Ichthyosis.",2025,10.1016/j.placenta.2025.03.016,https://pubmed.ncbi.nlm.nih.gov/40157041/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,37298247,"MoCbp7, a Novel Calcineurin B Subunit-Binding Protein, Is Involved in the Calcium Signaling Pathway and Regulates Fungal Development, Virulence, and ER Homeostasis in Magnaporthe oryzae.",2023,10.3390/ijms24119297,https://pubmed.ncbi.nlm.nih.gov/37298247/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,42377541,Fluoroscopic quantification of early in vivo expansion of VIATORR controlled expansion stent-grafts after TIPS: hemodynamic and clinical implications.,2026,10.1007/s00261-026-05663-2,https://pubmed.ncbi.nlm.nih.gov/42377541/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,41874201,Effectiveness of chlorhexidine and xylitol varnish versus silver diamine fluoride in the control of initial dental caries lesions: a randomised clinical trial.,2026,10.23804/ejpd.2026.2361,https://pubmed.ncbi.nlm.nih.gov/41874201/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,36307019,Crosstalk between aryl hydrocarbon receptor (AhR) and BCL-2 pathways suggests the use of AhR antagonist to maintain normal differentiation state of mammary epithelial cells during BCL-2 inhibition therapy.,2023,10.1016/j.jare.2022.10.006,https://pubmed.ncbi.nlm.nih.gov/36307019/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,34013182,Controlled underdilation using novel VIATORR® controlled expansion stents improves survival after transjugular intrahepatic portosystemic shunt implantation.,2021,10.1016/j.jhepr.2021.100264,https://pubmed.ncbi.nlm.nih.gov/34013182/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,36519157,Investigation the global effect of rare earth gadolinium on the budding Saccharomyces cerevisiae by genome-scale screening.,2022,10.3389/fmicb.2022.1022054,https://pubmed.ncbi.nlm.nih.gov/36519157/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,37316081,Microcapsules of Sacha Inchi seed oil (Plukenetia volubilis L.) obtained by spray drying as a potential ingredient to formulate functional foods.,2023,10.1016/j.foodres.2023.113014,https://pubmed.ncbi.nlm.nih.gov/37316081/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,24970476,"A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets.",2014,10.1158/0008-5472.can-13-3725,https://pubmed.ncbi.nlm.nih.gov/24970476/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,33916082,Interactive Effects of Biosynthesized Nanocomposites and Their Antimicrobial and Cytotoxic Potentials.,2021,10.3390/nano11040903,https://pubmed.ncbi.nlm.nih.gov/33916082/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,37178307,"Adaptive responses of yeast strains tolerant to acidic pH, acetate, and supraoptimal temperature.",2023,10.1007/s00253-023-12556-7,https://pubmed.ncbi.nlm.nih.gov/37178307/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,32457789,Decreased Vacuolar Ca2+ Storage and Disrupted Vesicle Trafficking Underlie Alpha-Synuclein-Induced Ca2+ Dysregulation in S. cerevisiae.,2020,10.3389/fgene.2020.00266,https://pubmed.ncbi.nlm.nih.gov/32457789/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,30429015,Detection of autoantibodies against cancer-testis antigens in non-small cell lung cancer.,2018,10.1016/j.lungcan.2018.09.012,https://pubmed.ncbi.nlm.nih.gov/30429015/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,27699219,Profiling cancer testis antigens in non-small-cell lung cancer.,2016,10.1172/jci.insight.86837,https://pubmed.ncbi.nlm.nih.gov/27699219/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX,ENSG00000182583,CTA,20889719,The vacuolar Ca²(+) exchanger Vcx1 is involved in calcineurin-dependent Ca²(+) tolerance and virulence in Cryptococcus neoformans.,2010,10.1128/ec.00114-10,https://pubmed.ncbi.nlm.nih.gov/20889719/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX3A,ENSG00000169059,CTA,41091706,"A survey of human cancer-germline genes: Linking X chromosome localization, DNA methylation and sex-biased expression in early embryos.",2025,10.1371/journal.pgen.1011734,https://pubmed.ncbi.nlm.nih.gov/41091706/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX3A,ENSG00000169059,CTA,37347056,Case report: Sex-specific characteristics of epilepsy phenotypes associated with Xp22.31 deletion: a case report and review.,2023,10.3389/fgene.2023.1025390,https://pubmed.ncbi.nlm.nih.gov/37347056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX3A,ENSG00000169059,CTA,36017582,Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia.,2022,10.1111/andr.13269,https://pubmed.ncbi.nlm.nih.gov/36017582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX3A,ENSG00000169059,CTA,29453317,Histone H3.3K27M Mobilizes Multiple Cancer/Testis (CT) Antigens in Pediatric Glioma.,2018,10.1158/1541-7786.mcr-17-0460,https://pubmed.ncbi.nlm.nih.gov/29453317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX3A,ENSG00000169059,CTA,40636406,Single-cell transcriptome analysis reveals a cancer-associated fibroblast marker gene signature in hepatocellular carcinoma that predicts prognosis.,2023,10.1016/j.iliver.2022.12.002,https://pubmed.ncbi.nlm.nih.gov/40636406/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX3A,ENSG00000169059,CTA,24970476,"A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets.",2014,10.1158/0008-5472.can-13-3725,https://pubmed.ncbi.nlm.nih.gov/24970476/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX3A,ENSG00000169059,CTA,24715854,Decreased expression of genes associated with memory and x-linked mental retardation in boys with non-syndromic cryptorchidism and high infertility risk.,2014,10.1159/000357931,https://pubmed.ncbi.nlm.nih.gov/24715854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX3A,ENSG00000169059,CTA,28122887,Expanding the genetic spectrum of ANOS1 mutations in patients with congenital hypogonadotropic hypogonadism.,2017,10.1093/humrep/dew354,https://pubmed.ncbi.nlm.nih.gov/28122887/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX3A,ENSG00000169059,CTA,19252123,Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis.,2009,10.1128/ec.00336-08,https://pubmed.ncbi.nlm.nih.gov/19252123/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX3A,ENSG00000169059,CTA,18076704,"Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis.",2008,10.1111/j.1365-2133.2007.08373.x,https://pubmed.ncbi.nlm.nih.gov/18076704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX3A,ENSG00000169059,CTA,25626364,Negative regulation of the vacuole-mediated resistance to K(+) stress by a novel C2H2 zinc finger transcription factor encoded by aslA in Aspergillus nidulans.,2015,10.1007/s12275-015-4701-8,https://pubmed.ncbi.nlm.nih.gov/25626364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX3A,ENSG00000169059,CTA,22583828,Array-CGH characterization of a de novo t(X;Y)(p22;q11) in a female with short stature and mental retardation.,2012,10.1016/j.gene.2012.05.009,https://pubmed.ncbi.nlm.nih.gov/22583828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX3A,ENSG00000169059,CTA,19200188,Atypical X-linked ichthyosis in a patient with a large deletion involving the steroid sulfatase (STS) gene.,2009,10.1111/j.1365-4632.2009.03996.x,https://pubmed.ncbi.nlm.nih.gov/19200188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX3B,ENSG00000205642,CTA,36513788,Transcriptomic differences between fibrotic and non-fibrotic testicular tissue reveal possible key players in Klinefelter syndrome-related testicular fibrosis.,2022,10.1038/s41598-022-26011-6,https://pubmed.ncbi.nlm.nih.gov/36513788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX3B,ENSG00000205642,CTA,39834547,An investigation of a hemophilia A female with heterozygous intron 22 inversion and skewed X chromosome inactivation.,2024,10.3389/fgene.2024.1500167,https://pubmed.ncbi.nlm.nih.gov/39834547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX3B,ENSG00000205642,CTA,28122887,Expanding the genetic spectrum of ANOS1 mutations in patients with congenital hypogonadotropic hypogonadism.,2017,10.1093/humrep/dew354,https://pubmed.ncbi.nlm.nih.gov/28122887/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX3B,ENSG00000205642,CTA,18076704,"Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis.",2008,10.1111/j.1365-2133.2007.08373.x,https://pubmed.ncbi.nlm.nih.gov/18076704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX3B,ENSG00000205642,CTA,10449781,Cytomegalovirus encodes a potent alpha chemokine.,1999,10.1073/pnas.96.17.9839,https://pubmed.ncbi.nlm.nih.gov/10449781/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,40459262,VCY mediates inhibition of PFV replication via interaction with the transcription activator Tas.,2025,10.1128/jvi.00166-25,https://pubmed.ncbi.nlm.nih.gov/40459262/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,37967251,Transcript Isoform Diversity of Ampliconic Genes on the Y Chromosome of Great Apes.,2023,10.1093/gbe/evad205,https://pubmed.ncbi.nlm.nih.gov/37967251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,36751648,"Cumulative Human Immunodeficiency Virus (HIV)-1 Viremia Is Associated With Increased Risk of Multimorbidity Among US Women With HIV, 1997-2019.",2023,10.1093/ofid/ofac702,https://pubmed.ncbi.nlm.nih.gov/36751648/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,38957643,Delayed hypersensitivity reaction after hyaluronic acid filler (VCY-20).,2024,10.4081/dr.2023.9800,https://pubmed.ncbi.nlm.nih.gov/38957643/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,33766143,Human AZFb deletions cause distinct testicular pathologies depending on their extensions in Yq11 and the Y haplogroup: new cases and review of literature.,2021,10.1186/s13578-021-00551-2,https://pubmed.ncbi.nlm.nih.gov/33766143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,33057418,Viremia copy-years and risk of estimated glomerular filtration rate reduction in adults living with perinatal HIV infection.,2020,10.1371/journal.pone.0240550,https://pubmed.ncbi.nlm.nih.gov/33057418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,40077468,"Isolation and Characterization of Enterocin-Producing &lt;i&gt;Enterococcus faecium&lt;/i&gt; Strains from Algerian Traditional Food ""Dried Figs Marinated in Olive Oil"": Functional and Safety Evaluations.",2025,10.3390/foods14050766,https://pubmed.ncbi.nlm.nih.gov/40077468/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,31610793,"Birth, expansion, and death of VCY-containing palindromes on the human Y chromosome.",2019,10.1186/s13059-019-1816-y,https://pubmed.ncbi.nlm.nih.gov/31610793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,29453317,Histone H3.3K27M Mobilizes Multiple Cancer/Testis (CT) Antigens in Pediatric Glioma.,2018,10.1158/1541-7786.mcr-17-0460,https://pubmed.ncbi.nlm.nih.gov/29453317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,32003696,Cumulative HIV Viremia Copy-Years and Hypertension in People Living with HIV.,2020,10.2174/1570162x18666200131122206,https://pubmed.ncbi.nlm.nih.gov/32003696/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,30760267,Genomic evidence of Y chromosome microchimerism in the endometrium during endometriosis and in cases of infertility.,2019,10.1186/s12958-019-0465-z,https://pubmed.ncbi.nlm.nih.gov/30760267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,30234792,HIV Viremia During Pregnancy and Neurodevelopment of HIV-Exposed Uninfected Children in the Context of Universal Antiretroviral Therapy and Breastfeeding: A Prospective Study.,2019,10.1097/inf.0000000000002193,https://pubmed.ncbi.nlm.nih.gov/30234792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,25799347,De novo origin of VCY2 from autosome to Y-transposed amplicon.,2015,10.1371/journal.pone.0119651,https://pubmed.ncbi.nlm.nih.gov/25799347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,33650819,The Contribution of Y Chromosome Genes to Spontaneous Differentiation of Human Embryonic Stem Cells into Embryoid Bodies In Vitro.,2021,10.22074/cellj.2021.7145,https://pubmed.ncbi.nlm.nih.gov/33650819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,27116045,Limiting Cumulative HIV Viremia Copy-Years by Early Treatment Reduces Risk of AIDS and Death.,2016,10.1097/qai.0000000000001029,https://pubmed.ncbi.nlm.nih.gov/27116045/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,26843068,Viral load monitoring and antiretroviral treatment outcomes in a pediatric HIV cohort in Ghana.,2016,10.1186/s12879-016-1402-9,https://pubmed.ncbi.nlm.nih.gov/26843068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,12862317,Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis.,2003,10.1038/sj.cr.7290161,https://pubmed.ncbi.nlm.nih.gov/12862317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,16784771,Presence of TSPY transcript and absence of transcripts of other Y chromosomal genes in a case of microscopic gonadoblastoma.,2006,10.1016/j.ygyno.2006.05.010,https://pubmed.ncbi.nlm.nih.gov/16784771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,22020507,"High frequency of a novel filamentous phage, VCY φ, within an environmental Vibrio cholerae population.",2012,10.1128/aem.06297-11,https://pubmed.ncbi.nlm.nih.gov/22020507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,10903929,"A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation.",2000,10.1086/303047,https://pubmed.ncbi.nlm.nih.gov/10903929/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY,ENSG00000129864,CTA,30379686,Viremia copy-years and mortality among combination antiretroviral therapy-initiating HIV-positive individuals: how much viral load history is enough?,2018,10.1097/qad.0000000000001986,https://pubmed.ncbi.nlm.nih.gov/30379686/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY1B,ENSG00000129862,CTA,33766143,Human AZFb deletions cause distinct testicular pathologies depending on their extensions in Yq11 and the Y haplogroup: new cases and review of literature.,2021,10.1186/s13578-021-00551-2,https://pubmed.ncbi.nlm.nih.gov/33766143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY1B,ENSG00000129862,CTA,16784771,Presence of TSPY transcript and absence of transcripts of other Y chromosomal genes in a case of microscopic gonadoblastoma.,2006,10.1016/j.ygyno.2006.05.010,https://pubmed.ncbi.nlm.nih.gov/16784771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY1B,ENSG00000129862,CTA,11743352,DNA methylation regulates the expression of Y chromosome specific genes in prostate cancer.,2002,10.1016/s0022-5347(05)65464-x,https://pubmed.ncbi.nlm.nih.gov/11743352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY1B,ENSG00000129862,CTA,11257712,Expression analysis of Y chromosome genes in human prostate cancer.,2001,10.1016/s0022-5347(01)69895-1,https://pubmed.ncbi.nlm.nih.gov/11257712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY1B,ENSG00000129862,CTA,10747295,Expression analysis of thirty one Y chromosome genes in human prostate cancer.,2000,10.1002/(sici)1098-2744(200004)27:4<308::aid-mc9>3.0.co;2-r,https://pubmed.ncbi.nlm.nih.gov/10747295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCY1B,ENSG00000129862,CTA,10607842,A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins.,2000,10.1093/hmg/9.2.311,https://pubmed.ncbi.nlm.nih.gov/10607842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR87,ENSG00000171804,CTA,36571501,WDR87 interacts with CFAP47 protein in the middle piece of spermatozoa flagella to participate in sperm tail assembly.,2022,10.1093/molehr/gaac042,https://pubmed.ncbi.nlm.nih.gov/36571501/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR87,ENSG00000171804,CTA,42010917,Integrative Multiomics Approaches Identify Biomarkers Associated With Progression From Arthralgia to Rheumatoid Arthritis.,2026,10.1002/art.70194,https://pubmed.ncbi.nlm.nih.gov/42010917/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR87,ENSG00000171804,CTA,34620846,"Genomic alterations associated with mutational signatures, DNA damage repair and chromatin remodeling pathways in cervical carcinoma.",2021,10.1038/s41525-021-00244-2,https://pubmed.ncbi.nlm.nih.gov/34620846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR87,ENSG00000171804,CTA,27878435,Novel phenotypes and loci identified through clinical genomics approaches to pediatric cataract.,2017,10.1007/s00439-016-1747-6,https://pubmed.ncbi.nlm.nih.gov/27878435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR87,ENSG00000171804,CTA,26622071,Phenotypes of Recessive Pediatric Cataract in a Cohort of Children with Identified Homozygous Gene Mutations (An American Ophthalmological Society Thesis).,2015,,https://pubmed.ncbi.nlm.nih.gov/26622071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC10A,ENSG00000180305,CTA,41886499,"Repurposing mebendazole to reprogram oncogenic and tumor-suppressor networks: Multi-cancer insights from ENOX2, MMP2, RASSF1A, WFDC10A and METTL7A.",2026,10.1371/journal.pone.0345701,https://pubmed.ncbi.nlm.nih.gov/41886499/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC10A,ENSG00000180305,CTA,42295288,Mendelian Randomization and Transcriptomic Analysis Identify HE4 as a Potential Biomarker for Chronic Obstructive Pulmonary Disease.,2026,10.7754/clin.lab.2025.250536,https://pubmed.ncbi.nlm.nih.gov/42295288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC10A,ENSG00000180305,CTA,39665756,Large-scale CRISPR/Cas9 deletions within the WFDC gene cluster uncover gene functionality and critical roles in mammalian reproduction.,2024,10.1073/pnas.2413195121,https://pubmed.ncbi.nlm.nih.gov/39665756/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC10A,ENSG00000180305,CTA,16996203,Differential expression and antibacterial activity of WFDC10A in the monkey epididymis.,2006,10.1016/j.mce.2006.08.003,https://pubmed.ncbi.nlm.nih.gov/16996203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC6,ENSG00000243543,CTA,39665756,Large-scale CRISPR/Cas9 deletions within the WFDC gene cluster uncover gene functionality and critical roles in mammalian reproduction.,2024,10.1073/pnas.2413195121,https://pubmed.ncbi.nlm.nih.gov/39665756/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC6,ENSG00000243543,CTA,24356879,Sequence diversity of Pan troglodytes subspecies and the impact of WFDC6 selective constraints in reproductive immunity.,2013,10.1093/gbe/evt198,https://pubmed.ncbi.nlm.nih.gov/24356879/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC6,ENSG00000243543,CTA,21536719,Differing evolutionary histories of WFDC8 (short-term balancing) in Europeans and SPINT4 (incomplete selective sweep) in Africans.,2011,10.1093/molbev/msr106,https://pubmed.ncbi.nlm.nih.gov/21536719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,41176051,Cancer-testis antigens (CTAs) in lung cancer.,2026,10.1016/j.cca.2025.120687,https://pubmed.ncbi.nlm.nih.gov/41176051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,35027975,Cancer testis antigen XAGE-1 is a promising marker for the diagnosis and treatment of ovarian cancer.,2021,10.25122/jml-2021-0304,https://pubmed.ncbi.nlm.nih.gov/35027975/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,38964205,Automated immunoassay of serum NY-ESO-1 and XAGE1 antibodies for predicting clinical benefit with immune checkpoint inhibitor (ICI) in advanced non-small cell lung cancer.,2024,10.1016/j.ctarc.2024.100830,https://pubmed.ncbi.nlm.nih.gov/38964205/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,37081973,Tumor immune microenvironment of cutaneous angiosarcoma with cancer testis antigens and the formation of tertiary lymphoid structures.,2023,10.3389/fonc.2023.1106434,https://pubmed.ncbi.nlm.nih.gov/37081973/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,36642483,Immune checkpoint therapy and response biomarkers in non-small-cell lung cancer: Serum NY-ESO-1 and XAGE1 antibody as predictive and monitoring markers.,2023,10.1016/bs.acc.2022.09.004,https://pubmed.ncbi.nlm.nih.gov/36642483/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,33293354,Role of immunotherapy in Ewing sarcoma.,2020,10.1136/jitc-2020-000653,https://pubmed.ncbi.nlm.nih.gov/33293354/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,33865813,A novel automated immunoassay for serum NY-ESO-1 and XAGE1 antibodies in combinatory prediction of response to anti-programmed cell death-1 therapy in non-small-cell lung cancer.,2021,10.1016/j.cca.2021.04.008,https://pubmed.ncbi.nlm.nih.gov/33865813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,34600138,"Measurable Residual Disease Monitoring of SPAG6, ST18, PRAME, and XAGE1A Expression in Peripheral Blood May Detect Imminent Relapse in Childhood Acute Myeloid Leukemia.",2021,10.1016/j.jmoldx.2021.09.004,https://pubmed.ncbi.nlm.nih.gov/34600138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,29577858,Expression and Prognostic Relevance of GAGE1 and XAGE1 Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma.,2017,10.2174/1566524018666180322162145,https://pubmed.ncbi.nlm.nih.gov/29577858/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,35616661,Serum Biomarker Panel for Rapid Early Diagnosis of Lung Cancer.,2023,10.2174/1568009622666220523154333,https://pubmed.ncbi.nlm.nih.gov/35616661/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,31449889,Serum Antibody Against NY-ESO-1 and XAGE1 Antigens Potentially Predicts Clinical Responses to Anti-Programmed Cell Death-1 Therapy in NSCLC.,2019,10.1016/j.jtho.2019.08.008,https://pubmed.ncbi.nlm.nih.gov/31449889/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,27799141,"Survival of Lung Adenocarcinoma Patients Predicted from Expression of PD-L1, Galectin-9, and XAGE1 (GAGED2a) on Tumor Cells and Tumor-Infiltrating T Cells.",2016,10.1158/2326-6066.cir-15-0266,https://pubmed.ncbi.nlm.nih.gov/27799141/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,22870117,Hepatocellular carcinoma patients highly and specifically expressing XAGE-1 exhibit prolonged survival.,2010,10.3892/ol.2010.175,https://pubmed.ncbi.nlm.nih.gov/22870117/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,25124687,Prolongation of overall survival in advanced lung adenocarcinoma patients with the XAGE1 (GAGED2a) antibody.,2014,10.1158/1078-0432.ccr-14-0742,https://pubmed.ncbi.nlm.nih.gov/25124687/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,28105694,Lack of XAGE-1b and NY-ESO-1 in metastatic lymph nodes may predict the potential survival of stage III melanoma patients.,2017,10.1111/1346-8138.13730,https://pubmed.ncbi.nlm.nih.gov/28105694/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,24970476,"A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets.",2014,10.1158/0008-5472.can-13-3725,https://pubmed.ncbi.nlm.nih.gov/24970476/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,28631709,[Cancer-testis genes in colon cancer].,2017,10.17116/terarkh2017895113-117,https://pubmed.ncbi.nlm.nih.gov/28631709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,24973179,Common Ewing sarcoma-associated antigens fail to induce natural T cell responses in both patients and healthy individuals.,2014,10.1007/s00262-014-1574-3,https://pubmed.ncbi.nlm.nih.gov/24973179/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,25279215,XAGE-1b expression is associated with the diagnosis and early recurrence of hepatocellular carcinoma.,2014,10.3892/mco.2014.336,https://pubmed.ncbi.nlm.nih.gov/25279215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,25941600,Antibody response to cancer/testis (CT) antigens: A prognostic marker in cancer patients.,2014,10.4161/21624011.2014.970032,https://pubmed.ncbi.nlm.nih.gov/25941600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,23625514,Effects of CT-Xp gene knock down in melanoma cell lines.,2013,10.18632/oncotarget.921,https://pubmed.ncbi.nlm.nih.gov/23625514/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,29058705,Identification of a gene expression signature associated with the metastasis suppressor function of NME1: prognostic value in human melanoma.,2018,10.1038/labinvest.2017.108,https://pubmed.ncbi.nlm.nih.gov/29058705/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,16061866,XAGE-1 expression in non-small cell lung cancer and antibody response in patients.,2005,10.1158/1078-0432.ccr-05-0216,https://pubmed.ncbi.nlm.nih.gov/16061866/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,15905609,XAGE-1 mRNA expression in prostate cancer and antibody response in patients.,2005,10.1111/j.1348-0421.2005.tb03751.x,https://pubmed.ncbi.nlm.nih.gov/15905609/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1A,ENSG00000204379,CTA,12479262,"Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers.",2002,,https://pubmed.ncbi.nlm.nih.gov/12479262/,annotation citations | therapy,Discussed in explicit gene adjudication; see its review depth and limitations
XAGE1A,ENSG00000204379,CTA,17335148,Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors.,2007,,https://pubmed.ncbi.nlm.nih.gov/17335148/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
XAGE1B,ENSG00000204382,CTA,41176051,Cancer-testis antigens (CTAs) in lung cancer.,2026,10.1016/j.cca.2025.120687,https://pubmed.ncbi.nlm.nih.gov/41176051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,35027975,Cancer testis antigen XAGE-1 is a promising marker for the diagnosis and treatment of ovarian cancer.,2021,10.25122/jml-2021-0304,https://pubmed.ncbi.nlm.nih.gov/35027975/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,38964205,Automated immunoassay of serum NY-ESO-1 and XAGE1 antibodies for predicting clinical benefit with immune checkpoint inhibitor (ICI) in advanced non-small cell lung cancer.,2024,10.1016/j.ctarc.2024.100830,https://pubmed.ncbi.nlm.nih.gov/38964205/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,37081973,Tumor immune microenvironment of cutaneous angiosarcoma with cancer testis antigens and the formation of tertiary lymphoid structures.,2023,10.3389/fonc.2023.1106434,https://pubmed.ncbi.nlm.nih.gov/37081973/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,36642483,Immune checkpoint therapy and response biomarkers in non-small-cell lung cancer: Serum NY-ESO-1 and XAGE1 antibody as predictive and monitoring markers.,2023,10.1016/bs.acc.2022.09.004,https://pubmed.ncbi.nlm.nih.gov/36642483/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,33293354,Role of immunotherapy in Ewing sarcoma.,2020,10.1136/jitc-2020-000653,https://pubmed.ncbi.nlm.nih.gov/33293354/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,33865813,A novel automated immunoassay for serum NY-ESO-1 and XAGE1 antibodies in combinatory prediction of response to anti-programmed cell death-1 therapy in non-small-cell lung cancer.,2021,10.1016/j.cca.2021.04.008,https://pubmed.ncbi.nlm.nih.gov/33865813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,35804987,"Analysis of Exosomal Cargo Provides Accurate Clinical, Histologic and Mutational Information in Non-Small Cell Lung Cancer.",2022,10.3390/cancers14133216,https://pubmed.ncbi.nlm.nih.gov/35804987/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,36843840,CRISPR activation screening in a mouse model for drivers of hepatocellular carcinoma growth and metastasis.,2023,10.1016/j.isci.2023.106099,https://pubmed.ncbi.nlm.nih.gov/36843840/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,29577858,Expression and Prognostic Relevance of GAGE1 and XAGE1 Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma.,2017,10.2174/1566524018666180322162145,https://pubmed.ncbi.nlm.nih.gov/29577858/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,30093970,A k-mer based transcriptomics approach for antisense drug discovery targeting the Ewing's family of tumors.,2018,10.18632/oncotarget.25736,https://pubmed.ncbi.nlm.nih.gov/30093970/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,31449889,Serum Antibody Against NY-ESO-1 and XAGE1 Antigens Potentially Predicts Clinical Responses to Anti-Programmed Cell Death-1 Therapy in NSCLC.,2019,10.1016/j.jtho.2019.08.008,https://pubmed.ncbi.nlm.nih.gov/31449889/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,27799141,"Survival of Lung Adenocarcinoma Patients Predicted from Expression of PD-L1, Galectin-9, and XAGE1 (GAGED2a) on Tumor Cells and Tumor-Infiltrating T Cells.",2016,10.1158/2326-6066.cir-15-0266,https://pubmed.ncbi.nlm.nih.gov/27799141/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,35651938,Identification of Novel Characteristics in TP53-Mutant Hepatocellular Carcinoma Using Bioinformatics.,2022,10.3389/fgene.2022.874805,https://pubmed.ncbi.nlm.nih.gov/35651938/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,22870117,Hepatocellular carcinoma patients highly and specifically expressing XAGE-1 exhibit prolonged survival.,2010,10.3892/ol.2010.175,https://pubmed.ncbi.nlm.nih.gov/22870117/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,25124687,Prolongation of overall survival in advanced lung adenocarcinoma patients with the XAGE1 (GAGED2a) antibody.,2014,10.1158/1078-0432.ccr-14-0742,https://pubmed.ncbi.nlm.nih.gov/25124687/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,28105694,Lack of XAGE-1b and NY-ESO-1 in metastatic lymph nodes may predict the potential survival of stage III melanoma patients.,2017,10.1111/1346-8138.13730,https://pubmed.ncbi.nlm.nih.gov/28105694/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,24970476,"A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets.",2014,10.1158/0008-5472.can-13-3725,https://pubmed.ncbi.nlm.nih.gov/24970476/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,28631709,[Cancer-testis genes in colon cancer].,2017,10.17116/terarkh2017895113-117,https://pubmed.ncbi.nlm.nih.gov/28631709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,24973179,Common Ewing sarcoma-associated antigens fail to induce natural T cell responses in both patients and healthy individuals.,2014,10.1007/s00262-014-1574-3,https://pubmed.ncbi.nlm.nih.gov/24973179/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,25941600,Antibody response to cancer/testis (CT) antigens: A prognostic marker in cancer patients.,2014,10.4161/21624011.2014.970032,https://pubmed.ncbi.nlm.nih.gov/25941600/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,23625514,Effects of CT-Xp gene knock down in melanoma cell lines.,2013,10.18632/oncotarget.921,https://pubmed.ncbi.nlm.nih.gov/23625514/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE1B,ENSG00000204382,CTA,17335148,Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors.,2007,,https://pubmed.ncbi.nlm.nih.gov/17335148/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
XAGE1B,ENSG00000204382,CTA,12479262,"Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers.",2002,,https://pubmed.ncbi.nlm.nih.gov/12479262/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
YBX2,ENSG00000006047,CTA,42634447,Acute Dietary Zinc Deficiency Impairs Sperm Motility but Not Gonadal mRNA Methylation in Mice.,2026,10.1002/mrd.70144,https://pubmed.ncbi.nlm.nih.gov/42634447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,41426208,Knockdown of Y-box-binding protein 2 induces mitochondrial dysfunction to interrupt zygotic genome activation in porcine embryos.,2025,10.5187/jast.2024.e87,https://pubmed.ncbi.nlm.nih.gov/41426208/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,42011916,NSUN5 Attenuates Renal Injury and Ferroptosis in Hyperuricaemic Nephropathy Through YBX2-Dependent Stabilisation of SCD1 m5C Methylation.,2026,10.1002/advs.202521459,https://pubmed.ncbi.nlm.nih.gov/42011916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,39909973,Identification of YBX2 and TSKS As STK33 Interacting Proteins in Testicular Germ Cells.,2025,10.1007/s43032-025-01798-7,https://pubmed.ncbi.nlm.nih.gov/39909973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,40505347,"Uremic toxin receptor NR1H3 contributes to hyperlipidemia- and chronic kidney disease-accelerated vascular inflammation, which is partially suppressed by novel YBX2 anti-ROS pathway.",2025,10.1016/j.redox.2025.103724,https://pubmed.ncbi.nlm.nih.gov/40505347/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,40918643,Analysis of the mRNA modification machinery alterations in breast cancer through the SCAN-B cohort.,2025,10.1093/narcan/zcaf027,https://pubmed.ncbi.nlm.nih.gov/40918643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,41350940,IGF2BP3 recognizes m&lt;sup&gt;6&lt;/sup&gt;A to regulate histone-to-protamine replacement during mouse sperm development.,2026,10.1038/s44318-025-00659-y,https://pubmed.ncbi.nlm.nih.gov/41350940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,39201790,Comprehensive Analysis of Methylome and Transcriptome to Identify Potential Genes Regulating Porcine Testis Development.,2024,10.3390/ijms25169105,https://pubmed.ncbi.nlm.nih.gov/39201790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,42890222,Stage-specific transcriptional atlas of goose satellite cells uncovers sex-biased molecular dynamics associated with embryonic skeletal muscle development.,2026,10.3389/fcell.2026.1957937,https://pubmed.ncbi.nlm.nih.gov/42890222/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,42698848,"YBX1 as an adaptive RNA hub in cancer: linking state-dependent RNA regulation to tumor immunity, metabolic reprogramming, and therapy resistance.",2026,10.3389/fimmu.2026.1926363,https://pubmed.ncbi.nlm.nih.gov/42698848/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,39667612,"A testis-specific long non-coding RNA, 1700052I22Rik, regulates spermatid chromatin condensation in mice.",2025,10.1016/j.biocel.2024.106725,https://pubmed.ncbi.nlm.nih.gov/39667612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,41866013,"Formaldehyde activates the RUNX1-ISX axis to promote leukemic reprogramming, a pathway associated with poor prognosis in pediatric B-ALL.",2026,10.1016/j.envpol.2026.127969,https://pubmed.ncbi.nlm.nih.gov/41866013/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,38698857,Comprehensive pan-cancer analysis of YBX family reveals YBX2 as a potential biomarker in liver cancer.,2024,10.3389/fimmu.2024.1382520,https://pubmed.ncbi.nlm.nih.gov/38698857/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,39990690,Biological functions of 5-methylcytosine RNA-binding proteins and their potential mechanisms in human cancers.,2025,10.3389/fonc.2025.1534948,https://pubmed.ncbi.nlm.nih.gov/39990690/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,37860762,Phosphorylated YBX2 is stabilized to promote glycolysis in brown adipocytes.,2023,10.1016/j.isci.2023.108091,https://pubmed.ncbi.nlm.nih.gov/37860762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,42264465,Integrative Multi-Omics Analysis Identifies Novel Enhancer Variants on SSC2 Associated With Backfat Thickness in Landrace Pigs.,2026,10.1002/age.70141,https://pubmed.ncbi.nlm.nih.gov/42264465/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,33602962,"YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer.",2021,10.1038/s41598-021-83200-5,https://pubmed.ncbi.nlm.nih.gov/33602962/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,36964127,The m6A reader PRRC2A is essential for meiosis I completion during spermatogenesis.,2023,10.1038/s41467-023-37252-y,https://pubmed.ncbi.nlm.nih.gov/36964127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,37030331,YBX2 modulates mRNA stability via interaction with YTHDF2 in endometrial cancer cells.,2023,10.1016/j.yexcr.2023.113586,https://pubmed.ncbi.nlm.nih.gov/37030331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,34819492,Pseudogene RPL32P3 regulates the blood-tumor barrier permeability via the YBX2/HNF4G axis.,2021,10.1038/s41420-021-00758-9,https://pubmed.ncbi.nlm.nih.gov/34819492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,33638948,"Integrative analysis of genomic, epigenomic and transcriptomic data identified molecular subtypes of esophageal carcinoma.",2021,10.18632/aging.202556,https://pubmed.ncbi.nlm.nih.gov/33638948/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,34745933,Prognostic and Predictive Value of Transcription Factors Panel for Digestive System Carcinoma.,2021,10.3389/fonc.2021.670129,https://pubmed.ncbi.nlm.nih.gov/34745933/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,33589575,Development and validation of RNA binding protein-applied prediction model for gastric cancer.,2021,10.18632/aging.202483,https://pubmed.ncbi.nlm.nih.gov/33589575/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,32021278,Transcriptome Analysis Reveals Key Genes and Pathways Associated with Metastasis in Breast Cancer.,2020,10.2147/ott.s226770,https://pubmed.ncbi.nlm.nih.gov/32021278/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YBX2,ENSG00000006047,CTA,16479255,"Expression of Y-box-binding protein dbpC/contrin, a potentially new cancer/testis antigen.",2006,10.1038/sj.bjc.6602987,https://pubmed.ncbi.nlm.nih.gov/16479255/,annotation citations,Discussed in explicit gene adjudication; see its review depth and limitations
YBX2,ENSG00000006047,CTA,10100484,"Contrin, the human homologue of a germ-cell Y-box-binding protein: cloning, expression, and chromosomal localization.",1999,10.1002/j.1939-4640.1999.tb02506.x,https://pubmed.ncbi.nlm.nih.gov/10100484/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCCHC13,ENSG00000187969,CTA,41246941,Epigenetic Disruption as a Molecular Signature in Idiopathic Nonobstructive Azoospermia.,2025,10.1177/15579883251389793,https://pubmed.ncbi.nlm.nih.gov/41246941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCCHC13,ENSG00000187969,CTA,42154653,Long non-coding RNA expression profiles in neutrophils revealed potential biomarker for rapidly progressive interstitial lung disease in MDA5+ dermatomyositis.,2026,10.55563/clinexprheumatol/qde1o3,https://pubmed.ncbi.nlm.nih.gov/42154653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCCHC13,ENSG00000187969,CTA,39932629,Genetic insights into non-obstructive azoospermia: Implications for diagnosis and TESE outcomes.,2025,10.1007/s10815-025-03409-5,https://pubmed.ncbi.nlm.nih.gov/39932629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCCHC13,ENSG00000187969,CTA,30940166,ZCCHC13-mediated induction of human liver cancer is associated with the modulation of DNA methylation and the AKT/ERK signaling pathway.,2019,10.1186/s12967-019-1852-0,https://pubmed.ncbi.nlm.nih.gov/30940166/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCCHC13,ENSG00000187969,CTA,29531833,Novel biomarker ZCCHC13 revealed by integrating DNA methylation and mRNA expression data in non-obstructive azoospermia.,2018,10.1038/s41420-018-0033-x,https://pubmed.ncbi.nlm.nih.gov/29531833/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCCHC13,ENSG00000187969,CTA,36183055,Breast cancer prediction with transcriptome profiling using feature selection and machine learning methods.,2022,10.1186/s12859-022-04965-8,https://pubmed.ncbi.nlm.nih.gov/36183055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCCHC13,ENSG00000187969,CTA,35835407,X chromosome-linked genes in the mature sperm influence semen quality and fertility of breeding bulls.,2022,10.1016/j.gene.2022.146727,https://pubmed.ncbi.nlm.nih.gov/35835407/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCCHC13,ENSG00000187969,CTA,23940725,Identification of an imprinted gene cluster in the X-inactivation center.,2013,10.1371/journal.pone.0071222,https://pubmed.ncbi.nlm.nih.gov/23940725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNRF4,ENSG00000105428,CTA,35159190,From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in Disease.,2022,10.3390/cells11030380,https://pubmed.ncbi.nlm.nih.gov/35159190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNRF4,ENSG00000105428,CTA,28656966,E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.,2017,10.1038/ncomms15865,https://pubmed.ncbi.nlm.nih.gov/28656966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNRF4,ENSG00000105428,CTA,21205830,A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis.,2011,10.1074/jbc.m110.197459,https://pubmed.ncbi.nlm.nih.gov/21205830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSWIM2,ENSG00000163012,CTA,35831855,The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice.,2022,10.1186/s12915-022-01368-2,https://pubmed.ncbi.nlm.nih.gov/35831855/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSWIM2,ENSG00000163012,CTA,36355490,The Expression Patterns of Human Cancer-Testis Genes Are Induced through Epigenetic Drugs in Colon Cancer Cells.,2022,10.3390/ph15111319,https://pubmed.ncbi.nlm.nih.gov/36355490/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,42385916,KIAA0101 in human cancers: From biomarker discovery to therapeutic targeting.,2026,10.1016/j.bbcan.2026.189648,https://pubmed.ncbi.nlm.nih.gov/42385916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,42329914,Tumor-associated M2 macrophages promote prostate cancer invasion through the M-CSF-PCLAF pathway.,2026,10.1371/journal.pone.0351858,https://pubmed.ncbi.nlm.nih.gov/42329914/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,40681332,Inhibition of &lt;i&gt;KIAA0101&lt;/i&gt; Expression Can Regulate Cell Proliferation and Apoptosis in Colon Cancer.,2025,10.1089/cbr.2025.0108,https://pubmed.ncbi.nlm.nih.gov/40681332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,42589442,MicroRNA Signatures of Fulvestrant-Treated Luminal Breast Cancer Cells: Identification of Therapeutic Targets Regulated by &lt;i&gt;miR-374b-5p&lt;/i&gt;.,2026,10.3390/ijms27156787,https://pubmed.ncbi.nlm.nih.gov/42589442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,41807518,Dissecting the differentiation origins of intestinal metaplasia and early intestinal-type gastric cancer in gastric antrum by single-cell RNA profiling.,2026,10.1038/s41698-026-01355-8,https://pubmed.ncbi.nlm.nih.gov/41807518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,36915794,Beta-catenin knockdown impairs the viability of ovarian cancer cells by modulating YAP-dependent glycolysis.,2023,,https://pubmed.ncbi.nlm.nih.gov/36915794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,40546347,Network-based analysis of candidate oncogenes and pathways in hepatocellular carcinoma.,2025,10.1016/j.bbrep.2025.102086,https://pubmed.ncbi.nlm.nih.gov/40546347/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,39935848,Diagnosis of hepatocellular carcinoma using liquid biopsy-based biomarkers: a systematic review and network meta-analysis.,2024,10.3389/fonc.2024.1483521,https://pubmed.ncbi.nlm.nih.gov/39935848/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,36705420,Knockdown of LINC01138 protects human chondrocytes against IL-1β-induced damage by regulating the hsa-miR-1207-5p/KIAA0101 axis.,2023,10.1002/iid3.744,https://pubmed.ncbi.nlm.nih.gov/36705420/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,38279448,KIAA0101 promotes cisplatin resistance through regulating cell apoptosis in lung cancer cells.,2023,10.14715/cmb/2023.69.14.28,https://pubmed.ncbi.nlm.nih.gov/38279448/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,32901882,MicroRNA‑216a‑5p suppresses esophageal squamous cell carcinoma progression by targeting KIAA0101.,2020,10.3892/or.2020.7751,https://pubmed.ncbi.nlm.nih.gov/32901882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,36499614,Identification of Novel Hub Genes Associated with Psoriasis Using Integrated Bioinformatics Analysis.,2022,10.3390/ijms232315286,https://pubmed.ncbi.nlm.nih.gov/36499614/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,35524161,Circ_0005231 promotes the progression of esophageal squamous cell carcinoma via sponging miR-383-5p and regulating KIAA0101.,2022,10.1111/1759-7714.14450,https://pubmed.ncbi.nlm.nih.gov/35524161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,36164371,KIAA0101 and IL2RA Were Identified as Core Genes in Hormone-Resistant Nephropathy.,2022,10.1155/2022/6545266,https://pubmed.ncbi.nlm.nih.gov/36164371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,34792707,KIAA0101 knockdown inhibits glioma progression and glycolysis by inactivating the PI3K/AKT/mTOR pathway.,2022,10.1007/s11011-021-00863-9,https://pubmed.ncbi.nlm.nih.gov/34792707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,37526191,Evaluation of Therapeutic Mechanism of Hedyotis Diffusa Willd (HDW)‒ Scutellaria Barbata (SB) in Clear Cell Renal Cell Carcinoma &lt;i&gt;via&lt;/i&gt; Singlecell RNA Sequencing and Network Pharmacology.,2024,10.2174/1386207326666230731155309,https://pubmed.ncbi.nlm.nih.gov/37526191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,35116699,Increased KIAA0101 gene expression associated with poor prognosis in breast cancer.,2021,10.21037/tcr-20-3064,https://pubmed.ncbi.nlm.nih.gov/35116699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,39323031,Comprehensive Analysis Identifies Hyaluronan Mediated Motility Receptor and Cell Division Cycle 25C as Potential Prognostic Biomarkers in Head and Neck Squamous Cell Carcinoma.,2024,10.1177/10732748241287904,https://pubmed.ncbi.nlm.nih.gov/39323031/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,33708887,Kiaa0101 serves as a prognostic marker and promotes invasion by regulating p38/snail1 pathway in glioma.,2021,10.21037/atm-20-3219,https://pubmed.ncbi.nlm.nih.gov/33708887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,34296306,Circular RNA TADA2A promotes proliferation and migration via modulating of miR‑638/KIAA0101 signal in non‑small cell lung cancer.,2021,10.3892/or.2021.8152,https://pubmed.ncbi.nlm.nih.gov/34296306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,33231570,"KIAA0101 as a new diagnostic and prognostic marker, and its correlation with gene regulatory networks and immune infiltrates in lung adenocarcinoma.",2020,10.18632/aging.104144,https://pubmed.ncbi.nlm.nih.gov/33231570/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,35504200,Identifying novel tumor-related antigens and immune phenotypes for developing mRNA vaccines in lung adenocarcinoma.,2022,10.1016/j.intimp.2022.108816,https://pubmed.ncbi.nlm.nih.gov/35504200/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,33046987,Overexpression of KIAA0101 Promotes the Progression of Non-small Cell Lung Cancer.,2020,10.7150/jca.45962,https://pubmed.ncbi.nlm.nih.gov/33046987/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,33850884,KIAA0101 knockdown inhibits cell proliferation and induces cell cycle arrest and cell apoptosis in chronic lymphocytic leukemia cells.,2021,10.21037/atm-21-626,https://pubmed.ncbi.nlm.nih.gov/33850884/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,39239040,Esophageal chemical burns as a risk factor for esophageal malignancies: in-silico analyses - experimental research.,2024,10.1097/ms9.0000000000002317,https://pubmed.ncbi.nlm.nih.gov/39239040/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,36224755,"Identification and Validation of Novel Biomarkers and Potential Targeted Drugs in Cholangiocarcinoma: Bioinformatics, Virtual Screening, and Biological Evaluation.",2022,10.4014/jmb.2207.07037,https://pubmed.ncbi.nlm.nih.gov/36224755/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,37828118,"Advanced stage, high-grade primary tumor ovarian cancer: a multi-omics dissection and biomarker prediction process.",2023,10.1038/s41598-023-44246-9,https://pubmed.ncbi.nlm.nih.gov/37828118/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,23698777,NS5ATP9 contributes to inhibition of cell proliferation by hepatitis C virus (HCV) nonstructural protein 5A (NS5A) via MEK/extracellular signal regulated kinase (ERK) pathway.,2013,10.3390/ijms140510539,https://pubmed.ncbi.nlm.nih.gov/23698777/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,36176446,Identification and verification of hub genes associated with the progression of non-small cell lung cancer by integrated analysis.,2022,10.3389/fphar.2022.997842,https://pubmed.ncbi.nlm.nih.gov/36176446/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,32059076,Identification and validation of key genes with prognostic value in non-small-cell lung cancer via integrated bioinformatics analysis.,2020,10.1111/1759-7714.13298,https://pubmed.ncbi.nlm.nih.gov/32059076/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,33626321,PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis.,2021,10.1016/j.molcel.2021.02.001,https://pubmed.ncbi.nlm.nih.gov/33626321/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,31681434,Mining Public Toxicogenomic Data Reveals Insights and Challenges in Delineating Liver Steatosis Adverse Outcome Pathways.,2019,10.3389/fgene.2019.01007,https://pubmed.ncbi.nlm.nih.gov/31681434/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,30709424,Proliferative potential and resistance to immune checkpoint blockade in lung cancer patients.,2019,10.1186/s40425-019-0506-3,https://pubmed.ncbi.nlm.nih.gov/30709424/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,33490151,Bioinformatics analysis to determine the prognostic value and prospective pathway signaling of miR-126 in non-small cell lung cancer.,2020,10.21037/atm-20-7520,https://pubmed.ncbi.nlm.nih.gov/33490151/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,30776192,The long noncoding RNA HORAS5 mediates castration-resistant prostate cancer survival by activating the androgen receptor transcriptional program.,2019,10.1002/1878-0261.12471,https://pubmed.ncbi.nlm.nih.gov/30776192/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,22096502,"KIAA0101 is overexpressed, and promotes growth and invasion in adrenal cancer.",2011,10.1371/journal.pone.0026866,https://pubmed.ncbi.nlm.nih.gov/22096502/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,15789362,Overexpressed in anaplastic thyroid carcinoma-1 (OEATC-1) as a novel gene responsible for anaplastic thyroid carcinoma.,2005,10.1002/cncr.20988,https://pubmed.ncbi.nlm.nih.gov/15789362/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
,ENSG00000259316,Neither,11313979,"p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues.",2001,10.1038/sj.onc.1204113,https://pubmed.ncbi.nlm.nih.gov/11313979/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,41009771,An Emerging Paradigm for ABCC5/MRP5 Function in Human Physiology.,2025,10.3390/ijms26189211,https://pubmed.ncbi.nlm.nih.gov/41009771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,35121660,MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function.,2022,10.1073/pnas.2111617119,https://pubmed.ncbi.nlm.nih.gov/35121660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,33771553,Deleterious Variants in ABCC12 are Detected in Idiopathic Chronic Cholestasis and Cause Intrahepatic Bile Duct Loss in Model Organisms.,2021,10.1053/j.gastro.2021.03.026,https://pubmed.ncbi.nlm.nih.gov/33771553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,40362117,Whole-Genome Sequencing Reveals the Role of Cis-Regulatory Elements and eQTL/sQTL in the Adaptive Selection of Hubei Indigenous Cattle.,2025,10.3390/ani15091301,https://pubmed.ncbi.nlm.nih.gov/40362117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,41326080,Genome-wide identification of ABC transporters and their contribution to triflumezopyrim susceptibility regulated by microRNAs in Laodelphax striatellus.,2026,10.1016/j.pestbp.2025.106791,https://pubmed.ncbi.nlm.nih.gov/41326080/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,39238930,"Prenatal opioid exposure significantly impacts placental protein kinase C (PKC) and drug transporters, leading to drug resistance and neonatal opioid withdrawal syndrome.",2024,10.3389/fnins.2024.1442915,https://pubmed.ncbi.nlm.nih.gov/39238930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,36034978,The long non-coding RNA CRNDE promotes osteosarcoma proliferation and migration by sponging miR-136-5p/MRP9 axis.,2022,10.21037/atm-22-3602,https://pubmed.ncbi.nlm.nih.gov/36034978/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,37239445,Genetic Predictors of Antipsychotic Efflux Impairment via Blood-Brain Barrier: Role of Transport Proteins.,2023,10.3390/genes14051085,https://pubmed.ncbi.nlm.nih.gov/37239445/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,42733437,Deep Neural Network Classifier for Alzheimer's Disease.,2022,10.47611/jsrhs.v11i3.3553,https://pubmed.ncbi.nlm.nih.gov/42733437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,35363194,Adenosine triphosphate-binding cassette subfamily C members in liver hepatocellular carcinoma: Bioinformatics-driven prognostic value.,2022,10.1097/md.0000000000028869,https://pubmed.ncbi.nlm.nih.gov/35363194/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,32934716,Effect of sodium butyrate on ABC transporters in lung cancer A549 and colorectal cancer HCT116 cells.,2020,10.3892/ol.2020.12011,https://pubmed.ncbi.nlm.nih.gov/32934716/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,38212294,Construction of a Lung Adenocarcinoma Prognostic Model Utilizing Serine and Glycine Metabolism-Related Genes.,2024,10.1021/acs.jproteome.3c00700,https://pubmed.ncbi.nlm.nih.gov/38212294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,38922499,"Transcriptome analysis of East Asian common octopus, Octopus sinensis, paralarvae.",2024,10.1007/s13258-024-01537-3,https://pubmed.ncbi.nlm.nih.gov/38922499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,35631534,DNA Copy Number Aberrations and Expression of ABC Transporter Genes in Breast Tumour: Correlation with the Effect of Neoadjuvant Chemotherapy and Prognosis of the Disease.,2022,10.3390/pharmaceutics14050948,https://pubmed.ncbi.nlm.nih.gov/35631534/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,35405299,Stress and the brain transcriptome: Identifying commonalities and clusters in standardized data from published experiments.,2022,10.1016/j.pnpbp.2022.110558,https://pubmed.ncbi.nlm.nih.gov/35405299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,17472575,Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm.,2007,10.1042/bj20070292,https://pubmed.ncbi.nlm.nih.gov/17472575/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,38179408,Whole genome sequencing reveals population diversity and variation in HIV-1 specific host genes.,2023,10.3389/fgene.2023.1290624,https://pubmed.ncbi.nlm.nih.gov/38179408/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,37659510,NPs-Ca promotes Cd accumulation and enhances Cd tolerance of rapeseed shoots by affecting Cd transfer and Cd fixation in pectin.,2023,10.1016/j.chemosphere.2023.140001,https://pubmed.ncbi.nlm.nih.gov/37659510/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,31289473,Effects of histone deacetylase inhibitors on ATP-binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells.,2019,10.3892/ol.2019.10319,https://pubmed.ncbi.nlm.nih.gov/31289473/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,22098952,Multidrug resistance associated proteins in multidrug resistance.,2012,10.5732/cjc.011.10329,https://pubmed.ncbi.nlm.nih.gov/22098952/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,28867665,Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.,2018,10.1016/j.pmrj.2017.08.441,https://pubmed.ncbi.nlm.nih.gov/28867665/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,28525265,Thioarsenate Toxicity and Tolerance in the Model System Arabidopsis thaliana.,2017,10.1021/acs.est.6b06028,https://pubmed.ncbi.nlm.nih.gov/28525265/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,12011458,"MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer.",2002,10.1073/pnas.102187299,https://pubmed.ncbi.nlm.nih.gov/12011458/,annotation citations | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,26441882,Role of MRP transporters in regulating antimicrobial drug inefficacy and oxidative stress-induced pathogenesis during HIV-1 and TB infections.,2015,10.3389/fmicb.2015.00948,https://pubmed.ncbi.nlm.nih.gov/26441882/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,25840885,Multidrug Resistance Proteins (MRPs) and Cancer Therapy.,2015,10.1208/s12248-015-9757-1,https://pubmed.ncbi.nlm.nih.gov/25840885/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,25437182,Proteomic profile and in silico analysis in metastatic melanoma with and without BRAF mutation.,2014,10.1371/journal.pone.0112025,https://pubmed.ncbi.nlm.nih.gov/25437182/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,22504741,Role of multidrug resistance associated proteins in drug development.,2008,10.2174/978160805292911201010003,https://pubmed.ncbi.nlm.nih.gov/22504741/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,21740521,Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases.,2011,10.1111/j.1742-4658.2011.08235.x,https://pubmed.ncbi.nlm.nih.gov/21740521/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,18220559,Multidrug resistance associated proteins as determining factors of pharmacokinetics and pharmacodynamics of drugs.,2007,10.2174/138920007782798171,https://pubmed.ncbi.nlm.nih.gov/18220559/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,16289015,The role of a novel copper complex in overcoming doxorubicin resistance in Ehrlich ascites carcinoma cells in vivo.,2006,10.1016/j.cbi.2005.10.044,https://pubmed.ncbi.nlm.nih.gov/16289015/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,17173689,Investigation of the molecular profile of basal cell carcinoma using whole genome microarrays.,2006,10.1186/1476-4598-5-74,https://pubmed.ncbi.nlm.nih.gov/17173689/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,11688999,"Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12.",2001,10.1006/bbrc.2001.5865,https://pubmed.ncbi.nlm.nih.gov/11688999/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCC12,ENSG00000140798,Neither,11483364,"Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12.",2001,10.1016/s0378-1119(01)00572-8,https://pubmed.ncbi.nlm.nih.gov/11483364/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,41964880,ACP4 Variants in Hypoplastic Amelogenesis Imperfecta.,2026,10.1007/s00223-026-01512-y,https://pubmed.ncbi.nlm.nih.gov/41964880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,42053620,Amelogenin Phosphorylation Affects Protein-Protein Interactions In Vivo.,2026,10.1007/s00223-026-01530-w,https://pubmed.ncbi.nlm.nih.gov/42053620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,41594993,"""Trigger the Mind, Target the Gold"": Development and Validation of an ACPT (Acceptance and Commitment Performance Training) for Elite Shooters.",2025,10.3390/bs16010052,https://pubmed.ncbi.nlm.nih.gov/41594993/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,42268292,Plastid acyl carrier proteins play redundant roles in seed oil accumulation with functional differentiation on the fatty acid flux.,2026,10.1007/s00299-026-03873-y,https://pubmed.ncbi.nlm.nih.gov/42268292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,42189818,A novel approach for the EEG-driven assessment of divided attention through mutual information theory: A case study at the wheel.,2026,10.1371/journal.pone.0348608,https://pubmed.ncbi.nlm.nih.gov/42189818/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,39032726,Robust Brain Correlates of Cognitive Performance in Psychosis and Its Prodrome.,2025,10.1016/j.biopsych.2024.07.012,https://pubmed.ncbi.nlm.nih.gov/39032726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,37658850,Arabidopsis ACYL CARRIER PROTEIN4 and RHOMBOID LIKE10 act independently in chloroplast phosphatidate synthesis.,2023,10.1093/plphys/kiad483,https://pubmed.ncbi.nlm.nih.gov/37658850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,36183038,Enamel defects in Acp4R110C/R110C mice and human ACP4 mutations.,2022,10.1038/s41598-022-20684-9,https://pubmed.ncbi.nlm.nih.gov/36183038/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,40773061,Reduction of Tooth Replacement Disproportionately Affects the Evolution of Enamel Matrix Proteins.,2025,10.1007/s00239-025-10258-4,https://pubmed.ncbi.nlm.nih.gov/40773061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,39599949,The Successful Treatment of Multi-Resistant Colonized Burns with Large-Area Atmospheric Cold Plasma Therapy and Dermis Substitute Matrix-A Case Report.,2024,10.3390/ebj5030025,https://pubmed.ncbi.nlm.nih.gov/39599949/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,34036831,Recessive Mutations in ACP4 Cause Amelogenesis Imperfecta.,2022,10.1177/00220345211015119,https://pubmed.ncbi.nlm.nih.gov/34036831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,42075400,Spatiotemporal Distribution of Continuous Precipitation and Its Effect on Vegetation Cover in China over the Past 30 Years.,2026,10.3390/plants15081198,https://pubmed.ncbi.nlm.nih.gov/42075400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,33552707,ACPT gene is inactivated in mammalian lineages that lack enamel or teeth.,2021,10.7717/peerj.10219,https://pubmed.ncbi.nlm.nih.gov/33552707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,41010883,"""HOPE-FIT"" in Action: A Hybrid Effectiveness-Implementation Protocol for Thriving Wellness in Aging Communities.",2025,10.3390/jcm14186679,https://pubmed.ncbi.nlm.nih.gov/41010883/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,34740039,Mitochondria-targeted Pt(IV) prodrugs conjugated with an aggregation-induced emission luminogen against breast cancer cells by dual modulation of apoptosis and autophagy inhibition.,2022,10.1016/j.jinorgbio.2021.111653,https://pubmed.ncbi.nlm.nih.gov/34740039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,35997379,Multitasking Effects on Perception and Memory in Older Adults.,2022,10.3390/vision6030048,https://pubmed.ncbi.nlm.nih.gov/35997379/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,34582071,Proteins associated with the Arabidopsis thaliana plastid rhomboid-like protein RBL10.,2021,10.1111/tpj.15514,https://pubmed.ncbi.nlm.nih.gov/34582071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,41010345,Gene-Level Shift in Response to Synthetic Nitrogen Addition Promotes &lt;i&gt;Larix olgensis&lt;/i&gt; (Ussurian Larch) Growth in a Short-Term Field Trial.,2025,10.3390/life15091403,https://pubmed.ncbi.nlm.nih.gov/41010345/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,27843125,"Recessive Mutations in ACPT, Encoding Testicular Acid Phosphatase, Cause Hypoplastic Amelogenesis Imperfecta.",2016,10.1016/j.ajhg.2016.09.018,https://pubmed.ncbi.nlm.nih.gov/27843125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,33262933,The Effects of Live-Fire Drills on Visual and Auditory Cognitive Performance among Firefighters.,2020,10.5334/aogh.2626,https://pubmed.ncbi.nlm.nih.gov/33262933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,40180433,"A pragmatic covariate-constrained cluster-randomised controlled trial of hybrid parents and health workers adaptive intervention for optimal (timely, cumulative age-appropriate) community-wide routine childhood immunisation coverage: the AGINTOPIC trial.",2025,10.1136/bmjgh-2024-017403,https://pubmed.ncbi.nlm.nih.gov/40180433/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,31533416,The Effect of Hypnotics on Sleep Quality and Cognitive Function in Patients with Brain Tumors.,2020,10.3340/jkns.2019.0057,https://pubmed.ncbi.nlm.nih.gov/31533416/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,28081304,"Comparison of an AC-taxane versus AC-free regimen and paclitaxel versus docetaxel in patients with lymph node-positive breast cancer: Final results of the National Surgical Adjuvant Study of Breast Cancer 02 trial, a randomized comparative phase 3 study.",2017,10.1002/cncr.30421,https://pubmed.ncbi.nlm.nih.gov/28081304/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,37228816,Amelogenesis imperfecta: Next-generation sequencing sheds light on Witkop's classification.,2023,10.3389/fphys.2023.1130175,https://pubmed.ncbi.nlm.nih.gov/37228816/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,24402869,"Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo.",2014,10.1007/s12640-013-9455-7,https://pubmed.ncbi.nlm.nih.gov/24402869/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,29169856,Comparing the accuracy of medication order verification between pharmacists and a tech check tech model: A prospective randomised observational study.,2018,10.1016/j.sapharm.2017.11.007,https://pubmed.ncbi.nlm.nih.gov/29169856/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,29364232,Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers.,2018,10.3791/56881,https://pubmed.ncbi.nlm.nih.gov/29364232/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,17581957,Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease.,2007,10.1523/jneurosci.0299-07.2007,https://pubmed.ncbi.nlm.nih.gov/17581957/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,20234761,"Antioxidants, cadmium-induced toxicity, serum biochemical and the histological abnormalities of the kidney and testes of the male Wistar rats.",2009,10.4314/njps.v24i2.52910,https://pubmed.ncbi.nlm.nih.gov/20234761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,11386476,Effects of methylphenidate (Ritalin) on auditory performance in children with attention and auditory processing disorders.,2000,10.1044/jslhr.4304.893,https://pubmed.ncbi.nlm.nih.gov/11386476/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,19253780,Personal amplification for school-age children with auditory processing disorders.,2008,10.3766/jaaa.19.6.3,https://pubmed.ncbi.nlm.nih.gov/19253780/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,11352146,Stimulus modality and Go/NoGo effects on P3 during parallel visual and auditory continuous performance tasks.,2001,10.1017/s0048577201991279,https://pubmed.ncbi.nlm.nih.gov/11352146/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,12734762,Current perception thresholds of patients with long-term administration of maprotiline.,2003,10.1055/s-2003-39040,https://pubmed.ncbi.nlm.nih.gov/12734762/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACP4,ENSG00000142513,Neither,11414767,Molecular cloning of a novel human acid phosphatase gene (ACPT) that is highly expressed in the testis.,2001,10.1006/geno.2001.6556,https://pubmed.ncbi.nlm.nih.gov/11414767/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM4,ENSG00000215009,Neither,41975982,"Genes Involved in Lipid, Carbohydrate, and Protein Metabolism as Candidates Affecting Beef Flavor.",2026,10.3390/ani16071003,https://pubmed.ncbi.nlm.nih.gov/41975982/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM4,ENSG00000215009,Neither,30567295,Idi1 and Hmgcs2 Are Affected by Stretch in HL-1 Atrial Myocytes.,2018,10.3390/ijms19124094,https://pubmed.ncbi.nlm.nih.gov/30567295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM4,ENSG00000215009,Neither,32404959,A novel prognostic two-gene signature for triple negative breast cancer.,2020,10.1038/s41379-020-0563-7,https://pubmed.ncbi.nlm.nih.gov/32404959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM4,ENSG00000215009,Neither,20877624,Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.,2010,10.1371/journal.pone.0012862,https://pubmed.ncbi.nlm.nih.gov/20877624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,42789056,A novel homozygous chromosomal deletion encompassing the ACTL9 gene is associated with cIVF polyspermy and male infertility.,2026,10.4103/aja202630,https://pubmed.ncbi.nlm.nih.gov/42789056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,38963606,Homozygous ACTL9 mutations cause irregular mitochondrial sheath arrangement and abnormal flagellum assembly in spermatozoa and male infertility.,2024,10.1007/s10815-024-03171-0,https://pubmed.ncbi.nlm.nih.gov/38963606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,42129325,S-PrediXcan predicted gene expression in human placenta is associated with childhood-onset asthma risk.,2026,10.1038/s41598-026-51718-1,https://pubmed.ncbi.nlm.nih.gov/42129325/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,40407971,Identification of nonfunctional CABS1 causing fertilization failure and male infertility in humans: a case report.,2025,10.1007/s10815-025-03516-3,https://pubmed.ncbi.nlm.nih.gov/40407971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,38769899,Identification of a new mutation in the ACTL9 gene in men with unexplained infertility.,2024,10.1002/mgg3.2448,https://pubmed.ncbi.nlm.nih.gov/38769899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,39411542,High rate of detected variants in male &lt;i&gt;PLCZ1&lt;/i&gt; and &lt;i&gt;ACTL7A&lt;/i&gt; genes causing failed fertilization after ICSI.,2024,10.1093/hropen/hoae057,https://pubmed.ncbi.nlm.nih.gov/39411542/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,40376536,Establishment and clinical significance of genetic factor screening method for patients with nonobstructive azoospermia based on whole exon sequencing technology.,2025,10.21037/tau-2024-676,https://pubmed.ncbi.nlm.nih.gov/40376536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,37118964,Differential Proteomic Analysis of Human Sperm: A Systematic Review to Identify Candidate Targets to Monitor Sperm Quality.,2024,10.5534/wjmh.220262,https://pubmed.ncbi.nlm.nih.gov/37118964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,33626338,Homozygous pathogenic variants in ACTL9 cause fertilization failure and male infertility in humans and mice.,2021,10.1016/j.ajhg.2021.02.004,https://pubmed.ncbi.nlm.nih.gov/33626338/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,36306217,Testis-specific serine kinase 3 is required for sperm morphogenesis and male fertility.,2023,10.1111/andr.13314,https://pubmed.ncbi.nlm.nih.gov/36306217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,40428427,Multimorbidity Through the Lens of the Eye: Pathogenic Variants for Multiple Systemic Disorders Found in an Autosomal Dominant Congenital Cataract Cohort.,2025,10.3390/genes16050604,https://pubmed.ncbi.nlm.nih.gov/40428427/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,35616329,Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice.,2022,10.1242/dev.200489,https://pubmed.ncbi.nlm.nih.gov/35616329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,36589837,Gene mutations associated with fertilization failure after in vitro fertilization/intracytoplasmic sperm injection.,2022,10.3389/fendo.2022.1086883,https://pubmed.ncbi.nlm.nih.gov/36589837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,38414365,Deletion of ACTRT1 is associated with male infertility as sperm acrosomal ultrastructural defects and fertilization failure in human.,2024,10.1093/humrep/deae031,https://pubmed.ncbi.nlm.nih.gov/38414365/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,33707600,Establishment and genomic characterization of a sporadic malignant peripheral nerve sheath tumor cell line.,2021,10.1038/s41598-021-85055-2,https://pubmed.ncbi.nlm.nih.gov/33707600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,32917775,Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity.,2020,10.2337/db20-0070,https://pubmed.ncbi.nlm.nih.gov/32917775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,36896575,The human sperm proteome-Toward a panel for male fertility testing.,2023,10.1111/andr.13431,https://pubmed.ncbi.nlm.nih.gov/36896575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,29309628,Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics.,2018,10.1093/hmg/ddx429,https://pubmed.ncbi.nlm.nih.gov/29309628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTL9,ENSG00000181786,Neither,22197932,Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.,2011,10.1038/ng.1017,https://pubmed.ncbi.nlm.nih.gov/22197932/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM30,ENSG00000134249,Neither,39201790,Comprehensive Analysis of Methylome and Transcriptome to Identify Potential Genes Regulating Porcine Testis Development.,2024,10.3390/ijms25169105,https://pubmed.ncbi.nlm.nih.gov/39201790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM30,ENSG00000134249,Neither,41026804,Meta-evolutionary exome analysis identifies novel type 2 diabetes mellitus genes in the UK Biobank and all of us.,2025,10.1371/journal.pgen.1011889,https://pubmed.ncbi.nlm.nih.gov/41026804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM30,ENSG00000134249,Neither,27333034,ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease.,2016,10.1016/j.ebiom.2016.06.002,https://pubmed.ncbi.nlm.nih.gov/27333034/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM30,ENSG00000134249,Neither,31236626,Functions of 'A disintegrin and metalloproteases (ADAMs)' in the mammalian nervous system.,2019,10.1007/s00018-019-03173-7,https://pubmed.ncbi.nlm.nih.gov/31236626/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM30,ENSG00000134249,Neither,36187339,Systematic Analysis of Tumor Microenvironment Patterns and Oxidative Stress Characteristics of Endometrial Carcinoma Mediated by 5-Methylcytosine Regulators.,2022,10.1155/2022/6431164,https://pubmed.ncbi.nlm.nih.gov/36187339/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM30,ENSG00000134249,Neither,30498427,Voxel-Based Statistical Analysis of 3D Immunostained Tissue Imaging.,2018,10.3389/fnins.2018.00754,https://pubmed.ncbi.nlm.nih.gov/30498427/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM30,ENSG00000134249,Neither,27396345,Mice are not Men: ADAM30 Findings Emphasize a Broader Look Towards Murine Alzheimer's Disease Models.,2016,10.1016/j.ebiom.2016.06.035,https://pubmed.ncbi.nlm.nih.gov/27396345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM30,ENSG00000134249,Neither,23442068,Diabetes genes identified by genome-wide association studies are regulated in mice by nutritional factors in metabolically relevant tissues and by glucose concentrations in islets.,2013,10.1186/1471-2156-14-10,https://pubmed.ncbi.nlm.nih.gov/23442068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM30,ENSG00000134249,Neither,10512762,Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression.,1999,10.1006/bbrc.1999.1322,https://pubmed.ncbi.nlm.nih.gov/10512762/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM30,ENSG00000134249,Neither,25135348,Genetic variation at glucose and insulin trait loci and response to glucose-insulin-potassium (GIK) therapy: the IMMEDIATE trial.,2015,10.1038/tpj.2014.41,https://pubmed.ncbi.nlm.nih.gov/25135348/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM30,ENSG00000134249,Neither,19862325,"PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.",2009,10.1371/journal.pone.0007643,https://pubmed.ncbi.nlm.nih.gov/19862325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADIG,ENSG00000182035,Neither,42868197,Adipogenin Is A Novel Target Gene for CCAAT/Enhancer-Binding Protein α.,2026,10.1002/jcb.70134,https://pubmed.ncbi.nlm.nih.gov/42868197/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADIG,ENSG00000182035,Neither,41196993,Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex.,2025,10.1126/science.adr9755,https://pubmed.ncbi.nlm.nih.gov/41196993/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADIG,ENSG00000182035,Neither,41983459,Vendor-specific HRP antibody conjugate differences lead to unexpected immunoassay reagent interactions.,2026,10.1080/17576180.2026.2658612,https://pubmed.ncbi.nlm.nih.gov/41983459/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADIG,ENSG00000182035,Neither,40745632,Transcriptome analysis unveils multiple reasons behind delayed and slower deposition of intramuscular fat compared to subcutaneous fat in cattle.,2025,10.1186/s12864-025-11890-6,https://pubmed.ncbi.nlm.nih.gov/40745632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADIG,ENSG00000182035,Neither,41257555,Comparative histomorphometric and transcriptomic analysis reveals potential genetic determinants of pelage variation between hairy and coarse-woolly sheep.,2025,10.1186/s12864-025-12260-y,https://pubmed.ncbi.nlm.nih.gov/41257555/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADIG,ENSG00000182035,Neither,37249025,Transcriptional regulation of adipogenin expression in liver steatosis by hepatic peroxisome proliferator-activated receptor gamma.,2023,10.1111/gtc.13052,https://pubmed.ncbi.nlm.nih.gov/37249025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADIG,ENSG00000182035,Neither,33691105,Phenotypic characterization of Adig null mice suggests roles for adipogenin in the regulation of fat mass accrual and leptin secretion.,2021,10.1016/j.celrep.2021.108810,https://pubmed.ncbi.nlm.nih.gov/33691105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADIG,ENSG00000182035,Neither,37370521,"Evaluation of the Genetic Diversity, Population Structure and Selection Signatures of Three Native Chinese Pig Populations.",2023,10.3390/ani13122010,https://pubmed.ncbi.nlm.nih.gov/37370521/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADIG,ENSG00000182035,Neither,27766294,Data on regulation of the gene for the adipocyte-enriched micropeptide Adig/Smaf1 by qPCR analysis and luciferase reporter assay.,2016,10.1016/j.dib.2016.09.034,https://pubmed.ncbi.nlm.nih.gov/27766294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADIG,ENSG00000182035,Neither,34874232,Muscle transcriptome analysis reveal candidate genes and pathways related to fat and lipid metabolism in Yunling cattle.,2023,10.1080/10495398.2021.2009846,https://pubmed.ncbi.nlm.nih.gov/34874232/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADIG,ENSG00000182035,Neither,27914980,Cloning and characterization of adipogenin and its overexpression enhances fat accumulation of bovine myosatellite cells.,2017,10.1016/j.gene.2016.11.040,https://pubmed.ncbi.nlm.nih.gov/27914980/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADIG,ENSG00000182035,Neither,25338179,"Effects of yerba maté, a plant extract formulation (""YGD"") and resveratrol in 3T3-L1 adipogenesis.",2014,10.3390/molecules191016909,https://pubmed.ncbi.nlm.nih.gov/25338179/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADIG,ENSG00000182035,Neither,26427354,"Expression, regulation and functional assessment of the 80 amino acid Small Adipocyte Factor 1 (Smaf1) protein in adipocytes.",2016,10.1016/j.abb.2015.09.019,https://pubmed.ncbi.nlm.nih.gov/26427354/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADIG,ENSG00000182035,Neither,27354644,Global Liver Gene Expression Analysis on a Murine Metabolic Syndrome Model Treated by Low-molecular-weight Lychee Fruit Polyphenol (Oligonol®).,2016,,https://pubmed.ncbi.nlm.nih.gov/27354644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADIG,ENSG00000182035,Neither,23483012,Angiotensinogen gene silencing reduces markers of lipid accumulation and inflammation in cultured adipocytes.,2013,10.3389/fendo.2013.00010,https://pubmed.ncbi.nlm.nih.gov/23483012/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADIG,ENSG00000182035,Neither,35322650,Clinical influence of digital vs analog impressions in all-on-4 implant prostheses: a randomized controlled trial.,2022,,https://pubmed.ncbi.nlm.nih.gov/35322650/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKNAD1,ENSG00000162641,Neither,41015584,Tenosynovial giant cell tumour of the nasal dorsum: a novel presentation.,2026,10.1007/s00256-025-05039-5,https://pubmed.ncbi.nlm.nih.gov/41015584/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKNAD1,ENSG00000162641,Neither,35939377,Evaluation of autoantibody signatures in pituitary adenoma patients using human proteome arrays.,2022,10.1002/prca.202100111,https://pubmed.ncbi.nlm.nih.gov/35939377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKNAD1,ENSG00000162641,Neither,34455959,Identification of WHO II/III Gliomas by 16 Prognostic-related Gene Signatures using Machine Learning Methods.,2022,10.2174/0929867328666210827103049,https://pubmed.ncbi.nlm.nih.gov/34455959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKNAD1,ENSG00000162641,Neither,26292654,CNV Analysis Associates AKNAD1 with Type-2 Diabetes in Jordan Subpopulations.,2015,10.1038/srep13391,https://pubmed.ncbi.nlm.nih.gov/26292654/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKNAD1,ENSG00000162641,Neither,34666190,Identification of a risk prediction model for clinical prognosis in HER2 positive breast cancer patients.,2021,10.1016/j.ygeno.2021.10.010,https://pubmed.ncbi.nlm.nih.gov/34666190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKNAD1,ENSG00000162641,Neither,26447881,Tumor Necrosis Factor Alpha and Insulin-Like Growth Factor 1 Induced Modifications of the Gene Expression Kinetics of Differentiating Skeletal Muscle Cells.,2015,10.1371/journal.pone.0139520,https://pubmed.ncbi.nlm.nih.gov/26447881/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,42791745,Analysis of Zona-Associated Sperm as a Potential Source of Exogenous &lt;i&gt;Y-DNA&lt;/i&gt; Interference in Sex-Typing of In Vitro-Fertilized Ovine Embryos.,2026,10.3390/ani16182888,https://pubmed.ncbi.nlm.nih.gov/42791745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,42608181,Paleoproteomics reveal the genetic characteristics of Middle Pleistocene &lt;i&gt;Homo erectus&lt;/i&gt; in East Asia.,2026,10.16288/j.yczz.26-115,https://pubmed.ncbi.nlm.nih.gov/42608181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,40759687,The genetic secrets revealed from canine fetal fluids obtained in mid-pregnancy.,2025,10.1038/s41598-025-13183-0,https://pubmed.ncbi.nlm.nih.gov/40759687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,39107380,A label-free quantification method for assessing sex from modern and ancient bovine tooth enamel.,2024,10.1038/s41598-024-68603-4,https://pubmed.ncbi.nlm.nih.gov/39107380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,39380113,"Integration of long-read sequencing, DNA methylation and gene expression reveals heterogeneity in Y chromosome segment lengths in phenotypic males with 46,XX testicular disorder/difference of sex development.",2024,10.1186/s13293-024-00654-8,https://pubmed.ncbi.nlm.nih.gov/39380113/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,36359056,XX/XY Chimerism in Internal Genitalia of a Virilized Heifer.,2022,10.3390/ani12212932,https://pubmed.ncbi.nlm.nih.gov/36359056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,41153949,Genetic Diversity and Population Structure of Sika Deer (&lt;i&gt;Cervus nippon&lt;/i&gt;) Inferred by mtDNA and Y-Chromosomal Genes.,2025,10.3390/ani15203022,https://pubmed.ncbi.nlm.nih.gov/41153949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,40319061,Advancing non-destructive sex determination on human dental enamel using Raman spectroscopy.,2025,10.1038/s41598-025-00407-6,https://pubmed.ncbi.nlm.nih.gov/40319061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,35164824,"Identification of an SRY-negative 46,XX infertility male with a heterozygous deletion downstream of SOX3 gene.",2022,10.1186/s13039-022-00580-7,https://pubmed.ncbi.nlm.nih.gov/35164824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,40768595,Sex Identification and Species Confirmation in Modern and Archeological Caprine Enamel.,2025,10.1021/acs.jproteome.5c00012,https://pubmed.ncbi.nlm.nih.gov/40768595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,37953951,Antibody-based sex determination of human skeletal remains.,2023,10.1016/j.isci.2023.108191,https://pubmed.ncbi.nlm.nih.gov/37953951/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,37370034,Characterization of loss of chromosome Y in peripheral blood cells in male Han Chinese patients with schizophrenia.,2023,10.1186/s12888-023-04929-z,https://pubmed.ncbi.nlm.nih.gov/37370034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,32273824,Copy-number analysis of Y-linked loci in young men with non-obstructive azoospermia: Implications for the rarity of early onset mosaic loss of chromosome Y.,2020,10.1002/rmb2.12321,https://pubmed.ncbi.nlm.nih.gov/32273824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,36932691,Mosaic loss of Y chromosome in monocytes is associated with lower survival after transcatheter aortic valve replacement.,2023,10.1093/eurheartj/ehad093,https://pubmed.ncbi.nlm.nih.gov/36932691/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,33903958,Molecular characterization of the Yp11.2 region deletion in the Chinese Han population.,2021,10.1007/s00414-021-02596-x,https://pubmed.ncbi.nlm.nih.gov/33903958/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,39902298,Tell me y: anticipation of sex discrepancies in cell-free DNA testing due to maternal genetic abnormalities: a case report.,2024,10.3389/fgene.2024.1502287,https://pubmed.ncbi.nlm.nih.gov/39902298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,31511583,Enamel peptides reveal the sex of the Late Antique 'Lovers of Modena'.,2019,10.1038/s41598-019-49562-7,https://pubmed.ncbi.nlm.nih.gov/31511583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,31572820,"Amorphus Globosus Foetuses in Polish Holstein Cattle: Anatomical, Histological, and Genetic Studies.",2019,10.2478/jvetres-2019-0057,https://pubmed.ncbi.nlm.nih.gov/31572820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,30994363,Analysis of the Yp11.2 Deletion Region of Phenotypically Normal Males with an AMELY-Null Allele in the Chinese Han Population.,2019,10.1089/gtmb.2018.0231,https://pubmed.ncbi.nlm.nih.gov/30994363/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,31754761,"The Evolution of Unusually Small Amelogenin Genes in Cetaceans; Pseudogenization, X-Y Gene Conversion, and Feeding Strategy.",2020,10.1007/s00239-019-09917-0,https://pubmed.ncbi.nlm.nih.gov/31754761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,33611263,Corona vaccine review,2021,10.1556/650.2021.32172,https://pubmed.ncbi.nlm.nih.gov/33611263/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,31720096,"A pilot study-genetic diversity and population structure of snow leopards of Gilgit-Baltistan, Pakistan, using molecular techniques.",2019,10.7717/peerj.7672,https://pubmed.ncbi.nlm.nih.gov/31720096/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMELY,ENSG00000099721,Neither,34120100,Supplementary valproate therapy for glioma patients: An alternative opportunity to enhance the efficiency of radio-chemotherapy,2021,10.1556/650.2021.32110,https://pubmed.ncbi.nlm.nih.gov/34120100/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANHX,ENSG00000227059,Neither,39849206,Rapid human oogonia-like cell specification via transcription factor-directed differentiation.,2025,10.1038/s44319-025-00371-2,https://pubmed.ncbi.nlm.nih.gov/39849206/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANHX,ENSG00000227059,Neither,35669784,ZNF384: A Potential Therapeutic Target for Psoriasis and Alzheimer's Disease Through Inflammation and Metabolism.,2022,10.3389/fimmu.2022.892368,https://pubmed.ncbi.nlm.nih.gov/35669784/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANHX,ENSG00000227059,Neither,31104065,Use of Genome-Scale Integrated Analysis to Identify Key Genes and Potential Molecular Mechanisms in Recurrence of Lower-Grade Brain Glioma.,2019,10.12659/msm.913602,https://pubmed.ncbi.nlm.nih.gov/31104065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD60,ENSG00000124227,Neither,33853519,A QTL for conformation of back and croup influences lateral gait quality in Icelandic horses.,2021,10.1186/s12864-021-07454-z,https://pubmed.ncbi.nlm.nih.gov/33853519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD60,ENSG00000124227,Neither,26369327,Genome-wide association study for female fertility in Nordic Red cattle.,2015,10.1186/s12863-015-0269-x,https://pubmed.ncbi.nlm.nih.gov/26369327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANTXRL,ENSG00000274209,Neither,34341728,Tumor elastography and its association with cell-free tumor DNA in the plasma of breast tumor patients: a pilot study.,2021,10.21037/qims-20-443,https://pubmed.ncbi.nlm.nih.gov/34341728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANTXRL,ENSG00000274209,Neither,33857910,Screening and validation of candidate genes involved in the regulation of egg yolk deposition in chicken.,2021,10.1016/j.psj.2021.101077,https://pubmed.ncbi.nlm.nih.gov/33857910/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANTXRL,ENSG00000274209,Neither,26136833,Assessment of copy number variations in the brain genome of schizophrenia patients.,2015,10.1186/s13039-015-0144-5,https://pubmed.ncbi.nlm.nih.gov/26136833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARGFX,ENSG00000186103,Neither,39809281,Allelic transcriptomic profiling identifies the role of PRD-like homeobox genes in human embryonic-cleavage-stage arrest.,2025,10.1016/j.devcel.2024.12.031,https://pubmed.ncbi.nlm.nih.gov/39809281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARGFX,ENSG00000186103,Neither,40328227,Human-specific contributors to cleavage-stage embryonic arrest during maternal to zygotic transition.,2025,10.1016/j.devcel.2025.04.007,https://pubmed.ncbi.nlm.nih.gov/40328227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARGFX,ENSG00000186103,Neither,40718712,Activation of telomerase via madecassic acid enhances the developmental competence of the SCNT-derived bovine embryos.,2025,10.3389/fcell.2025.1628953,https://pubmed.ncbi.nlm.nih.gov/40718712/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARGFX,ENSG00000186103,Neither,35512670,"PRD-Class Homeobox Genes in Bovine Early Embryos: Function, Evolution, and Overlapping Roles.",2022,10.1093/molbev/msac098,https://pubmed.ncbi.nlm.nih.gov/35512670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARGFX,ENSG00000186103,Neither,39325344,Unraveling the mysteries of early embryonic arrest: genetic factors and molecular mechanisms.,2024,10.1007/s10815-024-03259-7,https://pubmed.ncbi.nlm.nih.gov/39325344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARGFX,ENSG00000186103,Neither,39506635,Molecular cloning of PRD-like homeobox genes expressed in bovine oocytes and early IVF embryos.,2024,10.1186/s12864-024-10969-w,https://pubmed.ncbi.nlm.nih.gov/39506635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARGFX,ENSG00000186103,Neither,37454491,Transcriptome analysis of primary sporadic neuroendocrine tumours of the intestine identified three different molecular subgroups.,2023,10.1016/j.prp.2023.154674,https://pubmed.ncbi.nlm.nih.gov/37454491/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARGFX,ENSG00000186103,Neither,29423137,Mouse Obox and Crxos modulate preimplantation transcriptional profiles revealing similarity between paralogous mouse and human homeobox genes.,2018,10.1186/s13227-018-0091-4,https://pubmed.ncbi.nlm.nih.gov/29423137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARGFX,ENSG00000186103,Neither,27412763,Characterization and target genes of nine human PRD-like homeobox domain genes expressed exclusively in early embryos.,2016,10.1038/srep28995,https://pubmed.ncbi.nlm.nih.gov/27412763/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARGFX,ENSG00000186103,Neither,20565723,The origin and evolution of ARGFX homeobox loci in mammalian radiation.,2010,10.1186/1471-2148-10-182,https://pubmed.ncbi.nlm.nih.gov/20565723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARGFX,ENSG00000186103,Neither,26360614,Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development.,2015,10.1038/ncomms9207,https://pubmed.ncbi.nlm.nih.gov/26360614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARGFX,ENSG00000186103,Neither,27296695,Evolutionary origin and functional divergence of totipotent cell homeobox genes in eutherian mammals.,2016,10.1186/s12915-016-0267-0,https://pubmed.ncbi.nlm.nih.gov/27296695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARGFX,ENSG00000186103,Neither,21509852,Analysis of the gene expression pattern of bovine blastocysts at three stages of development.,2011,10.1002/mrd.21286,https://pubmed.ncbi.nlm.nih.gov/21509852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARGFX,ENSG00000186103,Neither,21679462,The dynamics of vertebrate homeobox gene evolution: gain and loss of genes in mouse and human lineages.,2011,10.1186/1471-2148-11-169,https://pubmed.ncbi.nlm.nih.gov/21679462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARGFX,ENSG00000186103,Neither,17005330,"Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line.",2007,10.1016/j.gene.2006.07.034,https://pubmed.ncbi.nlm.nih.gov/17005330/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL13A,ENSG00000174225,Neither,30009987,Developmental expression of the zebrafish Arf-like small GTPase paralogs arl13a and arl13b.,2018,10.1016/j.gep.2018.07.002,https://pubmed.ncbi.nlm.nih.gov/30009987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL14EPL,ENSG00000268223,Neither,31440059,Identification of seven-gene signature for prediction of lung squamous cell carcinoma.,2019,10.2147/ott.s198998,https://pubmed.ncbi.nlm.nih.gov/31440059/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMH2,ENSG00000260286,Neither,41271765,ARMH2 is a cytosolic component of CatSper crucial for sperm function.,2025,10.1038/s41467-025-65952-0,https://pubmed.ncbi.nlm.nih.gov/41271765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMH2,ENSG00000260286,Neither,42695107,Genome-wide cis-expression Quantitative Trait Loci (eQTL) and transcriptomic signals reveal distinct molecular regulation across correlated feed efficiency traits.,2026,10.3389/fgene.2026.1871055,https://pubmed.ncbi.nlm.nih.gov/42695107/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATXN3L,ENSG00000123594,Neither,41818480,Retrotransposition Events Shape the Evolution of the Ataxin-3 Gene Family in Primates.,2026,10.1093/gbe/evag047,https://pubmed.ncbi.nlm.nih.gov/41818480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATXN3L,ENSG00000123594,Neither,40721863,Gene editing for Spinocerebellar ataxia type 3 taking advantage of the human ATXN3L paralog as replacement gene.,2025,10.1038/s41434-025-00557-2,https://pubmed.ncbi.nlm.nih.gov/40721863/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATXN3L,ENSG00000123594,Neither,37845370,Functional implications of paralog genes in polyglutamine spinocerebellar ataxias.,2023,10.1007/s00439-023-02607-4,https://pubmed.ncbi.nlm.nih.gov/37845370/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATXN3L,ENSG00000123594,Neither,38730027,Diagnostic implications of ubiquitination-related gene signatures in Alzheimer's disease.,2024,10.1038/s41598-024-61363-1,https://pubmed.ncbi.nlm.nih.gov/38730027/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATXN3L,ENSG00000123594,Neither,37008788,The Josephin domain (JD) containing proteins are predicted to bind to the same interactors: Implications for spinocerebellar ataxia type 3 (SCA3) studies using Drosophila melanogaster mutants.,2023,10.3389/fnmol.2023.1140719,https://pubmed.ncbi.nlm.nih.gov/37008788/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATXN3L,ENSG00000123594,Neither,26079537,"Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5).",2015,10.18632/oncotarget.4128,https://pubmed.ncbi.nlm.nih.gov/26079537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATXN3L,ENSG00000123594,Neither,32143396,Differential Expression of DUB Genes in Ovarian Cells Treated with Di-2-Ethylhexyl Phthalate.,2020,10.3390/ijms21051755,https://pubmed.ncbi.nlm.nih.gov/32143396/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATXN3L,ENSG00000123594,Neither,26648445,Distinct X-chromosome SNVs from some sporadic AD samples.,2015,10.1038/srep18012,https://pubmed.ncbi.nlm.nih.gov/26648445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATXN3L,ENSG00000123594,Neither,29545200,Alterations in Placental Gene Expression of Pregnant Women with Chronic Chagas Disease.,2018,10.1016/j.ajpath.2018.02.011,https://pubmed.ncbi.nlm.nih.gov/29545200/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATXN3L,ENSG00000123594,Neither,21118805,Crystal structure of a Josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activity.,2011,10.1074/jbc.m110.177360,https://pubmed.ncbi.nlm.nih.gov/21118805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATXN3L,ENSG00000123594,Neither,24292675,The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells.,2014,10.1038/onc.2013.512,https://pubmed.ncbi.nlm.nih.gov/24292675/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATXN3L,ENSG00000123594,Neither,19699092,Deubiquitinase activities required for hepatocyte growth factor-induced scattering of epithelial cells.,2009,10.1016/j.cub.2009.07.040,https://pubmed.ncbi.nlm.nih.gov/19699092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATXN3L,ENSG00000123594,Neither,11450850,"The genomic structure and expression of MJD, the Machado-Joseph disease gene.",2001,10.1007/s100380170060,https://pubmed.ncbi.nlm.nih.gov/11450850/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,38363811,Defining morphologically and genetically distinct GABAergic/cholinergic amacrine cell subtypes in the vertebrate retina.,2024,10.1371/journal.pbio.3002506,https://pubmed.ncbi.nlm.nih.gov/38363811/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,37799623,Uncovering the Achilles heel of genetic heterogeneity: machine learning-based classification and immunological properties of necroptosis clusters in Alzheimer's disease.,2023,10.3389/fnagi.2023.1249682,https://pubmed.ncbi.nlm.nih.gov/37799623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,38034500,Hypoxia endothelial cells-derived exosomes facilitate diabetic wound healing through improving endothelial cell function and promoting M2 macrophages polarization.,2024,10.1016/j.bioactmat.2023.10.020,https://pubmed.ncbi.nlm.nih.gov/38034500/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,32937137,LIM-Homeodomain Transcription Factor LHX4 Is Required for the Differentiation of Retinal Rod Bipolar Cells and OFF-Cone Bipolar Subtypes.,2020,10.1016/j.celrep.2020.108144,https://pubmed.ncbi.nlm.nih.gov/32937137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,34306008,Evolutionary Perspective and Expression Analysis of Intronless Genes Highlight the Conservation of Their Regulatory Role.,2021,10.3389/fgene.2021.654256,https://pubmed.ncbi.nlm.nih.gov/34306008/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,29615777,A comparative analysis of rod bipolar cell transcriptomes identifies novel genes implicated in night vision.,2018,10.1038/s41598-018-23901-6,https://pubmed.ncbi.nlm.nih.gov/29615777/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,21858141,AP-2δ is a crucial transcriptional regulator of the posterior midbrain.,2011,10.1371/journal.pone.0023483,https://pubmed.ncbi.nlm.nih.gov/21858141/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,24572572,Histone demethylase Jmjd3 is required for the development of subsets of retinal bipolar cells.,2014,10.1073/pnas.1311480111,https://pubmed.ncbi.nlm.nih.gov/24572572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,25556712,Roles of histone H3K27 trimethylase Ezh2 in retinal proliferation and differentiation.,2015,10.1002/dneu.22261,https://pubmed.ncbi.nlm.nih.gov/25556712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,15363390,The transcription factor Bhlhb4 is required for rod bipolar cell maturation.,2004,10.1016/j.neuron.2004.08.032,https://pubmed.ncbi.nlm.nih.gov/15363390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,18260140,Identification of molecular markers of bipolar cells in the murine retina.,2008,10.1002/cne.21639,https://pubmed.ncbi.nlm.nih.gov/18260140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,26427469,Regulation of Retinal Development via the Epigenetic Modification of Histone H3.,2016,10.1007/978-3-319-17121-0_84,https://pubmed.ncbi.nlm.nih.gov/26427469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,11863370,BHLHB4 is a bHLH transcriptional regulator in pancreas and brain that marks the dimesencephalic boundary.,2002,10.1006/geno.2002.6708,https://pubmed.ncbi.nlm.nih.gov/11863370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,21503155,Comparison of Pretectal Genoarchitectonic Pattern between Quail and Chicken Embryos.,2011,10.3389/fnana.2011.00023,https://pubmed.ncbi.nlm.nih.gov/21503155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,19790262,Genoarchitectonic profile of developing nuclear groups in the chicken pretectum.,2009,10.1002/cne.22115,https://pubmed.ncbi.nlm.nih.gov/19790262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,19435948,"Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers.",2009,10.1093/carcin/bgp114,https://pubmed.ncbi.nlm.nih.gov/19435948/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,18003851,Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells.,2007,10.1523/jneurosci.3951-07.2007,https://pubmed.ncbi.nlm.nih.gov/18003851/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,20018684,Direct rod input to cone BCs and direct cone input to rod BCs challenge the traditional view of mammalian BC circuitry.,2010,10.1073/pnas.0907178107,https://pubmed.ncbi.nlm.nih.gov/20018684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,21655357,Genetic networks in the mouse retina: growth associated protein 43 and phosphatase tensin homolog network.,2011,,https://pubmed.ncbi.nlm.nih.gov/21655357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BHLHE23,ENSG00000125533,Neither,19587322,Genetic dissection of rod and cone pathways in the dark-adapted mouse retina.,2009,10.1152/jn.00142.2009,https://pubmed.ncbi.nlm.nih.gov/19587322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,40613036,BLID is a drug-responsive target of FOXO3a and multi-omics analysis reveals survival mechanisms and therapeutic vulnerabilities in BLID-deficient breast cancer cells.,2025,10.3892/ol.2025.15155,https://pubmed.ncbi.nlm.nih.gov/40613036/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,37160927,RNU12 inhibits gastric cancer progression via sponging miR-575 and targeting BLID.,2023,10.1038/s41598-023-34539-4,https://pubmed.ncbi.nlm.nih.gov/37160927/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,26629946,BLID: A Novel Tumor-Suppressor Gene.,2014,10.3727/096504015x14410238486568,https://pubmed.ncbi.nlm.nih.gov/26629946/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,30195794,A Novel Mechanism of Doxorubicin Resistance and Tumorigenesis Mediated by MicroRNA-501-5p-Suppressed BLID.,2018,10.1016/j.omtn.2018.06.011,https://pubmed.ncbi.nlm.nih.gov/30195794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,23928696,BRCC2 inhibits breast cancer cell growth and metastasis in vitro and in vivo via downregulating AKT pathway.,2013,10.1038/cddis.2013.290,https://pubmed.ncbi.nlm.nih.gov/23928696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,27035098,MicroRNA-603 functions as an oncogene by suppressing BRCC2 protein translation in osteosarcoma.,2016,10.3892/or.2016.4718,https://pubmed.ncbi.nlm.nih.gov/27035098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,32730261,Genetic and environmental factors related to the development of myopic maculopathy in Spanish patients.,2020,10.1371/journal.pone.0236071,https://pubmed.ncbi.nlm.nih.gov/32730261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,24532431,Aberrant BLID expression is associated with breast cancer progression.,2014,10.1007/s13277-014-1710-x,https://pubmed.ncbi.nlm.nih.gov/24532431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,21846966,Frequent loss of the BLID gene in early-onset breast cancer.,2011,10.1159/000330265,https://pubmed.ncbi.nlm.nih.gov/21846966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,25728273,MicroRNA-575 targets BLID to promote growth and invasion of non-small cell lung cancer cells.,2015,10.1016/j.febslet.2015.02.013,https://pubmed.ncbi.nlm.nih.gov/25728273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,26750490,miR-17-5p promotes the growth of osteosarcoma in a BRCC2-dependent mechanism.,2016,10.3892/or.2016.4542,https://pubmed.ncbi.nlm.nih.gov/26750490/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,20400521,The proapoptotic molecule BLID interacts with Bcl-XL and its downregulation in breast cancer correlates with poor disease-free and overall survival.,2010,10.1158/1078-0432.ccr-09-2351,https://pubmed.ncbi.nlm.nih.gov/20400521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,18940476,Assignment of the BLID gene to 11q24.1 by fluorescence in situ hybridization.,2008,10.1016/j.cancergencyto.2008.06.011,https://pubmed.ncbi.nlm.nih.gov/18940476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,21031016,Evaluation of BLID and LOC399959 as candidate genes for high myopia in the Chinese Han population.,2010,,https://pubmed.ncbi.nlm.nih.gov/21031016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,29518473,Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells.,2018,10.1016/j.toxlet.2018.03.003,https://pubmed.ncbi.nlm.nih.gov/29518473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,19779542,A genome-wide association analysis identified a novel susceptible locus for pathological myopia at 11q24.1.,2009,10.1371/journal.pgen.1000660,https://pubmed.ncbi.nlm.nih.gov/19779542/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,15069058,"BRCC2, a novel BH3-like domain-containing protein, induces apoptosis in a caspase-dependent manner.",2004,10.1074/jbc.m400159200,https://pubmed.ncbi.nlm.nih.gov/15069058/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,24186737,Two components of onset and recovery during photoinhibition of Ulva rotundata.,1992,10.1007/bf00195321,https://pubmed.ncbi.nlm.nih.gov/24186737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,24194075,Photoacclimation and photoinhibition in Ulva rotundata as influenced by nitrogen availability.,1991,10.1007/bf00197952,https://pubmed.ncbi.nlm.nih.gov/24194075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLID,ENSG00000259571,Neither,34153640,Geographically weighted poisson regression under linear model of coregionalization assistance: Application to a bicycle crash study.,2021,10.1016/j.aap.2021.106230,https://pubmed.ncbi.nlm.nih.gov/34153640/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,42327343,&lt;i&gt;CDHR2&lt;/i&gt; c.2233C &gt; T Is Involved in Human Familial Ovarian Immature Teratoma With &lt;i&gt;BMP15&lt;/i&gt; c.262C &gt; T.,2026,10.1155/humu/8441244,https://pubmed.ncbi.nlm.nih.gov/42327343/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,42235440,"Genome-wide characterization of the TGF-β superfamily identifies bmp15, gdf9, and gsdf as sex-biased candidate regulators of gonadal differentiation in the synchronous hermaphrodite Plectropomus leopardus.",2026,10.1016/j.cbd.2026.101892,https://pubmed.ncbi.nlm.nih.gov/42235440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,42664615,Global downstream BMP15 pathway analysis in human ovarian granulosa cells reveals novel genetic variations associated with primary ovarian insufficiency.,2026,10.1016/j.maturitas.2026.109093,https://pubmed.ncbi.nlm.nih.gov/42664615/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,42265580,Differential expression of Musashi 2 in single and double corpus luteum of hybrid Mongolian sheep.,2026,10.1186/s12864-026-12981-8,https://pubmed.ncbi.nlm.nih.gov/42265580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,41998717,BMP15 regulates proliferation of sheep granulosa cells with different genotypes via the TGF-β/SMAD signaling pathway.,2026,10.1186/s13048-026-02106-w,https://pubmed.ncbi.nlm.nih.gov/41998717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,42046697,Cryoprotectant-dependent preservation of cellular viability and oocyte-secreted factors in slow-frozen feline ovarian tissue.,2026,10.14202/vetworld.2026.1119-1131,https://pubmed.ncbi.nlm.nih.gov/42046697/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,42108981,Mutation analysis of the &lt;i&gt;FOXL2&lt;/i&gt; and &lt;i&gt;BMP15&lt;/i&gt; genes in patients with premature ovarian insufficiency.,2026,10.4274/tjod.galenos.2026.68957,https://pubmed.ncbi.nlm.nih.gov/42108981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,41589036,Co-administration of Bone Marrow-derived Mesenchymal Stem Cells and Royal Jelly Improved Ovarian Tissue Function in PCOS Rats via the Regulation of Inflammation and Angiogenesis.,2026,10.22074/ijfs.2025.2050243.1806,https://pubmed.ncbi.nlm.nih.gov/41589036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,42483667,Ovarian function and X chromosome tissue mosaicism in adolescents with Turner syndrome and ongoing spontaneous puberty.,2026,10.3389/fendo.2026.1866671,https://pubmed.ncbi.nlm.nih.gov/42483667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,41673609,AMH specifically targets neuronal AMHR2 to modulate the progression of polycystic ovary syndrome.,2026,10.1186/s12902-025-02130-9,https://pubmed.ncbi.nlm.nih.gov/41673609/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,42665132,Endocrine disrupting effects of estrone on male Siniperca chuatsi: From gonadal remodeling to gene regulation.,2027,10.1016/j.jsbmb.2026.107107,https://pubmed.ncbi.nlm.nih.gov/42665132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,42008046,Gonadal Transcriptomic Atlas Reveals Conserved and Sex-Biased Regulatory Networks in Black-Spotted Croaker (Protonibea diacanthus).,2026,10.1007/s10126-026-10613-6,https://pubmed.ncbi.nlm.nih.gov/42008046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,41249776,"Effects of 17α-Ethinylestradiol on Development and Gonadal Differentiation in the Estuarine Mummichog, Fundulus heteroclitus.",2026,10.1002/jez.70045,https://pubmed.ncbi.nlm.nih.gov/41249776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,41514836,"Comparative RNA-Seq Analysis of Differentially Expressed Genes in the Testis and Ovary of Mudskipper, &lt;i&gt;Boleophthalmus pectinirostris&lt;/i&gt;.",2026,10.3390/ani16010150,https://pubmed.ncbi.nlm.nih.gov/41514836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,40615883,"The effect of aqueous Stevia rebaudiana extract and clomiphene citrate on the expression of GDF9, PTEN, BMP15 genes, and antioxidant levels in a letrozole-induced polycystic ovary syndrome model in Wistar rats.",2025,10.1186/s13048-025-01719-x,https://pubmed.ncbi.nlm.nih.gov/40615883/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,40492505,RSPO2 Coordinates with GDF9:BMP15 Heterodimers to Promote Granulosa Cell and Oocyte Development in Mice.,2025,10.1002/advs.202501973,https://pubmed.ncbi.nlm.nih.gov/40492505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,37992158,Macrophage activation drives ovarian failure and masculinization in zebrafish.,2023,10.1126/sciadv.adg7488,https://pubmed.ncbi.nlm.nih.gov/37992158/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,40289073,Roles of GDF9 and BMP15 in equine follicular development: in vivo content and in vitro effects of IGF1 and cortisol on granulosa cells.,2025,10.1186/s12917-025-04744-6,https://pubmed.ncbi.nlm.nih.gov/40289073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,42483683,Regulation of ovarian function in domestic animals: translational insights into human ovarian dynamics and dysfunction.,2026,10.3389/fendo.2026.1863960,https://pubmed.ncbi.nlm.nih.gov/42483683/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,42281922,&lt;i&gt;COL1A1&lt;/i&gt; regulates the proliferative function of goat ovarian granulosa cells via PI3K/AKT/mTOR pathway.,2026,10.1016/j.vas.2026.100708,https://pubmed.ncbi.nlm.nih.gov/42281922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,41202450,FSHR-GnRH bispecific vaccine suppresses the fertility of female rats.,2026,10.1016/j.theriogenology.2025.117742,https://pubmed.ncbi.nlm.nih.gov/41202450/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,42289696,"Stage-, dose- and course-dependent disruption of mice fetal ovarian development following prenatal dexamethasone exposure.",2026,10.1186/s13048-026-02158-y,https://pubmed.ncbi.nlm.nih.gov/42289696/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,41115340,Bisphenol S as an emerging osteotoxicant: Mechanistic insights from osteoblasts and zebrafish models.,2025,10.1016/j.ecoenv.2025.119240,https://pubmed.ncbi.nlm.nih.gov/41115340/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,40472697,Dibutyl phthalate promotes central precocious puberty through primordial follicle activation by downregulating BMP15.,2025,10.1016/j.ecoenv.2025.118460,https://pubmed.ncbi.nlm.nih.gov/40472697/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,42270041,Adiponectin preserves follicles through ADIPOR1/ADIPOR2-driven fatty acid metabolism.,2026,10.1016/j.molmet.2026.102392,https://pubmed.ncbi.nlm.nih.gov/42270041/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,39922201,Impact of female age on concentrations of reproductive hormones and oocyte-specific growth factors in follicular fluid from human small antral follicles.,2025,10.1093/humrep/deaf017,https://pubmed.ncbi.nlm.nih.gov/39922201/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,40696273,"The impact of prenatal amoxicillin exposure at different doses, stages, and courses on offspring ovarian development.",2025,10.1186/s10020-025-01322-2,https://pubmed.ncbi.nlm.nih.gov/40696273/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,40969411,Thymoquinone alleviates the adverse effects of cyclophosphamide on oogenesis and in vitro fertilization (IVF) in NMRI mice.,2025,10.22038/ajp.2025.25734,https://pubmed.ncbi.nlm.nih.gov/40969411/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,42883097,"Balancing Prolificacy and Lamb Meat Production: Links Among Litter Size, Prenatal Development, Carcass Traits, and Meat Quality in Sheep.",2026,10.3390/ani16193128,https://pubmed.ncbi.nlm.nih.gov/42883097/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,42250527,Effects of dietary supplementation with pumpkin powder on egg quality and antioxidant function in laying hens.,2026,10.1016/j.psj.2026.107204,https://pubmed.ncbi.nlm.nih.gov/42250527/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,40851921,"Therapeutic Effects of Photobiomodulation Therapy on Ovarian Structure and GDF9, BMP15 and BMP4 Expression in the Spinal Cord Injury Female Rat Model.",2025,10.34172/jlms.2025.12,https://pubmed.ncbi.nlm.nih.gov/40851921/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,38074942,Impact of GnRH agonist and GnRH antagonist on GDF9 and BMP15 expression in mouse ovaries and oocyte development.,2023,10.1590/1984-3143-ar2023-0040,https://pubmed.ncbi.nlm.nih.gov/38074942/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,39018835,Exogenous FSH/LH modulates TGF beta signaling genes in granulosa cells of Simmental heifers without affecting IVP results.,2024,10.1016/j.theriogenology.2024.07.010,https://pubmed.ncbi.nlm.nih.gov/39018835/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,41463853,"Sodium Butyrate Promotes In Vitro Development of Mouse Preantral Follicles and Improves Oocyte Quality by Regulating Steroidogenesis, Oxidative Stress, and Cytoskeleton Remodeling.",2025,10.3390/ani15243567,https://pubmed.ncbi.nlm.nih.gov/41463853/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,38999305,Current Status of Ovarian and Endometrial Biomarkers in Predicting ART Outcomes.,2024,10.3390/jcm13133739,https://pubmed.ncbi.nlm.nih.gov/38999305/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,36689045,Decreased GDF9 and BMP15 in follicle fluid and granulosa cells and outcomes of IVF-ET among young patients with low prognosis.,2023,10.1007/s10815-023-02723-0,https://pubmed.ncbi.nlm.nih.gov/36689045/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BMP15,ENSG00000130385,Neither,39022075,"A novel signature of seven aging-related genes for risk stratification, prognosis prediction and benefit evaluation of chemotherapy, and immunotherapy in elderly patients with lung adenocarcinoma.",2024,10.1016/j.heliyon.2024.e33268,https://pubmed.ncbi.nlm.nih.gov/39022075/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFB3,ENSG00000186190,Neither,41321507,Regulatory effects of hawthorn leaf flavonoids and stevioside on the uterine function and eggshell quality in laying hens.,2025,10.1016/j.aninu.2025.06.007,https://pubmed.ncbi.nlm.nih.gov/41321507/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFB3,ENSG00000186190,Neither,39728450,Transcriptomic Profiling Reveals Altered Expression of Genes Involved in Metabolic and Immune Processes in NDV-Infected Chicken Embryos.,2024,10.3390/metabo14120669,https://pubmed.ncbi.nlm.nih.gov/39728450/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFB3,ENSG00000186190,Neither,39394962,Reticulophagy and viral infection.,2025,10.1080/15548627.2024.2414424,https://pubmed.ncbi.nlm.nih.gov/39394962/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFB3,ENSG00000186190,Neither,33277377,BPIFB3 interacts with ARFGAP1 and TMED9 to regulate non-canonical autophagy and RNA virus infection.,2021,10.1242/jcs.251835,https://pubmed.ncbi.nlm.nih.gov/33277377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFB3,ENSG00000186190,Neither,35712705,Age-Related Increase of Collagen/Fibrin Deposition and High PAI-1 Production in Human Nasal Polyps.,2022,10.3389/fphar.2022.845324,https://pubmed.ncbi.nlm.nih.gov/35712705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFB3,ENSG00000186190,Neither,32102874,BPIFB3 Regulates Endoplasmic Reticulum Morphology To Facilitate Flavivirus Replication.,2020,10.1128/jvi.00029-20,https://pubmed.ncbi.nlm.nih.gov/32102874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFB3,ENSG00000186190,Neither,33535430,"Effects of Essential Oils-Based Supplement and Salmonella Infection on Gene Expression, Blood Parameters, Cecal Microbiome, and Egg Production in Laying Hens.",2021,10.3390/ani11020360,https://pubmed.ncbi.nlm.nih.gov/33535430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFB3,ENSG00000186190,Neither,32718314,Transcriptome analysis of the uterus of hens laying eggs differing in cuticle deposition.,2020,10.1186/s12864-020-06882-7,https://pubmed.ncbi.nlm.nih.gov/32718314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFB3,ENSG00000186190,Neither,25491355,BPIFB3 regulates autophagy and coxsackievirus B replication through a noncanonical pathway independent of the core initiation machinery.,2014,10.1128/mbio.02147-14,https://pubmed.ncbi.nlm.nih.gov/25491355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFB3,ENSG00000186190,Neither,31316551,Genomic Analysis Reveals Pleiotropic Alleles at EDN3 and BMP7 Involved in Chicken Comb Color and Egg Production.,2019,10.3389/fgene.2019.00612,https://pubmed.ncbi.nlm.nih.gov/31316551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFB3,ENSG00000186190,Neither,26962226,BPIFB6 Regulates Secretory Pathway Trafficking and Enterovirus Replication.,2016,10.1128/jvi.00170-16,https://pubmed.ncbi.nlm.nih.gov/26962226/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFB3,ENSG00000186190,Neither,11971875,PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx.,2002,10.1093/hmg/11.8.937,https://pubmed.ncbi.nlm.nih.gov/11971875/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,37967251,Transcript Isoform Diversity of Ampliconic Genes on the Y Chromosome of Great Apes.,2023,10.1093/gbe/evad205,https://pubmed.ncbi.nlm.nih.gov/37967251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,41034841,Bronchoalveolar lavage proteomics in exacerbation of bronchiectasis.,2025,10.1186/s12890-025-03904-6,https://pubmed.ncbi.nlm.nih.gov/41034841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,38444014,Cytogenetics investigation in 151 Brazilian infertile male patients and genomic analysis in selected cases: experience of 14 years in a public genetic service.,2024,10.1186/s13104-024-06710-1,https://pubmed.ncbi.nlm.nih.gov/38444014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,39358566,Comprehensive analysis of chromosomal breakpoints and candidate genes associated with male infertility: insights from cytogenetic studies and expression analyses.,2024,10.1007/s00335-024-10074-z,https://pubmed.ncbi.nlm.nih.gov/39358566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,38796713,Elucidating the impact of Y chromosome microdeletions and altered gene expression on male fertility in assisted reproduction.,2024,10.1093/hmg/ddae086,https://pubmed.ncbi.nlm.nih.gov/38796713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,25799347,De novo origin of VCY2 from autosome to Y-transposed amplicon.,2015,10.1371/journal.pone.0119651,https://pubmed.ncbi.nlm.nih.gov/25799347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,33781384,A common 1.6 mb Y-chromosomal inversion predisposes to subsequent deletions and severe spermatogenic failure in humans.,2021,10.7554/elife.65420,https://pubmed.ncbi.nlm.nih.gov/33781384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,26162009,Isoform-Level Gene Expression Profiles of Human Y Chromosome Azoospermia Factor Genes and Their X Chromosome Paralogs in the Testicular Tissue of Non-Obstructive Azoospermia Patients.,2015,10.1021/acs.jproteome.5b00520,https://pubmed.ncbi.nlm.nih.gov/26162009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,34274474,Identification of genomic imbalances (CNVs as well as LOH) in sertoli cell only syndrome cases through cytoscan microarray.,2021,10.1016/j.gene.2021.145851,https://pubmed.ncbi.nlm.nih.gov/34274474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,33575255,Genome-Scale CRISPR-Cas9 Transcriptional Activation Screening in Metformin Resistance Related Gene of Prostate Cancer.,2020,10.3389/fcell.2020.616332,https://pubmed.ncbi.nlm.nih.gov/33575255/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,24935076,Gene copy number alterations in the azoospermia-associated AZFc region and their effect on spermatogenic impairment.,2014,10.1093/molehr/gau043,https://pubmed.ncbi.nlm.nih.gov/24935076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,24828879,High-throughput screening for spermatogenesis candidate genes in the AZFc region of the Y chromosome by multiplex real time PCR followed by high resolution melting analysis.,2014,10.1371/journal.pone.0097227,https://pubmed.ncbi.nlm.nih.gov/24828879/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,12724276,Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility.,2003,10.1095/biolreprod.103.015792,https://pubmed.ncbi.nlm.nih.gov/12724276/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,26638807,Copy number variation and microdeletions of the Y chromosome linked genes and loci across different categories of Indian infertile males.,2015,10.1038/srep17780,https://pubmed.ncbi.nlm.nih.gov/26638807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,12207887,VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A.,2002,10.1016/s0006-291x(02)02040-5,https://pubmed.ncbi.nlm.nih.gov/12207887/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,14627543,"Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein.",2004,10.1095/biolreprod.103.018531,https://pubmed.ncbi.nlm.nih.gov/14627543/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,22844483,Organizational and functional status of the Y-linked genes and loci in the infertile patients having normal spermiogram.,2012,10.1371/journal.pone.0041488,https://pubmed.ncbi.nlm.nih.gov/22844483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,15676287,Identification in chromosome 8q11 of a region of homology with the g1 amplicon of the Y chromosome and functional analysis of the BEYLA gene.,2005,10.1016/j.ygeno.2004.10.015,https://pubmed.ncbi.nlm.nih.gov/15676287/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,16784771,Presence of TSPY transcript and absence of transcripts of other Y chromosomal genes in a case of microscopic gonadoblastoma.,2006,10.1016/j.ygyno.2006.05.010,https://pubmed.ncbi.nlm.nih.gov/16784771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,14666162,"Study of transcripts from AC010088, a 199,485 bp fragment of the human Y chromosome located in the azoospermia factor region c.",2002,,https://pubmed.ncbi.nlm.nih.gov/14666162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2,ENSG00000183753,Neither,20691057,Genetic integrity of the human Y chromosome exposed to groundwater arsenic.,2010,10.1186/1755-8794-3-35,https://pubmed.ncbi.nlm.nih.gov/20691057/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2B,ENSG00000183795,Neither,25799347,De novo origin of VCY2 from autosome to Y-transposed amplicon.,2015,10.1371/journal.pone.0119651,https://pubmed.ncbi.nlm.nih.gov/25799347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2B,ENSG00000183795,Neither,12724276,Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility.,2003,10.1095/biolreprod.103.015792,https://pubmed.ncbi.nlm.nih.gov/12724276/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2B,ENSG00000183795,Neither,12207887,VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A.,2002,10.1016/s0006-291x(02)02040-5,https://pubmed.ncbi.nlm.nih.gov/12207887/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2B,ENSG00000183795,Neither,14627543,"Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein.",2004,10.1095/biolreprod.103.018531,https://pubmed.ncbi.nlm.nih.gov/14627543/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2B,ENSG00000183795,Neither,15676287,Identification in chromosome 8q11 of a region of homology with the g1 amplicon of the Y chromosome and functional analysis of the BEYLA gene.,2005,10.1016/j.ygeno.2004.10.015,https://pubmed.ncbi.nlm.nih.gov/15676287/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2C,ENSG00000185894,Neither,25799347,De novo origin of VCY2 from autosome to Y-transposed amplicon.,2015,10.1371/journal.pone.0119651,https://pubmed.ncbi.nlm.nih.gov/25799347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2C,ENSG00000185894,Neither,32956593,The AC006262.5-miR-7855-5p-BPY2C axis facilitates hepatocellular carcinoma proliferation and migration.,2021,10.1139/bcb-2019-0239,https://pubmed.ncbi.nlm.nih.gov/32956593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2C,ENSG00000185894,Neither,12724276,Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility.,2003,10.1095/biolreprod.103.015792,https://pubmed.ncbi.nlm.nih.gov/12724276/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2C,ENSG00000185894,Neither,12207887,VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A.,2002,10.1016/s0006-291x(02)02040-5,https://pubmed.ncbi.nlm.nih.gov/12207887/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2C,ENSG00000185894,Neither,14627543,"Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein.",2004,10.1095/biolreprod.103.018531,https://pubmed.ncbi.nlm.nih.gov/14627543/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPY2C,ENSG00000185894,Neither,15676287,Identification in chromosome 8q11 of a region of homology with the g1 amplicon of the Y chromosome and functional analysis of the BEYLA gene.,2005,10.1016/j.ygeno.2004.10.015,https://pubmed.ncbi.nlm.nih.gov/15676287/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,40085698,Ectopic expression of testis-specific transcription elongation factor in driving cancer.,2025,10.1126/sciadv.ads4200,https://pubmed.ncbi.nlm.nih.gov/40085698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,42492506,BRD4: From molecular understanding to therapeutics development.,2026,10.1016/j.molcel.2026.07.004,https://pubmed.ncbi.nlm.nih.gov/42492506/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,41984625,"Structural Basis for BD1-Preferring 2,4-Disubstituted Pyrimidine BRDT Inhibitors.",2026,10.1021/acs.jmedchem.6c00180,https://pubmed.ncbi.nlm.nih.gov/41984625/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,41945432,Meiotic prophase I disruption as a strategy for nonhormonal male contraception using small-molecule inhibitor JQ1.,2026,10.1073/pnas.2517498123,https://pubmed.ncbi.nlm.nih.gov/41945432/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,40454210,Identification of Ferroptosis-Related Genes Associated With Cryptorchidism via Bioinformatics and Experimental Verification.,2025,10.1155/genr/7355474,https://pubmed.ncbi.nlm.nih.gov/40454210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,41049069,Bromodomain and Extraterminal Protein Inhibition: A Novel Therapeutic Strategy in Arthritis.,2025,10.2147/jir.s535057,https://pubmed.ncbi.nlm.nih.gov/41049069/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,42890222,Stage-specific transcriptional atlas of goose satellite cells uncovers sex-biased molecular dynamics associated with embryonic skeletal muscle development.,2026,10.3389/fcell.2026.1957937,https://pubmed.ncbi.nlm.nih.gov/42890222/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,42500561,Integrative Analysis Identified an Eight-Gene Risk Signature Linked to CDK7 and Explored Its Association with HCC Progression via RelA Phosphorylation.,2026,10.32604/or.2026.081711,https://pubmed.ncbi.nlm.nih.gov/42500561/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,40120495,Macrocyclic dihydropyridine analogs as pan-BET BD2-preferred inhibitors.,2025,10.1016/j.ejmech.2025.117504,https://pubmed.ncbi.nlm.nih.gov/40120495/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,36239350,The novel BRDT inhibitor NHWD870 shows potential as a male contraceptive in mice.,2022,10.3724/abbs.2022135,https://pubmed.ncbi.nlm.nih.gov/36239350/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,39422082,Novel Genes of the Male Reproductive System: Potential Roles in Male Reproduction and as Non-hormonal Male Contraceptive Targets.,2024,10.1002/mrd.70000,https://pubmed.ncbi.nlm.nih.gov/39422082/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,36077987,Genome-Wide Identification and Characterization of the BRD Family in Nile Tilapia (Oreochromis niloticus).,2022,10.3390/ani12172266,https://pubmed.ncbi.nlm.nih.gov/36077987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,38723266,Effect of dietary vitamin E supplement on the reproductive performance and gene expression profiling in Ompok bimaculatus during breeding period.,2024,10.1111/jpn.13982,https://pubmed.ncbi.nlm.nih.gov/38723266/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,39414017,Identification of candidate genes related to hybrid sterility by genomic structural variation and transcriptome analyses in cattle-yak.,2025,10.3168/jds.2024-24770,https://pubmed.ncbi.nlm.nih.gov/39414017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,37082969,DOT1L promotes spermatid differentiation by regulating expression of genes required for histone-to-protamine replacement.,2023,10.1242/dev.201497,https://pubmed.ncbi.nlm.nih.gov/37082969/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,35279966,Epigenetic Dysregulation of BRDT Gene in Testis Tissues of Infertile Men: Case-Control Study.,2022,10.22074/cellj.2022.7724,https://pubmed.ncbi.nlm.nih.gov/35279966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,33658703,Bromodomain protein BRDT directs ΔNp63 function and super-enhancer activity in a subset of esophageal squamous cell carcinomas.,2021,10.1038/s41418-021-00751-w,https://pubmed.ncbi.nlm.nih.gov/33658703/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,33257688,BRDT promotes ovarian cancer cell growth.,2020,10.1038/s41419-020-03225-y,https://pubmed.ncbi.nlm.nih.gov/33257688/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,35736136,H3K36me2 methyltransferase NSD2 orchestrates epigenetic reprogramming during spermatogenesis.,2022,10.1093/nar/gkac533,https://pubmed.ncbi.nlm.nih.gov/35736136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,37992310,A Phase I/II Study of GSK525762 Combined with Fulvestrant in Patients with Hormone Receptor-positive/HER2-negative Advanced or Metastatic Breast Cancer.,2024,10.1158/1078-0432.ccr-23-0133,https://pubmed.ncbi.nlm.nih.gov/37992310/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,35116104,Bromodomain and extra-terminal inhibitors emerge as potential therapeutic avenues for gastrointestinal cancers.,2022,10.4251/wjgo.v14.i1.75,https://pubmed.ncbi.nlm.nih.gov/35116104/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,37049806,BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications.,2023,10.3390/molecules28073043,https://pubmed.ncbi.nlm.nih.gov/37049806/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,35622893,Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections.,2022,10.1073/pnas.2122506119,https://pubmed.ncbi.nlm.nih.gov/35622893/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,33965371,Exposure to the bromodomain inhibitor N-methyl pyrrolidone blocks spermatogenesis in a hormonal and non-hormonal fashion.,2021,10.1016/j.taap.2021.115568,https://pubmed.ncbi.nlm.nih.gov/33965371/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,33637650,Discovery and characterization of bromodomain 2-specific inhibitors of BRDT.,2021,10.1073/pnas.2021102118,https://pubmed.ncbi.nlm.nih.gov/33637650/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,35565363,NUT Is a Driver of p300-Mediated Histone Hyperacetylation: From Spermatogenesis to Cancer.,2022,10.3390/cancers14092234,https://pubmed.ncbi.nlm.nih.gov/35565363/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,32019712,BET proteins: Investigating BRDT as a potential target for male contraception.,2020,10.1016/j.bmcl.2020.126958,https://pubmed.ncbi.nlm.nih.gov/32019712/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,32693114,Targeting BET bromodomain proteins in cancer: The example of lymphomas.,2020,10.1016/j.pharmthera.2020.107631,https://pubmed.ncbi.nlm.nih.gov/32693114/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,15647849,Molecular cloning and expression of a novel alternative splice variant of BRDT gene.,2005,10.3892/ijmm.15.2.315,https://pubmed.ncbi.nlm.nih.gov/15647849/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,10704737,"Expression of cancer-testis antigens in lung cancer: definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9.",2000,10.1016/s0304-3835(99)00385-7,https://pubmed.ncbi.nlm.nih.gov/10704737/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRDT,ENSG00000137948,Neither,9367677,Identification and characterization of BRDT: A testis-specific gene related to the bromodomain genes RING3 and Drosophila fsh.,1997,10.1006/geno.1997.5000,https://pubmed.ncbi.nlm.nih.gov/9367677/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,42609095,The Pineal Gland Is Required for Optimal Nighttime Immunity to Bacterial Infection in Larval Zebrafish.,2026,10.1111/jpi.70179,https://pubmed.ncbi.nlm.nih.gov/42609095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,41620616,MER57E3 transposable elements regulate gene expression in a human cell model of neural development.,2026,10.1186/s13059-026-03946-x,https://pubmed.ncbi.nlm.nih.gov/41620616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,40826119,Heart failure with preserved ejection fraction and obesity: emerging metabolic therapeutic strategies.,2025,10.1186/s13098-025-01917-z,https://pubmed.ncbi.nlm.nih.gov/40826119/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,39260480,Links between fecal microplastics and parameters related to metabolic dysfunction-associated steatotic liver disease (MASLD) in humans: An exploratory study.,2024,10.1016/j.scitotenv.2024.176153,https://pubmed.ncbi.nlm.nih.gov/39260480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,39052193,Effect of bariatric surgery on nutritional and metabolic parameters: does the type of antidepressant medication matter?,2024,10.1007/s40519-024-01680-6,https://pubmed.ncbi.nlm.nih.gov/39052193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,35249239,Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on mature pineal gland morphology and circadian behavior.,2022,10.1111/jpi.12795,https://pubmed.ncbi.nlm.nih.gov/35249239/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,37378669,Fetal origins of obesity: a novel pathway of regulating appetite neurons in the hypothalamus of growth-restricted rat offspring.,2024,10.1007/s00404-023-07108-3,https://pubmed.ncbi.nlm.nih.gov/37378669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,39978365,Evaluating the efficacy of basiliximab versus no induction in low-immunological-risk kidney transplant recipients: a propensity score matched analysis.,2025,10.1080/0886022x.2025.2460729,https://pubmed.ncbi.nlm.nih.gov/39978365/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,39711421,Zebrafish Dark-Dependent Behavior Requires Phototransduction by the Pineal Gland.,2024,10.1111/jpi.70021,https://pubmed.ncbi.nlm.nih.gov/39711421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,35307341,"Possible role of transcription factors (BSX, NKX2.1, IRX3 and SIRT1) in the regulation of appetite in goldfish (Carassius auratus).",2022,10.1016/j.cbpa.2022.111189,https://pubmed.ncbi.nlm.nih.gov/35307341/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,36302841,Fate mapping reveals mixed embryonic origin and unique developmental codes of mouse forebrain septal neurons.,2022,10.1038/s42003-022-04066-5,https://pubmed.ncbi.nlm.nih.gov/36302841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,42502885,Variability in Pacemaker Battery Estimates and Performance.,2026,10.1111/pace.70370,https://pubmed.ncbi.nlm.nih.gov/42502885/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,35715590,Basiliximab Does Not Impair Airway Mucociliary Clearance of Rats.,2022,10.1007/s10753-022-01687-0,https://pubmed.ncbi.nlm.nih.gov/35715590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,32581684,Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon.,2020,10.3389/fnins.2020.00525,https://pubmed.ncbi.nlm.nih.gov/32581684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,31808568,Circadian regulation and molecular role of the Bsx homeobox gene in the adult pineal gland.,2020,10.1111/jpi.12629,https://pubmed.ncbi.nlm.nih.gov/31808568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,37985223,Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease.,2024,10.1002/alz.13508,https://pubmed.ncbi.nlm.nih.gov/37985223/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,31602413,Brain-specific homeobox Bsx specifies identity of pineal gland between serially homologous photoreceptive organs in zebrafish.,2019,10.1038/s42003-019-0613-1,https://pubmed.ncbi.nlm.nih.gov/31602413/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,39482005,"Prenatal diagnosis of Jacobsen syndrome associated with a distal 11q deletion and a distal 8q duplication by chromosome microarray analysis in a fetus with a de novo unbalanced translocation of 46,XX,der(11)t(8;11)(q24.13;q23.3) and multiple congenital anomalies on fetal ultrasound.",2024,10.1016/j.tjog.2024.09.012,https://pubmed.ncbi.nlm.nih.gov/39482005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,36747359,The comparative efficacy and safety of basiliximab and antithymocyte globulin in deceased donor kidney transplantation: a multicenter cohort study.,2023,10.23876/j.krcp.21.159,https://pubmed.ncbi.nlm.nih.gov/36747359/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,29945867,Bsx controls pineal complex development.,2018,10.1242/dev.163477,https://pubmed.ncbi.nlm.nih.gov/29945867/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,42535542,Sex Differences in Outcomes by Revascularization Strategy in Patients With Femoropopliteal Peripheral Arterial Disease: A Substudy of the REVIVE Pooled Analysis.,2026,10.1161/jaha.125.042675,https://pubmed.ncbi.nlm.nih.gov/42535542/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,36819125,Very Low Dose Anti-Thymocyte Globulins Versus Basiliximab in Non-Immunized Kidney Transplant Recipients.,2023,10.3389/ti.2023.10816,https://pubmed.ncbi.nlm.nih.gov/36819125/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,35977904,Antithymocyte globulin versus basiliximab induction for kidney transplantation in elderly patients: matched analysis within the Korean multicentric registry.,2022,10.23876/j.krcp.21.310,https://pubmed.ncbi.nlm.nih.gov/35977904/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,36697136,Revascularization Strategies for Patients With Femoropopliteal Peripheral Artery Disease.,2023,10.1016/j.jacc.2022.10.036,https://pubmed.ncbi.nlm.nih.gov/36697136/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,32913585,The Effect of Monthly Anti-CD25+ Treatment with Basiliximab on the Progression of Chronic Renal Dysfunction after Lung Transplantation.,2020,,https://pubmed.ncbi.nlm.nih.gov/32913585/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,36031358,Impact of Guideline-Directed Medical Therapy on 10-Year Mortality after Revascularization for Patients with Chronic Limb-Threatening Ischemia.,2023,10.5551/jat.63773,https://pubmed.ncbi.nlm.nih.gov/36031358/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,29886215,Drug-Eluting Stent Shows Similar Patency Results as Prosthetic Bypass in Patients with Femoropopliteal Occlusion in a Randomized Trial.,2018,10.1016/j.avsg.2018.04.014,https://pubmed.ncbi.nlm.nih.gov/29886215/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,33091057,Induction therapy in kidney transplant recipients: Description of the practices according to the calendar period from the French multicentric DIVAT cohort.,2020,10.1371/journal.pone.0240929,https://pubmed.ncbi.nlm.nih.gov/33091057/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,28822457,[Meta analysis of clinical safety and efficacy evaluation of peripheral arterial disease patients with critical limb ischemia who accepted bypass surgery or endovascular therapy].,2017,10.3760/cma.j.issn.0376-2491.2017.30.012,https://pubmed.ncbi.nlm.nih.gov/28822457/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,26466986,Bypass Surgery vs. Drug-Eluting Stent for Trans-Atlantic Inter-Society Consensus-II (TASCII) C or D Femoropopliteal Lesions.,2015,10.1253/circj.cj-15-0597,https://pubmed.ncbi.nlm.nih.gov/26466986/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,26017642,Effect of bariatric surgery on cardiometabolic risk in elderly patients: A population-based study.,2016,10.1111/ggi.12527,https://pubmed.ncbi.nlm.nih.gov/26017642/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,23628918,Comparison of clinical outcome after bypass surgery vs. endovascular therapy for infrainguinal artery disease in patients with critical limb ischemia.,2013,10.1253/circj.cj-13-0020,https://pubmed.ncbi.nlm.nih.gov/23628918/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,20435259,Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial: Analysis of amputation free and overall survival by treatment received.,2010,10.1016/j.jvs.2010.01.074,https://pubmed.ncbi.nlm.nih.gov/20435259/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,26508906,Lymphocyte Activation Markers in Pediatric Kidney Transplant Recipients.,2015,10.59566/ijbs.2015.11121,https://pubmed.ncbi.nlm.nih.gov/26508906/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,20006808,Bypass versus angioplasty in severe ischaemia of the leg (BASIL) trial: what are its implications?,2009,10.1053/j.semvascsurg.2009.10.010,https://pubmed.ncbi.nlm.nih.gov/20006808/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSX,ENSG00000188909,Neither,33877510,Single-center thorough evaluation and targeted treatment of globozoospermic men.,2021,10.1007/s10815-021-02191-4,https://pubmed.ncbi.nlm.nih.gov/33877510/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTBD18,ENSG00000233436,Neither,33831001,Sperm acrosome overgrowth and infertility in mice lacking chromosome 18 pachytene piRNA.,2021,10.1371/journal.pgen.1009485,https://pubmed.ncbi.nlm.nih.gov/33831001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTBD18,ENSG00000233436,Neither,28292424,BTBD18 Regulates a Subset of piRNA-Generating Loci through Transcription Elongation in Mice.,2017,10.1016/j.devcel.2017.02.007,https://pubmed.ncbi.nlm.nih.gov/28292424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1QL4,ENSG00000186897,Neither,42409806,The deubiquitinase USP25 contributes to stemness and malignant progression of breast cancer by stabilizing C1ql4.,2026,10.1038/s41598-026-49272-x,https://pubmed.ncbi.nlm.nih.gov/42409806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1QL4,ENSG00000186897,Neither,40702255,Prognostic implications of complement C1q-like 4 expression in breast cancer.,2025,10.1038/s41598-025-12557-8,https://pubmed.ncbi.nlm.nih.gov/40702255/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1QL4,ENSG00000186897,Neither,35579659,CTRP11 contributes modestly to systemic metabolism and energy balance.,2022,10.1096/fj.202200189rr,https://pubmed.ncbi.nlm.nih.gov/35579659/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1QL4,ENSG00000186897,Neither,37324011,C1ql4 regulates breast cancer cell stemness and epithelial-mesenchymal transition through PI3K/AKT/NF-κB signaling pathway.,2023,10.3389/fonc.2023.1192482,https://pubmed.ncbi.nlm.nih.gov/37324011/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1QL4,ENSG00000186897,Neither,27734226,C1ql1/Ctrp14 and C1ql4/Ctrp11 promote angiogenesis of endothelial cells through activation of ERK1/2 signal pathway.,2017,10.1007/s11010-016-2842-7,https://pubmed.ncbi.nlm.nih.gov/27734226/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1QL4,ENSG00000186897,Neither,37901246,Multi-faceted roles of C1q/TNF-related proteins family in atherosclerosis.,2023,10.3389/fimmu.2023.1253433,https://pubmed.ncbi.nlm.nih.gov/37901246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1QL4,ENSG00000186897,Neither,30608882,Expression patterns of C1ql4 and its cell-adhesion GPCR Bai3 in the murine testis and functional roles in steroidogenesis.,2019,10.1096/fj.201801620rr,https://pubmed.ncbi.nlm.nih.gov/30608882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1QL4,ENSG00000186897,Neither,36128744,Association Between Novel Pro- and Anti- Inflammatory Adipocytokines in Patients with Acute Coronary Syndrome.,2022,10.1177/10760296221128021,https://pubmed.ncbi.nlm.nih.gov/36128744/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1QL4,ENSG00000186897,Neither,37371880,Transcriptome Analysis Reveals the Genes Involved in Oxidative Stress Responses of Scallop to PST-Producing Algae and a Candidate Biomarker for PST Monitoring.,2023,10.3390/antiox12061150,https://pubmed.ncbi.nlm.nih.gov/37371880/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1QL4,ENSG00000186897,Neither,34238116,Identification of key genes involved in the recurrence of glioblastoma multiforme using weighted gene co-expression network analysis and differential expression analysis.,2021,10.1080/21655979.2021.1943986,https://pubmed.ncbi.nlm.nih.gov/34238116/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1QL4,ENSG00000186897,Neither,38750748,Physiological and transcriptomic analysis provides new insights into osmoregulation mechanism of Ruditapes philippinarum under low and high salinity stress.,2024,10.1016/j.scitotenv.2024.173215,https://pubmed.ncbi.nlm.nih.gov/38750748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1QL4,ENSG00000186897,Neither,23449976,"C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis.",2013,10.1074/jbc.m113.458711,https://pubmed.ncbi.nlm.nih.gov/23449976/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1QL4,ENSG00000186897,Neither,30367035,Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion.,2018,10.1038/s41467-018-06897-5,https://pubmed.ncbi.nlm.nih.gov/30367035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1QL4,ENSG00000186897,Neither,21262840,The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins.,2011,10.1073/pnas.1019577108,https://pubmed.ncbi.nlm.nih.gov/21262840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1QL4,ENSG00000186897,Neither,20525073,Distinct expression of C1q-like family mRNAs in mouse brain and biochemical characterization of their encoded proteins.,2010,10.1111/j.1460-9568.2010.07202.x,https://pubmed.ncbi.nlm.nih.gov/20525073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,42805180,"A single ROSA26 mouse line for robust tdTomato labeling with Cre, FLP, Dre, Vika, SCre, and VCre recombinases.",2026,10.1016/j.crmeth.2026.101611,https://pubmed.ncbi.nlm.nih.gov/42805180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,37215460,Predicting the effects of supply chain resilience and robustness on COVID-19 impacts and performance: Empirical investigation through resources orchestration perspective.,2023,10.1016/j.jbusres.2023.114025,https://pubmed.ncbi.nlm.nih.gov/37215460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,37259460,Protective Potential of Saussurea costus (Falc.) Lipsch. Roots against Cyclophosphamide-Induced Pulmonary Injury in Rats and Its In Vitro Antiviral Effect.,2023,10.3390/ph16020318,https://pubmed.ncbi.nlm.nih.gov/37259460/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,38213995,TSCRE: a comprehensive database for tumor-specific &lt;i&gt;cis&lt;/i&gt;-regulatory elements.,2024,10.1093/narcan/zcad063,https://pubmed.ncbi.nlm.nih.gov/38213995/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,39497087,Clinical manifestations and treatment of candidemia caused by different Candida species: a retrospective study.,2024,10.1186/s12879-024-10128-2,https://pubmed.ncbi.nlm.nih.gov/39497087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,30949703,SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice.,2019,10.1093/nar/gkz226,https://pubmed.ncbi.nlm.nih.gov/30949703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,35637044,Association between serum creatinine level within normal range and bone mineral density in adolescents.,2022,10.1016/j.arcped.2022.05.002,https://pubmed.ncbi.nlm.nih.gov/35637044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,37513365,Single versus Double Coffee-Ring Effect Patterns in Thin-Layer Chromatography Coupled with Surface-Enhanced Raman Spectroscopic Analysis of Anti-Diabetic Drugs Adulterated in Herbal Products.,2023,10.3390/molecules28145492,https://pubmed.ncbi.nlm.nih.gov/37513365/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,38821762,Evaluation of new predictive scores for sudden cardiac death in childhood hypertrophic cardiomyopathy in a French cohort.,2024,10.1016/j.acvd.2024.03.003,https://pubmed.ncbi.nlm.nih.gov/38821762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,38516174,Crossed renal ectopia: A case report and review of the literature.,2024,10.1016/j.eucr.2024.102690,https://pubmed.ncbi.nlm.nih.gov/38516174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,32087614,Renal expression and urinary excretion of liver-type fatty acid-binding protein in cats with renal disease.,2020,10.1111/jvim.15721,https://pubmed.ncbi.nlm.nih.gov/32087614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,38372694,Interactions between calcium-induced arrhythmia triggers and the electrophysiological-anatomical substrate underlying the induction of atrial fibrillation.,2024,10.1113/jp285740,https://pubmed.ncbi.nlm.nih.gov/38372694/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,34114400,Full composition granules of Huanglian (Rhizoma Coptidis) decrease the serum monocyte chemotactic protein-1 and connective tissue growth factor levels and inhibit kidney nuclear factor-κB expression in rats with high-fat diet-induced diabete.,2021,10.19852/j.cnki.jtcm.2021.03.010,https://pubmed.ncbi.nlm.nih.gov/34114400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,37149572,Risk factors analysis of surgical complications of hepatic hemangioma: a modified Clavien-Dindo classification-based study.,2023,10.1186/s12893-023-02009-3,https://pubmed.ncbi.nlm.nih.gov/37149572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,35002082,Supply chain resilience in the UK during the coronavirus pandemic: A resource orchestration perspective.,2022,10.1016/j.ijpe.2021.108405,https://pubmed.ncbi.nlm.nih.gov/35002082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,37900526,Impacts of Skin Color and Hypoxemia on Noninvasive Assessment of Peripheral Blood Oxygen Saturation: A Scoping Review.,2023,10.7759/cureus.46078,https://pubmed.ncbi.nlm.nih.gov/37900526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,31393876,Arrhythmia mechanisms and spontaneous calcium release: Bi-directional coupling between re-entrant and focal excitation.,2019,10.1371/journal.pcbi.1007260,https://pubmed.ncbi.nlm.nih.gov/31393876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,31755150,Deletion of Ck2β gene causes germ cell development arrest and azoospermia in male mice.,2020,10.1111/cpr.12726,https://pubmed.ncbi.nlm.nih.gov/31755150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,34940057,Association between Ureteral Clamping Time and Acute Kidney Injury during Robot-Assisted Radical Cystectomy.,2021,10.3390/curroncol28060418,https://pubmed.ncbi.nlm.nih.gov/34940057/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,36797795,Exploration of the anti-hyperuricemia effect of TongFengTangSan (TFTS) by UPLC-Q-TOF/MS-based non-targeted metabonomics.,2023,10.1186/s13020-023-00716-w,https://pubmed.ncbi.nlm.nih.gov/36797795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,42288161,"Multidimensional pharmacological evaluation of Umbilicus horizontalis (Guss.) DC. leaves and stems: Antioxidant, anti-inflammatory, analgesic, and cholinesterase inhibitory activities.",2026,10.1016/j.jep.2026.121997,https://pubmed.ncbi.nlm.nih.gov/42288161/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,37209608,Amelioration effects of α-viniferin on hyperuricemia and hyperuricemia-induced kidney injury in mice.,2023,10.1016/j.phymed.2023.154868,https://pubmed.ncbi.nlm.nih.gov/37209608/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,32557260,Pre-dialysis serum creatinine as an independent predictor of responsiveness to zinc supplementation among patients on hemodialysis.,2020,10.1007/s10157-020-01911-x,https://pubmed.ncbi.nlm.nih.gov/32557260/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,30941453,Infrahepatic Inferior Vena Cava Semi-Clamping can Reduce Blood Loss During Hepatic Resection but Still Requires Monitoring to Avoid Acute Kidney Injury.,2019,10.1007/s00268-019-04992-2,https://pubmed.ncbi.nlm.nih.gov/30941453/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,32161806,Improving the efficiency of gene insertion in a human artificial chromosome vector and its transfer in human-induced pluripotent stem cells.,2018,10.1093/biomethods/bpy013,https://pubmed.ncbi.nlm.nih.gov/32161806/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,24128070,Application of emerging biomarkers of acute kidney injury in development of kidney-sparing polypeptide-based antibiotics.,2014,10.3109/01480545.2013.834360,https://pubmed.ncbi.nlm.nih.gov/24128070/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,23413781,The lack of benefit of a combination of an angiotensin receptor blocker and calcium channel blocker on contrast-induced nephropathy in patients with chronic kidney disease.,2013,10.3109/0886022x.2013.766566,https://pubmed.ncbi.nlm.nih.gov/23413781/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,26949541,Feasibility study of short hydration using oral rehydration solution in cisplatin including chemotherapy of lung cancer.,2016,10.1186/s40780-016-0041-z,https://pubmed.ncbi.nlm.nih.gov/26949541/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,26979596,Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors.,2016,10.1186/s12885-016-2271-8,https://pubmed.ncbi.nlm.nih.gov/26979596/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,22943953,[Percutaneous pelvic fracture stabilization using CT-based 3D navigation software combined with targeting mechanical arm: a cadaver model trial].,2012,,https://pubmed.ncbi.nlm.nih.gov/22943953/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,29348903,The systemic inflammation-based Glasgow Prognostic Score as a powerful prognostic factor in patients with upper tract urothelial carcinoma.,2017,10.18632/oncotarget.22641,https://pubmed.ncbi.nlm.nih.gov/29348903/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,15072506,Radiocontrast-induced nephrotoxicity and urinary alpha-glutathione S-transferase levels: effect of amlodipine administration.,2003,10.1023/b:urol.0000020186.72345.ec,https://pubmed.ncbi.nlm.nih.gov/15072506/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf146,ENSG00000203910,Neither,7670559,Leuprolide acetate prevents toxic effects of cisplatin on the kidneys and gastrointestinal tract.,1995,10.1507/endocrj.42.315,https://pubmed.ncbi.nlm.nih.gov/7670559/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C3orf20,ENSG00000131379,Neither,35456561,Associations between the C3orf20 rs12496846 Polymorphism and Both Postoperative Analgesia after Orthognathic and Abdominal Surgeries and C3orf20 Gene Expression in the Brain.,2022,10.3390/pharmaceutics14040727,https://pubmed.ncbi.nlm.nih.gov/35456561/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C3orf20,ENSG00000131379,Neither,38407877,Molecular subtype identification and prognosis stratification by a immunogenic cell death-related gene expression signature in colorectal cancer.,2024,10.1080/14737140.2024.2320187,https://pubmed.ncbi.nlm.nih.gov/38407877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C3orf20,ENSG00000131379,Neither,26616883,Exome and regulatory element sequencing of neuromyelitis optica patients.,2015,10.1016/j.jneuroim.2015.11.002,https://pubmed.ncbi.nlm.nih.gov/26616883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C4orf17,ENSG00000138813,Neither,18336583,Novel genes involved in canonical Wnt/beta-catenin signaling pathway in early Ciona intestinalis embryos.,2008,10.1111/j.1440-169x.2008.01012.x,https://pubmed.ncbi.nlm.nih.gov/18336583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C8orf74,ENSG00000171060,Neither,31447886,Novel Gene-Based Analysis of ASD GWAS: Insight Into the Biological Role of Associated Genes.,2019,10.3389/fgene.2019.00733,https://pubmed.ncbi.nlm.nih.gov/31447886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAGE1,ENSG00000164304,Neither,40359694,Cancer-testis antigen expression in canine melanoma and healthy tissues.,2025,10.1016/j.vetimm.2025.110946,https://pubmed.ncbi.nlm.nih.gov/40359694/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAGE1,ENSG00000164304,Neither,36948524,Whole exon capture sequencing for identifying mutations associated with pulmonary benign metastasising leiomyoma.,2023,10.1136/bcr-2022-251072,https://pubmed.ncbi.nlm.nih.gov/36948524/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAGE1,ENSG00000164304,Neither,35791046,Transcriptomic landscape of GC-2spd(ts) cell in response to the downregulation of piR-1207/2107.,2022,10.1111/and.14522,https://pubmed.ncbi.nlm.nih.gov/35791046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAGE1,ENSG00000164304,Neither,35289007,CAGEs are Golgi-localized GT31 enzymes involved in cellulose biosynthesis in Arabidopsis.,2022,10.1111/tpj.15734,https://pubmed.ncbi.nlm.nih.gov/35289007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAGE1,ENSG00000164304,Neither,31832140,CRISPRa-mediated FOXP3 gene upregulation in mammalian cells.,2019,10.1186/s13578-019-0357-0,https://pubmed.ncbi.nlm.nih.gov/31832140/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAGE1,ENSG00000164304,Neither,24604048,Expressional regulation of genes linked to immunity & programmed development in human early placental villi.,2014,,https://pubmed.ncbi.nlm.nih.gov/24604048/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAGE1,ENSG00000164304,Neither,22969913,Comparative proteomic analysis of the function and network mechanisms of MASPIN in human lung cells.,2012,10.3892/etm.2011.427,https://pubmed.ncbi.nlm.nih.gov/22969913/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAGE1,ENSG00000164304,Neither,3008088,The MURFI linker for multiple reading frame insertion of a sense or nonsense codon into DNA.,1986,10.1093/nar/14.5.2139,https://pubmed.ncbi.nlm.nih.gov/3008088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAGE1,ENSG00000164304,Neither,36885218,The Effect of High Frequency Currents upon Blood Pressure. Demonstration of the D'Arsonval Cage.,1909,,https://pubmed.ncbi.nlm.nih.gov/36885218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN11,ENSG00000137225,Neither,42162411,Non-Mendelian inheritance of DNA methylation patterns in mice.,2026,10.1038/s41588-026-02604-z,https://pubmed.ncbi.nlm.nih.gov/42162411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN11,ENSG00000137225,Neither,37155670,"ZFP92, a KRAB domain zinc finger protein enriched in pancreatic islets, binds to B1/Alu SINE transposable elements and regulates retroelements and genes.",2023,10.1371/journal.pgen.1010729,https://pubmed.ncbi.nlm.nih.gov/37155670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN11,ENSG00000137225,Neither,36672262,Sex-Specific Whole-Transcriptome Analysis in the Cerebral Cortex of FAE Offspring.,2023,10.3390/cells12020328,https://pubmed.ncbi.nlm.nih.gov/36672262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN11,ENSG00000137225,Neither,29770609,Whole-exome sequencing for variant discovery in blepharospasm.,2018,10.1002/mgg3.411,https://pubmed.ncbi.nlm.nih.gov/29770609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN11,ENSG00000137225,Neither,32432769,The gene regulatory network in different brain regions of neuropathic pain mouse models.,2020,10.26355/eurrev_202005_21198,https://pubmed.ncbi.nlm.nih.gov/32432769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN11,ENSG00000137225,Neither,20223856,"A newly classified vertebrate calpain protease, directly ancestral to CAPN1 and 2, episodically evolved a restricted physiological function in placental mammals.",2010,10.1093/molbev/msq071,https://pubmed.ncbi.nlm.nih.gov/20223856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN11,ENSG00000137225,Neither,35451555,A genome-wide association study of obstructive heart defects among participants in the National Birth Defects Prevention Study.,2022,10.1002/ajmg.a.62759,https://pubmed.ncbi.nlm.nih.gov/35451555/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN11,ENSG00000137225,Neither,30130361,Exposure to a firefighting overhaul environment without respiratory protection increases immune dysregulation and lung disease risk.,2018,10.1371/journal.pone.0201830,https://pubmed.ncbi.nlm.nih.gov/30130361/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN11,ENSG00000137225,Neither,24012201,Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis.,2013,10.1016/j.fertnstert.2013.07.1999,https://pubmed.ncbi.nlm.nih.gov/24012201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN11,ENSG00000137225,Neither,24718597,"Characterization of the definitive classical calpain family of vertebrates using phylogenetic, evolutionary and expression analyses.",2014,10.1098/rsob.130219,https://pubmed.ncbi.nlm.nih.gov/24718597/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN11,ENSG00000137225,Neither,10409436,CAPN11: A calpain with high mRNA levels in testis and located on chromosome 6.,1999,10.1006/geno.1999.5859,https://pubmed.ncbi.nlm.nih.gov/10409436/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN11,ENSG00000137225,Neither,20093171,"Characterisation of capn1, capn2-like, capn3 and capn11 genes in Atlantic halibut (Hippoglossus hippoglossus L.): Transcriptional regulation across tissues and in skeletal muscle at distinct nutritional states.",2010,10.1016/j.gene.2010.01.002,https://pubmed.ncbi.nlm.nih.gov/20093171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN11,ENSG00000137225,Neither,10559499,"Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development.",1999,10.1016/s0925-4773(99)00214-2,https://pubmed.ncbi.nlm.nih.gov/10559499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN11,ENSG00000137225,Neither,11523006,Both the conserved and the unique gene structure of stomach-specific calpains reveal processes of calpain gene evolution.,2001,10.1007/s002390010209,https://pubmed.ncbi.nlm.nih.gov/11523006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC166,ENSG00000255181,Neither,41630526,FAM216A and CCDC166 are not essential for male fertility.,2026,10.1071/rd25178,https://pubmed.ncbi.nlm.nih.gov/41630526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC168,ENSG00000175820,Neither,41969585,Whole-exome sequencing unveils novel potential gene mutations involved in primary renal small cell carcinoma.,2026,10.3892/ol.2026.15556,https://pubmed.ncbi.nlm.nih.gov/41969585/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC168,ENSG00000175820,Neither,42032772,Sex-aware genome-wide assessment of de novo variants in autism across coding and noncoding regions.,2026,10.1186/s40246-026-00961-8,https://pubmed.ncbi.nlm.nih.gov/42032772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC168,ENSG00000175820,Neither,39134585,Somatic mutational landscape across Indian breast cancer cases by whole exome sequencing.,2024,10.1038/s41598-024-65148-4,https://pubmed.ncbi.nlm.nih.gov/39134585/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC168,ENSG00000175820,Neither,36259570,Identification of risk genes in Chinese nonobstructive azoospermia patients based on whole-exome sequencing.,2023,10.4103/aja202275,https://pubmed.ncbi.nlm.nih.gov/36259570/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC168,ENSG00000175820,Neither,35445187,The genomic landscape of pediatric renal cell carcinomas.,2022,10.1016/j.isci.2022.104167,https://pubmed.ncbi.nlm.nih.gov/35445187/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC168,ENSG00000175820,Neither,38715151,Exploring the genetic control of sweat gland characteristics in beef cattle for enhanced heat tolerance.,2024,10.1186/s40104-024-01025-4,https://pubmed.ncbi.nlm.nih.gov/38715151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC168,ENSG00000175820,Neither,37373553,Identification of Somatic Mutations in Plasma Cell-Free DNA from Patients with Metastatic Oral Squamous Cell Carcinoma.,2023,10.3390/ijms241210408,https://pubmed.ncbi.nlm.nih.gov/37373553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC168,ENSG00000175820,Neither,36645718,Whole-exome sequencing of rectal neuroendocrine tumors.,2023,10.1530/erc-22-0257,https://pubmed.ncbi.nlm.nih.gov/36645718/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC168,ENSG00000175820,Neither,33691361,[Expression and clinical significance of SETD2 in maligant pleural mesothelioma].,2021,10.3760/cma.j.cn121094-20200831-00505,https://pubmed.ncbi.nlm.nih.gov/33691361/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC168,ENSG00000175820,Neither,30281678,Whole-exome sequencing capture kit biases yield false negative mutation calls in TCGA cohorts.,2018,10.1371/journal.pone.0204912,https://pubmed.ncbi.nlm.nih.gov/30281678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC169-SOHLH2,ENSG00000250709,Neither,35187167,Identification of a Five-Gene Panel to Assess Prognosis for Gastric Cancer.,2022,10.1155/2022/5593619,https://pubmed.ncbi.nlm.nih.gov/35187167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC169-SOHLH2,ENSG00000250709,Neither,32462188,Flexible Mixture Model Approaches That Accommodate Footprint Size Variability for Robust Detection of Balancing Selection.,2020,10.1093/molbev/msaa134,https://pubmed.ncbi.nlm.nih.gov/32462188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC169-SOHLH2,ENSG00000250709,Neither,27895115,Shared Subunits of Tetrahymena Telomerase Holoenzyme and Replication Protein A Have Different Functions in Different Cellular Complexes.,2017,10.1074/jbc.m116.763664,https://pubmed.ncbi.nlm.nih.gov/27895115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC169-SOHLH2,ENSG00000250709,Neither,25225329,Direct single-stranded DNA binding by Teb1 mediates the recruitment of Tetrahymena thermophila telomerase to telomeres.,2014,10.1128/mcb.01030-14,https://pubmed.ncbi.nlm.nih.gov/25225329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC169-SOHLH2,ENSG00000250709,Neither,23314747,Myb-domain protein Teb1 controls histone levels and centromere assembly in fission yeast.,2013,10.1038/emboj.2012.339,https://pubmed.ncbi.nlm.nih.gov/23314747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC169-SOHLH2,ENSG00000250709,Neither,22143754,Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA.,2011,10.1073/pnas.1113624108,https://pubmed.ncbi.nlm.nih.gov/22143754/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC169-SOHLH2,ENSG00000250709,Neither,20363756,Multiple mechanisms for elongation processivity within the reconstituted tetrahymena telomerase holoenzyme.,2010,10.1074/jbc.m110.119172,https://pubmed.ncbi.nlm.nih.gov/20363756/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC169-SOHLH2,ENSG00000250709,Neither,27901072,Characterisation of functional domains in fission yeast Ams2 that are required for core histone gene transcription.,2016,10.1038/srep38111,https://pubmed.ncbi.nlm.nih.gov/27901072/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC169-SOHLH2,ENSG00000250709,Neither,23918804,"Tetrahymena telomerase holoenzyme assembly, activation, and inhibition by domains of the p50 central hub.",2013,10.1128/mcb.00792-13,https://pubmed.ncbi.nlm.nih.gov/23918804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC169-SOHLH2,ENSG00000250709,Neither,26472759,"Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions.",2015,10.1126/science.aab4070,https://pubmed.ncbi.nlm.nih.gov/26472759/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC169-SOHLH2,ENSG00000250709,Neither,23552895,The architecture of Tetrahymena telomerase holoenzyme.,2013,10.1038/nature12062,https://pubmed.ncbi.nlm.nih.gov/23552895/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC182,ENSG00000166329,Neither,40572022,Mouse genome engineering uncovers 18 genes dispensable for male reproduction.,2026,10.1111/andr.70088,https://pubmed.ncbi.nlm.nih.gov/40572022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC183,ENSG00000213213,Neither,40685790,Epigenetic Activation of CCDC183-AS1 Promotes Osteoclastogenesis and Prostate Cancer Bone Metastasis Through the FUBP1/LIGHT Axis.,2025,10.1002/advs.202413288,https://pubmed.ncbi.nlm.nih.gov/40685790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC183,ENSG00000213213,Neither,37882665,CCDC183 is essential for cytoplasmic invagination around the flagellum during spermiogenesis and male fertility.,2023,10.1242/dev.201724,https://pubmed.ncbi.nlm.nih.gov/37882665/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC183,ENSG00000213213,Neither,36446526,Transcriptome analyses in infertile men reveal germ cell-specific expression and splicing patterns.,2023,10.26508/lsa.202201633,https://pubmed.ncbi.nlm.nih.gov/36446526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC183,ENSG00000213213,Neither,37038005,Multimodal immunogenomic biomarker analysis of tumors from pediatric patients enrolled to a phase 1-2 study of single-agent atezolizumab.,2023,10.1038/s43018-023-00534-x,https://pubmed.ncbi.nlm.nih.gov/37038005/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC183,ENSG00000213213,Neither,35957803,MITF-Mediated lncRNA CCDC183-As1 Promotes the Tumorigenic Properties and Aerobic Glycolysis of Bladder Cancer via Upregulating TCF7L2.,2022,10.1155/2022/6785956,https://pubmed.ncbi.nlm.nih.gov/35957803/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC183,ENSG00000213213,Neither,33541391,Long non-coding RNA CCDC183-AS1 acts AS a miR-589-5p sponge to promote the progression of hepatocellular carcinoma through regulating SKP1 expression.,2021,10.1186/s13046-021-01861-6,https://pubmed.ncbi.nlm.nih.gov/33541391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC183,ENSG00000213213,Neither,35119084,Molecular mechanism of  atractylon in the invasion and migration of hepatic cancer cells based on high‑throughput sequencing.,2022,10.3892/mmr.2022.12628,https://pubmed.ncbi.nlm.nih.gov/35119084/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC183,ENSG00000213213,Neither,37304675,"Long noncoding RNA CCDC183-AS1 depletion represses breast cancer cell proliferation, colony formation, and motility by sponging microRNA-3918.",2021,10.32604/or.2022.03573,https://pubmed.ncbi.nlm.nih.gov/37304675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC183,ENSG00000213213,Neither,39323814,Prognostic signature and immune landscape of 5-methylcytosine-related long non-coding RNAs in gastric cancer.,2024,10.1016/j.heliyon.2024.e37290,https://pubmed.ncbi.nlm.nih.gov/39323814/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC183,ENSG00000213213,Neither,33064489,The Functionally Unannotated Proteome of Human Male Tissues: A Shared Resource to Uncover New Protein Functions Associated with Reproductive Biology.,2020,10.1021/acs.jproteome.0c00516,https://pubmed.ncbi.nlm.nih.gov/33064489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC183,ENSG00000213213,Neither,34072005,Genomic Markers for Essential Tremor.,2021,10.3390/ph14060516,https://pubmed.ncbi.nlm.nih.gov/34072005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC183,ENSG00000213213,Neither,33279834,Exome-wide rare variant analysis in familial essential tremor.,2021,10.1016/j.parkreldis.2020.11.021,https://pubmed.ncbi.nlm.nih.gov/33279834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC183,ENSG00000213213,Neither,36609218,Three-dimensional genome landscape comprehensively reveals patterns of spatial gene regulation in papillary and anaplastic thyroid cancers: a study using representative cell lines for each cancer type.,2023,10.1186/s11658-022-00409-6,https://pubmed.ncbi.nlm.nih.gov/36609218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC197,ENSG00000175699,Neither,33126901,Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility.,2020,10.1186/s12958-020-00660-6,https://pubmed.ncbi.nlm.nih.gov/33126901/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,40371706,scRNA-seq and scATAC-seq reveal that Sertoli cell mediates spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia.,2025,10.7554/elife.97958,https://pubmed.ncbi.nlm.nih.gov/40371706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,40346136,Patient-specific gene co-expression networks reveal novel subtypes and predictive biomarkers in lung adenocarcinoma.,2025,10.1038/s41540-025-00522-0,https://pubmed.ncbi.nlm.nih.gov/40346136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,41516281,Weighted Gene Co-Expression Network Analysis and Alternative Splicing Analysis Reveal Key Genes Regulating Overfeeding-Induced Fatty Liver in Lion-Head Goose.,2025,10.3390/ijms27010407,https://pubmed.ncbi.nlm.nih.gov/41516281/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,42048856,A high-resolution plasma proteomic framework for stratifying treatment resistance and ultra-resistance in schizophrenia.,2026,10.1016/j.schres.2026.04.022,https://pubmed.ncbi.nlm.nih.gov/42048856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,36979316,"Genetics of Neurogenic Orthostatic Hypotension in Parkinson's Disease, Results from a Cross-Sectional In Silico Study.",2023,10.3390/brainsci13030506,https://pubmed.ncbi.nlm.nih.gov/36979316/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,36926335,Quantitative and causal analysis for inflammatory genes and the risk of Parkinson's disease.,2023,10.3389/fimmu.2023.1119315,https://pubmed.ncbi.nlm.nih.gov/36926335/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,36247236,"The integrative network of circRNA, miRNA and mRNA of epicardial adipose tissue in patients with atrial fibrillation.",2022,,https://pubmed.ncbi.nlm.nih.gov/36247236/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,31985809,Exome sequencing reveals novel causes as well as new candidate genes for human globozoospermia.,2020,10.1093/humrep/dez246,https://pubmed.ncbi.nlm.nih.gov/31985809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,36047070,Globozoospermia: A Case Report and Systematic Review of Literature.,2023,10.5534/wjmh.220020,https://pubmed.ncbi.nlm.nih.gov/36047070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,28339613,A nonsense mutation in Ccdc62 gene is responsible for spermiogenesis defects and male infertility in repro29/repro29 mice.,2017,10.1095/biolreprod.116.141408,https://pubmed.ncbi.nlm.nih.gov/28339613/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,35936781,Clinical Eosinophil-Associated Genes can Serve as a Reliable Predictor of Bladder Urothelial Cancer.,2022,10.3389/fmolb.2022.963455,https://pubmed.ncbi.nlm.nih.gov/35936781/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,35654582,FSIP2 plays a role in the acrosome development during spermiogenesis.,2023,10.1136/jmedgenet-2021-108406,https://pubmed.ncbi.nlm.nih.gov/35654582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,19165854,Identification of CCDC62-2 as a novel cancer/testis antigen and its immunogenicity.,2009,10.1002/ijc.24220,https://pubmed.ncbi.nlm.nih.gov/19165854/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,24312176,Genetic association study between STK39 and CCDC62/HIP1R and Parkinson's disease.,2013,10.1371/journal.pone.0079211,https://pubmed.ncbi.nlm.nih.gov/24312176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,27504496,Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci.,2016,10.1212/nxg.0000000000000090,https://pubmed.ncbi.nlm.nih.gov/27504496/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,19126643,CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells.,2009,10.1093/carcin/bgn288,https://pubmed.ncbi.nlm.nih.gov/19126643/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,27035708,Possible association of CCDC62 rs12817488 polymorphism and Parkinson's disease risk in Chinese population: a meta-analysis.,2016,10.1038/srep23991,https://pubmed.ncbi.nlm.nih.gov/27035708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,31404238,Genetic risk of Parkinson disease and progression:: An analysis of 13 longitudinal cohorts.,2019,10.1212/nxg.0000000000000348,https://pubmed.ncbi.nlm.nih.gov/31404238/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,24335092,CCDC62 variant rs12817488 is associated with the risk of Parkinson's disease in a Han Chinese population.,2014,10.1159/000354333,https://pubmed.ncbi.nlm.nih.gov/24335092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,24514572,Association of Parkinson disease risk loci with mild parkinsonian signs in older persons.,2014,10.1001/jamaneurol.2013.6222,https://pubmed.ncbi.nlm.nih.gov/24514572/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC62,ENSG00000130783,Neither,22254151,The neuroprotective disease-modifying potential of psychotropics in Parkinson's disease.,2012,10.1155/2012/753548,https://pubmed.ncbi.nlm.nih.gov/22254151/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC73,ENSG00000186714,Neither,40898283,DNAH10 mutation cause primary ciliary dyskinesia with defects of IDAf complex assembly and lung fibrosis manifestation.,2025,10.1186/s13023-025-03977-w,https://pubmed.ncbi.nlm.nih.gov/40898283/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC73,ENSG00000186714,Neither,41645336,Genomic analysis reveals convergent signatures of selection for milk traits in sheep and goats.,2026,10.1186/s40104-025-01334-2,https://pubmed.ncbi.nlm.nih.gov/41645336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC73,ENSG00000186714,Neither,29563520,"The evolutionarily conserved genes: Tex37, Ccdc73, Prss55 and Nxt2 are dispensable for fertility in mice.",2018,10.1038/s41598-018-23176-x,https://pubmed.ncbi.nlm.nih.gov/29563520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC73,ENSG00000186714,Neither,35281414,Analysis of prognostic and therapeutic values of drug resistance-related genes in the lung cancer microenvironment.,2022,10.21037/tcr-21-1841,https://pubmed.ncbi.nlm.nih.gov/35281414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC73,ENSG00000186714,Neither,32596394,Identification of an Individualized Prognostic Signature Based on the RWSR Model in Early-Stage Bladder Carcinoma.,2020,10.1155/2020/9186546,https://pubmed.ncbi.nlm.nih.gov/32596394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,41169243,Perinuclear theca protein FNDC8 interacts with CCIN and ACTL7A to ensure proper sperm head shaping during spermiogenesis.,2025,10.24272/j.issn.2095-8137.2025.060,https://pubmed.ncbi.nlm.nih.gov/41169243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,40186177,Exome-wide association study reveals 7 functional variants associated with ex-vivo drug response in acute myeloid leukemia patients.,2025,10.1186/s12920-025-02130-7,https://pubmed.ncbi.nlm.nih.gov/40186177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,37670815,Transcriptomic signatures for human male infertility.,2023,10.3389/fmolb.2023.1226829,https://pubmed.ncbi.nlm.nih.gov/37670815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,36546111,Mutations in CCIN cause teratozoospermia and male infertility.,2022,10.1016/j.scib.2022.09.026,https://pubmed.ncbi.nlm.nih.gov/36546111/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,31470030,Strategies to generate functionally normal neutrophils to reduce infection and infection-related mortality in cancer chemotherapy.,2019,10.1016/j.pharmthera.2019.107403,https://pubmed.ncbi.nlm.nih.gov/31470030/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,33421903,Saikosaponin a contributed to CCIN treatment by promoting neutrophil bactericidal activity via activation CBL-dependent ERK pathway.,2021,10.1016/j.phymed.2020.153444,https://pubmed.ncbi.nlm.nih.gov/33421903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,36047070,Globozoospermia: A Case Report and Systematic Review of Literature.,2023,10.5534/wjmh.220020,https://pubmed.ncbi.nlm.nih.gov/36047070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,34884692,Effect of 2-Cys Peroxiredoxins Inhibition on Redox Modifications of Bull Sperm Proteins.,2021,10.3390/ijms222312888,https://pubmed.ncbi.nlm.nih.gov/34884692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,32822868,Saikosaponin d contributed to cancer chemotherapy induced neutropenia therapy by promoting neutrophil differentiation via activation CBL-dependent ERK pathway.,2020,10.1016/j.phrs.2020.105149,https://pubmed.ncbi.nlm.nih.gov/32822868/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,32582379,Identification of a novel deletion mutation in DPY19L2 from an infertile patient with globozoospermia: a case report.,2020,10.1186/s13039-020-00495-1,https://pubmed.ncbi.nlm.nih.gov/32582379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,31985809,Exome sequencing reveals novel causes as well as new candidate genes for human globozoospermia.,2020,10.1093/humrep/dez246,https://pubmed.ncbi.nlm.nih.gov/31985809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,35793634,The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice.,2022,10.1016/j.celrep.2022.111049,https://pubmed.ncbi.nlm.nih.gov/35793634/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,27737899,Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality.,2016,10.15252/emmm.201606434,https://pubmed.ncbi.nlm.nih.gov/27737899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,36896575,The human sperm proteome-Toward a panel for male fertility testing.,2023,10.1111/andr.13431,https://pubmed.ncbi.nlm.nih.gov/36896575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,35654582,FSIP2 plays a role in the acrosome development during spermiogenesis.,2023,10.1136/jmedgenet-2021-108406,https://pubmed.ncbi.nlm.nih.gov/35654582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,30584989,Embryos derived from couples with consanguineous marriages with globozoospermia should be screened for gender or DPY19L2 deletion.,2019,10.1111/and.13221,https://pubmed.ncbi.nlm.nih.gov/30584989/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,21507486,Diagnosis and management of conjunctival and corneal intraepithelial neoplasia using ultra high-resolution optical coherence tomography.,2011,10.1016/j.ophtha.2011.01.005,https://pubmed.ncbi.nlm.nih.gov/21507486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,18753052,[Adsorption and sustained release of epirubicin from carbon-coated iron nanocrystals].,2008,,https://pubmed.ncbi.nlm.nih.gov/18753052/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,21099419,Conjunctival-corneal intraepithelial neoplasia (Bowen disease) treated with orthovoltage.,2011,10.1097/ico.0b013e3181dc816a,https://pubmed.ncbi.nlm.nih.gov/21099419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,39001910,Differences in severity of chemotherapy-induced nausea and vomiting between neoadjuvant and adjuvant chemotherapy in patients with breast cancer: analysis of data from two prospective observational studies.,2024,10.1007/s00520-024-08718-6,https://pubmed.ncbi.nlm.nih.gov/39001910/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,18250036,[Effects of carbon-coated iron nanocrystals combined with epirubicin on HepG-2 cells and its acute toxicity in mice].,2008,,https://pubmed.ncbi.nlm.nih.gov/18250036/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,17959516,[Acute toxicity of carbon-coated iron nanocrystal and its effect on liver and kidney functions and hematological system].,2007,,https://pubmed.ncbi.nlm.nih.gov/17959516/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,20447963,Treatment of ocular surface squamous neoplasia with Mitomycin C.,2010,10.1136/bjo.2009.168294,https://pubmed.ncbi.nlm.nih.gov/20447963/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,19617789,Long-term results of topical mitomycin C 0.02% for primary and recurrent conjunctival-corneal intraepithelial neoplasia.,2009,10.1097/iop.0b013e3181ac4c39,https://pubmed.ncbi.nlm.nih.gov/19617789/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,12352093,Mitomycin C therapy for conjunctival-corneal intraepithelial neoplasia.,2002,10.1097/00003226-200210000-00017,https://pubmed.ncbi.nlm.nih.gov/12352093/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,9400769,Mitomycin C treatment for conjunctival-corneal intraepithelial neoplasia: a multicenter experience.,1997,10.1016/s0161-6420(97)30055-4,https://pubmed.ncbi.nlm.nih.gov/9400769/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCIN,ENSG00000185972,Neither,36527329,Novel homozygous variant of CCIN causes male infertility owing to the abnormal sperm head with a nuclear subsidence phenotype.,2023,10.1111/cge.14281,https://pubmed.ncbi.nlm.nih.gov/36527329/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,42693845,CDC20B Dysregulation: Links to Tumor Prognosis and Immunity.,2026,10.2174/0109298673463433260729044815,https://pubmed.ncbi.nlm.nih.gov/42693845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,42272657,Case Report: Cutaneous niche-restricted malignant phenotypes in PTCL-NOS revealed by single-cell sequencing.,2026,10.3389/fonc.2026.1827539,https://pubmed.ncbi.nlm.nih.gov/42272657/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,42032036,Hypoxic CA9 variant as a potential prognostic marker in gastric and breast cancers.,2026,10.1038/s41598-026-49972-4,https://pubmed.ncbi.nlm.nih.gov/42032036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,41610616,Shell gland RNA-seq reveals key genes regulating eggshell quality and potential links between eggshell quality and hatchability across different laying stages.,2026,10.1016/j.psj.2026.106483,https://pubmed.ncbi.nlm.nih.gov/41610616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,35212610,"Circular RNA hsa_circ_0008896 accelerates atherosclerosis by promoting the proliferation, migration and invasion of vascular smooth muscle cells via hsa-miR-633/CDC20B (cell division cycle 20B) axis.",2022,10.1080/21655979.2022.2039467,https://pubmed.ncbi.nlm.nih.gov/35212610/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,37415453,The genomic landscape associated with resistance to aromatase inhibitors in breast cancer.,2023,10.5808/gi.23012,https://pubmed.ncbi.nlm.nih.gov/37415453/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,35910807,Recapitulating influenza virus infection and facilitating antiviral and neuroprotective screening in tractable brain organoids.,2022,10.7150/thno.75123,https://pubmed.ncbi.nlm.nih.gov/35910807/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,30405130,CDC20B is required for deuterosome-mediated centriole production in multiciliated cells.,2018,10.1038/s41467-018-06768-z,https://pubmed.ncbi.nlm.nih.gov/30405130/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,32575462,"Uncovering Potential Roles of Differentially Expressed Genes, Upstream Regulators, and Canonical Pathways in Endometriosis Using an In Silico Genomics Approach.",2020,10.3390/diagnostics10060416,https://pubmed.ncbi.nlm.nih.gov/32575462/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,31558434,Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures.,2019,10.1242/dev.177428,https://pubmed.ncbi.nlm.nih.gov/31558434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,34959580,Differential Expression of Mitosis and Cell Cycle Regulatory Genes during Recovery from an Acute Respiratory Virus Infection.,2021,10.3390/pathogens10121625,https://pubmed.ncbi.nlm.nih.gov/34959580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,32963610,A prognosis-predictive nomogram of ovarian cancer with two immune-related genes: CDC20B and PNPLA5.,2020,10.3892/ol.2020.12067,https://pubmed.ncbi.nlm.nih.gov/32963610/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,36128756,Effect of forsythoside A on the transcriptional profile of bovine mammary epithelial cells challenged with lipoteichoic acid.,2023,10.1111/rda.14265,https://pubmed.ncbi.nlm.nih.gov/36128756/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,36883528,IL-4 drastically decreases deuterosomal and multiciliated cells via alteration in progenitor cell differentiation.,2023,10.1111/all.15705,https://pubmed.ncbi.nlm.nih.gov/36883528/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,36126549,Development of human retinal organoid models for bisphenol toxicity assessment.,2022,10.1016/j.ecoenv.2022.114094,https://pubmed.ncbi.nlm.nih.gov/36126549/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,27184529,Histone deacetylase inhibition regulates miR-449a levels in skeletal muscle cells.,2016,10.1080/15592294.2016.1188247,https://pubmed.ncbi.nlm.nih.gov/27184529/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,32041280,A Network-Based Bioinformatics Approach to Identify Molecular Biomarkers for Type 2 Diabetes that Are Linked to the Progression of Neurological Diseases.,2020,10.3390/ijerph17031035,https://pubmed.ncbi.nlm.nih.gov/32041280/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,31345231,"miR-449a regulates insulin signalling by targeting the Notch ligand, Jag1 in skeletal muscle cells.",2019,10.1186/s12964-019-0394-7,https://pubmed.ncbi.nlm.nih.gov/31345231/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,25767377,"Antitumor activity of SA12, a novel peptide, on SKBr-3 breast cancer cells via the mitochondrial apoptosis pathway.",2015,10.2147/dddt.s75780,https://pubmed.ncbi.nlm.nih.gov/25767377/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,25437332,"A 3'UTR-associated RNA, FLJ11812 maintains stemness of human embryonic stem cells by targeting miR-4459.",2015,10.1089/scd.2014.0353,https://pubmed.ncbi.nlm.nih.gov/25437332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC20B,ENSG00000164287,Neither,19960022,E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis.,2010,10.1038/cdd.2009.188,https://pubmed.ncbi.nlm.nih.gov/19960022/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL4,ENSG00000205111,Neither,40775720,Investigation of growth traits in Turkish Merino lambs using multi-locus GWAS approaches: Karacabey Merino.,2025,10.1186/s12917-025-04957-9,https://pubmed.ncbi.nlm.nih.gov/40775720/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL4,ENSG00000205111,Neither,29529077,Brain region-specific expression of genes mapped within quantitative trait loci for behavioral responsiveness to acute stress in Fisher 344 and Wistar Kyoto male rats.,2018,10.1371/journal.pone.0194293,https://pubmed.ncbi.nlm.nih.gov/29529077/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL4,ENSG00000205111,Neither,25904054,High-throughput RNAi screening of human kinases identifies predictors of clinical outcome in colorectal cancer patients treated with oxaliplatin.,2015,10.18632/oncotarget.3736,https://pubmed.ncbi.nlm.nih.gov/25904054/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDRT15,ENSG00000223510,Neither,37543771,Bioinformatic analysis the expression and clinical significance of CDRT15 in cholangiocarcinoma using TCGA database.,2023,10.1097/md.0000000000034602,https://pubmed.ncbi.nlm.nih.gov/37543771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDRT15,ENSG00000223510,Neither,11381029,The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes.,2001,10.1101/gr.180401,https://pubmed.ncbi.nlm.nih.gov/11381029/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,35358715,Y-chromosome genes associated with sertoli cell-only syndrome identified by array comparative genome hybridization.,2023,10.1016/j.bj.2022.03.009,https://pubmed.ncbi.nlm.nih.gov/35358715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,34977573,Target identification of mouse stem cell probe CDy1 as ALDH2 and Abcb1b through live-cell affinity-matrix and ABC CRISPRa library.,2021,10.1039/d1cb00147g,https://pubmed.ncbi.nlm.nih.gov/34977573/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,39358566,Comprehensive analysis of chromosomal breakpoints and candidate genes associated with male infertility: insights from cytogenetic studies and expression analyses.,2024,10.1007/s00335-024-10074-z,https://pubmed.ncbi.nlm.nih.gov/39358566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,27525321,Expression level of chromodomain Y (CDY): potential marker for prediction of sperm recovery in non-obstructive azoospermia.,2016,10.29252/ijrm.14.6.383,https://pubmed.ncbi.nlm.nih.gov/27525321/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,33766143,Human AZFb deletions cause distinct testicular pathologies depending on their extensions in Yq11 and the Y haplogroup: new cases and review of literature.,2021,10.1186/s13578-021-00551-2,https://pubmed.ncbi.nlm.nih.gov/33766143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,33850773,Y chromosome copy number variation and its effects on fertility and other health factors: a review.,2021,10.21037/tau.2020.04.06,https://pubmed.ncbi.nlm.nih.gov/33850773/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,32470319,Structural Basis for the Binding Selectivity of Human CDY Chromodomains.,2020,10.1016/j.chembiol.2020.05.007,https://pubmed.ncbi.nlm.nih.gov/32470319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,36317206,[A multiplex PCR-based sensitive and specific method for detecting Y chromosome material in patients with Turner syndrome].,2022,10.3760/cma.j.cn511374-20211209-00978,https://pubmed.ncbi.nlm.nih.gov/36317206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,26162009,Isoform-Level Gene Expression Profiles of Human Y Chromosome Azoospermia Factor Genes and Their X Chromosome Paralogs in the Testicular Tissue of Non-Obstructive Azoospermia Patients.,2015,10.1021/acs.jproteome.5b00520,https://pubmed.ncbi.nlm.nih.gov/26162009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,27725957,Photodynamic Approach for Teratoma-Free Pluripotent Stem Cell Therapy Using CDy1 and Visible Light.,2016,10.1021/acscentsci.6b00099,https://pubmed.ncbi.nlm.nih.gov/27725957/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,26995389,Distinctive pattern of expression of spermatogenic molecular markers in testes of azoospermic men with non-mosaic Klinefelter syndrome.,2016,10.1007/s10815-016-0698-0,https://pubmed.ncbi.nlm.nih.gov/26995389/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,26607720,Enrichment of Mouse Spermatogonial Stem Cells by the Stem Cell Dye CDy1.,2016,10.1095/biolreprod.115.135707,https://pubmed.ncbi.nlm.nih.gov/26607720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,27457284,gr/gr-DAZ2-DAZ4-CDY1b deletion is a high-risk factor for male infertility in Tunisian population.,2016,10.1016/j.gene.2016.07.050,https://pubmed.ncbi.nlm.nih.gov/27457284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,21474125,CDY1 and BOULE transcripts assessed in the same biopsy as predictive markers for successful testicular sperm retrieval.,2011,10.1016/j.fertnstert.2011.03.020,https://pubmed.ncbi.nlm.nih.gov/21474125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,33034826,Partial-AZFc deletions in Chilean men with primary spermatogenic impairment: gene dosage and Y-chromosome haplogroups.,2020,10.1007/s10815-020-01957-6,https://pubmed.ncbi.nlm.nih.gov/33034826/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,23517283,A novel fluorescent reporter CDy1 enriches for neural stem cells derived from the murine brain.,2013,10.1089/scd.2012.0660,https://pubmed.ncbi.nlm.nih.gov/23517283/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,26149076,Susceptibility of gr/gr rearrangements to azoospermia or oligozoospermia is dependent on DAZ and CDY1 gene copy deletions.,2015,10.1007/s10815-015-0520-4,https://pubmed.ncbi.nlm.nih.gov/26149076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,30787516,Examination of Y-Chromosomal Microdeletions and Partial Microdeletions in Idiopathic Infertility in East Hungarian Patients.,2018,10.4103/jhrs.jhrs_12_18,https://pubmed.ncbi.nlm.nih.gov/30787516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,23475625,Identification of an ABCB1 (P-glycoprotein)-positive carfilzomib-resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1.,2013,10.1002/ajh.23387,https://pubmed.ncbi.nlm.nih.gov/23475625/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,15520406,"Sequence family variant loss from the AZFc interval of the human Y chromosome, but not gene copy loss, is strongly associated with male infertility.",2004,10.1136/jmg.2004.022111,https://pubmed.ncbi.nlm.nih.gov/15520406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,25716801,Induced pluripotent stem cells as a model for diabetes investigation.,2015,10.1038/srep08597,https://pubmed.ncbi.nlm.nih.gov/25716801/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,11163833,Expression of CDY1 may identify complete spermatogenesis.,2001,10.1016/s0015-0282(00)01639-3,https://pubmed.ncbi.nlm.nih.gov/11163833/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1,ENSG00000172288,Neither,12072557,Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis.,2002,10.1073/pnas.082248899,https://pubmed.ncbi.nlm.nih.gov/12072557/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1B,ENSG00000172352,Neither,35358715,Y-chromosome genes associated with sertoli cell-only syndrome identified by array comparative genome hybridization.,2023,10.1016/j.bj.2022.03.009,https://pubmed.ncbi.nlm.nih.gov/35358715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1B,ENSG00000172352,Neither,27457284,gr/gr-DAZ2-DAZ4-CDY1b deletion is a high-risk factor for male infertility in Tunisian population.,2016,10.1016/j.gene.2016.07.050,https://pubmed.ncbi.nlm.nih.gov/27457284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1B,ENSG00000172352,Neither,20039973,Differential effect of specific gr/gr deletion subtypes on spermatogenesis in the Chinese Han population.,2010,10.1111/j.1365-2605.2009.01015.x,https://pubmed.ncbi.nlm.nih.gov/20039973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1B,ENSG00000172352,Neither,15520406,"Sequence family variant loss from the AZFc interval of the human Y chromosome, but not gene copy loss, is strongly associated with male infertility.",2004,10.1136/jmg.2004.022111,https://pubmed.ncbi.nlm.nih.gov/15520406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1B,ENSG00000172352,Neither,19088127,The b2/b3 subdeletion shows higher risk of spermatogenic failure and higher frequency of complete AZFc deletion than the gr/gr subdeletion in a Chinese population.,2009,10.1093/hmg/ddn427,https://pubmed.ncbi.nlm.nih.gov/19088127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDY1B,ENSG00000172352,Neither,12072557,Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis.,2002,10.1073/pnas.082248899,https://pubmed.ncbi.nlm.nih.gov/12072557/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP295NL,ENSG00000178404,Neither,40692573,Assessing the Impact of Neuromuscular Taping on Thrombocyte Indices in Diabetic Neuropathy Patients With Peripheral Artery Disease: A Cross-Sectional Study.,2025,10.1002/hsr2.70919,https://pubmed.ncbi.nlm.nih.gov/40692573/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP295NL,ENSG00000178404,Neither,36355624,IQUB deficiency causes male infertility by affecting the activity of p-ERK1/2/RSPH3.,2023,10.1093/humrep/deac244,https://pubmed.ncbi.nlm.nih.gov/36355624/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB2,ENSG00000104818,Neither,32957442,The Study of the Expression of CGB1 and CGB2 in Human Cancer Tissues.,2020,10.3390/genes11091082,https://pubmed.ncbi.nlm.nih.gov/32957442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB2,ENSG00000104818,Neither,31362717,Regulation of human chorionic gonadotropin beta subunit expression in ovarian cancer.,2019,10.1186/s12885-019-5960-2,https://pubmed.ncbi.nlm.nih.gov/31362717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB2,ENSG00000104818,Neither,23774837,Human chorionic gonadotropin beta subunit genes CGB1 and CGB2 are transcriptionally active in ovarian cancer.,2013,10.3390/ijms140612650,https://pubmed.ncbi.nlm.nih.gov/23774837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB2,ENSG00000104818,Neither,29058301,Cancer-Testis Antigens as New Candidate Diagnostic Biomarkers for Transitional Cell Carcinoma of Bladder.,2019,10.1007/s12253-017-0313-4,https://pubmed.ncbi.nlm.nih.gov/29058301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB2,ENSG00000104818,Neither,18048458,Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues.,2008,10.1093/molehr/gam082,https://pubmed.ncbi.nlm.nih.gov/18048458/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB2,ENSG00000104818,Neither,16123088,Expression of beta-subunit of HCG genes during normal and failed pregnancy.,2005,10.1093/humrep/dei261,https://pubmed.ncbi.nlm.nih.gov/16123088/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB2,ENSG00000104818,Neither,17055150,The evolution and genomic landscape of CGB1 and CGB2 genes.,2007,10.1016/j.mce.2005.11.049,https://pubmed.ncbi.nlm.nih.gov/17055150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB2,ENSG00000104818,Neither,24778026,Novel insights into the expression of CGB1 & 2 genes by epithelial cancer cell lines secreting ectopic free hCGβ.,2014,,https://pubmed.ncbi.nlm.nih.gov/24778026/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB2,ENSG00000104818,Neither,25570081,A hybrid dynamic Bayesian network approach for modelling temporal associations of gene expressions for hypertension diagnosis.,2014,10.1109/embc.2014.6943713,https://pubmed.ncbi.nlm.nih.gov/25570081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,42427029,Rescue of stereocilia architecture and hearing function by AAV-CIB2 and AAV-CIB3 in a mouse model of recessive deafness DFNB48.,2026,10.1016/j.ymthe.2026.06.041,https://pubmed.ncbi.nlm.nih.gov/42427029/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,40076845,The Diverse Functions of the Calcium- and Integrin-Binding Protein Family.,2025,10.3390/ijms26052223,https://pubmed.ncbi.nlm.nih.gov/40076845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,40313552,Extreme temperatures modulate gene expression in the airway epithelium of the lungs in mice and asthma patients.,2025,10.3389/fmed.2025.1531154,https://pubmed.ncbi.nlm.nih.gov/40313552/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,39773557,Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels.,2025,10.7554/elife.89719,https://pubmed.ncbi.nlm.nih.gov/39773557/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,37001993,CIB2 and CIB3 Regulate Stereocilia Maintenance and Mechanoelectrical Transduction in Mouse Vestibular Hair Cells.,2023,10.1523/jneurosci.1807-22.2023,https://pubmed.ncbi.nlm.nih.gov/37001993/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,40004470,"Differentially Expressed Genes in Cardiomyocytes of the First Camelized Mouse Model, Nrap&lt;sup&gt;c.255ins78&lt;/sup&gt; Mouse.",2025,10.3390/genes16020142,https://pubmed.ncbi.nlm.nih.gov/40004470/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,39112778,A meta-analysis of genome-wide studies of resilience in the German population.,2025,10.1038/s41380-024-02688-1,https://pubmed.ncbi.nlm.nih.gov/39112778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,34089643,CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells.,2021,10.1016/j.neuron.2021.05.007,https://pubmed.ncbi.nlm.nih.gov/34089643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,39245735,An open-source tool for automated human-level circling behavior detection.,2024,10.1038/s41598-024-71665-z,https://pubmed.ncbi.nlm.nih.gov/39245735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,40000792,Structural insights into calcium-dependent CIB2-TMC1 interaction in hair cell mechanotransduction.,2025,10.1038/s42003-025-07761-1,https://pubmed.ncbi.nlm.nih.gov/40000792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,32430498,CIB4 is essential for the haploid phase of spermatogenesis in mice†.,2020,10.1093/biolre/ioaa059,https://pubmed.ncbi.nlm.nih.gov/32430498/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,38035267,Differential expression of mechanotransduction complex genes in auditory/vestibular hair cells in zebrafish.,2023,10.3389/fnmol.2023.1274822,https://pubmed.ncbi.nlm.nih.gov/38035267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,28902924,Molecular analysis of CIB4 gene and protein in Kermani sheep.,2017,10.1590/1414-431x20176177,https://pubmed.ncbi.nlm.nih.gov/28902924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,37556230,Evidence of kinesin motors involved in stable kinetochore assembly during early meiosis.,2023,10.1091/mbc.e22-12-0569,https://pubmed.ncbi.nlm.nih.gov/37556230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,33752231,Microtubule-associated proteins and motors required for ectopic microtubule array formation in Saccharomyces cerevisiae.,2021,10.1093/genetics/iyab050,https://pubmed.ncbi.nlm.nih.gov/33752231/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,35791811,Reconstitution of kinetochore motility and microtubule dynamics reveals a role for a kinesin-8 in establishing end-on attachments.,2022,10.7554/elife.78450,https://pubmed.ncbi.nlm.nih.gov/35791811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,33850247,A model of processive walking and slipping of kinesin-8 molecular motors.,2021,10.1038/s41598-021-87532-0,https://pubmed.ncbi.nlm.nih.gov/33850247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,31964755,Meiosis-Specific Functions of Kinesin Motors in Cohesin Removal and Maintenance of Chromosome Integrity in Budding Yeast.,2020,10.1128/mcb.00386-19,https://pubmed.ncbi.nlm.nih.gov/31964755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,30360926,Three-Dimensional Optical Tweezers Tracking Resolves Random Sideward Steps of the Kinesin-8 Kip3.,2018,10.1016/j.bpj.2018.09.026,https://pubmed.ncbi.nlm.nih.gov/30360926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,36645568,Determinant factors for residence time of kinesin motors at microtubule ends.,2023,10.1007/s10867-022-09623-x,https://pubmed.ncbi.nlm.nih.gov/36645568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,32229316,The Kinesin-8 Kip3 Depolymerizes Microtubules with a Collective Force-Dependent Mechanism.,2020,10.1016/j.bpj.2020.02.030,https://pubmed.ncbi.nlm.nih.gov/32229316/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,34631345,A proteomic analysis of Pseudevernia furfuracea after exposure to Cr+6 by MALDI-TOF mass spectrometry.,2021,10.1007/s13205-021-02986-3,https://pubmed.ncbi.nlm.nih.gov/34631345/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,20647749,Kip3-ing kinetochores clustered.,2010,10.4161/cc.9.13.12274,https://pubmed.ncbi.nlm.nih.gov/20647749/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB3,ENSG00000141977,Neither,23746518,Kinesin-8 is a low-force motor protein with a weakly bound slip state.,2013,10.1016/j.bpj.2013.02.040,https://pubmed.ncbi.nlm.nih.gov/23746518/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB4,ENSG00000157884,Neither,40398143,Decreased expressions of calcium- and integrin-binding protein 4 in the testes of patients with azoosperma and in the ejaculated spermatozoa of patients with abnormal semen parameters.,2025,10.1016/j.ejogrb.2025.114045,https://pubmed.ncbi.nlm.nih.gov/40398143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB4,ENSG00000157884,Neither,40076845,The Diverse Functions of the Calcium- and Integrin-Binding Protein Family.,2025,10.3390/ijms26052223,https://pubmed.ncbi.nlm.nih.gov/40076845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB4,ENSG00000157884,Neither,32430498,CIB4 is essential for the haploid phase of spermatogenesis in mice†.,2020,10.1093/biolre/ioaa059,https://pubmed.ncbi.nlm.nih.gov/32430498/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB4,ENSG00000157884,Neither,40020829,Whole-exome sequencing identifies EP300 variants associated with visceral leishmaniasis relapse.,2025,10.1016/j.ijbiomac.2025.141533,https://pubmed.ncbi.nlm.nih.gov/40020829/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB4,ENSG00000157884,Neither,28902924,Molecular analysis of CIB4 gene and protein in Kermani sheep.,2017,10.1590/1414-431x20176177,https://pubmed.ncbi.nlm.nih.gov/28902924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB4,ENSG00000157884,Neither,35145544,Identification of Key Genes Related to Postnatal Testicular Development Based on Transcriptomic Data of Testis in Hu Sheep.,2021,10.3389/fgene.2021.773695,https://pubmed.ncbi.nlm.nih.gov/35145544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB4,ENSG00000157884,Neither,31198943,Epigenetic regulation of miR396 expression by SWR1-C and the effect of miR396 on leaf growth and developmental phase transition in Arabidopsis.,2019,10.1093/jxb/erz285,https://pubmed.ncbi.nlm.nih.gov/31198943/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB4,ENSG00000157884,Neither,20236775,Alternative splicing and tissue expression of CIB4 gene in sheep testis.,2010,10.1016/j.anireprosci.2010.01.004,https://pubmed.ncbi.nlm.nih.gov/20236775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB4,ENSG00000157884,Neither,29255404,Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice.,2017,10.3389/fnmol.2017.00401,https://pubmed.ncbi.nlm.nih.gov/29255404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB4,ENSG00000157884,Neither,18989754,Molecular characterization of the sheep CIB1 gene.,2009,10.1007/s11033-008-9383-4,https://pubmed.ncbi.nlm.nih.gov/18989754/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIB4,ENSG00000157884,Neither,24130508,Multiple bHLH proteins form heterodimers to mediate CRY2-dependent regulation of flowering-time in Arabidopsis.,2013,10.1371/journal.pgen.1003861,https://pubmed.ncbi.nlm.nih.gov/24130508/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN2,ENSG00000249581,Neither,41572507,Compensatory Interplay Between Clarin-1 and Clarin-2 Deafness-Associated Proteins Governs Phenotypic Variability in Hearing.,2026,10.1002/advs.202521853,https://pubmed.ncbi.nlm.nih.gov/41572507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN2,ENSG00000249581,Neither,38243601,Clarin-2 gene supplementation durably preserves hearing in a model of progressive hearing loss.,2024,10.1016/j.ymthe.2024.01.021,https://pubmed.ncbi.nlm.nih.gov/38243601/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN2,ENSG00000249581,Neither,39446282,A novel CLRN2 variant: expanding the mutation spectrum and its critical role in isolated hearing impairment.,2025,10.1007/s13258-024-01590-y,https://pubmed.ncbi.nlm.nih.gov/39446282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN2,ENSG00000249581,Neither,40561828,A significant genomic region underlying growth traits in adult Beijing You chicken identified by genome-wide association analysis.,2025,10.1016/j.psj.2025.105326,https://pubmed.ncbi.nlm.nih.gov/40561828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN2,ENSG00000249581,Neither,33496845,A biallelic variant in CLRN2 causes non-syndromic hearing loss in humans.,2021,10.1007/s00439-020-02254-z,https://pubmed.ncbi.nlm.nih.gov/33496845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN2,ENSG00000249581,Neither,31448880,Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.,2019,10.15252/emmm.201910288,https://pubmed.ncbi.nlm.nih.gov/31448880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN2,ENSG00000249581,Neither,31564434,GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty in UK Biobank.,2019,10.1016/j.ajhg.2019.09.008,https://pubmed.ncbi.nlm.nih.gov/31564434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,41131016,"Structural mechanisms of assembly, gating, and calmodulin modulation of human olfactory CNG channel.",2025,10.1038/s41467-025-64436-5,https://pubmed.ncbi.nlm.nih.gov/41131016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,42353812,Molecular Evidence for the Parallel Evolution of Anosmia in Multiple Odontoceti (Toothed Whales) Clades.,2026,10.3390/genes17060651,https://pubmed.ncbi.nlm.nih.gov/42353812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,39844350,Signal Transduction Pathway Mediating Carotid Body Dependent Sympathetic Activation and Hypertension by Chronic Intermittent Hypoxia.,2025,10.1093/function/zqaf003,https://pubmed.ncbi.nlm.nih.gov/39844350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,37406126,Hypoxia sensing requires H&lt;sub&gt;2&lt;/sub&gt;S-dependent persulfidation of olfactory receptor 78.,2023,10.1126/sciadv.adf3026,https://pubmed.ncbi.nlm.nih.gov/37406126/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,36584299,Unusual phototransduction via cross-motif signaling from Gq to adenylyl cyclase in intrinsically photosensitive retinalganglion cells.,2023,10.1073/pnas.2216599120,https://pubmed.ncbi.nlm.nih.gov/36584299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,38148624,Identifying candidate genes underlying isolated congenital anosmia.,2024,10.1111/cge.14470,https://pubmed.ncbi.nlm.nih.gov/38148624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,36330924,Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction.,2022,10.1016/j.pneurobio.2022.102369,https://pubmed.ncbi.nlm.nih.gov/36330924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,32272140,Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1.,2020,10.1016/j.neuropharm.2020.108087,https://pubmed.ncbi.nlm.nih.gov/32272140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,28572688,Isolated Congenital Anosmia and CNGA2 Mutation.,2017,10.1038/s41598-017-02947-y,https://pubmed.ncbi.nlm.nih.gov/28572688/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,36584110,Ancient multiplicity in cyclic nucleotide-gated (CNG) cation channel repertoire was reduced in the ancestor of Olfactores before re-expansion by whole genome duplications in vertebrates.,2022,10.1371/journal.pone.0279548,https://pubmed.ncbi.nlm.nih.gov/36584110/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,35998156,Subunit promotion energies for channel opening in heterotetrameric olfactory CNG channels.,2022,10.1371/journal.pcbi.1010376,https://pubmed.ncbi.nlm.nih.gov/35998156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,34311839,[Evaluation of proficiency test with low number of participants:a case study on the testing of lead and nitrite in water].,2021,10.19813/j.cnki.weishengyanjiu.2021.04.019,https://pubmed.ncbi.nlm.nih.gov/34311839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,30294598,Genome Editing Reveals Idiosyncrasy of CNGA2 Ion Channel-Directed Antibody Immunoreactivity Toward Oxytocin.,2018,10.3389/fcell.2018.00117,https://pubmed.ncbi.nlm.nih.gov/30294598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,25156905,The first mutation in CNGA2 in two brothers with anosmia.,2015,10.1111/cge.12491,https://pubmed.ncbi.nlm.nih.gov/25156905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,31130235,Novel Fluorescent Cyclic Nucleotide Derivatives to Study CNG and HCN Channel Function.,2019,10.1016/j.bpj.2019.05.006,https://pubmed.ncbi.nlm.nih.gov/31130235/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,32727968,Distribution of cells expressing vomeronasal receptors in the olfactory organ of turtles.,2020,10.1292/jvms.20-0207,https://pubmed.ncbi.nlm.nih.gov/32727968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,30297855,Hydrophobic alkyl chains substituted to the 8-position of cyclic nucleotides enhance activation of CNG and HCN channels by an intricate enthalpy - entropy compensation.,2018,10.1038/s41598-018-33050-5,https://pubmed.ncbi.nlm.nih.gov/30297855/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,30233329,P/Q Type Calcium Channel Cav2.1 Defines a Unique Subset of Glomeruli in the Mouse Olfactory Bulb.,2018,10.3389/fncel.2018.00295,https://pubmed.ncbi.nlm.nih.gov/30233329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,28097125,Bioinformatics Analysis of the Human Surfaceome Reveals New Targets for a Variety of Tumor Types.,2016,10.1155/2016/8346198,https://pubmed.ncbi.nlm.nih.gov/28097125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,23126335,Visualization of odor-induced neuronal activity by immediate early gene expression.,2012,10.1186/1471-2202-13-140,https://pubmed.ncbi.nlm.nih.gov/23126335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,40874467,A Degradable Bioinspired Flier with Aerogel-Based Colorimetric Sensors for Environmental Monitoring.,2026,10.1002/advs.202508949,https://pubmed.ncbi.nlm.nih.gov/40874467/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,25192635,Anxiety- and depressive-like behaviors in olfactory deficient Cnga2 knockout mice.,2014,10.1016/j.bbr.2014.08.042,https://pubmed.ncbi.nlm.nih.gov/25192635/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,26007191,Cellular Structural Changes in Candida albicans Caused by the Hydroalcoholic Extract from Sapindus saponaria L.,2015,10.3390/molecules20059405,https://pubmed.ncbi.nlm.nih.gov/26007191/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,24695705,Postnatal odorant exposure induces peripheral olfactory plasticity at the cellular level.,2014,10.1523/jneurosci.0688-13.2014,https://pubmed.ncbi.nlm.nih.gov/24695705/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,15071119,Odors detected by mice deficient in cyclic nucleotide-gated channel subunit A2 stimulate the main olfactory system.,2004,10.1523/jneurosci.0188-04.2004,https://pubmed.ncbi.nlm.nih.gov/15071119/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNGA2,ENSG00000183862,Neither,12649326,Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice.,2003,10.1073/pnas.0736071100,https://pubmed.ncbi.nlm.nih.gov/12649326/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG1,ENSG00000198930,Neither,42590700,A Dual-Adaptive Sage-Husa Kalman Filter with Model Matching Check for GNSS/INS-Integrated Navigation.,2026,10.3390/s26154925,https://pubmed.ncbi.nlm.nih.gov/42590700/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG1,ENSG00000198930,Neither,40346495,Causal effect of gut microbiota metabolic pathways on CSAG1 expression in chondrosarcoma: a mendelian randomization analysis.,2025,10.1186/s12885-025-14281-y,https://pubmed.ncbi.nlm.nih.gov/40346495/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG1,ENSG00000198930,Neither,32295846,CSAG1 maintains the integrity of the mitotic centrosome in cells with defective p53.,2020,10.1242/jcs.239723,https://pubmed.ncbi.nlm.nih.gov/32295846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG1,ENSG00000198930,Neither,35037484,Selection and validation of reference genes for quantitative real-time PCR in Cymbidium sinense.,2022,10.2144/btn-2021-0073,https://pubmed.ncbi.nlm.nih.gov/35037484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG1,ENSG00000198930,Neither,37800836,Gastric cancer metastasis-related NT5DC2 indicates unfavorable prognosis of patients.,2023,10.1097/md.0000000000035030,https://pubmed.ncbi.nlm.nih.gov/37800836/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG1,ENSG00000198930,Neither,31634526,"Cancer testis antigens in sarcoma: Expression, function and immunotherapeutic application.",2020,10.1016/j.canlet.2019.10.024,https://pubmed.ncbi.nlm.nih.gov/31634526/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG1,ENSG00000198930,Neither,30181888,An AGAMOUS-like factor is associated with the origin of two domesticated varieties in Cymbidium sinense (Orchidaceae).,2018,10.1038/s41438-018-0052-z,https://pubmed.ncbi.nlm.nih.gov/30181888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG1,ENSG00000198930,Neither,38217083,An integrative analysis of GEO data to identify possible therapeutic biomarkers of prostate cancer and targeting potential protein through &lt;i&gt;Zea mays&lt;/i&gt; phytochemicals by virtual screening approaches.,2025,10.1080/07391102.2023.2283163,https://pubmed.ncbi.nlm.nih.gov/38217083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG1,ENSG00000198930,Neither,35142951,Differential gene expression and network analysis in head and neck squamous cell carcinoma.,2022,10.1007/s11010-022-04379-3,https://pubmed.ncbi.nlm.nih.gov/35142951/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG1,ENSG00000198930,Neither,26667017,Chimeric transcripts resulting from complex duplications in chromosome Xq28.,2016,10.1007/s00439-015-1614-x,https://pubmed.ncbi.nlm.nih.gov/26667017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG1,ENSG00000198930,Neither,20726502,A panel of cancer-testis genes exhibiting broad-spectrum expression in haematological malignancies.,2010,,https://pubmed.ncbi.nlm.nih.gov/20726502/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG1,ENSG00000198930,Neither,28800320,An ensemble method integrated with miRNA expression data for predicting miRNA targets in stomach adenocarcinoma.,2017,10.3233/cbm-170595,https://pubmed.ncbi.nlm.nih.gov/28800320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG1,ENSG00000198930,Neither,12039054,Cancer/testis antigen CSAGE is concurrently expressed with MAGE in chondrosarcoma.,2002,10.1016/s0378-1119(02)00395-5,https://pubmed.ncbi.nlm.nih.gov/12039054/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG2,ENSG00000268902,Neither,42899482,Tumour Antigen-Specific Antibody Signatures as Diagnostic Biomarkers for Melanoma.,2026,10.1002/ijc.70726,https://pubmed.ncbi.nlm.nih.gov/42899482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG2,ENSG00000268902,Neither,39003454,Key genes and molecular mechanisms related to Paclitaxel Resistance.,2024,10.1186/s12935-024-03415-0,https://pubmed.ncbi.nlm.nih.gov/39003454/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG2,ENSG00000268902,Neither,32761762,CSAG2 is a cancer-specific activator of SIRT1.,2020,10.15252/embr.202050912,https://pubmed.ncbi.nlm.nih.gov/32761762/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG2,ENSG00000268902,Neither,33519462,CPEB4-Promoted Paclitaxel Resistance in Ovarian Cancer In Vitro Relies on Translational Regulation of CSAG2.,2020,10.3389/fphar.2020.600994,https://pubmed.ncbi.nlm.nih.gov/33519462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG2,ENSG00000268902,Neither,37800836,Gastric cancer metastasis-related NT5DC2 indicates unfavorable prognosis of patients.,2023,10.1097/md.0000000000035030,https://pubmed.ncbi.nlm.nih.gov/37800836/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG2,ENSG00000268902,Neither,30181888,An AGAMOUS-like factor is associated with the origin of two domesticated varieties in Cymbidium sinense (Orchidaceae).,2018,10.1038/s41438-018-0052-z,https://pubmed.ncbi.nlm.nih.gov/30181888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG2,ENSG00000268902,Neither,24021875,Gene expression profiling using nanostring digital RNA counting to identify potential target antigens for melanoma immunotherapy.,2013,10.1158/1078-0432.ccr-13-1253,https://pubmed.ncbi.nlm.nih.gov/24021875/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG2,ENSG00000268902,Neither,25733303,Nanowire analysis of cancer-testis antigens as biomarkers of aggressive prostate cancer.,2015,10.1016/j.urology.2014.12.004,https://pubmed.ncbi.nlm.nih.gov/25733303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG2,ENSG00000268902,Neither,22009167,Cancer-testis antigens expressed in osteosarcoma identified by gene microarray correlate with a poor patient prognosis.,2012,10.1002/cncr.26486,https://pubmed.ncbi.nlm.nih.gov/22009167/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG2,ENSG00000268902,Neither,26372358,Genomic signatures for paclitaxel and gemcitabine resistance in breast cancer derived by machine learning.,2016,10.1016/j.molonc.2015.07.006,https://pubmed.ncbi.nlm.nih.gov/26372358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG2,ENSG00000268902,Neither,17342728,"A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family.",2008,10.1002/mrd.20651,https://pubmed.ncbi.nlm.nih.gov/17342728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG2,ENSG00000268902,Neither,17216190,Taxol-resistance-associated gene-3 (TRAG-3/CSAG2) expression is predictive for clinical outcome in ovarian carcinoma patients.,2007,10.1007/s00428-006-0346-7,https://pubmed.ncbi.nlm.nih.gov/17216190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG2,ENSG00000268902,Neither,17243165,Gene dosage alterations revealed by cDNA microarray analysis in cervical cancer: identification of candidate amplified and overexpressed genes.,2007,10.1002/gcc.20418,https://pubmed.ncbi.nlm.nih.gov/17243165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG3,ENSG00000268916,Neither,35910807,Recapitulating influenza virus infection and facilitating antiviral and neuroprotective screening in tractable brain organoids.,2022,10.7150/thno.75123,https://pubmed.ncbi.nlm.nih.gov/35910807/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG3,ENSG00000268916,Neither,30485425,Targeting the arginine metabolic brake enhances immunotherapy for leukaemia.,2019,10.1002/ijc.32028,https://pubmed.ncbi.nlm.nih.gov/30485425/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG3,ENSG00000268916,Neither,30755830,Identification of special key genes for alcohol-related hepatocellular carcinoma through bioinformatic analysis.,2019,10.7717/peerj.6375,https://pubmed.ncbi.nlm.nih.gov/30755830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG3,ENSG00000268916,Neither,20734393,Upregulation of TRAG3 gene in urothelial carcinoma of the bladder.,2011,10.1002/ijc.25631,https://pubmed.ncbi.nlm.nih.gov/20734393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSAG3,ENSG00000268916,Neither,16331256,Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer.,2006,10.1038/sj.onc.1209279,https://pubmed.ncbi.nlm.nih.gov/16331256/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSNK1A1L,ENSG00000180138,Neither,32765697,A validated miRNA signature for the diagnosis of osteoporosis related fractures using SVM algorithm classification.,2020,10.3892/etm.2020.8928,https://pubmed.ncbi.nlm.nih.gov/32765697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSNK1A1L,ENSG00000180138,Neither,34241534,Multiethnic Genome-Wide Association Study of Subclinical Atherosclerosis in Individuals With Type 2 Diabetes.,2021,10.1161/circgen.120.003258,https://pubmed.ncbi.nlm.nih.gov/34241534/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSNK1A1L,ENSG00000180138,Neither,31232011,"Arotinoid trometamol inhibits arsenic trioxide-stimulated keratinocyte proliferation via the Wnt, Shh, and bone morphogenetic protein signaling pathways.",2019,,https://pubmed.ncbi.nlm.nih.gov/31232011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSNK1A1L,ENSG00000180138,Neither,24096177,Contribution of genetic and epigenetic mechanisms to Wnt pathway activity in prevalent skeletal disorders.,2013,10.1016/j.gene.2013.09.080,https://pubmed.ncbi.nlm.nih.gov/24096177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSNK2A2IP,ENSG00000283434,Neither,32335213,Identification of Novel Targets of RBM5 in the Healthy and Injured Brain.,2020,10.1016/j.neuroscience.2020.04.024,https://pubmed.ncbi.nlm.nih.gov/32335213/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSNK2A2IP,ENSG00000283434,Neither,26771610,Optimizing a Male Reproductive Aging Mouse Model by D-Galactose Injection.,2016,10.3390/ijms17010098,https://pubmed.ncbi.nlm.nih.gov/26771610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,40287105,Toxoplasma cyst wall CST9 elicits an acute-associated humoral response in humans and mice and protects against chronic infection in immunized mice.,2025,10.1016/j.micpath.2025.107638,https://pubmed.ncbi.nlm.nih.gov/40287105/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,36552753,cfDNA Methylation Profiles and T-Cell Differentiation in Women with Endometrial Polyps.,2022,10.3390/cells11243989,https://pubmed.ncbi.nlm.nih.gov/36552753/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,33086656,Effect of Gosha-Jinki-Gan on Levels of Specific mRNA Transcripts in Mouse Testes after Busulfan Treatment.,2020,10.3390/biomedicines8100432,https://pubmed.ncbi.nlm.nih.gov/33086656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,37342358,Decoding the genetic relationship between Alzheimer's disease and type 2 diabetes: potential risk variants and future direction for North Africa.,2023,10.3389/fnagi.2023.1114810,https://pubmed.ncbi.nlm.nih.gov/37342358/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,34899825,Pathway Association Studies Reveal Gene Loci and Pathway Networks that Associated With Plasma Cystatin C Levels.,2021,10.3389/fgene.2021.711155,https://pubmed.ncbi.nlm.nih.gov/34899825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,31346501,Kininogen-1 as a protein biomarker for schizophrenia through mass spectrometry and genetic association analyses.,2019,10.7717/peerj.7327,https://pubmed.ncbi.nlm.nih.gov/31346501/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,35053566,The Role of the Extracellular Matrix and Tumor-Infiltrating Immune Cells in the Prognostication of High-Grade Serous Ovarian Cancer.,2022,10.3390/cancers14020404,https://pubmed.ncbi.nlm.nih.gov/35053566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,35227251,GWAS in people of Middle Eastern descent reveals a locus protective of kidney function-a cross-sectional study.,2022,10.1186/s12916-022-02267-7,https://pubmed.ncbi.nlm.nih.gov/35227251/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,29229643,Cystatins 9 and C as a Novel Immunotherapy Treatment That Protects against Multidrug-Resistant New Delhi Metallo-Beta-Lactamase-1-Producing Klebsiella pneumoniae.,2018,10.1128/aac.01900-17,https://pubmed.ncbi.nlm.nih.gov/29229643/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,34965257,Combined mRNAs and clinical factors model on predicting prognosis in patients with triple-negative breast cancer.,2021,10.1371/journal.pone.0260811,https://pubmed.ncbi.nlm.nih.gov/34965257/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,27645719,Identification of radiation response genes and proteins from mouse pulmonary tissues after high-dose per fraction irradiation of limited lung volumes.,2017,10.1080/09553002.2017.1235297,https://pubmed.ncbi.nlm.nih.gov/27645719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,23922243,Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis.,2013,10.2119/molmed.2013.00081,https://pubmed.ncbi.nlm.nih.gov/23922243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,29582157,"Next-generation sequencing reveals genetic landscape in 46, XY disorders of sexual development patients with variable phenotypes.",2018,10.1007/s00439-018-1879-y,https://pubmed.ncbi.nlm.nih.gov/29582157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,25736290,DNA damage response clamp 9-1-1 promotes assembly of ZMM proteins for formation of crossovers and synaptonemal complex.,2015,10.1242/jcs.161554,https://pubmed.ncbi.nlm.nih.gov/25736290/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,27923845,Numerical and spatial patterning of yeast meiotic DNA breaks by Tel1.,2017,10.1101/gr.213587.116,https://pubmed.ncbi.nlm.nih.gov/27923845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,24717437,Homologue engagement controls meiotic DNA break number and distribution.,2014,10.1038/nature13120,https://pubmed.ncbi.nlm.nih.gov/24717437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,10454593,New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability.,1999,10.1093/nar/27.15.3001,https://pubmed.ncbi.nlm.nih.gov/10454593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,20565543,"Evolution and human tissue expression of the Cres/Testatin subgroup genes, a reproductive tissue specific subgroup of the type 2 cystatins.",2010,10.1111/j.1525-142x.2010.00418.x,https://pubmed.ncbi.nlm.nih.gov/20565543/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CST9,ENSG00000173335,Neither,12535658,"Molecular cloning and characterization of a novel cystatin-like molecule, CLM, from human bone marrow stromal cells.",2003,10.1016/s0006-291x(02)02985-6,https://pubmed.ncbi.nlm.nih.gov/12535658/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSTL1,ENSG00000125823,Neither,40210827,Associations of epigenetic aging and COVID- 19: A 3-year longitudinal study.,2025,10.1007/s11357-025-01635-4,https://pubmed.ncbi.nlm.nih.gov/40210827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSTL1,ENSG00000125823,Neither,35928453,Multi-Omics Analysis of the Tumor Microenvironment in Liver Metastasis of Colorectal Cancer Identified FJX1 as a Novel Biomarker.,2022,10.3389/fgene.2022.960954,https://pubmed.ncbi.nlm.nih.gov/35928453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSTL1,ENSG00000125823,Neither,33578757,Efficient Transformation of Somatic Embryos and Regeneration of Cork Oak Plantlets with A Gene (CsTL1) Encoding a Chestnut Thaumatin-Like Protein.,2021,10.3390/ijms22041757,https://pubmed.ncbi.nlm.nih.gov/33578757/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSTL1,ENSG00000125823,Neither,33791201,Identification of Survival-Associated Gene Signature in Lung Cancer Coexisting With COPD.,2021,10.3389/fonc.2021.600243,https://pubmed.ncbi.nlm.nih.gov/33791201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSTL1,ENSG00000125823,Neither,18391548,The reproductive tissue specific cystatin subgroup of genes: expression during gonadal development in wildtype and testatin knockout animals.,2007,10.1159/000111768,https://pubmed.ncbi.nlm.nih.gov/18391548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSTL1,ENSG00000125823,Neither,23086811,Genetic transformation of European chestnut somatic embryos with a native thaumatin-like protein (CsTL1) gene isolated from Castanea sativa seeds.,2012,10.1093/treephys/tps098,https://pubmed.ncbi.nlm.nih.gov/23086811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSTL1,ENSG00000125823,Neither,20565543,"Evolution and human tissue expression of the Cres/Testatin subgroup genes, a reproductive tissue specific subgroup of the type 2 cystatins.",2010,10.1111/j.1525-142x.2010.00418.x,https://pubmed.ncbi.nlm.nih.gov/20565543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSTL1,ENSG00000125823,Neither,20107207,"Cathepsin B, cathepsin L, and cystatin C in the porcine uterus and placenta: potential roles in endometrial/placental remodeling and in fluid-phase transport of proteins secreted by uterine epithelia across placental areolae.",2010,10.1095/biolreprod.109.080929,https://pubmed.ncbi.nlm.nih.gov/20107207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A8,ENSG00000278085,Neither,15905330,Identification of cancer/testis-antigen genes by massively parallel signature sequencing.,2005,10.1073/pnas.0502583102,https://pubmed.ncbi.nlm.nih.gov/15905330/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A9,ENSG00000270946,Neither,15905330,Identification of cancer/testis-antigen genes by massively parallel signature sequencing.,2005,10.1073/pnas.0502583102,https://pubmed.ncbi.nlm.nih.gov/15905330/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,41469662,Overexpression of cancer testis antigens in gastric cancer and their correlations with the patients' clinicopathological characteristics.,2025,10.1186/s12920-025-02295-1,https://pubmed.ncbi.nlm.nih.gov/41469662/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,42438600,Identification of immunopeptides (pHLA) as candidate therapeutic targets in chondrosarcoma.,2026,10.1016/j.jbo.2026.100780,https://pubmed.ncbi.nlm.nih.gov/42438600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,42289540,Hypoxia-driven transcriptional activation of MIR100HG by HIF-1α contributes to adaptive gene regulation in hepatocellular carcinoma.,2026,10.1007/s10142-026-01899-9,https://pubmed.ncbi.nlm.nih.gov/42289540/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,38733699,Enhancing antitumor response by efficiently generating large-scale TCR-T cells targeting a single epitope across multiple cancer antigens.,2024,10.1016/j.cellimm.2024.104827,https://pubmed.ncbi.nlm.nih.gov/38733699/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,38706911,Decreased Expression of PLD2 Promotes EMT in Colorectal Cancer Invasion and Metastasis.,2024,10.7150/jca.89970,https://pubmed.ncbi.nlm.nih.gov/38706911/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,41087166,Placental transcriptomic profiling showed disturbance of chemokine activities and lymphocyte chemotaxis in pregnancy with fetal growth restriction.,2025,10.1080/14767058.2025.2567473,https://pubmed.ncbi.nlm.nih.gov/41087166/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,38335428,Identification of an 8 HPV-related RNA signature as a novel prognostic biomarker for squamous cell carcinoma of the head and neck.,2024,10.1097/md.0000000000036448,https://pubmed.ncbi.nlm.nih.gov/38335428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,35668458,RAF1 promotes lymphatic metastasis of hypopharyngeal carcinoma via regulating LAGE1: an experimental research.,2022,10.1186/s12967-022-03468-7,https://pubmed.ncbi.nlm.nih.gov/35668458/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,38309723,Comprehensive multiplexed autoantibody profiling of patients with advanced urothelial cancer.,2024,10.1136/jitc-2023-008215,https://pubmed.ncbi.nlm.nih.gov/38309723/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,36761693,Identification of microtubule-associated biomarkers in diffuse large B-cell lymphoma and prognosis prediction.,2022,10.3389/fgene.2022.1092678,https://pubmed.ncbi.nlm.nih.gov/36761693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,31611988,Identification of cancer/testis antigen 2 gene as a potential hepatocellular carcinoma therapeutic target by hub gene screening with topological analysis.,2019,10.3892/ol.2019.10811,https://pubmed.ncbi.nlm.nih.gov/31611988/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,30656409,Expression of cancer-testis antigens in esophageal cancer and their progress in immunotherapy.,2019,10.1007/s00432-019-02840-3,https://pubmed.ncbi.nlm.nih.gov/30656409/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,33921749,Analysis of LAGEs Family Gene Signature and Prognostic Relevance in Breast Cancer.,2021,10.3390/diagnostics11040726,https://pubmed.ncbi.nlm.nih.gov/33921749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,24457462,"Expression of cancer-testis antigens MAGEA1, MAGEA3, ACRBP, PRAME, SSX2, and CTAG2 in myxoid and round cell liposarcoma.",2014,10.1038/modpathol.2013.244,https://pubmed.ncbi.nlm.nih.gov/24457462/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,31432149,Genome‑wide investigation of the clinical implications and molecular mechanism of long noncoding RNA LINC00668 and protein‑coding genes in hepatocellular carcinoma.,2019,10.3892/ijo.2019.4858,https://pubmed.ncbi.nlm.nih.gov/31432149/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,34690620,Implementation of Vaccinomics and In-Silico Approaches to Construct Multimeric Based Vaccine Against Ovarian Cancer.,2021,10.1007/s10989-021-10294-w,https://pubmed.ncbi.nlm.nih.gov/34690620/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,35565356,Multivariant Transcriptome Analysis Identifies Modules and Hub Genes Associated with Poor Outcomes in Newly Diagnosed Multiple Myeloma Patients.,2022,10.3390/cancers14092228,https://pubmed.ncbi.nlm.nih.gov/35565356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,32493902,"Reverse genetics reveals single gene of every candidate on Hybrid sterility, X Chromosome QTL 2 (Hstx2) are dispensable for spermatogenesis.",2020,10.1038/s41598-020-65986-y,https://pubmed.ncbi.nlm.nih.gov/32493902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,26895102,The cancer-testis antigens SPANX-A/C/D and CTAG2 promote breast cancer invasion.,2016,10.18632/oncotarget.7408,https://pubmed.ncbi.nlm.nih.gov/26895102/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,22596240,"Expression of MAGE-A3, NY-ESO-1, LAGE-1 and PRAME in urothelial carcinoma.",2012,10.1038/bjc.2012.215,https://pubmed.ncbi.nlm.nih.gov/22596240/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,31289029,Long-term safety and activity of NY-ESO-1 SPEAR T cells after autologous stem cell transplant for myeloma.,2019,10.1182/bloodadvances.2019000194,https://pubmed.ncbi.nlm.nih.gov/31289029/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,33237767,Specific Inhibition of Tumor Growth by T Cell Receptor-Drug Conjugates Targeting Intracellular Cancer-Testis Antigen NY-ESO-1/LAGE-1.,2020,10.1021/acs.bioconjchem.0c00548,https://pubmed.ncbi.nlm.nih.gov/33237767/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,33034841,Comprehensive analysis of the immunological landscape of pituitary adenomas: implications of immunotherapy for pituitary adenomas.,2020,10.1007/s11060-020-03636-z,https://pubmed.ncbi.nlm.nih.gov/33034841/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,34283076,Identification of a Novel Tumor Microenvironment Prognostic Signature for Advanced-Stage Serous Ovarian Cancer.,2021,10.3390/cancers13133343,https://pubmed.ncbi.nlm.nih.gov/34283076/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,28183192,A pilot study of peripheral blood BDCA-1 (CD1c) positive dendritic cells pulsed with NY-ESO-1 ISCOMATRIX™ adjuvant.,2017,10.2217/imt-2016-0132,https://pubmed.ncbi.nlm.nih.gov/28183192/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,27294163,"Adjuvant Autologous Melanoma Vaccine for Macroscopic Stage III Disease: Survival, Biomarkers, and Improved Response to CTLA-4 Blockade.",2016,10.1155/2016/8121985,https://pubmed.ncbi.nlm.nih.gov/27294163/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,34356854,Soluble Expression of Fc-Fused T Cell Receptors Allows Yielding Novel Bispecific T Cell Engagers.,2021,10.3390/biomedicines9070790,https://pubmed.ncbi.nlm.nih.gov/34356854/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAG2,ENSG00000126890,Neither,26193344,NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma.,2015,10.1038/nm.3910,https://pubmed.ncbi.nlm.nih.gov/26193344/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAGE1,ENSG00000212710,Neither,42123708,A Post-GWAS Analysis of the Shared Genetic Architecture Between COVID-19 and Coronary Artery Disease.,2026,10.3390/ijms27094132,https://pubmed.ncbi.nlm.nih.gov/42123708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAGE1,ENSG00000212710,Neither,37305699,Proteogenomic landscape of gastric adenocarcinoma peritoneal metastases.,2023,10.1016/j.isci.2023.106913,https://pubmed.ncbi.nlm.nih.gov/37305699/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAGE1,ENSG00000212710,Neither,24850846,Ectopic expression of cancer-testis antigens in cutaneous T-cell lymphoma patients.,2014,10.1158/1078-0432.ccr-14-0307,https://pubmed.ncbi.nlm.nih.gov/24850846/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAGE1,ENSG00000212710,Neither,34958532,Immune and inflammation-related gene polymorphisms and susceptibility to tuberculosis in Southern Xinjiang population: A case-control analysis.,2022,10.1111/iji.12564,https://pubmed.ncbi.nlm.nih.gov/34958532/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAGE1,ENSG00000212710,Neither,20726502,A panel of cancer-testis genes exhibiting broad-spectrum expression in haematological malignancies.,2010,,https://pubmed.ncbi.nlm.nih.gov/20726502/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAGE1,ENSG00000212710,Neither,24573400,Novel cancer-testis antigen expression on glioma cell lines derived from high-grade glioma patients.,2014,10.3892/or.2014.3049,https://pubmed.ncbi.nlm.nih.gov/24573400/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAGE1,ENSG00000212710,Neither,29305299,Identification of OAF and PVRL1 as candidate genes for an ocular anomaly characterized by Peters anomaly type 2 and ectopia lentis.,2018,10.1016/j.exer.2017.12.012,https://pubmed.ncbi.nlm.nih.gov/29305299/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAGE1,ENSG00000212710,Neither,30661054,"Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms.",2019,10.1136/gutjnl-2018-317619,https://pubmed.ncbi.nlm.nih.gov/30661054/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAGE1,ENSG00000212710,Neither,18769116,Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma.,2008,10.4161/cbt.7.10.6565,https://pubmed.ncbi.nlm.nih.gov/18769116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAGE1,ENSG00000212710,Neither,18519675,Genome-wide copy number analysis in esophageal adenocarcinoma using high-density single-nucleotide polymorphism arrays.,2008,10.1158/0008-5472.can-07-6710,https://pubmed.ncbi.nlm.nih.gov/18519675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTAGE1,ENSG00000212710,Neither,11149944,Serological detection of cutaneous T-cell lymphoma-associated antigens.,2001,10.1073/pnas.98.2.629,https://pubmed.ncbi.nlm.nih.gov/11149944/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXorf49,ENSG00000215115,Neither,26078803,Generation of Adducts of 4-Hydroxy-2-nonenal with Heat Shock 60 kDa Protein 1 in Human Promyelocytic HL-60 and Monocytic THP-1 Cell Lines.,2015,10.1155/2015/296146,https://pubmed.ncbi.nlm.nih.gov/26078803/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXorf49B,ENSG00000215113,Neither,32618014,Visual histological assessment of morphological features reflects the underlying molecular profile in invasive breast cancer: a morphomolecular study.,2020,10.1111/his.14199,https://pubmed.ncbi.nlm.nih.gov/32618014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXorf51A,ENSG00000224440,Neither,34415548,Backbone and nearly complete side-chain chemical shift assignments reveal the human uncharacterized protein CXorf51A as intrinsically disordered.,2021,10.1007/s12104-021-10043-6,https://pubmed.ncbi.nlm.nih.gov/34415548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXorf58,ENSG00000165182,Neither,33683453,"Elevated expression of sepiapterin reductase, regulator of G protein signaling 1, hypothetical protein CXorf58 homolog, and zinc finger and BTB domain-containing protein 21 isoform X2 is associated with progression of hepatocellular carcinoma.",2021,10.1007/s00709-021-01632-2,https://pubmed.ncbi.nlm.nih.gov/33683453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXorf58,ENSG00000165182,Neither,34318869,Functionathon: a manual data mining workflow to generate functional hypotheses for uncharacterized human proteins and its application by undergraduate students.,2021,10.1093/database/baab046,https://pubmed.ncbi.nlm.nih.gov/34318869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,39777569,DUO1 Activated Zinc Finger (AtDAZ) protein role in the generative cell body morphogenesis.,2025,10.1007/s11103-024-01542-w,https://pubmed.ncbi.nlm.nih.gov/39777569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,37724144,"Gene Polymorphism, Microdeletion, and Gene Expression of PRM1, PRM2, AZFc in Infertile Males.",2023,10.52547/rbmb.12.1.173,https://pubmed.ncbi.nlm.nih.gov/37724144/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,35358715,Y-chromosome genes associated with sertoli cell-only syndrome identified by array comparative genome hybridization.,2023,10.1016/j.bj.2022.03.009,https://pubmed.ncbi.nlm.nih.gov/35358715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,34721689,Identification and functional annotation of differentially expressed long noncoding RNAs in retinoblastoma.,2021,10.3892/etm.2021.10882,https://pubmed.ncbi.nlm.nih.gov/34721689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,35384611,Comprehensive Transcriptome Analysis of Gonadal and Somatic Tissues for Identification of Sex-Related Genes in the Largemouth Bass Micropterus salmoides.,2022,10.1007/s10126-022-10127-x,https://pubmed.ncbi.nlm.nih.gov/35384611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,39076347,The male germ unit association is independently regulated of GUM in Arabidopsis thaliana.,2024,10.1002/pld3.624,https://pubmed.ncbi.nlm.nih.gov/39076347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,34274474,Identification of genomic imbalances (CNVs as well as LOH) in sertoli cell only syndrome cases through cytoscan microarray.,2021,10.1016/j.gene.2021.145851,https://pubmed.ncbi.nlm.nih.gov/34274474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,25994570,"Transcriptome analysis of the cancer/testis genes, DAZ1, AURKC, and TEX101, in breast tumors and six breast cancer cell lines.",2015,10.1007/s13277-015-3546-4,https://pubmed.ncbi.nlm.nih.gov/25994570/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,26162009,Isoform-Level Gene Expression Profiles of Human Y Chromosome Azoospermia Factor Genes and Their X Chromosome Paralogs in the Testicular Tissue of Non-Obstructive Azoospermia Patients.,2015,10.1021/acs.jproteome.5b00520,https://pubmed.ncbi.nlm.nih.gov/26162009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,24341089,[Detecting testis- and epididymis-specific methylated promoters in human cell-free seminal DNA by MeDIP-qPCR].,2013,,https://pubmed.ncbi.nlm.nih.gov/24341089/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,25973848,Differential Genes Expression between Fertile and Infertile Spermatozoa Revealed by Transcriptome Analysis.,2015,10.1371/journal.pone.0127007,https://pubmed.ncbi.nlm.nih.gov/25973848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,26931020,[Association of the deleted DAZ gene copy related to gr/gr and b2/b3 deletions with spermatogenic impairment].,2016,,https://pubmed.ncbi.nlm.nih.gov/26931020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,30050315,Independent of DAZL-T54A variant and AZF microdeletion in a sample of Egyptian patients with idiopathic non-obstructed azoospermia.,2018,10.2147/tacg.s158297,https://pubmed.ncbi.nlm.nih.gov/30050315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,24878370,Combined deletion of DAZ2 and DAZ4 copies of Y chromosome DAZ gene is associated with male infertility in Tunisian men.,2014,10.1016/j.gene.2014.05.061,https://pubmed.ncbi.nlm.nih.gov/24878370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,20823911,Associations of Y-chromosome subdeletion gr/gr with the prevalence of Y-chromosome haplogroups in infertile patients.,2011,10.1038/ejhg.2010.151,https://pubmed.ncbi.nlm.nih.gov/20823911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,23388839,Greater prevalence of Y chromosome Q1a3a haplogroup in Y-microdeleted Chilean men: a case-control study.,2013,10.1007/s10815-013-9950-z,https://pubmed.ncbi.nlm.nih.gov/23388839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,16372120,A differentially methylated region of the DAZ1 gene in spermatic and somatic cells.,2006,10.1111/j.1745-7262.2006.00069.x,https://pubmed.ncbi.nlm.nih.gov/16372120/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,17268180,Genomic structure and transcript variants of the bovine DAZL gene.,2007,10.1159/000097419,https://pubmed.ncbi.nlm.nih.gov/17268180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,27723784,Discrimination of Deletion and Duplication Subtypes of the Deleted in Azoospermia Gene Family in the Context of Frequent Interloci Gene Conversion.,2016,10.1371/journal.pone.0163936,https://pubmed.ncbi.nlm.nih.gov/27723784/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,21852246,Additional genomic duplications in AZFc underlie the b2/b3 deletion-associated risk of spermatogenic impairment in Han Chinese population.,2011,10.1093/hmg/ddr369,https://pubmed.ncbi.nlm.nih.gov/21852246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,33536392,Development of a new in vitro assay system for evaluating the effects of chemicals on DNA methylation.,2021,10.2131/jts.46.83,https://pubmed.ncbi.nlm.nih.gov/33536392/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,19223287,Polymorphic expression of DAZ proteins in the human testis.,2009,10.1093/humrep/dep032,https://pubmed.ncbi.nlm.nih.gov/19223287/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,18385127,Restricted expression of the human DAZ protein in premeiotic germ cells.,2008,10.1093/humrep/den099,https://pubmed.ncbi.nlm.nih.gov/18385127/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ1,ENSG00000188120,Neither,10936047,Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome.,2000,10.1006/geno.2000.6260,https://pubmed.ncbi.nlm.nih.gov/10936047/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,42286492,Diversity of molecular karyotypes of 234 pediatric patients with autism spectrum disorder in chromosomal microarray analysis.,2026,10.1186/s12888-026-08263-y,https://pubmed.ncbi.nlm.nih.gov/42286492/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,39777569,DUO1 Activated Zinc Finger (AtDAZ) protein role in the generative cell body morphogenesis.,2025,10.1007/s11103-024-01542-w,https://pubmed.ncbi.nlm.nih.gov/39777569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,34653405,Direct reprogramming of human Sertoli cells into male germline stem cells with the self-renewal and differentiation potentials via overexpressing DAZL/DAZ2/BOULE genes.,2021,10.1016/j.stemcr.2021.09.011,https://pubmed.ncbi.nlm.nih.gov/34653405/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,35358715,Y-chromosome genes associated with sertoli cell-only syndrome identified by array comparative genome hybridization.,2023,10.1016/j.bj.2022.03.009,https://pubmed.ncbi.nlm.nih.gov/35358715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,27457284,gr/gr-DAZ2-DAZ4-CDY1b deletion is a high-risk factor for male infertility in Tunisian population.,2016,10.1016/j.gene.2016.07.050,https://pubmed.ncbi.nlm.nih.gov/27457284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,34938099,Fetal Nucleated Red Blood Cells Preferable Than Cell-Free Fetal DNA for Early Determination of Gender Among Invasive and Non-Invasive Source Using Novel Four Genes Multiplex PCR.,2021,10.2147/ijgm.s345345,https://pubmed.ncbi.nlm.nih.gov/34938099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,26931020,[Association of the deleted DAZ gene copy related to gr/gr and b2/b3 deletions with spermatogenic impairment].,2016,,https://pubmed.ncbi.nlm.nih.gov/26931020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,24878370,Combined deletion of DAZ2 and DAZ4 copies of Y chromosome DAZ gene is associated with male infertility in Tunisian men.,2014,10.1016/j.gene.2014.05.061,https://pubmed.ncbi.nlm.nih.gov/24878370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,27723784,Discrimination of Deletion and Duplication Subtypes of the Deleted in Azoospermia Gene Family in the Context of Frequent Interloci Gene Conversion.,2016,10.1371/journal.pone.0163936,https://pubmed.ncbi.nlm.nih.gov/27723784/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,20823911,Associations of Y-chromosome subdeletion gr/gr with the prevalence of Y-chromosome haplogroups in infertile patients.,2011,10.1038/ejhg.2010.151,https://pubmed.ncbi.nlm.nih.gov/20823911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,23388839,Greater prevalence of Y chromosome Q1a3a haplogroup in Y-microdeleted Chilean men: a case-control study.,2013,10.1007/s10815-013-9950-z,https://pubmed.ncbi.nlm.nih.gov/23388839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,16963411,[Study on DAZ gene copy deletion in severe oligozoospermia sperm donor for ICSI].,2006,10.1360/yc-006-1057,https://pubmed.ncbi.nlm.nih.gov/16963411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,17416365,AZFc partial deletions in Chilean men with severe spermatogenic failure.,2007,10.1016/j.fertnstert.2007.01.038,https://pubmed.ncbi.nlm.nih.gov/17416365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,16596261,Quantitative evaluation of partial deletions of the DAZ gene cluster.,2006,10.3892/ijmm.17.5.785,https://pubmed.ncbi.nlm.nih.gov/16596261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,9557839,DAZ (Deleted in AZoospermia) genes encode proteins located in human late spermatids and in sperm tails.,1998,10.1093/humrep/13.2.363,https://pubmed.ncbi.nlm.nih.gov/9557839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,20039973,Differential effect of specific gr/gr deletion subtypes on spermatogenesis in the Chinese Han population.,2010,10.1111/j.1365-2605.2009.01015.x,https://pubmed.ncbi.nlm.nih.gov/20039973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,16674553,A frequent partial AZFc deletion does not render an increased risk of spermatogenic impairment in East Asians.,2006,10.1111/j.1529-8817.2005.00231.x,https://pubmed.ncbi.nlm.nih.gov/16674553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,19953495,[Breakpoint localization of Y-chromosome massive deletions in 49 spermatogenesis dysfunction patients].,2009,10.3760/cma.j.issn.1003-9406.2009.06.017,https://pubmed.ncbi.nlm.nih.gov/19953495/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,20873591,[Partial AZfc region deletions of the Y chromosome in spermatogenic dysfunction patients].,2010,,https://pubmed.ncbi.nlm.nih.gov/20873591/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,15744033,Association of partial AZFc region deletions with spermatogenic impairment and male infertility.,2005,10.1136/jmg.2004.025833,https://pubmed.ncbi.nlm.nih.gov/15744033/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ2,ENSG00000205944,Neither,10936047,Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome.,2000,10.1006/geno.2000.6260,https://pubmed.ncbi.nlm.nih.gov/10936047/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,42801374,Comparative evaluation of germ cell-specific promoters identifies robust drivers of transgene expression during mouse spermatogenesis.,2026,10.1007/s11033-026-12822-7,https://pubmed.ncbi.nlm.nih.gov/42801374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,42791791,Associations of Bovine Fetal Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells and Germ Cell Marker Expression in Testicular Organoids.,2026,10.3390/ani16182933,https://pubmed.ncbi.nlm.nih.gov/42791791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,41249172,Loss of full-length DAZL isoform disrupts PABPC1-dependent translational regulation and meiosis.,2025,10.1038/s41419-025-08179-7,https://pubmed.ncbi.nlm.nih.gov/41249172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,42793110,Isolation and Characterization of Rabbit Spermatogonial Stem Cells as a Promising Animal Genetic Resource for Biodiversity Protection.,2026,10.3390/biom16091278,https://pubmed.ncbi.nlm.nih.gov/42793110/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,42074256,Intermittent Fasting Ameliorates Testicular Damage via Oxidative Stress Modulation in a Genetic Absence Epilepsy Rat Model.,2026,10.3390/ijms27083619,https://pubmed.ncbi.nlm.nih.gov/42074256/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,42467772,PUM1 and PUM2 promote translation of chromatin regulators to ensure mammalian spermatogenesis.,2026,10.1126/sciadv.aed5708,https://pubmed.ncbi.nlm.nih.gov/42467772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,42703821,Gene Expression Dynamics and Network Analysis Reveal Key Molecular Pathways in Spermatogenic Progression from Spermatogonial Stem Cells to Round Spermatids.,2026,10.22074/ijfs.2025.2064261.1893,https://pubmed.ncbi.nlm.nih.gov/42703821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,41708791,Targeted activation of Nrf2 via sulforaphane-loaded exosomes attenuated azoospermic condition in the rat model.,2026,10.1038/s41598-026-40709-x,https://pubmed.ncbi.nlm.nih.gov/41708791/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,41960164,Low-level lasers can improve spermatogenesis in infertile mice by targeting molecular pathways.,2026,10.34172/bi.31018,https://pubmed.ncbi.nlm.nih.gov/41960164/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,42501539,DAZL-targeted inducible kill switches enable efficient ablation of chicken primordial germ cells.,2026,10.1016/j.psj.2026.107459,https://pubmed.ncbi.nlm.nih.gov/42501539/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,41665013,Azoospermia phenotype and scRNA-seq reveal hnRNPK as a factor essential for male germ cell development in mice.,2026,10.1093/nar/gkag108,https://pubmed.ncbi.nlm.nih.gov/41665013/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,42009850,Germline organoids develop in vitro from embryonic Taeniopygia guttata (zebra finch) cultures.,2026,10.1038/s41598-026-46600-z,https://pubmed.ncbi.nlm.nih.gov/42009850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,42665132,Endocrine disrupting effects of estrone on male Siniperca chuatsi: From gonadal remodeling to gene regulation.,2027,10.1016/j.jsbmb.2026.107107,https://pubmed.ncbi.nlm.nih.gov/42665132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,40567906,"Chrysin's protective effect on the expression of &lt;i&gt;protamine&lt;/i&gt;, &lt;i&gt;Tsga10&lt;/i&gt;, &lt;i&gt;Dazl&lt;/i&gt;, and &lt;i&gt;Akap4&lt;/i&gt; genes against diazinon toxin in male rats: An experimental study.",2025,10.18502/ijrm.v23i3.18778,https://pubmed.ncbi.nlm.nih.gov/40567906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,41148839,Propiconazole-Induced Testis Damage and MAPK-Mediated Apoptosis and Autophagy in Germ Cells.,2025,10.3390/cells14201624,https://pubmed.ncbi.nlm.nih.gov/41148839/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,40011410,Investigating the Impact of Bismuth Oxide Nanoparticles on Dazl Gene Expression and Spermatogenesis Indices in Male Mice.,2025,10.1007/s12011-025-04554-9,https://pubmed.ncbi.nlm.nih.gov/40011410/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,41112081,Evaluation of conditioned medium from Sertoli cells as a potential inducer of &lt;i&gt;in vitro&lt;/i&gt; germ cell differentiation of bovine fetal mesenchymal stem cells (MSCs).,2025,10.1590/1984-3143-ar2024-0094,https://pubmed.ncbi.nlm.nih.gov/41112081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,40713602,The synergic impact of decellularized testis scaffold and extracellular vesicles derived from human semen on spermatogonial stem cell survival and differentiation.,2025,10.1186/s12938-025-01424-2,https://pubmed.ncbi.nlm.nih.gov/40713602/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,38588931,A novel cancer-germline gene DAZL promotes progression and cisplatin resistance of non-small cell lung cancer by upregulating JAK2 and MCM8.,2024,10.1016/j.gene.2024.148449,https://pubmed.ncbi.nlm.nih.gov/38588931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,40263616,The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity.,2025,10.1038/s43587-025-00852-y,https://pubmed.ncbi.nlm.nih.gov/40263616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,42721757,"Chronic labetalol exposure induced dose-dependent testicular toxicity via disruptingt HPG-axis, spermatogenesis and steroidogenic pathways: A biochemical, molecular and histopathological evidence.",2026,10.1016/j.tice.2026.103924,https://pubmed.ncbi.nlm.nih.gov/42721757/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,41441253,Di(2-ethylhexyl) Phthalate Alters Primordial Germ Cell Distribution and the Reproductive Neuroendocrine Regulatory Axis in Zebrafish Embryos.,2025,10.3390/toxics13121032,https://pubmed.ncbi.nlm.nih.gov/41441253/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,41874152,Generation of Primordial Germ Cell-like Cells from hESCs Using BMP4 and hAFSC-Conditioned Medium.,2026,10.3390/mps9020035,https://pubmed.ncbi.nlm.nih.gov/41874152/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,42069234,Impact of 5-alpha reductase inhibitors on male reproductive health: A review of finasteride and dutasteride.,2026,10.1016/j.reprotox.2026.109257,https://pubmed.ncbi.nlm.nih.gov/42069234/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,40926636,Establishment and optimization of the two-step induction system for generating primordial germ cell-like cells from chicken embryonic stem cells.,2026,10.1002/2211-5463.70116,https://pubmed.ncbi.nlm.nih.gov/40926636/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,39920257,Comparison of saliva and blood derived cell free RNAs for detecting oral squamous cell carcinoma.,2025,10.1038/s41598-025-88472-9,https://pubmed.ncbi.nlm.nih.gov/39920257/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,40349219,Evolving Lessons on Metazoan Primordial Germ Cells in Diversity and Development.,2025,10.1002/mrd.70027,https://pubmed.ncbi.nlm.nih.gov/40349219/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,41016373,Tannic acid protection against oxidative and inflammatory effects of monosodium glutamate on testis: Molecular and biochemical approach.,2025,10.1016/j.repbio.2025.101077,https://pubmed.ncbi.nlm.nih.gov/41016373/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,41072890,"Linking GLP-1 activation with steroidogenesis, redox, endoplasmic reticulum stress, mitophagy, and the apoptotic regulatory network unlocks the emerging impacts of semaglutide on 5-fluorouracil-induced testicular toxicity.",2025,10.1016/j.lfs.2025.124014,https://pubmed.ncbi.nlm.nih.gov/41072890/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,40186081,Molecular Changes Associated with Inflammation and Reproduction in Cadmium-Induced Testicular Toxicity: Mitigating Effect of Lactobacillus plantarum.,2025,10.1007/s12011-025-04601-5,https://pubmed.ncbi.nlm.nih.gov/40186081/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,40347279,Investigation of the effect of tannic acid on doxorubicin-ınduced testicular damage and functions in a rat model.,2025,10.1007/s00210-025-04238-0,https://pubmed.ncbi.nlm.nih.gov/40347279/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,41876515,Machine learning-based predictive models and subtypes patterns in peripheral blood of schizophrenia based on a machine learning computational framework.,2026,10.1038/s41537-026-00744-z,https://pubmed.ncbi.nlm.nih.gov/41876515/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,37947660,&lt;i&gt;DAZL&lt;/i&gt; Knockout Pigs as Recipients for Spermatogonial Stem Cell Transplantation.,2023,10.3390/cells12212582,https://pubmed.ncbi.nlm.nih.gov/37947660/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,8968756,The human autosomal gene DAZLA: testis specificity and a candidate for male infertility.,1996,10.1093/hmg/5.12.2013,https://pubmed.ncbi.nlm.nih.gov/8968756/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,8968755,A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad.,1996,10.1093/hmg/5.12.2005,https://pubmed.ncbi.nlm.nih.gov/8968755/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZL,ENSG00000092345,Neither,8896558,"The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.",1996,10.1038/ng1196-292,https://pubmed.ncbi.nlm.nih.gov/8896558/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,41493231,Bidirectional interaction between protocadherin 8 and the transcription factor Dbx1 regulates cerebral cortex development.,2026,10.1242/dev.205011,https://pubmed.ncbi.nlm.nih.gov/41493231/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,40995053,Homozygous &lt;i&gt;DBX1&lt;/i&gt; Nonsense Variant in a Case of Atypical Congenital Central Hypoventilation.,2025,10.1212/nxg.0000000000200302,https://pubmed.ncbi.nlm.nih.gov/40995053/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,42543528,Encapsulation and Controlled Release of Human Spinal Cord Organoid-Derived Extracellular Vesicles for Tissue Patterning in Viscoelastic Hyaluronic Acid Hydrogels.,2026,10.1002/adhm.71472,https://pubmed.ncbi.nlm.nih.gov/42543528/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,40623315,Astrocyte regeneration via FGF8-DBX1 signalling facilitates recovery in neuromyelitis optica rats.,2025,10.1093/brain/awaf148,https://pubmed.ncbi.nlm.nih.gov/40623315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,39612187,Potassium Release From the Habenular Astrocytes Induces Depressive-Like Behaviors in Mice.,2025,10.1002/glia.24647,https://pubmed.ncbi.nlm.nih.gov/39612187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,38344749,Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron fate and regulates differentiation of the dorsal midbrain into the inferior and superior colliculi.,2024,10.3389/fcell.2024.1336308,https://pubmed.ncbi.nlm.nih.gov/38344749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,37081114,The embryonic patterning gene Dbx1 governs the survival of the auditory midbrain via Tcf7l2-Ap2δ transcriptional cascade.,2023,10.1038/s41418-023-01165-6,https://pubmed.ncbi.nlm.nih.gov/37081114/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,37849047,Connectivity and molecular profiles of Foxp2- and Dbx1-lineage neurons in the accessory olfactory bulb and medial amygdala.,2024,10.1002/cne.25545,https://pubmed.ncbi.nlm.nih.gov/37849047/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,38729762,Inhibitory Subpopulations in preBötzinger Complex Play Distinct Roles in Modulating Inspiratory Rhythm and Pattern.,2024,10.1523/jneurosci.1928-23.2024,https://pubmed.ncbi.nlm.nih.gov/38729762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,38862622,Fine mapping and candidate gene analysis of Dravet syndrome modifier loci on mouse chromosomes 7 and 8.,2024,10.1007/s00335-024-10046-3,https://pubmed.ncbi.nlm.nih.gov/38862622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,37946049,Transcriptionally defined amygdala subpopulations play distinct roles in innate social behaviors.,2023,10.1038/s41593-023-01475-5,https://pubmed.ncbi.nlm.nih.gov/37946049/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,38774786,Postinspiratory and preBötzinger complexes contribute to respiratory-sympathetic coupling in mice before and after chronic intermittent hypoxia.,2024,10.3389/fnins.2024.1386737,https://pubmed.ncbi.nlm.nih.gov/38774786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,37125418,Diversity within olfactory sensory derivatives revealed by the contribution of Dbx1 lineages.,2023,10.1002/cne.25492,https://pubmed.ncbi.nlm.nih.gov/37125418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,36583530,Coordinated cadherin functions sculpt respiratory motor circuit connectivity.,2022,10.7554/elife.82116,https://pubmed.ncbi.nlm.nih.gov/36583530/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,35190626,Transcriptomes of electrophysiologically recorded Dbx1-derived respiratory neurons of the preBötzinger complex in neonatal mice.,2022,10.1038/s41598-022-06834-z,https://pubmed.ncbi.nlm.nih.gov/35190626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,35858334,Optogenetic stimulation of pre-Bötzinger complex reveals novel circuit interactions in swallowing-breathing coordination.,2022,10.1073/pnas.2121095119,https://pubmed.ncbi.nlm.nih.gov/35858334/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,35815610,Dbx1 controls the development of astrocytes of the intermediate spinal cord by modulating Notch signaling.,2022,10.1242/dev.200750,https://pubmed.ncbi.nlm.nih.gov/35815610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,33863910,Specific contribution of neurons from the Dbx1 lineage to the piriform cortex.,2021,10.1038/s41598-021-86512-8,https://pubmed.ncbi.nlm.nih.gov/33863910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,34614492,Analysis of the Expression Pattern of Cajal-Retzius Cell Markers in the Xenopus laevis Forebrain.,2022,10.1159/000519025,https://pubmed.ncbi.nlm.nih.gov/34614492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,35399523,Rnf220 is Implicated in the Dorsoventral Patterning of the Hindbrain Neural Tube in Mice.,2022,10.3389/fcell.2022.831365,https://pubmed.ncbi.nlm.nih.gov/35399523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,34535684,Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity.,2021,10.1038/s41467-021-25829-4,https://pubmed.ncbi.nlm.nih.gov/34535684/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,26290237,Synaptic Depression Influences Inspiratory-Expiratory Phase Transition in Dbx1 Interneurons of the preBötzinger Complex in Neonatal Mice.,2015,10.1523/jneurosci.0351-15.2015,https://pubmed.ncbi.nlm.nih.gov/26290237/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,34380764,C-Boutons and Their Influence on Amyotrophic Lateral Sclerosis Disease Progression.,2021,10.1523/jneurosci.0660-21.2021,https://pubmed.ncbi.nlm.nih.gov/34380764/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,28360327,Breathing control center neurons that promote arousal in mice.,2017,10.1126/science.aai7984,https://pubmed.ncbi.nlm.nih.gov/28360327/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBX1,ENSG00000109851,Neither,25089541,Whole genome DNA methylation signature of HER2-positive breast cancer.,2014,10.4161/epi.29632,https://pubmed.ncbi.nlm.nih.gov/25089541/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF4L2,ENSG00000176566,Neither,39830022,Circulating tumor DNA analysis for prediction of prognosis and molecular insights in patients with resectable gastric cancer: results from a prospective study.,2025,10.1002/mco2.70065,https://pubmed.ncbi.nlm.nih.gov/39830022/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF4L2,ENSG00000176566,Neither,33012505,LncRNA ST8SIA6-AS1 promotes hepatocellular carcinoma progression by regulating MAGEA3 and DCAF4L2 expression.,2020,10.1016/j.bbrc.2020.09.115,https://pubmed.ncbi.nlm.nih.gov/33012505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF4L2,ENSG00000176566,Neither,32685988,Aberrant DNA methylation results in altered gene expression in non-alcoholic steatohepatitis-related hepatocellular carcinomas.,2020,10.1007/s00432-020-03298-4,https://pubmed.ncbi.nlm.nih.gov/32685988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF4L2,ENSG00000176566,Neither,27158335,DCAF4L2 promotes colorectal cancer invasion and metastasis via mediating degradation of NFκb negative regulator PPM1B.,2016,,https://pubmed.ncbi.nlm.nih.gov/27158335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF4L2,ENSG00000176566,Neither,32452127,An approach using Caenorhabditis elegans screening novel targets to suppress tumour cell proliferation.,2020,10.1111/cpr.12832,https://pubmed.ncbi.nlm.nih.gov/32452127/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF4L2,ENSG00000176566,Neither,31897186,Monitoring methylation-driven genes as prognostic biomarkers in patients with lung squamous cell cancer.,2020,10.3892/ol.2019.11163,https://pubmed.ncbi.nlm.nih.gov/31897186/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF4L2,ENSG00000176566,Neither,35191549,Genome-wide association study of multiethnic nonsyndromic orofacial cleft families identifies novel loci specific to family and phenotypic subtypes.,2022,10.1002/gepi.22447,https://pubmed.ncbi.nlm.nih.gov/35191549/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF4L2,ENSG00000176566,Neither,33898419,Genome-Wide Association Study of Non-syndromic Orofacial Clefts in a Multiethnic Sample of Families and Controls Identifies Novel Regions.,2021,10.3389/fcell.2021.621482,https://pubmed.ncbi.nlm.nih.gov/33898419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF4L2,ENSG00000176566,Neither,25631615,Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology.,2015,10.1002/gepi.21886,https://pubmed.ncbi.nlm.nih.gov/25631615/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF4L2,ENSG00000176566,Neither,23512105,Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study.,2013,10.1007/s00439-013-1283-6,https://pubmed.ncbi.nlm.nih.gov/23512105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCDC2C,ENSG00000214866,Neither,42646583,DCDC2C Protein Expression in Human Spermatozoa: A Potential Molecular Marker for Asthenozoospermia.,2026,10.3390/medsci14040449,https://pubmed.ncbi.nlm.nih.gov/42646583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCDC2C,ENSG00000214866,Neither,35405299,Stress and the brain transcriptome: Identifying commonalities and clusters in standardized data from published experiments.,2022,10.1016/j.pnpbp.2022.110558,https://pubmed.ncbi.nlm.nih.gov/35405299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCDC2C,ENSG00000214866,Neither,32414370,Identification of single-nucleotide variants associated with susceptibility to Salmonella in pigs using a genome-wide association approach.,2020,10.1186/s12917-020-02344-0,https://pubmed.ncbi.nlm.nih.gov/32414370/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCDC2C,ENSG00000214866,Neither,29313708,Human Lung DNA Methylation Quantitative Trait Loci Colocalize with Chronic Obstructive Pulmonary Disease Genome-Wide Association Loci.,2018,10.1164/rccm.201707-1434oc,https://pubmed.ncbi.nlm.nih.gov/29313708/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCDC2C,ENSG00000214866,Neither,28395323,Defining the human sperm microtubulome: an integrated genomics approach.,2017,10.1095/biolreprod.116.143479,https://pubmed.ncbi.nlm.nih.gov/28395323/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,41146334,Influence of DEFB4 copy number variants on gene expression in monocytes.,2025,10.1186/s13104-025-07529-0,https://pubmed.ncbi.nlm.nih.gov/41146334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,42737534,Temporal Transcriptomic Profiling of NMBA-Induced Rat Esophageal Squamous Carcinogenesis Identifies Early Inflammatory Activation and Late NRF2-Associated Oxidative-Stress Remodeling.,2026,10.3390/ijms27177632,https://pubmed.ncbi.nlm.nih.gov/42737534/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,41594349,Functional Role and Diagnostic Potential of Biomarkers in the Early Detection of Mastitis in Dairy Cows.,2026,10.3390/ani16020159,https://pubmed.ncbi.nlm.nih.gov/41594349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,41737462,3D-printed PRP-infused double-network hydrogels orchestrate inflammation resolution and vascular regeneration in infected wounds.,2026,10.1016/j.mtbio.2026.102841,https://pubmed.ncbi.nlm.nih.gov/41737462/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,40243580,IL-17 Ligand and Receptor Family Members Are Differentially Expressed by Keratinocyte Subpopulations and Modulate Their Differentiation and Inflammatory Phenotype.,2025,10.3390/ijms26072989,https://pubmed.ncbi.nlm.nih.gov/40243580/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,41218476,Therapeutic potential of AAV8-mediated IL-17RA extracellular domain gene delivery in an imiquimod-induced mouse model of psoriasis.,2025,10.1016/j.molimm.2025.11.001,https://pubmed.ncbi.nlm.nih.gov/41218476/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,38855942,Drug repositioning identifies histone deacetylase inhibitors that promote innate immunity in non-tuberculous mycobacterial infection.,2024,10.1139/cjm-2023-0127,https://pubmed.ncbi.nlm.nih.gov/38855942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,38760394,Mycobacterium tuberculosis suppresses host antimicrobial peptides by dehydrogenating L-alanine.,2024,10.1038/s41467-024-48588-4,https://pubmed.ncbi.nlm.nih.gov/38760394/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,39018106,Postbiotic lactobacilli induce cutaneous antimicrobial response and restore the barrier to inhibit the intracellular invasion of Staphylococcus aureus in vitro and ex vivo.,2024,10.1096/fj.202400054rr,https://pubmed.ncbi.nlm.nih.gov/39018106/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,37822359,Airway epithelial cells mount an early response to mycobacterial infection.,2023,10.3389/fcimb.2023.1253037,https://pubmed.ncbi.nlm.nih.gov/37822359/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,39781190,Aged garlic extract enhances the production of β‑defensin 4 via activation of the Wnt/β‑catenin pathway in mouse gingiva.,2025,10.3892/etm.2024.12791,https://pubmed.ncbi.nlm.nih.gov/39781190/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,35057465,Emerging Roles of Vitamin D-Induced Antimicrobial Peptides in Antiviral Innate Immunity.,2022,10.3390/nu14020284,https://pubmed.ncbi.nlm.nih.gov/35057465/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,37032461,Age of onset defines two distinct profiles of atopic dermatitis in adults.,2023,10.1111/all.15741,https://pubmed.ncbi.nlm.nih.gov/37032461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,36825010,Heat shock protein 90 inhibitor RGRN-305 potently attenuates skin inflammation.,2023,10.3389/fimmu.2023.1128897,https://pubmed.ncbi.nlm.nih.gov/36825010/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,35213752,Cytokine induced 3-D organotypic psoriasis skin model demonstrates distinct roles for NF-κB and JAK pathways in disease pathophysiology.,2022,10.1111/exd.14551,https://pubmed.ncbi.nlm.nih.gov/35213752/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,32551953,"Copy number variation, gene expression and histological localization of human beta-defensin 2 in patients with adeno-tonsillar hypertrophy.",2020,10.1080/10520295.2020.1752936,https://pubmed.ncbi.nlm.nih.gov/32551953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,31537016,"Beta-defensins and analogs in Helicobacter pylori infections: mRNA expression levels, DNA methylation, and antibacterial activity.",2019,10.1371/journal.pone.0222295,https://pubmed.ncbi.nlm.nih.gov/31537016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,33301461,Interleukin-17A pathway target genes are upregulated in Equus caballus supporting limb laminitis.,2020,10.1371/journal.pone.0232920,https://pubmed.ncbi.nlm.nih.gov/33301461/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,31421125,Targeting the IL-17 Receptor Using Liposomal Spherical Nucleic Acids as Topical Therapy for Psoriasis.,2020,10.1016/j.jid.2019.06.146,https://pubmed.ncbi.nlm.nih.gov/31421125/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,31548051,Neutrophil β-defensin gene expression of postpartum dairy cows is altered by prepartum dietary cation-anion difference.,2019,10.3168/jds.2019-17216,https://pubmed.ncbi.nlm.nih.gov/31548051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,34575956,Immunomodulatory Properties of Umbilical Cord Blood-Derived Small Extracellular Vesicles and Their Therapeutic Potential for Inflammatory Skin Disorders.,2021,10.3390/ijms22189797,https://pubmed.ncbi.nlm.nih.gov/34575956/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,31948839,Ex vivo culture of lesional psoriasis skin for pharmacological testing.,2020,10.1016/j.jdermsci.2019.12.010,https://pubmed.ncbi.nlm.nih.gov/31948839/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,23543857,Copy Number Variation within Human β-Defensin Gene Cluster Influences Progression to AIDS in the Multicenter AIDS Cohort Study.,2012,10.4172/2155-6113.1000184,https://pubmed.ncbi.nlm.nih.gov/23543857/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,27056267,Streptococcus pyogenes-induced cutaneous lymphocyte antigen-positive T cell-dependent epidermal cell activation triggers TH17 responses in patients with guttate psoriasis.,2016,10.1016/j.jaci.2016.02.008,https://pubmed.ncbi.nlm.nih.gov/27056267/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,27727278,Associations of Toll-Like Receptor and β-Defensin Polymorphisms with Measures of Periodontal Disease (PD) in HIV+ North American Adults: An Exploratory Study.,2016,10.1371/journal.pone.0164075,https://pubmed.ncbi.nlm.nih.gov/27727278/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,25143364,IL-32 is a molecular marker of a host defense network in human tuberculosis.,2014,10.1126/scitranslmed.3009546,https://pubmed.ncbi.nlm.nih.gov/25143364/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,24714768,Interleukin-19 as a translational indicator of renal injury.,2015,10.1007/s00204-014-1237-3,https://pubmed.ncbi.nlm.nih.gov/24714768/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104A,ENSG00000176782,Neither,11481241,Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity.,2001,10.1096/fj.00-0865fje,https://pubmed.ncbi.nlm.nih.gov/11481241/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,41146334,Influence of DEFB4 copy number variants on gene expression in monocytes.,2025,10.1186/s13104-025-07529-0,https://pubmed.ncbi.nlm.nih.gov/41146334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,42737534,Temporal Transcriptomic Profiling of NMBA-Induced Rat Esophageal Squamous Carcinogenesis Identifies Early Inflammatory Activation and Late NRF2-Associated Oxidative-Stress Remodeling.,2026,10.3390/ijms27177632,https://pubmed.ncbi.nlm.nih.gov/42737534/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,41594349,Functional Role and Diagnostic Potential of Biomarkers in the Early Detection of Mastitis in Dairy Cows.,2026,10.3390/ani16020159,https://pubmed.ncbi.nlm.nih.gov/41594349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,41737462,3D-printed PRP-infused double-network hydrogels orchestrate inflammation resolution and vascular regeneration in infected wounds.,2026,10.1016/j.mtbio.2026.102841,https://pubmed.ncbi.nlm.nih.gov/41737462/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,40243580,IL-17 Ligand and Receptor Family Members Are Differentially Expressed by Keratinocyte Subpopulations and Modulate Their Differentiation and Inflammatory Phenotype.,2025,10.3390/ijms26072989,https://pubmed.ncbi.nlm.nih.gov/40243580/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,39696495,Epigenetic regulation on left atrial function and disease recurrence after catheter ablation in atrial fibrillation.,2024,10.1186/s13148-024-01794-9,https://pubmed.ncbi.nlm.nih.gov/39696495/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,41218476,Therapeutic potential of AAV8-mediated IL-17RA extracellular domain gene delivery in an imiquimod-induced mouse model of psoriasis.,2025,10.1016/j.molimm.2025.11.001,https://pubmed.ncbi.nlm.nih.gov/41218476/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,39967509,A Genome-Wide Survey of DNA Methylation Status in Whole Blood of Patients With Hidradenitis Suppurativa Suggests Systemic Immune Dysregulation and Systemic Disease Burden.,2025,10.1111/exd.70065,https://pubmed.ncbi.nlm.nih.gov/39967509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,38855942,Drug repositioning identifies histone deacetylase inhibitors that promote innate immunity in non-tuberculous mycobacterial infection.,2024,10.1139/cjm-2023-0127,https://pubmed.ncbi.nlm.nih.gov/38855942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,38760394,Mycobacterium tuberculosis suppresses host antimicrobial peptides by dehydrogenating L-alanine.,2024,10.1038/s41467-024-48588-4,https://pubmed.ncbi.nlm.nih.gov/38760394/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,39018106,Postbiotic lactobacilli induce cutaneous antimicrobial response and restore the barrier to inhibit the intracellular invasion of Staphylococcus aureus in vitro and ex vivo.,2024,10.1096/fj.202400054rr,https://pubmed.ncbi.nlm.nih.gov/39018106/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,37822359,Airway epithelial cells mount an early response to mycobacterial infection.,2023,10.3389/fcimb.2023.1253037,https://pubmed.ncbi.nlm.nih.gov/37822359/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,39781190,Aged garlic extract enhances the production of β‑defensin 4 via activation of the Wnt/β‑catenin pathway in mouse gingiva.,2025,10.3892/etm.2024.12791,https://pubmed.ncbi.nlm.nih.gov/39781190/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,35057465,Emerging Roles of Vitamin D-Induced Antimicrobial Peptides in Antiviral Innate Immunity.,2022,10.3390/nu14020284,https://pubmed.ncbi.nlm.nih.gov/35057465/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,37032461,Age of onset defines two distinct profiles of atopic dermatitis in adults.,2023,10.1111/all.15741,https://pubmed.ncbi.nlm.nih.gov/37032461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,36825010,Heat shock protein 90 inhibitor RGRN-305 potently attenuates skin inflammation.,2023,10.3389/fimmu.2023.1128897,https://pubmed.ncbi.nlm.nih.gov/36825010/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,35213752,Cytokine induced 3-D organotypic psoriasis skin model demonstrates distinct roles for NF-κB and JAK pathways in disease pathophysiology.,2022,10.1111/exd.14551,https://pubmed.ncbi.nlm.nih.gov/35213752/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,32551953,"Copy number variation, gene expression and histological localization of human beta-defensin 2 in patients with adeno-tonsillar hypertrophy.",2020,10.1080/10520295.2020.1752936,https://pubmed.ncbi.nlm.nih.gov/32551953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,31537016,"Beta-defensins and analogs in Helicobacter pylori infections: mRNA expression levels, DNA methylation, and antibacterial activity.",2019,10.1371/journal.pone.0222295,https://pubmed.ncbi.nlm.nih.gov/31537016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,33301461,Interleukin-17A pathway target genes are upregulated in Equus caballus supporting limb laminitis.,2020,10.1371/journal.pone.0232920,https://pubmed.ncbi.nlm.nih.gov/33301461/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,31421125,Targeting the IL-17 Receptor Using Liposomal Spherical Nucleic Acids as Topical Therapy for Psoriasis.,2020,10.1016/j.jid.2019.06.146,https://pubmed.ncbi.nlm.nih.gov/31421125/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,34575956,Immunomodulatory Properties of Umbilical Cord Blood-Derived Small Extracellular Vesicles and Their Therapeutic Potential for Inflammatory Skin Disorders.,2021,10.3390/ijms22189797,https://pubmed.ncbi.nlm.nih.gov/34575956/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,31948839,Ex vivo culture of lesional psoriasis skin for pharmacological testing.,2020,10.1016/j.jdermsci.2019.12.010,https://pubmed.ncbi.nlm.nih.gov/31948839/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,23543857,Copy Number Variation within Human β-Defensin Gene Cluster Influences Progression to AIDS in the Multicenter AIDS Cohort Study.,2012,10.4172/2155-6113.1000184,https://pubmed.ncbi.nlm.nih.gov/23543857/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,27056267,Streptococcus pyogenes-induced cutaneous lymphocyte antigen-positive T cell-dependent epidermal cell activation triggers TH17 responses in patients with guttate psoriasis.,2016,10.1016/j.jaci.2016.02.008,https://pubmed.ncbi.nlm.nih.gov/27056267/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,27727278,Associations of Toll-Like Receptor and β-Defensin Polymorphisms with Measures of Periodontal Disease (PD) in HIV+ North American Adults: An Exploratory Study.,2016,10.1371/journal.pone.0164075,https://pubmed.ncbi.nlm.nih.gov/27727278/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,25143364,IL-32 is a molecular marker of a host defense network in human tuberculosis.,2014,10.1126/scitranslmed.3009546,https://pubmed.ncbi.nlm.nih.gov/25143364/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB104B,ENSG00000177023,Neither,11481241,Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity.,2001,10.1096/fj.00-0865fje,https://pubmed.ncbi.nlm.nih.gov/11481241/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105A,ENSG00000186562,Neither,42196916,"Evaluation of Droplet Digital PCR Assay for the Detection of Microsatellite Instability in Colorectal, Gastric, and Endometrial Cancers.",2026,10.3390/diagnostics16101550,https://pubmed.ncbi.nlm.nih.gov/42196916/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105A,ENSG00000186562,Neither,33850551,Transcriptomic analysis identifies upregulation of secreted phosphoprotein 1 in silicotic rats.,2021,10.3892/etm.2021.10011,https://pubmed.ncbi.nlm.nih.gov/33850551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105A,ENSG00000186562,Neither,30954263,"Short communication: Inhibition of DNA methyltransferase and histone deacetylase increases β-defensin expression but not the effects of lipopolysaccharide or 1,25-dihydroxyvitamin D3 in bovine mammary epithelial cells.",2019,10.3168/jds.2018-16141,https://pubmed.ncbi.nlm.nih.gov/30954263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105A,ENSG00000186562,Neither,31548051,Neutrophil β-defensin gene expression of postpartum dairy cows is altered by prepartum dietary cation-anion difference.,2019,10.3168/jds.2019-17216,https://pubmed.ncbi.nlm.nih.gov/31548051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105A,ENSG00000186562,Neither,30685825,Diversifying selection signatures among divergently selected subpopulations of Polish Red cattle.,2019,10.1007/s13353-019-00484-0,https://pubmed.ncbi.nlm.nih.gov/30685825/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105A,ENSG00000186562,Neither,33010913,Sodium butyrate promotes lipopolysaccharide-induced innate immune responses by enhancing mitogen-activated protein kinase activation and histone acetylation in bovine mammary epithelial cells.,2020,10.3168/jds.2020-18198,https://pubmed.ncbi.nlm.nih.gov/33010913/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105A,ENSG00000186562,Neither,27531713,Increased mRNA expression of selected antimicrobial peptides around ovulation and during inflammatory processes in the bovine endometrium postpartum.,2016,10.1016/j.theriogenology.2016.06.022,https://pubmed.ncbi.nlm.nih.gov/27531713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105A,ENSG00000186562,Neither,29960779,"Pegbovigrastim treatment affects gene expression in neutrophils of pasture-fed, periparturient cows.",2018,10.3168/jds.2017-14129,https://pubmed.ncbi.nlm.nih.gov/29960779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105A,ENSG00000186562,Neither,21292330,Experimental Staphylococcus aureus infection of the mammary gland induces region-specific changes in innate immune gene expression.,2011,10.1016/j.vetimm.2010.11.013,https://pubmed.ncbi.nlm.nih.gov/21292330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105A,ENSG00000186562,Neither,25574196,Genomic alterations on 8p21-p23 are the most frequent genetic events in stage I squamous cell carcinoma of the lung.,2015,10.3892/etm.2014.2123,https://pubmed.ncbi.nlm.nih.gov/25574196/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105A,ENSG00000186562,Neither,19233457,Histopathological and molecular evaluation of Holstein-Friesian cows postpartum: toward an improved understanding of uterine innate immunity.,2009,10.1016/j.theriogenology.2009.01.006,https://pubmed.ncbi.nlm.nih.gov/19233457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105A,ENSG00000186562,Neither,19889461,Divergent antimicrobial peptide (AMP) and acute phase protein (APP) responses to Trypanosoma congolense infection in trypanotolerant and trypanosusceptible cattle.,2009,10.1016/j.molimm.2009.09.042,https://pubmed.ncbi.nlm.nih.gov/19889461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105A,ENSG00000186562,Neither,32176763,High-Accuracy Determination of Microsatellite Instability Compatible with Liquid Biopsies.,2020,10.1093/clinchem/hvaa013,https://pubmed.ncbi.nlm.nih.gov/32176763/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105B,ENSG00000186599,Neither,33850551,Transcriptomic analysis identifies upregulation of secreted phosphoprotein 1 in silicotic rats.,2021,10.3892/etm.2021.10011,https://pubmed.ncbi.nlm.nih.gov/33850551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105B,ENSG00000186599,Neither,30954263,"Short communication: Inhibition of DNA methyltransferase and histone deacetylase increases β-defensin expression but not the effects of lipopolysaccharide or 1,25-dihydroxyvitamin D3 in bovine mammary epithelial cells.",2019,10.3168/jds.2018-16141,https://pubmed.ncbi.nlm.nih.gov/30954263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105B,ENSG00000186599,Neither,31548051,Neutrophil β-defensin gene expression of postpartum dairy cows is altered by prepartum dietary cation-anion difference.,2019,10.3168/jds.2019-17216,https://pubmed.ncbi.nlm.nih.gov/31548051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105B,ENSG00000186599,Neither,30685825,Diversifying selection signatures among divergently selected subpopulations of Polish Red cattle.,2019,10.1007/s13353-019-00484-0,https://pubmed.ncbi.nlm.nih.gov/30685825/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105B,ENSG00000186599,Neither,33010913,Sodium butyrate promotes lipopolysaccharide-induced innate immune responses by enhancing mitogen-activated protein kinase activation and histone acetylation in bovine mammary epithelial cells.,2020,10.3168/jds.2020-18198,https://pubmed.ncbi.nlm.nih.gov/33010913/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105B,ENSG00000186599,Neither,27531713,Increased mRNA expression of selected antimicrobial peptides around ovulation and during inflammatory processes in the bovine endometrium postpartum.,2016,10.1016/j.theriogenology.2016.06.022,https://pubmed.ncbi.nlm.nih.gov/27531713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105B,ENSG00000186599,Neither,29960779,"Pegbovigrastim treatment affects gene expression in neutrophils of pasture-fed, periparturient cows.",2018,10.3168/jds.2017-14129,https://pubmed.ncbi.nlm.nih.gov/29960779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105B,ENSG00000186599,Neither,21292330,Experimental Staphylococcus aureus infection of the mammary gland induces region-specific changes in innate immune gene expression.,2011,10.1016/j.vetimm.2010.11.013,https://pubmed.ncbi.nlm.nih.gov/21292330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105B,ENSG00000186599,Neither,19233457,Histopathological and molecular evaluation of Holstein-Friesian cows postpartum: toward an improved understanding of uterine innate immunity.,2009,10.1016/j.theriogenology.2009.01.006,https://pubmed.ncbi.nlm.nih.gov/19233457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB105B,ENSG00000186599,Neither,19889461,Divergent antimicrobial peptide (AMP) and acute phase protein (APP) responses to Trypanosoma congolense infection in trypanotolerant and trypanosusceptible cattle.,2009,10.1016/j.molimm.2009.09.042,https://pubmed.ncbi.nlm.nih.gov/19889461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB106A,ENSG00000186579,Neither,24189797,"Soluble fusion expression, characterization and localization of human β-defensin 6.",2014,10.3892/mmr.2013.1768,https://pubmed.ncbi.nlm.nih.gov/24189797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB106A,ENSG00000186579,Neither,31548051,Neutrophil β-defensin gene expression of postpartum dairy cows is altered by prepartum dietary cation-anion difference.,2019,10.3168/jds.2019-17216,https://pubmed.ncbi.nlm.nih.gov/31548051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB106A,ENSG00000186579,Neither,31404823,Region-specific gene expression in the epididymis of Yak.,2019,10.1016/j.theriogenology.2019.08.006,https://pubmed.ncbi.nlm.nih.gov/31404823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB106A,ENSG00000186579,Neither,25574196,Genomic alterations on 8p21-p23 are the most frequent genetic events in stage I squamous cell carcinoma of the lung.,2015,10.3892/etm.2014.2123,https://pubmed.ncbi.nlm.nih.gov/25574196/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB106A,ENSG00000186579,Neither,23444016,Identification of radiation-sensitive expressed genes in the ICR and AKR/J mouse thymus.,2013,10.1002/cbin.10065,https://pubmed.ncbi.nlm.nih.gov/23444016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB106A,ENSG00000186579,Neither,12600824,ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes.,2003,10.1165/rcmb.2002-0205oc,https://pubmed.ncbi.nlm.nih.gov/12600824/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB106A,ENSG00000186579,Neither,17928628,Alterations in gene expression in the caput epididymides of nonobstructive azoospermic men.,2008,10.1095/biolreprod.107.062760,https://pubmed.ncbi.nlm.nih.gov/17928628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB106B,ENSG00000187082,Neither,24189797,"Soluble fusion expression, characterization and localization of human β-defensin 6.",2014,10.3892/mmr.2013.1768,https://pubmed.ncbi.nlm.nih.gov/24189797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB106B,ENSG00000187082,Neither,31548051,Neutrophil β-defensin gene expression of postpartum dairy cows is altered by prepartum dietary cation-anion difference.,2019,10.3168/jds.2019-17216,https://pubmed.ncbi.nlm.nih.gov/31548051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB106B,ENSG00000187082,Neither,23444016,Identification of radiation-sensitive expressed genes in the ICR and AKR/J mouse thymus.,2013,10.1002/cbin.10065,https://pubmed.ncbi.nlm.nih.gov/23444016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB106B,ENSG00000187082,Neither,12600824,ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes.,2003,10.1165/rcmb.2002-0205oc,https://pubmed.ncbi.nlm.nih.gov/12600824/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107A,ENSG00000186572,Neither,31548051,Neutrophil β-defensin gene expression of postpartum dairy cows is altered by prepartum dietary cation-anion difference.,2019,10.3168/jds.2019-17216,https://pubmed.ncbi.nlm.nih.gov/31548051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107A,ENSG00000186572,Neither,35111692,Exogenous Vitamin D3 Modulates Response of Bovine Macrophages to Mycobacterium avium subsp. paratuberculosis Infection and Is Dependent Upon Stage of Johne's Disease.,2021,10.3389/fcimb.2021.773938,https://pubmed.ncbi.nlm.nih.gov/35111692/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107A,ENSG00000186572,Neither,36001276,Unrevealing functional candidate genes for bovine fertility through RNA sequencing meta-analysis and regulatory elements networks of co-expressed genes and lncRNAs.,2022,10.1007/s10142-022-00893-1,https://pubmed.ncbi.nlm.nih.gov/36001276/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107A,ENSG00000186572,Neither,34146201,Global transcriptomic profiles of circulating leucocytes in early lactation cows with clinical or subclinical mastitis.,2021,10.1007/s11033-021-06494-8,https://pubmed.ncbi.nlm.nih.gov/34146201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107A,ENSG00000186572,Neither,30954263,"Short communication: Inhibition of DNA methyltransferase and histone deacetylase increases β-defensin expression but not the effects of lipopolysaccharide or 1,25-dihydroxyvitamin D3 in bovine mammary epithelial cells.",2019,10.3168/jds.2018-16141,https://pubmed.ncbi.nlm.nih.gov/30954263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107A,ENSG00000186572,Neither,28229929,"Intramammary 1,25-dihydroxyvitamin D3 treatment increases expression of host-defense genes in mammary immune cells of lactating dairy cattle.",2017,10.1016/j.jsbmb.2017.02.006,https://pubmed.ncbi.nlm.nih.gov/28229929/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107A,ENSG00000186572,Neither,30685825,Diversifying selection signatures among divergently selected subpopulations of Polish Red cattle.,2019,10.1007/s13353-019-00484-0,https://pubmed.ncbi.nlm.nih.gov/30685825/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107A,ENSG00000186572,Neither,32747107,Changes in expression of antimicrobial peptides and Fc receptors in the small intestines of neonatal calves during the passive immunity period.,2020,10.3168/jds.2019-18113,https://pubmed.ncbi.nlm.nih.gov/32747107/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107A,ENSG00000186572,Neither,24552181,Narrowing down the distal border of the copy number variable beta-defensin gene cluster on human 8p23.,2014,10.1186/1756-0500-7-93,https://pubmed.ncbi.nlm.nih.gov/24552181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107A,ENSG00000186572,Neither,24867293,Copy number variation of the beta defensin gene cluster on chromosome 8p influences the bacterial microbiota within the nasopharynx of otitis-prone children.,2014,10.1371/journal.pone.0098269,https://pubmed.ncbi.nlm.nih.gov/24867293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107A,ENSG00000186572,Neither,29753474,Intramammary 25-hydroxyvitamin D3 treatment modulates innate immune responses to endotoxin-induced mastitis.,2018,10.3168/jds.2017-14143,https://pubmed.ncbi.nlm.nih.gov/29753474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107B,ENSG00000198129,Neither,31548051,Neutrophil β-defensin gene expression of postpartum dairy cows is altered by prepartum dietary cation-anion difference.,2019,10.3168/jds.2019-17216,https://pubmed.ncbi.nlm.nih.gov/31548051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107B,ENSG00000198129,Neither,35111692,Exogenous Vitamin D3 Modulates Response of Bovine Macrophages to Mycobacterium avium subsp. paratuberculosis Infection and Is Dependent Upon Stage of Johne's Disease.,2021,10.3389/fcimb.2021.773938,https://pubmed.ncbi.nlm.nih.gov/35111692/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107B,ENSG00000198129,Neither,36001276,Unrevealing functional candidate genes for bovine fertility through RNA sequencing meta-analysis and regulatory elements networks of co-expressed genes and lncRNAs.,2022,10.1007/s10142-022-00893-1,https://pubmed.ncbi.nlm.nih.gov/36001276/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107B,ENSG00000198129,Neither,34146201,Global transcriptomic profiles of circulating leucocytes in early lactation cows with clinical or subclinical mastitis.,2021,10.1007/s11033-021-06494-8,https://pubmed.ncbi.nlm.nih.gov/34146201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107B,ENSG00000198129,Neither,30954263,"Short communication: Inhibition of DNA methyltransferase and histone deacetylase increases β-defensin expression but not the effects of lipopolysaccharide or 1,25-dihydroxyvitamin D3 in bovine mammary epithelial cells.",2019,10.3168/jds.2018-16141,https://pubmed.ncbi.nlm.nih.gov/30954263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107B,ENSG00000198129,Neither,28229929,"Intramammary 1,25-dihydroxyvitamin D3 treatment increases expression of host-defense genes in mammary immune cells of lactating dairy cattle.",2017,10.1016/j.jsbmb.2017.02.006,https://pubmed.ncbi.nlm.nih.gov/28229929/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107B,ENSG00000198129,Neither,30685825,Diversifying selection signatures among divergently selected subpopulations of Polish Red cattle.,2019,10.1007/s13353-019-00484-0,https://pubmed.ncbi.nlm.nih.gov/30685825/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107B,ENSG00000198129,Neither,32747107,Changes in expression of antimicrobial peptides and Fc receptors in the small intestines of neonatal calves during the passive immunity period.,2020,10.3168/jds.2019-18113,https://pubmed.ncbi.nlm.nih.gov/32747107/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107B,ENSG00000198129,Neither,24552181,Narrowing down the distal border of the copy number variable beta-defensin gene cluster on human 8p23.,2014,10.1186/1756-0500-7-93,https://pubmed.ncbi.nlm.nih.gov/24552181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107B,ENSG00000198129,Neither,24867293,Copy number variation of the beta defensin gene cluster on chromosome 8p influences the bacterial microbiota within the nasopharynx of otitis-prone children.,2014,10.1371/journal.pone.0098269,https://pubmed.ncbi.nlm.nih.gov/24867293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB107B,ENSG00000198129,Neither,29753474,Intramammary 25-hydroxyvitamin D3 treatment modulates innate immune responses to endotoxin-induced mastitis.,2018,10.3168/jds.2017-14143,https://pubmed.ncbi.nlm.nih.gov/29753474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB110,ENSG00000203970,Neither,38145478,Abundance of selected genes implicated in testicular functions in Camelus dromedarius with high and low epididymal semen quality.,2024,10.1093/biolre/ioad177,https://pubmed.ncbi.nlm.nih.gov/38145478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB110,ENSG00000203970,Neither,39031030,Region-specific gene expression profile in the epididymis of high- and low-fertile dromedary camels.,2024,10.1111/rda.14678,https://pubmed.ncbi.nlm.nih.gov/39031030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB110,ENSG00000203970,Neither,31548051,Neutrophil β-defensin gene expression of postpartum dairy cows is altered by prepartum dietary cation-anion difference.,2019,10.3168/jds.2019-17216,https://pubmed.ncbi.nlm.nih.gov/31548051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB110,ENSG00000203970,Neither,38110290,"1,25-Dihydroxyvitamin D3 potentiates the innate immune response of peripheral blood mononuclear cells from Japanese Black cattle.",2023,10.1111/asj.13906,https://pubmed.ncbi.nlm.nih.gov/38110290/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB110,ENSG00000203970,Neither,34146201,Global transcriptomic profiles of circulating leucocytes in early lactation cows with clinical or subclinical mastitis.,2021,10.1007/s11033-021-06494-8,https://pubmed.ncbi.nlm.nih.gov/34146201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB110,ENSG00000203970,Neither,28542507,Establishment a real-time reverse transcription PCR based on host biomarkers for the detection of the subclinical cases of Mycobacterium avium subsp. paratuberculosis.,2017,10.1371/journal.pone.0178336,https://pubmed.ncbi.nlm.nih.gov/28542507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB110,ENSG00000203970,Neither,30954263,"Short communication: Inhibition of DNA methyltransferase and histone deacetylase increases β-defensin expression but not the effects of lipopolysaccharide or 1,25-dihydroxyvitamin D3 in bovine mammary epithelial cells.",2019,10.3168/jds.2018-16141,https://pubmed.ncbi.nlm.nih.gov/30954263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB110,ENSG00000203970,Neither,30685825,Diversifying selection signatures among divergently selected subpopulations of Polish Red cattle.,2019,10.1007/s13353-019-00484-0,https://pubmed.ncbi.nlm.nih.gov/30685825/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB110,ENSG00000203970,Neither,32747107,Changes in expression of antimicrobial peptides and Fc receptors in the small intestines of neonatal calves during the passive immunity period.,2020,10.3168/jds.2019-18113,https://pubmed.ncbi.nlm.nih.gov/32747107/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB110,ENSG00000203970,Neither,29753474,Intramammary 25-hydroxyvitamin D3 treatment modulates innate immune responses to endotoxin-induced mastitis.,2018,10.3168/jds.2017-14143,https://pubmed.ncbi.nlm.nih.gov/29753474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB110,ENSG00000203970,Neither,28109589,Effects of precalving body condition and prepartum feeding level on gene expression in circulating neutrophils.,2017,10.3168/jds.2016-12105,https://pubmed.ncbi.nlm.nih.gov/28109589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB110,ENSG00000203970,Neither,21955788,Identifying Tmem59 related gene regulatory network of mouse neural stem cell from a compendium of expression profiles.,2011,10.1186/1752-0509-5-152,https://pubmed.ncbi.nlm.nih.gov/21955788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB110,ENSG00000203970,Neither,27179873,Parturition in dairy cows temporarily alters the expression of genes in circulating neutrophils.,2016,10.3168/jds.2015-10877,https://pubmed.ncbi.nlm.nih.gov/27179873/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB110,ENSG00000203970,Neither,20372808,Characterization of changes in global gene expression in the brain of neuron-specific enolase/human Tau23 transgenic mice in response to overexpression of Tau protein.,2010,10.3892/ijmm_00000390,https://pubmed.ncbi.nlm.nih.gov/20372808/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,38484587,DEFB114 protein enhances host resistance to fungal infection through the NOD1/2-ATG16L1-NF-κB signaling pathway.,2024,10.1016/j.bioorg.2024.107245,https://pubmed.ncbi.nlm.nih.gov/38484587/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,38757095,The Role of Aryl Hydrocarbon Receptor in Bone Biology.,2024,10.1177/11786469241246674,https://pubmed.ncbi.nlm.nih.gov/38757095/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,39944873,Nomogram construction based on characteristic genes and clinical variables to predict the risk of multiple organ dysfunction syndrome caused by influenza in children.,2025,10.21037/tp-24-386,https://pubmed.ncbi.nlm.nih.gov/39944873/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,39781190,Aged garlic extract enhances the production of β‑defensin 4 via activation of the Wnt/β‑catenin pathway in mouse gingiva.,2025,10.3892/etm.2024.12791,https://pubmed.ncbi.nlm.nih.gov/39781190/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,33131146,Expression of antimicrobial peptide genes oscillates along day/night rhythm protecting mice skin from bacteria.,2021,10.1111/exd.14229,https://pubmed.ncbi.nlm.nih.gov/33131146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,31007462,Proteins as the Molecular Markers of Male Fertility.,2019,10.4103/jhrs.jhrs_9_18,https://pubmed.ncbi.nlm.nih.gov/31007462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,31962226,Functional characterization of NLRX1 in rabbit during enterohemorrhagic Escherichia coli infection.,2020,10.1016/j.dci.2020.103612,https://pubmed.ncbi.nlm.nih.gov/31962226/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,23482568,The novel human β-defensin 114 regulates lipopolysaccharide (LPS)-mediated inflammation and protects sperm from motility loss.,2013,10.1074/jbc.m112.411884,https://pubmed.ncbi.nlm.nih.gov/23482568/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,30524393,Evaluating the Value of Defensins for Diagnosing Secondary Bacterial Infections in Influenza-Infected Patients.,2018,10.3389/fmicb.2018.02762,https://pubmed.ncbi.nlm.nih.gov/30524393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,27442430,Activation of Molecular Signatures for Antimicrobial and Innate Defense Responses in Skin with Transglutaminase 1 Deficiency.,2016,10.1371/journal.pone.0159673,https://pubmed.ncbi.nlm.nih.gov/27442430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,29723492,Microbial Host Interactions and Impaired Wound Healing in Mice and Humans: Defining a Role for BD14 and NOD2.,2018,10.1016/j.jid.2018.04.014,https://pubmed.ncbi.nlm.nih.gov/29723492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,22504651,Mouse β-defensin 14 (Defb14) promotes tumor growth by inducing angiogenesis in a CCR6-dependent manner.,2012,10.4049/jimmunol.1102442,https://pubmed.ncbi.nlm.nih.gov/22504651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,24204930,Expression and antimicrobial function of beta-defensin 1 in the lower urinary tract.,2013,10.1371/journal.pone.0077714,https://pubmed.ncbi.nlm.nih.gov/24204930/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,26702876,Lipocalin-2 exacerbates psoriasiform skin inflammation by augmenting T-helper 17 response.,2016,10.1111/1346-8138.13227,https://pubmed.ncbi.nlm.nih.gov/26702876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,18180295,Analysis and separation of residues important for the chemoattractant and antimicrobial activities of beta-defensin 3.,2008,10.1074/jbc.m709238200,https://pubmed.ncbi.nlm.nih.gov/18180295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,23332217,Beta-defensins activate macrophages and synergize in pro-inflammatory cytokine expression induced by TLR ligands.,2013,10.1016/j.imbio.2012.11.007,https://pubmed.ncbi.nlm.nih.gov/23332217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,20176896,Peptide fragments of a beta-defensin derivative with potent bactericidal activity.,2010,10.1128/aac.01568-09,https://pubmed.ncbi.nlm.nih.gov/20176896/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,20104491,Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo.,2010,10.1002/eji.200940041,https://pubmed.ncbi.nlm.nih.gov/20104491/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,18167348,"Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3.",2008,10.1074/jbc.m709103200,https://pubmed.ncbi.nlm.nih.gov/18167348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB114,ENSG00000177684,Neither,15908390,Antimicrobial activity of murine lung cells against Staphylococcus aureus is increased in vitro and in vivo after elafin gene transfer.,2005,10.1128/iai.73.6.3609-3617.2005,https://pubmed.ncbi.nlm.nih.gov/15908390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB118,ENSG00000131068,Neither,41002397,Morphological and Transcriptomic Analyses of the Adrenal Gland in &lt;i&gt;Acomys cahirinus&lt;/i&gt;: A Novel Model for Murine Adrenal Physiology.,2025,10.3390/cells14181431,https://pubmed.ncbi.nlm.nih.gov/41002397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB118,ENSG00000131068,Neither,38745232,Single-cell and spatial transcriptomic investigation reveals the spatiotemporal specificity of the beta-defensin gene family during mouse sperm maturation.,2024,10.1186/s12964-024-01637-3,https://pubmed.ncbi.nlm.nih.gov/38745232/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB118,ENSG00000131068,Neither,35507985,"Expression of anti-fungal peptide, β-defensin 118 in oral fibroblasts induced by C. albicans β-glucan-containing particles.",2022,10.1590/1678-7757-2021-0321,https://pubmed.ncbi.nlm.nih.gov/35507985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB118,ENSG00000131068,Neither,35440001,β-defensin 118 attenuates inflammation and injury of intestinal epithelial cells upon enterotoxigenic Escherichia coli challenge.,2022,10.1186/s12917-022-03242-3,https://pubmed.ncbi.nlm.nih.gov/35440001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB118,ENSG00000131068,Neither,33185791,Human β-Defensin 118 Attenuates Escherichia coli K88-Induced Inflammation and Intestinal Injury in Mice.,2021,10.1007/s12602-020-09725-9,https://pubmed.ncbi.nlm.nih.gov/33185791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB118,ENSG00000131068,Neither,33224970,Expression and Functional Characterization of a Novel Antimicrobial Peptide: Human Beta-Defensin 118.,2020,10.1155/2020/1395304,https://pubmed.ncbi.nlm.nih.gov/33224970/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB118,ENSG00000131068,Neither,33181266,The truncated human beta-defensin 118 can modulate lipopolysaccharide mediated inflammatory response in RAW264.7 macrophages.,2021,10.1016/j.peptides.2020.170438,https://pubmed.ncbi.nlm.nih.gov/33181266/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB118,ENSG00000131068,Neither,27187330,Identification of New Epididymal Luminal Fluid Proteins Involved in Sperm Maturation in Infertile Rats Treated by Dutasteride Using iTRAQ.,2016,10.3390/molecules21050602,https://pubmed.ncbi.nlm.nih.gov/27187330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB118,ENSG00000131068,Neither,27897040,Identification of novel genes by whole-exome sequencing can improve gastric cancer precision oncology.,2017,10.2217/fon-2016-0430,https://pubmed.ncbi.nlm.nih.gov/27897040/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB118,ENSG00000131068,Neither,25099571,Androgenic regulation of beta-defensins in the mouse epididymis.,2014,10.1186/1477-7827-12-76,https://pubmed.ncbi.nlm.nih.gov/25099571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB118,ENSG00000131068,Neither,15755028,[Expression and biology identification of the human epididymis-specific gene ESC42 in E. coli].,2005,,https://pubmed.ncbi.nlm.nih.gov/15755028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB118,ENSG00000131068,Neither,11564719,"Primate epididymis-specific proteins: characterization of ESC42, a novel protein containing a trefoil-like motif in monkey and human.",2001,10.1210/endo.142.10.8422,https://pubmed.ncbi.nlm.nih.gov/11564719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB118,ENSG00000131068,Neither,12600824,ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes.,2003,10.1165/rcmb.2002-0205oc,https://pubmed.ncbi.nlm.nih.gov/12600824/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB121,ENSG00000204548,Neither,39694081,Single-cell RNA sequencing unveils dynamic transcriptional profiles during the process of donkey spermatogenesis and maturation.,2025,10.1016/j.ygeno.2024.110974,https://pubmed.ncbi.nlm.nih.gov/39694081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB121,ENSG00000204548,Neither,36368116,Comparative transcriptome analysis in the caput segment of yak and cattleyak epididymis.,2023,10.1016/j.theriogenology.2022.10.039,https://pubmed.ncbi.nlm.nih.gov/36368116/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB121,ENSG00000204548,Neither,16457734,"Identification, cloning and functional characterization of novel beta-defensins in the rat (Rattus norvegicus).",2006,10.1186/1477-7827-4-7,https://pubmed.ncbi.nlm.nih.gov/16457734/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB121,ENSG00000204548,Neither,15772680,"Identification, characterization, and evolution of a primate beta-defensin gene cluster.",2005,10.1038/sj.gene.6364184,https://pubmed.ncbi.nlm.nih.gov/15772680/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB125,ENSG00000178591,Neither,42707141,"A stromal β-defensin, DEFB124, contributes to cutaneous host defense against &lt;i&gt;Staphylococcus aureus&lt;/i&gt;.",2026,10.1016/j.isci.2026.117306,https://pubmed.ncbi.nlm.nih.gov/42707141/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB125,ENSG00000178591,Neither,38745232,Single-cell and spatial transcriptomic investigation reveals the spatiotemporal specificity of the beta-defensin gene family during mouse sperm maturation.,2024,10.1186/s12964-024-01637-3,https://pubmed.ncbi.nlm.nih.gov/38745232/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB125,ENSG00000178591,Neither,39127975,Genetic Features of Tongue Cancer Recurrence in Young Adults.,2024,10.1007/s10517-024-06189-7,https://pubmed.ncbi.nlm.nih.gov/39127975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB125,ENSG00000178591,Neither,38135080,Maternal urban particulate matter (SRM 1648a) exposure disrupted the cellular immune homeostasis during early life: The potential attribution of altered placental transcriptome profile.,2024,10.1016/j.scitotenv.2023.169432,https://pubmed.ncbi.nlm.nih.gov/38135080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB125,ENSG00000178591,Neither,31962226,Functional characterization of NLRX1 in rabbit during enterohemorrhagic Escherichia coli infection.,2020,10.1016/j.dci.2020.103612,https://pubmed.ncbi.nlm.nih.gov/31962226/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB125,ENSG00000178591,Neither,29998088,Protective Role of Rabbit Nucleotide-Binding Oligomerization Domain-2 (NOD2)-Mediated Signaling Pathway in Resistance to Enterohemorrhagic Escherichia coli Infection.,2018,10.3389/fcimb.2018.00220,https://pubmed.ncbi.nlm.nih.gov/29998088/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB125,ENSG00000178591,Neither,29067026,Characterization of Rabbit Nucleotide-Binding Oligomerization Domain 1 (NOD1) and the Role of NOD1 Signaling Pathway during Bacterial Infection.,2017,10.3389/fimmu.2017.01278,https://pubmed.ncbi.nlm.nih.gov/29067026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB125,ENSG00000178591,Neither,31404823,Region-specific gene expression in the epididymis of Yak.,2019,10.1016/j.theriogenology.2019.08.006,https://pubmed.ncbi.nlm.nih.gov/31404823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB125,ENSG00000178591,Neither,25099571,Androgenic regulation of beta-defensins in the mouse epididymis.,2014,10.1186/1477-7827-12-76,https://pubmed.ncbi.nlm.nih.gov/25099571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB125,ENSG00000178591,Neither,12620395,Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis.,2003,10.1016/s0888-7543(02)00034-4,https://pubmed.ncbi.nlm.nih.gov/12620395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB127,ENSG00000088782,Neither,39127975,Genetic Features of Tongue Cancer Recurrence in Young Adults.,2024,10.1007/s10517-024-06189-7,https://pubmed.ncbi.nlm.nih.gov/39127975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB127,ENSG00000088782,Neither,32077919,Genome-wide association study on coronary artery disease in type 1 diabetes suggests beta-defensin 127 as a risk locus.,2021,10.1093/cvr/cvaa045,https://pubmed.ncbi.nlm.nih.gov/32077919/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB127,ENSG00000088782,Neither,32030088,Comparative RNA-Seq Analysis of Differentially Expressed Genes in the Epididymides of Yak and Cattleyak.,2019,10.2174/1389202920666190809092819,https://pubmed.ncbi.nlm.nih.gov/32030088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB127,ENSG00000088782,Neither,30524393,Evaluating the Value of Defensins for Diagnosing Secondary Bacterial Infections in Influenza-Infected Patients.,2018,10.3389/fmicb.2018.02762,https://pubmed.ncbi.nlm.nih.gov/30524393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB127,ENSG00000088782,Neither,29351916,Pathways Impacted by Genomic Alterations in Pulmonary Carcinoid Tumors.,2018,10.1158/1078-0432.ccr-17-0252,https://pubmed.ncbi.nlm.nih.gov/29351916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB127,ENSG00000088782,Neither,16457734,"Identification, cloning and functional characterization of novel beta-defensins in the rat (Rattus norvegicus).",2006,10.1186/1477-7827-4-7,https://pubmed.ncbi.nlm.nih.gov/16457734/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB127,ENSG00000088782,Neither,18416833,Directional and balancing selection in human beta-defensins.,2008,10.1186/1471-2148-8-113,https://pubmed.ncbi.nlm.nih.gov/18416833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB128,ENSG00000185982,Neither,40299566,Exploring the Role of Inflammation and Metabolites in Bell's Palsy and Potential Treatment Strategies.,2025,10.3390/biomedicines13040957,https://pubmed.ncbi.nlm.nih.gov/40299566/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB128,ENSG00000185982,Neither,39127975,Genetic Features of Tongue Cancer Recurrence in Young Adults.,2024,10.1007/s10517-024-06189-7,https://pubmed.ncbi.nlm.nih.gov/39127975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB128,ENSG00000185982,Neither,35330821,Gingival Transcriptome of Innate Antimicrobial Factors and the Oral Microbiome With Aging and Periodontitis.,2022,10.3389/froh.2022.817249,https://pubmed.ncbi.nlm.nih.gov/35330821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB128,ENSG00000185982,Neither,32030088,Comparative RNA-Seq Analysis of Differentially Expressed Genes in the Epididymides of Yak and Cattleyak.,2019,10.2174/1389202920666190809092819,https://pubmed.ncbi.nlm.nih.gov/32030088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB128,ENSG00000185982,Neither,29998088,Protective Role of Rabbit Nucleotide-Binding Oligomerization Domain-2 (NOD2)-Mediated Signaling Pathway in Resistance to Enterohemorrhagic Escherichia coli Infection.,2018,10.3389/fcimb.2018.00220,https://pubmed.ncbi.nlm.nih.gov/29998088/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB128,ENSG00000185982,Neither,29067026,Characterization of Rabbit Nucleotide-Binding Oligomerization Domain 1 (NOD1) and the Role of NOD1 Signaling Pathway during Bacterial Infection.,2017,10.3389/fimmu.2017.01278,https://pubmed.ncbi.nlm.nih.gov/29067026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,42468944,Robust Scoring System to Evaluate Animal Well-Being in Murine (Mus musculus) Orthotopic Breast Cancer and Ovarian Cancer Models.,2026,10.30802/aalas-jaalas-26-027,https://pubmed.ncbi.nlm.nih.gov/42468944/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,42238569,Fucosyltransferase 4-derived peptide bioconjugates on carbon nanotubes enhance antitumor immunity in an ovarian cancer mouse model.,2026,10.3389/fimmu.2026.1821727,https://pubmed.ncbi.nlm.nih.gov/42238569/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,39612052,Imaging tumor and ascites-associated macrophages in a mouse model of metastatic ovarian cancer.,2024,10.1186/s13550-024-01157-8,https://pubmed.ncbi.nlm.nih.gov/39612052/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,40447608,A cowpea mosaic virus adjuvant conjugated to liposomes loaded with tumor cell lysates as an ovarian cancer vaccine.,2025,10.1038/s41467-025-60239-w,https://pubmed.ncbi.nlm.nih.gov/40447608/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,39634576,Combination of cowpea mosaic virus (CPMV) intratumoral therapy and oxaliplatin chemotherapy.,2024,10.1039/d4ma00427b,https://pubmed.ncbi.nlm.nih.gov/39634576/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,39127975,Genetic Features of Tongue Cancer Recurrence in Young Adults.,2024,10.1007/s10517-024-06189-7,https://pubmed.ncbi.nlm.nih.gov/39127975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,35158887,PD-L1 near Infrared Photoimmunotherapy of Ovarian Cancer Model.,2022,10.3390/cancers14030619,https://pubmed.ncbi.nlm.nih.gov/35158887/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,36053908,Cisplatin-Loaded Tobacco Mosaic Virus for Ovarian Cancer Treatment.,2022,10.1021/acs.biomac.2c00831,https://pubmed.ncbi.nlm.nih.gov/36053908/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,36352091,Analysis of amplification and association polymorphisms in the bovine beta-defensin 129 (BBD129) gene revealed its function in bull fertility.,2022,10.1038/s41598-022-23654-3,https://pubmed.ncbi.nlm.nih.gov/36352091/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,35507985,"Expression of anti-fungal peptide, β-defensin 118 in oral fibroblasts induced by C. albicans β-glucan-containing particles.",2022,10.1590/1678-7757-2021-0321,https://pubmed.ncbi.nlm.nih.gov/35507985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,32030088,Comparative RNA-Seq Analysis of Differentially Expressed Genes in the Epididymides of Yak and Cattleyak.,2019,10.2174/1389202920666190809092819,https://pubmed.ncbi.nlm.nih.gov/32030088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,25946105,"Identification of CTLA2A, DEFB29, WFDC15B, SERPINA1F and MUP19 as Novel Tissue-Specific Secretory Factors in Mouse.",2015,10.1371/journal.pone.0124962,https://pubmed.ncbi.nlm.nih.gov/25946105/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,29430218,Metabolomic characterization of experimental ovarian cancer ascitic fluid.,2017,10.1007/s11306-017-1254-3,https://pubmed.ncbi.nlm.nih.gov/29430218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,23765988,A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis.,2014,10.1002/jcp.24418,https://pubmed.ncbi.nlm.nih.gov/23765988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,29732445,Radiation Therapy Combined with Cowpea Mosaic Virus Nanoparticle in Situ Vaccination Initiates Immune-Mediated Tumor Regression.,2018,10.1021/acsomega.8b00227,https://pubmed.ncbi.nlm.nih.gov/29732445/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,33969181,Cowpea Mosaic Virus Promotes Anti-Tumor Activity and Immune Memory in a Mouse Ovarian Tumor Model.,2019,10.1002/adtp.201900003,https://pubmed.ncbi.nlm.nih.gov/33969181/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,31375592,Cowpea Mosaic Virus Nanoparticles and Empty Virus-Like Particles Show Distinct but Overlapping Immunostimulatory Properties.,2019,10.1128/jvi.00129-19,https://pubmed.ncbi.nlm.nih.gov/31375592/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,31362778,Combination therapy targeting both innate and adaptive immunity improves survival in a pre-clinical model of ovarian cancer.,2019,10.1186/s40425-019-0654-5,https://pubmed.ncbi.nlm.nih.gov/31362778/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,25083323,Attenuated Listeria monocytogenes reprograms M2-polarized tumor-associated macrophages in ovarian cancer leading to iNOS-mediated tumor cell lysis.,2014,10.4161/onci.28926,https://pubmed.ncbi.nlm.nih.gov/25083323/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,17581599,Control of human mesothelin-expressing tumors by DNA vaccines.,2007,10.1038/sj.gt.3302974,https://pubmed.ncbi.nlm.nih.gov/17581599/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,23704211,Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment.,2013,10.1158/0008-5472.can-12-1974,https://pubmed.ncbi.nlm.nih.gov/23704211/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB129,ENSG00000125903,Neither,12600824,ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes.,2003,10.1165/rcmb.2002-0205oc,https://pubmed.ncbi.nlm.nih.gov/12600824/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB130A,ENSG00000232948,Neither,40682483,Genetic Loci Associated With Periodontitis: The FinnGen Study Based on National Health Registers.,2025,10.1111/jcpe.14193,https://pubmed.ncbi.nlm.nih.gov/40682483/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB130A,ENSG00000232948,Neither,28181499,Involvement of β-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum.,2017,10.1038/srep41772,https://pubmed.ncbi.nlm.nih.gov/28181499/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB130B,ENSG00000233050,Neither,28181499,Involvement of β-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum.,2017,10.1038/srep41772,https://pubmed.ncbi.nlm.nih.gov/28181499/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB135,ENSG00000205883,Neither,42384160,Bidirectional mendelian randomization identifies plasma proteins associated with cervical cancer risk.,2026,10.1186/s43046-026-00374-7,https://pubmed.ncbi.nlm.nih.gov/42384160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB135,ENSG00000205883,Neither,40468462,"SPAG11B, a potential biomarker for rheumatoid arthritis: a two-sample bidirectional Mendelian randomization analysis.",2025,10.1186/s41927-025-00521-y,https://pubmed.ncbi.nlm.nih.gov/40468462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB135,ENSG00000205883,Neither,40629581,Causal relationships between 4907 circulating proteins and heart failure and atrial fibrillation: A bidirectional Mendelian randomization study.,2025,10.1097/md.0000000000043198,https://pubmed.ncbi.nlm.nih.gov/40629581/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB135,ENSG00000205883,Neither,40002435,Genome-Wide Association Study of Exercise Addiction Among Elite Wrestlers.,2025,10.3390/brainsci15020102,https://pubmed.ncbi.nlm.nih.gov/40002435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB135,ENSG00000205883,Neither,29067026,Characterization of Rabbit Nucleotide-Binding Oligomerization Domain 1 (NOD1) and the Role of NOD1 Signaling Pathway during Bacterial Infection.,2017,10.3389/fimmu.2017.01278,https://pubmed.ncbi.nlm.nih.gov/29067026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,41634710,DMBX1 expression in colon cancer and its impact on prognosis and the tumor microenvironment.,2026,10.1186/s12920-026-02320-x,https://pubmed.ncbi.nlm.nih.gov/41634710/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,42229817,DMBX1 facilitates tumor progression via triggering epithelial-mesenchymal transition and cancer cell stemness mediated by DMBX1/PAX2/SOX5 axis in prostate cancer cells.,2026,10.1016/j.yexcr.2026.115094,https://pubmed.ncbi.nlm.nih.gov/42229817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,42392557,The sepD5 mutation of Aspergillus nidulans localizes to a gene encoding a LIM domain protein required for contractile ring constriction and recruitment of key septation proteins.,2026,10.1016/j.fgb.2026.104093,https://pubmed.ncbi.nlm.nih.gov/42392557/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,41922954,A role for PaxB in regulating blebbing: experimental insights and theoretical perspectives from Dictyostelium discoideum.,2026,10.1186/s12860-026-00584-w,https://pubmed.ncbi.nlm.nih.gov/41922954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,40377162,A Neuroendocrine Differentiation-related Molecular Model for Prognosis Prediction in Prostate Cancer Patients.,2026,10.2174/0109298673362568250505074520,https://pubmed.ncbi.nlm.nih.gov/40377162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,41422989,"The homeobox gene, dmbx1a, is required for the development and maintenance of bipolar and photoreceptor cells in the zebrafish retina.",2026,10.1016/j.exer.2025.110809,https://pubmed.ncbi.nlm.nih.gov/41422989/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,40096956,A gene regulatory network for specification and morphogenesis of a Mauthner Cell homolog in non-vertebrate chordates.,2025,10.1016/j.ydbio.2025.03.007,https://pubmed.ncbi.nlm.nih.gov/40096956/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,39234977,Serum Circulating mRNA Panel for the Early Detection of Gastric Cancer: A Potential Biomarker Test.,2024,10.1002/cmdc.202400523,https://pubmed.ncbi.nlm.nih.gov/39234977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,38658591,A multi-omics analysis-based model to predict the prognosis of low-grade gliomas.,2024,10.1038/s41598-024-58434-8,https://pubmed.ncbi.nlm.nih.gov/38658591/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,33524552,Roles of diencephalon/mesencephalon homeobox 1 in the development and prognosis of hepatocellular carcinoma.,2021,10.1016/j.aohep.2021.100314,https://pubmed.ncbi.nlm.nih.gov/33524552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,32317285,The Scaffold Proteins Paxillin B and α-Actinin Regulate Septation in Aspergillus nidulans via Control of Actin Ring Contraction.,2020,10.1534/genetics.120.303234,https://pubmed.ncbi.nlm.nih.gov/32317285/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,31481972,miRNA-mRNA Associated With Survival in Endometrial Cancer.,2019,10.3389/fgene.2019.00743,https://pubmed.ncbi.nlm.nih.gov/31481972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,26505115,Importance of Adult Dmbx1 in Long-Lasting Orexigenic Effect of Agouti-Related Peptide.,2016,10.1210/en.2015-1560,https://pubmed.ncbi.nlm.nih.gov/26505115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,30928384,DMBX1 promotes tumor proliferation and regulates cell cycle progression via repressing OTX2-mediated transcription of p21 in lung adenocarcinoma cell.,2019,10.1016/j.canlet.2019.03.045,https://pubmed.ncbi.nlm.nih.gov/30928384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,35046895,"qPCR Analysis Reveals Association of Differential Expression of SRR, NFKB1, and PDE4B Genes With Type 2 Diabetes Mellitus.",2021,10.3389/fendo.2021.774696,https://pubmed.ncbi.nlm.nih.gov/35046895/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,30794564,"Secreted frizzled related protein is a target of PaxB and plays a role in aquiferous system development in the freshwater sponge, Ephydatia muelleri.",2019,10.1371/journal.pone.0212005,https://pubmed.ncbi.nlm.nih.gov/30794564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,36757299,MYC/Glutamine Dependency Is a Therapeutic Vulnerability in Pancreatic Cancer with Deoxycytidine Kinase Inactivation-Induced Gemcitabine Resistance.,2023,10.1158/1541-7786.mcr-22-0554,https://pubmed.ncbi.nlm.nih.gov/36757299/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,33675014,NMR resonance assignments for a docking domain pair with an attached thiolation domain from the PAX peptide-producing NRPS from Xenorhabdus cabanillasii.,2021,10.1007/s12104-021-10010-1,https://pubmed.ncbi.nlm.nih.gov/33675014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,33456446,Exploiting the Autozygome to Support Previously Published Mendelian Gene-Disease Associations: An Update.,2020,10.3389/fgene.2020.580484,https://pubmed.ncbi.nlm.nih.gov/33456446/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,15890343,Functional analysis of transcriptional repressor Otx3/Dmbx1.,2005,10.1016/j.febslet.2005.04.042,https://pubmed.ncbi.nlm.nih.gov/15890343/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMBX1,ENSG00000197587,Neither,27980695,Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis.,2016,10.1186/s13148-016-0297-z,https://pubmed.ncbi.nlm.nih.gov/27980695/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTC2,ENSG00000142025,Neither,41411337,Contrasting effects of DNA demethylation on cancer-germline gene expression in breast cancer and leukemia cells.,2025,10.1371/journal.pone.0339460,https://pubmed.ncbi.nlm.nih.gov/41411337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTC2,ENSG00000142025,Neither,42450712,Transcriptomic Profiling of Canine Testicular Leydig Cell Tumors Uncovers Key Upregulated Gene Pathways.,2026,10.3390/ani16132005,https://pubmed.ncbi.nlm.nih.gov/42450712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTC2,ENSG00000142025,Neither,41214474,Compound heterozygous variants of the DMRTC2 gene are associated with non-obstructive azoospermia in a patient.,2026,10.4103/aja202573,https://pubmed.ncbi.nlm.nih.gov/41214474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTC2,ENSG00000142025,Neither,39208330,"Differential expression and regulation of ADAD1, DMRTC2, PRSS54, SYCE1, SYCP1, TEX101, TEX48, and TMPRSS12 gene profiles in colon cancer tissues and their in vitro response to epigenetic drugs.",2024,10.1371/journal.pone.0307724,https://pubmed.ncbi.nlm.nih.gov/39208330/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTC2,ENSG00000142025,Neither,32244802,"Cloning, Molecular Characterization and Expression Patterns of DMRTC2 Implicated in Germ Cell Development of Male Tibetan Sheep.",2020,10.3390/ijms21072448,https://pubmed.ncbi.nlm.nih.gov/32244802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTC2,ENSG00000142025,Neither,34359134,Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profiles in Testes of Calves and Sexually Mature Wandong Bulls (Bos taurus).,2021,10.3390/ani11072006,https://pubmed.ncbi.nlm.nih.gov/34359134/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTC2,ENSG00000142025,Neither,29019938,"DMRTC2, PAX7, BRACHYURY/T and TERT Are Implicated in Male Germ Cell Development Following Curative Hormone Treatment for Cryptorchidism-Induced Infertility.",2017,10.3390/genes8100267,https://pubmed.ncbi.nlm.nih.gov/29019938/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTC2,ENSG00000142025,Neither,34458595,Identification of genetic modifiers of murine hepatic β-glucocerebrosidase activity.,2021,10.1016/j.bbrep.2021.101105,https://pubmed.ncbi.nlm.nih.gov/34458595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTC2,ENSG00000142025,Neither,27828963,Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo.,2016,10.1371/journal.pgen.1006429,https://pubmed.ncbi.nlm.nih.gov/27828963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTC2,ENSG00000142025,Neither,27150017,Generation and gene expression profiling of 48 transcription-factor-inducible mouse embryonic stem cell lines.,2016,10.1038/srep25667,https://pubmed.ncbi.nlm.nih.gov/27150017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTC2,ENSG00000142025,Neither,32126384,Identification of key genes associated with spermatogenesis arrest in fox hybrids using weighted gene co-expression network analysis.,2020,10.1016/j.theriogenology.2020.02.029,https://pubmed.ncbi.nlm.nih.gov/32126384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTC2,ENSG00000142025,Neither,25082981,Involvement of doublesex and mab-3-related transcription factors in human female germ cell development demonstrated by xenograft and interference RNA strategies.,2014,10.1093/molehr/gau058,https://pubmed.ncbi.nlm.nih.gov/25082981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTC2,ENSG00000142025,Neither,11863363,Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination.,2002,10.1006/geno.2002.6711,https://pubmed.ncbi.nlm.nih.gov/11863363/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,42323797,The potential role of dynein heavy chain genes in the pathophysiology of undescended testis.,2026,10.1007/s00383-026-06506-3,https://pubmed.ncbi.nlm.nih.gov/42323797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,41463044,Prenatal Low Testosterone Levels Induced by &lt;i&gt;DNAH8&lt;/i&gt; Dysfunction Leads to Urethral Fusion and Male Differentiation Abnormalities.,2025,10.3390/biomedicines13123032,https://pubmed.ncbi.nlm.nih.gov/41463044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,42480140,Gene-environment interaction in hypospadias: DEHP exposure aggravates DNAH8-related disruption of testicular steroidogenesis.,2026,10.1016/j.ecoenv.2026.120531,https://pubmed.ncbi.nlm.nih.gov/42480140/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,41809782,Homozygous &lt;i&gt;Myo7A&lt;/i&gt; mutation associations teratozoospermia and intracytoplasmic sperm injection failure in humans and mice.,2026,10.21037/tau-2025-474,https://pubmed.ncbi.nlm.nih.gov/41809782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,41437299,Reproductive physiological impacts of high ambient temperature on animals: the impaired testicular function and compromised sperm quality in C57BL/6 mice.,2025,10.1186/s40659-025-00662-x,https://pubmed.ncbi.nlm.nih.gov/41437299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,42585843,Targeted sequencing reveals a distinct genetic alteration landscape in oral multiple primary squamous cell carcinomas.,2026,10.1016/j.archoralbio.2026.106716,https://pubmed.ncbi.nlm.nih.gov/42585843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,36308074,A novel homozygous frameshift variant in DNAH8 causes multiple morphological abnormalities of the sperm flagella in a consanguineous Pakistani family.,2023,10.4103/aja202274,https://pubmed.ncbi.nlm.nih.gov/36308074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,39121979,The protective effect of glucose selenol on cadmium-induced testicular toxicity in male rat.,2024,10.1016/j.reprotox.2024.108679,https://pubmed.ncbi.nlm.nih.gov/39121979/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,37168556,Whole-exome sequencing study of hypospadias.,2023,10.1016/j.isci.2023.106663,https://pubmed.ncbi.nlm.nih.gov/37168556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,40810911,Biallelic loss-of-function variants of DNAH7 cause male infertility associated with asthenozoospermia in humans.,2025,10.1007/s00439-025-02766-6,https://pubmed.ncbi.nlm.nih.gov/40810911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,39267058,Whole exome sequencing analysis of 167 men with primary infertility.,2024,10.1186/s12920-024-02005-3,https://pubmed.ncbi.nlm.nih.gov/39267058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,32619401,Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility.,2020,10.1016/j.ajhg.2020.06.004,https://pubmed.ncbi.nlm.nih.gov/32619401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,38061432,Transcriptome and proteome analyses reveal the mechanisms involved in polystyrene nanoplastics disrupt spermatogenesis in mice.,2024,10.1016/j.envpol.2023.123086,https://pubmed.ncbi.nlm.nih.gov/38061432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,37998386,Ciliary Ultrastructure Assessed by Transmission Electron Microscopy in Adults with Bronchiectasis and Suspected Primary Ciliary Dyskinesia but Inconclusive Genotype.,2023,10.3390/cells12222651,https://pubmed.ncbi.nlm.nih.gov/37998386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,38563741,The association and underlying mechanism of the digit ratio (2D:4D) in hypospadias.,2024,10.4103/aja202377,https://pubmed.ncbi.nlm.nih.gov/38563741/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,33611675,A novel splicing variant in DNAH8 causes asthenozoospermia.,2021,10.1007/s10815-021-02116-1,https://pubmed.ncbi.nlm.nih.gov/33611675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,40371404,Primary ciliary dyskinesia: a case report of double DNAH11 mutant alleles.,2025,10.15386/mpr-2743,https://pubmed.ncbi.nlm.nih.gov/40371404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,37417617,"Association between chromosome 6p21 translocation and asthenozoospermia: A retrospective, observational study.",2023,10.1097/md.0000000000034318,https://pubmed.ncbi.nlm.nih.gov/37417617/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,36675580,A Novel Four Mitochondrial Respiration-Related Signature for Predicting Biochemical Recurrence of Prostate Cancer.,2023,10.3390/jcm12020654,https://pubmed.ncbi.nlm.nih.gov/36675580/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,31178125,"Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.",2019,10.1016/j.ajhg.2019.04.015,https://pubmed.ncbi.nlm.nih.gov/31178125/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,36618928,Cuproptosis-related lncRNA signatures predict prognosis and immune relevance of kidney renal papillary cell carcinoma.,2022,10.3389/fphar.2022.1103986,https://pubmed.ncbi.nlm.nih.gov/36618928/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,37004044,A lipid metabolism-based prognostic risk model for HBV-related hepatocellular carcinoma.,2023,10.1186/s12944-023-01780-9,https://pubmed.ncbi.nlm.nih.gov/37004044/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,36356568,Transcriptomic and proteomic characteristics of the di(2-ethylhexyl) phthalate-induced sperm dna damage mouse model.,2022,10.1177/09603271221139444,https://pubmed.ncbi.nlm.nih.gov/36356568/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,36851756,Automated SSHHPS Analysis Predicts a Potential Host Protein Target Common to Several Neuroinvasive (+)ssRNA Viruses.,2023,10.3390/v15020542,https://pubmed.ncbi.nlm.nih.gov/36851756/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,35680035,Admixture Mapping in African Americans Identifies New Risk Loci for HCV-Related Cirrhosis.,2023,10.1016/j.cgh.2022.05.020,https://pubmed.ncbi.nlm.nih.gov/35680035/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,36319832,A novel refined pyroptosis and inflammasome-related genes signature for predicting prognosis and immune microenvironment in pancreatic ductal adenocarcinoma.,2022,10.1038/s41598-022-22864-z,https://pubmed.ncbi.nlm.nih.gov/36319832/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,34696780,Identification of novel key genes associated with the metastasis of prostate cancer based on bioinformatics prediction and validation.,2021,10.1186/s12935-021-02258-3,https://pubmed.ncbi.nlm.nih.gov/34696780/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH8,ENSG00000124721,Neither,34529793,"Genetic diagnosis, sperm phenotype and ICSI outcome in case of severe asthenozoospermia with multiple morphological abnormalities of the flagellum.",2021,10.1093/humrep/deab200,https://pubmed.ncbi.nlm.nih.gov/34529793/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPEP3,ENSG00000141096,Neither,41861658,Exploring survival-associated transcriptomic subtypes in ovarian cancer using RNAseq from FFPE tissues in a clinical trial cohort.,2026,10.1016/j.tranon.2026.102740,https://pubmed.ncbi.nlm.nih.gov/41861658/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPEP3,ENSG00000141096,Neither,38654926,Proteomic biomarkers in seminal plasma as predictors of reproductive potential in azoospermic men.,2024,10.3389/fendo.2024.1327800,https://pubmed.ncbi.nlm.nih.gov/38654926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPEP3,ENSG00000141096,Neither,39367438,ADC: a deadly killer of platinum resistant ovarian cancer.,2024,10.1186/s13048-024-01523-z,https://pubmed.ncbi.nlm.nih.gov/39367438/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPEP3,ENSG00000141096,Neither,40823179,Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head.,2025,10.1515/med-2025-1145,https://pubmed.ncbi.nlm.nih.gov/40823179/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPEP3,ENSG00000141096,Neither,42465840,Integrated clinical and PBMC transcriptomic profiling identifies lipid metabolism-related candidate signatures associated with chronic brucellosis.,2026,10.3389/fcimb.2026.1725128,https://pubmed.ncbi.nlm.nih.gov/42465840/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPEP3,ENSG00000141096,Neither,37341056,Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer.,2023,10.1002/1878-0261.13474,https://pubmed.ncbi.nlm.nih.gov/37341056/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPEP3,ENSG00000141096,Neither,38218255,Comprehensive bioinformatics analysis of co-expressed genes of post-traumatic stress disorder and major depressive disorder.,2024,10.1016/j.jad.2024.01.098,https://pubmed.ncbi.nlm.nih.gov/38218255/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPEP3,ENSG00000141096,Neither,35338186,Effects of varicocele and microsurgical varicocelectomy on the metabolites in semen.,2022,10.1038/s41598-022-08954-y,https://pubmed.ncbi.nlm.nih.gov/35338186/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPEP3,ENSG00000141096,Neither,30097533,Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies.,2018,10.1074/mcp.ra118.000749,https://pubmed.ncbi.nlm.nih.gov/30097533/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPEP3,ENSG00000141096,Neither,41155123,Biological Interpretable Machine Learning Model for Predicting Pathological Grading in Clear Cell Renal Cell Carcinoma Based on CT Urography Peritumoral Radiomics Features.,2025,10.3390/bioengineering12101125,https://pubmed.ncbi.nlm.nih.gov/41155123/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPEP3,ENSG00000141096,Neither,32325220,Structure of human DPEP3 in complex with the SC-003 antibody Fab fragment reveals basis for lack of dipeptidase activity.,2020,10.1016/j.jsb.2020.107512,https://pubmed.ncbi.nlm.nih.gov/32325220/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPEP3,ENSG00000141096,Neither,31212048,The testis-specifically expressed Dpep3 is not essential for male fertility in mice.,2019,10.1016/j.gene.2019.06.015,https://pubmed.ncbi.nlm.nih.gov/31212048/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPEP3,ENSG00000141096,Neither,35864275,Lycium barbarum polysaccharide modulates gut microbiota to alleviate rheumatoid arthritis in a rat model.,2022,10.1038/s41538-022-00149-z,https://pubmed.ncbi.nlm.nih.gov/35864275/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPEP3,ENSG00000141096,Neither,32513564,Tamrintamab pamozirine (SC-003) in patients with platinum-resistant/refractory ovarian cancer: Findings of a phase 1 study.,2020,10.1016/j.ygyno.2020.05.038,https://pubmed.ncbi.nlm.nih.gov/32513564/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPEP3,ENSG00000141096,Neither,38482436,"A novel gene signature related to fatty acid metabolism predicts prognosis, immune landscape, and drug sensitivity in early-stage lung squamous cell carcinoma.",2024,10.21037/tcr-23-1640,https://pubmed.ncbi.nlm.nih.gov/38482436/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPEP3,ENSG00000141096,Neither,21724266,"Molecular characterization and expression of dipeptidase 3, a testis-specific membrane-bound dipeptidase: complex formation with TEX101, a germ-cell-specific antigen in the mouse testis.",2011,10.1016/j.jri.2011.04.010,https://pubmed.ncbi.nlm.nih.gov/21724266/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPEP3,ENSG00000141096,Neither,22140552,Identification of prognostic genes for recurrent risk prediction in triple negative breast cancer patients in Taiwan.,2011,10.1371/journal.pone.0028222,https://pubmed.ncbi.nlm.nih.gov/22140552/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,41862192,Embryonic stem cell factors DPPA2/4 amplify active H3K4me3-H2AK119ub chromatin domains in non-small cell lung cancer.,2026,10.1101/gad.353102.125,https://pubmed.ncbi.nlm.nih.gov/41862192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,42271492,From bone to beyond: osteoclasts dictate metastatic fate in lung adenocarcinoma via the OLFML3-DPPA2 stemness switch.,2026,10.1186/s13062-026-00851-y,https://pubmed.ncbi.nlm.nih.gov/42271492/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,42426342,Alterations in chromatin organization promote totipotent-like features in a DPPA2/DUX-dependent manner.,2026,10.1038/s44318-026-00853-6,https://pubmed.ncbi.nlm.nih.gov/42426342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,39949781,Identification and validation of a novel autoantibody biomarker panel for differential diagnosis of pancreatic ductal adenocarcinoma.,2025,10.3389/fimmu.2025.1494446,https://pubmed.ncbi.nlm.nih.gov/39949781/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,40244397,Dppa2 Promotes Early Embryo Development Through Regulating PDH Expression Pattern During Zygotic Genome Activation.,2025,10.3390/ijms26073436,https://pubmed.ncbi.nlm.nih.gov/40244397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,39969322,Refining of cancer-specific genes in microsatellite-unstable colon and endometrial cancers using modified partial least square discriminant analysis.,2024,10.1097/md.0000000000041134,https://pubmed.ncbi.nlm.nih.gov/39969322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,38474345,DPPA2/4 Promote the Pluripotency and Proliferation of Bovine Extended Pluripotent Stem Cells by Upregulating the PI3K/AKT/GSK3β/β-Catenin Signaling Pathway.,2024,10.3390/cells13050382,https://pubmed.ncbi.nlm.nih.gov/38474345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,41707844,"Characterization of the dppA1A2BCDF genes encoding a putative ABC transporter in Actinobacillus pleuropneumoniae: Role in glutathione utilization, oxidative stress tolerance and virulence.",2026,10.1016/j.micpath.2026.108390,https://pubmed.ncbi.nlm.nih.gov/41707844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,34767751,"DPPA2, DPPA4, and other DPPA factor epigenomic functions in cell fate and cancer.",2021,10.1016/j.stemcr.2021.10.008,https://pubmed.ncbi.nlm.nih.gov/34767751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,42116739,DUXA is not essential for parthenogenetic blastocyst formation but regulates cell proliferation in porcine embryos.,2026,10.1093/reprod/xaag060,https://pubmed.ncbi.nlm.nih.gov/42116739/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,41366101,Coordinated repression of totipotency-associated gene loci by histone methyltransferase EHMT2 via LINE1 regulatory elements.,2026,10.1038/s44319-025-00657-5,https://pubmed.ncbi.nlm.nih.gov/41366101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,41436486,The solute-binding proteins DppA1-5 of Pseudomonas aeruginosa have distinct substrate profiles.,2025,10.1038/s41598-025-27865-2,https://pubmed.ncbi.nlm.nih.gov/41436486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,40117000,DUBR non-coding RNA regulates gene expression by affecting AP-1 enhancer accessibility.,2025,10.1007/s10142-025-01582-5,https://pubmed.ncbi.nlm.nih.gov/40117000/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,34721660,"Transcription Factor CTCFL Promotes Cell Proliferation, Migration, and Invasion in Gastric Cancer via Activating DPPA2.",2021,10.1155/2021/9097931,https://pubmed.ncbi.nlm.nih.gov/34721660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,36553636,TWIST1 Plays Role in Expression of Stemness State Markers in ESCC.,2022,10.3390/genes13122369,https://pubmed.ncbi.nlm.nih.gov/36553636/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,39832417,Cracking the code: lncRNA-miRNA-mRNA integrated network analysis unveiling lncRNAs as promising non-invasive NAFLD biomarkers toward precision diagnosis.,2025,10.1016/j.compbiolchem.2024.108325,https://pubmed.ncbi.nlm.nih.gov/39832417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,34931676,Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival.,2021,10.1242/dev.200191,https://pubmed.ncbi.nlm.nih.gov/34931676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,39210793,Oleanolic acid improves the in vitro developmental competence of early porcine embryos by reducing oxidative stress and ameliorating mitochondrial function.,2025,10.5713/ab.24.0307,https://pubmed.ncbi.nlm.nih.gov/39210793/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,37488355,A genome-wide screen reveals new regulators of the 2-cell-like cell state.,2023,10.1038/s41594-023-01038-z,https://pubmed.ncbi.nlm.nih.gov/37488355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,34878123,DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development.,2021,10.1242/dev.200178,https://pubmed.ncbi.nlm.nih.gov/34878123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,38385532,Bivalent chromatin: a developmental balancing act tipped in cancer.,2024,10.1042/bst20230426,https://pubmed.ncbi.nlm.nih.gov/38385532/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,30446626,SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling.,2018,10.1242/dev.164160,https://pubmed.ncbi.nlm.nih.gov/30446626/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,32634384,A Single-Cell Transcriptomics CRISPR-Activation Screen Identifies Epigenetic Regulators of the Zygotic Genome Activation Program.,2020,10.1016/j.cels.2020.06.004,https://pubmed.ncbi.nlm.nih.gov/32634384/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,34573449,Modified Spirulina maxima Pectin Nanoparticles Improve the Developmental Competence of In Vitro Matured Porcine Oocytes.,2021,10.3390/ani11092483,https://pubmed.ncbi.nlm.nih.gov/34573449/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,19705800,Expression and serum immunoreactivity of developmentally restricted differentiation antigens in epithelial ovarian cancer.,2009,,https://pubmed.ncbi.nlm.nih.gov/19705800/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,18519755,ECSA/DPPA2 is an embryo-cancer antigen that is coexpressed with cancer-testis antigens in non-small cell lung cancer.,2008,10.1158/1078-0432.ccr-07-1322,https://pubmed.ncbi.nlm.nih.gov/18519755/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,25338022,High-throughput screening of dipeptide utilization mediated by the ABC transporter DppBCDF and its substrate-binding proteins DppA1-A5 in Pseudomonas aeruginosa.,2014,10.1371/journal.pone.0111311,https://pubmed.ncbi.nlm.nih.gov/25338022/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,19332562,The pluripotency-associated gene Dppa4 is dispensable for embryonic stem cell identity and germ cell development but essential for embryogenesis.,2009,10.1128/mcb.01970-08,https://pubmed.ncbi.nlm.nih.gov/19332562/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,23082221,Genome-wide association identifies multiple genomic regions associated with susceptibility to and control of ovine lentivirus.,2012,10.1371/journal.pone.0047829,https://pubmed.ncbi.nlm.nih.gov/23082221/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,22761758,Transcriptome analysis during human trophectoderm specification suggests new roles of metabolic and epigenetic genes.,2012,10.1371/journal.pone.0039306,https://pubmed.ncbi.nlm.nih.gov/22761758/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,19690622,Expression pattern of stemness-related genes in human endometrial and endometriotic tissues.,2009,10.2119/molmed.2009.00068,https://pubmed.ncbi.nlm.nih.gov/19690622/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,20201064,Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes.,2010,10.1002/stem.402,https://pubmed.ncbi.nlm.nih.gov/20201064/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA2,ENSG00000163530,Neither,15583978,"[Molecular cloning and characterization analysis of HPESCRG1, a novel gene expressed specifically in human embryonic stem cell].",2004,,https://pubmed.ncbi.nlm.nih.gov/15583978/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,42825230,Synergistic pairing of &lt;i&gt;Lactobacillus helveticus&lt;/i&gt; Stellar Lh-170 and &lt;i&gt;Lactiplantibacillus plantarum&lt;/i&gt; Stellar Lp-199 suppresses &lt;i&gt;Streptococcus mutans&lt;/i&gt; and disrupts cariogenic biofilms.,2026,10.1080/20002297.2026.2723648,https://pubmed.ncbi.nlm.nih.gov/42825230/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,42715318,JWST stellar occultation reveals unexpected changes in Chariklo's ring system.,2026,10.1126/sciadv.aeh4794,https://pubmed.ncbi.nlm.nih.gov/42715318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,39949781,Identification and validation of a novel autoantibody biomarker panel for differential diagnosis of pancreatic ductal adenocarcinoma.,2025,10.3389/fimmu.2025.1494446,https://pubmed.ncbi.nlm.nih.gov/39949781/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,41858777,Ascorbic acid enhances &lt;i&gt;in vitro&lt;/i&gt; primordial germ cell-like cell differentiation from mouse ESCs.,2026,10.3389/fcell.2026.1755998,https://pubmed.ncbi.nlm.nih.gov/41858777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,42543904,Executive Function and Epigenetic Markers in Youth Exposed to Family and Community Violence in Childhood.,2026,10.1002/dev.70183,https://pubmed.ncbi.nlm.nih.gov/42543904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,42649690,An Agent-Based Model of the Stellar Mass Distribution.,2026,10.3390/e28080895,https://pubmed.ncbi.nlm.nih.gov/42649690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,42758821,Star formation powers optical line emission from the CGM.,2026,10.1126/sciadv.aec3939,https://pubmed.ncbi.nlm.nih.gov/42758821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,41318009,Development of canine testicular organoid for assessing the effects of environmental exposure.,2026,10.1016/j.reprotox.2025.109117,https://pubmed.ncbi.nlm.nih.gov/41318009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,42311011,"Gestational Age, Maternal Age, and Culture Dynamics Shape the Pluripotency Marker Profile of Primary Amniocytes: Insights for Stem Cell Biology and Regenerative Applications.",2026,10.2174/011574888x442884260424071917,https://pubmed.ncbi.nlm.nih.gov/42311011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,42724195,Super-Critical Accretion onto Stellar Mass Black Holes and Neutron Stars: A Short Review.,2026,10.1007/s11214-026-01318-2,https://pubmed.ncbi.nlm.nih.gov/42724195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,42350005,Studying Early Life Live-Attenuated influenza virus immune Responses (STELLAR): study protocol for an exploratory observational study of the nasal mucosal and systemic immune response in healthy children given an intranasal live-attenuated influenza vaccine.,2026,10.1136/bmjopen-2025-114107,https://pubmed.ncbi.nlm.nih.gov/42350005/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,40222672,The embryonic DPPA3 gene stimulates the expression of pregnancy-related genes in bovine endometrial cells.,2025,10.3168/jds.2024-25872,https://pubmed.ncbi.nlm.nih.gov/40222672/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,42406813,Generating solutions for charged compact configurations in f(R) gravity.,2026,10.1371/journal.pone.0349625,https://pubmed.ncbi.nlm.nih.gov/42406813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,41249242,An intelligent brain tumor detection model using lightweight hybrid twin attentive pyramid convolutional network.,2025,10.1038/s41598-025-23813-2,https://pubmed.ncbi.nlm.nih.gov/41249242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,41512968,Development of Highly Multiplex Targeted Proteomics Assays in Biofluids Using a Nominal Mass Ion Trap Mass Spectrometer.,2026,10.1016/j.mcpro.2026.101506,https://pubmed.ncbi.nlm.nih.gov/41512968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,42020398,The fragmentation properties of massive star-forming regions in 30Dor-10 at 2000 au resolution.,2026,10.1038/s41467-026-71515-8,https://pubmed.ncbi.nlm.nih.gov/42020398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,39225212,Intimal Macrovascular Pericytes: Their Role in Vascular Biology and Atherogenesis.,2025,10.2174/0109298673295675240826070754,https://pubmed.ncbi.nlm.nih.gov/39225212/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,41311380,Engineered plant extracellular vesicles: Emerging nanoplatforms for combinational cancer immunotherapy.,2025,10.1016/j.apsb.2025.08.020,https://pubmed.ncbi.nlm.nih.gov/41311380/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,41359380,Nanoscale dynamics of enhancer-promoter interactions during exit from pluripotency.,2025,10.1093/nar/gkaf1255,https://pubmed.ncbi.nlm.nih.gov/41359380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,40710358,Gene Expression Analysis of HPRT-Deficient Cells Maintained with Physiological Levels of Folic Acid.,2025,10.3390/cells14141105,https://pubmed.ncbi.nlm.nih.gov/40710358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,41802306,Immunotherapy for microsatellite-stable colorectal cancer: overcoming resistance and exploring novel therapeutic strategies.,2026,10.3393/ac.2025.01354.0193,https://pubmed.ncbi.nlm.nih.gov/41802306/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,42187894,"Total Neoadjuvant Therapy, Organ Preservation and Beyond: A State-of-the-Art Systematic Review and Critical Appraisal of Locally Advanced Rectal Cancer Management.",2026,10.3390/diseases14050182,https://pubmed.ncbi.nlm.nih.gov/42187894/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,41694372,Myeloid-derived suppressor cells and regulatory T cells in colorectal cancer: a synergistic immunosuppressive axis and emerging therapeutic opportunities.,2026,10.3389/fimmu.2026.1757513,https://pubmed.ncbi.nlm.nih.gov/41694372/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,42604092,"Total neoadjuvant therapy for rectal cancer: where are we now, where do we go?",2026,10.1016/j.ctro.2026.101254,https://pubmed.ncbi.nlm.nih.gov/42604092/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,42744133,Biomarker-guided treatment selection in metastatic colorectal cancer: A critical review of established and emerging therapies.,2026,10.1016/j.critrevonc.2026.105597,https://pubmed.ncbi.nlm.nih.gov/42744133/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,40248950,STELLAR-305: phase II/III study of zanzalintinib plus pembrolizumab versus pembrolizumab alone in patients with HNSCC.,2025,10.1080/14796694.2025.2485015,https://pubmed.ncbi.nlm.nih.gov/40248950/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,41883872,"Molecular complete response to the RIN protocol (regorafenib, ipilimumab, and nivolumab) in a patient with advanced recurrent metastatic mismatch repair proficient/microsatellite stable (pMMR/MSS) rectal cancer.",2026,10.1177/17588359261432049,https://pubmed.ncbi.nlm.nih.gov/41883872/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,42803451,STELLAR-311: a randomized phase II/III study of zanzalintinib versus everolimus in advanced neuroendocrine tumors.,2026,10.1080/14796694.2026.2733790,https://pubmed.ncbi.nlm.nih.gov/42803451/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,40008409,STELLAR-304: a phase III study of zanzalintinib (XL092) plus nivolumab in advanced non-clear cell renal cell carcinoma.,2025,10.1080/14796694.2025.2458395,https://pubmed.ncbi.nlm.nih.gov/40008409/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,41519113,STELLAR-303: Breaking the immunotherapy wall in MSS colorectal cancer.,2026,10.1016/j.medj.2025.100957,https://pubmed.ncbi.nlm.nih.gov/41519113/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,42789827,Erratum: Five-Year Outcomes of Short-Term Radiotherapy Plus Chemotherapy Versus Long-Term Chemoradiotherapy for Locally Advanced Rectal Cancer: Updated Results of the STELLAR Trial.,2026,10.1200/jco-26-02343,https://pubmed.ncbi.nlm.nih.gov/42789827/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,41130252,"Zanzalintinib plus atezolizumab versus regorafenib in refractory colorectal cancer (STELLAR-303): a randomised, open-label, phase 3 trial.",2025,10.1016/s0140-6736(25)02025-2,https://pubmed.ncbi.nlm.nih.gov/41130252/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,42199292,An International Phase 4 Study of Lenvatinib and Sorafenib in Real-World Patients with Unresectable Hepatocellular Carcinoma: Final Analysis.,2026,10.1159/000552115,https://pubmed.ncbi.nlm.nih.gov/42199292/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,40266436,"Tumor Treating Fields (TTFields) Therapy in Unresectable Pleural Mesothelioma: Overview of Efficacy, Safety, and Future Outlook.",2025,10.1007/s11864-025-01320-w,https://pubmed.ncbi.nlm.nih.gov/40266436/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,39041200,STELLAR-303: randomized phase III study of zanzalintinib + atezolizumab in previously treated metastatic colorectal cancer.,2024,10.1080/14796694.2024.2352276,https://pubmed.ncbi.nlm.nih.gov/39041200/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,42208730,Sotatercept Safety and Efficacy in Intermediate- to Low-Risk Pulmonary Arterial Hypertension: A Pooled Analysis of PULSAR and STELLAR.,2026,10.1016/j.chest.2026.04.056,https://pubmed.ncbi.nlm.nih.gov/42208730/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,41596417,"Sotatercept in Pulmonary Arterial Hypertension: Molecular Mechanisms, Clinical Evidence, and Emerging Role in Reverse Remodelling.",2026,10.3390/ijms27020767,https://pubmed.ncbi.nlm.nih.gov/41596417/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,14990856,"Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma.",2004,10.1634/stemcells.22-2-169,https://pubmed.ncbi.nlm.nih.gov/14990856/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,14654002,Stella is a maternal effect gene required for normal early development in mice.,2003,10.1016/j.cub.2003.11.026,https://pubmed.ncbi.nlm.nih.gov/14654002/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA3,ENSG00000187569,Neither,14684992,Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours.,2003,10.1159/000074346,https://pubmed.ncbi.nlm.nih.gov/14684992/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,42311011,"Gestational Age, Maternal Age, and Culture Dynamics Shape the Pluripotency Marker Profile of Primary Amniocytes: Insights for Stem Cell Biology and Regenerative Applications.",2026,10.2174/011574888x442884260424071917,https://pubmed.ncbi.nlm.nih.gov/42311011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,38227647,Ubiquitin E3 Ligase FBXO9 Regulates Pluripotency by Targeting DPPA5 for Ubiquitylation and Degradation.,2024,10.1093/stmcls/sxae004,https://pubmed.ncbi.nlm.nih.gov/38227647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,41436486,The solute-binding proteins DppA1-5 of Pseudomonas aeruginosa have distinct substrate profiles.,2025,10.1038/s41598-025-27865-2,https://pubmed.ncbi.nlm.nih.gov/41436486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,33691965,ENLARGED STARCH GRAIN1 affects amyloplast development and starch biosynthesis in rice endosperm.,2021,10.1016/j.plantsci.2021.110831,https://pubmed.ncbi.nlm.nih.gov/33691965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,37743309,[Biomarkers associated with severity classification of asthma identified by comprehensive bioinformatics analysis].,2023,10.3760/cma.j.cn112150-20230301-00165,https://pubmed.ncbi.nlm.nih.gov/37743309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,32916865,Human Mesenchymal Stromal Cells Unveil an Unexpected Differentiation Potential toward the Dopaminergic Neuronal Lineage.,2020,10.3390/ijms21186589,https://pubmed.ncbi.nlm.nih.gov/32916865/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,29927686,Loci-specific differences in blood DNA methylation in HBV-negative populations at risk for hepatocellular carcinoma development.,2018,10.1080/15592294.2018.1481706,https://pubmed.ncbi.nlm.nih.gov/29927686/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,31210434,Pluripotency Potential of Embryonic Stem Cell-Like Cells Derived from Mouse Testis.,2019,10.22074/cellj.2019.6068,https://pubmed.ncbi.nlm.nih.gov/31210434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,26661329,DPPA5 Supports Pluripotency and Reprogramming by Regulating NANOG Turnover.,2016,10.1002/stem.2252,https://pubmed.ncbi.nlm.nih.gov/26661329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,16504174,Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5).,2006,10.1186/1471-213x-6-11,https://pubmed.ncbi.nlm.nih.gov/16504174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,26575221,Brain-specific epigenetic markers of schizophrenia.,2015,10.1038/tp.2015.177,https://pubmed.ncbi.nlm.nih.gov/26575221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,24882002,Dppa5 improves hematopoietic stem cell activity by reducing endoplasmic reticulum stress.,2014,10.1016/j.celrep.2014.04.056,https://pubmed.ncbi.nlm.nih.gov/24882002/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,32424450,Conversion between porcine naïve-like and primed ESCs and specific pluripotency marker identification.,2020,10.1007/s11626-020-00448-3,https://pubmed.ncbi.nlm.nih.gov/32424450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,27173828,Derivation of Porcine Embryonic Stem-Like Cells from In Vitro-Produced Blastocyst-Stage Embryos.,2016,10.1038/srep25838,https://pubmed.ncbi.nlm.nih.gov/27173828/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,25515008,Establishment of a primed pluripotent epiblast stem cell in FGF4-based conditions.,2014,10.1038/srep07477,https://pubmed.ncbi.nlm.nih.gov/25515008/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,29299196,Extract of mouse embryonic stem cells induces the expression of pluripotency genes in human adipose tissue-derived stem cells.,2017,10.22038/ijbms.2017.9464,https://pubmed.ncbi.nlm.nih.gov/29299196/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,24618709,Low pH reprograms somatic murine cells into pluripotent stem cells: a novel technique with therapeutic implications.,2014,10.4161/cbt.28414,https://pubmed.ncbi.nlm.nih.gov/24618709/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,30015890,Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape.,2018,10.3892/or.2018.6551,https://pubmed.ncbi.nlm.nih.gov/30015890/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,28746394,Effects of oxidative and thermal stresses on stress granule formation in human induced pluripotent stem cells.,2017,10.1371/journal.pone.0182059,https://pubmed.ncbi.nlm.nih.gov/28746394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,17967063,Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters.,2007,10.1371/journal.pgen.0030181,https://pubmed.ncbi.nlm.nih.gov/17967063/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,25338022,High-throughput screening of dipeptide utilization mediated by the ABC transporter DppBCDF and its substrate-binding proteins DppA1-A5 in Pseudomonas aeruginosa.,2014,10.1371/journal.pone.0111311,https://pubmed.ncbi.nlm.nih.gov/25338022/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,22511923,A model of cancer stem cells derived from mouse induced pluripotent stem cells.,2012,10.1371/journal.pone.0033544,https://pubmed.ncbi.nlm.nih.gov/22511923/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,22532788,Data mining in networks of differentially expressed genes during sow pregnancy.,2012,10.7150/ijbs.4071,https://pubmed.ncbi.nlm.nih.gov/22532788/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA5,ENSG00000203909,Neither,24465482,Efficient reprogramming of naïve-like induced pluripotent stem cells from porcine adipose-derived stem cells with a feeder-independent and serum-free system.,2014,10.1371/journal.pone.0085089,https://pubmed.ncbi.nlm.nih.gov/24465482/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,41944163,Transgenic mouse models for investigating human DUX4 expression during development and its roles in FSHD pathophysiology.,2026,10.1242/dmm.052637,https://pubmed.ncbi.nlm.nih.gov/41944163/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,41510809,"Identification of KHDC1L, a DUX4-regulated protein, as a novel plasma biomarker in facioscapulohumeral muscular dystrophy.",2026,10.1093/hmg/ddaf183,https://pubmed.ncbi.nlm.nih.gov/41510809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,42304059,Identification of compounds that repress DUX4 expression in facioscapulohumeral muscular dystrophy.,2026,10.1038/s41598-026-57734-5,https://pubmed.ncbi.nlm.nih.gov/42304059/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,42198843,Lipid nanoparticle delivery of antisense gapmers attenuates pathology in a mouse model of facioscapulohumeral muscular dystrophy.,2026,10.1016/j.ymthe.2026.05.010,https://pubmed.ncbi.nlm.nih.gov/42198843/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,41994867,Development of a DUX4-targeting antibody oligonucleotide conjugate as a therapy for FSHD.,2026,10.1093/nar/gkag301,https://pubmed.ncbi.nlm.nih.gov/41994867/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,41540238,A new integrated genetic and transcriptomic approach for investigating DUX4 and DUX4C.,2026,10.1038/s10038-025-01450-x,https://pubmed.ncbi.nlm.nih.gov/41540238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,40855454,"DUX4 at 25: how it emerged from ""junk DNA"" to become the cause of facioscapulohumeral muscular dystrophy.",2025,10.1186/s13395-025-00388-0,https://pubmed.ncbi.nlm.nih.gov/40855454/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,41575738,Modeling of Capicua Family Fusion Oncoprotein-Driven Cancers Reveals Gene-Specific Functionality.,2026,10.1158/1541-7786.mcr-25-0624,https://pubmed.ncbi.nlm.nih.gov/41575738/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,41513943,Chemical inhibition of SUMOylation activates the FSHD locus.,2026,10.1038/s41598-025-33624-0,https://pubmed.ncbi.nlm.nih.gov/41513943/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,40940582,DUX4-rearranged B-ALL: deciphering a biological and clinical conundrum.,2025,10.1038/s41375-025-02758-5,https://pubmed.ncbi.nlm.nih.gov/40940582/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,42249080,The emergence and diversification of the DUX gene family across placental mammals.,2026,10.1038/s42003-026-10442-2,https://pubmed.ncbi.nlm.nih.gov/42249080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,42302177,Targeting CIC::DUX4 sarcoma with Minnelide in a dual recombinase-initiated genetically engineered mouse model.,2026,10.1172/jci202218,https://pubmed.ncbi.nlm.nih.gov/42302177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,40333962,DUX4 activates common and context-specific intergenic transcripts and isoforms.,2025,10.1126/sciadv.adt5356,https://pubmed.ncbi.nlm.nih.gov/40333962/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,41986233,KLF18 is a necessary component of the DUX4-initiated transcriptional network and a candidate locus for phenotypic diversity.,2026,10.1101/gad.353253.125,https://pubmed.ncbi.nlm.nih.gov/41986233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,42181289,Elevated labile iron contributes to membrane repair deficits in facioscapulohumeral muscular dystrophy.,2026,10.1016/j.isci.2026.115781,https://pubmed.ncbi.nlm.nih.gov/42181289/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,42912981,SMCHD1 loss rewires MYOD1 enhancer nexuses and chromatin accessibility landscapes in muscle cells.,2026,10.1126/sciadv.aeh7499,https://pubmed.ncbi.nlm.nih.gov/42912981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,41329166,"DUX4-induced HSATII RNA accumulation drives protein aggregation, impacting RNA processing pathways.",2026,10.1083/jcb.202501129,https://pubmed.ncbi.nlm.nih.gov/41329166/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,42256952,&lt;i&gt;CIC-DUX4&lt;/i&gt; Rearranged Gastric Sarcoma Confirmed by Next-Generation Sequencing: A Case Report and Review of Literature.,2026,10.1002/ccr3.72797,https://pubmed.ncbi.nlm.nih.gov/42256952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,41536811,&lt;i&gt;DUX4&lt;/i&gt; reduction and muscle function improvement by subcutaneous delivery of gapmer antisense oligonucleotides.,2026,10.1016/j.omtn.2025.102791,https://pubmed.ncbi.nlm.nih.gov/41536811/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,42068352,A primary subcutaneous sarcoma with ATXN1::DUX4 fusion: the first report in soft tissue and further evidence for a CIC/ATXN1 pathway-altered sarcoma family.,2026,10.1007/s00428-026-04563-6,https://pubmed.ncbi.nlm.nih.gov/42068352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,42066431,Spatiotemporal DUX4 toxicity in FSHD: from epigenetic derepression to biomarker-driven targeted therapies.,2026,10.1016/j.nmd.2026.106420,https://pubmed.ncbi.nlm.nih.gov/42066431/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,42679210,EARLY RESPONSE AND GENETICS DEFINE RELAPSE RISK AFTER FRONTLINE BLINATUMOMAB IN CHILDHOOD B-ALL: A COHORT STUDY.,2026,10.1182/bloodadvances.2026021026,https://pubmed.ncbi.nlm.nih.gov/42679210/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,42630082,Biomarkers in facioscapulohumeral muscular dystrophy.,2026,10.1097/wco.0000000000001513,https://pubmed.ncbi.nlm.nih.gov/42630082/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,40673060,A systemically deliverable lipid-conjugated siRNA targeting DUX4 as an facioscapulohumeral muscular dystrophy therapeutic.,2025,10.1016/j.omtm.2025.101513,https://pubmed.ncbi.nlm.nih.gov/40673060/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,40128305,Immunologic correlates in a CIC::DUX4 fusion-positive sarcoma responsive to dual immune checkpoint blockade.,2025,10.1038/s41698-025-00878-w,https://pubmed.ncbi.nlm.nih.gov/40128305/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,40734767,Rapid Identification of &lt;i&gt;DUX4::IGH&lt;/i&gt; Fusion in Acute Lymphoblastic Leukemia.,2025,10.1002/jha2.70099,https://pubmed.ncbi.nlm.nih.gov/40734767/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,42301101,Nanoparticle therapeutics in FSHD: current research and future perspectives.,2026,10.1039/d6nr01374k,https://pubmed.ncbi.nlm.nih.gov/42301101/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,41299516,Modeling CIC::DUX4 sarcoma reveals oncogene-mediated MHCI-dependent immune evasion.,2025,10.1186/s12943-025-02485-6,https://pubmed.ncbi.nlm.nih.gov/41299516/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,40591405,Iron supplementation alleviates pathologies in a mouse model of facioscapulohumeral muscular dystrophy.,2025,10.1172/jci181881,https://pubmed.ncbi.nlm.nih.gov/40591405/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,40634301,Estrogen rescues muscle regeneration impaired by DUX4 in a humanized xenograft mouse model.,2025,10.1038/s41419-025-07827-2,https://pubmed.ncbi.nlm.nih.gov/40634301/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,40580827,The recent clinical trial of losmapimod for the treatment of facioscapulohumeral muscular dystrophy.,2025,10.1016/j.nmd.2025.105422,https://pubmed.ncbi.nlm.nih.gov/40580827/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,38829686,DUX4 is a common driver of immune evasion and immunotherapy failure in metastatic cancers.,2024,10.7554/elife.89017,https://pubmed.ncbi.nlm.nih.gov/38829686/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,21060811,Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene.,2010,10.1371/journal.pgen.1001181,https://pubmed.ncbi.nlm.nih.gov/21060811/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUX4,ENSG00000260596,Neither,17984056,"DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1.",2007,10.1073/pnas.0708659104,https://pubmed.ncbi.nlm.nih.gov/17984056/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYDC1,ENSG00000170788,Neither,39849482,IQUB mutation induces radial spoke 1 deficiency causing asthenozoospermia with normal sperm morphology in humans and mice.,2025,10.1186/s12964-025-02043-z,https://pubmed.ncbi.nlm.nih.gov/39849482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYDC1,ENSG00000170788,Neither,19545932,Interaction of SH3P13 and DYDC1 protein: a germ cell component that regulates acrosome biogenesis during spermiogenesis.,2009,10.1016/j.ejcb.2009.05.001,https://pubmed.ncbi.nlm.nih.gov/19545932/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYDC1,ENSG00000170788,Neither,30221015,Towards integrated oncogenic marker recognition through mutual information-based statistically significant feature extraction: an association rule mining based study on cancer expression and methylation profiles.,2017,10.1007/s40484-017-0119-0,https://pubmed.ncbi.nlm.nih.gov/30221015/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYDC1,ENSG00000170788,Neither,18197198,Myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7: corroboration and narrowing of the critical region on 10q22.3.,2008,10.1038/sj.ejhg.5201980,https://pubmed.ncbi.nlm.nih.gov/18197198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBLN1,ENSG00000223601,Neither,42695496,Endogenous Bornavirus-Like Nucleoprotein 1 Regulates Cellular Processes and DNA Double-Strand Breaks in U-87 MG Glioblastoma Cells.,2026,10.1002/cnr2.70680,https://pubmed.ncbi.nlm.nih.gov/42695496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBLN1,ENSG00000223601,Neither,27023521,Knock-Down of Endogenous Bornavirus-Like Nucleoprotein 1 Inhibits Cell Growth and Induces Apoptosis in Human Oligodendroglia Cells.,2016,10.3390/ijms17040435,https://pubmed.ncbi.nlm.nih.gov/27023521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBLN1,ENSG00000223601,Neither,27739501,"The bornavirus-derived human protein EBLN1 promotes efficient cell cycle transit, microtubule organisation and genome stability.",2016,10.1038/srep35548,https://pubmed.ncbi.nlm.nih.gov/27739501/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBLN1,ENSG00000223601,Neither,26480920,Genome-wide association studies suggest sex-specific loci associated with abdominal and visceral fat.,2016,10.1038/ijo.2015.217,https://pubmed.ncbi.nlm.nih.gov/26480920/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBLN1,ENSG00000223601,Neither,20054395,Endogenous non-retroviral RNA virus elements in mammalian genomes.,2010,10.1038/nature08695,https://pubmed.ncbi.nlm.nih.gov/20054395/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB3,ENSG00000172421,Neither,30275530,Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci.,2018,10.1038/s41588-018-0223-8,https://pubmed.ncbi.nlm.nih.gov/30275530/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB3,ENSG00000172421,Neither,34617051,Whole genome sequencing identifies loci specifically associated with thoracic aortic wall defects and abdominal aortic aneurysms in patients with European ancestry.,2020,10.1016/j.jvssci.2020.09.001,https://pubmed.ncbi.nlm.nih.gov/34617051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB8,ENSG00000215529,Neither,34159570,Novel Mutation and Deletion in SUN5 Cause Male Infertility with Acephalic Spermatozoa Syndrome.,2022,10.1007/s43032-021-00665-5,https://pubmed.ncbi.nlm.nih.gov/34159570/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB8,ENSG00000215529,Neither,32776659,Evaluation of relationship between DNA methyltransferase 3 β gene and the risk of hip osteoarthritis: A case-control study based on a Han Chinese population.,2020,10.1111/1756-185x.13943,https://pubmed.ncbi.nlm.nih.gov/32776659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB8,ENSG00000215529,Neither,25563226,Differential transcriptome profile of peripheral white cells to identify biomarkers involved in oxaliplatin induced neuropathy.,2014,10.3390/jpm4020282,https://pubmed.ncbi.nlm.nih.gov/25563226/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENTHD1,ENSG00000176177,Neither,26870154,Whole-Exome Sequencing Identifies Novel Somatic Mutations in Chinese Breast Cancer Patients.,2015,10.4172/1747-0862.1000183,https://pubmed.ncbi.nlm.nih.gov/26870154/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,25289806,Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret.,2015,10.1016/j.mce.2014.09.029,https://pubmed.ncbi.nlm.nih.gov/25289806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,19801999,Localization of epididymal protease inhibitor in adult rat and its transcription profile in testis during postnatal development.,2009,10.1038/aja.2009.66,https://pubmed.ncbi.nlm.nih.gov/19801999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,22332118,The development of an inducible androgen receptor knockout model in mouse to study the postmeiotic effects of androgens on germ cell development.,2011,10.4161/spmg.1.4.18740,https://pubmed.ncbi.nlm.nih.gov/22332118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,23160479,Temporal role of Sertoli cell androgen receptor expression in spermatogenic development.,2013,10.1210/me.2012-1219,https://pubmed.ncbi.nlm.nih.gov/23160479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,19587329,Organotypic cultures of prepubertal mouse testes: a method to study androgen action in sertoli cells while preserving their natural environment.,2009,10.1095/biolreprod.109.078360,https://pubmed.ncbi.nlm.nih.gov/19587329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,24440575,Ligand-dependent stabilization of androgen receptor in a novel mouse ST38c Sertoli cell line.,2014,10.1016/j.mce.2014.01.008,https://pubmed.ncbi.nlm.nih.gov/24440575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,23070980,Epididymal protease inhibitor (EPPIN) is differentially expressed in the male rat reproductive tract and immunolocalized in maturing spermatozoa.,2012,10.1002/mrd.22119,https://pubmed.ncbi.nlm.nih.gov/23070980/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,21427128,Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome.,2011,10.1093/hmg/ddr109,https://pubmed.ncbi.nlm.nih.gov/21427128/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,19574395,Sertoli cell androgen receptor DNA binding domain is essential for the completion of spermatogenesis.,2009,10.1210/en.2009-0416,https://pubmed.ncbi.nlm.nih.gov/19574395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,21461566,Distribution of Eppin in mouse and human testis.,2011,10.3892/mmr.2010.403,https://pubmed.ncbi.nlm.nih.gov/21461566/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,19136570,Effects of FSH on testicular mRNA transcript levels in the hypogonadal mouse.,2009,10.1677/jme-08-0107,https://pubmed.ncbi.nlm.nih.gov/19136570/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,21936831,Functional studies of eppin.,2011,10.1042/bst0391447,https://pubmed.ncbi.nlm.nih.gov/21936831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,21441428,Epididymal protein targets: a brief history of the development of epididymal protease inhibitor as a contraceptive.,2011,10.2164/jandrol.110.012781,https://pubmed.ncbi.nlm.nih.gov/21441428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,17928628,Alterations in gene expression in the caput epididymides of nonobstructive azoospermic men.,2008,10.1095/biolreprod.107.062760,https://pubmed.ncbi.nlm.nih.gov/17928628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,20505168,Alterations in the human blood-epididymis barrier in obstructive azoospermia and the development of novel epididymal cell lines from infertile men.,2010,10.1095/biolreprod.110.084459,https://pubmed.ncbi.nlm.nih.gov/20505168/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,15590901,Association of eppin with semenogelin on human spermatozoa.,2005,10.1095/biolreprod.104.036483,https://pubmed.ncbi.nlm.nih.gov/15590901/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,18945989,Inhibition of human sperm motility by contraceptive anti-eppin antibodies from infertile male monkeys: effect on cyclic adenosine monophosphate.,2009,10.1095/biolreprod.108.072942,https://pubmed.ncbi.nlm.nih.gov/18945989/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,21908656,Induction of specific immune response and suppression of fertility by B-cell-epitope-based mimovirus vaccine.,2011,10.1530/rep-11-0161,https://pubmed.ncbi.nlm.nih.gov/21908656/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN-WFDC6,ENSG00000249139,Neither,11404006,Cloning and sequencing of human Eppin: a novel family of protease inhibitors expressed in the epididymis and testis.,2001,10.1016/s0378-1119(01)00462-0,https://pubmed.ncbi.nlm.nih.gov/11404006/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERICH6,ENSG00000163645,Neither,36175606,Necroptosis-related lncRNA signature predicts prognosis and immune response for cervical squamous cell carcinoma and endocervical adenocarcinomas.,2022,10.1038/s41598-022-20858-5,https://pubmed.ncbi.nlm.nih.gov/36175606/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERICH6,ENSG00000163645,Neither,35075611,Constructing a Novel Signature Based on Immune-Related lncRNA to Improve Prognosis Prediction of Cervical Squamous Cell Carcinoma Patients.,2022,10.1007/s43032-022-00851-z,https://pubmed.ncbi.nlm.nih.gov/35075611/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERICH6B,ENSG00000165837,Neither,40136285,Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy.,2025,10.1167/iovs.66.3.55,https://pubmed.ncbi.nlm.nih.gov/40136285/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,39269631,Endogenous retroviral ERVH48-1 promotes human urine cell reprogramming.,2024,10.1186/s13619-024-00200-2,https://pubmed.ncbi.nlm.nih.gov/39269631/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,40394751,Associations of placental lncRNA expression with maternal pre-pregnancy BMI and infant birthweight in two birth cohorts.,2025,10.1017/s204017442500011x,https://pubmed.ncbi.nlm.nih.gov/40394751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,39146934,A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development.,2024,10.1016/j.stem.2024.07.006,https://pubmed.ncbi.nlm.nih.gov/39146934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,38408442,Human Endogenous Retroviruses in Breast Cancer: Altered Expression Pattern Implicates Divergent Roles in Carcinogenesis.,2024,10.1159/000538021,https://pubmed.ncbi.nlm.nih.gov/38408442/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,36980789,RETRACTED: LncRNA ERVH48-1 Contributes to the Drug Resistance of Prostate Cancer and Proliferation through Sponging of miR-4784 to the Activation of the Wnt/β-Catenin Pathway.,2023,10.3390/cancers15061902,https://pubmed.ncbi.nlm.nih.gov/36980789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,38002309,"Controlling Trophoblast Cell Fusion in the Human Placenta-Transcriptional Regulation of Suppressyn, an Endogenous Inhibitor of Syncytin-1.",2023,10.3390/biom13111627,https://pubmed.ncbi.nlm.nih.gov/38002309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,40143747,The lncRNAs PART1 and ADAMTS9-AS2 act in an antithetic manner on AR signaling and induction of cellular senescence in prostate cancer cells.,2025,10.1097/js9.0000000000002334,https://pubmed.ncbi.nlm.nih.gov/40143747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,40941751,Deep Learning-Based DNA Methylation Detection in Cervical Cancer Using the One-Hot Character Representation Technique.,2025,10.3390/diagnostics15172263,https://pubmed.ncbi.nlm.nih.gov/40941751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,36386793,Immunotherapy response and microenvironment provide biomarkers of immunotherapy options for patients with lung adenocarcinoma.,2022,10.3389/fgene.2022.1047435,https://pubmed.ncbi.nlm.nih.gov/36386793/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,34638599,"Could the Human Endogenous Retrovirus-Derived Syncytialization Inhibitor, Suppressyn, Limit Heterotypic Cell Fusion Events in the Decidua?",2021,10.3390/ijms221910259,https://pubmed.ncbi.nlm.nih.gov/34638599/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,37028593,Genome-Wide Analysis of Hypoxia-Inducible Factor Binding Reveals Targets Implicated in Impaired Human Placental Syncytiotrophoblast Formation under Low Oxygen.,2023,10.1016/j.ajpath.2023.03.006,https://pubmed.ncbi.nlm.nih.gov/37028593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,33504453,Syncytins expressed in human placental trophoblast.,2021,10.1016/j.placenta.2021.01.006,https://pubmed.ncbi.nlm.nih.gov/33504453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,32411397,Placental lncRNA expression associated with placental cadmium concentrations and birth weight.,2020,10.1093/eep/dvaa003,https://pubmed.ncbi.nlm.nih.gov/32411397/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,31576252,Identification of lncRNAs associated with lung squamous cell carcinoma prognosis in the competitive endogenous RNA network.,2019,10.7717/peerj.7727,https://pubmed.ncbi.nlm.nih.gov/31576252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,30755833,Comprehensive analysis of lncRNA-associated competing endogenous RNA network in tongue squamous cell carcinoma.,2019,10.7717/peerj.6397,https://pubmed.ncbi.nlm.nih.gov/30755833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,32468063,Long non‑coding RNA‑based risk scoring system predicts prognosis of alcohol‑related hepatocellular carcinoma.,2020,10.3892/mmr.2020.11179,https://pubmed.ncbi.nlm.nih.gov/32468063/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,18158183,Cellular localization of placenta-specific human endogenous retrovirus (HERV) transcripts and their possible implication in pregnancy-induced hypertension.,2008,10.1016/j.placenta.2007.11.009,https://pubmed.ncbi.nlm.nih.gov/18158183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,17186567,"C21ORF105, A chromosome 21-encoded mRNA, is not a discriminative marker gene for prediction of Down syndrome in maternal plasma.",2007,10.1002/pd.1637,https://pubmed.ncbi.nlm.nih.gov/17186567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,18223136,Measurement of allelic-expression ratios in trisomy 21 placentas by quencher extension of heterozygous samples identified by partially denaturing HPLC.,2008,10.1373/clinchem.2007.095539,https://pubmed.ncbi.nlm.nih.gov/18223136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVH48-1,ENSG00000233056,Neither,23492904,A novel human endogenous retroviral protein inhibits cell-cell fusion.,2013,10.1038/srep01462,https://pubmed.ncbi.nlm.nih.gov/23492904/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETDB,ENSG00000224107,Neither,30986271,ETDB-Caltech: A blockchain-based distributed public database for electron tomography.,2019,10.1371/journal.pone.0215531,https://pubmed.ncbi.nlm.nih.gov/30986271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETDB,ENSG00000224107,Neither,24548632,Dual blockade of endothelin action exacerbates up-regulated VEGF angiogenic signaling in the heart of lipopolysaccharide-induced endotoxemic rat model.,2014,10.1016/j.lfs.2014.02.008,https://pubmed.ncbi.nlm.nih.gov/24548632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETDB,ENSG00000224107,Neither,23180768,Strategies for annotation and curation of translational databases: the eTUMOUR project.,2012,10.1093/database/bas035,https://pubmed.ncbi.nlm.nih.gov/23180768/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETDB,ENSG00000224107,Neither,8561977,Early biopsy versus empiric treatment with delayed biopsy of non-responders in suspected HIV-associated cerebral toxoplasmosis: a decision analysis.,1995,10.1097/00002030-199511000-00005,https://pubmed.ncbi.nlm.nih.gov/8561977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,42260403,EVX2 methylation assay enables risk assessment of cervical cancer in high-risk HPV-infected individuals.,2026,10.1186/s12885-026-16256-z,https://pubmed.ncbi.nlm.nih.gov/42260403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,38907278,Amplifications of EVX2 and HOXD9-HOXD13 on 2q31 in mature cystic teratomas of the ovary identified by array comparative genomic hybridization may explain teratoma characteristics in chondrogenesis and osteogenesis.,2024,10.1186/s13048-024-01458-5,https://pubmed.ncbi.nlm.nih.gov/38907278/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,38017520,Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells.,2023,10.1186/s13064-023-00176-w,https://pubmed.ncbi.nlm.nih.gov/38017520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,38181310,Genome-Wide Association Studies of 3 Distinct Recovery Phenotypes in Mild Ischemic Stroke.,2024,10.1212/wnl.0000000000208011,https://pubmed.ncbi.nlm.nih.gov/38181310/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,34276786,Expression Profiling and Functional Analysis of Candidate Col10a1 Regulators Identified by the TRAP Program.,2021,10.3389/fgene.2021.683939,https://pubmed.ncbi.nlm.nih.gov/34276786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,33994355,Role of vertebrate GAGA associated factor (vGAF) in early development of zebrafish.,2021,10.1016/j.cdev.2021.203682,https://pubmed.ncbi.nlm.nih.gov/33994355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,26896392,Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2-independent mechanism.,2016,10.1186/s13064-016-0059-9,https://pubmed.ncbi.nlm.nih.gov/26896392/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,33245713,Identification of novel prognostic markers of survival time in high-risk neuroblastoma using gene expression profiles.,2020,10.18632/oncotarget.27808,https://pubmed.ncbi.nlm.nih.gov/33245713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,27553035,Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons.,2016,10.1186/s13064-016-0070-1,https://pubmed.ncbi.nlm.nih.gov/27553035/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,26940624,HoxD expression in the fin-fold compartment of basal gnathostomes and implications for paired appendage evolution.,2016,10.1038/srep22720,https://pubmed.ncbi.nlm.nih.gov/26940624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,32821544,Genome-wide identification of CpG island methylator phenotype related gene signature as a novel prognostic biomarker of gastric cancer.,2020,10.7717/peerj.9624,https://pubmed.ncbi.nlm.nih.gov/32821544/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,17245451,Evx2-Hoxd13 intergenic region restricts enhancer association to Hoxd13 promoter.,2007,10.1371/journal.pone.0000175,https://pubmed.ncbi.nlm.nih.gov/17245451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,21098566,A functionally conserved boundary element from the mouse HoxD locus requires GAGA factor in Drosophila.,2010,10.1242/dev.058701,https://pubmed.ncbi.nlm.nih.gov/21098566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,26883901,A genome-wide association study identifies a genomic region for the polycerate phenotype in sheep (Ovis aries).,2016,10.1038/srep21111,https://pubmed.ncbi.nlm.nih.gov/26883901/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,20648051,Mesomelic dysplasia Kantaputra type is associated with duplications of the HOXD locus on chromosome 2q.,2010,10.1038/ejhg.2010.116,https://pubmed.ncbi.nlm.nih.gov/20648051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,16322559,HoxD cluster scanning deletions identify multiple defects leading to paralysis in the mouse mutant Ironside.,2005,10.1101/gad.351105,https://pubmed.ncbi.nlm.nih.gov/16322559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,15509224,Conserved expression domains for genes upstream and within the HoxA and HoxD clusters suggests a long-range enhancer existed before cluster duplication.,2004,10.1111/j.1525-142x.2004.04050.x,https://pubmed.ncbi.nlm.nih.gov/15509224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,11778160,A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly.,2002,10.1086/338921,https://pubmed.ncbi.nlm.nih.gov/11778160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,12732147,A global control region defines a chromosomal regulatory landscape containing the HoxD cluster.,2003,10.1016/s0092-8674(03)00310-6,https://pubmed.ncbi.nlm.nih.gov/12732147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,9879709,Expression of two even-skipped genes eve1 and evx2 during zebrafish fin morphogenesis and their regulation by retinoic acid.,1998,,https://pubmed.ncbi.nlm.nih.gov/9879709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EVX2,ENSG00000174279,Neither,37243888,Transcriptome sequencing identifies novel EVX fusions involved in transcriptional activation of HOX family genes in pediatric immature T-cell acute lymphoblastic leukemia: two cases reports and a literature review.,2023,10.1007/s12185-023-03619-6,https://pubmed.ncbi.nlm.nih.gov/37243888/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM170B,ENSG00000172538,Neither,38250762,"Involvement of FAM170B-AS1, hsa-miR-1202, and hsa-miR-146a-5p in breast cancer.",2024,10.3233/cbm-230396,https://pubmed.ncbi.nlm.nih.gov/38250762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM170B,ENSG00000172538,Neither,32588889,"Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in mice†.",2020,10.1093/biolre/ioaa082,https://pubmed.ncbi.nlm.nih.gov/32588889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM170B,ENSG00000172538,Neither,26179146,"FAM170B, a novel acrosomal protein involved in fertilization in mice.",2015,10.1002/mrd.22523,https://pubmed.ncbi.nlm.nih.gov/26179146/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM170B,ENSG00000172538,Neither,30046591,Analysis of the Cancer Genome Atlas Data Reveals Novel Putative ncRNAs Targets in Hepatocellular Carcinoma.,2018,10.1155/2018/2864120,https://pubmed.ncbi.nlm.nih.gov/30046591/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM170B,ENSG00000172538,Neither,30402224,Identification of 26 novel loci that confer susceptibility to early-onset coronary artery disease in a Japanese population.,2018,10.3892/br.2018.1152,https://pubmed.ncbi.nlm.nih.gov/30402224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM186A,ENSG00000185958,Neither,36289533,DUSP5 and PHLDA1 mutations in mature cystic teratomas of the ovary identified on whole-exome sequencing may explain teratoma characteristics.,2022,10.1186/s40246-022-00424-w,https://pubmed.ncbi.nlm.nih.gov/36289533/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM186A,ENSG00000185958,Neither,31277598,Novel significant stage-specific differentially expressed genes in hepatocellular carcinoma.,2019,10.1186/s12885-019-5838-3,https://pubmed.ncbi.nlm.nih.gov/31277598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM186A,ENSG00000185958,Neither,29963304,Six novel susceptibility loci for coronary artery disease and cerebral infarction identified by longitudinal exome-wide association studies in a Japanese population.,2018,10.3892/br.2018.1109,https://pubmed.ncbi.nlm.nih.gov/29963304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM186A,ENSG00000185958,Neither,26553438,Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer.,2015,10.1038/srep16286,https://pubmed.ncbi.nlm.nih.gov/26553438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM186B,ENSG00000135436,Neither,26932277,Pathway Analysis using Gene-expression Profiles of HPV-positive and HPV-negative Oropharyngeal Cancer Patients in a Hispanic Population: Methodological Procedures.,2016,,https://pubmed.ncbi.nlm.nih.gov/26932277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM186B,ENSG00000135436,Neither,26489029,Whole exome sequencing identifies causative mutations in the majority of consanguineous or familial cases with childhood-onset increased renal echogenicity.,2016,10.1038/ki.2015.317,https://pubmed.ncbi.nlm.nih.gov/26489029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM217A,ENSG00000145975,Neither,37493860,Pan-primate studies of age and sex.,2023,10.1007/s11357-023-00878-3,https://pubmed.ncbi.nlm.nih.gov/37493860/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM236B,ENSG00000268994,Neither,39391249,Molecular genetic characterization of myeloid neoplasms with idic(X)(q13) and i(X)(q10).,2024,10.3389/fonc.2024.1428984,https://pubmed.ncbi.nlm.nih.gov/39391249/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM47B,ENSG00000189132,Neither,36017582,Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia.,2022,10.1111/andr.13269,https://pubmed.ncbi.nlm.nih.gov/36017582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM47C,ENSG00000198173,Neither,41420248,"Sitravatinib plus tislelizumab in locally recurrent or metastatic triple-negative breast cancer: a multi-cohort, single-arm, phase II clinical trial (SPARK Trial).",2025,10.1186/s12943-025-02505-5,https://pubmed.ncbi.nlm.nih.gov/41420248/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM47C,ENSG00000198173,Neither,36017582,Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia.,2022,10.1111/andr.13269,https://pubmed.ncbi.nlm.nih.gov/36017582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9A,ENSG00000183304,Neither,37594251,Scrutinizing the human TEX genes in the context of human male infertility.,2024,10.1111/andr.13511,https://pubmed.ncbi.nlm.nih.gov/37594251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9A,ENSG00000183304,Neither,39299262,Identification and Characterization of Key Genes Associated with Amelogenesis.,2025,10.1055/s-0044-1787958,https://pubmed.ncbi.nlm.nih.gov/39299262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9A,ENSG00000183304,Neither,29789566,Transcriptome analysis of the adult human Klinefelter testis and cellularity-matched controls reveals disturbed differentiation of Sertoli- and Leydig cells.,2018,10.1038/s41419-018-0671-1,https://pubmed.ncbi.nlm.nih.gov/29789566/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9A,ENSG00000183304,Neither,35022708,Ancestry- and sex-specific effects underlying inguinal hernia susceptibility identified in a multiethnic genome-wide association study meta-analysis.,2022,10.1093/hmg/ddac003,https://pubmed.ncbi.nlm.nih.gov/35022708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9A,ENSG00000183304,Neither,30675680,Unbalanced X;9 translocation in an infertile male with de novo duplication Xp22.31p22.33.,2019,10.1007/s10815-019-01405-0,https://pubmed.ncbi.nlm.nih.gov/30675680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9A,ENSG00000183304,Neither,29441621,Novel interstitial deletion in Xp22.3 in a typical X-linked recessive family with Kallmann syndrome.,2018,10.1111/and.12961,https://pubmed.ncbi.nlm.nih.gov/29441621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9A,ENSG00000183304,Neither,21685710,Disease-dependent differently methylated regions (D-DMRs) of DNA are enriched on the X chromosome in uterine leiomyoma.,2011,10.1262/jrd.11-035a,https://pubmed.ncbi.nlm.nih.gov/21685710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9A,ENSG00000183304,Neither,12213195,A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region.,2002,10.1006/geno.2002.6834,https://pubmed.ncbi.nlm.nih.gov/12213195/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCD2OS,ENSG00000163705,Neither,35798552,Fancd2os Reduces Testosterone Production by Inhibiting Steroidogenic Enzymes and Promoting Cellular Apoptosis in Murine Testicular Leydig Cells.,2022,10.3803/enm.2022.1431,https://pubmed.ncbi.nlm.nih.gov/35798552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCD2OS,ENSG00000163705,Neither,38431614,"An EWAS of dementia biomarkers and their associations with age, African ancestry, and PTSD.",2024,10.1186/s13148-024-01649-3,https://pubmed.ncbi.nlm.nih.gov/38431614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,42597893,Mutation Severity of &lt;i&gt;FBXO43&lt;/i&gt; Determines Spermatogenic Outcome and Informs Precision ART Strategies.,2026,10.1155/humu/7905936,https://pubmed.ncbi.nlm.nih.gov/42597893/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,41828362,Genetic Mutations and Non-Genomic Dysregulation in Human Preimplantation Embryo Arrest.,2026,10.3390/ijms27052135,https://pubmed.ncbi.nlm.nih.gov/41828362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,41828918,Transcriptome Analysis of Different Stages in the Early Ovarian Development of the Greater Amberjack (&lt;i&gt;Seriola dumerili&lt;/i&gt;).,2026,10.3390/ani16050709,https://pubmed.ncbi.nlm.nih.gov/41828918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,37560338,High Expression of F-Box Protein 43 Is Associated With Poor Prognosis and Adjuvant Chemotherapy Resistance in Colorectal Cancer.,2023,10.14740/wjon1642,https://pubmed.ncbi.nlm.nih.gov/37560338/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,39747666,A phosphate-binding pocket in cyclin B3 is essential for XErp1/Emi2 degradation in meiosis I.,2025,10.1038/s44319-024-00347-8,https://pubmed.ncbi.nlm.nih.gov/39747666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,40875626,Machine learning-based identification of diagnostic and prognostic mitotic cell cycle genes in hepatocellular carcinoma.,2025,10.1371/journal.pone.0331118,https://pubmed.ncbi.nlm.nih.gov/40875626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,38604312,FBXO43 promotes cell cycle progression in cancer cells through stabilizing SKP2.,2024,10.1016/j.canlet.2024.216848,https://pubmed.ncbi.nlm.nih.gov/38604312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,37250703,"Clinical significance of FBXO43 in hepatocellular carcinoma and its impact on tumor cell proliferation, migration and invasion.",2023,10.7717/peerj.15373,https://pubmed.ncbi.nlm.nih.gov/37250703/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,35363516,Emi2 enables centriole amplification during multiciliated cell differentiation.,2022,10.1126/sciadv.abm7538,https://pubmed.ncbi.nlm.nih.gov/35363516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,41898836,Transcriptional Modulation of Infertility-Associated Genes Following &lt;i&gt;Chlamydia trachomatis&lt;/i&gt; Infection in Human Fallopian Tube Mesenchymal Cells: In Silico Study.,2026,10.3390/genes17030302,https://pubmed.ncbi.nlm.nih.gov/41898836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,36765911,"F-Box Protein 43, Stabilized by N6-Methyladenosine Methylation, Enhances Hepatocellular Carcinoma Cell Growth and Invasion via Promoting p53 Degradation in a Ubiquitin Conjugating Enzyme E2 C-Dependent Manner.",2023,10.3390/cancers15030957,https://pubmed.ncbi.nlm.nih.gov/36765911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,36710413,Association between F-box-only protein 43 overexpression and hepatocellular carcinoma pathogenesis and prognosis.,2023,10.1002/cam4.5660,https://pubmed.ncbi.nlm.nih.gov/36710413/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,36937431,FBXO43 increases CCND1 stability to promote hepatocellular carcinoma cell proliferation and migration.,2023,10.3389/fonc.2023.1138348,https://pubmed.ncbi.nlm.nih.gov/36937431/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,40309238,The C-terminal domain of Emi2 conjugated to cell-penetrating peptide activates mouse oocyte.,2025,10.3389/fcell.2025.1578020,https://pubmed.ncbi.nlm.nih.gov/40309238/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,32253818,EMI2 expression as a poor prognostic factor in patients with breast cancer.,2020,10.1002/kjm2.12208,https://pubmed.ncbi.nlm.nih.gov/32253818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,38998084,The Whole Genome DNA Methylation Signatures of Hindlimb Muscles in Chinese Alligators during Hibernation and Active Periods.,2024,10.3390/ani14131972,https://pubmed.ncbi.nlm.nih.gov/38998084/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,34933678,YY1 activates EMI2 and promotes the progression of cholangiocarcinoma through the PI3K/Akt signaling axis.,2021,10.1186/s12935-021-02328-6,https://pubmed.ncbi.nlm.nih.gov/34933678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,34645483,Downregulation of the FBXO43 gene inhibits tumor growth in human breast cancer by limiting its interaction with PCNA.,2021,10.1186/s12967-021-03100-0,https://pubmed.ncbi.nlm.nih.gov/34645483/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,34595750,A homozygous loss-of-function mutation in FBXO43 causes human non-obstructive azoospermia.,2022,10.1111/cge.14069,https://pubmed.ncbi.nlm.nih.gov/34595750/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,38812312,A Predictive Model Based on the FBXO Family Reveals the Significance of Cyclin F in Hepatocellular Carcinoma.,2024,10.31083/j.fbl2905202,https://pubmed.ncbi.nlm.nih.gov/38812312/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,34052850,FBXO43 variants in patients with female infertility characterized by early embryonic arrest.,2021,10.1093/humrep/deab131,https://pubmed.ncbi.nlm.nih.gov/34052850/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,37186772,Determination of the minimal important difference for inspiratory muscle strength in people with severe and very severe COPD.,2023,10.1177/02692155231174124,https://pubmed.ncbi.nlm.nih.gov/37186772/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,36834647,"The Role of Mitotic Slippage in Creating a ""Female Pregnancy-like System"" in a Single Polyploid Giant Cancer Cell.",2023,10.3390/ijms24043237,https://pubmed.ncbi.nlm.nih.gov/36834647/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO43,ENSG00000156509,Neither,22302686,A zinc-dependent mechanism regulates meiotic progression in mammalian oocytes.,2012,10.1095/biolreprod.111.097253,https://pubmed.ncbi.nlm.nih.gov/22302686/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO47,ENSG00000204952,Neither,42216099,Neddylation is indispensable for early meiotic progression in spermatocytes via destabilizing HORMAD1 by SCF ubiquitin E3 ligase during synapsis.,2026,10.1186/s13578-026-01597-w,https://pubmed.ncbi.nlm.nih.gov/42216099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO47,ENSG00000204952,Neither,40161258,Protective effects of corn silk and &lt;i&gt;asparagus Officinalis&lt;/i&gt; against formaldehyde-induced reproductive toxicity in male rats via CDK2/Spem1/Fbxo47 and Tet1 pathways.,2025,10.1093/toxres/tfaf039,https://pubmed.ncbi.nlm.nih.gov/40161258/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO47,ENSG00000204952,Neither,39244596,FBXO47 regulates centromere pairing as key component of centromeric SCF E3 ligase in mouse spermatocytes.,2024,10.1038/s42003-024-06782-6,https://pubmed.ncbi.nlm.nih.gov/39244596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO47,ENSG00000204952,Neither,35310947,FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis.,2022,10.1016/j.isci.2022.104008,https://pubmed.ncbi.nlm.nih.gov/35310947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO47,ENSG00000204952,Neither,32057909,In vitro effects of androgen on testicular development by the AR-foxl3-rec8/fbxo47 axis in orange-spotted grouper (Epinephelus coioides).,2020,10.1016/j.ygcen.2020.113435,https://pubmed.ncbi.nlm.nih.gov/32057909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO47,ENSG00000204952,Neither,31724724,FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis.,2019,10.1093/nar/gkz992,https://pubmed.ncbi.nlm.nih.gov/31724724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO47,ENSG00000204952,Neither,35489071,SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination.,2022,10.1093/nar/gkac304,https://pubmed.ncbi.nlm.nih.gov/35489071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO47,ENSG00000204952,Neither,35217607,PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2.,2022,10.1073/pnas.2114401119,https://pubmed.ncbi.nlm.nih.gov/35217607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO47,ENSG00000204952,Neither,37304650,GABPB1-AS1 acts as a tumor suppressor and inhibits non-small cell lung cancer progression by targeting miRNA-566/F-box protein 47.,2021,10.32604/or.2022.025262,https://pubmed.ncbi.nlm.nih.gov/37304650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO47,ENSG00000204952,Neither,32409601,"foxl3, a sexual switch in germ cells, initiates two independent molecular pathways for commitment to oogenesis in medaka.",2020,10.1073/pnas.1918556117,https://pubmed.ncbi.nlm.nih.gov/32409601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO47,ENSG00000204952,Neither,37744913,Genetic assessment of the effect of red yeast (&lt;i&gt;Sporidiobolus pararoseus&lt;/i&gt;) as a feed additive on mycotoxin toxicity in laying hens.,2023,10.3389/fmicb.2023.1254569,https://pubmed.ncbi.nlm.nih.gov/37744913/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO47,ENSG00000204952,Neither,32592804,"A 3'-tRNA-derived fragment enhances cell proliferation, migration and invasion in gastric cancer by targeting FBXO47.",2020,10.1016/j.abb.2020.108467,https://pubmed.ncbi.nlm.nih.gov/32592804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO47,ENSG00000204952,Neither,30392839,Novel components of germline sex determination acting downstream of foxl3 in medaka.,2019,10.1016/j.ydbio.2018.10.019,https://pubmed.ncbi.nlm.nih.gov/30392839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO47,ENSG00000204952,Neither,29661569,Analysis of GWAS-linked variants in multiple system atrophy.,2018,10.1016/j.neurobiolaging.2018.03.018,https://pubmed.ncbi.nlm.nih.gov/29661569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO47,ENSG00000204952,Neither,27629089,A genome-wide association study in multiple system atrophy.,2016,10.1212/wnl.0000000000003221,https://pubmed.ncbi.nlm.nih.gov/27629089/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO47,ENSG00000204952,Neither,15723337,"Molecular cloning and characterization of FBXO47, a novel gene containing an F-box domain, located in the 17q12 band deleted in papillary renal cell carcinoma.",2005,10.1002/gcc.20170,https://pubmed.ncbi.nlm.nih.gov/15723337/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO47,ENSG00000204952,Neither,17914060,Caenorhabditis elegans prom-1 is required for meiotic prophase progression and homologous chromosome pairing.,2007,10.1091/mbc.e07-03-0243,https://pubmed.ncbi.nlm.nih.gov/17914060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,42805119,FGF4 sustained-release nano-liposomes attenuate heat stroke-induced MODS by suppressing ZBP1-mediated programmed necrosis.,2026,10.1016/j.intimp.2026.117414,https://pubmed.ncbi.nlm.nih.gov/42805119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,41290710,FGF4-FGFR1 signaling promotes podocyte survival and glomerular function to ameliorate diabetic kidney disease in male mice.,2025,10.1038/s41467-025-65978-4,https://pubmed.ncbi.nlm.nih.gov/41290710/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,41521789,Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids.,2026,10.1242/dev.205459,https://pubmed.ncbi.nlm.nih.gov/41521789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,42010459,Effects of FGF4/HIF-1α axis-mediated neuronal glycolysis on neuropathic pain.,2026,10.1186/s10194-026-02362-7,https://pubmed.ncbi.nlm.nih.gov/42010459/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,41724991,FGF4 activates FGFR1 - PI3K/AKT signaling to enhance Clec10a-mediated intracellular myelin debris processing and promote spinal cord repair.,2026,10.1186/s12974-026-03743-0,https://pubmed.ncbi.nlm.nih.gov/41724991/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,41882225,FGF4 initiates X-chromosome inactivation via activating YY1 and prompting loss of pluripotency factors.,2026,10.1038/s44318-026-00722-2,https://pubmed.ncbi.nlm.nih.gov/41882225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,42573050,A Mechanistic Review of Environmental Stressor to Decode Their Effect on Congenital Malformations: A Developmental Toxicity.,2026,10.1002/jbt.71067,https://pubmed.ncbi.nlm.nih.gov/42573050/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,41347806,FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;.,2026,10.3892/ijmm.2025.5710,https://pubmed.ncbi.nlm.nih.gov/41347806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,40677395,Cardiac-targeted FGF4 encapsulated nanoliposomes improve acute myocardial injury induced by ischemia-reperfusion and adriamycin in in vitro and in vivo models.,2025,10.1016/j.mtbio.2025.101984,https://pubmed.ncbi.nlm.nih.gov/40677395/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,41039618,FGF4 drives tumor progression in triple-negative breast cancer via IL6/STAT3-mediated macrophage M2 polarization and immune suppression.,2025,10.1186/s13008-025-00164-y,https://pubmed.ncbi.nlm.nih.gov/41039618/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,41665009,Distinct roles for SETα and SETβ in early cell fate decisions.,2026,10.1093/nar/gkag105,https://pubmed.ncbi.nlm.nih.gov/41665009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,40849639,CAF-derived exosomes drive the FGF4/SHH feedback loop by encapsulating GREM1 in non-small cell lung cancer.,2025,10.1186/s10020-025-01340-0,https://pubmed.ncbi.nlm.nih.gov/40849639/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,42191879,Fibroblast growth factor receptor inhibition for succinate dehydrogenase-deficient gastrointestinal stromal tumors: a phase 2 trial.,2026,10.1038/s41591-026-04376-9,https://pubmed.ncbi.nlm.nih.gov/42191879/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,41492091,De novo H3.3K27M-altered diffuse midline glioma in human brainstem organoids to dissect GD2 CAR T cell function.,2026,10.1038/s43018-025-01084-0,https://pubmed.ncbi.nlm.nih.gov/41492091/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,39095789,FGF4 ameliorates the liver inflammation by reducing M1 macrophage polarization in experimental autoimmune hepatitis.,2024,10.1186/s12967-024-05219-2,https://pubmed.ncbi.nlm.nih.gov/39095789/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,40446208,Donor embryonic stem cells displace host cells of 8-cell-stage chimeras to the extra-embryonic lineages by spatial crowding and FGF4 signalling.,2025,10.1242/dev.204518,https://pubmed.ncbi.nlm.nih.gov/40446208/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,39055102,"A Potential Role of fgf4, fgf24, and fgf17 in Pharyngeal Pouch Formation in Zebrafish.",2024,10.12717/dr.2024.28.2.55,https://pubmed.ncbi.nlm.nih.gov/39055102/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,42380747,Fgf evolution in vertebrates: insights from cyclostomes.,2026,10.1186/s12864-026-13104-z,https://pubmed.ncbi.nlm.nih.gov/42380747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,40259859,Biallelic FGF4 Variants Linked to Thoracic Dystrophy and Respiratory Insufficiency.,2025,10.1111/cge.14758,https://pubmed.ncbi.nlm.nih.gov/40259859/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,40978202,Ccar1 prevents β-catenin nuclear translocation to sustain ground-state pluripotency in mouse ESCs under R2i.,2025,10.1016/j.bbrep.2025.102246,https://pubmed.ncbi.nlm.nih.gov/40978202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,42512413,Genomic Characterization of Urothelial Carcinoma and Sarcomatoid Carcinoma of the Upper Urinary Tract.,2026,10.3390/cancers18142352,https://pubmed.ncbi.nlm.nih.gov/42512413/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,41555058,A novel oncogenic nonsense mutation of SMARCA4 and genetic characteristic analysis of SMARCA4 (BRG1)-deficient undifferentiated tumor of the bladder.,2026,10.1007/s00428-026-04402-8,https://pubmed.ncbi.nlm.nih.gov/41555058/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,42681846,Synthetic Heparan Sulfate-like Oligosaccharides as Tools to Decipher Growth Factor Recognition.,2026,10.1021/acs.jmedchem.6c00760,https://pubmed.ncbi.nlm.nih.gov/42681846/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,42164467,A novel prognostic biomarker combining &lt;i&gt;TP53&lt;/i&gt; loss-of-function and amplification of different combinations of nine genes in lung squamous cell carcinoma treated with chemotherapy.,2026,10.3892/ol.2026.15644,https://pubmed.ncbi.nlm.nih.gov/42164467/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,39168622,Fibroblast Growth Factors in Cardiovascular Disease.,2024,10.5551/jat.rv22025,https://pubmed.ncbi.nlm.nih.gov/39168622/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,42252959,Comprehensive Genomic Characterization Between Urothelial Carcinoma Subtypes/Divergent Differentiation (S/DD) and Pure Urothelial Carcinoma Using a Large-Scale Japanese Genomic Panel Dataset.,2026,10.1111/iju.70538,https://pubmed.ncbi.nlm.nih.gov/42252959/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,42758366,An Accessible Approach to Molecular and Biomarker Testing for Risk Stratification in Oral Cavity Squamous Cell Carcinoma.,2026,10.1007/s12105-026-01968-2,https://pubmed.ncbi.nlm.nih.gov/42758366/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,38572102,FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis.,2024,10.1016/j.apsb.2023.12.012,https://pubmed.ncbi.nlm.nih.gov/38572102/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,40306455,Embryonic developmental toxicity to estuarine fish: Single and co-exposure to EHMC and its phototransformation products in Mugilogobius chulae.,2025,10.1016/j.envres.2025.121733,https://pubmed.ncbi.nlm.nih.gov/40306455/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FGF4,ENSG00000075388,Neither,39349833,FGF4 and ascorbic acid enhance the maturation of induced cardiomyocytes by activating JAK2-STAT3 signaling.,2024,10.1038/s12276-024-01321-z,https://pubmed.ncbi.nlm.nih.gov/39349833/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FNDC7,ENSG00000143107,Neither,36626432,Expression and prognosis analyses of the fibronectin type-III domain-containing (FNDC) protein family in human cancers: A Review.,2022,10.1097/md.0000000000031854,https://pubmed.ncbi.nlm.nih.gov/36626432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FNDC7,ENSG00000143107,Neither,37545519,Exome sequencing to explore the possibility of predicting genetic susceptibility to the joint occurrence of polycystic ovary syndrome and Hashimoto's thyroiditis.,2023,10.3389/fimmu.2023.1193293,https://pubmed.ncbi.nlm.nih.gov/37545519/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FNDC7,ENSG00000143107,Neither,30139389,Association of internal smoking dose with blood DNA methylation in three racial/ethnic populations.,2018,10.1186/s13148-018-0543-7,https://pubmed.ncbi.nlm.nih.gov/30139389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,42820249,Anterior segment dysgenesis with bilateral acorea and microphthalmia associated with compound heterozygous FOXE3 pathogenic variants: outcomes after optical iridectomy.,2026,10.1080/13816810.2026.2738870,https://pubmed.ncbi.nlm.nih.gov/42820249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,40833324,Insights Into the FOXE3 Transcriptional Network and Disease Mechanisms From the Investigation of a Regulatory Variant Driving Complex Microphthalmia.,2025,10.1167/iovs.66.11.47,https://pubmed.ncbi.nlm.nih.gov/40833324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,41680104,Concurrent mutations in &lt;i&gt;DNAH5&lt;/i&gt; and &lt;i&gt;FOXE3&lt;/i&gt; genes: a unique occurrence in infancy.,2026,10.5115/acb.25.317,https://pubmed.ncbi.nlm.nih.gov/41680104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,42000104,Meis1 and Meis2 are jointly required for advanced stages of mouse lens morphogenesis.,2026,10.1016/j.ydbio.2026.04.006,https://pubmed.ncbi.nlm.nih.gov/42000104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,40326030,Genetic Studies on Multiple Consanguineous Families Segregating Diverse Phenotypes of Microphthalmia Identified Novel and Recurrent Mutations.,2026,10.2174/0109298673365255250418092319,https://pubmed.ncbi.nlm.nih.gov/40326030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,40850233,Generation of the induced pluripotent stem cell line IOCVi002-A from a patient with the FOXE3-related sclerocornea-aphakia malformation.,2025,10.1016/j.scr.2025.103816,https://pubmed.ncbi.nlm.nih.gov/40850233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,39512904,Genetic analysis of medaka fish illuminates conserved and divergent roles of Pax6 in vertebrate eye development.,2024,10.3389/fcell.2024.1448773,https://pubmed.ncbi.nlm.nih.gov/39512904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,38095908,JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens Fiber Maturation in Murine Lens Development.,2023,10.1167/iovs.64.15.15,https://pubmed.ncbi.nlm.nih.gov/38095908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,36192130,"Real-world clinical and molecular management of 50 prospective patients with microphthalmia, anophthalmia and/or ocular coloboma.",2023,10.1136/bjo-2022-321991,https://pubmed.ncbi.nlm.nih.gov/36192130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,38683565,miR-26 Deficiency Causes Alterations in Lens Transcriptome and Results in Adult-Onset Cataract.,2024,10.1167/iovs.65.4.42,https://pubmed.ncbi.nlm.nih.gov/38683565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,40427049,Genetic Analysis of &lt;i&gt;CYP1B1&lt;/i&gt; and Other Anterior Segment Dysgenesis-Associated Genes in Latvian Cohort of Primary Congenital Glaucoma.,2025,10.3390/biomedicines13051222,https://pubmed.ncbi.nlm.nih.gov/40427049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,36359912,Generation of Lens Progenitor Cells and Lentoid Bodies from Pluripotent Stem Cells: Novel Tools for Human Lens Development and Ocular Disease Etiology.,2022,10.3390/cells11213516,https://pubmed.ncbi.nlm.nih.gov/36359912/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,37203095,Distinct gene expression profiles underlie morphological and etiological differences in pediatric cataracts.,2023,10.4103/ijo.ijo_3269_22,https://pubmed.ncbi.nlm.nih.gov/37203095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,39965745,"Crosstalk between signaling pathways (Rho/ROCK, TGF-β and Wnt/β-Catenin Pathways/ PI3K-AKT-mTOR) in Cataract: A Mechanistic Exploration and therapeutic strategy.",2025,10.1016/j.gene.2025.149338,https://pubmed.ncbi.nlm.nih.gov/39965745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,37628625,Combined Single Gene Testing and Genome Sequencing as an Effective Diagnostic Approach for Anophthalmia and Microphthalmia Patients.,2023,10.3390/genes14081573,https://pubmed.ncbi.nlm.nih.gov/37628625/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,39652009,Potential Involvements of Anterior Segment Dysgenesis-Associated Genes in Primary Congenital Glaucoma.,2025,10.1080/08820538.2024.2435944,https://pubmed.ncbi.nlm.nih.gov/39652009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,34046667,Comprehensive phenotypic and functional analysis of dominant and recessive FOXE3 alleles in ocular developmental disorders.,2021,10.1093/hmg/ddab142,https://pubmed.ncbi.nlm.nih.gov/34046667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,29713869,A zebrafish model of foxe3 deficiency demonstrates lens and eye defects with dysregulation of key genes involved in cataract formation in humans.,2018,10.1007/s00439-018-1884-1,https://pubmed.ncbi.nlm.nih.gov/29713869/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,30479708,Association of FOXE3-p.Ala170Ala and PITX3-p.Ile95Ile Polymorphisms with Congenital Cataract and Microphthalmia.,2018,10.4103/jovr.jovr_193_17,https://pubmed.ncbi.nlm.nih.gov/30479708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,31831170,Identification of FOXE3 transcription factor as a potent oncogenic factor in triple-negative breast cancer.,2020,10.1016/j.bbrc.2019.12.034,https://pubmed.ncbi.nlm.nih.gov/31831170/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,26854927,FOXE3 mutations predispose to thoracic aortic aneurysms and dissections.,2016,10.1172/jci83778,https://pubmed.ncbi.nlm.nih.gov/26854927/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,24829271,Validation of DNA methylation biomarkers for diagnosis of acute lymphoblastic leukemia.,2014,10.1373/clinchem.2013.219956,https://pubmed.ncbi.nlm.nih.gov/24829271/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,30991053,Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia.,2019,10.1016/j.exer.2019.03.024,https://pubmed.ncbi.nlm.nih.gov/30991053/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,26862700,Functional Cloning Using a Xenopus Oocyte Expression System.,2016,10.3791/53518,https://pubmed.ncbi.nlm.nih.gov/26862700/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,26515236,A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma.,2015,10.1038/ncomms9699,https://pubmed.ncbi.nlm.nih.gov/26515236/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,29161290,Comparative analysis of weighted gene co-expression networks in human and mouse.,2017,10.1371/journal.pone.0187611,https://pubmed.ncbi.nlm.nih.gov/29161290/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXE3,ENSG00000186790,Neither,21402583,Clinical and experimental advances in congenital and paediatric cataracts.,2011,10.1098/rstb.2010.0227,https://pubmed.ncbi.nlm.nih.gov/21402583/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,41681370,Decoding the RNA Regulatory Network in Medaka (&lt;i&gt;Oryzias latipes&lt;/i&gt;) Spermatogenesis: Insights from a Germ Cell Reprogramming Model.,2026,10.3390/ani16030389,https://pubmed.ncbi.nlm.nih.gov/41681370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,40305565,Heat inducible nuclear translocation of Kdm6bb drives temperature dependent sex reversal in Nile tilapia.,2025,10.1371/journal.pgen.1011664,https://pubmed.ncbi.nlm.nih.gov/40305565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,38536778,Dmrt1 is the only male pathway gene tested indispensable for sex determination and functional testis development in tilapia.,2024,10.1371/journal.pgen.1011210,https://pubmed.ncbi.nlm.nih.gov/38536778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,39284885,Steroid hormone-deprived sex reversal in cyp11a1 mutant XX tilapia experiences an ovary-like stage at molecular level.,2024,10.1038/s42003-024-06853-8,https://pubmed.ncbi.nlm.nih.gov/39284885/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,39253718,Transcriptome analysis of four types of gonadal tissues in largemouth bass (Micropterus salmoides) to reveal its sex-related genes.,2024,10.3389/fgene.2024.1459427,https://pubmed.ncbi.nlm.nih.gov/39253718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,36450233,"Generation of Self-Fertilizing Hermaphroditic Fish from Gonochoristic Fish, Medaka (Oryzias latipes).",2022,10.1159/000526073,https://pubmed.ncbi.nlm.nih.gov/36450233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,32057909,In vitro effects of androgen on testicular development by the AR-foxl3-rec8/fbxo47 axis in orange-spotted grouper (Epinephelus coioides).,2020,10.1016/j.ygcen.2020.113435,https://pubmed.ncbi.nlm.nih.gov/32057909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,38540441,Genome-Wide Association Analysis of Semen Characteristics in Piétrain Boars.,2024,10.3390/genes15030382,https://pubmed.ncbi.nlm.nih.gov/38540441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,37879418,"Tilapia, a good model for studying reproductive endocrinology.",2024,10.1016/j.ygcen.2023.114395,https://pubmed.ncbi.nlm.nih.gov/37879418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,37998366,"Differential Expression of miRNAs, lncRNAs, and circRNAs between Ovaries and Testes in Common Carp (Cyprinus carpio).",2023,10.3390/cells12222631,https://pubmed.ncbi.nlm.nih.gov/37998366/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,38471539,Sexually dimorphic dynamics of the microtubule network in medaka (Oryzias latipes) germ cells.,2024,10.1242/dev.201840,https://pubmed.ncbi.nlm.nih.gov/38471539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,31183904,Comparison of sex determination mechanism of germ cells between birds and fish: Cloning and expression analyses of chicken forkhead box L3-like gene.,2019,10.1002/dvdy.67,https://pubmed.ncbi.nlm.nih.gov/31183904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,32214214,The transcriptome of the newt Cynops orientalis provides new insights into evolution and function of sexual gene networks in sarcopterygians.,2020,10.1038/s41598-020-62408-x,https://pubmed.ncbi.nlm.nih.gov/32214214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,32173540,Spatial and temporal expression pattern of sex-related genes in ovo-testis of the self-fertilizing mangrove killifish (Kryptolebias marmoratus).,2020,10.1016/j.gene.2020.144581,https://pubmed.ncbi.nlm.nih.gov/32173540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,30999974,Regulation of germ cell sex identity in medaka.,2019,10.1016/bs.ctdb.2019.01.010,https://pubmed.ncbi.nlm.nih.gov/30999974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,32409601,"foxl3, a sexual switch in germ cells, initiates two independent molecular pathways for commitment to oogenesis in medaka.",2020,10.1073/pnas.1918556117,https://pubmed.ncbi.nlm.nih.gov/32409601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,30594589,Expression profiles of dmrts and foxls during gonadal development and sex reversal induced by 17α-methyltestosterone in the orange-spotted grouper.,2019,10.1016/j.ygcen.2018.12.014,https://pubmed.ncbi.nlm.nih.gov/30594589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,27699806,Germline stem cells are critical for sexual fate decision of germ cells.,2016,10.1002/bies.201600045,https://pubmed.ncbi.nlm.nih.gov/27699806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,27583788,"Foxl3, a Target of miR-9, Stimulates Spermatogenesis in Spermatogonia During Natural Sex Change in Monopterus albus.",2016,10.1210/en.2016-1256,https://pubmed.ncbi.nlm.nih.gov/27583788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXL3,ENSG00000248767,Neither,30878349,"The germline-specific expression of Foxl3a and its paralogous Foxl3b are associated with male gonadal differentiation in the Japanese eel, Anguilla japonica.",2019,10.1016/j.ygcen.2019.03.008,https://pubmed.ncbi.nlm.nih.gov/30878349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,41766387,Foxn3 is part of a transcriptional network that regulates primary cilia in the developing retina.,2026,10.1242/dev.205233,https://pubmed.ncbi.nlm.nih.gov/41766387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,42537271,Unveiling the molecular basis of gonadal development: Multi-omics uncovers sex-related genes and steroid pathways in Sinonovacula constricta.,2026,10.1016/j.cbd.2026.101953,https://pubmed.ncbi.nlm.nih.gov/42537271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,41653366,Transcriptome remodeling of mouse hearts during postnatal cardiac maturation and under proteotoxic stress.,2026,10.1007/s11033-026-11535-1,https://pubmed.ncbi.nlm.nih.gov/41653366/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,40352924,The miR-941/FOXN4/TGF-β feedback loop induces N2 polarization of neutrophils and enhances tumor progression of lung adenocarcinoma.,2025,10.3389/fimmu.2025.1561081,https://pubmed.ncbi.nlm.nih.gov/40352924/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,41694697,Three Unrelated Children With Childhood Apraxia of Speech: Exome Sequencing and Functional Gene Analysis Imply a Role of Laminin-511 in Early Neurodevelopment.,2026,10.1155/crig/9927839,https://pubmed.ncbi.nlm.nih.gov/41694697/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,42361668,The role of acrylamide exposure in prostate cancer progression: An integrated analysis based on network toxicology and experimental validation.,2026,10.1016/j.ecoenv.2026.120441,https://pubmed.ncbi.nlm.nih.gov/42361668/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,41905288,Genome-wide identification and expression profiling of Fox gene family reveals the potential functions of sex determination in Crassostrea gigas.,2026,10.1016/j.cbd.2026.101819,https://pubmed.ncbi.nlm.nih.gov/41905288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,40500437,Developmental trajectory and evolutionary origin of thymic mimetic cells.,2025,10.1038/s41586-025-09148-y,https://pubmed.ncbi.nlm.nih.gov/40500437/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,37605566,FOXN4 affects myocardial ischemia-reperfusion injury through HIF-1α/MMP2-mediated ferroptosis of cardiomyocytes.,2023,10.14715/cmb/2023.69.6.33,https://pubmed.ncbi.nlm.nih.gov/37605566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,35918321,Effect of caffeine on genes expressions of developing retinas in the chick model.,2022,10.5115/acb.22.034,https://pubmed.ncbi.nlm.nih.gov/35918321/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,37449480,Forkhead transcription factor FKH-8 cooperates with RFX in the direct regulation of sensory cilia in Caenorhabditis elegans.,2023,10.7554/elife.89702,https://pubmed.ncbi.nlm.nih.gov/37449480/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,32021256,FOXN4 Inhibits Breast Cancer Progression By Direct Activation Of P53.,2020,10.2147/ott.s206775,https://pubmed.ncbi.nlm.nih.gov/32021256/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,31430519,Identification of FOXN4 as a tumor suppressor of breast carcinogenesis via the activation of TP53 and deactivation of Notch signaling.,2020,10.1016/j.gene.2019.144057,https://pubmed.ncbi.nlm.nih.gov/31430519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,37564980,Molecular mechanisms regulating natural menopause in the female ovary: a study based on transcriptomic data.,2023,10.3389/fendo.2023.1004245,https://pubmed.ncbi.nlm.nih.gov/37564980/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,34028060,Targeted sequencing reveals candidate causal variants for dairy bull subfertility.,2021,10.1111/age.13089,https://pubmed.ncbi.nlm.nih.gov/34028060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,32071204,Foxn4 is a temporal identity factor conferring mid/late-early retinal competence and involved in retinal synaptogenesis.,2020,10.1073/pnas.1918628117,https://pubmed.ncbi.nlm.nih.gov/32071204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,37255653,A seven-gene prognosis model to predict biochemical recurrence for prostate cancer based on the TCGA database.,2022,10.3389/fsurg.2022.923473,https://pubmed.ncbi.nlm.nih.gov/37255653/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,33622100,Evolution of thymopoietic microenvironments.,2021,10.1098/rsob.200383,https://pubmed.ncbi.nlm.nih.gov/33622100/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,31558434,Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures.,2019,10.1242/dev.177428,https://pubmed.ncbi.nlm.nih.gov/31558434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,36033826,"Clinical Value Screening, Prognostic Significance, and Key Gene Identification of TrkB in Laryngeal Carcinoma.",2022,10.1155/2022/1354005,https://pubmed.ncbi.nlm.nih.gov/36033826/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,37724048,Foxn1 is not essential for T-cell development in teleosts.,2023,10.1002/eji.202350725,https://pubmed.ncbi.nlm.nih.gov/37724048/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,35559013,Homologous Recombination Related Signatures Predict Prognosis and Immunotherapy Response in Metastatic Urothelial Carcinoma.,2022,10.3389/fgene.2022.875128,https://pubmed.ncbi.nlm.nih.gov/35559013/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,33447073,Identification of Four Genes as Prognosis Signatures in Lung Adenocarcinoma Microenvironment.,2021,10.2147/pgpm.s283414,https://pubmed.ncbi.nlm.nih.gov/33447073/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,25131198,"Conversion of the thymus into a bipotent lymphoid organ by replacement of FOXN1 with its paralog, FOXN4.",2014,10.1016/j.celrep.2014.07.017,https://pubmed.ncbi.nlm.nih.gov/25131198/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,21701787,A regulatory domain is required for Foxn4 activity during retinogenesis.,2012,10.1007/s12031-011-9585-4,https://pubmed.ncbi.nlm.nih.gov/21701787/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,32443726,Zygotic Vsx1 Plays a Key Role in Defining V2a Interneuron Sub-Lineage by Directly Repressing tal1 Transcription in Zebrafish.,2020,10.3390/ijms21103600,https://pubmed.ncbi.nlm.nih.gov/32443726/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,24441423,Autophagy is essential for cardiac morphogenesis during vertebrate development.,2014,10.4161/auto.27649,https://pubmed.ncbi.nlm.nih.gov/24441423/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXN4,ENSG00000139445,Neither,23285037,CD44+ cancer stem-like cells in EBV-associated nasopharyngeal carcinoma.,2012,10.1371/journal.pone.0052426,https://pubmed.ncbi.nlm.nih.gov/23285037/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,42709802,In vivo genome-wide CRISPR screens identify FOXR1 as a suppressor of CD8&lt;sup&gt;+&lt;/sup&gt; T cell antitumor immunity.,2026,10.1073/pnas.2534362123,https://pubmed.ncbi.nlm.nih.gov/42709802/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,41287519,The Transcriptional Regulator FOXR1 Is Required for Normal Early Embryogenesis but Dispensable for Male Fertility in Mice.,2025,10.1002/mrd.70071,https://pubmed.ncbi.nlm.nih.gov/41287519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,40497137,&lt;i&gt;Foxr1&lt;/i&gt; deletion causes microcephaly and leads to cortical and hippocampal hypoplasia.,2025,10.3389/fnins.2025.1589043,https://pubmed.ncbi.nlm.nih.gov/40497137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,42594540,"Effects of vitamin D&lt;sub&gt;3&lt;/sub&gt; on embryonic development, transcripts of genes encoding reproductive hormones, and its active metabolism in common carp (Cyprinus carpio L.).",2026,10.1016/j.repbio.2026.101277,https://pubmed.ncbi.nlm.nih.gov/42594540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,38927618,"Gonadal Transcriptome Sequencing Analysis Reveals the Candidate Sex-Related Genes and Signaling Pathways in the East Asian Common Octopus, &lt;i&gt;Octopus sinensis&lt;/i&gt;.",2024,10.3390/genes15060682,https://pubmed.ncbi.nlm.nih.gov/38927618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,36648026,Expanding the molecular signatures of malignant ossifying fibromyxoid tumours with two novel gene fusions: PHF1::FOXR1 and PHF1::FOXR2.,2023,10.1111/his.14868,https://pubmed.ncbi.nlm.nih.gov/36648026/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,34723967,FOXR1 regulates stress response pathways and is necessary for proper brain development.,2021,10.1371/journal.pgen.1009854,https://pubmed.ncbi.nlm.nih.gov/34723967/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,35563858,Morphological and Molecular Gonadal Sex Differentiation in the Wild Japanese eel Anguilla japonica.,2022,10.3390/cells11091554,https://pubmed.ncbi.nlm.nih.gov/35563858/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,37658696,Untying the Gordian knot of composite hemangioendothelioma: Discovery of novel fusions.,2024,10.1002/gcc.23198,https://pubmed.ncbi.nlm.nih.gov/37658696/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,35725373,"Identification, characterization and functional analysis of gonadal long noncoding RNAs in a protogynous hermaphroditic teleost fish, the ricefield eel (Monopterus albus).",2022,10.1186/s12864-022-08679-2,https://pubmed.ncbi.nlm.nih.gov/35725373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,35847864,Whole-Genome DNA Methylation Sequencing Reveals Epigenetic Changes in Myelodysplastic Syndromes.,2022,10.3389/fonc.2022.897898,https://pubmed.ncbi.nlm.nih.gov/35847864/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,37564980,Molecular mechanisms regulating natural menopause in the female ovary: a study based on transcriptomic data.,2023,10.3389/fendo.2023.1004245,https://pubmed.ncbi.nlm.nih.gov/37564980/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,34592515,"The effect of Roundup on embryonic development, early foxr1 and hsp70 gene expression and hatching of common carp (Cyprinus carpio L.).",2021,10.1016/j.theriogenology.2021.09.007,https://pubmed.ncbi.nlm.nih.gov/34592515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,30155373,foxr1 is a novel maternal-effect gene in fish that is required for early embryonic success.,2018,10.7717/peerj.5534,https://pubmed.ncbi.nlm.nih.gov/30155373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,32634160,"Differential impacts of carp and salmon pituitary extracts on induced oogenesis, egg quality, molecular ontogeny and embryonic developmental competence in European eel.",2020,10.1371/journal.pone.0235617,https://pubmed.ncbi.nlm.nih.gov/32634160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,28319194,Genome-wide analysis of brain and gonad transcripts reveals changes of key sex reversal-related genes expression and signaling pathways in three stages of Monopterus albus.,2017,10.1371/journal.pone.0173974,https://pubmed.ncbi.nlm.nih.gov/28319194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,33527450,Genetic characterisation of adult primary pleomorphic uterine rhabdomyosarcoma and comparison with uterine carcinosarcoma.,2021,10.1111/his.14346,https://pubmed.ncbi.nlm.nih.gov/33527450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,27658729,Sexually dimorphic gene expressions in eels: useful markers for early sex assessment in a conservation context.,2016,10.1038/srep34041,https://pubmed.ncbi.nlm.nih.gov/27658729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,27284737,Chromosome 11q23 aberrations activating FOXR1 in B-cell lymphoma.,2016,10.1038/bcj.2016.43,https://pubmed.ncbi.nlm.nih.gov/27284737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,33322792,Transcriptome Analyses Reveal Differential Transcriptional Profiles in Early- and Late-Dividing Porcine Somatic Cell Nuclear Transfer Embryos.,2020,10.3390/genes11121499,https://pubmed.ncbi.nlm.nih.gov/33322792/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR1,ENSG00000176302,Neither,25609838,Combining RNA and protein profiling data with network interactions identifies genes associated with spermatogenesis in mouse and human.,2015,10.1095/biolreprod.114.126250,https://pubmed.ncbi.nlm.nih.gov/25609838/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,41978643,"FOXR2-activated CNS neuroblastoma: Characterized by variable structural disruption of the &lt;i&gt;FOXR2&lt;/i&gt; regulatory region, recurrent copy number alterations, and elevated &lt;i&gt;FOXR2&lt;/i&gt; expression.",2026,10.1093/neuped/wuag014,https://pubmed.ncbi.nlm.nih.gov/41978643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,40237561,FOXR2 activation is not exclusive of CNS neuroblastoma.,2025,10.1093/neuonc/noaf076,https://pubmed.ncbi.nlm.nih.gov/40237561/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,42460216,FOXR2-Mediated CNS Neuroblastoma in a Pediatric Patient Treated With Multimodal Therapy Including Proton Craniospinal Irradiation: A Case Report.,2026,10.7759/cureus.110887,https://pubmed.ncbi.nlm.nih.gov/42460216/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,42899482,Tumour Antigen-Specific Antibody Signatures as Diagnostic Biomarkers for Melanoma.,2026,10.1002/ijc.70726,https://pubmed.ncbi.nlm.nih.gov/42899482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,39495206,FOXR2 Targets LHX6+/DLX+ Neural Lineages to Drive Central Nervous System Neuroblastoma.,2025,10.1158/0008-5472.can-24-2248,https://pubmed.ncbi.nlm.nih.gov/39495206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,41744325,"Primary CNS Neuroblastoma, FOXR2-Activated: Clinicopathological Study of Two Cases With Immunohistochemical Characterization and Literature Review.",2026,10.1111/neup.70049,https://pubmed.ncbi.nlm.nih.gov/41744325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,39866234,FOXR2 in cancer development: emerging player and therapeutic opportunities.,2025,10.32604/or.2024.052939,https://pubmed.ncbi.nlm.nih.gov/39866234/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,39552609,Aggressive Malignant Ossifying Fibromyxoid Tumor With a Rare &lt;i&gt;PHF1::FOXR2&lt;/i&gt; Fusion: A Case Report and Literature Review.,2025,10.1177/10668969241295349,https://pubmed.ncbi.nlm.nih.gov/39552609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,40348911,A novel TRKB-activating internal tandem duplication characterizes a new mechanism of receptor tyrosine kinase activation.,2025,10.1038/s41698-025-00928-3,https://pubmed.ncbi.nlm.nih.gov/40348911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,41291966,Recurrent genetic alterations in epigenetically defined pineoblastoma subtypes.,2025,10.1186/s40478-025-02140-7,https://pubmed.ncbi.nlm.nih.gov/41291966/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,37831472,Combination of serum FOXR2 and transvaginal three-dimensional power Doppler ultrasonography in the diagnosis of uterine lesions.,2024,10.17219/acem/171382,https://pubmed.ncbi.nlm.nih.gov/37831472/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,41329749,Antibody-Mediated Targeting of Secretory Protein SCUBE3 Suppresses Cancer Progression by Inhibiting Oncogenic Signaling and Inducing Antitumor Immunity.,2026,10.1158/0008-5472.can-25-0521,https://pubmed.ncbi.nlm.nih.gov/41329749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,42058762,Genetic landscape and molecular targets in pediatric pineal tumors.,2026,10.1093/noajnl/vdag086,https://pubmed.ncbi.nlm.nih.gov/42058762/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,38840609,Pediatric central nervous system (CNS) neuroblastoma: A case report.,2024,10.25259/sni_794_2023,https://pubmed.ncbi.nlm.nih.gov/38840609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,41954087,Role of Surrogate Immunohistochemistry Markers in CNS Tumors in the Era of Molecular Diagnostics With Recent Updates.,2026,10.1097/pap.0000000000000533,https://pubmed.ncbi.nlm.nih.gov/41954087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,39220247,A human embryonic stem cell-based model reveals the cell of origin of FOXR2-activated CNS neuroblastoma.,2024,10.1093/noajnl/vdae144,https://pubmed.ncbi.nlm.nih.gov/39220247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,35802025,FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits.,2022,10.1158/0008-5472.can-22-0671,https://pubmed.ncbi.nlm.nih.gov/35802025/,normal | therapy,Discussed in explicit gene adjudication; see its review depth and limitations
FOXR2,ENSG00000189299,Neither,41274772,Central Nervous System Embryonal Tumors.,2026,10.1016/j.nic.2025.08.007,https://pubmed.ncbi.nlm.nih.gov/41274772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,37879492,Insights into the molecular roles of FOXR2 in the pathology of primary pediatric brain tumors.,2023,10.1016/j.critrevonc.2023.104188,https://pubmed.ncbi.nlm.nih.gov/37879492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,35403869,Somatic LINE-1 promoter acquisition drives oncogenic FOXR2 activation in pediatric brain tumor.,2022,10.1007/s00401-022-02420-9,https://pubmed.ncbi.nlm.nih.gov/35403869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,33839405,E3 ubiquitin ligase PJA1 regulates lung adenocarcinoma apoptosis and invasion through promoting FOXR2 degradation.,2021,10.1016/j.bbrc.2021.03.137,https://pubmed.ncbi.nlm.nih.gov/33839405/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,35651928,FTX Regulated miR-153-3p/FOXR2 to Promote Cisplatin Resistance in Ovarian Cancer.,2022,10.1155/2022/2318170,https://pubmed.ncbi.nlm.nih.gov/35651928/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,34077956,"Therapeutic implications of improved molecular diagnostics for rare CNS embryonal tumor entities: results of an international, retrospective study.",2021,10.1093/neuonc/noab136,https://pubmed.ncbi.nlm.nih.gov/34077956/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,31761897,Forkhead Box R2 Knockdown Decreases Chemoresistance to Cisplatin via MYC Pathway in Bladder Cancer.,2019,10.12659/msm.917345,https://pubmed.ncbi.nlm.nih.gov/31761897/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,33619588,Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study.,2021,10.1007/s00401-021-02284-5,https://pubmed.ncbi.nlm.nih.gov/33619588/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,38439957,EPC1/2 regulate hematopoietic stem and progenitor cell proliferation by modulating H3 acetylation and DLST.,2024,10.1016/j.isci.2024.109263,https://pubmed.ncbi.nlm.nih.gov/38439957/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,32650833,"Molecular identification of CNS NB-FOXR2, CNS EFT-CIC, CNS HGNET-MN1 and CNS HGNET-BCOR pediatric brain tumors using tumor-specific signature genes.",2020,10.1186/s40478-020-00984-9,https://pubmed.ncbi.nlm.nih.gov/32650833/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,38500181,Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion.,2024,10.1186/s40478-024-01746-7,https://pubmed.ncbi.nlm.nih.gov/38500181/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,31802236,"Risk-adapted therapy and biological heterogeneity in pineoblastoma: integrated clinico-pathological analysis from the prospective, multi-center SJMB03 and SJYC07 trials.",2020,10.1007/s00401-019-02106-9,https://pubmed.ncbi.nlm.nih.gov/31802236/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,35982322,Molecular classification and outcome of children with rare CNS embryonal tumors: results from St. Jude Children's Research Hospital including the multi-center SJYC07 and SJMB03 clinical trials.,2022,10.1007/s00401-022-02484-7,https://pubmed.ncbi.nlm.nih.gov/35982322/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,30674530,Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors.,2019,10.1158/0008-5472.can-18-1261,https://pubmed.ncbi.nlm.nih.gov/30674530/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,31945729,circCELSR1 (hsa_circ_0063809) Contributes to Paclitaxel Resistance of Ovarian Cancer Cells by Regulating FOXR2 Expression via miR-1252.,2020,10.1016/j.omtn.2019.12.005,https://pubmed.ncbi.nlm.nih.gov/31945729/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXR2,ENSG00000189299,Neither,15202009,"Identification and characterization of human FOXN6, mouse Foxn6, and rat Foxn6 genes in silico.",2004,10.3892/ijo.25.1.219,https://pubmed.ncbi.nlm.nih.gov/15202009/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTHL17,ENSG00000132446,Neither,42425085,Overlapping Xq13.3 duplications define an X-linked hypotrichosis simplex and implicate TAB3 dosage sensitivity.,2026,10.1016/j.ajhg.2026.06.013,https://pubmed.ncbi.nlm.nih.gov/42425085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTHL17,ENSG00000132446,Neither,42089935,MSI1-FTHL17C-iron circuit couples metabolic and epigenetic control of pluripotency in mouse embryonic stem cells.,2026,10.1186/s13619-026-00288-8,https://pubmed.ncbi.nlm.nih.gov/42089935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTHL17,ENSG00000132446,Neither,38187237,"FTHL17, PRM2, CABYR, CPXCR1, ADAM29, and CABS1 are highly expressed in colon cancer patients and are regulated in vitro by epigenetic alterations.",2024,10.1016/j.heliyon.2023.e23689,https://pubmed.ncbi.nlm.nih.gov/38187237/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTHL17,ENSG00000132446,Neither,28207785,DNA methylation of the Fthl17 5'-upstream region regulates differential Fthl17 expression in lung cancer cells and germline stem cells.,2017,10.1371/journal.pone.0172219,https://pubmed.ncbi.nlm.nih.gov/28207785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTHL17,ENSG00000132446,Neither,30922653,"Novel mutation in FTHL17 gene in pedigree with 46,XY pure gonadal dysgenesis.",2019,10.1016/j.fertnstert.2019.01.027,https://pubmed.ncbi.nlm.nih.gov/30922653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTHL17,ENSG00000132446,Neither,35737091,Whole-exome sequencing of Indian prostate cancer reveals a novel therapeutic target: POLQ.,2023,10.1007/s00432-022-04111-0,https://pubmed.ncbi.nlm.nih.gov/35737091/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTHL17,ENSG00000132446,Neither,29577858,Expression and Prognostic Relevance of GAGE1 and XAGE1 Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma.,2017,10.2174/1566524018666180322162145,https://pubmed.ncbi.nlm.nih.gov/29577858/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTHL17,ENSG00000132446,Neither,25749565,The Ferritin-Heavy-Polypeptide-Like-17 (FTHL17) gene encodes a ferritin with low stability and no ferroxidase activity and with a partial nuclear localization.,2015,10.1016/j.bbagen.2015.02.016,https://pubmed.ncbi.nlm.nih.gov/25749565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTHL17,ENSG00000132446,Neither,20185572,The X-linked imprinted gene family Fthl17 shows predominantly female expression following the two-cell stage in mouse embryos.,2010,10.1093/nar/gkq113,https://pubmed.ncbi.nlm.nih.gov/20185572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTHL17,ENSG00000132446,Neither,23301059,Exome capture sequencing of adenoma reveals genetic alterations in multiple cellular pathways at the early stage of colorectal tumorigenesis.,2013,10.1371/journal.pone.0053310,https://pubmed.ncbi.nlm.nih.gov/23301059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTHL17,ENSG00000132446,Neither,16929165,Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma.,2006,10.4161/cbt.5.9.3174,https://pubmed.ncbi.nlm.nih.gov/16929165/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTHL17,ENSG00000132446,Neither,14531651,Molecular and cytogenetic characterization of two azoospermic patients with X-autosome translocation.,2003,10.1023/a:1025437329427,https://pubmed.ncbi.nlm.nih.gov/14531651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FTHL17,ENSG00000132446,Neither,12704671,Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia.,2003,10.1002/ijc.11104,https://pubmed.ncbi.nlm.nih.gov/12704671/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,41737476,The role of neighborhood factors in the cumulative number of episodes of recurrent tuberculosis in Cape Town.,2026,10.1016/j.jctube.2026.100591,https://pubmed.ncbi.nlm.nih.gov/41737476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,39606642,Bioinformatics Analysis and Experimental Validation to Identify Key Glycosylation-Related Genes in Asthma.,2024,10.2147/jir.s484542,https://pubmed.ncbi.nlm.nih.gov/39606642/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,42500337,Transcriptional Scenario of Altered Glycosylation in HPV-Associated Cervical Cancer.,2026,10.1007/s12291-024-01280-2,https://pubmed.ncbi.nlm.nih.gov/42500337/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,37435017,Fucosyltransferase 5 Promotes the Proliferative and Migratory Properties of Intrahepatic Cholangiocarcinoma Cells via Regulating Protein Glycosylation Profiles.,2023,10.1177/11795549231181189,https://pubmed.ncbi.nlm.nih.gov/37435017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,39911230,Identification of potential druggable targets for endometriosis through Mendelian randomization analysis.,2024,10.3389/fendo.2024.1371498,https://pubmed.ncbi.nlm.nih.gov/39911230/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,40236777,"Phenotyping, genome-wide dissection, and prediction of maize root architecture for temperate adaptability.",2025,10.1002/imt2.70015,https://pubmed.ncbi.nlm.nih.gov/40236777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,41744063,Hypofucosylation promotes pertussis toxin binding to cell surface glycococonjugates and pertussis toxin-induced intracellular ERK signaling.,2026,10.1093/glycob/cwag011,https://pubmed.ncbi.nlm.nih.gov/41744063/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,34703796,Altered mRNA Expression of Fucosyltransferases and Fucosidase Predicts Prognosis in Human Oral Carcinoma.,2021,10.22088/ijmcm.bums.10.2.123,https://pubmed.ncbi.nlm.nih.gov/34703796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,34172473,Genetically increased circulating FUT3 level leads to reduced risk of idiopathic pulmonary fibrosis: a Mendelian randomisation study.,2022,10.1183/13993003.03979-2020,https://pubmed.ncbi.nlm.nih.gov/34172473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,33238851,Curbing the Deregulation of Glycosylation in Tongue Carcinoma Cells with Natural Compounds.,2021,10.2174/1871520620999201124213259,https://pubmed.ncbi.nlm.nih.gov/33238851/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,28771224,"miR-125a-3p/FUT5-FUT6 axis mediates colorectal cancer cell proliferation, migration, invasion and pathological angiogenesis via PI3K-Akt pathway.",2017,10.1038/cddis.2017.352,https://pubmed.ncbi.nlm.nih.gov/28771224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,36410685,Outcomes Stratification of Head and Neck Cancer Using Pre- and Post-treatment DNA Methylation From Peripheral Blood.,2023,10.1016/j.ijrobp.2022.11.009,https://pubmed.ncbi.nlm.nih.gov/36410685/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,33148303,High-throughput screening reveals novel mutations in spinal muscular atrophy patients.,2020,10.1186/s13052-020-00925-1,https://pubmed.ncbi.nlm.nih.gov/33148303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,28973293,"NFκB-mediated activation of the cellular FUT3, 5 and 6 gene cluster by herpes simplex virus type 1.",2017,10.1093/glycob/cwx079,https://pubmed.ncbi.nlm.nih.gov/28973293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,32631391,Dysregulation of cancer genes by recurrent intergenic fusions.,2020,10.1186/s13059-020-02076-2,https://pubmed.ncbi.nlm.nih.gov/32631391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,34187466,Multivariate transcriptome analysis identifies networks and key drivers of chronic lymphocytic leukemia relapse risk and patient survival.,2021,10.1186/s12920-021-01012-y,https://pubmed.ncbi.nlm.nih.gov/34187466/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,22619806,[Distribution specificity of human fucosyltransferase 5 and its expression and localization in spermatids].,2012,,https://pubmed.ncbi.nlm.nih.gov/22619806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,34156094,Estimation of Lewis-negative alleles by high-resolution melting analysis of three tag SNPs of FUT3.,2022,10.1111/vox.13168,https://pubmed.ncbi.nlm.nih.gov/34156094/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,21978830,Down-regulation of FUT3 and FUT5 by shRNA alters Lewis antigens expression and reduces the adhesion capacities of gastric cancer cells.,2011,10.1016/j.bbagen.2011.09.011,https://pubmed.ncbi.nlm.nih.gov/21978830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,29215790,"Inhibition of fucosylation in human invasive ductal carcinoma reduces E-selectin ligand expression, cell proliferation, and ERK1/2 and p38 MAPK activation.",2018,10.1002/1878-0261.12163,https://pubmed.ncbi.nlm.nih.gov/29215790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FUT5,ENSG00000130383,Neither,23144050,Virus-induced appearance of the selectin ligand sLeX in herpes simplex virus type 1-infected T-cells: involvement of host and viral factors.,2013,10.1093/glycob/cws160,https://pubmed.ncbi.nlm.nih.gov/23144050/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAB4,ENSG00000215568,Neither,37990144,Probable human origin of the SARS-CoV-2 polybasic furin cleavage motif.,2023,10.1186/s12863-023-01169-8,https://pubmed.ncbi.nlm.nih.gov/37990144/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAB4,ENSG00000215568,Neither,22984489,New strain of simian immunodeficiency virus identified in wild-born chimpanzees from central Africa.,2012,10.1371/journal.pone.0044298,https://pubmed.ncbi.nlm.nih.gov/22984489/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE10,ENSG00000215274,Neither,31892350,An epigenome-wide association study of sex-specific chronological ageing.,2019,10.1186/s13073-019-0693-z,https://pubmed.ncbi.nlm.nih.gov/31892350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE10,ENSG00000215274,Neither,33181260,Association of FOXP3 and GAGE10 promoter polymorphisms and decreased FOXP3 expression in regulatory T cells with susceptibility to generalized vitiligo in Gujarat population.,2021,10.1016/j.gene.2020.145295,https://pubmed.ncbi.nlm.nih.gov/33181260/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE10,ENSG00000215274,Neither,20872948,Identification of novel gastric cancer-associated CNVs by integrated analysis of microarray.,2010,10.1002/jso.21585,https://pubmed.ncbi.nlm.nih.gov/20872948/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,40183073,Corrigendum: Astragalus-Scorpion drug pair inhibits the development of prostate cancer by regulating GDPD4-2/PI3K/AKT/mTOR pathway and autophagy.,2025,10.3389/fphar.2025.1417603,https://pubmed.ncbi.nlm.nih.gov/40183073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,37025379,GDE6 promotes progenitor identity in the vertebrate neural tube.,2023,10.3389/fnins.2023.1047767,https://pubmed.ncbi.nlm.nih.gov/37025379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,35847007,Astragalus-Scorpion Drug Pair Inhibits the Development of Prostate Cancer by Regulating GDPD4-2/PI3K/AKT/mTOR Pathway and Autophagy.,2022,10.3389/fphar.2022.895696,https://pubmed.ncbi.nlm.nih.gov/35847007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,40841065,Wetland types shape microbial function related to soil phosphorus cycling based on metagenomics analysis.,2025,10.1016/j.jes.2025.03.009,https://pubmed.ncbi.nlm.nih.gov/40841065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,37980948,Mechanisms of total phosphorus removal and reduction of β-lactam antibiotic resistance genes by exogenous fungal combination activated sludge.,2024,10.1016/j.biortech.2023.130046,https://pubmed.ncbi.nlm.nih.gov/37980948/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,35182431,Tiki proteins are glycosylphosphatidylinositol-anchored proteases.,2022,10.1002/1873-3468.14320,https://pubmed.ncbi.nlm.nih.gov/35182431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,31455729,Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice.,2019,10.1073/pnas.1908736116,https://pubmed.ncbi.nlm.nih.gov/31455729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,36181699,Moderate salinity improves the availability of soil P by regulating P-cycling microbial communities in coastal wetlands.,2023,10.1111/gcb.16465,https://pubmed.ncbi.nlm.nih.gov/36181699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,27351883,"In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug resistance-reverting agents.",2016,10.1007/s00210-016-1266-y,https://pubmed.ncbi.nlm.nih.gov/27351883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,15276213,"Isolation and characterization of two serpentine membrane proteins containing glycerophosphodiester phosphodiesterase, GDE2 and GDE6.",2004,10.1016/j.gene.2004.04.026,https://pubmed.ncbi.nlm.nih.gov/15276213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,18083802,"Escherichia coli cytosolic glycerophosphodiester phosphodiesterase (UgpQ) requires Mg2+, Co2+, or Mn2+ for its enzyme activity.",2008,10.1128/jb.01223-07,https://pubmed.ncbi.nlm.nih.gov/18083802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,27421018,Exome sequencing in Thai patients with familial obesity.,2016,10.4238/gmr.15028311,https://pubmed.ncbi.nlm.nih.gov/27421018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,17690467,Mammalian glycerophosphodiester phosphodiesterases.,2007,10.1271/bbb.70062,https://pubmed.ncbi.nlm.nih.gov/17690467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,17874165,Cellular responses and proteomic analysis of Escherichia coli exposed to green tea polyphenols.,2007,10.1007/s00284-007-9021-8,https://pubmed.ncbi.nlm.nih.gov/17874165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,19926862,Subcellular localization of marine bacterial alkaline phosphatases.,2009,10.1073/pnas.0907586106,https://pubmed.ncbi.nlm.nih.gov/19926862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,8755898,Spontaneous and induced mutations in a single open reading frame alter both virulence and avirulence in Xanthomonas campestris pv. vesicatoria avrBs2.,1996,10.1128/jb.178.15.4661-4669.1996,https://pubmed.ncbi.nlm.nih.gov/8755898/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,2842304,Characteristics of a ugp-encoded and phoB-dependent glycerophosphoryl diester phosphodiesterase which is physically dependent on the ugp transport system of Escherichia coli.,1988,10.1128/jb.170.9.4125-4135.1988,https://pubmed.ncbi.nlm.nih.gov/2842304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,9393724,"Characterization of the acc operon from the nopaline-type Ti plasmid pTiC58, which encodes utilization of agrocinopines A and B and susceptibility to agrocin 84.",1997,10.1128/jb.179.23.7559-7572.1997,https://pubmed.ncbi.nlm.nih.gov/9393724/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD4,ENSG00000178795,Neither,1718947,The Staphylococcus aureus mec determinant comprises an unusual cluster of direct repeats and codes for a gene product similar to the Escherichia coli sn-glycerophosphoryl diester phosphodiesterase.,1991,10.1128/jb.173.23.7416-7422.1991,https://pubmed.ncbi.nlm.nih.gov/1718947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GFY,ENSG00000261949,Neither,42294802,Goofy/123Cre lineage tracing differentiates olfactory and vomeronasal neurons from GnRH-1 and terminal nerve neurons during neuronal migration and reveals additional olfactory placode-derived cells in the brain.,2026,10.1002/dvdy.70164,https://pubmed.ncbi.nlm.nih.gov/42294802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GFY,ENSG00000261949,Neither,41125435,Identifying Key Regulators in Odorant Receptor Trafficking.,2025,10.1523/jneurosci.0454-25.2025,https://pubmed.ncbi.nlm.nih.gov/41125435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GFY,ENSG00000261949,Neither,39376611,Analysis of chromatin accessibility in peripheral blood mononuclear cells from patients with early-stage breast cancer.,2024,10.3389/fphar.2024.1465586,https://pubmed.ncbi.nlm.nih.gov/39376611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GFY,ENSG00000261949,Neither,38966291,SMARCB1-Retained and SMARCB1-Deficient SNUC are Genetically Distinct: A Pilot Study Using RNA Sequencing.,2024,10.1055/a-2088-6730,https://pubmed.ncbi.nlm.nih.gov/38966291/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GFY,ENSG00000261949,Neither,34938502,Exome sequencing of deer mice on two California Channel Islands identifies potential adaptation to strongly contrasting ecological conditions.,2021,10.1002/ece3.8357,https://pubmed.ncbi.nlm.nih.gov/34938502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GFY,ENSG00000261949,Neither,31245784,Characterization of the GPR1/FUN34/YaaH protein family in the green microalga Chlamydomonas suggests their role as intracellular membrane acetate channels.,2019,10.1002/pld3.148,https://pubmed.ncbi.nlm.nih.gov/31245784/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GFY,ENSG00000261949,Neither,30402224,Identification of 26 novel loci that confer susceptibility to early-onset coronary artery disease in a Japanese population.,2018,10.3892/br.2018.1152,https://pubmed.ncbi.nlm.nih.gov/30402224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GFY,ENSG00000261949,Neither,16941565,Analysis of the CD2 and spliceosomal Sm B/B' polyproline-arginine motifs defined by a monoclonal antibody using a phage-displayed random peptide library.,2006,10.1002/jmr.800,https://pubmed.ncbi.nlm.nih.gov/16941565/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GFY,ENSG00000261949,Neither,8757726,"Mutagenesis of three surface-exposed loops of a Bacillus thuringiensis insecticidal toxin reveals residues important for toxicity, receptor recognition and possibly membrane insertion.",1996,10.1099/13500872-142-7-1617,https://pubmed.ncbi.nlm.nih.gov/8757726/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA10,ENSG00000135355,Neither,40045892,Inter-platelet communication driving thrombus formation is regulated by extracellular calpain-1 cleavage of connexin 62.,2025,10.3324/haematol.2024.286466,https://pubmed.ncbi.nlm.nih.gov/40045892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA10,ENSG00000135355,Neither,39800318,In-depth computational analysis reveals the significant dysregulation of key gap junction proteins (GJPs) driving thoracic aortic aneurysm development.,2025,10.1016/j.hjc.2025.01.001,https://pubmed.ncbi.nlm.nih.gov/39800318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA10,ENSG00000135355,Neither,35053163,Connexin 43 Gene Ablation Does Not Alter Human Pluripotent Stem Cell Germ Lineage Specification.,2021,10.3390/biom12010015,https://pubmed.ncbi.nlm.nih.gov/35053163/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA10,ENSG00000135355,Neither,32822477,"Structural, functional, and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets.",2021,10.1182/blood.2019004575,https://pubmed.ncbi.nlm.nih.gov/32822477/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA10,ENSG00000135355,Neither,35240197,Form-deprivation myopia downregulates calcium levels in retinal horizontal cells in mice.,2022,10.1016/j.exer.2022.109018,https://pubmed.ncbi.nlm.nih.gov/35240197/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA10,ENSG00000135355,Neither,32952657,Long non-coding RNAs lnc-ANGPTL1-3:3 and lnc-GJA10-12:1 present as regulators of sentinel lymph node metastasis in breast cancer.,2020,10.3892/ol.2020.12050,https://pubmed.ncbi.nlm.nih.gov/32952657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA10,ENSG00000135355,Neither,33818243,Mind the gap: connexins and pannexins in platelet function.,2021,10.1080/09537104.2021.1902971,https://pubmed.ncbi.nlm.nih.gov/33818243/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA10,ENSG00000135355,Neither,31423234,Prognostic value of the mRNA expression of gap junction α members in patients with gastric cancer.,2019,10.3892/ol.2019.10516,https://pubmed.ncbi.nlm.nih.gov/31423234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA10,ENSG00000135355,Neither,20979653,Expression of connexin genes in the human retina.,2010,10.1186/1471-2415-10-27,https://pubmed.ncbi.nlm.nih.gov/20979653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA10,ENSG00000135355,Neither,35401882,Comprehensive Analysis of Colorectal Cancer Immunity and Identification of Immune-Related Prognostic Targets.,2022,10.1155/2022/7932655,https://pubmed.ncbi.nlm.nih.gov/35401882/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA10,ENSG00000135355,Neither,30048782,An Alternative Splice Variant of Zebrafish Cx52.6 is Expressed in Retinal Horizontal Cells.,2018,10.1016/j.neuroscience.2018.07.024,https://pubmed.ncbi.nlm.nih.gov/30048782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA10,ENSG00000135355,Neither,33276007,Whole-genome sequencing to identify candidate genes for litter size and to uncover the variant function in goats (Capra hircus).,2021,10.1016/j.ygeno.2020.11.024,https://pubmed.ncbi.nlm.nih.gov/33276007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA10,ENSG00000135355,Neither,23874796,Independent losses of visual perception genes Gja10 and Rbp3 in echolocating bats (Order: Chiroptera).,2013,10.1371/journal.pone.0068867,https://pubmed.ncbi.nlm.nih.gov/23874796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA10,ENSG00000135355,Neither,22796289,Connexin hemichannel mediated ephaptic inhibition in the retina.,2012,10.1016/j.brainres.2012.04.059,https://pubmed.ncbi.nlm.nih.gov/22796289/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA10,ENSG00000135355,Neither,12881038,"Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues.",2003,10.1080/15419060302063,https://pubmed.ncbi.nlm.nih.gov/12881038/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,41008556,Glycerol Kinase 2 as a Metabolic Sentinel for Human Sperm Motility and Male Fertility.,2025,10.3390/biom15091249,https://pubmed.ncbi.nlm.nih.gov/41008556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,41285782,The S-depalmitoylase ABHD10 is essential for sperm mitochondrial sheath formation and male fertility.,2025,10.1038/s41467-025-65300-2,https://pubmed.ncbi.nlm.nih.gov/41285782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,39641080,Differential gene expression analysis supports dysregulation of mitochondrial activity as a new perspective for glioblastoma's aggressiveness.,2024,10.1016/j.heliyon.2024.e40414,https://pubmed.ncbi.nlm.nih.gov/39641080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,37216344,Impact of divergence of residual feed intake on triglyceride metabolism-related gene expression in meat-type ducks.,2023,10.1371/journal.pone.0286051,https://pubmed.ncbi.nlm.nih.gov/37216344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,40783785,METTL5 deficiency induces oligoasthenoteratozoospermia via impaired 18S rRNA m&lt;sup&gt;6&lt;/sup&gt;A methylation in humans and mice.,2025,10.1016/j.ymthe.2025.08.009,https://pubmed.ncbi.nlm.nih.gov/40783785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,40032874,Dynamic response characteristics of tunnel linings at varied burial depths in landslide systems under seismic loading.,2025,10.1038/s41598-025-89774-8,https://pubmed.ncbi.nlm.nih.gov/40032874/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,37976321,A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex.,2023,10.1371/journal.ppat.1011781,https://pubmed.ncbi.nlm.nih.gov/37976321/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,36688733,Protective effect of GK2 fused BLVRA protein against oxidative stress-induced dopaminergic neuronal cell damage.,2023,10.1111/febs.16721,https://pubmed.ncbi.nlm.nih.gov/36688733/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,38146226,"Dipotassium glycyrrhizate and hinokitiol enhance macrophage efferocytosis by regulating recognition, uptake, and metabolism of apoptotic cells in vitro.",2024,10.1111/jre.13228,https://pubmed.ncbi.nlm.nih.gov/38146226/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,41906075,Unveiling genetic diversity and population structure in jackfruit (Artocarpus heterophyllus) through SNP markers for enhanced breeding and conservation.,2026,10.1186/s12870-026-08518-6,https://pubmed.ncbi.nlm.nih.gov/41906075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,37510361,Molecular Regulation of Differential Lipid Molecule Accumulation in the Intramuscular Fat and Abdominal Fat of Chickens.,2023,10.3390/genes14071457,https://pubmed.ncbi.nlm.nih.gov/37510361/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,33536340,ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility.,2021,10.1073/pnas.2018355118,https://pubmed.ncbi.nlm.nih.gov/33536340/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,34904747,"Glycerol biosynthesis plays an essential role in mediating cold tolerance the red imported fire ant, Solenopsis invicta.",2022,10.1002/arch.21861,https://pubmed.ncbi.nlm.nih.gov/34904747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,38998429,Dynamic Adhesive Behavior and Biofilm Formation of Staphylococcus aureus on Polylactic Acid Surfaces in Diabetic Environments.,2024,10.3390/ma17133349,https://pubmed.ncbi.nlm.nih.gov/38998429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,35260770,"Cold tolerance strategies of the fall armyworm, Spodoptera frugiperda (Smith) (Lepidoptera: Noctuidae).",2022,10.1038/s41598-022-08174-4,https://pubmed.ncbi.nlm.nih.gov/35260770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,30662012,Glycerol kinase 2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis.,2019,10.1262/jrd.2018-136,https://pubmed.ncbi.nlm.nih.gov/30662012/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,28852571,Glycerol kinase-like proteins cooperate with Pld6 in regulating sperm mitochondrial sheath formation and male fertility.,2017,10.1038/celldisc.2017.30,https://pubmed.ncbi.nlm.nih.gov/28852571/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,34066170,Genetic and Epigenetic Alterations of CDH1 Regulatory Regions in Hereditary and Sporadic Gastric Cancer.,2021,10.3390/ph14050457,https://pubmed.ncbi.nlm.nih.gov/34066170/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,33600092,"Evaluation of a Cetylpyridinium Chloride-, Dipotassium Glycyrrhizinate-, and Tranexamic Acid-based Mouthwash after Implant Placement: A Double-blind Randomised Clinical Trial.",2021,10.3290/j.ohpd.b966793,https://pubmed.ncbi.nlm.nih.gov/33600092/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,31469419,Identification of novel epithelial ovarian cancer loci in women of African ancestry.,2020,10.1002/ijc.32653,https://pubmed.ncbi.nlm.nih.gov/31469419/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,36230223,"Vegan Ice Cream Made from Soy Extract, Soy Kefir and Jaboticaba Peel: Antioxidant Capacity and Sensory Profile.",2022,10.3390/foods11193148,https://pubmed.ncbi.nlm.nih.gov/36230223/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,25486568,Cyclin B3 and dynein heavy chain cooperate to increase fitness in the absence of mdf-1/MAD1 in Caenorhabditis elegans.,2014,10.4161/15384101.2014.949491,https://pubmed.ncbi.nlm.nih.gov/25486568/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,25632271,Anti-inflammatory effects of adenosine N1-oxide.,2015,10.1186/s12950-014-0045-0,https://pubmed.ncbi.nlm.nih.gov/25632271/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,16751426,Molecular characterization of the anti-idiotypic immune response of a relapse-free neuroblastoma patient following antibody therapy: a possible vaccine against tumors of neuroectodermal origin?,2006,10.4049/jimmunol.176.12.7775,https://pubmed.ncbi.nlm.nih.gov/16751426/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK2,ENSG00000196475,Neither,20015197,Low-dose taxotere enhances the ability of sorafenib to induce apoptosis in gastric cancer models.,2011,10.1111/j.1582-4934.2009.00993.x,https://pubmed.ncbi.nlm.nih.gov/20015197/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK3,ENSG00000229894,Neither,40032874,Dynamic response characteristics of tunnel linings at varied burial depths in landslide systems under seismic loading.,2025,10.1038/s41598-025-89774-8,https://pubmed.ncbi.nlm.nih.gov/40032874/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK3,ENSG00000229894,Neither,39661296,Neuroprotective Assessment of Nutraceutical (Betanin) in Neuroblastoma Cell Line SHSY-5Y: An in-Vitro and in-Silico Approach.,2024,10.1007/s11064-024-04312-8,https://pubmed.ncbi.nlm.nih.gov/39661296/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK3,ENSG00000229894,Neither,38982547,Discovery of antimalarial drugs from secondary metabolites in actinomycetes culture library.,2024,10.1186/s41182-024-00608-1,https://pubmed.ncbi.nlm.nih.gov/38982547/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK3,ENSG00000229894,Neither,37051932,A Combination of Distinct Vascular Stem/Progenitor Cells for Neovascularization and Ischemic Rescue.,2023,10.1161/atvbaha.122.317943,https://pubmed.ncbi.nlm.nih.gov/37051932/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK3,ENSG00000229894,Neither,36230223,"Vegan Ice Cream Made from Soy Extract, Soy Kefir and Jaboticaba Peel: Antioxidant Capacity and Sensory Profile.",2022,10.3390/foods11193148,https://pubmed.ncbi.nlm.nih.gov/36230223/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK3,ENSG00000229894,Neither,17898051,A recombinant herpes simplex virus type 1 expressing two additional copies of gK is more pathogenic than wild-type virus in two different strains of mice.,2007,10.1128/jvi.01442-07,https://pubmed.ncbi.nlm.nih.gov/17898051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GK3,ENSG00000229894,Neither,19402252,Tuber-specific expression of a yeast invertase  and a bacterial glucokinase in potato leads to an activation  of sucrose phosphate synthase and the creation  of a sucrose futile cycle.,1999,10.1007/s004250050554,https://pubmed.ncbi.nlm.nih.gov/19402252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLT6D1,ENSG00000204007,Neither,42763709,GLT6D1 rs1537415 G Allele and Advanced Periodontitis: A Meta-Analysis.,2026,10.7759/cureus.114871,https://pubmed.ncbi.nlm.nih.gov/42763709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLT6D1,ENSG00000204007,Neither,32561905,CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity.,2020,10.1093/biolre/ioaa084,https://pubmed.ncbi.nlm.nih.gov/32561905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLT6D1,ENSG00000204007,Neither,35703703,Analysis of GLT6D1 and CDKN2BAS gene polymorphisms in Brazilian patients with advanced periodontitis.,2022,10.1590/1807-3107bor-2022.vol36.0077,https://pubmed.ncbi.nlm.nih.gov/35703703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLT6D1,ENSG00000204007,Neither,28044107,Molecular Evolution of the Glycosyltransferase 6 Gene Family in Primates.,2016,10.1155/2016/9051727,https://pubmed.ncbi.nlm.nih.gov/28044107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLT6D1,ENSG00000204007,Neither,34515563,Exome Sequencing of 5 Families with Severe Early-Onset Periodontitis.,2022,10.1177/00220345211029266,https://pubmed.ncbi.nlm.nih.gov/34515563/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLT6D1,ENSG00000204007,Neither,30030838,"Validation of reported GLT6D1 (rs1537415), IL10 (rs6667202), and ANRIL (rs1333048) single nucleotide polymorphisms for aggressive periodontitis in a Brazilian population.",2019,10.1002/jper.18-0071,https://pubmed.ncbi.nlm.nih.gov/30030838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLT6D1,ENSG00000204007,Neither,31117955,A genome-wide association study reveals specific transferases as candidate loci for bovine milk oligosaccharides synthesis.,2019,10.1186/s12864-019-5786-y,https://pubmed.ncbi.nlm.nih.gov/31117955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLT6D1,ENSG00000204007,Neither,29105764,Genetic polymorphisms and periodontal disease in populations of African descent: A review.,2018,10.1111/jre.12505,https://pubmed.ncbi.nlm.nih.gov/29105764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLT6D1,ENSG00000204007,Neither,19897590,A genome-wide association study identifies GLT6D1 as a susceptibility locus for periodontitis.,2010,10.1093/hmg/ddp508,https://pubmed.ncbi.nlm.nih.gov/19897590/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOLGA6B,ENSG00000215186,Neither,41957852,Genome-wide copy-number analysis improves detection of pathogenic AZFc and autosomal variants in idiopathic non-obstructive azoospermia.,2026,10.1186/s13039-026-00758-3,https://pubmed.ncbi.nlm.nih.gov/41957852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOLGA6B,ENSG00000215186,Neither,37508488,Golgi Apparatus Target Proteins in Gastroenterological Cancers: A Comprehensive Review of GOLPH3 and GOLGA Proteins.,2023,10.3390/cells12141823,https://pubmed.ncbi.nlm.nih.gov/37508488/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOLGA6L1,ENSG00000273976,Neither,32141150,New genetic variations discovered in KRAS wild-type cetuximab resistant chinese colorectal cancer patients.,2020,10.1002/mc.23172,https://pubmed.ncbi.nlm.nih.gov/32141150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOLGA6L6,ENSG00000277322,Neither,39863862,Identification of novel cytoskeleton protein involved in spermatogenic cells and sertoli cells of non-obstructive azoospermia based on microarray and bioinformatics analysis.,2025,10.1186/s12920-025-02087-7,https://pubmed.ncbi.nlm.nih.gov/39863862/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOLGA6L6,ENSG00000277322,Neither,38376367,A genome-wide CRISPR screen identified host genes essential for intracellular &lt;i&gt;Brucella&lt;/i&gt; survival.,2024,10.1128/spectrum.03383-23,https://pubmed.ncbi.nlm.nih.gov/38376367/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOT1L1,ENSG00000169154,Neither,42198828,Single-Embryo RNA Sequencing Reveals Transcriptomic Alterations in Blastocysts Derived From IVM or Vitrified Oocytes.,2026,10.1002/mrd.70116,https://pubmed.ncbi.nlm.nih.gov/42198828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOT1L1,ENSG00000169154,Neither,37644531,Malakoplakia with aberrant ALK expression by immunohistochemistry: a case report.,2023,10.1186/s13000-023-01383-z,https://pubmed.ncbi.nlm.nih.gov/37644531/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOT1L1,ENSG00000169154,Neither,35751016,Ectopic expression of a combination of 5 genes detects high risk forms of T-cell acute lymphoblastic leukemia.,2022,10.1186/s12864-022-08688-1,https://pubmed.ncbi.nlm.nih.gov/35751016/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOT1L1,ENSG00000169154,Neither,25287256,Is D-aspartate produced by glutamic-oxaloacetic transaminase-1 like 1 (Got1l1): a putative aspartate racemase?,2015,10.1007/s00726-014-1847-3,https://pubmed.ncbi.nlm.nih.gov/25287256/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOT1L1,ENSG00000169154,Neither,25646960,Biosynthesis of D-aspartate in mammals: the rat and human homologs of mouse aspartate racemase are not responsible for the biosynthesis of D-aspartate.,2015,10.1007/s00726-015-1926-0,https://pubmed.ncbi.nlm.nih.gov/25646960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,41632528,Reduced glycoprotein hormone β5 links male aging and testosterone decline to increased adiposity.,2026,10.1172/jci192355,https://pubmed.ncbi.nlm.nih.gov/41632528/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,41373675,Molecular and Functional Insights into Thyrostimulin and Its Subunits-GPA2/GPB5.,2025,10.3390/ijms262311523,https://pubmed.ncbi.nlm.nih.gov/41373675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,41724374,First insight into the regulatory role of the glycoprotein hormones GPA2 and GPB5 in the small-spotted catshark (Scyliorhinus canicula L.) during spermiogenesis.,2026,10.1016/j.jprot.2026.105627,https://pubmed.ncbi.nlm.nih.gov/41724374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,40254178,"Pleiotropic signaling of single-chain thyrostimulin (GPB5-GPA2) on homologous glycoprotein hormone receptors (ScFSHR, ScLHR, ScTSHR) in the elasmobranch Scyliorhinus canicula reproduction.",2025,10.1016/j.mce.2025.112553,https://pubmed.ncbi.nlm.nih.gov/40254178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,42609294,Expression and RNAi characterization of neuropeptides underlying developmental regulation in the Colorado potato beetle.,2026,10.3389/finsc.2026.1862257,https://pubmed.ncbi.nlm.nih.gov/42609294/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,41052974,Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants.,2025,10.1038/s41398-025-03578-y,https://pubmed.ncbi.nlm.nih.gov/41052974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,39475106,The glycoprotein hormone receptor (LGR1) influences Malpighian tubule secretion rate in Rhodnius prolixus.,2024,10.1242/jeb.249357,https://pubmed.ncbi.nlm.nih.gov/39475106/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,36568071,Elevated circulating GPHB5 levels in women with insulin resistance and polycystic ovary syndrome: A cross-sectional study and multiple intervention studies.,2022,10.3389/fendo.2022.1010714,https://pubmed.ncbi.nlm.nih.gov/36568071/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,35757403,GPHB5 Is a Biomarker in Women With Metabolic Syndrome: Results From Cross-Sectional and Intervention Studies.,2022,10.3389/fendo.2022.893142,https://pubmed.ncbi.nlm.nih.gov/35757403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,42157480,A Glycoprotein Hormone Orchestrates Ovarian Development in the Fall Armyworm &lt;i&gt;Spodoptera Frugiperda&lt;/i&gt;.,2026,10.1021/acs.jafc.5c14888,https://pubmed.ncbi.nlm.nih.gov/42157480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,40131296,The Spatial Transcriptomic Atlas of Human Limbus and Vital Niche Microenvironment Regulating the Fate of Limbal Epithelial Stem Cells.,2025,10.1167/iovs.66.3.52,https://pubmed.ncbi.nlm.nih.gov/40131296/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,41015077,"Reproductive gene expression in female broodstock European flat oyster, Ostrea edulis, under ambient and constant temperature and photoperiod regimes.",2025,10.1016/j.cbpa.2025.111934,https://pubmed.ncbi.nlm.nih.gov/41015077/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,37409228,Ancestral glycoprotein hormone-receptor pathway controls growth in C. elegans.,2023,10.3389/fendo.2023.1200407,https://pubmed.ncbi.nlm.nih.gov/37409228/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,38468806,Investigating the role of glycoprotein hormone GPA2/GPB5 signaling in reproduction in adult female Rhodnius prolixus.,2022,10.3389/finsc.2022.1096089,https://pubmed.ncbi.nlm.nih.gov/38468806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,42305012,De Novo Genome Assemblies of Four Rainbow Trout Genetic Lines Reveal Structural Variants in Pursuit of a Pangenome Reference.,2026,10.1111/1755-0998.70167,https://pubmed.ncbi.nlm.nih.gov/42305012/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,41750351,Genome-Wide Association Study of Gross Hair Weight and Hair Length Traits in Different Body Regions of Tianzhu White Yak.,2026,10.3390/biom16020282,https://pubmed.ncbi.nlm.nih.gov/41750351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,39561202,Cell non-autonomous signaling through the conserved C. elegans glycoprotein hormone receptor FSHR-1 regulates cholinergic neurotransmission.,2024,10.1371/journal.pgen.1011461,https://pubmed.ncbi.nlm.nih.gov/39561202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,39260593,"RhoprCAPA-2 acts as a gonadotropin regulating reproduction in adult female, Rhodnius prolixus.",2024,10.1016/j.ygcen.2024.114611,https://pubmed.ncbi.nlm.nih.gov/39260593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,37842303,"Corticotropin-releasing factor-like diuretic hormone acts as a gonad-inhibiting hormone in adult female, Rhodnius prolixus.",2023,10.3389/fendo.2023.1279929,https://pubmed.ncbi.nlm.nih.gov/37842303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,36592853,Ancestral glycoprotein hormone and its cognate receptor present in primitive chordate ascidian: Molecular identification and functional characterization.,2023,10.1016/j.ijbiomac.2022.12.297,https://pubmed.ncbi.nlm.nih.gov/36592853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,34671318,Unconventional Actions of Glycoprotein Hormone Subunits: A Comprehensive Review.,2021,10.3389/fendo.2021.731966,https://pubmed.ncbi.nlm.nih.gov/34671318/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,32296389,"Expression Profiling, Downstream Signaling, and Inter-subunit Interactions of GPA2/GPB5 in the Adult Mosquito Aedes aegypti.",2020,10.3389/fendo.2020.00158,https://pubmed.ncbi.nlm.nih.gov/32296389/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,15699348,Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5.,2005,10.1073/pnas.0409849102,https://pubmed.ncbi.nlm.nih.gov/15699348/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,16210345,A glycoprotein hormone expressed in corticotrophs exhibits unique binding properties on thyroid-stimulating hormone receptor.,2006,10.1210/me.2005-0270,https://pubmed.ncbi.nlm.nih.gov/16210345/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPHB5,ENSG00000179600,Neither,12089349,"Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5.",2002,10.1210/mend.16.7.0871,https://pubmed.ncbi.nlm.nih.gov/12089349/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,42321470,Tryptamine from wake-active monoaminergic neurons regulates sleep homeostasis.,2026,10.1038/s41593-026-02332-x,https://pubmed.ncbi.nlm.nih.gov/42321470/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,42619573,Systematic profiling reveals broad G protein coupling and context-dependent modulation of cyclic AMP by the orphan receptor GPR139.,2026,10.1111/bph.70606,https://pubmed.ncbi.nlm.nih.gov/42619573/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,41365886,Ultra-large virtual screening unveils potent agonists of the neuromodulatory orphan receptor GPR139.,2025,10.1038/s41467-025-66845-y,https://pubmed.ncbi.nlm.nih.gov/41365886/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,41915403,"Expression Analysis of the orphan receptors GPR161, GPR132, GPR20, and GPR139 in patients with cervicitis and low-grade, and high-grade squamous intraepithelial lesions.",2026,10.1590/1678-4685-gmb-2025-0191,https://pubmed.ncbi.nlm.nih.gov/41915403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,42217817,Targeting Mu Opioid Receptor Neurons of the Habenula to Limit Naloxone Aversion.,2026,10.1016/j.biopsych.2026.05.014,https://pubmed.ncbi.nlm.nih.gov/42217817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,40102345,"GPR139, an Ancient Receptor and an Emerging Target for Neuropsychiatric and Behavioral Disorders.",2025,10.1007/s12035-025-04828-2,https://pubmed.ncbi.nlm.nih.gov/40102345/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,39717703,GPR139 agonist and antagonist differentially regulate retrieval and consolidation of fear memory in the zebrafish.,2024,10.3389/fnins.2024.1461148,https://pubmed.ncbi.nlm.nih.gov/39717703/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,40402163,Surrogate GPR139 Agonists Reverse Short-Term Startle Habituation Impairment in Larval Zebrafish.,2025,10.1096/fj.202500594r,https://pubmed.ncbi.nlm.nih.gov/40402163/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,40701991,Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor.,2025,10.1038/s41467-025-62133-x,https://pubmed.ncbi.nlm.nih.gov/40701991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,41365196,Yangxue Qingnao Wan ameliorates cognitive impairment in scopolamine-induced AD mice via modulating neuropeptide signaling pathways and suppressing neuroinflammation.,2026,10.1016/j.phymed.2025.157602,https://pubmed.ncbi.nlm.nih.gov/41365196/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,40719142,A Phase 2 Randomized Trial of NBI-1065846 (TAK-041) in Patients With Anhedonia Associated With Major Depressive Disorder: Results of the TERPSIS Study.,2025,10.1097/jcp.0000000000002046,https://pubmed.ncbi.nlm.nih.gov/40719142/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,38447415,Up-regulation of GPR139 in the medial septum ameliorates cognitive impairment in two mouse models of Alzheimer's disease.,2024,10.1016/j.intimp.2024.111786,https://pubmed.ncbi.nlm.nih.gov/38447415/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,40817174,The GPR139 agonist TAK-041 produces time-dependent alterations to cerebral blood flow and reward system function in patients with schizophrenia: a randomised placebo-controlled trial.,2026,10.1007/s00213-025-06884-x,https://pubmed.ncbi.nlm.nih.gov/40817174/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,38059447,Research progress on the role of orphan receptor GPR139 in neuropsychiatric behaviours.,2023,10.1016/j.ejphar.2023.176150,https://pubmed.ncbi.nlm.nih.gov/38059447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,42173424,Precision pharmacology of CNS GPCRs: From biased signaling to translational therapeutics.,2026,10.1016/j.pnpbp.2026.111752,https://pubmed.ncbi.nlm.nih.gov/42173424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,36347339,"The orphan G protein-coupled receptor, GPR139, is expressed in the hypothalamus and is involved in the regulation of body mass, blood glucose, and insulin.",2023,10.1016/j.neulet.2022.136955,https://pubmed.ncbi.nlm.nih.gov/36347339/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,38073127,Orphan peptide and G protein-coupled receptor signalling in alcohol use disorder.,2024,10.1111/bph.16301,https://pubmed.ncbi.nlm.nih.gov/38073127/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,34675381,Endogenous dopamine release in the human brain as a pharmacodynamic biomarker: evaluation of the new GPR139 agonist TAK-041 with [11C]PHNO PET.,2022,10.1038/s41386-021-01204-1,https://pubmed.ncbi.nlm.nih.gov/34675381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,35561791,Effects of GPR139 agonism on effort expenditure for food reward in rodent models: Evidence for pro-motivational actions.,2022,10.1016/j.neuropharm.2022.109078,https://pubmed.ncbi.nlm.nih.gov/35561791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,37835726,"The Expression of Amino Acid and Fatty Acid Receptors Show an Age-Dependent Pattern Involving Oral Cavity, Jejunum and Lower Gut Sensing in Broiler Chickens.",2023,10.3390/ani13193120,https://pubmed.ncbi.nlm.nih.gov/37835726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,34916631,Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139.,2022,10.1038/s41422-021-00591-w,https://pubmed.ncbi.nlm.nih.gov/34916631/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,33479510,The role of orphan receptor GPR139 in neuropsychiatric behavior.,2022,10.1038/s41386-021-00962-2,https://pubmed.ncbi.nlm.nih.gov/33479510/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,33679382,Pan-Cancer Analysis and Drug Formulation for GPR139 and GPR142.,2020,10.3389/fphar.2020.521245,https://pubmed.ncbi.nlm.nih.gov/33679382/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,31416932,Genetic behavioral screen identifies an orphan anti-opioid system.,2019,10.1126/science.aau2078,https://pubmed.ncbi.nlm.nih.gov/31416932/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,30949055,"In vivo Characterization of a Selective, Orally Available, and Brain Penetrant Small Molecule GPR139 Agonist.",2019,10.3389/fphar.2019.00273,https://pubmed.ncbi.nlm.nih.gov/30949055/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,30971885,GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact.,2019,10.3389/fnins.2019.00281,https://pubmed.ncbi.nlm.nih.gov/30971885/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,35990593,Habenula bibliometrics: Thematic development and research fronts of a resurgent field.,2022,10.3389/fnint.2022.949162,https://pubmed.ncbi.nlm.nih.gov/35990593/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,33344888,Translation-Focused Approaches to GPCR Drug Discovery for Cognitive Impairments Associated with Schizophrenia.,2020,10.1021/acsptsci.0c00117,https://pubmed.ncbi.nlm.nih.gov/33344888/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,35277995,"A phase 1 study to evaluate the safety, tolerability and pharmacokinetics of TAK-041 in healthy participants and patients with stable schizophrenia.",2022,10.1111/bcp.15305,https://pubmed.ncbi.nlm.nih.gov/35277995/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,36271074,Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment.,2022,10.1038/s41467-022-34011-3,https://pubmed.ncbi.nlm.nih.gov/36271074/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,27445691,Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP(+) and Rotenone Toxicity.,2016,10.3389/fncel.2016.00164,https://pubmed.ncbi.nlm.nih.gov/27445691/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,29971251,Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats.,2018,10.1523/eneuro.0153-18.2018,https://pubmed.ncbi.nlm.nih.gov/29971251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,35383335,Genetic variants associated with longitudinal changes in brain structure across the lifespan.,2022,10.1038/s41593-022-01042-4,https://pubmed.ncbi.nlm.nih.gov/35383335/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR139,ENSG00000180269,Neither,15845401,Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system.,2005,10.1016/j.bbrc.2005.03.174,https://pubmed.ncbi.nlm.nih.gov/15845401/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,40764335,P-Rex2 suppresses glucose uptake into liver and skeletal muscle through different adaptor functions.,2025,10.1038/s41598-025-01720-w,https://pubmed.ncbi.nlm.nih.gov/40764335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,42269381,International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors.,2026,10.1016/j.pharmr.2026.100141,https://pubmed.ncbi.nlm.nih.gov/42269381/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,36721851,Cryo-EM structure of orphan G protein-coupled receptor GPR21.,2023,10.1002/mco2.205,https://pubmed.ncbi.nlm.nih.gov/36721851/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,36362842,"Glycine Effect on the Expression Profile of Orphan Receptors GPR21, GPR26, GPR39, GPR82 and GPR6 in a Model of Inflammation in 3T3-L1 Cells.",2022,10.3390/life12111687,https://pubmed.ncbi.nlm.nih.gov/36362842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,34782333,Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms.,2021,10.1136/bmjdrc-2021-002285,https://pubmed.ncbi.nlm.nih.gov/34782333/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,36639690,Cryo-EM structures of orphan GPR21 signaling complexes.,2023,10.1038/s41467-023-35882-w,https://pubmed.ncbi.nlm.nih.gov/36639690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,34639123,GPR21 Inhibition Increases Glucose-Uptake in HepG2 Cells.,2021,10.3390/ijms221910784,https://pubmed.ncbi.nlm.nih.gov/34639123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,35021931,"Expression profiles of GPR21, GPR39, GPR135, and GPR153 orphan receptors in different cancers.",2022,10.1080/15257770.2021.2002892,https://pubmed.ncbi.nlm.nih.gov/35021931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,35537492,G protein-coupled receptor 21 in macrophages: An in vitro study.,2022,10.1016/j.ejphar.2022.175018,https://pubmed.ncbi.nlm.nih.gov/35537492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,32583711,Modifications in GPR21 and GPR82 genes expression as a consequence of metabolic syndrome etiology.,2021,10.1080/10799893.2020.1784228,https://pubmed.ncbi.nlm.nih.gov/32583711/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,27081476,GPR21 KO mice demonstrate no resistance to high fat diet induced obesity or improved glucose tolerance.,2016,10.12688/f1000research.7822.2,https://pubmed.ncbi.nlm.nih.gov/27081476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,27243589,"Regulating the effects of GPR21, a novel target for type 2 diabetes.",2016,10.1038/srep27002,https://pubmed.ncbi.nlm.nih.gov/27243589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,34868210,Whole-Genome Selective Scans Detect Genes Associated With Important Phenotypic Traits in Sheep (Ovis aries).,2021,10.3389/fgene.2021.738879,https://pubmed.ncbi.nlm.nih.gov/34868210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,22653059,G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice.,2012,10.1172/jci61953,https://pubmed.ncbi.nlm.nih.gov/22653059/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,22155242,G-protein-coupled receptor GPR21 knockout mice display improved glucose tolerance and increased insulin response.,2012,10.1016/j.bbrc.2011.11.117,https://pubmed.ncbi.nlm.nih.gov/22155242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,26934370,Neuronal Orphan G-Protein Coupled Receptor Proteins Mediate Plasmalogens-Induced Activation of ERK and Akt Signaling.,2016,10.1371/journal.pone.0150846,https://pubmed.ncbi.nlm.nih.gov/26934370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,26384023,Constitutive Activity among Orphan Class-A G Protein Coupled Receptors.,2015,10.1371/journal.pone.0138463,https://pubmed.ncbi.nlm.nih.gov/26384023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,9073069,Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes.,1997,10.1016/s0378-1119(96)00722-6,https://pubmed.ncbi.nlm.nih.gov/9073069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,9931487,"Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain.",1999,10.1016/s0169-328x(98)00277-0,https://pubmed.ncbi.nlm.nih.gov/9931487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR21,ENSG00000188394,Neither,15090189,Identification of signal transduction pathways used by orphan g protein-coupled receptors.,2003,10.1089/15406580360545053,https://pubmed.ncbi.nlm.nih.gov/15090189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,41081084,The 12-LOX/12-HETE/GPR31 metabolic pathway promotes tumor-associated macrophage M2 polarization mediated pancreatic cancer development.,2025,10.7717/peerj.19963,https://pubmed.ncbi.nlm.nih.gov/41081084/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,41372218,Pla2g7 regulates bone homeostasis via Alox12/12-HETE/Gpr31 signaling axis.,2025,10.1038/s41467-025-66285-8,https://pubmed.ncbi.nlm.nih.gov/41372218/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,40892510,Integrated screening identifies GPR31 as a key driver and druggable target for metabolic dysfunction-associated steatohepatitis.,2025,10.1172/jci173193,https://pubmed.ncbi.nlm.nih.gov/40892510/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,40745869,Pyruvate-GPR31 axis induces LysoDC dendrite protrusion to M-cell pockets for effective immune responses.,2025,10.1080/19490976.2025.2536089,https://pubmed.ncbi.nlm.nih.gov/40745869/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,42269381,International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors.,2026,10.1016/j.pharmr.2026.100141,https://pubmed.ncbi.nlm.nih.gov/42269381/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,41061481,B7-H3-mediated reversal of CAR-T cell exhaustion induces a notable antitumour response in ovarian cancer models.,2025,10.1016/j.ebiom.2025.105949,https://pubmed.ncbi.nlm.nih.gov/41061481/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,39432783,The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells.,2024,10.1073/pnas.2318767121,https://pubmed.ncbi.nlm.nih.gov/39432783/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,38141777,12-HETE activates Müller glial cells: The potential role of GPR31 and miR-29.,2024,10.1016/j.prostaglandins.2023.106805,https://pubmed.ncbi.nlm.nih.gov/38141777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,38278551,12-(S)-Hydroxyeicosatetraenoic Acid and GPR31 Signaling in Spinal Cord in Neuropathic Pain.,2024,10.1124/jpet.123.001853,https://pubmed.ncbi.nlm.nih.gov/38278551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,39295162,12-HETE/GPR31 induces endothelial dysfunction in diabetic retinopathy.,2024,10.1096/fj.202401362r,https://pubmed.ncbi.nlm.nih.gov/39295162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,35011589,"Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in Common Skin Tumors.",2021,10.3390/cells11010027,https://pubmed.ncbi.nlm.nih.gov/35011589/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,41909960,Genetic Parameters and Genome-Wide Association Studies for Fertility and Reproduction Traits in U.S. Katahdin Sheep Based on the Single-Step GBLUP Methodology.,2026,10.1111/jbg.70048,https://pubmed.ncbi.nlm.nih.gov/41909960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,38906238,Role of orphan G-protein coupled receptors in tissue ischemia: A comprehensive review.,2024,10.1016/j.ejphar.2024.176762,https://pubmed.ncbi.nlm.nih.gov/38906238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,39959641,Inflammatory Gene Signature Identified by Machine Algorithms Reveals Novel Biomarkers of Coronary Artery Disease.,2025,10.2147/jir.s496046,https://pubmed.ncbi.nlm.nih.gov/39959641/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,32918516,A 12-lipoxygenase-Gpr31 signaling axis is required for pancreatic organogenesis in the zebrafish.,2020,10.1096/fj.201902308rr,https://pubmed.ncbi.nlm.nih.gov/32918516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,35315361,Modulation of gentamicin-induced acute kidney injury by myo-inositol oxygenase via the ROS/ALOX-12/12-HETE/GPR31 signaling pathway.,2022,10.1172/jci.insight.155487,https://pubmed.ncbi.nlm.nih.gov/35315361/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,33972436,Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation.,2021,10.1073/pnas.2023871118,https://pubmed.ncbi.nlm.nih.gov/33972436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,33267659,Lipid Receptor GPR31 (G-Protein-Coupled Receptor 31) Regulates Platelet Reactivity and Thrombosis Without Affecting Hemostasis.,2021,10.1161/atvbaha.120.315154,https://pubmed.ncbi.nlm.nih.gov/33267659/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,38999982,G Protein-Coupled Receptor-Ligand Pose and Functional Class Prediction.,2024,10.3390/ijms25136876,https://pubmed.ncbi.nlm.nih.gov/38999982/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,30416315,Overexpression of G protein-coupled receptor 31 as a poor prognosticator in human colorectal cancer.,2018,10.3748/wjg.v24.i41.4679,https://pubmed.ncbi.nlm.nih.gov/30416315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,41777183,The potential of GPR31 as a target for effective oral vaccination.,2026,10.1080/14728222.2026.2641654,https://pubmed.ncbi.nlm.nih.gov/41777183/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR31,ENSG00000120436,Neither,36188607,Typing characteristics of metabolism-related genes in osteoporosis.,2022,10.3389/fphar.2022.999157,https://pubmed.ncbi.nlm.nih.gov/36188607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,42384133,GPx6 downregulation drives ferroptosis in Kashin-Beck disease chondrocytes via the SLC7A11/GPx4 axis.,2026,10.1007/s10495-026-02389-w,https://pubmed.ncbi.nlm.nih.gov/42384133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,42664731,"Genome-wide identification, characterization, and expression analysis of the glutathione peroxidase (GPX) gene family in Siniperca chuatsi.",2026,10.1016/j.cbd.2026.101981,https://pubmed.ncbi.nlm.nih.gov/42664731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,41876995,Tracing the vertebrate selenoproteome evolution reveals expansions in ray-finned fishes and convergent depletions in tetrapods.,2026,10.1186/s12864-026-12780-1,https://pubmed.ncbi.nlm.nih.gov/41876995/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,41718785,Expression patterns of glutathione peroxidases family members during tooth development.,2026,10.1007/s10735-026-10748-9,https://pubmed.ncbi.nlm.nih.gov/41718785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,37761814,Glutathione Peroxidase gpx1 to gpx8 Genes Expression in Experimental Brain Tumors Reveals Gender-Dependent Patterns.,2023,10.3390/genes14091674,https://pubmed.ncbi.nlm.nih.gov/37761814/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,42660330,Genetic variation in oxidative stress and detoxification pathways associated with prostate cancer susceptibility: a pathway-based analysis.,2026,10.1016/j.freeradbiomed.2026.08.048,https://pubmed.ncbi.nlm.nih.gov/42660330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,40367564,Selenoprotein S ablation-mediated pyroptosis contributes to liver damage resulting from selenium deficiency in chickens.,2025,10.1016/j.psj.2025.105269,https://pubmed.ncbi.nlm.nih.gov/40367564/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,39971753,Epigenome-wide association study of incident type 2 diabetes in Black and White participants from the Atherosclerosis Risk in Communities Study.,2025,10.1007/s00125-024-06352-9,https://pubmed.ncbi.nlm.nih.gov/39971753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,37605246,Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice.,2023,10.1186/s13578-023-01095-3,https://pubmed.ncbi.nlm.nih.gov/37605246/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,40505773,Bioinformatics analysis of hub genes and oxidative stress-related pathways in odontogenic keratocysts.,2025,10.1016/j.jormas.2025.102423,https://pubmed.ncbi.nlm.nih.gov/40505773/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,40427408,Hydroxy-Selenomethionine Supplementation During Gestation and Lactation Improve Reproduction of Sows by Enhancing the Antioxidant Capacity and Immunity Under Heat Stress Conditions.,2025,10.3390/antiox14050525,https://pubmed.ncbi.nlm.nih.gov/40427408/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,36937839,Research progress of glutathione peroxidase family (GPX) in redoxidation.,2023,10.3389/fphar.2023.1147414,https://pubmed.ncbi.nlm.nih.gov/36937839/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,38953254,[Expression Levels and Regulation of Selenoprotein Genes in Patients With Coronavirus Disease 2019].,2024,10.3881/j.issn.1000-503x.15834,https://pubmed.ncbi.nlm.nih.gov/38953254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,38447079,Ancient Loss of Catalytic Selenocysteine Spurred Convergent Adaptation in a Mammalian Oxidoreductase.,2024,10.1093/gbe/evae041,https://pubmed.ncbi.nlm.nih.gov/38447079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,32698036,GPx6 is involved in the in vitro induced capacitation and acrosome reaction in porcine sperm.,2020,10.1016/j.theriogenology.2020.06.020,https://pubmed.ncbi.nlm.nih.gov/32698036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,36636221,Bioinformatics analysis on the expression of GPX family in gastric cancer and its correlation with the prognosis of gastric cancer.,2022,10.1016/j.heliyon.2022.e12214,https://pubmed.ncbi.nlm.nih.gov/36636221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,37286763,Oxidative damage contributes to bisphenol S-induced development block at 2-cell stage preimplantation embryos in mice through inhibiting of embryonic genome activation.,2023,10.1038/s41598-023-36441-5,https://pubmed.ncbi.nlm.nih.gov/37286763/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,39029196,Coordination regulation of enhanced performance reveals the tolerance mechanism of Chlamys farreri to azaspiracid toxicity.,2024,10.1016/j.jhazmat.2024.135247,https://pubmed.ncbi.nlm.nih.gov/39029196/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,35486068,"Retinal Neuroprotective Effect of Mesenchymal Stem Cells Secretome Through Modulation of Oxidative Stress, Autophagy, and Programmed Cell Death.",2022,10.1167/iovs.63.4.27,https://pubmed.ncbi.nlm.nih.gov/35486068/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,37557018,Combined transcriptome and proteome analysis revealed the molecular regulation mechanisms of zinc homeostasis and antioxidant machinery in tobacco in response to different zinc supplies.,2023,10.1016/j.plaphy.2023.107919,https://pubmed.ncbi.nlm.nih.gov/37557018/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,34680111,Impact of Selenium on Biomarkers and Clinical Aspects Related to Ageing. A Review.,2021,10.3390/biom11101478,https://pubmed.ncbi.nlm.nih.gov/34680111/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,37820291,GRAIL gene knockout mice protect against aging-related and noise-induced hearing loss.,2023,10.1097/jcma.0000000000001005,https://pubmed.ncbi.nlm.nih.gov/37820291/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,36138806,Genetic Diversity and Selective Signature in Dabieshan Cattle Revealed by Whole-Genome Resequencing.,2022,10.3390/biology11091327,https://pubmed.ncbi.nlm.nih.gov/36138806/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,37741974,Matched analysis of circulating selenium with the breast cancer selenotranscriptome: a multicentre prospective study.,2023,10.1186/s12967-023-04502-y,https://pubmed.ncbi.nlm.nih.gov/37741974/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,25535386,Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington's disease.,2015,10.1073/pnas.1417231112,https://pubmed.ncbi.nlm.nih.gov/25535386/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,34381803,"Effects of Selenomethionine on Cell Viability, Selenoprotein Expression and Antioxidant Function in Porcine Mammary Epithelial Cells.",2021,10.3389/fnut.2021.665855,https://pubmed.ncbi.nlm.nih.gov/34381803/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,31398888,Assessment of Drugs Toxicity and Associated Biomarker Genes Using Hierarchical Clustering.,2019,10.3390/medicina55080451,https://pubmed.ncbi.nlm.nih.gov/31398888/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,33014046,Vitamins Modulate the Expression of Antioxidant Genes in Progesterone-Treated Pancreatic β Cells: Perspectives for Gestational Diabetes Management.,2020,10.1155/2020/8745120,https://pubmed.ncbi.nlm.nih.gov/33014046/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,27957666,Decreased Expression of Selenoproteins as a Poor Prognosticator of Gastric Cancer in Humans.,2017,10.1007/s12011-016-0908-8,https://pubmed.ncbi.nlm.nih.gov/27957666/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,26147969,Alkbh8 Regulates Selenocysteine-Protein Expression to Protect against Reactive Oxygen Species Damage.,2015,10.1371/journal.pone.0131335,https://pubmed.ncbi.nlm.nih.gov/26147969/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPX6,ENSG00000198704,Neither,12775843,Characterization of mammalian selenoproteomes.,2003,10.1126/science.1083516,https://pubmed.ncbi.nlm.nih.gov/12775843/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,38819436,Genetically defined nucleus incertus neurons differ in connectivity and function.,2024,10.7554/elife.89516,https://pubmed.ncbi.nlm.nih.gov/38819436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,41760201,[A group-level stimulus-aware self-supervised soft contrastive learning framework for electroencephalogram emotion recognition].,2026,10.7507/1001-5515.202504004,https://pubmed.ncbi.nlm.nih.gov/41760201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,37375432,Integrated Transcriptomic and Metabolomic Analyses Reveal the Effects of Grafting on Special Metabolites of Acanthopanax senticosus Leaves.,2023,10.3390/molecules28124877,https://pubmed.ncbi.nlm.nih.gov/37375432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,37964983,A Novel Molecular Classification Method for Glioblastoma Based on Tumor Cell Differentiation Trajectories.,2023,10.1155/2023/2826815,https://pubmed.ncbi.nlm.nih.gov/37964983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,38786702,Sequential Induction of Drug Resistance and Characterization of an Initial Candida albicans Drug-Sensitive Isolate.,2024,10.3390/jof10050347,https://pubmed.ncbi.nlm.nih.gov/38786702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,20921407,Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep.,2010,10.1073/pnas.1012764107,https://pubmed.ncbi.nlm.nih.gov/20921407/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,9811926,Functional analysis of Gscl in the pathogenesis of the DiGeorge and velocardiofacial syndromes.,1998,10.1093/hmg/7.12.1835,https://pubmed.ncbi.nlm.nih.gov/9811926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,9811927,"Goosecoid-like (Gscl), a candidate gene for velocardiofacial syndrome, is not essential for normal mouse development.",1998,10.1093/hmg/7.12.1841,https://pubmed.ncbi.nlm.nih.gov/9811927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,9150167,The DiGeorge syndrome minimal critical region contains a goosecoid-like (GSCL) homeobox gene that is expressed early in human development.,1997,,https://pubmed.ncbi.nlm.nih.gov/9150167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,16900388,Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndrome.,2006,10.1007/s10048-006-0054-0,https://pubmed.ncbi.nlm.nih.gov/16900388/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,10822263,"Rnf4, a RING protein expressed in the developing nervous and reproductive systems, interacts with Gscl, a gene within the DiGeorge critical region.",2000,10.1002/(sici)1097-0177(200005)218:1<102::aid-dvdy9>3.0.co;2-a,https://pubmed.ncbi.nlm.nih.gov/10822263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,9700206,"Goosecoid-like, a gene deleted in DiGeorge and velocardiofacial syndromes, recognizes DNA with a bicoid-like specificity and is expressed in the developing mouse brain.",1998,10.1093/hmg/7.9.1497,https://pubmed.ncbi.nlm.nih.gov/9700206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,22745270,Arsenic stress elicits cytosolic Ca(2+) bursts and Crz1 activation in Saccharomyces cerevisiae.,2012,10.1099/mic.0.059170-0,https://pubmed.ncbi.nlm.nih.gov/22745270/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,9603426,"Gscl, a gene within the minimal DiGeorge critical region, is expressed in primordial germ cells and the developing pons.",1998,10.1002/(sici)1097-0177(199805)212:1<86::aid-aja8>3.0.co;2-z,https://pubmed.ncbi.nlm.nih.gov/9603426/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,16116083,"The Smk1p MAP kinase negatively regulates Gsc2p, a 1,3-beta-glucan synthase, during spore wall morphogenesis in Saccharomyces cerevisiae.",2005,10.1073/pnas.0502324102,https://pubmed.ncbi.nlm.nih.gov/16116083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,9441739,"Characterization and mutation analysis of goosecoid-like (GSCL), a homeodomain-containing gene that maps to the critical region for VCFS/DGS on 22q11.",1997,10.1006/geno.1997.5046,https://pubmed.ncbi.nlm.nih.gov/9441739/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,18396099,Subjective complaints in persons under chronic low-dose exposure to lower polychlorinated biphenyls (PCBs).,2008,10.1016/j.ijheh.2008.02.001,https://pubmed.ncbi.nlm.nih.gov/18396099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,16197812,Chromosomal and genetic abnormalities in benign and malignant meningiomas using DNA microarray.,2005,10.1179/016164105x35648,https://pubmed.ncbi.nlm.nih.gov/16197812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,15755916,Saccharomyces cerevisiae Sps1p regulates trafficking of enzymes required for spore wall synthesis.,2005,10.1128/ec.4.3.536-544.2005,https://pubmed.ncbi.nlm.nih.gov/15755916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,9499415,"ES2, a gene deleted in DiGeorge syndrome, encodes a nuclear protein and is expressed during early mouse development, where it shares an expression domain with a Goosecoid-like gene.",1998,10.1093/hmg/7.4.629,https://pubmed.ncbi.nlm.nih.gov/9499415/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,30648197,Changes in oral health-related quality of life after three different strategies of implant therapy: a clinical trial.,2019,10.1007/s10266-018-0406-x,https://pubmed.ncbi.nlm.nih.gov/30648197/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSC2,ENSG00000063515,Neither,9718242,Prevention of disturbed eating behaviour: a prospective intervention study in 14- to 19-year-old Swiss students.,1998,10.1111/j.1600-0447.1998.tb10057.x,https://pubmed.ncbi.nlm.nih.gov/9718242/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTT4,ENSG00000276950,Neither,41676086,Clinical exome sequencing identifies novel gene variants associated with ischemic stroke in the Saudi Tabuk population.,2025,10.3389/fnhum.2025.1645598,https://pubmed.ncbi.nlm.nih.gov/41676086/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTT4,ENSG00000276950,Neither,42602198,Genetic sequencing of children with malrotation and midgut volvulus: A cross-sectional study.,2026,10.1002/jpr3.70230,https://pubmed.ncbi.nlm.nih.gov/42602198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTT4,ENSG00000276950,Neither,41466042,New candidate gene mutations in astrocytoma with seizures.,2025,10.1038/s41598-025-34357-w,https://pubmed.ncbi.nlm.nih.gov/41466042/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTT4,ENSG00000276950,Neither,42641857,Polypropylene microplastics orchestrate oxidative stress microenvironment and trigger metabolic reprogramming in mouse kidney as revealed by Raman spectra and metabolomics.,2026,10.1016/j.envpol.2026.129000,https://pubmed.ncbi.nlm.nih.gov/42641857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTT4,ENSG00000276950,Neither,39181079,Gut dysbiosis of Rana zhenhaiensis tadpoles after lead (Pb) exposure based on integrated analysis of microbiota and gut transcriptome.,2024,10.1016/j.ecoenv.2024.116922,https://pubmed.ncbi.nlm.nih.gov/39181079/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTT4,ENSG00000276950,Neither,34404356,Dysregulated long noncoding RNAs in the brainstem of the DBA/1 mouse model of SUDEP.,2021,10.1186/s12864-021-07921-7,https://pubmed.ncbi.nlm.nih.gov/34404356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTT4,ENSG00000276950,Neither,32027883,Systematic characterization of glutathione S-transferases in common marmosets.,2020,10.1016/j.bcp.2020.113835,https://pubmed.ncbi.nlm.nih.gov/32027883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTT4,ENSG00000276950,Neither,29465581,Atypical microdeletion in 22q11 deletion syndrome reveals new candidate causative genes: A case report and literature review.,2018,10.1097/md.0000000000009936,https://pubmed.ncbi.nlm.nih.gov/29465581/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTT4,ENSG00000276950,Neither,24194744,"Association of maternal CNVs in GSTT1/GSTT2 with smoking, preterm delivery, and low birth weight.",2013,10.3389/fgene.2013.00196,https://pubmed.ncbi.nlm.nih.gov/24194744/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTT4,ENSG00000276950,Neither,27214158,Analysis of gene expression for microminipig liver transcriptomes using parallel long-read technology and short-read sequencing.,2016,10.1002/bdd.2007,https://pubmed.ncbi.nlm.nih.gov/27214158/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTT4,ENSG00000276950,Neither,10334644,Genetic polymorphism of glutathione S-transferase P1 gene and lung cancer risk.,1999,10.1023/a:1008811824890,https://pubmed.ncbi.nlm.nih.gov/10334644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1L,ENSG00000124196,Neither,41784387,Positive Selection Targeted Primate Genes that Encode Transposable Element Repressors.,2026,10.1093/gbe/evag059,https://pubmed.ncbi.nlm.nih.gov/41784387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1L,ENSG00000124196,Neither,37891374,Identification of hub genes associated with spermatogenesis by bioinformatics analysis.,2023,10.1038/s41598-023-45620-3,https://pubmed.ncbi.nlm.nih.gov/37891374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1L,ENSG00000124196,Neither,39951048,Comparative gene expression profiling of fertility related transcripts in bull sperm of different genetic backgrounds.,2025,10.1007/s11250-025-04310-0,https://pubmed.ncbi.nlm.nih.gov/39951048/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1L,ENSG00000124196,Neither,40077805,Depletion of Gtsf1L impairs development of eupyrene sperm and ovary in Bombyx mori.,2025,10.1111/imb.12988,https://pubmed.ncbi.nlm.nih.gov/40077805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1L,ENSG00000124196,Neither,36319089,The two Gtsf paralogs in silkworms orthogonally activate their partner PIWI proteins for target cleavage.,2022,10.1261/rna.079380.122,https://pubmed.ncbi.nlm.nih.gov/36319089/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1L,ENSG00000124196,Neither,37984437,An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori.,2023,10.15252/embj.2023114072,https://pubmed.ncbi.nlm.nih.gov/37984437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1L,ENSG00000124196,Neither,34539641,Development of a Novel Immune Infiltration-Based Gene Signature to Predict Prognosis and Immunotherapy Response of Patients With Cervical Cancer.,2021,10.3389/fimmu.2021.709493,https://pubmed.ncbi.nlm.nih.gov/34539641/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1L,ENSG00000124196,Neither,26930067,Gtsf1l and Gtsf2 Are Specifically Expressed in Gonocytes and Spermatids but Are Not Essential for Spermatogenesis.,2016,10.1371/journal.pone.0150390,https://pubmed.ncbi.nlm.nih.gov/26930067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1L,ENSG00000124196,Neither,24012201,Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis.,2013,10.1016/j.fertnstert.2013.07.1999,https://pubmed.ncbi.nlm.nih.gov/24012201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,40806567,Resveratrol Impairs Insulin Signaling in Hepatic Cells via Activation of PKC and PTP1B Pathways.,2025,10.3390/ijms26157434,https://pubmed.ncbi.nlm.nih.gov/40806567/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,40357364,Shared genetic features inference among hypoxia-ischemia diseases in the presence of heterogenous omics data based on a novel risk assessment method.,2025,10.3389/fgene.2025.1587854,https://pubmed.ncbi.nlm.nih.gov/40357364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,40616194,DNA methylation and hydroxymethylation combined with transcriptional profiling identify key regulators of hyperoxia-induced bronchopulmonary dysplasia.,2025,10.1186/s13148-025-01926-9,https://pubmed.ncbi.nlm.nih.gov/40616194/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,35914715,Comparative proteomics analysis of human FFPE testicular tissues reveals new candidate biomarkers for distinction among azoospermia types and subtypes.,2022,10.1016/j.jprot.2022.104686,https://pubmed.ncbi.nlm.nih.gov/35914715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,37784026,Functional analysis of tumor-derived immunoglobulin lambda and its interacting proteins in cervical cancer.,2023,10.1186/s12885-023-11426-9,https://pubmed.ncbi.nlm.nih.gov/37784026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,32019204,AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.,2020,10.3390/molecules25030609,https://pubmed.ncbi.nlm.nih.gov/32019204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,33514822,"Signalling pathways and mechanistic cues highlighted by transcriptomic analysis of primordial, primary, and secondary ovarian follicles in domestic cat.",2021,10.1038/s41598-021-82051-4,https://pubmed.ncbi.nlm.nih.gov/33514822/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,20881315,Poly(ADP-ribose) metabolism is essential for proper nucleoprotein exchange during mouse spermiogenesis.,2011,10.1095/biolreprod.110.087361,https://pubmed.ncbi.nlm.nih.gov/20881315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,34306386,"Effects of epidural anesthesia combined with dexmedetomidine on blood pressure, sedation, analgesia and serum β-endorphin levels in patients with hip fractures.",2021,,https://pubmed.ncbi.nlm.nih.gov/34306386/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,24140495,Dynamic expression of combinatorial replication-dependent histone variant genes during mouse spermatogenesis.,2014,10.1016/j.gep.2013.10.002,https://pubmed.ncbi.nlm.nih.gov/24140495/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,26584007,Proteogenomic Study beyond Chromosome 9: New Insight into Expressed Variant Proteome and Transcriptome in Human Lung Adenocarcinoma Tissues.,2015,10.1021/acs.jproteome.5b00544,https://pubmed.ncbi.nlm.nih.gov/26584007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,17728347,"The first bromodomain of Brdt, a testis-specific member of the BET sub-family of double-bromodomain-containing proteins, is essential for male germ cell differentiation.",2007,10.1242/dev.004481,https://pubmed.ncbi.nlm.nih.gov/17728347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,15051954,Synergistic effects of germ cell expressed genes on male fertility in mice.,2003,10.1159/000076819,https://pubmed.ncbi.nlm.nih.gov/15051954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,20587610,Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection.,2010,10.1093/molehr/gaq047,https://pubmed.ncbi.nlm.nih.gov/20587610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,15346992,[Isolation of endophytic bacteria in potato and test of antagonistic action to bacterial ring rot of potato].,2002,,https://pubmed.ncbi.nlm.nih.gov/15346992/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,1463843,"Nucleosomal structure and histone H1 subfractional composition of pea (Pisum sativum) root nodules, radicles and callus chromatin.",1992,10.1007/bf00028895,https://pubmed.ncbi.nlm.nih.gov/1463843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,200911,Studies on the mechanism of phosphorylation of synthetic polypeptides by a calf thymus cyclic AMP-dependent protein kinase.,1977,10.1073/pnas.74.10.4261,https://pubmed.ncbi.nlm.nih.gov/200911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,35516494,Characterizing the interaction between methyl ferulate and human serum albumin by saturation transfer difference NMR.,2020,10.1039/d0ra05844k,https://pubmed.ncbi.nlm.nih.gov/35516494/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,8175896,Primate testicular histone H1t genes are highly conserved and the human H1t gene is located on chromosome 6.,1994,10.1002/jcb.240540210,https://pubmed.ncbi.nlm.nih.gov/8175896/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-6,ENSG00000187475,Neither,1889752,Structure and expression of the human gene encoding testicular H1 histone (H1t).,1991,10.1016/0378-1119(91)90284-i,https://pubmed.ncbi.nlm.nih.gov/1889752/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AB3,ENSG00000277745,Neither,24584930,"Mammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-κB signaling pathway.",2014,10.1074/jbc.m113.541664,https://pubmed.ncbi.nlm.nih.gov/24584930/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AB3,ENSG00000277745,Neither,15372075,SWI/SNF remodeling and p300-dependent transcription of histone variant H2ABbd nucleosomal arrays.,2004,10.1038/sj.emboj.7600400,https://pubmed.ncbi.nlm.nih.gov/15372075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AB3,ENSG00000277745,Neither,15192699,Histone variant H2ABbd confers lower stability to the nucleosome.,2004,10.1038/sj.embor.7400182,https://pubmed.ncbi.nlm.nih.gov/15192699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AB3,ENSG00000277745,Neither,19606468,Characterisation of histone variant distribution in human embryonic stem cells by transfection of in vitro transcribed mRNA.,2009,10.1002/mrd.21077,https://pubmed.ncbi.nlm.nih.gov/19606468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AB3,ENSG00000277745,Neither,16601700,Nucleolin is a histone chaperone with FACT-like activity and assists remodeling of nucleosomes.,2006,10.1038/sj.emboj.7601046,https://pubmed.ncbi.nlm.nih.gov/16601700/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AB3,ENSG00000277745,Neither,18227505,A phosphorylated subpopulation of the histone variant macroH2A1 is excluded from the inactive X chromosome and enriched during mitosis.,2008,10.1073/pnas.0711632105,https://pubmed.ncbi.nlm.nih.gov/18227505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AB3,ENSG00000277745,Neither,20008104,H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis.,2010,10.1093/nar/gkp1129,https://pubmed.ncbi.nlm.nih.gov/20008104/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,40146916,Single nucleotide polymorphism at 5' UTR of H2BC1 and promoter methylation influence TSH2B expression.,2025,10.1530/rep-24-0382,https://pubmed.ncbi.nlm.nih.gov/40146916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,35840050,Proteomic and genetic dissection of testis-specific histone 2B in infertile men reveals its contribution to meiosis and sperm motility.,2022,10.1016/j.xfss.2022.07.003,https://pubmed.ncbi.nlm.nih.gov/35840050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,40649876,Age-Associated Proteomic Changes in Human Spermatozoa.,2025,10.3390/ijms26136099,https://pubmed.ncbi.nlm.nih.gov/40649876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,39201790,Comprehensive Analysis of Methylome and Transcriptome to Identify Potential Genes Regulating Porcine Testis Development.,2024,10.3390/ijms25169105,https://pubmed.ncbi.nlm.nih.gov/39201790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,34319233,Epi-mutations for spermatogenic defects by maternal exposure to di(2-ethylhexyl) phthalate.,2021,10.7554/elife.70322,https://pubmed.ncbi.nlm.nih.gov/34319233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,35914715,Comparative proteomics analysis of human FFPE testicular tissues reveals new candidate biomarkers for distinction among azoospermia types and subtypes.,2022,10.1016/j.jprot.2022.104686,https://pubmed.ncbi.nlm.nih.gov/35914715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,35356930,Investigation of hub genes involved in Turner syndrome using biological informatics methods.,2022,10.1097/md.0000000000029069,https://pubmed.ncbi.nlm.nih.gov/35356930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,30131691,CDH23 Methylation Status and Presbycusis Risk in Elderly Women.,2018,10.3389/fnagi.2018.00241,https://pubmed.ncbi.nlm.nih.gov/30131691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,24699735,Structure of human nucleosome containing the testis-specific histone variant TSH2B.,2014,10.1107/s2053230x14004695,https://pubmed.ncbi.nlm.nih.gov/24699735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,29205438,Towards the identification of reliable sperm biomarkers for male infertility: A sperm proteomic approach.,2018,10.1111/and.12919,https://pubmed.ncbi.nlm.nih.gov/29205438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,26911428,"The Effects of Chemotherapeutic Agents, Bleomycin, Etoposide, and Cisplatin, on Chromatin Remodeling in Male Rat Germ Cells.",2016,10.1095/biolreprod.115.137802,https://pubmed.ncbi.nlm.nih.gov/26911428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,32040351,Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction.,2020,10.1080/19396368.2019.1678694,https://pubmed.ncbi.nlm.nih.gov/32040351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,31521702,Mechanism of Caulophyllum robustum Maxim against rheumatoid arthritis using LncRNA-mRNA chip analysis.,2020,10.1016/j.gene.2019.144105,https://pubmed.ncbi.nlm.nih.gov/31521702/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,29409138,Treatment of semen samples with α-chymotrypsin alters the expression pattern of sperm functional proteins-a pilot study.,2018,10.1111/andr.12466,https://pubmed.ncbi.nlm.nih.gov/29409138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,17110399,Testis/sperm-specific histone 2B in the sperm of donors and subfertile patients: variability and relation to chromatin packaging.,2007,10.1093/humrep/del439,https://pubmed.ncbi.nlm.nih.gov/17110399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,22402960,"Exposure to bleomycin, etoposide, and cis-platinum alters rat sperm chromatin integrity and sperm head protein profile.",2012,10.1095/biolreprod.111.098616,https://pubmed.ncbi.nlm.nih.gov/22402960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,21249133,Histone variants and their post-translational modifications in primary human fat cells.,2011,10.1371/journal.pone.0015960,https://pubmed.ncbi.nlm.nih.gov/21249133/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,24140495,Dynamic expression of combinatorial replication-dependent histone variant genes during mouse spermatogenesis.,2014,10.1016/j.gep.2013.10.002,https://pubmed.ncbi.nlm.nih.gov/24140495/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,17257526,Characterisation of a human sperm cell subpopulation marked by the presence of the TSH2B histone.,2007,10.1071/rd06099,https://pubmed.ncbi.nlm.nih.gov/17257526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC1,ENSG00000146047,Neither,12213818,Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning and characterization.,2002,10.1074/jbc.m206065200,https://pubmed.ncbi.nlm.nih.gov/12213818/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BW1,ENSG00000123569,Neither,38892236,&lt;i&gt;H2BFWT&lt;/i&gt; Variations in Sperm DNA and Its Correlation to Pregnancy.,2024,10.3390/ijms25116048,https://pubmed.ncbi.nlm.nih.gov/38892236/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BW1,ENSG00000123569,Neither,39329259,Testis-specific H2B.W1 disrupts nucleosome integrity by reducing DNA-histone interactions.,2024,10.1093/nar/gkae825,https://pubmed.ncbi.nlm.nih.gov/39329259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BW1,ENSG00000123569,Neither,39028130,Adverse Effects of Nicotine on Human Sperm Nuclear Proteins.,2025,10.5534/wjmh.240072,https://pubmed.ncbi.nlm.nih.gov/39028130/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BW1,ENSG00000123569,Neither,40178685,Genetic variants associated with idiopathic Parkinson's disease in Latin America: A systematic review.,2025,10.1007/s10048-025-00817-8,https://pubmed.ncbi.nlm.nih.gov/40178685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BW1,ENSG00000123569,Neither,33440036,"Tobacco smoking and its impact on the expression level of sperm nuclear protein genes: H2BFWT, TNP1, TNP2, PRM1 and PRM2.",2021,10.1111/and.13964,https://pubmed.ncbi.nlm.nih.gov/33440036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BW1,ENSG00000123569,Neither,33245240,Primate-specific histone variants.,2021,10.1139/gen-2020-0094,https://pubmed.ncbi.nlm.nih.gov/33245240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BW1,ENSG00000123569,Neither,28370107,Association of the c.-9C>T and c.368A>G transitions in H2BFWT gene with male infertility in an Iranian population.,2018,10.1111/and.12805,https://pubmed.ncbi.nlm.nih.gov/28370107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BW1,ENSG00000123569,Neither,29453813,"Association between two common transitions of H2BFWT gene and male infertility: a case-control, meta, and structural analysis.",2018,10.1111/andr.12464,https://pubmed.ncbi.nlm.nih.gov/29453813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BW1,ENSG00000123569,Neither,32376790,Human X chromosome exome sequencing identifies BCORL1 as contributor to spermatogenesis.,2021,10.1136/jmedgenet-2019-106598,https://pubmed.ncbi.nlm.nih.gov/32376790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BW1,ENSG00000123569,Neither,15475252,Novel human testis-specific histone H2B encoded by the interrupted gene on the X chromosome.,2004,10.1016/j.ygeno.2004.06.001,https://pubmed.ncbi.nlm.nih.gov/15475252/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BW1,ENSG00000123569,Neither,22509975,Relationship of SNP of H2BFWT gene to male infertility in a Chinese population with idiopathic spermatogenesis impairment.,2012,10.3109/1354750x.2012.677066,https://pubmed.ncbi.nlm.nih.gov/22509975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BW1,ENSG00000123569,Neither,19583817,Functional polymorphism in H2BFWT-5'UTR is associated with susceptibility to male infertility.,2009,10.1111/j.1582-4934.2009.00830.x,https://pubmed.ncbi.nlm.nih.gov/19583817/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BW1,ENSG00000123569,Neither,16449661,The NH2 tail of the novel histone variant H2BFWT exhibits properties distinct from conventional H2B with respect to the assembly of mitotic chromosomes.,2006,10.1128/mcb.26.4.1518-1526.2006,https://pubmed.ncbi.nlm.nih.gov/16449661/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BW2,ENSG00000101812,Neither,37469269,X-Chromosome Association Study in Latin American Cohorts Identifies New Loci in Parkinson's Disease.,2023,10.1002/mds.29508,https://pubmed.ncbi.nlm.nih.gov/37469269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BW2,ENSG00000101812,Neither,33664766,Identification of Potential Driver Genes Based on Multi-Genomic Data in Cervical Cancer.,2021,10.3389/fgene.2021.598304,https://pubmed.ncbi.nlm.nih.gov/33664766/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BW2,ENSG00000101812,Neither,26998479,Whole Exome- and mRNA-Sequencing of an AT/RT Case Reveals Few Somatic Mutations and Several Deregulated Signalling Pathways in the Context of SMARCB1 Deficiency.,2015,10.1155/2015/862039,https://pubmed.ncbi.nlm.nih.gov/26998479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BW2,ENSG00000101812,Neither,30859901,"Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation.",2019,10.1080/15548627.2019.1591672,https://pubmed.ncbi.nlm.nih.gov/30859901/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,39237585,New dual inducible cellular model to investigate temporal control of oncogenic cooperating genes.,2024,10.1038/s41598-024-71227-3,https://pubmed.ncbi.nlm.nih.gov/39237585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,40490365,Transcriptome Analysis Suggested Striking Transition Around the End of Epiboly in the Gene Regulatory Network Downstream of the Oct4-Type POU Gene in Zebrafish Embryos.,2025,10.1111/dgd.70012,https://pubmed.ncbi.nlm.nih.gov/40490365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,36696714,Zebrafish her3 knockout impacts developmental and cancer-related gene signatures.,2023,10.1016/j.ydbio.2023.01.003,https://pubmed.ncbi.nlm.nih.gov/36696714/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,30911281,"Hes3 Enhances the Malignant Phenotype of Lung Cancer through Upregulating Cyclin D1, Cyclin D3 and MMP7 Expression.",2019,10.7150/ijms.28139,https://pubmed.ncbi.nlm.nih.gov/30911281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,41673880,"Antibacterial potential, DNA binding and molecular docking investigations of newly green synthesized zinc oxide/chitosan/vancomycin nanocomposite using Bacillus licheniformis ATCC 4527 against some drug-resistant bacteria.",2026,10.1186/s12934-026-02928-9,https://pubmed.ncbi.nlm.nih.gov/41673880/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,30054579,"Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain.",2018,10.1038/s41598-018-29434-2,https://pubmed.ncbi.nlm.nih.gov/30054579/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,35210385,Upregulated NOTCH Signaling in the Lens of Patients With Pseudoexfoliation Syndrome Compared With Pseudoexfoliation Glaucoma Suggests Protective Role.,2022,10.1097/ijg.0000000000001975,https://pubmed.ncbi.nlm.nih.gov/35210385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,30016640,The b-HLH transcription factor Hes3 participates in neural plate border formation by interfering with Wnt/β-catenin signaling.,2018,10.1016/j.ydbio.2018.07.011,https://pubmed.ncbi.nlm.nih.gov/30016640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,29869612,PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis.,2018,10.7554/elife.33800,https://pubmed.ncbi.nlm.nih.gov/29869612/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,31145643,Controlling distinct signaling states in cultured cancer cells provides a new platform for drug discovery.,2019,10.1096/fj.201802603rr,https://pubmed.ncbi.nlm.nih.gov/31145643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,27018293,Hes3 expression in the adult mouse brain is regulated during demyelination and remyelination.,2016,10.1016/j.brainres.2016.03.014,https://pubmed.ncbi.nlm.nih.gov/27018293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,32094111,Oscillatory expression of Hes1 regulates cell proliferation and neuronal differentiation in the embryonic brain.,2020,10.1242/dev.182204,https://pubmed.ncbi.nlm.nih.gov/32094111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,25371201,"Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release.",2014,10.1074/jbc.m114.590687,https://pubmed.ncbi.nlm.nih.gov/25371201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,33636226,DNMT3L promotes neural differentiation by enhancing STAT1 and STAT3 phosphorylation independent of DNA methylation.,2021,10.1016/j.pneurobio.2021.102028,https://pubmed.ncbi.nlm.nih.gov/33636226/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,36898841,Pathogenic variations in MAML2 and MAMLD1 contribute to congenital hypothyroidism due to dyshormonogenesis by regulating the Notch signalling pathway.,2023,10.1136/jmg-2022-108866,https://pubmed.ncbi.nlm.nih.gov/36898841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,32939224,Non-classical 1p36 deletion in a patient with Duane retraction syndrome: case report and literature review.,2020,10.1186/s13039-020-00510-5,https://pubmed.ncbi.nlm.nih.gov/32939224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,32376282,HYDIN loss-of-function inhibits GATA4 expression and enhances atrial septal defect risk.,2020,10.1016/j.mod.2020.103611,https://pubmed.ncbi.nlm.nih.gov/32376282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,24101906,The STAT3-Ser/Hes3 signaling axis: an emerging regulator of endogenous regeneration and cancer growth.,2013,10.3389/fphys.2013.00273,https://pubmed.ncbi.nlm.nih.gov/24101906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,24512568,"Expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium.",2014,10.3109/09553002.2014.892228,https://pubmed.ncbi.nlm.nih.gov/24512568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,24855275,"A defined, controlled culture system for primary bovine chromaffin progenitors reveals novel biomarkers and modulators.",2014,10.5966/sctm.2013-0211,https://pubmed.ncbi.nlm.nih.gov/24855275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,32120775,Cyclooxygenases Inhibitors Efficiently Induce Cardiomyogenesis in Human Pluripotent Stem Cells.,2020,10.3390/cells9030554,https://pubmed.ncbi.nlm.nih.gov/32120775/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,31326446,"Toxicogenomic analyses of the effects of BDE-47/209, TBBPA/S and TCBPA on early neural development with a human embryonic stem cell in vitro differentiation system.",2019,10.1016/j.taap.2019.114685,https://pubmed.ncbi.nlm.nih.gov/31326446/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,30200437,Knockdown of Butyrylcholinesterase but Not Inhibition by Chlorpyrifos Alters Early Differentiation Mechanisms in Human Neural Stem Cells.,2018,10.3390/toxics6030052,https://pubmed.ncbi.nlm.nih.gov/30200437/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,30512016,Polysome profiling followed by RNA-seq of cardiac differentiation stages in hESCs.,2018,10.1038/sdata.2018.287,https://pubmed.ncbi.nlm.nih.gov/30512016/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,19438511,Statins inhibit the growth of variant human embryonic stem cells and cancer cells in vitro but not normal human embryonic stem cells.,2009,10.1111/j.1476-5381.2009.00241.x,https://pubmed.ncbi.nlm.nih.gov/19438511/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,22806875,Biomarker and pharmacologic evaluation of the γ-secretase inhibitor PF-03084014 in breast cancer models.,2012,10.1158/1078-0432.ccr-12-1379,https://pubmed.ncbi.nlm.nih.gov/22806875/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,18574770,Highly enriched cardiomyocytes from human embryonic stem cells.,2008,10.1080/14653240802105307,https://pubmed.ncbi.nlm.nih.gov/18574770/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,21663414,Notch receptor and effector expression in von Hippel-Lindau disease-associated central nervous system hemangioblastomas.,2011,10.3171/2011.5.jns11271,https://pubmed.ncbi.nlm.nih.gov/21663414/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HES3,ENSG00000173673,Neither,17707399,Survival and maturation of human embryonic stem cell-derived cardiomyocytes in rat hearts.,2007,10.1016/j.yjmcc.2007.07.001,https://pubmed.ncbi.nlm.nih.gov/17707399/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,42722060,Unraveling cadaverine toxicity effect to guide the engineering of robust strain.,2026,10.1016/j.ymben.2026.102550,https://pubmed.ncbi.nlm.nih.gov/42722060/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,36255054,Tissue-specific mitochondrial HIGD1C promotes oxygen sensitivity in carotid body chemoreceptors.,2022,10.7554/elife.78915,https://pubmed.ncbi.nlm.nih.gov/36255054/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,41507964,Metabolic engineering of Escherichia coli BW25113 for the production of Vitamin K&lt;sub&gt;2&lt;/sub&gt; based on CRISPR/Cas9 mediated gene knockout and metabolic pathway modification.,2026,10.1186/s13036-025-00614-9,https://pubmed.ncbi.nlm.nih.gov/41507964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,39857775,Differential Gene Expression Analysis in a Lumbar Spinal Stenosis Rat Model via RNA Sequencing: Identification of Key Molecular Pathways and Therapeutic Insights.,2025,10.3390/biomedicines13010192,https://pubmed.ncbi.nlm.nih.gov/39857775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,37477936,The evolution of strictly monofunctional naphthoquinol C-methyltransferases is vital in cyanobacteria and plastids.,2023,10.1093/plcell/koad202,https://pubmed.ncbi.nlm.nih.gov/37477936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,33755417,Highly Efficient Production of Menaquinone-7 from Glucose by Metabolically Engineered Escherichia coli.,2021,10.1021/acssynbio.0c00568,https://pubmed.ncbi.nlm.nih.gov/33755417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,32737601,Menaquinone-7 production in engineered Escherichia coli.,2020,10.1007/s11274-020-02880-9,https://pubmed.ncbi.nlm.nih.gov/32737601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,36417754,"Mycobacterial MenG: Partial Purification, Characterization, and Inhibition.",2022,10.1021/acsinfecdis.2c00190,https://pubmed.ncbi.nlm.nih.gov/36417754/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,27245674,Phenotypic and genetic changes in the life cycle of small colony variants of Salmonella enterica serotype Typhimurium induced by streptomycin.,2016,10.1186/s12941-016-0151-3,https://pubmed.ncbi.nlm.nih.gov/27245674/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,25817210,Identification and elimination of metabolic bottlenecks in the quinone modification pathway for enhanced coenzyme Q10 production in Rhodobacter sphaeroides.,2015,10.1016/j.ymben.2015.03.012,https://pubmed.ncbi.nlm.nih.gov/25817210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,28634238,Electron Transport Chain Is Biochemically Linked to Pilus Assembly Required for Polymicrobial Interactions and Biofilm Formation in the Gram-Positive Actinobacterium Actinomyces oris.,2017,10.1128/mbio.00399-17,https://pubmed.ncbi.nlm.nih.gov/28634238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,32271543,Introduction of the Menaquinone Biosynthetic Pathway into Rhodobacter sphaeroides and de Novo Synthesis of Menaquinone for Incorporation into Heterologously Expressed Integral Membrane Proteins.,2020,10.1021/acssynbio.0c00066,https://pubmed.ncbi.nlm.nih.gov/32271543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,30858845,Redirecting an Anticancer to an Antibacterial Hit Against Methicillin-Resistant Staphylococcus aureus.,2019,10.3389/fmicb.2019.00350,https://pubmed.ncbi.nlm.nih.gov/30858845/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,24142253,"ubiJ, a new gene required for aerobic growth and proliferation in macrophage, is involved in coenzyme Q biosynthesis in Escherichia coli and Salmonella enterica serovar Typhimurium.",2014,10.1128/jb.01065-13,https://pubmed.ncbi.nlm.nih.gov/24142253/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,16391146,Expression of the ubiE gene of Geobacillus stearothermophilus V in Escherichia coli K-12 mediates the evolution of selenium compounds into the headspace of selenite- and selenate-amended cultures.,2006,10.1128/aem.72.1.963-967.2006,https://pubmed.ncbi.nlm.nih.gov/16391146/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,21445887,Metabolic engineering of menaquinone-8 pathway of Escherichia coli as a microbial platform for vitamin K production.,2011,10.1002/bit.23142,https://pubmed.ncbi.nlm.nih.gov/21445887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,23316042,Characterization of Escherichia coli D-cycloserine transport and resistant mutants.,2013,10.1128/jb.01598-12,https://pubmed.ncbi.nlm.nih.gov/23316042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,10960098,"Identification of Escherichia coli ubiB, a gene required for the first monooxygenase step in ubiquinone biosynthesis.",2000,10.1128/jb.182.18.5139-5146.2000,https://pubmed.ncbi.nlm.nih.gov/10960098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,9045837,A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene.,1997,10.1128/jb.179.5.1748-1754.1997,https://pubmed.ncbi.nlm.nih.gov/9045837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,11738826,Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins.,2001,10.1016/s0378-1119(01)00770-3,https://pubmed.ncbi.nlm.nih.gov/11738826/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIGD1C,ENSG00000214511,Neither,32865504,Impact of a Commercial Artificial Intelligence-Driven Patient Self-Assessment Solution on Waiting Times at General Internal Medicine Outpatient Departments: Retrospective Study.,2020,10.2196/21056,https://pubmed.ncbi.nlm.nih.gov/32865504/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HNRNPCL1,ENSG00000179172,Neither,35719132,Comprehensive analysis of spliceosome genes and their mutants across 27 cancer types in 9070 patients: clinically relevant outcomes in the context of 3P medicine.,2022,10.1007/s13167-022-00279-0,https://pubmed.ncbi.nlm.nih.gov/35719132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HNRNPCL1,ENSG00000179172,Neither,37589421,N6-methyladenosine methylation regulatory pattern of pulmonary lymphoepithelioma-like carcinoma based on exosomal transcriptome analysis.,2023,10.1002/mc.23619,https://pubmed.ncbi.nlm.nih.gov/37589421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HNRNPCL1,ENSG00000179172,Neither,33177874,"HNRNPCL1, PRAMEF1, CFAP74, and DFFB: Common Potential Biomarkers for Sporadic and Suspected Lynch Syndrome Endometrial Cancer.",2020,10.2147/cmar.s262421,https://pubmed.ncbi.nlm.nih.gov/33177874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HNRNPCL1,ENSG00000179172,Neither,34386035,Predictive Biomarkers of Dicycloplatin Resistance or Susceptibility in Prostate Cancer.,2021,10.3389/fgene.2021.669605,https://pubmed.ncbi.nlm.nih.gov/34386035/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HNRNPCL1,ENSG00000179172,Neither,27171439,Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.,2016,10.1371/journal.pone.0155660,https://pubmed.ncbi.nlm.nih.gov/27171439/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HNRNPCL1,ENSG00000179172,Neither,21660214,Genomic Copy Number Analysis in Alzheimer's Disease and Mild Cognitive Impairment: An ADNI Study.,2011,10.4061/2011/729478,https://pubmed.ncbi.nlm.nih.gov/21660214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HNRNPCL1,ENSG00000179172,Neither,25924657,Concurrent exome-targeted next-generation sequencing and single nucleotide polymorphism array to identify the causative genetic aberrations of isolated Mayer-Rokitansky-Küster-Hauser syndrome.,2015,10.1093/humrep/dev095,https://pubmed.ncbi.nlm.nih.gov/25924657/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HNRNPCL2,ENSG00000275774,Neither,33219048,RNA-binding protein RALY reprogrammes mitochondrial metabolism via mediating miRNA processing in colorectal cancer.,2021,10.1136/gutjnl-2020-320652,https://pubmed.ncbi.nlm.nih.gov/33219048/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HNRNPCL2,ENSG00000275774,Neither,31917138,Proteome and miRNome profiling of microvesicles derived from medulloblastoma cell lines with stem-like properties reveals biomarkers of poor prognosis.,2020,10.1016/j.brainres.2020.146646,https://pubmed.ncbi.nlm.nih.gov/31917138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HNRNPCL2,ENSG00000275774,Neither,33177874,"HNRNPCL1, PRAMEF1, CFAP74, and DFFB: Common Potential Biomarkers for Sporadic and Suspected Lynch Syndrome Endometrial Cancer.",2020,10.2147/cmar.s262421,https://pubmed.ncbi.nlm.nih.gov/33177874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HNRNPCL4,ENSG00000179412,Neither,31917138,Proteome and miRNome profiling of microvesicles derived from medulloblastoma cell lines with stem-like properties reveals biomarkers of poor prognosis.,2020,10.1016/j.brainres.2020.146646,https://pubmed.ncbi.nlm.nih.gov/31917138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,42493501,SYCP2 recruits HORMAD2 to chromosome axes for unsynapsed chromatin silencing and synapsis surveillance in meiosis.,2026,10.1038/s41467-026-75839-3,https://pubmed.ncbi.nlm.nih.gov/42493501/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,42854377,Meiotic recombination proteins in cancer.,2026,10.1016/j.dnarep.2026.103963,https://pubmed.ncbi.nlm.nih.gov/42854377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,42216099,Neddylation is indispensable for early meiotic progression in spermatocytes via destabilizing HORMAD1 by SCF ubiquitin E3 ligase during synapsis.,2026,10.1186/s13578-026-01597-w,https://pubmed.ncbi.nlm.nih.gov/42216099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,41813673,Tumour specific HORMAD1 expression perturbs mitotic arrest and drives sensitivity to mitotic kinase inhibitors.,2026,10.1038/s41467-026-69561-3,https://pubmed.ncbi.nlm.nih.gov/41813673/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,42792869,Ubc9 Mediates SUMO2/3 Modification to Regulate Meiosis in Male Mice.,2026,10.3390/biomedicines14092129,https://pubmed.ncbi.nlm.nih.gov/42792869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,42309673,Targeting &lt;i&gt;HORMAD1&lt;/i&gt; splicing enhances MEK inhibitor sensitivity in breast cancers.,2026,10.1261/rna.081080.126,https://pubmed.ncbi.nlm.nih.gov/42309673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,41868954,HORMAD1 inhibits senescence and promotes proliferation of triple negative breast cancer by facilitating ubiquitination-mediated degradation of p27.,2026,10.62347/ivei7883,https://pubmed.ncbi.nlm.nih.gov/41868954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,40875139,HORMAD1 Polymorphisms Influence Susceptibility to Esophageal Squamous Cell Carcinoma Through Gene-Smoking Interaction.,2025,10.1002/mc.70039,https://pubmed.ncbi.nlm.nih.gov/40875139/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,40050306,Aberrant activation of chromosome asynapsis checkpoint triggers oocyte elimination.,2025,10.1038/s41467-025-57702-z,https://pubmed.ncbi.nlm.nih.gov/40050306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,40488668,CNTD1 is crucial for crossover formation in female meiosis and for establishing the ovarian reserve.,2025,10.1083/jcb.202401021,https://pubmed.ncbi.nlm.nih.gov/40488668/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,42059593,"The synaptonemal complex: structure, function, and clinical implications†.",2026,10.1093/biolre/ioag092,https://pubmed.ncbi.nlm.nih.gov/42059593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,37371097,Ectopically Expressed Meiosis-Specific Cancer Testis Antigen HORMAD1 Promotes Genomic Instability in Squamous Cell Carcinomas.,2023,10.3390/cells12121627,https://pubmed.ncbi.nlm.nih.gov/37371097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,41339899,"Genetic and epigenetic insights into non-obstructive azoospermia: mechanisms, biomarkers, and clinical perspectives.",2025,10.1186/s12958-025-01497-7,https://pubmed.ncbi.nlm.nih.gov/41339899/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,37854207,The cancer/testis antigen HORMAD1 promotes gastric cancer progression by activating the NF-κB signaling pathway and inducing epithelial-mesenchymal transition.,2023,,https://pubmed.ncbi.nlm.nih.gov/37854207/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,38467851,A novel bioinformatic approach reveals cooperation between Cancer/Testis genes in basal-like breast tumors.,2024,10.1038/s41388-024-03002-7,https://pubmed.ncbi.nlm.nih.gov/38467851/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,42193858,Population Structure Analysis and Candidate Gene Screening for Twinning Trait in Simmental Cattle.,2026,10.3390/ani16101567,https://pubmed.ncbi.nlm.nih.gov/42193858/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,41630032,Therapeutic synergies that overcome carboplatin resistance in triple-negative breast cancer.,2026,10.1186/s13046-025-03636-9,https://pubmed.ncbi.nlm.nih.gov/41630032/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,38401263,The N-terminal modification of HORMAD2 causes its ectopic persistence on synapsed chromosomes without meiotic blockade.,2024,10.1530/rep-23-0330,https://pubmed.ncbi.nlm.nih.gov/38401263/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,38580643,Seeding the meiotic DNA break machinery and initiating recombination on chromosome axes.,2024,10.1038/s41467-024-47020-1,https://pubmed.ncbi.nlm.nih.gov/38580643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,38185961,Expression of HORMAD1 in Chronic Rhinosinusitis and Its Correlation with Inflammatory Factors.,2024,10.29271/jcpsp.2024.01.54,https://pubmed.ncbi.nlm.nih.gov/38185961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,35347116,The cancer/testis antigen HORMAD1 mediates epithelial-mesenchymal transition to promote tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway in lung cancer.,2022,10.1038/s41420-022-00946-1,https://pubmed.ncbi.nlm.nih.gov/35347116/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,36524333,A biallelic loss of function variant in HORMAD1 within a large consanguineous Turkish family is associated with spermatogenic arrest.,2023,10.1093/humrep/deac259,https://pubmed.ncbi.nlm.nih.gov/36524333/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,39207914,TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis.,2024,10.7554/elife.92195,https://pubmed.ncbi.nlm.nih.gov/39207914/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,30185546,HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress.,2018,10.1158/0008-5472.can-18-1377,https://pubmed.ncbi.nlm.nih.gov/30185546/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,35773466,Role of GBP1 in innate immunity and potential as a tuberculosis biomarker.,2022,10.1038/s41598-022-15482-2,https://pubmed.ncbi.nlm.nih.gov/35773466/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,30333500,The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells.,2018,10.1038/s41598-018-33601-w,https://pubmed.ncbi.nlm.nih.gov/30333500/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,35896967,"Origin, evolution, and tissue-specific functions of the porcine repetitive element 1.",2022,10.1186/s12711-022-00745-3,https://pubmed.ncbi.nlm.nih.gov/35896967/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,34386035,Predictive Biomarkers of Dicycloplatin Resistance or Susceptibility in Prostate Cancer.,2021,10.3389/fgene.2021.669605,https://pubmed.ncbi.nlm.nih.gov/34386035/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,31237565,Unified single-cell analysis of testis gene regulation and pathology in five mouse strains.,2019,10.7554/elife.43966,https://pubmed.ncbi.nlm.nih.gov/31237565/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,25770156,Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers.,2015,10.1158/2159-8290.cd-14-1092,https://pubmed.ncbi.nlm.nih.gov/25770156/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,24764584,Tumor subtype-specific cancer-testis antigens as potential biomarkers and immunotherapeutic targets for cancers.,2014,10.1158/2326-6066.cir-13-0088,https://pubmed.ncbi.nlm.nih.gov/24764584/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,28659378,The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding.,2017,10.15252/embj.201797291,https://pubmed.ncbi.nlm.nih.gov/28659378/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,21413013,Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination.,2012,10.1002/ijc.26074,https://pubmed.ncbi.nlm.nih.gov/21413013/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,25446517,The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins.,2014,10.1016/j.devcel.2014.09.013,https://pubmed.ncbi.nlm.nih.gov/25446517/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HORMAD1,ENSG00000143452,Neither,15999985,"Identification of CT46/HORMAD1, an immunogenic cancer/testis antigen encoding a putative meiosis-related protein.",2005,,https://pubmed.ncbi.nlm.nih.gov/15999985/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,41914024,Heat shock transcription factors in development and disease.,2026,10.1242/dmm.052700,https://pubmed.ncbi.nlm.nih.gov/41914024/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,40923305,Testis-specific protein HSF5 is essential for proper chromatin organization and transcriptional reprogramming to drive pachynema progression.,2025,10.24272/j.issn.2095-8137.2025.019,https://pubmed.ncbi.nlm.nih.gov/40923305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,42840553,Tandem duplication upstream of &lt;i&gt;HSF5&lt;/i&gt; associates with transcript remodeling and triple-comb morphology in chickens.,2026,10.1016/j.isci.2026.117678,https://pubmed.ncbi.nlm.nih.gov/42840553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,42829918,WFS1 Deficiency Impairs PIAS4-Associated SUMOylation and Increases Ubiquitin-Mediated Spermatogenesis-Related Protein Degradation Leading to Testicular Male Infertility.,2026,10.1002/advs.78060,https://pubmed.ncbi.nlm.nih.gov/42829918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,41567493,HSF5: A novel switch for meiotic pachynema progression in male germ cells.,2026,10.1016/j.gendis.2025.101868,https://pubmed.ncbi.nlm.nih.gov/41567493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,38958533,HSF5 Deficiency Causes Male Infertility Involving Spermatogenic Arrest at Meiotic Prophase I in Humans and Mice.,2024,10.1002/advs.202402412,https://pubmed.ncbi.nlm.nih.gov/38958533/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,39162221,Meiotic chromatin-associated HSF5 is indispensable for pachynema progression and male fertility.,2024,10.1093/nar/gkae701,https://pubmed.ncbi.nlm.nih.gov/39162221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,38026183,The fusion gene hsf5-rnf43 in Nile tilapia: A potential regulator in the maintenance of testis function and sexual differentiation.,2023,10.1016/j.isci.2023.108284,https://pubmed.ncbi.nlm.nih.gov/38026183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,38684656,Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions.,2024,10.1038/s41467-024-47601-0,https://pubmed.ncbi.nlm.nih.gov/38684656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,41266967,"Spermatogenesis, hormonal fluctuations, and testicular gene expression changes in male blue catfish, Ictalurus furcatus, throughout pubescent and early adult stages of development.",2025,10.1186/s12864-025-12293-3,https://pubmed.ncbi.nlm.nih.gov/41266967/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,37206036,Heat shock factor 5 establishes the male germ-line meiotic sex chromosome inactivation through regulation of &lt;i&gt;Smarca4&lt;/i&gt;.,2023,10.1016/j.heliyon.2023.e15194,https://pubmed.ncbi.nlm.nih.gov/37206036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,42184630,Embryonic thermal programming combined with fractionated feeding induces early activation of hepatic lipid storage pathways in mule ducks.,2026,10.1016/j.psj.2026.107075,https://pubmed.ncbi.nlm.nih.gov/42184630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,42421966,"Integrating genetic, epigenetic, and clinical signatures via machine learning for robust prediction of leflunomide response in rheumatoid arthritis: a multi-center validation study.",2026,10.3389/fimmu.2026.1804485,https://pubmed.ncbi.nlm.nih.gov/42421966/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,36611846,"CLPP Depletion Causes Diplotene Arrest; Underlying Testis Mitochondrial Dysfunction Occurs with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2.",2022,10.3390/cells12010052,https://pubmed.ncbi.nlm.nih.gov/36611846/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,39911280,Melocular Evolution on Cold Temperature Adaptation of Chinese Rhesus Macaques.,2025,10.2174/0113892029301969240708094053,https://pubmed.ncbi.nlm.nih.gov/39911280/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,37188790,Transcriptomic and glycomic analyses highlight pathway-specific glycosylation alterations unique to Alzheimer's disease.,2023,10.1038/s41598-023-34787-4,https://pubmed.ncbi.nlm.nih.gov/37188790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,32440314,Heat shock factor 5 is essential for spermatogenesis in mice: Detected by a new monoclonal antibody.,2020,10.22038/ijbms.2019.38615.9155,https://pubmed.ncbi.nlm.nih.gov/32440314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,33390814,Heat shock factor 5 correlated with immune infiltration serves as a prognostic biomarker in lung adenocarcinoma.,2021,10.7150/ijms.51297,https://pubmed.ncbi.nlm.nih.gov/33390814/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,35187913,Application of CD83 and HSF5 to Identify Antemortem and Postmortem Skin Burns.,2021,10.12116/j.issn.1004-5619.2020.400401,https://pubmed.ncbi.nlm.nih.gov/35187913/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,36151082,Acute stress induces severe neural inflammation and overactivation of glucocorticoid signaling in interleukin-18-deficient mice.,2022,10.1038/s41398-022-02175-7,https://pubmed.ncbi.nlm.nih.gov/36151082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,30619476,Putative Loci Causing Early Embryonic Mortality in Duroc Swine.,2018,10.3389/fgene.2018.00655,https://pubmed.ncbi.nlm.nih.gov/30619476/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,25655489,Splice variants and seasonal expression of buffalo HSF genes.,2015,10.1007/s12192-014-0563-y,https://pubmed.ncbi.nlm.nih.gov/25655489/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF5,ENSG00000176160,Neither,8628288,Human chromosome 3 mediates growth arrest and suppression of apoptosis in microcell hybrids.,1996,10.1128/mcb.16.5.2214,https://pubmed.ncbi.nlm.nih.gov/8628288/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFX3,ENSG00000283697,Neither,35595785,X-linked palindromic gene families 4930567H17Rik and Mageb5 are dispensable for male mouse fertility.,2022,10.1038/s41598-022-12433-9,https://pubmed.ncbi.nlm.nih.gov/35595785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,42450814,Y-Linked Expression Signatures Distinguish Dysfunctional Testicular States in Sheep.,2026,10.3390/ani16132107,https://pubmed.ncbi.nlm.nih.gov/42450814/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,40457168,A guide to heat shock factors as multifunctional transcriptional regulators.,2025,10.1111/febs.70139,https://pubmed.ncbi.nlm.nih.gov/40457168/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,41897406,Divergent Amplification of Y-Linked Dosage-Sensitive Genes Triggers Regulatory Mismatch Underlying Cattle-Yak Male Sterility.,2026,10.3390/biom16030471,https://pubmed.ncbi.nlm.nih.gov/41897406/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,42510778,Isolation and Sequencing of the Y Chromosome in Mediterranean River Buffalo Using Laser Microdissection-Based NGS.,2026,10.3390/genes17070740,https://pubmed.ncbi.nlm.nih.gov/42510778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,37967251,Transcript Isoform Diversity of Ampliconic Genes on the Y Chromosome of Great Apes.,2023,10.1093/gbe/evad205,https://pubmed.ncbi.nlm.nih.gov/37967251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,36461090,Dynamic transcriptome analysis reveals the gene network of gonadal development from the early history life stages in dwarf surfclam Mulinia lateralis.,2022,10.1186/s13293-022-00479-3,https://pubmed.ncbi.nlm.nih.gov/36461090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,33467186,An 8.22 Mb Assembly and Annotation of the Alpaca (Vicugna pacos) Y Chromosome.,2021,10.3390/genes12010105,https://pubmed.ncbi.nlm.nih.gov/33467186/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,31525193,"Dosage regulation, and variation in gene expression and copy number of human Y chromosome ampliconic genes.",2019,10.1371/journal.pgen.1008369,https://pubmed.ncbi.nlm.nih.gov/31525193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,33766143,Human AZFb deletions cause distinct testicular pathologies depending on their extensions in Yq11 and the Y haplogroup: new cases and review of literature.,2021,10.1186/s13578-021-00551-2,https://pubmed.ncbi.nlm.nih.gov/33766143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,27696014,Expression pattern of HSFY in the mouse testis and epididymis with and without heat stress.,2016,10.1007/s00441-016-2482-y,https://pubmed.ncbi.nlm.nih.gov/27696014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,26162009,Isoform-Level Gene Expression Profiles of Human Y Chromosome Azoospermia Factor Genes and Their X Chromosome Paralogs in the Testicular Tissue of Non-Obstructive Azoospermia Patients.,2015,10.1021/acs.jproteome.5b00520,https://pubmed.ncbi.nlm.nih.gov/26162009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,31103297,"Comparison of Y-chromosome-linked TSPY, TSPY2, and PRAMEY genes in Taurus cattle, yaks, and interspecific hybrid bulls.",2019,10.3168/jds.2018-15680,https://pubmed.ncbi.nlm.nih.gov/31103297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,26055083,Expansion of the HSFY gene family in pig lineages : HSFY expansion in suids.,2015,10.1186/s12864-015-1650-x,https://pubmed.ncbi.nlm.nih.gov/26055083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,36402935,Functional diversification of heat shock factors.,2022,10.1007/s42977-022-00138-z,https://pubmed.ncbi.nlm.nih.gov/36402935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,34274474,Identification of genomic imbalances (CNVs as well as LOH) in sertoli cell only syndrome cases through cytoscan microarray.,2021,10.1016/j.gene.2021.145851,https://pubmed.ncbi.nlm.nih.gov/34274474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,36317206,[A multiplex PCR-based sensitive and specific method for detecting Y chromosome material in patients with Turner syndrome].,2022,10.3760/cma.j.cn511374-20211209-00978,https://pubmed.ncbi.nlm.nih.gov/36317206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,35661078,Y Chromosome Genes May Play Roles in the Development of Neural Rosettes from Human Embryonic Stem Cells.,2022,10.1007/s12015-022-10392-2,https://pubmed.ncbi.nlm.nih.gov/35661078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,24507556,"Copy number variations of the extensively amplified Y-linked genes, HSFY and ZNF280BY, in cattle and their association with male reproductive traits in Holstein bulls.",2014,10.1186/1471-2164-15-113,https://pubmed.ncbi.nlm.nih.gov/24507556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,22820855,Deletion or underexpression of the Y-chromosome genes CDY2 and HSFY is associated with maturation arrest in American men with nonobstructive azoospermia.,2012,10.1038/aja.2012.55,https://pubmed.ncbi.nlm.nih.gov/22820855/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,21408193,A large expansion of the HSFY gene family in cattle shows dispersion across Yq and testis-specific expression.,2011,10.1371/journal.pone.0017790,https://pubmed.ncbi.nlm.nih.gov/21408193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,16952509,"Altered expression pattern of heat shock transcription factor, Y chromosome (HSFY) may be related to altered differentiation of spermatogenic cells in testes with deteriorated spermatogenesis.",2006,10.1016/j.fertnstert.2006.01.053,https://pubmed.ncbi.nlm.nih.gov/16952509/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,29177647,"Targeted Deletion of Hsf1, 2, and 4 Genes in Mice.",2018,10.1007/978-1-4939-7477-1_1,https://pubmed.ncbi.nlm.nih.gov/29177647/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,21898223,"Targeted deletion of Hsf1, 2, and 4 genes in mice.",2011,10.1007/978-1-61779-295-3_1,https://pubmed.ncbi.nlm.nih.gov/21898223/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,15044259,"Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility.",2004,10.1095/biolreprod.103.023580,https://pubmed.ncbi.nlm.nih.gov/15044259/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSFY1,ENSG00000172468,Neither,12815422,The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.,2003,10.1038/nature01722,https://pubmed.ncbi.nlm.nih.gov/12815422/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,40189618,Htra4 promotes vascular endothelial cell injury and is associated with the early-onset of preeclampsia.,2025,10.1038/s41598-025-96819-5,https://pubmed.ncbi.nlm.nih.gov/40189618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,40334386,Extracellular matrix induces trophoblast HtrA4 expression: Implications for the pathogenesis of placenta accreta spectrum.,2025,10.1016/j.placenta.2025.04.028,https://pubmed.ncbi.nlm.nih.gov/40334386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,41553058,Placental Pathology and HTRA4-Mediated Autophagic Flux Disruption in Selective Fetal Growth Restriction Types I and III: A Morphological and Transcriptomic Study.,2026,10.1096/fj.202503584rr,https://pubmed.ncbi.nlm.nih.gov/41553058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,42493827,Host and &lt;i&gt;Helicobacter pylori&lt;/i&gt; HtrA protease variants converge on Wnt/β-catenin signaling to drive stomach adenocarcinoma.,2026,10.1080/19490976.2026.2704244,https://pubmed.ncbi.nlm.nih.gov/42493827/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,42473750,Multiomics integrative bioinformatics analysis of gene expression characteristics and molecular mechanisms in preeclampsia placental tissue.,2026,10.1080/21691401.2026.2697688,https://pubmed.ncbi.nlm.nih.gov/42473750/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,39934690,Identification of critical biomarkers and immune infiltration in preeclampsia through bioinformatics and machine learning methods.,2025,10.1186/s12884-025-07257-0,https://pubmed.ncbi.nlm.nih.gov/39934690/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,42475769,Placental transcriptome analysis reveals BMI-dependent gene expression profiles in preeclampsia.,2026,10.1016/j.placenta.2026.07.005,https://pubmed.ncbi.nlm.nih.gov/42475769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,38880601,Identification of HTRA4 as a Transcriptional Target of p63 in Trophoblast.,2024,10.1016/j.ajpath.2024.03.011,https://pubmed.ncbi.nlm.nih.gov/38880601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,40826226,Placental network differences among obstetric syndromes identified with an integrated multiomics approach.,2025,10.1038/s42003-025-08631-6,https://pubmed.ncbi.nlm.nih.gov/40826226/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,38717523,Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review.,2024,10.1007/s40291-024-00712-2,https://pubmed.ncbi.nlm.nih.gov/38717523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,38805949,HtrA4 is well conserved only in higher primates and functionally important for EVT differentiation.,2024,10.1016/j.placenta.2024.05.132,https://pubmed.ncbi.nlm.nih.gov/38805949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,37296580,Cellular Functions of High-Temperature Requirement Factor A4 in Placenta.,2023,10.3390/cells12111459,https://pubmed.ncbi.nlm.nih.gov/37296580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,39929934,Culture of cryopreserved first trimester placental tissues to study syncytial renewal.,2025,10.1038/s41598-025-89022-z,https://pubmed.ncbi.nlm.nih.gov/39929934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,38325051,HtrA4 is required for human trophoblast stem cell differentiation into syncytiotrophoblast.,2024,10.1016/j.placenta.2024.01.018,https://pubmed.ncbi.nlm.nih.gov/38325051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,37728094,Endoplasmic reticulum stress impairs trophoblast syncytialization through upregulation of HtrA4 and causes early-onset preeclampsia.,2023,10.1097/hjh.0000000000003541,https://pubmed.ncbi.nlm.nih.gov/37728094/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,41950693,Severe early-onset preeclampsia is significantly associated with metabolic dysregulation and sustained elevation of placental HIF-1α.,2026,10.1016/j.placenta.2026.03.020,https://pubmed.ncbi.nlm.nih.gov/41950693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,37579694,Deficiency of HtrA4 in BeWo cells downregulates angiogenesis through IL-6/JAK/STAT3 signaling.,2023,10.1016/j.biopha.2023.115288,https://pubmed.ncbi.nlm.nih.gov/37579694/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,41931203,Differential proteomic responses to short-term heat stress in Vechur and crossbred cattle of Kerala.,2026,10.1007/s11250-026-05018-5,https://pubmed.ncbi.nlm.nih.gov/41931203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,37217518,The first-trimester serum high-temperature requirement protease A4 and uterine artery Doppler for the prediction of preeclampsia.,2023,10.1038/s41598-023-35243-z,https://pubmed.ncbi.nlm.nih.gov/37217518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,38048229,Identification and validation of feature genes associated with M1 macrophages in preeclampsia.,2023,10.18632/aging.205264,https://pubmed.ncbi.nlm.nih.gov/38048229/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,40823529,Molecular signatures of preeclampsia subtypes determined through integrated weighted gene co-expression network analysis and differential gene expression analysis of placental transcriptomics.,2025,10.3389/fcell.2025.1635878,https://pubmed.ncbi.nlm.nih.gov/40823529/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,34639128,"Overview of Human HtrA Family Proteases and Their Distinctive Physiological Roles and Unique Involvement in Diseases, Especially Cancer and Pregnancy Complications.",2021,10.3390/ijms221910756,https://pubmed.ncbi.nlm.nih.gov/34639128/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,38672084,A Comprehensive Analysis of the Effect of A&gt;I(G) RNA-Editing Sites on Genotoxic Drug Response and Progression in Breast Cancer.,2024,10.3390/biomedicines12040728,https://pubmed.ncbi.nlm.nih.gov/38672084/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,30808565,"Characterization of whole blood transcriptome and early-life fecal microbiota in high and low responder pigs before, and after vaccination for Mycoplasma hyopneumoniae.",2019,10.1016/j.vaccine.2019.02.016,https://pubmed.ncbi.nlm.nih.gov/30808565/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,26899996,GATA3 inhibits GCM1 activity and trophoblast cell invasion.,2016,10.1038/srep21630,https://pubmed.ncbi.nlm.nih.gov/26899996/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,27560381,Comparison of Normal and Pre-Eclamptic Placental Gene Expression: A Systematic Review with Meta-Analysis.,2016,10.1371/journal.pone.0161504,https://pubmed.ncbi.nlm.nih.gov/27560381/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,26388242,Gene expression profiling of pre-eclamptic placentae by RNA sequencing.,2015,10.1038/srep14107,https://pubmed.ncbi.nlm.nih.gov/26388242/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTRA4,ENSG00000169495,Neither,19519315,HtrA serine proteases as potential therapeutic targets in cancer.,2009,10.2174/156800909788486704,https://pubmed.ncbi.nlm.nih.gov/19519315/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,42748574,EGR1 coordinates a nuclear IL-33-phosphorylated STAT3 transcriptional complex to promote IL31 expression in TLR1/2-activated keratinocytes.,2026,10.1016/j.bbrc.2026.154592,https://pubmed.ncbi.nlm.nih.gov/42748574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,42696560,Roles of Interleukin-31 in Allergen-Driven Cough: Linking Protease-Activated Receptor-2 Activation and Vagal Ganglion Sensitization in a Dermatophagoides farinae-Induced Asthma Model.,2026,10.1002/brb3.71731,https://pubmed.ncbi.nlm.nih.gov/42696560/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,42833928,"Corrigendum to ""EGR1 coordinates a nuclear IL-33-phosphorylated STAT3 transcriptional complex to promote IL31 expression in TLR1/2-activated keratinocytes"" [Biochem. Biophys. Res. Commun., 837 (2026) 154592].",2026,10.1016/j.bbrc.2026.154655,https://pubmed.ncbi.nlm.nih.gov/42833928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,41653653,OSMR coordinates a self-perpetuating circuit linking chemoresistance and neutrophil-driven immunosuppression in gastric cancer.,2026,10.1016/j.neo.2026.101279,https://pubmed.ncbi.nlm.nih.gov/41653653/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,42477188,Hyaluronidase attenuates radiation-induced skin fibrosis through extracellular matrix remodeling and suppression of inflammatory-profibrotic signaling.,2026,10.1007/s00210-026-05718-7,https://pubmed.ncbi.nlm.nih.gov/42477188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,40651664,IL31 identified as a key genetic risk factor for prurigo nodularis.,2025,10.1016/j.jaci.2025.06.031,https://pubmed.ncbi.nlm.nih.gov/40651664/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,38354695,Astrocyte-derived Interleukin-31 causes poor prognosis in elderly patients with intracerebral hemorrhage.,2024,10.1111/bpa.13245,https://pubmed.ncbi.nlm.nih.gov/38354695/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,40600744,Th2 mRNA gene expression analysis separates Prurigo nodularis into two immune signature groups.,2025,10.1111/jdv.20812,https://pubmed.ncbi.nlm.nih.gov/40600744/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,39767728,"Comparative Analysis of Extracorporeal Shockwave Therapy, Bisphosphonate, and Wharton Jelly-Derived Mesenchymal Stem Cells in Preserving Bone and Cartilage Integrity and Modulating IL31, IL33, and BMP2 in the Cartilage of Ovariectomized Rat Model.",2024,10.3390/biomedicines12122823,https://pubmed.ncbi.nlm.nih.gov/39767728/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,40420206,Electroacupuncture exerts antipruritic and anti-inflammatory effects on atopic dermatitis by activating CB2 receptor.,2025,10.1186/s13020-025-01102-4,https://pubmed.ncbi.nlm.nih.gov/40420206/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,42724128,Real-world effectiveness of a topical dihydroavenanthramide D formulation for chronic pruritus: A multicenter clinical study with molecular evidence of pruritogenic pathway modulation.,2026,10.52225/narra.v6i2.3116,https://pubmed.ncbi.nlm.nih.gov/42724128/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,40725084,Targeting Vascular and Inflammatory Crosstalk: Cannabigerol as a Dual-Pathway Modulator in Rosacea.,2025,10.3390/ijms26146840,https://pubmed.ncbi.nlm.nih.gov/40725084/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,41421479,Relation Between Gut Microbiome and Inflammatory Interleukins in Psoriasis Patients Compared to Healthy Controls: An Observational Study.,2026,10.1016/j.ad.2025.104579,https://pubmed.ncbi.nlm.nih.gov/41421479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,38371956,"GB12-09, a bispecific antibody targeting IL4Rα and IL31Rα for atopic dermatitis therapy.",2024,10.1093/abt/tbad032,https://pubmed.ncbi.nlm.nih.gov/38371956/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,42040572,A descriptive multilevel analysis associating COVID-19 with polymyositis: from genetic markers and candidate mediators to clinical hematological profiles.,2026,10.3389/fmed.2026.1775960,https://pubmed.ncbi.nlm.nih.gov/42040572/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,37831760,IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis.,2023,10.1126/sciimmunol.abi6887,https://pubmed.ncbi.nlm.nih.gov/37831760/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,40001968,Assessing the Causal Relationship Between Plasma Proteins and Pulmonary Fibrosis: A Systematic Analysis Based on Mendelian Randomization.,2025,10.3390/biology14020200,https://pubmed.ncbi.nlm.nih.gov/40001968/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,34027133,Serum and cutaneous transcriptional expression levels of IL31 are minimal in cutaneous T cell lymphoma variants.,2021,10.1016/j.bbrep.2021.101007,https://pubmed.ncbi.nlm.nih.gov/34027133/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,32673566,The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching.,2020,10.1016/j.immuni.2020.06.023,https://pubmed.ncbi.nlm.nih.gov/32673566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,38652814,Immunologic Profiling of Immune-Related Cutaneous Adverse Events with Checkpoint Inhibitors Reveals Polarized Actionable Pathways.,2024,10.1158/1078-0432.ccr-23-3431,https://pubmed.ncbi.nlm.nih.gov/38652814/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,35507231,Qualitative study to characterize patient experience and relevance of patient-reported outcome measures for patients with metastatic synovial sarcoma.,2022,10.1186/s41687-022-00450-1,https://pubmed.ncbi.nlm.nih.gov/35507231/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,38563683,Targeting IL-13 with tralokinumab normalizes type 2 inflammation in atopic dermatitis both early and at 2 years.,2024,10.1111/all.16108,https://pubmed.ncbi.nlm.nih.gov/38563683/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,33819507,Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound.,2021,10.1016/j.jaci.2021.03.029,https://pubmed.ncbi.nlm.nih.gov/33819507/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,34574259,Administration of Ligilactobacillus salivarius MP101 in an Elderly Nursing Home during the COVID-19 Pandemic: Immunological and Nutritional Impact.,2021,10.3390/foods10092149,https://pubmed.ncbi.nlm.nih.gov/34574259/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,37210042,Single-cell RNA sequencing defines disease-specific differences between chronic nodular prurigo and atopic dermatitis.,2023,10.1016/j.jaci.2023.04.019,https://pubmed.ncbi.nlm.nih.gov/37210042/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,37522399,Inflammation biomarkers in acute ischemic stroke according to different etiologies.,2024,10.1111/ene.16006,https://pubmed.ncbi.nlm.nih.gov/37522399/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,38999459,"Plasma Cytokines for the Prediction of the Effectiveness of TNFα Inhibitors Etanercept, Infliximab, and Adalimumab in the Treatment of Psoriasis.",2024,10.3390/jcm13133895,https://pubmed.ncbi.nlm.nih.gov/38999459/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL31,ENSG00000204671,Neither,15184896,"Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice.",2004,10.1038/ni1084,https://pubmed.ncbi.nlm.nih.gov/15184896/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCA1L,ENSG00000278685,Neither,37018908,Identification of key differentially expressed genes in SARS-CoV-2 using RNA-seq analysis with a systems biology approach.,2023,10.1016/j.cyto.2023.156187,https://pubmed.ncbi.nlm.nih.gov/37018908/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCJ,ENSG00000214216,Neither,39823074,Identification of genes associated with longevity in dogs: 9 candidate genes described in Cavalier King Charles Spaniel.,2025,10.1016/j.vas.2024.100420,https://pubmed.ncbi.nlm.nih.gov/39823074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCJ,ENSG00000214216,Neither,37984853,Sex-specific genetic architecture of late-life memory performance.,2024,10.1002/alz.13507,https://pubmed.ncbi.nlm.nih.gov/37984853/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCJ,ENSG00000214216,Neither,31205916,Long non-coding RNA IQCJ-SCHIP1 antisense RNA 1 is downregulated in colorectal cancer and inhibits cell proliferation.,2019,10.21037/atm.2019.04.21,https://pubmed.ncbi.nlm.nih.gov/31205916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCJ,ENSG00000214216,Neither,27979964,Schwannomin-interacting Protein 1 Isoform IQCJ-SCHIP1 Is a Multipartner Ankyrin- and Spectrin-binding Protein Involved in the Organization of Nodes of Ranvier.,2017,10.1074/jbc.m116.758029,https://pubmed.ncbi.nlm.nih.gov/27979964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCJ,ENSG00000214216,Neither,28787085,Homozygous nonsense mutation in SCHIP1/IQCJ-SCHIP1 causes a neurodevelopmental brain malformation syndrome.,2018,10.1111/cge.13122,https://pubmed.ncbi.nlm.nih.gov/28787085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCJ,ENSG00000214216,Neither,28134766,"Plasma Triglyceride Levels May Be Modulated by Gene Expression of IQCJ, NXPH1, PHF17 and MYB in Humans.",2017,10.3390/ijms18020257,https://pubmed.ncbi.nlm.nih.gov/28134766/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCJ,ENSG00000214216,Neither,25950943,CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.,2015,10.1111/jnc.13158,https://pubmed.ncbi.nlm.nih.gov/25950943/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCJ,ENSG00000214216,Neither,32868783,Exploring the genetic basis of fatty liver development in geese.,2020,10.1038/s41598-020-71210-8,https://pubmed.ncbi.nlm.nih.gov/32868783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCJ,ENSG00000214216,Neither,33292187,A systems biology framework integrating GWAS and RNA-seq to shed light on the molecular basis of sperm quality in swine.,2020,10.1186/s12711-020-00592-0,https://pubmed.ncbi.nlm.nih.gov/33292187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCJ,ENSG00000214216,Neither,18550753,Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late component of nodes of Ranvier and axon initial segments.,2008,10.1523/jneurosci.1044-08.2008,https://pubmed.ncbi.nlm.nih.gov/18550753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCJ,ENSG00000214216,Neither,25953347,"The cytoskeleton-associated protein SCHIP1 is involved in axon guidance, and is required for piriform cortex and anterior commissure development.",2015,10.1242/dev.119248,https://pubmed.ncbi.nlm.nih.gov/25953347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCJ,ENSG00000214216,Neither,31889940,The plasma peptides of breast versus ovarian cancer.,2019,10.1186/s12014-019-9262-0,https://pubmed.ncbi.nlm.nih.gov/31889940/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCJ,ENSG00000214216,Neither,17045569,"IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein.",2006,10.1016/j.bbrc.2006.09.136,https://pubmed.ncbi.nlm.nih.gov/17045569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCJ,ENSG00000214216,Neither,30911093,Genome-wide association study of blood lipids in Indians confirms universality of established variants.,2019,10.1038/s10038-019-0591-7,https://pubmed.ncbi.nlm.nih.gov/30911093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCJ,ENSG00000214216,Neither,24847101,Genome-wide association study of the plasma triglyceride response to an n-3 polyunsaturated fatty acid supplementation.,2014,10.1194/jlr.m045898,https://pubmed.ncbi.nlm.nih.gov/24847101/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCM,ENSG00000234828,Neither,42061264,A long non-coding RNA-messenger RNA regulatory network associated with residual feed intake in the olfactory tissue of meat ducks.,2026,10.1016/j.psj.2026.107005,https://pubmed.ncbi.nlm.nih.gov/42061264/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,40760720,Uncovering the Role of IZUMO Family Members in Human Fertilization.,2025,10.1002/mrd.70040,https://pubmed.ncbi.nlm.nih.gov/40760720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,38484656,Expression of IZUMO2 in colorectal cancer in association with clinicopathological features.,2024,10.1016/j.prp.2024.155263,https://pubmed.ncbi.nlm.nih.gov/38484656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,40563931,scRL: Utilizing Reinforcement Learning to Evaluate Fate Decisions in Single-Cell Data.,2025,10.3390/biology14060679,https://pubmed.ncbi.nlm.nih.gov/40563931/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,40409516,Deciphering the regulatory networks of human male germline development from embryo to adulthood.,2025,10.1016/j.bbadis.2025.167918,https://pubmed.ncbi.nlm.nih.gov/40409516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,42591449,A radiotherapy resistance-related prognostic signature predicts survival and the immune landscape in rectal cancer.,2026,10.21037/tcr-2026-0554,https://pubmed.ncbi.nlm.nih.gov/42591449/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,38966714,Stochastic calculus-guided reinforcement learning: A probabilistic framework for optimal decision-making.,2024,10.1016/j.mex.2024.102790,https://pubmed.ncbi.nlm.nih.gov/38966714/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,42518043,"Cross-species comparative transcriptomic analysis of spermatozoa reveals species-specific regulatory networks linked to fertilization-associated genes in cattle, sheep and goats.",2026,10.1007/s11427-024-3211-6,https://pubmed.ncbi.nlm.nih.gov/42518043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,38258402,Implication of IZUMO2 in the cell-in-cell phenomenon: A potential therapeutic target for triple-negative breast cancer.,2024,10.1111/1759-7714.15189,https://pubmed.ncbi.nlm.nih.gov/38258402/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,32553959,Identification of new protein biomarkers associated with the boar fertility using iTRAQ-based quantitative proteomic analysis.,2020,10.1016/j.ijbiomac.2020.06.102,https://pubmed.ncbi.nlm.nih.gov/32553959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,39038345,"Relationship Between Serum MMP-2, Siglec-1, Th1/Th2 Cell Ratio, and Disease Activity in Rheumatoid Arthritis.",2024,,https://pubmed.ncbi.nlm.nih.gov/39038345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,38907796,IcmF2 of the type VI secretion system 2 plays a role in biofilm formation of Vibrio parahaemolyticus.,2024,10.1007/s00203-024-04060-x,https://pubmed.ncbi.nlm.nih.gov/38907796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,33075640,Sequential conditional reinforcement learning for simultaneous vertebral body detection and segmentation with modeling the spine anatomy.,2021,10.1016/j.media.2020.101861,https://pubmed.ncbi.nlm.nih.gov/33075640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,33203797,Analysis of DNA methylation-driven genes for predicting the prognosis of patients with colorectal cancer.,2020,10.18632/aging.103949,https://pubmed.ncbi.nlm.nih.gov/33203797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,33199284,Identification of Three New GGDEF and EAL Domain-Containing Proteins Participating in the Scr Surface Colonization Regulatory Network in Vibrio parahaemolyticus.,2021,10.1128/jb.00409-20,https://pubmed.ncbi.nlm.nih.gov/33199284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,28906557,The unusual S locus of Leavenworthia is composed of two sets of paralogous loci.,2017,10.1111/nph.14764,https://pubmed.ncbi.nlm.nih.gov/28906557/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,28977434,Network embedding-based representation learning for single cell RNA-seq data.,2017,10.1093/nar/gkx750,https://pubmed.ncbi.nlm.nih.gov/28977434/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,23279005,Presence and incidence of izumo antibodies in sera of immunoinfertile women and men.,2013,10.1111/aji.12060,https://pubmed.ncbi.nlm.nih.gov/23279005/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,19106485,Fetal age estimation of Hokkaido sika deer (Cervus nippon yesoensis) using ultrasonography during early pregnancy.,2009,10.1262/jrd.20113,https://pubmed.ncbi.nlm.nih.gov/19106485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,12594216,Effect of glycosylphosphatidylinositol anchor-dependent and -independent prion protein association with model raft membranes on conversion to the protease-resistant isoform.,2003,10.1074/jbc.m210840200,https://pubmed.ncbi.nlm.nih.gov/12594216/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO2,ENSG00000161652,Neither,18984037,Induction of type III secretion by cell-free Chlamydia trachomatis elementary bodies.,2008,10.1016/j.micpath.2008.10.002,https://pubmed.ncbi.nlm.nih.gov/18984037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA10,ENSG00000143105,Neither,40908485,Early downregulation of hair cell (HC)-specific genes in the vestibular sensory epithelium during chronic ototoxicity.,2025,10.1186/s12929-025-01180-4,https://pubmed.ncbi.nlm.nih.gov/40908485/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA10,ENSG00000143105,Neither,39625061,The potassium channel subunit KV1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells.,2024,10.7554/elife.94342,https://pubmed.ncbi.nlm.nih.gov/39625061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA10,ENSG00000143105,Neither,40860865,Escalated oxycodone self-administration is associated with expression of voltage gated and calcium activated potassium channels in the mesocorticolimbic system in rats.,2025,10.3389/fphar.2025.1653356,https://pubmed.ncbi.nlm.nih.gov/40860865/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA10,ENSG00000143105,Neither,38956042,"Whole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals.",2024,10.1038/s41467-024-49702-2,https://pubmed.ncbi.nlm.nih.gov/38956042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA10,ENSG00000143105,Neither,40675770,Genomics of chronic dry cough unravels neurological pathways.,2025,10.1183/13993003.02341-2024,https://pubmed.ncbi.nlm.nih.gov/40675770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA10,ENSG00000143105,Neither,36696070,Association of Single Nucleotide Polymorphisms in KCNA10 and SLC13A3 Genes with the Susceptibility to Chronic Kidney Disease of Unknown Etiology in Central Indian Patients.,2023,10.1007/s10528-023-10335-7,https://pubmed.ncbi.nlm.nih.gov/36696070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA10,ENSG00000143105,Neither,34051764,Authentication of differential gene expression in oral squamous cell carcinoma using machine learning applications.,2021,10.1186/s12903-021-01642-9,https://pubmed.ncbi.nlm.nih.gov/34051764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA10,ENSG00000143105,Neither,36631626,"Transcriptome Analysis Revealed Osmoregulation Related Regulatory Networks and Hub Genes in the Gills of Hilsa shad, Tenualosa ilisha, during the Migratory Osmotic Stress.",2023,10.1007/s10126-022-10190-4,https://pubmed.ncbi.nlm.nih.gov/36631626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA10,ENSG00000143105,Neither,23528307,A null mutation of mouse Kcna10 causes significant vestibular and mild hearing dysfunction.,2013,10.1016/j.heares.2013.02.009,https://pubmed.ncbi.nlm.nih.gov/23528307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA10,ENSG00000143105,Neither,22446089,"Specific expression of Kcna10, Pxn and Odf2 in the organ of Corti.",2012,10.1016/j.gep.2012.03.001,https://pubmed.ncbi.nlm.nih.gov/22446089/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA10,ENSG00000143105,Neither,28431800,Genetic predictors of antipsychotic response to lurasidone identified in a genome wide association study and by schizophrenia risk genes.,2018,10.1016/j.schres.2017.04.009,https://pubmed.ncbi.nlm.nih.gov/28431800/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA10,ENSG00000143105,Neither,12444201,"Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule.",2002,10.1097/01.asn.0000036866.37886.c5,https://pubmed.ncbi.nlm.nih.gov/12444201/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA10,ENSG00000143105,Neither,12060596,"Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit.",2002,10.1152/ajprenal.00258.2001,https://pubmed.ncbi.nlm.nih.gov/12060596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA10,ENSG00000143105,Neither,26108971,"Whole-exome sequencing reveals genetic variants associated with chronic kidney disease characterized by tubulointerstitial damages in North Central Region, Sri Lanka.",2015,10.1007/s12199-015-0475-1,https://pubmed.ncbi.nlm.nih.gov/26108971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA10,ENSG00000143105,Neither,15135220,Molecular cloning and partial functional characterization of Tsha3--a novel modulatory potassium channel alpha-subunit of trout CNS.,2004,10.1016/j.molbrainres.2004.02.016,https://pubmed.ncbi.nlm.nih.gov/15135220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA10,ENSG00000143105,Neither,10836990,KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels.,2000,10.1152/ajprenal.2000.278.6.f1013,https://pubmed.ncbi.nlm.nih.gov/10836990/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA10,ENSG00000143105,Neither,16815889,Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells.,2006,10.1152/ajplung.00191.2005,https://pubmed.ncbi.nlm.nih.gov/16815889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA10,ENSG00000143105,Neither,15300162,Renal potassium channels: recent developments.,2004,10.1097/00041552-200409000-00011,https://pubmed.ncbi.nlm.nih.gov/15300162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4B,ENSG00000226650,Neither,42512966,KIF4A-KIF4B Paralog as a Prognostic Biomarker in Lung Adenocarcinoma.,2026,10.3390/medicina62071424,https://pubmed.ncbi.nlm.nih.gov/42512966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4B,ENSG00000226650,Neither,29325163,Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations.,2018,10.1210/jc.2017-01802,https://pubmed.ncbi.nlm.nih.gov/29325163/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4B,ENSG00000226650,Neither,28901309,Kinesin superfamily protein expression and its association with progression and prognosis in hepatocellular carcinoma.,2017,10.4103/jcrt.jcrt_491_17,https://pubmed.ncbi.nlm.nih.gov/28901309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4B,ENSG00000226650,Neither,15547729,KIF27 is one of orthologs for Drosophila Costal-2.,2004,10.3892/ijo.25.6.1875,https://pubmed.ncbi.nlm.nih.gov/15547729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4B,ENSG00000226650,Neither,16201836,Emergence of young human genes after a burst of retroposition in primates.,2005,10.1371/journal.pbio.0030357,https://pubmed.ncbi.nlm.nih.gov/16201836/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT26,ENSG00000186393,Neither,42738544,Early Compound Nutritional Intervention Improves Hair Follicle Development in Northwest Xizang White Cashmere Goats: An Analysis Based on Skin Multi-Omics.,2026,10.3390/ani16172756,https://pubmed.ncbi.nlm.nih.gov/42738544/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT26,ENSG00000186393,Neither,40141352,Proteomics Reveals the Role of PLIN2 in Regulating the Secondary Hair Follicle Cycle in Cashmere Goats.,2025,10.3390/ijms26062710,https://pubmed.ncbi.nlm.nih.gov/40141352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT26,ENSG00000186393,Neither,40941372,Screening of Protein Related to Wool Development and Fineness in Gansu Alpine Fine-Wool Sheep.,2025,10.3390/ani15172578,https://pubmed.ncbi.nlm.nih.gov/40941372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT26,ENSG00000186393,Neither,41427131,Transcriptome sequencing reveals the key genes associated with hair follicle development in Qianhua Mutton Merino.,2025,10.3389/fvets.2025.1699868,https://pubmed.ncbi.nlm.nih.gov/41427131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT26,ENSG00000186393,Neither,38971547,Study on the expression patterns of inner root sheath-specific genes in Tan sheep hair follicle during different developmental stages.,2024,10.1016/j.gene.2024.148751,https://pubmed.ncbi.nlm.nih.gov/38971547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT26,ENSG00000186393,Neither,38873117,"Whole-genome resequencing reveals genetic diversity, differentiation, and selection signatures of yak breeds/populations in southwestern China.",2024,10.3389/fgene.2024.1382128,https://pubmed.ncbi.nlm.nih.gov/38873117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT26,ENSG00000186393,Neither,33240606,Integrated analysis of lncRNA and mRNA reveals novel insights into cashmere fineness in Tibetan cashmere goats.,2020,10.7717/peerj.10217,https://pubmed.ncbi.nlm.nih.gov/33240606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT26,ENSG00000186393,Neither,26612660,Genome-wide scan for selection signatures in six cattle breeds in South Africa.,2015,10.1186/s12711-015-0173-x,https://pubmed.ncbi.nlm.nih.gov/26612660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT26,ENSG00000186393,Neither,16874310,"K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle.",2006,10.1038/sj.jid.5700494,https://pubmed.ncbi.nlm.nih.gov/16874310/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT26,ENSG00000186393,Neither,15617563,The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain.,2004,10.1111/j.1432-0436.2004.07209006.x,https://pubmed.ncbi.nlm.nih.gov/15617563/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP10-12,ENSG00000189169,Neither,36596724,Identification of Genes Involved in EGF-induced Apoptosis Using CRISPR/Cas9 Knockout Screening: Implications for Novel Therapeutic Targets in EGFR-Overexpressing Cancers.,2023,10.4143/crt.2022.1414,https://pubmed.ncbi.nlm.nih.gov/36596724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP10-12,ENSG00000189169,Neither,28865488,Distinct transcriptional and metabolic profiles associated with empathy in Buddhist priests: a pilot study.,2017,10.1186/s40246-017-0117-3,https://pubmed.ncbi.nlm.nih.gov/28865488/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP10-12,ENSG00000189169,Neither,15028290,A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3.,2004,10.1016/j.ygeno.2003.09.024,https://pubmed.ncbi.nlm.nih.gov/15028290/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP10-12,ENSG00000189169,Neither,14962103,Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21.,2004,10.1046/j.0022-202x.2003.22128.x,https://pubmed.ncbi.nlm.nih.gov/14962103/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP10-6,ENSG00000188155,Neither,35038288,Whole-exome sequencing reveals rare genetic variations in ovarian granulosa cell tumor.,2022,10.17305/bjbms.2021.6789,https://pubmed.ncbi.nlm.nih.gov/35038288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP10-6,ENSG00000188155,Neither,15028290,A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3.,2004,10.1016/j.ygeno.2003.09.024,https://pubmed.ncbi.nlm.nih.gov/15028290/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP10-6,ENSG00000188155,Neither,14962103,Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21.,2004,10.1046/j.0022-202x.2003.22128.x,https://pubmed.ncbi.nlm.nih.gov/14962103/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP12-4,ENSG00000212933,Neither,15028290,A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3.,2004,10.1016/j.ygeno.2003.09.024,https://pubmed.ncbi.nlm.nih.gov/15028290/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP12-4,ENSG00000212933,Neither,14962103,Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21.,2004,10.1046/j.0022-202x.2003.22128.x,https://pubmed.ncbi.nlm.nih.gov/14962103/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP13-1,ENSG00000198390,Neither,39409811,Characterisation of Three Ovine KRTAP13 Family Genes and Their Association with Wool Traits in Chinese Tan Sheep.,2024,10.3390/ani14192862,https://pubmed.ncbi.nlm.nih.gov/39409811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP13-1,ENSG00000198390,Neither,31275359,Chromosomal Localization of Candidate Genes for Fiber Growth and Color in Alpaca (Vicugna pacos).,2019,10.3389/fgene.2019.00583,https://pubmed.ncbi.nlm.nih.gov/31275359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP13-1,ENSG00000198390,Neither,33617351,Identifying and Validating Differentially Methylated Regions in Newly Diagnosed Patients with Graves' Disease.,2021,10.1089/dna.2020.6215,https://pubmed.ncbi.nlm.nih.gov/33617351/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP13-1,ENSG00000198390,Neither,12359730,Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1.,2002,10.1074/jbc.m206422200,https://pubmed.ncbi.nlm.nih.gov/12359730/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP20-1,ENSG00000244624,Neither,39202420,Effects of KRTAP20-1 Gene Variation on Wool Traits in Chinese Tan Sheep.,2024,10.3390/genes15081060,https://pubmed.ncbi.nlm.nih.gov/39202420/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP20-1,ENSG00000244624,Neither,30535023,Associations between variation in the ovine high glycine-tyrosine keratin-associated protein gene KRTAP20-1 and wool traits.,2019,10.1093/jas/sky465,https://pubmed.ncbi.nlm.nih.gov/30535023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP20-1,ENSG00000244624,Neither,31717789,"Characterisation of an Ovine Keratin Associated Protein (KAP) Gene, Which Would Produce a Protein Rich in Glycine and Tyrosine, but Lacking in Cysteine.",2019,10.3390/genes10110848,https://pubmed.ncbi.nlm.nih.gov/31717789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP20-2,ENSG00000184032,Neither,29149036,Identification of the Caprine Keratin-Associated Protein 20-2 (KAP20-2) Gene and Its Effect on Cashmere Traits.,2017,10.3390/genes8110328,https://pubmed.ncbi.nlm.nih.gov/29149036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP20-2,ENSG00000184032,Neither,34861880,Signature selection analysis reveals candidate genes associated with production traits in Iranian sheep breeds.,2021,10.1186/s12917-021-03077-4,https://pubmed.ncbi.nlm.nih.gov/34861880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP21-1,ENSG00000187005,Neither,41695674,Investigating RNA-Seq-based differential gene expression during hair follicle development in Angora goat skin.,2026,10.5187/jast.2024.e104,https://pubmed.ncbi.nlm.nih.gov/41695674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP21-1,ENSG00000187005,Neither,31315271,Identification of the Ovine Keratin-Associated Protein 21-1 Gene and Its Association with Variation in Wool Traits.,2019,10.3390/ani9070450,https://pubmed.ncbi.nlm.nih.gov/31315271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP21-2,ENSG00000187026,Neither,32019077,The Mean Staple Length of Wool Fibre Is Associated with Variation in the Ovine Keratin-Associated Protein 21-2 Gene.,2020,10.3390/genes11020148,https://pubmed.ncbi.nlm.nih.gov/32019077/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP6-1,ENSG00000184724,Neither,38254984,Spatiotemporal Expression Characterization of KRTAP6 Family Genes and Its Effect on Wool Traits.,2024,10.3390/genes15010095,https://pubmed.ncbi.nlm.nih.gov/38254984/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP6-1,ENSG00000184724,Neither,31807662,Variation in KRTAP6-1 affects wool fibre diameter in New Zealand Romney ewes.,2019,10.5194/aab-62-509-2019,https://pubmed.ncbi.nlm.nih.gov/31807662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP6-1,ENSG00000184724,Neither,19272529,Expression patterns of keratin intermediate filament and keratin associated protein genes in wool follicles.,2009,10.1016/j.diff.2008.10.009,https://pubmed.ncbi.nlm.nih.gov/19272529/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP6-1,ENSG00000184724,Neither,27045687,Identification of four new gene members of the KAP6 gene family in sheep.,2016,10.1038/srep24074,https://pubmed.ncbi.nlm.nih.gov/27045687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP6-1,ENSG00000184724,Neither,25279319,"The sheep KAP8-2 gene, a new KAP8 family member that is absent in humans.",2014,10.1186/2193-1801-3-528,https://pubmed.ncbi.nlm.nih.gov/25279319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,38792999,"Psoriasis and Psoriatic Arthritis-Associated Genes, Cytokines, and Human Leukocyte Antigens.",2024,10.3390/medicina60050815,https://pubmed.ncbi.nlm.nih.gov/38792999/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,34853291,Copy Number Variation Analysis of IL22 and LCE3C in Different Subtypes of Psoriasis in a Chinese Han Population.,2021,10.12659/msm.934927,https://pubmed.ncbi.nlm.nih.gov/34853291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,37805522,Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin.,2023,10.1038/s41467-023-41984-2,https://pubmed.ncbi.nlm.nih.gov/37805522/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,36299206,"[Screening, functional analysis and clinical validation of differentially expressed genes in diabetic foot ulcers].",2022,10.3760/cma.j.cn501225-20220731-00328,https://pubmed.ncbi.nlm.nih.gov/36299206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,36804407,CYSRT1: An Antimicrobial Epidermal Protein that Can Interact with Late Cornified Envelope Proteins.,2023,10.1016/j.jid.2023.01.022,https://pubmed.ncbi.nlm.nih.gov/36804407/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,34602061,Comprehensive RNA sequencing in primary murine keratinocytes and fibroblasts identifies novel biomarkers and provides potential therapeutic targets for skin-related diseases.,2021,10.1186/s11658-021-00285-6,https://pubmed.ncbi.nlm.nih.gov/34602061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,29401702,Bioactive Dietary VDR Ligands Regulate Genes Encoding Biomarkers of Skin Repair That Are Associated with Risk for Psoriasis.,2018,10.3390/nu10020174,https://pubmed.ncbi.nlm.nih.gov/29401702/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,27531006,Transcriptome sequencing of gingival biopsies from chronic periodontitis patients reveals novel gene expression and splicing patterns.,2016,10.1186/s40246-016-0084-0,https://pubmed.ncbi.nlm.nih.gov/27531006/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,34942199,Antimicrobial Late Cornified Envelope Proteins: The Psoriasis Risk Factor Deletion of LCE3B/C Genes Affects Microbiota Composition.,2022,10.1016/j.jid.2021.11.036,https://pubmed.ncbi.nlm.nih.gov/34942199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,34089377,Inhibition of dipeptidyl-peptidase 4 induces upregulation of the late cornified envelope cluster in keratinocytes.,2022,10.1007/s00403-021-02249-4,https://pubmed.ncbi.nlm.nih.gov/34089377/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,32075680,Maternal diabetes and obesity influence the fetal epigenome in a largely Hispanic population.,2020,10.1186/s13148-020-0824-9,https://pubmed.ncbi.nlm.nih.gov/32075680/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,27048876,Increased Risk of Psoriasis due to combined effect of HLA-Cw6 and LCE3 risk alleles in Indian population.,2016,10.1038/srep24059,https://pubmed.ncbi.nlm.nih.gov/27048876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,34409462,A transcriptome-wide association study identifies novel susceptibility genes for psoriasis.,2021,10.1093/hmg/ddab237,https://pubmed.ncbi.nlm.nih.gov/34409462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,29055413,Pushing the Envelope in Psoriasis: Late Cornified Envelope Proteins Possess Antimicrobial Activity.,2017,10.1016/j.jid.2017.08.026,https://pubmed.ncbi.nlm.nih.gov/29055413/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,28634035,Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have Antibacterial Activity.,2017,10.1016/j.jid.2017.06.003,https://pubmed.ncbi.nlm.nih.gov/28634035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,27919236,The psoriasis-associated deletion of late cornified envelope genes LCE3B and LCE3C has been maintained under balancing selection since Human Denisovan divergence.,2016,10.1186/s12862-016-0842-6,https://pubmed.ncbi.nlm.nih.gov/27919236/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,27766957,Copy number variations in Saudi family with intellectual disability and epilepsy.,2016,10.1186/s12864-016-3091-6,https://pubmed.ncbi.nlm.nih.gov/27766957/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,32596344,Identification of 5 Gene Signatures in Survival Prediction for Patients with Lung Squamous Cell Carcinoma Based on Integrated Multiomics Data Analysis.,2020,10.1155/2020/6427483,https://pubmed.ncbi.nlm.nih.gov/32596344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,20331852,Mutation analysis of the LCE3B/LCE3C genes in Psoriasis.,2010,10.1186/1471-2350-11-45,https://pubmed.ncbi.nlm.nih.gov/20331852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,27376048,Feasibility of establishing deletion of the late cornified envelope genes LCE3B and LCE3C as a susceptibility factor for psoriasis.,2016,10.4103/2277-9175.183670,https://pubmed.ncbi.nlm.nih.gov/27376048/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,26626624,Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.,2015,10.1016/j.ajhg.2015.10.019,https://pubmed.ncbi.nlm.nih.gov/26626624/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE3C,ENSG00000244057,Neither,15854049,Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.,2005,10.1111/j.0022-202x.2005.23699.x,https://pubmed.ncbi.nlm.nih.gov/15854049/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,42274594,Lim Homeobox 8 Is Essential for Beta Adrenergic Stimulation of Thermogenesis in Human Adipocytes.,2026,10.3390/cells15111000,https://pubmed.ncbi.nlm.nih.gov/42274594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,41349606,Modulation of the tumor microenvironment through BMAL1-LHX8 axis augments the sensitivity of ameloblastoma to vemurafenib.,2026,10.1016/j.jare.2025.11.069,https://pubmed.ncbi.nlm.nih.gov/41349606/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,42815329,Prenatal PM&lt;sub&gt;2.5&lt;/sub&gt; exposure disrupts cortical excitatory/inhibitory balance in male offspring by suppressing Lhx8-regulated cholinergic homeostasis and cell adhesion.,2026,10.1016/j.ecoenv.2026.120862,https://pubmed.ncbi.nlm.nih.gov/42815329/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,41566502,Novel LHX8 variants associated with distinctive oocyte morphological abnormalities and maturation arrest in primary infertility.,2026,10.1186/s13048-026-01978-2,https://pubmed.ncbi.nlm.nih.gov/41566502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,41820501,Clinical performance of ASCL1/LHX8 DNA methylation on first-void urine to screen for cervical cancer.,2026,10.1038/s43856-026-01512-x,https://pubmed.ncbi.nlm.nih.gov/41820501/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,42587731,&lt;i&gt;FAM153A&lt;/i&gt; Is a Novel Biomarker of Human Thermogenic Adipocytes.,2026,10.3390/cells15151321,https://pubmed.ncbi.nlm.nih.gov/42587731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,40670092,FOXO1 Targets LHX8 to Promote Granulosa Cell Apoptosis.,2026,10.1620/tjem.2025.j093,https://pubmed.ncbi.nlm.nih.gov/40670092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,42346084,"Cholinergic Differentiation of Human iPSCs Reveals Early APOE4-Driven Dysregulation of Neuronal Markers, Synaptogenesis and Inflammatory Responses.",2026,10.3390/cells15121057,https://pubmed.ncbi.nlm.nih.gov/42346084/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,41957618,Evaluating DNA methylation markers and extended HPV genotyping in first-void urine for detecting high-grade cervical lesions in HPV-positive women: a cross-sectional study.,2026,10.1186/s12916-026-04837-5,https://pubmed.ncbi.nlm.nih.gov/41957618/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,41216763,Disruption of ovarian function and induction of apoptosis in female mice by Brefeldin A: Mechanistic insights into reproductive toxicity.,2025,10.1002/ame2.70102,https://pubmed.ncbi.nlm.nih.gov/41216763/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,42392486,Multiplex methylation marker analysis for ctDNA detection in liquid biopsies from anal cancer patients: an HPV-independent approach.,2027,10.1016/j.cca.2026.121206,https://pubmed.ncbi.nlm.nih.gov/42392486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,41075272,Genetic heterogeneity and homogeneity among orofacial cleft subtypes: genome-wide association studies in the cleft collective.,2025,10.1093/hmg/ddaf131,https://pubmed.ncbi.nlm.nih.gov/41075272/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,41678079,Wharton's jelly-derived mesenchymal stem cells promote the survival and early development of pre-antral follicles.,2026,10.1007/s10815-026-03827-z,https://pubmed.ncbi.nlm.nih.gov/41678079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,37809754,Mir-142-5p inhibits the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting Lhx8.,2023,10.1016/j.heliyon.2023.e19878,https://pubmed.ncbi.nlm.nih.gov/37809754/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,38703583,LIM homeobox 8 reduced apoptosis and promoted periodontal tissue regeneration function of dental pulp stem cells.,2024,10.1016/j.tice.2024.102387,https://pubmed.ncbi.nlm.nih.gov/38703583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,39732776,Whole genome sequencing reveals candidate causal genetic variants for spastic syndrome in Holstein cattle.,2024,10.1038/s41598-024-82446-z,https://pubmed.ncbi.nlm.nih.gov/39732776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,37194006,Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice.,2023,10.1186/s12958-023-01097-3,https://pubmed.ncbi.nlm.nih.gov/37194006/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,37642817,Gene expression and demographic analyses in women with the poor ovarian response: a computational approach.,2023,10.1007/s10815-023-02919-4,https://pubmed.ncbi.nlm.nih.gov/37642817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,38181927,L-carnitine fails to rescue chemotherapy injured ovaries by epigenetic changes of transcription factors.,2024,10.1016/j.gene.2024.148128,https://pubmed.ncbi.nlm.nih.gov/38181927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,41595467,Transcriptomic Profiling Reveals Biphasic Regulatory Instability and Late-Stage Proteostatic Decline in Aging Mouse Oocytese.,2025,10.3390/genes17010047,https://pubmed.ncbi.nlm.nih.gov/41595467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,40945664,Prenatal BPB/BPAF exposure induces depression-like behavior in male mice offspring via compound-specific transcriptional dysregulation and neurodevelopmental pathway alterations.,2025,10.1016/j.neuro.2025.103322,https://pubmed.ncbi.nlm.nih.gov/40945664/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,39686532,Colposcopy referrals and CIN3 detection after triage by host cell DNA methylation and/or HPV genotyping in HPV positive women with low-grade cytology from a population-based Dutch primary HPV screening trial.,2025,10.1002/ijc.35289,https://pubmed.ncbi.nlm.nih.gov/39686532/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,36366827,Validation of ASCL1 and LHX8 Methylation Analysis as Primary Cervical Cancer Screening Strategy in South African Women with Human Immunodeficiency Virus.,2023,10.1093/cid/ciac801,https://pubmed.ncbi.nlm.nih.gov/36366827/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,39471050,Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort.,2025,10.1097/j.pain.0000000000003463,https://pubmed.ncbi.nlm.nih.gov/39471050/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,37100874,Evaluation of DNA methylation biomarkers ASCL1 and LHX8 on HPV-positive self-collected samples from primary HPV-based screening.,2023,10.1038/s41416-023-02277-z,https://pubmed.ncbi.nlm.nih.gov/37100874/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,41275248,Clinical validation of a three-marker methylation panel to detect CIN3+ in vaginal self-samples in the Dutch population-based screening programme.,2025,10.1186/s13148-025-02020-w,https://pubmed.ncbi.nlm.nih.gov/41275248/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,39849206,Rapid human oogonia-like cell specification via transcription factor-directed differentiation.,2025,10.1038/s44319-025-00371-2,https://pubmed.ncbi.nlm.nih.gov/39849206/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,34112263,Temporal induction of Lhx8 by optogenetic control system for efficient bone regeneration.,2021,10.1186/s13287-021-02412-8,https://pubmed.ncbi.nlm.nih.gov/34112263/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,37889105,Cyanidin-3-O-glucoside Mitigates the Ovarian Defect Induced by Zearalenone via p53-GADD45a Signaling during Primordial Follicle Assembly.,2023,10.1021/acs.jafc.3c03315,https://pubmed.ncbi.nlm.nih.gov/37889105/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,34558659,"Performance of DNA methylation analysis of ASCL1, LHX8, ST6GALNAC5, GHSR, ZIC1 and SST for the triage of HPV-positive women: Results from a Dutch primary HPV-based screening cohort.",2022,10.1002/ijc.33820,https://pubmed.ncbi.nlm.nih.gov/34558659/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,38008054,Melatonin alleviates the toxic effect of di(2-ethylhexyl) phthalate on oocyte quality resulting from CEBPB suppression during primordial follicle formation.,2024,10.1016/j.jhazmat.2023.132997,https://pubmed.ncbi.nlm.nih.gov/38008054/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,38593938,Perinatal bisphenol S exposure exacerbates the oxidative burden and apoptosis in neonatal ovaries by suppressing the mTOR/autophagy axis.,2024,10.1016/j.envpol.2024.123939,https://pubmed.ncbi.nlm.nih.gov/38593938/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,36602025,Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8.,2023,10.7554/elife.78421,https://pubmed.ncbi.nlm.nih.gov/36602025/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX8,ENSG00000162624,Neither,31754390,Optogenetic control of mesenchymal cell fate towards precise bone regeneration.,2019,10.7150/thno.36455,https://pubmed.ncbi.nlm.nih.gov/31754390/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPJ,ENSG00000204022,Neither,42806811,"Krüppel-like factors regulate lipid homeostasis to modulate SKN-1/Nrf activity, oxidative stress resistance and longevity.",2026,10.1093/genetics/iyag255,https://pubmed.ncbi.nlm.nih.gov/42806811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPJ,ENSG00000204022,Neither,40282741,Valorization of Citrus Peel Byproducts: A Sustainable Approach to Nutrient-Rich Jam Production.,2025,10.3390/foods14081339,https://pubmed.ncbi.nlm.nih.gov/40282741/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPJ,ENSG00000204022,Neither,30696079,Determination of Genetic Effects of LIPK and LIPJ Genes on Milk Fatty Acids in Dairy Cattle.,2019,10.3390/genes10020086,https://pubmed.ncbi.nlm.nih.gov/30696079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPJ,ENSG00000204022,Neither,36698149,Lipolysis and gestational diabetes mellitus onset: a case-cohort genome-wide association study in Chinese.,2023,10.1186/s12967-023-03902-4,https://pubmed.ncbi.nlm.nih.gov/36698149/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPJ,ENSG00000204022,Neither,28742841,Bacillus sp. JR3 esterase LipJ: A new mesophilic enzyme showing traces of a thermophilic past.,2017,10.1371/journal.pone.0181029,https://pubmed.ncbi.nlm.nih.gov/28742841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPJ,ENSG00000204022,Neither,27083848,Point mutation Gln121-Arg increased temperature optima of Bacillus lipase (1.4 subfamily) by fifteen degrees.,2016,10.1016/j.ijbiomac.2016.04.022,https://pubmed.ncbi.nlm.nih.gov/27083848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPJ,ENSG00000204022,Neither,25116855,Redox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparum.,2014,10.1111/mmi.12753,https://pubmed.ncbi.nlm.nih.gov/25116855/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPJ,ENSG00000204022,Neither,28543853,"Crystal structure of lipoate-bound lipoate ligase 1, LipL1, from Plasmodium falciparum.",2017,10.1002/prot.25324,https://pubmed.ncbi.nlm.nih.gov/28543853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPJ,ENSG00000204022,Neither,20598663,Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo).,2010,10.1016/j.cbd.2010.05.004,https://pubmed.ncbi.nlm.nih.gov/20598663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPJ,ENSG00000204022,Neither,26927997,Use of an adipocyte model to study the transcriptional adaptation of Mycobacterium tuberculosis to store and degrade host fat.,2016,10.1016/j.ijmyco.2015.10.003,https://pubmed.ncbi.nlm.nih.gov/26927997/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPJ,ENSG00000204022,Neither,17244193,Scavenging of the cofactor lipoate is essential for the survival of the malaria parasite Plasmodium falciparum.,2007,10.1111/j.1365-2958.2007.05592.x,https://pubmed.ncbi.nlm.nih.gov/17244193/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPJ,ENSG00000204022,Neither,24858810,Genome wide association study identifies 20 novel promising genes associated with milk fatty acid traits in Chinese Holstein.,2014,10.1371/journal.pone.0096186,https://pubmed.ncbi.nlm.nih.gov/24858810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPJ,ENSG00000204022,Neither,14687214,Molecular approach for analysis of model fungal genes encoding ligninolytic peroxidases in wood-decaying soil systems.,2004,10.1046/j.1472-765x.2003.01442.x,https://pubmed.ncbi.nlm.nih.gov/14687214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPJ,ENSG00000204022,Neither,10348854,Organization and differential regulation of a cluster of lignin peroxidase genes of Phanerochaete chrysosporium.,1999,10.1128/jb.181.11.3427-3432.1999,https://pubmed.ncbi.nlm.nih.gov/10348854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LITAFD,ENSG00000283516,Neither,34696794,Equine vitiligo-like depigmentation in grey horses is related to genes involved in immune response and tumor metastasis.,2021,10.1186/s12917-021-03046-x,https://pubmed.ncbi.nlm.nih.gov/34696794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC72,ENSG00000205858,Neither,38612805,Proteomic Analyses Reveal the Role of Alpha-2-Macroglobulin in Canine Osteosarcoma Cell Migration.,2024,10.3390/ijms25073989,https://pubmed.ncbi.nlm.nih.gov/38612805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC74A,ENSG00000100565,Neither,28356075,Genome-wide association study and accuracy of genomic prediction for teat number in Duroc pigs using genotyping-by-sequencing.,2017,10.1186/s12711-017-0311-8,https://pubmed.ncbi.nlm.nih.gov/28356075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRIQ4,ENSG00000188306,Neither,34685603,Terc Gene Cluster Variants Predict Liver Telomere Length in Mice.,2021,10.3390/cells10102623,https://pubmed.ncbi.nlm.nih.gov/34685603/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRIQ4,ENSG00000188306,Neither,22532330,"LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication.",2012,10.1002/bies.201100173,https://pubmed.ncbi.nlm.nih.gov/22532330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,39801191,Overexpression of MAGE-A2 is Related to the Malignant Degree and Progression of Disease in Patients With Clear Cell Renal Cell Carcinoma.,2025,10.1097/pai.0000000000001243,https://pubmed.ncbi.nlm.nih.gov/39801191/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,41387877,Tumor immune microenvironment score predicts efficacy of immune checkpoint inhibitors-based regimens in advanced non-small cell lung cancer.,2025,10.1186/s12967-025-07408-z,https://pubmed.ncbi.nlm.nih.gov/41387877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,41799830,The deubiquitinase OTULIN regulates tau expression and RNA metabolism in neurons.,2025,10.61373/gp025a.0116,https://pubmed.ncbi.nlm.nih.gov/41799830/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,37951911,Development of dendritic cell loaded MAGE-A2 long peptide; a potential target for tumor-specific T cell-mediated prostate cancer immunotherapy.,2023,10.1186/s12935-023-03108-0,https://pubmed.ncbi.nlm.nih.gov/37951911/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,34837545,Overexpression of melanoma-associated antigen A2 has a clinical significance in embryonal carcinoma and is associated with tumor progression.,2022,10.1007/s00432-021-03859-1,https://pubmed.ncbi.nlm.nih.gov/34837545/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,39605116,hMAGEA2 as a potential diagnostic and therapeutic target for melanoma progression and metastasis.,2024,10.14715/cmb/2024.70.10.14,https://pubmed.ncbi.nlm.nih.gov/39605116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,37814317,Immunization with a multi-antigen targeted DNA vaccine eliminates chemoresistant pancreatic cancer by disrupting tumor-stromal cell crosstalk.,2023,10.1186/s12967-023-04519-3,https://pubmed.ncbi.nlm.nih.gov/37814317/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,32772147,Reduced cytoplasmic expression of MAGE-A2 predicts tumor aggressiveness and survival: an immunohistochemical analysis.,2021,10.1007/s00345-020-03395-6,https://pubmed.ncbi.nlm.nih.gov/32772147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,30064232,Melanoma-associated antigen A2 is overexpressed in glioma and associated with poor prognosis in glioma patients.,2018,10.4149/neo_2018_170625n440,https://pubmed.ncbi.nlm.nih.gov/30064232/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,32065444,"Inhibition of MAGEA2 regulates pluripotency, proliferation, apoptosis, and differentiation in mouse embryonic stem cells.",2020,10.1002/jcb.29692,https://pubmed.ncbi.nlm.nih.gov/32065444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,32701706,Differential Expression of Cancer Testis Antigens on Lentigo Maligna and Lentigo Maligna Melanoma.,2020,10.1097/dad.0000000000001607,https://pubmed.ncbi.nlm.nih.gov/32701706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,30006881,Specific Features of Transcription Activity of Cancer-Testis Antigens in Patients with Metastatic and Non-Metastatic Breast Cancer.,2018,10.1007/s10517-018-4175-x,https://pubmed.ncbi.nlm.nih.gov/30006881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,30615012,Expression of cancer/testis antigens in cutaneous melanoma: a systematic review.,2019,10.1097/cmr.0000000000000569,https://pubmed.ncbi.nlm.nih.gov/30615012/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,32149050,Identification of key genes and pathways in gastric signet ring cell carcinoma based on transcriptome analysis.,2020,10.12998/wjcc.v8.i4.658,https://pubmed.ncbi.nlm.nih.gov/32149050/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,31143371,Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells.,2019,10.18632/oncotarget.26933,https://pubmed.ncbi.nlm.nih.gov/31143371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,32626651,Methylation Profile of X-Chromosome-Related Genes in Male Breast Cancer.,2020,10.3389/fonc.2020.00784,https://pubmed.ncbi.nlm.nih.gov/32626651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,28498455,Overexpression of MAGEA2 has a prognostic significance and is a potential therapeutic target for patients with lung cancer.,2017,10.3892/ijo.2017.3984,https://pubmed.ncbi.nlm.nih.gov/28498455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,31059106,Signature microRNAs and long noncoding RNAs in laryngeal cancer recurrence identified using a competing endogenous RNA network.,2019,10.3892/mmr.2019.10143,https://pubmed.ncbi.nlm.nih.gov/31059106/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,26001071,MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4.,2015,10.1371/journal.pone.0127713,https://pubmed.ncbi.nlm.nih.gov/26001071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,33906667,Significant abnormal glycemic variability increased the risk for arrhythmias in elderly type 2 diabetic patients.,2021,10.1186/s12902-021-00753-2,https://pubmed.ncbi.nlm.nih.gov/33906667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,27323861,Expression of tumor antigens on primary ovarian cancer cells compared to established ovarian cancer cell lines.,2016,10.18632/oncotarget.10028,https://pubmed.ncbi.nlm.nih.gov/27323861/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,22895835,Dendritic cell-based vaccination in metastatic melanoma patients: phase II clinical trial.,2012,10.3892/or.2012.1956,https://pubmed.ncbi.nlm.nih.gov/22895835/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,28263240,Peptide-pulsed dendritic cell vaccine in combination with carboplatin and paclitaxel chemotherapy for stage IV melanoma.,2017,10.1097/cmr.0000000000000342,https://pubmed.ncbi.nlm.nih.gov/28263240/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,24662835,Identification of MAGEA antigens as causal players in the development of tamoxifen-resistant breast cancer.,2014,10.1038/onc.2014.45,https://pubmed.ncbi.nlm.nih.gov/24662835/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,21149604,A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer.,2011,10.4049/jimmunol.1001775,https://pubmed.ncbi.nlm.nih.gov/21149604/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,22117195,MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs.,2012,10.1038/cdd.2011.173,https://pubmed.ncbi.nlm.nih.gov/22117195/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,25123082,Low-dose decitabine induces MAGE-A expression and inhibits invasion via suppression of NF-κB2 and MMP2 in Eca109 cells.,2014,10.1016/j.biopha.2014.07.013,https://pubmed.ncbi.nlm.nih.gov/25123082/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,19144076,"Induction of multiepitopic and long-lasting immune responses against tumour antigens by immunization with peptides, DNA and recombinant adenoviruses expressing minigenes.",2009,10.1111/j.1365-3083.2008.02202.x,https://pubmed.ncbi.nlm.nih.gov/19144076/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,21558405,"BORIS binding to the promoters of cancer testis antigens, MAGEA2, MAGEA3, and MAGEA4, is associated with their transcriptional activation in lung cancer.",2011,10.1158/1078-0432.ccr-11-0653,https://pubmed.ncbi.nlm.nih.gov/21558405/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,23138873,"Immunomodulatory activity of SGI-110, a 5-aza-2'-deoxycytidine-containing demethylating dinucleotide.",2013,10.1007/s00262-012-1365-7,https://pubmed.ncbi.nlm.nih.gov/23138873/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2,ENSG00000268606,Neither,26820613,Expression of MAGE-A1-A12 subgroups in the invasive tumor front and tumor center in oral squamous cell carcinoma.,2016,10.3892/or.2016.4600,https://pubmed.ncbi.nlm.nih.gov/26820613/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,41387877,Tumor immune microenvironment score predicts efficacy of immune checkpoint inhibitors-based regimens in advanced non-small cell lung cancer.,2025,10.1186/s12967-025-07408-z,https://pubmed.ncbi.nlm.nih.gov/41387877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,39605116,hMAGEA2 as a potential diagnostic and therapeutic target for melanoma progression and metastasis.,2024,10.14715/cmb/2024.70.10.14,https://pubmed.ncbi.nlm.nih.gov/39605116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,37814317,Immunization with a multi-antigen targeted DNA vaccine eliminates chemoresistant pancreatic cancer by disrupting tumor-stromal cell crosstalk.,2023,10.1186/s12967-023-04519-3,https://pubmed.ncbi.nlm.nih.gov/37814317/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,32149050,Identification of key genes and pathways in gastric signet ring cell carcinoma based on transcriptome analysis.,2020,10.12998/wjcc.v8.i4.658,https://pubmed.ncbi.nlm.nih.gov/32149050/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,32065444,"Inhibition of MAGEA2 regulates pluripotency, proliferation, apoptosis, and differentiation in mouse embryonic stem cells.",2020,10.1002/jcb.29692,https://pubmed.ncbi.nlm.nih.gov/32065444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,30064232,Melanoma-associated antigen A2 is overexpressed in glioma and associated with poor prognosis in glioma patients.,2018,10.4149/neo_2018_170625n440,https://pubmed.ncbi.nlm.nih.gov/30064232/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,30006881,Specific Features of Transcription Activity of Cancer-Testis Antigens in Patients with Metastatic and Non-Metastatic Breast Cancer.,2018,10.1007/s10517-018-4175-x,https://pubmed.ncbi.nlm.nih.gov/30006881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,37535601,"TGM2, HMGA2, FXYD3, and LGALS4 genes as biomarkers in acquired oxaliplatin resistance of human colorectal cancer: A systems biology approach.",2023,10.1371/journal.pone.0289535,https://pubmed.ncbi.nlm.nih.gov/37535601/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,32626651,Methylation Profile of X-Chromosome-Related Genes in Male Breast Cancer.,2020,10.3389/fonc.2020.00784,https://pubmed.ncbi.nlm.nih.gov/32626651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,28498455,Overexpression of MAGEA2 has a prognostic significance and is a potential therapeutic target for patients with lung cancer.,2017,10.3892/ijo.2017.3984,https://pubmed.ncbi.nlm.nih.gov/28498455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,31059106,Signature microRNAs and long noncoding RNAs in laryngeal cancer recurrence identified using a competing endogenous RNA network.,2019,10.3892/mmr.2019.10143,https://pubmed.ncbi.nlm.nih.gov/31059106/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,33906667,Significant abnormal glycemic variability increased the risk for arrhythmias in elderly type 2 diabetic patients.,2021,10.1186/s12902-021-00753-2,https://pubmed.ncbi.nlm.nih.gov/33906667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,21422315,The role of MAGEA2 in head and neck cancer.,2011,10.1001/archoto.2011.2,https://pubmed.ncbi.nlm.nih.gov/21422315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,27226137,The Magea gene cluster regulates male germ cell apoptosis without affecting the fertility in mice.,2016,10.1038/srep26735,https://pubmed.ncbi.nlm.nih.gov/27226137/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,28342986,Oncogenic roles of DNA hypomethylation through the activation of cancer-germline genes.,2017,10.1016/j.canlet.2017.03.029,https://pubmed.ncbi.nlm.nih.gov/28342986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,24662835,Identification of MAGEA antigens as causal players in the development of tamoxifen-resistant breast cancer.,2014,10.1038/onc.2014.45,https://pubmed.ncbi.nlm.nih.gov/24662835/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,28415749,hMAGEA2 promotes progression of breast cancer by regulating Akt and Erk1/2 pathways.,2017,10.18632/oncotarget.16184,https://pubmed.ncbi.nlm.nih.gov/28415749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,24481586,"The adherens junction-associated protein 1 is a negative transcriptional regulator of MAGEA2, which potentiates temozolomide-induced apoptosis in GBM.",2014,10.3892/ijo.2014.2277,https://pubmed.ncbi.nlm.nih.gov/24481586/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,21558405,"BORIS binding to the promoters of cancer testis antigens, MAGEA2, MAGEA3, and MAGEA4, is associated with their transcriptional activation in lung cancer.",2011,10.1158/1078-0432.ccr-11-0653,https://pubmed.ncbi.nlm.nih.gov/21558405/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,22117195,MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs.,2012,10.1038/cdd.2011.173,https://pubmed.ncbi.nlm.nih.gov/22117195/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,19144076,"Induction of multiepitopic and long-lasting immune responses against tumour antigens by immunization with peptides, DNA and recombinant adenoviruses expressing minigenes.",2009,10.1111/j.1365-3083.2008.02202.x,https://pubmed.ncbi.nlm.nih.gov/19144076/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,17509725,Immunization of NSCLC patients with antigen-pulsed immature autologous dendritic cells.,2007,10.1016/j.lungcan.2007.04.002,https://pubmed.ncbi.nlm.nih.gov/17509725/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,18237105,Prognostic impact of cancer/testis antigen expression in advanced stage multiple myeloma patients.,2008,,https://pubmed.ncbi.nlm.nih.gov/18237105/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,23574628,"Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene.",2013,10.1111/tan.12113,https://pubmed.ncbi.nlm.nih.gov/23574628/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,25320011,Combined genome and transcriptome analysis of single disseminated cancer cells from bone marrow of prostate cancer patients reveals unexpected transcriptomes.,2014,10.1158/0008-5472.can-14-0934,https://pubmed.ncbi.nlm.nih.gov/25320011/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,12855658,Overexpression of MAGE/GAGE genes in paclitaxel/doxorubicin-resistant human cancer cell lines.,2003,,https://pubmed.ncbi.nlm.nih.gov/12855658/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,15160996,Cytotoxic T cell induction against human malignant melanoma cells using HLA-A24-restricted melanoma peptide cocktail.,2004,,https://pubmed.ncbi.nlm.nih.gov/15160996/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,11924907,"Promoter methylation controls the expression of MAGE2, 3 and 4 genes in human cutaneous melanoma.",2002,10.1097/00002371-200201000-00002,https://pubmed.ncbi.nlm.nih.gov/11924907/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,15355897,Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants.,2004,10.1158/1078-0432.ccr-04-0468,https://pubmed.ncbi.nlm.nih.gov/15355897/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,9544234,The multi-epitope approach for immunotherapy for cancer: identification of several CTL epitopes from various tumor-associated antigens expressed on solid epithelial tumors.,1998,10.1016/s0198-8859(97)00255-3,https://pubmed.ncbi.nlm.nih.gov/9544234/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA2B,ENSG00000183305,Neither,15254048,Autologous dendritic cell vaccines for non-small-cell lung cancer.,2004,10.1200/jco.2004.01.074,https://pubmed.ncbi.nlm.nih.gov/15254048/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,39979188,"MAGEA9 Expression in Vocal Fold Leukoplakia and Its Enhancement of Vocal Fold Leukoplakia Epithelial Cell Proliferation, Migration, and Invasion Through the NF-kB-MMP-2/9 Pathway.",2025,10.1016/j.jvoice.2025.02.001,https://pubmed.ncbi.nlm.nih.gov/39979188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,40791813,DNA-demethylation by DAC induces &lt;i&gt;MAGE&lt;/i&gt; expression and MAGE-specific T cell reactivity against tumors but also healthy cell subsets.,2025,10.1016/j.omton.2025.201018,https://pubmed.ncbi.nlm.nih.gov/40791813/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,41489697,Serum cancer testis antigen MAGEA3-IgG serves as a diagnostic biomarker in lung adenocarcinoma.,2026,10.1007/s12094-025-04173-9,https://pubmed.ncbi.nlm.nih.gov/41489697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,39082035,Expression pattern analysis of the MAGE family genes in breast cancer patients and hypomethylation activation in the MCF-7 cells.,2024,10.1016/j.heliyon.2024.e34506,https://pubmed.ncbi.nlm.nih.gov/39082035/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,39224047,Brief Communication on MAGE-A4 and Coexpression of Cancer Testis Antigens in Metastatic Synovial Sarcomas: Considerations for Development of Immunotherapeutics.,2025,10.1097/cji.0000000000000541,https://pubmed.ncbi.nlm.nih.gov/39224047/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,35794903,Analysis of the Clinical Value of MAGE-A9 Expressions in Cervical Cancer Tissues and PBMC.,2022,10.1155/2022/1417752,https://pubmed.ncbi.nlm.nih.gov/35794903/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,38285780,Expression of MAGE A1 to MAGE A10 in the Forceps Biopsy and Bronchoalveolar Lavage Specimens from Patients with the Central Lung Tumor.,2024,10.31557/apjcp.2024.25.1.159,https://pubmed.ncbi.nlm.nih.gov/38285780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,36589698,A library of cancer testis specific T cell receptors for T cell receptor gene therapy.,2023,10.1016/j.omto.2022.11.007,https://pubmed.ncbi.nlm.nih.gov/36589698/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,34885041,Proteomic Signatures of Diffuse and Intestinal Subtypes of Gastric Cancer.,2021,10.3390/cancers13235930,https://pubmed.ncbi.nlm.nih.gov/34885041/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,28927095,High expression of MAGE-A9 is associated with unfavorable survival in esophageal squamous cell carcinoma.,2017,10.3892/ol.2017.6614,https://pubmed.ncbi.nlm.nih.gov/28927095/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,32879299,Long Non-Coding RNA (lncRNA) Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes Cell Proliferation and Migration by Regulating miR-143-3p and MAGE Family Member A9 (MAGEA9) in Oral Squamous Cell Carcinoma.,2020,10.12659/msm.924187,https://pubmed.ncbi.nlm.nih.gov/32879299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,29556384,MAGE-A9 in head and neck cancer: Prognostic value and preclinical findings in the context of irradiation.,2018,10.3892/mco.2018.1558,https://pubmed.ncbi.nlm.nih.gov/29556384/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,25755744,High expression of MAGE-A9 in tumor and stromal cells of non-small cell lung cancer was correlated with patient poor survival.,2015,,https://pubmed.ncbi.nlm.nih.gov/25755744/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,26175056,Overexpression of MAGE-A9 Is Predictive of Poor Prognosis in Epithelial Ovarian Cancer.,2015,10.1038/srep12104,https://pubmed.ncbi.nlm.nih.gov/26175056/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,29138811,High expression of MAGE-A9 contributes to stemness and malignancy of human hepatocellular carcinoma.,2018,10.3892/ijo.2017.4198,https://pubmed.ncbi.nlm.nih.gov/29138811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,26516058,Prognostic value of MAGE-A9 expression in patients with colorectal cancer.,2016,10.1016/j.clinre.2015.08.005,https://pubmed.ncbi.nlm.nih.gov/26516058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,26717042,High expression levels of MAGE-A9 are correlated with unfavorable survival in lung adenocarcinoma.,2016,10.18632/oncotarget.6741,https://pubmed.ncbi.nlm.nih.gov/26717042/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,30302801,"MiR-143-3p suppresses cell proliferation, migration, and invasion by targeting Melanoma-Associated Antigen A9 in laryngeal squamous cell carcinoma.",2019,10.1002/jcb.27084,https://pubmed.ncbi.nlm.nih.gov/30302801/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,25400753,Expression and prognostic value of MAGE-A9 in laryngeal squamous cell carcinoma.,2014,,https://pubmed.ncbi.nlm.nih.gov/25400753/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,25315972,High expression of MAGE-A9 correlates with unfavorable survival in hepatocellular carcinoma.,2014,10.1038/srep06625,https://pubmed.ncbi.nlm.nih.gov/25315972/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,26766421,"Expression of MAGE-A1, -A9, -A11 in laryngeal squamous cell carcinoma and their prognostic significance: a retrospective clinical study.",2016,10.3109/00016489.2015.1126856,https://pubmed.ncbi.nlm.nih.gov/26766421/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,31124967,Analysis of the function of MAGE-A in esophageal carcinoma by bioinformatics.,2019,10.1097/md.0000000000015774,https://pubmed.ncbi.nlm.nih.gov/31124967/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,31407331,Patterns of antibody responses to nonviral cancer antigens in head and neck squamous cell carcinoma patients differ by human papillomavirus status.,2019,10.1002/ijc.32623,https://pubmed.ncbi.nlm.nih.gov/31407331/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,23377668,Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy.,2013,10.1097/cji.0b013e3182829903,https://pubmed.ncbi.nlm.nih.gov/23377668/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,19533752,High frequency of MAGE-A4 and MAGE-A9 expression in high-risk bladder cancer.,2009,10.1002/ijc.24503,https://pubmed.ncbi.nlm.nih.gov/19533752/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,20548033,Concomitant tumor and autoantigen vaccination supports renal cell carcinoma rejection.,2010,10.4049/jimmunol.0902683,https://pubmed.ncbi.nlm.nih.gov/20548033/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,24777966,Spontaneous peripheral T-cell responses toward the tumor-associated antigen cyclin D1 in patients with clear cell renal cell carcinoma.,2013,10.1158/2326-6066.cir-13-0113,https://pubmed.ncbi.nlm.nih.gov/24777966/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA9,ENSG00000123584,Neither,25123082,Low-dose decitabine induces MAGE-A expression and inhibits invasion via suppression of NF-κB2 and MMP2 in Eca109 cells.,2014,10.1016/j.biopha.2014.07.013,https://pubmed.ncbi.nlm.nih.gov/25123082/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB10,ENSG00000177689,Neither,42121790,A Novel Recombinant MAGE-B10-HSP110 Fusion Protein Enhances Innate and Adaptive Immune Responses in Mice: A Potential Vaccine Candidate for Canine Mammary Tumors.,2026,10.3390/ani16091374,https://pubmed.ncbi.nlm.nih.gov/42121790/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB10,ENSG00000177689,Neither,40218304,"Preliminary Exploration of &lt;i&gt;MAGE-B1&lt;/i&gt;, &lt;i&gt;-B4&lt;/i&gt;, &lt;i&gt;-B5&lt;/i&gt;, and &lt;i&gt;-B10&lt;/i&gt; mRNA Expression in Canine Mammary Tumors in Dogs.",2025,10.3390/ani15070910,https://pubmed.ncbi.nlm.nih.gov/40218304/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB10,ENSG00000177689,Neither,34307667,Trophinin Is an Important Biomarker and Prognostic Factor in Osteosarcoma: Data Mining from Oncomine and the Cancer Genome Atlas Databases.,2021,10.1155/2021/6885897,https://pubmed.ncbi.nlm.nih.gov/34307667/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB16,ENSG00000189023,Neither,41988164,MAGEB16 as an epigenetic timing regulator linking X-chromosome biology to neurodevelopmental vulnerability in Autism Spectrum Disorder.,2026,10.17179/excli2026-9338,https://pubmed.ncbi.nlm.nih.gov/41988164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB16,ENSG00000189023,Neither,40117938,Knockdown of Mageb16 disrupts cell proliferation and lineage specification during mouse preimplantation development.,2025,10.1016/j.theriogenology.2025.117391,https://pubmed.ncbi.nlm.nih.gov/40117938/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB16,ENSG00000189023,Neither,29079788,Depletion of Mageb16 induces differentiation of pluripotent stem cells predominantly into mesodermal derivatives.,2017,10.1038/s41598-017-14561-z,https://pubmed.ncbi.nlm.nih.gov/29079788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB16,ENSG00000189023,Neither,24219866,Demethylation of CpG islands in the 5' upstream regions mediates the expression of the human testis-specific gene MAGEB16 and its mouse homolog Mageb16.,2014,10.5483/bmbrep.2014.47.2.066,https://pubmed.ncbi.nlm.nih.gov/24219866/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB16,ENSG00000189023,Neither,34573430,Whole-Genome Profiles of Malay Colorectal Cancer Patients with Intact MMR Proteins.,2021,10.3390/genes12091448,https://pubmed.ncbi.nlm.nih.gov/34573430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB16,ENSG00000189023,Neither,38926963,[Whole Exome Sequencing Reveals Gene Mutation Characteristics of Primary Central Nervous System Lymphoma].,2024,10.19746/j.cnki.issn.1009-2137.2024.03.015,https://pubmed.ncbi.nlm.nih.gov/38926963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB16,ENSG00000189023,Neither,35052827,Identification of Thrombosis-Related Genes in Patients with Advanced Gastric Cancer: Data from AGAMENON-SEOM Registry.,2022,10.3390/biomedicines10010148,https://pubmed.ncbi.nlm.nih.gov/35052827/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB16,ENSG00000189023,Neither,33676987,Granulosa cell genes that regulate ovarian follicle development beyond the antral stage: The role of estrogen receptor β.,2021,10.1016/j.mce.2021.111212,https://pubmed.ncbi.nlm.nih.gov/33676987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB16,ENSG00000189023,Neither,33714937,Retracted: Diagnostic Classification and Prognostic Prediction Using Common Genetic Variants in Autism Spectrum Disorder: Genotype-Based Deep Learning.,2021,10.2196/24754,https://pubmed.ncbi.nlm.nih.gov/33714937/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB16,ENSG00000189023,Neither,26386572,Apoptosis transcriptional mechanism of feline infectious peritonitis virus infected cells.,2015,10.1007/s10495-015-1172-7,https://pubmed.ncbi.nlm.nih.gov/26386572/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB16,ENSG00000189023,Neither,26879937,Elevated urinary urea by high-protein diet could be one of the inducements of bladder disorders.,2016,10.1186/s12967-016-0809-9,https://pubmed.ncbi.nlm.nih.gov/26879937/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB16,ENSG00000189023,Neither,22420508,"Gene expression signatures defining fundamental biological processes in pluripotent, early, and late differentiated embryonic stem cells.",2012,10.1089/scd.2011.0637,https://pubmed.ncbi.nlm.nih.gov/22420508/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB17,ENSG00000182798,Neither,35303799,MAGE genes encoding for embryonic development in cattle is mainly regulated by zinc finger transcription factor family and slightly by CpG Islands.,2022,10.1186/s12863-022-01034-0,https://pubmed.ncbi.nlm.nih.gov/35303799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB5,ENSG00000188408,Neither,35595785,X-linked palindromic gene families 4930567H17Rik and Mageb5 are dispensable for male mouse fertility.,2022,10.1038/s41598-022-12433-9,https://pubmed.ncbi.nlm.nih.gov/35595785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB5,ENSG00000188408,Neither,35937396,Expression Profile of MAGE-B1 Gene and Its Hypomethylation Activation in Colon Cancer.,2022,10.1155/2022/6066567,https://pubmed.ncbi.nlm.nih.gov/35937396/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB5,ENSG00000188408,Neither,34320928,Targeted immune epitope prediction to HHLA2 and MAGEB5 protein variants as therapeutic approach to related viral diseases.,2021,10.1186/s12865-021-00440-w,https://pubmed.ncbi.nlm.nih.gov/34320928/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB5,ENSG00000188408,Neither,29895860,Male mice with large inversions or deletions of X-chromosome palindrome arms are fertile and express their associated genes during post-meiosis.,2018,10.1038/s41598-018-27360-x,https://pubmed.ncbi.nlm.nih.gov/29895860/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB5,ENSG00000188408,Neither,10861452,"MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression.",2000,10.1002/1097-0215(20000701)87:1<55::aid-ijc8>3.0.co;2-j,https://pubmed.ncbi.nlm.nih.gov/10861452/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB6,ENSG00000176746,Neither,35937396,Expression Profile of MAGE-B1 Gene and Its Hypomethylation Activation in Colon Cancer.,2022,10.1155/2022/6066567,https://pubmed.ncbi.nlm.nih.gov/35937396/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB6,ENSG00000176746,Neither,36017582,Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia.,2022,10.1111/andr.13269,https://pubmed.ncbi.nlm.nih.gov/36017582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB6,ENSG00000176746,Neither,34307667,Trophinin Is an Important Biomarker and Prognostic Factor in Osteosarcoma: Data Mining from Oncomine and the Cancer Genome Atlas Databases.,2021,10.1155/2021/6885897,https://pubmed.ncbi.nlm.nih.gov/34307667/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB6,ENSG00000176746,Neither,30247807,A four-gene-based prognostic model predicts overall survival in patients with hepatocellular carcinoma.,2018,10.1111/jcmm.13863,https://pubmed.ncbi.nlm.nih.gov/30247807/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB6,ENSG00000176746,Neither,31516568,Prognostic roles of MAGE family members in breast cancer based on KM-Plotter Data.,2019,10.3892/ol.2019.10722,https://pubmed.ncbi.nlm.nih.gov/31516568/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB6,ENSG00000176746,Neither,25564441,A Comprehensive Expression Analysis of Cancer Testis Antigens in Head and Neck Squamous Cell Carcinoma Revels MAGEA3/6 as a Marker for Recurrence.,2015,10.1158/1535-7163.mct-14-0796,https://pubmed.ncbi.nlm.nih.gov/25564441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB6,ENSG00000176746,Neither,10861452,"MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression.",2000,10.1002/1097-0215(20000701)87:1<55::aid-ijc8>3.0.co;2-j,https://pubmed.ncbi.nlm.nih.gov/10861452/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAJIN,ENSG00000168070,Neither,42443317,Novel variants in LINC and TTM complexes of meiotic chromosome dynamics are associated with meiotic arrest and non-obstructive azoospermia.,2026,10.1038/s10038-026-01492-9,https://pubmed.ncbi.nlm.nih.gov/42443317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAJIN,ENSG00000168070,Neither,39323031,Comprehensive Analysis Identifies Hyaluronan Mediated Motility Receptor and Cell Division Cycle 25C as Potential Prognostic Biomarkers in Head and Neck Squamous Cell Carcinoma.,2024,10.1177/10732748241287904,https://pubmed.ncbi.nlm.nih.gov/39323031/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAJIN,ENSG00000168070,Neither,39545410,Defects in meiosis I contribute to the genesis of androgenetic hydatidiform moles.,2024,10.1172/jci170669,https://pubmed.ncbi.nlm.nih.gov/39545410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAJIN,ENSG00000168070,Neither,33211200,"Disruption of human meiotic telomere complex genes TERB1, TERB2 and MAJIN in men with non-obstructive azoospermia.",2021,10.1007/s00439-020-02236-1,https://pubmed.ncbi.nlm.nih.gov/33211200/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAJIN,ENSG00000168070,Neither,32408858,The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back to the common ancestor of metazoans.,2020,10.1186/s12862-020-01612-9,https://pubmed.ncbi.nlm.nih.gov/32408858/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAJIN,ENSG00000168070,Neither,35081355,The TERB1 MYB domain suppresses telomere erosion in meiotic prophase I.,2022,10.1016/j.celrep.2021.110289,https://pubmed.ncbi.nlm.nih.gov/35081355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAJIN,ENSG00000168070,Neither,33015044,Tethering of Telomeres to the Nuclear Envelope Is Mediated by SUN1-MAJIN and Possibly Promoted by SPDYA-CDK2 During Meiosis.,2020,10.3389/fcell.2020.00845,https://pubmed.ncbi.nlm.nih.gov/33015044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAJIN,ENSG00000168070,Neither,34326397,CRISPR/Cas9-based genetic screen of SCNT-reprogramming resistant genes identifies critical genes for male germ cell development in mice.,2021,10.1038/s41598-021-94851-9,https://pubmed.ncbi.nlm.nih.gov/34326397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAJIN,ENSG00000168070,Neither,30718482,The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.,2019,10.1038/s41467-019-08437-1,https://pubmed.ncbi.nlm.nih.gov/30718482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAJIN,ENSG00000168070,Neither,30559341,Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1.,2018,10.1038/s41467-018-07794-7,https://pubmed.ncbi.nlm.nih.gov/30559341/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAJIN,ENSG00000168070,Neither,36689258,Identification of potential prognostic biomarkers in vulval squamous cell carcinoma based on human papillomavirus infection Status-Analysis of GSE183454.,2023,10.1080/01443615.2022.2160930,https://pubmed.ncbi.nlm.nih.gov/36689258/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAJIN,ENSG00000168070,Neither,36753547,MJL-1 is a nuclear envelope protein required for homologous chromosome pairing and regulation of synapsis during meiosis in C. elegans.,2023,10.1126/sciadv.add1453,https://pubmed.ncbi.nlm.nih.gov/36753547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAJIN,ENSG00000168070,Neither,26548954,MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap.,2015,10.1016/j.cell.2015.10.030,https://pubmed.ncbi.nlm.nih.gov/26548954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L2,ENSG00000230522,Neither,41537300,"The expression of genes KRAS, DPM1, ACRV1, and MBD3L2 in the saliva as potential tumor markers in the detection of pancreatic cancer.",2025,10.5604/01.3001.0055.4390,https://pubmed.ncbi.nlm.nih.gov/41537300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L2,ENSG00000230522,Neither,41175375,Single-cell RNA-seq of small-intestinal neuroendocrine tumors reveals the cell of origin and gene expression of early tumor development.,2025,10.1016/j.celrep.2025.116500,https://pubmed.ncbi.nlm.nih.gov/41175375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L2,ENSG00000230522,Neither,18942147,"Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse.",2008,10.1002/dvdy.21767,https://pubmed.ncbi.nlm.nih.gov/18942147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L2,ENSG00000230522,Neither,19819433,Messenger RNA expression of Pabpnl1 and Mbd3l2 genes in oocytes and cleavage embryos.,2010,10.1016/j.fertnstert.2009.08.051,https://pubmed.ncbi.nlm.nih.gov/19819433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L2,ENSG00000230522,Neither,23966205,DUX4 and DUX4 downstream target genes are expressed in fetal FSHD muscles.,2014,10.1093/hmg/ddt409,https://pubmed.ncbi.nlm.nih.gov/23966205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L2,ENSG00000230522,Neither,23239876,"Unique features of the anti-parallel, heterodimeric coiled-coil interaction between methyl-cytosine binding domain 2 (MBD2) homologues and GATA zinc finger domain containing 2A (GATAD2A/p66α).",2013,10.1074/jbc.m112.431346,https://pubmed.ncbi.nlm.nih.gov/23239876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L2,ENSG00000230522,Neither,12504854,"MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.",2002,10.1006/geno.2002.7001,https://pubmed.ncbi.nlm.nih.gov/12504854/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L2,ENSG00000230522,Neither,15701600,MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.,2005,10.1074/jbc.m413492200,https://pubmed.ncbi.nlm.nih.gov/15701600/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L2,ENSG00000230522,Neither,22761758,Transcriptome analysis during human trophectoderm specification suggests new roles of metabolic and epigenetic genes.,2012,10.1371/journal.pone.0039306,https://pubmed.ncbi.nlm.nih.gov/22761758/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L2,ENSG00000230522,Neither,19931263,Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer.,2010,10.1053/j.gastro.2009.11.010,https://pubmed.ncbi.nlm.nih.gov/19931263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,42642181,MEIOSIN retains a STRA8-independent activity that contributes to meiotic gene activation across vertebrates.,2026,10.1101/gad.353802.126,https://pubmed.ncbi.nlm.nih.gov/42642181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,42479652,Molecular genetics of meiotic initiation in mammals.,2026,10.1093/biolre/ioag155,https://pubmed.ncbi.nlm.nih.gov/42479652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,42177587,Two compound heterozygous MEIOSIN (likely) pathogenic variants cause female infertility with premature ovarian insufficiency through the disruption of meiosis-related gene transcription.,2026,10.1186/s13048-026-02129-3,https://pubmed.ncbi.nlm.nih.gov/42177587/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,41287933,MEIOC prevents continued mitotic cycling and promotes meiotic entry during mouse oogenesis.,2026,10.1242/dev.205037,https://pubmed.ncbi.nlm.nih.gov/41287933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,41689187,TEX30 safeguards sperm morphogenesis and quality consistency required for male fertility.,2026,10.1093/reprod/xaag022,https://pubmed.ncbi.nlm.nih.gov/41689187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,42276287,Identification and characterization of a novel Plakoglobin-binding protein highly expressed in the testes.,2026,10.1016/j.bbamcr.2026.120170,https://pubmed.ncbi.nlm.nih.gov/42276287/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,39804975,Unseen Threats: The Long-term Impact of PET-Microplastics on Development of Male Reproductive Over a Lifetime.,2025,10.1002/advs.202407585,https://pubmed.ncbi.nlm.nih.gov/39804975/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,39160277,Histone demethylase KDM2A recruits HCFC1 and E2F1 to orchestrate male germ cell meiotic entry and progression.,2024,10.1038/s44318-024-00203-4,https://pubmed.ncbi.nlm.nih.gov/39160277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,38884383,Destabilization of mRNAs enhances competence to initiate meiosis in mouse spermatogenic cells.,2024,10.1242/dev.202740,https://pubmed.ncbi.nlm.nih.gov/38884383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,34472453,The role of retinoic acid in the commitment to meiosis.,2021,10.4103/aja202156,https://pubmed.ncbi.nlm.nih.gov/34472453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,41476252,REC8-Cohesin Preferentially Localizes to Promoters of Genes that are Regulated by Transcription Suppressor BEND2 During Early Meiosis.,2025,10.1093/gpbjnl/qzaf138,https://pubmed.ncbi.nlm.nih.gov/41476252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,36866926,Conserved H3K27me3-associated chromatin remodelling allows STRA8 but not MEIOSIN expression in mammalian germ cells.,2023,10.1530/rep-22-0286,https://pubmed.ncbi.nlm.nih.gov/36866926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,36927827,Cell cycle regulation for meiosis in mammalian germ cells.,2023,10.1262/jrd.2023-010,https://pubmed.ncbi.nlm.nih.gov/36927827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,38433229,MAX controls meiotic entry in sexually undifferentiated germ cells.,2024,10.1038/s41598-024-55506-7,https://pubmed.ncbi.nlm.nih.gov/38433229/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,36053973,Alternative splicing for germ cell-specific Mga transcript can be eliminated without compromising mouse viability or fertility.,2022,10.1111/dgd.12806,https://pubmed.ncbi.nlm.nih.gov/36053973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,38797021,Mechanisms of meiosis initiation and meiotic prophase progression during spermatogenesis.,2024,10.1016/j.mam.2024.101282,https://pubmed.ncbi.nlm.nih.gov/38797021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,34955498,MEIOSIN directs initiation of meiosis and subsequent meiotic prophase program during spermatogenesis.,2022,10.1266/ggs.21-00054,https://pubmed.ncbi.nlm.nih.gov/34955498/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,32097650,MEIOSIN: A New Watchman of Meiotic Initiation in Mammalian Germ Cells.,2020,10.1016/j.devcel.2020.02.002,https://pubmed.ncbi.nlm.nih.gov/32097650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,38863574,Genome-wide meta-analysis of short-tandem repeats for Parkinson's disease risk using genotype imputation.,2024,10.1093/braincomms/fcae146,https://pubmed.ncbi.nlm.nih.gov/38863574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,35372365,Recent Update on Retinoic Acid-Driven Initiation of Spermatogonial Differentiation.,2022,10.3389/fcell.2022.833759,https://pubmed.ncbi.nlm.nih.gov/35372365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,37982418,Homozygous missense variant in MEIOSIN causes premature ovarian insufficiency.,2023,10.1093/humrep/dead084,https://pubmed.ncbi.nlm.nih.gov/37982418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,26756355,Epigenetics of the myotonic dystrophy-associated DMPK gene neighborhood.,2016,10.2217/epi.15.104,https://pubmed.ncbi.nlm.nih.gov/26756355/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIOSIN,ENSG00000237452,Neither,31361310,"Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.",2019,10.1093/hmg/ddz175,https://pubmed.ncbi.nlm.nih.gov/31361310/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,41935341,MEX3B aggravates osteoarthritis progression by post-transcriptionally activating TLR4-NF-κB signaling axis.,2026,10.1186/s13018-026-06798-0,https://pubmed.ncbi.nlm.nih.gov/41935341/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,40925537,The E3 ligase MEX3B forms a tripartite complex with &lt;i&gt;Rest&lt;/i&gt; and &lt;i&gt;Hotair&lt;/i&gt; to determine the proliferative capacity of neural progenitor cells.,2025,10.1098/rsob.250164,https://pubmed.ncbi.nlm.nih.gov/40925537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,42803969,Immunophenotyping of CD8+ T Cells in Classical Hodgkin Lymphoma Reveals a Shift Toward Intermediate Exhaustion Following PD-1 Blockade.,2026,10.1158/2326-6066.cir-26-0127,https://pubmed.ncbi.nlm.nih.gov/42803969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,41613120,Integrative bioinformatic and experimental analysis reveals prognostic and immunological roles of MEX3 family genes in glioma.,2025,10.3389/fimmu.2025.1654036,https://pubmed.ncbi.nlm.nih.gov/41613120/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,40530133,Identification of the MEX3 family as potential biomarkers of hepatocellular carcinoma based on bioinformatics and experiments.,2025,10.21037/tcr-24-2095,https://pubmed.ncbi.nlm.nih.gov/40530133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,40374855,Comprehensive bioinformatics analysis of MEX3 family genes in hepatocellular carcinoma.,2025,10.1038/s41598-025-02057-0,https://pubmed.ncbi.nlm.nih.gov/40374855/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,41463882,Identification of Genes Related to Rapid Growth of Giant Grouper (&lt;i&gt;Epinephelus lanceolatus&lt;/i&gt;) Based on Self-Cross Population of Hulong Hybrid Grouper (&lt;i&gt;E. fuscoguttatus&lt;/i&gt; ♀ × &lt;i&gt;E. lanceolatus&lt;/i&gt; ♂).,2025,10.3390/ani15243599,https://pubmed.ncbi.nlm.nih.gov/41463882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,40486012,Identification of Important Diagnostic Genes in the Uterine Using Bioinformatics and Machine Learning.,2025,10.47176/mjiri.39.4,https://pubmed.ncbi.nlm.nih.gov/40486012/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,36976645,MEX3B inhibits collagen production in eosinophilic nasal polyps by downregulating epithelial cell TGFBR3 mRNA stability.,2023,10.1172/jci.insight.159058,https://pubmed.ncbi.nlm.nih.gov/36976645/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,38304027,A prognostic model based on DNA methylation-related gene expression for predicting overall survival in hepatocellular carcinoma.,2023,10.3389/fonc.2023.1171932,https://pubmed.ncbi.nlm.nih.gov/38304027/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,37192984,Mex3B inhibits DC-STAMP mRNA level and osteoclastogenesis.,2022,10.1016/j.cellin.2021.100002,https://pubmed.ncbi.nlm.nih.gov/37192984/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,36198254,rno-miR-203a-3p and Mex3B contribute to cell survival of iliopsoas muscle via the Socs3-Casp3 axis under severe hypothermia in rats.,2022,10.1016/j.legalmed.2022.102150,https://pubmed.ncbi.nlm.nih.gov/36198254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,37625735,Grass carp (Ctenopharyngodon idella) Mex3B positively regulates innate immunity by promoting the K63-linked ubiquitination of TLR3.,2023,10.1016/j.fsi.2023.109023,https://pubmed.ncbi.nlm.nih.gov/37625735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,36507941,Investigation of the Potential Correlation Between RNA-Binding Proteins in the Evolutionarily Conserved MEX3 Family and Non-small-Cell Lung Cancer.,2023,10.1007/s12033-022-00638-2,https://pubmed.ncbi.nlm.nih.gov/36507941/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,32963265,Body temperature-dependent microRNA expression analysis in rats: rno-miR-374-5p regulates apoptosis in skeletal muscle cells via Mex3B under hypothermia.,2020,10.1038/s41598-020-71931-w,https://pubmed.ncbi.nlm.nih.gov/32963265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,38326406,Molecular mechanism of specific HLA-A mRNA recognition by the RNA-binding-protein hMEX3B to promote tumor immune escape.,2024,10.1038/s42003-024-05845-y,https://pubmed.ncbi.nlm.nih.gov/38326406/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,36077598,Proteomics Profiling of Osteoporosis and Osteopenia Patients and Associated Network Analysis.,2022,10.3390/ijms231710200,https://pubmed.ncbi.nlm.nih.gov/36077598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,31330219,The IL-37-Mex3B-Toll-like receptor 3 axis in epithelial cells in patients with eosinophilic chronic rhinosinusitis with nasal polyps.,2020,10.1016/j.jaci.2019.07.009,https://pubmed.ncbi.nlm.nih.gov/31330219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,35223983,"Transcriptome Sequencing Reveals Key Genes in Three Early Phases of Osteogenic, Adipogenic, and Chondrogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Rats.",2021,10.3389/fmolb.2021.782054,https://pubmed.ncbi.nlm.nih.gov/35223983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,29496759,The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression.,2018,10.1158/1078-0432.ccr-17-2483,https://pubmed.ncbi.nlm.nih.gov/29496759/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,29674509,Antigen Presentation Keeps Trending in Immunotherapy Resistance.,2018,10.1158/1078-0432.ccr-18-0698,https://pubmed.ncbi.nlm.nih.gov/29674509/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,27338022,RNA helicase DEAD box protein 5 regulates Polycomb repressive complex 2/Hox transcript antisense intergenic RNA function in hepatitis B virus infection and hepatocarcinogenesis.,2016,10.1002/hep.28698,https://pubmed.ncbi.nlm.nih.gov/27338022/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,29515040,A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes.,2018,10.1172/jci.insight.98212,https://pubmed.ncbi.nlm.nih.gov/29515040/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3B,ENSG00000183496,Neither,17267406,"Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies.",2007,10.1093/nar/gkm016,https://pubmed.ncbi.nlm.nih.gov/17267406/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,42774548,Integrative multi-omics and bioinformatic analysis of &lt;i&gt;MMP20&lt;/i&gt; in amelogenesis imperfecta.,2026,10.1016/j.jdsr.2026.08.003,https://pubmed.ncbi.nlm.nih.gov/42774548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,41585151,Novel &lt;i&gt;MMP20&lt;/i&gt; (matrix metalloproteinase 20) mutations causing hypoplastic-hypomaturation amelogenesis imperfecta.,2026,10.1016/j.jds.2025.08.039,https://pubmed.ncbi.nlm.nih.gov/41585151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,41765949,Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration.,2026,10.1038/s41368-026-00429-4,https://pubmed.ncbi.nlm.nih.gov/41765949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,42505729,Human Enamel Formation: A Scoping Review for Oral Health Professionals.,2026,10.3390/dj14070421,https://pubmed.ncbi.nlm.nih.gov/42505729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,39859478,"Expression of AMELX, AMBN, ENAM, TUFT1, FAM83H and MMP20 Genes in Buccal Epithelial Cells from Patients with Molar Incisor Hypomineralization (MIH)-A Pilot Study.",2025,10.3390/ijms26020766,https://pubmed.ncbi.nlm.nih.gov/39859478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,41529728,Amelogenin proteolysis orchestrates functional amyloid pathways in enamel development.,2026,10.1016/j.matbio.2026.01.001,https://pubmed.ncbi.nlm.nih.gov/41529728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,37914726,"Mobility gene expression differences among wild-type, Mmp20 null and Mmp20 over-expresser mice plus visualization of 3D mouse ameloblast directional movement.",2023,10.1038/s41598-023-44627-0,https://pubmed.ncbi.nlm.nih.gov/37914726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,41774401,Differential Effects of DLX3 Mutations Drive Phenotypic Variability in Tricho-Dento-Osseous Syndrome via Direct Activation of WNT10A.,2026,10.1111/nyas.70228,https://pubmed.ncbi.nlm.nih.gov/41774401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,41673565,Sfrp4 Is Required for Proper Dental Formation and Stem Cell Regulation.,2026,10.1177/00220345261416408,https://pubmed.ncbi.nlm.nih.gov/41673565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,41851763,Epigenetic biomarkers of progestin-resistance in endometriosis.,2026,10.1186/s40364-026-00907-1,https://pubmed.ncbi.nlm.nih.gov/41851763/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,41305856,Stage-Specific Proteomic Profiles in Dental Caries.,2026,10.1177/00220345251392212,https://pubmed.ncbi.nlm.nih.gov/41305856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,40773061,Reduction of Tooth Replacement Disproportionately Affects the Evolution of Enamel Matrix Proteins.,2025,10.1007/s00239-025-10258-4,https://pubmed.ncbi.nlm.nih.gov/40773061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,42036473,"Serine-16 Phosphorylation, C-Terminal Truncation, and Ion-Specific Interactions Coordinate Amelogenin Nanoribbon Formation.",2026,10.1007/s00223-026-01505-x,https://pubmed.ncbi.nlm.nih.gov/42036473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,40444759,Epithelial YAP1 Regulates Ameloblast Differentiation through SHH/FGF Signaling.,2025,10.1177/00220345251336164,https://pubmed.ncbi.nlm.nih.gov/40444759/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,40725478,Integrating Imaging and Genomics in Amelogenesis Imperfecta: A Novel Diagnostic Approach.,2025,10.3390/genes16070822,https://pubmed.ncbi.nlm.nih.gov/40725478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,38269199,CRISPR/Cas9-Induced Fam83h Knock-out Leads to Impaired Wnt/β-Catenin Pathway and Altered Expression of Tooth Mineralization Genes in Mice.,2023,10.30498/ijb.2023.391902.3673,https://pubmed.ncbi.nlm.nih.gov/38269199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,39273410,Salivary Molecular Spectroscopy with Machine Learning Algorithms for a Diagnostic Triage for Amelogenesis Imperfecta.,2024,10.3390/ijms25179464,https://pubmed.ncbi.nlm.nih.gov/39273410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,40073999,Osteogenesis Potential of Polymethylmethacrylate-Hydroxyapatite and Stem Cells from Human Exfoliated Deciduous Teeth as Alveolar Bone Graft: An In Silico Study.,2025,10.1055/s-0044-1801280,https://pubmed.ncbi.nlm.nih.gov/40073999/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,38740354,Investigation of diabetes-related molecular changes in embryo-endometrium crosstalk.,2024,10.1016/j.gene.2024.148557,https://pubmed.ncbi.nlm.nih.gov/38740354/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,36326426,Phenotypic variability in LAMA3-associated amelogenesis imperfecta.,2023,10.1111/odi.14425,https://pubmed.ncbi.nlm.nih.gov/36326426/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,33914777,"Lung development, repair and cancer: A study on the role of MMP20 gene in adenocarcinoma.",2021,10.1371/journal.pone.0250552,https://pubmed.ncbi.nlm.nih.gov/33914777/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,40078563,Improving neuroblastoma risk prediction through a polygenic risk score derived from genome-wide association study-identified loci.,2025,10.21147/j.issn.1000-9604.2025.01.01,https://pubmed.ncbi.nlm.nih.gov/40078563/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,32495503,Dental malformations associated with biallelic MMP20 mutations.,2020,10.1002/mgg3.1307,https://pubmed.ncbi.nlm.nih.gov/32495503/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,37569643,Gene-Smoking Interaction Analysis for the Identification of Novel Asthma-Associated Genetic Factors.,2023,10.3390/ijms241512266,https://pubmed.ncbi.nlm.nih.gov/37569643/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,36456645,Development and validation of a novel immune-related prognostic signature in lung squamous cell carcinoma patients.,2022,10.1038/s41598-022-23140-w,https://pubmed.ncbi.nlm.nih.gov/36456645/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,31575895,"ADAM10 is Expressed by Ameloblasts, Cleaves the RELT TNF Receptor Extracellular Domain and Facilitates Enamel Development.",2019,10.1038/s41598-019-50277-y,https://pubmed.ncbi.nlm.nih.gov/31575895/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,36941602,Identification of the MMP family as therapeutic targets and prognostic biomarkers in the microenvironment of head and neck squamous cell carcinoma.,2023,10.1186/s12967-023-04052-3,https://pubmed.ncbi.nlm.nih.gov/36941602/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,29481294,MMP20 Overexpression Disrupts Molar Ameloblast Polarity and Migration.,2018,10.1177/0022034518758657,https://pubmed.ncbi.nlm.nih.gov/29481294/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,35069702,Landscape Analysis of Matrix Metalloproteinases Unveils Key Prognostic Markers for Patients With Breast Cancer.,2021,10.3389/fgene.2021.809600,https://pubmed.ncbi.nlm.nih.gov/35069702/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,37228816,Amelogenesis imperfecta: Next-generation sequencing sheds light on Witkop's classification.,2023,10.3389/fphys.2023.1130175,https://pubmed.ncbi.nlm.nih.gov/37228816/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP20,ENSG00000137674,Neither,20531944,The acid test of fluoride: how pH modulates toxicity.,2010,10.1371/journal.pone.0010895,https://pubmed.ncbi.nlm.nih.gov/20531944/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42505343,Asthma: Is It Time for Monocytes to Share the Spotlight?,2026,10.3390/cells15141233,https://pubmed.ncbi.nlm.nih.gov/42505343/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42638140,Mannooligosaccharides modulate mucin O-glycan-gut microbe interactions and preserve the intestinal barrier in weaned piglets.,2026,10.1186/s40104-026-01492-x,https://pubmed.ncbi.nlm.nih.gov/42638140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,41561043,&lt;i&gt;Morinda officinalis&lt;/i&gt; oligosaccharides improves sperm motility via the gut microbiota and the IGF-1/PI3K/mTOR signaling pathway.,2025,10.3389/fendo.2025.1711475,https://pubmed.ncbi.nlm.nih.gov/41561043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,41637829,Comprehensive transcriptome analysis of somatic and gonadal tissues for identification of sex-biased genes in spotted scat (Scatophagus argus).,2026,10.1016/j.cbd.2026.101767,https://pubmed.ncbi.nlm.nih.gov/41637829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42757456,Monocytes in pneumonia: Functional plasticity and innate memory (Review).,2026,10.3892/ijmm.2026.5986,https://pubmed.ncbi.nlm.nih.gov/42757456/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42741448,"Case Report: Mixed gonadal dysgenesis with Müllerian remnants mimicking a prostatic utricle in a child with 45,X/46,XY/47,XYY mosaicism.",2026,10.3389/fped.2026.1915927,https://pubmed.ncbi.nlm.nih.gov/42741448/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42404158,Comparative effects of β-glucan and mannan oligosaccharides on heat stress-induced inflammation: associations with gut barrier integrity and intestinal microbiota in mice.,2026,10.3389/fnut.2026.1852838,https://pubmed.ncbi.nlm.nih.gov/42404158/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,41786823,Yeast prebiotics mitigate lead toxicity in Nile tilapia through physiological and ultrastructural improvements.,2026,10.1038/s41598-026-37841-z,https://pubmed.ncbi.nlm.nih.gov/41786823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42914604,A microwave-conditioned MoS₂-tomato extracellular vesicle hydrogel drives photothermal-photoelectric reprogramming of chronic wounds.,2026,10.1016/j.bioadv.2026.215235,https://pubmed.ncbi.nlm.nih.gov/42914604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42814153,Amplification-free colorimetric detection of exosomal miRNA using a CRISPR/Cas13a-activated HRP/Au/MoS&lt;sub&gt;2&lt;/sub&gt; nanobiohybrid catalyst.,2026,10.1186/s40580-026-00580-y,https://pubmed.ncbi.nlm.nih.gov/42814153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42376010,Cu&lt;sub&gt;2&lt;/sub&gt;MoS&lt;sub&gt;4&lt;/sub&gt; nanozymes reduced bacterial defenses through a dual mechanism to amplify cuproptosis-like death and accelerate the healing of burn-infected wounds.,2026,10.1016/j.bioactmat.2026.05.056,https://pubmed.ncbi.nlm.nih.gov/42376010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42533383,Sulfur Vacancy-Rich MoS&lt;sub&gt;2&lt;/sub&gt; Nanodot-Based Hybrid Eye Drops as an Antibiotic-Free Antifungus for Fungal Keratitis Therapy.,2026,10.1002/adhm.71459,https://pubmed.ncbi.nlm.nih.gov/42533383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,41145439,An eNOS-like nanomaterial for specific reversal of cerebral ischemia-reperfusion injury.,2025,10.1038/s41467-025-64518-4,https://pubmed.ncbi.nlm.nih.gov/41145439/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42774191,Effects of slope on lower-limb bilateral asymmetry and dynamic stability during running.,2026,10.3389/fphys.2026.1947077,https://pubmed.ncbi.nlm.nih.gov/42774191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42548153,Intra-MRI Head Motion Tracking and Correction: A Quantitative In Vivo Evaluation Framework.,2026,10.1002/nbm.70368,https://pubmed.ncbi.nlm.nih.gov/42548153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42743620,Early motor behavior reflects neurologic involvement in infants with congenital heart disease.,2026,10.1016/j.earlhumdev.2026.106663,https://pubmed.ncbi.nlm.nih.gov/42743620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,40855335,"Acute, sub-acute and developmental toxicity studies of molybdenum disulfide nanoflowers in rats, as per OECD guidelines.",2025,10.1186/s40360-025-00881-8,https://pubmed.ncbi.nlm.nih.gov/40855335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42880551,Ubiquitin-Like protein UBL1 orchestrates monocyte recruitment and pro-inflammatory macrophage activation in critical limb ischemia: Involving SUMOylation and stabilization of PER1.,2026,10.1016/j.bcp.2026.118546,https://pubmed.ncbi.nlm.nih.gov/42880551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42691557,Robustness of mediolateral stability measures to different operationalizations of the center of mass and base of support.,2026,10.1016/j.jbiomech.2026.113520,https://pubmed.ncbi.nlm.nih.gov/42691557/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,41856686,Morvan syndrome in a patient with progressing metastatic thymoma and myasthenia gravis.,2026,10.1136/bcr-2025-271140,https://pubmed.ncbi.nlm.nih.gov/41856686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42752531,PDS0101 With Pembrolizumab in HPV16-Positive Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma: A Phase 2 Nonrandomized Clinical Trial.,2026,10.1001/jamaoncol.2026.3492,https://pubmed.ncbi.nlm.nih.gov/42752531/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42769789,Immunotherapy in Bellini Duct Carcinoma: A Systematic Review.,2026,10.32604/or.2026.081674,https://pubmed.ncbi.nlm.nih.gov/42769789/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42694766,Safety and efficacy of PRaG therapy in elderly cancer patients.,2026,10.1093/immadv/ltag019,https://pubmed.ncbi.nlm.nih.gov/42694766/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42855460,"The conformation-selective PI3Kδ inhibitor roginolisib in patients with advanced or metastatic cancer, including metastatic uveal melanoma: first-in-human clinical trial.",2026,10.1038/s41467-026-77358-7,https://pubmed.ncbi.nlm.nih.gov/42855460/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42760803,Rechallenge With Immunotherapy for ES-SCLC: Efficacy and Safety From a Retrospective Propensity Score-Matched Study.,2026,10.1002/cam4.72304,https://pubmed.ncbi.nlm.nih.gov/42760803/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42012665,"Envafolimab combined with lenvatinib and albumin-bound paclitaxel in previously treated advanced gastric/gastroesophageal junction (G/GEJ) adenocarcinoma: a prospective, phase II, multi-cohort trial.",2026,10.1007/s00262-026-04373-4,https://pubmed.ncbi.nlm.nih.gov/42012665/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42496766,Clinical efficacy and safety outcomes of anlotinib therapy in sarcoma: a systematic review and meta-analysis.,2026,10.1186/s43046-026-00384-5,https://pubmed.ncbi.nlm.nih.gov/42496766/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,40921630,Randomized clinical efficacy and safety study of peltopepimut-S plus cemiplimab compared to cemiplimab alone in patients with recurrent/metastatic HPV16-positive head and neck cancer.,2025,10.1136/jitc-2025-012555,https://pubmed.ncbi.nlm.nih.gov/40921630/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42640561,Real-world efficacy and toxicity of tebentafusp in metastatic uveal melanoma patients treated on the United Kingdom expanded access programme.,2026,10.1093/oncolo/oyag341,https://pubmed.ncbi.nlm.nih.gov/42640561/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42558713,Efficacy and safety of immunotherapy combined with chemoradiotherapy in limited-stage small cell lung cancer: a systematic evaluation and meta-analysis of randomized controlled trials.,2026,10.3389/fimmu.2026.1731036,https://pubmed.ncbi.nlm.nih.gov/42558713/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42180940,Metronomic chemotherapy combined with immunotherapy in solid tumor: a systematic review.,2026,10.21037/tcr-2025-1-2912,https://pubmed.ncbi.nlm.nih.gov/42180940/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42406230,"Immune checkpoint inhibitors in advanced cholangiocarcinoma: a systematic review of efficacy, safety, and emerging biomarkers.",2026,10.1186/s43046-026-00381-8,https://pubmed.ncbi.nlm.nih.gov/42406230/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,41591505,A phase 2 study of orally administered live biotherapeutic salmonella-IL2 with FOLFIRINOX for stage IV pancreatic cancer.,2026,10.1007/s00262-026-04307-0,https://pubmed.ncbi.nlm.nih.gov/41591505/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42686374,Overall survival of immunotherapy versus standard of care in chemorefractory microsatellite stable metastatic colorectal cancer: a propensity score matched analysis of 708 patients.,2026,10.1136/jitc-2026-015414,https://pubmed.ncbi.nlm.nih.gov/42686374/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42688407,The efficacy and safety of pembrolizumab in the treatment of HER2-negative advanced gastric or gastroesophageal junction cancer: a systematic review and meta-analysis of emerging clinical data.,2026,10.3389/fimmu.2026.1862751,https://pubmed.ncbi.nlm.nih.gov/42688407/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42828095,Real-world survival benefit of adding durvalumab to chemotherapy in cholangiocarcinoma: a retrospective cohort analysis from a German Comprehensive Cancer Centre.,2026,10.1016/j.esmorw.2026.100783,https://pubmed.ncbi.nlm.nih.gov/42828095/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,41375018,Emerging and Investigational Systemic Therapies in Recurrent/Metastatic Head and Neck Cancer After Progression on Immunotherapy.,2025,10.3390/cancers17233817,https://pubmed.ncbi.nlm.nih.gov/41375018/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,40725830,Advances and Challenges in Immunotherapy for Metastatic Uveal Melanoma: Clinical Strategies and Emerging Targets.,2025,10.3390/jcm14145137,https://pubmed.ncbi.nlm.nih.gov/40725830/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42578008,Clinical Efficacy and Safety of Pembrolizumab-Based Therapy in Recurrent or Advanced Cervical Cancer: A Systematic Review and Meta-Analysis.,2026,10.2147/ott.s612659,https://pubmed.ncbi.nlm.nih.gov/42578008/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,42564214,Real-world treatment patterns and outcomes of chemo-immunotherapy with or without radiotherapy in extensive-stage small cell lung cancer: the durvalumab expanded access cohort.,2026,10.3389/fonc.2026.1821628,https://pubmed.ncbi.nlm.nih.gov/42564214/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOS,ENSG00000172680,Neither,34779126,Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation.,2021,10.15252/emmm.202114887,https://pubmed.ncbi.nlm.nih.gov/34779126/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPC1L,ENSG00000238205,Neither,40249800,Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier.,2025,10.1126/sciadv.adw1489,https://pubmed.ncbi.nlm.nih.gov/40249800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPC1L,ENSG00000238205,Neither,37366179,"Fifty years of the mitochondrial pyruvate carrier: New insights into its structure, function, and inhibition.",2023,10.1111/apha.14016,https://pubmed.ncbi.nlm.nih.gov/37366179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPC1L,ENSG00000238205,Neither,27317664,MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells.,2016,10.1074/jbc.m116.733840,https://pubmed.ncbi.nlm.nih.gov/27317664/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRG,ENSG00000182170,Neither,42269381,International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors.,2026,10.1016/j.pharmr.2026.100141,https://pubmed.ncbi.nlm.nih.gov/42269381/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRG,ENSG00000182170,Neither,32999394,Identification of the dog orthologue of human MAS-related G protein coupled receptor X2 (MRGPRX2) essential for drug-induced pseudo-allergic reactions.,2020,10.1038/s41598-020-72819-5,https://pubmed.ncbi.nlm.nih.gov/32999394/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRG,ENSG00000182170,Neither,34306024,Identification and Validation of Immune-Related LncRNA Prognostic Signature for Lung Adenocarcinoma.,2021,10.3389/fgene.2021.681277,https://pubmed.ncbi.nlm.nih.gov/34306024/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRG,ENSG00000182170,Neither,37195203,Systematic d-Amino Acid Substitutions to Control Peptide and Hydrogel Degradation in Cellular Microenvironments.,2023,10.1021/acsmacrolett.3c00144,https://pubmed.ncbi.nlm.nih.gov/37195203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRG,ENSG00000182170,Neither,34295964,Collagenase-Cleavable Peptide Amphiphile Micelles as a Novel Theranostic Strategy in Atherosclerosis.,2020,10.1002/adtp.201900196,https://pubmed.ncbi.nlm.nih.gov/34295964/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRG,ENSG00000182170,Neither,24943402,Protease-sensitive PEG hydrogels regulate vascularization in vitro and in vivo.,2014,10.1002/mabi.201400161,https://pubmed.ncbi.nlm.nih.gov/24943402/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRG,ENSG00000182170,Neither,25944819,Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome.,2015,10.1093/ije/dyv043,https://pubmed.ncbi.nlm.nih.gov/25944819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,42825856,Bile acid signaling in health and disease.,2026,10.1186/s43556-026-00603-4,https://pubmed.ncbi.nlm.nih.gov/42825856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,41957282,Development of a clinically viable MRGPRX4 inverse agonist for cholestatic itch treatment.,2026,10.1038/s41589-026-02195-0,https://pubmed.ncbi.nlm.nih.gov/41957282/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,40959244,Terpene-Based Thiazole Hydrazines as Negative Allosteric Modulators of MRGPRX4: In Vitro Evaluation and Binding Site Analysis.,2025,10.1021/acsmedchemlett.5c00354,https://pubmed.ncbi.nlm.nih.gov/40959244/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,42095223,Advances in research on the effects of bile acids and their receptors on intestinal function.,2026,10.3389/fnut.2026.1821418,https://pubmed.ncbi.nlm.nih.gov/42095223/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,40628364,The role of bile salts in itch receptor activation.,2025,10.1016/j.bbadis.2025.167972,https://pubmed.ncbi.nlm.nih.gov/40628364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,38718132,MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model.,2024,10.1126/scitranslmed.adk8198,https://pubmed.ncbi.nlm.nih.gov/38718132/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,41637656,Structure-Based Discovery of Obeticholic Acid Derivatives as Novel Farnesoid X Receptor Partial Agonists with Improved Selectivity and Reduced Off-Target Effects.,2026,10.1002/cmdc.202500960,https://pubmed.ncbi.nlm.nih.gov/41637656/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,37003505,Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins.,2023,10.1016/j.jbc.2023.104664,https://pubmed.ncbi.nlm.nih.gov/37003505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,41064326,"Modular and diverse synthesis of oxaheterocycles &lt;i&gt;via&lt;/i&gt; Pd-catalyzed migratory 1,&lt;i&gt;n&lt;/i&gt;-cycloannulation of alkenes.",2025,10.1039/d5sc06539a,https://pubmed.ncbi.nlm.nih.gov/41064326/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,39476841,Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch.,2024,10.1016/j.cell.2024.10.001,https://pubmed.ncbi.nlm.nih.gov/39476841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,31500698,MRGPRX4 is a bile acid receptor for human cholestatic itch.,2019,10.7554/elife.48431,https://pubmed.ncbi.nlm.nih.gov/31500698/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,34161994,MRGPRX4 in Cholestatic Pruritus.,2021,10.1055/s-0041-1730923,https://pubmed.ncbi.nlm.nih.gov/34161994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,38428307,Improvement of NASH and liver fibrosis through modulation of the gut-liver axis by a novel intestinal FXR agonist.,2024,10.1016/j.biopha.2024.116331,https://pubmed.ncbi.nlm.nih.gov/38428307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,34789874,"Structure, function and pharmacology of human itch GPCRs.",2021,10.1038/s41586-021-04126-6,https://pubmed.ncbi.nlm.nih.gov/34789874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,34263729,"Lithocholic Acid Activates Mas-Related G Protein-Coupled Receptors, Contributing to Itch in Mice.",2022,10.4062/biomolther.2021.059,https://pubmed.ncbi.nlm.nih.gov/34263729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,31068464,MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus.,2019,10.1073/pnas.1903316116,https://pubmed.ncbi.nlm.nih.gov/31068464/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,36739914,How to get rid of itching.,2023,10.1016/j.pharmthera.2023.108355,https://pubmed.ncbi.nlm.nih.gov/36739914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,30768591,An African-specific haplotype in MRGPRX4 is associated with menthol cigarette smoking.,2019,10.1371/journal.pgen.1007916,https://pubmed.ncbi.nlm.nih.gov/30768591/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,35934214,MAS-related G protein-coupled receptors X (MRGPRX): Orphan GPCRs with potential as targets for future drugs.,2022,10.1016/j.pharmthera.2022.108259,https://pubmed.ncbi.nlm.nih.gov/35934214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,36809835,New Treatment Paradigms in Primary Biliary Cholangitis.,2023,10.1016/j.cgh.2023.02.005,https://pubmed.ncbi.nlm.nih.gov/36809835/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,42800553,"EP547 (MRGPRX4 inverse agonist) for cholestatic pruritus due to primary biliary cholangitis or primary sclerosing cholangitis: Results from the phase 2 randomized, placebo-controlled PACIFIC study.",2026,10.1016/j.aohep.2026.102449,https://pubmed.ncbi.nlm.nih.gov/42800553/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,42102281,Discovery of Non-Carboxylic Steroidal FXR Agonist as a Promising Preclinical Candidate for Metabolic Dysfunction-Associated Steatohepatitis.,2026,10.1021/acs.jmedchem.5c03220,https://pubmed.ncbi.nlm.nih.gov/42102281/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,42232646,New and emerging treatments for PBC-related pruritus.,2026,10.7573/dic.2025-12-3,https://pubmed.ncbi.nlm.nih.gov/42232646/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,30657454,Identification of a bilirubin receptor that may mediate a component of cholestatic itch.,2019,10.7554/elife.44116,https://pubmed.ncbi.nlm.nih.gov/30657454/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRGPRX4,ENSG00000179817,Neither,11850634,Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs.,2002,10.1038/nn815,https://pubmed.ncbi.nlm.nih.gov/11850634/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A13,ENSG00000204979,Neither,28971897,Subcellular localization of MS4A13 isoform 2 in mouse spermatozoa.,2017,10.1530/rep-17-0477,https://pubmed.ncbi.nlm.nih.gov/28971897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A5,ENSG00000166930,Neither,11162526,"Isolation, tissue distribution, and chromosomal localization of a novel testis-specific human four-transmembrane gene related to CD20 and FcepsilonRI-beta.",2001,10.1006/bbrc.2000.4088,https://pubmed.ncbi.nlm.nih.gov/11162526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSL3B,ENSG00000293137,Neither,38718076,Long Noncoding RNA MSL3P1 Regulates CUL3 mRNA Cytoplasmic Transport and Stability and Promotes Lung Adenocarcinoma Metastasis.,2024,10.1158/1541-7786.mcr-23-0977,https://pubmed.ncbi.nlm.nih.gov/38718076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSL3B,ENSG00000293137,Neither,37917782,Uncovering key molecular mechanisms in the early and late-stage of papillary thyroid carcinoma using association rule mining algorithm.,2023,10.1371/journal.pone.0293335,https://pubmed.ncbi.nlm.nih.gov/37917782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSL3B,ENSG00000293137,Neither,30337839,New insights into long noncoding RNAs and pseudogenes in prognosis of renal cell carcinoma.,2018,10.1186/s12935-018-0652-6,https://pubmed.ncbi.nlm.nih.gov/30337839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSL3B,ENSG00000293137,Neither,33353109,Molecular Network Profiling in Intestinal- and Diffuse-Type Gastric Cancer.,2020,10.3390/cancers12123833,https://pubmed.ncbi.nlm.nih.gov/33353109/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO1H,ENSG00000174527,Neither,42688997,Association between myosin 1H polymorphisms and skeletal-facial profile in Taiwanese patients with mandibular prognathism.,2026,10.1016/j.jds.2025.11.015,https://pubmed.ncbi.nlm.nih.gov/42688997/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO1H,ENSG00000174527,Neither,41188450,PHOX2B deletion in congenital central hypoventilation syndrome: is this sufficient for pathogenesis?,2026,10.1038/s10038-025-01429-8,https://pubmed.ncbi.nlm.nih.gov/41188450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO1H,ENSG00000174527,Neither,41880348,Genetic variants associated with systemic inflammatory disease associate with temporomandibular symptoms with or without periodontitis.,2026,10.1371/journal.pone.0328855,https://pubmed.ncbi.nlm.nih.gov/41880348/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO1H,ENSG00000174527,Neither,36039325,The association of polymorphisms in BMP2/MYO1H and skeletal Class II div.1 maxillary and mandibular dimensions. A preliminary 'report.,2022,10.1016/j.sjbs.2022.103405,https://pubmed.ncbi.nlm.nih.gov/36039325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO1H,ENSG00000174527,Neither,39787278,Association between the methyl-CpG-binding domain protein 5 gene and depressive symptoms in a Mexican population: results from the MxGDAR/Encodat cohort.,2025,10.47626/1516-4446-2024-3859,https://pubmed.ncbi.nlm.nih.gov/39787278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO1H,ENSG00000174527,Neither,34877573,Analysis of MYO1H Gene Polymorphism in Skeletal Class-III Malocclusion Due to Mandibular Prognathism.,2021,10.1055/s-0041-1731066,https://pubmed.ncbi.nlm.nih.gov/34877573/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO1H,ENSG00000174527,Neither,35608565,Influence of genotype and perioral musculature on maxillary and mandibular development.,2022,10.2319/112821-868.1,https://pubmed.ncbi.nlm.nih.gov/35608565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO1H,ENSG00000174527,Neither,35362676,BMPR-IB gene disruption causes severe limb deformities in pigs.,2022,10.24272/j.issn.2095-8137.2021.291,https://pubmed.ncbi.nlm.nih.gov/35362676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO1H,ENSG00000174527,Neither,30366217,Genetic variants in ACTN3 and MYO1H are associated with sagittal and vertical craniofacial skeletal patterns.,2019,10.1016/j.archoralbio.2018.09.018,https://pubmed.ncbi.nlm.nih.gov/30366217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO1H,ENSG00000174527,Neither,29986156,Identification and Functional Studies of MYO1H for Mandibular Prognathism.,2018,10.1177/0022034518784936,https://pubmed.ncbi.nlm.nih.gov/29986156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO1H,ENSG00000174527,Neither,27131252,Role of myosin 1H gene polymorphisms in mandibular retrognathism.,2016,10.1016/j.ajodo.2015.10.028,https://pubmed.ncbi.nlm.nih.gov/27131252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO1H,ENSG00000174527,Neither,28364893,Genetic polymorphisms underlying the skeletal Class III phenotype.,2017,10.1016/j.ajodo.2016.09.013,https://pubmed.ncbi.nlm.nih.gov/28364893/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO1H,ENSG00000174527,Neither,24698832,"Molecular motor MYO1C, acetyltransferase KAT6B and osteogenetic transcription factor RUNX2 expression in human masseter muscle contributes to development of malocclusion.",2014,10.1016/j.archoralbio.2014.03.005,https://pubmed.ncbi.nlm.nih.gov/24698832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO1H,ENSG00000174527,Neither,25910506,Candidate Gene Analyses of Skeletal Variation in Malocclusion.,2015,10.1177/0022034515581643,https://pubmed.ncbi.nlm.nih.gov/25910506/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO1H,ENSG00000174527,Neither,28570402,Genetic Factors Involved in Mandibular Prognathism.,2017,10.1097/scs.0000000000003627,https://pubmed.ncbi.nlm.nih.gov/28570402/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO1H,ENSG00000174527,Neither,22196185,Genetic variation in myosin 1H contributes to mandibular prognathism.,2012,10.1016/j.ajodo.2011.06.033,https://pubmed.ncbi.nlm.nih.gov/22196185/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO1H,ENSG00000174527,Neither,12486594,Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia.,2002,10.1007/s101620020049,https://pubmed.ncbi.nlm.nih.gov/12486594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NBPF4,ENSG00000196427,Neither,42639147,MRI-Based Deep Learning Guides Multi-Omics Discovery of NBPF4 as a Therapeutic Target for Breast Cancer Lymph Node Metastasis.,2026,10.34133/research.1402,https://pubmed.ncbi.nlm.nih.gov/42639147/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NBPF4,ENSG00000196427,Neither,34405537,NBPF4 mitigates progression in colorectal cancer through the regulation of EZH2-associated ETFA.,2021,10.1111/jcmm.16867,https://pubmed.ncbi.nlm.nih.gov/34405537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NBPF4,ENSG00000196427,Neither,26019623,Whole genome microarray analysis in non-small cell lung cancer.,2015,10.1080/13102818.2014.989179,https://pubmed.ncbi.nlm.nih.gov/26019623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NBPF4,ENSG00000196427,Neither,23741398,Genomic copy number variants: evidence for association with antibody response to anthrax vaccine adsorbed.,2013,10.1371/journal.pone.0064813,https://pubmed.ncbi.nlm.nih.gov/23741398/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NBPF4,ENSG00000196427,Neither,16079250,A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.,2005,10.1093/molbev/msi222,https://pubmed.ncbi.nlm.nih.gov/16079250/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,41081101,Evaluation of NEUROG1 methylation status in stool specimens in the advanced adenomas and colorectal cancer.,2025,10.7717/peerj.19968,https://pubmed.ncbi.nlm.nih.gov/41081101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,42380286,Therapeutic effect of intranasal nicotinamide adenine dinucleotide in the restoration of olfactory dysfunction.,2026,10.1038/s12276-026-01761-9,https://pubmed.ncbi.nlm.nih.gov/42380286/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,41260345,Zebrafish pou3f3b controls saccular/auditory development and marks non-neuronal cells that delaminate from the otic vesicle to promote neuroblast maturation.,2026,10.1016/j.ydbio.2025.11.010,https://pubmed.ncbi.nlm.nih.gov/41260345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,41533511,Expression dynamics of functionally equivalent Neurog1/2 genes enable protracted neurogenesis and temporal emergence of somatosensory neuron lineages.,2026,10.1016/j.celrep.2025.116798,https://pubmed.ncbi.nlm.nih.gov/41533511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,42004514,Prenatal morphine exposure induces molecular and structural alterations in the developing hippocampus of neonatal rats.,2026,10.22038/ijbms.2025.90146.19436,https://pubmed.ncbi.nlm.nih.gov/42004514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,42228282,Olfactory epithelium regeneration and homeostasis: cellular and molecular mechanisms and novel methodological advances.,2026,10.1186/s13619-026-00292-y,https://pubmed.ncbi.nlm.nih.gov/42228282/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,42425092,Induction of human pruriceptors from pluripotent stem cells via transcription factors.,2026,10.1016/j.stemcr.2026.103004,https://pubmed.ncbi.nlm.nih.gov/42425092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,41718161,Vestigial-like 4 Regulates Neurogenesis and Neural Crest Formation During &lt;i&gt;Xenopus&lt;/i&gt; Development.,2026,10.3390/jdb14010008,https://pubmed.ncbi.nlm.nih.gov/41718161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,41455076,Characteristics and Cell Lineage Tracing of Neurod1-Cre and Neurod1-iCreER Mice Targeting Cochlear Neurons.,2026,10.1007/s12264-025-01567-1,https://pubmed.ncbi.nlm.nih.gov/41455076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,40545564,Neocortical neurogenesis: a proneural gene perspective.,2025,10.1111/febs.70158,https://pubmed.ncbi.nlm.nih.gov/40545564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,41491447,"Regulatory Networks Driving the Specification, Differentiation, and Diversification of Neurons in the Mouse Inner Ear.",2026,10.1007/s10162-025-01024-w,https://pubmed.ncbi.nlm.nih.gov/41491447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,39680368,Examining the NEUROG2 lineage and associated gene expression in human cortical organoids.,2025,10.1242/dev.202703,https://pubmed.ncbi.nlm.nih.gov/39680368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,40789910,Extremely low-frequency electromagnetic fields facilitate proliferation and functional differentiation in spinal neural stem cells.,2025,10.1038/s41598-025-14738-x,https://pubmed.ncbi.nlm.nih.gov/40789910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,42899711,Large-scale proteomics identifies a pretreatment Crohn's disease core proteome and a dynamic signature for anti-TNF response.,2026,10.1093/ibd/izag221,https://pubmed.ncbi.nlm.nih.gov/42899711/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,42680049,Exploring potential targets and mechanisms of 4-methylbenzylidene camphor-induced developmental neurotoxicity: Integration of network toxicology and zebrafish experimental validation.,2026,10.1016/j.envpol.2026.129076,https://pubmed.ncbi.nlm.nih.gov/42680049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,41744763,Direct Conversion of Mouse Fibroblasts into Photoreceptor-like Cells.,2026,10.3390/cells15040320,https://pubmed.ncbi.nlm.nih.gov/41744763/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,40727251,"Camrelizumab, an Anti-PD-1 Monoclonal Antibody, Plus Carboplatin and Nab-Paclitaxel as First-Line Setting for Extensive-Stage Small-Cell Lung Cancer: A Phase 2 Trial and Biomarker Analysis.",2025,10.1002/mco2.70300,https://pubmed.ncbi.nlm.nih.gov/40727251/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,38731859,Dolutegravir and Folic Acid Interaction during Neural System Development in Zebrafish Embryos.,2024,10.3390/ijms25094640,https://pubmed.ncbi.nlm.nih.gov/38731859/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,38456494,Foxp and Skor family proteins control differentiation of Purkinje cells from Ptf1a- and Neurog1-expressing progenitors in zebrafish.,2024,10.1242/dev.202546,https://pubmed.ncbi.nlm.nih.gov/38456494/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,36647078,A novel case of two siblings harbouring homozygous variant in the NEUROG1 gene with autism as an additional phenotype: a case report.,2023,10.1186/s12883-023-03065-1,https://pubmed.ncbi.nlm.nih.gov/36647078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,39982205,The acute and sub-chronic toxicological effects of 3-amino-9-ethylcarbazole (AEC) on zebrafish.,2025,10.1177/09603271251318968,https://pubmed.ncbi.nlm.nih.gov/39982205/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,41579708,Potential effects of bexarotene on neural development and function in zebrafish embryos.,2026,10.1016/j.biopha.2026.119050,https://pubmed.ncbi.nlm.nih.gov/41579708/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,38626605,Roxithromycin exposure induces motoneuron malformation and behavioral deficits of zebrafish by interfering with the differentiation of motor neuron progenitor cells.,2024,10.1016/j.ecoenv.2024.116327,https://pubmed.ncbi.nlm.nih.gov/38626605/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,39481820,Regeneration of zebrafish retina following toxic injury.,2024,10.1016/j.etap.2024.104582,https://pubmed.ncbi.nlm.nih.gov/39481820/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,38008201,4-Methylbenzylidene camphor induced neurobehavioral toxicity in zebrafish (Danio rerio) embryos.,2024,10.1016/j.envres.2023.117746,https://pubmed.ncbi.nlm.nih.gov/38008201/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,40490066,Co-exposure to triclosan and polystyrene nanoplastics on neurodevelopmental toxicity and gut microbiota dysbiosis in zebrafish (Danio rerio).,2025,10.1016/j.envpol.2025.126643,https://pubmed.ncbi.nlm.nih.gov/40490066/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,40172026,Effects of Glyphosate on Zebrafish (Danio rerio) Developmental Toxicity.,2025,10.1002/tox.24503,https://pubmed.ncbi.nlm.nih.gov/40172026/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,39612669,Effect of functional groups of polystyrene nanoplastics on the neurodevelopmental toxicity of acrylamide in the early life stage of zebrafish.,2025,10.1016/j.aquatox.2024.107177,https://pubmed.ncbi.nlm.nih.gov/39612669/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,38219622,"Astaxanthin activates the Nrf2/Keap1/HO-1 pathway to inhibit oxidative stress and ferroptosis, reducing triphenyl phosphate (TPhP)-induced neurodevelopmental toxicity.",2024,10.1016/j.ecoenv.2024.115960,https://pubmed.ncbi.nlm.nih.gov/38219622/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,37422240,Flubendazole exposure disrupts neural development and function of zebrafish embryos (Danio rerio).,2023,10.1016/j.scitotenv.2023.165376,https://pubmed.ncbi.nlm.nih.gov/37422240/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,37047130,Neurog1-Derived Peptides RMNE1 and DualPep-Shine Penetrate the Skin and Inhibit Melanin Synthesis by Regulating MITF Transcription.,2023,10.3390/ijms24076158,https://pubmed.ncbi.nlm.nih.gov/37047130/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,36423367,"Behavioral changes and transcriptomic effects at embryonic and post-embryonic stages reveal the toxic effects of 2,2',4,4'-tetrabromodiphenyl ether on neurodevelopment in zebrafish (Danio rerio).",2022,10.1016/j.ecoenv.2022.114310,https://pubmed.ncbi.nlm.nih.gov/36423367/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,38384198,Effects of low-dose ionizing radiation on the molecular pathways linking neurogenesis and autism spectrum disorders in zebrafish embryos.,2024,10.1080/01480545.2024.2318444,https://pubmed.ncbi.nlm.nih.gov/38384198/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,36682185,Nano-TiO2 aggravates bioaccumulation and developmental neurotoxicity of difenoconazole in zebrafish larvae via oxidative stress and apoptosis: Protective role of vitamin C.,2023,10.1016/j.ecoenv.2023.114554,https://pubmed.ncbi.nlm.nih.gov/36682185/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,38211790,Molecular interactions of paraben family of pollutants with embryonic neuronal proteins of Danio rerio: A step ahead in computational toxicity towards adverse outcome pathway.,2024,10.1016/j.chemosphere.2024.141155,https://pubmed.ncbi.nlm.nih.gov/38211790/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,38132138,Exploring the Functional Heterogeneity of Directly Reprogrammed Neural Stem Cell-Derived Neurons via Single-Cell RNA Sequencing.,2023,10.3390/cells12242818,https://pubmed.ncbi.nlm.nih.gov/38132138/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG1,ENSG00000181965,Neither,39007397,A large-scale CRISPR screen reveals context-specific genetic regulation of retinal ganglion cell regeneration.,2024,10.1242/dev.202754,https://pubmed.ncbi.nlm.nih.gov/39007397/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,38883158,Average values for real-time two and three-dimensional echocardiographic parameters of mitral and tricuspid valves in a healthy Iranian population.,2023,10.48305/arya.2023.24266,https://pubmed.ncbi.nlm.nih.gov/38883158/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,34621500,mRNA Network: Solution for Tracking Chemotherapy Insensitivity in Small-Cell Lung Cancer.,2021,10.1155/2021/2105176,https://pubmed.ncbi.nlm.nih.gov/34621500/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,36243213,Mediation by DNA methylation on the association of BMI and serum uric acid in Chinese monozygotic twins.,2023,10.1016/j.gene.2022.146957,https://pubmed.ncbi.nlm.nih.gov/36243213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,36795966,A Urine-based DNA Methylation Marker Test to Detect Upper Tract Urothelial Carcinoma: A Prospective Cohort Study.,2023,10.1097/ju.0000000000003188,https://pubmed.ncbi.nlm.nih.gov/36795966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,29168507,Orthogonal muscle fibres have different instructive roles in planarian regeneration.,2017,10.1038/nature24660,https://pubmed.ncbi.nlm.nih.gov/29168507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,29167762,LncRNA Expression in CD4+ T Cells in Neurosyphilis Patients.,2017,10.3389/fcimb.2017.00461,https://pubmed.ncbi.nlm.nih.gov/29167762/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,28588446,Purkinje Cell Degeneration and Motor Coordination Deficits in a New Mouse Model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay.,2017,10.3389/fnmol.2017.00121,https://pubmed.ncbi.nlm.nih.gov/28588446/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,21126319,Ablation of Sax2 gene expression prevents diet-induced obesity.,2011,10.1111/j.1742-4658.2010.07960.x,https://pubmed.ncbi.nlm.nih.gov/21126319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,17879320,Homeobox gene Sax2 deficiency causes an imbalance in energy homeostasis.,2007,10.1002/dvdy.21320,https://pubmed.ncbi.nlm.nih.gov/17879320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,26971308,Application of small angle X-ray scattering synchrotron technology for measuring ovine meat quality.,2016,10.1016/j.meatsci.2016.03.005,https://pubmed.ncbi.nlm.nih.gov/26971308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,14645517,Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation.,2003,10.1128/mcb.23.24.9046-9060.2003,https://pubmed.ncbi.nlm.nih.gov/14645517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,15183316,Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish.,2004,10.1016/j.modgep.2003.12.001,https://pubmed.ncbi.nlm.nih.gov/15183316/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,15647845,Identification of protein pattern in kidney cancer using ProteinChip arrays and bioinformatics.,2005,10.3892/ijmm.15.2.285,https://pubmed.ncbi.nlm.nih.gov/15647845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,18652358,[Changes of proteomic spectra of total flavones of Hippophae rhamnoides on myocardial protection].,2008,,https://pubmed.ncbi.nlm.nih.gov/18652358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,15211754,Tissue ischemia time affects gene and protein expression patterns within minutes following surgical tumor excision.,2004,10.2144/04366rr04,https://pubmed.ncbi.nlm.nih.gov/15211754/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,16112213,Analysis of differential protein expression in Acidithiobacillus ferrooxidans grown under different energy resources respectively using SELDI-ProteinChip technologies.,2006,10.1016/j.mimet.2005.06.006,https://pubmed.ncbi.nlm.nih.gov/16112213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,18203287,Discovering differential protein expression caused by CagA-induced ERK pathway activation in AGS cells using the SELDI-ProteinChip platform.,2008,10.3748/wjg.14.554,https://pubmed.ncbi.nlm.nih.gov/18203287/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,9271676,Linkage mapping of Sax2 to mouse chromosome 5.,1997,10.1007/s003359900541,https://pubmed.ncbi.nlm.nih.gov/9271676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,12461767,Proteomic analyses of arsenic-induced cell transformation with SELDI-TOF ProteinChip technology.,2003,10.1002/jcb.10356,https://pubmed.ncbi.nlm.nih.gov/12461767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,16941568,Mitochondrial protein patterns correlating with impaired insulin secretion from INS-1E cells exposed to elevated glucose concentrations.,2006,10.1002/pmic.200600137,https://pubmed.ncbi.nlm.nih.gov/16941568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,16423200,Proteomic study of plasma proteins in pregnant women with asthma.,2006,10.1111/j.1440-1843.2006.00782.x,https://pubmed.ncbi.nlm.nih.gov/16423200/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX1-1,ENSG00000235608,Neither,7518789,Identification of homeobox genes expressed in human haemopoietic progenitor cells.,1994,10.1016/0378-1119(94)90380-8,https://pubmed.ncbi.nlm.nih.gov/7518789/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-4,ENSG00000125816,Neither,41892358,Glycolytic Enzymes Are Part of an Oncogenic Network in AML.,2026,10.3390/cells15060569,https://pubmed.ncbi.nlm.nih.gov/41892358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-4,ENSG00000125816,Neither,41420251,Novel DNA methylation biomarkers in urine for non-invasive diagnosis of bladder urothelial carcinoma.,2025,10.1186/s13148-025-01964-3,https://pubmed.ncbi.nlm.nih.gov/41420251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-4,ENSG00000125816,Neither,40427364,Search for Ancient Selection Traces in Faverolle Chicken Breed (&lt;i&gt;Gallus gallus domesticus&lt;/i&gt;) Based on Runs of Homozygosity Analysis.,2025,10.3390/ani15101487,https://pubmed.ncbi.nlm.nih.gov/40427364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-4,ENSG00000125816,Neither,37492711,NK2 homeobox gene cluster: Functions and roles in human diseases.,2023,10.1016/j.gendis.2022.10.001,https://pubmed.ncbi.nlm.nih.gov/37492711/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-4,ENSG00000125816,Neither,34768865,NKL Homeobox Genes NKX2-3 and NKX2-4 Deregulate Megakaryocytic-Erythroid Cell Differentiation in AML.,2021,10.3390/ijms222111434,https://pubmed.ncbi.nlm.nih.gov/34768865/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-4,ENSG00000125816,Neither,41539636,"Guhan Yangsheng Jing alleviates sleep deprivation-induced neuronal injury via neurotransmitter rebalancing, mitochondrial protection, and inhibition of pyroptosis.",2026,10.1016/j.jep.2026.121209,https://pubmed.ncbi.nlm.nih.gov/41539636/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-4,ENSG00000125816,Neither,32851066,Transcriptome Profiling across Five Tissues of Giant Panda.,2020,10.1155/2020/3852586,https://pubmed.ncbi.nlm.nih.gov/32851066/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-4,ENSG00000125816,Neither,29294103,Brain-specific deletion of histone variant H2A.z results in cortical neurogenesis defects and neurodevelopmental disorder.,2018,10.1093/nar/gkx1295,https://pubmed.ncbi.nlm.nih.gov/29294103/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-4,ENSG00000125816,Neither,25051213,"Gene expression, function, and diversity of Nkx2-4 in the rainbow trout, Oncorhynchus mykiss.",2014,10.1016/j.ygcen.2014.07.007,https://pubmed.ncbi.nlm.nih.gov/25051213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-4,ENSG00000125816,Neither,36290187,Analysis of the Association of Two SNPs in the Promoter Regions of the PPP2R5C and SLC39A5 Genes with Litter Size in Yunshang Black Goats.,2022,10.3390/ani12202801,https://pubmed.ncbi.nlm.nih.gov/36290187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-4,ENSG00000125816,Neither,31447886,Novel Gene-Based Analysis of ASD GWAS: Insight Into the Biological Role of Associated Genes.,2019,10.3389/fgene.2019.00733,https://pubmed.ncbi.nlm.nih.gov/31447886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-4,ENSG00000125816,Neither,21692051,CpG island methylation profiling in human salivary gland adenoid cystic carcinoma.,2011,10.1002/cncr.25818,https://pubmed.ncbi.nlm.nih.gov/21692051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-4,ENSG00000125816,Neither,10960795,Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes.,2000,10.1016/s0925-4773(00)00400-7,https://pubmed.ncbi.nlm.nih.gov/10960795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-4,ENSG00000125816,Neither,22948044,Extensive molecular mapping of TCRα/δ- and TCRβ-involved chromosomal translocations reveals distinct mechanisms of oncogene activation in T-ALL.,2012,10.1182/blood-2012-04-425488,https://pubmed.ncbi.nlm.nih.gov/22948044/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,40272180,NLRP11 is required for canonical NLRP3 and non-canonical inflammasome activation during human macrophage infection with mycobacteria.,2025,10.1128/mbio.00818-25,https://pubmed.ncbi.nlm.nih.gov/40272180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,42533524,Phenylalanine coordinates antioxidant responses and ion homeostasis to enhance salinity tolerance in maize.,2026,10.1080/15592324.2026.2709225,https://pubmed.ncbi.nlm.nih.gov/42533524/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,40302809,Identification and Validation of Prognostic Genes Related to Histone Lactylation Modification in Glioblastoma: An Integrated Analysis of Transcriptome and Single-cell RNA Sequencing.,2025,10.7150/jca.110646,https://pubmed.ncbi.nlm.nih.gov/40302809/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,37424170,The NLRP11 Protein Bridges the Histone Lysine Acetyltransferase KAT7 to Acetylate Vimentin in the Early Stage of Lung Adenocarcinoma.,2023,10.1002/advs.202300971,https://pubmed.ncbi.nlm.nih.gov/37424170/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,39999035,A Tiered Approach to Exome Sequencing Analysis in Early-Onset Primary Ovarian Insufficiency.,2025,10.1210/clinem/dgaf124,https://pubmed.ncbi.nlm.nih.gov/39999035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,37478192,NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages.,2023,10.1126/sciimmunol.abo4767,https://pubmed.ncbi.nlm.nih.gov/37478192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,39351983,Molecular mechanisms of emerging inflammasome complexes and their activation and signaling in inflammation and pyroptosis.,2025,10.1111/imr.13406,https://pubmed.ncbi.nlm.nih.gov/39351983/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,35624206,NLRP3 licenses NLRP11 for inflammasome activation in human macrophages.,2022,10.1038/s41590-022-01220-3,https://pubmed.ncbi.nlm.nih.gov/35624206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,34054816,DDX3X Links NLRP11 to the Regulation of Type I Interferon Responses and NLRP3 Inflammasome Activation.,2021,10.3389/fimmu.2021.653883,https://pubmed.ncbi.nlm.nih.gov/34054816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,32832566,Adenosine-Induced NLRP11 in B Lymphoblasts Suppresses Human CD4+ T Helper Cell Responses.,2020,10.1155/2020/1421795,https://pubmed.ncbi.nlm.nih.gov/32832566/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,34721689,Identification and functional annotation of differentially expressed long noncoding RNAs in retinoblastoma.,2021,10.3892/etm.2021.10882,https://pubmed.ncbi.nlm.nih.gov/34721689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,29301940,The NLR family pyrin domain-containing 11 protein contributes to the regulation of inflammatory signaling.,2018,10.1074/jbc.ra117.000152,https://pubmed.ncbi.nlm.nih.gov/29301940/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,29215004,NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A.,2017,10.1038/s41467-017-02073-3,https://pubmed.ncbi.nlm.nih.gov/29215004/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,36099812,Genetic landscape of a large cohort of Primary Ovarian Insufficiency: New genes and pathways and implications for personalized medicine.,2022,10.1016/j.ebiom.2022.104246,https://pubmed.ncbi.nlm.nih.gov/36099812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,29097393,NLRP11 disrupts MAVS signalosome to inhibit type I interferon signaling and virus-induced apoptosis.,2017,10.15252/embr.201744480,https://pubmed.ncbi.nlm.nih.gov/29097393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,35150335,In silico bioinformatics analysis for identification of differentially expressed genes and therapeutic drug molecules in Glucocorticoid-resistant Multiple myeloma.,2022,10.1007/s12032-022-01651-w,https://pubmed.ncbi.nlm.nih.gov/35150335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,35789591,Fabrication and evaluation of electrospun polyacrylonitrile/silver nanofiber membranes for air filtration and antibacterial activity.,2023,10.1007/s00289-022-04311-1,https://pubmed.ncbi.nlm.nih.gov/35789591/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,29138264,Comprehensive investigation of cytokine- and immune-related gene variants in HBV-associated hepatocellular carcinoma patients.,2017,10.1042/bsr20171263,https://pubmed.ncbi.nlm.nih.gov/29138264/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,22267201,Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.,2012,10.1038/ng.1051,https://pubmed.ncbi.nlm.nih.gov/22267201/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP11,ENSG00000179873,Neither,21326309,De novo 19q13.42 duplications involving NLRP gene cluster in a patient with systemic-onset juvenile idiopathic arthritis.,2011,10.1038/jhg.2011.16,https://pubmed.ncbi.nlm.nih.gov/21326309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP8,ENSG00000179709,Neither,42468882,"PAN4, an AI-designed host-directed immunomodulatory peptide, promotes PGRP-SC1a-associated intestinal immune homeostasis in Drosophila melanogaster.",2026,10.1016/j.ibmb.2026.104635,https://pubmed.ncbi.nlm.nih.gov/42468882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP8,ENSG00000179709,Neither,40837069,Genome-Wide Association Study and Rare Variant Association Studies of Strabismus in the &lt;i&gt;All of Us&lt;/i&gt; Research Program.,2025,10.1016/j.xops.2025.100873,https://pubmed.ncbi.nlm.nih.gov/40837069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP8,ENSG00000179709,Neither,39165920,Novel 3D human trophoblast culture to explore &lt;i&gt;T. cruzi&lt;/i&gt; infection in the placenta.,2024,10.3389/fcimb.2024.1433424,https://pubmed.ncbi.nlm.nih.gov/39165920/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP8,ENSG00000179709,Neither,32194810,Systematic analysis of genetic variants in cancer-testis genes identified two novel lung cancer susceptibility loci in Chinese population.,2020,10.7150/jca.40002,https://pubmed.ncbi.nlm.nih.gov/32194810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP8,ENSG00000179709,Neither,36755464,Rare and low-frequency coding genetic variants contribute to pediatric-onset multiple sclerosis.,2023,10.1177/13524585221150736,https://pubmed.ncbi.nlm.nih.gov/36755464/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP8,ENSG00000179709,Neither,31601004,Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD).,2019,10.3390/genes10100783,https://pubmed.ncbi.nlm.nih.gov/31601004/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP8,ENSG00000179709,Neither,32226298,Nucleotide binding domain and leucine-rich repeat pyrin domain-containing protein 12: characterization of its binding to hematopoietic cell kinase.,2020,10.7150/ijbs.41798,https://pubmed.ncbi.nlm.nih.gov/32226298/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP8,ENSG00000179709,Neither,30789912,Extracellular vesicles of Trypanosoma cruzi tissue-culture cell-derived trypomastigotes: Induction of physiological changes in non-parasitized culture cells.,2019,10.1371/journal.pntd.0007163,https://pubmed.ncbi.nlm.nih.gov/30789912/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP8,ENSG00000179709,Neither,28095655,Production of IL-1β and Inflammasome with Up-Regulated Expressions of NOD-Like Receptor Related Genes in Toxoplasma gondii-Infected THP-1 Macrophages.,2016,10.3347/kjp.2016.54.6.711,https://pubmed.ncbi.nlm.nih.gov/28095655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP8,ENSG00000179709,Neither,16339045,"Bovine NALP5, NALP8, and NALP9 genes: assignment to a QTL region and the expression in adult tissues, oocytes, and preimplantation embryos.",2006,10.1095/biolreprod.105.045096,https://pubmed.ncbi.nlm.nih.gov/16339045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP8,ENSG00000179709,Neither,26674416,Transcriptional and phenotypical heterogeneity of Trypanosoma cruzi cell populations.,2015,10.1098/rsob.150190,https://pubmed.ncbi.nlm.nih.gov/26674416/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP8,ENSG00000179709,Neither,22025509,Conserved regions as markers of different patterns of expression and distribution of the mucin-associated surface proteins of Trypanosoma cruzi.,2012,10.1128/iai.05859-11,https://pubmed.ncbi.nlm.nih.gov/22025509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,42198749,NLR Inflammasomes in Viral Infections: From Molecular Mechanisms to Therapeutic Interventions.,2026,10.3390/v18050546,https://pubmed.ncbi.nlm.nih.gov/42198749/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,41062723,Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns.,2025,10.1038/s41423-025-01354-y,https://pubmed.ncbi.nlm.nih.gov/41062723/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,40191489,Genetic Markers of Spina Bifida: Enrichment of Pathogenic Variants and Variants of Uncertain Significance.,2025,10.4103/jiaps.jiaps_193_24,https://pubmed.ncbi.nlm.nih.gov/40191489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,41753558,Role of Nod-like Receptors in &lt;i&gt;Helicobacter pylori&lt;/i&gt; Infection: Insights into Innate Immune Signaling Pathways.,2026,10.3390/microorganisms14020271,https://pubmed.ncbi.nlm.nih.gov/41753558/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,40922363,Genetic regulation of lipid metabolism in Han Chinese adolescents from Xinjiang: An extreme phenotype sequencing approach.,2025,10.1097/md.0000000000043825,https://pubmed.ncbi.nlm.nih.gov/40922363/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,40678382,Genome-wide association and functional annotation analyses reveal candidate genes and pathways associated with various ewe longevity indicators in U.S. Katahdin sheep.,2025,10.3389/fgene.2025.1600587,https://pubmed.ncbi.nlm.nih.gov/40678382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,39351983,Molecular mechanisms of emerging inflammasome complexes and their activation and signaling in inflammation and pyroptosis.,2025,10.1111/imr.13406,https://pubmed.ncbi.nlm.nih.gov/39351983/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,37473827,NLRP9 involved in antiviral innate immunity via binding VIM in IPEC-J2 cells.,2023,10.1016/j.dci.2023.104895,https://pubmed.ncbi.nlm.nih.gov/37473827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,37155429,Expression Profile of Pyroptosis-Related Genes and the Associated Regulatory Axis in Primary Gout Patients.,2023,10.2147/jir.s407359,https://pubmed.ncbi.nlm.nih.gov/37155429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,38644450,NLRP inflammasomes in health and disease.,2024,10.1186/s43556-024-00179-x,https://pubmed.ncbi.nlm.nih.gov/38644450/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,37155030,In silico analysis and molecular docking studies of natural compounds of Withania somnifera against bovine NLRP9.,2023,10.1007/s00894-023-05570-z,https://pubmed.ncbi.nlm.nih.gov/37155030/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,34257569,Somatic Mutation of NLRP Genes in Gastric and Colonic Cancers.,2021,10.3389/pore.2021.607385,https://pubmed.ncbi.nlm.nih.gov/34257569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,32399794,Maternally contributed Nlrp9b expressed in human and mouse ovarian follicles contributes to early murine preimplantation development.,2020,10.1007/s10815-020-01767-w,https://pubmed.ncbi.nlm.nih.gov/32399794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,34782712,Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.,2022,10.1038/s41380-021-01379-5,https://pubmed.ncbi.nlm.nih.gov/34782712/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,35138947,Innate Sensors Trigger Regulated Cell Death to Combat Intracellular Infection.,2022,10.1146/annurev-immunol-101320-011235,https://pubmed.ncbi.nlm.nih.gov/35138947/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,36188246,Construction of a Prognosis Model of the Pyroptosis-Related Gene in Multiple Myeloma and Screening of Core Genes.,2022,10.1021/acsomega.2c04212,https://pubmed.ncbi.nlm.nih.gov/36188246/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,32413845,Involvement of Nlrp9a/b/c in mouse preimplantation development.,2020,10.1530/rep-19-0516,https://pubmed.ncbi.nlm.nih.gov/32413845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,30217166,Exome sequencing study in patients with multiple sclerosis reveals variants associated with disease course.,2018,10.1186/s12974-018-1307-1,https://pubmed.ncbi.nlm.nih.gov/30217166/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,36685920,Genome-wide exploration of a pyroptosis-related gene module along with immune cell infiltration patterns in bronchopulmonary dysplasia.,2022,10.3389/fgene.2022.1074723,https://pubmed.ncbi.nlm.nih.gov/36685920/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,32735703,The mysterious role of the NLRP9 pyrin domain in inflammasome assembly.,2020,10.1002/1873-3468.13889,https://pubmed.ncbi.nlm.nih.gov/32735703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,40612489,Comparing machine learning models with a focus on tone in grooming chat logs.,2025,10.3389/fped.2025.1591828,https://pubmed.ncbi.nlm.nih.gov/40612489/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,39675680,Clinical response and corresponding blood transcriptome pathways before and after treatment of hereditary angioedema prodromes compared to active swelling attacks.,2025,10.1016/j.jaci.2024.11.035,https://pubmed.ncbi.nlm.nih.gov/39675680/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,28888400,Characterization of inflammasome-related genes in urine sediments of patients receiving intravesical BCG therapy.,2017,10.1016/j.urolonc.2017.08.004,https://pubmed.ncbi.nlm.nih.gov/28888400/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,35459784,Genetic susceptibility to patient-reported xerostomia among long-term oropharyngeal cancer survivors.,2022,10.1038/s41598-022-10538-9,https://pubmed.ncbi.nlm.nih.gov/35459784/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,28579804,Expression of urinary miRNAs targeting NLRs inflammasomes in bladder cancer.,2017,10.2147/ott.s132680,https://pubmed.ncbi.nlm.nih.gov/28579804/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,24901306,The NOD-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer: a case-control study and gene expression analyses.,2014,10.1371/journal.pone.0098899,https://pubmed.ncbi.nlm.nih.gov/24901306/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,28636595,Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells.,2017,10.1038/nature22967,https://pubmed.ncbi.nlm.nih.gov/28636595/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP9,ENSG00000185792,Neither,28432035,Expression of pattern recognition receptors and activation of the non-canonical inflammasome pathway in brain pericytes.,2017,10.1016/j.bbi.2017.04.010,https://pubmed.ncbi.nlm.nih.gov/28432035/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,41257985,Neuromedin B drives goat granulosa cell proliferation via NMBR-mediated calcium homeostasis.,2025,10.1186/s13048-025-01844-7,https://pubmed.ncbi.nlm.nih.gov/41257985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,40553099,Sigh generation in preBötzinger complex.,2025,10.7554/elife.100192,https://pubmed.ncbi.nlm.nih.gov/40553099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,41242095,Neuromedin B and its receptor NMBR inhibit H9N2 infection.,2026,10.1016/j.vetmic.2025.110790,https://pubmed.ncbi.nlm.nih.gov/41242095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,41339365,Whole-exome sequencing and burden analysis identify six novel candidate risk genes and expand the genetic landscape of Parkinson's disease.,2025,10.1038/s41531-025-01195-6,https://pubmed.ncbi.nlm.nih.gov/41339365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,41424583,Bioinformatics Analysis of Hypoxia-Related Mechanisms in Endometriosis: DDR2 as a Potential Diagnostic and Therapeutic Biomarker.,2025,10.1155/bmri/4765791,https://pubmed.ncbi.nlm.nih.gov/41424583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,41007372,"Gastrin-Releasing Peptide Receptors Stimulate MAPK-Mediated Growth of Lung Cancer Cells by Transactivating HER4 in a Neuregulin-1, MAP Kinase-Dependent Manner Requiring Activation of the ROS-System.",2025,10.3390/biology14091225,https://pubmed.ncbi.nlm.nih.gov/41007372/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,40001922,Identification of DNA Methylation Differences in Pituitary Tissues of Sichuan White Geese Using Whole-Genome Bisulfite Sequencing (WGBS).,2025,10.3390/biology14020154,https://pubmed.ncbi.nlm.nih.gov/40001922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,42446686,Discovery of a Potent Small Molecule Antagonist of GRPR for the Treatment of Pruritus.,2026,10.1007/s00044-026-03566-x,https://pubmed.ncbi.nlm.nih.gov/42446686/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,39716597,Blockade of PVN neuromedin B receptor alleviates inflammation via the RAS/ROS/NF-κB pathway in spontaneously hypertensive rats.,2025,10.1016/j.brainresbull.2024.111180,https://pubmed.ncbi.nlm.nih.gov/39716597/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,41672935,Interaction between a refined carbohydrate dietary pattern and genetic risk score for obesity in the Korean population.,2026,10.1017/s136898002610202x,https://pubmed.ncbi.nlm.nih.gov/41672935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,39214988,Cervical cancer-produced neuromedin-B reprograms Schwann cells to initiate perineural invasion.,2024,10.1038/s41419-024-07030-9,https://pubmed.ncbi.nlm.nih.gov/39214988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,37642928,Neuromedin B receptor as a potential therapeutic target for corticotroph adenomas.,2023,10.1007/s11102-023-01350-3,https://pubmed.ncbi.nlm.nih.gov/37642928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,35189108,Functional roles of neuromedin B and gastrin-releasing peptide in regulating itch and pain in the spinal cord of non-human primates.,2022,10.1016/j.bcp.2022.114972,https://pubmed.ncbi.nlm.nih.gov/35189108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,34919054,BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk.,2021,10.7554/elife.71689,https://pubmed.ncbi.nlm.nih.gov/34919054/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,37197194,Identification of Sex-Specific Genetic Polymorphisms Associated with Asthma in Middle-Aged and Older Canadian Adults: An Analysis of CLSA Data.,2023,10.2147/jaa.s404670,https://pubmed.ncbi.nlm.nih.gov/37197194/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,34646374,Neuromedin B receptor stimulation of Cav3.2 T-type Ca2+ channels in primary sensory neurons mediates peripheral pain hypersensitivity.,2021,10.7150/thno.62255,https://pubmed.ncbi.nlm.nih.gov/34646374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,36095918,Effect of NMB-regulated ERK1/2 and p65 signaling pathway on proliferation and apoptosis of cervical cancer.,2022,10.1016/j.prp.2022.154104,https://pubmed.ncbi.nlm.nih.gov/36095918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,34986325,Glutamate in primary afferents is required for itch transmission.,2022,10.1016/j.neuron.2021.12.007,https://pubmed.ncbi.nlm.nih.gov/34986325/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,39851499,"Synthetic CB1 Cannabinoids Promote Tunneling Nanotube Communication, Cellular Migration, and Epithelial-Mesenchymal Transition in Pancreatic PANC-1 and Colorectal SW-620 Cancer Cell Lines.",2025,10.3390/cells14020071,https://pubmed.ncbi.nlm.nih.gov/39851499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,32699178,Neuromedin B receptor mediates neuromedin B-induced COX-2 and IL-6 expression in human primary myometrial cells.,2020,10.1136/jim-2020-001412,https://pubmed.ncbi.nlm.nih.gov/32699178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,31724192,Impact of natural neuromedin-B receptor variants on iron metabolism.,2020,10.1002/ajh.25679,https://pubmed.ncbi.nlm.nih.gov/31724192/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,28780306,Neuromedin B and its receptor silencing suppresses osteoclast generation by modulating precursor proliferation via M-CSF/c-Fms/D-type cyclins.,2017,10.1016/j.yexcr.2017.08.003,https://pubmed.ncbi.nlm.nih.gov/28780306/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,32349388,Integrative Transcriptome Analyses of the Human Fallopian Tube: Fimbria and Ampulla-Site of Origin of Serous Carcinoma of the Ovary.,2020,10.3390/cancers12051090,https://pubmed.ncbi.nlm.nih.gov/32349388/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,23826298,Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice.,2013,10.1371/journal.pone.0067422,https://pubmed.ncbi.nlm.nih.gov/23826298/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,29321614,Effects on metabolic parameters in young rats born with low birth weight after exposure to a mixture of pesticides.,2018,10.1038/s41598-017-18626-x,https://pubmed.ncbi.nlm.nih.gov/29321614/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,18975117,"In vitro binding evaluation of 177Lu-AMBA, a novel 177Lu-labeled GRP-R agonist for systemic radiotherapy in human tissues.",2009,10.1007/s10585-008-9220-0,https://pubmed.ncbi.nlm.nih.gov/18975117/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,21060863,"Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.",2010,10.1371/journal.pgen.1001184,https://pubmed.ncbi.nlm.nih.gov/21060863/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMBR,ENSG00000135577,Neither,20736409,Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.,2010,10.1074/mcp.m110.001719,https://pubmed.ncbi.nlm.nih.gov/20736409/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42474276,"Targeted β-Glucan-Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis-Associated Gut Microbiota and Alleviates Ulcerative Colitis-Associated Anxiety, Depression, and Neuropsychiatric Behaviors.",2026,10.1002/advs.76566,https://pubmed.ncbi.nlm.nih.gov/42474276/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42770276,Biomarkers of brain injury in foals with neonatal maladjustment syndrome.,2026,10.1093/jvimsj/aalag228,https://pubmed.ncbi.nlm.nih.gov/42770276/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,41937268,The Transcription Factors Six3 and Six6 in Neuromedin-S Neurons Differentially Affect Circadian Rhythms.,2026,10.1002/jnr.70123,https://pubmed.ncbi.nlm.nih.gov/41937268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42646429,Nanotoxicology: Emerging Challenges and Future Solutions for Safe Nanomaterial Applications.,2026,10.3390/nano16161020,https://pubmed.ncbi.nlm.nih.gov/42646429/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42871215,Correlation of peripheral blood &lt;i&gt;BMAL1&lt;/i&gt; level with non-motor symptoms in Parkinson's disease patients.,2026,10.3389/fneur.2026.1962167,https://pubmed.ncbi.nlm.nih.gov/42871215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42741663,Disruption of prefrontal and superior temporal gyrus white matter networks in antipsychotic-treated schizophrenia with comorbid metabolic syndrome.,2026,10.3389/fpsyt.2026.1878935,https://pubmed.ncbi.nlm.nih.gov/42741663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42621783,Inorganic Nanomaterials can Promote or Inhibit Tumor Metastasis Depending on Tumor Microenvironment Composition.,2026,10.1002/advs.77310,https://pubmed.ncbi.nlm.nih.gov/42621783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42158647,Transcriptome profile analysis of genes by RNA-sequencing in neonatal maternal separation rats with autistic-like behaviors.,2026,10.21037/tp-2026-1-0002,https://pubmed.ncbi.nlm.nih.gov/42158647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42556436,Pramipexole alleviates non-motor symptoms and autophagy-related protein abnormalities in a dual neurotoxin Parkinson's disease model.,2026,10.1016/j.brainresbull.2026.112072,https://pubmed.ncbi.nlm.nih.gov/42556436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42005707,Bidirectional Interactions Between Nanomaterials and Extracellular Vesicles: Molecular Insights and Translational Implications.,2026,10.2147/ijn.s585732,https://pubmed.ncbi.nlm.nih.gov/42005707/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42807138,Current concepts review: Low-vs high-tone neuromuscular spinal deformities: An evolving distinction with clinical implications.,2026,10.1177/18632521261492971,https://pubmed.ncbi.nlm.nih.gov/42807138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42755624,Case Report: Paralytic ileus as an early manifestation of evolving neuroleptic malignant syndrome in a patient receiving anti-psychotics.,2026,10.3389/fmed.2026.1911402,https://pubmed.ncbi.nlm.nih.gov/42755624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,41620392,Early life stress and disruption of the ageing trajectory in female rats: Insights into the origins and mechanisms underlying the risk of hypertension.,2026,10.1113/ep093539,https://pubmed.ncbi.nlm.nih.gov/41620392/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,41008972,The Dual Role of Nanomaterials in Ovarian Cancer and Female Fertility as Anti- and Prooxidants.,2025,10.3390/antiox14091066,https://pubmed.ncbi.nlm.nih.gov/41008972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42649220,Oligomeric Alpha-Synuclein from neural-derived extracellular vesicles as possible biomarkers of non-motor symptoms in Parkinson's disease.,2026,10.1038/s41531-026-01474-w,https://pubmed.ncbi.nlm.nih.gov/42649220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42741587,Performance trade-offs between dense prediction and sparse query mechanisms for brain tumor MRI detection: a comparative study of YOLOv8 and RT-DETR.,2026,10.3389/fmed.2026.1905061,https://pubmed.ncbi.nlm.nih.gov/42741587/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42255497,Identification of genes associated with smell dysfunction in Parkinson's disease.,2026,10.1016/j.prdoa.2026.100453,https://pubmed.ncbi.nlm.nih.gov/42255497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42160361,Handgrip strength and relationship with non-motor symptoms in Parkinson's disease.,2026,10.1177/1877718x251340585,https://pubmed.ncbi.nlm.nih.gov/42160361/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42449393,Neuroleptic malignant syndrome precipitated by chlorpromazine: a case report.,2026,10.1186/s13256-026-06373-5,https://pubmed.ncbi.nlm.nih.gov/42449393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,41368641,Bacteroides ovatus-derived N-methylserotonin inhibit colorectal cancer via the HTR1D-mediated cAMP-PKA-NF-κB signaling axis.,2025,10.3389/fimmu.2025.1696701,https://pubmed.ncbi.nlm.nih.gov/41368641/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,41201063,The Immune Microenvironment in Liver Cancer: From Analysis to Targeting.,2025,10.1002/advs.202518487,https://pubmed.ncbi.nlm.nih.gov/41201063/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42561466,Ecotoxicity assessment of magnetic trimethyl chitosan nanomaterials for the treatment of glyphosate- and AMPA-contaminated water.,2026,10.1016/j.aquatox.2026.107968,https://pubmed.ncbi.nlm.nih.gov/42561466/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42704393,Potential toxicity of nanomaterials on rats/mice: a meta-analysis.,2026,10.1007/s10653-026-03473-5,https://pubmed.ncbi.nlm.nih.gov/42704393/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42537963,Quercetin-carboxymethyl chitosan‑hydrogen nanomicelles for the treatment of chemotherapy induced oral mucositis in mice.,2026,10.1016/j.ijbiomac.2026.153863,https://pubmed.ncbi.nlm.nih.gov/42537963/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42494136,Key Safety Criteria for Novel Microbial Food Ingredients: A Comparative Analysis of International Regulatory Frameworks.,2026,10.4014/jmb.2605.05032,https://pubmed.ncbi.nlm.nih.gov/42494136/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,41581130,"Review on nanotoxicology and nano-bio interactions: influencing factors, assessment methods, mechanisms, and applications.",2026,10.1093/etojnl/vgag019,https://pubmed.ncbi.nlm.nih.gov/41581130/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,41552604,Progress of Palladium Nanomaterials for Tumor Diagnosis and Therapy.,2026,10.1021/acsomega.5c08165,https://pubmed.ncbi.nlm.nih.gov/41552604/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42738652,Carrier-Assisted Nanomaterials and Microbial Dynamics in Advanced Wastewater Treatment: A Review.,2026,10.3390/molecules31172991,https://pubmed.ncbi.nlm.nih.gov/42738652/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,40933734,Advancements of algae-involved cancer treatment.,2025,10.52601/bpr.2024.240055,https://pubmed.ncbi.nlm.nih.gov/40933734/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42409530,"Exploring the potential of green nanomaterials: An ecofriendly approach for sustainable agriculture, food safety and environmental pollution control.",2026,10.1016/j.foodres.2026.119588,https://pubmed.ncbi.nlm.nih.gov/42409530/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,41190217,Nanomaterial-Driven Regulated Cell Death: Mechanistic Insights and Novel Strategies for Tumor Therapy.,2025,10.2147/ijn.s558103,https://pubmed.ncbi.nlm.nih.gov/41190217/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,41884277,"Cardiotoxicity Challenges in Nanomaterial: Risk Assessment, Mechanisms, and Mitigation Strategies.",2026,10.2147/ijn.s595349,https://pubmed.ncbi.nlm.nih.gov/41884277/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42563548,Cannabis-Based Oil for Pain and Other Non-Motor Symptoms in Parkinson's Disease: A Randomized Controlled Trial.,2026,10.1002/mds.70449,https://pubmed.ncbi.nlm.nih.gov/42563548/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,41777427,"Survival of patients with colorectal or pancreatic cancer who received &lt;i&gt;UGT1A1&lt;/i&gt; genotype-guided dosing of irinotecan in the Netherlands (2017-2024): a retrospective, multicentre cohort study.",2026,10.1016/j.lanepe.2026.101629,https://pubmed.ncbi.nlm.nih.gov/41777427/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42276133,Real-World Impact of UGT1A1 Genotype-Guided Irinotecan Dosing on Severe Toxicity and Hospitalization: A Multicenter Study.,2026,10.6004/jnccn.2026.7011,https://pubmed.ncbi.nlm.nih.gov/42276133/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42231917,A Janus polydopamine nanomotor hydrogel enables enhanced tumor penetration and potent synergistic photothermal-photodynamic therapy.,2026,10.1016/j.mtbio.2026.103237,https://pubmed.ncbi.nlm.nih.gov/42231917/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NMS,ENSG00000204640,Neither,42496039,The Plant-to-Plant Circular Strategy: Coupling Photodegradation and Phytoremediation With Plant-Based Nanomaterials for Plastic Degradation.,2026,10.1002/advs.76789,https://pubmed.ncbi.nlm.nih.gov/42496039/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,41524225,USP9X as a Candidate Mediator of Prenatal Aspirin-Induced Ovarian Reserve Reduction in Offspring Mice.,2026,10.1002/advs.202507679,https://pubmed.ncbi.nlm.nih.gov/41524225/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,39871066,Oocyte/zygote/embryo maturation arrest: a clinical study expanding the phenotype of NOBOX variants.,2025,10.1007/s10815-025-03402-y,https://pubmed.ncbi.nlm.nih.gov/39871066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,41324758,Primary ovarian insufficiency due to homozygous variants in the homeobox transcription factor NOBOX.,2025,10.1007/s11033-025-11252-1,https://pubmed.ncbi.nlm.nih.gov/41324758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,42907457,Single-cell TimeLapse-seq reveals MTA is an essential retrotransposon orchestrating mouse zygotic genome activation.,2026,10.1038/s41467-026-77750-3,https://pubmed.ncbi.nlm.nih.gov/42907457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,40246288,Reclassifying NOBOX variants in primary ovarian insufficiency cases with a corrected gene model and a novel quantitative framework.,2025,10.1093/humrep/deaf058,https://pubmed.ncbi.nlm.nih.gov/40246288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,37990081,Genetic evidence for differential functions of figla and nobox in zebrafish ovarian differentiation and folliculogenesis.,2023,10.1038/s42003-023-05551-1,https://pubmed.ncbi.nlm.nih.gov/37990081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,42289696,"Stage-, dose- and course-dependent disruption of mice fetal ovarian development following prenatal dexamethasone exposure.",2026,10.1186/s13048-026-02158-y,https://pubmed.ncbi.nlm.nih.gov/42289696/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,39223676,Whole-genome de novo sequencing reveals genomic variants associated with differences of sex development in SRY negative pigs.,2024,10.1186/s13293-024-00644-w,https://pubmed.ncbi.nlm.nih.gov/39223676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,41850064,"Integrated transcriptomic, proteomic, and metabolomic analyses reveal molecular mechanisms underlying clutch length differences in goose ovaries.",2026,10.1016/j.psj.2026.106731,https://pubmed.ncbi.nlm.nih.gov/41850064/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,41393291,Novel variants associated with premature ovarian insufficiency in Russian adolescents.,2025,10.3389/fendo.2025.1687148,https://pubmed.ncbi.nlm.nih.gov/41393291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,41588333,Integrated analysis of lncRNA-miRNA-mRNA networks reveals stage-specific molecular regulation of oogenesis in Chinese alligator (Alligator sinensis).,2026,10.1186/s12864-026-12542-z,https://pubmed.ncbi.nlm.nih.gov/41588333/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,42034223,Embryonic stem cell-derived extracellular vesicles alleviate ovarian dysfunction.,2026,10.1016/j.mad.2026.112186,https://pubmed.ncbi.nlm.nih.gov/42034223/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,38523712,Association between polymorphisms in NOBOX and litter size traits in Xiangsu pigs.,2024,10.3389/fvets.2024.1359312,https://pubmed.ncbi.nlm.nih.gov/38523712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,41946196,Early fetal sex identification in the Piau pig breed using Y chromosome-linked transcripts.,2026,10.1016/j.domaniend.2026.107014,https://pubmed.ncbi.nlm.nih.gov/41946196/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,39983089,Perfluorobutanesulfonate Induces Hypothalamic-Pituitary-Gonadal Axis Disruption and Gonadal Dysplasia of Lithobates catesbeianus Tadpoles.,2025,10.1021/acs.chemrestox.4c00498,https://pubmed.ncbi.nlm.nih.gov/39983089/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,40696273,"The impact of prenatal amoxicillin exposure at different doses, stages, and courses on offspring ovarian development.",2025,10.1186/s10020-025-01322-2,https://pubmed.ncbi.nlm.nih.gov/40696273/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,36607631,Sumoylation regulates functional properties of the oocyte transcription factors SOHLH1 and NOBOX.,2023,10.1096/fj.202201481r,https://pubmed.ncbi.nlm.nih.gov/36607631/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,37921973,NOBOX gene variants in premature ovarian insufficiency: ethnicity-dependent insights.,2024,10.1007/s10815-023-02981-y,https://pubmed.ncbi.nlm.nih.gov/37921973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,35157068,Loss of Nobox prevents ovarian differentiation from juvenile ovaries in zebrafish.,2022,10.1093/biolre/ioac036,https://pubmed.ncbi.nlm.nih.gov/35157068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,38092955,Publisher Correction: Genetic evidence for differential functions of figla and nobox in zebrafish ovarian differentiation and folliculogenesis.,2023,10.1038/s42003-023-05651-y,https://pubmed.ncbi.nlm.nih.gov/38092955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,38657942,"Prenatal acetaminophen exposure and the developing ovary: Time, dose, and course consequences for fetal mice.",2024,10.1016/j.fct.2024.114679,https://pubmed.ncbi.nlm.nih.gov/38657942/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,37194006,Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice.,2023,10.1186/s12958-023-01097-3,https://pubmed.ncbi.nlm.nih.gov/37194006/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,35912926,Modulatory effects of concomitant quercetin/sitagliptin administration on the ovarian histological and biochemical alterations provoked by doxorubicin in a streptozotocin-induced diabetic rat model.,2023,10.1080/01478885.2022.2105481,https://pubmed.ncbi.nlm.nih.gov/35912926/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,38593938,Perinatal bisphenol S exposure exacerbates the oxidative burden and apoptosis in neonatal ovaries by suppressing the mTOR/autophagy axis.,2024,10.1016/j.envpol.2024.123939,https://pubmed.ncbi.nlm.nih.gov/38593938/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,34480423,Compound heterozygous null mutations of NOBOX in sisters with delayed puberty and primary amenorrhea.,2021,10.1002/mgg3.1776,https://pubmed.ncbi.nlm.nih.gov/34480423/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,36303648,Irinotecan (CPT-11) Treatment Induces Mild Gonadotoxicity.,2022,10.3389/frph.2022.812053,https://pubmed.ncbi.nlm.nih.gov/36303648/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,38205005,"Gene-Level Analysis of Anthracycline-Induced Cardiomyopathy in Cancer Survivors: A Report From COG-ALTE03N1, BMTSS, and CCSS.",2023,10.1016/j.jaccao.2023.06.007,https://pubmed.ncbi.nlm.nih.gov/38205005/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,28743298,"R-spondin2, a novel target of NOBOX: identification of variants in a cohort of women with primary ovarian insufficiency.",2017,10.1186/s13048-017-0345-0,https://pubmed.ncbi.nlm.nih.gov/28743298/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,34639162,Transcriptome Analyses Identify Potential Key microRNAs and Their Target Genes Contributing to Ovarian Reserve.,2021,10.3390/ijms221910819,https://pubmed.ncbi.nlm.nih.gov/34639162/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,29047400,Observation of the influences of diosgenin on aging ovarian reserve and function in a mouse model.,2017,10.1186/s40001-017-0285-6,https://pubmed.ncbi.nlm.nih.gov/29047400/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,26053026,Adverse Effects of High Concentrations of Fluoride on Characteristics of the Ovary and Mature Oocyte of Mouse.,2015,10.1371/journal.pone.0129594,https://pubmed.ncbi.nlm.nih.gov/26053026/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,23463338,Intraovarian transplantation of primordial follicles fails to rescue chemotherapy injured ovaries.,2013,10.1038/srep01384,https://pubmed.ncbi.nlm.nih.gov/23463338/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,21722721,Maternal exposure to fenarimol promotes reproductive performance in mouse offspring.,2011,10.1016/j.toxlet.2011.05.1040,https://pubmed.ncbi.nlm.nih.gov/21722721/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,24879098,Skin-derived mesenchymal stem cells help restore function to ovaries in a premature ovarian failure mouse model.,2014,10.1371/journal.pone.0098749,https://pubmed.ncbi.nlm.nih.gov/24879098/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,26243799,Genetics of primary ovarian insufficiency: new developments and opportunities.,2015,10.1093/humupd/dmv036,https://pubmed.ncbi.nlm.nih.gov/26243799/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,24939957,Identification of a duplication within the GDF9 gene and novel candidate genes for primary ovarian insufficiency (POI) by a customized high-resolution array comparative genomic hybridization platform.,2014,10.1093/humrep/deu149,https://pubmed.ncbi.nlm.nih.gov/24939957/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOBOX,ENSG00000106410,Neither,16597639,cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles.,2006,10.1093/molehr/gal035,https://pubmed.ncbi.nlm.nih.gov/16597639/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,42727851,F-actin-dependent activation of NADPH oxidase 5 by the vacuolar-type ATPase.,2026,10.1016/j.jbc.2026.113546,https://pubmed.ncbi.nlm.nih.gov/42727851/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,42013548,Single-Cell sequencing investigation of endoplasmic reticulum stress-related genes in gastric cancer prognostic models and identification of NOX5 as a novel therapeutic target.,2026,10.1016/j.tranon.2026.102780,https://pubmed.ncbi.nlm.nih.gov/42013548/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,41752014,Role of NADPH Oxidases as Novel Therapeutic Targets for the Impaired Neurovascular Unit in the Early Stage of Diabetic Retinopathy.,2026,10.3390/ijms27041879,https://pubmed.ncbi.nlm.nih.gov/41752014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,42911736,Simplification and Derivatization of Quinoline-Containing M41 Lead to the Discovery of NADPH Oxidase Isoform-Selective Inhibitors Effective in Cancer Cells.,2026,10.1021/acs.jmedchem.6c02029,https://pubmed.ncbi.nlm.nih.gov/42911736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,42741636,"Molecular Striptease of a Thiadiazolopyrimidine Hit Yields a Streamlined, Artifact-Free NADPH Mimic for NOX Inhibition.",2026,10.1021/acsmedchemlett.6c00370,https://pubmed.ncbi.nlm.nih.gov/42741636/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,42337877,Disrupting Redox Balance: A Redox-Based Strategy to Combat Temozolomide Resistance in Glioblastoma.,2026,10.2174/0118715206470620260527200257,https://pubmed.ncbi.nlm.nih.gov/42337877/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,42822740,Involvement of LTC4 and NADPH oxidase 5 in extracellular trap formation in Ruditapes philippinarum.,2026,10.1016/j.fsi.2026.111758,https://pubmed.ncbi.nlm.nih.gov/42822740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,41672379,NADPH oxidase 5 promotes adhesion and infiltration of immune cells in the brain. Implications in ischemic stroke.,2026,10.1016/j.bbadis.2026.168188,https://pubmed.ncbi.nlm.nih.gov/41672379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,41912523,Synaptic rescue in an Alzheimer's mouse model: low-temperature steam-derived black ginseng oligosaccharides remodel protein S-nitrosylation-NADPH oxidase axis.,2026,10.1038/s41538-026-00812-9,https://pubmed.ncbi.nlm.nih.gov/41912523/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,39830324,Association of NOX5 Expression with Sperm Activity and Motility in Pathospermic Infertile Men.,2024,10.18502/jri.v25i3.17012,https://pubmed.ncbi.nlm.nih.gov/39830324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,42814264,An Early Value Assessment of Biomarker-Guided Precision Medicine for Treatment-Resistant Hypertension: A Headroom and Threshold Analysis.,2026,10.1007/s40258-026-01075-x,https://pubmed.ncbi.nlm.nih.gov/42814264/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,42651958,"Dietary Chlorogenic Acid Attenuates Liver Injury, Lipid Metabolic Disturbance, and Inflammatory Responses in Broilers Under High Stocking Density.",2026,10.3390/ani16162552,https://pubmed.ncbi.nlm.nih.gov/42651958/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,42123404,Molecular Advances in Male Infertility and Fertility: Importance of Redox Regulation and Oxidative Stress.,2026,10.3390/ijms27093819,https://pubmed.ncbi.nlm.nih.gov/42123404/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,37821487,A novel monoclonal antibody reveals the enrichment of NADPH oxidase 5 in human splenic endothelial cells.,2023,10.1038/s41598-023-44018-5,https://pubmed.ncbi.nlm.nih.gov/37821487/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,41406706,N&lt;sup&gt;ε&lt;/sup&gt;-(carboxymethyl)lysine-modified albumin exacerbates doxorubicin-induced NOX5-dependent oxidative stress in endothelial cells.,2026,10.1016/j.bbrc.2025.153135,https://pubmed.ncbi.nlm.nih.gov/41406706/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,36905456,"Structure, regulation, and physiological functions of NADPH oxidase 5 (NOX5).",2023,10.1007/s13105-023-00955-3,https://pubmed.ncbi.nlm.nih.gov/36905456/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,40371623,Synergistic Network Pharmacology: Preclinical Validation and Clinical Safety in Acute Ischemic Stroke.,2025,10.1161/jaha.124.039098,https://pubmed.ncbi.nlm.nih.gov/40371623/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,41213585,Interactions between Tau Phosphorylation and Endoplasmic Reticulum Stress in Diabetic Nephropathy.,2026,10.4093/dmj.2024.0618,https://pubmed.ncbi.nlm.nih.gov/41213585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,37566320,Endothelial NOX5 overexpression induces changes in the cardiac gene profile: potential impact in myocardial infarction?,2023,10.1007/s13105-023-00975-z,https://pubmed.ncbi.nlm.nih.gov/37566320/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,38671844,Endothelial NOX5 Obliterates the Reno-Protective Effect of Nox4 Deletion by Promoting Renal Fibrosis via Activation of EMT and ROS-Sensitive Pathways in Diabetes.,2024,10.3390/antiox13040396,https://pubmed.ncbi.nlm.nih.gov/38671844/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,42600360,"Development of a first-in-class homolog-selective, covalent NOX4 inhibitor.",2026,10.1016/j.biopha.2026.119844,https://pubmed.ncbi.nlm.nih.gov/42600360/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,42857251,A Selective Pro-Oxidant Drives Redox Reprogramming to Induce Ferroptosis and Immune Remodeling in Glioblastoma.,2026,10.1002/smmd.70058,https://pubmed.ncbi.nlm.nih.gov/42857251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,39850563,Polydatin enhances oxaliplatin-induced cell death by activating NOX5-ROS-mediated DNA damage and ER stress in colon cancer cells.,2024,10.3389/fphar.2024.1532695,https://pubmed.ncbi.nlm.nih.gov/39850563/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,38873997,"Polydatin, a potential NOX5 agonist, synergistically enhances antitumor activity of cisplatin by stimulating oxidative stress in non‑small cell lung cancer.",2024,10.3892/ijo.2024.5665,https://pubmed.ncbi.nlm.nih.gov/38873997/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,40906132,The Effects of Dietary Supplementation with 25-Hydroxyvitamin D3 on the Antioxidant Capacity and Inflammatory Responses of &lt;i&gt;Pelteobagrus fulvidraco&lt;/i&gt;.,2025,10.3390/biology14080967,https://pubmed.ncbi.nlm.nih.gov/40906132/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,40747376,"Identification of key ferroptosis-related genes associated with the development of gastric cancer: Prognostic models, molecular mechanisms and potential treatment strategies.",2025,10.3892/ol.2025.15196,https://pubmed.ncbi.nlm.nih.gov/40747376/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,35798762,Endothelial reactive oxygen-forming NADPH oxidase 5 is a possible player in diabetic aortic aneurysm but not atherosclerosis.,2022,10.1038/s41598-022-15706-5,https://pubmed.ncbi.nlm.nih.gov/35798762/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,36940556,Regorafenib induces NOX5-mediated endoplasmic reticulum stress and potentiates the anti-tumor activity of cisplatin in non-small cell lung cancer cells.,2023,10.1016/j.neo.2023.100897,https://pubmed.ncbi.nlm.nih.gov/36940556/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,22427510,Expression and functional significance of NADPH oxidase 5 (Nox5) and its splice variants in human blood vessels.,2012,10.1152/ajpheart.00910.2011,https://pubmed.ncbi.nlm.nih.gov/22427510/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,17275676,NOX5 variants are functionally active in endothelial cells.,2007,10.1016/j.freeradbiomed.2006.10.054,https://pubmed.ncbi.nlm.nih.gov/17275676/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,16339585,Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia.,2005,10.4049/jimmunol.175.12.8424,https://pubmed.ncbi.nlm.nih.gov/16339585/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,16179589,NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts.,2005,10.1161/01.res.0000187457.24338.3d,https://pubmed.ncbi.nlm.nih.gov/16179589/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,12686516,NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells.,2003,10.1152/ajpcell.00525.2002,https://pubmed.ncbi.nlm.nih.gov/12686516/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,11483596,"A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes.",2001,10.1074/jbc.m103034200,https://pubmed.ncbi.nlm.nih.gov/11483596/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOX5,ENSG00000255346,Neither,11376945,"Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5.",2001,10.1016/s0378-1119(01)00449-8,https://pubmed.ncbi.nlm.nih.gov/11376945/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPAP1,ENSG00000185823,Neither,39440350,Diagnosis of invasive encapsulated follicular variant papillary thyroid carcinoma by protein-based machine learning.,2025,10.4132/jptm.2024.09.14,https://pubmed.ncbi.nlm.nih.gov/39440350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPAP1,ENSG00000185823,Neither,37086484,"The Mutational, Prognostic, and Therapeutic Landscape of Neuroendocrine Neoplasms.",2023,10.1093/oncolo/oyad093,https://pubmed.ncbi.nlm.nih.gov/37086484/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPAP1,ENSG00000185823,Neither,24482533,The imprinted NPAP1 gene in the Prader-Willi syndrome region belongs to a POM121-related family of retrogenes.,2014,10.1093/gbe/evu019,https://pubmed.ncbi.nlm.nih.gov/24482533/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPAP1,ENSG00000185823,Neither,36059983,Genome-wide association analysis of anti-TNF-α treatment response in Chinese patients with psoriasis.,2022,10.3389/fphar.2022.968935,https://pubmed.ncbi.nlm.nih.gov/36059983/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPAP1,ENSG00000185823,Neither,34091126,Loss of ZNF215 imprinting is associated with poor five-year survival in patients with cytogenetically abnormal-acute myeloid leukemia.,2021,10.1016/j.bcmd.2021.102577,https://pubmed.ncbi.nlm.nih.gov/34091126/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPAP1,ENSG00000185823,Neither,37407204,Mosaicism for a 15q11.2 microduplication with a normal euploid cell line at amniocentesis in a pregnancy with a favorable fetal outcome and postnatal decrease of the aneuploid cell line with the microduplication.,2023,10.1016/j.tjog.2023.05.011,https://pubmed.ncbi.nlm.nih.gov/37407204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPAP1,ENSG00000185823,Neither,22694955,The imprinted NPAP1/C15orf2 gene in the Prader-Willi syndrome region encodes a nuclear pore complex associated protein.,2012,10.1093/hmg/dds228,https://pubmed.ncbi.nlm.nih.gov/22694955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPAP1,ENSG00000185823,Neither,17337158,C15orf2 and a novel noncoding transcript from the Prader-Willi/Angelman syndrome region show monoallelic expression in fetal brain.,2007,10.1016/j.ygeno.2006.12.008,https://pubmed.ncbi.nlm.nih.gov/17337158/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPAP1,ENSG00000185823,Neither,33207545,Comprehensive Gene Mutation Profiling of Circulating Tumor DNA in Ovarian Cancer: Its Pathological and Prognostic Impact.,2020,10.3390/cancers12113382,https://pubmed.ncbi.nlm.nih.gov/33207545/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPAP1,ENSG00000185823,Neither,20020165,The C15orf2 gene in the Prader-Willi syndrome region is subject to genomic imprinting and positive selection.,2010,10.1007/s10048-009-0231-z,https://pubmed.ncbi.nlm.nih.gov/20020165/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPAP1,ENSG00000185823,Neither,28642868,An Exploration of Gene-Gene Interactions and Their Effects on Hypertension.,2017,10.1155/2017/7208318,https://pubmed.ncbi.nlm.nih.gov/28642868/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPAP1,ENSG00000185823,Neither,26198301,Expression of imprinted genes in placenta is associated with infant neurobehavioral development.,2015,10.1080/15592294.2015.1073880,https://pubmed.ncbi.nlm.nih.gov/26198301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPAP1,ENSG00000185823,Neither,24311433,Small mosaic deletion encompassing the snoRNAs and SNURF-SNRPN results in an atypical Prader-Willi syndrome phenotype.,2014,10.1002/ajmg.a.36307,https://pubmed.ncbi.nlm.nih.gov/24311433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPAP1,ENSG00000185823,Neither,32269945,Clinical characteristics and epilepsy in genomic imprinting disorders: Angelman syndrome and Prader-Willi syndrome.,2020,10.4103/tcmj.tcmj_103_19,https://pubmed.ncbi.nlm.nih.gov/32269945/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPAP1,ENSG00000185823,Neither,21233802,Copy number variations at the Prader-Willi syndrome region on chromosome 15 and associations with obesity in whites.,2011,10.1038/oby.2010.323,https://pubmed.ncbi.nlm.nih.gov/21233802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPAP1,ENSG00000185823,Neither,10783265,Identification of a testis-specific gene (C15orf2) in the Prader-Willi syndrome region on chromosome 15.,2000,10.1006/geno.2000.6158,https://pubmed.ncbi.nlm.nih.gov/10783265/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPAP1,ENSG00000185823,Neither,19066619,"A paternal deletion of MKRN3, MAGEL2 and NDN does not result in Prader-Willi syndrome.",2009,10.1038/ejhg.2008.232,https://pubmed.ncbi.nlm.nih.gov/19066619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPAP1,ENSG00000185823,Neither,18627056,Molecular and clinical characterization of two patients with Prader-Willi syndrome and atypical deletions of proximal chromosome 15q.,2008,10.1002/ajmg.a.32416,https://pubmed.ncbi.nlm.nih.gov/18627056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,42748655,Induction of ferroptotic and amyloidogenic signatures linked to Alzheimer's disease by chemically distinct air pollutants.,2026,10.1016/j.redox.2026.104390,https://pubmed.ncbi.nlm.nih.gov/42748655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,42596579,"Physiological basis of contraceptive function of a GSK3α-selective inhibitor, manifested during epididymal sperm maturation.",2026,10.1093/molehr/gaag049,https://pubmed.ncbi.nlm.nih.gov/42596579/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,41463814,NT5C1B Improves Fertility of Boar Spermatozoa by Enhancing Quality and Cryotolerance During Cryopreservation.,2025,10.3390/ani15243530,https://pubmed.ncbi.nlm.nih.gov/41463814/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,40359694,Cancer-testis antigen expression in canine melanoma and healthy tissues.,2025,10.1016/j.vetimm.2025.110946,https://pubmed.ncbi.nlm.nih.gov/40359694/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,42237266,Integrated analysis of miRNA and transcription factor gene expression profiles associated with anti-tuberculosis treatment responses.,2026,10.1186/s12879-026-13676-x,https://pubmed.ncbi.nlm.nih.gov/42237266/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,40681078,Air pollution decreases postsynaptic PSD-95 and NMDA receptor subunits in synaptosomes from mouse cerebral cortex.,2025,10.1016/j.envpol.2025.126845,https://pubmed.ncbi.nlm.nih.gov/40681078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,42741484,Integrated transcriptomics and metabolomics reveal suppression of the PPAR α/γ pathway linking purine metabolism disorder to high-protein diet-induced hyperuricemia in goslings.,2026,10.1016/j.aninu.2026.03.011,https://pubmed.ncbi.nlm.nih.gov/42741484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,38644649,Inhaled Pollutants of the Gero-Exposome and Later-Life Health.,2024,10.1093/gerona/glae107,https://pubmed.ncbi.nlm.nih.gov/38644649/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,41191906,Creating Compassionate Spaces for End-of-Life Care for Older People Experiencing Homelessness: Protocol for an Environmental Assessment of Hospice Settings.,2025,10.2196/73356,https://pubmed.ncbi.nlm.nih.gov/41191906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,38835510,Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility.,2024,10.3389/fcell.2024.1411162,https://pubmed.ncbi.nlm.nih.gov/38835510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,41324770,Whole-exome sequencing for identification of specific gene mutations in an Indian cohort of triple-negative breast cancer patients.,2025,10.1007/s12672-025-03921-1,https://pubmed.ncbi.nlm.nih.gov/41324770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,38592501,The retinal venous pressure at different levels of airway pressure measured with a new method.,2024,10.1007/s00417-024-06483-0,https://pubmed.ncbi.nlm.nih.gov/38592501/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,40729813,Transcriptome analysis of chicken fibroblast following transforming growth factor β1-mediated activation.,2025,10.1016/j.psj.2025.105576,https://pubmed.ncbi.nlm.nih.gov/40729813/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,41644158,"Doravirine versus dolutegravir-based regimen in antiretroviral treatment-naive people living with HIV-1 (ANRS0392s ELDORADO): protocol for an international, open-label, randomised, non-inferiority, phase III trial.",2026,10.1136/bmjopen-2025-110560,https://pubmed.ncbi.nlm.nih.gov/41644158/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,41688042,The effects of preventive measures against neonatal diarrhea and bovine respiratory disease (BRD) on the reproductive and milk production performance of calves in later stages.,2026,10.1055/a-2743-7073,https://pubmed.ncbi.nlm.nih.gov/41688042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,36429576,Aging in the Right Place for Older Adults Experiencing Housing Insecurity: An Environmental Assessment of Temporary Housing Program.,2022,10.3390/ijerph192214857,https://pubmed.ncbi.nlm.nih.gov/36429576/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,30854786,Cancer-testis antigens in canine histiocytic sarcoma and other malignancies.,2019,10.1111/vco.12475,https://pubmed.ncbi.nlm.nih.gov/30854786/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,32556640,The retinal venous pressure at different levels of airway pressure.,2020,10.1007/s00417-020-04796-4,https://pubmed.ncbi.nlm.nih.gov/32556640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,36794426,"PANTOTHENATE KINASE4, LOSS OF GDU2, and TRANSPOSON PROTEIN1 affect the canalization of tomato fruit metabolism.",2023,10.1093/plphys/kiad093,https://pubmed.ncbi.nlm.nih.gov/36794426/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,32004873,Toxicity of urban air pollution particulate matter in developing and adult mouse brain: Comparison of total and filter-eluted nanoparticles.,2020,10.1016/j.envint.2020.105510,https://pubmed.ncbi.nlm.nih.gov/32004873/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,42007359,Impact of air pollution on life expectancy in Asian developing countries: Does renewable energy adoption matter?,2026,10.3389/fpubh.2026.1724402,https://pubmed.ncbi.nlm.nih.gov/42007359/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,39761334,Challenges to Aging in the Right Place for Older Adults Experiencing Homelessness.,2025,10.1093/geront/gnaf002,https://pubmed.ncbi.nlm.nih.gov/39761334/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,39324302,Tech-Enabled Aging in the Right Place Will Only Succeed by Harmonizing Innovation With the Provision of Person-Centred Care.,2024,10.12927/hcpap.2024.27393,https://pubmed.ncbi.nlm.nih.gov/39324302/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,31111251,Central retinal venous pressure is higher than intraocular pressure during amateur trumpet playing.,2019,10.1007/s00417-019-04334-x,https://pubmed.ncbi.nlm.nih.gov/31111251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,22016751,Benefits of exercise with mini tennis in intellectual disabilities: effects on body image and psychopathology.,2011,10.2174/1745017901107010157,https://pubmed.ncbi.nlm.nih.gov/22016751/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,11116796,[Risperidone in the treatment of psychotic disorders associated with mental retardation].,2000,,https://pubmed.ncbi.nlm.nih.gov/11116796/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B,ENSG00000185013,Neither,11690631,Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein.,2001,10.1016/s0167-4781(01)00278-0,https://pubmed.ncbi.nlm.nih.gov/11690631/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,42748655,Induction of ferroptotic and amyloidogenic signatures linked to Alzheimer's disease by chemically distinct air pollutants.,2026,10.1016/j.redox.2026.104390,https://pubmed.ncbi.nlm.nih.gov/42748655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,40681078,Air pollution decreases postsynaptic PSD-95 and NMDA receptor subunits in synaptosomes from mouse cerebral cortex.,2025,10.1016/j.envpol.2025.126845,https://pubmed.ncbi.nlm.nih.gov/40681078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,38644649,Inhaled Pollutants of the Gero-Exposome and Later-Life Health.,2024,10.1093/gerona/glae107,https://pubmed.ncbi.nlm.nih.gov/38644649/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,41191906,Creating Compassionate Spaces for End-of-Life Care for Older People Experiencing Homelessness: Protocol for an Environmental Assessment of Hospice Settings.,2025,10.2196/73356,https://pubmed.ncbi.nlm.nih.gov/41191906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,38592501,The retinal venous pressure at different levels of airway pressure measured with a new method.,2024,10.1007/s00417-024-06483-0,https://pubmed.ncbi.nlm.nih.gov/38592501/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,41644158,"Doravirine versus dolutegravir-based regimen in antiretroviral treatment-naive people living with HIV-1 (ANRS0392s ELDORADO): protocol for an international, open-label, randomised, non-inferiority, phase III trial.",2026,10.1136/bmjopen-2025-110560,https://pubmed.ncbi.nlm.nih.gov/41644158/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,41688042,The effects of preventive measures against neonatal diarrhea and bovine respiratory disease (BRD) on the reproductive and milk production performance of calves in later stages.,2026,10.1055/a-2743-7073,https://pubmed.ncbi.nlm.nih.gov/41688042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,36429576,Aging in the Right Place for Older Adults Experiencing Housing Insecurity: An Environmental Assessment of Temporary Housing Program.,2022,10.3390/ijerph192214857,https://pubmed.ncbi.nlm.nih.gov/36429576/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,32556640,The retinal venous pressure at different levels of airway pressure.,2020,10.1007/s00417-020-04796-4,https://pubmed.ncbi.nlm.nih.gov/32556640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,36794426,"PANTOTHENATE KINASE4, LOSS OF GDU2, and TRANSPOSON PROTEIN1 affect the canalization of tomato fruit metabolism.",2023,10.1093/plphys/kiad093,https://pubmed.ncbi.nlm.nih.gov/36794426/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,32004873,Toxicity of urban air pollution particulate matter in developing and adult mouse brain: Comparison of total and filter-eluted nanoparticles.,2020,10.1016/j.envint.2020.105510,https://pubmed.ncbi.nlm.nih.gov/32004873/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,28898192,"Intracranial Teratoma: Imaging, Intraoperative, and Pathologic Features: AIRP Best Cases in Radiologic-Pathologic Correlation.",2017,10.1148/rg.2017160202,https://pubmed.ncbi.nlm.nih.gov/28898192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,28671353,Retinal venous pressure is higher than the airway pressure and the intraocular pressure during the Valsalva manoeuvre.,2018,10.1111/aos.13485,https://pubmed.ncbi.nlm.nih.gov/28671353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,23479715,AIRP best cases in radiologic-pathologic correlation: alveolar soft-part sarcoma.,2013,10.1148/rg.332115173,https://pubmed.ncbi.nlm.nih.gov/23479715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,22411946,AIRP best cases in radiologic-pathologic correlation: human coenurosis (Taenia Larva).,2012,10.1148/rg.322105230,https://pubmed.ncbi.nlm.nih.gov/22411946/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,31111251,Central retinal venous pressure is higher than intraocular pressure during amateur trumpet playing.,2019,10.1007/s00417-019-04334-x,https://pubmed.ncbi.nlm.nih.gov/31111251/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,22977019,AIRP best cases in radiologic-pathologic correlation: cerebral fat embolism syndrome in sickle cell β-thalassemia.,2012,10.1148/rg.325115055,https://pubmed.ncbi.nlm.nih.gov/22977019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,21391037,The role of orthophosphate and dissolved oxygen in the performance of arsenic-iron removal plants in Bangladesh.,2011,10.1080/10934529.2011.549409,https://pubmed.ncbi.nlm.nih.gov/21391037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,22016751,Benefits of exercise with mini tennis in intellectual disabilities: effects on body image and psychopathology.,2011,10.2174/1745017901107010157,https://pubmed.ncbi.nlm.nih.gov/22016751/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,42007359,Impact of air pollution on life expectancy in Asian developing countries: Does renewable energy adoption matter?,2026,10.3389/fpubh.2026.1724402,https://pubmed.ncbi.nlm.nih.gov/42007359/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,39761334,Challenges to Aging in the Right Place for Older Adults Experiencing Homelessness.,2025,10.1093/geront/gnaf002,https://pubmed.ncbi.nlm.nih.gov/39761334/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,39324302,Tech-Enabled Aging in the Right Place Will Only Succeed by Harmonizing Innovation With the Provision of Person-Centred Care.,2024,10.12927/hcpap.2024.27393,https://pubmed.ncbi.nlm.nih.gov/39324302/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,11116796,[Risperidone in the treatment of psychotic disorders associated with mental retardation].,2000,,https://pubmed.ncbi.nlm.nih.gov/11116796/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5C1B-RDH14,ENSG00000250741,Neither,11690631,Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein.,2001,10.1016/s0167-4781(01)00278-0,https://pubmed.ncbi.nlm.nih.gov/11690631/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OCM2,ENSG00000135175,Neither,37239828,Differentially Expressed Genes Induced by Erythropoietin Receptor Overexpression in Rat Mammary Adenocarcinoma RAMA 37-28 Cells.,2023,10.3390/ijms24108482,https://pubmed.ncbi.nlm.nih.gov/37239828/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OCM2,ENSG00000135175,Neither,32996353,Whole exome sequencing identifies rare coding variants in novel human-mouse ortholog genes in African individuals diagnosed with non-syndromic hearing impairment.,2021,10.1177/1535370220960388,https://pubmed.ncbi.nlm.nih.gov/32996353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OCM2,ENSG00000135175,Neither,29411893,Genome-wide association study for reproductive traits in a Large White pig population.,2018,10.1111/age.12638,https://pubmed.ncbi.nlm.nih.gov/29411893/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OCM2,ENSG00000135175,Neither,39168286,Deferasirox nanosuspension loaded dissolving microneedles for ocular drug delivery.,2024,10.1016/j.ijpharm.2024.124614,https://pubmed.ncbi.nlm.nih.gov/39168286/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR10A4,ENSG00000170782,Neither,42303203,Activation of the olfactory receptors OR7D2 and OR10A4 by natural odorants modulates inflammatory responses in human keratinocytes.,2026,10.1016/j.cbi.2026.112214,https://pubmed.ncbi.nlm.nih.gov/42303203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR10A4,ENSG00000170782,Neither,32640699,Novel Nasal Epithelial Cell Markers of Parkinson's Disease Identified Using Cells Treated with α-Synuclein Preformed Fibrils.,2020,10.3390/jcm9072128,https://pubmed.ncbi.nlm.nih.gov/32640699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR10A4,ENSG00000170782,Neither,26632885,An epigenomic signature of postprandial hyperglycemia in peripheral blood leukocytes.,2016,10.1038/jhg.2015.140,https://pubmed.ncbi.nlm.nih.gov/26632885/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR10A4,ENSG00000170782,Neither,33633776,Gene Banks as Reservoirs to Detect Recent Selection: The Example of the Asturiana de los Valles Bovine Breed.,2021,10.3389/fgene.2021.575405,https://pubmed.ncbi.nlm.nih.gov/33633776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR10A7,ENSG00000179919,Neither,38136858,Genome-Wide Association Analysis Identifies the PMEL Gene Affecting Coat Color and Birth Weight in Simmental × Holstein.,2023,10.3390/ani13243821,https://pubmed.ncbi.nlm.nih.gov/38136858/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR10D3,ENSG00000197309,Neither,42192833,Genomic Profiling of Adults with Pharmacoresistant Genetic Generalized Epilepsy.,2026,10.3390/brainsci16050521,https://pubmed.ncbi.nlm.nih.gov/42192833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR10D3,ENSG00000197309,Neither,40837069,Genome-Wide Association Study and Rare Variant Association Studies of Strabismus in the &lt;i&gt;All of Us&lt;/i&gt; Research Program.,2025,10.1016/j.xops.2025.100873,https://pubmed.ncbi.nlm.nih.gov/40837069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR10H5,ENSG00000172519,Neither,42231301,Prospective germline exome and machine learning-based risk score identify predictive and prognostic biomarkers of immunotherapy outcomes in advanced non-small cell lung cancer.,2026,10.1186/s12967-026-08374-w,https://pubmed.ncbi.nlm.nih.gov/42231301/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR10H5,ENSG00000172519,Neither,27609023,A 19-Gene expression signature as a predictor of survival in colorectal cancer.,2016,10.1186/s12920-016-0218-1,https://pubmed.ncbi.nlm.nih.gov/27609023/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR10J1,ENSG00000196184,Neither,31122248,Exome-wide search and functional annotation of genes associated in patients with severe tick-borne encephalitis in a Russian population.,2019,10.1186/s12920-019-0503-x,https://pubmed.ncbi.nlm.nih.gov/31122248/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR11A1,ENSG00000204694,Neither,40995806,"Olfactory detection of ursodeoxycholic acid (UDCA) in large yellow croaker (Larimichthys crocea): responses, pathways and receptor functions.",2025,10.1242/jeb.250571,https://pubmed.ncbi.nlm.nih.gov/40995806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR11A1,ENSG00000204694,Neither,38955350,"Geosmin, a Food- and Water-Deteriorating Sesquiterpenoid and Ambivalent Semiochemical, Activates Evolutionary Conserved Receptor OR11A1.",2024,10.1021/acs.jafc.4c01515,https://pubmed.ncbi.nlm.nih.gov/38955350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR11A1,ENSG00000204694,Neither,17069989,Microarray analysis of radiation response genes in primary human fibroblasts.,2006,10.1016/j.ijrobp.2006.08.004,https://pubmed.ncbi.nlm.nih.gov/17069989/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR11G2,ENSG00000196832,Neither,39952115,"Odorants have the potential to enhance the heterologous expression of human olfactory receptors: Evidence from ethyl 3-phenylglycidate and its effects on OR1A1, OR11G2, and OR2W1.",2025,10.1016/j.bbrc.2025.151459,https://pubmed.ncbi.nlm.nih.gov/39952115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR11H4,ENSG00000176198,Neither,36222933,Differential Expression in the Tumor Microenvironment of mRNAs Closely Associated with Colorectal Cancer Metastasis.,2023,10.1245/s10434-022-12574-1,https://pubmed.ncbi.nlm.nih.gov/36222933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR11H4,ENSG00000176198,Neither,33081083,A Rose Extract Protects the Skin against Stress Mediators: A Potential Role of Olfactory Receptors.,2020,10.3390/molecules25204743,https://pubmed.ncbi.nlm.nih.gov/33081083/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR11H6,ENSG00000176219,Neither,36978520,Comparative Analysis of Olfactory Receptor Repertoires Sheds Light on the Diet Adaptation of the Bamboo-Eating Giant Panda Based on the Chromosome-Level Genome.,2023,10.3390/ani13060979,https://pubmed.ncbi.nlm.nih.gov/36978520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR13G1,ENSG00000197437,Neither,42287815,Patchouli oil and its main component patchouli alcohol inhibit colorectal cancer by activating ectopic olfactory receptor.,2026,10.1016/j.phymed.2026.158408,https://pubmed.ncbi.nlm.nih.gov/42287815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR13G1,ENSG00000197437,Neither,18599554,Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia.,2008,10.1093/eurheartj/ehn303,https://pubmed.ncbi.nlm.nih.gov/18599554/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR13G1,ENSG00000197437,Neither,16175505,Identification of four gene variants associated with myocardial infarction.,2005,10.1086/491674,https://pubmed.ncbi.nlm.nih.gov/16175505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR14A16,ENSG00000196772,Neither,39856550,Whole-genome resequencing landscape of adaptive evolution in Relict gull (Larus relictus).,2025,10.1186/s12864-025-11257-x,https://pubmed.ncbi.nlm.nih.gov/39856550/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR14A2,ENSG00000241128,Neither,38474024,Transcriptomic Signatures of Neuronally Derived Extracellular Vesicles Reveal the Presence of Olfactory Receptors in Clinical Samples from Traumatic Brain Injury Patients.,2024,10.3390/ijms25052777,https://pubmed.ncbi.nlm.nih.gov/38474024/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR14A2,ENSG00000241128,Neither,39633301,Genomic signatures of sensory adaptation and evolution in pangolins.,2024,10.1186/s12864-024-11063-x,https://pubmed.ncbi.nlm.nih.gov/39633301/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR14J1,ENSG00000204695,Neither,40719081,Gene-Smoking Interaction in Insulin Sensitivity and β-Cell Function Among Normal Glucose Tolerance Individuals.,2025,10.1111/1753-0407.70131,https://pubmed.ncbi.nlm.nih.gov/40719081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR14J1,ENSG00000204695,Neither,39856550,Whole-genome resequencing landscape of adaptive evolution in Relict gull (Larus relictus).,2025,10.1186/s12864-025-11257-x,https://pubmed.ncbi.nlm.nih.gov/39856550/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1C1,ENSG00000221888,Neither,40538218,Orphan G Protein-Coupled Receptors: A Novel Research Frontier in Autism and Associated Disorders.,2025,10.1002/ardp.70018,https://pubmed.ncbi.nlm.nih.gov/40538218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1C1,ENSG00000221888,Neither,37574491,Towards the convergent therapeutic potential of G protein-coupled receptors in autism spectrum disorders.,2025,10.1111/bph.16216,https://pubmed.ncbi.nlm.nih.gov/37574491/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1E1,ENSG00000180016,Neither,35205299,Genomic Diversity Profiling and Breed-Specific Evolutionary Signatures of Selection in Arunachali Yak.,2022,10.3390/genes13020254,https://pubmed.ncbi.nlm.nih.gov/35205299/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1E1,ENSG00000180016,Neither,31889940,The plasma peptides of breast versus ovarian cancer.,2019,10.1186/s12014-019-9262-0,https://pubmed.ncbi.nlm.nih.gov/31889940/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1E1,ENSG00000180016,Neither,23656994,Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain.,2013,10.1097/nen.0b013e318294fd76,https://pubmed.ncbi.nlm.nih.gov/23656994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1G1,ENSG00000183024,Neither,39538061,Functional characterization of OR51B5 and OR1G1 in human lung epithelial cells as potential drug targets for non-type 2 lung diseases.,2024,10.1007/s10565-024-09935-9,https://pubmed.ncbi.nlm.nih.gov/39538061/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1G1,ENSG00000183024,Neither,37348876,Large-scale rare variant burden testing in Parkinson's disease.,2023,10.1093/brain/awad214,https://pubmed.ncbi.nlm.nih.gov/37348876/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1G1,ENSG00000183024,Neither,38965271,Impaired metal perception and regulation of associated human foliate papillae tongue transcriptome in long-COVID-19.,2024,10.1038/s41598-024-66079-w,https://pubmed.ncbi.nlm.nih.gov/38965271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1G1,ENSG00000183024,Neither,40428486,"The New Aristocrat of Wuyi Rock Tea: Chemical Basis of the Unique Aroma Quality of ""Laocong Shuixian"".",2025,10.3390/foods14101706,https://pubmed.ncbi.nlm.nih.gov/40428486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1G1,ENSG00000183024,Neither,38877790,Effects of genetics on odor perception: Can a quick smell test effectively screen everyone?,2024,10.1093/chemse/bjae025,https://pubmed.ncbi.nlm.nih.gov/38877790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1G1,ENSG00000183024,Neither,32787931,Thymol modulates the endocannabinoid system and gut chemosensing of weaning pigs.,2020,10.1186/s12917-020-02516-y,https://pubmed.ncbi.nlm.nih.gov/32787931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1G1,ENSG00000183024,Neither,22926438,How broadly tuned olfactory receptors equally recognize their agonists. Human OR1G1 as a test case.,2012,10.1007/s00018-012-1116-0,https://pubmed.ncbi.nlm.nih.gov/22926438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1G1,ENSG00000183024,Neither,21372164,Effects of luminal thymol on epithelial transport in human and rat colon.,2011,10.1152/ajpgi.00503.2010,https://pubmed.ncbi.nlm.nih.gov/21372164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1G1,ENSG00000183024,Neither,18556422,"Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants.",2008,10.1152/ajpgi.00056.2008,https://pubmed.ncbi.nlm.nih.gov/18556422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1G1,ENSG00000183024,Neither,41868604,"An integrated approach to smoky food flavor: Decoding key odorants, sensory contributions, and olfactory recognition mechanisms.",2026,10.1016/j.crfs.2026.101377,https://pubmed.ncbi.nlm.nih.gov/41868604/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1J4,ENSG00000239590,Neither,39986510,"High-resolution LC-MS/MS combined with TMT quantitative proteomic analysis reveals regulatory mechanism of sperm capacitation by heparin, Ca&lt;sup&gt;2+&lt;/sup&gt; and BSA.",2025,10.1016/j.ijbiomac.2025.141349,https://pubmed.ncbi.nlm.nih.gov/39986510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1L3,ENSG00000171481,Neither,38235001,CCL7 and olfactory transduction pathway activation play an important role in the formation of CaOx and CaP kidney stones.,2023,10.3389/fgene.2023.1267545,https://pubmed.ncbi.nlm.nih.gov/38235001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1L3,ENSG00000171481,Neither,23205112,Whole-exome sequencing identifies mutated PCK2 and HUWE1 associated with carcinoma cell proliferation in a hepatocellular carcinoma patient.,2012,10.3892/ol.2012.825,https://pubmed.ncbi.nlm.nih.gov/23205112/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1N1,ENSG00000171505,Neither,41317264,"RELM-β Augmented Hypoxia-Induced Pulmonary Hypertension Through Interacting with GIPC1, OR1N1 and CLIC4.",2026,10.1007/s10557-025-07816-9,https://pubmed.ncbi.nlm.nih.gov/41317264/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2AK2,ENSG00000187080,Neither,42471926,Formation of characteristic aroma compounds in walnut kernels during thermal processing and their potential recognition by human olfactory receptors.,2026,10.1016/j.fochx.2026.104142,https://pubmed.ncbi.nlm.nih.gov/42471926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2AK2,ENSG00000187080,Neither,35117914,TNFRSF12A and a new prognostic model identified from methylation combined with expression profiles to predict overall survival in hepatocellular carcinoma.,2020,10.21037/tcr-20-1342,https://pubmed.ncbi.nlm.nih.gov/35117914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2AK2,ENSG00000187080,Neither,29868124,Genetics of Obesity Traits: A Bivariate Genome-Wide Association Analysis.,2018,10.3389/fgene.2018.00179,https://pubmed.ncbi.nlm.nih.gov/29868124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2C3,ENSG00000196242,Neither,40272067,Genome-wide DNA methylation profiles in the raphe nuclei of patients with autism spectrum disorder.,2025,10.1111/pcn.13830,https://pubmed.ncbi.nlm.nih.gov/40272067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2C3,ENSG00000196242,Neither,39892222,Single-cell RNA sequencing integrated with bulk RNA sequencing analysis of clock circadian regulator with prognostic and immune microenvironment in thyroid cancer.,2025,10.1016/j.tranon.2025.102299,https://pubmed.ncbi.nlm.nih.gov/39892222/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2C3,ENSG00000196242,Neither,28492065,Revisiting olfactory receptors as putative drivers of cancer.,2017,10.12688/wellcomeopenres.10646.1,https://pubmed.ncbi.nlm.nih.gov/28492065/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2C3,ENSG00000196242,Neither,31640099,"Genome-Wide Methylation of Mild Cognitive Impairment in Mexican Americans Highlights Genes Involved in Synaptic Transport, Alzheimer's Disease-Precursor Phenotypes, and Metabolic Morbidities.",2019,10.3233/jad-190634,https://pubmed.ncbi.nlm.nih.gov/31640099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2D2,ENSG00000166368,Neither,39852128,Identification of Olfactory Receptors Responding to Androstenone and the Key Structure Determinant in Domestic Pig.,2024,10.3390/cimb47010013,https://pubmed.ncbi.nlm.nih.gov/39852128/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2D2,ENSG00000166368,Neither,33633776,Gene Banks as Reservoirs to Detect Recent Selection: The Example of the Asturiana de los Valles Bovine Breed.,2021,10.3389/fgene.2021.575405,https://pubmed.ncbi.nlm.nih.gov/33633776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2F1,ENSG00000213215,Neither,40747002,Population Genomic Analysis Provides Insights Into the Evolution and Conservation of Two Critically Endangered Musk Deer Species.,2025,10.1111/eva.70134,https://pubmed.ncbi.nlm.nih.gov/40747002/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2J2,ENSG00000204700,Neither,38965271,Impaired metal perception and regulation of associated human foliate papillae tongue transcriptome in long-COVID-19.,2024,10.1038/s41598-024-66079-w,https://pubmed.ncbi.nlm.nih.gov/38965271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2J2,ENSG00000204700,Neither,40361640,"Chemical, Sensory Variations in Black Teas from Six Tea Cultivars in Jingshan, China.",2025,10.3390/foods14091558,https://pubmed.ncbi.nlm.nih.gov/40361640/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2J2,ENSG00000204700,Neither,35698620,Effective Treatment of Low-Grade Myofibroblastic Sarcoma with Apatinib: A Case Report and Literature Review.,2022,10.2147/pgpm.s359492,https://pubmed.ncbi.nlm.nih.gov/35698620/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2J3,ENSG00000204701,Neither,38583306,Olfactory receptors impact pathophysiological processes of lung diseases in bronchial epithelial cells.,2024,10.1016/j.ejcb.2024.151408,https://pubmed.ncbi.nlm.nih.gov/38583306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2J3,ENSG00000204701,Neither,35113854,From musk to body odor: Decoding olfaction through genetic variation.,2022,10.1371/journal.pgen.1009564,https://pubmed.ncbi.nlm.nih.gov/35113854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2J3,ENSG00000204701,Neither,27939274,Helional-induced activation of human olfactory receptor 2J3 promotes apoptosis and inhibits proliferation in a non-small-cell lung cancer cell line.,2017,10.1016/j.ejcb.2016.11.004,https://pubmed.ncbi.nlm.nih.gov/27939274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2J3,ENSG00000204701,Neither,31046287,In Silico Peptide Repertoire of Human Olfactory Receptor Proteomes on High-Stringency Mass Spectrometry.,2019,10.1021/acs.jproteome.8b00494,https://pubmed.ncbi.nlm.nih.gov/31046287/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2J3,ENSG00000204701,Neither,22714804,"Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the ""grassy"" smelling odor, cis-3-hexen-1-ol.",2012,10.1093/chemse/bjs049,https://pubmed.ncbi.nlm.nih.gov/22714804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2J3,ENSG00000204701,Neither,23656994,Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain.,2013,10.1097/nen.0b013e318294fd76,https://pubmed.ncbi.nlm.nih.gov/23656994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2J3,ENSG00000204701,Neither,27553203,Helional induces Ca2+ decrease and serotonin secretion of QGP-1 cells via a PKG-mediated pathway.,2016,10.1530/jme-16-0063,https://pubmed.ncbi.nlm.nih.gov/27553203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2K2,ENSG00000171133,Neither,38540444,Olfactory Receptor OR2K2 Expression in Human Choroid Plexus as a Potential Marker in Early Sporadic Alzheimer's Disease.,2024,10.3390/genes15030385,https://pubmed.ncbi.nlm.nih.gov/38540444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2K2,ENSG00000171133,Neither,41443105,Thymosin β4-derived peptides alleviate neuroinflammation and neurite atrophy in both in vitro models and in vivo 5 × FAD mice: A potential therapy for memory improvement in Alzheimer's disease.,2026,10.1016/j.intimp.2025.116097,https://pubmed.ncbi.nlm.nih.gov/41443105/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2K2,ENSG00000171133,Neither,24581549,"Genetic modifiers and subtypes in schizophrenia: investigations of age at onset, severity, sex and family history.",2014,10.1016/j.schres.2014.01.030,https://pubmed.ncbi.nlm.nih.gov/24581549/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2W1,ENSG00000204704,Neither,41832187,Elucidating odorant synergy in red wine: through olfactory receptor-based profiling.,2026,10.1038/s41538-026-00793-9,https://pubmed.ncbi.nlm.nih.gov/41832187/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2W1,ENSG00000204704,Neither,42887696,Vitiligo-associated variants and genes beyond immune-related loci: A genome-wide association and Mendelian randomization meta-analysis.,2026,10.1016/j.jid.2026.09.859,https://pubmed.ncbi.nlm.nih.gov/42887696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2W1,ENSG00000204704,Neither,41227576,Sensory-Chemical Co-Dynamics in &lt;i&gt;Kadsura coccinea&lt;/i&gt;: ROAV-Driven Prioritization of Cultivar-Specific Odorants and Mechanistic Validation via Molecular Docking.,2025,10.3390/foods14213603,https://pubmed.ncbi.nlm.nih.gov/41227576/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2W1,ENSG00000204704,Neither,42047253,Urine-Based Noninvasive Detection of Prostate Cancer Using Human Olfactory Receptor-Embedded Nanodiscs.,2026,10.1021/acssensors.6c00794,https://pubmed.ncbi.nlm.nih.gov/42047253/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2W1,ENSG00000204704,Neither,39952115,"Odorants have the potential to enhance the heterologous expression of human olfactory receptors: Evidence from ethyl 3-phenylglycidate and its effects on OR1A1, OR11G2, and OR2W1.",2025,10.1016/j.bbrc.2025.151459,https://pubmed.ncbi.nlm.nih.gov/39952115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2W1,ENSG00000204704,Neither,40920623,Causal associations between psoriasis and atopic dermatitis: A bidirectional Mendelian randomization study.,2025,10.1371/journal.pone.0322602,https://pubmed.ncbi.nlm.nih.gov/40920623/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2W1,ENSG00000204704,Neither,41154105,Compounds of Essential Oils from Different Parts of &lt;i&gt;Cinnamomum cassia&lt;/i&gt; and the Perception Mechanism of Their Characteristic Flavors.,2025,10.3390/foods14203570,https://pubmed.ncbi.nlm.nih.gov/41154105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2W1,ENSG00000204704,Neither,34857413,The key food odorant receptive range of broadly tuned receptor OR2W1.,2022,10.1016/j.foodchem.2021.131680,https://pubmed.ncbi.nlm.nih.gov/34857413/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2W1,ENSG00000204704,Neither,33840173,Computational evaluation of interactions between olfactory receptor OR2W1 and its ligands.,2021,10.5808/gi.21026,https://pubmed.ncbi.nlm.nih.gov/33840173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2W1,ENSG00000204704,Neither,34768977,Machine Learning Assisted Approach for Finding Novel High Activity Agonists of Human Ectopic Olfactory Receptors.,2021,10.3390/ijms222111546,https://pubmed.ncbi.nlm.nih.gov/34768977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2W1,ENSG00000204704,Neither,31435697,Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3.,2020,10.1007/s00018-019-03279-y,https://pubmed.ncbi.nlm.nih.gov/31435697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2W1,ENSG00000204704,Neither,29648835,Agonists of G-Protein-Coupled Odorant Receptors Are Predicted from Chemical Features.,2018,10.1021/acs.jpclett.8b00633,https://pubmed.ncbi.nlm.nih.gov/29648835/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2W1,ENSG00000204704,Neither,24695519,Identification of odorant-receptor interactions by global mapping of the human odorome.,2014,10.1371/journal.pone.0093037,https://pubmed.ncbi.nlm.nih.gov/24695519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2W1,ENSG00000204704,Neither,40964851,Molecular recognition and protein interaction mechanisms of volatile organic compounds from Cornus officinalis leaves: a network pharmacology and multiscale validation study centered on β-ionone.,2025,10.1002/jsfa.70132,https://pubmed.ncbi.nlm.nih.gov/40964851/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4A16,ENSG00000181961,Neither,40945769,Whole exome sequencing analysis of suicidal thoughts and behaviors in a veteran cohort implicates inflammatory pathways and genes previously associated with psychiatric and neurodegenerative diseases.,2026,10.1016/j.jad.2025.120301,https://pubmed.ncbi.nlm.nih.gov/40945769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4A16,ENSG00000181961,Neither,38375886,Transcriptomic evaluation of skin tape-strips in children with allergic asthma uncovers epidermal barrier dysfunction and asthma-associated biomarkers abnormalities.,2024,10.1111/all.16060,https://pubmed.ncbi.nlm.nih.gov/38375886/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4D1,ENSG00000141194,Neither,35323665,Can Exercise Training Alter Human Skeletal Muscle DNA Methylation?,2022,10.3390/metabo12030222,https://pubmed.ncbi.nlm.nih.gov/35323665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4D6,ENSG00000166884,Neither,32345670,The Clinical Relevance of Frequent Germline Genetic Variants Detected by Targeted Sequencing in Patients With Rectal Adenocarcinoma (READ).,2020,10.21873/cgp.20189,https://pubmed.ncbi.nlm.nih.gov/32345670/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4D6,ENSG00000166884,Neither,35113854,From musk to body odor: Decoding olfaction through genetic variation.,2022,10.1371/journal.pgen.1009564,https://pubmed.ncbi.nlm.nih.gov/35113854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4D6,ENSG00000166884,Neither,26378035,Using Whole-Exome Sequencing to Identify Genetic Markers for Carboplatin and Gemcitabine-Induced Toxicities.,2016,10.1158/1078-0432.ccr-15-0964,https://pubmed.ncbi.nlm.nih.gov/26378035/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4E2,ENSG00000221977,Neither,38069004,Exploring the Potential of Olfactory Receptor Circulating RNA Measurement for Preeclampsia Prediction and Its Linkage to Mild Gestational Hypothyroidism.,2023,10.3390/ijms242316681,https://pubmed.ncbi.nlm.nih.gov/38069004/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4F3,ENSG00000230178,Neither,26769853,Gene copy number variations in the leukocyte genome of hepatocellular carcinoma patients with integrated hepatitis B virus DNA.,2016,10.18632/oncotarget.6895,https://pubmed.ncbi.nlm.nih.gov/26769853/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4F3,ENSG00000230178,Neither,31417659,HBV Integration-mediated Cell Apoptosis in HepG2.2.15.,2019,10.7150/jca.30493,https://pubmed.ncbi.nlm.nih.gov/31417659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4M1,ENSG00000176299,Neither,39821628,Citronellal Alleviates Insulin Resistance in High-Fat Diet/Streptozocin Model: Role of Asprosin/Olfactory Receptor Axis.,2025,10.1002/mnfr.202400654,https://pubmed.ncbi.nlm.nih.gov/39821628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4M1,ENSG00000176299,Neither,40871563,Effects of Asprosin and Role of TLR4 as a Biomarker in Endometrial Cancer.,2025,10.3390/molecules30163410,https://pubmed.ncbi.nlm.nih.gov/40871563/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4M1,ENSG00000176299,Neither,34386072,"A pancancer overview of FBN1, asprosin and its cognate receptor OR4M1 with detailed expression profiling in ovarian cancer.",2021,10.3892/ol.2021.12911,https://pubmed.ncbi.nlm.nih.gov/34386072/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4M1,ENSG00000176299,Neither,40806011,Hepatic Olfr734 Deficiency Worsens Hepatic Glucose Metabolism and Induces MASLD in Mice.,2025,10.3390/nu17152426,https://pubmed.ncbi.nlm.nih.gov/40806011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4M1,ENSG00000176299,Neither,37167929,Developmental and hormonal regulation of FBN1 and OR4M1 mRNA in bovine granulosa cells.,2023,10.1016/j.domaniend.2023.106791,https://pubmed.ncbi.nlm.nih.gov/37167929/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4M1,ENSG00000176299,Neither,40358915,Photobiomodulation Promotes Early Recovery of Olfactory Function and Modulates Neuroprotective Gene Expression in a Mouse Model of Ischemic Stroke.,2025,10.1007/s12975-025-01343-3,https://pubmed.ncbi.nlm.nih.gov/40358915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4M1,ENSG00000176299,Neither,36233808,Differential Regulation of Genes by the Glucogenic Hormone Asprosin in Ovarian Cancer.,2022,10.3390/jcm11195942,https://pubmed.ncbi.nlm.nih.gov/36233808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4M1,ENSG00000176299,Neither,35707591,"Asprosin, a C-Terminal Cleavage Product of Fibrillin 1 Encoded by the FBN1 Gene, in Health and Disease.",2022,10.1159/000520333,https://pubmed.ncbi.nlm.nih.gov/35707591/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4M1,ENSG00000176299,Neither,32198197,Energy Regulation Mechanism and Therapeutic Potential of Asprosin.,2020,10.2337/dbi19-0009,https://pubmed.ncbi.nlm.nih.gov/32198197/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4M1,ENSG00000176299,Neither,34781067,A potential role of fibrillin-1 (FBN1) mRNA and asprosin in follicular development in water buffalo.,2022,10.1016/j.theriogenology.2021.11.004,https://pubmed.ncbi.nlm.nih.gov/34781067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4M1,ENSG00000176299,Neither,33112803,Discovery of a possible role of asprosin in ovarian follicular function.,2021,10.1530/jme-20-0218,https://pubmed.ncbi.nlm.nih.gov/33112803/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4M1,ENSG00000176299,Neither,26910498,In Silico Modeling of Novel Drug Ligands for Treatment of Concussion Associated Tauopathy.,2016,10.1002/jcb.25521,https://pubmed.ncbi.nlm.nih.gov/26910498/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4M1,ENSG00000176299,Neither,36978520,Comparative Analysis of Olfactory Receptor Repertoires Sheds Light on the Diet Adaptation of the Bamboo-Eating Giant Panda Based on the Chromosome-Level Genome.,2023,10.3390/ani13060979,https://pubmed.ncbi.nlm.nih.gov/36978520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4M1,ENSG00000176299,Neither,23241557,Decreased level of olfactory receptors in blood cells following traumatic brain injury and potential association with tauopathy.,2013,10.3233/jad-121894,https://pubmed.ncbi.nlm.nih.gov/23241557/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4M1,ENSG00000176299,Neither,31230984,OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin.,2019,10.1016/j.cmet.2019.05.022,https://pubmed.ncbi.nlm.nih.gov/31230984/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4M2,ENSG00000274102,Neither,36978520,Comparative Analysis of Olfactory Receptor Repertoires Sheds Light on the Diet Adaptation of the Bamboo-Eating Giant Panda Based on the Chromosome-Level Genome.,2023,10.3390/ani13060979,https://pubmed.ncbi.nlm.nih.gov/36978520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4M2,ENSG00000274102,Neither,21154326,[Copy number variation analysis of a Chinese Han family with autism spectrum disorder].,2010,10.3760/cma.j.issn.1003-9406.2010.06.011,https://pubmed.ncbi.nlm.nih.gov/21154326/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4M2,ENSG00000274102,Neither,25924657,Concurrent exome-targeted next-generation sequencing and single nucleotide polymorphism array to identify the causative genetic aberrations of isolated Mayer-Rokitansky-Küster-Hauser syndrome.,2015,10.1093/humrep/dev095,https://pubmed.ncbi.nlm.nih.gov/25924657/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4N2,ENSG00000176294,Neither,36134028,A p53 transcriptional signature in primary and metastatic cancers derived using machine learning.,2022,10.3389/fgene.2022.987238,https://pubmed.ncbi.nlm.nih.gov/36134028/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4N2,ENSG00000176294,Neither,30786925,Next-generation sequencing-based genomic profiling analysis reveals novel mutations for clinical diagnosis in Chinese primary epithelial ovarian cancer patients.,2019,10.1186/s13048-019-0494-4,https://pubmed.ncbi.nlm.nih.gov/30786925/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4N2,ENSG00000176294,Neither,32034058,Integrated characterisation of cancer genes identifies key molecular biomarkers in stomach adenocarcinoma.,2020,10.1136/jclinpath-2019-206400,https://pubmed.ncbi.nlm.nih.gov/32034058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4N4,ENSG00000183706,Neither,40694278,Microarray and Single-Cell RNA Sequencing Reveals G-Protein Gene Expression Signatures of Spermatogonia Stem Cell.,2025,10.1007/s12015-025-10942-4,https://pubmed.ncbi.nlm.nih.gov/40694278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4N4,ENSG00000183706,Neither,23405139,Expression profile of ectopic olfactory receptors determined by deep sequencing.,2013,10.1371/journal.pone.0055368,https://pubmed.ncbi.nlm.nih.gov/23405139/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4N4,ENSG00000183706,Neither,27006382,Gene expression profiling in undifferentiated thyroid carcinoma induced by high-dose radiation.,2016,10.1093/jrr/rrw002,https://pubmed.ncbi.nlm.nih.gov/27006382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4N4,ENSG00000183706,Neither,18266248,Array comparative genomic hybridization (aCGH) analysis in Prader-Willi syndrome.,2008,10.1002/ajmg.a.32249,https://pubmed.ncbi.nlm.nih.gov/18266248/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4Q3,ENSG00000182652,Neither,33324446,Multi-Omics Analysis Reveals Novel Subtypes and Driver Genes in Glioblastoma.,2020,10.3389/fgene.2020.565341,https://pubmed.ncbi.nlm.nih.gov/33324446/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR4Q3,ENSG00000182652,Neither,33259306,An Enhanced Random Forests Approach to Predict Heart Failure From Small Imbalanced Gene Expression Data.,2021,10.1109/tcbb.2020.3041527,https://pubmed.ncbi.nlm.nih.gov/33259306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR51A7,ENSG00000176895,Neither,37533582,Transcriptome Profiling of Anhidrotic Eccrine Sweat Glands Reveals that Olfactory Receptors on Eccrine Sweat Glands Regulate Perspiration in a Ligand-Dependent Manner.,2023,10.1016/j.xjidi.2023.100196,https://pubmed.ncbi.nlm.nih.gov/37533582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR51A7,ENSG00000176895,Neither,38069004,Exploring the Potential of Olfactory Receptor Circulating RNA Measurement for Preeclampsia Prediction and Its Linkage to Mild Gestational Hypothyroidism.,2023,10.3390/ijms242316681,https://pubmed.ncbi.nlm.nih.gov/38069004/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR51A7,ENSG00000176895,Neither,34864818,Association of low-frequency and rare coding variants with information processing speed.,2021,10.1038/s41398-021-01736-6,https://pubmed.ncbi.nlm.nih.gov/34864818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR51A7,ENSG00000176895,Neither,31057674,"Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes.",2019,10.1186/s12263-019-0635-9,https://pubmed.ncbi.nlm.nih.gov/31057674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR51I2,ENSG00000187918,Neither,34337005,A Genome-Wide Association Study of Age-Related Hearing Impairment in Middle- and Old-Aged Chinese Twins.,2021,10.1155/2021/3629624,https://pubmed.ncbi.nlm.nih.gov/34337005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR51Q1,ENSG00000167360,Neither,34573430,Whole-Genome Profiles of Malay Colorectal Cancer Patients with Intact MMR Proteins.,2021,10.3390/genes12091448,https://pubmed.ncbi.nlm.nih.gov/34573430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR51Q1,ENSG00000167360,Neither,28099906,"Genomic characteristics of pancreatic squamous cell carcinoma, an investigation by using high throughput sequencing after in-solution hybrid capture.",2017,10.18632/oncotarget.14678,https://pubmed.ncbi.nlm.nih.gov/28099906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR51Q1,ENSG00000167360,Neither,28729637,Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes.,2017,10.1038/s41598-017-06158-3,https://pubmed.ncbi.nlm.nih.gov/28729637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR51S1,ENSG00000176922,Neither,41409427,Genomics-driven drug repurposing and novel targets identification for sickle cell disease in Saudi patients.,2025,10.3389/fbinf.2025.1671626,https://pubmed.ncbi.nlm.nih.gov/41409427/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR51S1,ENSG00000176922,Neither,36978520,Comparative Analysis of Olfactory Receptor Repertoires Sheds Light on the Diet Adaptation of the Bamboo-Eating Giant Panda Based on the Chromosome-Level Genome.,2023,10.3390/ani13060979,https://pubmed.ncbi.nlm.nih.gov/36978520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR52D1,ENSG00000181609,Neither,34337005,A Genome-Wide Association Study of Age-Related Hearing Impairment in Middle- and Old-Aged Chinese Twins.,2021,10.1155/2021/3629624,https://pubmed.ncbi.nlm.nih.gov/34337005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR52E2,ENSG00000176787,Neither,32726413,Breed Differences in Dog Cognition Associated with Brain-Expressed Genes and Neurological Functions.,2020,10.1093/icb/icaa112,https://pubmed.ncbi.nlm.nih.gov/32726413/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR52E4,ENSG00000180974,Neither,42019310,Characterization of morphological development and olfactory receptor genes in the olfactory system of red-eared slider (Trachemys scripta elegans).,2026,10.1016/j.cbd.2026.101835,https://pubmed.ncbi.nlm.nih.gov/42019310/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR52E4,ENSG00000180974,Neither,40711514,Identification and functional annotation of candidate genes and transcription factors associated with reproductive traits to Nelore bulls: new insights from GWAS and post-GWAS analysis.,2025,10.1007/s11250-025-04558-6,https://pubmed.ncbi.nlm.nih.gov/40711514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR52E4,ENSG00000180974,Neither,33559847,Potential biomarkers and lncRNA-mRNA regulatory networks in invasive growth hormone-secreting pituitary adenomas.,2021,10.1007/s40618-021-01510-x,https://pubmed.ncbi.nlm.nih.gov/33559847/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR52E4,ENSG00000180974,Neither,30402224,Identification of 26 novel loci that confer susceptibility to early-onset coronary artery disease in a Japanese population.,2018,10.3892/br.2018.1152,https://pubmed.ncbi.nlm.nih.gov/30402224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR52E4,ENSG00000180974,Neither,29930801,"Identification of nine genes as novel susceptibility loci for early-onset ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage.",2018,10.3892/br.2018.1104,https://pubmed.ncbi.nlm.nih.gov/29930801/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR52E4,ENSG00000180974,Neither,30226566,"Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease.",2018,10.3892/ijmm.2018.3852,https://pubmed.ncbi.nlm.nih.gov/30226566/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR52E6,ENSG00000205409,Neither,33559847,Potential biomarkers and lncRNA-mRNA regulatory networks in invasive growth hormone-secreting pituitary adenomas.,2021,10.1007/s40618-021-01510-x,https://pubmed.ncbi.nlm.nih.gov/33559847/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR52E8,ENSG00000183269,Neither,42162228,Structural basis of the sweat odorant HMHA recognition by the human odorant receptor OR52E8.,2026,10.1038/s42003-026-10317-6,https://pubmed.ncbi.nlm.nih.gov/42162228/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR52E8,ENSG00000183269,Neither,33559847,Potential biomarkers and lncRNA-mRNA regulatory networks in invasive growth hormone-secreting pituitary adenomas.,2021,10.1007/s40618-021-01510-x,https://pubmed.ncbi.nlm.nih.gov/33559847/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR52H1,ENSG00000181616,Neither,42515885,"Identification of COX7B, GLRX5, and OR52H1 as Vascular Endothelial Injury-associated Biomarkers in Gestational Diabetes Mellitus.",2026,10.2174/0109298673497893260708194320,https://pubmed.ncbi.nlm.nih.gov/42515885/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR52H1,ENSG00000181616,Neither,41965838,Genome-wide investigation of synthetic rescue interactions in Alzheimer's disease implicates glial lipid and sterol metabolism.,2026,10.1186/s13195-026-02009-4,https://pubmed.ncbi.nlm.nih.gov/41965838/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR52L1,ENSG00000183313,Neither,34070492,"Identification of Novel Genomic-Variant Patterns of OR56A5, OR52L1, and CTSD in Retinitis Pigmentosa Patients by Whole-Exome Sequencing.",2021,10.3390/ijms22115594,https://pubmed.ncbi.nlm.nih.gov/34070492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR52L1,ENSG00000183313,Neither,34031191,Association of SUMOylation Pathway Genes With Stroke in a Genome-Wide Association Study in India.,2021,10.1212/wnl.0000000000012258,https://pubmed.ncbi.nlm.nih.gov/34031191/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR52L1,ENSG00000183313,Neither,23656994,Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain.,2013,10.1097/nen.0b013e318294fd76,https://pubmed.ncbi.nlm.nih.gov/23656994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR56A1,ENSG00000180934,Neither,37610843,Altered G-Protein Transduction Protein Gene Expression in the Testis of Infertile Patients with Nonobstructive Azoospermia.,2023,10.1089/dna.2023.0189,https://pubmed.ncbi.nlm.nih.gov/37610843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR56A5,ENSG00000188691,Neither,34070492,"Identification of Novel Genomic-Variant Patterns of OR56A5, OR52L1, and CTSD in Retinitis Pigmentosa Patients by Whole-Exome Sequencing.",2021,10.3390/ijms22115594,https://pubmed.ncbi.nlm.nih.gov/34070492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR5A1,ENSG00000172320,Neither,32031213,Functional Architecture of Deleterious Genetic Variants in the Genome of a Wrangel Island Mammoth.,2020,10.1093/gbe/evz279,https://pubmed.ncbi.nlm.nih.gov/32031213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR5A1,ENSG00000172320,Neither,34827404,African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations.,2021,10.3390/brainsci11111405,https://pubmed.ncbi.nlm.nih.gov/34827404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR5A1,ENSG00000172320,Neither,36625229,Genetic variation in the human olfactory receptor OR5AN1 associates with the perception of musks.,2023,10.1093/chemse/bjac037,https://pubmed.ncbi.nlm.nih.gov/36625229/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR5A1,ENSG00000172320,Neither,35113854,From musk to body odor: Decoding olfaction through genetic variation.,2022,10.1371/journal.pgen.1009564,https://pubmed.ncbi.nlm.nih.gov/35113854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR5AC2,ENSG00000196578,Neither,42768936,A Photoaffinity Probe for S‑Guanylation Posttranslational Modification to Identify Its Interacting Proteins.,2026,10.1002/ardp.70345,https://pubmed.ncbi.nlm.nih.gov/42768936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR5B21,ENSG00000198283,Neither,34917897,Olfactory receptor 5B21 drives breast cancer metastasis.,2021,10.1016/j.isci.2021.103519,https://pubmed.ncbi.nlm.nih.gov/34917897/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR5C1,ENSG00000148215,Neither,40972435,Characterizing the mutational landscape of sinonasal squamous cell carcinoma using whole-exome sequencing.,2025,10.1016/j.oraloncology.2025.107694,https://pubmed.ncbi.nlm.nih.gov/40972435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR5H14,ENSG00000236032,Neither,27902461,"Whole exome sequencing in 75 high-risk families with validation and replication in independent case-control studies identifies TANGO2, OR5H14, and CHAD as new prostate cancer susceptibility genes.",2017,10.18632/oncotarget.13646,https://pubmed.ncbi.nlm.nih.gov/27902461/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR5H6,ENSG00000230301,Neither,35004728,Circulating Placental Alkaline Phosphatase Expressing Exosomes in Maternal Blood Showed Temporal Regulation of Placental Genes.,2021,10.3389/fmed.2021.758971,https://pubmed.ncbi.nlm.nih.gov/35004728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR5H6,ENSG00000230301,Neither,35205299,Genomic Diversity Profiling and Breed-Specific Evolutionary Signatures of Selection in Arunachali Yak.,2022,10.3390/genes13020254,https://pubmed.ncbi.nlm.nih.gov/35205299/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR5M11,ENSG00000255223,Neither,42829446,Cooperation between Adh and OR5M11 contributes to the lung pathogenicity of Actinobacillus pleuropneumoniae by facilitating the NLRP3-mediated inflammatory response.,2026,10.1186/s13567-026-01845-4,https://pubmed.ncbi.nlm.nih.gov/42829446/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR5M11,ENSG00000255223,Neither,35274020,Sperm Transcripts Associated With Odorant Binding and Olfactory Transduction Pathways Are Altered in Breeding Bulls Producing Poor-Quality Semen.,2022,10.3389/fvets.2022.799386,https://pubmed.ncbi.nlm.nih.gov/35274020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR5M11,ENSG00000255223,Neither,27046446,Adh enhances Actinobacillus pleuropneumoniae pathogenicity by binding to OR5M11 and activating p38 which induces apoptosis of PAMs and IL-8 release.,2016,10.1038/srep24058,https://pubmed.ncbi.nlm.nih.gov/27046446/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR5V1,ENSG00000243729,Neither,41570820,Identification of Or5v1/Olfr110 as an oxylipin receptor and anti-obesity target.,2026,10.1016/j.cell.2025.12.016,https://pubmed.ncbi.nlm.nih.gov/41570820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR5V1,ENSG00000243729,Neither,36817779,Exome-wide analysis identify multiple variations in olfactory receptor genes (OR12D2 and OR5V1) associated with autism spectrum disorder in Saudi females.,2023,10.3389/fmed.2023.1051039,https://pubmed.ncbi.nlm.nih.gov/36817779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR5V1,ENSG00000243729,Neither,36812610,Machine learning approaches to predict age from accelerometer records of physical activity at biobank scale.,2023,10.1371/journal.pdig.0000176,https://pubmed.ncbi.nlm.nih.gov/36812610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR5V1,ENSG00000243729,Neither,30108155,Genome-wide association study identifies novel recessive genetic variants for high TGs in an Arab population.,2018,10.1194/jlr.p080218,https://pubmed.ncbi.nlm.nih.gov/30108155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR5V1,ENSG00000243729,Neither,17684544,Systematic association mapping identifies NELL1 as a novel IBD disease gene.,2007,10.1371/journal.pone.0000691,https://pubmed.ncbi.nlm.nih.gov/17684544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR6A2,ENSG00000184933,Neither,42073225,"Identification of Key Aroma Compounds Associated with Olfactory Perception and Pleasantness in Processed Ginseng Products: Insights from GC-MS, Flavoromics, and Computational Modeling.",2026,10.3390/foods15081337,https://pubmed.ncbi.nlm.nih.gov/42073225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR6A2,ENSG00000184933,Neither,41223038,Targeting olfactory receptor 2 on monocytes for cardioprotection against myocardial ischaemia-reperfusion injury via NR4A1-mediated mitochondrial fission.,2025,10.1093/cvr/cvaf232,https://pubmed.ncbi.nlm.nih.gov/41223038/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR6A2,ENSG00000184933,Neither,41473953,Olfr2 Promotes Recruitment of Monocytes via CX3CR1 in Abdominal Aortic Aneurysm.,2026,10.1161/circresaha.125.326591,https://pubmed.ncbi.nlm.nih.gov/41473953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR6A2,ENSG00000184933,Neither,42066673,From odorant perception to stress resilience: Transcriptomic insights into olfactory receptor-driven neuromodulation and antidepressant-like effects of linalyl acetate.,2026,10.1016/j.biopha.2026.119446,https://pubmed.ncbi.nlm.nih.gov/42066673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR6A2,ENSG00000184933,Neither,35283015,Odorant receptors in macrophages: potential targets for atherosclerosis.,2022,10.1016/j.it.2022.02.006,https://pubmed.ncbi.nlm.nih.gov/35283015/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR6A2,ENSG00000184933,Neither,36311776,Olfactory receptors in macrophages and inflammation.,2022,10.3389/fimmu.2022.1029244,https://pubmed.ncbi.nlm.nih.gov/36311776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR6A2,ENSG00000184933,Neither,35025664,Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production.,2022,10.1126/science.abg3067,https://pubmed.ncbi.nlm.nih.gov/35025664/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR6A2,ENSG00000184933,Neither,28454466,Identification of molecular characteristics induced by radiotherapy in rectal cancer based on microarray data.,2017,10.3892/ol.2017.5750,https://pubmed.ncbi.nlm.nih.gov/28454466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR6A2,ENSG00000184933,Neither,14983052,The human olfactory receptor gene family.,2004,10.1073/pnas.0307882100,https://pubmed.ncbi.nlm.nih.gov/14983052/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR6B1,ENSG00000221813,Neither,39350044,Mutational signatures in 175 Chinese gastric cancer patients.,2024,10.1186/s12885-024-12968-2,https://pubmed.ncbi.nlm.nih.gov/39350044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR6B1,ENSG00000221813,Neither,40747002,Population Genomic Analysis Provides Insights Into the Evolution and Conservation of Two Critically Endangered Musk Deer Species.,2025,10.1111/eva.70134,https://pubmed.ncbi.nlm.nih.gov/40747002/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR6B2,ENSG00000182083,Neither,42141086,Insights into protein synthesis dynamics of gilts from the same genetic background and age differing in protein deposition.,2026,10.1038/s41598-026-52194-3,https://pubmed.ncbi.nlm.nih.gov/42141086/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR6B2,ENSG00000182083,Neither,32603211,Immunocytochemical Localization of Olfactory-signaling Molecules in Human and Rat Spermatozoa.,2020,10.1369/0022155420939833,https://pubmed.ncbi.nlm.nih.gov/32603211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR6F1,ENSG00000169214,Neither,41057920,Genomic landscape of cancer driver genes in Omani breast cancers: a pilot study.,2025,10.1186/s13058-025-02133-3,https://pubmed.ncbi.nlm.nih.gov/41057920/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR6F1,ENSG00000169214,Neither,38474024,Transcriptomic Signatures of Neuronally Derived Extracellular Vesicles Reveal the Presence of Olfactory Receptors in Clinical Samples from Traumatic Brain Injury Patients.,2024,10.3390/ijms25052777,https://pubmed.ncbi.nlm.nih.gov/38474024/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,40687083,Olfactory training in specific anosmia to androstenone and its association with genetic variations of OR7D4.,2025,10.1016/j.ibneur.2025.06.017,https://pubmed.ncbi.nlm.nih.gov/40687083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,39852128,Identification of Olfactory Receptors Responding to Androstenone and the Key Structure Determinant in Domestic Pig.,2024,10.3390/cimb47010013,https://pubmed.ncbi.nlm.nih.gov/39852128/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,40428486,"The New Aristocrat of Wuyi Rock Tea: Chemical Basis of the Unique Aroma Quality of ""Laocong Shuixian"".",2025,10.3390/foods14101706,https://pubmed.ncbi.nlm.nih.gov/40428486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,32896801,The expression of androstenone receptor (OR7D4) in vomeronasal organ and olfactory epithelium of horses.,2021,10.1016/j.domaniend.2020.106535,https://pubmed.ncbi.nlm.nih.gov/32896801/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,41395915,Diversity in chemosensory receptor genes in dogs and wolves: degeneration of the olfactory receptor gene repertoire in the brachycephalic Pug.,2025,10.1093/chemse/bjaf062,https://pubmed.ncbi.nlm.nih.gov/41395915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,39747985,Genome-scale evolution in local populations of wild chimpanzees.,2025,10.1038/s41598-024-84163-z,https://pubmed.ncbi.nlm.nih.gov/39747985/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,35903357,Landscape of Variability in Chemosensory Genes Associated With Dietary Preferences in Indian Population: Analysis of 1029 Indian Genomes.,2022,10.3389/fgene.2022.878134,https://pubmed.ncbi.nlm.nih.gov/35903357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,29462498,Odorant Receptor 7D4 Activation Dynamics.,2018,10.1002/anie.201713065,https://pubmed.ncbi.nlm.nih.gov/29462498/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,35113854,From musk to body odor: Decoding olfaction through genetic variation.,2022,10.1371/journal.pgen.1009564,https://pubmed.ncbi.nlm.nih.gov/35113854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,29235485,Quantification of interacting cognate odorants with olfactory receptors in nanovesicles.,2017,10.1038/s41598-017-16997-9,https://pubmed.ncbi.nlm.nih.gov/29235485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,29246659,"Bayesian informed evidence against modulation of androstadienone-effects by genotypic receptor variants and participant sex: A study assessing Stroop interference control, mood and olfaction.",2018,10.1016/j.yhbeh.2017.12.003,https://pubmed.ncbi.nlm.nih.gov/29246659/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,26072518,Global Survey of Variation in a Human Olfactory Receptor Gene Reveals Signatures of Non-Neutral Evolution.,2015,10.1093/chemse/bjv030,https://pubmed.ncbi.nlm.nih.gov/26072518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,22567099,Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone.,2012,10.1371/journal.pone.0035259,https://pubmed.ncbi.nlm.nih.gov/22567099/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,22362865,A genome-wide study on the perception of the odorants androstenone and galaxolide.,2012,10.1093/chemse/bjs008,https://pubmed.ncbi.nlm.nih.gov/22362865/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,28440809,A missense polymorphism in the putative pheromone receptor gene VN1R1 is associated with sociosexual behavior.,2017,10.1038/tp.2017.70,https://pubmed.ncbi.nlm.nih.gov/28440809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,19955411,Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates.,2009,10.1073/pnas.0808378106,https://pubmed.ncbi.nlm.nih.gov/19955411/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,25872419,"A novel platform based on immobilized histidine tagged olfactory receptors, for the amperometric detection of an odorant molecule characteristic of boar taint.",2015,10.1016/j.foodchem.2015.03.066,https://pubmed.ncbi.nlm.nih.gov/25872419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,22977065,Genetic analysis of chemosensory traits in human twins.,2012,10.1093/chemse/bjs070,https://pubmed.ncbi.nlm.nih.gov/22977065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,21818152,"Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects.",2011,10.1038/oby.2011.239,https://pubmed.ncbi.nlm.nih.gov/21818152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7D4,ENSG00000174667,Neither,17509148,Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray.,2007,10.1186/gb-2007-8-5-r86,https://pubmed.ncbi.nlm.nih.gov/17509148/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7E24,ENSG00000237521,Neither,32560248,Genomic Structural Diversity in Local Goats: Analysis of Copy-Number Variations.,2020,10.3390/ani10061040,https://pubmed.ncbi.nlm.nih.gov/32560248/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR7E24,ENSG00000237521,Neither,28454466,Identification of molecular characteristics induced by radiotherapy in rectal cancer based on microarray data.,2017,10.3892/ol.2017.5750,https://pubmed.ncbi.nlm.nih.gov/28454466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR8A1,ENSG00000196119,Neither,41559780,"A telomere-based prognostic model incorporating E2F1, MYCN, VPS72, CFAP53, OR8A1, and TXNRD1 for hepatocellular carcinoma.",2026,10.1186/s40001-026-03900-4,https://pubmed.ncbi.nlm.nih.gov/41559780/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR8A1,ENSG00000196119,Neither,30450618,Key pathway and gene alterations in the gastric mucosa associated with obesity and obesity-related diabetes.,2019,10.1002/jcb.27976,https://pubmed.ncbi.nlm.nih.gov/30450618/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR8B12,ENSG00000170953,Neither,40724312,Decoding the Molecular Mechanisms of Menthol Isomer Perception Based on Computational Simulations.,2025,10.3390/foods14142494,https://pubmed.ncbi.nlm.nih.gov/40724312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR8B12,ENSG00000170953,Neither,34182925,The plasma peptides of Alzheimer's disease.,2021,10.1186/s12014-021-09320-2,https://pubmed.ncbi.nlm.nih.gov/34182925/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR8B2,ENSG00000284680,Neither,39558362,Genome-wide association analysis of cystatin c and creatinine kidney function in Chinese women.,2024,10.1186/s12920-024-02048-6,https://pubmed.ncbi.nlm.nih.gov/39558362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR8B3,ENSG00000284609,Neither,34182925,The plasma peptides of Alzheimer's disease.,2021,10.1186/s12014-021-09320-2,https://pubmed.ncbi.nlm.nih.gov/34182925/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR8B3,ENSG00000284609,Neither,22952299,Functional reconstitution of olfactory receptor complex on baculovirus.,2012,10.1093/chemse/bjs067,https://pubmed.ncbi.nlm.nih.gov/22952299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR8D1,ENSG00000196341,Neither,42011500,Dissecting olfactory receptor binding pocket gating induced by structurally similar odorants furaneol and sotolone through molecular dynamics simulations.,2026,10.1039/d5cp04757a,https://pubmed.ncbi.nlm.nih.gov/42011500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR8D1,ENSG00000196341,Neither,42705075,Characteristic flavors of different processed Yunnan specialty coffee after hot brewing: From sensory attributes to molecular recognition mechanism.,2026,10.1016/j.foodchem.2026.151050,https://pubmed.ncbi.nlm.nih.gov/42705075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR8D1,ENSG00000196341,Neither,40428486,"The New Aristocrat of Wuyi Rock Tea: Chemical Basis of the Unique Aroma Quality of ""Laocong Shuixian"".",2025,10.3390/foods14101706,https://pubmed.ncbi.nlm.nih.gov/40428486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR8D1,ENSG00000196341,Neither,39852128,Identification of Olfactory Receptors Responding to Androstenone and the Key Structure Determinant in Domestic Pig.,2024,10.3390/cimb47010013,https://pubmed.ncbi.nlm.nih.gov/39852128/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR8D1,ENSG00000196341,Neither,27064787,Impacts of Salmonella enterica Serovar Typhimurium and Its speG Gene on the Transcriptomes of In Vitro M Cells and Caco-2 Cells.,2016,10.1371/journal.pone.0153444,https://pubmed.ncbi.nlm.nih.gov/27064787/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR8G1,ENSG00000197849,Neither,40428486,"The New Aristocrat of Wuyi Rock Tea: Chemical Basis of the Unique Aroma Quality of ""Laocong Shuixian"".",2025,10.3390/foods14101706,https://pubmed.ncbi.nlm.nih.gov/40428486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR8G1,ENSG00000197849,Neither,35737091,Whole-exome sequencing of Indian prostate cancer reveals a novel therapeutic target: POLQ.,2023,10.1007/s00432-022-04111-0,https://pubmed.ncbi.nlm.nih.gov/35737091/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR8G5,ENSG00000255298,Neither,31180460,Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype.,2019,10.1001/jamaneurol.2019.1456,https://pubmed.ncbi.nlm.nih.gov/31180460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR8S1,ENSG00000284723,Neither,34367982,Interactions Between Adiponectin-Pathway Polymorphisms and Obesity on Postmenopausal Breast Cancer Risk Among African American Women: The WHI SHARe Study.,2021,10.3389/fonc.2021.698198,https://pubmed.ncbi.nlm.nih.gov/34367982/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR8S1,ENSG00000284723,Neither,24105470,A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.,2014,10.1093/hmg/ddt488,https://pubmed.ncbi.nlm.nih.gov/24105470/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR9Q2,ENSG00000186513,Neither,42446736,Genome sequencing reveals genes under selection for olfactory transduction in highland sheep.,2026,10.1007/s00438-026-02477-1,https://pubmed.ncbi.nlm.nih.gov/42446736/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR9Q2,ENSG00000186513,Neither,41227707,Molecular Mechanism Analysis of the Activation of Human Olfactory Receptor OR9Q2 by 4-Methylphenol.,2025,10.3390/foods14213738,https://pubmed.ncbi.nlm.nih.gov/41227707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR9Q2,ENSG00000186513,Neither,41361076,Molecular simulation-based 3D structural construction of olfactory receptor with agonist binding.,2025,10.1007/s10822-025-00706-0,https://pubmed.ncbi.nlm.nih.gov/41361076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR9Q2,ENSG00000186513,Neither,25117815,Identification of 33 candidate oncogenes by screening for base-specific mutations.,2014,10.1038/bjc.2014.429,https://pubmed.ncbi.nlm.nih.gov/25117815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,40389292,Novel variant in &lt;i&gt;OTOG&lt;/i&gt; gene in consanguineous family with sensorineural hearing loss.,2025,10.1136/bcr-2024-262338,https://pubmed.ncbi.nlm.nih.gov/40389292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,41291450,Transcriptomic and metabolomic basis of seasonal auditory sensitivity variations in the red-eared slider (Trachemys scripta elegans).,2025,10.1186/s12864-025-12358-3,https://pubmed.ncbi.nlm.nih.gov/41291450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,42121453,Study on the Correlation Between Microbial Community Composition and Flavor of Traditional Ordos Air-Dried Meat.,2026,10.3390/foods15091510,https://pubmed.ncbi.nlm.nih.gov/42121453/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,42287969,"Increased head-turning, hyperactivity and low-penetrance circling behaviour in mice lacking ZPLD1, a protein that scaffolds the cupula to the roof of the ampulla.",2026,10.1016/j.heares.2026.109702,https://pubmed.ncbi.nlm.nih.gov/42287969/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,42702881,TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non-Syndromic Hearing Loss.,2026,10.1002/advs.77543,https://pubmed.ncbi.nlm.nih.gov/42702881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,40565546,Replication of Missense &lt;i&gt;OTOG&lt;/i&gt; Gene Variants in a Brazilian Patient with Menière's Disease.,2025,10.3390/genes16060654,https://pubmed.ncbi.nlm.nih.gov/40565546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,41430327,Genes linked to hearing and vestibular phenotypes in humans and mice: an interspecies systematic review.,2025,10.1186/s40246-025-00891-x,https://pubmed.ncbi.nlm.nih.gov/41430327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,38100419,A role for mutations in &lt;i&gt;AK9&lt;/i&gt; and other genes affecting ependymal cells in idiopathic normal pressure hydrocephalus.,2023,10.1073/pnas.2300681120,https://pubmed.ncbi.nlm.nih.gov/38100419/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,39858607,Novel &lt;i&gt;OTOG&lt;/i&gt; Variants and Clinical Features of Hearing Loss in a Large Japanese Cohort.,2025,10.3390/genes16010060,https://pubmed.ncbi.nlm.nih.gov/39858607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,42032772,Sex-aware genome-wide assessment of de novo variants in autism across coding and noncoding regions.,2026,10.1186/s40246-026-00961-8,https://pubmed.ncbi.nlm.nih.gov/42032772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,40266017,Genetic Risk Factors in Normal Pressure Hydrocephalus: What We Know and What Is Next.,2025,10.1002/mds.30206,https://pubmed.ncbi.nlm.nih.gov/40266017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,40307680,"Analysis of the effect of fecal SDC2, ADHFE1 and PPP2R5C gene methylation test for screening colorectal cancer in the Otog Front Banner.",2025,10.1186/s12876-025-03737-x,https://pubmed.ncbi.nlm.nih.gov/40307680/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,42529085,Improving aboveground biomass estimation in desert steppe using hyperspectral semantic segmentation.,2026,10.3389/fpls.2026.1853466,https://pubmed.ncbi.nlm.nih.gov/42529085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,40682330,Biallelic Mutations in the Otogelin-Like Gene (OTOGL) Associated With Congenital Non-Syndromic Sensorineural Hearing Loss in a Chinese Family.,2025,10.1002/mgg3.70122,https://pubmed.ncbi.nlm.nih.gov/40682330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,38519595,An overload of missense variants in the OTOG gene may drive a higher prevalence of familial Meniere disease in the European population.,2024,10.1007/s00439-024-02643-8,https://pubmed.ncbi.nlm.nih.gov/38519595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,34174893,"OTOGL, a gelforming mucin protein, is nonessential for male germ cell development and spermatogenesis in mice.",2021,10.1186/s12958-021-00779-0,https://pubmed.ncbi.nlm.nih.gov/34174893/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,38894825,Whole Exome Sequencing of Non-Syndromic Hearing Loss Patients.,2024,10.18502/ijph.v53i2.14930,https://pubmed.ncbi.nlm.nih.gov/38894825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,34118384,Prediction and interpretation of rare missense variant in OTOG associated with hearing loss.,2021,10.1016/j.ygeno.2021.06.012,https://pubmed.ncbi.nlm.nih.gov/34118384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,37284494,Recent advances in understanding molecular bases of Ménière's disease.,2023,10.12703/r/12-11,https://pubmed.ncbi.nlm.nih.gov/37284494/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,38860500,Mutation spectrum of hearing loss patients in Northwest China: Identification of 20 novel variants.,2024,10.1002/mgg3.2434,https://pubmed.ncbi.nlm.nih.gov/38860500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,37098928,Tumor Microenvironment CD8 T and Treg Cells-related Genes Signature Distinguishes Distinct Prognosis and Targeted Therapies Response in Endometrial Cancer.,2023,10.1097/cji.0000000000000463,https://pubmed.ncbi.nlm.nih.gov/37098928/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,38823700,No increase of soil wind erosion with the establishment of center pivot irrigation system in Mu-Us sandy land.,2024,10.1016/j.scitotenv.2024.173558,https://pubmed.ncbi.nlm.nih.gov/38823700/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,36565421,Genetic advances in Meniere Disease.,2023,10.1007/s11033-022-08149-8,https://pubmed.ncbi.nlm.nih.gov/36565421/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,35186366,"Human Plague Case Diagnosed in Ningxia Tracked to Animal Reservoirs - Inner Mongolia Autonomous Region, China, 2021.",2021,10.46234/ccdcw2021.267,https://pubmed.ncbi.nlm.nih.gov/35186366/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,30097855,Candidate susceptibility variants in angioimmunoblastic T-cell lymphoma.,2019,10.1007/s10689-018-0099-x,https://pubmed.ncbi.nlm.nih.gov/30097855/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,29976152,A novel locus on mouse chromosome 7 that influences survival after infection with tick-borne encephalitis virus.,2018,10.1186/s12868-018-0438-8,https://pubmed.ncbi.nlm.nih.gov/29976152/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,30947719,Screening of noise-induced hearing loss (NIHL)-associated SNPs and the assessment of its genetic susceptibility.,2019,10.1186/s12940-019-0471-9,https://pubmed.ncbi.nlm.nih.gov/30947719/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOG,ENSG00000188162,Neither,25758224,Otolith tethering in the zebrafish otic vesicle requires Otogelin and α-Tectorin.,2015,10.1242/dev.116632,https://pubmed.ncbi.nlm.nih.gov/25758224/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OVOL3,ENSG00000105261,Neither,42382055,Geniposide activates the transcription of Ndufs8 and enhances PD-L1 blockade for inhibiting growth of osteosarcoma.,2026,10.1016/j.jtcme.2025.04.002,https://pubmed.ncbi.nlm.nih.gov/42382055/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OVOL3,ENSG00000105261,Neither,37033105,"Comprehensive analysis of the expression, prognostic value and biological importance of OVO‑like proteins in clear cell renal cell carcinoma.",2023,10.3892/ol.2023.13765,https://pubmed.ncbi.nlm.nih.gov/37033105/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OVOL3,ENSG00000105261,Neither,34345183,"Comprehensive Analysis of the Expression, Prognosis, and Biological Significance of OVOLs in Breast Cancer.",2021,10.2147/ijgm.s326402,https://pubmed.ncbi.nlm.nih.gov/34345183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OVOL3,ENSG00000105261,Neither,36394757,A novel nomogram associated with regulatory T cells infiltration by weighted gene co-expression network analysis for predicting survival in patients with colon cancer.,2022,10.26355/eurrev_202211_30161,https://pubmed.ncbi.nlm.nih.gov/36394757/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OVOL3,ENSG00000105261,Neither,22737237,Molecular phylogeny of OVOL genes illustrates a conserved C2H2 zinc finger domain coupled by hypervariable unstructured regions.,2012,10.1371/journal.pone.0039399,https://pubmed.ncbi.nlm.nih.gov/22737237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,41998711,Loss of maternal PADI6 disrupts DNA methylation and genomic imprinting maintenance in late preimplantation mouse embryos.,2026,10.1186/s13072-026-00674-1,https://pubmed.ncbi.nlm.nih.gov/41998711/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,41884623,Case Report: Biallelic &lt;i&gt;PADI6&lt;/i&gt; frameshift variants contribute to preimplantation embryonic lethality.,2026,10.3389/fgene.2026.1667814,https://pubmed.ncbi.nlm.nih.gov/41884623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,42278641,Targeting Peptidylarginine Deiminases in Neurons and Astrocytes in Central Nervous System Injury-Effects of Pan-PAD Inhibitor Cl-Amidine in an Oxygen-Glucose Deprivation Model of Ischaemia (OGD/R) and LPS Stimulation In Vitro.,2026,10.3390/ijms27115118,https://pubmed.ncbi.nlm.nih.gov/42278641/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,41465483,Peptidylarginine Deiminases: An Overview of Recent Advances in Citrullination Research.,2025,10.3390/ijms262412060,https://pubmed.ncbi.nlm.nih.gov/41465483/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,41828362,Genetic Mutations and Non-Genomic Dysregulation in Human Preimplantation Embryo Arrest.,2026,10.3390/ijms27052135,https://pubmed.ncbi.nlm.nih.gov/41828362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,39286527,Structural insight into the function of human peptidyl arginine deiminase 6.,2024,10.1016/j.csbj.2024.08.019,https://pubmed.ncbi.nlm.nih.gov/39286527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,42817003,Transcriptomic Dynamics Associated With In Vitro Oocyte Competence in Pigs.,2026,10.1111/rda.70265,https://pubmed.ncbi.nlm.nih.gov/42817003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,40830544,A novel PADI6 splice-site variant induces non-canonical GC-AG splicing and embryonic arrest in humans.,2025,10.1007/s10142-025-01689-9,https://pubmed.ncbi.nlm.nih.gov/40830544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,41845018,Molecular basis of oocyte cytoplasmic lattice assembly.,2026,10.1038/s41586-026-10360-7,https://pubmed.ncbi.nlm.nih.gov/41845018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,38656308,Crystal structure of human peptidylarginine deiminase type VI (PAD6) provides insights into its inactivity.,2024,10.1107/s2052252524002549,https://pubmed.ncbi.nlm.nih.gov/38656308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,39644447,Novel variants in PADI6 genes cause female infertility due to early embryo arrest.,2024,10.1007/s10815-024-03332-1,https://pubmed.ncbi.nlm.nih.gov/39644447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,41832613,Regulation of basal and tumour necrosis factor α-induced fibroblast gene expression by peptidylarginine deiminase 2.,2026,10.1113/jp290391,https://pubmed.ncbi.nlm.nih.gov/41832613/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,38562607,Padi6 expression patterns in buffalo oocytes and preimplantation embryos.,2024,10.1590/1984-3143-ar2023-0146,https://pubmed.ncbi.nlm.nih.gov/38562607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,41986725,Cytoplasmic lattices are megadalton storage complexes in mammalian oocytes.,2026,10.1038/s41586-026-10513-8,https://pubmed.ncbi.nlm.nih.gov/41986725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,38453481,"A maternal-effect Padi6 variant causes nuclear and cytoplasmic abnormalities in oocytes, as well as failure of epigenetic reprogramming and zygotic genome activation in embryos.",2024,10.1101/gad.351238.123,https://pubmed.ncbi.nlm.nih.gov/38453481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,40091361,Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3.,2025,10.1002/advs.202414985,https://pubmed.ncbi.nlm.nih.gov/40091361/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,42426369,Cytoplasmic lattices store developmentally poised degradative and cytoskeletal complexes in mammalian eggs.,2026,10.1038/s41594-026-01843-2,https://pubmed.ncbi.nlm.nih.gov/42426369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,37778376,PADI6: What we know about the elusive fifth member of the peptidyl arginine deiminase family.,2023,10.1098/rstb.2022.0242,https://pubmed.ncbi.nlm.nih.gov/37778376/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,37712067,A novel homozygous variant in PADI6 is associate with human cleavage-stage embryonic arrest.,2023,10.3389/fgene.2023.1243230,https://pubmed.ncbi.nlm.nih.gov/37712067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,42070745,Role of zygotic arrest genes in female meiosis and early embryonic development.,2026,10.1016/j.ydbio.2026.04.019,https://pubmed.ncbi.nlm.nih.gov/42070745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,37194006,Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice.,2023,10.1186/s12958-023-01097-3,https://pubmed.ncbi.nlm.nih.gov/37194006/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,36931261,Assisted oocyte activation does not overcome recurrent embryo developmental problems.,2023,10.1093/humrep/dead051,https://pubmed.ncbi.nlm.nih.gov/36931261/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,32629995,Putative Roles for Peptidylarginine Deiminases in COVID-19.,2020,10.3390/ijms21134662,https://pubmed.ncbi.nlm.nih.gov/32629995/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,35955829,A Pilot Study on Peptidylarginine Deiminases and Protein Deimination in Animal Cancers across Vertebrate Species.,2022,10.3390/ijms23158697,https://pubmed.ncbi.nlm.nih.gov/35955829/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,35563075,Acute Hypoxia Alters Extracellular Vesicle Signatures and the Brain Citrullinome of Naked Mole-Rats (Heterocephalus glaber).,2022,10.3390/ijms23094683,https://pubmed.ncbi.nlm.nih.gov/35563075/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,24440480,Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation.,2014,10.1016/j.bmc.2013.12.064,https://pubmed.ncbi.nlm.nih.gov/24440480/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,27545678,Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest.,2016,10.1016/j.ajhg.2016.06.024,https://pubmed.ncbi.nlm.nih.gov/27545678/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PADI6,ENSG00000276747,Neither,15625577,"cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type VI.",2004,10.18388/abp.2004_3538,https://pubmed.ncbi.nlm.nih.gov/15625577/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE3,ENSG00000204279,Neither,40359694,Cancer-testis antigen expression in canine melanoma and healthy tissues.,2025,10.1016/j.vetimm.2025.110946,https://pubmed.ncbi.nlm.nih.gov/40359694/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE3,ENSG00000204279,Neither,30429015,Detection of autoantibodies against cancer-testis antigens in non-small cell lung cancer.,2018,10.1016/j.lungcan.2018.09.012,https://pubmed.ncbi.nlm.nih.gov/30429015/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE5,ENSG00000158639,Neither,41203637,Single-cell analysis unravels divergent gene signatures shaping seminoma stemness and metastasis.,2025,10.1038/s41420-025-02802-4,https://pubmed.ncbi.nlm.nih.gov/41203637/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE5,ENSG00000158639,Neither,39980969,A telomere-related signature for predicting prognosis and assessing immune microenvironment in osteosarcoma.,2024,10.3389/fphar.2024.1532610,https://pubmed.ncbi.nlm.nih.gov/39980969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE5,ENSG00000158639,Neither,37256926,Single-Cell Evolutionary Analysis Reveals Drivers of Plasticity and Mediators of Chemoresistance in Small Cell Lung Cancer.,2023,10.1158/1541-7786.mcr-22-0881,https://pubmed.ncbi.nlm.nih.gov/37256926/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE5,ENSG00000158639,Neither,36157484,Single-cell landscape analysis reveals distinct regression trajectories and novel prognostic biomarkers in primary neuroblastoma.,2022,10.1016/j.gendis.2021.12.020,https://pubmed.ncbi.nlm.nih.gov/36157484/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE5,ENSG00000158639,Neither,28742074,Untargeted screening for novel autoantibodies with prognostic value in first-episode psychosis.,2017,10.1038/tp.2017.160,https://pubmed.ncbi.nlm.nih.gov/28742074/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE5,ENSG00000158639,Neither,22073178,Characterization of intrinsically disordered prostate associated gene (PAGE5) at single residue resolution by NMR spectroscopy.,2011,10.1371/journal.pone.0026633,https://pubmed.ncbi.nlm.nih.gov/22073178/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE5,ENSG00000158639,Neither,23028975,Melanoma-associated cancer-testis antigen 16 (CT16) regulates the expression of apoptotic and antiapoptotic genes and promotes cell survival.,2012,10.1371/journal.pone.0045382,https://pubmed.ncbi.nlm.nih.gov/23028975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE5,ENSG00000158639,Neither,26747525,IL-10 and integrin signaling pathways are associated with head and neck cancer progression.,2016,10.1186/s12864-015-2359-6,https://pubmed.ncbi.nlm.nih.gov/26747525/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE5,ENSG00000158639,Neither,19768387,"An intraresidual i(HCA)CO(CA)NH experiment for the assignment of main-chain resonances in 15N, 13C labeled proteins.",2009,10.1007/s10858-009-9373-4,https://pubmed.ncbi.nlm.nih.gov/19768387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,41857514,Panx3 deficiency in mice impairs bone fracture healing and causes transient hypoglycemia in neonatal animals.,2026,10.1186/s10020-026-01458-9,https://pubmed.ncbi.nlm.nih.gov/41857514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,42127103,Human pannexin mutations and their implications in erosive osteoarthritis.,2026,10.1073/pnas.2535302123,https://pubmed.ncbi.nlm.nih.gov/42127103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,42835090,Pannexin 3-mediated adenosine triphosphate release from pre-osteoblasts promotes osteoblast differentiation through P2X4 receptor activation.,2026,10.3389/fphys.2026.1880201,https://pubmed.ncbi.nlm.nih.gov/42835090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,41051983,Pannexins in the vasculature.,2025,10.1152/ajpheart.00510.2025,https://pubmed.ncbi.nlm.nih.gov/41051983/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,40386290,Severe osteoarthritis in aged PANX3 knockout mice: implications for a novel primary osteoarthritis model.,2025,10.1093/jbmrpl/ziaf057,https://pubmed.ncbi.nlm.nih.gov/40386290/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,39560179,Pannexin 1 and pannexin 3 differentially regulate the cancer cell properties of cutaneous squamous cell carcinoma.,2025,10.1113/jp286172,https://pubmed.ncbi.nlm.nih.gov/39560179/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,40441467,Panx3 mediates ferroptosis via the AKT/mTOR signaling pathway in oral squamous cell carcinoma.,2025,10.1016/j.cellsig.2025.111908,https://pubmed.ncbi.nlm.nih.gov/40441467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,41922630,Hydrostatic pressure promotes odontoblast differentiation via PIEZO1-dependent activation of RUNX2 and WNT16 in SHED.,2026,10.1038/s41598-026-46415-y,https://pubmed.ncbi.nlm.nih.gov/41922630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,40909173,Pannexin channels in inflammation and tumorigenesis.,2025,10.3389/fcell.2025.1647765,https://pubmed.ncbi.nlm.nih.gov/40909173/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,38289985,Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress.,2024,10.1126/scisignal.adg2622,https://pubmed.ncbi.nlm.nih.gov/38289985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,40075313,Role of arachidonic acid metabolism in osteosarcoma prognosis by integrating WGCNA and bioinformatics analysis.,2025,10.1186/s12885-024-13278-3,https://pubmed.ncbi.nlm.nih.gov/40075313/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,39733924,"Prrx2, the paired-related homeobox transcription factor, functions as a potential regulator of pannexin 3 expression in odontoblast differentiation.",2025,10.1016/j.job.2024.100601,https://pubmed.ncbi.nlm.nih.gov/39733924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,38992988,Contribution of inwardly rectifying potassium channel 4.1 in orofacial neuropathic pain: Regulation of pannexin 3 via the reactive oxygen species-activated P38 MAPK signal pathway.,2024,10.1111/ejn.16458,https://pubmed.ncbi.nlm.nih.gov/38992988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,39721314,Cryo-EM structure of the human Pannexin-3 channel.,2025,10.1016/j.bbrc.2024.151227,https://pubmed.ncbi.nlm.nih.gov/39721314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,38966281,The whole transcriptome analysis using FFPE and fresh tissue samples identifies the molecular fingerprint of osteosarcoma.,2024,10.3389/ebm.2024.10161,https://pubmed.ncbi.nlm.nih.gov/38966281/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,40243895,Loosening the Lid on Shoulder Osteoarthritis: How the Transcriptome and Metabolic Syndrome Correlate with End-Stage Disease.,2025,10.3390/ijms26073145,https://pubmed.ncbi.nlm.nih.gov/40243895/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,39441379,Malignant epithelioid neoplasm with GLI1 gene rearrangement (PANX3::GLI1 transcript) and MDM2 gene amplification.,2025,10.1007/s00428-024-03949-8,https://pubmed.ncbi.nlm.nih.gov/39441379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,38499500,Pannexin 3 deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running.,2024,10.1002/jor.25830,https://pubmed.ncbi.nlm.nih.gov/38499500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,38038973,Skin in the game: pannexin channels in healthy and cancerous skin.,2023,10.1042/bcj20230176,https://pubmed.ncbi.nlm.nih.gov/38038973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,34250568,Pannexin 3 channels in health and disease.,2021,10.1007/s11302-021-09805-7,https://pubmed.ncbi.nlm.nih.gov/34250568/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,38355795,Bone marrow plasma cells require P2RX4 to sense extracellular ATP.,2024,10.1038/s41586-024-07047-2,https://pubmed.ncbi.nlm.nih.gov/38355795/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,38272164,Integrated histopathology and transcriptome metabolome profiling reveal the toxicity mechanism of phenazine-1-carboxylic acid in zebrafish.,2024,10.1016/j.envpol.2024.123402,https://pubmed.ncbi.nlm.nih.gov/38272164/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,37968314,Bee gomogenat enhances the healing process of diabetic wounds by orchestrating the connexin-pannexin gap junction proteins in streptozotocin-induced diabetic mice.,2023,10.1038/s41598-023-47206-5,https://pubmed.ncbi.nlm.nih.gov/37968314/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,35163442,Mechanisms of Pannexin 1 (PANX1) Channel Mechanosensitivity and Its Pathological Roles.,2022,10.3390/ijms23031523,https://pubmed.ncbi.nlm.nih.gov/35163442/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,34975840,Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells.,2021,10.3389/fimmu.2021.750480,https://pubmed.ncbi.nlm.nih.gov/34975840/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,36438559,Pannexin1 channels-a potential therapeutic target in inflammation.,2022,10.3389/fcell.2022.1020826,https://pubmed.ncbi.nlm.nih.gov/36438559/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,26138248,Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis.,2015,10.1007/s00109-015-1311-1,https://pubmed.ncbi.nlm.nih.gov/26138248/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,24600404,The pannexins: past and present.,2014,10.3389/fphys.2014.00058,https://pubmed.ncbi.nlm.nih.gov/24600404/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PANX3,ENSG00000154143,Neither,24839011,Mechanosensitive release of adenosine 5'-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain.,2014,10.1002/glia.22695,https://pubmed.ncbi.nlm.nih.gov/24839011/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA13,ENSG00000239389,Neither,38862462,Comprehensive analysis of genetic risk loci uncovers novel candidate genes and pathways in the comorbidity between depression and Alzheimer's disease.,2024,10.1038/s41398-024-02968-y,https://pubmed.ncbi.nlm.nih.gov/38862462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA13,ENSG00000239389,Neither,35117749,Lung cancer A549 cells suppressed with overexpressed HNF1B or PCDHA13 inhibited PI3K/AKT phosphorylation.,2020,10.21037/tcr-20-1727,https://pubmed.ncbi.nlm.nih.gov/35117749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA13,ENSG00000239389,Neither,25418975,Global methylation silencing of clustered proto-cadherin genes in cervical cancer: serving as diagnostic markers comparable to HPV.,2015,10.1002/cam4.335,https://pubmed.ncbi.nlm.nih.gov/25418975/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA13,ENSG00000239389,Neither,28530678,The complex genetics of hypoplastic left heart syndrome.,2017,10.1038/ng.3870,https://pubmed.ncbi.nlm.nih.gov/28530678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA13,ENSG00000239389,Neither,21962230,MiR-185 targets the DNA methyltransferases 1 and regulates global DNA methylation in human glioma.,2011,10.1186/1476-4598-10-124,https://pubmed.ncbi.nlm.nih.gov/21962230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA3,ENSG00000255408,Neither,42089102,A risk scoring model for lung squamous cell carcinoma based on epithelial-mesenchymal transition-related genes: an integrative analysis of prognosis and immune infiltration characteristics.,2026,10.7717/peerj.21117,https://pubmed.ncbi.nlm.nih.gov/42089102/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA3,ENSG00000255408,Neither,34086268,Protocadherin alpha 3 inhibits lung squamous cell carcinoma metastasis and epithelial-mesenchymal transition.,2022,10.1007/s13258-021-01113-z,https://pubmed.ncbi.nlm.nih.gov/34086268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA3,ENSG00000255408,Neither,33751805,LncRNA-ZXF1 stabilizes P21 expression in endometrioid endometrial carcinoma by inhibiting ubiquitination-mediated degradation and regulating the miR-378a-3p/PCDHA3 axis.,2022,10.1002/1878-0261.12940,https://pubmed.ncbi.nlm.nih.gov/33751805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA3,ENSG00000255408,Neither,34859219,Maternal immune activation downregulates schizophrenia genes in the foetal mouse brain.,2021,10.1093/braincomms/fcab275,https://pubmed.ncbi.nlm.nih.gov/34859219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA3,ENSG00000255408,Neither,33756103,Novel ultra-rare exonic variants identified in a founder population implicate cadherins in schizophrenia.,2021,10.1016/j.neuron.2021.03.004,https://pubmed.ncbi.nlm.nih.gov/33756103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA3,ENSG00000255408,Neither,37329382,miR-218-5p and miR-320a-5p as Biomarkers for Brain Disorders: Focus on the Major Depressive Disorder and Parkinson's Disease.,2023,10.1007/s12035-023-03391-y,https://pubmed.ncbi.nlm.nih.gov/37329382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA7,ENSG00000204963,Neither,42382379,Focal Polycomb-Mediated Repression of Neuronal Identity and Synaptic Maintenance Genes in Aging Neurons.,2026,10.7759/cureus.111824,https://pubmed.ncbi.nlm.nih.gov/42382379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA7,ENSG00000204963,Neither,42792926,Genome-Wide Analysis of Alternative Splicing Identifies a Prognostic Signature in ER-Positive Breast Cancer.,2026,10.3390/genes17091032,https://pubmed.ncbi.nlm.nih.gov/42792926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA7,ENSG00000204963,Neither,38862462,Comprehensive analysis of genetic risk loci uncovers novel candidate genes and pathways in the comorbidity between depression and Alzheimer's disease.,2024,10.1038/s41398-024-02968-y,https://pubmed.ncbi.nlm.nih.gov/38862462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA7,ENSG00000204963,Neither,36053093,"Novel Insights into the Etiology, Genetics, and Embryology of Hypoplastic Left Heart Syndrome.",2022,10.1177/21501351221102961,https://pubmed.ncbi.nlm.nih.gov/36053093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA7,ENSG00000204963,Neither,32366953,Cis-effects on gene expression in the human prenatal brain associated with genetic risk for neuropsychiatric disorders.,2021,10.1038/s41380-020-0743-3,https://pubmed.ncbi.nlm.nih.gov/32366953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA7,ENSG00000204963,Neither,32398722,Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders.,2021,10.1038/s41380-020-0705-9,https://pubmed.ncbi.nlm.nih.gov/32398722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA7,ENSG00000204963,Neither,32171843,Targeted gene expression study using TaqMan low density array to gain insights into venous thrombo-embolism (VTE) pathogenesis at high altitude.,2020,10.1016/j.bcmd.2020.102421,https://pubmed.ncbi.nlm.nih.gov/32171843/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA8,ENSG00000204962,Neither,42794468,Targeted 3.34-Million CpG Site Sequencing Reveals Preliminary Cord Blood Epigenetic Alterations of Autism Spectrum Disorder: A Pilot Study Highlighting the &lt;i&gt;PCDHA1&lt;/i&gt;-&lt;i&gt;PCDHA8&lt;/i&gt; Cluster.,2026,10.3390/ijms27188038,https://pubmed.ncbi.nlm.nih.gov/42794468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA8,ENSG00000204962,Neither,41208545,Rare Genetic Variants of Cell Adhesion Molecules in Transgender Men Suggest a Potential Role in Gender Dysphoria.,2025,10.1159/000549011,https://pubmed.ncbi.nlm.nih.gov/41208545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA8,ENSG00000204962,Neither,38862462,Comprehensive analysis of genetic risk loci uncovers novel candidate genes and pathways in the comorbidity between depression and Alzheimer's disease.,2024,10.1038/s41398-024-02968-y,https://pubmed.ncbi.nlm.nih.gov/38862462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA8,ENSG00000204962,Neither,36836422,Tumor Microenvironment and Genes Affecting the Prognosis of Temozolomide-Treated Glioblastoma.,2023,10.3390/jpm13020188,https://pubmed.ncbi.nlm.nih.gov/36836422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA8,ENSG00000204962,Neither,37092861,Brain transcriptome-wide association study implicates novel risk genes underlying schizophrenia risk.,2023,10.1017/s0033291723000417,https://pubmed.ncbi.nlm.nih.gov/37092861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA8,ENSG00000204962,Neither,32366953,Cis-effects on gene expression in the human prenatal brain associated with genetic risk for neuropsychiatric disorders.,2021,10.1038/s41380-020-0743-3,https://pubmed.ncbi.nlm.nih.gov/32366953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA8,ENSG00000204962,Neither,30531834,Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway.,2019,10.1038/s41388-018-0602-8,https://pubmed.ncbi.nlm.nih.gov/30531834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA8,ENSG00000204962,Neither,21962230,MiR-185 targets the DNA methyltransferases 1 and regulates global DNA methylation in human glioma.,2011,10.1186/1476-4598-10-124,https://pubmed.ncbi.nlm.nih.gov/21962230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA8,ENSG00000204962,Neither,25243798,Copy number variations and susceptibility to lateral temporal epilepsy: a study of 21 pedigrees.,2014,10.1111/epi.12767,https://pubmed.ncbi.nlm.nih.gov/25243798/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA9,ENSG00000204961,Neither,42519381,Congenital heart defects genetic architecture in a small cohort: an integrated approach to prioritizing variants.,2026,10.3389/fcvm.2026.1850208,https://pubmed.ncbi.nlm.nih.gov/42519381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA9,ENSG00000204961,Neither,39774941,Mitotic block and epigenetic repression underlie neurodevelopmental defects and neurobehavioral deficits in congenital heart disease.,2025,10.1038/s41467-024-55741-6,https://pubmed.ncbi.nlm.nih.gov/39774941/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA9,ENSG00000204961,Neither,38467605,PCDHA9 as a candidate gene for amyotrophic lateral sclerosis.,2024,10.1038/s41467-024-46333-5,https://pubmed.ncbi.nlm.nih.gov/38467605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA9,ENSG00000204961,Neither,39407833,Validation of a Paralimbic-Related Subcortical Brain Dysmaturation MRI Score in Infants with Congenital Heart Disease.,2024,10.3390/jcm13195772,https://pubmed.ncbi.nlm.nih.gov/39407833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA9,ENSG00000204961,Neither,37372085,Towards a More Comprehensive Picture of the MicroRNA-23a/b-3p Impact on Impaired Male Fertility.,2023,10.3390/biology12060800,https://pubmed.ncbi.nlm.nih.gov/37372085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA9,ENSG00000204961,Neither,37610864,A Prognostic Model for Prostate Cancer Patients Based on Two DNA Damage Response Mutation-Related Immune Genes.,2024,10.1089/cbr.2023.0033,https://pubmed.ncbi.nlm.nih.gov/37610864/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA9,ENSG00000204961,Neither,36053093,"Novel Insights into the Etiology, Genetics, and Embryology of Hypoplastic Left Heart Syndrome.",2022,10.1177/21501351221102961,https://pubmed.ncbi.nlm.nih.gov/36053093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA9,ENSG00000204961,Neither,34890862,Placental and fetal characteristics of the Ohia mouse line recapitulate outcomes in human hypoplastic left heart syndrome.,2022,10.1016/j.placenta.2021.12.001,https://pubmed.ncbi.nlm.nih.gov/34890862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA9,ENSG00000204961,Neither,34803456,Analyzing differentially expressed genes and pathways of Bex2-deficient mouse lung via RNA-Seq.,2021,10.3906/biy-2104-4,https://pubmed.ncbi.nlm.nih.gov/34803456/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA9,ENSG00000204961,Neither,28530678,The complex genetics of hypoplastic left heart syndrome.,2017,10.1038/ng.3870,https://pubmed.ncbi.nlm.nih.gov/28530678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA9,ENSG00000204961,Neither,29569026,The Genetic Landscape of Hypoplastic Left Heart Syndrome.,2018,10.1007/s00246-018-1861-4,https://pubmed.ncbi.nlm.nih.gov/29569026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA9,ENSG00000204961,Neither,31514070,Comparative transcriptome analysis to elucidate the therapeutic mechanism of colchicine against atrial fibrillation.,2019,10.1016/j.biopha.2019.109422,https://pubmed.ncbi.nlm.nih.gov/31514070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA9,ENSG00000204961,Neither,15585362,Effect of single wall carbon nanotubes on human HEK293 cells.,2005,10.1016/j.toxlet.2004.08.015,https://pubmed.ncbi.nlm.nih.gov/15585362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB13,ENSG00000187372,Neither,42653334,Whole-Transcriptome Sequencing and ceRNA Network Analysis of the Hypothalamus During the Follicular Phase in High- and Low-Fecundity Xinjiang Goats.,2026,10.3390/ijms27167330,https://pubmed.ncbi.nlm.nih.gov/42653334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB13,ENSG00000187372,Neither,30658436,FOSB⁻PCDHB13 Axis Disrupts the Microtubule Network in Non-Small Cell Lung Cancer.,2019,10.3390/cancers11010107,https://pubmed.ncbi.nlm.nih.gov/30658436/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB3,ENSG00000113205,Neither,37508616,Innovative Family-Based Genetically Informed Series of Analyses of Whole-Exome Data Supports Likely Inheritance for Grammar in Children with Specific Language Impairment.,2023,10.3390/children10071119,https://pubmed.ncbi.nlm.nih.gov/37508616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB3,ENSG00000113205,Neither,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB3,ENSG00000113205,Neither,35480311,Association of DNA Methylation Patterns in 7 Novel Genes With Ischemic Stroke in the Northern Chinese Population.,2022,10.3389/fgene.2022.844141,https://pubmed.ncbi.nlm.nih.gov/35480311/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB3,ENSG00000113205,Neither,30740043,Global Gene Knockout of Kcnip3 Enhances Pain Sensitivity and Exacerbates Negative Emotions in Rats.,2019,10.3389/fnmol.2019.00005,https://pubmed.ncbi.nlm.nih.gov/30740043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB3,ENSG00000113205,Neither,29537081,Exome sequencing reveals the genetic landscape and frequent inactivation of PCDHB3 in Chinese rectal cancers.,2018,10.1002/path.5073,https://pubmed.ncbi.nlm.nih.gov/29537081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB3,ENSG00000113205,Neither,26035870,Deletion of the App-Runx1 region in mice models human partial monosomy 21.,2015,10.1242/dmm.017814,https://pubmed.ncbi.nlm.nih.gov/26035870/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB3,ENSG00000113205,Neither,25032869,FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway.,2014,10.1038/cddis.2014.302,https://pubmed.ncbi.nlm.nih.gov/25032869/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB6,ENSG00000113211,Neither,42439350,A Transient Receptor Potential-related Gene Model for the Prognostic Assessment and Drug Sensitivity Prediction in Osteosarcoma.,2026,10.2174/0109298673510271260627113203,https://pubmed.ncbi.nlm.nih.gov/42439350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB6,ENSG00000113211,Neither,38417824,Influence of maternal folate depletion on Art3 DNA methylation in the murine adult brain; potential consequences for brain and neurocognitive health.,2024,10.1093/mutage/geae007,https://pubmed.ncbi.nlm.nih.gov/38417824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB6,ENSG00000113211,Neither,39765520,Comparative Whole-Genome Analysis of Production Traits and Genetic Structure in Baiyu and Chuanzhong Black Goats.,2024,10.3390/ani14243616,https://pubmed.ncbi.nlm.nih.gov/39765520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB6,ENSG00000113211,Neither,35480311,Association of DNA Methylation Patterns in 7 Novel Genes With Ischemic Stroke in the Northern Chinese Population.,2022,10.3389/fgene.2022.844141,https://pubmed.ncbi.nlm.nih.gov/35480311/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB6,ENSG00000113211,Neither,36230503,Molecular Classification of Hepatocellular Carcinoma Using Wnt-Hippo Signaling Pathway-Related Genes.,2022,10.3390/cancers14194580,https://pubmed.ncbi.nlm.nih.gov/36230503/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB6,ENSG00000113211,Neither,26035870,Deletion of the App-Runx1 region in mice models human partial monosomy 21.,2015,10.1242/dmm.017814,https://pubmed.ncbi.nlm.nih.gov/26035870/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB6,ENSG00000113211,Neither,30838020,Genome-Wide Association Study for Milk Protein Composition Traits in a Chinese Holstein Population Using a Single-Step Approach.,2019,10.3389/fgene.2019.00072,https://pubmed.ncbi.nlm.nih.gov/30838020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGA1,ENSG00000204956,Neither,42362890,Meta-analysis of DNA methylation aging signatures in 17 human tissues.,2026,10.1038/s43587-026-01164-5,https://pubmed.ncbi.nlm.nih.gov/42362890/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGA1,ENSG00000204956,Neither,40343304,DNA methylation in peripheral blood leukocytes in late onset Alzheimer's disease.,2025,10.1177/25424823251341176,https://pubmed.ncbi.nlm.nih.gov/40343304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGA1,ENSG00000204956,Neither,41260607,MYB Alterations in Angiocentric Gliomas.,2025,10.1111/neup.70036,https://pubmed.ncbi.nlm.nih.gov/41260607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGA1,ENSG00000204956,Neither,35574540,"Genetic Alteration Analysis of IDH1, IDH2, CDKN2A, MYB and MYBL1 in Pediatric Low-Grade Gliomas.",2022,10.3389/fsurg.2022.880048,https://pubmed.ncbi.nlm.nih.gov/35574540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGA1,ENSG00000204956,Neither,35968320,A novel 8-gene panel for prediction of early biochemical recurrence in patients with prostate cancer after radical prostatectomy.,2022,,https://pubmed.ncbi.nlm.nih.gov/35968320/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGA1,ENSG00000204956,Neither,34895303,Genome-wide methylation patterns in Marfan syndrome.,2021,10.1186/s13148-021-01204-4,https://pubmed.ncbi.nlm.nih.gov/34895303/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGA1,ENSG00000204956,Neither,34249129,"The Aqueous Extract of Eucommia Leaves Promotes Proliferation, Differentiation, and Mineralization of Osteoblast-Like MC3T3-E1 Cells.",2021,10.1155/2021/3641317,https://pubmed.ncbi.nlm.nih.gov/34249129/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGA1,ENSG00000204956,Neither,34704810,Identification and Prognostic Value Exploration of Cyclophosphamide (Cytoxan)-Centered Chemotherapy Response-Associated Genes in Breast Cancer.,2021,10.1089/dna.2021.0077,https://pubmed.ncbi.nlm.nih.gov/34704810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGA1,ENSG00000204956,Neither,32814111,"In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance.",2020,10.1053/j.gastro.2020.08.016,https://pubmed.ncbi.nlm.nih.gov/32814111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,42192102,PIWIL3-piRNA pathway controls rabbit oogenesis and embryogenesis via broad regulation of the transcriptome and proteome.,2026,10.1038/s41467-026-73503-4,https://pubmed.ncbi.nlm.nih.gov/42192102/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,41751607,The Association Between Estrogen Receptor-α and PIWIL3/piR-651/piR-823 Complex Regulates MI to MII Transposition in Normoresponder and Diminished Ovarian Reserve Cases.,2026,10.3390/genes17020223,https://pubmed.ncbi.nlm.nih.gov/41751607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,41267681,Investigation of the PIWI-interacting RNA expression differences in normoresponder and diminished ovarian reserve follicular fluid.,2025,10.1093/narmme/ugaf033,https://pubmed.ncbi.nlm.nih.gov/41267681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,40729068,"Decreased Expression Levels Of PIWIL2, PIWIL3 and PIWIL4 Are Associated with Poor Prognosis and Worse Survival in Bladder Cancer Patients.",2025,10.31557/apjcp.2025.26.7.2467,https://pubmed.ncbi.nlm.nih.gov/40729068/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,41813703,Integrated small and long RNA sequencing reveals piRNA mediated transposon repression during human oogenesis.,2026,10.1038/s41467-026-70296-4,https://pubmed.ncbi.nlm.nih.gov/41813703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,38043006,Elevated expression patterns of P-element Induced Wimpy Testis (PIWI) transcripts are potential candidate markers for Hepatocellular Carcinoma.,2024,10.3233/cbm-230134,https://pubmed.ncbi.nlm.nih.gov/38043006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,40744298,"Germline factors, TDRD and Piwi, colocalize with Vasa on the mitotic apparatus during the embryogenesis of the sea urchin.",2025,10.1016/j.ydbio.2025.07.016,https://pubmed.ncbi.nlm.nih.gov/40744298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,37644029,The non-redundant functions of PIWI family proteins in gametogenesis in golden hamsters.,2023,10.1038/s41467-023-40650-x,https://pubmed.ncbi.nlm.nih.gov/37644029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,36555927,A Novel PiRNA Enhances CA19-9 Sensitivity for Pancreatic Cancer Identification by Liquid Biopsy.,2022,10.3390/jcm11247310,https://pubmed.ncbi.nlm.nih.gov/36555927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,38532500,Divergent composition and transposon-silencing activity of small RNAs in mammalian oocytes.,2024,10.1186/s13059-024-03214-w,https://pubmed.ncbi.nlm.nih.gov/38532500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,32357464,The Clinical Significance of PIWIL3 and PIWIL4 Expression in Pancreatic Cancer.,2020,10.3390/jcm9051252,https://pubmed.ncbi.nlm.nih.gov/32357464/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,36293174,Identification and Characterization of Piwi-Interacting RNAs for Early Testicular Development in Yak.,2022,10.3390/ijms232012320,https://pubmed.ncbi.nlm.nih.gov/36293174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,34760405,Evolutionary history of the vertebrate Piwi gene family.,2021,10.7717/peerj.12451,https://pubmed.ncbi.nlm.nih.gov/34760405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,36853842,P-Element-Induced Wimpy Testis Proteins and P-Element-Induced Wimpy Testis-Interacting RNAs Expression in Ovarian Cancer Stem Cells.,2023,10.1089/gtmb.2022.0113,https://pubmed.ncbi.nlm.nih.gov/36853842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,32486081,PIWIL3 Forms a Complex with TDRKH in Mammalian Oocytes.,2020,10.3390/cells9061356,https://pubmed.ncbi.nlm.nih.gov/32486081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,35725394,A novel role for CFTR interaction with LH and FGF in azoospermia and epididymal maldevelopment caused by cryptorchidism.,2022,10.1186/s12610-022-00160-0,https://pubmed.ncbi.nlm.nih.gov/35725394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,35117181,The expression and the role of PIWI like RNA-mediated gene silencing 3 (PIWIL3) in lung cell line.,2020,10.21037/tcr.2019.12.91,https://pubmed.ncbi.nlm.nih.gov/35117181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,35170353,HIV-1 Tat and cocaine coexposure impacts piRNAs to affect astrocyte energy metabolism.,2022,10.2217/epi-2021-0252,https://pubmed.ncbi.nlm.nih.gov/35170353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,34489571,Production of functional oocytes requires maternally expressed PIWI genes and piRNAs in golden hamsters.,2021,10.1038/s41556-021-00745-3,https://pubmed.ncbi.nlm.nih.gov/34489571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,33590099,Hamster PIWI proteins bind to piRNAs with stage-specific size variations during oocyte maturation.,2021,10.1093/nar/gkab059,https://pubmed.ncbi.nlm.nih.gov/33590099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,34690620,Implementation of Vaccinomics and In-Silico Approaches to Construct Multimeric Based Vaccine Against Ovarian Cancer.,2021,10.1007/s10989-021-10294-w,https://pubmed.ncbi.nlm.nih.gov/34690620/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,34718612,Causal and Candidate Gene Variants in a Large Cohort of Women With Primary Ovarian Insufficiency.,2022,10.1210/clinem/dgab775,https://pubmed.ncbi.nlm.nih.gov/34718612/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,29470513,Offspring sex impacts DNA methylation and gene expression in placentae from women with diabetes during pregnancy.,2018,10.1371/journal.pone.0190698,https://pubmed.ncbi.nlm.nih.gov/29470513/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL3,ENSG00000184571,Neither,12906857,Identification of eight members of the Argonaute family in the human genome.,2003,10.1016/s0888-7543(03)00129-0,https://pubmed.ncbi.nlm.nih.gov/12906857/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLA2G2E,ENSG00000188784,Neither,42854579,Multi-omics analysis reveals that castration improves chicken meat flavor by altering lipid metabolic pathways.,2026,10.1016/j.foodchem.2026.151428,https://pubmed.ncbi.nlm.nih.gov/42854579/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLA2G2E,ENSG00000188784,Neither,42187237,Novel Potential Markers of Metabolic Dysfunction-Associated Steatohepatitis Prone to Hepatocellular Carcinoma.,2026,10.1155/cjgh/7390933,https://pubmed.ncbi.nlm.nih.gov/42187237/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLA2G2E,ENSG00000188784,Neither,38591879,Secreted phospholipase PLA2G2E contributes to regulation of T cell immune response against influenza virus infection.,2024,10.1128/jvi.00198-24,https://pubmed.ncbi.nlm.nih.gov/38591879/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLA2G2E,ENSG00000188784,Neither,37797578,Awakening neural survival mechanisms after stroke: Lipid metabolism in brain-autonomous repair.,2023,10.1016/j.neuron.2023.08.020,https://pubmed.ncbi.nlm.nih.gov/37797578/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLA2G2E,ENSG00000188784,Neither,37490917,PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke.,2023,10.1016/j.neuron.2023.06.024,https://pubmed.ncbi.nlm.nih.gov/37490917/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLA2G2E,ENSG00000188784,Neither,39186142,Inhibitory Effect and Mechanism of Epigallocatechin Gallate on the Differentiation of 3T3-L1 Preadipocytes.,2024,10.1007/s11130-024-01229-z,https://pubmed.ncbi.nlm.nih.gov/39186142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLA2G2E,ENSG00000188784,Neither,38128411,Proteomic signatures of eosinophilic and neutrophilic asthma from serum and sputum.,2024,10.1016/j.ebiom.2023.104936,https://pubmed.ncbi.nlm.nih.gov/38128411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLA2G2E,ENSG00000188784,Neither,24910243,The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.,2014,10.1016/j.cmet.2014.05.002,https://pubmed.ncbi.nlm.nih.gov/24910243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLA2G2E,ENSG00000188784,Neither,31743450,Therapeutic effects of Aconiti Lateralis Radix Praeparata combined with Zingiberis Rhizoma on doxorubicin-induced chronic heart failure in rats based on an integrated approach.,2020,10.1111/jphp.13191,https://pubmed.ncbi.nlm.nih.gov/31743450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLA2G2E,ENSG00000188784,Neither,33708236,Selective Sweeps Uncovering the Genetic Basis of Horn and Adaptability Traits on Fine-Wool Sheep in China.,2021,10.3389/fgene.2021.604235,https://pubmed.ncbi.nlm.nih.gov/33708236/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLA2G2E,ENSG00000188784,Neither,18801741,"Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis.",2008,10.1074/jbc.m804628200,https://pubmed.ncbi.nlm.nih.gov/18801741/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLA2G2E,ENSG00000188784,Neither,10681567,"Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s.",2000,10.1074/jbc.275.8.5785,https://pubmed.ncbi.nlm.nih.gov/10681567/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLSCR2,ENSG00000163746,Neither,42353386,Multi-Omics Analysis Reveals New Insights into Yak Lung Under High-Altitude Adaptation.,2026,10.3390/ani16121775,https://pubmed.ncbi.nlm.nih.gov/42353386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLSCR2,ENSG00000163746,Neither,39470061,Epigenetic Study of Cohort of Monozygotic Twins With Hypertrophic Cardiomyopathy Due to MYBPC3 (Cardiac Myosin-Binding Protein C).,2024,10.1161/jaha.124.035777,https://pubmed.ncbi.nlm.nih.gov/39470061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLSCR2,ENSG00000163746,Neither,30158934,STAT3 Cooperates With Phospholipid Scramblase 2 to Suppress Type I Interferon Response.,2018,10.3389/fimmu.2018.01886,https://pubmed.ncbi.nlm.nih.gov/30158934/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLSCR2,ENSG00000163746,Neither,30593902,Two phospholipid scramblase 1-related proteins (PLSCR1like-a & -b) from Liza haematocheila: Molecular and transcriptional features and expression analysis after immune stimulation.,2019,10.1016/j.fsi.2018.12.044,https://pubmed.ncbi.nlm.nih.gov/30593902/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLSCR2,ENSG00000163746,Neither,22740871,Protein expression pattern in response to ionizing radiation in MCF-7 human breast cancer cells.,2012,10.3892/ol.2011.444,https://pubmed.ncbi.nlm.nih.gov/22740871/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLSCR2,ENSG00000163746,Neither,16979355,Phospholipid scramblase isoform expression in pregnant rat uterus.,2006,10.1016/j.jsgi.2006.06.002,https://pubmed.ncbi.nlm.nih.gov/16979355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLSCR2,ENSG00000163746,Neither,21344158,Effect of PP2A on p34SEI-1 expression in response to ionizing radiation in MCF-7 human breast cancer cells.,2011,10.3892/ijo.2011.950,https://pubmed.ncbi.nlm.nih.gov/21344158/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLSCR2,ENSG00000163746,Neither,17506908,Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate.,2007,10.1186/1471-2407-7-84,https://pubmed.ncbi.nlm.nih.gov/17506908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLSCR2,ENSG00000163746,Neither,10930526,Identification of three new members of the phospholipid scramblase gene family.,2000,10.1016/s0005-2736(00)00236-4,https://pubmed.ncbi.nlm.nih.gov/10930526/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PMIS2,ENSG00000283758,Neither,38612464,SMA20/PMIS2 Is a Rapidly Evolving Sperm Membrane Alloantigen with Possible Species-Divergent Function in Fertilization.,2024,10.3390/ijms25073652,https://pubmed.ncbi.nlm.nih.gov/38612464/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PMIS2,ENSG00000283758,Neither,22621904,Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa.,2012,10.1091/mbc.e11-12-1025,https://pubmed.ncbi.nlm.nih.gov/22621904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNMA6E,ENSG00000214897,Neither,30130116,Deciphering the Dark Proteome: Use of the Testis and Characterization of Two Dark Proteins.,2018,10.1021/acs.jproteome.8b00387,https://pubmed.ncbi.nlm.nih.gov/30130116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POM121L2,ENSG00000158553,Neither,37628841,Methylation Profile of Small Breast Cancer Tumors Evaluated by Modified MS-HRM.,2023,10.3390/ijms241612660,https://pubmed.ncbi.nlm.nih.gov/37628841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POM121L2,ENSG00000158553,Neither,36515925,"Identification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans.",2023,10.1001/jamapsychiatry.2022.3896,https://pubmed.ncbi.nlm.nih.gov/36515925/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POM121L2,ENSG00000158553,Neither,33113958,DNA Methylation and Breast Cancer Risk: An Epigenome-Wide Study of Normal Breast Tissue and Blood.,2020,10.3390/cancers12113088,https://pubmed.ncbi.nlm.nih.gov/33113958/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POM121L2,ENSG00000158553,Neither,31953506,Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients.,2020,10.1038/s41598-019-57358-y,https://pubmed.ncbi.nlm.nih.gov/31953506/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POM121L2,ENSG00000158553,Neither,23526225,Epigenetic alterations by DNA methylation in house dust mite-induced airway hyperresponsiveness.,2013,10.1165/rcmb.2012-0403oc,https://pubmed.ncbi.nlm.nih.gov/23526225/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POM121L2,ENSG00000158553,Neither,23894747,A comprehensive family-based replication study of schizophrenia genes.,2013,10.1001/jamapsychiatry.2013.288,https://pubmed.ncbi.nlm.nih.gov/23894747/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEA,ENSG00000188877,Neither,41957852,Genome-wide copy-number analysis improves detection of pathogenic AZFc and autosomal variants in idiopathic non-obstructive azoospermia.,2026,10.1186/s13039-026-00758-3,https://pubmed.ncbi.nlm.nih.gov/41957852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEA,ENSG00000188877,Neither,37545223,TRB CDR3-cancer testis antigen chemical complementarity scoring for identifying productive immune responses in renal cell carcinoma.,2023,10.3233/cbm-230047,https://pubmed.ncbi.nlm.nih.gov/37545223/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEA,ENSG00000188877,Neither,29547645,"Recurrent, low-frequency coding variants contributing to colorectal cancer in the Swedish population.",2018,10.1371/journal.pone.0193547,https://pubmed.ncbi.nlm.nih.gov/29547645/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEA,ENSG00000188877,Neither,29698858,Cell membrane-bound CD200 signals both via an extracellular domain and following nuclear translocation of a cytoplasmic fragment.,2018,10.1016/j.leukres.2018.04.007,https://pubmed.ncbi.nlm.nih.gov/29698858/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEB,ENSG00000233917,Neither,32636717,The plasma peptides of sepsis.,2020,10.1186/s12014-020-09288-5,https://pubmed.ncbi.nlm.nih.gov/32636717/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEB,ENSG00000233917,Neither,28420514,Detection of mosaic 15q11.1-q11.2 deletion encompassing NBEAP1 and POTEB in a fetus with diffuse lymphangiomatosis.,2017,10.1016/j.tjog.2017.01.003,https://pubmed.ncbi.nlm.nih.gov/28420514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEB3,ENSG00000278522,Neither,41096749,Rare-Variant Genome-Wide Association and Polygenic Score Assessment of Vitamin D Status in a Middle Eastern Population.,2025,10.3390/ijms26199481,https://pubmed.ncbi.nlm.nih.gov/41096749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEC,ENSG00000183206,Neither,40588653,PoTeC: A German naturalistic eye-tracking-while-reading corpus.,2025,10.3758/s13428-024-02536-8,https://pubmed.ncbi.nlm.nih.gov/40588653/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEC,ENSG00000183206,Neither,41095994,"POTEC (Platelet Count, Oxygen Saturation, Time of CPR, Elective Surgery, and Initial ETCO&lt;sub&gt;2&lt;/sub&gt;) Score for Predicting 24-h Survival After Perioperative Cardiopulmonary Resuscitation: Development and Validation.",2025,10.3390/jcm14196915,https://pubmed.ncbi.nlm.nih.gov/41095994/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEC,ENSG00000183206,Neither,31218106,Loss of ZNF587B and SULF1 contributed to cisplatin resistance in ovarian cancer cell lines based on Genome-scale CRISPR/Cas9 screening.,2019,,https://pubmed.ncbi.nlm.nih.gov/31218106/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEC,ENSG00000183206,Neither,12475935,"POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.",2002,10.1073/pnas.262655399,https://pubmed.ncbi.nlm.nih.gov/12475935/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,41655991,Silencing of E6/E7 proteins of HPV-16 in the CaCx cell line upregulate the expression of POTE-Paralogs.,2026,,https://pubmed.ncbi.nlm.nih.gov/41655991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,42789680,A bacterial pangenome association study identifies a role for polyamine metabolism and alkaline tolerance in middle ear infections.,2026,10.1371/journal.ppat.1014649,https://pubmed.ncbi.nlm.nih.gov/42789680/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,42289469,POTEF upregulation drives hepatocellular carcinoma progression via oncogenic signaling and immune modulation.,2026,10.1038/s41598-026-56207-z,https://pubmed.ncbi.nlm.nih.gov/42289469/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,41235918,PstSCAB and SapBCDF are putrescine exporters in &lt;i&gt;Proteus mirabilis&lt;/i&gt;.,2026,10.1128/spectrum.04306-23,https://pubmed.ncbi.nlm.nih.gov/41235918/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,36132183,"BESFA: bioinformatics based evolutionary, structural & functional analysis of prostrate, Placenta, Ovary, Testis, and Embryo (POTE) paralogs.",2022,10.1016/j.heliyon.2022.e10476,https://pubmed.ncbi.nlm.nih.gov/36132183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,42155959,Salivary protein profile of PLHIV on long-term antiretroviral therapy suggests latent reservoir and immune exhaustion.,2026,10.1016/j.archoralbio.2026.106624,https://pubmed.ncbi.nlm.nih.gov/42155959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,38137511,Genomic Landscape Comparison of Cardiac versus Extra-Cardiac Angiosarcomas.,2023,10.3390/biomedicines11123290,https://pubmed.ncbi.nlm.nih.gov/38137511/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,39534429,MARK1 suppress malignant progression of hepatocellular carcinoma and improves sorafenib resistance through negatively regulating POTEE.,2024,10.1515/med-2024-1060,https://pubmed.ncbi.nlm.nih.gov/39534429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,41164477,Study of Serum Creatinine Level in Essential Hypertension: An Observational Study.,2025,10.4103/jpbs.jpbs_1116_25,https://pubmed.ncbi.nlm.nih.gov/41164477/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,38098337,POTEE promotes breast cancer cell malignancy by inducing invadopodia formation through the activation of SUMOylated Rac1.,2024,10.1002/1878-0261.13568,https://pubmed.ncbi.nlm.nih.gov/38098337/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,40834976,LncRNA LINC00667 inhibits breast cancer progression by regulating POTEE to suppress mitochondrial oxidative phosphorylation.,2025,10.1016/j.cellsig.2025.112074,https://pubmed.ncbi.nlm.nih.gov/40834976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,36866106,Whole genome sequencing of Malaysian colorectal cancer patients reveals specific druggable somatic mutations.,2022,10.3389/fmolb.2022.997747,https://pubmed.ncbi.nlm.nih.gov/36866106/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,32085667,Evolutionary Dynamics of the POTE Gene Family in Human and Nonhuman Primates.,2020,10.3390/genes11020213,https://pubmed.ncbi.nlm.nih.gov/32085667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,30459449,Expression of the POTE gene family in human ovarian cancer.,2018,10.1038/s41598-018-35567-1,https://pubmed.ncbi.nlm.nih.gov/30459449/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,40961347,Use of genome-scale metabolic reconstructions of avian pathogenic &lt;i&gt;Escherichia coli&lt;/i&gt; (APEC) phylogroups for the identification of lineage-specific metabolic pathways.,2025,10.1099/mgen.0.001490,https://pubmed.ncbi.nlm.nih.gov/40961347/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,30764732,Epigenetic activation of POTE genes in ovarian cancer.,2019,10.1080/15592294.2019.1581590,https://pubmed.ncbi.nlm.nih.gov/30764732/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,40181292,Genomic and Transcriptomic Adaptation to Chlorhexidine in &lt;i&gt;Streptococcus&lt;/i&gt; spp.,2025,10.1177/00220345251320912,https://pubmed.ncbi.nlm.nih.gov/40181292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,34285194,Primate-specific POTE-actin gene could play a role in human folliculogenesis by controlling the proliferation of granulosa cells.,2021,10.1038/s41420-021-00566-1,https://pubmed.ncbi.nlm.nih.gov/34285194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,39337655,Augmented Global Protein Acetylation Diminishes Cell Growth and Migration of Cholangiocarcinoma Cells.,2024,10.3390/ijms251810170,https://pubmed.ncbi.nlm.nih.gov/39337655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,29566278,Down-regulation of POTEG predicts poor prognosis in esophageal squamous cell carcinoma patients.,2018,10.1002/mc.22809,https://pubmed.ncbi.nlm.nih.gov/29566278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,39933095,"Anti-Diversity, Equity, and Inclusion Legislation: Potential Impacts on Oncology Nursing Workforce Diversity and Patient Health Outcomes.",2025,10.1188/25.cjon.100-103,https://pubmed.ncbi.nlm.nih.gov/39933095/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,41136165,Redefining LuxI as a metabolic gatekeeper in bacterial spoilage of refrigerated turbot by Hafnia alvei H4.,2026,10.1016/j.fm.2025.104949,https://pubmed.ncbi.nlm.nih.gov/41136165/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,37318657,POTEE mutation as a potential predictive biomarker for immune checkpoint inhibitors in lung adenocarcinoma.,2023,10.1007/s10637-023-01375-2,https://pubmed.ncbi.nlm.nih.gov/37318657/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,23750208,Identification and enhancement of HLA-A2.1-restricted CTL epitopes in a new human cancer antigen-POTE.,2013,10.1371/journal.pone.0064365,https://pubmed.ncbi.nlm.nih.gov/23750208/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,33003195,Ornithine Decarboxylation System of Shewanella baltica Regulates Putrescine Production and Acid Resistance.,2021,10.4315/jfp-20-227,https://pubmed.ncbi.nlm.nih.gov/33003195/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,35308356,Production of Putrescine and Cadaverine by Paucilactobacillus wasatchensis.,2022,10.3389/fmicb.2022.842403,https://pubmed.ncbi.nlm.nih.gov/35308356/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,36660601,Isolation of the high polyamine-producing bacterium Staphylococcus epidermidis FB146 from fermented foods and identification of polyamine-related genes.,2023,10.12938/bmfh.2022-011,https://pubmed.ncbi.nlm.nih.gov/36660601/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,29507315,Lactobacillus rossiae strain isolated from sourdough produces putrescine from arginine.,2018,10.1038/s41598-018-22309-6,https://pubmed.ncbi.nlm.nih.gov/29507315/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,29746385,Strength and Sprint Time Changes in Response to Repeated Shuttles Between the Wickets During Batting in Cricket.,2019,10.1519/jsc.0000000000002585,https://pubmed.ncbi.nlm.nih.gov/29746385/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,25063650,Polyamine transporters and polyamines increase furfural tolerance during xylose fermentation with ethanologenic Escherichia coli strain LY180.,2014,10.1128/aem.01913-14,https://pubmed.ncbi.nlm.nih.gov/25063650/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,33132564,Increase in Cadaver Organ Donation Rate at a Tertiary Care Hospital: 23 Years of Experience.,2020,10.5005/jp-journals-10071-23578,https://pubmed.ncbi.nlm.nih.gov/33132564/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,16397215,POTE paralogs are induced and differentially expressed in many cancers.,2006,10.1158/0008-5472.can-05-3014,https://pubmed.ncbi.nlm.nih.gov/16397215/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTED,ENSG00000166351,Neither,12475935,"POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.",2002,10.1073/pnas.262655399,https://pubmed.ncbi.nlm.nih.gov/12475935/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEF,ENSG00000196604,Neither,42289469,POTEF upregulation drives hepatocellular carcinoma progression via oncogenic signaling and immune modulation.,2026,10.1038/s41598-026-56207-z,https://pubmed.ncbi.nlm.nih.gov/42289469/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEF,ENSG00000196604,Neither,41655991,Silencing of E6/E7 proteins of HPV-16 in the CaCx cell line upregulate the expression of POTE-Paralogs.,2026,,https://pubmed.ncbi.nlm.nih.gov/41655991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEF,ENSG00000196604,Neither,39825964,Natural products and long non-coding RNAs in prostate cancer: insights into etiology and treatment resistance.,2025,10.1007/s00210-024-03736-x,https://pubmed.ncbi.nlm.nih.gov/39825964/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEF,ENSG00000196604,Neither,36132183,"BESFA: bioinformatics based evolutionary, structural & functional analysis of prostrate, Placenta, Ovary, Testis, and Embryo (POTE) paralogs.",2022,10.1016/j.heliyon.2022.e10476,https://pubmed.ncbi.nlm.nih.gov/36132183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEF,ENSG00000196604,Neither,34285194,Primate-specific POTE-actin gene could play a role in human folliculogenesis by controlling the proliferation of granulosa cells.,2021,10.1038/s41420-021-00566-1,https://pubmed.ncbi.nlm.nih.gov/34285194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEF,ENSG00000196604,Neither,38424541,Deciphering the omicron variant: integrated omics analysis reveals critical biomarkers and pathophysiological pathways.,2024,10.1186/s12967-024-05022-z,https://pubmed.ncbi.nlm.nih.gov/38424541/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEF,ENSG00000196604,Neither,33107155,Comprehensive role of prostate-specific antigen identified with proteomic analysis in prostate cancer.,2020,10.1111/jcmm.15634,https://pubmed.ncbi.nlm.nih.gov/33107155/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEF,ENSG00000196604,Neither,34966852,"ACTB and GAPDH appear at multiple SDS-PAGE positions, thus not suitable as reference genes for determining protein loading in techniques like Western blotting.",2021,10.1515/biol-2021-0130,https://pubmed.ncbi.nlm.nih.gov/34966852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEF,ENSG00000196604,Neither,28032932,Androgen-induced lncRNA POTEF-AS1 regulates apoptosis-related pathway to facilitate cell survival in prostate cancer cells.,2017,10.1111/cas.13151,https://pubmed.ncbi.nlm.nih.gov/28032932/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEF,ENSG00000196604,Neither,31124977,KEGG-expressed genes and pathways in intervertebral disc degeneration: Protocol for a systematic review and data mining.,2019,10.1097/md.0000000000015796,https://pubmed.ncbi.nlm.nih.gov/31124977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEF,ENSG00000196604,Neither,32537633,Regulation of Actg1 and Gsta2 is possible mechanism by which capsaicin alleviates apoptosis in cell model of 6-OHDA-induced Parkinson's disease.,2020,10.1042/bsr20191796,https://pubmed.ncbi.nlm.nih.gov/32537633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEF,ENSG00000196604,Neither,30420269,Identification of MΦ specific POTEE expression: Its role in mTORC2 activation via protein-protein interaction in TAMs.,2019,10.1016/j.cellimm.2018.10.010,https://pubmed.ncbi.nlm.nih.gov/30420269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEF,ENSG00000196604,Neither,25884948,Lower PRDM2 expression is associated with dopamine-agonist resistance and tumor recurrence in prolactinomas.,2015,10.1186/s12885-015-1267-0,https://pubmed.ncbi.nlm.nih.gov/25884948/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEF,ENSG00000196604,Neither,25848723,Lectin RCA-I specifically binds to metastasis-associated cell surface glycans in triple-negative breast cancer.,2015,10.1186/s13058-015-0544-9,https://pubmed.ncbi.nlm.nih.gov/25848723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEF,ENSG00000196604,Neither,26474971,"A genome-wide approach to link genotype to clinical outcome by utilizing next generation sequencing and gene chip data of 6,697 breast cancer patients.",2015,10.1186/s13073-015-0228-1,https://pubmed.ncbi.nlm.nih.gov/26474971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEF,ENSG00000196604,Neither,24096332,Transcriptional activation of heat shock protein 90 mediated via a proximal promoter region as trigger of caspofungin resistance in Aspergillus fumigatus.,2014,10.1093/infdis/jit530,https://pubmed.ncbi.nlm.nih.gov/24096332/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEF,ENSG00000196604,Neither,17101985,Evolution and expression of chimeric POTE-actin genes in the human genome.,2006,10.1073/pnas.0608344103,https://pubmed.ncbi.nlm.nih.gov/17101985/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEH,ENSG00000198062,Neither,38137511,Genomic Landscape Comparison of Cardiac versus Extra-Cardiac Angiosarcomas.,2023,10.3390/biomedicines11123290,https://pubmed.ncbi.nlm.nih.gov/38137511/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEH,ENSG00000198062,Neither,36611251,Genomic Profiling Reveals the Variant Landscape of Sporadic Parathyroid Adenomas in Chinese Population.,2023,10.1210/clinem/dgad002,https://pubmed.ncbi.nlm.nih.gov/36611251/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEH,ENSG00000198062,Neither,34938660,"A Three lncRNA Set: AC009975.1, POTEH-AS1 and AL390243.1 as Nodal Efficacy Biomarker of Neoadjuvant Therapy for HER-2 Positive Breast Cancer.",2021,10.3389/fonc.2021.779140,https://pubmed.ncbi.nlm.nih.gov/34938660/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEH,ENSG00000198062,Neither,21439273,"POTEH hypomethylation, a new epigenetic biomarker for glioma prognosis.",2011,10.1016/j.brainres.2011.03.042,https://pubmed.ncbi.nlm.nih.gov/21439273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEI,ENSG00000196834,Neither,40153687,Comprehensive Molecular and Genomic Analysis of NCI-MATCH Subprotocol Y: Capivasertib in Patients With an &lt;i&gt;AKT1 E17K&lt;/i&gt;-Mutated Tumor.,2025,10.1200/po-24-00614,https://pubmed.ncbi.nlm.nih.gov/40153687/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEI,ENSG00000196834,Neither,35582841,Primary pseudomyogenic haemangioendothelioma of the testis with a novel POTEI::FOSB gene fusion.,2022,10.1111/his.14697,https://pubmed.ncbi.nlm.nih.gov/35582841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEI,ENSG00000196834,Neither,36132183,"BESFA: bioinformatics based evolutionary, structural & functional analysis of prostrate, Placenta, Ovary, Testis, and Embryo (POTE) paralogs.",2022,10.1016/j.heliyon.2022.e10476,https://pubmed.ncbi.nlm.nih.gov/36132183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEI,ENSG00000196834,Neither,38489594,Distinguish response of low-dose radiation with different dose-rate on gene expression of human coronary artery endothelial cells: a bioinformatic study based on transcriptomic sequencing.,2024,10.1080/09553002.2024.2324470,https://pubmed.ncbi.nlm.nih.gov/38489594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEI,ENSG00000196834,Neither,35440622,Exome sequencing of families from Ghana reveals known and candidate hearing impairment genes.,2022,10.1038/s42003-022-03326-8,https://pubmed.ncbi.nlm.nih.gov/35440622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEI,ENSG00000196834,Neither,34966852,"ACTB and GAPDH appear at multiple SDS-PAGE positions, thus not suitable as reference genes for determining protein loading in techniques like Western blotting.",2021,10.1515/biol-2021-0130,https://pubmed.ncbi.nlm.nih.gov/34966852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEI,ENSG00000196834,Neither,10349321,[Analysis of the activity of neurologic intensive care units].,1999,,https://pubmed.ncbi.nlm.nih.gov/10349321/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,41836594,"Methylation and Expression Analysis of POU4F2, HOXA9, RBM46, and TSGA10 Genes in Bladder Cancer Using Methyl-Sensitive Restriction Enzyme PCR (MSRE-PCR).",2026,10.2147/cmar.s557943,https://pubmed.ncbi.nlm.nih.gov/41836594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,41029537,The diagnostic performance of a noninvasive urine-based methylation biomarkers Vimentin/POU4F2 to detect bladder carcinoma.,2025,10.1186/s12885-025-14795-5,https://pubmed.ncbi.nlm.nih.gov/41029537/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,41028711,Genetic tuning of retinal ganglion cell subtype identity to drive visual behavior.,2025,10.1038/s41467-025-63675-w,https://pubmed.ncbi.nlm.nih.gov/41028711/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,41106566,Jiedu Sangen Decoction inhibits Epithelial-mesenchymal transition of colon adenocarcinoma via POU4F2/Hedgehog pathway.,2026,10.1016/j.jep.2025.120752,https://pubmed.ncbi.nlm.nih.gov/41106566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,39946314,POU4F2 overexpression promotes the genesis of retinal ganglion cell-like projection neurons from late progenitors.,2025,10.1242/dev.204297,https://pubmed.ncbi.nlm.nih.gov/39946314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,42528139,Lineage-tailored vesicles from human retinal ganglion-like cells drive metabolic homeostasis and bioenergetic recovery in glaucoma.,2026,10.1016/j.ymthe.2026.07.051,https://pubmed.ncbi.nlm.nih.gov/42528139/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,41137390,Development of an AAV-based gene therapy for the ocular phenotype of Friedreich's ataxia.,2026,10.1016/j.ymthe.2025.10.048,https://pubmed.ncbi.nlm.nih.gov/41137390/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,42774032,Reporter-guided photoreceptor differentiation in 2D culture using PGP1-hIPSCs: A comparable alternative to 3D organoid systems?,2026,10.63500/mv_v32_232,https://pubmed.ncbi.nlm.nih.gov/42774032/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,41775853,Müller glia derived EVs promote neurite recovery of an enriched population of retinal ganglion like cells derived from hESC retinal organoids after damage.,2026,10.1038/s41598-026-42089-8,https://pubmed.ncbi.nlm.nih.gov/41775853/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,37983249,Brn3b regulates the formation of fear-related midbrain circuits and defensive responses to visual threat.,2023,10.1371/journal.pbio.3002386,https://pubmed.ncbi.nlm.nih.gov/37983249/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,39684658,Integration and Differentiation of Transplanted Human iPSC-Derived Retinal Ganglion Cell Precursors in Murine Retinas.,2024,10.3390/ijms252312947,https://pubmed.ncbi.nlm.nih.gov/39684658/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,39264015,Environmental Light Controls the Daily Organization of Breathing by Activating Brn3b-expressing Intrinsically Photosensitive Retinal Ganglion Cells in Mice.,2024,10.1177/07487304241276888,https://pubmed.ncbi.nlm.nih.gov/39264015/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,41420251,Novel DNA methylation biomarkers in urine for non-invasive diagnosis of bladder urothelial carcinoma.,2025,10.1186/s13148-025-01964-3,https://pubmed.ncbi.nlm.nih.gov/41420251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,40409357,The effects of pigment epithelium-derived factor and associated peptides on the differentiation of retinal ganglion cells from human-induced pluripotent stem cells.,2025,10.1016/j.exer.2025.110440,https://pubmed.ncbi.nlm.nih.gov/40409357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,38007517,Vascular dysfunction caused by loss of Brn-3b/POU4F2 transcription factor in aortic vascular smooth muscle cells is linked to deregulation of calcium signalling pathways.,2023,10.1038/s41419-023-06306-w,https://pubmed.ncbi.nlm.nih.gov/38007517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,37165305,The landscape of the long non-coding RNAs in developing mouse retinas.,2023,10.1186/s12864-023-09354-w,https://pubmed.ncbi.nlm.nih.gov/37165305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,38992573,Intervention of epithelial mesenchymal transition against colon cancer cell growth and metastasis based on SOX21/POU4F2/Hedgehog signaling axis.,2024,10.1016/j.lfs.2024.122905,https://pubmed.ncbi.nlm.nih.gov/38992573/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,31197108,A Novel Reporter Mouse Uncovers Endogenous Brn3b Expression.,2019,10.3390/ijms20122903,https://pubmed.ncbi.nlm.nih.gov/31197108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,40058721,Regeneration of retinal ganglion cell-like cells and reconstruction of visual neural circuits in mice with glaucoma.,2025,10.1016/j.exer.2025.110327,https://pubmed.ncbi.nlm.nih.gov/40058721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,34869356,CRISPR Generated SIX6 and POU4F2 Reporters Allow Identification of Brain and Optic Transcriptional Differences in Human PSC-Derived Organoids.,2021,10.3389/fcell.2021.764725,https://pubmed.ncbi.nlm.nih.gov/34869356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,32997561,Retinal ganglion cell defects cause decision shifts in visually evoked defense responses.,2020,10.1152/jn.00474.2019,https://pubmed.ncbi.nlm.nih.gov/32997561/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,36455722,Embryo developmental toxicity in marine medaka (Oryzias melastigma) due to parental and embryonic 17α-ethinylestradiol exposure.,2023,10.1016/j.scitotenv.2022.160594,https://pubmed.ncbi.nlm.nih.gov/36455722/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,35473892,Differences Between Sorafenib and Lenvatinib Treatment from Genetic and Clinical Perspectives for Patients with Hepatocellular Carcinoma.,2022,10.12659/msm.934936,https://pubmed.ncbi.nlm.nih.gov/35473892/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,37540379,The efficient induction of human retinal ganglion-like cells provides a platform for studying optic neuropathies.,2023,10.1007/s00018-023-04890-w,https://pubmed.ncbi.nlm.nih.gov/37540379/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,35396331,The Retinal Basis of Light Aversion in Neonatal Mice.,2022,10.1523/jneurosci.0151-22.2022,https://pubmed.ncbi.nlm.nih.gov/35396331/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,34671605,In vivo Regeneration of Ganglion Cells for Vision Restoration in Mammalian Retinas.,2021,10.3389/fcell.2021.755544,https://pubmed.ncbi.nlm.nih.gov/34671605/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,32088091,Allium cepa exerts neuroprotective effect on retinal ganglion cells of pterygopalatine artery (PPA) ligated mice.,2020,10.1016/j.jaim.2019.08.002,https://pubmed.ncbi.nlm.nih.gov/32088091/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,29437159,Single cell RNA sequencing of stem cell-derived retinal ganglion cells.,2018,10.1038/sdata.2018.13,https://pubmed.ncbi.nlm.nih.gov/29437159/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,30613365,POU4F2/Brn-3b transcription factor is associated with survival and drug resistance in human ovarian cancer cells.,2018,10.18632/oncotarget.26371,https://pubmed.ncbi.nlm.nih.gov/30613365/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,27293372,Stage-specific differentiation of iPSCs toward retinal ganglion cell lineage.,2016,,https://pubmed.ncbi.nlm.nih.gov/27293372/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,25666360,Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells.,2015,10.1038/srep08344,https://pubmed.ncbi.nlm.nih.gov/25666360/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,24369052,Systems biology approach to stage-wise characterization of epigenetic genes in lung adenocarcinoma.,2013,10.1186/1752-0509-7-141,https://pubmed.ncbi.nlm.nih.gov/24369052/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,24367375,Aberrantly methylated genes in human papillary thyroid cancer and their association with BRAF/RAS mutation.,2013,10.3389/fgene.2013.00271,https://pubmed.ncbi.nlm.nih.gov/24367375/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,24493857,Chemically induced specification of retinal ganglion cells from human embryonic and induced pluripotent stem cells.,2014,10.5966/sctm.2013-0147,https://pubmed.ncbi.nlm.nih.gov/24493857/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,18693149,The role of streptococcal hypersensitivity in the pathogenesis of Behçet's Disease.,2008,10.1684/ejd.2008.0484,https://pubmed.ncbi.nlm.nih.gov/18693149/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F2,ENSG00000151615,Neither,7691107,Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells.,1993,10.1016/0896-6273(93)90079-7,https://pubmed.ncbi.nlm.nih.gov/7691107/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PP2D1,ENSG00000183977,Neither,39975719,Gene expression profiles in respiratory settings in rats under extracorporeal membrane oxygenation.,2025,10.21037/jtd-24-1661,https://pubmed.ncbi.nlm.nih.gov/39975719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PP2D1,ENSG00000183977,Neither,32814578,Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets.,2020,10.1186/s12915-020-00826-z,https://pubmed.ncbi.nlm.nih.gov/32814578/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PP2D1,ENSG00000183977,Neither,32650009,"Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors.",2020,10.1016/j.pharmthera.2020.107622,https://pubmed.ncbi.nlm.nih.gov/32650009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,41428164,FK506 binding protein 12.6-mediated inhibition of sperm-specific calcineurin is essential for FK506-induced male infertility by disturbing the homeostasis of calcium and mitochondria.,2025,10.1186/s43556-025-00391-3,https://pubmed.ncbi.nlm.nih.gov/41428164/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,42002767,"Genome-wide mapping of stress-responsive lncRNA, uc.104, reveals the chromatin-mediated regulation of stress and plasticity-related genes in the hippocampus of chronic restraint rats.",2026,10.1186/s13041-026-01304-3,https://pubmed.ncbi.nlm.nih.gov/42002767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,40867601,The Role of miRNA167 in Skin Improvement: Insight from Extracellular Vesicles Derived from Rock Samphire (&lt;i&gt;Crithmum maritimum&lt;/i&gt;).,2025,10.3390/biom15081157,https://pubmed.ncbi.nlm.nih.gov/40867601/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,31900494,Dependence of sperm structural and functional integrity on testicular calcineurin isoform PPP3R2 expression.,2020,10.1093/jmcb/mjz115,https://pubmed.ncbi.nlm.nih.gov/31900494/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,34446558,SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.,2021,10.1073/pnas.2106673118,https://pubmed.ncbi.nlm.nih.gov/34446558/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,39655393,Genomic Effects of Biomechanical Loading in Adolescent Human Growth Plate Cartilage: A Pilot Study.,2026,10.1177/19476035241302954,https://pubmed.ncbi.nlm.nih.gov/39655393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,39845655,Relationship between Internet use and offline leisure activities among Chinese older adult people: a moderated mediation model.,2024,10.3389/fpubh.2024.1458413,https://pubmed.ncbi.nlm.nih.gov/39845655/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,37213430,"""What is language for us?"": Community-based Anishinaabemowin language planning using TEK-nology.",2023,10.1007/s10993-023-09656-5,https://pubmed.ncbi.nlm.nih.gov/37213430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,37998420,Associations between Combined Psychological and Lifestyle Factors with Pain Intensity and/or Disability in Patients with Chronic Low Back Pain: A Cross-Sectional Study.,2023,10.3390/healthcare11222928,https://pubmed.ncbi.nlm.nih.gov/37998420/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,37841933,"Isolation and characterization of ZK002, a novel dual function snake venom protein from Deinagkistrodon acutus with anti-angiogenic and anti-inflammatory properties.",2023,10.3389/fphar.2023.1227962,https://pubmed.ncbi.nlm.nih.gov/37841933/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,34955022,Profiling Cystathionine β/γ-Lyase in Complex Biosamples Using Novel Activatable Fluorogens.,2022,10.1021/acs.analchem.1c04393,https://pubmed.ncbi.nlm.nih.gov/34955022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,26429887,Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive.,2015,10.1126/science.aad0836,https://pubmed.ncbi.nlm.nih.gov/26429887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,28383548,miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2.,2017,10.1038/cddis.2017.146,https://pubmed.ncbi.nlm.nih.gov/28383548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,15865209,Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis.,2005,10.1007/s11033-004-4250-4,https://pubmed.ncbi.nlm.nih.gov/15865209/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,27831554,The control of male fertility by spermatid-specific factors: searching for contraceptive targets from spermatozoon's head to tail.,2016,10.1038/cddis.2016.344,https://pubmed.ncbi.nlm.nih.gov/27831554/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,27511815,EAN guidelines on central neurostimulation therapy in chronic pain conditions.,2016,10.1111/ene.13103,https://pubmed.ncbi.nlm.nih.gov/27511815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,30911339,Optimizing the Management and Outcomes of Failed Back Surgery Syndrome: A Consensus Statement on Definition and Outlines for Patient Assessment.,2019,10.1155/2019/3126464,https://pubmed.ncbi.nlm.nih.gov/30911339/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,25201034,Gene profiling of human VEGF signaling pathways in human endothelial and retinal pigment epithelial cells after anti VEGF treatment.,2014,10.1186/1756-0500-7-617,https://pubmed.ncbi.nlm.nih.gov/25201034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,20107831,Are calcineurin genes associated with endurance phenotype traits?,2010,10.1007/s00421-010-1361-6,https://pubmed.ncbi.nlm.nih.gov/20107831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,17684544,Systematic association mapping identifies NELL1 as a novel IBD disease gene.,2007,10.1371/journal.pone.0000691,https://pubmed.ncbi.nlm.nih.gov/17684544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,32769414,High-frequency 10 kHz Spinal Cord Stimulation for Chronic Back and Leg Pain: Cost-consequence and Cost-effectiveness Analyses.,2020,10.1097/ajp.0000000000000866,https://pubmed.ncbi.nlm.nih.gov/32769414/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,32087613,Pain relief and improvement in quality of life with 10 kHz SCS therapy: Summary of clinical evidence.,2020,10.1111/cns.13285,https://pubmed.ncbi.nlm.nih.gov/32087613/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,31360272,Optimizing the Management and Outcomes of Failed Back Surgery Syndrome: A Proposal of a Standardized Multidisciplinary Team Care Pathway.,2019,10.1155/2019/8184592,https://pubmed.ncbi.nlm.nih.gov/31360272/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,23834386,Predictors of pain relief following spinal cord stimulation in chronic back and leg pain and failed back surgery syndrome: a systematic review and meta-regression analysis.,2014,10.1111/papr.12095,https://pubmed.ncbi.nlm.nih.gov/23834386/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,30860645,"High-Dose Spinal Cord Stimulation for Treatment of Chronic Low Back Pain and Leg Pain in Patients With FBSS, 12-Month Results: A Prospective Pilot Study.",2020,10.1111/ner.12940,https://pubmed.ncbi.nlm.nih.gov/30860645/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP3R2,ENSG00000188386,Neither,27270723,"Knowledge, Perceptions and Attitudes toward Chronic Pain and Its Management: A Cross-Sectional Survey of Frontline Pharmacists in Ontario, Canada.",2016,10.1371/journal.pone.0157151,https://pubmed.ncbi.nlm.nih.gov/27270723/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP4R3C,ENSG00000224960,Neither,41514165,Integrated fetal testicular transcriptomic and epigenomic profiles during maternal nutrient restriction with dietary melatonin intervention.,2026,10.1093/jas/skaf455,https://pubmed.ncbi.nlm.nih.gov/41514165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP4R3C,ENSG00000224960,Neither,35144552,High male specific contribution of the X-chromosome to individual global recombination rate in dairy cattle.,2022,10.1186/s12864-022-08328-8,https://pubmed.ncbi.nlm.nih.gov/35144552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP4R3C,ENSG00000224960,Neither,26859687,Bone biology-related gingival transcriptome in ageing and periodontitis in non-human primates.,2016,10.1111/jcpe.12528,https://pubmed.ncbi.nlm.nih.gov/26859687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAMEF1,ENSG00000116721,Neither,42736378,APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease.,2026,10.1038/s41588-026-02713-9,https://pubmed.ncbi.nlm.nih.gov/42736378/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAMEF1,ENSG00000116721,Neither,38622061,Longitudinal profiling of human androgenotes through single-cell analysis unveils paternal gene expression dynamics in early embryo development.,2024,10.1093/humrep/deae072,https://pubmed.ncbi.nlm.nih.gov/38622061/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAMEF1,ENSG00000116721,Neither,33177874,"HNRNPCL1, PRAMEF1, CFAP74, and DFFB: Common Potential Biomarkers for Sporadic and Suspected Lynch Syndrome Endometrial Cancer.",2020,10.2147/cmar.s262421,https://pubmed.ncbi.nlm.nih.gov/33177874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAMEF12,ENSG00000116726,Neither,38913622,"PRAMEF12, a novel cancer/testis gene, regulates proliferation and apoptosis to promote progression of glioma.",2024,10.2217/bmm-2023-0219,https://pubmed.ncbi.nlm.nih.gov/38913622/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAMEF12,ENSG00000116726,Neither,35592616,Pramef12 enhances reprogramming into naïve iPS cells.,2022,10.1016/j.bbrep.2022.101267,https://pubmed.ncbi.nlm.nih.gov/35592616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAMEF12,ENSG00000116726,Neither,37451217,"MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.",2023,10.1016/j.bbrc.2023.07.013,https://pubmed.ncbi.nlm.nih.gov/37451217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAMEF12,ENSG00000116726,Neither,31729367,Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.,2019,10.1038/s41467-019-13193-3,https://pubmed.ncbi.nlm.nih.gov/31729367/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAMEF12,ENSG00000116726,Neither,33049985,Investigating the Transition of Pre-Symptomatic to Symptomatic Huntington's Disease Status Based on Omics Data.,2020,10.3390/ijms21197414,https://pubmed.ncbi.nlm.nih.gov/33049985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAMEF13,ENSG00000279169,Neither,31349012,Variants at potential loci associated with Sjogren's syndrome in Koreans: A genetic association study.,2019,10.1016/j.clim.2019.07.010,https://pubmed.ncbi.nlm.nih.gov/31349012/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAMEF13,ENSG00000279169,Neither,25765001,Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma.,2015,10.1038/srep09079,https://pubmed.ncbi.nlm.nih.gov/25765001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAMEF15,ENSG00000204501,Neither,40884237,Genetic differences between primary colorectal cancer and its paired synchronous and metachronous metastases.,2026,10.1002/ijc.70116,https://pubmed.ncbi.nlm.nih.gov/40884237/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAMEF2,ENSG00000120952,Neither,41020920,Multilayered insights into the full spectrum of diffuse gliomas: a novel prognostic evaluation model.,2025,10.1007/s12672-025-03551-7,https://pubmed.ncbi.nlm.nih.gov/41020920/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAMEF2,ENSG00000120952,Neither,34593639,PRAMEF2-mediated dynamic regulation of YAP signaling promotes tumorigenesis.,2021,10.1073/pnas.2105523118,https://pubmed.ncbi.nlm.nih.gov/34593639/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAMEF2,ENSG00000120952,Neither,40452939,SK4 potentially modulates the alternative splicing profile associated with papillary thyroid cancer development in BHT101 cells.,2025,10.7717/peerj.19391,https://pubmed.ncbi.nlm.nih.gov/40452939/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAMEF2,ENSG00000120952,Neither,28298930,Predicting the Remaining Lifespan and Cultivation-Related Loss of Osteogenic Capacity of Bone Marrow Multipotential Stromal Cells Applicable across a Broad Donor Age Range.,2017,10.1155/2017/6129596,https://pubmed.ncbi.nlm.nih.gov/28298930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAMEF2,ENSG00000120952,Neither,24755407,Proof of principle: quality control of therapeutic cell preparations using senescence-associated DNA-methylation changes.,2014,10.1186/1756-0500-7-254,https://pubmed.ncbi.nlm.nih.gov/24755407/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAMEF4,ENSG00000243073,Neither,41226651,Epigenetic Impact of Sleep Timing in Children: Novel DNA Methylation Signatures via SWAG Analysis.,2025,10.3390/ijms262110615,https://pubmed.ncbi.nlm.nih.gov/41226651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAMEF4,ENSG00000243073,Neither,27240091,Landscape of tumor-infiltrating T cell repertoire of human cancers.,2016,10.1038/ng.3581,https://pubmed.ncbi.nlm.nih.gov/27240091/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,42885990,A Review of PRDM13 Transcriptional Regulation in Vertebrate Retinal Development and Disease.,2026,10.1167/iovs.67.12.33,https://pubmed.ncbi.nlm.nih.gov/42885990/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,40721003,PRDM13 is required for specification of PAX2 lineage inhibitory neurons in the developing cerebellum.,2025,10.1016/j.ydbio.2025.07.012,https://pubmed.ncbi.nlm.nih.gov/40721003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,40824246,Elevated PRDM13 Disrupts Photoreceptor Function and Survival in the Mammalian Retina.,2025,10.1167/iovs.66.11.38,https://pubmed.ncbi.nlm.nih.gov/40824246/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,41285996,Prognostic value assessment and in vitro validation of mitochondria-ferroptosis-related genes in multiple myeloma.,2025,10.1038/s41598-025-25476-5,https://pubmed.ncbi.nlm.nih.gov/41285996/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,40409260,"A zinc finger-dependent, PRDM13-driven mechanism regulates retinal progenitor cell fate from mouse embryonic stem cells via WNT signaling.",2025,10.1016/j.stemcr.2025.102508,https://pubmed.ncbi.nlm.nih.gov/40409260/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,40868158,Hidden in the Genome: The First Italian Family with North Carolina Macular Dystrophy Carrying a Novel &lt;i&gt;PRDM13&lt;/i&gt; and &lt;i&gt;CCNC&lt;/i&gt; Duplication.,2025,10.3390/biomedicines13081904,https://pubmed.ncbi.nlm.nih.gov/40868158/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,42557242,Identification of methylation-sensitive human transcription factors using meSMiLE-seq.,2026,10.1038/s41467-026-71387-y,https://pubmed.ncbi.nlm.nih.gov/42557242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,39959174,A novel &lt;i&gt;PRDM13&lt;/i&gt; gene duplication causing congenital North Carolina macular dystrophy phenotype in a Mexican family.,2024,,https://pubmed.ncbi.nlm.nih.gov/39959174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,34730112,A recessive PRDM13 mutation results in congenital hypogonadotropic hypogonadism and cerebellar hypoplasia.,2021,10.1172/jci141587,https://pubmed.ncbi.nlm.nih.gov/34730112/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,37990144,Probable human origin of the SARS-CoV-2 polybasic furin cleavage motif.,2023,10.1186/s12863-023-01169-8,https://pubmed.ncbi.nlm.nih.gov/37990144/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,37045472,"Sleep-wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice.",2023,10.26508/lsa.202301992,https://pubmed.ncbi.nlm.nih.gov/37045472/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,36243009,"Multi-omics approach dissects cis-regulatory mechanisms underlying North Carolina macular dystrophy, a retinal enhanceropathy.",2022,10.1016/j.ajhg.2022.09.013,https://pubmed.ncbi.nlm.nih.gov/36243009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,38601016,Two novel non-coding single nucleotide variants in the DNase1 hypersensitivity site of PRDM13 causing North Carolina macular dystrophy in Korea.,2024,,https://pubmed.ncbi.nlm.nih.gov/38601016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,35390279,Recessive PRDM13 mutations cause fatal perinatal brainstem dysfunction with cerebellar hypoplasia and disrupt Purkinje cell differentiation.,2022,10.1016/j.ajhg.2022.03.010,https://pubmed.ncbi.nlm.nih.gov/35390279/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,36344539,"The diagnostic yield, candidate genes, and pitfalls for a genetic study of intellectual disability in 118 middle eastern families.",2022,10.1038/s41598-022-22036-z,https://pubmed.ncbi.nlm.nih.gov/36344539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,33809237,Investigation of PRDM10 and PRDM13 Expression in Developing Mouse Embryos by an Optimized PACT-Based Embryo Clearing Method.,2021,10.3390/ijms22062892,https://pubmed.ncbi.nlm.nih.gov/33809237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,31069014,Large-scale in-silico identification of a tumor-specific antigen pool for targeted immunotherapy in triple-negative breast cancer.,2019,10.18632/oncotarget.26808,https://pubmed.ncbi.nlm.nih.gov/31069014/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,34125159,North Carolina Macular Dystrophy: Phenotypic Variability and Computational Analysis of Disease-Associated Noncoding Variants.,2021,10.1167/iovs.62.7.16,https://pubmed.ncbi.nlm.nih.gov/34125159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,36402981,The possible pathogenesis of macular caldera in patients with North Carolina macular dystrophy.,2022,10.1186/s12886-022-02655-w,https://pubmed.ncbi.nlm.nih.gov/36402981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,34526759,A novel duplication involving PRDM13 in a Turkish family supports its role in North Carolina macular dystrophy (NCMD/MCDR1).,2021,,https://pubmed.ncbi.nlm.nih.gov/34526759/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,29258872,Prdm13 is required for Ebf3+ amacrine cell formation in the retina.,2018,10.1016/j.ydbio.2017.12.003,https://pubmed.ncbi.nlm.nih.gov/29258872/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,25995483,Prdm13 regulates subtype specification of retinal amacrine interneurons and modulates visual sensitivity.,2015,10.1523/jneurosci.0089-15.2015,https://pubmed.ncbi.nlm.nih.gov/25995483/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,26507665,North Carolina Macular Dystrophy Is Caused by Dysregulation of the Retinal Transcription Factor PRDM13.,2016,10.1016/j.ophtha.2015.10.006,https://pubmed.ncbi.nlm.nih.gov/26507665/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,32917921,Single-step genome-wide association study for social genetic effects and direct genetic effects on growth in Landrace pigs.,2020,10.1038/s41598-020-71647-x,https://pubmed.ncbi.nlm.nih.gov/32917921/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM13,ENSG00000112238,Neither,12800201,Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries.,2003,10.1002/ijc.11208,https://pubmed.ncbi.nlm.nih.gov/12800201/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,42449632,Interaction Between PRDM14 and CBFA2T2 Supports Pluripotency and Proliferation in Germ Cell Tumors.,2026,10.3390/cancers18132090,https://pubmed.ncbi.nlm.nih.gov/42449632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,41448293,PRDM14 promotes the bovine somatic stem cell reprogramming through enhancing oxidative phosphorylation at the initial stage.,2026,10.1016/j.gene.2025.149978,https://pubmed.ncbi.nlm.nih.gov/41448293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,41267649,Lineage-specific enhancer insertions regulate Prdm14 to drive the rapid transition from naïve to formative pluripotency in rodents.,2025,10.1242/dev.204886,https://pubmed.ncbi.nlm.nih.gov/41267649/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,40087379,Functional and molecular single-cell analyses implicate PRDM14 in the initiation of B cell leukemia in mice.,2025,10.1038/s41598-025-93043-z,https://pubmed.ncbi.nlm.nih.gov/40087379/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,40856954,"PRDM14 promoted NSCLC cell proliferation, migration and invasion via modulating H3K27me3-mediated PEBP1/Raf-1/MEK/ERK MAPK signaling.",2025,10.1007/s13258-025-01631-0,https://pubmed.ncbi.nlm.nih.gov/40856954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,40866999,Sex-biased transcriptome in in vitro produced bovine early embryos.,2025,10.1186/s13578-025-01459-x,https://pubmed.ncbi.nlm.nih.gov/40866999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,41233591,A primordial germ cell-like-cell platform enables CRISPRi screen for epigenetic fertility modifiers.,2025,10.1038/s44319-025-00633-z,https://pubmed.ncbi.nlm.nih.gov/41233591/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,39938772,PRDM14 is essential for vertebrate gastrulation and safeguards avian germ cell identity.,2025,10.1016/j.ydbio.2025.02.005,https://pubmed.ncbi.nlm.nih.gov/39938772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,41882225,FGF4 initiates X-chromosome inactivation via activating YY1 and prompting loss of pluripotency factors.,2026,10.1038/s44318-026-00722-2,https://pubmed.ncbi.nlm.nih.gov/41882225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,40803291,Transcription factor-mediated germ cell induction in rats reveals ETV4 cooperates with germline specifiers.,2025,10.1016/j.stemcr.2025.102599,https://pubmed.ncbi.nlm.nih.gov/40803291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,38840106,Integrated analysis of the role of PR/SET domain 14 in gastric cancer.,2024,10.1186/s12885-024-12424-1,https://pubmed.ncbi.nlm.nih.gov/38840106/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,39994175,Maternal PRDM10 activates essential genes for oocyte-to-embryo transition.,2025,10.1038/s41467-025-56991-8,https://pubmed.ncbi.nlm.nih.gov/39994175/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,39791560,Maternal Exposure to Polystyrene Nanoplastics Disrupts Spermatogenesis in Mouse Offspring by Inducing Prdm14 Overexpression in Undifferentiated Spermatogonia.,2025,10.1021/acsnano.4c10701,https://pubmed.ncbi.nlm.nih.gov/39791560/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,39358551,SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function.,2024,10.1038/s44319-024-00272-w,https://pubmed.ncbi.nlm.nih.gov/39358551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,41775161,"Generation of chimeric chickens resistant to infection by avian leukemia virus subgroups A, B, D, E, and K through primordial germ cells.",2026,10.1016/j.psj.2026.106642,https://pubmed.ncbi.nlm.nih.gov/41775161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,38710919,PRDM14 extinction enables the initiation of trophoblast stem cell formation.,2024,10.1007/s00018-024-05237-9,https://pubmed.ncbi.nlm.nih.gov/38710919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,38309502,Inhibition of protein kinase C increases Prdm14 level to promote self-renewal of embryonic stem cells through reducing Suv39h-induced H3K9 methylation.,2024,10.1016/j.jbc.2024.105714,https://pubmed.ncbi.nlm.nih.gov/38309502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,41359380,Nanoscale dynamics of enhancer-promoter interactions during exit from pluripotency.,2025,10.1093/nar/gkaf1255,https://pubmed.ncbi.nlm.nih.gov/41359380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,40940741,Establishment of a CRISPR/dCas9 Activation Library for Screening Transcription Factors Co-Regulating OCT4 with GATA4 in Pig Cells.,2025,10.3390/cells14171330,https://pubmed.ncbi.nlm.nih.gov/40940741/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,38992676,"Mesomelia-synostoses syndrome: contiguous deletion syndrome, SULF1 haploinsufficiency or enhancer adoption?",2024,10.1186/s13039-024-00684-2,https://pubmed.ncbi.nlm.nih.gov/38992676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,35908955,Therapeutic siRNA targeting the cancer cell stemness regulator PRDI-BF1 and RIZ domain zinc finger protein 14.,2022,10.2183/pjab.98.017,https://pubmed.ncbi.nlm.nih.gov/35908955/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,33783816,Treatment of primary and metastatic breast and pancreatic tumors upon intravenous delivery of a PRDM14-specific chimeric siRNA/nanocarrier complex.,2021,10.1002/ijc.33579,https://pubmed.ncbi.nlm.nih.gov/33783816/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,31741141,PRDM14 promotes malignant phenotype and correlates with poor prognosis in colorectal cancer.,2020,10.1007/s12094-019-02239-z,https://pubmed.ncbi.nlm.nih.gov/31741141/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,31015254,The Pluripotency Regulator PRDM14 Requires Hematopoietic Regulator CBFA2T3 to Initiate Leukemia in Mice.,2019,10.1158/1541-7786.mcr-18-1327,https://pubmed.ncbi.nlm.nih.gov/31015254/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,37980029,Perfluorinated iodine alkanes promote the differentiation of mouse embryonic stem cells by regulating estrogen receptor signaling.,2024,10.1016/j.jes.2023.02.017,https://pubmed.ncbi.nlm.nih.gov/37980029/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,30338223,PRDM14 is overexpressed in chronic pancreatitis prior to pancreatic cancer.,2018,10.1002/2211-5463.12519,https://pubmed.ncbi.nlm.nih.gov/30338223/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,31130394,Off to a Bad Start: Cancer Initiation by Pluripotency Regulator PRDM14.,2019,10.1016/j.tig.2019.04.004,https://pubmed.ncbi.nlm.nih.gov/31130394/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,38154448,Wnt signaling blockade is essential for maintaining the pluripotency of chicken embryonic stem cells.,2024,10.1016/j.psj.2023.103361,https://pubmed.ncbi.nlm.nih.gov/38154448/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,37053002,NR5A2 as a potential target for exercise to improve metabolic syndrome.,2023,10.18632/aging.204606,https://pubmed.ncbi.nlm.nih.gov/37053002/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,30155811,"PRDM14, a Zinc Finger Protein, Regulates Cancer Stemness.",2018,10.1007/978-1-4939-8799-3_1,https://pubmed.ncbi.nlm.nih.gov/30155811/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,29178343,PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78.,2018,10.1111/cas.13458,https://pubmed.ncbi.nlm.nih.gov/29178343/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,28498896,Inhibition of PRDM14 expression in pancreatic cancer suppresses cancer stem-like properties and liver metastasis in mice.,2017,10.1093/carcin/bgx040,https://pubmed.ncbi.nlm.nih.gov/28498896/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,28423353,"Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer.",2017,10.18632/oncotarget.16776,https://pubmed.ncbi.nlm.nih.gov/28423353/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,27106930,PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.,2016,10.1242/bio.017699,https://pubmed.ncbi.nlm.nih.gov/27106930/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,35333572,Genome-wide screening identifies Polycomb repressive complex 1.3 as an essential regulator of human naïve pluripotent cell reprogramming.,2022,10.1126/sciadv.abk0013,https://pubmed.ncbi.nlm.nih.gov/35333572/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,30185410,Targeted DamID reveals differential binding of mammalian pluripotency factors.,2018,10.1242/dev.170209,https://pubmed.ncbi.nlm.nih.gov/30185410/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,26523391,ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation.,2015,10.7554/elife.10150,https://pubmed.ncbi.nlm.nih.gov/26523391/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,20953172,A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity.,2010,10.1038/nature09531,https://pubmed.ncbi.nlm.nih.gov/20953172/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM14,ENSG00000147596,Neither,17942894,Gene amplification and overexpression of PRDM14 in breast cancers.,2007,10.1158/0008-5472.can-06-4111,https://pubmed.ncbi.nlm.nih.gov/17942894/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,42854377,Meiotic recombination proteins in cancer.,2026,10.1016/j.dnarep.2026.103963,https://pubmed.ncbi.nlm.nih.gov/42854377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,41574437,A novel dual histone mark reader ZCWPW2 regulates meiotic recombination through lactylation and transcriptional regulation in humans and mice.,2026,10.1093/nar/gkag049,https://pubmed.ncbi.nlm.nih.gov/41574437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,42825118,Quercetin Alleviates Ferroptosis-Induced Renal Fibrosis by Modulating the PRDM9/HMOX1/PTGS2 Axis.,2026,10.1021/acsomega.6c05732,https://pubmed.ncbi.nlm.nih.gov/42825118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,42846478,Whole genome sequencing approach for the detection of rare protein-altering variants associated with familial male infertility.,2025,10.1186/s43042-025-00828-y,https://pubmed.ncbi.nlm.nih.gov/42846478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,41397959,Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma.,2025,10.1038/s41467-025-65888-5,https://pubmed.ncbi.nlm.nih.gov/41397959/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,42649296,Long-read sequencing reveals pre-meiotic gene conversion in sperm.,2026,10.1038/s41586-026-10901-0,https://pubmed.ncbi.nlm.nih.gov/42649296/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,40881324,"ACTN2, regulated by PRDM9, affects the growth and inflammation of vascular smooth muscle cells by interacting with PDLIM1 in intracranial aneurysms.",2025,10.3389/fnmol.2025.1606973,https://pubmed.ncbi.nlm.nih.gov/40881324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,42250889,PRDM9 Deficiency Drives Mosaic Promoter Deletions in Sporadic Hirschsprung Disease and Supports Blood-Based Molecular Stratification.,2026,10.1053/j.gastro.2026.05.020,https://pubmed.ncbi.nlm.nih.gov/42250889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,41820541,Beyond the Prdm9 model: independent evolution of hybrid male sterility in house mice.,2026,10.1038/s41437-026-00834-9,https://pubmed.ncbi.nlm.nih.gov/41820541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,42896821,LSD1 exerts crucial functions to drive the progression of meiotic prophase I during spermatogenesis.,2026,10.1016/j.jgg.2026.10.008,https://pubmed.ncbi.nlm.nih.gov/42896821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,40003887,Characterization of PRDM9 Multifunctionality in Yak Testes Through Protein Interaction Mapping.,2025,10.3390/ijms26041420,https://pubmed.ncbi.nlm.nih.gov/40003887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,42510835,The Role of the &lt;i&gt;Msh2&lt;/i&gt; Mismatch Repair Gene in the &lt;i&gt;Prdm9&lt;/i&gt;-Driven Hybrid Male Sterility in the House Mouse.,2026,10.3390/genes17070795,https://pubmed.ncbi.nlm.nih.gov/42510835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,42483966,Sex-Specific Landscapes of Crossover and Noncrossover Recombination in Coppery Titi Monkeys (Plecturocebus cupreus).,2026,10.1093/gbe/evag186,https://pubmed.ncbi.nlm.nih.gov/42483966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,41037637,Mouse X-linked microRNA cluster regulates the meiotic checkpoint and &lt;i&gt;Prdm9&lt;/i&gt;-driven hybrid sterility in a copy number-dependent manner.,2025,10.1073/pnas.2510229122,https://pubmed.ncbi.nlm.nih.gov/41037637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,41285744,Long-read sequencing of primate testis and human sperm allows identification of recombination events in individuals.,2025,10.1038/s41467-025-65248-3,https://pubmed.ncbi.nlm.nih.gov/41285744/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,39761307,PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish.,2025,10.1371/journal.pbio.3002950,https://pubmed.ncbi.nlm.nih.gov/39761307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,42415090,Whole exome sequencing uncovers genetic syndromes and putative candidate genes underlying orofacial clefts presenting with limb abnormalities in a Sub-Saharan African cohort.,2026,10.1186/s12920-026-02426-2,https://pubmed.ncbi.nlm.nih.gov/42415090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,40199997,Phenogenomic resources immortalized in a panel of wild-derived strains of five species of house mice.,2025,10.1038/s41598-025-86505-x,https://pubmed.ncbi.nlm.nih.gov/40199997/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,36967403,The RNA-binding protein FUS/TLS interacts with SPO11 and PRDM9 and localize at meiotic recombination hotspots.,2023,10.1007/s00018-023-04744-5,https://pubmed.ncbi.nlm.nih.gov/36967403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,40918063,A high-resolution meiotic crossover map from single-nucleus ATAC-seq reveals insights into the recombination landscape in mammals.,2025,10.1093/nargab/lqaf122,https://pubmed.ncbi.nlm.nih.gov/40918063/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,40111008,Epigenetic Regulation of CD8&lt;sup&gt;+&lt;/sup&gt; Effector T Cell Differentiation by PDCD5.,2025,10.1002/eji.202451388,https://pubmed.ncbi.nlm.nih.gov/40111008/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,39850492,Variability of PRDM9 in buffaloes.,2024,10.3389/fgene.2024.1479287,https://pubmed.ncbi.nlm.nih.gov/39850492/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,38217871,Natural variation in the zinc-finger-encoding exon of Prdm9 affects hybrid sterility phenotypes in mice.,2024,10.1093/genetics/iyae004,https://pubmed.ncbi.nlm.nih.gov/38217871/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,37608663,"FBLN5 was Regulated by PRDM9, and Promoted Senescence and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells.",2024,10.2174/1574888x18666230822100054,https://pubmed.ncbi.nlm.nih.gov/37608663/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,38513632,Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9.,2024,10.1093/molbev/msae063,https://pubmed.ncbi.nlm.nih.gov/38513632/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,39155614,A Novel RNA Methylation-Related Prognostic Signature and its Tumor Microenvironment Characterization in Hepatocellular Carcinoma.,2024,10.1177/15330338241276895,https://pubmed.ncbi.nlm.nih.gov/39155614/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,41157092,Role of Histone H3 Lysine 4 Methylation in Chromatin Biology.,2025,10.3390/molecules30204075,https://pubmed.ncbi.nlm.nih.gov/41157092/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,38566223,Full-spectral genome analysis of natural killer/T cell lymphoma highlights impacts of genome instability in driving its progression.,2024,10.1186/s13073-024-01324-5,https://pubmed.ncbi.nlm.nih.gov/38566223/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,36156073,Systems-level identification of key transcription factors in immune cell specification.,2022,10.1371/journal.pcbi.1010116,https://pubmed.ncbi.nlm.nih.gov/36156073/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,31848333,Discovery of a chemical probe for PRDM9.,2019,10.1038/s41467-019-13652-x,https://pubmed.ncbi.nlm.nih.gov/31848333/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,36754567,A novel hypervariable variable number tandem repeat in the dopamine transporter gene (SLC6A3).,2023,10.26508/lsa.202201677,https://pubmed.ncbi.nlm.nih.gov/36754567/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,37759801,Presenilin-1-Derived Circular RNAs: Neglected Epigenetic Regulators with Various Functions in Alzheimer's Disease.,2023,10.3390/biom13091401,https://pubmed.ncbi.nlm.nih.gov/37759801/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,33774927,The duality of PRDM proteins: epigenetic and structural perspectives.,2022,10.1111/febs.15844,https://pubmed.ncbi.nlm.nih.gov/33774927/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,35522148,Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas.,2023,10.3324/haematol.2021.280005,https://pubmed.ncbi.nlm.nih.gov/35522148/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,35819819,Assessing the Immune Cell Subset and Genetic Mutations in Patients With Palindromic Rheumatism Seronegative for Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide.,2023,10.1002/art.42297,https://pubmed.ncbi.nlm.nih.gov/35819819/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,34122517,Haplotype Shuffling and Dimorphic Transposable Elements in the Human Extended Major Histocompatibility Complex Class II Region.,2021,10.3389/fgene.2021.665899,https://pubmed.ncbi.nlm.nih.gov/34122517/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,31028697,Divergent Fine-Scale Recombination Landscapes between a Freshwater and Marine Population of Threespine Stickleback Fish.,2019,10.1093/gbe/evz090,https://pubmed.ncbi.nlm.nih.gov/31028697/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,28155083,The long zinc finger domain of PRDM9 forms a highly stable and long-lived complex with its DNA recognition sequence.,2017,10.1007/s10577-017-9552-1,https://pubmed.ncbi.nlm.nih.gov/28155083/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRDM9,ENSG00000164256,Neither,25001002,Primate evolution of the recombination regulator PRDM9.,2014,10.1038/ncomms5370,https://pubmed.ncbi.nlm.nih.gov/25001002/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR20A,ENSG00000204919,Neither,31204702,Clinical presentation and genetic profiles of Chinese patients with velocardiofacial syndrome in a large referral centre.,2019,10.1007/s12041-019-1090-5,https://pubmed.ncbi.nlm.nih.gov/31204702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR23A,ENSG00000206260,Neither,42087103,"Rare coding variation and stroke heterogeneity in Saudi Arabia: an exome‑wide association study across severity, etiology, vascular territory, and early‑onset disease.",2026,10.1186/s12883-026-04935-0,https://pubmed.ncbi.nlm.nih.gov/42087103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR23A,ENSG00000206260,Neither,35505416,Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis.,2022,10.1186/s13148-022-01276-w,https://pubmed.ncbi.nlm.nih.gov/35505416/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR23B,ENSG00000184814,Neither,34142482,DNA Methylation Differences in Peripheral Blood of Patients with Anaphylaxis.,2021,10.12116/j.issn.1004-5619.2019.490414,https://pubmed.ncbi.nlm.nih.gov/34142482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR23E,ENSG00000214324,Neither,29396444,Differential long non-coding RNA expression profiles in human oocytes and cumulus cells.,2018,10.1038/s41598-018-20727-0,https://pubmed.ncbi.nlm.nih.gov/29396444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS38,ENSG00000185888,Neither,41373827,PRSS38 Is a Novel Sperm Serine Protease Involved in Human and Mouse Fertilization.,2025,10.3390/ijms262311680,https://pubmed.ncbi.nlm.nih.gov/41373827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS38,ENSG00000185888,Neither,41108903,Sono-processing treatments enhanced the stability and digestive properties of soy-myofibrillar dual-protein systems.,2025,10.1016/j.ultsonch.2025.107613,https://pubmed.ncbi.nlm.nih.gov/41108903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS41,ENSG00000215148,Neither,38678957,A new high-throughput screening methodology for the discovery of cancer-testis antigen using multi-omics data.,2024,10.1016/j.cmpb.2024.108193,https://pubmed.ncbi.nlm.nih.gov/38678957/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS41,ENSG00000215148,Neither,38486936,Identification of FLRT2 as a key prognostic gene through a comprehensive analysis of TMB and IRGPs in BLCA patients.,2023,10.3389/fonc.2023.1229227,https://pubmed.ncbi.nlm.nih.gov/38486936/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS41,ENSG00000215148,Neither,24129193,"A testis-specific serine protease, Prss41/Tessp-1, is necessary for the progression of meiosis during murine in vitro spermatogenesis.",2013,10.1016/j.bbrc.2013.10.028,https://pubmed.ncbi.nlm.nih.gov/24129193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS41,ENSG00000215148,Neither,30374992,Searching for tryptase in the RBL-2H3 mast cell model: Preparation for comparative mast cell toxicology studies with zebrafish.,2019,10.1002/jat.3738,https://pubmed.ncbi.nlm.nih.gov/30374992/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA8,ENSG00000154611,Neither,41972436,PSMA8-Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility.,2026,10.1002/advs.202520292,https://pubmed.ncbi.nlm.nih.gov/41972436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA8,ENSG00000154611,Neither,41167419,The constitutive 20S proteasome is required for the maintenance and differentiation of spermatogonia in mice.,2026,10.1016/j.jare.2025.10.068,https://pubmed.ncbi.nlm.nih.gov/41167419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA8,ENSG00000154611,Neither,42366378,Phenotyping of post-fertilization sperm mitophagy determinants discovered in a mammalian gamete-based cell-free system.,2026,10.1186/s40659-026-00713-x,https://pubmed.ncbi.nlm.nih.gov/42366378/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA8,ENSG00000154611,Neither,42826827,Perfluorooctanoic acid exposure inhibits round spermatid elongation by impeding ubiquitin-proteasome-mediated chromatin remodeling in mice.,2026,10.1016/j.tox.2026.154608,https://pubmed.ncbi.nlm.nih.gov/42826827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA8,ENSG00000154611,Neither,40068345,Comparative proteomic and transcriptomic analysis of testicular tissue of yaks with or without cryptorchidism.,2025,10.1016/j.theriogenology.2025.117376,https://pubmed.ncbi.nlm.nih.gov/40068345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA8,ENSG00000154611,Neither,42059593,"The synaptonemal complex: structure, function, and clinical implications†.",2026,10.1093/biolre/ioag092,https://pubmed.ncbi.nlm.nih.gov/42059593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA8,ENSG00000154611,Neither,38225540,Lnc-PSMA8-1 activated by GEFT promotes rhabdomyosarcoma progression via upregulation of mTOR expression by sponging miR-144-3p.,2024,10.1186/s12885-023-11798-y,https://pubmed.ncbi.nlm.nih.gov/38225540/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA8,ENSG00000154611,Neither,35736136,H3K36me2 methyltransferase NSD2 orchestrates epigenetic reprogramming during spermatogenesis.,2022,10.1093/nar/gkac533,https://pubmed.ncbi.nlm.nih.gov/35736136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA8,ENSG00000154611,Neither,41141246,Prediction of Immunotherapy Response and Prognostic Outcomes for Patients With Ovarian Cancer Using PANoptosis-Related Genes.,2025,10.1155/humu/7108361,https://pubmed.ncbi.nlm.nih.gov/41141246/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA8,ENSG00000154611,Neither,31437213,The PSMA8 subunit of the spermatoproteasome is essential for proper meiotic exit and mouse fertility.,2019,10.1371/journal.pgen.1008316,https://pubmed.ncbi.nlm.nih.gov/31437213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA8,ENSG00000154611,Neither,31358751,Meiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome.,2019,10.1038/s41467-019-11346-y,https://pubmed.ncbi.nlm.nih.gov/31358751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA8,ENSG00000154611,Neither,36035152,Analysis of the Prognostic Significance and Immune Infiltration of the Amino Acid Metabolism-Related Genes in Colon Adenocarcinoma.,2022,10.3389/fgene.2022.951461,https://pubmed.ncbi.nlm.nih.gov/36035152/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA8,ENSG00000154611,Neither,33262216,Proteasome subunit α4s is essential for formation of spermatoproteasomes and histone degradation during meiotic DNA repair in spermatocytes.,2021,10.1074/jbc.ra120.016485,https://pubmed.ncbi.nlm.nih.gov/33262216/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA8,ENSG00000154611,Neither,34943457,Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer.,2021,10.3390/diagnostics11122220,https://pubmed.ncbi.nlm.nih.gov/34943457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA8,ENSG00000154611,Neither,34253331,Deoxyribonucleic acid methylation signatures in sperm deoxyribonucleic acid fragmentation.,2021,10.1016/j.fertnstert.2021.06.025,https://pubmed.ncbi.nlm.nih.gov/34253331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA8,ENSG00000154611,Neither,23706739,Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis.,2013,10.1016/j.cell.2013.04.032,https://pubmed.ncbi.nlm.nih.gov/23706739/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA8,ENSG00000154611,Neither,29547645,"Recurrent, low-frequency coding variants contributing to colorectal cancer in the Swedish population.",2018,10.1371/journal.pone.0193547,https://pubmed.ncbi.nlm.nih.gov/29547645/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,41585794,Neuropeptide TIP39 as a pluripotent brain molecule and its potential functions in postpartum depression.,2025,10.3389/fendo.2025.1674213,https://pubmed.ncbi.nlm.nih.gov/41585794/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,42267139,Integrated Multi-Tissue Transcriptomics Reveals Antagonistic Pleiotropy in Aging and Alzheimer's Disease.,2026,10.34133/csbj.0134,https://pubmed.ncbi.nlm.nih.gov/42267139/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,40287908,Neuropeptide TIP39 induces autophagy in PTH2 receptor-positive myeloid neoplasms.,2025,10.1007/s12185-025-03985-3,https://pubmed.ncbi.nlm.nih.gov/40287908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,42626907,Structural and functional analysis of peptidyl-tRNA hydrolase 2 from Candidatus Lokiarchaeum sp. GC14_75.,2026,10.1107/s2053230x26008423,https://pubmed.ncbi.nlm.nih.gov/42626907/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,41387170,Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive-Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39-PTH2R Signaling.,2026,10.1002/advs.202512170,https://pubmed.ncbi.nlm.nih.gov/41387170/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,40089475,Single-cell and chromatin accessibility profiling reveals regulatory programs of pathogenic Th2 cells in allergic asthma.,2025,10.1038/s41467-025-57590-3,https://pubmed.ncbi.nlm.nih.gov/40089475/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,40297711,Decoding migraine disorders: parathyroid hormone-related peptide receptors as key genetic drivers.,2025,10.1093/braincomms/fcaf142,https://pubmed.ncbi.nlm.nih.gov/40297711/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,37240884,Parathyroid Hormone (PTH)-Related Peptides Family: An Intriguing Role in the Central Nervous System.,2023,10.3390/jpm13050714,https://pubmed.ncbi.nlm.nih.gov/37240884/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,42770292,A WOPR transcriptional regulatory network controls the virulence of the opportunistic fungal pathogen &lt;i&gt;Nakaseomyces glabratus&lt;/i&gt;.,2026,10.1128/spectrum.01865-26,https://pubmed.ncbi.nlm.nih.gov/42770292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,39775138,Maternally activated connections of the ventral lateral septum reveal input from the posterior intralaminar thalamus.,2025,10.1007/s00429-024-02870-9,https://pubmed.ncbi.nlm.nih.gov/39775138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,35499975,Behavioural actions of tuberoinfundibular peptide 39 (parathyroid hormone 2).,2022,10.1111/jne.13130,https://pubmed.ncbi.nlm.nih.gov/35499975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,36161311,Alone in a crowd: effect of a nonfunctional lateral line on expression of the social hormone parathyroid hormone 2.,2022,10.1242/bio.059432,https://pubmed.ncbi.nlm.nih.gov/36161311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,36958466,Synaptoporin and parathyroid hormone 2 as markers of multimodal inputs to the auditory brainstem.,2023,10.1016/j.jchemneu.2023.102259,https://pubmed.ncbi.nlm.nih.gov/36958466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,36295039,An Arabidopsis PTH2 Gene Is Responsible for Gravity Resistance Supporting Plant Growth under Different Gravity Conditions.,2022,10.3390/life12101603,https://pubmed.ncbi.nlm.nih.gov/36295039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,35243231,The neuropeptide Pth2 modulates social behavior and anxiety in zebrafish.,2022,10.1016/j.isci.2022.103868,https://pubmed.ncbi.nlm.nih.gov/35243231/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,33268890,The neuropeptide Pth2 dynamically senses others via mechanosensation.,2020,10.1038/s41586-020-2988-z,https://pubmed.ncbi.nlm.nih.gov/33268890/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,36113471,A thalamo-preoptic pathway promotes social grooming in rodents.,2022,10.1016/j.cub.2022.08.062,https://pubmed.ncbi.nlm.nih.gov/36113471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,39945942,Trypanosoma cruzi has Two Peptidyl-tRNA Hydrolases Showing Different Localization and Function.,2025,10.1007/s11686-025-00989-1,https://pubmed.ncbi.nlm.nih.gov/39945942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,30838650,Molecular mechanism of tuberoinfundibular peptide of 39 on glucocorticoid receptor mediated glutamate/GABA imbalance and cerebral abnormalities against cognitive deficit model.,2019,10.1111/jphp.13085,https://pubmed.ncbi.nlm.nih.gov/30838650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,27000502,The Parathyroid Hormone Second Receptor PTH2R and its Ligand Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate Intracellular Calcium and Influence Keratinocyte Differentiation.,2016,10.1016/j.jid.2016.02.814,https://pubmed.ncbi.nlm.nih.gov/27000502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,20796031,TIP39 modulates effects of novelty-induced arousal on memory.,2011,10.1111/j.1601-183x.2010.00643.x,https://pubmed.ncbi.nlm.nih.gov/20796031/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,36676129,Primary and Metastatic Cutaneous Melanomas Discriminately Enrich Several Ligand-Receptor Interactions.,2023,10.3390/life13010180,https://pubmed.ncbi.nlm.nih.gov/36676129/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,28454729,Activation of Parathyroid Hormone 2 Receptor Induces Decorin Expression and Promotes Wound Repair.,2017,10.1016/j.jid.2017.03.034,https://pubmed.ncbi.nlm.nih.gov/28454729/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,18700839,Increased fear- and stress-related anxiety-like behavior in mice lacking tuberoinfundibular peptide of 39 residues.,2008,10.1111/j.1601-183x.2008.00432.x,https://pubmed.ncbi.nlm.nih.gov/18700839/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,29459818,Gestational Exposure to the Synthetic Cathinone Methylenedioxypyrovalerone Results in Reduced Maternal Care and Behavioral Alterations in Mouse Pups.,2018,10.3389/fnins.2018.00027,https://pubmed.ncbi.nlm.nih.gov/29459818/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,21382418,Enhanced long-term fear memory and increased anxiety and depression-like behavior after exposure to an aversive event in mice lacking TIP39 signaling.,2011,10.1016/j.bbr.2011.02.043,https://pubmed.ncbi.nlm.nih.gov/21382418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,23688767,Evaluating the in vivo Th2 priming potential among common allergens.,2013,10.1016/j.jim.2013.05.004,https://pubmed.ncbi.nlm.nih.gov/23688767/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTH2,ENSG00000142538,Neither,12098667,"Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family.",2002,10.1677/joe.0.1740095,https://pubmed.ncbi.nlm.nih.gov/12098667/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,41366310,Plasma proteomic signatures in HIV-infected individuals post-SARS-CoV-2 infection.,2025,10.1186/s12879-025-12307-1,https://pubmed.ncbi.nlm.nih.gov/41366310/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,42826677,Effect of dose-dense adjuvant chemotherapy in patients with node-positive early breast cancer according to estrogen receptor levels: an exploratory analysis of the GIM2 trial.,2026,10.1016/j.breast.2026.104942,https://pubmed.ncbi.nlm.nih.gov/42826677/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,41230692,Chromosomal rearrangement-enhanced mRNA stability drives the oncogenic potential of fusion genes in pediatric leukemia.,2026,10.3324/haematol.2025.288256,https://pubmed.ncbi.nlm.nih.gov/41230692/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,41945755,A pilot randomized clinical trial of a peer support intervention for hematopoietic stem cell transplantation.,2026,10.1182/bloodadvances.2025018918,https://pubmed.ncbi.nlm.nih.gov/41945755/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,37467697,Mouse Pxt1 expression is regulated by Mir6996 miRNA.,2023,10.1016/j.theriogenology.2023.07.010,https://pubmed.ncbi.nlm.nih.gov/37467697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,42350064,"Pilot study of feasibility, acceptability, and changes in clinical outcomes following a brief trauma-focused intervention for chronic pain.",2026,10.1136/rapm-2026-107849,https://pubmed.ncbi.nlm.nih.gov/42350064/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,37315086,Structural basis for proapoptotic activation of Bak by the noncanonical BH3-only protein Pxt1.,2023,10.1371/journal.pbio.3002156,https://pubmed.ncbi.nlm.nih.gov/37315086/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,42323410,Treatment-aware deep learning enables counterfactual prediction of individual benefit from PARP inhibitors in ovarian cancer.,2026,10.1038/s41746-026-02822-z,https://pubmed.ncbi.nlm.nih.gov/42323410/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,35964379,Structural and biochemical analyses of Bcl-xL in complex with the BH3 domain of peroxisomal testis-specific 1.,2022,10.1016/j.bbrc.2022.08.009,https://pubmed.ncbi.nlm.nih.gov/35964379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,37393946,Increased DNA strand breaks in spermatozoa of Pxt1 knockout mice.,2023,10.1071/rd23061,https://pubmed.ncbi.nlm.nih.gov/37393946/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,39139415,Serum Biomarkers to Dynamically Predict the Risk of Cardiovascular Events in Patients under Oncologic Therapy. A Multicenter Observational Study.,2024,10.31083/j.rcm2507256,https://pubmed.ncbi.nlm.nih.gov/39139415/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,39703564,Benefit from dose-dense adjuvant chemotherapy for breast cancer: subgroup analyses from the randomised phase 3 PANTHER trial.,2025,10.1016/j.lanepe.2024.101162,https://pubmed.ncbi.nlm.nih.gov/39703564/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,36706751,Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization.,2023,10.1016/j.str.2023.01.001,https://pubmed.ncbi.nlm.nih.gov/36706751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,40093800,Association between Triglyceride-Glucose Index and Prognosis in Critically Ill Patients with Acute Coronary Syndrome: Evidence from the MIMIC Database.,2025,10.7150/ijms.107976,https://pubmed.ncbi.nlm.nih.gov/40093800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,40247248,"Adjuvant ovarian function suppression in premenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative early breast cancer: a multi-center retrospective study.",2025,10.1186/s12885-025-14120-0,https://pubmed.ncbi.nlm.nih.gov/40247248/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,32697979,Corneal epithelial biology: Lessons stemming from old to new.,2020,10.1016/j.exer.2020.108094,https://pubmed.ncbi.nlm.nih.gov/32697979/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,36010111,PTSD Risk Factors and Acute Pain Intensity Predict Length of Hospital Stay in Youth after Unintentional Injury.,2022,10.3390/children9081222,https://pubmed.ncbi.nlm.nih.gov/36010111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,37425411,Biomarker analysis of the phase II JO25567 study comparing erlotinib with or without bevacizumab in first-line advanced EGFR+non-small-cell lung cancer.,2023,10.21037/tlcr-22-632,https://pubmed.ncbi.nlm.nih.gov/37425411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,30403842,Chemo-Selection Strategy for Limited Proteolysis Experiments on the Proteomic Scale.,2018,10.1021/acs.analchem.8b04122,https://pubmed.ncbi.nlm.nih.gov/30403842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,31817495,Novel and Rare Fusion Transcripts Involving Transcription Factors and Tumor Suppressor Genes in Acute Myeloid Leukemia.,2019,10.3390/cancers11121951,https://pubmed.ncbi.nlm.nih.gov/31817495/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,39332809,A Peer Support Intervention in Patients With Hematologic Malignancies Undergoing Hematopoietic Stem Cell Transplantation (HSCT): The STEPP Proof-of-Concept Trial.,2024,10.1016/j.jtct.2024.09.022,https://pubmed.ncbi.nlm.nih.gov/39332809/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,39566722,A peer support intervention in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation (HSCT): The STEPP randomized pilot trial design and methods.,2025,10.1016/j.cct.2024.107746,https://pubmed.ncbi.nlm.nih.gov/39566722/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,40187495,A Structured Peer Support Intervention for Patients With Hematologic Malignancies Undergoing Hematopoietic Stem Cell Transplantation: Peer Support Interventionists' Perspectives.,2025,10.1016/j.jtct.2025.03.017,https://pubmed.ncbi.nlm.nih.gov/40187495/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,40007986,ST-segment elevation myocardial infarction for pharmacoinvasive strategy or primary percutaneous coronary intervention in Gaza (STEPP 2- PCI) trial.,2024,10.5114/amsad/195768,https://pubmed.ncbi.nlm.nih.gov/40007986/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,35313167,Six-year absolute invasive disease-free survival benefit of adding adjuvant pertuzumab to trastuzumab and chemotherapy for patients with early HER2-positive breast cancer: A Subpopulation Treatment Effect Pattern Plot (STEPP) analysis of the APHINITY (BIG 4-11) trial.,2022,10.1016/j.ejca.2022.01.031,https://pubmed.ncbi.nlm.nih.gov/35313167/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,37304208,Population Sensitive to Lenvatinib Plus Anti-PD-1 for Unresectable Hepatocellular Carcinoma Infected with Hepatitis B Virus.,2023,10.2147/jhc.s411748,https://pubmed.ncbi.nlm.nih.gov/37304208/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,34593037,Cost-effectiveness of preemptive skin treatment to prevent skin-toxicity caused by panitumumab in third-line therapy for KRAS wild type metastatic colorectal cancer in Japan.,2021,10.1186/s40780-021-00218-7,https://pubmed.ncbi.nlm.nih.gov/34593037/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,38023174,Subpopulation treatment effect pattern plot analysis: a prognostic model for distant recurrence-free survival to estimate delayed adjuvant chemotherapy initiation effect in triple-negative breast cancer.,2023,10.3389/fonc.2023.1193927,https://pubmed.ncbi.nlm.nih.gov/38023174/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,34786794,Worsening renal function in acute heart failure in the context of diuretic response.,2022,10.1002/ejhf.2384,https://pubmed.ncbi.nlm.nih.gov/34786794/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,35382744,Investigating treatment-effect modification by a continuous covariate in IPD meta-analysis: an approach using fractional polynomials.,2022,10.1186/s12874-022-01516-w,https://pubmed.ncbi.nlm.nih.gov/35382744/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PXT1,ENSG00000179165,Neither,34183674,Composite risk and benefit from adjuvant dose-dense chemotherapy in hormone receptor-positive breast cancer.,2021,10.1038/s41523-021-00286-w,https://pubmed.ncbi.nlm.nih.gov/34183674/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBAK-RBAKDN,ENSG00000272968,Neither,41965838,Genome-wide investigation of synthetic rescue interactions in Alzheimer's disease implicates glial lipid and sterol metabolism.,2026,10.1186/s13195-026-02009-4,https://pubmed.ncbi.nlm.nih.gov/41965838/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBAK-RBAKDN,ENSG00000272968,Neither,10702291,"Cloning and characterization of a novel Kruppel-associated box family transcriptional repressor that interacts with the retinoblastoma gene product, RB.",2000,10.1074/jbc.275.10.7212,https://pubmed.ncbi.nlm.nih.gov/10702291/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBAKDN,ENSG00000273313,Neither,41965838,Genome-wide investigation of synthetic rescue interactions in Alzheimer's disease implicates glial lipid and sterol metabolism.,2026,10.1186/s13195-026-02009-4,https://pubmed.ncbi.nlm.nih.gov/41965838/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBAKDN,ENSG00000273313,Neither,34707642,"A Novel Meiosis-Related lncRNA, Rbakdn, Contributes to Spermatogenesis by Stabilizing Ptbp2.",2021,10.3389/fgene.2021.752495,https://pubmed.ncbi.nlm.nih.gov/34707642/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBAKDN,ENSG00000273313,Neither,36992704,Metabolism-related long non-coding RNA in the stomach cancer associated with 11 AMMLs predictive nomograms for OS in STAD.,2023,10.3389/fgene.2023.1127132,https://pubmed.ncbi.nlm.nih.gov/36992704/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBAKDN,ENSG00000273313,Neither,35075611,Constructing a Novel Signature Based on Immune-Related lncRNA to Improve Prognosis Prediction of Cervical Squamous Cell Carcinoma Patients.,2022,10.1007/s43032-022-00851-z,https://pubmed.ncbi.nlm.nih.gov/35075611/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBAKDN,ENSG00000273313,Neither,33111631,Identification of lnc RNAs Related to Prognosis of Patients With Colorectal Cancer.,2020,10.1177/1533033820962120,https://pubmed.ncbi.nlm.nih.gov/33111631/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBAKDN,ENSG00000273313,Neither,32355515,Identification of key lncRNAs as prognostic prediction models for colorectal cancer based on LASSO.,2020,,https://pubmed.ncbi.nlm.nih.gov/32355515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBAKDN,ENSG00000273313,Neither,34526775,Identification and Experimental Validation of Immune-Associate lncRNAs for Predicting Prognosis in Cervical Cancer.,2021,10.2147/ott.s322998,https://pubmed.ncbi.nlm.nih.gov/34526775/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBAKDN,ENSG00000273313,Neither,33588862,A novel prognostic prediction model based on seven immune-related RNAs for predicting overall survival of patients in early cervical squamous cell carcinoma.,2021,10.1186/s12920-021-00885-3,https://pubmed.ncbi.nlm.nih.gov/33588862/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM44,ENSG00000177483,Neither,31995159,Novel localizations and interactions of intercellular bridge proteins revealed by proteomic profiling†.,2020,10.1093/biolre/ioaa017,https://pubmed.ncbi.nlm.nih.gov/31995159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM44,ENSG00000177483,Neither,37050850,Comparative proteomic analysis identifies differentially expressed proteins associated with meiotic arrest in cattle-yak hybrids.,2023,10.1002/pmic.202300107,https://pubmed.ncbi.nlm.nih.gov/37050850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM44,ENSG00000177483,Neither,21364893,Identification and characterization of RBM44 as a novel intercellular bridge protein.,2011,10.1371/journal.pone.0017066,https://pubmed.ncbi.nlm.nih.gov/21364893/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM44,ENSG00000177483,Neither,35116980,"Effect of NOP2 knockdown on colon cancer cell proliferation, migration, and invasion.",2019,10.21037/tcr.2019.09.46,https://pubmed.ncbi.nlm.nih.gov/35116980/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM44,ENSG00000177483,Neither,21669984,Germ cell intercellular bridges.,2011,10.1101/cshperspect.a005850,https://pubmed.ncbi.nlm.nih.gov/21669984/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM44,ENSG00000177483,Neither,22909339,"MicroRNA signature in various cell types of mouse spermatogenesis: evidence for stage-specifically expressed miRNA-221, -203 and -34b-5p mediated spermatogenesis regulation.",2012,10.1111/boc.201200014,https://pubmed.ncbi.nlm.nih.gov/22909339/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFPL4B,ENSG00000251258,Neither,42544237,PTM-Related Signatures Predict Lymph Node Metastasis and Shape Microenvironment in Hepatocellular Carcinoma: A Single-Cell and Bulk Integrated Analysis.,2026,10.2147/jhc.s607916,https://pubmed.ncbi.nlm.nih.gov/42544237/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFPL4B,ENSG00000251258,Neither,39323867,Identification of two heterogeneous subtypes of hepatocellular carcinoma with distinct pathway activities and clinical outcomes based on gene set variation analysis.,2024,10.3389/fgene.2024.1441189,https://pubmed.ncbi.nlm.nih.gov/39323867/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGPD3,ENSG00000153165,Neither,37098512,The adaptive evolution of cancer driver genes.,2023,10.1186/s12864-023-09301-9,https://pubmed.ncbi.nlm.nih.gov/37098512/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGPD3,ENSG00000153165,Neither,30968251,Whole-exome sequencing identified four loci influencing craniofacial morphology in northern Han Chinese.,2019,10.1007/s00439-019-02008-6,https://pubmed.ncbi.nlm.nih.gov/30968251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGPD4,ENSG00000196862,Neither,36158696,Exome sequencing link mutation in RGPD4 with systemic sclerosis-associated interstitial lung disease and the low level of testosterone-an exploration study.,2022,10.3389/fonc.2022.956552,https://pubmed.ncbi.nlm.nih.gov/36158696/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGPD4,ENSG00000196862,Neither,38262548,Novel islands of GGC and GCC repeats coincide with human evolution.,2024,10.1016/j.gene.2024.148194,https://pubmed.ncbi.nlm.nih.gov/38262548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGPD4,ENSG00000196862,Neither,39557707,Genetic landscape of congenital pouch colon: systematic review and functional enrichment study.,2024,10.1007/s00383-024-05878-8,https://pubmed.ncbi.nlm.nih.gov/39557707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGPD4,ENSG00000196862,Neither,35701113,[Exploring the association between de novo mutations and non-syndromic cleft lip with or without palate based on whole exome sequencing of case-parent trios].,2022,10.19723/j.issn.1671-167x.2022.03.001,https://pubmed.ncbi.nlm.nih.gov/35701113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGPD4,ENSG00000196862,Neither,26117982,[Expression of melatonin receptors genes and genes associated with regulation of their activity in endometrial cancer].,2015,10.17772/gp/2069,https://pubmed.ncbi.nlm.nih.gov/26117982/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGPD4,ENSG00000196862,Neither,24467795,Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome.,2014,10.1186/2040-2392-5-4,https://pubmed.ncbi.nlm.nih.gov/24467795/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGPD4,ENSG00000196862,Neither,11501497,Detection of the retinoic acid-regulated genes in a RTBM1 neuroblastoma cell line using cDNA microarray.,2001,10.2739/kurumemedj.48.159,https://pubmed.ncbi.nlm.nih.gov/11501497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGSL1,ENSG00000121446,Neither,42051206,Hsa_Circ_0036763 is a Prognostic Biomarker for Intervertebral Disc Degeneration and Affects the Senescence and Collagen Loss of Nucleus Pulposus Cells via miR-4741/RGSL1.,2026,10.1080/08941939.2026.2656577,https://pubmed.ncbi.nlm.nih.gov/42051206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGSL1,ENSG00000121446,Neither,40389209,Exploring Sex Differences in Type 2 Diabetes via a Male-Dominant Beta-Cell Cluster from Single-Cell Pancreatic Sequencing of Public Datasets.,2025,10.3803/enm.2025.2297,https://pubmed.ncbi.nlm.nih.gov/40389209/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGSL1,ENSG00000121446,Neither,38540416,Whole-Exome Sequencing (WES) Reveals Novel Sex-Specific Gene Variants in Non-Alcoholic Steatohepatitis (MASH).,2024,10.3390/genes15030357,https://pubmed.ncbi.nlm.nih.gov/38540416/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGSL1,ENSG00000121446,Neither,34621245,Identification of mRNA Prognostic Markers for TGCT by Integration of Co-Expression and CeRNA Network.,2021,10.3389/fendo.2021.743155,https://pubmed.ncbi.nlm.nih.gov/34621245/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGSL1,ENSG00000121446,Neither,18521847,"A fragile site within the HPC1 region at 1q25.3 affecting RGS16, RGSL1, and RGSL2 in human breast carcinomas.",2008,10.1002/gcc.20578,https://pubmed.ncbi.nlm.nih.gov/18521847/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGSL1,ENSG00000121446,Neither,12801632,Identification of 9 novel transcripts and two RGSL genes within the hereditary prostate cancer region (HPC1) at 1q25.,2003,10.1016/s0378-1119(03)00501-8,https://pubmed.ncbi.nlm.nih.gov/12801632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGSL1,ENSG00000121446,Neither,23938467,Linking spermatid ribonucleic acid (RNA) binding protein and retrogene diversity to reproductive success.,2013,10.1074/mcp.m113.030585,https://pubmed.ncbi.nlm.nih.gov/23938467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGSL1,ENSG00000121446,Neither,28509457,[Urine proteome study for the evaluation of age dynamics in healthy men].,2015,,https://pubmed.ncbi.nlm.nih.gov/28509457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGSL1,ENSG00000121446,Neither,19460155,On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.,2009,10.1186/1472-6807-9-36,https://pubmed.ncbi.nlm.nih.gov/19460155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGSL1,ENSG00000121446,Neither,21816819,"Insights into the molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF.",2011,10.1074/jbc.m111.270918,https://pubmed.ncbi.nlm.nih.gov/21816819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGSL1,ENSG00000121446,Neither,11281715,"Expression, purification, and crystallization of the RGS-like domain from the Rho nucleotide exchange factor, PDZ-RhoGEF, using the surface entropy reduction approach.",2001,10.1006/prep.2001.1392,https://pubmed.ncbi.nlm.nih.gov/11281715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMBP3B,ENSG00000274600,Neither,42286492,Diversity of molecular karyotypes of 234 pediatric patients with autism spectrum disorder in chromosomal microarray analysis.,2026,10.1186/s12888-026-08263-y,https://pubmed.ncbi.nlm.nih.gov/42286492/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNASE11,ENSG00000173464,Neither,39476961,Epididymis-specific RNase A family genes regulate fertility and small RNA processing.,2024,10.1016/j.jbc.2024.107933,https://pubmed.ncbi.nlm.nih.gov/39476961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTL9,ENSG00000243978,Neither,42511665,Virus-Derived Domesticated Genes in Microglia and Resident Macrophages: Insights into Placenta-Driven Evolution in Mammals.,2026,10.3390/ijms27146322,https://pubmed.ncbi.nlm.nih.gov/42511665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTL9,ENSG00000243978,Neither,37834332,Retrovirus-Derived RTL9 Plays an Important Role in Innate Antifungal Immunity in the Eutherian Brain.,2023,10.3390/ijms241914884,https://pubmed.ncbi.nlm.nih.gov/37834332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTL9,ENSG00000243978,Neither,37892118,Retrovirus-Derived RTL/SIRH: Their Diverse Roles in the Current Eutherian Developmental System and Contribution to Eutherian Evolution.,2023,10.3390/biom13101436,https://pubmed.ncbi.nlm.nih.gov/37892118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTL9,ENSG00000243978,Neither,40228447,BCOR-rearranged sarcomas: In silico insights into altered domains and BCOR interactions.,2025,10.1016/j.compbiomed.2025.110144,https://pubmed.ncbi.nlm.nih.gov/40228447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTL9,ENSG00000243978,Neither,36765856,Molecular Identification and In Silico Protein Analysis of a Novel BCOR-CLGN Gene Fusion in Intrathoracic BCOR-Rearranged Sarcoma.,2023,10.3390/cancers15030898,https://pubmed.ncbi.nlm.nih.gov/36765856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTL9,ENSG00000243978,Neither,34331570,Novel RGAG1-BCOR gene fusion revealed in a somatic soft tissue sarcoma with a long follow-up.,2022,10.1007/s00428-021-03160-z,https://pubmed.ncbi.nlm.nih.gov/34331570/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTL9,ENSG00000243978,Neither,38688863,X-linked genetic associations in sporadic thoracic aortic dissection.,2024,10.1002/ajmg.a.63644,https://pubmed.ncbi.nlm.nih.gov/38688863/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTL9,ENSG00000243978,Neither,20051947,Genome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non-coding RNAs in human testicular cancer.,2010,10.1038/sj.bjc.6605505,https://pubmed.ncbi.nlm.nih.gov/20051947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTL9,ENSG00000243978,Neither,25888968,Selective expression of sense and antisense transcripts of the sushi-ichi-related retrotransposon--derived family during mouse placentogenesis.,2015,10.1186/s12977-015-0138-8,https://pubmed.ncbi.nlm.nih.gov/25888968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTL9,ENSG00000243978,Neither,32156473,"Genomic profiling of BCOR-rearranged uterine sarcomas reveals novel gene fusion partners, frequent CDK4 amplification and CDKN2A loss.",2020,10.1016/j.ygyno.2020.02.024,https://pubmed.ncbi.nlm.nih.gov/32156473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTL9,ENSG00000243978,Neither,26367797,The UK10K project identifies rare variants in health and disease.,2015,10.1038/nature14962,https://pubmed.ncbi.nlm.nih.gov/26367797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTP2,ENSG00000198471,Neither,41125435,Identifying Key Regulators in Odorant Receptor Trafficking.,2025,10.1523/jneurosci.0454-25.2025,https://pubmed.ncbi.nlm.nih.gov/41125435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTP2,ENSG00000198471,Neither,40841946,"Dynamic change of direction, isometric strength, and psychological readiness in final phase ACLR athletes: an integrated approach.",2025,10.1186/s12891-025-09002-2,https://pubmed.ncbi.nlm.nih.gov/40841946/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTP2,ENSG00000198471,Neither,37045891,"Reproducible Tract Profiles 2 (RTP2) suite, from diffusion MRI acquisition to clinical practice and research.",2023,10.1038/s41598-023-32924-7,https://pubmed.ncbi.nlm.nih.gov/37045891/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTP2,ENSG00000198471,Neither,28586385,Receptor-transporting protein (RTP) family members play divergent roles in the functional expression of odorant receptors.,2017,10.1371/journal.pone.0179067,https://pubmed.ncbi.nlm.nih.gov/28586385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTP2,ENSG00000198471,Neither,27458372,Olfactory Receptors in Non-Chemosensory Organs: The Nervous System in Health and Disease.,2016,10.3389/fnagi.2016.00163,https://pubmed.ncbi.nlm.nih.gov/27458372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTP2,ENSG00000198471,Neither,28262096,Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice.,2017,10.7554/elife.21895,https://pubmed.ncbi.nlm.nih.gov/28262096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTP2,ENSG00000198471,Neither,36543404,[Establishment of local allergic rhinitis tolerance in mouse model].,2022,10.13201/j.issn.2096-7993.2022.12.011,https://pubmed.ncbi.nlm.nih.gov/36543404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTP2,ENSG00000198471,Neither,23960453,Interfractional variation of radiation target and adaptive radiotherapy for totally resected glioblastoma.,2013,10.3346/jkms.2013.28.8.1233,https://pubmed.ncbi.nlm.nih.gov/23960453/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTP2,ENSG00000198471,Neither,20943918,REEP2 enhances sweet receptor function by recruitment to lipid rafts.,2010,10.1523/jneurosci.0091-10.2010,https://pubmed.ncbi.nlm.nih.gov/20943918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTP2,ENSG00000198471,Neither,15550249,RTP family members induce functional expression of mammalian odorant receptors.,2004,10.1016/j.cell.2004.11.021,https://pubmed.ncbi.nlm.nih.gov/15550249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTP2,ENSG00000198471,Neither,19686127,Trafficking of mammalian chemosensory receptors by receptor-transporting proteins.,2009,10.1111/j.1749-6632.2009.03888.x,https://pubmed.ncbi.nlm.nih.gov/19686127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTP2,ENSG00000198471,Neither,22760553,Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D.,2012,10.1038/tp.2012.57,https://pubmed.ncbi.nlm.nih.gov/22760553/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTP2,ENSG00000198471,Neither,16720576,Members of RTP and REEP gene families influence functional bitter taste receptor expression.,2006,10.1074/jbc.m513637200,https://pubmed.ncbi.nlm.nih.gov/16720576/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAXO5,ENSG00000198723,Neither,40649876,Age-Associated Proteomic Changes in Human Spermatozoa.,2025,10.3390/ijms26136099,https://pubmed.ncbi.nlm.nih.gov/40649876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAXO5,ENSG00000198723,Neither,40837069,Genome-Wide Association Study and Rare Variant Association Studies of Strabismus in the &lt;i&gt;All of Us&lt;/i&gt; Research Program.,2025,10.1016/j.xops.2025.100873,https://pubmed.ncbi.nlm.nih.gov/40837069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAXO5,ENSG00000198723,Neither,35884586,Differential Transcriptomic Profiles Following Stimulation with Lipopolysaccharide in Intestinal Organoids from Dogs with Inflammatory Bowel Disease and Intestinal Mast Cell Tumor.,2022,10.3390/cancers14143525,https://pubmed.ncbi.nlm.nih.gov/35884586/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAND3,ENSG00000232040,Neither,40972435,Characterizing the mutational landscape of sinonasal squamous cell carcinoma using whole-exome sequencing.,2025,10.1016/j.oraloncology.2025.107694,https://pubmed.ncbi.nlm.nih.gov/40972435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAND3,ENSG00000232040,Neither,41121288,DNA methylation profiles and cancer in children conceived after assisted reproductive technology.,2025,10.1186/s13148-025-01982-1,https://pubmed.ncbi.nlm.nih.gov/41121288/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAND3,ENSG00000232040,Neither,38687434,ZAP70: A Key Gene Identified by Differential Expression Analysis for Early Diagnosis of Fetuses with Emanuel Syndrome.,2025,10.1007/s10528-024-10808-3,https://pubmed.ncbi.nlm.nih.gov/38687434/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAND3,ENSG00000232040,Neither,32824823,Hypermethylation of SCAND3 and Myo1g Gene Are Potential Diagnostic Biomarkers for Hepatocellular Carcinoma.,2020,10.3390/cancers12082332,https://pubmed.ncbi.nlm.nih.gov/32824823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAND3,ENSG00000232040,Neither,38534411,Three Copies of zbed1 Specific in Chromosome W Are Essential for Female-Biased Sexual Size Dimorphism in Cynoglossus semilaevis.,2024,10.3390/biology13030141,https://pubmed.ncbi.nlm.nih.gov/38534411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAND3,ENSG00000232040,Neither,34083597,Genome-wide association study on blood pressure traits in the Iranian population suggests ZBED9 as a new locus for hypertension.,2021,10.1038/s41598-021-90925-w,https://pubmed.ncbi.nlm.nih.gov/34083597/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAND3,ENSG00000232040,Neither,28418919,ZNF452 facilitates tumor proliferation and invasion via activating AKT-GSK3β signaling pathway and predicts poor prognosis of non-small cell lung cancer patients.,2017,10.18632/oncotarget.16408,https://pubmed.ncbi.nlm.nih.gov/28418919/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAND3,ENSG00000232040,Neither,37686511,Whole Exome-Wide Association Identifies Rare Variants in GALNT9 Associated with Middle Eastern Papillary Thyroid Carcinoma Risk.,2023,10.3390/cancers15174235,https://pubmed.ncbi.nlm.nih.gov/37686511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAND3,ENSG00000232040,Neither,28493959,Novel genetic locus at MHC region for esophageal squamous cell carcinoma in Chinese populations.,2017,10.1371/journal.pone.0177494,https://pubmed.ncbi.nlm.nih.gov/28493959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAND3,ENSG00000232040,Neither,23550032,"On the transposon origins of mammalian SCAND3 and KRBA2, two zinc-finger genes carrying an integrase/transposase domain.",2012,10.4161/mge.22914,https://pubmed.ncbi.nlm.nih.gov/23550032/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAND3,ENSG00000232040,Neither,19527686,New TFII-I family target genes involved in embryonic development.,2009,10.1016/j.bbrc.2009.06.045,https://pubmed.ncbi.nlm.nih.gov/19527686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAND3,ENSG00000232040,Neither,23166581,Comparative analysis of the recently discovered hAT transposon TcBuster in human cells.,2012,10.1371/journal.pone.0042666,https://pubmed.ncbi.nlm.nih.gov/23166581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAND3,ENSG00000232040,Neither,35577038,The AGT epistasis pattern proposed a novel role for ZBED9 in regulating blood pressure: Tehran Cardiometabolic genetic study (TCGS).,2022,10.1016/j.gene.2022.146560,https://pubmed.ncbi.nlm.nih.gov/35577038/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,42638053,[Expression and immunogenicity of porcine deltacoronavirus S-trimer protein].,2026,10.13345/j.cjb.260066,https://pubmed.ncbi.nlm.nih.gov/42638053/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,40860858,The prevalence and severity of late postnatal anaemia amongst women at the Buea and Limbe Regional Hospitals in Cameroon.,2025,10.11604/pamj.2025.51.41.40494,https://pubmed.ncbi.nlm.nih.gov/40860858/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,31520888,Functional extracellular vesicles engineered with lipid-grafted hyaluronic acid effectively reverse cancer drug resistance.,2019,10.1016/j.biomaterials.2019.119475,https://pubmed.ncbi.nlm.nih.gov/31520888/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,34308038,"A Simulation Study of Water Injection Position and Pressure on the Knock, Combustion, and Emissions of a Direct Injection Gasoline Engine.",2021,10.1021/acsomega.1c01792,https://pubmed.ncbi.nlm.nih.gov/34308038/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,18304778,A conserved and immunodominant lipoprotein of Francisella tularensis is proinflammatory but not essential for virulence.,2008,10.1016/j.micpath.2008.01.003,https://pubmed.ncbi.nlm.nih.gov/18304778/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,24098675,Alterations in the Helicoverpa armigera midgut digestive physiology after ingestion of pigeon pea inducible leucine aminopeptidase.,2013,10.1371/journal.pone.0074889,https://pubmed.ncbi.nlm.nih.gov/24098675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,21385388,"The cytokine-driven regulation of secretoglobins in normal human upper airway and their expression, particularly that of uteroglobin-related protein 1, in chronic rhinosinusitis.",2011,10.1186/1465-9921-12-28,https://pubmed.ncbi.nlm.nih.gov/21385388/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,21529386,"Transstadial transmission of Francisella tularensis holarctica in mosquitoes, Sweden.",2011,10.3201/eid1705.100426,https://pubmed.ncbi.nlm.nih.gov/21529386/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,21167291,Purification and partial characterization of an aminopeptidase from the midgut tissue of Dysdercus peruvianus.,2011,10.1016/j.cbpb.2010.12.002,https://pubmed.ncbi.nlm.nih.gov/21167291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,20885922,Molecular Detection of Persistent Francisella tularensis Subspecies holarctica in Natural Waters.,2011,10.1155/2011/851946,https://pubmed.ncbi.nlm.nih.gov/20885922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,25755189,Revisiting the Gram-negative lipoprotein paradigm.,2015,10.1128/jb.02414-14,https://pubmed.ncbi.nlm.nih.gov/25755189/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,29018123,Characterization of Inner and Outer Membrane Proteins from Francisella tularensis Strains LVS and Schu S4 and Identification of Potential Subunit Vaccine Candidates.,2017,10.1128/mbio.01592-17,https://pubmed.ncbi.nlm.nih.gov/29018123/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,19176692,"Francisella tularensis infection-derived monoclonal antibodies provide detection, protection, and therapy.",2009,10.1128/cvi.00362-08,https://pubmed.ncbi.nlm.nih.gov/19176692/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,2594690,Buccal absorption. III. Simultaneous diffusion and metabolism of an aminopeptidase substrate in the hamster cheek pouch.,1989,10.1023/a:1015949614437,https://pubmed.ncbi.nlm.nih.gov/2594690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,12355581,Bioequivalence evaluation of two brands of metformin 500 mg tablets (Dialon & Glucophage)--in healthy human volunteers.,2002,10.1002/bdd.326,https://pubmed.ncbi.nlm.nih.gov/12355581/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,10442505,Bioequivalence of a generic metformin tablet preparation.,1999,,https://pubmed.ncbi.nlm.nih.gov/10442505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,35726496,Targeted nanotherapy with everolimus reduces inflammation and fibrosis in scleroderma-related interstitial lung disease developed by PSGL-1 deficient mice.,2022,10.1111/bph.15898,https://pubmed.ncbi.nlm.nih.gov/35726496/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,32092961,Sorption of CO2 and CH4 on Raw and Calcined Halloysite-Structural and Pore Characterization Study.,2020,10.3390/ma13040917,https://pubmed.ncbi.nlm.nih.gov/32092961/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,22163782,Photonic biosensor assays to detect and distinguish subspecies of Francisella tularensis.,2011,10.3390/s110303004,https://pubmed.ncbi.nlm.nih.gov/22163782/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,8577211,Influence of food on the disposition of the antidiabetic drug metformin in diabetic patients at steady-state.,1995,,https://pubmed.ncbi.nlm.nih.gov/8577211/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCGB1D1,ENSG00000168515,Neither,8457711,Flavone acetic acid--from laboratory to clinic and back.,1993,10.1097/00001813-199302000-00001,https://pubmed.ncbi.nlm.nih.gov/8457711/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,42231021,Microbial reactivation of host androgens directs enteric neuronal regulation of gut motility.,2026,10.1038/s41593-026-02321-0,https://pubmed.ncbi.nlm.nih.gov/42231021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,40630435,Voltage-Gated Sodium Channels: A Therapeutic Target in Ischemic Heart Disease.,2025,10.31083/rcm27140,https://pubmed.ncbi.nlm.nih.gov/40630435/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,41462261,NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons.,2025,10.1186/s12974-025-03675-1,https://pubmed.ncbi.nlm.nih.gov/41462261/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,42156780,Gene-gene interactions between a LMNA variant and common polymorphisms drive early-onset atrial fibrillation.,2026,10.1038/s41467-026-73113-0,https://pubmed.ncbi.nlm.nih.gov/42156780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,42467787,A neurocutaneous Na&lt;sub&gt;V&lt;/sub&gt;1.8 channelopathy underlies a genetic subtype of primary idiopathic hyperhidrosis.,2026,10.1126/sciadv.aed3221,https://pubmed.ncbi.nlm.nih.gov/42467787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,41141708,Integrated Genomic Approaches to Elucidate the Genetic Basis of Brugada Syndrome in Taiwanese Patients.,2025,10.1177/11779322251385926,https://pubmed.ncbi.nlm.nih.gov/41141708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,42510583,"Omega-3 Fatty Acids Attenuate Neuropathic Pain by Modulating Ferroptotic Stress, Selenoamino Acid Metabolism, and Lipid Remodeling.",2026,10.3390/antiox15070852,https://pubmed.ncbi.nlm.nih.gov/42510583/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,42381253,Heart-Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes.,2026,10.1002/cph4.70203,https://pubmed.ncbi.nlm.nih.gov/42381253/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,42292832,Mechanistic prediction of angelicae pubescentis radix in preventing arrhythmia via modulation of calcium channel targets: an integrated network pharmacology and target enrichment analysis.,2026,10.3389/fphar.2026.1778679,https://pubmed.ncbi.nlm.nih.gov/42292832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,41327470,Phenotypes in Brugada syndrome with different genotypes triggered by fever or inflammation using gene-edited iPSCs.,2025,10.1186/s13287-025-04793-6,https://pubmed.ncbi.nlm.nih.gov/41327470/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,42291549,Genetics of supraventricular tachycardia: current evidence with a focus on translational relevance and personalized medicine.,2026,10.3389/fcvm.2026.1832643,https://pubmed.ncbi.nlm.nih.gov/42291549/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,40592989,Identification and validation of key target genes of penning formula for treating rat chronic endometritis model.,2025,10.1038/s41598-025-02585-9,https://pubmed.ncbi.nlm.nih.gov/40592989/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,42092729,Comprehensive Pathologic and Genetic Investigation of Four Young Adults with a Short QT Interval and Sudden Unexpected Death.,2026,10.1016/j.jmoldx.2026.04.004,https://pubmed.ncbi.nlm.nih.gov/42092729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,42909906,"Na&lt;sub&gt;V&lt;/sub&gt;1.7, 1.8 and 1.9 mutations linked to painful channelopathies have no pain phenotype in UK Biobank.",2026,10.1093/braincomms/fcag374,https://pubmed.ncbi.nlm.nih.gov/42909906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,41541644,Genomic Structural Equation Modeling Combined With Post-GWAS Analysis Identifies Two Risk Gene Loci and Functionally Sensitive Genes Associated With Cardiac Conduction Block.,2026,10.1155/genr/1063531,https://pubmed.ncbi.nlm.nih.gov/41541644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,41865132,"Autism spectrum disorder trios from consanguineous populations are enriched for rare homozygous variants, identifying 32 new candidate genes.",2026,10.1038/s41598-026-44288-9,https://pubmed.ncbi.nlm.nih.gov/41865132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,42123485,Type 1 Brugada Pattern Triggered by Low-Grade Fever: Implications for Diagnosis and Risk Stratification.,2026,10.3390/ijms27093900,https://pubmed.ncbi.nlm.nih.gov/42123485/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,39973098,SCN10A-short gene therapy to restore conduction and protect against malignant cardiac arrhythmias.,2025,10.1093/eurheartj/ehaf053,https://pubmed.ncbi.nlm.nih.gov/39973098/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,39808573,mRNA Expression of Mineralocorticoid and Glucocorticoid Receptors in Human and Mouse Sensory Neurons of the Dorsal Root Ganglia.,2025,10.1213/ane.0000000000007133,https://pubmed.ncbi.nlm.nih.gov/39808573/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,41564389,Whole-exome sequencing in obstructive coronary artery disease identifies rare and novel variants in cardiac arrhythmia and pulmonary arterial hypertension-associated genes.,2026,10.17305/bb.2026.13200,https://pubmed.ncbi.nlm.nih.gov/41564389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,42321904,Association between voltage-gated sodium channel gene polymorphisms and chronic oxaliplatin-induced peripheral neuropathy in Japanese patients with colorectal cancer.,2026,10.1186/s40780-026-00601-2,https://pubmed.ncbi.nlm.nih.gov/42321904/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,42530450,Exploring GC-MS-Based Phytochemistry and Network Pharmacology to Elucidate the Multi-Target Therapeutic Potential of Betel Leaf Oil as an Analgesic and Anti-Inflammatory Agent.,2026,10.1002/bmc.70564,https://pubmed.ncbi.nlm.nih.gov/42530450/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,39825384,SCN10A gene polymorphism is associated with pain sensitivity and postoperative analgesic effects in patients undergoing gynecological laparoscopy.,2025,10.1186/s40001-025-02284-1,https://pubmed.ncbi.nlm.nih.gov/39825384/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,40427587,Nav1.8 and Chronic Pain: From Laboratory Animals to Clinical Patients.,2025,10.3390/biom15050694,https://pubmed.ncbi.nlm.nih.gov/40427587/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,38999942,"Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial Episodic Pain Syndrome (FEPS) in Japan and Proposal of Clinical Diagnostic Criteria.",2024,10.3390/ijms25136832,https://pubmed.ncbi.nlm.nih.gov/38999942/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,38892333,NaV1.8 as Proarrhythmic Target in a Ventricular Cardiac Stem Cell Model.,2024,10.3390/ijms25116144,https://pubmed.ncbi.nlm.nih.gov/38892333/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,38755266,Prediction models of persistent taxane-induced peripheral neuropathy among breast cancer survivors using whole-exome sequencing.,2024,10.1038/s41698-024-00594-x,https://pubmed.ncbi.nlm.nih.gov/38755266/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,37373335,Molecular and Functional Relevance of NaV1.8-Induced Atrial Arrhythmogenic Triggers in a Human SCN10A Knock-Out Stem Cell Model.,2023,10.3390/ijms241210189,https://pubmed.ncbi.nlm.nih.gov/37373335/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,40019402,Regulation of PVT-CeA Circuit in Deoxynivalenol-Induced Anorexia and Aversive-Like Emotions.,2025,10.1002/advs.202417068,https://pubmed.ncbi.nlm.nih.gov/40019402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,39433284,The Evolving Landscape of Small Fiber Neuropathy.,2025,10.1055/s-0044-1791823,https://pubmed.ncbi.nlm.nih.gov/39433284/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,36140801,Biallelic Loss of Function Mutation in Sodium Channel Gene &lt;i&gt;SCN10A&lt;/i&gt; in an Autism Spectrum Disorder Trio from Pakistan.,2022,10.3390/genes13091633,https://pubmed.ncbi.nlm.nih.gov/36140801/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,41752838,Alteplase and Angioedema: Can Clinical Exome Sequencing Redefine the Paradigm?,2026,10.3390/life16020200,https://pubmed.ncbi.nlm.nih.gov/41752838/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCN10A,ENSG00000185313,Neither,9839820,"A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A.",1998,10.1016/s0304-3959(98)00120-1,https://pubmed.ncbi.nlm.nih.gov/9839820/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SERPINA2,ENSG00000258597,Neither,40486681,Distinct germ-line genetic mutation patterns correlate with reproductive outcomes in ICSI patients: a pilot study.,2025,10.3389/fgene.2025.1610943,https://pubmed.ncbi.nlm.nih.gov/40486681/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SERPINA2,ENSG00000258597,Neither,23826168,SERPINA2 is a novel gene with a divergent function from SERPINA1.,2013,10.1371/journal.pone.0066889,https://pubmed.ncbi.nlm.nih.gov/23826168/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIDA1,ENSG00000180592,Neither,42399771,Integrating WGCNA and machine learning to identify and validate key biomarkers in MASLD.,2026,10.1186/s12876-026-05071-2,https://pubmed.ncbi.nlm.nih.gov/42399771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIDA1,ENSG00000180592,Neither,41574310,SKIDA1 sustains MLL::ENL-expressing hematopoietic progenitors during neonatal stages and promotes B-lineage priming.,2026,10.1016/j.bneo.2025.100185,https://pubmed.ncbi.nlm.nih.gov/41574310/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIDA1,ENSG00000180592,Neither,41751625,Regulatory Potential of piRNAs Targeting &lt;i&gt;Klotho&lt;/i&gt; and Other Genes.,2026,10.3390/genes17020241,https://pubmed.ncbi.nlm.nih.gov/41751625/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIDA1,ENSG00000180592,Neither,40884014,A characteristic gene expression profile regulated by ACIN1::NUTM1 fusion in a newly identified infant leukaemic cell line and an ACIN1::NUTM1-inducible model.,2025,10.1111/bjh.70130,https://pubmed.ncbi.nlm.nih.gov/40884014/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIDA1,ENSG00000180592,Neither,40361241,Insights into KMT2A rearrangements in acute myeloid leukemia: from molecular characteristics to targeted therapies.,2025,10.1186/s40364-025-00786-y,https://pubmed.ncbi.nlm.nih.gov/40361241/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIDA1,ENSG00000180592,Neither,40415527,Uncovering covariance patterns across energy balance traits enables the discovery of new obesity-related genes.,2025,10.1002/oby.24291,https://pubmed.ncbi.nlm.nih.gov/40415527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIDA1,ENSG00000180592,Neither,34526996,Transcriptional Changes in Regulatory T Cells From Patients With Autoimmune Polyendocrine Syndrome Type 1 Suggest Functional Impairment of Lipid Metabolism and Gut Homing.,2021,10.3389/fimmu.2021.722860,https://pubmed.ncbi.nlm.nih.gov/34526996/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIDA1,ENSG00000180592,Neither,35734412,Novel Diagnostic and Therapeutic Options for &lt;i&gt;KMT2A&lt;/i&gt;-Rearranged Acute Leukemias.,2022,10.3389/fphar.2022.749472,https://pubmed.ncbi.nlm.nih.gov/35734412/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIDA1,ENSG00000180592,Neither,29317232,The pore-forming protein Aep1 is an innate immune molecule that prevents zebrafish from bacterial infection.,2018,10.1016/j.dci.2018.01.003,https://pubmed.ncbi.nlm.nih.gov/29317232/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIDA1,ENSG00000180592,Neither,26711430,Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein.,2016,10.15252/embr.201540851,https://pubmed.ncbi.nlm.nih.gov/26711430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIDA1,ENSG00000180592,Neither,35299049,A novel Bacillus cereus bacteriophage DLn1 and its endolysin as biocontrol agents against Bacillus cereus in milk.,2022,10.1016/j.ijfoodmicro.2022.109615,https://pubmed.ncbi.nlm.nih.gov/35299049/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,41821366,"Biallelic Novel SKOR2 Variants in Individuals With Cerebellar Hypoplasia and Intellectual Disability, Expanding the Phenotypic Spectrum of Valence-Farazi Cerebellar Ataxia Syndrome.",2026,10.1002/ajmg.a.70125,https://pubmed.ncbi.nlm.nih.gov/41821366/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,40890458,Identification of two novel pathogenic mutations in the SKOR2 gene linked to cerebellar hypoplasia and a broad spectrum of neurodevelopmental delay in two Iranian families.,2025,10.1038/s10038-025-01399-x,https://pubmed.ncbi.nlm.nih.gov/40890458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,37795104,Identification of SKOR2 IgG as a novel biomarker of paraneoplastic neurologic syndrome.,2023,10.3389/fimmu.2023.1243946,https://pubmed.ncbi.nlm.nih.gov/37795104/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,41933071,Ythdf2/Setd1b regulatory axis is essential for cerebellar development through regulating epigenetic reprogramming.,2026,10.1038/s41380-026-03580-w,https://pubmed.ncbi.nlm.nih.gov/41933071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,38456494,Foxp and Skor family proteins control differentiation of Purkinje cells from Ptf1a- and Neurog1-expressing progenitors in zebrafish.,2024,10.1242/dev.202546,https://pubmed.ncbi.nlm.nih.gov/38456494/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,40188079,"Interactions among Merlin, Arkadia, and SKOR2 mediate NF2-associated human Schwann cell proliferation.",2025,10.1186/s13287-025-04281-x,https://pubmed.ncbi.nlm.nih.gov/40188079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,35815619,"Gata2, Nkx2-2 and Skor2 form a transcription factor network regulating development of a midbrain GABAergic neuron subtype with characteristics of REM-sleep regulatory neurons.",2022,10.1242/dev.200937,https://pubmed.ncbi.nlm.nih.gov/35815619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,35030229,"The Drosophila functional Smad suppressing element fuss, a homologue of the human Skor genes, retains pro-oncogenic properties of the Ski/Sno family.",2022,10.1371/journal.pone.0262360,https://pubmed.ncbi.nlm.nih.gov/35030229/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,24491816,The c-Ski family member and transcriptional regulator Corl2/Skor2 promotes early differentiation of cerebellar Purkinje cells.,2014,10.1016/j.ydbio.2014.01.016,https://pubmed.ncbi.nlm.nih.gov/24491816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,31291246,Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing.,2019,10.1371/journal.pone.0213702,https://pubmed.ncbi.nlm.nih.gov/31291246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,34912705,Precise Identification of Recurrent Somatic Mutations in Oral Cancer Through Whole-Exome Sequencing Using Multiple Mutation Calling Pipelines.,2021,10.3389/fonc.2021.741626,https://pubmed.ncbi.nlm.nih.gov/34912705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,32292414,Genome-Wide Association Study and Fine Mapping Reveals Candidate Genes for Birth Weight of Yorkshire and Landrace Pigs.,2020,10.3389/fgene.2020.00183,https://pubmed.ncbi.nlm.nih.gov/32292414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,24337411,Validation of nucleolar protein 4 as a novel methylated tumor suppressor gene in head and neck cancer.,2014,10.3892/or.2013.2927,https://pubmed.ncbi.nlm.nih.gov/24337411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,34387844,Carbonic Anhydrase III Attenuates Hypoxia-Induced Apoptosis and Activates PI3K/Akt/mTOR Pathway in H9c2 Cardiomyocyte Cell Line.,2021,10.1007/s12012-021-09683-w,https://pubmed.ncbi.nlm.nih.gov/34387844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,29397531,A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells.,2018,10.1007/s12311-017-0913-2,https://pubmed.ncbi.nlm.nih.gov/29397531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,32514046,DNA methylation markers panel can improve prediction of response to neoadjuvant chemotherapy in luminal B breast cancer.,2020,10.1038/s41598-020-66197-1,https://pubmed.ncbi.nlm.nih.gov/32514046/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,21937600,Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development.,2011,10.1242/dev.067264,https://pubmed.ncbi.nlm.nih.gov/21937600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,32161085,Adult Movement Defects Associated with a CORL Mutation in Drosophila Display Behavioral Plasticity.,2020,10.1534/g3.120.400648,https://pubmed.ncbi.nlm.nih.gov/32161085/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,18522874,"Identification of a novel transcriptional corepressor, Corl2, as a cerebellar Purkinje cell-selective marker.",2008,10.1016/j.gep.2008.04.004,https://pubmed.ncbi.nlm.nih.gov/18522874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,34417961,Preliminary study of genome-wide association identifies novel susceptibility genes for serum mineral elements in the Chinese Han population.,2022,10.1007/s12011-021-02854-4,https://pubmed.ncbi.nlm.nih.gov/34417961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,30598658,The plasma peptides of ovarian cancer.,2018,10.1186/s12014-018-9215-z,https://pubmed.ncbi.nlm.nih.gov/30598658/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKOR2,ENSG00000215474,Neither,16200078,"Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues.",2005,10.1038/labinvest.3700344,https://pubmed.ncbi.nlm.nih.gov/16200078/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,42462966,The Role of SLC24A5 (NCKX5) in Human Skin Pigmentation: The Importance of Cation Transport Activity.,2026,10.1016/j.jmb.2026.169947,https://pubmed.ncbi.nlm.nih.gov/42462966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,42654211,Maternal Excessive Lard Versus Palm Oil Intake in Mice Drives Sex-Specific Reproductive Dysfunction in Offspring.,2026,10.3390/nu18162631,https://pubmed.ncbi.nlm.nih.gov/42654211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,42514693,A Study on the Effect of Copper Methionine in Alleviating Yellowing in Channel Catfish.,2026,10.3390/vetsci13070683,https://pubmed.ncbi.nlm.nih.gov/42514693/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,41183498,Candidate genes underlying hypomelanistic morphs in squamate reptiles.,2026,10.1093/genetics/iyaf236,https://pubmed.ncbi.nlm.nih.gov/41183498/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,39693635,Palmitoylation and regulation of potassium-dependent sodium/calcium exchangers (NCKX).,2025,10.1042/bsr20241051,https://pubmed.ncbi.nlm.nih.gov/39693635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,42651970,Histological and Strand-Specific Transcriptomic Analyses Reveal Developmental Dynamics and Pigmentation-Associated Candidate Genes in Black and White Skin Regions of Bama Miniature Pigs.,2026,10.3390/ani16162565,https://pubmed.ncbi.nlm.nih.gov/42651970/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,42276590,Genomic and transcriptomic analyses reveal the adaptation to semi-aquatic and aquatic life in spiders.,2026,10.1093/molbev/msag148,https://pubmed.ncbi.nlm.nih.gov/42276590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,39895901,A Nonsynonymous Single-nucleotide Polymorphism in SLC24A5 Regulates Feather Pigment Deposition in Chinese Yellow Quail.,2025,10.2141/jpsa.2025006,https://pubmed.ncbi.nlm.nih.gov/39895901/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,42565097,The genetic architecture of human skin pigmentation: evolution and adaptation across global populations.,2026,10.3389/fgene.2026.1870791,https://pubmed.ncbi.nlm.nih.gov/42565097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,42545527,A Reproducible Electroporation Strategy for CRISPR-Cas9 RNP and mRNA Delivery in Fish Embryos.,2026,10.1007/s10126-026-10682-7,https://pubmed.ncbi.nlm.nih.gov/42545527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,34870899,Impact of a SLC24A5 variant on the retinal pigment epithelium of a Japanese patient with oculocutaneous albinism type 6.,2022,10.1111/pcmr.13024,https://pubmed.ncbi.nlm.nih.gov/34870899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,40906177,The Genetics and Evolution of Human Pigmentation.,2025,10.3390/biology14081026,https://pubmed.ncbi.nlm.nih.gov/40906177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,38970414,Expression patterns of melanin-related genes are linked to crypsis and conspicuousness in a pumpkin toadlet.,2025,10.1111/mec.17458,https://pubmed.ncbi.nlm.nih.gov/38970414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,39940926,"Association of Genetic Polymorphisms in SLC45A2, TYR, HERC2, and SLC24A in African Women with Melasma: A Pilot Study.",2025,10.3390/ijms26031158,https://pubmed.ncbi.nlm.nih.gov/39940926/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,41103068,An Integrated Investigation of SOX10 in Feather Color in Domestic Rock Pigeon (Columba livia).,2025,10.1111/pcmr.70061,https://pubmed.ncbi.nlm.nih.gov/41103068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,28692664,A functional approach to understanding the role of NCKX5 in Xenopus pigmentation.,2017,10.1371/journal.pone.0180465,https://pubmed.ncbi.nlm.nih.gov/28692664/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,39937323,Dynamic Chromatin Accessibility and Transcriptional Regulation in the Eyes of Red Tilapia (Oreochromis sp.) in Response to Wintering Stress.,2025,10.1007/s10126-025-10424-1,https://pubmed.ncbi.nlm.nih.gov/39937323/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,39857428,DNA Methylation and Transcriptome Profiling Reveal the Role of the Antioxidant Pathway and Lipid Metabolism in &lt;i&gt;Plectropomus leopardus&lt;/i&gt; Skin Color Formation.,2025,10.3390/antiox14010093,https://pubmed.ncbi.nlm.nih.gov/39857428/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,37397501,"In silico analysis of the solute carrier (SLC) family in cancer indicates a link among DNA methylation, metabolic adaptation, drug response, and immune reactivity.",2023,10.3389/fphar.2023.1191262,https://pubmed.ncbi.nlm.nih.gov/37397501/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,31201282,Mitochondrial NCKX5 regulates melanosomal biogenesis and pigment production.,2019,10.1242/jcs.232009,https://pubmed.ncbi.nlm.nih.gov/31201282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,39259488,Transcriptome-based screening and validation of key genes for wool color in cashmere goats.,2024,10.1007/s13258-024-01562-2,https://pubmed.ncbi.nlm.nih.gov/39259488/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,32274888,Molecular characterization of SLC24A5 variants and evaluation of Nitisinone treatment efficacy in a zebrafish model of OCA6.,2020,10.1111/pcmr.12879,https://pubmed.ncbi.nlm.nih.gov/32274888/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,36429246,Integrated Analysis of Long Non-Coding RNA and mRNA to Reveal Putative Candidate Genes Associated with Backfat Quality in Beijing Black Pig.,2022,10.3390/foods11223654,https://pubmed.ncbi.nlm.nih.gov/36429246/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,32629302,"Evaluation of hypopigmentation in embryonic zebrafish induced by emerging disinfection byproduct, 3, 5-di-I-tyrosylalanine.",2020,10.1016/j.aquatox.2020.105525,https://pubmed.ncbi.nlm.nih.gov/32629302/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,35861041,Clinical and molecular change induced by repeated low-dose visible light exposure in both light-skinned and dark-skinned individuals.,2023,10.1111/phpp.12819,https://pubmed.ncbi.nlm.nih.gov/35861041/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,32443864,Characterization of POU2F1 Gene and Its Potential Impact on the Expression of Genes Involved in Fur Color Formation in Rex Rabbit.,2020,10.3390/genes11050575,https://pubmed.ncbi.nlm.nih.gov/32443864/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,32966289,Germline and somatic albinism variants in amelanotic/hypomelanotic melanoma: Increased carriage of TYR and OCA2 variants.,2020,10.1371/journal.pone.0238529,https://pubmed.ncbi.nlm.nih.gov/32966289/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,25370040,Novel genomic signals of recent selection in an Ethiopian population.,2015,10.1038/ejhg.2014.233,https://pubmed.ncbi.nlm.nih.gov/25370040/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,23071798,Functional assessment of human coding mutations affecting skin pigmentation using zebrafish.,2012,10.1371/journal.pone.0047398,https://pubmed.ncbi.nlm.nih.gov/23071798/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A5,ENSG00000188467,Neither,19384953,"Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians.",2009,10.1002/ijc.24327,https://pubmed.ncbi.nlm.nih.gov/19384953/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,40304571,DNA replication in primary hepatocytes without the six-subunit ORC.,2025,10.7554/elife.102915,https://pubmed.ncbi.nlm.nih.gov/40304571/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,40253531,"Integrative bioinformatics analysis reveals STAT1, ORC2, and GTF2B as critical biomarkers in lupus nephritis with Monkeypox virus infection.",2025,10.1038/s41598-025-97791-w,https://pubmed.ncbi.nlm.nih.gov/40253531/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,40504688,Regulation of epigenetics and chromosome structure by human ORC2.,2025,10.1016/j.celrep.2025.115816,https://pubmed.ncbi.nlm.nih.gov/40504688/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,42486479,CDK12 mediates the inhibition effect of mechanical unloading on osteoblast proliferation by regulating RNAPII transcription activation.,2026,10.1302/2046-3758.157.bjr-2025-0343.r1,https://pubmed.ncbi.nlm.nih.gov/42486479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,41258386,High ORC6 expression is a prognostic indicator of poor survival in glioma patients.,2025,10.1038/s41598-025-24630-3,https://pubmed.ncbi.nlm.nih.gov/41258386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,42427447,CRISPR-PITA: An Imaging-Based CRISPR/dCas9 Assay to Determine Recruitment Directionality of Nuclear Proteins.,2026,10.21769/bioprotoc.5742,https://pubmed.ncbi.nlm.nih.gov/42427447/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,41580178,CDC6 promotes keratinocyte senescence through the CCND1/P53 signaling in ischemia-reperfusion injury-induced pressure injury.,2026,10.1016/j.yexcr.2026.114903,https://pubmed.ncbi.nlm.nih.gov/41580178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,40316534,Anlotinib enhances the efficacy of KRAS-G12C inhibitors through c-Myc/ORC2 axis inhibition in non-small cell lung cancer.,2025,10.1038/s41419-025-07687-w,https://pubmed.ncbi.nlm.nih.gov/40316534/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,38288445,The ORFIUS complex regulates ORC2 localization at replication origins.,2024,10.1093/narcan/zcae003,https://pubmed.ncbi.nlm.nih.gov/38288445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,39271725,Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex.,2024,10.1038/s41467-024-52408-0,https://pubmed.ncbi.nlm.nih.gov/39271725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,40658797,A Trade-Off between Body Mass and Cancer Resistance in Cetaceans Is Mediated by Cell Cycle-Related Gene Evolution.,2025,10.1093/molbev/msaf159,https://pubmed.ncbi.nlm.nih.gov/40658797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,40530691,Specific origin selection and excess functional MCM2-7 loading in ORC-deficient cells.,2025,10.1093/nar/gkaf518,https://pubmed.ncbi.nlm.nih.gov/40530691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,34290169,CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice.,2022,10.4103/aja.aja_63_21,https://pubmed.ncbi.nlm.nih.gov/34290169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,41365064,"Design, synthesis and molecular docking of Pyrazolo[3,4-b]pyridine derivatives as potential CDK2 pathway inhibitors in colorectal cancer cells.",2026,10.1016/j.bioorg.2025.109335,https://pubmed.ncbi.nlm.nih.gov/41365064/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,37965896,The nucleolar protein GNL3 prevents resection of stalled replication forks.,2023,10.15252/embr.202357585,https://pubmed.ncbi.nlm.nih.gov/37965896/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,40063648,Unidirectional recruitment between MeCP2 and KSHV-encoded LANA revealed by CRISPR/Cas9 recruitment assay.,2025,10.1371/journal.ppat.1012972,https://pubmed.ncbi.nlm.nih.gov/40063648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,36351393,Nucleoporins facilitate ORC loading onto chromatin.,2022,10.1016/j.celrep.2022.111590,https://pubmed.ncbi.nlm.nih.gov/36351393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,37456470,In Silico Characterization of RNASEH2A Pathogenic Variants and Identification of Novel Splice Site Donor Variant c.549+1G>T in Indian Population.,2023,10.7759/cureus.40366,https://pubmed.ncbi.nlm.nih.gov/37456470/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,40588661,Cell cycle regulation has shaped replication origins in budding yeast.,2025,10.1038/s41594-025-01591-9,https://pubmed.ncbi.nlm.nih.gov/40588661/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,32989049,A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins.,2020,10.1074/jbc.ra120.015450,https://pubmed.ncbi.nlm.nih.gov/32989049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,33522487,"The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure.",2021,10.7554/elife.61797,https://pubmed.ncbi.nlm.nih.gov/33522487/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,36205357,Systemic analysis of the DNA replication regulator origin recognition complex in lung adenocarcinomas identifies prognostic and expression significance.,2023,10.1002/cam4.5238,https://pubmed.ncbi.nlm.nih.gov/36205357/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,34806016,"NAD&lt;sup&gt;+&lt;/sup&gt; bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells.",2021,10.1093/narcan/zcab044,https://pubmed.ncbi.nlm.nih.gov/34806016/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,30977266,Hyperammonemia after capecitabine associated with occult impairment of the urea cycle.,2019,10.1002/cam4.2036,https://pubmed.ncbi.nlm.nih.gov/30977266/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,32903837,Integrated PPI- and WGCNA-Retrieval of Hub Gene Signatures Shared Between Barrett's Esophagus and Esophageal Adenocarcinoma.,2020,10.3389/fphar.2020.00881,https://pubmed.ncbi.nlm.nih.gov/32903837/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,17267692,Roles of the CDK phosphorylation sites of yeast Cdc6 in chromatin binding and rereplication.,2007,10.1091/mbc.e06-06-0544,https://pubmed.ncbi.nlm.nih.gov/17267692/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,12808023,Drosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensation.,2003,10.1091/mbc.e02-11-0706,https://pubmed.ncbi.nlm.nih.gov/12808023/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,16537645,"Ubiquitylation, phosphorylation and Orc2 modulate the subcellular location of Orc1 and prevent it from inducing apoptosis.",2006,10.1242/jcs.02851,https://pubmed.ncbi.nlm.nih.gov/16537645/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,16322558,Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells.,2005,10.1101/gad.1369805,https://pubmed.ncbi.nlm.nih.gov/16322558/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,7579692,"The origin recognition complex in silencing, cell cycle progression, and DNA replication.",1995,10.1091/mbc.6.6.741,https://pubmed.ncbi.nlm.nih.gov/7579692/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,11486016,Control of DNA rereplication via Cdc2 phosphorylation sites in the origin recognition complex.,2001,10.1128/mcb.21.17.5767-5777.2001,https://pubmed.ncbi.nlm.nih.gov/11486016/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A2,ENSG00000120329,Neither,12807890,"The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms.",2003,10.1074/jbc.m302317200,https://pubmed.ncbi.nlm.nih.gov/12807890/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A52,ENSG00000141437,Neither,32906142,SLC25A51 is a mammalian mitochondrial NAD+ transporter.,2020,10.1038/s41586-020-2741-7,https://pubmed.ncbi.nlm.nih.gov/32906142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A52,ENSG00000141437,Neither,25743335,Whole-genome sequence-based analysis of thyroid function.,2015,10.1038/ncomms6681,https://pubmed.ncbi.nlm.nih.gov/25743335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A52,ENSG00000141437,Neither,24080446,Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study.,2013,10.1530/erc-13-0349,https://pubmed.ncbi.nlm.nih.gov/24080446/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,42034306,⍺TAT1-dependent microtubule acetylation is required for touch sensation in zebrafish but not for cilia-driven morphogenesis.,2026,10.1016/j.ydbio.2026.04.012,https://pubmed.ncbi.nlm.nih.gov/42034306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,42372917,Epigenetic silencing of miR-141 via core promoter methylation is associated with short-term bladder cancer progression.,2026,10.1016/j.jbc.2026.113302,https://pubmed.ncbi.nlm.nih.gov/42372917/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,42101182,Expression of sulfate pathway genes in human neurodevelopment.,2026,10.1080/01677063.2026.2649162,https://pubmed.ncbi.nlm.nih.gov/42101182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,40810050,Exploration of shared biomarkers and mechanisms in systemic lupus erythematous and lung cancer via bioinformatics analysis.,2025,10.1016/j.jtauto.2025.100304,https://pubmed.ncbi.nlm.nih.gov/40810050/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,38978230,The role of SLC26A8 homozygous variants in male infertility and flagellum abnormalities.,2024,10.4103/aja202421,https://pubmed.ncbi.nlm.nih.gov/38978230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,38927088,pH Homeodynamics and Male Fertility: A Coordinated Regulation of Acid-Based Balance during Sperm Journey to Fertilization.,2024,10.3390/biom14060685,https://pubmed.ncbi.nlm.nih.gov/38927088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,40725492,Diversity and Correlation Analysis of Differential Amino Acid Metabolites and Dominant Endophytic Bacteria in &lt;i&gt;Lycium chinense&lt;/i&gt; Fruits at Different Stages.,2025,10.3390/genes16070836,https://pubmed.ncbi.nlm.nih.gov/40725492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,39149602,"Case report: Rare heterozygous variant in the NR5A1 gene causing 46,XY complete gonadal dysgenesis with a non-communicating rudimentary uterus.",2024,10.3389/fmed.2024.1441990,https://pubmed.ncbi.nlm.nih.gov/39149602/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,40110435,Identification of diagnostic biomarkers of and immune cell infiltration analysis in bovine respiratory disease.,2025,10.3389/fvets.2025.1556676,https://pubmed.ncbi.nlm.nih.gov/40110435/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,42783931,Amino Acid Depletion Reveals Strain- and Nitrogen Source-Dependent Physiological Responses in &lt;i&gt;Brettanomyces bruxellensis&lt;/i&gt;.,2026,10.3390/jof12090636,https://pubmed.ncbi.nlm.nih.gov/42783931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,39609541,Distinguish active tuberculosis with an immune-related signature and molecule subtypes: a multi-cohort analysis.,2024,10.1038/s41598-024-80072-3,https://pubmed.ncbi.nlm.nih.gov/39609541/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,37402769,Whole genome sequencing identifies genetic variants associated with neurogenic inflammation in rosacea.,2023,10.1038/s41467-023-39761-2,https://pubmed.ncbi.nlm.nih.gov/37402769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,36439140,Analysis of signature genes and association with immune cells infiltration in pediatric septic shock.,2022,10.3389/fimmu.2022.1056750,https://pubmed.ncbi.nlm.nih.gov/36439140/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,36733384,The role of intestinal immune cells and matrix metalloproteinases in inflammatory bowel disease.,2022,10.3389/fimmu.2022.1067950,https://pubmed.ncbi.nlm.nih.gov/36733384/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,40005164,Differentiation of Isomeric TAT1-CARNOSINE Peptides by Energy-Resolved Mass Spectrometry and Principal Component Analysis.,2025,10.3390/molecules30040853,https://pubmed.ncbi.nlm.nih.gov/40005164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,36222836,Non-catalytic allostery in α-TAT1 by a phospho-switch drives dynamic microtubule acetylation.,2022,10.1083/jcb.202202100,https://pubmed.ncbi.nlm.nih.gov/36222836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,39518145,The Role of Bladder-Washing Cytology as an Adjunctive Method to Cystoscopy During Follow-Up for Low-Grade TaT1 Non-Muscle-Invasive Bladder Cancer.,2024,10.3390/cancers16213708,https://pubmed.ncbi.nlm.nih.gov/39518145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,40016750,Identification of E3 ubiquitin ligase-based molecular subtypes and prognostic signature regarding prognosis and immune landscape in bladder cancer.,2025,10.1186/s12935-025-03703-3,https://pubmed.ncbi.nlm.nih.gov/40016750/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,36386800,Identification of genes related to sexual differentiation and sterility in embryonic gonads of Mule ducks by transcriptome analysis.,2022,10.3389/fgene.2022.1037810,https://pubmed.ncbi.nlm.nih.gov/36386800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,37958559,Expression Patterns and Functional Analysis of Three SmTAT Genes Encoding Tyrosine Aminotransferases in Salvia miltiorrhiza.,2023,10.3390/ijms242115575,https://pubmed.ncbi.nlm.nih.gov/37958559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,42457459,EAU Guidelines on Nonmuscle-invasive Bladder Cancer (TaT1 and CIS) - A Summary of the 2026 Guidelines Update.,2026,10.1016/j.eururo.2026.04.009,https://pubmed.ncbi.nlm.nih.gov/42457459/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,38005889,"Features of Tat Protein in HIV-1 Sub-Subtype A6 Variants Circulating in the Moscow Region, Russia.",2023,10.3390/v15112212,https://pubmed.ncbi.nlm.nih.gov/38005889/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,39668163,MYO1F regulates T-cell activation and glycolytic metabolism by promoting the acetylation of GAPDH.,2025,10.1038/s41423-024-01247-6,https://pubmed.ncbi.nlm.nih.gov/39668163/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,37957034,Enhancement of adeno-associated virus serotype 6 transduction into T cells with cell-penetrating peptides.,2024,10.1002/jgm.3627,https://pubmed.ncbi.nlm.nih.gov/37957034/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,39434850,Optimization of a lentivirus-mediated gene therapy targeting HIV-1 RNA to eliminate HIV-1-infected cells.,2024,10.1016/j.omtn.2024.102341,https://pubmed.ncbi.nlm.nih.gov/39434850/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,39410541,Integrating Genetic Alterations and Histopathological Features for Enhanced Risk Stratification in Non-Muscle-Invasive Bladder Cancer.,2024,10.3390/diagnostics14192137,https://pubmed.ncbi.nlm.nih.gov/39410541/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,35936781,Clinical Eosinophil-Associated Genes can Serve as a Reliable Predictor of Bladder Urothelial Cancer.,2022,10.3389/fmolb.2022.963455,https://pubmed.ncbi.nlm.nih.gov/35936781/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,37161985,Inhibition of miR-221-3p promotes axonal regeneration and repair of primary sensory neurons via regulating p27 expression.,2023,10.1097/wnr.0000000000001912,https://pubmed.ncbi.nlm.nih.gov/37161985/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,36118901,Bioinformatics searching of diagnostic markers and immune infiltration in polycystic ovary syndrome.,2022,10.3389/fgene.2022.937309,https://pubmed.ncbi.nlm.nih.gov/36118901/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,36768927,Evaluation of the Small Heat Shock Protein Family Members HSPB2 and HSPB3 in Bladder Cancer Prognosis and Progression.,2023,10.3390/ijms24032609,https://pubmed.ncbi.nlm.nih.gov/36768927/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,34493740,RNA-seq profiling reveals PBMC RNA as a potential biomarker for hepatocellular carcinoma.,2021,10.1038/s41598-021-96952-x,https://pubmed.ncbi.nlm.nih.gov/34493740/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,38006387,A robust mRNA signature obtained via recursive ensemble feature selection predicts the responsiveness of omalizumab in moderate-to-severe asthma.,2023,10.1002/clt2.12306,https://pubmed.ncbi.nlm.nih.gov/38006387/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,35739890,Heat Stress Alters the Effect of Eimeria maxima Infection on Ileal Amino Acids Digestibility and Transporters Expression in Meat-Type Chickens.,2022,10.3390/ani12121554,https://pubmed.ncbi.nlm.nih.gov/35739890/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,11834742,"Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9.",2002,10.1074/jbc.m111802200,https://pubmed.ncbi.nlm.nih.gov/11834742/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC26A8,ENSG00000112053,Neither,11278976,"Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling.",2001,10.1074/jbc.m011740200,https://pubmed.ncbi.nlm.nih.gov/11278976/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35G3,ENSG00000164729,Neither,41222000,SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice.,2025,10.7554/elife.107494,https://pubmed.ncbi.nlm.nih.gov/41222000/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35G3,ENSG00000164729,Neither,39098524,Several orphan solute carriers functionally identified as organic cation transporters: Substrates specificity compared with known cation transporters.,2024,10.1016/j.jbc.2024.107629,https://pubmed.ncbi.nlm.nih.gov/39098524/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35G3,ENSG00000164729,Neither,39998322,Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses.,2025,10.1002/alz.14592,https://pubmed.ncbi.nlm.nih.gov/39998322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35G3,ENSG00000164729,Neither,39319462,[Pathogenesis and potential diagnostic biomarkers of atrial fibrillation in Chinese population: a study based on bioinfor-matics].,2024,10.3724/zdxbyxb-2024-0027,https://pubmed.ncbi.nlm.nih.gov/39319462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35G3,ENSG00000164729,Neither,20723894,Low-intensity exercise enhances expression of markers of alternative activation in circulating leukocytes: roles of PPARγ and Th2 cytokines.,2010,10.1016/j.atherosclerosis.2010.07.002,https://pubmed.ncbi.nlm.nih.gov/20723894/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35G3,ENSG00000164729,Neither,11896452,Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759.,2002,10.1038/sj.ejhg.5200750,https://pubmed.ncbi.nlm.nih.gov/11896452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35G3,ENSG00000164729,Neither,17101974,Emergence of primate genes by retrotransposon-mediated sequence transduction.,2006,10.1073/pnas.0603224103,https://pubmed.ncbi.nlm.nih.gov/17101974/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35G4,ENSG00000236396,Neither,40972734,"Diversity of human choline transporters: substrate specificity, kinetic properties, and inhibitor sensitivity.",2025,10.1016/j.bcp.2025.117343,https://pubmed.ncbi.nlm.nih.gov/40972734/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35G4,ENSG00000236396,Neither,39098524,Several orphan solute carriers functionally identified as organic cation transporters: Substrates specificity compared with known cation transporters.,2024,10.1016/j.jbc.2024.107629,https://pubmed.ncbi.nlm.nih.gov/39098524/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,42625604,Integrative single-cell eQTL and multi-omics analyses reveal AIM1 and ANXA1 as immune-related hub genes and potential therapeutic targets in head and neck cancer.,2026,10.3389/fonc.2026.1912193,https://pubmed.ncbi.nlm.nih.gov/42625604/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,41705770,A Dosage-Dependent Dominant-Negative Mechanism of SLC45A2(W74R) in Autosomal Dominant Oculocutaneous Albinism Revealed by Zebrafish Modeling.,2026,10.1167/tvst.15.2.22,https://pubmed.ncbi.nlm.nih.gov/41705770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,41398365,SLC45A2 drives prostate cancer progression through tumor promotion and immune suppression.,2025,10.1038/s41598-025-32340-z,https://pubmed.ncbi.nlm.nih.gov/41398365/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,42764096,Nasal epithelial transcriptome-wide isoform-level expression and asthma endotypes in youth.,2026,10.1016/j.jaci.2026.09.005,https://pubmed.ncbi.nlm.nih.gov/42764096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,42650157,Ocular Phenotypes and Novel &lt;i&gt;SLC45A2&lt;/i&gt; Variants in Patients with Oculocutaneous Albinism Type 4.,2026,10.3390/genes17080963,https://pubmed.ncbi.nlm.nih.gov/42650157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,42737890,Comparative Transcriptomic Profiling Identifies Region- and Phenotypic-Background-Associated Transcriptional Programs Linked to Coat-Color Variation in Junken Meat Sheep.,2026,10.3390/biology15171457,https://pubmed.ncbi.nlm.nih.gov/42737890/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,41872255,A comparative GWAS of eye colour in light and dark eye genetic backgrounds defined by HERC2 rs12913832 polymorphism in a Canadian cohort of European ancestry.,2026,10.1038/s41598-026-44580-8,https://pubmed.ncbi.nlm.nih.gov/41872255/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,41042237,Reduced gene expression and missense mutations in the transporter protein SLC45A2 in a hypopigmented Egyptian rousette fruit bat (Rousettus aegyptiacus).,2026,10.1093/jhered/esaf070,https://pubmed.ncbi.nlm.nih.gov/41042237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,42450590,Transcriptome Analysis Reveals a Follicular Microenvironment Melanogenesis Axis in Black-to-White Coat-Color Transition of Junken Meat Sheep.,2026,10.3390/biology15131042,https://pubmed.ncbi.nlm.nih.gov/42450590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,41993716,Eye pigmentation-based in-ovo chicken sexing via precision breeding.,2026,10.3389/fbioe.2026.1785893,https://pubmed.ncbi.nlm.nih.gov/41993716/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,42525450,The role of adhesins of &lt;i&gt;Fusobacterium nucleatum&lt;/i&gt; in colorectal cancer - a structural perspective.,2026,10.1080/19490976.2026.2709265,https://pubmed.ncbi.nlm.nih.gov/42525450/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,42314468,Integrative genomic and transcriptomic analyses identify key regulators of skin pigmentation in Larimichthys crocea.,2026,10.1016/j.cbd.2026.101907,https://pubmed.ncbi.nlm.nih.gov/42314468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,42376640,&lt;i&gt;OCA2&lt;/i&gt; common variant NM_000275.3:c.574-19A&gt;G affects splicing and is pathogenic.,2026,10.1016/j.ymgmr.2026.101331,https://pubmed.ncbi.nlm.nih.gov/42376640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,41103423,Single-cell profiling deciphering cholesterol metabolism dysregulation in metastatic uveal melanoma and implicating SLC45A2 in its prognosis.,2025,10.3389/fimmu.2025.1660268,https://pubmed.ncbi.nlm.nih.gov/41103423/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,42565097,The genetic architecture of human skin pigmentation: evolution and adaptation across global populations.,2026,10.3389/fgene.2026.1870791,https://pubmed.ncbi.nlm.nih.gov/42565097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,40174834,Evidence for biomolecular condensates formed by the Escherichia coli MatP protein in spatiotemporal regulation of the bacterial cell division cycle.,2025,10.1016/j.ijbiomac.2025.142691,https://pubmed.ncbi.nlm.nih.gov/40174834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,42908400,Disentangling polymer confinement from specific-folding interactions reveals the drivers of Escherichia coli chromosome organization.,2026,10.1093/nar/gkag979,https://pubmed.ncbi.nlm.nih.gov/42908400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,42394945,A rescue assay for genetic diagnosis of oculocutaneous albinism using melanocytic MNT1 knock-out cells.,2026,10.3389/fgene.2026.1821461,https://pubmed.ncbi.nlm.nih.gov/42394945/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,42335782,Genomic and transcriptomic insights into color pigmentation variation in barred chickens.,2026,10.1016/j.psj.2026.107245,https://pubmed.ncbi.nlm.nih.gov/42335782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,41101985,A recessive coat color dilution in Dexter cattle attributed to a missense mutation in SLC45A2.,2025,10.1111/age.70054,https://pubmed.ncbi.nlm.nih.gov/41101985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,41600276,Atten-LTC-Enhanced MoE Model for Agent Trajectory Prediction in Autonomous Driving.,2026,10.3390/s26020479,https://pubmed.ncbi.nlm.nih.gov/41600276/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,40935087,Integrative network toxicology and transcriptomic analysis reveals molecular mechanisms of zinc pyrithione induced sperm damage in zebrafish.,2025,10.1016/j.taap.2025.117547,https://pubmed.ncbi.nlm.nih.gov/40935087/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,39940926,"Association of Genetic Polymorphisms in SLC45A2, TYR, HERC2, and SLC24A in African Women with Melasma: A Pilot Study.",2025,10.3390/ijms26031158,https://pubmed.ncbi.nlm.nih.gov/39940926/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,38638737,Transcriptome-Based Treatment for Melanoma With Brain Metastasis: A Case Report.,2024,10.7759/cureus.56494,https://pubmed.ncbi.nlm.nih.gov/38638737/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,40286213,Inhibition of Tyrosinase and Melanogenesis by Carboxylic Acids: Mechanistic Insights and Safety Evaluation.,2025,10.3390/molecules30071642,https://pubmed.ncbi.nlm.nih.gov/40286213/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,40151148,Glucose uptake in pigment glia suppresses Tau-induced inflammation and photoreceptor degeneration.,2025,10.1242/dmm.052057,https://pubmed.ncbi.nlm.nih.gov/40151148/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,38030918,The molecular landscape of oculocutaneous albinism in India and its therapeutic implications.,2024,10.1038/s41431-023-01496-5,https://pubmed.ncbi.nlm.nih.gov/38030918/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,39315505,Germline Variants in Patients Affected by Both Uveal and Cutaneous Melanoma.,2025,10.1111/pcmr.13199,https://pubmed.ncbi.nlm.nih.gov/39315505/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,40109368,"Allele and genotype frequencies of variants in P450 cytochromes, transports, and DNA repair enzymes in the Dominican Republic population.",2024,10.3389/fphar.2024.1494482,https://pubmed.ncbi.nlm.nih.gov/40109368/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,34334114,Database mining analysis revealed the role of the putative H+/sugar transporter solute carrier family 45 in skin cutaneous melanoma.,2021,10.1080/19336950.2021.1956226,https://pubmed.ncbi.nlm.nih.gov/34334114/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,38544005,Optimization of Clustering and Trajectory for Minimizing Age of Information in Unmanned Aerial Vehicle-Assisted Mobile Edge Computing Network.,2024,10.3390/s24061742,https://pubmed.ncbi.nlm.nih.gov/38544005/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,39034804,[Clinicopathological analysis of gastric adenocarcinoma with elevated serum alpha-fetoprotein and enteroblastic differentiation].,2024,10.3760/cma.j.cn112152-20230710-00004,https://pubmed.ncbi.nlm.nih.gov/39034804/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,28630054,SLC45A2: A Melanoma Antigen with High Tumor Selectivity and Reduced Potential for Autoimmune Toxicity.,2017,10.1158/2326-6066.cir-17-0051,https://pubmed.ncbi.nlm.nih.gov/28630054/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,34739874,Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites.,2021,10.1016/j.molcel.2021.10.011,https://pubmed.ncbi.nlm.nih.gov/34739874/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,36843251,AIM1-dependent high basal salicylic acid accumulation modulates stomatal aperture in rice.,2023,10.1111/nph.18842,https://pubmed.ncbi.nlm.nih.gov/36843251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,34601680,Removal of elemental mercury from flue gas using the magnetic attapulgite by Mn-Cu oxides modification.,2022,10.1007/s11356-021-16777-z,https://pubmed.ncbi.nlm.nih.gov/34601680/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC45A2,ENSG00000164175,Neither,32966160,SLC45A2 protein stability and regulation of melanosome pH determine melanocyte pigmentation.,2020,10.1091/mbc.e20-03-0200,https://pubmed.ncbi.nlm.nih.gov/32966160/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,41703440,"Slc6a9 is distributed in glial cells and neurons across several nervous system regions, whereas Slc6a5 is more restricted to neurons in the caudal brain.",2026,10.1186/s12868-026-00999-3,https://pubmed.ncbi.nlm.nih.gov/41703440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,41977215,Role of the Glycine Transporter GlyT2 in the Neuronal Differentiation of PC12 Cells.,2026,10.3390/ijms27073026,https://pubmed.ncbi.nlm.nih.gov/41977215/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,42768774,A Role for Glycine Transporter-2 Inhibitors in Regulating Accumbal Dopamine Levels and Voluntary Alcohol Intake in Rats.,2026,10.1111/acer.70418,https://pubmed.ncbi.nlm.nih.gov/42768774/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,41975102,GlyT1 (SLC6A9) inhibition in neurological and psychiatric disorders.,2026,10.1007/s00210-026-05276-y,https://pubmed.ncbi.nlm.nih.gov/41975102/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,42756291,Molecularly diverse glycinergic interneurons in the medial deep dorsal horn are interposed between primary sensory afferents and spinal Shox2 interneurons.,2026,10.3389/fncir.2026.1854977,https://pubmed.ncbi.nlm.nih.gov/42756291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,42624950,Antisense oligonucleotide-mediated disruption of mRNA localisation inhibits angiogenesis.,2026,10.1007/s10456-026-10087-z,https://pubmed.ncbi.nlm.nih.gov/42624950/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,40725001,A New GlyT2 Variant Associated with Hyperekplexia.,2025,10.3390/ijms26146753,https://pubmed.ncbi.nlm.nih.gov/40725001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,41698908,A reversible allosteric inhibitor of GlyT2 for neuropathic pain without on-target side effects.,2026,10.1038/s41467-026-69616-5,https://pubmed.ncbi.nlm.nih.gov/41698908/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,41723107,Cancer-associated fibroblasts promote osimertinib resistance in non-small cell lung cancer cells via METTL1-mediated NET1 m&lt;sup&gt;7&lt;/sup&gt;G modification.,2026,10.1038/s41419-026-08505-7,https://pubmed.ncbi.nlm.nih.gov/41723107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,42163165,Gene expression meta-analysis in the prefrontal cortex: unraveling biological underpinnings of suicidal risk.,2026,10.1186/s12888-026-08170-2,https://pubmed.ncbi.nlm.nih.gov/42163165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,41449633,The Role of the RhoA Activating Protein Net1 in Cancer Initiation and Progression.,2026,10.1080/10985549.2025.2605086,https://pubmed.ncbi.nlm.nih.gov/41449633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,41619725,CB&lt;sub&gt;1&lt;/sub&gt;R and GlyT2 interaction in spinal glycinergic circuits drives neuropathic mechanical pain.,2026,10.1016/j.neuron.2025.11.016,https://pubmed.ncbi.nlm.nih.gov/41619725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,39747410,Multiomics analysis reveals the involvement of NET1 in tumour immune regulation and malignant progression.,2025,10.1038/s41598-024-83714-8,https://pubmed.ncbi.nlm.nih.gov/39747410/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,40473627,Control of epithelial tissue organization by mRNA localization.,2025,10.1038/s41467-025-60532-8,https://pubmed.ncbi.nlm.nih.gov/40473627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,42235777,Targeting 2-hydroxyglutarate mediates the antidepressant effects of Hericium coralloides polysaccharide in hyperlipidemia-associated depression.,2026,10.1016/j.ijbiomac.2026.152837,https://pubmed.ncbi.nlm.nih.gov/42235777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,41064056,Familial Hyperekplexia Caused by a Novel Homozygous &lt;i&gt;SLC6A5&lt;/i&gt; Variant: A Case Report.,2026,10.1159/000547752,https://pubmed.ncbi.nlm.nih.gov/41064056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,40765140,Net1 Controls Src Activation to Regulate Breast Cancer Cell Motility and Invasion.,2025,10.1080/10985549.2025.2536115,https://pubmed.ncbi.nlm.nih.gov/40765140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,41284875,Mechanisms of transport and analgesic compounds recognition by glycine transporter 2.,2025,10.1073/pnas.2506722122,https://pubmed.ncbi.nlm.nih.gov/41284875/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,40691875,Sex-Specific Distribution of Glycine Transporter 2 in the Central Nervous System of Adult GlyT2-iCre-tdTomato Mouse Brain.,2025,10.1111/jnc.70135,https://pubmed.ncbi.nlm.nih.gov/40691875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,42252052,Glycine removal from both glycinergic and glutamatergic synapses into astrocytic processes by glycine transporter 1 in the adult mouse spinal cord.,2026,10.1016/j.neulet.2026.138656,https://pubmed.ncbi.nlm.nih.gov/42252052/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,41986873,Identification of Non-competitive and Reversible Inhibitors of Glycine Transporter 2: A Promising Non-opioid Therapeutic Strategy for Neuropathic Pain.,2026,10.1021/acs.jmedchem.5c03329,https://pubmed.ncbi.nlm.nih.gov/41986873/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,42335716,Discovery of novel N-(alkylpiperidinyl) substituted benzamides targeting the glycine transporter 2 with anti-nociceptive effects in neuropathic pain.,2026,10.1016/j.ejmech.2026.119073,https://pubmed.ncbi.nlm.nih.gov/42335716/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,41224221,"Opiranserin injection (Unafra®) as a first-in-class, non-opioid analgesic for the treatment of acute postoperative pain.",2025,10.17085/apm.25369,https://pubmed.ncbi.nlm.nih.gov/41224221/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,39658258,GlyT2-Positive Interneurons Regulate Timing and Variability of Information Transfer in a Cerebellar-Behavioral Loop.,2025,10.1523/jneurosci.1568-24.2024,https://pubmed.ncbi.nlm.nih.gov/39658258/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,39759156,Roles of NET Peptides With Known Antimicrobial Activity and Toxicity in Immune Response.,2024,10.1155/jimr/5528446,https://pubmed.ncbi.nlm.nih.gov/39759156/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,41094186,Modulation of glycine transporters as a novel therapeutic strategy in neuropsychiatry.,2026,10.1007/s00213-025-06915-7,https://pubmed.ncbi.nlm.nih.gov/41094186/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,39697721,Neuroepithelial cell transforming 1 as a key regulator in non-small cell lung cancer: unveiling causal links and therapeutic potentials.,2024,10.21037/tcr-24-587,https://pubmed.ncbi.nlm.nih.gov/39697721/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,40488109,A Benchmark for Physics-informed Machine Learning of Chlorine Concentration States in Water Distribution Networks.,2025,10.1007/s42979-025-04008-y,https://pubmed.ncbi.nlm.nih.gov/40488109/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,40177401,"Exploring the Relationship Between Immune Cells and Scoliosis by Mendelian Randomization, Colocalization Analysis, and SMR.",2025,10.1155/mi/8833556,https://pubmed.ncbi.nlm.nih.gov/40177401/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,38703592,Neoadjuvant management of locally advanced pancreatic ductal adenocarcinoma - Heading towards a promising change in treatment paradigm.,2024,10.1016/j.ctrv.2024.102750,https://pubmed.ncbi.nlm.nih.gov/38703592/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,36917323,AAV-Net1 facilitates the trans-differentiation of supporting cells into hair cells in the murine cochlea.,2023,10.1007/s00018-023-04743-6,https://pubmed.ncbi.nlm.nih.gov/36917323/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,36801676,The predictive value of plasma exosomal lncRNAs/mRNAs in NSCLC patients receiving immunotherapy.,2023,10.1016/j.advms.2023.01.003,https://pubmed.ncbi.nlm.nih.gov/36801676/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,33061457,MiRNA505/NET1 Axis Acts as a CD8+ T-TIL Regulator in Non-Small Cell Lung Cancer.,2020,10.2147/ott.s265859,https://pubmed.ncbi.nlm.nih.gov/33061457/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A5,ENSG00000165970,Neither,9845349,Molecular cloning and functional expression of the human glycine transporter GlyT2 and chromosomal localisation of the gene in the human genome.,1998,10.1016/s0014-5793(98)01390-8,https://pubmed.ncbi.nlm.nih.gov/9845349/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLFNL1,ENSG00000171790,Neither,39760809,Identification and Validation of Alkaliptosis Resistance-Associated Genes in Prostate Cancer Via Transcriptome Sequencing and Prediction of Biochemical Recurrence.,2026,10.1007/s12033-024-01322-3,https://pubmed.ncbi.nlm.nih.gov/39760809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLFNL1,ENSG00000171790,Neither,32561905,CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity.,2020,10.1093/biolre/ioaa084,https://pubmed.ncbi.nlm.nih.gov/32561905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLFNL1,ENSG00000171790,Neither,36217332,Revealing lncRNA Biomarkers Related to Chronic Obstructive Pulmonary Disease Based on Bioinformatics.,2022,10.2147/copd.s354634,https://pubmed.ncbi.nlm.nih.gov/36217332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLFNL1,ENSG00000171790,Neither,34521445,The role of XBP-1-mediated unfolded protein response in colorectal cancer progression-a regulatory mechanism associated with lncRNA-miRNA-mRNA network.,2021,10.1186/s12935-021-02167-5,https://pubmed.ncbi.nlm.nih.gov/34521445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA5B,ENSG00000171478,Neither,27611690,In Silico and Biochemical Characterization of Lysozyme-Like Proteins in the Rat.,2016,10.1371/journal.pone.0161909,https://pubmed.ncbi.nlm.nih.gov/27611690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA5B,ENSG00000171478,Neither,27832206,"Structural, Functional and Phylogenetic Analysis of Sperm Lysozyme-Like Proteins.",2016,10.1371/journal.pone.0166321,https://pubmed.ncbi.nlm.nih.gov/27832206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXN1,ENSG00000203923,Neither,42899482,Tumour Antigen-Specific Antibody Signatures as Diagnostic Biomarkers for Melanoma.,2026,10.1002/ijc.70726,https://pubmed.ncbi.nlm.nih.gov/42899482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXN1,ENSG00000203923,Neither,42074115,Therapeutic Stress-Induced Remodeling of Transposable Elements and TE-Gene Chimeras in KYSE150 Esophageal Squamous Cell Carcinoma Cells.,2026,10.3390/ijms27083471,https://pubmed.ncbi.nlm.nih.gov/42074115/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXN1,ENSG00000203923,Neither,38035272,X chromosome-wide association study of quantitative biomarkers from the Alzheimer's Disease Neuroimaging Initiative study.,2023,10.3389/fnagi.2023.1277731,https://pubmed.ncbi.nlm.nih.gov/38035272/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXN1,ENSG00000203923,Neither,38688863,X-linked genetic associations in sporadic thoracic aortic dissection.,2024,10.1002/ajmg.a.63644,https://pubmed.ncbi.nlm.nih.gov/38688863/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXN2,ENSG00000268988,Neither,32612888,SPANXN2 functions a cell migration inhibitor in testicular germ cell tumor cells.,2020,10.7717/peerj.9358,https://pubmed.ncbi.nlm.nih.gov/32612888/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXN2,ENSG00000268988,Neither,27698795,Whole-exome sequencing identifies variants in invasive pituitary adenomas.,2016,10.3892/ol.2016.5029,https://pubmed.ncbi.nlm.nih.gov/27698795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXN4,ENSG00000189326,Neither,42303781,Omics signature of new-onset mild cognitive impairment and dementia in a population-based study.,2026,10.1038/s41598-026-58117-6,https://pubmed.ncbi.nlm.nih.gov/42303781/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPANXN4,ENSG00000189326,Neither,37520825,Auto-immunoproteomics analysis of COVID-19 ICU patients revealed increased levels of autoantibodies related to the male reproductive system.,2023,10.3389/fphys.2023.1203723,https://pubmed.ncbi.nlm.nih.gov/37520825/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31A3,ENSG00000275969,Neither,31033124,Novel biomarkers for primary biliary cholangitis to improve diagnosis and understand underlying regulatory mechanisms.,2019,10.1111/liv.14128,https://pubmed.ncbi.nlm.nih.gov/31033124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31A6,ENSG00000185775,Neither,41264133,Non-WNT/non-SHH medulloblastoma in siblings: case report and literature review.,2025,10.1007/s12672-025-04038-1,https://pubmed.ncbi.nlm.nih.gov/41264133/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31C1,ENSG00000230246,Neither,34440428,Pseudogene Transcripts in Head and Neck Cancer: Literature Review and In Silico Analysis.,2021,10.3390/genes12081254,https://pubmed.ncbi.nlm.nih.gov/34440428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31C2,ENSG00000177910,Neither,34440428,Pseudogene Transcripts in Head and Neck Cancer: Literature Review and In Silico Analysis.,2021,10.3390/genes12081254,https://pubmed.ncbi.nlm.nih.gov/34440428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31D1,ENSG00000214929,Neither,32243084,Identification and quantification of coding and long non-coding RNAs in stallion spermatozoa separated by density.,2020,10.1111/andr.12791,https://pubmed.ncbi.nlm.nih.gov/32243084/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31D1,ENSG00000214929,Neither,36896575,The human sperm proteome-Toward a panel for male fertility testing.,2023,10.1111/andr.13431,https://pubmed.ncbi.nlm.nih.gov/36896575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31D1,ENSG00000214929,Neither,30626913,"Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression.",2020,10.1038/s41380-018-0336-6,https://pubmed.ncbi.nlm.nih.gov/30626913/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31H1,ENSG00000221843,Neither,42129752,Identification of a rare missense variant in the gene SPATA31H1 associated with hereditary gingival fibromatosis in a large Chinese family.,2026,10.1186/s12903-026-08507-z,https://pubmed.ncbi.nlm.nih.gov/42129752/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31H1,ENSG00000221843,Neither,41056021,"Decoding the triglyceride-glucose index in metabolic dysfunction-associated steatotic liver disease: integrative insights from Mendelian randomization, cross-tissue transcriptomics, and spatial multi-omics.",2026,10.1097/js9.0000000000003576,https://pubmed.ncbi.nlm.nih.gov/41056021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31J1,ENSG00000204661,Neither,41300873,Integrative Long Non-Coding RNA Analysis and Recurrence Prediction in Cervical Cancer Using a Recurrent Neural Network.,2025,10.3390/diagnostics15222848,https://pubmed.ncbi.nlm.nih.gov/41300873/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYE1,ENSG00000136206,Neither,37277920,"Transcriptome-wide profile of 1α,25 dihydroxyvitamin D3 in HTR-8/SVneo cells.",2023,10.1111/jog.15685,https://pubmed.ncbi.nlm.nih.gov/37277920/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYE1,ENSG00000136206,Neither,22763696,Evolution of the Cdk-activator Speedy/RINGO in vertebrates.,2012,10.1007/s00018-012-1050-1,https://pubmed.ncbi.nlm.nih.gov/22763696/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYE3,ENSG00000214300,Neither,40581088,SPDYE3 promotes cell cycle and LUSC progression by regulating the CDC25C/CDK1 pathway.,2025,10.1016/j.biocel.2025.106825,https://pubmed.ncbi.nlm.nih.gov/40581088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYE3,ENSG00000214300,Neither,22763696,Evolution of the Cdk-activator Speedy/RINGO in vertebrates.,2012,10.1007/s00018-012-1050-1,https://pubmed.ncbi.nlm.nih.gov/22763696/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEM2,ENSG00000184560,Neither,42028965,SPEM2 deficiency disrupts spermiation leading to oligoasthenoteratozoospermia and male infertility†.,2026,10.1093/biolre/ioag087,https://pubmed.ncbi.nlm.nih.gov/42028965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEM2,ENSG00000184560,Neither,38421455,"Spem2, a novel testis-enriched gene, is required for spermiogenesis and fertilization in mice.",2024,10.1007/s00018-024-05147-w,https://pubmed.ncbi.nlm.nih.gov/38421455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEM2,ENSG00000184560,Neither,41668650,Actin-related protein T3 is required for acrosome biogenesis and sperm function in mice.,2026,10.1242/dev.205283,https://pubmed.ncbi.nlm.nih.gov/41668650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMAP2L,ENSG00000249693,Neither,31022261,Selection signatures in four German warmblood horse breeds: Tracing breeding history in the modern sport horse.,2019,10.1371/journal.pone.0215913,https://pubmed.ncbi.nlm.nih.gov/31022261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP3,ENSG00000173728,Neither,41550493,Normal spermatogenesis and fertility in &lt;i&gt;Spmip8&lt;/i&gt; deficiency male mice.,2026,10.1016/j.bbrep.2025.102406,https://pubmed.ncbi.nlm.nih.gov/41550493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP3,ENSG00000173728,Neither,20509907,Derivative chromosome 1 and GLUT1 deficiency syndrome in a sibling pair.,2010,10.1186/1755-8166-3-10,https://pubmed.ncbi.nlm.nih.gov/20509907/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP3,ENSG00000173728,Neither,26604137,Whole-exome sequencing of over 4100 men of African ancestry and prostate cancer risk.,2016,10.1093/hmg/ddv462,https://pubmed.ncbi.nlm.nih.gov/26604137/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP7,ENSG00000164500,Neither,41550493,Normal spermatogenesis and fertility in &lt;i&gt;Spmip8&lt;/i&gt; deficiency male mice.,2026,10.1016/j.bbrep.2025.102406,https://pubmed.ncbi.nlm.nih.gov/41550493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP7,ENSG00000164500,Neither,29700843,Spermatogenesis-associated 48 is essential for spermatogenesis in mice.,2018,10.1111/and.13027,https://pubmed.ncbi.nlm.nih.gov/29700843/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP7,ENSG00000164500,Neither,36896575,The human sperm proteome-Toward a panel for male fertility testing.,2023,10.1111/andr.13431,https://pubmed.ncbi.nlm.nih.gov/36896575/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP7,ENSG00000164500,Neither,29263810,Exome-wide study of ankylosing spondylitis demonstrates additional shared genetic background with inflammatory bowel disease.,2016,10.1038/npjgenmed.2016.8,https://pubmed.ncbi.nlm.nih.gov/29263810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX7,ENSG00000187754,Neither,42219486,SomaScan proteomics reveals novel biomarkers in the progression of liver cirrhosis to hepatocellular carcinoma.,2026,10.1186/s12920-026-02398-3,https://pubmed.ncbi.nlm.nih.gov/42219486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX7,ENSG00000187754,Neither,12216073,The SSX gene family: characterization of 9 complete genes.,2002,10.1002/ijc.10634,https://pubmed.ncbi.nlm.nih.gov/12216073/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX7,ENSG00000187754,Neither,35462014,"Detection and molecular characteristics of canine coronavirus in Chengdu city, Southwest China from 2020 to 2021.",2022,10.1016/j.micpath.2022.105548,https://pubmed.ncbi.nlm.nih.gov/35462014/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STKLD1,ENSG00000198870,Neither,36067927,A novel homozygous variant in the GLI1 underlies postaxial polydactyly in a large consanguineous family with intra familial variable phenotypes.,2022,10.1016/j.ejmg.2022.104599,https://pubmed.ncbi.nlm.nih.gov/36067927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STKLD1,ENSG00000198870,Neither,35087831,GLIS Family Zinc Finger 1 was First Linked With Preaxial Polydactyly I in Humans by Stepwise Genetic Analysis.,2021,10.3389/fcell.2021.781388,https://pubmed.ncbi.nlm.nih.gov/35087831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STKLD1,ENSG00000198870,Neither,34721536,A Novel Homozygous Missense Mutation in the Zinc Finger DNA Binding Domain of GLI1 Causes Recessive Post-Axial Polydactyly.,2021,10.3389/fgene.2021.746949,https://pubmed.ncbi.nlm.nih.gov/34721536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SULT6B1,ENSG00000138068,Neither,38757095,The Role of Aryl Hydrocarbon Receptor in Bone Biology.,2024,10.1177/11786469241246674,https://pubmed.ncbi.nlm.nih.gov/38757095/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SULT6B1,ENSG00000138068,Neither,33171978,"Functional Expression of All Human Sulfotransferases in Fission Yeast, Assay Development, and Structural Models for Isoforms SULT4A1 and SULT6B1.",2020,10.3390/biom10111517,https://pubmed.ncbi.nlm.nih.gov/33171978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SULT6B1,ENSG00000138068,Neither,19505954,"Molecular cloning, expression and characterization of a novel mouse SULT6 cytosolic sulfotransferase.",2009,10.1093/jb/mvp087,https://pubmed.ncbi.nlm.nih.gov/19505954/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SULT6B1,ENSG00000138068,Neither,30028994,Effects of human sulfotransferases on the cytotoxicity of 12-hydroxynevirapine.,2018,10.1016/j.bcp.2018.07.016,https://pubmed.ncbi.nlm.nih.gov/30028994/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SULT6B1,ENSG00000138068,Neither,26660633,Human Sulfotransferases Enhance the Cytotoxicity of Tolvaptan.,2016,10.1093/toxsci/kfv311,https://pubmed.ncbi.nlm.nih.gov/26660633/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SULT6B1,ENSG00000138068,Neither,14676822,Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes.,2004,10.1038/sj.tpj.6500223,https://pubmed.ncbi.nlm.nih.gov/14676822/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SULT6B1,ENSG00000138068,Neither,18288952,"Structure, function and polymorphism of human cytosolic sulfotransferases.",2008,10.2174/138920008783571819,https://pubmed.ncbi.nlm.nih.gov/18288952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SULT6B1,ENSG00000138068,Neither,41093098,Human proteome-wide molecular interaction analysis based on AlphaFold3 to evaluate toxicity between PFOS and its alternative F-53B.,2026,10.1016/j.tox.2025.154308,https://pubmed.ncbi.nlm.nih.gov/41093098/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,42913001,The &lt;i&gt;Nematostella&lt;/i&gt; synaptonemal complex mediates divergent and sex-specific meiotic programs.,2026,10.1126/sciadv.aei0758,https://pubmed.ncbi.nlm.nih.gov/42913001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,42399815,O-GlcNAc transferase governs spermatogenic mitotic-to-meiotic transition and progression by coordinating transcription and alternative splicing programs.,2026,10.1186/s11658-026-00972-2,https://pubmed.ncbi.nlm.nih.gov/42399815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,42792869,Ubc9 Mediates SUMO2/3 Modification to Regulate Meiosis in Male Mice.,2026,10.3390/biomedicines14092129,https://pubmed.ncbi.nlm.nih.gov/42792869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,41467312,SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis.,2026,10.1111/cpr.70158,https://pubmed.ncbi.nlm.nih.gov/41467312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,40911633,Distinct cellular and reproductive consequences of meiotic chromosome synapsis defects in syce2 and sycp1 mutant zebrafish.,2025,10.1371/journal.pgen.1011656,https://pubmed.ncbi.nlm.nih.gov/40911633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,41364265,Cell cycle-related biomarker lineage promotes the malignant progression of recurrent IDH wild-type glioma.,2025,10.1007/s12672-025-04121-7,https://pubmed.ncbi.nlm.nih.gov/41364265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,42059593,"The synaptonemal complex: structure, function, and clinical implications†.",2026,10.1093/biolre/ioag092,https://pubmed.ncbi.nlm.nih.gov/42059593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,41784817,Amino acid metabolism-related model for prognosis and immunity in gastric cancer.,2026,10.1007/s00726-026-03507-3,https://pubmed.ncbi.nlm.nih.gov/41784817/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,40905463,Identification of EMT-related subtype and a 9 genes signature predicts the prognosis in osteosarcoma.,2026,10.1080/03008207.2025.2554842,https://pubmed.ncbi.nlm.nih.gov/40905463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,37781512,SRSF1-mediated alternative splicing is required for spermatogenesis.,2023,10.7150/ijbs.83474,https://pubmed.ncbi.nlm.nih.gov/37781512/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,38287193,Variant in the synaptonemal complex protein SYCE2 associates with pregnancy loss through effect on recombination.,2024,10.1038/s41594-023-01209-y,https://pubmed.ncbi.nlm.nih.gov/38287193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,36071143,Coiled-coil structure of meiosis protein TEX12 and conformational regulation by its C-terminal tip.,2022,10.1038/s42003-022-03886-9,https://pubmed.ncbi.nlm.nih.gov/36071143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,33382503,Synaptonemal complex proteins modulate the level of genome integrity in cancers.,2021,10.1111/cas.14791,https://pubmed.ncbi.nlm.nih.gov/33382503/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,36635604,Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3.,2023,10.1038/s41594-022-00909-1,https://pubmed.ncbi.nlm.nih.gov/36635604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,30456351,Somatic role of SYCE2: an insulator that dissociates HP1α from H3K9me3 and potentiates DNA repair.,2018,10.26508/lsa.201800021,https://pubmed.ncbi.nlm.nih.gov/30456351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,34373646,Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12.,2021,10.1038/s41594-021-00636-z,https://pubmed.ncbi.nlm.nih.gov/34373646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,38238555,Developing a prognosis and chemotherapy evaluating model for colon adenocarcinoma based on mitotic catastrophe-related genes.,2024,10.1038/s41598-024-51918-7,https://pubmed.ncbi.nlm.nih.gov/38238555/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,33362856,"Bioinformatics Analysis Reveals an Association Between Cancer Cell Stemness, Gene Mutations, and the Immune Microenvironment in Stomach Adenocarcinoma.",2020,10.3389/fgene.2020.595477,https://pubmed.ncbi.nlm.nih.gov/33362856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,27501182,Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice.,2016,10.1210/en.2016-1272,https://pubmed.ncbi.nlm.nih.gov/27501182/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE2,ENSG00000161860,Neither,22870393,Structural analysis of the human SYCE2-TEX12 complex provides molecular insights into synaptonemal complex assembly.,2012,10.1098/rsob.120099,https://pubmed.ncbi.nlm.nih.gov/22870393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42673516,LncRNA THOR regulates spermatogenesis by interacting with and stabilizing Sycp3 protein in zebrafish†.,2026,10.1093/biolre/ioag185,https://pubmed.ncbi.nlm.nih.gov/42673516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42581641,Characterization of scp3 and Its Expression Dynamics Identifies the Critical Period for Meiotic Initiation in Female Turbot (Scophthalmus maximus).,2026,10.1002/jez.b.70040,https://pubmed.ncbi.nlm.nih.gov/42581641/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42854377,Meiotic recombination proteins in cancer.,2026,10.1016/j.dnarep.2026.103963,https://pubmed.ncbi.nlm.nih.gov/42854377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42791733,Effects of α-Linolenic Acid on Seminiferous Tubule Morphology and UCHL1-Positive Cells in Cultured Testicular Tissue Fragments from a 3-Month-Old &lt;i&gt;Hu&lt;/i&gt; Ram: A Pilot Study.,2026,10.3390/ani16182873,https://pubmed.ncbi.nlm.nih.gov/42791733/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42655206,"&lt;i&gt;Salmonella&lt;/i&gt; Infection Induces Orchitis and Disrupts the Blood-Testis Barrier, Leading to Spermatogenic Disorders in Mice.",2026,10.3390/microorganisms14081862,https://pubmed.ncbi.nlm.nih.gov/42655206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42794648,Study of Estrogen Receptor-Mediated PGx-eQTLs Identifies Genetic Determinants of Breast Cancer Endocrine Therapy Response.,2026,10.3390/ijms27188217,https://pubmed.ncbi.nlm.nih.gov/42794648/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42913001,The &lt;i&gt;Nematostella&lt;/i&gt; synaptonemal complex mediates divergent and sex-specific meiotic programs.,2026,10.1126/sciadv.aei0758,https://pubmed.ncbi.nlm.nih.gov/42913001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,41800303,"The effects of polysaccharides from &lt;i&gt;Inonotus obliquus&lt;/i&gt;, artemisinin, and dihydroartemisinin on the reproductive system of male mice infected with Neospora caninum.",2026,10.3389/fvets.2026.1740054,https://pubmed.ncbi.nlm.nih.gov/41800303/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42511771,Hexaconazole-Induced Male Reproductive Toxicity Through ROS-Mediated Ferroptosis and Impaired Leydig Cell Steroidogenesis.,2026,10.3390/ijms27146428,https://pubmed.ncbi.nlm.nih.gov/42511771/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,41960164,Low-level lasers can improve spermatogenesis in infertile mice by targeting molecular pathways.,2026,10.34172/bi.31018,https://pubmed.ncbi.nlm.nih.gov/41960164/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,41301402,Protective Effects and Potential Mechanisms of D-Aspartate on Testicular Damage Induced by Polystyrene Microplastics.,2025,10.3390/biom15111484,https://pubmed.ncbi.nlm.nih.gov/41301402/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42901046,Effects of cryopreservation on the viability and function of Larimichthys crocea ovarian tissue.,2026,10.1016/j.cryobiol.2026.105725,https://pubmed.ncbi.nlm.nih.gov/42901046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42297203,An asynchronous production line of meiotic prophase I in the mouse fetal ovary.,2026,10.1016/j.yexcr.2026.115099,https://pubmed.ncbi.nlm.nih.gov/42297203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42008046,Gonadal Transcriptomic Atlas Reveals Conserved and Sex-Biased Regulatory Networks in Black-Spotted Croaker (Protonibea diacanthus).,2026,10.1007/s10126-026-10613-6,https://pubmed.ncbi.nlm.nih.gov/42008046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42059593,"The synaptonemal complex: structure, function, and clinical implications†.",2026,10.1093/biolre/ioag092,https://pubmed.ncbi.nlm.nih.gov/42059593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42601346,Continuous darkness is associated with improved growth performance during a high-temperature period and sex-specific modulation of early gonadal development in juvenile yellowtail (Seriola quinqueradiata).,2026,10.1111/jfb.70617,https://pubmed.ncbi.nlm.nih.gov/42601346/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42622507,"Spastic and non-spastic spinal cord injury induce systemic reproductive impairment via alterations in testicular morphology, microenvironment, spermatogenesis, and modulation of sperm parameters.",2026,10.1080/10790268.2026.2709255,https://pubmed.ncbi.nlm.nih.gov/42622507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42337203,Platelet-rich plasma hydrogel supports long-term germ cell maintenance in rat testicular organotypic culture.,2026,10.1007/s10815-026-03936-9,https://pubmed.ncbi.nlm.nih.gov/42337203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42038779,A Comparative Analysis of Culture Systems with Human Amniotic Mesenchymal Stem Cells.,2025,10.18502/jri.v26i4.21086,https://pubmed.ncbi.nlm.nih.gov/42038779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,40854637,scp3 gene expression during ovarian differentiation in Hypoatherina tsurugae (Pisces; Atheriniformes).,2025,10.1016/j.jgeb.2025.100518,https://pubmed.ncbi.nlm.nih.gov/40854637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42314418,Compound probiotics alleviate aflatoxin B1-induced reproductive toxicity in mice by remodeling gut microbiota and testicular metabolome via NRF2 pathway action.,2026,10.1016/j.ecoenv.2026.120378,https://pubmed.ncbi.nlm.nih.gov/42314418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42721757,"Chronic labetalol exposure induced dose-dependent testicular toxicity via disruptingt HPG-axis, spermatogenesis and steroidogenic pathways: A biochemical, molecular and histopathological evidence.",2026,10.1016/j.tice.2026.103924,https://pubmed.ncbi.nlm.nih.gov/42721757/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,41570873,Paternal BPA and BPS exposure induce testicular dysfunction in pubertal male offspring: roles of OCTN2 carnitine transporter disruption and exacerbated oxidative stress/apoptosis.,2026,10.1016/j.envpol.2026.127718,https://pubmed.ncbi.nlm.nih.gov/41570873/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42223568,Docosahexaenoic acid alleviates Ornidazole toxicity related to spermatogenic dysfunction by modulating PPARγ-dependent ER-mitochondrial uncoupling.,2026,10.1007/s11427-025-3314-1,https://pubmed.ncbi.nlm.nih.gov/42223568/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,41086699,Myclobutanil-induced testis damage and apoptotic germ cell death through ER stress and autophagy in mouse testes.,2025,10.1016/j.ecoenv.2025.119213,https://pubmed.ncbi.nlm.nih.gov/41086699/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,41093233,Multi-omics analysis reveals fluorinated liquid crystal monomers BDPrB/EDPrB exposure disrupts the steroid biosynthesis function via inhibition of CYP17A1.,2025,10.1016/j.envpol.2025.127253,https://pubmed.ncbi.nlm.nih.gov/41093233/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,41318009,Development of canine testicular organoid for assessing the effects of environmental exposure.,2026,10.1016/j.reprotox.2025.109117,https://pubmed.ncbi.nlm.nih.gov/41318009/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,41517957,Proteomic analysis of cisplatin-induced spermatogenesis defects in mice.,2026,10.1080/07853890.2026.2612816,https://pubmed.ncbi.nlm.nih.gov/41517957/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,42069234,Impact of 5-alpha reductase inhibitors on male reproductive health: A review of finasteride and dutasteride.,2026,10.1016/j.reprotox.2026.109257,https://pubmed.ncbi.nlm.nih.gov/42069234/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,41202953,Prenatal and postnatal exposure to environmental level arsenic declines male reproductive function by affecting spermatogenesis and maturation in offspring.,2026,10.1016/j.envres.2025.123276,https://pubmed.ncbi.nlm.nih.gov/41202953/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,39679245,Eugenol Nanoparticles Ameliorate Doxorubicin-Induced Spermatogenic Dysfunction by Inhibiting the PINK1/Parkin and BNIP3/NIX Signaling Pathways.,2024,10.2147/ijn.s494056,https://pubmed.ncbi.nlm.nih.gov/39679245/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,40858886,Combination of knockout serum replacement and plasma rich in growth factors does not support in vitro spermatogenesis in mice.,2025,10.1038/s41598-025-16502-7,https://pubmed.ncbi.nlm.nih.gov/40858886/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,38941808,Environmentally relevant estrogens impaired spermatogenesis and sexual behaviors in male and female zebrafish.,2024,10.1016/j.aquatox.2024.107008,https://pubmed.ncbi.nlm.nih.gov/38941808/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,40518506,Histone hyperacetylation disrupts spermatogonial stem cells homeostasis and impairs spermiogenesis.,2025,10.1186/s13287-025-04385-4,https://pubmed.ncbi.nlm.nih.gov/40518506/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,14643120,Azoospermia in patients heterozygous for a mutation in SYCP3.,2003,10.1016/s0140-6736(03)14845-3,https://pubmed.ncbi.nlm.nih.gov/14643120/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP3,ENSG00000139351,Neither,12213195,A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region.,2002,10.1006/geno.2002.6834,https://pubmed.ncbi.nlm.nih.gov/12213195/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,41330508,"Localization, trafficking, and signaling of trace amine-associated receptor 2 in mouse neuroblastoma cells.",2026,10.1016/j.cellsig.2025.112289,https://pubmed.ncbi.nlm.nih.gov/41330508/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,42463873,TAAR Immunopharmacology.,2026,10.1007/164_2026_819,https://pubmed.ncbi.nlm.nih.gov/42463873/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,40564112,"TAAR8 in the Brain: Implications for Dopaminergic Function, Neurogenesis, and Behavior.",2025,10.3390/biomedicines13061391,https://pubmed.ncbi.nlm.nih.gov/40564112/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,41117250,Trace Amine-associated Receptors (TAARs): Candidate Targets in the Treatment of Bipolar Disorders.,2025,10.62641/aep.v53i5.1916,https://pubmed.ncbi.nlm.nih.gov/41117250/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,39944134,Trace amine-associated receptors (TAARs)2-9 knockout mice exhibit reduced wakefulness and disrupted REM sleep.,2024,10.3389/fpsyt.2024.1467964,https://pubmed.ncbi.nlm.nih.gov/39944134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,41311835,TAAR9 knockout increases hippocampal serotonin and alters grooming behavior in rats.,2025,10.3389/fphar.2025.1684029,https://pubmed.ncbi.nlm.nih.gov/41311835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,38927470,TAARs as Novel Therapeutic Targets for the Treatment of Depression: A Narrative Review of the Interconnection with Monoamines and Adult Neurogenesis.,2024,10.3390/biomedicines12061263,https://pubmed.ncbi.nlm.nih.gov/38927470/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,35431833,Trace Amine-Associated Receptor 2 Is Expressed in the Limbic Brain Areas and Is Involved in Dopamine Regulation and Adult Neurogenesis.,2022,10.3389/fnbeh.2022.847410,https://pubmed.ncbi.nlm.nih.gov/35431833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,38002300,Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets.,2023,10.3390/biom13111618,https://pubmed.ncbi.nlm.nih.gov/38002300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,38672247,Trace Amine-Associated Receptors' Role in Immune System Functions.,2024,10.3390/biomedicines12040893,https://pubmed.ncbi.nlm.nih.gov/38672247/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,35681508,Expression of Trace Amine-Associated Receptors in the Murine and Human Hippocampus Based on Public Transcriptomic Data.,2022,10.3390/cells11111813,https://pubmed.ncbi.nlm.nih.gov/35681508/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,37759760,The Expression of Trace Amine-Associated Receptors (TAARs) in Breast Cancer Is Coincident with the Expression of Neuroactive Ligand-Receptor Systems and Depends on Tumor Intrinsic Subtype.,2023,10.3390/biom13091361,https://pubmed.ncbi.nlm.nih.gov/37759760/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,37894992,Expression Pattern of Trace Amine-Associated Receptors during Differentiation of Human Pluripotent Stem Cells to Dopaminergic Neurons.,2023,10.3390/ijms242015313,https://pubmed.ncbi.nlm.nih.gov/37894992/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,36139098,Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6 Expression in the Mental Disorder-Related Brain Areas in Human and Mouse Brain.,2022,10.3390/biom12091259,https://pubmed.ncbi.nlm.nih.gov/36139098/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,35053262,Deregulation of Trace Amine-Associated Receptors (TAAR) Expression and Signaling Mode in Melanoma.,2022,10.3390/biom12010114,https://pubmed.ncbi.nlm.nih.gov/35053262/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,38999982,G Protein-Coupled Receptor-Ligand Pose and Functional Class Prediction.,2024,10.3390/ijms25136876,https://pubmed.ncbi.nlm.nih.gov/38999982/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,37847527,Structure-Based Discovery of Mouse Trace Amine-Associated Receptor 5 Antagonists.,2023,10.1021/acs.jcim.3c00755,https://pubmed.ncbi.nlm.nih.gov/37847527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,30158871,How Female Mice Attract Males: A Urinary Volatile Amine Activates a Trace Amine-Associated Receptor That Induces Male Sexual Interest.,2018,10.3389/fphar.2018.00924,https://pubmed.ncbi.nlm.nih.gov/30158871/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,33132188,Increased dopamine transmission and adult neurogenesis in trace amine-associated receptor 5 (TAAR5) knockout mice.,2021,10.1016/j.neuropharm.2020.108373,https://pubmed.ncbi.nlm.nih.gov/33132188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,23315425,Biogenic amines activate blood leukocytes via trace amine-associated receptors TAAR1 and TAAR2.,2013,10.1189/jlb.0912433,https://pubmed.ncbi.nlm.nih.gov/23315425/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAAR2,ENSG00000146378,Neither,10684976,Cloning and characterization of additional members of the G protein-coupled receptor family.,2000,10.1016/s0167-4781(99)00241-9,https://pubmed.ncbi.nlm.nih.gov/10684976/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1L,ENSG00000122728,Neither,39623292,Clinicopathological features and prognostic significance of TAF1L in gastric cancer.,2024,10.1186/s12876-024-03534-y,https://pubmed.ncbi.nlm.nih.gov/39623292/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1L,ENSG00000122728,Neither,40722090,Construction and validation of acetylation-related gene signatures for immune landscape analysis and prognostication risk prediction in luminal breast cancer.,2025,10.1186/s12935-025-03920-w,https://pubmed.ncbi.nlm.nih.gov/40722090/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1L,ENSG00000122728,Neither,32174793,TAF1L promotes development of oral squamous cell carcinoma via decreasing autophagy-dependent apoptosis.,2020,10.7150/ijbs.41148,https://pubmed.ncbi.nlm.nih.gov/32174793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1L,ENSG00000122728,Neither,30854104,"Overexpression of TAF1L Promotes Cell Proliferation, Migration and Invasion in Esophageal Squamous Cell Carcinoma.",2019,10.7150/jca.26504,https://pubmed.ncbi.nlm.nih.gov/30854104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1L,ENSG00000122728,Neither,36743888,Screening of Lymphoma Radiotherapy-Resistant Genes with CRISPR Activation Library.,2023,10.2147/pgpm.s386085,https://pubmed.ncbi.nlm.nih.gov/36743888/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1L,ENSG00000122728,Neither,34015961,Next-generation sequencing reveals novel mutations in a collision tumor of glioblastoma and meningioma.,2021,10.2217/cns-2020-0029,https://pubmed.ncbi.nlm.nih.gov/34015961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1L,ENSG00000122728,Neither,36844630,Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas.,2023,10.3892/ol.2023.13707,https://pubmed.ncbi.nlm.nih.gov/36844630/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1L,ENSG00000122728,Neither,29346025,Linkage of Metabolic Defects to Activated PIK3CA Alleles in Endothelial Cells Derived from Lymphatic Malformation.,2018,10.1089/lrb.2017.0033,https://pubmed.ncbi.nlm.nih.gov/29346025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1L,ENSG00000122728,Neither,31781186,Mutation Profiling of Premalignant Colorectal Neoplasia.,2019,10.1155/2019/2542640,https://pubmed.ncbi.nlm.nih.gov/31781186/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1L,ENSG00000122728,Neither,28402630,Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains.,2017,10.1021/acs.jmedchem.7b00306,https://pubmed.ncbi.nlm.nih.gov/28402630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1L,ENSG00000122728,Neither,28938622,Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing.,2017,10.18632/oncotarget.19262,https://pubmed.ncbi.nlm.nih.gov/28938622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1L,ENSG00000122728,Neither,29351916,Pathways Impacted by Genomic Alterations in Pulmonary Carcinoid Tumors.,2018,10.1158/1078-0432.ccr-17-0252,https://pubmed.ncbi.nlm.nih.gov/29351916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1L,ENSG00000122728,Neither,24755198,A meta-analysis of somatic mutations from next generation sequencing of 241 melanomas: a road map for the study of genes with potential clinical relevance.,2014,10.1158/1535-7163.mct-13-0804,https://pubmed.ncbi.nlm.nih.gov/24755198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1L,ENSG00000122728,Neither,24007313,Whole transcriptome sequencing identifies tumor-specific mutations in human oral squamous cell carcinoma.,2013,10.1186/1755-8794-6-28,https://pubmed.ncbi.nlm.nih.gov/24007313/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1L,ENSG00000122728,Neither,12217962,Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis.,2002,10.1093/hmg/11.19.2341,https://pubmed.ncbi.nlm.nih.gov/12217962/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1L,ENSG00000122728,Neither,26873642,"An open-label, single-arm, phase 2 study of the Aurora kinase A inhibitor alisertib in patients with advanced urothelial cancer.",2016,10.1007/s10637-016-0328-9,https://pubmed.ncbi.nlm.nih.gov/26873642/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,40156153,Functional Decline of a Bitter Receptor Gene in New World Vultures.,2025,10.1093/molbev/msaf071,https://pubmed.ncbi.nlm.nih.gov/40156153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,41153757,Genetic Variations in Bitter Taste Receptors and COVID-19 in the Canadian Longitudinal Study on Aging.,2025,10.3390/biomedicines13102473,https://pubmed.ncbi.nlm.nih.gov/41153757/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,42117496,Female-Specific Risk of TAS2R Variants in Chronic Rhinosinusitis: A Hospital-Based Cohort Study From the Taiwan Precision Medicine Initiative.,2026,10.1002/alr.70183,https://pubmed.ncbi.nlm.nih.gov/42117496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,37860623,Bitter taste receptors of the zebra finch (Taeniopygia guttata).,2023,10.3389/fphys.2023.1233711,https://pubmed.ncbi.nlm.nih.gov/37860623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,38762464,A longer time to relapse is associated with a larger increase in differences between paired primary and recurrent IDH wild-type glioblastomas at both the transcriptomic and genomic levels.,2024,10.1186/s40478-024-01790-3,https://pubmed.ncbi.nlm.nih.gov/38762464/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,37625013,Anti-HIV drugs lopinavir/ritonavir activate bitter taste receptors.,2023,10.1093/chemse/bjad035,https://pubmed.ncbi.nlm.nih.gov/37625013/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,34785711,Activation of specific bitter taste receptors by olive oil phenolics and secoiridoids.,2021,10.1038/s41598-021-01752-y,https://pubmed.ncbi.nlm.nih.gov/34785711/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,36089978,Extraoral expression and characterization of bitter taste receptors in Astyanax mexicanus (Mexican tetra fish).,2022,10.1096/fba.2022-00032,https://pubmed.ncbi.nlm.nih.gov/36089978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,39633301,Genomic signatures of sensory adaptation and evolution in pangolins.,2024,10.1186/s12864-024-11063-x,https://pubmed.ncbi.nlm.nih.gov/39633301/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,33160623,Bitter taste receptor activation by hop-derived bitter components induces gastrointestinal hormone production in enteroendocrine cells.,2020,10.1016/j.bbrc.2020.10.099,https://pubmed.ncbi.nlm.nih.gov/33160623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,26600671,Amarogentin Displays Immunomodulatory Effects in Human Mast Cells and Keratinocytes.,2015,10.1155/2015/630128,https://pubmed.ncbi.nlm.nih.gov/26600671/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,33824185,Inhibition of Bitter Taste from Oral Tenofovir Alafenamide.,2021,10.1124/molpharm.120.000071,https://pubmed.ncbi.nlm.nih.gov/33824185/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,33253444,Functionally expressed bitter taste receptor TAS2R14 in human epidermal keratinocytes serves as a chemosensory receptor.,2021,10.1111/exd.14250,https://pubmed.ncbi.nlm.nih.gov/33253444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,35205299,Genomic Diversity Profiling and Breed-Specific Evolutionary Signatures of Selection in Arunachali Yak.,2022,10.3390/genes13020254,https://pubmed.ncbi.nlm.nih.gov/35205299/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,27733116,Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys.,2016,10.1186/s12862-016-0783-0,https://pubmed.ncbi.nlm.nih.gov/27733116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,28829355,The Herbal Bitter Drug Gentiana lutea Modulates Lipid Synthesis in Human Keratinocytes In Vitro and In Vivo.,2017,10.3390/ijms18081814,https://pubmed.ncbi.nlm.nih.gov/28829355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,25573083,Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes.,2015,10.1159/000367631,https://pubmed.ncbi.nlm.nih.gov/25573083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,33684909,An Idic(7)(q11.2) Resulting in Two Copies of 7p and Deletion 7q: A Rare Cytogenetic Event in a Case of Acute Myeloid Leukemia.,2021,,https://pubmed.ncbi.nlm.nih.gov/33684909/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,31522667,Mechanisms of Non-coenzyme Action of Thiamine: Protein Targets and Medical Significance.,2019,10.1134/s0006297919080017,https://pubmed.ncbi.nlm.nih.gov/31522667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,27659339,Genetic diversity of bitter taste receptor gene family in Sichuan domestic and Tibetan chicken populations.,2016,10.1007/s12041-016-0684-4,https://pubmed.ncbi.nlm.nih.gov/27659339/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R1,ENSG00000169777,Neither,37806252,Paxlovid mouth likely is mediated by activation of the TAS2R1 bitter receptor by nirmatrelvir.,2023,10.1016/j.bbrc.2023.10.001,https://pubmed.ncbi.nlm.nih.gov/37806252/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R41,ENSG00000221855,Neither,39284855,Genomic study of taste perception genes in African Americans reveals SNPs linked to Alzheimer's disease.,2024,10.1038/s41598-024-71669-9,https://pubmed.ncbi.nlm.nih.gov/39284855/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R41,ENSG00000221855,Neither,40595706,Unravelling the human taste receptor interactome: machine learning and molecular modelling insights into protein-protein interactions.,2025,10.1038/s41538-025-00478-9,https://pubmed.ncbi.nlm.nih.gov/40595706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R41,ENSG00000221855,Neither,39823405,Pooled PPIseq: Screening the SARS-CoV-2 and human interface with a scalable multiplexed protein-protein interaction assay platform.,2025,10.1371/journal.pone.0299440,https://pubmed.ncbi.nlm.nih.gov/39823405/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R41,ENSG00000221855,Neither,37187908,Bioinformatic analysis identifies GPR91 as a potential key gene in brain injury after deep hypothermic low flow.,2023,10.1016/j.heliyon.2023.e15286,https://pubmed.ncbi.nlm.nih.gov/37187908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R41,ENSG00000221855,Neither,33859569,Exploring the Role of Epicardial Adipose Tissue in Coronary Artery Disease From the Difference of Gene Expression.,2021,10.3389/fphys.2021.605811,https://pubmed.ncbi.nlm.nih.gov/33859569/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAS2R41,ENSG00000221855,Neither,30230081,Lineage-specific duplication and adaptive evolution of bitter taste receptor genes in bats.,2018,10.1111/mec.14873,https://pubmed.ncbi.nlm.nih.gov/30230081/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D3F,ENSG00000275954,Neither,40263929,Identification of Anoikis-Related Genes in Gastric Cancer: Bioinformatics and Experimental Validation.,2025,10.1002/cam4.70907,https://pubmed.ncbi.nlm.nih.gov/40263929/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D3F,ENSG00000275954,Neither,38053370,Regulatory role of ceRNA network in B lymphocytes of patients with immune thrombocytopenia.,2023,10.1080/08916934.2023.2281225,https://pubmed.ncbi.nlm.nih.gov/38053370/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D3F,ENSG00000275954,Neither,16863688,"TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.",2006,10.1016/j.ygeno.2006.05.009,https://pubmed.ncbi.nlm.nih.gov/16863688/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,41904889,A Novel Nonsense Variant in TBX15 Transcription Factor Suggests an Expanded Genetic Spectrum Of Submucous Cleft Palate.,2026,10.1016/j.identj.2026.109520,https://pubmed.ncbi.nlm.nih.gov/41904889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,42510133,Genetic and Molecular Basis of Cleft Lip and Palate: A Comprehensive Review.,2026,10.3390/diagnostics16142269,https://pubmed.ncbi.nlm.nih.gov/42510133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,39231932,Chromosome X-wide association study in case control studies of pathologically confirmed Alzheimer's disease in a European population.,2024,10.1038/s41398-024-03058-9,https://pubmed.ncbi.nlm.nih.gov/39231932/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,41958384,Tumor Whole-Genome Sequencing for Prediction of Venous Thromboembolism in Patients With Metastasized Solid Cancer.,2026,10.1161/circgen.124.005182,https://pubmed.ncbi.nlm.nih.gov/41958384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,39871035,Impact and mechanism of the TBX-22 gene mutation G874A on the epithelial-mesenchymal transition in medial edge epithelial cells.,2025,10.1007/s11626-024-00932-0,https://pubmed.ncbi.nlm.nih.gov/39871035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,36901693,"A Comprehensive Genetic Analysis of Slovenian Families with Multiple Cases of Orofacial Clefts Reveals Novel Variants in the Genes IRF6, GRHL3, and TBX22.",2023,10.3390/ijms24054262,https://pubmed.ncbi.nlm.nih.gov/36901693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,33392186,T-Box Transcription Factor 22 Is an Immune Microenvironment-Related Biomarker Associated With the BRAF V600E Mutation in Papillary Thyroid Carcinoma.,2020,10.3389/fcell.2020.590898,https://pubmed.ncbi.nlm.nih.gov/33392186/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,34857492,Essential role of Msx1 in regulating anterior-posterior patterning of the secondary palate in mice.,2022,10.1016/j.jgg.2021.07.006,https://pubmed.ncbi.nlm.nih.gov/34857492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,38035272,X chromosome-wide association study of quantitative biomarkers from the Alzheimer's Disease Neuroimaging Initiative study.,2023,10.3389/fnagi.2023.1277731,https://pubmed.ncbi.nlm.nih.gov/38035272/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,40565519,Comparative Genomic Analysis Across Multiple Species to Identify Candidate Genes Associated with Important Traits in Chickens.,2025,10.3390/genes16060627,https://pubmed.ncbi.nlm.nih.gov/40565519/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,36901988,Genetic Risk Assessment of Nonsyndromic Cleft Lip with or without Cleft Palate by Linking Genetic Networks and Deep Learning Models.,2023,10.3390/ijms24054557,https://pubmed.ncbi.nlm.nih.gov/36901988/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,31596367,DNA hypermethylation of Fgf16 and Tbx22 associated with cleft palate during palatal fusion.,2019,10.1590/1678-7757-2018-0649,https://pubmed.ncbi.nlm.nih.gov/31596367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,30923412,The Role of the Wnt Signaling Pathway in Upper Jaw Development of Chick Embryo.,2019,10.1267/ahc.18038,https://pubmed.ncbi.nlm.nih.gov/30923412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,36294409,Novel Candidate Genes for Non-Syndromic Tooth Agenesis Identified Using Targeted Next-Generation Sequencing.,2022,10.3390/jcm11206089,https://pubmed.ncbi.nlm.nih.gov/36294409/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,31241704,Position-dependent correlation between TBX22 exon 5 methylation and palatal shelf fusion in the development of cleft palate.,2019,10.1590/0001-3765201920180945,https://pubmed.ncbi.nlm.nih.gov/31241704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,29932061,Novel TBX22 mutations in Chinese nonsyndromic cleft lip/palate families.,2018,10.1007/s12041-018-0938-4,https://pubmed.ncbi.nlm.nih.gov/29932061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,35930384,Pigmentary retinopathy with perivascular sparing in a SOFT syndrome patient with a novel homozygous splicing variant in POC1A gene.,2023,10.1080/13816810.2022.2103837,https://pubmed.ncbi.nlm.nih.gov/35930384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,31150594,Regulatory Mechanisms of Soft Palate Development and Malformations.,2019,10.1177/0022034519851786,https://pubmed.ncbi.nlm.nih.gov/31150594/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,32193494,Genetic landscape of autism spectrum disorder in Vietnamese children.,2020,10.1038/s41598-020-61695-8,https://pubmed.ncbi.nlm.nih.gov/32193494/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,19418442,"Alternative splicing, phylogenetic analysis, and craniofacial expression of zebrafish tbx22.",2009,10.1002/dvdy.21962,https://pubmed.ncbi.nlm.nih.gov/19418442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBX22,ENSG00000122145,Neither,25373698,Loss-of-function mutation in the X-linked TBX22 promoter disrupts an ETS-1 binding site and leads to cleft palate.,2015,10.1007/s00439-014-1503-8,https://pubmed.ncbi.nlm.nih.gov/25373698/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCHHL1,ENSG00000182898,Neither,42544840,Repetin Regulates Epidermal Barrier Homeostasis and Is Associated With Inflammatory Skin Diseases.,2026,10.1111/exd.70336,https://pubmed.ncbi.nlm.nih.gov/42544840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCHHL1,ENSG00000182898,Neither,42507397,Altered expression of S100 fused-type proteins in human skin due to ultraviolet B irradiation.,2026,10.1684/ejd.2026.5080,https://pubmed.ncbi.nlm.nih.gov/42507397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCHHL1,ENSG00000182898,Neither,42511034,Exploring the Cyclic Patterns of Secondary Hair Follicles in Cashmere Goats Based on Skin Transcriptome Data.,2026,10.3390/ani16142156,https://pubmed.ncbi.nlm.nih.gov/42511034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCHHL1,ENSG00000182898,Neither,39674634,Correlation and regression analysis of KRT35 and TCHHL1 functional genes for cashmere fineness in Liaoning cashmere goats.,2024,10.1016/j.jgeb.2024.100434,https://pubmed.ncbi.nlm.nih.gov/39674634/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCHHL1,ENSG00000182898,Neither,33133644,Trichohyalin-like 1 protein plays a crucial role in proliferation and anti-apoptosis of normal human keratinocytes and squamous cell carcinoma cells.,2020,10.1038/s41420-020-00344-5,https://pubmed.ncbi.nlm.nih.gov/33133644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCHHL1,ENSG00000182898,Neither,34984527,Uncommon variants in FLG2 and TCHHL1 are associated with remission of atopic dermatitis in a large longitudinal US cohort.,2022,10.1007/s00403-021-02319-7,https://pubmed.ncbi.nlm.nih.gov/34984527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCHHL1,ENSG00000182898,Neither,36707771,"Whole genome sequencing revealed genetic diversity, population structure, and selective signature of Panou Tibetan sheep.",2023,10.1186/s12864-023-09146-2,https://pubmed.ncbi.nlm.nih.gov/36707771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCHHL1,ENSG00000182898,Neither,30610764,Ultraviolet B irradiation increases the expression of trichohyalin-like 1 protein in human skin xenotransplants.,2019,10.1111/ced.13904,https://pubmed.ncbi.nlm.nih.gov/30610764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCHHL1,ENSG00000182898,Neither,36995036,Altered expression of S100 fused-type proteins in an atopic dermatitis skin model.,2023,10.1111/exd.14797,https://pubmed.ncbi.nlm.nih.gov/36995036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCHHL1,ENSG00000182898,Neither,35035485,Clinical Treatment Study of Secondary Multiple Squamous Cell Carcinoma with Psoriasis Vulgaris.,2022,10.1155/2022/9529681,https://pubmed.ncbi.nlm.nih.gov/35035485/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCHHL1,ENSG00000182898,Neither,35371514,The distinct morphological phenotypes of Southeast Asian aborigines are shaped by novel mechanisms for adaptation to tropical rainforests.,2022,10.1093/nsr/nwab072,https://pubmed.ncbi.nlm.nih.gov/35371514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCHHL1,ENSG00000182898,Neither,23376073,"Trichohyalin-like 1 protein, a member of fused S100 proteins, is expressed in normal and pathologic human skin.",2013,10.1016/j.bbrc.2013.01.084,https://pubmed.ncbi.nlm.nih.gov/23376073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCHHL1,ENSG00000182898,Neither,27386862,Post-Transcriptional Regulation of KLF4 by High-Risk Human Papillomaviruses Is Necessary for the Differentiation-Dependent Viral Life Cycle.,2016,10.1371/journal.ppat.1005747,https://pubmed.ncbi.nlm.nih.gov/27386862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCHHL1,ENSG00000182898,Neither,29220522,Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair.,2018,10.1093/hmg/ddx416,https://pubmed.ncbi.nlm.nih.gov/29220522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCHHL1,ENSG00000182898,Neither,28119736,Recent Positive Selection in Genes of the Mammalian Epidermal Differentiation Complex Locus.,2016,10.3389/fgene.2016.00227,https://pubmed.ncbi.nlm.nih.gov/28119736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,42625859,"Dysregulation of piRNA biogenesis-associated proteins in cancer: mechanisms, evidence, and translational constraints.",2026,10.3389/fmolb.2026.1906635,https://pubmed.ncbi.nlm.nih.gov/42625859/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,42552473,TDRD5 facilitates piRNA biogenesis and male fertility through phase separation.,2026,10.1038/s44319-026-00890-6,https://pubmed.ncbi.nlm.nih.gov/42552473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,41023308,PIWI proteins tether the piRNA biogenesis machinery to mitochondria during mammalian spermatogenesis.,2025,10.1038/s44318-025-00579-x,https://pubmed.ncbi.nlm.nih.gov/41023308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,39405012,"Gene and transcript expression patterns, coupled with isoform switching and long non-coding RNA dynamics in adipose tissue, underlie the longevity of Ames dwarf mice.",2025,10.1007/s11357-024-01383-x,https://pubmed.ncbi.nlm.nih.gov/39405012/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,39331689,Loss-of-function variant in TDRD6 cause male infertility with severe oligo-astheno-teratozoospermia in human and mice.,2024,10.1111/jcmm.18580,https://pubmed.ncbi.nlm.nih.gov/39331689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,41736161,Enhancing prostate cancer diagnosis: a machine learning-based biomarker approach.,2026,10.1186/s40246-026-00939-6,https://pubmed.ncbi.nlm.nih.gov/41736161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,42555113,Dynamic protein expression in golden hamster oocytes and embryos reveals extensive post-translational regulation of PIWIL1 during the oocyte-to-embryo transition†.,2026,10.1093/biolre/ioag167,https://pubmed.ncbi.nlm.nih.gov/42555113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,39122675,"Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertility.",2024,10.1038/s41467-024-50930-9,https://pubmed.ncbi.nlm.nih.gov/39122675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,36921513,H3K4me2 cooperates with Wnt/TCF7L2 to regulate TDRD1 and promote chicken spermatogonia stem cell formation.,2023,10.1016/j.psj.2023.102552,https://pubmed.ncbi.nlm.nih.gov/36921513/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,37041411,The cancer testis antigen TDRD1 regulates prostate cancer proliferation by associating with the snRNP biogenesis machinery.,2023,10.1038/s41388-023-02690-x,https://pubmed.ncbi.nlm.nih.gov/37041411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,41330218,Transcriptomic analysis of post-mating neural reprogramming and its coordinated control of ovarian development in the mud crab Scylla paramamosain.,2026,10.1016/j.cbd.2025.101696,https://pubmed.ncbi.nlm.nih.gov/41330218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,39604866,PIWIL genes in hepatocellular carcinoma: a multi-omics approach uncovering dysregulated expression and ceRNA networks in mice.,2024,10.1186/s12863-024-01283-1,https://pubmed.ncbi.nlm.nih.gov/39604866/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,36317868,TCR CDR3-antigen chemical complementarity associated with poor ovarian cancer outcomes: A vestigial immune response to early cancer antigens?,2023,10.1111/aji.13639,https://pubmed.ncbi.nlm.nih.gov/36317868/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,35790000,DNA hypomethylation activation Wnt/TCF7L2/TDRD1 pathway promotes spermatogonial stem cell formation.,2022,10.1002/jcp.30822,https://pubmed.ncbi.nlm.nih.gov/35790000/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,36200047,The Piwil1 N domain is required for germ cell survival in Atlantic salmon.,2022,10.3389/fcell.2022.977779,https://pubmed.ncbi.nlm.nih.gov/36200047/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,32059713,"Testicular expression of TDRD1, TDRD5, TDRD9 and TDRD12 in azoospermia.",2020,10.1186/s12881-020-0970-0,https://pubmed.ncbi.nlm.nih.gov/32059713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,34312369,Polyubiquitin gene Ubb is required for upregulation of Piwi protein level during mouse testis development.,2021,10.1038/s41420-021-00581-2,https://pubmed.ncbi.nlm.nih.gov/34312369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,36497036,LncRNA/miRNA/mRNA Network Introduces Novel Biomarkers in Prostate Cancer.,2022,10.3390/cells11233776,https://pubmed.ncbi.nlm.nih.gov/36497036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,37045473,Specific recognition of an FGFR2 fusion by tumor infiltrating lymphocytes from a patient with metastatic cholangiocarcinoma.,2023,10.1136/jitc-2022-006303,https://pubmed.ncbi.nlm.nih.gov/37045473/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,35425810,"The Tudor Domain-Containing Protein, Kotsubu (CG9925), Localizes to the Nuage and Functions in piRNA Biogenesis in D. melanogaster.",2022,10.3389/fmolb.2022.818302,https://pubmed.ncbi.nlm.nih.gov/35425810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,35347417,Characteristics of the TDRD1 gene promoter in chickens.,2022,10.1007/s00438-022-01886-2,https://pubmed.ncbi.nlm.nih.gov/35347417/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,36439479,A novel prognostic model for prostate cancer based on androgen biosynthetic and catabolic pathways.,2022,10.3389/fonc.2022.950094,https://pubmed.ncbi.nlm.nih.gov/36439479/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,37609819,Analysis between macrophage-related genes with prognosis and tumor microenvironment in non-small cell lung cancer.,2023,10.16288/j.yczz.23-077,https://pubmed.ncbi.nlm.nih.gov/37609819/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,32365144,Effect of ovarian stimulation on the expression of piRNA pathway proteins.,2020,10.1371/journal.pone.0232629,https://pubmed.ncbi.nlm.nih.gov/32365144/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,34239534,Identification of the Functions and Prognostic Values of RNA Binding Proteins in Bladder Cancer.,2021,10.3389/fgene.2021.574196,https://pubmed.ncbi.nlm.nih.gov/34239534/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,27272765,The Germ Cell Gene TDRD1 as an ERG Target Gene and a Novel Prostate Cancer Biomarker.,2016,10.1002/pros.23213,https://pubmed.ncbi.nlm.nih.gov/27272765/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,23555854,ERG induces epigenetic activation of Tudor domain-containing protein 1 (TDRD1) in ERG rearrangement-positive prostate cancer.,2013,10.1371/journal.pone.0059976,https://pubmed.ncbi.nlm.nih.gov/23555854/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,26857646,Stratification of aggressive prostate cancer from indolent disease-Prospective controlled trial utilizing expression of 11 genes in apparently benign tissue.,2016,10.1016/j.urolonc.2015.12.014,https://pubmed.ncbi.nlm.nih.gov/26857646/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,31472347,Arsenic influences spermatogenesis by disorganizing the elongation of spermatids in adult male mice.,2020,10.1016/j.chemosphere.2019.124650,https://pubmed.ncbi.nlm.nih.gov/31472347/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,31330346,Fluoride-induced unrestored arrest during haploid period of spermatogenesis via the regulation of DDX25 in rats.,2019,10.1016/j.envpol.2019.06.107,https://pubmed.ncbi.nlm.nih.gov/31330346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,21515969,Tudor domain-containing protein 4 as a potential cancer/testis antigen in liver cancer.,2011,10.1620/tjem.224.41,https://pubmed.ncbi.nlm.nih.gov/21515969/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,31588660,Prostate Cancer Risk Stratification in Men With a Clinical Suspicion of Prostate Cancer Using a Unique Biparametric MRI and Expression of 11 Genes in Apparently Benign Tissue: Evaluation Using Machine-Learning Techniques.,2020,10.1002/jmri.26945,https://pubmed.ncbi.nlm.nih.gov/31588660/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,24573400,Novel cancer-testis antigen expression on glioma cell lines derived from high-grade glioma patients.,2014,10.3892/or.2014.3049,https://pubmed.ncbi.nlm.nih.gov/24573400/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,24586802,"STK31/TDRD8, a germ cell-specific factor, is dispensable for reproduction in mice.",2014,10.1371/journal.pone.0089471,https://pubmed.ncbi.nlm.nih.gov/24586802/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD1,ENSG00000095627,Neither,12704671,Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia.,2003,10.1002/ijc.11104,https://pubmed.ncbi.nlm.nih.gov/12704671/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD12,ENSG00000173809,Neither,42631111,Pathogenic Variants in PET Complex Encoding Genes &lt;i&gt;TDRD12&lt;/i&gt; and &lt;i&gt;EXD1&lt;/i&gt; Impair piRNA Biogenesis and Cause Male Infertility.,2026,10.1155/humu/7629729,https://pubmed.ncbi.nlm.nih.gov/42631111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD12,ENSG00000173809,Neither,42529575,Mining Chemotherapy Resistance Related Genes in Breast Cancer to Construct a New Prognosis Prediction Model-Based on GEO Database and Real-World Study.,2026,10.1155/humu/1378458,https://pubmed.ncbi.nlm.nih.gov/42529575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD12,ENSG00000173809,Neither,40750267,Loss of Different Domains of TDRD12 Leads to Distinct Male Infertility-Related Phenotypes.,2026,10.1111/cge.70034,https://pubmed.ncbi.nlm.nih.gov/40750267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD12,ENSG00000173809,Neither,37605245,Zebrafish gonad mutant models reveal neuroendocrine mechanisms of brain sexual dimorphism and male mating behaviors of different brain regions.,2023,10.1186/s13293-023-00534-7,https://pubmed.ncbi.nlm.nih.gov/37605245/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD12,ENSG00000173809,Neither,39405012,"Gene and transcript expression patterns, coupled with isoform switching and long non-coding RNA dynamics in adipose tissue, underlie the longevity of Ames dwarf mice.",2025,10.1007/s11357-024-01383-x,https://pubmed.ncbi.nlm.nih.gov/39405012/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD12,ENSG00000173809,Neither,32059713,"Testicular expression of TDRD1, TDRD5, TDRD9 and TDRD12 in azoospermia.",2020,10.1186/s12881-020-0970-0,https://pubmed.ncbi.nlm.nih.gov/32059713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD12,ENSG00000173809,Neither,37073353,Evolutionary dynamics and conserved function of the Tudor domain-containing (TDRD) proteins in teleost fish.,2022,10.1007/s42995-021-00118-7,https://pubmed.ncbi.nlm.nih.gov/37073353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD12,ENSG00000173809,Neither,28590408,Tdrd12 Is Essential for Germ Cell Development and Maintenance in Zebrafish.,2017,10.3390/ijms18061127,https://pubmed.ncbi.nlm.nih.gov/28590408/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD12,ENSG00000173809,Neither,26954166,Tudor Domain Containing Protein TDRD12 Expresses at the Acrosome of Spermatids in Mouse Testis.,2016,10.5713/ajas.15.0436,https://pubmed.ncbi.nlm.nih.gov/26954166/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD12,ENSG00000173809,Neither,31125834,Evolutionary significance and regulated expression of Tdrd family genes in gynogenetic Japanese flounder (Paralichthys olivaceus).,2019,10.1016/j.cbd.2019.05.003,https://pubmed.ncbi.nlm.nih.gov/31125834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD12,ENSG00000173809,Neither,24067652,Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.,2013,10.1073/pnas.1316316110,https://pubmed.ncbi.nlm.nih.gov/24067652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD12,ENSG00000173809,Neither,32787775,Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines.,2020,10.1186/s12864-020-06966-4,https://pubmed.ncbi.nlm.nih.gov/32787775/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD12,ENSG00000173809,Neither,24586802,"STK31/TDRD8, a germ cell-specific factor, is dispensable for reproduction in mice.",2014,10.1371/journal.pone.0089471,https://pubmed.ncbi.nlm.nih.gov/24586802/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD12,ENSG00000173809,Neither,26669262,PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway.,2016,10.1016/j.molcel.2015.11.009,https://pubmed.ncbi.nlm.nih.gov/26669262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD12,ENSG00000173809,Neither,34069992,Meta-Analysis of Heifer Traits Identified Reproductive Pathways in Bos indicus Cattle.,2021,10.3390/genes12050768,https://pubmed.ncbi.nlm.nih.gov/34069992/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD12,ENSG00000173809,Neither,21551254,"Integrated, genome-wide screening for hypomethylated oncogenes in salivary gland adenoid cystic carcinoma.",2011,10.1158/1078-0432.ccr-10-2992,https://pubmed.ncbi.nlm.nih.gov/21551254/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD12,ENSG00000173809,Neither,21863019,A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors.,2011,10.1038/emboj.2011.308,https://pubmed.ncbi.nlm.nih.gov/21863019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD12,ENSG00000173809,Neither,25017056,Molecular analysis of porcine TDRD10 gene: a novel member of the TDRD family.,2014,10.1016/j.gene.2014.07.026,https://pubmed.ncbi.nlm.nih.gov/25017056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD15,ENSG00000218819,Neither,41126281,Tdrd15 is dispensable for male fertility and spermatogenesis in the golden hamster.,2025,10.1186/s40001-025-03285-w,https://pubmed.ncbi.nlm.nih.gov/41126281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD15,ENSG00000218819,Neither,42092854,Cross-population validation of European GWAS loci for metabolic syndrome in Chinese schizophrenia.,2026,10.1186/s12888-026-08144-4,https://pubmed.ncbi.nlm.nih.gov/42092854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD15,ENSG00000218819,Neither,37906396,Transcriptomics profiling reveal the heterogeneity of white and brown adipocyte.,2023,10.1007/s10863-023-09990-7,https://pubmed.ncbi.nlm.nih.gov/37906396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD15,ENSG00000218819,Neither,37073353,Evolutionary dynamics and conserved function of the Tudor domain-containing (TDRD) proteins in teleost fish.,2022,10.1007/s42995-021-00118-7,https://pubmed.ncbi.nlm.nih.gov/37073353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD15,ENSG00000218819,Neither,32931559,Whole genome sequencing identifies allelic ratio distortion in sperm involving genes related to spermatogenesis in a swine model.,2020,10.1093/dnares/dsaa019,https://pubmed.ncbi.nlm.nih.gov/32931559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD15,ENSG00000218819,Neither,33394542,Proteomic analysis from skin swabs reveals a new set of proteins identifying skin impairment in atopic dermatitis.,2021,10.1111/exd.14276,https://pubmed.ncbi.nlm.nih.gov/33394542/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TENT5D,ENSG00000174016,Neither,42247288,The C-terminal region of TENT5 proteins drives ER-associated mRNA polyadenylation via FNDC3 interaction.,2026,10.1016/j.celrep.2026.117501,https://pubmed.ncbi.nlm.nih.gov/42247288/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TENT5D,ENSG00000174016,Neither,42038404,Characterizing miRNA editing patterns in 5 types of cells using single-cell small RNA sequencing data.,2026,10.3389/fbinf.2026.1719535,https://pubmed.ncbi.nlm.nih.gov/42038404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TENT5D,ENSG00000174016,Neither,39794363,Comprehensive analysis of poly(A) tails in mouse testes and ovaries using Nanopore Direct RNA Sequencing.,2025,10.1038/s41597-024-04226-8,https://pubmed.ncbi.nlm.nih.gov/39794363/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TENT5D,ENSG00000174016,Neither,38228861,Novel variations in TENT5D lead to teratozoospermia in infertile patients.,2024,10.1111/andr.13589,https://pubmed.ncbi.nlm.nih.gov/38228861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TENT5D,ENSG00000174016,Neither,38909026,TENT5-mediated polyadenylation of mRNAs encoding secreted proteins is essential for gametogenesis in mice.,2024,10.1038/s41467-024-49479-4,https://pubmed.ncbi.nlm.nih.gov/38909026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TENT5D,ENSG00000174016,Neither,36746179,TENT5D disruption causes oligoasthenoteratozoospermia and male infertility.,2023,10.1111/andr.13407,https://pubmed.ncbi.nlm.nih.gov/36746179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TENT5D,ENSG00000174016,Neither,40407157,TENT5/FAM46: An Enigmatic Family of Secretory Tuners.,2025,10.1111/tra.70011,https://pubmed.ncbi.nlm.nih.gov/40407157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TENT5D,ENSG00000174016,Neither,35256600,Deficiency of X-linked TENT5D causes male infertility by disrupting the mRNA stability during spermatogenesis.,2022,10.1038/s41421-021-00369-9,https://pubmed.ncbi.nlm.nih.gov/35256600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TENT5D,ENSG00000174016,Neither,30057901,"3' RNA Uridylation in Epitranscriptomics, Gene Regulation, and Disease.",2018,10.3389/fmolb.2018.00061,https://pubmed.ncbi.nlm.nih.gov/30057901/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TENT5D,ENSG00000174016,Neither,19540335,Identification of FAM46D as a novel cancer/testis antigen using EST data and serological analysis.,2009,10.1016/j.ygeno.2009.06.001,https://pubmed.ncbi.nlm.nih.gov/19540335/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TENT5D,ENSG00000174016,Neither,27060136,FAM46 proteins are novel eukaryotic non-canonical poly(A) polymerases.,2016,10.1093/nar/gkw222,https://pubmed.ncbi.nlm.nih.gov/27060136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB1,ENSG00000249961,Neither,42443317,Novel variants in LINC and TTM complexes of meiotic chromosome dynamics are associated with meiotic arrest and non-obstructive azoospermia.,2026,10.1038/s10038-026-01492-9,https://pubmed.ncbi.nlm.nih.gov/42443317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB1,ENSG00000249961,Neither,39932629,Genetic insights into non-obstructive azoospermia: Implications for diagnosis and TESE outcomes.,2025,10.1007/s10815-025-03409-5,https://pubmed.ncbi.nlm.nih.gov/39932629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB1,ENSG00000249961,Neither,35081355,The TERB1 MYB domain suppresses telomere erosion in meiotic prophase I.,2022,10.1016/j.celrep.2021.110289,https://pubmed.ncbi.nlm.nih.gov/35081355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB1,ENSG00000249961,Neither,38277113,A report of two homozygous TERB1 protein-truncating variants in two unrelated women with primary infertility.,2024,10.1007/s10815-024-03031-x,https://pubmed.ncbi.nlm.nih.gov/38277113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB1,ENSG00000249961,Neither,36386800,Identification of genes related to sexual differentiation and sterility in embryonic gonads of Mule ducks by transcriptome analysis.,2022,10.3389/fgene.2022.1037810,https://pubmed.ncbi.nlm.nih.gov/36386800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB1,ENSG00000249961,Neither,24885367,Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated protein.,2014,10.1186/1471-2121-15-17,https://pubmed.ncbi.nlm.nih.gov/24885367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB1,ENSG00000249961,Neither,33211200,"Disruption of human meiotic telomere complex genes TERB1, TERB2 and MAJIN in men with non-obstructive azoospermia.",2021,10.1007/s00439-020-02236-1,https://pubmed.ncbi.nlm.nih.gov/33211200/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB1,ENSG00000249961,Neither,32408858,The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back to the common ancestor of metazoans.,2020,10.1186/s12862-020-01612-9,https://pubmed.ncbi.nlm.nih.gov/32408858/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB1,ENSG00000249961,Neither,35172124,Whole-exome sequencing improves the diagnosis and care of men with non-obstructive azoospermia.,2022,10.1016/j.ajhg.2022.01.011,https://pubmed.ncbi.nlm.nih.gov/35172124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB1,ENSG00000249961,Neither,30718482,The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.,2019,10.1038/s41467-019-08437-1,https://pubmed.ncbi.nlm.nih.gov/30718482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB1,ENSG00000249961,Neither,33015044,Tethering of Telomeres to the Nuclear Envelope Is Mediated by SUN1-MAJIN and Possibly Promoted by SPDYA-CDK2 During Meiosis.,2020,10.3389/fcell.2020.00845,https://pubmed.ncbi.nlm.nih.gov/33015044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB1,ENSG00000249961,Neither,32719396,A genomics approach to male infertility.,2020,10.1038/s41436-020-0916-0,https://pubmed.ncbi.nlm.nih.gov/32719396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB1,ENSG00000249961,Neither,29083416,Telomeric TERB1-TRF1 interaction is crucial for male meiosis.,2017,10.1038/nsmb.3496,https://pubmed.ncbi.nlm.nih.gov/29083416/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB1,ENSG00000249961,Neither,32741963,Genetic dissection of spermatogenic arrest through exome analysis: clinical implications for the management of azoospermic men.,2020,10.1038/s41436-020-0907-1,https://pubmed.ncbi.nlm.nih.gov/32741963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB1,ENSG00000249961,Neither,30559341,Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1.,2018,10.1038/s41467-018-07794-7,https://pubmed.ncbi.nlm.nih.gov/30559341/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB1,ENSG00000249961,Neither,29083414,Dissecting the telomere-inner nuclear membrane interface formed in meiosis.,2017,10.1038/nsmb.3493,https://pubmed.ncbi.nlm.nih.gov/29083414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB1,ENSG00000249961,Neither,26548954,MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap.,2015,10.1016/j.cell.2015.10.030,https://pubmed.ncbi.nlm.nih.gov/26548954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TERB1,ENSG00000249961,Neither,24870409,The meiosis-specific modification of mammalian telomeres.,2014,10.4161/cc.29350,https://pubmed.ncbi.nlm.nih.gov/24870409/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX13B,ENSG00000170925,Neither,38741233,TEX13B is essential for metabolic reprogramming during germ cell differentiation.,2024,10.1093/humrep/deae094,https://pubmed.ncbi.nlm.nih.gov/38741233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX13B,ENSG00000170925,Neither,37594251,Scrutinizing the human TEX genes in the context of human male infertility.,2024,10.1111/andr.13511,https://pubmed.ncbi.nlm.nih.gov/37594251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX13B,ENSG00000170925,Neither,33811575,Analysis of mouse male germ cell-specific or -predominant Tex13 family genes encoding proteins with transcriptional repressor activity.,2021,10.1007/s11033-021-06265-5,https://pubmed.ncbi.nlm.nih.gov/33811575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX13B,ENSG00000170925,Neither,14531651,Molecular and cytogenetic characterization of two azoospermic patients with X-autosome translocation.,2003,10.1023/a:1025437329427,https://pubmed.ncbi.nlm.nih.gov/14531651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX13C,ENSG00000282815,Neither,42801374,Comparative evaluation of germ cell-specific promoters identifies robust drivers of transgene expression during mouse spermatogenesis.,2026,10.1007/s11033-026-12822-7,https://pubmed.ncbi.nlm.nih.gov/42801374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX13C,ENSG00000282815,Neither,37594251,Scrutinizing the human TEX genes in the context of human male infertility.,2024,10.1111/andr.13511,https://pubmed.ncbi.nlm.nih.gov/37594251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX13D,ENSG00000282419,Neither,37594251,Scrutinizing the human TEX genes in the context of human male infertility.,2024,10.1111/andr.13511,https://pubmed.ncbi.nlm.nih.gov/37594251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX13D,ENSG00000282419,Neither,33811575,Analysis of mouse male germ cell-specific or -predominant Tex13 family genes encoding proteins with transcriptional repressor activity.,2021,10.1007/s11033-021-06265-5,https://pubmed.ncbi.nlm.nih.gov/33811575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX28,ENSG00000278057,Neither,38881329,An Irak1-Mecp2 tandem duplication mouse model for the study of MECP2 duplication syndrome.,2024,10.1242/dmm.050528,https://pubmed.ncbi.nlm.nih.gov/38881329/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX28,ENSG00000278057,Neither,37594251,Scrutinizing the human TEX genes in the context of human male infertility.,2024,10.1111/andr.13511,https://pubmed.ncbi.nlm.nih.gov/37594251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX28,ENSG00000278057,Neither,19098318,Evaluation of the X-linked high-grade myopia locus (MYP1) with cone dysfunction and color vision deficiencies.,2009,10.1167/iovs.08-2455,https://pubmed.ncbi.nlm.nih.gov/19098318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX28,ENSG00000278057,Neither,26667017,Chimeric transcripts resulting from complex duplications in chromosome Xq28.,2016,10.1007/s00439-015-1614-x,https://pubmed.ncbi.nlm.nih.gov/26667017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX28,ENSG00000278057,Neither,22883432,A partial MECP2 duplication in a mildly affected adult male: a putative role for the 3' untranslated region in the MECP2 duplication phenotype.,2012,10.1186/1471-2350-13-71,https://pubmed.ncbi.nlm.nih.gov/22883432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX28,ENSG00000278057,Neither,9268643,Identification of a gene within the tandem array of red and green color pigment genes.,1997,10.1006/geno.1997.4830,https://pubmed.ncbi.nlm.nih.gov/9268643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX28,ENSG00000278057,Neither,15378397,An insertion/deletion TEX28 polymorphism and its application to analysis of red/green visual pigment gene arrays.,2004,10.1007/s10038-004-0189-5,https://pubmed.ncbi.nlm.nih.gov/15378397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX28,ENSG00000278057,Neither,12594995,Analysis of L-cone/M-cone visual pigment gene arrays in females by long-range PCR.,2003,10.1016/s0042-6989(02)00679-x,https://pubmed.ncbi.nlm.nih.gov/12594995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX35,ENSG00000240021,Neither,41306611,Screening and analysis of plasma differential lncRNA/mRNA in early pregnancy of preeclampsia.,2025,10.4314/mmj.v37i3.7,https://pubmed.ncbi.nlm.nih.gov/41306611/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX35,ENSG00000240021,Neither,17077512,"Identification and characteristics of a novel testis-specific gene, Tsc24, in human and mice.",2006,10.1248/bpb.29.2187,https://pubmed.ncbi.nlm.nih.gov/17077512/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX48,ENSG00000230601,Neither,39208330,"Differential expression and regulation of ADAD1, DMRTC2, PRSS54, SYCE1, SYCP1, TEX101, TEX48, and TMPRSS12 gene profiles in colon cancer tissues and their in vitro response to epigenetic drugs.",2024,10.1371/journal.pone.0307724,https://pubmed.ncbi.nlm.nih.gov/39208330/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX50,ENSG00000232113,Neither,40906813,Testis expressed 50 is essential for maintaining sperm acrosome integrity during epididymal transit.,2025,10.1073/pnas.2507930122,https://pubmed.ncbi.nlm.nih.gov/40906813/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX50,ENSG00000232113,Neither,41828712,Seminal Redox Improvement and Sperm Proteome Remodeling After Deprox-HP Nutraceutical Supplementation in Male Accessory Gland Inflammation: A Pilot Study.,2026,10.3390/ijms27052498,https://pubmed.ncbi.nlm.nih.gov/41828712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,41634254,Deficiency of primate-specific TFDP3 causes male infertility with oligoasthenoteratozoospermia in humans and cynomolgus monkeys.,2026,10.1007/s11427-025-3186-2,https://pubmed.ncbi.nlm.nih.gov/41634254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,42666808,Exploratory proteomic biomarker combinations associated with post-concussion symptoms following a concussion in adolescents.,2026,10.3389/fneur.2026.1872460,https://pubmed.ncbi.nlm.nih.gov/42666808/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,40804146,In Silico Development of a Multi-epitope Vaccine Targeting TFDP3: A Novel Approach for Cancer Immunotherapy.,2025,10.1007/s12013-025-01830-2,https://pubmed.ncbi.nlm.nih.gov/40804146/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,34745961,"TFDP3 as E2F Unique Partner, Has Crucial Roles in Cancer Cells and Testis.",2021,10.3389/fonc.2021.742462,https://pubmed.ncbi.nlm.nih.gov/34745961/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,28797103,"Effects of cancer-testis antigen, TFDP3, on cell cycle regulation and its mechanism in L-02 and HepG2 cell lines in vitro.",2017,10.1371/journal.pone.0182781,https://pubmed.ncbi.nlm.nih.gov/28797103/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,33101773,Cancer testis antigens in myelodysplastic syndromes revisited: a targeted RNA-seq approach.,2020,10.1080/2162402x.2020.1824642,https://pubmed.ncbi.nlm.nih.gov/33101773/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,30235236,TFDP3 regulates the apoptosis and autophagy in breast cancer cell line MDA-MB-231.,2018,10.1371/journal.pone.0203833,https://pubmed.ncbi.nlm.nih.gov/30235236/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,28114432,TFDP3 Regulates Epithelial-Mesenchymal Transition in Breast Cancer.,2017,10.1371/journal.pone.0170573,https://pubmed.ncbi.nlm.nih.gov/28114432/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,27902457,TFDP3 confers chemoresistance in minimal residual disease within childhood T-cell acute lymphoblastic leukemia.,2017,10.18632/oncotarget.13630,https://pubmed.ncbi.nlm.nih.gov/27902457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,33929972,Development and validation of epithelial mesenchymal transition-related prognostic model for hepatocellular carcinoma.,2021,10.18632/aging.202976,https://pubmed.ncbi.nlm.nih.gov/33929972/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,32309437,Identification and Validation of an Individualized EMT-Related Prognostic Risk Score Formula in Gastric Adenocarcinoma Patients.,2020,10.1155/2020/7082408,https://pubmed.ncbi.nlm.nih.gov/32309437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,24406621,TFDP3 was expressed in coordination with E2F1 to inhibit E2F1-mediated apoptosis in prostate cancer.,2014,10.1016/j.gene.2013.12.051,https://pubmed.ncbi.nlm.nih.gov/24406621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,23212661,Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1-dependent apoptotic pathway.,2013,10.1002/hep.26188,https://pubmed.ncbi.nlm.nih.gov/23212661/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,23574628,"Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene.",2013,10.1111/tan.12113,https://pubmed.ncbi.nlm.nih.gov/23574628/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,22482402,[Effects of TFDP3 on regulating the autophagy and apoptosis of LNCaP cells].,2012,,https://pubmed.ncbi.nlm.nih.gov/22482402/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,15083197,Transduction of dendritic cells with recombinant adenovirus encoding HCA661 activates autologous cytotoxic T lymphocytes to target hepatoma cells.,2004,10.1038/sj.bjc.6601706,https://pubmed.ncbi.nlm.nih.gov/15083197/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,26362298,Transcriptional master regulator analysis in breast cancer genetic networks.,2015,10.1016/j.compbiolchem.2015.08.007,https://pubmed.ncbi.nlm.nih.gov/26362298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,17624664,Induction of cytotoxic T cell response against HCA661 positive cancer cells through activation with novel HLA-A *0201 restricted epitopes.,2007,10.1016/j.canlet.2007.06.002,https://pubmed.ncbi.nlm.nih.gov/17624664/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,18782520,[Preparation of the polypeptide antibody against human transcriptional factors TFDP1 and TFDP3].,2008,,https://pubmed.ncbi.nlm.nih.gov/18782520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,17632080,"TFDP3 inhibits E2F1-induced, p53-mediated apoptosis.",2007,10.1016/j.bbrc.2007.06.128,https://pubmed.ncbi.nlm.nih.gov/17632080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,16418725,A functionally distinct member of the DP family of E2F subunits.,2006,10.1038/sj.onc.1209343,https://pubmed.ncbi.nlm.nih.gov/16418725/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFDP3,ENSG00000183434,Neither,12097419,Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.,2002,10.4049/jimmunol.169.2.1102,https://pubmed.ncbi.nlm.nih.gov/12097419/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LY,ENSG00000176679,Neither,38614076,Toward clinical exomes in diagnostics and management of male infertility.,2024,10.1016/j.ajhg.2024.03.013,https://pubmed.ncbi.nlm.nih.gov/38614076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LY,ENSG00000176679,Neither,35710932,Integrated bioinformatics analysis reveals marker genes and immune infiltration for pulmonary arterial hypertension.,2022,10.1038/s41598-022-14307-6,https://pubmed.ncbi.nlm.nih.gov/35710932/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LY,ENSG00000176679,Neither,30760267,Genomic evidence of Y chromosome microchimerism in the endometrium during endometriosis and in cases of infertility.,2019,10.1186/s12958-019-0465-z,https://pubmed.ncbi.nlm.nih.gov/30760267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LY,ENSG00000176679,Neither,33650819,The Contribution of Y Chromosome Genes to Spontaneous Differentiation of Human Embryonic Stem Cells into Embryoid Bodies In Vitro.,2021,10.22074/cellj.2021.7145,https://pubmed.ncbi.nlm.nih.gov/33650819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LY,ENSG00000176679,Neither,18384077,Association of TGIFLX/Y mRNA expression with azoospermia in infertile men.,2008,10.1002/mrd.20906,https://pubmed.ncbi.nlm.nih.gov/18384077/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LY,ENSG00000176679,Neither,18663611,Association of TGIFLX/Y mRNA expression with prostate cancer.,2009,10.1007/s12032-008-9086-7,https://pubmed.ncbi.nlm.nih.gov/18663611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGIF2LY,ENSG00000176679,Neither,12226713,The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon.,2002,10.1007/s00335-002-3010-9,https://pubmed.ncbi.nlm.nih.gov/12226713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGM7,ENSG00000159495,Neither,41425727,Transglutaminase 7 Silencing Inhibits Proliferation and Modulates Inflammatory and Apoptotic Markers in Testicular Germ Cell Tumors.,2025,10.32604/or.2025.070104,https://pubmed.ncbi.nlm.nih.gov/41425727/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGM7,ENSG00000159495,Neither,42525276,Exploratory transcriptomic analysis of low-grade oral epithelial dysplasia and oral squamous cell carcinoma in Chilean patients.,2026,10.1007/s11033-026-12393-7,https://pubmed.ncbi.nlm.nih.gov/42525276/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGM7,ENSG00000159495,Neither,40594127,Comparison of genetic mutations in bladder cancers that arose following radiotherapy for prostate cancer with those in primary bladder cancers.,2025,10.1038/s41598-025-05149-z,https://pubmed.ncbi.nlm.nih.gov/40594127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGM7,ENSG00000159495,Neither,35836867,Identifying the focuses of hereditary gingival fibromatosis with bioinformatics strategies.,2022,,https://pubmed.ncbi.nlm.nih.gov/35836867/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGM7,ENSG00000159495,Neither,38635931,Prognostic Model for High-Grade Neuroendocrine Carcinoma of the Lung Incorporating Genomic Profiling and Poly (ADP-ribose) Polymerase-1 Expression.,2024,10.1200/po.23.00495,https://pubmed.ncbi.nlm.nih.gov/38635931/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGM7,ENSG00000159495,Neither,28423358,Characterization of fusion genes in common and rare epithelial ovarian cancer histologic subtypes.,2017,10.18632/oncotarget.16781,https://pubmed.ncbi.nlm.nih.gov/28423358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGM7,ENSG00000159495,Neither,28248968,Genomic variants reveal differential evolutionary constraints on human transglutaminases and point towards unrecognized significance of transglutaminase 2.,2017,10.1371/journal.pone.0172189,https://pubmed.ncbi.nlm.nih.gov/28248968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGM7,ENSG00000159495,Neither,11390390,"Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z.",2001,10.1074/jbc.m102553200,https://pubmed.ncbi.nlm.nih.gov/11390390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TGM7,ENSG00000159495,Neither,2848748,Organization of the Tgm family of transposable elements in soybean.,1988,10.1093/genetics/120.2.597,https://pubmed.ncbi.nlm.nih.gov/2848748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL2,ENSG00000151005,Neither,41592137,White spot syndrome virus IE1 protein hijacks the host pentose phosphate pathway to fuel viral replication.,2026,10.1371/journal.ppat.1013913,https://pubmed.ncbi.nlm.nih.gov/41592137/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL2,ENSG00000151005,Neither,35627192,Cancer-Testis Gene Biomarkers Discovered in Colon Cancer Patients.,2022,10.3390/genes13050807,https://pubmed.ncbi.nlm.nih.gov/35627192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL2,ENSG00000151005,Neither,36355490,The Expression Patterns of Human Cancer-Testis Genes Are Induced through Epigenetic Drugs in Colon Cancer Cells.,2022,10.3390/ph15111319,https://pubmed.ncbi.nlm.nih.gov/36355490/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL2,ENSG00000151005,Neither,35914715,Comparative proteomics analysis of human FFPE testicular tissues reveals new candidate biomarkers for distinction among azoospermia types and subtypes.,2022,10.1016/j.jprot.2022.104686,https://pubmed.ncbi.nlm.nih.gov/35914715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL2,ENSG00000151005,Neither,38892912,An Exercise Immune Fitness Test to Unravel Disease Mechanisms-A Proof-of-Concept Heart Failure Study.,2024,10.3390/jcm13113200,https://pubmed.ncbi.nlm.nih.gov/38892912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL2,ENSG00000151005,Neither,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL2,ENSG00000151005,Neither,31611995,Prognostic values of transketolase family genes in ovarian cancer.,2019,10.3892/ol.2019.10818,https://pubmed.ncbi.nlm.nih.gov/31611995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL2,ENSG00000151005,Neither,36692643,Metabolic heterogeneity in early-stage lung adenocarcinoma revealed by RNA-seq and scRNA-seq.,2023,10.1007/s12094-023-03082-z,https://pubmed.ncbi.nlm.nih.gov/36692643/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL2,ENSG00000151005,Neither,21233279,Lack of transketolase-like (TKTL) 1 aggravates murine experimental colitis.,2011,10.1152/ajpgi.00323.2010,https://pubmed.ncbi.nlm.nih.gov/21233279/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL2,ENSG00000151005,Neither,16465194,Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted.,2006,10.1038/sj.bjc.6602962,https://pubmed.ncbi.nlm.nih.gov/16465194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL2,ENSG00000151005,Neither,19290028,A review on research progress of transketolase.,2009,10.1007/s12264-009-1113-y,https://pubmed.ncbi.nlm.nih.gov/19290028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL2,ENSG00000151005,Neither,19159596,[Effects of transketolase-like gene TKTL1 on occurrence and metastasis of human nasopharyngeal carcinoma].,2008,,https://pubmed.ncbi.nlm.nih.gov/19159596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL2,ENSG00000151005,Neither,19331662,Overexpression of transketolase-like gene 1 is associated with cell proliferation in uterine cervix cancer.,2009,10.1186/1756-9966-28-43,https://pubmed.ncbi.nlm.nih.gov/19331662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL2,ENSG00000151005,Neither,17321041,Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells.,2007,10.1016/j.canlet.2007.01.010,https://pubmed.ncbi.nlm.nih.gov/17321041/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL2,ENSG00000151005,Neither,18296915,Overexpression of transketolase protein TKTL1 is associated with occurrence and progression in nasopharyngeal carcinoma: a potential therapeutic target in nasopharyngeal carcinoma.,2008,10.4161/cbt.7.4.5479,https://pubmed.ncbi.nlm.nih.gov/18296915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE7,ENSG00000260734,Neither,41927046,Genome-wide association and Mendelian randomization analyses of placental efficiency and piglet birth weight in Danish Large White pigs.,2026,10.5713/ab.250992,https://pubmed.ncbi.nlm.nih.gov/41927046/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM239,ENSG00000198326,Neither,39503754,TMEM106B amyloid filaments in the Biondi bodies of ependymal cells.,2024,10.1007/s00401-024-02807-w,https://pubmed.ncbi.nlm.nih.gov/39503754/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM239,ENSG00000198326,Neither,42638068,[Construction and characterization of a stable Cas9-expressing monoclonal WSL cell line].,2026,10.13345/j.cjb.250933,https://pubmed.ncbi.nlm.nih.gov/42638068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM239,ENSG00000198326,Neither,39024394,A genome-wide CRISPR/Cas9 knockout screen identifies TMEM239 as an important host factor in facilitating African swine fever virus entry into early endosomes.,2024,10.1371/journal.ppat.1012256,https://pubmed.ncbi.nlm.nih.gov/39024394/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM239,ENSG00000198326,Neither,38216777,Identification of Differentially Expressed mRNAs and miRNAs and Related Regulatory Networks in Cumulus Oophorus Complexes Associated with Fertilization.,2024,10.1007/s43032-023-01413-7,https://pubmed.ncbi.nlm.nih.gov/38216777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM247,ENSG00000284701,Neither,34691999,Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders.,2019,10.1093/nsr/nwz108,https://pubmed.ncbi.nlm.nih.gov/34691999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM89,ENSG00000183396,Neither,42881083,4D-DIA proteomics unveils the dual engines of human sperm capacitation.,2026,10.1016/j.repbio.2026.101290,https://pubmed.ncbi.nlm.nih.gov/42881083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS7,ENSG00000176040,Neither,40796295,Loss of function variants in TMPRSS7 linked to a neurodevelopmental disorder disrupt synaptic function.,2025,10.1093/hmg/ddaf137,https://pubmed.ncbi.nlm.nih.gov/40796295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS7,ENSG00000176040,Neither,34070998,Presence of SARS-CoV-2 and Its Entry Factors in Oral Tissues and Cells: A Systematic Review.,2021,10.3390/medicina57060523,https://pubmed.ncbi.nlm.nih.gov/34070998/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS7,ENSG00000176040,Neither,28487959,Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies.,2017,10.3892/ijmm.2017.2972,https://pubmed.ncbi.nlm.nih.gov/28487959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS7,ENSG00000176040,Neither,25029565,Type II transmembrane serine protease gene variants associate with breast cancer.,2014,10.1371/journal.pone.0102519,https://pubmed.ncbi.nlm.nih.gov/25029565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS7,ENSG00000176040,Neither,15853774,Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity.,2005,10.1042/bj20050299,https://pubmed.ncbi.nlm.nih.gov/15853774/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOPAZ1,ENSG00000173769,Neither,37760215,Transcriptome Studies Reveal the N6-Methyladenosine Differences in Testis of Yaks at Juvenile and Sexual Maturity Stages.,2023,10.3390/ani13182815,https://pubmed.ncbi.nlm.nih.gov/37760215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOPAZ1,ENSG00000173769,Neither,34277642,Structural and Functional Characterization of a Testicular Long Non-coding RNA (4930463O16Rik) Identified in the Meiotic Arrest of the Mouse Topaz1 -/- Testes.,2021,10.3389/fcell.2021.700290,https://pubmed.ncbi.nlm.nih.gov/34277642/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOPAZ1,ENSG00000173769,Neither,37982563,Genetics of sleep medication purchases suggests causality from sleep problems to psychiatric traits.,2024,10.1093/sleep/zsad279,https://pubmed.ncbi.nlm.nih.gov/37982563/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOPAZ1,ENSG00000173769,Neither,35751016,Ectopic expression of a combination of 5 genes detects high risk forms of T-cell acute lymphoblastic leukemia.,2022,10.1186/s12864-022-08688-1,https://pubmed.ncbi.nlm.nih.gov/35751016/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOPAZ1,ENSG00000173769,Neither,38833745,Transcriptomic and epigenomic insights into pectoral muscle fiber formation at the late embryonic development in pure chicken lines.,2024,10.1016/j.psj.2024.103882,https://pubmed.ncbi.nlm.nih.gov/38833745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOPAZ1,ENSG00000173769,Neither,35865002,Integrative Genomic and Transcriptomic Analysis of Primary Malignant Gliomas Revealed Different Patterns Between Grades and Somatic Mutations Related to Glioblastoma Prognosis.,2022,10.3389/fmolb.2022.873042,https://pubmed.ncbi.nlm.nih.gov/35865002/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOPAZ1,ENSG00000173769,Neither,26358182,"TOPAZ1, a germ cell specific factor, is essential for male meiotic progression.",2015,10.1016/j.ydbio.2015.09.002,https://pubmed.ncbi.nlm.nih.gov/26358182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOPAZ1,ENSG00000173769,Neither,22069478,"TOPAZ1, a novel germ cell-specific expressed gene conserved during evolution across vertebrates.",2011,10.1371/journal.pone.0026950,https://pubmed.ncbi.nlm.nih.gov/22069478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOPAZ1,ENSG00000173769,Neither,32842956,Genetic control of temperament traits across species: association of autism spectrum disorder risk genes with cattle temperament.,2020,10.1186/s12711-020-00569-z,https://pubmed.ncbi.nlm.nih.gov/32842956/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOPAZ1,ENSG00000173769,Neither,23478628,Novel tumor suppressor candidates on chromosome 3 revealed by NotI-microarrays in cervical cancer.,2013,10.4161/epi.24233,https://pubmed.ncbi.nlm.nih.gov/23478628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TP53TG3,ENSG00000183632,Neither,41080716,Bioinformatics differential expression analysis of the effect of cannabidiol in chronic myeloid leukaemia cell line.,2025,10.1016/j.gmg.2025.100076,https://pubmed.ncbi.nlm.nih.gov/41080716/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TP53TG3,ENSG00000183632,Neither,10534768,"Isolation and characterization of a novel TP53-inducible gene, TP53TG3.",1999,10.1002/(sici)1098-2264(199912)26:4<329::aid-gcc7>3.0.co;2-c,https://pubmed.ncbi.nlm.nih.gov/10534768/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TP53TG3,ENSG00000183632,Neither,20736252,Identification of epistatic effects using a protein-protein interaction database.,2010,10.1093/hmg/ddq356,https://pubmed.ncbi.nlm.nih.gov/20736252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TP53TG3,ENSG00000183632,Neither,22828807,16p11.2-p12.2 duplication syndrome; a genomic condition differentiated from euchromatic variation of 16p11.2.,2013,10.1038/ejhg.2012.144,https://pubmed.ncbi.nlm.nih.gov/22828807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TP53TG3B,ENSG00000261509,Neither,34537824,Multimetric feature selection for analyzing multicategory outcomes of colorectal cancer: random forest and multinomial logistic regression models.,2022,10.1038/s41374-021-00662-x,https://pubmed.ncbi.nlm.nih.gov/34537824/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TP53TG3B,ENSG00000261509,Neither,10534768,"Isolation and characterization of a novel TP53-inducible gene, TP53TG3.",1999,10.1002/(sici)1098-2264(199912)26:4<329::aid-gcc7>3.0.co;2-c,https://pubmed.ncbi.nlm.nih.gov/10534768/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TP53TG3C,ENSG00000205457,Neither,40431640,Anthraquinone-2-Carboxylic Acid Is a Potential Antiviral Candidate Against Influenza Viruses In Vitro and In Vivo.,2025,10.3390/v17050628,https://pubmed.ncbi.nlm.nih.gov/40431640/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TP53TG3C,ENSG00000205457,Neither,10534768,"Isolation and characterization of a novel TP53-inducible gene, TP53TG3.",1999,10.1002/(sici)1098-2264(199912)26:4<329::aid-gcc7>3.0.co;2-c,https://pubmed.ncbi.nlm.nih.gov/10534768/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TP53TG3D,ENSG00000205456,Neither,10534768,"Isolation and characterization of a novel TP53-inducible gene, TP53TG3.",1999,10.1002/(sici)1098-2264(199912)26:4<329::aid-gcc7>3.0.co;2-c,https://pubmed.ncbi.nlm.nih.gov/10534768/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPRX1,ENSG00000178928,Neither,42893511,Sequential TPRX1 and HERVL activation delineates a progression toward the totipotent-like state.,2026,10.1016/j.celrep.2026.118163,https://pubmed.ncbi.nlm.nih.gov/42893511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPRX1,ENSG00000178928,Neither,41554740,OTX2 inhibits human pluripotent stem cell reprogramming toward 8-cell-like and morula-like states.,2026,10.1038/s41467-026-68388-2,https://pubmed.ncbi.nlm.nih.gov/41554740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPRX1,ENSG00000178928,Neither,42557260,Extensive binding of poorly characterized human transcription factors to genomic dark matter.,2026,10.1038/s41467-026-75376-z,https://pubmed.ncbi.nlm.nih.gov/42557260/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPRX1,ENSG00000178928,Neither,41145868,Maternal factor OTX2 regulates human embryonic genome activation and early development.,2025,10.1038/s41588-025-02350-8,https://pubmed.ncbi.nlm.nih.gov/41145868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPRX1,ENSG00000178928,Neither,42448418,Shared molecular dysregulation across neuropsychiatric disorders reveals candidate therapeutic targets.,2026,10.1016/bs.apcsb.2026.04.010,https://pubmed.ncbi.nlm.nih.gov/42448418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPRX1,ENSG00000178928,Neither,40251810,Deciphering Sequence Determinants of Zygotic Genome Activation Genes: Insights From Machine Learning and the ZGAExplorer Platform.,2025,10.1111/cpr.70039,https://pubmed.ncbi.nlm.nih.gov/40251810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPRX1,ENSG00000178928,Neither,39506635,Molecular cloning of PRD-like homeobox genes expressed in bovine oocytes and early IVF embryos.,2024,10.1186/s12864-024-10969-w,https://pubmed.ncbi.nlm.nih.gov/39506635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPRX1,ENSG00000178928,Neither,36074823,Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation.,2022,10.1126/science.abo7923,https://pubmed.ncbi.nlm.nih.gov/36074823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPRX1,ENSG00000178928,Neither,35216671,8C-like cells capture the human zygotic genome activation program in vitro.,2022,10.1016/j.stem.2022.01.014,https://pubmed.ncbi.nlm.nih.gov/35216671/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPRX1,ENSG00000178928,Neither,35934205,Late-Onset Autosomal Dominant Macular Degeneration Caused by Deletion of the CRX Gene.,2023,10.1016/j.ophtha.2022.07.023,https://pubmed.ncbi.nlm.nih.gov/35934205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPRX1,ENSG00000178928,Neither,34097121,"Dynamic Molecular Evolution of Mammalian Homeobox Genes: Duplication, Loss, Divergence and Gene Conversion Sculpt PRD Class Repertoires.",2021,10.1007/s00239-021-10012-6,https://pubmed.ncbi.nlm.nih.gov/34097121/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPRX1,ENSG00000178928,Neither,27412763,Characterization and target genes of nine human PRD-like homeobox domain genes expressed exclusively in early embryos.,2016,10.1038/srep28995,https://pubmed.ncbi.nlm.nih.gov/27412763/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPRX1,ENSG00000178928,Neither,17005330,"Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line.",2007,10.1016/j.gene.2006.07.034,https://pubmed.ncbi.nlm.nih.gov/17005330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPRX1,ENSG00000178928,Neither,21679462,The dynamics of vertebrate homeobox gene evolution: gain and loss of genes in mouse and human lineages.,2011,10.1186/1471-2148-11-169,https://pubmed.ncbi.nlm.nih.gov/21679462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM43,ENSG00000144015,Neither,38622061,Longitudinal profiling of human androgenotes through single-cell analysis unveils paternal gene expression dynamics in early embryo development.,2024,10.1093/humrep/deae072,https://pubmed.ncbi.nlm.nih.gov/38622061/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM43,ENSG00000144015,Neither,30420784,Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity.,2019,10.1038/s41564-018-0285-5,https://pubmed.ncbi.nlm.nih.gov/30420784/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM43,ENSG00000144015,Neither,33162025,Five multicopy gene family genes expressed during the maternal-to-zygotic transition are not essential for mouse development.,2021,10.1016/j.bbrc.2020.11.004,https://pubmed.ncbi.nlm.nih.gov/33162025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM43,ENSG00000144015,Neither,23966205,DUX4 and DUX4 downstream target genes are expressed in fetal FSHD muscles.,2014,10.1093/hmg/ddt409,https://pubmed.ncbi.nlm.nih.gov/23966205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM43,ENSG00000144015,Neither,19703589,"Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.",2009,10.1016/j.gep.2009.08.002,https://pubmed.ncbi.nlm.nih.gov/19703589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM43B,ENSG00000144010,Neither,34175685,Down-regulation of a panel of immune-related lncRNAs in breast cancer.,2021,10.1016/j.prp.2021.153534,https://pubmed.ncbi.nlm.nih.gov/34175685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM43B,ENSG00000144010,Neither,19703589,"Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.",2009,10.1016/j.gep.2009.08.002,https://pubmed.ncbi.nlm.nih.gov/19703589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM48,ENSG00000150244,Neither,41096745,FBXO22 Suppresses Oxidative Stress-Induced ASK1 Activation and Cell Death via Ubiquitination-Dependent Degradation of TRIM48.,2025,10.3390/ijms26199472,https://pubmed.ncbi.nlm.nih.gov/41096745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM48,ENSG00000150244,Neither,42722677,Multi-ancestry genetic architecture of heart failure subtypes.,2026,10.1038/s41467-026-76438-y,https://pubmed.ncbi.nlm.nih.gov/42722677/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM48,ENSG00000150244,Neither,40609779,High-throughput screening of E3 ubiquitin ligases identifies TRIM48 as a novel negative regulator of RIG-I signaling.,2025,10.1016/j.cellsig.2025.111973,https://pubmed.ncbi.nlm.nih.gov/40609779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM48,ENSG00000150244,Neither,31703057,Overexpression of Tripartite Motif-Containing 48 (TRIM48) Inhibits Growth of Human Glioblastoma Cells by Suppressing Extracellular Signal Regulated Kinase 1/2 (ERK1/2) Pathway.,2019,10.12659/msm.916024,https://pubmed.ncbi.nlm.nih.gov/31703057/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM48,ENSG00000150244,Neither,37554218,PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway.,2023,10.1016/j.gendis.2023.02.006,https://pubmed.ncbi.nlm.nih.gov/37554218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM48,ENSG00000150244,Neither,29186683,TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1.,2017,10.1016/j.celrep.2017.11.007,https://pubmed.ncbi.nlm.nih.gov/29186683/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM49,ENSG00000168930,Neither,40956390,Retinitis Pigmentosa-Associated Gene TRIM49 Regulates ULK1-Mediated Autophagy and Photoreceptor Phagocytosis by the Retinal Pigment Epithelium.,2025,10.1002/advs.202512305,https://pubmed.ncbi.nlm.nih.gov/40956390/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM49,ENSG00000168930,Neither,40997315,TRIM49 Deficiency Stabilizes a Galectin-3/EGR1 Transcriptional Complex That Drives Invasiveness of Gastric Adenocarcinoma.,2026,10.1158/0008-5472.can-25-0252,https://pubmed.ncbi.nlm.nih.gov/40997315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM49,ENSG00000168930,Neither,29107100,"Expression, purification, and characterization of the TRIM49 protein.",2018,10.1016/j.pep.2017.10.014,https://pubmed.ncbi.nlm.nih.gov/29107100/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM49,ENSG00000168930,Neither,34850884,Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus.,2022,10.1093/hmg/ddab306,https://pubmed.ncbi.nlm.nih.gov/34850884/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM49,ENSG00000168930,Neither,11018261,"Isolation of a cDNA for a novel human RING finger protein gene, RNF18, by the virtual transcribed sequence (VTS) approach(1).",2000,10.1016/s0167-4781(00)00193-7,https://pubmed.ncbi.nlm.nih.gov/11018261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM49,ENSG00000168930,Neither,17988387,Differential regulation of abundance and deadenylation of maternal transcripts during bovine oocyte maturation in vitro and in vivo.,2007,10.1186/1471-213x-7-125,https://pubmed.ncbi.nlm.nih.gov/17988387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM49,ENSG00000168930,Neither,12531512,"Characterization of mGluR5R, a novel, metabotropic glutamate receptor 5-related gene.",2002,10.1016/s0169-328x(02)00458-8,https://pubmed.ncbi.nlm.nih.gov/12531512/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM49B,ENSG00000182053,Neither,28715588,Caucasian Families Exhibit Significant Linkage of Myopia to Chromosome 11p.,2017,10.1167/iovs.16-21271,https://pubmed.ncbi.nlm.nih.gov/28715588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM49C,ENSG00000204449,Neither,31781598,A Comprehensive Survey of Genomic Alterations in Gastric Cancer Reveals Recurrent Neoantigens as Potential Therapeutic Targets.,2019,10.1155/2019/2183510,https://pubmed.ncbi.nlm.nih.gov/31781598/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM51,ENSG00000124900,Neither,35116291,The role of TRIM51 as a multipurpose biomarker in melanoma.,2021,10.21037/tcr-21-1102,https://pubmed.ncbi.nlm.nih.gov/35116291/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM60,ENSG00000176979,Neither,33184450,The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-κB activation and the innate immune response.,2021,10.1038/s41423-020-00564-w,https://pubmed.ncbi.nlm.nih.gov/33184450/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM60,ENSG00000176979,Neither,21909995,Association of the testis-specific TRIM/RBCC protein RNF33/TRIM60 with the cytoplasmic motor proteins KIF3A and KIF3B.,2012,10.1007/s11010-011-1050-8,https://pubmed.ncbi.nlm.nih.gov/21909995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM60,ENSG00000176979,Neither,21205214,Nuclear factor kappa B and tumor necrosis factor-alpha modulation of transcription of the mouse testis- and pre-implantation development-specific Rnf33/Trim60 gene.,2011,10.1111/j.1742-4658.2010.08002.x,https://pubmed.ncbi.nlm.nih.gov/21205214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM60,ENSG00000176979,Neither,35531338,Long Noncoding RNA Expression Rofiles Elucidate the Potential Roles of lncRNA- XR_003496198 in Duck Hepatitis A Virus Type 1 Infection.,2022,10.3389/fcimb.2022.858537,https://pubmed.ncbi.nlm.nih.gov/35531338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM60,ENSG00000176979,Neither,30926877,Genome-wide association analysis suggests novel loci underlying thyroid antibodies in Hashimoto's thyroiditis.,2019,10.1038/s41598-019-41850-6,https://pubmed.ncbi.nlm.nih.gov/30926877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM60,ENSG00000176979,Neither,12160726,"Use of a common promoter by two juxtaposed and intronless mouse early embryonic genes, Rnf33 and Rnf35: implications in zygotic gene expression.",2002,10.1006/geno.2002.6808,https://pubmed.ncbi.nlm.nih.gov/12160726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM60,ENSG00000176979,Neither,12433986,"Different modes of regulation of transcription and pre-mRNA processing of the structurally juxtaposed homologs, Rnf33 and Rnf35, in eggs and in pre-implantation embryos.",2002,10.1093/nar/gkf623,https://pubmed.ncbi.nlm.nih.gov/12433986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,42237330,TRIM71 suppresses cervical cancer progression by inhibiting Nectin4-mediated Wnt/β-catenin signaling.,2026,10.1186/s13062-026-00843-y,https://pubmed.ncbi.nlm.nih.gov/42237330/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,42346458,RNA-Binding Protein Trim71 Controls Epicardial Cell Migration.,2026,10.3390/jcdd13060237,https://pubmed.ncbi.nlm.nih.gov/42346458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,40892928,The RNA-binding protein TRIM71 is essential for hearing in humans and mice and times auditory sensory organ development.,2025,10.1073/pnas.2505811122,https://pubmed.ncbi.nlm.nih.gov/40892928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,42177918,West Nile Virus inhibits type I interferon response via TRIM71 in human microglial cells.,2026,10.1016/j.antiviral.2026.106448,https://pubmed.ncbi.nlm.nih.gov/42177918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,42828163,Enrichment of the TRIM21-IgG complex in placental villi during HIV-1 infection.,2026,10.3389/fimmu.2026.1922263,https://pubmed.ncbi.nlm.nih.gov/42828163/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,40946392,Neuroendocrine transcriptomics in Eriocheir sinensis: Photoperiod-induced modulation of gonadal development and circadian clock genes in neural tissues.,2025,10.1016/j.cbd.2025.101629,https://pubmed.ncbi.nlm.nih.gov/40946392/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,38833623,TRIM71 mutations cause a neurodevelopmental syndrome featuring ventriculomegaly and hydrocephalus.,2024,10.1093/brain/awae175,https://pubmed.ncbi.nlm.nih.gov/38833623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,39909558,Impaired primitive erythropoiesis and defective vascular development in Trim71-KO embryos.,2025,10.26508/lsa.202402956,https://pubmed.ncbi.nlm.nih.gov/39909558/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,41634840,Multi-omic analysis identifies a multi-step pathology in a case of multiple chorangioma syndrome in monochorionic twins.,2026,10.1186/s13023-026-04228-2,https://pubmed.ncbi.nlm.nih.gov/41634840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,39957073,The RNA-Binding Protein IGF2BP1 Marks Germ Cells but Is Dispensable for Mouse Fertility.,2025,10.1002/mrd.70016,https://pubmed.ncbi.nlm.nih.gov/39957073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,37559904,The cytoplasmic fraction of the histone lysine methyltransferase Setdb1 is essential for embryonic stem cells.,2023,10.1016/j.isci.2023.107386,https://pubmed.ncbi.nlm.nih.gov/37559904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,40398685,TRIM71 bound hsa-miR-30b-5p restores mitochondrial function in a cellular model of Parkinson's disease.,2025,10.1016/j.freeradbiomed.2025.05.394,https://pubmed.ncbi.nlm.nih.gov/40398685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,39579322,Tripartite Motif Containing 71 Suppresses Tumor Growth by Down-Regulating eIF5A2 Expression in Laryngeal Squamous Cell Carcinoma.,2025,10.1007/s12010-024-05084-1,https://pubmed.ncbi.nlm.nih.gov/39579322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,39267787,Oncofetal TRIM71 drives liver cancer carcinogenesis through remodeling CEBPA-mediated serine/glycine metabolism.,2024,10.7150/thno.99633,https://pubmed.ncbi.nlm.nih.gov/39267787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,39522935,Mitochondrial E3 ligase TRIM71 affects mitochondrial complex assembly and sensitizes dopaminergic neuronal cells to apoptosis in Parkinson's Disease (PD).,2024,10.1016/j.biocel.2024.106689,https://pubmed.ncbi.nlm.nih.gov/39522935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,41154818,Elucidating the Molecular Basis of Thermal Stress Response in Juvenile Turbot (&lt;i&gt;Scophthalmus maximus&lt;/i&gt;) via an Integrative Transcriptome-Metabolome Approach.,2025,10.3390/biology14101413,https://pubmed.ncbi.nlm.nih.gov/41154818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,40180090,Human tripartite motif-containing protein 71 NCL-1/HT2A/LIN-41 domain crystal structure and its potential natural inhibitors.,2025,10.1016/j.ijbiomac.2025.142764,https://pubmed.ncbi.nlm.nih.gov/40180090/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,40221318,"Corrigendum to ""Molecular mechanism governing RNA-binding property of mammalian TRIM71 protein"" [Sci. Bull. 69(1) (2024) 72-81].",2025,10.1016/j.scib.2025.04.001,https://pubmed.ncbi.nlm.nih.gov/40221318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,39116200,Protocol for differential analysis of Trim71-associated protein complexes in mouse embryonic stem cells by mass spectrometry using Perseus.,2024,10.1016/j.xpro.2024.103147,https://pubmed.ncbi.nlm.nih.gov/39116200/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,36660859,Glycolytic Pfkp acts as a Lin41 protein kinase to promote endodermal differentiation of embryonic stem cells.,2023,10.15252/embr.202255683,https://pubmed.ncbi.nlm.nih.gov/36660859/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,37979663,RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose-6-phosphate isomerase degradation via TRIM32.,2023,10.1016/j.phrs.2023.106995,https://pubmed.ncbi.nlm.nih.gov/37979663/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,40603987,Genetic etiology of ventriculomegaly in 73 fetuses identified by High-Throughput sequencing.,2025,10.1038/s41598-025-06714-2,https://pubmed.ncbi.nlm.nih.gov/40603987/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,37938186,CSNK2 suppresses autophagy by activating FLN-NHL-containing TRIM proteins.,2024,10.1080/15548627.2023.2281128,https://pubmed.ncbi.nlm.nih.gov/37938186/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,33975917,The stem cell-specific protein TRIM71 inhibits maturation and activity of the prodifferentiation miRNA let-7 via two independent molecular mechanisms.,2021,10.1261/rna.078696.121,https://pubmed.ncbi.nlm.nih.gov/33975917/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,31806618,NANOG and LIN28 dramatically improve human cell reprogramming by modulating LIN41 and canonical WNT activities.,2019,10.1242/bio.047225,https://pubmed.ncbi.nlm.nih.gov/31806618/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,29541383,E3 ubiquitin ligase tripartite motif-containing 71 promotes the proliferation of non-small cell lung cancer through the inhibitor of kappaB-α/nuclear factor kappaB pathway.,2018,10.18632/oncotarget.19075,https://pubmed.ncbi.nlm.nih.gov/29541383/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,31160797,Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.,2019,10.1038/s41590-019-0400-7,https://pubmed.ncbi.nlm.nih.gov/31160797/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,35356930,Investigation of hub genes involved in Turner syndrome using biological informatics methods.,2022,10.1097/md.0000000000029069,https://pubmed.ncbi.nlm.nih.gov/35356930/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,33312357,Comprehensive analysis of the functions and prognostic significance of RNA-binding proteins in bladder urothelial carcinoma.,2020,10.21203/rs.3.rs-44292/v1,https://pubmed.ncbi.nlm.nih.gov/33312357/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,33282932,Toxocara canis Differentially Affects Hepatic MicroRNA Expression in Beagle Dogs at Different Stages of Infection.,2020,10.3389/fvets.2020.587273,https://pubmed.ncbi.nlm.nih.gov/33282932/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,27534418,Late Maternal Folate Supplementation Rescues from Methyl Donor Deficiency-Associated Brain Defects by Restoring Let-7 and miR-34 Pathways.,2017,10.1007/s12035-016-0035-8,https://pubmed.ncbi.nlm.nih.gov/27534418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM71,ENSG00000206557,Neither,15722555,Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation.,2005,10.1074/jbc.m412247200,https://pubmed.ncbi.nlm.nih.gov/15722555/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,40146919,Expression of tripartite motif family-like protein 1 and 2 in early conceptus development and placentation in the pig.,2025,10.1530/raf-24-0107,https://pubmed.ncbi.nlm.nih.gov/40146919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,41233807,TRIML2 promotes malignant progression of head and neck squamous cell carcinoma via canonical Wnt signaling and tumor immune escape.,2025,10.1186/s12967-025-07274-9,https://pubmed.ncbi.nlm.nih.gov/41233807/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,40110305,The function of TRIML2 on the temozolomide resistance in glioblastoma.,2025,10.1097/ms9.0000000000002888,https://pubmed.ncbi.nlm.nih.gov/40110305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,42360372,Zinc finger protein-associated gene signature serves as a potential predictor for prognosis and therapeutic response in lung adenocarcinoma.,2026,10.1007/s00726-026-03528-y,https://pubmed.ncbi.nlm.nih.gov/42360372/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,40276014,LINC02679 regulates TRIML2 to promote gastric cancer proliferation and invasion via targeting miR-5004-3p.,2025,10.1016/j.ncrna.2025.04.001,https://pubmed.ncbi.nlm.nih.gov/40276014/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,42499036,A prognostic risk model based on programmed cell death genes for breast cancer and its potential clinical application.,2026,10.1097/md.0000000000049607,https://pubmed.ncbi.nlm.nih.gov/42499036/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,41000398,Establishment of an anaplastic stratification signature for gastric cancer based on diverse regulated cell-death.,2025,10.3389/fimmu.2025.1606789,https://pubmed.ncbi.nlm.nih.gov/41000398/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,41543394,Surface Marker Identification to Capture Live Circulating Tumor Cells in Metastatic Triple-Negative Breast Cancer.,2026,10.1158/2767-9764.crc-25-0536,https://pubmed.ncbi.nlm.nih.gov/41543394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,31633784,Eutherian-Specific Gene TRIML2 Attenuates Inflammation in the Evolution of Placentation.,2020,10.1093/molbev/msz238,https://pubmed.ncbi.nlm.nih.gov/31633784/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,38850799,Integration RNA bulk and single cell RNA sequencing to explore the change of glycolysis-related immune microenvironment and construct prognostic signature in head and neck squamous cell carcinoma.,2024,10.1016/j.tranon.2024.102021,https://pubmed.ncbi.nlm.nih.gov/38850799/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,35648772,Correction: STAT6 degradation and ubiquitylated TRIML2 are essential for activation of human oncogenic herpesvirus.,2022,10.1371/journal.ppat.1010579,https://pubmed.ncbi.nlm.nih.gov/35648772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,36347471,Genome-wide contribution of common short-tandem repeats to Parkinson's disease genetic risk.,2023,10.1093/brain/awac301,https://pubmed.ncbi.nlm.nih.gov/36347471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,36685979,Developing a pyroptosis-related gene signature to better predict the prognosis and immune status of patients with head and neck squamous cell carcinoma.,2022,10.3389/fgene.2022.988606,https://pubmed.ncbi.nlm.nih.gov/36685979/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,38406143,A Genome-Wide Association Study of Prostate Cancer Susceptibility Using Occupational and Environmental Factors as Confounding Factors.,2024,10.7759/cureus.52926,https://pubmed.ncbi.nlm.nih.gov/38406143/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,33553602,The pan-cancer lncRNA MILIP links c-Myc to p53 repression.,2020,10.1080/23723556.2020.1842714,https://pubmed.ncbi.nlm.nih.gov/33553602/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,33020477,c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis.,2020,10.1038/s41467-020-18735-8,https://pubmed.ncbi.nlm.nih.gov/33020477/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,35865002,Integrative Genomic and Transcriptomic Analysis of Primary Malignant Gliomas Revealed Different Patterns Between Grades and Somatic Mutations Related to Glioblastoma Prognosis.,2022,10.3389/fmolb.2022.873042,https://pubmed.ncbi.nlm.nih.gov/35865002/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,30554657,Increased expression of tripartite motif (TRIM) like 2 promotes tumoral growth in human oral cancer.,2019,10.1016/j.bbrc.2018.12.060,https://pubmed.ncbi.nlm.nih.gov/30554657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,31565554,Characterization of ceRNA network to reveal potential prognostic biomarkers in triple-negative breast cancer.,2019,10.7717/peerj.7522,https://pubmed.ncbi.nlm.nih.gov/31565554/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,34794455,Prenatal diagnosis of a 4.5-Mb deletion at chromosome 4q35.1q35.2: Case report and literature review.,2021,10.1186/s13039-021-00573-y,https://pubmed.ncbi.nlm.nih.gov/34794455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIML2,ENSG00000179046,Neither,37982419,Deciphering the DNA methylome in women with PCOS diagnosed using the new international evidence-based guidelines.,2023,10.1093/humrep/dead191,https://pubmed.ncbi.nlm.nih.gov/37982419/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA13,ENSG00000213265,Neither,42036012,Integrative analysis of lactylation patterns reveals prognostic biomarkers and therapeutic targets in pancreatic cancer.,2026,10.1016/j.canlet.2026.218536,https://pubmed.ncbi.nlm.nih.gov/42036012/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA13,ENSG00000213265,Neither,31181311,Potential association between TSGA13 variants and risk of total colonic aganglionosis in Hirschsprung disease.,2019,10.1016/j.gene.2019.06.007,https://pubmed.ncbi.nlm.nih.gov/31181311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA13,ENSG00000213265,Neither,26111495,Histochemical analysis of testis specific gene 13 in human normal and malignant tissues.,2015,10.1007/s00441-015-2227-3,https://pubmed.ncbi.nlm.nih.gov/26111495/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA13,ENSG00000213265,Neither,14962666,Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST-flanking region at human chromosome 7q32.,2004,10.1016/j.ygeno.2003.08.016,https://pubmed.ncbi.nlm.nih.gov/14962666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,39909973,Identification of YBX2 and TSKS As STK33 Interacting Proteins in Testicular Germ Cells.,2025,10.1007/s43032-025-01798-7,https://pubmed.ncbi.nlm.nih.gov/39909973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,36881620,TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation.,2023,10.1073/pnas.2221762120,https://pubmed.ncbi.nlm.nih.gov/36881620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,38867481,Gene expression landscape of cutaneous squamous cell carcinoma progression.,2024,10.1093/bjd/ljae249,https://pubmed.ncbi.nlm.nih.gov/38867481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,36438481,"Signatures of EMT, immunosuppression, and inflammation in primary and recurrent human cutaneous squamous cell carcinoma at single-cell resolution.",2022,10.7150/thno.77528,https://pubmed.ncbi.nlm.nih.gov/36438481/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,26777341,Recombinant production of enzymatically active male contraceptive drug target hTSSK2 - Localization of the TSKS domain phosphorylated by TSSK2.,2016,10.1016/j.pep.2016.01.009,https://pubmed.ncbi.nlm.nih.gov/26777341/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,29866902,Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes.,2018,10.1242/dev.164855,https://pubmed.ncbi.nlm.nih.gov/29866902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,24088291,PPP1CC2 can form a kinase/phosphatase complex with the testis-specific proteins TSSK1 and TSKS in the mouse testis.,2014,10.1530/rep-13-0224,https://pubmed.ncbi.nlm.nih.gov/24088291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,36048845,Exome sequencing and functional analyses revealed CETN1 variants leads to impaired cell division and male fertility.,2023,10.1093/hmg/ddac216,https://pubmed.ncbi.nlm.nih.gov/36048845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,18533145,Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency.,2008,10.1016/j.ydbio.2008.03.047,https://pubmed.ncbi.nlm.nih.gov/18533145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,18495105,TSKS concentrates in spermatid centrioles during flagellogenesis.,2008,10.1016/j.ydbio.2008.03.043,https://pubmed.ncbi.nlm.nih.gov/18495105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,17566264,"Validation of a testis specific serine/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets.",2007,,https://pubmed.ncbi.nlm.nih.gov/17566264/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,31983282,DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy.,2020,10.1080/15548627.2019.1710430,https://pubmed.ncbi.nlm.nih.gov/31983282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,26828204,Validation of Cis and Trans Modes in Multistep Phosphotransfer Signaling of Bacterial Tripartite Sensor Kinases by Using Phos-Tag SDS-PAGE.,2016,10.1371/journal.pone.0148294,https://pubmed.ncbi.nlm.nih.gov/26828204/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,11444856,Identification and characterization of a novel human testis-specific kinase substrate gene which is downregulated in testicular tumors.,2001,10.1006/bbrc.2001.5165,https://pubmed.ncbi.nlm.nih.gov/11444856/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,15044604,Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm.,2004,10.1093/molehr/gah052,https://pubmed.ncbi.nlm.nih.gov/15044604/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,19894803,Travel-time sensitivity kernels in long-range propagation.,2009,10.1121/1.3224835,https://pubmed.ncbi.nlm.nih.gov/19894803/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,20053632,Functional transformation of the chromatoid body in mouse spermatids requires testis-specific serine/threonine kinases.,2010,10.1242/jcs.059949,https://pubmed.ncbi.nlm.nih.gov/20053632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,20041336,Effects of season on sleep and skin temperature in the elderly.,2010,10.1007/s00484-009-0291-7,https://pubmed.ncbi.nlm.nih.gov/20041336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSKS,ENSG00000126467,Neither,12939533,Effects of hyperoxia on thermoregulatory responses during feet immersion to hot water in humans.,2003,10.2114/jpa.22.181,https://pubmed.ncbi.nlm.nih.gov/12939533/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,42228803,Development of TSSK1 and TSSK2 Targeted Degraders Reveals Sperm Machinery for Protein Degradation and Potential for Nonhormonal Male Contraception.,2026,10.1021/acs.jmedchem.5c03689,https://pubmed.ncbi.nlm.nih.gov/42228803/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,41042594,The late chromatoid body component TSSK2 is involved in translational regulation in elongating spermatids in mice.,2025,10.1530/rep-25-0297,https://pubmed.ncbi.nlm.nih.gov/41042594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,40305308,Identification of TSSK1 and TSSK2 as Novel Targets for Male Contraception.,2025,10.3390/biom15040601,https://pubmed.ncbi.nlm.nih.gov/40305308/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,40884870,Construction and differential analysis of testicular atlas between 10-week-old and 23-week-old ducks using single-cell RNA sequencing.,2025,10.1016/j.psj.2025.105715,https://pubmed.ncbi.nlm.nih.gov/40884870/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,38977202,Quantitative Phosphoproteomic Profiling of Mouse Sperm Maturation in Epididymis Revealed Kinases Important for Sperm Motility.,2024,10.1016/j.mcpro.2024.100810,https://pubmed.ncbi.nlm.nih.gov/38977202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,37550055,Expression of Testis-specific Serine/Threonine Kinases during the Reproductive and Nonreproductive Seasons and Their Localization in Mature Spermatozoa of Tree Shrews (Tupaia belangeri).,2023,10.30802/aalas-cm-23-000043,https://pubmed.ncbi.nlm.nih.gov/37550055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,32046715,"Effects of Qilin pills on spermatogenesis, reproductive hormones, oxidative stress, and the TSSK2 gene in a rat model of oligoasthenospermia.",2020,10.1186/s12906-019-2799-7,https://pubmed.ncbi.nlm.nih.gov/32046715/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,32337545,Testis-specific serine kinase protein family in male fertility and as targets for non-hormonal male contraception†.,2020,10.1093/biolre/ioaa064,https://pubmed.ncbi.nlm.nih.gov/32337545/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,33765466,"cDNA cloning, expression and bioinformatical analysis of Tssk genes in tree shrews.",2021,10.1016/j.compbiolchem.2021.107474,https://pubmed.ncbi.nlm.nih.gov/33765466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,34041241,Long Noncoding RNA lnc-TSSK2-8 Activates Canonical Wnt/β-Catenin Signaling Through Small Heat Shock Proteins HSPA6 and CRYAB.,2021,10.3389/fcell.2021.660576,https://pubmed.ncbi.nlm.nih.gov/34041241/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,34623009,"TSSK3, a novel target for male contraception, is required for spermiogenesis.",2021,10.1002/mrd.23539,https://pubmed.ncbi.nlm.nih.gov/34623009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,39358566,Comprehensive analysis of chromosomal breakpoints and candidate genes associated with male infertility: insights from cytogenetic studies and expression analyses.,2024,10.1007/s00335-024-10074-z,https://pubmed.ncbi.nlm.nih.gov/39358566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,37286946,Multi-omics analysis reveals changes in tryptophan and cholesterol metabolism before and after sexual maturation in captive macaques.,2023,10.1186/s12864-023-09404-3,https://pubmed.ncbi.nlm.nih.gov/37286946/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,36181097,Association between chromosome 22q11.2 translocation and male oligozoospermia.,2022,10.1097/md.0000000000030790,https://pubmed.ncbi.nlm.nih.gov/36181097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,28952188,Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinase 2 (TSSK2).,2017,10.1002/cmdc.201700503,https://pubmed.ncbi.nlm.nih.gov/28952188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,26777341,Recombinant production of enzymatically active male contraceptive drug target hTSSK2 - Localization of the TSKS domain phosphorylated by TSSK2.,2016,10.1016/j.pep.2016.01.009,https://pubmed.ncbi.nlm.nih.gov/26777341/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,30697164,Transcriptomic Analysis Reveals Insights on Male Infertility in Octopus maya Under Chronic Thermal Stress.,2018,10.3389/fphys.2018.01920,https://pubmed.ncbi.nlm.nih.gov/30697164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,38357357,Signatures of selection in Mulinia lateralis underpinning its rapid adaptation to laboratory conditions.,2024,10.1111/eva.13657,https://pubmed.ncbi.nlm.nih.gov/38357357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,26600552,"Cloning, sequence characterization, and expression patterns of members of the porcine TSSK family.",2015,10.4238/2015.october.18.56,https://pubmed.ncbi.nlm.nih.gov/26600552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,30028096,Analysis of Gene Expression in Mice Testes Exposed to 1.765 GHz Microwave in Utero.,2017,,https://pubmed.ncbi.nlm.nih.gov/30028096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,23599433,"Heat shock protein 90 functions to stabilize and activate the testis-specific serine/threonine kinases, a family of kinases essential for male fertility.",2013,10.1074/jbc.m112.400978,https://pubmed.ncbi.nlm.nih.gov/23599433/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,20729278,Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis.,2011,10.1093/molehr/gaq071,https://pubmed.ncbi.nlm.nih.gov/20729278/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,18533145,Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency.,2008,10.1016/j.ydbio.2008.03.047,https://pubmed.ncbi.nlm.nih.gov/18533145/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK2,ENSG00000206203,Neither,15044604,Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm.,2004,10.1093/molehr/gah052,https://pubmed.ncbi.nlm.nih.gov/15044604/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,41764189,Doublet microtubule-associated tektins and enzymes differentially regulate sperm flagellar integrity and motility.,2026,10.1038/s41467-026-69714-4,https://pubmed.ncbi.nlm.nih.gov/41764189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,40570569,Tssk6 is essential for the regulation of male zebrafish fertility.,2025,10.1016/j.theriogenology.2025.117547,https://pubmed.ncbi.nlm.nih.gov/40570569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,40644780,High temperature induces reproductive dysfunction in male zebrafish via DNA methylation-mediated tssk6 downregulation.,2025,10.1016/j.ecoenv.2025.118650,https://pubmed.ncbi.nlm.nih.gov/40644780/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,38762178,Testis-specific serine kinase 6 (TSSK6) is abnormally expressed in colorectal cancer and promotes oncogenic behaviors.,2024,10.1016/j.jbc.2024.107380,https://pubmed.ncbi.nlm.nih.gov/38762178/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,40305308,Identification of TSSK1 and TSSK2 as Novel Targets for Male Contraception.,2025,10.3390/biom15040601,https://pubmed.ncbi.nlm.nih.gov/40305308/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,37227814,Identification and validation of diagnostic signature genes in non-obstructive azoospermia by machine learning.,2023,10.18632/aging.204749,https://pubmed.ncbi.nlm.nih.gov/37227814/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,37550055,Expression of Testis-specific Serine/Threonine Kinases during the Reproductive and Nonreproductive Seasons and Their Localization in Mature Spermatozoa of Tree Shrews (Tupaia belangeri).,2023,10.30802/aalas-cm-23-000043,https://pubmed.ncbi.nlm.nih.gov/37550055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,40496862,Integrative genomic and single-cell framework identifies druggable targets for colorectal cancer precision therapy.,2025,10.3389/fimmu.2025.1604154,https://pubmed.ncbi.nlm.nih.gov/40496862/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,38714941,Characterization of sexual maturity-associated N6-methyladenosine in boar testes.,2024,10.1186/s12864-024-10343-w,https://pubmed.ncbi.nlm.nih.gov/38714941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,39918628,Identifying potential drug targets for seborrheic keratosis through druggable genome-wide Mendelian randomization and colocalization analysis.,2025,10.1007/s00403-025-03875-y,https://pubmed.ncbi.nlm.nih.gov/39918628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,40495716,Live-cell GLUT4 translocation assay reveals Per3 as a novel regulator of circadian insulin sensitivity in skeletal muscle cells.,2025,10.1242/bio.061941,https://pubmed.ncbi.nlm.nih.gov/40495716/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,39110588,Identification of Potential Drug Targets for Myopia Through Mendelian Randomization.,2024,10.1167/iovs.65.10.13,https://pubmed.ncbi.nlm.nih.gov/39110588/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,37151112,Integrated testis transcriptome and whole genome analysis of sexual maturity in Large White and Tongcheng pigs.,2023,10.1111/rda.14373,https://pubmed.ncbi.nlm.nih.gov/37151112/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,32337545,Testis-specific serine kinase protein family in male fertility and as targets for non-hormonal male contraception†.,2020,10.1093/biolre/ioaa064,https://pubmed.ncbi.nlm.nih.gov/32337545/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,33765466,"cDNA cloning, expression and bioinformatical analysis of Tssk genes in tree shrews.",2021,10.1016/j.compbiolchem.2021.107474,https://pubmed.ncbi.nlm.nih.gov/33765466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,34623009,"TSSK3, a novel target for male contraception, is required for spermiogenesis.",2021,10.1002/mrd.23539,https://pubmed.ncbi.nlm.nih.gov/34623009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,33859575,Expression of the Testis-Specific Serine/Threonine Kinases Suggests Their Role in Spermiogenesis of Bay Scallop Argopecten irradians.,2021,10.3389/fphys.2021.657559,https://pubmed.ncbi.nlm.nih.gov/33859575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,31009948,Targeted knock-in mice with a human mutation in GRTH/DDX25 reveals the essential role of phosphorylated GRTH in spermatid development during spermatogenesis.,2019,10.1093/hmg/ddz079,https://pubmed.ncbi.nlm.nih.gov/31009948/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,38370172,Relaminarization of jet impingement on a flat plate using separation-induced transition correction turbulence modeling preliminarily applied in archeological applications.,2024,10.1016/j.heliyon.2024.e26040,https://pubmed.ncbi.nlm.nih.gov/38370172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,32452127,An approach using Caenorhabditis elegans screening novel targets to suppress tumour cell proliferation.,2020,10.1111/cpr.12832,https://pubmed.ncbi.nlm.nih.gov/32452127/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,27240091,Landscape of tumor-infiltrating T cell repertoire of human cancers.,2016,10.1038/ng.3581,https://pubmed.ncbi.nlm.nih.gov/27240091/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,34537014,KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases.,2021,10.1186/s12859-021-04358-3,https://pubmed.ncbi.nlm.nih.gov/34537014/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,29785346,Integrated bioinformatic changes and analysis of retina with time in diabetic rats.,2018,10.7717/peerj.4762,https://pubmed.ncbi.nlm.nih.gov/29785346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK6,ENSG00000178093,Neither,15870294,"Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility.",2005,10.1128/mcb.25.10.4250-4261.2005,https://pubmed.ncbi.nlm.nih.gov/15870294/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL2,ENSG00000120440,Neither,41401204,The loss of a supergene in obligately polygynous Formica wood ant species.,2025,10.1093/molbev/msaf320,https://pubmed.ncbi.nlm.nih.gov/41401204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL2,ENSG00000120440,Neither,41909960,Genetic Parameters and Genome-Wide Association Studies for Fertility and Reproduction Traits in U.S. Katahdin Sheep Based on the Single-Step GBLUP Methodology.,2026,10.1111/jbg.70048,https://pubmed.ncbi.nlm.nih.gov/41909960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL2,ENSG00000120440,Neither,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL2,ENSG00000120440,Neither,39920028,Characterization of tubulin post-translational modifications and their enzymes during human oocyte meiosis.,2025,10.1016/j.rbmo.2024.103885,https://pubmed.ncbi.nlm.nih.gov/39920028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL2,ENSG00000120440,Neither,26430897,Family-Based Association Study of Pulmonary Function in a Population in Northeast Asia.,2015,10.1371/journal.pone.0139716,https://pubmed.ncbi.nlm.nih.gov/26430897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL8,ENSG00000138892,Neither,39891409,"Identification of TTLL8, POTEE, and PKMYT1 as immunogenic cancer-associated antigens and potential immunotherapy targets in ovarian cancer.",2025,10.1080/2162402x.2025.2460276,https://pubmed.ncbi.nlm.nih.gov/39891409/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL8,ENSG00000138892,Neither,40564006,Effect of Recombinant Human Growth Hormone (rhGH) Use on Genetic Methylation Patterns and Their Relationship with Body Composition in Small-for-Gestational-Age (SGA) Newborns.,2025,10.3390/biomedicines13061288,https://pubmed.ncbi.nlm.nih.gov/40564006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL8,ENSG00000138892,Neither,25180231,"Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon.",2014,10.15252/embj.201488466,https://pubmed.ncbi.nlm.nih.gov/25180231/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL8,ENSG00000138892,Neither,23897886,Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia.,2013,10.1083/jcb.201305041,https://pubmed.ncbi.nlm.nih.gov/23897886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL8,ENSG00000138892,Neither,19427864,TTLL10 can perform tubulin glycylation when co-expressed with TTLL8.,2009,10.1016/j.febslet.2009.05.003,https://pubmed.ncbi.nlm.nih.gov/19427864/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3C,ENSG00000198033,Neither,40649876,Age-Associated Proteomic Changes in Human Spermatozoa.,2025,10.3390/ijms26136099,https://pubmed.ncbi.nlm.nih.gov/40649876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3C,ENSG00000198033,Neither,40875626,Machine learning-based identification of diagnostic and prognostic mitotic cell cycle genes in hepatocellular carcinoma.,2025,10.1371/journal.pone.0331118,https://pubmed.ncbi.nlm.nih.gov/40875626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3C,ENSG00000198033,Neither,38073178,"Genome sequencing of Pakistani families with male infertility identifies deleterious genotypes in SPAG6, CCDC9, TKTL1, TUBA3C, and M1AP.",2025,10.1111/andr.13570,https://pubmed.ncbi.nlm.nih.gov/38073178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3C,ENSG00000198033,Neither,24268707,Acetylated α-tubulin is reduced in individuals with poor sperm motility.,2014,10.1016/j.fertnstert.2013.09.016,https://pubmed.ncbi.nlm.nih.gov/24268707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3C,ENSG00000198033,Neither,30423812,Role of Overexpressed Transcription Factor FOXO1 in Fatal Cardiovascular Septal Defects in Patau Syndrome: Molecular and Therapeutic Strategies.,2018,10.3390/ijms19113547,https://pubmed.ncbi.nlm.nih.gov/30423812/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3C,ENSG00000198033,Neither,25520250,Epigenetic patterns in successful weight loss maintainers: a pilot study.,2015,10.1038/ijo.2014.213,https://pubmed.ncbi.nlm.nih.gov/25520250/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3C,ENSG00000198033,Neither,27171184,Genome-Wide Association Study Identifies Novel Susceptibility Genes Associated with Coronary Artery Aneurysm Formation in Kawasaki Disease.,2016,10.1371/journal.pone.0154943,https://pubmed.ncbi.nlm.nih.gov/27171184/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3C,ENSG00000198033,Neither,29051577,De novo mutations of TUBA3D are associated with keratoconus.,2017,10.1038/s41598-017-13162-0,https://pubmed.ncbi.nlm.nih.gov/29051577/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLNL,ENSG00000175518,Neither,40135319,Construction and Value Analysis of a Prognostic Assessment Model Based on Radiomics and Genetic Data for Colorectal Cancer.,2025,10.12968/hmed.2024.0620,https://pubmed.ncbi.nlm.nih.gov/40135319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLNL,ENSG00000175518,Neither,36980830,Effect of Dietetic Obesity on Testicular Transcriptome in Cynomolgus Monkeys.,2023,10.3390/genes14030557,https://pubmed.ncbi.nlm.nih.gov/36980830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLNL,ENSG00000175518,Neither,37444499,UBQLN Family Members Regulate MYC in Lung Adenocarcinoma Cells.,2023,10.3390/cancers15133389,https://pubmed.ncbi.nlm.nih.gov/37444499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLNL,ENSG00000175518,Neither,26043068,"A testis-specific gene, Ubqlnl, is dispensable for mouse embryonic development and spermatogenesis.",2015,10.1002/mrd.22504,https://pubmed.ncbi.nlm.nih.gov/26043068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLNL,ENSG00000175518,Neither,35063704,Towards a molecular understanding of the overlapping and distinct roles of UBQLN1 and UBQLN2 in lung cancer progression and metastasis.,2022,10.1016/j.neo.2021.11.010,https://pubmed.ncbi.nlm.nih.gov/35063704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLNL,ENSG00000175518,Neither,24674348,The ubiquilin gene family: evolutionary patterns and functional insights.,2014,10.1186/1471-2148-14-63,https://pubmed.ncbi.nlm.nih.gov/24674348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLNL,ENSG00000175518,Neither,22871458,Genotype×age interaction in human transcriptional ageing.,2012,10.1016/j.mad.2012.07.005,https://pubmed.ncbi.nlm.nih.gov/22871458/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBQLNL,ENSG00000175518,Neither,22923468,Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.,2012,10.2337/db11-0550,https://pubmed.ncbi.nlm.nih.gov/22923468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UMODL1,ENSG00000177398,Neither,41859171,Early non-invasive epigenetic approach for assessing trisomy risk in maternal plasma.,2026,10.3389/fmed.2026.1704017,https://pubmed.ncbi.nlm.nih.gov/41859171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UMODL1,ENSG00000177398,Neither,37570259,Genomic Prediction and Genome-Wide Association Study for Boar Taint Compounds.,2023,10.3390/ani13152450,https://pubmed.ncbi.nlm.nih.gov/37570259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UMODL1,ENSG00000177398,Neither,35223856,Anosmin-1-Like Effect of UMODL1/Olfactorin on the Chemomigration of Mouse GnRH Neurons and Zebrafish Olfactory Axons Development.,2022,10.3389/fcell.2022.836179,https://pubmed.ncbi.nlm.nih.gov/35223856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UMODL1,ENSG00000177398,Neither,39412438,The clinical and genetic spectrum of paediatric speech and language disorders.,2025,10.1093/brain/awae264,https://pubmed.ncbi.nlm.nih.gov/39412438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UMODL1,ENSG00000177398,Neither,35441736,Differential expression and analysis of extrachromosomal circular DNAs as serum biomarkers in lung adenocarcinoma.,2022,10.1002/jcla.24425,https://pubmed.ncbi.nlm.nih.gov/35441736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UMODL1,ENSG00000177398,Neither,35847359,Construction of a Novel MYC-Associated ceRNA Regulatory Network to Identify Prognostic Biomarkers in Colon Adenocarcinoma.,2022,10.1155/2022/3216285,https://pubmed.ncbi.nlm.nih.gov/35847359/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UMODL1,ENSG00000177398,Neither,35305102,Toripalimab Plus Paclitaxel and Carboplatin as Neoadjuvant Therapy in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma.,2022,10.1093/oncolo/oyab011,https://pubmed.ncbi.nlm.nih.gov/35305102/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UMODL1,ENSG00000177398,Neither,23190605,Overexpression of Uromodulin-like1 accelerates follicle depletion and subsequent ovarian degeneration.,2012,10.1038/cddis.2012.169,https://pubmed.ncbi.nlm.nih.gov/23190605/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UMODL1,ENSG00000177398,Neither,26942882,Long non-coding RNAs as prognostic markers in human breast cancer.,2016,10.18632/oncotarget.7828,https://pubmed.ncbi.nlm.nih.gov/26942882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UMODL1,ENSG00000177398,Neither,26828653,Genomic Alteration During Metastasis of Lung Adenocarcinoma.,2016,10.1159/000438644,https://pubmed.ncbi.nlm.nih.gov/26828653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UMODL1,ENSG00000177398,Neither,15194491,Initial characterization of an uromodulin-like 1 gene on human chromosome 21q22.3.,2004,10.1016/j.bbrc.2004.05.094,https://pubmed.ncbi.nlm.nih.gov/15194491/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UMODL1,ENSG00000177398,Neither,16026467,UMODL1/Olfactorin is an extracellular membrane-bound molecule with a restricted spatial expression in olfactory and vomeronasal neurons.,2005,10.1111/j.1460-9568.2005.04164.x,https://pubmed.ncbi.nlm.nih.gov/16026467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UMODL1,ENSG00000177398,Neither,22857148,Investigating the relationship between UMODL1 gene polymorphisms and high myopia: a case-control study in Chinese.,2012,10.1186/1471-2350-13-64,https://pubmed.ncbi.nlm.nih.gov/22857148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UMODL1,ENSG00000177398,Neither,20692344,Uncx regulates proliferation of neural progenitor cells and neuronal survival in the olfactory epithelium.,2010,10.1016/j.mcn.2010.07.013,https://pubmed.ncbi.nlm.nih.gov/20692344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UMODL1,ENSG00000177398,Neither,18535602,New susceptibility locus for high myopia is linked to the uromodulin-like 1 (UMODL1) gene region on chromosome 21q22.3.,2009,10.1038/eye.2008.152,https://pubmed.ncbi.nlm.nih.gov/18535602/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UMODL1,ENSG00000177398,Neither,36756739,Epigenome alterations in food allergy: A systematic review of candidate gene and epigenome-wide association studies.,2023,10.1111/cea.14277,https://pubmed.ncbi.nlm.nih.gov/36756739/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,42580561,CDK1 regulates NRF2 stability through phosphorylation of USP29 and inhibits neuronal ferroptosis after traumatic brain injury.,2026,10.1016/j.brainresbull.2026.112067,https://pubmed.ncbi.nlm.nih.gov/42580561/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,42125859,USP29-regulated noncanonical stabilization of the hypoxia-inducible factor-α in aggressive prostate cancer.,2026,10.1002/1878-0261.70268,https://pubmed.ncbi.nlm.nih.gov/42125859/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,40634288,ELAVL1-mediated USP29 mRNA degradation activates TAK1 driving M1 microglial polarization and neural stem cell differentiation dysregulation in spinal cord injury.,2025,10.1038/s41420-025-02604-8,https://pubmed.ncbi.nlm.nih.gov/40634288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,41387682,USP29 and SMURF1 orchestrate FSP1-mediated ferroptosis suppression to facilitate chemoresistance in gastric cancer.,2025,10.1038/s41467-025-66319-1,https://pubmed.ncbi.nlm.nih.gov/41387682/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,40040611,Deubiquitinase Ubiquitin-Specific Protease 29 Ameliorates Pathological Cardiac Hypertrophy through Inhibiting Transforming Growth Factor β-Activated Kinase 1.,2025,10.1161/jaha.124.034962,https://pubmed.ncbi.nlm.nih.gov/40040611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,39355870,USP29 alleviates the progression of MASLD by stabilizing ACSL5 through K48 deubiquitination.,2025,10.3350/cmh.2024.0478,https://pubmed.ncbi.nlm.nih.gov/39355870/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,39501572,"Stabilizing hepatic fatty acid oxidation: Editorial on ""USP29 alleviates the progression of MASLD by stabilizing ACSL5 through K48 deubiquitination"".",2025,10.3350/cmh.2024.0971,https://pubmed.ncbi.nlm.nih.gov/39501572/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,38233848,USP29 activation mediated by FUBP1 promotes AURKB stability and oncogenic functions in gastric cancer.,2024,10.1186/s12935-024-03224-5,https://pubmed.ncbi.nlm.nih.gov/38233848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,36628242,Deubiquitinase USP29 correlates RORγt expression and its association with thymoma myasthenia gravis.,2022,,https://pubmed.ncbi.nlm.nih.gov/36628242/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,36373629,Promotive role of USP29-mediated deubiquitination in malignant proliferation of colorectal cancer cells via the KIAA1429/SOX8 axis.,2023,10.17305/bjbms.2022.7930,https://pubmed.ncbi.nlm.nih.gov/36373629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,40818063,Inhibition of UBE2N promotes the clearance of mutant HTT (huntingtin) in HD knock-in mice.,2025,10.1080/15548627.2025.2549109,https://pubmed.ncbi.nlm.nih.gov/40818063/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,37304282,Ubiquitin-specific protease 29 attenuates hepatic ischemia-reperfusion injury by mediating TGF-β-activated kinase 1 deubiquitination.,2023,10.3389/fimmu.2023.1167667,https://pubmed.ncbi.nlm.nih.gov/37304282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,37463886,Identification of USP29 as a key regulator of nucleotide biosynthesis in neuroblastoma through integrative analysis of multi-omics data.,2023,10.1080/15384047.2023.2237200,https://pubmed.ncbi.nlm.nih.gov/37463886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,39562695,CEACAM6 facilitates gastric cancer progression through upregulating SLC27A2.,2025,10.1038/s41417-024-00846-9,https://pubmed.ncbi.nlm.nih.gov/39562695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,41838919,Active maintenance of meiosis-specific chromosome structures in &lt;i&gt;Caenorhabditis elegans&lt;/i&gt; by the deubiquitinase DUO-1.,2026,10.1073/pnas.2532671123,https://pubmed.ncbi.nlm.nih.gov/41838919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,36782089,Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions.,2023,10.1002/advs.202205873,https://pubmed.ncbi.nlm.nih.gov/36782089/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,34824671,Ubiquitin-Specific Protease 29 Exacerbates Cerebral Ischemia-Reperfusion Injury in Mice.,2021,10.1155/2021/6955628,https://pubmed.ncbi.nlm.nih.gov/34824671/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,36010569,USP29 Deubiquitinates SETD8 and Regulates DNA Damage-Induced H4K20 Monomethylation and 53BP1 Focus Formation.,2022,10.3390/cells11162492,https://pubmed.ncbi.nlm.nih.gov/36010569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,34072621,Ubiquitin Specific Protease 29 Functions as an Oncogene Promoting Tumorigenesis in Colorectal Carcinoma.,2021,10.3390/cancers13112706,https://pubmed.ncbi.nlm.nih.gov/34072621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,35638730,The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9b.,2022,10.1128/mbio.01300-22,https://pubmed.ncbi.nlm.nih.gov/35638730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,31878357,Deubiquitinase USP29 Governs MYBBP1A in the Brains of Parkinson's Disease Patients.,2019,10.3390/jcm9010052,https://pubmed.ncbi.nlm.nih.gov/31878357/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,21636974,Effects of endocrine disruptors on imprinted gene expression in the mouse embryo.,2011,10.4161/epi.6.7.16067,https://pubmed.ncbi.nlm.nih.gov/21636974/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP29,ENSG00000131864,Neither,18166131,MacroH2A1 knockdown effects on the Peg3 imprinted domain.,2007,10.1186/1471-2164-8-479,https://pubmed.ncbi.nlm.nih.gov/18166131/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP50,ENSG00000170236,Neither,40702108,Interfering with USP50 expression inhibits macrophage pyroptosis in sepsis-induced acute lung injury by degrading NLRP3 protein.,2025,10.1038/s41598-025-11224-2,https://pubmed.ncbi.nlm.nih.gov/40702108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP50,ENSG00000170236,Neither,41404189,USP50-mediated NLRP3 deubiquitination enhances NLRP3 inflammasome activation to suppress HCC metastasis.,2025,10.1016/j.jpha.2025.101380,https://pubmed.ncbi.nlm.nih.gov/41404189/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP50,ENSG00000170236,Neither,39284827,USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication.,2024,10.1038/s41467-024-52250-4,https://pubmed.ncbi.nlm.nih.gov/39284827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP50,ENSG00000170236,Neither,38469295,USP50 regulates NLRP3 inflammasome activation in duodenogastric reflux-induced gastric tumorigenesis.,2024,10.3389/fimmu.2024.1326137,https://pubmed.ncbi.nlm.nih.gov/38469295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP50,ENSG00000170236,Neither,37608279,ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification.,2023,10.1186/s12929-023-00965-9,https://pubmed.ncbi.nlm.nih.gov/37608279/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP50,ENSG00000170236,Neither,37647255,Pristimerin suppresses AIM2 inflammasome by modulating AIM2-PYCARD/ASC stability via selective autophagy to alleviate tendinopathy.,2024,10.1080/15548627.2023.2249392,https://pubmed.ncbi.nlm.nih.gov/37647255/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP50,ENSG00000170236,Neither,36876523,Vitamin C promotes ACE2 degradation and protects against SARS-CoV-2 infection.,2023,10.15252/embr.202256374,https://pubmed.ncbi.nlm.nih.gov/36876523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP50,ENSG00000170236,Neither,34976224,Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation.,2022,10.7150/thno.63751,https://pubmed.ncbi.nlm.nih.gov/34976224/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP50,ENSG00000170236,Neither,38203295,Genome-Wide Association Analysis of Heat Tolerance in F2 Progeny from the Hybridization between Two Congeneric Oyster Species.,2023,10.3390/ijms25010125,https://pubmed.ncbi.nlm.nih.gov/38203295/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP50,ENSG00000170236,Neither,29101126,Induction of deubiquitinating enzyme USP50 during erythropoiesis and its potential role in the regulation of Ku70 stability.,2018,10.1136/jim-2017-000622,https://pubmed.ncbi.nlm.nih.gov/29101126/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP50,ENSG00000170236,Neither,28094437,"The deubiquitinating enzyme, ubiquitin-specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein.",2017,10.1002/1873-3468.12558,https://pubmed.ncbi.nlm.nih.gov/28094437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP50,ENSG00000170236,Neither,27182066,Differential Expression Profiles of Long Noncoding RNA and mRNA of Osteogenically Differentiated Mesenchymal Stem Cells in Ankylosing Spondylitis.,2016,10.3899/jrheum.151181,https://pubmed.ncbi.nlm.nih.gov/27182066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP50,ENSG00000170236,Neither,14715245,Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.,2004,10.1016/j.bbrc.2003.12.050,https://pubmed.ncbi.nlm.nih.gov/14715245/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VN1R4,ENSG00000228567,Neither,27006382,Gene expression profiling in undifferentiated thyroid carcinoma induced by high-dose radiation.,2016,10.1093/jrr/rrw002,https://pubmed.ncbi.nlm.nih.gov/27006382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VN1R4,ENSG00000228567,Neither,23451178,Distinct genomic aberrations between low-grade and high-grade gliomas of Chinese patients.,2013,10.1371/journal.pone.0057168,https://pubmed.ncbi.nlm.nih.gov/23451178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VN1R5,ENSG00000197617,Neither,39912936,HSV-1 inhibits melanogenesis of PIG1 cells through downregulation of VN1R5/ERK pathway.,2025,10.1007/s00403-025-03844-5,https://pubmed.ncbi.nlm.nih.gov/39912936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VN1R5,ENSG00000197617,Neither,34111560,lncRNA lnc-POP1-1 upregulated by VN1R5 promotes cisplatin resistance in head and neck squamous cell carcinoma through interaction with MCM5.,2022,10.1016/j.ymthe.2021.06.006,https://pubmed.ncbi.nlm.nih.gov/34111560/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VN1R5,ENSG00000197617,Neither,25797832,The smelling of Hedione results in sex-differentiated human brain activity.,2015,10.1016/j.neuroimage.2015.03.029,https://pubmed.ncbi.nlm.nih.gov/25797832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,41150076,Functional Mutations in the &lt;i&gt;VRTN&lt;/i&gt; Gene Influence Growth Traits and Meat Quality in Hainan Black Goats.,2025,10.3390/vetsci12100936,https://pubmed.ncbi.nlm.nih.gov/41150076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,41846292,Multi-stage transcriptomic analysis of mouse embryonic lethality induced by homozygous knockout of the &lt;i&gt;Vrtn&lt;/i&gt; gene.,2026,10.16288/j.yczz.25-190,https://pubmed.ncbi.nlm.nih.gov/41846292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,41261143,Identification of novel vertebral development factors through UK Biobank candidate gene search and body imaging analysis.,2025,10.1038/s42003-025-09021-8,https://pubmed.ncbi.nlm.nih.gov/41261143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,41463911,Integrative Multi-Omics Analysis Unveils Candidate Genes and Functional Variants for Growth and Reproductive Traits in Duroc Pigs.,2025,10.3390/ani15243627,https://pubmed.ncbi.nlm.nih.gov/41463911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,42655796,Genome-Wide Association Study of Rib Number and Total Thoracolumbar Vertebrae Number in a Jishen Black Pig Population.,2026,10.3390/vetsci13080776,https://pubmed.ncbi.nlm.nih.gov/42655796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,41418786,Genetic screening of long non-coding RNAs in human embryonic stem cells reveals novel regulators of pluripotency.,2026,10.1016/j.stemcr.2025.102743,https://pubmed.ncbi.nlm.nih.gov/41418786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,39177846,Epigenetic and genetic risk of Alzheimer disease from autopsied brains in two ethnic groups.,2024,10.1007/s00401-024-02778-y,https://pubmed.ncbi.nlm.nih.gov/39177846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,41751417,"Genes and Gene Functions Associated with Morphological, Productive, Reproductive, and Carcass Quality Traits in Pigs: A Functional Bioinformatics Approach.",2026,10.3390/cimb48020153,https://pubmed.ncbi.nlm.nih.gov/41751417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,42214138,Cross-population meta-analysis and colocalisation analysis reveal novel and pleiotropic genes associated with rib and teat number in pigs.,2026,10.1016/j.animal.2026.101836,https://pubmed.ncbi.nlm.nih.gov/42214138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,38764031,ABCD4 is associated with mammary gland development in mammals.,2024,10.1186/s12864-024-10398-9,https://pubmed.ncbi.nlm.nih.gov/38764031/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,41881026,Genome-wide detection of human 5' UTR variants that impact protein translation.,2026,10.1016/j.ajhg.2026.02.020,https://pubmed.ncbi.nlm.nih.gov/41881026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,39210812,Understanding molecular mechanisms of vertebral number of variations on Mongolian sheep using candidate genes analysis.,2025,10.5713/ab.24.0212,https://pubmed.ncbi.nlm.nih.gov/39210812/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,40906455,A Genome-Wide Association Study of Rib Number and Thoracolumbar Vertebra Number in a Landrace × Yorkshire Crossbred Pig Population.,2025,10.3390/biology14081068,https://pubmed.ncbi.nlm.nih.gov/40906455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,37652983,"Young SINEs in pig genomes impact gene regulation, genetic diversity, and complex traits.",2023,10.1038/s42003-023-05234-x,https://pubmed.ncbi.nlm.nih.gov/37652983/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,40740300,Potential candidate genes influencing meat production phenotypic traits in sheep: a review.,2025,10.3389/fvets.2025.1616533,https://pubmed.ncbi.nlm.nih.gov/40740300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,37194006,Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice.,2023,10.1186/s12958-023-01097-3,https://pubmed.ncbi.nlm.nih.gov/37194006/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,39722798,Selection signature analysis reveals genes associated with tail phenotype in sheep.,2024,10.3389/fgene.2024.1509177,https://pubmed.ncbi.nlm.nih.gov/39722798/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,39810085,Genome-wide association study identifies candidate genes affecting body conformation traits of Zhongwei goat.,2025,10.1186/s12864-024-11097-1,https://pubmed.ncbi.nlm.nih.gov/39810085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,37889833,Genome-Wide Association Study Identifies the Crucial Candidate Genes for Teat Number in Crossbred Commercial Pigs.,2023,10.3390/ani13111880,https://pubmed.ncbi.nlm.nih.gov/37889833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,39695943,Revealing genes related teat number traits via genetic variation in Yorkshire pigs based on whole-genome sequencing.,2024,10.1186/s12864-024-11109-0,https://pubmed.ncbi.nlm.nih.gov/39695943/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VRTN,ENSG00000133980,Neither,36319564,Identification of marker genes to monitor residual iPSCs in iPSC-derived products.,2023,10.1016/j.jcyt.2022.09.010,https://pubmed.ncbi.nlm.nih.gov/36319564/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR88,ENSG00000166359,Neither,36167494,Genome-wide association analyses of common infections in a large practice-based biobank.,2022,10.1186/s12864-022-08888-9,https://pubmed.ncbi.nlm.nih.gov/36167494/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR88,ENSG00000166359,Neither,26740555,Exome arrays capture polygenic rare variant contributions to schizophrenia.,2016,10.1093/hmg/ddv620,https://pubmed.ncbi.nlm.nih.gov/26740555/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC9,ENSG00000180205,Neither,39665756,Large-scale CRISPR/Cas9 deletions within the WFDC gene cluster uncover gene functionality and critical roles in mammalian reproduction.,2024,10.1073/pnas.2413195121,https://pubmed.ncbi.nlm.nih.gov/39665756/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC9,ENSG00000180205,Neither,35211476,Anatomical Transcriptome Atlas of the Male Mouse Reproductive System During Aging.,2021,10.3389/fcell.2021.782824,https://pubmed.ncbi.nlm.nih.gov/35211476/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC9,ENSG00000180205,Neither,37847080,[Delivery of epididymis-specific mRNAs from mouse epididymosomes into N2a and TM4 cells].,2023,,https://pubmed.ncbi.nlm.nih.gov/37847080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC9,ENSG00000180205,Neither,27368750,Potential confounding factors in measurement of specific cell-free seminal mRNAs and microRNAs derived from human reproductive organs.,2016,10.1111/andr.12238,https://pubmed.ncbi.nlm.nih.gov/27368750/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XKR3,ENSG00000172967,Neither,37227814,Identification and validation of diagnostic signature genes in non-obstructive azoospermia by machine learning.,2023,10.18632/aging.204749,https://pubmed.ncbi.nlm.nih.gov/37227814/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XKR3,ENSG00000172967,Neither,38002954,Genome-Wide Association Analysis across Endophenotypes in Alzheimer's Disease: Main Effects and Disease Stage-Specific Interactions.,2023,10.3390/genes14112010,https://pubmed.ncbi.nlm.nih.gov/38002954/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XKR3,ENSG00000172967,Neither,35175984,The Clinical Features and Molecular Mechanism of Pituitary Adenoma Associated With Vestibular Schwannoma.,2022,10.1097/scs.0000000000008528,https://pubmed.ncbi.nlm.nih.gov/35175984/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XKR3,ENSG00000172967,Neither,25120641,NUP214 fusion genes in acute leukemia (Review).,2014,10.3892/ol.2014.2263,https://pubmed.ncbi.nlm.nih.gov/25120641/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XKR3,ENSG00000172967,Neither,16431037,"Identification of two new members, XPLAC and XTES, of the XK family.",2006,10.1016/j.gene.2005.10.037,https://pubmed.ncbi.nlm.nih.gov/16431037/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,42794493,"Beyond Shedding: Conserved Retention of ZAN After the Acrosome Reaction Across Rabbit, Boar, and Bull Sperm.",2026,10.3390/ijms27188062,https://pubmed.ncbi.nlm.nih.gov/42794493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,42784288,"Toxicokinetics, Biotransformation, Excretion, and Tissue Residue of Zearalenone-14-Glucoside in Male Sheep.",2026,10.3390/toxins18090364,https://pubmed.ncbi.nlm.nih.gov/42784288/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,41047944,Brutons tyrosine kinase inhibitor Zanubrutinib modulates Fc gamma receptors to inhibit platelet destruction for alleviation of refractory immune thrombocytopenia.,2025,10.1080/16078454.2025.2545078,https://pubmed.ncbi.nlm.nih.gov/41047944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,41859531,Developing a Core Outcome Set for Herpes Zoster-Associated Neuralgia in Clinical Trials of Traditional Chinese Medicine: A Study Protocol.,2026,10.2147/jmdh.s561192,https://pubmed.ncbi.nlm.nih.gov/41859531/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,41908125,"Paranoia, experiential avoidance, and narcissism as predictors of outcome in residential treatment of borderline personality disorder.",2026,10.3389/fpsyt.2026.1728221,https://pubmed.ncbi.nlm.nih.gov/41908125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,41183201,A multivalent nanobody-drug conjugate to prevent and treat influenza virus infections.,2025,10.1073/pnas.2409565122,https://pubmed.ncbi.nlm.nih.gov/41183201/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,38183644,"A new pepper allergen Zan b 1.01 of 2S albumins: Identification, cloning, characterization, and cross-reactivity.",2025,10.12932/ap-300423-1595,https://pubmed.ncbi.nlm.nih.gov/38183644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,41344292,A glial switch for pain-driven anxiety.,2025,10.1016/j.neuron.2025.11.008,https://pubmed.ncbi.nlm.nih.gov/41344292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,35693780,Exposed and Sequestered Antigens in Testes and Their Protection by Regulatory T Cell-Dependent Systemic Tolerance.,2022,10.3389/fimmu.2022.809247,https://pubmed.ncbi.nlm.nih.gov/35693780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,42299116,Novel bivalent mucosal antigen formulation targeting SARS-CoV-2 and influenza: immunogenicity assessment using zan in vitro human nasal-associated lymphoid tissue model.,2026,10.24425/pjvs.2026.1273,https://pubmed.ncbi.nlm.nih.gov/42299116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,38551197,"Identification, Characterization, Cloning, and Cross-Reactivity of Zan b 2, a Novel Pepper Allergen of 11S Legumin.",2024,10.1021/acs.jafc.4c00351,https://pubmed.ncbi.nlm.nih.gov/38551197/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,42070367,Neuroimaging insights into Borderline Personality Disorder patients with and without suicide attempts: A multi-modal structural MRI study.,2026,10.1016/j.jpsychires.2026.04.032,https://pubmed.ncbi.nlm.nih.gov/42070367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,42346378,Systems-Level Proteomic and Biochemical Profiling of Plasma from Captive Indian Star Tortoise with Reactome Pathway Enrichment Analysis.,2026,10.3390/metabo16060398,https://pubmed.ncbi.nlm.nih.gov/42346378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,42314478,Multi-mycotoxin biomonitoring in Italian adults: Revealing the connection between diet habits and mycotoxin exposure.,2026,10.1016/j.envint.2026.110372,https://pubmed.ncbi.nlm.nih.gov/42314478/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,39696018,Emotional processing as mechanism of change in brief good psychiatric management for borderline personality disorder: results of a randomized controlled trial.,2024,10.1186/s12888-024-06370-2,https://pubmed.ncbi.nlm.nih.gov/39696018/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,41330501,Vasoactive intestinal peptide modified defect-engineered ZnO&lt;sub&gt;x&lt;/sub&gt;-Au-NaBH&lt;sub&gt;4&lt;/sub&gt; nanoplatform inducing pyroptosis in fibroblast-like synoviocytes for therapy of rheumatoid arthritis.,2026,10.1016/j.ijbiomac.2025.149390,https://pubmed.ncbi.nlm.nih.gov/41330501/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,37148454,The extract based on the Kampo formula daikenchuto (Da Jian Zhong Tang) induces Bdnf expression and has neurotrophic effects in cultured cortical neurons.,2023,10.1007/s11418-023-01703-z,https://pubmed.ncbi.nlm.nih.gov/37148454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,37230371,"A five-day treatment course of zanamivir for the flu with a single, self-administered, painless microneedle array patch: Revolutionizing delivery of poorly membrane-permeable therapeutics.",2023,10.1016/j.ijpharm.2023.123081,https://pubmed.ncbi.nlm.nih.gov/37230371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,40451151,Change in Emotional Arousal Variance in Clients with Borderline Personality Disorder during a Brief Psychiatric Treatment.,2025,10.1159/000546284,https://pubmed.ncbi.nlm.nih.gov/40451151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,36297430,Bruton's Tyrosine Kinase Inhibitor Zanubrutinib Effectively Modulates Cancer Resistance by Inhibiting Anthracycline Metabolism and Efflux.,2022,10.3390/pharmaceutics14101994,https://pubmed.ncbi.nlm.nih.gov/36297430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,42916521,Epitope-Guided Two-Step Enzymatic Hydrolysis for Targeted Control of the Immunoreactivity of the Major Sichuan Pepper Allergen Zan b 2.,2026,10.1021/acs.jafc.6c08943,https://pubmed.ncbi.nlm.nih.gov/42916521/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,41916098,"Metabolism and excretion pathways of CD388, a novel drug-fragment crystallizable conjugate for prevention of seasonal or pandemic influenza.",2026,10.1016/j.dmd.2026.100270,https://pubmed.ncbi.nlm.nih.gov/41916098/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,41780654,Systematic review of real-world data on the effectiveness and safety profiles of first-line therapies in chronic lymphocytic leukemia.,2026,10.1016/j.critrevonc.2026.105239,https://pubmed.ncbi.nlm.nih.gov/41780654/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,42384092,"A Double-blind, Placebo-controlled Study of Lumateperone in the Treatment of Borderline Personality Disorder.",2026,10.1097/wnf.0000000000000693,https://pubmed.ncbi.nlm.nih.gov/42384092/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,39091602,Network meta-analysis of novel targeted therapies for relapsed/refractory chronic lymphocytic leukemia.,2024,10.1177/17588359241263710,https://pubmed.ncbi.nlm.nih.gov/39091602/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,39631372,"""Real-Life"" Data of Zanubrutinib in Patients with Waldenström Macroglobulinemia: A Multicenter Retrospective Study.",2025,10.1159/000542936,https://pubmed.ncbi.nlm.nih.gov/39631372/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,42458542,Follow-up effects of a brief Good Psychiatric Management treatment for borderline personality disorder.,2026,10.1186/s40479-026-00357-z,https://pubmed.ncbi.nlm.nih.gov/42458542/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,39832346,"Efficacy and Safety of BI 1358894 in Patients With Borderline Personality Disorder: Results of a Phase 2 Randomized, Placebo-Controlled, Parallel Group Dose-Ranging Trial.",2025,10.4088/jcp.24m15523,https://pubmed.ncbi.nlm.nih.gov/39832346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,42546378,Norgestrel drives mitochondrial collapse and plasma membrane impairment in Pacific oyster (Crassostrea gigas) sperm by triggering premature acrosome reaction.,2026,10.1016/j.cbd.2026.101952,https://pubmed.ncbi.nlm.nih.gov/42546378/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,41440291,Rapid On-Site Detection of Zearalenone in Maize Using a Colloidal Gold Immunochromatographic Strip.,2025,10.3390/bios15120810,https://pubmed.ncbi.nlm.nih.gov/41440291/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,38922172,Assessment of Mycotoxin Exposure and Associated Risk in Pregnant Dutch Women: The Human Biomonitoring Approach.,2024,10.3390/toxins16060278,https://pubmed.ncbi.nlm.nih.gov/38922172/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,40603907,Comparative efficacy and safety of pulsed radiofrequency versus spinal cord stimulation in thoracic herpes zoster pain: a retrospective study.,2025,10.1038/s41598-025-06289-y,https://pubmed.ncbi.nlm.nih.gov/40603907/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,41675670,Protocol for a cohort comparison treatment study evaluating the efficacy of a dimensional adaptation of GPM (GPM-extended) compared to a classic outpatient GPM treatment for patient fulfilling criteria for BPD: the EPSYLIA project.,2025,10.3389/fpsyt.2025.1687987,https://pubmed.ncbi.nlm.nih.gov/41675670/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAN,ENSG00000146839,Neither,37011037,Occurrence of zearalenone and its major metabolites in cereal flour from Korea.,2023,10.1080/19440049.2023.2195956,https://pubmed.ncbi.nlm.nih.gov/37011037/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,41420714,ZAR1 pathogenic variants disrupt maternal mRNA storage and cause oocyte maturation defects in humans.,2025,10.1007/s00018-025-06000-4,https://pubmed.ncbi.nlm.nih.gov/41420714/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,42679563,"Timeline of sex differentiation and stabilization in zebrafish: Interplay between methyl-sensitive transcription factors, prostaglandin-related genes and DNA methylation.",2026,10.1016/j.ejcb.2026.151569,https://pubmed.ncbi.nlm.nih.gov/42679563/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,42415824,Severe infantile obesity with a maternal &lt;i&gt;GNAS&lt;/i&gt; deletion and multi-locus imprinting disturbance including hypomethylation of the &lt;i&gt;KCNQ1OT1&lt;/i&gt;:TSS-DMR.,2026,10.1297/cpe.2025-0081,https://pubmed.ncbi.nlm.nih.gov/42415824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,41828362,Genetic Mutations and Non-Genomic Dysregulation in Human Preimplantation Embryo Arrest.,2026,10.3390/ijms27052135,https://pubmed.ncbi.nlm.nih.gov/41828362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,41800307,Comparative developmental competence and gene expression in laparoscopically retrieved- and abattoir-derived goat oocytes.,2026,10.3389/fvets.2026.1737059,https://pubmed.ncbi.nlm.nih.gov/41800307/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,41963568,"Evaluation of season and sex specific differential gonadal transcriptomics in Himalayan snow trout Schizothorax plagiostomus, Heckel, 1838.",2026,10.1038/s41598-026-47745-7,https://pubmed.ncbi.nlm.nih.gov/41963568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,40216655,The Regulation of ZAR1 on Apoptosis and Mitophagy in Ovarian Granular Cells and Primary Ovarian Insufficiency (POI) Mice.,2025,10.1007/s43032-025-01857-z,https://pubmed.ncbi.nlm.nih.gov/40216655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,38338151,"Characterization of Two Gonadal Genes, zar1 and wt1b, in Hermaphroditic Fish Asian Seabass (Lates calcarifer).",2024,10.3390/ani14030508,https://pubmed.ncbi.nlm.nih.gov/38338151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,40388637,Molecular insights into RNA recognition by the ZAR1 C-terminal domain.,2025,10.1002/1873-3468.70080,https://pubmed.ncbi.nlm.nih.gov/40388637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,40340906,ZAR1 and ZAR2 orchestrate the dynamics of maternal mRNA polyadenylation during mouse oocyte development.,2025,10.1186/s13059-025-03593-8,https://pubmed.ncbi.nlm.nih.gov/40340906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,40587573,Arabidopsis CNL receptor SUT1 confers immunity in hydathodes against the vascular pathogen Xanthomonas campestris pv. campestris.,2025,10.1371/journal.ppat.1013256,https://pubmed.ncbi.nlm.nih.gov/40587573/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,40721554,The E3 ubiquitin ligase adaptor KLHL8 targets ZAR1 to regulate maternal mRNA degradation in oocytes.,2025,10.1038/s44319-025-00537-y,https://pubmed.ncbi.nlm.nih.gov/40721554/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,39755931,ZAR1/2-Regulated Epigenetic Modifications are Essential for Age-Associated Oocyte Quality Maintenance and Zygotic Activation.,2025,10.1002/advs.202410305,https://pubmed.ncbi.nlm.nih.gov/39755931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,42083516,Znhit1-mediated H2A.Z deposition governs transcriptional programs essential for oocyte meiotic progression.,2026,10.1242/dev.205554,https://pubmed.ncbi.nlm.nih.gov/42083516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,41964954,Signatures of the coevolutionary arms race in response to effector-triggered immunity in the Pseudomonas syringae HopZ type III effector family.,2026,10.1016/j.celrep.2026.117247,https://pubmed.ncbi.nlm.nih.gov/41964954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,38748589,Molecular dissection of the pseudokinase ZED1 expands effector recognition to the tomato immune receptor ZAR1.,2024,10.1093/plphys/kiae268,https://pubmed.ncbi.nlm.nih.gov/38748589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,41899468,Time-Series-Based Co-Expression Network Analysis Reveals Key Regulatory Modules and Hub Genes in Salt-Tolerant Wheat Under Salt Stress.,2026,10.3390/cimb48030317,https://pubmed.ncbi.nlm.nih.gov/41899468/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,41641768,The Recognition of YopJ Family Effectors Depends on ZAR1/JIM2 Immune Complex in Nicotiana benthamiana.,2026,10.1111/mpp.70214,https://pubmed.ncbi.nlm.nih.gov/41641768/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,40749626,Differential lncRNA expression in the ovarian tissue of Wanxi white goose at different laying stages and the its mechanism of egg laying.,2025,10.1016/j.psj.2025.105597,https://pubmed.ncbi.nlm.nih.gov/40749626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,42070745,Role of zygotic arrest genes in female meiosis and early embryonic development.,2026,10.1016/j.ydbio.2026.04.019,https://pubmed.ncbi.nlm.nih.gov/42070745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,39730946,Hepatitis B virus impacts embryonic development and methylation of maternal genes in assisted reproductive technology patients.,2025,10.1007/s10815-024-03359-4,https://pubmed.ncbi.nlm.nih.gov/39730946/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,40941308,Dietary Soy Isoflavones Promote Feminization and Enhance Growth of Juvenile Japanese Eel (&lt;i&gt;Anguilla japonica&lt;/i&gt;).,2025,10.3390/ani15172513,https://pubmed.ncbi.nlm.nih.gov/40941308/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,42062216,Single-cell proteomics reveals cytoplasmic defects in Patl2-deficient oocytes rescued by spindle transfer.,2026,10.1093/humrep/deag073,https://pubmed.ncbi.nlm.nih.gov/42062216/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,36163289,A wheat resistosome defines common principles of immune receptor channels.,2022,10.1038/s41586-022-05231-w,https://pubmed.ncbi.nlm.nih.gov/36163289/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,35909688,Method to Assess Farm-Level Vaccine and Antibiotic Usage Utilizing Financial Documentation: A Pilot Study in a Commercial Pig Farm in South Africa From 2016 to 2018.,2022,10.3389/fvets.2022.856729,https://pubmed.ncbi.nlm.nih.gov/35909688/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,28130327,Insertion of inter-domain linkers improves expression and bioactivity of Zygote arrest (Zar) fusion proteins.,2017,10.1093/protein/gzx002,https://pubmed.ncbi.nlm.nih.gov/28130327/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,24787227,Evaluation of ZAR1 and SFRP4 methylation status as potentials biomarkers for diagnosis in cervical cancer: exploratory study phase I.,2014,10.3109/1354750x.2013.867535,https://pubmed.ncbi.nlm.nih.gov/24787227/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,35493980,"A review of the use of inhaled nitric oxide in the PICU at Red Cross War Memorial Children's Hospital, 2011-2015: A retrospective cohort study.",2021,10.7196/sajcc.2021.v37i2.416,https://pubmed.ncbi.nlm.nih.gov/35493980/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,32992968,In Vitro Maturation with Leukemia Inhibitory Factor Prior to the Vitrification of Bovine Oocytes Improves Their Embryo Developmental Potential and Gene Expression in Oocytes and Embryos.,2020,10.3390/ijms21197067,https://pubmed.ncbi.nlm.nih.gov/32992968/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,33692829,Genome-Scale Phylogenetic and Population Genetic Studies Provide Insight Into Introgression and Adaptive Evolution of Takifugu Species in East Asia.,2021,10.3389/fgene.2021.625600,https://pubmed.ncbi.nlm.nih.gov/33692829/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,22649508,The beneficial effects of antifreeze proteins in the vitrification of immature mouse oocytes.,2012,10.1371/journal.pone.0037043,https://pubmed.ncbi.nlm.nih.gov/22649508/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,16551357,"Zygote arrest 1 gene in pig, cattle and human: evidence of different transcript variants in male and female germ cells.",2006,10.1186/1477-7827-4-12,https://pubmed.ncbi.nlm.nih.gov/16551357/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,24284835,Differences in cytoplasmic maturation between the BCB+ and control porcine oocytes do not justify application of the BCB test for a standard IVM protocol.,2014,10.1262/jrd.2013-092,https://pubmed.ncbi.nlm.nih.gov/24284835/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,25330369,"Altered theca and cumulus oocyte complex gene expression, follicular arrest and reduced fertility in cows with dominant follicle follicular fluid androgen excess.",2014,10.1371/journal.pone.0110683,https://pubmed.ncbi.nlm.nih.gov/25330369/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1,ENSG00000182223,Neither,12539046,Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition.,2003,10.1038/ng1079,https://pubmed.ncbi.nlm.nih.gov/12539046/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1L,ENSG00000189167,Neither,40344089,The fourspine stickleback (Apeltes quadracus) has an XY sex chromosome system with polymorphic inversions on both X and Y chromosomes.,2025,10.1371/journal.pgen.1011465,https://pubmed.ncbi.nlm.nih.gov/40344089/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1L,ENSG00000189167,Neither,38786026,Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.,2024,10.3390/cells13100802,https://pubmed.ncbi.nlm.nih.gov/38786026/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1L,ENSG00000189167,Neither,40663988,"A timecourse analysis of gonadal histology and transcriptome during the sexual development of yellow catfish, Pelteobagrus fulvidraco.",2025,10.1016/j.cbd.2025.101576,https://pubmed.ncbi.nlm.nih.gov/40663988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1L,ENSG00000189167,Neither,38909509,Comparative genome-wide association study on body weight in Chinese native ducks using four models.,2024,10.1016/j.psj.2024.103899,https://pubmed.ncbi.nlm.nih.gov/38909509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1L,ENSG00000189167,Neither,35072788,Revisiting ZAR proteins: the understudied regulator of female fertility and beyond.,2022,10.1007/s00018-022-04141-4,https://pubmed.ncbi.nlm.nih.gov/35072788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZAR1L,ENSG00000189167,Neither,20014101,Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing components and its dominant-negative mutant caused two-cell-stage embryonic arrest.,2010,10.1002/dvdy.22170,https://pubmed.ncbi.nlm.nih.gov/20014101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZC3H11B,ENSG00000215817,Neither,41917377,Genetic associations of corneal astigmatism in Hong Kong Chinese children.,2026,10.1038/s41598-026-46723-3,https://pubmed.ncbi.nlm.nih.gov/41917377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZC3H11B,ENSG00000215817,Neither,40618956,Association of shared gene polymorphisms for refraction and axial length with corneal biomechanical properties in children.,2026,10.1016/j.apjo.2025.100225,https://pubmed.ncbi.nlm.nih.gov/40618956/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZC3H11B,ENSG00000215817,Neither,39762938,Whole-genome sequencing identifies novel loci for keratoconus and facilitates risk stratification in a Han Chinese population.,2025,10.1186/s40662-024-00421-1,https://pubmed.ncbi.nlm.nih.gov/39762938/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZC3H11B,ENSG00000215817,Neither,36584111,Shared genetic architecture of hernias: A genome-wide association study with multivariable meta-analysis of multiple hernia phenotypes.,2022,10.1371/journal.pone.0272261,https://pubmed.ncbi.nlm.nih.gov/36584111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZC3H11B,ENSG00000215817,Neither,37165999,Evaluation of myopia-associated genes in a Han Chinese population with high myopia.,2023,10.1080/13816810.2023.2191709,https://pubmed.ncbi.nlm.nih.gov/37165999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZC3H11B,ENSG00000215817,Neither,32816751,Genetic associations of myopia severities and endophenotypes in children.,2021,10.1136/bjophthalmol-2020-316728,https://pubmed.ncbi.nlm.nih.gov/32816751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZC3H11B,ENSG00000215817,Neither,31816047,Insights into the genetic basis of retinal detachment.,2020,10.1093/hmg/ddz294,https://pubmed.ncbi.nlm.nih.gov/31816047/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZC3H11B,ENSG00000215817,Neither,32761137,Association of WNT7B and RSPO1 with Axial Length in School Children.,2020,10.1167/iovs.61.10.11,https://pubmed.ncbi.nlm.nih.gov/32761137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZC3H11B,ENSG00000215817,Neither,37266952,Association of Polymorphisms in ZFHX1B and PAX6 With Anisometropia in Chinese Children: The Hong Kong Children Eye Genetics Study.,2023,10.1167/iovs.64.7.6,https://pubmed.ncbi.nlm.nih.gov/37266952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZC3H11B,ENSG00000215817,Neither,22685421,Genetic variants on chromosome 1q41 influence ocular axial length and high myopia.,2012,10.1371/journal.pgen.1002753,https://pubmed.ncbi.nlm.nih.gov/22685421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZC3H11B,ENSG00000215817,Neither,30306274,Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci.,2018,10.1007/s00439-018-1942-8,https://pubmed.ncbi.nlm.nih.gov/30306274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZC3H11B,ENSG00000215817,Neither,32428537,Genome-Wide Association Study in Asians Identifies Novel Loci for High Myopia and Highlights a Nervous System Role in Its Pathogenesis.,2020,10.1016/j.ophtha.2020.05.014,https://pubmed.ncbi.nlm.nih.gov/32428537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZC3H11B,ENSG00000215817,Neither,24144296,"Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.",2013,10.1016/j.ajhg.2013.06.016,https://pubmed.ncbi.nlm.nih.gov/24144296/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,42264139,HDAC2-mediated H3K27ac Governs ZFP42 transcription and autophagy in granulosa cells of pigs.,2026,10.1016/j.lfs.2026.124527,https://pubmed.ncbi.nlm.nih.gov/42264139/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,42507735,"Pilot study: The effect of eight weeks of aerobic training in the two phases of light and dark circadian rhythm on genes (OCT4, NANOG, SOX2, REX1) in bone tissue of diabetic mice.",2026,10.1371/journal.pone.0353987,https://pubmed.ncbi.nlm.nih.gov/42507735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,42030940,MECP2 mutations rewire human ESC fate and bias cortical lineage commitment.,2026,10.1016/j.stemcr.2026.102895,https://pubmed.ncbi.nlm.nih.gov/42030940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,42248461,The Rho guanine-nucleotide exchange factor P-Rex2 exhibits structural and regulatory features distinct from the related RhoGEF P-Rex1.,2026,10.1016/j.jbc.2026.113229,https://pubmed.ncbi.nlm.nih.gov/42248461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,42115169,Endocrine therapy reprogramming of breast cancer facilitates metastatic escape via upregulation of P-Rex1/Rac1 signalling.,2026,10.1038/s41467-026-70683-x,https://pubmed.ncbi.nlm.nih.gov/42115169/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,41566016,ZFP42 maintains stemness and rhythmic transcription in human epidermal stem and progenitor cells via CRY1.,2026,10.1038/s42003-026-09576-0,https://pubmed.ncbi.nlm.nih.gov/41566016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,41494241,"The rs713586 risk variant dysregulates ADCY3 rather than DNAJC27, leading to obesity through ZFP42-TET1-mediated DNA methylation.",2026,10.1016/j.ebiom.2025.106112,https://pubmed.ncbi.nlm.nih.gov/41494241/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,41100251,P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity.,2025,10.1016/j.celrep.2025.116403,https://pubmed.ncbi.nlm.nih.gov/41100251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,42069100,P-Rex Rac-GEFs.,2026,10.1016/j.cellsig.2026.112566,https://pubmed.ncbi.nlm.nih.gov/42069100/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,41098722,P-Rex1 controls phagocytosis and the killing of bacteria by murine neutrophils independently of its catalytic activity.,2025,10.3389/fimmu.2025.1591006,https://pubmed.ncbi.nlm.nih.gov/41098722/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,41269478,Anti-inflammatory and neuroprotective effect of bryodulcosigenin against cerebral ischemia/reperfusion injury via modulation of inflammatory signaling pathways.,2026,10.1007/s10787-025-02018-z,https://pubmed.ncbi.nlm.nih.gov/41269478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,39695095,CPNE7 promotes colorectal tumorigenesis by interacting with NONO to initiate ZFP42 transcription.,2024,10.1038/s41419-024-07288-z,https://pubmed.ncbi.nlm.nih.gov/39695095/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,41298451,Microprotein PLUM encoded by Lin28b uORF is a cytoplasmic determinant of pluripotency and embryonic development.,2025,10.1038/s41467-025-66297-4,https://pubmed.ncbi.nlm.nih.gov/41298451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,41892264,Molecular Basis of Sperm Methylome Response to Aging and Stress.,2026,10.3390/biology15060504,https://pubmed.ncbi.nlm.nih.gov/41892264/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,42304383,Single-cell multi-omics dissection of RevitalAge Markers uncovers age-dependent immunotherapy resistance and druggable targets in melanoma.,2026,10.1186/s13062-026-00860-x,https://pubmed.ncbi.nlm.nih.gov/42304383/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,38113263,Roles of the Rlim-Rex1 axis during X chromosome inactivation in mice.,2023,10.1073/pnas.2313200120,https://pubmed.ncbi.nlm.nih.gov/38113263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,40455837,Conserved domains and structural motifs that differentiate closely related Rex1 and Rex3 DEDDh exoribonucleases are required for their function in yeast.,2025,10.1371/journal.pone.0321120,https://pubmed.ncbi.nlm.nih.gov/40455837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,41882225,FGF4 initiates X-chromosome inactivation via activating YY1 and prompting loss of pluripotency factors.,2026,10.1038/s44318-026-00722-2,https://pubmed.ncbi.nlm.nih.gov/41882225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,38884093,"Migration, invasion, and metastasis are mediated by P-Rex1 in neuroblastoma.",2024,10.3389/fonc.2024.1336031,https://pubmed.ncbi.nlm.nih.gov/38884093/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,40034318,Unveiling distinctions between mesenchymal stromal cells and stem cells by single-cell transcriptomic analysis.,2025,10.1016/j.heliyon.2025.e42311,https://pubmed.ncbi.nlm.nih.gov/40034318/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,38098889,Structural Dynamics of P-Rex1 Complexed with Natural Leads Establishes the Protein as an Attractive Target for Therapeutics to Suppress Cancer Metastasis.,2023,10.1155/2023/3882081,https://pubmed.ncbi.nlm.nih.gov/38098889/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,38677972,Prognostic Analysis of Lactic Acid Metabolism Genes in Oral Squamous Cell Carcinoma.,2024,10.1016/j.identj.2024.04.005,https://pubmed.ncbi.nlm.nih.gov/38677972/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,40259664,The small GTPase Rap1A expedites the NOX2 oxidative burst by facilitating Rac and NOX2 autoactivations.,2025,10.1111/febs.70107,https://pubmed.ncbi.nlm.nih.gov/40259664/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,39337396,Exploring the Potential Effects of Cryopreservation on the Biological Characteristics and Cardiomyogenic Differentiation of Rat Adipose-Derived Mesenchymal Stem Cells.,2024,10.3390/ijms25189908,https://pubmed.ncbi.nlm.nih.gov/39337396/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,39107707,Neighborhood-level deprivation and survival in lung cancer.,2024,10.1186/s12885-024-12720-w,https://pubmed.ncbi.nlm.nih.gov/39107707/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,35875157,"P-Rex1 Signaling Hub in Lower Grade Glioma Patients, Found by In Silico Data Mining, Correlates With Reduced Survival and Augmented Immune Tumor Microenvironment.",2022,10.3389/fonc.2022.922025,https://pubmed.ncbi.nlm.nih.gov/35875157/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,39919125,"Novel risk loci encompassing genes influencing STAT3, GPCR, and oxidative stress signaling are associated with co-morbid GERD and COPD.",2025,10.1371/journal.pgen.1011531,https://pubmed.ncbi.nlm.nih.gov/39919125/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,38092774,Analyzing aberrant DNA methylation in colorectal cancer uncovered intangible heterogeneity of gene effects in the survival time of patients.,2023,10.1038/s41598-023-47377-1,https://pubmed.ncbi.nlm.nih.gov/38092774/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,34661084,Multiple Guanine Nucleotide Exchange Factors Mediate Glucose-Induced Rac1 Activation and Insulin Secretion: Is It Precise Regulatory Control or a Case of Two Peas from the Same Pod?,2021,10.1021/acsptsci.1c00190,https://pubmed.ncbi.nlm.nih.gov/34661084/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,37980029,Perfluorinated iodine alkanes promote the differentiation of mouse embryonic stem cells by regulating estrogen receptor signaling.,2024,10.1016/j.jes.2023.02.017,https://pubmed.ncbi.nlm.nih.gov/37980029/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,31900312,"Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1-Dependent Functions in Neutrophils.",2020,10.1124/mol.119.117556,https://pubmed.ncbi.nlm.nih.gov/31900312/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,31286410,P-Rex1 Overexpression Results in Aberrant Neuronal Polarity and Psychosis-Related Behaviors.,2019,10.1007/s12264-019-00408-2,https://pubmed.ncbi.nlm.nih.gov/31286410/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,33097662,"PtdIns(3,4,5)P&lt;sub&gt;3&lt;/sub&gt;-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis.",2020,10.1073/pnas.2006445117,https://pubmed.ncbi.nlm.nih.gov/33097662/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,16865673,"The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures.",2006,10.1002/mc.20186,https://pubmed.ncbi.nlm.nih.gov/16865673/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,16424014,"Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors.",2006,10.1158/0008-5472.can-05-2445,https://pubmed.ncbi.nlm.nih.gov/16424014/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,16344273,"Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma.",2006,10.1093/carcin/bgi299,https://pubmed.ncbi.nlm.nih.gov/16344273/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP42,ENSG00000179059,Neither,12110702,Preimplantation human embryos and embryonic stem cells show comparable expression of stage-specific embryonic antigens.,2002,10.1634/stemcells.20-4-329,https://pubmed.ncbi.nlm.nih.gov/12110702/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIM3,ENSG00000141946,Neither,38510978,"Paradoxical effects of ZIM3, a CRISPRi effector, on human induced pluripotent stem-cell-derived cardiomyocyte electrophysiology.",2024,10.1093/pnasnexus/pgae027,https://pubmed.ncbi.nlm.nih.gov/38510978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIM3,ENSG00000141946,Neither,40674211,CRISPR-based screening identifies the role of KRAB-containing transcription factors ZIM3 and ZNF394 in human major zygotic genome activation.,2025,10.1016/j.celrep.2025.116015,https://pubmed.ncbi.nlm.nih.gov/40674211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIM3,ENSG00000141946,Neither,41849608,KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival.,2026,10.1126/sciadv.aea2106,https://pubmed.ncbi.nlm.nih.gov/41849608/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIM3,ENSG00000141946,Neither,40270035,CRISPR/Cas-mediated mRNA knockdown in the embryos of Xenopus tropicalis.,2025,10.1186/s13578-025-01397-8,https://pubmed.ncbi.nlm.nih.gov/40270035/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIM3,ENSG00000141946,Neither,41005541,A next-generation platform for highly optimized CRISPR-mediated transcriptional repression.,2025,10.1016/j.jbiotec.2025.09.012,https://pubmed.ncbi.nlm.nih.gov/41005541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIM3,ENSG00000141946,Neither,36161509,ZIM3 activation of CCL25 expression in pulmonary metastatic nodules of osteosarcoma recruits M2 macrophages to promote metastatic growth.,2023,10.1007/s00262-022-03300-7,https://pubmed.ncbi.nlm.nih.gov/36161509/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIM3,ENSG00000141946,Neither,40506744,Engineering novel CRISPRi repressors for highly efficient mammalian gene regulation.,2025,10.1186/s13059-025-03640-4,https://pubmed.ncbi.nlm.nih.gov/40506744/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIM3,ENSG00000141946,Neither,38062109,CRISPRi gene modulation and all-optical electrophysiology in post-differentiated human iPSC-cardiomyocytes.,2023,10.1038/s42003-023-05627-y,https://pubmed.ncbi.nlm.nih.gov/38062109/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIM3,ENSG00000141946,Neither,36576240,Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors.,2022,10.7554/elife.81856,https://pubmed.ncbi.nlm.nih.gov/36576240/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIM3,ENSG00000141946,Neither,36951113,On the dependent recognition of some long zinc finger proteins.,2023,10.1093/nar/gkad207,https://pubmed.ncbi.nlm.nih.gov/36951113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIM3,ENSG00000141946,Neither,32793132,Production of Highly Active Extracellular Amylase and Cellulase From Bacillus subtilis ZIM3 and a Recombinant Strain With a Potential Application in Tobacco Fermentation.,2020,10.3389/fmicb.2020.01539,https://pubmed.ncbi.nlm.nih.gov/32793132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIM3,ENSG00000141946,Neither,33020655,An efficient KRAB domain for CRISPRi applications in human cells.,2020,10.1038/s41592-020-0966-x,https://pubmed.ncbi.nlm.nih.gov/33020655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIM3,ENSG00000141946,Neither,32731098,DNA methylation dynamics during zygotic genome activation in goat.,2020,10.1016/j.theriogenology.2020.07.008,https://pubmed.ncbi.nlm.nih.gov/32731098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIM3,ENSG00000141946,Neither,25317109,Regulation and function of the peg3 imprinted domain.,2014,10.5808/gi.2014.12.3.105,https://pubmed.ncbi.nlm.nih.gov/25317109/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIM3,ENSG00000141946,Neither,19397955,DNA methylation analysis of the mammalian PEG3 imprinted domain.,2009,10.1016/j.gene.2009.04.016,https://pubmed.ncbi.nlm.nih.gov/19397955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIM3,ENSG00000141946,Neither,22394678,Imprinting control region (ICR) of the Peg3 domain.,2012,10.1093/hmg/dds092,https://pubmed.ncbi.nlm.nih.gov/22394678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIM3,ENSG00000141946,Neither,11543637,"Imprinting and evolution of two Kruppel-type zinc-finger genes, ZIM3 and ZNF264, located in the PEG3/USP29 imprinted domain.",2001,10.1006/geno.2001.6621,https://pubmed.ncbi.nlm.nih.gov/11543637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIM3,ENSG00000141946,Neither,17509818,Genomic organization and imprinting of the Peg3 domain in bovine.,2007,10.1016/j.ygeno.2007.03.012,https://pubmed.ncbi.nlm.nih.gov/17509818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,42206677,ZNF469 drives TGF-β1/SMAD3-mediated extracellular matrix regulation in pulmonary fibrosis.,2026,10.17305/bb.2026.14165,https://pubmed.ncbi.nlm.nih.gov/42206677/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,42423853,Identification of ZNF469 as a potential biomarker and therapeutic target for gastric cancer through integrated multi dataset analysis.,2026,10.1007/s12672-026-05297-2,https://pubmed.ncbi.nlm.nih.gov/42423853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,40910217,ZNF469 promotes extracellular matrix production in normal and keloid dermal fibroblasts.,2025,10.3892/mmr.2025.13668,https://pubmed.ncbi.nlm.nih.gov/40910217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,40156465,On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469.,2025,10.1002/2211-5463.70034,https://pubmed.ncbi.nlm.nih.gov/40156465/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,39998893,The transcription factor ZNF469 regulates collagen production in liver fibrosis.,2025,10.1172/jci.insight.182232,https://pubmed.ncbi.nlm.nih.gov/39998893/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,42805497,Zfp469 Deletion Attenuates Liver Fibrosis by Suppressing Extracellular Matrix Production in Hepatic Stellate Cells.,2026,10.1016/j.bj.2026.101044,https://pubmed.ncbi.nlm.nih.gov/42805497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,41015554,Five novel &lt;i&gt;ZNF469&lt;/i&gt; gene mutations in sporadic keratoconus patients in the Han Chinese population.,2025,10.11817/j.issn.1672-7347.2025.240114,https://pubmed.ncbi.nlm.nih.gov/41015554/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,40911248,Identification of pathogenic variants in six Chinese families with keratoconus of autosomal dominant inheritance: pathogenicity analysis and variable phenotype.,2025,10.1007/s10792-025-03740-x,https://pubmed.ncbi.nlm.nih.gov/40911248/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,40547359,Polymorphous corneal dystrophy subtype 3 and keratoconus aggravation after corneal refractive surgery in a three-generation family carrying both &lt;i&gt;ZEB1&lt;/i&gt; and &lt;i&gt;ZNF469&lt;/i&gt; pathogenic variant.,2025,10.3389/fgene.2025.1603019,https://pubmed.ncbi.nlm.nih.gov/40547359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,39769491,A Possible Phenotype-to-Genotype Association of Novel Single-Nucleotide Variants in the Coding Exons of the ZNF469 Gene to Arterial Aneurysmal and Dissection Diseases.,2024,10.3390/ijms252413730,https://pubmed.ncbi.nlm.nih.gov/39769491/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,41595486,The Genetic and Epigenetic Architecture of Keratoconus: Emerging Pathways and Clinical Implications.,2026,10.3390/genes17010066,https://pubmed.ncbi.nlm.nih.gov/41595486/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,38961930,Brittle cornea syndrome: A novel mutation.,2024,10.1016/j.heliyon.2024.e32506,https://pubmed.ncbi.nlm.nih.gov/38961930/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,38704698,ZNF469 is a profibrotic regulator of extracellular matrix in hepatic stellate cells.,2024,10.1002/jcb.30578,https://pubmed.ncbi.nlm.nih.gov/38704698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,38439828,Variants in the ZNF469 gene in families with Brittle cornea syndrome and keratoconus.,2024,10.1016/j.heliyon.2024.e27052,https://pubmed.ncbi.nlm.nih.gov/38439828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,40510151,Leaf-vein-inspired multi-organ microfluidic chip for modeling breast cancer CTC organotropism.,2025,10.3389/fonc.2025.1602225,https://pubmed.ncbi.nlm.nih.gov/40510151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,38892036,"An Eye into the Aorta: The Role of Extracellular Matrix Regulatory Genes &lt;i&gt;ZNF469&lt;/i&gt; and &lt;i&gt;PRDM5&lt;/i&gt;, from Their Previous Association with Brittle Cornea Syndrome to Their Novel Association with Aortic and Arterial Aneurysmal Diseases.",2024,10.3390/ijms25115848,https://pubmed.ncbi.nlm.nih.gov/38892036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,41010011,Congenital Diaphragmatic Hernia and Joint Laxity: A Putative Link with Heritable Connective Tissue Disorders.,2025,10.3390/genes16091066,https://pubmed.ncbi.nlm.nih.gov/41010011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,38151328,[Mutational Signatures Analysis of Micropapillary Components and Exploration of ZNF469 Gene in Early-stage Lung Adenocarcinoma with Ground-glass Opacities].,2024,10.3779/j.issn.1009-3419.2023.106.23,https://pubmed.ncbi.nlm.nih.gov/38151328/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,37256609,Znf469 Plays a Critical Role in Regulating Synthesis of ECM: A Zebrafish Model of Brittle Cornea Syndrome.,2023,10.1167/iovs.64.5.29,https://pubmed.ncbi.nlm.nih.gov/37256609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,39238637,AXL expression reflects tumor-immune cell dynamics impacting outcome in non-small cell lung cancer patients treated with immune checkpoint inhibitor monotherapy.,2024,10.3389/fimmu.2024.1444007,https://pubmed.ncbi.nlm.nih.gov/39238637/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,40910240,Comparing Ovarian Clear Cell Carcinoma and High-Grade Serous Carcinoma Based on the SEER Database and Analyzing the Significantly Mutated Genes.,2025,10.2174/0115680096370568250806153217,https://pubmed.ncbi.nlm.nih.gov/40910240/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,38267912,Genetic variants in the FOXO1 and ZNF469 genes are associated with keratoconus in Sweden: a case-control study.,2024,10.1186/s12886-024-03299-8,https://pubmed.ncbi.nlm.nih.gov/38267912/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,39247375,Potential regulation and prognostic model of colorectal cancer with extracellular matrix genes.,2024,10.1016/j.heliyon.2024.e36164,https://pubmed.ncbi.nlm.nih.gov/39247375/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,33543230,Identification of potential biomarkers associated with immune infiltration in the esophageal carcinoma tumor microenvironment.,2021,10.1042/bsr20202439,https://pubmed.ncbi.nlm.nih.gov/33543230/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,36077702,Whole-Exome Sequencing Reveals the Genomic Features of the Micropapillary Component in Ground-Glass Opacities.,2022,10.3390/cancers14174165,https://pubmed.ncbi.nlm.nih.gov/36077702/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,35276006,Genetic Diagnostics in Routine Osteological Assessment of Adult Low Bone Mass Disorders.,2022,10.1210/clinem/dgac147,https://pubmed.ncbi.nlm.nih.gov/35276006/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,34599228,Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans.,2021,10.1038/s41598-021-98883-z,https://pubmed.ncbi.nlm.nih.gov/34599228/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,28171582,Genome-wide association study identifies WNT7B as a novel locus for central corneal thickness in Latinos.,2016,10.1093/hmg/ddw319,https://pubmed.ncbi.nlm.nih.gov/28171582/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF469,ENSG00000225614,Neither,18452888,Deleterious mutations in the Zinc-Finger 469 gene cause brittle cornea syndrome.,2008,10.1016/j.ajhg.2008.04.001,https://pubmed.ncbi.nlm.nih.gov/18452888/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF479,ENSG00000185177,Neither,34042257,Knockdown of ZNF479 inhibits proliferation and glycolysis of gastric cancer cells through regulating β-catenin/c-Myc signaling pathway.,2021,10.1002/kjm2.12399,https://pubmed.ncbi.nlm.nih.gov/34042257/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF479,ENSG00000185177,Neither,31138789,ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma.,2019,10.1038/s41419-019-1651-9,https://pubmed.ncbi.nlm.nih.gov/31138789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF479,ENSG00000185177,Neither,37028690,Gene network analyses of larvae under different egg-protecting behaviors provide novel insights into immune response mechanisms of Amphioctopus fangsiao.,2023,10.1016/j.fsi.2023.108733,https://pubmed.ncbi.nlm.nih.gov/37028690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF479,ENSG00000185177,Neither,30670742,A CATH domain functional family based approach to identify putative cancer driver genes and driver mutations.,2019,10.1038/s41598-018-36401-4,https://pubmed.ncbi.nlm.nih.gov/30670742/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF479,ENSG00000185177,Neither,11410164,"Molecular cloning and preliminary functional analysis of two novel human KRAB zinc finger proteins, HKr18 and HKr19.",2001,10.1089/104454901750232472,https://pubmed.ncbi.nlm.nih.gov/11410164/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF501,ENSG00000186446,Neither,37794117,Whole-genome sequencing analysis of suicide deaths integrating brain-regulatory eQTLs data to identify risk loci and genes.,2023,10.1038/s41380-023-02282-x,https://pubmed.ncbi.nlm.nih.gov/37794117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF501,ENSG00000186446,Neither,35688290,Zinc finger protein 501 maintains glioblastoma cell growth through enhancing Frizzled-6 expression.,2022,10.1016/j.neures.2022.06.003,https://pubmed.ncbi.nlm.nih.gov/35688290/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF501,ENSG00000186446,Neither,39238829,Identification and Validation of Hub Genes and Construction of miRNA-Gene and Transcription Factor-Gene Networks in Adipogenesis of Mesenchymal Stem Cells.,2024,10.1155/2024/5789593,https://pubmed.ncbi.nlm.nih.gov/39238829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF501,ENSG00000186446,Neither,34021117,Transcriptome-wide association study identifies new susceptibility genes and pathways for depression.,2021,10.1038/s41398-021-01411-w,https://pubmed.ncbi.nlm.nih.gov/34021117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF501,ENSG00000186446,Neither,31719968,RNA sequencing of identical twins discordant for autism reveals blood-based signatures implicating immune and transcriptional dysregulation.,2019,10.1186/s13229-019-0285-1,https://pubmed.ncbi.nlm.nih.gov/31719968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF560,ENSG00000198028,Neither,39747304,The zinc finger protein560(ZNF560) functions as a novel oncogenic gene in osteosarcoma.,2025,10.1038/s41598-024-79298-y,https://pubmed.ncbi.nlm.nih.gov/39747304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF560,ENSG00000198028,Neither,42488132,Ubiquitin-Proteasome System-Related Prognostic Model and Immune Landscape in Glioblastoma.,2026,10.1155/ijog/2045937,https://pubmed.ncbi.nlm.nih.gov/42488132/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF560,ENSG00000198028,Neither,30419062,Association of specific gene mutations derived from machine learning with survival in lung adenocarcinoma.,2018,10.1371/journal.pone.0207204,https://pubmed.ncbi.nlm.nih.gov/30419062/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF560,ENSG00000198028,Neither,35127715,Identification and Validation of a Prognostic Risk-Scoring Model Based on Ferroptosis-Associated Cluster in Acute Myeloid Leukemia.,2021,10.3389/fcell.2021.800267,https://pubmed.ncbi.nlm.nih.gov/35127715/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF560,ENSG00000198028,Neither,29912415,Primary Melanoma Histologic Subtype: Impact on Survival and Response to Therapy.,2019,10.1093/jnci/djy086,https://pubmed.ncbi.nlm.nih.gov/29912415/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF560,ENSG00000198028,Neither,24137329,Screening for differentially expressed genes between left- and right-sided colon carcinoma by microarray analysis.,2013,10.3892/ol.2013.1414,https://pubmed.ncbi.nlm.nih.gov/24137329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF679,ENSG00000197123,Neither,37093180,Copy number variation of the ZNF679 gene in cattle and its association analysis with growth traits.,2023,10.1080/10495398.2023.2185628,https://pubmed.ncbi.nlm.nih.gov/37093180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF679,ENSG00000197123,Neither,36943184,Evaluate the developmental competence of human 8-cell embryos by single-cell RNA sequencing.,2023,10.1530/raf-22-0119,https://pubmed.ncbi.nlm.nih.gov/36943184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF705A,ENSG00000196946,Neither,33517372,"A comprehensive survey for human transcription factors on expression, regulation, interaction, phenotype and cancer survival.",2021,10.1093/bib/bbab002,https://pubmed.ncbi.nlm.nih.gov/33517372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF705A,ENSG00000196946,Neither,36405735,A nomogram model based on the number of examined lymph nodes-related signature to predict prognosis and guide clinical therapy in gastric cancer.,2022,10.3389/fimmu.2022.947802,https://pubmed.ncbi.nlm.nih.gov/36405735/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF705D,ENSG00000215343,Neither,34051764,Authentication of differential gene expression in oral squamous cell carcinoma using machine learning applications.,2021,10.1186/s12903-021-01642-9,https://pubmed.ncbi.nlm.nih.gov/34051764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF716,ENSG00000182111,Neither,33517372,"A comprehensive survey for human transcription factors on expression, regulation, interaction, phenotype and cancer survival.",2021,10.1093/bib/bbab002,https://pubmed.ncbi.nlm.nih.gov/33517372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF716,ENSG00000182111,Neither,29883365,The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese.,2018,10.18632/aging.101461,https://pubmed.ncbi.nlm.nih.gov/29883365/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF716,ENSG00000182111,Neither,24376456,Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.,2013,10.3389/fgene.2013.00277,https://pubmed.ncbi.nlm.nih.gov/24376456/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF729,ENSG00000196350,Neither,41034587,A human-specific regulatory mechanism revealed in a pre-implantation model.,2025,10.1038/s41586-025-09571-1,https://pubmed.ncbi.nlm.nih.gov/41034587/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF729,ENSG00000196350,Neither,36916520,Molecular genetic characteristics of thymic epithelial tumors with distinct histological subtypes.,2023,10.1002/cam4.5795,https://pubmed.ncbi.nlm.nih.gov/36916520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF729,ENSG00000196350,Neither,32516399,Studies of human twins reveal genetic variation that affects dietary fat perception.,2020,10.1093/chemse/bjaa036,https://pubmed.ncbi.nlm.nih.gov/32516399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF730,ENSG00000183850,Neither,41934611,Transcriptional mechanisms of sex-biased gene expression and their connections to disease-associated variation.,2026,10.1093/hmg/ddag019,https://pubmed.ncbi.nlm.nih.gov/41934611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF813,ENSG00000198346,Neither,41694793,Copy Number Variant Duplications Associated with Essential Tremor.,2026,10.5334/tohm.1132,https://pubmed.ncbi.nlm.nih.gov/41694793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF813,ENSG00000198346,Neither,35285582,Identification of tumor antigens and immune subtypes of glioma for mRNA vaccine development.,2022,10.1002/cam4.4633,https://pubmed.ncbi.nlm.nih.gov/35285582/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF813,ENSG00000198346,Neither,30991224,Circulating essential metals and lung cancer: Risk assessment and potential molecular effects.,2019,10.1016/j.envint.2019.04.021,https://pubmed.ncbi.nlm.nih.gov/30991224/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF813,ENSG00000198346,Neither,26041877,Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells.,2015,10.18632/oncotarget.3939,https://pubmed.ncbi.nlm.nih.gov/26041877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF813,ENSG00000198346,Neither,33415023,"Classify multicategory outcome in patients with lung adenocarcinoma using clinical, transcriptomic and clinico-transcriptomic data: machine learning versus multinomial models.",2020,,https://pubmed.ncbi.nlm.nih.gov/33415023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,42726709,From gut to pancreas: Shared genetic susceptibility and biological convergence in acute pancreatitis and Crohn's disease.,2026,10.1371/journal.pone.0353031,https://pubmed.ncbi.nlm.nih.gov/42726709/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,41089893,Coordinated Transcriptomic and Epigenetic Approach Reveals Molecular Features Underlying Natural Mating Ability in Captive Male Giant Pandas.,2025,10.1002/ece3.72283,https://pubmed.ncbi.nlm.nih.gov/41089893/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,33507524,The Germ Cell-Specific Markers ZPBP2 and PGK2 in Testicular Biopsies Can Predict the Presence as well as the Quality of Sperm in Non-obstructive Azoospermia Patients.,2021,10.1007/s43032-020-00427-9,https://pubmed.ncbi.nlm.nih.gov/33507524/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,39277589,Sequence variants influencing the regulation of serum IgG subclass levels.,2024,10.1038/s41467-024-52470-8,https://pubmed.ncbi.nlm.nih.gov/39277589/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,35863763,Testis-specific serine protease PRSS54 regulates acrosomal granule localization and sperm head morphogenesis in mice†.,2022,10.1093/biolre/ioac146,https://pubmed.ncbi.nlm.nih.gov/35863763/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,31560728,Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock.,2019,10.1371/journal.pone.0223212,https://pubmed.ncbi.nlm.nih.gov/31560728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,29709669,Does reduced zona pellucida binding protein 2 (ZPBP2) expression on chromosome 17q21 protect against asthma?,2018,10.1016/j.jaci.2018.04.011,https://pubmed.ncbi.nlm.nih.gov/29709669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,36967681,Association of Asthma Risk Alleles With Acute Respiratory Tract Infections and Wheezing Illnesses in Young Children.,2023,10.1093/infdis/jiad075,https://pubmed.ncbi.nlm.nih.gov/36967681/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,32273303,Treatment of Allergic Asthma with Fenretinide Formulation (LAU-7b) Downregulates ORMDL Sphingolipid Biosynthesis Regulator 3 (&lt;i&gt;Ormdl3&lt;/i&gt;) Expression and Normalizes Ceramide Imbalance.,2020,10.1124/jpet.119.263715,https://pubmed.ncbi.nlm.nih.gov/32273303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,28241063,Role of DNA methylation in expression control of the IKZF3-GSDMA region in human epithelial cells.,2017,10.1371/journal.pone.0172707,https://pubmed.ncbi.nlm.nih.gov/28241063/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,29463315,X chromosome dosage and presence of SRY shape sex-specific differences in DNA methylation at an autosomal region in human cells.,2018,10.1186/s13293-018-0169-7,https://pubmed.ncbi.nlm.nih.gov/29463315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,29536159,Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion.,2018,10.1007/s00335-018-9743-x,https://pubmed.ncbi.nlm.nih.gov/29536159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,26771610,Optimizing a Male Reproductive Aging Mouse Model by D-Galactose Injection.,2016,10.3390/ijms17010098,https://pubmed.ncbi.nlm.nih.gov/26771610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,33179336,Genome-wide search for genes affecting the age at diagnosis of type 1 diabetes.,2021,10.1111/joim.13187,https://pubmed.ncbi.nlm.nih.gov/33179336/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,29126140,Zona pellucida-binding protein 2 (ZPBP2) and several proteins containing BX7B motifs in human sperm may have hyaluronic acid binding or recognition properties.,2017,10.1093/molehr/gax053,https://pubmed.ncbi.nlm.nih.gov/29126140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,34919286,17q12-21 risk-variants influence cord blood immune regulation and multitrigger-wheeze.,2022,10.1111/pai.13721,https://pubmed.ncbi.nlm.nih.gov/34919286/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,26671913,"Local genotype influences DNA methylation at two asthma-associated regions, 5q31 and 17q21, in a founder effect population.",2016,10.1136/jmedgenet-2015-103313,https://pubmed.ncbi.nlm.nih.gov/26671913/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,22271045,Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines.,2012,10.1007/s00439-012-1142-x,https://pubmed.ncbi.nlm.nih.gov/22271045/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,33083119,Immune cell landscape analysis reveals prognostic immune cells and its potential mechanism in squamous cell lung carcinoma.,2020,10.7717/peerj.9996,https://pubmed.ncbi.nlm.nih.gov/33083119/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,20846800,Molecular cloning of pig ZPBP2 and mRNA expression of ZPBP1 and ZPBP2 in reproductive tracts of boars.,2010,10.1016/j.anireprosci.2010.08.016,https://pubmed.ncbi.nlm.nih.gov/20846800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,29348612,GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21.,2018,10.1038/s41467-017-02596-9,https://pubmed.ncbi.nlm.nih.gov/29348612/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,27835674,Lymphocyte Activation Dynamics Is Shaped by Hereditary Components at Chromosome Region 17q12-q21.,2016,10.1371/journal.pone.0166414,https://pubmed.ncbi.nlm.nih.gov/27835674/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,27848966,17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells.,2016,10.1038/ncomms13426,https://pubmed.ncbi.nlm.nih.gov/27848966/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,28427360,Association of novel polymorphisms in TMEM39A gene with systemic lupus erythematosus in a Chinese Han population.,2017,10.1186/s12881-017-0405-8,https://pubmed.ncbi.nlm.nih.gov/28427360/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,28588209,Identification of the functional variant driving ORMDL3 and GSDMB expression in human chromosome 17q12-21 in primary biliary cholangitis.,2017,10.1038/s41598-017-03067-3,https://pubmed.ncbi.nlm.nih.gov/28588209/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,26484354,"Gene Expression-Genotype Analysis Implicates GSDMA, GSDMB, and LRRC3C as Contributors to Inflammatory Bowel Disease Susceptibility.",2015,10.1155/2015/834805,https://pubmed.ncbi.nlm.nih.gov/26484354/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,19732864,Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.,2009,10.1016/j.ajhg.2009.08.007,https://pubmed.ncbi.nlm.nih.gov/19732864/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,21546069,Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion.,2011,10.1016/j.jaci.2011.03.015,https://pubmed.ncbi.nlm.nih.gov/21546069/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP2,ENSG00000186075,Neither,17664285,Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis.,2007,10.1128/mcb.01029-07,https://pubmed.ncbi.nlm.nih.gov/17664285/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42286740,Hierarchical Disruption of the Tryptophan-Melatonin Axis Contributes to Glioma Progression Through AKT/ERK/STAT3 Signalling.,2026,10.1111/jcmm.71243,https://pubmed.ncbi.nlm.nih.gov/42286740/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42509839,Expression of Rate-Limiting Enzymes of Melatonin Synthesis in Several Extrapineal Organs During Pregnancy in Ewes.,2026,10.3390/biom16071047,https://pubmed.ncbi.nlm.nih.gov/42509839/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,41522363,Disrupted astrocyte-neuron glutamine-glutamate cycling in the medial prefrontal cortex contributes to depression-like behaviors.,2026,10.7150/ijbs.123740,https://pubmed.ncbi.nlm.nih.gov/41522363/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42516754,Placental expression and activity of system A and system L amino acid transporters in pregnancies complicated by diabetes mellitus and fetal growth disorders: a systematic review.,2026,10.3389/fendo.2026.1883051,https://pubmed.ncbi.nlm.nih.gov/42516754/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42780445,The serotonin receptor Am&lt;i&gt;5HTR2a&lt;/i&gt; links neuromodulation to MRJP1 expression and temporal polyethism in honey bees.,2026,10.3389/fphys.2026.1926478,https://pubmed.ncbi.nlm.nih.gov/42780445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,41789583,The Sex- and Age-Specific Association of AANAT Gene Polymorphisms With the Risk of Major Depressive Disorder in the Chinese Population.,2026,10.1002/jdn.70101,https://pubmed.ncbi.nlm.nih.gov/41789583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,41629966,Sex-specific gonadal transcriptome during early development of Siberian sturgeon.,2026,10.1186/s13293-025-00810-8,https://pubmed.ncbi.nlm.nih.gov/41629966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42762694,Melatonin testicular synthesis and its role in reproductive physiology in seasonal and non-seasonal breeders.,2026,10.1016/j.rvsc.2026.106397,https://pubmed.ncbi.nlm.nih.gov/42762694/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42144849,Gene misexpression system for functional studies of genes involved in cuticle development in the cricket Gryllus bimaculatus.,2026,10.1111/imb.70044,https://pubmed.ncbi.nlm.nih.gov/42144849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42801605,Smartphone-Guided Visible Light Modulation of RSNOs for Antimicrobial Activity via Controlled Nitric Oxide Release.,2026,10.1002/advs.77846,https://pubmed.ncbi.nlm.nih.gov/42801605/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,40463803,"Targeted disruption of the aralkylamine &lt;i&gt;N&lt;/i&gt;-acetyltransferase gene in a seasonal mammal, &lt;i&gt;Mesocricetus auratus&lt;/i&gt;.",2025,10.1093/pnasnexus/pgaf159,https://pubmed.ncbi.nlm.nih.gov/40463803/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42650206,Overexpression of Serotonin &lt;i&gt;N&lt;/i&gt;-Acetyltransferase Cloned from the Green Algae &lt;i&gt;Chara braunii&lt;/i&gt; Confers Peroxidizing Herbicide Tolerance Through the Induction of &lt;i&gt;Protoporphyrinogen Oxidase 1&lt;/i&gt; in Rice.,2026,10.3390/antiox15080942,https://pubmed.ncbi.nlm.nih.gov/42650206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,41366569,Hippocampal synaptic plasticity impairment and melatonin synthesis reduction in cognitive decline of a rodent model of Alzheimer's disease-like pathology.,2025,10.1007/s00424-025-03134-z,https://pubmed.ncbi.nlm.nih.gov/41366569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,41846606,Genome wide identification of serotonin N-acetyltransferase (&lt;i&gt;PbSNAT&lt;/i&gt;) gene family and their role in pear (&lt;i&gt;Pyrus bretschneideri)&lt;/i&gt; fruit development.,2026,10.3389/fpls.2026.1767313,https://pubmed.ncbi.nlm.nih.gov/41846606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,41504861,Children with Autism Spectrum Disorder and Chronic Gastrointestinal Symptoms Have Alterations in Intestinal Neurotransmitter Pathways.,2026,10.1007/s10620-026-09667-2,https://pubmed.ncbi.nlm.nih.gov/41504861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42533576,Molecular mechanisms of the hypothalamus miR-27a/ &lt;i&gt;PRKCA&lt;/i&gt; pathway in regulating neuronal function and aggression-related behavior.,2026,10.24272/j.issn.2095-8137.2025.288,https://pubmed.ncbi.nlm.nih.gov/42533576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42557933,Promoter-Level Regulation of Melatonin Biosynthesis in Plant Stress Responses: A Framework for Climate-Resilient Crop Improvement.,2026,10.1111/jpi.70158,https://pubmed.ncbi.nlm.nih.gov/42557933/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42623702,Bidirectional association of MT with H&lt;sub&gt;2&lt;/sub&gt;S improves maize heat resilience through modulation of ROS and methylglyoxal detoxification pathways.,2026,10.1016/j.plaphy.2026.111669,https://pubmed.ncbi.nlm.nih.gov/42623702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42673795,Selenium nanoparticles alleviate chromium toxicity in maize via melatonin-mediated regulation of cell wall polysaccharide metabolism and redox homeostasis.,2026,10.1016/j.jhazmat.2026.143398,https://pubmed.ncbi.nlm.nih.gov/42673795/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,41176235,Hydantion indolinones as AANAT inhibitors.,2026,10.1016/j.bmcl.2025.130459,https://pubmed.ncbi.nlm.nih.gov/41176235/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42422169,Red-teaming as an imperative for strengthening synthetic nucleic acid screening.,2026,10.3389/fbioe.2026.1841668,https://pubmed.ncbi.nlm.nih.gov/42422169/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,41647439,"Novel stable ""sandwich"" cyclodextrin inclusion of a lipophilic S-nitrosothiol for controlled delivery of nitric oxide.",2026,10.1016/j.matdes.2025.115274,https://pubmed.ncbi.nlm.nih.gov/41647439/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42747623,Amino acid transporters in hepatocellular carcinoma: Gatekeepers of metabolic reprogramming.,2026,10.1007/s11033-026-12759-x,https://pubmed.ncbi.nlm.nih.gov/42747623/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42269569,Telomerase-related gene EHHADH drives lung cancer progression and shapes the immunosuppressive tumor microenvironment.,2026,10.1016/j.tranon.2026.102852,https://pubmed.ncbi.nlm.nih.gov/42269569/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42257163,Melatonin and sleep: Exploring its role in regulating the circadian rhythm and sleep-wake cycle.,2026,10.4103/jfmpc.jfmpc_150_25,https://pubmed.ncbi.nlm.nih.gov/42257163/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42607820,Monochromatic green light programs the chicken embryo intestinal microbiota and mucosal barrier via the melatonin-Nrf2-nitrate-tryptophan pathway.,2026,10.1016/j.freeradbiomed.2026.08.035,https://pubmed.ncbi.nlm.nih.gov/42607820/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,39058147,Evaluating Molecular Mechanism of Viral Inhibition of Aerosolized Smart Nano-Enabled Antiviral Therapeutic (SNAT) on SARS-CoV-2-Infected Hamsters.,2024,10.3390/toxics12070495,https://pubmed.ncbi.nlm.nih.gov/39058147/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42794015,&lt;i&gt;Bifidobacterium longum&lt;/i&gt; B18 Modulates Pharmacologically Induced Sleep Parameters in Rats in Association with Altered Tryptophan-Melatonin Metabolism.,2026,10.3390/foods15183230,https://pubmed.ncbi.nlm.nih.gov/42794015/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,40395793,Quassinoids from Malaysian &lt;i&gt;Eurycoma longifolia&lt;/i&gt; significantly increased the expression of the melatonin biosynthesis-related enzyme gene (AANAT).,2025,10.1039/d5ra01703c,https://pubmed.ncbi.nlm.nih.gov/40395793/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,42774326,Cloning of a novel cyanobacterial serotonin N-acetyltransferase gene CySNAT3 and its integration with transcriptomic drug repurposing in pediatric obstructive sleep-disordered breathing.,2026,10.3389/fphar.2026.1851793,https://pubmed.ncbi.nlm.nih.gov/42774326/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,41878252,Support needs assessment tool for people with disability wanting to participate in sport and exercise (SNAT-SE): Usability and acceptability testing.,2025,10.1016/j.jsampl.2025.100111,https://pubmed.ncbi.nlm.nih.gov/41878252/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,37980768,Integrating social care into gynecologic oncology: Identifying and addressing patient's social needs.,2023,10.1016/j.ygyno.2023.11.001,https://pubmed.ncbi.nlm.nih.gov/37980768/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,41524434,Transcriptomic analysis of pigeon retina and pineal gland illuminated with red light.,2026,10.1080/00071668.2025.2605496,https://pubmed.ncbi.nlm.nih.gov/41524434/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,39037705,Antithrombotic and Antimicrobial Potential of S -Nitroso-1-Adamantanethiol-Impregnated Extracorporeal Circuit.,2025,10.1097/mat.0000000000002276,https://pubmed.ncbi.nlm.nih.gov/39037705/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,18212399,Role of melatonin in upper gastrointestinal tract.,2007,,https://pubmed.ncbi.nlm.nih.gov/18212399/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AANAT,ENSG00000129673,Unsafe,8661026,"The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression.",1996,10.1006/geno.1996.0243,https://pubmed.ncbi.nlm.nih.gov/8661026/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,42812431,From disease to syndrome pattern: a study on the differentiation of traditional Chinese medicine syndrome patterns in asthma using multi-omics characterization.,2026,10.3389/fimmu.2026.1922660,https://pubmed.ncbi.nlm.nih.gov/42812431/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,39861164,Revisiting ABC Transporters and Their Clinical Significance in Glioblastoma.,2025,10.3390/ph18010102,https://pubmed.ncbi.nlm.nih.gov/39861164/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,42733719,Integrating machine learning and GWAS for variant prioritization in the INCIPE cohort highlights ABC transporter genes in chronic kidney disease.,2026,10.3389/fgene.2026.1902866,https://pubmed.ncbi.nlm.nih.gov/42733719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,41975515,Proteogenomic decoding of chemotherapy resistance in patients with triple-negative breast cancer.,2026,10.1186/s13059-026-04053-7,https://pubmed.ncbi.nlm.nih.gov/41975515/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,42434344,The miR-16-1-3p passenger strand exhibits functional activity and suppresses malignant phenotypes in osteosarcoma.,2026,10.3389/fgene.2026.1837827,https://pubmed.ncbi.nlm.nih.gov/42434344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,40923997,Burn Injury Triggers Distinct Transcriptomic Profiles in Adipose Tissue of Adult and Aged Mice.,2025,10.1096/fj.202501420r,https://pubmed.ncbi.nlm.nih.gov/40923997/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,38357255,Association of ABCA13 Gene Variants with Autism Spectrum Disorder and Other Neuropsychiatric Disorders.,2024,10.1159/000534123,https://pubmed.ncbi.nlm.nih.gov/38357255/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,40069786,"Lipidomics and genomics in mental health: insights into major depressive disorder, bipolar disorder, schizophrenia, and obsessive-compulsive disorder.",2025,10.1186/s12944-025-02512-x,https://pubmed.ncbi.nlm.nih.gov/40069786/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,33299069,ATP-binding cassette transporter 13 mRNA expression level in schizophrenia patients.,2020,10.1038/s41598-020-78530-9,https://pubmed.ncbi.nlm.nih.gov/33299069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,33478937,ABCA13 dysfunction associated with psychiatric disorders causes impaired cholesterol trafficking.,2021,10.1074/jbc.ra120.015997,https://pubmed.ncbi.nlm.nih.gov/33478937/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,39135185,Multi-omics landscapes reveal heterogeneity in long COVID patients characterized with enhanced neutrophil activity.,2024,10.1186/s12967-024-05560-6,https://pubmed.ncbi.nlm.nih.gov/39135185/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,37626618,Puzzling Out the Genetic Architecture of Endometriosis: Whole-Exome Sequencing and Novel Candidate Gene Identification in a Deeply Clinically Characterised Cohort.,2023,10.3390/biomedicines11082122,https://pubmed.ncbi.nlm.nih.gov/37626618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,35359676,Use of ATP-Binding Cassette Subfamily A Member 13 (ABCA13) for Sensitive Detection of Focal Pathological Forms of Subclinical Bovine Paratuberculosis.,2022,10.3389/fvets.2022.816135,https://pubmed.ncbi.nlm.nih.gov/35359676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,34818212,Hyperbaric oxygen therapy induces transcriptome changes in elderly: a prospective trial.,2021,10.18632/aging.203709,https://pubmed.ncbi.nlm.nih.gov/34818212/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,36385764,ATP-binding cassette transporter expression is widely dysregulated in frontotemporal dementia with TDP-43 inclusions.,2022,10.3389/fnmol.2022.1043127,https://pubmed.ncbi.nlm.nih.gov/36385764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,42253507,Novel African American Colorectal Cancer &lt;i&gt;MSH3&lt;/i&gt; Variants Associate With Major Genomic Instability.,2026,10.1155/humu/5588764,https://pubmed.ncbi.nlm.nih.gov/42253507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,37323201,Clinical and Genetic Characteristics of Patients with Unexplained Intellectual Disability/Developmental Delay without Epilepsy.,2023,10.1159/000529018,https://pubmed.ncbi.nlm.nih.gov/37323201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,37017121,CircABCA13 acts as a miR-4429 sponge to facilitate esophageal squamous cell carcinoma development by stabilizing SRXN1.,2023,10.1111/cas.15807,https://pubmed.ncbi.nlm.nih.gov/37017121/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,35811316,Exome sequencing analysis of Japanese autism spectrum disorder case-control sample supports an increased burden of synaptic function-related genes.,2022,10.1038/s41398-022-02033-6,https://pubmed.ncbi.nlm.nih.gov/35811316/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,39471669,Transcriptome analyses of shell color and egg production traits between the uteruses of blue-green eggshell chickens and Hy-Line brown layers.,2024,10.1016/j.psj.2024.104438,https://pubmed.ncbi.nlm.nih.gov/39471669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,38248311,Analysis of Somatic Mutations in the TCGA-LIHC Whole Exome Sequence to Identify the Neoantigen for Immunotherapy in Hepatocellular Carcinoma.,2023,10.3390/cimb46010009,https://pubmed.ncbi.nlm.nih.gov/38248311/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,37584493,Designing of neoepitopes based vaccine against breast cancer using integrated immuno and bioinformatics approach.,2024,10.1080/07391102.2023.2247081,https://pubmed.ncbi.nlm.nih.gov/37584493/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,39036450,The unique genomic landscape and prognostic mutational signature of Chinese clear cell renal cell carcinoma.,2022,10.1016/j.jncc.2022.07.001,https://pubmed.ncbi.nlm.nih.gov/39036450/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,36896338,WGCNA-based identification of potential targets and pathways in response to treatment in locally advanced breast cancer patients.,2023,10.1515/med-2023-0651,https://pubmed.ncbi.nlm.nih.gov/36896338/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,39030589,Targeted panel sequencing of pharmacogenes and oncodrivers in colorectal cancer patients reveals genes with prognostic significance.,2024,10.1186/s40246-024-00644-2,https://pubmed.ncbi.nlm.nih.gov/39030589/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,34728653,Molecular characterization of metabolic subtypes of gastric cancer based on metabolism-related lncRNA.,2021,10.1038/s41598-021-00410-7,https://pubmed.ncbi.nlm.nih.gov/34728653/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,37359923,Multi-omics Analysis Classifies Colorectal Cancer into Distinct Methylated Immunogenic and Angiogenic Subtypes Based on Anatomical Laterality.,2023,10.1007/s13193-023-01760-6,https://pubmed.ncbi.nlm.nih.gov/37359923/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,38008721,Prognostic potential of whole exome sequencing in the clinical management of metachronous colorectal cancer liver metastases.,2023,10.1186/s12935-023-03135-x,https://pubmed.ncbi.nlm.nih.gov/38008721/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,32881863,Detection of latent forms of Mycobacterium avium subsp. paratuberculosis infection using host biomarker-based ELISAs greatly improves paratuberculosis diagnostic sensitivity.,2020,10.1371/journal.pone.0236336,https://pubmed.ncbi.nlm.nih.gov/32881863/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,36977260,The Immunoprotection of OmpH Gene Deletion Mutation of Pasteurella multocida on Hemorrhagic Sepsis in Qinghai Yak.,2023,10.3390/vetsci10030221,https://pubmed.ncbi.nlm.nih.gov/36977260/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,27699085,Proteomic Analysis of the Peri-Infarct Area after Human Umbilical Cord Mesenchymal Stem Cell Transplantation in Experimental Stroke.,2016,10.14336/ad.2016.0121,https://pubmed.ncbi.nlm.nih.gov/27699085/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,27679817,Single-neuron and genetic correlates of autistic behavior in macaque.,2016,10.1126/sciadv.1600558,https://pubmed.ncbi.nlm.nih.gov/27679817/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,31980012,Osteogenesis imperfecta in a male holstein calf associated with a possible oligogenic origin.,2020,10.1080/01652176.2020.1721611,https://pubmed.ncbi.nlm.nih.gov/31980012/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,27827358,Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation.,2016,10.1038/ncomms13294,https://pubmed.ncbi.nlm.nih.gov/27827358/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,23266639,"Evidence for an alternative genomic structure, mRNA and protein sequence of human ABCA13.",2013,10.1016/j.gene.2012.11.072,https://pubmed.ncbi.nlm.nih.gov/23266639/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA13,ENSG00000179869,Unsafe,12697998,"The human ATP binding cassette gene ABCA13, located on chromosome 7p12.3, encodes a 5058 amino acid protein with an extracellular domain encoded in part by a 4.8-kb conserved exon.",2002,10.1159/000069852,https://pubmed.ncbi.nlm.nih.gov/12697998/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,42581602,Loss of ABCA4 from photoreceptor discs is associated with glial transcriptomic changes in retinal organoids.,2026,10.1093/stmcls/sxag045,https://pubmed.ncbi.nlm.nih.gov/42581602/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,41536809,Using RNA-targeting CRISPR-Cas13 and engineered U1 systems to target &lt;i&gt;ABCA4&lt;/i&gt; splice variants in Stargardt disease.,2026,10.1016/j.omtn.2025.102789,https://pubmed.ncbi.nlm.nih.gov/41536809/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,42266249,Combination drug therapy reduces iron accumulation and microglia-mediated pathologies in neonatal intraventricular hemorrhage: a biochemical and transcriptomic analysis.,2026,10.3389/fncel.2026.1812529,https://pubmed.ncbi.nlm.nih.gov/42266249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,42153784,Abca4 Knockdown in the Cone-Rich Rodent Psammomys Obesus Leads to Stargardt's Disease-Like Progressive Retinal Degeneration.,2026,10.1167/iovs.67.5.47,https://pubmed.ncbi.nlm.nih.gov/42153784/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,42414676,Retina-specific long non-coding RNAs associated with inherited retinal disease genes.,2026,10.1007/s00018-026-06259-1,https://pubmed.ncbi.nlm.nih.gov/42414676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,42519008,DGAT1-associated lipid-retinoid dysregulation correlates with metabolic impairment in the RPE of Stargardt disease.,2026,10.1016/j.isci.2026.116727,https://pubmed.ncbi.nlm.nih.gov/42519008/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,42850292,[Genetic therapies for Stargardt disease].,2026,10.1007/s00347-026-02535-4,https://pubmed.ncbi.nlm.nih.gov/42850292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,42510768,Genotypic and Phenotypic Insights on 11 Novel Variants in the &lt;i&gt;ABCA4&lt;/i&gt; Gene.,2026,10.3390/genes17070728,https://pubmed.ncbi.nlm.nih.gov/42510768/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,42240816,Update on the Management of ABCA4 Retinopathy (Stargardt Disease).,2026,10.1007/s40123-026-01407-z,https://pubmed.ncbi.nlm.nih.gov/42240816/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,41979252,ABCA4 Versus PRPH2-Associated Retinopathy: Clinical and Electrophysiological Findings.,2026,10.1167/iovs.67.4.29,https://pubmed.ncbi.nlm.nih.gov/41979252/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,41984830,Uncovering mitochondrial defects in photoreceptors opens therapeutic opportunities for Stargardt disease.,2026,10.1073/pnas.2504764123,https://pubmed.ncbi.nlm.nih.gov/41984830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,41226778,Dysregulated DNA Methylation in &lt;i&gt;Abca4&lt;sup&gt;-/-&lt;/sup&gt;&lt;/i&gt; Retinal Pigment Epithelium: Insights into Early Stage of Stargardt Disease.,2025,10.3390/ijms262110742,https://pubmed.ncbi.nlm.nih.gov/41226778/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,42321202,Interdependent roles of PKM2 in photoreceptors and RPE: implications for retinal degeneration.,2026,10.1038/s41419-026-08997-3,https://pubmed.ncbi.nlm.nih.gov/42321202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,41533864,Characterization of the Subclinical Perilesional Zone in the Macula of Early-Stage ABCA4 Disease.,2025,10.1167/tvst.14.12.23,https://pubmed.ncbi.nlm.nih.gov/41533864/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,40693713,Investigation of ABCA4 Missense Variants and Potential Small Molecule Rescue in Retinal Organoids.,2025,10.1167/iovs.66.9.58,https://pubmed.ncbi.nlm.nih.gov/40693713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,42326091,Stargardt Disease Presenting as Retinitis Pigmentosa: A Case of Monoallelic ABCA4-Associated Retinopathy.,2026,10.7759/cureus.109345,https://pubmed.ncbi.nlm.nih.gov/42326091/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,42650171,Dissecting Missing Heritability in Rare Inherited Macular Dystrophies.,2026,10.3390/genes17080979,https://pubmed.ncbi.nlm.nih.gov/42650171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,42228027,Transcriptomic analysis of mouse testes with disordered spermatogenesis induced by high-dose BPA exposure during puberty.,2026,10.1007/s11033-026-12061-w,https://pubmed.ncbi.nlm.nih.gov/42228027/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,41038369,ABCA4-mutant human retinal organoids sequencing reveals organoids application in inherited retinal diseases.,2025,10.1016/j.exer.2025.110677,https://pubmed.ncbi.nlm.nih.gov/41038369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,41654128,More insights from Abca4&lt;sup&gt;-/-&lt;/sup&gt; mouse models of recessive Stargardt disease.,2026,10.1016/j.jbc.2026.111261,https://pubmed.ncbi.nlm.nih.gov/41654128/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,40725253,Stargardt's Disease: Molecular Pathogenesis and Current Therapeutic Landscape.,2025,10.3390/ijms26147006,https://pubmed.ncbi.nlm.nih.gov/40725253/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,41561667,&lt;i&gt;ABCA4&lt;/i&gt;-associated retinopathy complicated by didanosine-associated retinal toxicity.,2026,10.1016/j.ajoc.2025.102509,https://pubmed.ncbi.nlm.nih.gov/41561667/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,42690655,Safety and Effects of Gildeuretinol Acetate on Retinal Atrophic Lesions in Stargardt Disease: The TEASE-1 Randomized Clinical Trial.,2026,10.1001/jamaophthalmol.2026.3662,https://pubmed.ncbi.nlm.nih.gov/42690655/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,42484594,Lens Opacity in ABCA4-Associated Stargardt Disease Patients in the ProgStar Study.,2026,10.1167/iovs.67.8.47,https://pubmed.ncbi.nlm.nih.gov/42484594/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,41495677,ABCA4-associated maculopathy suspected to be ocular toxoplasmosis.,2026,10.1186/s12886-025-04594-8,https://pubmed.ncbi.nlm.nih.gov/41495677/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,41677386,Genetic Correlates of Phenotypic Variability in c.5882G&gt;A p.(Gly1961Glu)-Associated Stargardt Disease.,2026,10.1167/iovs.67.2.32,https://pubmed.ncbi.nlm.nih.gov/41677386/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,41407712,AAV-delivered engineered suppressor tRNA rescues visual function in mice with an inherited retinal disease.,2025,10.1038/s41467-025-66176-y,https://pubmed.ncbi.nlm.nih.gov/41407712/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,40233365,iCogCA to Promote Cognitive Health Through Digital Group Interventions for Individuals Living With a Schizophrenia Spectrum Disorder: Protocol for a Nonrandomized Concurrent Controlled Trial.,2025,10.2196/63269,https://pubmed.ncbi.nlm.nih.gov/40233365/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,41827889,Precise CRISPR/Cas9 and Cas12 Correction Using Lipoplexes in Retinal Models Derived from Patients with Inherited Retinal Dystrophies.,2026,10.3390/cells15050457,https://pubmed.ncbi.nlm.nih.gov/41827889/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,40273359,Generation of a compound heterozygous ABCA4 rat model with pathological features of STGD1.,2025,10.1093/hmg/ddaf057,https://pubmed.ncbi.nlm.nih.gov/40273359/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABCA4,ENSG00000198691,Unsafe,42226100,Exendin-4 averts all-trans-retinal-driven damage to photoreceptors and the retina via the GLP-1R/PKA/CREB1 signaling axis.,2026,10.1186/s11658-026-00952-6,https://pubmed.ncbi.nlm.nih.gov/42226100/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABHD1,ENSG00000143994,Unsafe,39619568,ABHD1 Facilitates Intermediate Filament-Mediated Endothelial Cell Chemotaxis by Regulating KRT1 and KRT2 in Diabetic Retinopathy.,2024,10.1155/jdr/5513165,https://pubmed.ncbi.nlm.nih.gov/39619568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABHD1,ENSG00000143994,Unsafe,41619802,Transcriptional responses to proteotoxic stressors are profoundly diverse and tissue-specific.,2026,10.1016/j.cstres.2026.100146,https://pubmed.ncbi.nlm.nih.gov/41619802/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABHD1,ENSG00000143994,Unsafe,39755455,A novel mechanism promoting lipid droplet formation.,2025,10.1016/j.tplants.2024.12.010,https://pubmed.ncbi.nlm.nih.gov/39755455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABHD1,ENSG00000143994,Unsafe,39791125,α/β hydrolase domain-containing protein 1 acts as a lysolipid lipase and is involved in lipid droplet formation.,2024,10.1093/nsr/nwae398,https://pubmed.ncbi.nlm.nih.gov/39791125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABHD1,ENSG00000143994,Unsafe,34545688,Association between ABHD1 and DOK6 polymorphisms and susceptibility to Hirschsprung disease in Southern Chinese children.,2021,10.1111/jcmm.16905,https://pubmed.ncbi.nlm.nih.gov/34545688/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABHD1,ENSG00000143994,Unsafe,12735795,The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12.,2003,10.1186/1471-2164-4-18,https://pubmed.ncbi.nlm.nih.gov/12735795/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABHD1,ENSG00000143994,Unsafe,19073140,Alpha/beta hydrolase 1 is upregulated in D5 dopamine receptor knockout mice and reduces O2- production of NADPH oxidase.,2009,10.1016/j.bbrc.2008.12.008,https://pubmed.ncbi.nlm.nih.gov/19073140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABHD1,ENSG00000143994,Unsafe,11922611,Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs.,2002,10.1006/bbrc.2002.6692,https://pubmed.ncbi.nlm.nih.gov/11922611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,42812823,ABRAXAS1-HELQ is a candidate class-matched reference chimeric RNA and contributes to prostate cell motility through MCOLN2.,2026,10.3389/fonc.2026.1935441,https://pubmed.ncbi.nlm.nih.gov/42812823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,40966517,Profiling BRCA1-BRCT interactions and their functional relevance at amino acid resolution.,2025,10.1093/nar/gkaf848,https://pubmed.ncbi.nlm.nih.gov/40966517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,41088366,Exome sequencing reveals new insights into the germline landscape of inflammatory breast cancer among Tunisian patients.,2025,10.1186/s12967-025-07027-8,https://pubmed.ncbi.nlm.nih.gov/41088366/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,37198153,ABRAXAS1 orchestrates BRCA1 activities to counter genome destabilizing repair pathways-lessons from breast cancer patients.,2023,10.1038/s41419-023-05845-6,https://pubmed.ncbi.nlm.nih.gov/37198153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,36551595,Proteome-Wide Identification of RNA-Dependent Proteins in Lung Cancer Cells.,2022,10.3390/cancers14246109,https://pubmed.ncbi.nlm.nih.gov/36551595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,39194334,Atypical cancer risk profile in carriers of Italian founder BRCA1 variant p.His1673del: Implications for classification and clinical management.,2024,10.1002/cam4.70114,https://pubmed.ncbi.nlm.nih.gov/39194334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,39683594,"Bioactivated Glucoraphanin Improves Cell Survival, Upregulating Phospho-AKT, and Modulates Genes Involved in DNA Repair in an In Vitro Alzheimer's Disease Model: A Network-Transcriptomic Analysis.",2024,10.3390/nu16234202,https://pubmed.ncbi.nlm.nih.gov/39683594/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,36568976,Integrated genomic analysis identifies novel low-frequency cis-regulatory variant rs2279658 associated with VSD risk in Chinese children.,2022,10.3389/fcell.2022.1062403,https://pubmed.ncbi.nlm.nih.gov/36568976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,37086071,Uncover DNA damage and repair-related gene signature and risk score model for glioma.,2023,10.1080/07853890.2023.2200033,https://pubmed.ncbi.nlm.nih.gov/37086071/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,38817903,Mutation characteristics of cancer susceptibility genes in Chinese ovarian cancer patients.,2024,10.3389/fonc.2024.1395818,https://pubmed.ncbi.nlm.nih.gov/38817903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,34604063,Construction and Validation of a Platinum Sensitivity Predictive Model With Multiple Genomic Variations for Epithelial Ovarian Cancer.,2021,10.3389/fonc.2021.725264,https://pubmed.ncbi.nlm.nih.gov/34604063/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,38278448,Histologic patterns in prostatic adenocarcinoma are not predictive of mutations in the homologous recombination repair pathway.,2024,10.1016/j.humpath.2024.01.005,https://pubmed.ncbi.nlm.nih.gov/38278448/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,27792995,Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.,2016,10.18632/oncotarget.12818,https://pubmed.ncbi.nlm.nih.gov/27792995/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,34261476,Somatic mutations in benign breast disease tissues and association with breast cancer risk.,2021,10.1186/s12920-021-01032-8,https://pubmed.ncbi.nlm.nih.gov/34261476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,31361614,Kaposi Sarcoma in Association With an Extracavitary Primary Effusion Lymphoma Showing Unusual Intravascular Involvement: Report of a Case Harboring a FAM175A Germline Mutation.,2020,10.1097/dad.0000000000001491,https://pubmed.ncbi.nlm.nih.gov/31361614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,34967562,The Effect of Gene Mutations on Metastasis and Overall Survival in Metastatic and Nonmetastatic Colon Cancers.,2021,10.31557/apjcp.2021.22.12.3839,https://pubmed.ncbi.nlm.nih.gov/34967562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,25303210,Regulation of the AbrA1/A2 two-component system in Streptomyces coelicolor and the potential of its deletion strain as a heterologous host for antibiotic production.,2014,10.1371/journal.pone.0109844,https://pubmed.ncbi.nlm.nih.gov/25303210/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,35309086,Platinum-based chemotherapy for pancreatic cancer: impact of mutations in the homologous recombination repair and Fanconi anemia genes.,2022,10.1177/17588359221083050,https://pubmed.ncbi.nlm.nih.gov/35309086/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,28242625,ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.,2017,10.1101/gad.292516.116,https://pubmed.ncbi.nlm.nih.gov/28242625/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,36896237,Evaluation of AlphaFold structure-based protein stability prediction on missense variations in cancer.,2023,10.3389/fgene.2023.1052383,https://pubmed.ncbi.nlm.nih.gov/36896237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,32444418,Genomic Methods Identify Homologous Recombination Deficiency in Pancreas Adenocarcinoma and Optimize Treatment Selection.,2020,10.1158/1078-0432.ccr-20-0418,https://pubmed.ncbi.nlm.nih.gov/32444418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,21799032,Modification of BRCA1-Associated Breast and Ovarian Cancer Risk by BRCA1-Interacting Genes.,2011,10.1158/0008-5472.can-11-0773,https://pubmed.ncbi.nlm.nih.gov/21799032/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,28254358,Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase.,2017,10.1016/j.dnarep.2017.02.010,https://pubmed.ncbi.nlm.nih.gov/28254358/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,22267201,Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.,2012,10.1038/ng.1051,https://pubmed.ncbi.nlm.nih.gov/22267201/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,18550271,"RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites.",2008,10.1016/j.canlet.2008.04.046,https://pubmed.ncbi.nlm.nih.gov/18550271/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ABRAXAS1,ENSG00000163322,Unsafe,24240112,"Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas.",2014,10.1158/1078-0432.ccr-13-2287,https://pubmed.ncbi.nlm.nih.gov/24240112/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,42773581,Clinical and Genetic Analysis of Pediatric Neurodevelopmental Disorders With Complex Chromosomal Rearrangements in Two Cases.,2026,10.1002/mgg3.70305,https://pubmed.ncbi.nlm.nih.gov/42773581/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,40537578,ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism.,2025,10.1038/s41594-025-01596-4,https://pubmed.ncbi.nlm.nih.gov/40537578/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,42827588,Diabetic cardiomyopathy as a disorder of proteostatic maladaptation: context-dependent ubiquitin-specific protease networks.,2026,10.3389/fcell.2026.1910665,https://pubmed.ncbi.nlm.nih.gov/42827588/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,40840647,Analysis of mouse lens morphological and proteomic abnormalities following deletion of the βB3-crystallin promoter.,2025,10.1016/j.exer.2025.110587,https://pubmed.ncbi.nlm.nih.gov/40840647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,41487520,Mitophagy-related gene TRIP13 predicts prognosis and immune response and promotes proliferation and migration &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; of clear cell renal cell carcinoma.,2025,10.3389/fphar.2025.1736086,https://pubmed.ncbi.nlm.nih.gov/41487520/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,40460554,Ubiquitin-specific protease 38 exacerbates diabetic cardiomyopathy via post-translational modification of ACAD11.,2025,10.1016/j.redox.2025.103704,https://pubmed.ncbi.nlm.nih.gov/40460554/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,39174697,ACAD10 and ACAD11 allow entry of 4-hydroxy fatty acids into β-oxidation.,2024,10.1007/s00018-024-05397-8,https://pubmed.ncbi.nlm.nih.gov/39174697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,42184630,Embryonic thermal programming combined with fractionated feeding induces early activation of hepatic lipid storage pathways in mule ducks.,2026,10.1016/j.psj.2026.107075,https://pubmed.ncbi.nlm.nih.gov/42184630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,41897862,Transcriptomic Analysis of High and Low Lipid Droplet Deposition Subpopulations of Chicken Preadipocytes Based on SSC Sorting.,2026,10.3390/ani16060885,https://pubmed.ncbi.nlm.nih.gov/41897862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,38839792,Structural basis for expanded substrate specificities of human long chain acyl-CoA dehydrogenase and related acyl-CoA dehydrogenases.,2024,10.1038/s41598-024-63027-6,https://pubmed.ncbi.nlm.nih.gov/38839792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,40553786,Prenatal microcystin-LR exposure alters pancreatic proteome and impairs insulin secretion in offspring mice.,2025,10.1016/j.toxlet.2025.06.009,https://pubmed.ncbi.nlm.nih.gov/40553786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,38297313,Establishment and validation of a novel peroxisome-related gene prognostic risk model in kidney clear cell carcinoma.,2024,10.1186/s12894-024-01404-z,https://pubmed.ncbi.nlm.nih.gov/38297313/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,39050798,Tangzhiping Decoction Improves Glucose and Lipid Metabolism and Exerts Protective Effects Against White Adipose Tissue Dysfunction in Prediabetic Mice.,2024,10.2147/dddt.s462603,https://pubmed.ncbi.nlm.nih.gov/39050798/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,41124021,"Inc/GFP chimera protein-based interactomics reveals host cellular interactions of Cps0558, a novel Chlamydia psittaci inclusion protein.",2025,10.1093/femspd/ftaf012,https://pubmed.ncbi.nlm.nih.gov/41124021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,40427335,Whole-Genome Resequencing Analysis of Copy Number Variations Associated with Athletic Performance in Grassland-Thoroughbred.,2025,10.3390/ani15101458,https://pubmed.ncbi.nlm.nih.gov/40427335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,38589566,Development and experimental validation of an energy metabolism-related gene signature for diagnosing of osteoporosis.,2024,10.1038/s41598-024-59062-y,https://pubmed.ncbi.nlm.nih.gov/38589566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,34135558,Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology.,2021,10.3748/wjg.v27.i21.2850,https://pubmed.ncbi.nlm.nih.gov/34135558/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,34868460,A Mitochondrial Dysfunction and Oxidative Stress Pathway-Based Prognostic Signature for Clear Cell Renal Cell Carcinoma.,2021,10.1155/2021/9939331,https://pubmed.ncbi.nlm.nih.gov/34868460/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,37541382,Long non-coding RNAs mediate the association between short-term PM2.5 exposure and circulating biomarkers of systemic inflammation.,2023,10.1016/j.envpol.2023.122299,https://pubmed.ncbi.nlm.nih.gov/37541382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,31443159,Transcriptional Response of Subcutaneous White Adipose Tissue to Acute Cold Exposure in Mice.,2019,10.3390/ijms20163968,https://pubmed.ncbi.nlm.nih.gov/31443159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,31256337,Analysis of longissimus muscle quality characteristics and associations with DNA methylation status in cattle.,2019,10.1007/s13258-019-00844-4,https://pubmed.ncbi.nlm.nih.gov/31256337/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACAD11,ENSG00000240303,Unsafe,21237683,Identification and characterization of new long chain acyl-CoA dehydrogenases.,2011,10.1016/j.ymgme.2010.12.005,https://pubmed.ncbi.nlm.nih.gov/21237683/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42527623,The short ACE2 isoform is upregulated in adipose tissue from women with obesity.,2026,10.1038/s41366-026-02177-1,https://pubmed.ncbi.nlm.nih.gov/42527623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,41303587,ACE2: Friend or Foe in Post-COVID-19 Neurodegeneration?,2025,10.3390/ijms262211104,https://pubmed.ncbi.nlm.nih.gov/41303587/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42652572,Association of the ACE2 rs879922 Polymorphism with Glaucoma Risk and Serum ACE2 Levels.,2026,10.3390/jcm15166168,https://pubmed.ncbi.nlm.nih.gov/42652572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,40576111,Angiotensin‑converting enzyme 2 expression in human tumors: Implications for prognosis and therapy (Review).,2025,10.3892/or.2025.8934,https://pubmed.ncbi.nlm.nih.gov/40576111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,41957813,Cerebrospinal fluid and frontal cortex TMPRSS2 and ACE2 protein levels differ in Down syndrome and Alzheimer's disease.,2026,10.1186/s40478-026-02289-9,https://pubmed.ncbi.nlm.nih.gov/41957813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42650256,Neuroprotective Potential of Peptide KSVSPKFLTG from &lt;i&gt;Magallana gigas&lt;/i&gt; via Activating the ACE2/Ang-(1-7)/Mas Axis in SHSY-5Y Cells.,2026,10.3390/antiox15080992,https://pubmed.ncbi.nlm.nih.gov/42650256/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42770297,Proximal tubule ACE2 mediates early responses to hypertension by regulating intrarenal RAS and sodium homeostasis.,2026,10.1172/jci.insight.179960,https://pubmed.ncbi.nlm.nih.gov/42770297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42747672,Tissue-specific alterations in ACE2 and TMPRSS2 expression following gender-affirming hormone therapy: a preliminary study.,2026,10.1007/s12020-026-04783-5,https://pubmed.ncbi.nlm.nih.gov/42747672/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42272146,ACE2 Expression and Clinical Biomarkers in COVID-19: Associations With Disease Severity.,2026,10.1155/pm/1013605,https://pubmed.ncbi.nlm.nih.gov/42272146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42653310,"Important Role of Renin-Angiotensin System and Vasopressin System in Cardiovascular, Metabolic and Psychogenic Disorders in Pregnancy and Early Postnatal Life: A Narrative Review.",2026,10.3390/ijms27167309,https://pubmed.ncbi.nlm.nih.gov/42653310/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42710476,ACE2 downregulation contributes to adverse cardiovascular and reproductive outcomes in female mice on high-fat diet.,2026,10.1152/ajpheart.00345.2026,https://pubmed.ncbi.nlm.nih.gov/42710476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,41906983,Therapeutic role of miR-296-5p in hypertensive stroke through ACE2-dependent Edn1 suppression.,2026,10.1080/00207454.2026.2652632,https://pubmed.ncbi.nlm.nih.gov/41906983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42707274,Rosmarinic acid mitigates stress-induced gastric ulcers by targeting the ACE2/GPX4 interaction.,2026,10.3389/fphar.2026.1891305,https://pubmed.ncbi.nlm.nih.gov/42707274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42734292,Age-related alterations in the brain ACE2/Ang-(1-7)/Mas receptor axis in normotensive and spontaneously hypertensive rats.,2026,10.1042/cs20261834,https://pubmed.ncbi.nlm.nih.gov/42734292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42714610,ACE2 and Parkinsonism‑related bone metabolic alterations: signaling pathways and hub gene analysis.,2026,10.1007/s00438-026-02511-2,https://pubmed.ncbi.nlm.nih.gov/42714610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42414498,Naturally occurring ACE2 stalk variants are differentially released from the cell.,2026,10.1038/s41598-026-60888-x,https://pubmed.ncbi.nlm.nih.gov/42414498/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42307333,"Expression of angiotensin-converting enzyme 2, transmembrane serine protease 2, and sirtuin 1 proteins in lungs of different age groups.",2026,10.36416/1806-3756/e20250127,https://pubmed.ncbi.nlm.nih.gov/42307333/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42547580,Cadherin 1 negatively regulates SARS-CoV-2 infection in the olfactory epithelium.,2026,10.1038/s44319-026-00880-8,https://pubmed.ncbi.nlm.nih.gov/42547580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,40597093,Development and characterization of a fully humanized ACE2 mouse model.,2025,10.1186/s12915-025-02293-w,https://pubmed.ncbi.nlm.nih.gov/40597093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42581377,Protective Arm of Renin-Angiotensin System: Evidence of Nephroprotective Effects Against Acute Kidney Injury.,2026,10.1111/apha.70292,https://pubmed.ncbi.nlm.nih.gov/42581377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42682883,Host cell entry receptors as pharmacological targets in respiratory viral infections: from biology to clinical translation.,2026,10.3389/fcimb.2026.1904701,https://pubmed.ncbi.nlm.nih.gov/42682883/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42695476,A Poly(lactic Acid)-Porphyrin-Cobalt Vaccine Adjuvant System Elicits Protein- or Peptide-Specific Humoral and Cellular Immunity.,2026,10.1002/adma.74905,https://pubmed.ncbi.nlm.nih.gov/42695476/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42913748,A yeast surface display platform for oral delivery of a SARS-CoV-2 receptor-binding domain dimer inducing mucosal and systemic immunity.,2026,10.1016/j.ijbiomac.2026.155006,https://pubmed.ncbi.nlm.nih.gov/42913748/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,41986366,SARS-CoV-2 vaccination and infection elicit cross-neutralizing responses against clade 3 and 4 sarbecoviruses.,2026,10.1038/s41467-026-71662-y,https://pubmed.ncbi.nlm.nih.gov/41986366/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42781491,Chimeric SARS-CoV-2 vaccine vectors stably incorporating the functional glycoprotein of VSV.,2026,10.1016/j.isci.2026.117521,https://pubmed.ncbi.nlm.nih.gov/42781491/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42519317,"FcγR-ACE2 cooperative antibody-dependent enhancement in human and veterinary coronaviruses: mechanistic insights, comparative immunology, and implications for nano-engineered immunomodulatory platforms.",2026,10.3389/fimmu.2026.1859321,https://pubmed.ncbi.nlm.nih.gov/42519317/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42879418,Evaluation of pre-Omicron population immunity for SARS-CoV-2 in the Household Influenza Vaccine Evaluation (HIVE) cohort.,2026,10.1371/journal.pone.0360506,https://pubmed.ncbi.nlm.nih.gov/42879418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42793280,Extracellular Vesicles as Molecular Regulators of Viral Infection: Implications for COVID-19 and Future Viral Pandemics.,2026,10.3390/cimb48090924,https://pubmed.ncbi.nlm.nih.gov/42793280/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42750109,Intelligent Programmable Membrane Nanosponge for Early Virus Blocking.,2026,10.1002/advs.77592,https://pubmed.ncbi.nlm.nih.gov/42750109/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42731688,"Assessment of the immune response induced by ChAdOx1 nCoV-19 Oxford-AstraZeneca, Sputnik V, and BNT162b2 Pfizer-BioNTech vaccines during the COVID-19 epidemic outbreak in the Mexican population: Gene expression of the cytokine storm.",2026,10.1016/j.meegid.2026.106025,https://pubmed.ncbi.nlm.nih.gov/42731688/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42627230,Novel African &lt;i&gt;Rhinolophus&lt;/i&gt; bat ACE2 sequences reveal the determinants of Afro-Eurasian sarbecovirus entry.,2026,10.1128/jvi.00540-26,https://pubmed.ncbi.nlm.nih.gov/42627230/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,41720818,A modular three in one mucosal vaccine against three antigenic clusters of ACE2 using sarbecoviruses.,2026,10.1038/s41541-026-01403-1,https://pubmed.ncbi.nlm.nih.gov/41720818/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42885535,A multiscale mechanical model for flexible spike protein-mediated SARS-CoV-2 viral entry into host cells.,2026,10.1039/d6sm00692b,https://pubmed.ncbi.nlm.nih.gov/42885535/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42339725,AI-aided design of multi-epitope peptide vaccine elicits cellular and humoral immunity to broad Omicron subvariants.,2026,10.24272/j.issn.2095-8137.2025.469,https://pubmed.ncbi.nlm.nih.gov/42339725/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42506605,Rationally Modified SARS-CoV-2 Spike Protein Impairs ACE2 Binding While Preserving Immunogenicity in Mice.,2026,10.3390/vaccines14070568,https://pubmed.ncbi.nlm.nih.gov/42506605/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,41997001,The immune response of the mRNA vaccine CS-2034 as a heterologous booster before and after breakthrough infection: A follow-up study.,2026,10.1016/j.vaccine.2026.128575,https://pubmed.ncbi.nlm.nih.gov/41997001/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42347644,Larger Acute Phase Reactions Are Associated with Immunogenicity of an Adjuvanted Recombinant Receptor Binding Domain Protein Vaccine Against SARS-CoV-2 in Rhesus Monkeys.,2026,10.3390/vaccines14060523,https://pubmed.ncbi.nlm.nih.gov/42347644/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,41796239,Angiotensin‑converting enzyme 2 as an immune and prognostic biomarker in colorectal cancer.,2026,10.1038/s41598-026-43588-4,https://pubmed.ncbi.nlm.nih.gov/41796239/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,42099041,Kidney Transplant Recipients Develop Nasal Mucosal Antibodies to SARS-CoV-2 With ACE2-Inhibiting Activity Following mRNA Vaccination.,2026,10.1111/tid.70230,https://pubmed.ncbi.nlm.nih.gov/42099041/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,41931545,In silico design of a novel multi-epitope mRNA vaccine candidate for BtHKU5-CoV-2 using immunoinformatics.,2026,10.1371/journal.pntd.0013517,https://pubmed.ncbi.nlm.nih.gov/41931545/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,33432184,A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection.,2021,10.1038/s41588-020-00759-x,https://pubmed.ncbi.nlm.nih.gov/33432184/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,32715618,The protein expression profile of ACE2 in human tissues.,2020,10.15252/msb.20209610,https://pubmed.ncbi.nlm.nih.gov/32715618/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,32425701,Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract.,2020,10.1016/j.devcel.2020.05.012,https://pubmed.ncbi.nlm.nih.gov/32425701/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,32404436,TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes.,2020,10.1126/sciimmunol.abc3582,https://pubmed.ncbi.nlm.nih.gov/32404436/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,32358202,SARS-CoV-2 productively infects human gut enterocytes.,2020,10.1126/science.abc1669,https://pubmed.ncbi.nlm.nih.gov/32358202/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,32413319,SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.,2020,10.1016/j.cell.2020.04.035,https://pubmed.ncbi.nlm.nih.gov/32413319/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,32327758,SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.,2020,10.1038/s41591-020-0868-6,https://pubmed.ncbi.nlm.nih.gov/32327758/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,32333915,"Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2.",2020,10.1016/j.jaci.2020.04.009,https://pubmed.ncbi.nlm.nih.gov/32333915/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,32170560,Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection.,2020,10.1007/s11684-020-0754-0,https://pubmed.ncbi.nlm.nih.gov/32170560/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,18424768,A protein complex in the brush-border membrane explains a Hartnup disorder allele.,2008,10.1096/fj.08-107300,https://pubmed.ncbi.nlm.nih.gov/18424768/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,15671045,Myocardial infarction increases ACE2 expression in rat and humans.,2005,10.1093/eurheartj/ehi114,https://pubmed.ncbi.nlm.nih.gov/15671045/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,15231706,"The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis.",2004,10.1210/en.2004-0443,https://pubmed.ncbi.nlm.nih.gov/15231706/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,15141377,"Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.",2004,10.1002/path.1570,https://pubmed.ncbi.nlm.nih.gov/15141377/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,12459472,"Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme.",2002,10.1016/s0014-5793(02)03640-2,https://pubmed.ncbi.nlm.nih.gov/12459472/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,10924499,A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase.,2000,10.1074/jbc.m002615200,https://pubmed.ncbi.nlm.nih.gov/10924499/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACE2,ENSG00000130234,Unsafe,10969042,A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.,2000,10.1161/01.res.87.5.e1,https://pubmed.ncbi.nlm.nih.gov/10969042/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,41053718,ACOXL-AS1's pan-cancer dynamics and its proliferative impact on endometrial endometrioid carcinoma.,2025,10.1186/s12885-025-15005-y,https://pubmed.ncbi.nlm.nih.gov/41053718/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,41079198,"Association of acyl-CoA oxidase-like gene polymorphisms with risk, onset age, and beta-cell function of type 1 diabetes in Chinese.",2025,10.3389/fendo.2025.1551159,https://pubmed.ncbi.nlm.nih.gov/41079198/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,42650107,Transcriptome-Based Six-Gene Fatty Acid Metabolism Signature for Prognosis and Predicted Immunotherapy Response in Lung Adenocarcinoma: Cross-Population Validation.,2026,10.3390/genes17080914,https://pubmed.ncbi.nlm.nih.gov/42650107/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,41292676,"Unraveling the Interplay Between Alcohol, Immunity, and Gastric Cancer: A Genomic Approach.",2025,10.1002/fsn3.71260,https://pubmed.ncbi.nlm.nih.gov/41292676/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,37173646,Nonnegative matrix factorization analysis and multiple machine learning methods identified IL17C and ACOXL as novel diagnostic biomarkers for atherosclerosis.,2023,10.1186/s12859-023-05244-w,https://pubmed.ncbi.nlm.nih.gov/37173646/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,41466414,"Genome-wide association for sarcoidosis identifies novel risk loci and genetic heritability in African and European ancestries: a meta-analysis from the Finngen, Million Veteran Program, UK Biobank, and Biobank Japan datasets.",2025,10.1186/s13023-025-04097-1,https://pubmed.ncbi.nlm.nih.gov/41466414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,39930543,Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci.,2025,10.1186/s13059-025-03492-y,https://pubmed.ncbi.nlm.nih.gov/39930543/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,38852153,Proliferative verrucous and homogeneous Leukoplakias exhibit differential methylation patterns.,2025,10.1111/odi.15028,https://pubmed.ncbi.nlm.nih.gov/38852153/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,41407879,Whole-genome sequencing GWAS reveals bovine genomic effects on enteric methane emissions in beef cattle.,2025,10.1038/s41598-025-32815-z,https://pubmed.ncbi.nlm.nih.gov/41407879/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,38275594,Genome-Wide Association Analysis of Reproductive Traits in Chinese Holstein Cattle.,2023,10.3390/genes15010012,https://pubmed.ncbi.nlm.nih.gov/38275594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,36631795,Proteomics investigation of human sera for determination of postoperative indicators of pulmonary cystic echinococcosis.,2023,10.1186/s13019-023-02109-4,https://pubmed.ncbi.nlm.nih.gov/36631795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,37796199,Analysis and experimental validation of fatty acid metabolism-related genes prostacyclin synthase (PTGIS) in endometrial cancer.,2023,10.18632/aging.205080,https://pubmed.ncbi.nlm.nih.gov/37796199/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,38085674,Two lncRNA signatures with cuproptosis as a novel prognostic model and clinicopathological value for endometrioid endometrial adenocarcinoma.,2023,10.18632/aging.205299,https://pubmed.ncbi.nlm.nih.gov/38085674/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,38911262,Analysis of 206 whole-genome resequencing reveals selection signatures associated with breed-specific traits in Hu sheep.,2024,10.1111/eva.13697,https://pubmed.ncbi.nlm.nih.gov/38911262/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,38367693,Histone H3K36me3 mediates the genomic instability of Benzo[a]pyrene in human bronchial epithelial cells.,2024,10.1016/j.envpol.2024.123564,https://pubmed.ncbi.nlm.nih.gov/38367693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,36199579,Transcriptome profiles of fatty acid metabolism-related genes and immune infiltrates identify hot tumors for immunotherapy in cutaneous melanoma.,2022,10.3389/fgene.2022.860067,https://pubmed.ncbi.nlm.nih.gov/36199579/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,26237329,"Analysis of the Human Prostate-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling Identifies TMEM79 and ACOXL as Two Putative, Diagnostic Markers in Prostate Cancer.",2015,10.1371/journal.pone.0133449,https://pubmed.ncbi.nlm.nih.gov/26237329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,33841008,Anti-tumor activities of Panax quinquefolius saponins and potential biomarkers in prostate cancer.,2021,10.1016/j.jgr.2019.12.007,https://pubmed.ncbi.nlm.nih.gov/33841008/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,35360871,Resequencing and Signatures of Selective Scans Point to Candidate Genetic Variants for Hair Length Traits in Long-Haired and Normal-Haired Tianzhu White Yak.,2022,10.3389/fgene.2022.798076,https://pubmed.ncbi.nlm.nih.gov/35360871/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,35582412,Lipid metabolism-related gene prognostic index (LMRGPI) reveals distinct prognosis and treatment patterns for patients with early-stage pulmonary adenocarcinoma.,2022,10.7150/ijms.71267,https://pubmed.ncbi.nlm.nih.gov/35582412/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,38616327,"Characterization and validation of fatty acid metabolism-related genes predicting prognosis, immune infiltration, and drug sensitivity in endometrial cancer.",2024,10.1002/bab.2586,https://pubmed.ncbi.nlm.nih.gov/38616327/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,33166901,"Individual and mixture toxicity of chromium and copper in development, oxidative stress, lipid metabolism and apoptosis of Bufo gargarizans embryos.",2020,10.1016/j.aquatox.2020.105671,https://pubmed.ncbi.nlm.nih.gov/33166901/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,31197149,Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection.,2019,10.1038/s41467-019-10525-1,https://pubmed.ncbi.nlm.nih.gov/31197149/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,33751038,Sequencing at lymphoid neoplasm susceptibility loci maps six myeloma risk genes.,2021,10.1093/hmg/ddab066,https://pubmed.ncbi.nlm.nih.gov/33751038/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACOXL,ENSG00000153093,Unsafe,25608926,Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.,2015,10.1038/ncomms6966,https://pubmed.ncbi.nlm.nih.gov/25608926/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,41099151,Cancer-testis antigen ACRBP: Cytotoxic response to its HLA-A2 restricted peptide and immune features in ovarian cancer.,2025,10.1080/21645515.2025.2557096,https://pubmed.ncbi.nlm.nih.gov/41099151/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,41913266,Testis-specific lncRNA Teshl regulates acrosome biogenesis to maintain sperm structure and function.,2026,10.1186/s13578-026-01563-6,https://pubmed.ncbi.nlm.nih.gov/41913266/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,41398765,A cancer-testis antigen signature for predicting prognosis and response to immunotherapy in acute myeloid leukemia.,2025,10.1097/md.0000000000046374,https://pubmed.ncbi.nlm.nih.gov/41398765/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,40858886,Combination of knockout serum replacement and plasma rich in growth factors does not support in vitro spermatogenesis in mice.,2025,10.1038/s41598-025-16502-7,https://pubmed.ncbi.nlm.nih.gov/40858886/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,37835834,Characterization of Cancer/Testis Antigens as Prognostic Markers of Ovarian Cancer.,2023,10.3390/diagnostics13193092,https://pubmed.ncbi.nlm.nih.gov/37835834/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,34528758,Cancer-testis antigen ACRBP expression and serum immunoreactivity in ovarian cancer: Its association with prognosis.,2021,10.1002/iid3.534,https://pubmed.ncbi.nlm.nih.gov/34528758/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,39849580,In vitro sperm generation from immature mouse testicular tissue using plasma rich in growth factors.,2025,10.1186/s13287-025-04136-5,https://pubmed.ncbi.nlm.nih.gov/39849580/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,38847481,Male infertility and perfluoroalkyl and poly-fluoroalkyl substances: evidence for alterations in phosphorylation of proteins and fertility-related functional attributes in bull spermatozoa†.,2024,10.1093/biolre/ioae089,https://pubmed.ncbi.nlm.nih.gov/38847481/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,37551308,Expression and clinical importance of a newly discovered alternative splice variant of the gene for acrosin binding protein found in human brain tumors.,2020,10.1515/abm-2020-0033,https://pubmed.ncbi.nlm.nih.gov/37551308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,37694147,WNK1 is required during male pachynema to sustain fertility.,2023,10.1016/j.isci.2023.107616,https://pubmed.ncbi.nlm.nih.gov/37694147/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,37118964,Differential Proteomic Analysis of Human Sperm: A Systematic Review to Identify Candidate Targets to Monitor Sperm Quality.,2024,10.5534/wjmh.220262,https://pubmed.ncbi.nlm.nih.gov/37118964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,35717571,Mini Bioreactor Can Support In Vitro Spermatogenesis of Mouse Testicular Tissue.,2022,10.22074/cellj.2022.8053,https://pubmed.ncbi.nlm.nih.gov/35717571/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,34377237,Combined treatment with epigenetic agents enhances anti-tumor activity of T cells by upregulating the ACRBP expression in hepatocellular carcinoma.,2021,,https://pubmed.ncbi.nlm.nih.gov/34377237/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,37151112,Integrated testis transcriptome and whole genome analysis of sexual maturity in Large White and Tongcheng pigs.,2023,10.1111/rda.14373,https://pubmed.ncbi.nlm.nih.gov/37151112/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,36220369,Improving the process of spermatogenesis in azoospermic mice using spermatogonial stem cells co-cultured with epididymosomes in three-dimensional culture system.,2022,10.1016/j.lfs.2022.121057,https://pubmed.ncbi.nlm.nih.gov/36220369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,34086710,ACRBP (Sp32) is involved in priming sperm for the acrosome reaction and the binding of sperm to the zona pellucida in a porcine model.,2021,10.1371/journal.pone.0251973,https://pubmed.ncbi.nlm.nih.gov/34086710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,34070710,Dysregulation of the Acrosome Formation Network by 8-oxoguanine (8-oxoG) in Infertile Sperm: A Case Report with Advanced Techniques.,2021,10.3390/ijms22115857,https://pubmed.ncbi.nlm.nih.gov/34070710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,32497486,Efficacy of co-immunization with the DNA and peptide vaccines containing SYCP1 and ACRBP epitopes in a murine triple-negative breast cancer model.,2021,10.1080/21645515.2020.1763693,https://pubmed.ncbi.nlm.nih.gov/32497486/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,37046330,New insights into posttranslational modifications of proteins during bull sperm capacitation.,2023,10.1186/s12964-023-01080-w,https://pubmed.ncbi.nlm.nih.gov/37046330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,35863763,Testis-specific serine protease PRSS54 regulates acrosomal granule localization and sperm head morphogenesis in mice†.,2022,10.1093/biolre/ioac146,https://pubmed.ncbi.nlm.nih.gov/35863763/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,34690620,Implementation of Vaccinomics and In-Silico Approaches to Construct Multimeric Based Vaccine Against Ovarian Cancer.,2021,10.1007/s10989-021-10294-w,https://pubmed.ncbi.nlm.nih.gov/34690620/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,31499268,"Production, purification, and in vivo evaluation of a novel multiepitope peptide vaccine consisted of immunodominant epitopes of SYCP1 and ACRBP antigens as a prophylactic melanoma vaccine.",2019,10.1016/j.intimp.2019.105872,https://pubmed.ncbi.nlm.nih.gov/31499268/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,24457462,"Expression of cancer-testis antigens MAGEA1, MAGEA3, ACRBP, PRAME, SSX2, and CTAG2 in myxoid and round cell liposarcoma.",2014,10.1038/modpathol.2013.244,https://pubmed.ncbi.nlm.nih.gov/24457462/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,20876808,Tumor antigen acrosin binding protein normalizes mitotic spindle function to promote cancer cell proliferation.,2010,10.1158/0008-5472.can-10-0840,https://pubmed.ncbi.nlm.nih.gov/20876808/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,26464818,Upregulation of RHOXF2 and ODF4 Expression in Breast Cancer Tissues.,2015,10.22074/cellj.2015.8,https://pubmed.ncbi.nlm.nih.gov/26464818/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,30917866,In vitro transplantation of spermatogonial stem cells isolated from human frozen-thawed testis tissue can induce spermatogenesis under 3-dimensional tissue culture conditions.,2019,10.1186/s40659-019-0223-x,https://pubmed.ncbi.nlm.nih.gov/30917866/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRBP,ENSG00000111644,Unsafe,11248070,Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen.,2001,10.1073/pnas.041625098,https://pubmed.ncbi.nlm.nih.gov/11248070/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,41338461,ZNF280A and ACRV1 enhance aerobic glycolysis and drive ovarian cancer progression via the PI3K/AKT signaling pathway.,2026,10.1016/j.jbc.2025.110993,https://pubmed.ncbi.nlm.nih.gov/41338461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,42450078,"APOA1, DEFB103A_DEFB103B and DSG3 Are Novel Circulating Biomarkers of Psoriasis.",2026,10.3390/ijms27135805,https://pubmed.ncbi.nlm.nih.gov/42450078/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,42140156,Arginine and putrescine ameliorate heat stress-induced testicular inflammation and apoptosis via inhibiting endoplasmic reticulum stress in mice.,2026,10.1016/j.theriogenology.2026.117987,https://pubmed.ncbi.nlm.nih.gov/42140156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,40787865,[NSD1 regulates H3K36me2 in the pathogenesis of non-obstructive azoospermia].,2025,,https://pubmed.ncbi.nlm.nih.gov/40787865/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,41537300,"The expression of genes KRAS, DPM1, ACRV1, and MBD3L2 in the saliva as potential tumor markers in the detection of pancreatic cancer.",2025,10.5604/01.3001.0055.4390,https://pubmed.ncbi.nlm.nih.gov/41537300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,38785936,Unlocking Genetic Mysteries during the Epic Sperm Journey toward Fertilization: Further Expanding &lt;i&gt;Cre&lt;/i&gt; Mouse Lines.,2024,10.3390/biom14050529,https://pubmed.ncbi.nlm.nih.gov/38785936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,37239343,Generation and Characterization of a Transgenic Mouse That Specifically Expresses the Cre Recombinase in Spermatids.,2023,10.3390/genes14050983,https://pubmed.ncbi.nlm.nih.gov/37239343/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,38697008,Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice.,2024,10.1016/j.jri.2024.104252,https://pubmed.ncbi.nlm.nih.gov/38697008/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,36793255,Transcriptional regulation of spatiotemporal gene expression within the seminiferous epithelium: Mouse Acrv1 gene as a model.,2023,10.1111/andr.13410,https://pubmed.ncbi.nlm.nih.gov/36793255/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,37118964,Differential Proteomic Analysis of Human Sperm: A Systematic Review to Identify Candidate Targets to Monitor Sperm Quality.,2024,10.5534/wjmh.220262,https://pubmed.ncbi.nlm.nih.gov/37118964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,37087050,Germ Cell-Specific Proteins AKAP4 and ASPX Facilitate Identification of Rare Spermatozoa in Non-Obstructive Azoospermia.,2023,10.1016/j.mcpro.2023.100556,https://pubmed.ncbi.nlm.nih.gov/37087050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,31290539,A 50-bp enhancer of the mouse acrosomal vesicle protein 1 gene activates round spermatid-specific transcription in vivo†.,2019,10.1093/biolre/ioz115,https://pubmed.ncbi.nlm.nih.gov/31290539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,39046915,Synaptotagmin 13 Could Drive the Progression of Esophageal Squamous Cell Carcinoma Through Upregulating ACRV1.,2024,10.1089/dna.2024.0106,https://pubmed.ncbi.nlm.nih.gov/39046915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,36861402,"Momelotinib (JAK1/JAK2/ACVR1 inhibitor): mechanism of action, clinical trial reports, and therapeutic prospects beyond myelofibrosis.",2023,10.3324/haematol.2022.282612,https://pubmed.ncbi.nlm.nih.gov/36861402/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,33507524,The Germ Cell-Specific Markers ZPBP2 and PGK2 in Testicular Biopsies Can Predict the Presence as well as the Quality of Sperm in Non-obstructive Azoospermia Patients.,2021,10.1007/s43032-020-00427-9,https://pubmed.ncbi.nlm.nih.gov/33507524/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,28278534,Transcription and Splicing Factor TDP-43: Role in Regulation of Gene Expression in Testis.,2017,10.1055/s-0037-1599088,https://pubmed.ncbi.nlm.nih.gov/28278534/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,34125190,Hypomorphic and hypermorphic mouse models of Fsip2 indicate its dosage-dependent roles in sperm tail and acrosome formation.,2021,10.1242/dev.199216,https://pubmed.ncbi.nlm.nih.gov/34125190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,32758798,Acrosomal marker SP-10 (gene name Acrv1) for staging of the cycle of seminiferous epithelium in the stallion.,2020,10.1016/j.theriogenology.2020.06.046,https://pubmed.ncbi.nlm.nih.gov/32758798/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,28600885,Immunolocalization of TAR DNA-binding protein of 43 kDa (TDP-43) in mouse seminiferous epithelium.,2017,10.1002/mrd.22851,https://pubmed.ncbi.nlm.nih.gov/28600885/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,36084736,Combination of high-fat diet and cadmium impairs testicular spermatogenesis in an m6A-YTHDF2-dependent manner.,2022,10.1016/j.envpol.2022.120112,https://pubmed.ncbi.nlm.nih.gov/36084736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,21488928,Developmental expression of ACRV1 in humans and mice.,2012,10.1111/j.1439-0272.2010.01095.x,https://pubmed.ncbi.nlm.nih.gov/21488928/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,28398669,Evaluation of Culture Time and Media in an In Vitro Testis Organ Culture System.,2017,10.1002/bdr2.1002,https://pubmed.ncbi.nlm.nih.gov/28398669/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,25158006,The acrosomal protein SP-10 (Acrv1) is an ideal marker for staging of the cycle of seminiferous epithelium in the mouse.,2014,10.1002/mrd.22358,https://pubmed.ncbi.nlm.nih.gov/25158006/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACRV1,ENSG00000134940,Unsafe,1765564,Assignment of the gene for human intra-acrosomal protein SP-10 to the p12----q13 region of chromosome 11.,1991,10.1002/j.1939-4640.1991.tb01601.x,https://pubmed.ncbi.nlm.nih.gov/1765564/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,42541488,"Sodium Overload-Related Molecular Subtypes and a Four-Gene Prognostic Signature Predict Survival, Immune Landscape, and Therapeutic Response in Acute Myeloid Leukemia.",2026,10.1002/mc.70158,https://pubmed.ncbi.nlm.nih.gov/42541488/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,41783764,Adrenal adenomata displaying mild autonomous cortisol secretion: a service evaluation of cardiometabolic profile routinely screened patients.,2026,10.1097/xce.0000000000000357,https://pubmed.ncbi.nlm.nih.gov/41783764/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,42412387,Mitochondrial dysfunction in peri-implantitis: bioinformatics and machine learning analysis with in vivo experiment.,2026,10.1007/s10266-026-01487-0,https://pubmed.ncbi.nlm.nih.gov/42412387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,42436792,Toll-like receptor 9 arginine methylation promotes ferroptosis in prostate cancer through the NRF2/GPX4 signaling pathway.,2026,10.21037/tau-2026-1-0089,https://pubmed.ncbi.nlm.nih.gov/42436792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,40581718,Regulation of 15-PGDH by ACSM1 in modulating PGE2 signaling and ECM remodeling in prostate cancer.,2025,10.1007/s12032-025-02866-3,https://pubmed.ncbi.nlm.nih.gov/40581718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,41543497,"Landscape of Allele-Specific Expression in Prostate Cancer Reveals Recurrent, Stage-Specific Events in AR Signaling and Resistance Pathways.",2026,10.1158/1541-7786.mcr-25-0754,https://pubmed.ncbi.nlm.nih.gov/41543497/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,40596853,Identification of candidate proteins influencing spermatogenesis in Shandong black cattle via integrated multiomics analysis.,2025,10.1186/s12864-025-11825-1,https://pubmed.ncbi.nlm.nih.gov/40596853/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,41139737,MOGAT2 suppresses colorectal cancer progression through ACSM1-mediated lipid metabolic reprogramming.,2025,10.1007/s10142-025-01739-2,https://pubmed.ncbi.nlm.nih.gov/41139737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,40323471,Targeting miR-144-5p/ACSM1 Axis Alleviates Doxorubicin-Induced Heart Failure by Inhibiting Lipid Peroxidation.,2025,10.1007/s11596-025-00053-z,https://pubmed.ncbi.nlm.nih.gov/40323471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,39342516,METTL3-mediated m6A modification of ZNF384 promotes hepatocellular carcinoma progression by transcriptionally activating ACSM1.,2025,10.1007/s12094-024-03701-3,https://pubmed.ncbi.nlm.nih.gov/39342516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,41605187,Regulation of Lipid Biology-Associated Gene Expression in Granulosa Cells in Hyperandrogenic PCOS: A Possible Link Between Dyslipidemia and Hyperandrogenism.,2026,10.1002/lipd.70035,https://pubmed.ncbi.nlm.nih.gov/41605187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,39316049,RIPK4 promotes oxidative stress and ferroptotic death through the downregulation of ACSM1.,2024,10.1073/pnas.2410628121,https://pubmed.ncbi.nlm.nih.gov/39316049/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,35530294,Oncogenic ACSM1 in prostate cancer is through metabolic and extracellular matrix-receptor interaction signaling pathways.,2022,,https://pubmed.ncbi.nlm.nih.gov/35530294/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,39578562,Utilizing integrated bioinformatics and machine learning approaches to elucidate biomarkers linking sepsis to fatty acid metabolism-associated genes.,2024,10.1038/s41598-024-80550-8,https://pubmed.ncbi.nlm.nih.gov/39578562/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,37442233,ISL1 regulates lung branching morphogenesis via Shh signaling pathway.,2023,10.1016/j.jbc.2023.105034,https://pubmed.ncbi.nlm.nih.gov/37442233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,38944914,GRIN3A: A biomarker associated with a cribriform pattern and poor prognosis in prostate cancer.,2024,10.1016/j.neo.2024.101023,https://pubmed.ncbi.nlm.nih.gov/38944914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,40571113,Role of low-dose cadmium exposure to the pathogenesis of gestational diabetes mellitus.,2025,10.1016/j.envpol.2025.126718,https://pubmed.ncbi.nlm.nih.gov/40571113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,37240946,"Comprehensive Analysis of Purine-Metabolism-Related Gene Signature for Predicting Ovarian Cancer Prognosis, Immune Landscape, and Potential Treatment Options.",2023,10.3390/jpm13050776,https://pubmed.ncbi.nlm.nih.gov/37240946/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,34436670,Complete lung agenesis caused by complex genomic rearrangements with neo-TAD formation at the SHH locus.,2021,10.1007/s00439-021-02344-6,https://pubmed.ncbi.nlm.nih.gov/34436670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,40941311,"Population Genetic Structure, Historical Effective Population Size, and Dairy Trait Selection Signatures in Chinese Red Steppe and Holstein Cattle.",2025,10.3390/ani15172516,https://pubmed.ncbi.nlm.nih.gov/40941311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,36356814,Evaluation of digestate-derived biochar to alleviate ammonia inhibition during long-term anaerobic digestion of food waste.,2023,10.1016/j.chemosphere.2022.137150,https://pubmed.ncbi.nlm.nih.gov/36356814/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,37547609,Gene expression signatures associated with chronic endometritis revealed by RNA sequencing.,2023,10.3389/fmed.2023.1185284,https://pubmed.ncbi.nlm.nih.gov/37547609/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,34100479,Abundance of solute carrier family 27 member 6 (SLC27A6) in the bovine mammary gland alters fatty acid metabolism.,2021,10.1039/d0fo03289a,https://pubmed.ncbi.nlm.nih.gov/34100479/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,31588660,Prostate Cancer Risk Stratification in Men With a Clinical Suspicion of Prostate Cancer Using a Unique Biparametric MRI and Expression of 11 Genes in Apparently Benign Tissue: Evaluation Using Machine-Learning Techniques.,2020,10.1002/jmri.26945,https://pubmed.ncbi.nlm.nih.gov/31588660/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,25028604,A gene expression estimator of intramuscular fat percentage for use in both cattle and sheep.,2014,10.1186/2049-1891-5-35,https://pubmed.ncbi.nlm.nih.gov/25028604/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,26857646,Stratification of aggressive prostate cancer from indolent disease-Prospective controlled trial utilizing expression of 11 genes in apparently benign tissue.,2016,10.1016/j.urolonc.2015.12.014,https://pubmed.ncbi.nlm.nih.gov/26857646/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,21459115,Virucidal activity of the dendrimer microbicide SPL7013 against HIV-1.,2011,10.1016/j.antiviral.2011.03.186,https://pubmed.ncbi.nlm.nih.gov/21459115/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,27672559,Behavioral and omics analyses study on potential involvement of dipeptide balenine through supplementation in diet of senescence-accelerated mouse prone 8.,2016,10.1016/j.gdata.2016.09.004,https://pubmed.ncbi.nlm.nih.gov/27672559/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,19393583,Molecular characterization of apocrine carcinoma of the breast: validation of an apocrine protein signature in a well-defined cohort.,2009,10.1016/j.molonc.2009.01.005,https://pubmed.ncbi.nlm.nih.gov/19393583/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,18788913,Bioinformatic prediction programs underestimate the frequency of CXCR4 usage by R5X4 HIV type 1 in brain and other tissues.,2008,10.1089/aid.2008.0009,https://pubmed.ncbi.nlm.nih.gov/18788913/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACSM1,ENSG00000166743,Unsafe,12021361,Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate.,2002,10.1128/jvi.76.12.6277-6292.2002,https://pubmed.ncbi.nlm.nih.gov/12021361/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT2,ENSG00000169717,Unsafe,40811009,ACTRT2 deficiency increases spermatogonia vulnerability to ferroptosis.,2025,10.1093/molehr/gaaf041,https://pubmed.ncbi.nlm.nih.gov/40811009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT2,ENSG00000169717,Unsafe,41610073,"Methylation-specific, universal, and highly sensitive identification of ctDNA in prostate cancer by multiplex droplet digital PCR.",2026,10.1371/journal.pone.0340786,https://pubmed.ncbi.nlm.nih.gov/41610073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT2,ENSG00000169717,Unsafe,42450346,Evaluation of a Methylated Circulating Tumour DNA Panel for Detection and Disease Stratification in Prostate Cancer.,2026,10.3390/ijms27136081,https://pubmed.ncbi.nlm.nih.gov/42450346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT2,ENSG00000169717,Unsafe,42286492,Diversity of molecular karyotypes of 234 pediatric patients with autism spectrum disorder in chromosomal microarray analysis.,2026,10.1186/s12888-026-08263-y,https://pubmed.ncbi.nlm.nih.gov/42286492/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT2,ENSG00000169717,Unsafe,41668650,Actin-related protein T3 is required for acrosome biogenesis and sperm function in mice.,2026,10.1242/dev.205283,https://pubmed.ncbi.nlm.nih.gov/41668650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT2,ENSG00000169717,Unsafe,35751016,Ectopic expression of a combination of 5 genes detects high risk forms of T-cell acute lymphoblastic leukemia.,2022,10.1186/s12864-022-08688-1,https://pubmed.ncbi.nlm.nih.gov/35751016/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT2,ENSG00000169717,Unsafe,32787870,Effect of transient scrotal hyperthermia on human sperm: an iTRAQ-based proteomic analysis.,2020,10.1186/s12958-020-00640-w,https://pubmed.ncbi.nlm.nih.gov/32787870/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT2,ENSG00000169717,Unsafe,38414365,Deletion of ACTRT1 is associated with male infertility as sperm acrosomal ultrastructural defects and fertilization failure in human.,2024,10.1093/humrep/deae031,https://pubmed.ncbi.nlm.nih.gov/38414365/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT2,ENSG00000169717,Unsafe,38179408,Whole genome sequencing reveals population diversity and variation in HIV-1 specific host genes.,2023,10.3389/fgene.2023.1290624,https://pubmed.ncbi.nlm.nih.gov/38179408/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT2,ENSG00000169717,Unsafe,35616329,Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice.,2022,10.1242/dev.200489,https://pubmed.ncbi.nlm.nih.gov/35616329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT2,ENSG00000169717,Unsafe,31122248,Exome-wide search and functional annotation of genes associated in patients with severe tick-borne encephalitis in a Russian population.,2019,10.1186/s12920-019-0503-x,https://pubmed.ncbi.nlm.nih.gov/31122248/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT2,ENSG00000169717,Unsafe,25293813,Proteomic pattern changes associated with obesity-induced asthenozoospermia.,2015,10.1111/andr.289,https://pubmed.ncbi.nlm.nih.gov/25293813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT3,ENSG00000184378,Unsafe,42330090,Pathogenic variants in ACTRT3 lead to male infertility characterized by fertilization defects.,2026,10.1093/humrep/deag097,https://pubmed.ncbi.nlm.nih.gov/42330090/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT3,ENSG00000184378,Unsafe,41668650,Actin-related protein T3 is required for acrosome biogenesis and sperm function in mice.,2026,10.1242/dev.205283,https://pubmed.ncbi.nlm.nih.gov/41668650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT3,ENSG00000184378,Unsafe,42201020,Regulatory Variation at TERT and TERC Shows Limited Association with Early-Onset Alzheimer's Disease in Carriers of the Mexican Founder Mutation &lt;i&gt;PSEN1&lt;/i&gt; A431E.,2026,10.3390/medsci14020228,https://pubmed.ncbi.nlm.nih.gov/42201020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT3,ENSG00000184378,Unsafe,39425105,Plasma genome-wide mendelian randomization identifies potentially causal genes in idiopathic pulmonary fibrosis.,2024,10.1186/s12931-024-03008-5,https://pubmed.ncbi.nlm.nih.gov/39425105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT3,ENSG00000184378,Unsafe,39910817,Unraveling the genetic landscape of susceptibility to multiple primary cancers.,2025,10.1016/j.xhgg.2025.100413,https://pubmed.ncbi.nlm.nih.gov/39910817/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT3,ENSG00000184378,Unsafe,34869336,"Loss of Profilin3 Impairs Spermiogenesis by Affecting Acrosome Biogenesis, Autophagy, Manchette Development and Mitochondrial Organization.",2021,10.3389/fcell.2021.749559,https://pubmed.ncbi.nlm.nih.gov/34869336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT3,ENSG00000184378,Unsafe,18692047,Nuclear localization of profilin III-ArpM1 complex in mouse spermiogenesis.,2008,10.1016/j.febslet.2008.07.058,https://pubmed.ncbi.nlm.nih.gov/18692047/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACTRT3,ENSG00000184378,Unsafe,11750065,Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin.,2001,10.1016/s0167-4781(01)00315-3,https://pubmed.ncbi.nlm.nih.gov/11750065/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,42803598,INHBB Promotes Colorectal Cancer Progression by Inducing CD8&lt;sup&gt;+&lt;/sup&gt; T Cell Exhaustion via the ACVR2B-SMAD Signaling Axis.,2026,10.1111/cas.70542,https://pubmed.ncbi.nlm.nih.gov/42803598/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,42506334,Mechanotransduction Failure and Molecular Rescue in Gastric Cancer: Kinetotherapy Across the IL-6/STAT3-Myostatin/ACVR2B-Akt/mTOR Axis.,2026,10.3390/medsci14030365,https://pubmed.ncbi.nlm.nih.gov/42506334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,41298802,Identification of causal plasma proteins and targeted therapy for primary hepatic carcinoma via proteome-wide Mendelian randomization.,2025,10.1038/s42003-025-09274-3,https://pubmed.ncbi.nlm.nih.gov/41298802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,41596688,Integrated Transcriptomic and Machine Learning Analysis Reveals Immune-Related Regulatory Networks in Anti-NMDAR Encephalitis.,2026,10.3390/ijms27021044,https://pubmed.ncbi.nlm.nih.gov/41596688/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,39254854,LncRNA ACVR2B-as1 interacts with ALDOA to regulate the self-renewal and apoptosis of human spermatogonial stem cells by controlling glycolysis activity.,2024,10.1007/s00018-024-05414-w,https://pubmed.ncbi.nlm.nih.gov/39254854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,41949886,Receptivity of the human male and female fetal caudal genital ligament to gonadal hormones.,2026,10.1093/reprod/xaag040,https://pubmed.ncbi.nlm.nih.gov/41949886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,40144023,Expression and distribution of activin-follistatin-inhibin axis in the urinary bladder.,2025,10.3389/fmolb.2025.1519977,https://pubmed.ncbi.nlm.nih.gov/40144023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,42793167,Integrated Multi-Omic Analyses Reveal Gender-Specific Molecular Mechanisms Regulating Growth and Muscle Development in Zhongshan Partridge Ducks.,2026,10.3390/biom16091335,https://pubmed.ncbi.nlm.nih.gov/42793167/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,40593645,Molecular mechanism of Activin receptor inhibition by DLK1.,2025,10.1038/s41467-025-60634-3,https://pubmed.ncbi.nlm.nih.gov/40593645/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,41813653,Gli2 and Gli3 synergistically mediate HH-TGF-β crosstalk in mesenchymal progenitor cells to orchestrate tooth root morphogenesis.,2026,10.1038/s41368-026-00427-6,https://pubmed.ncbi.nlm.nih.gov/41813653/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,40045085,lncRNA ACVR2B-AS1 modulates thyroid cancer progression by regulating miR-195-5p.,2025,10.1007/s12672-025-01993-7,https://pubmed.ncbi.nlm.nih.gov/40045085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,42838888,"Temporal regulation of activin, follistatin, and growth differentiation factor 15 in the liver and circulation during high-fat diet-induced fatty liver disease.",2026,10.4196/kjpp.26.031,https://pubmed.ncbi.nlm.nih.gov/42838888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,40424086,Splicing of erythroid transcription factor is associated with therapeutic response in myelodysplastic syndromes.,2025,10.1172/jci189266,https://pubmed.ncbi.nlm.nih.gov/40424086/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,40435286,Circular RNA profiling reveals an abundant circPTK2 that contributes everolimus-induced endothelial cell dysfunction via regulating miR-1-5p/ACVR2B/StarD13 axis.,2025,10.1080/00015385.2025.2510706,https://pubmed.ncbi.nlm.nih.gov/40435286/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,41598250,Non-Coding RNA Biomarkers in Prostate Cancer: Evidence Mapping and In Silico Characterization.,2026,10.3390/life16010095,https://pubmed.ncbi.nlm.nih.gov/41598250/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,38500216,iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva.,2024,10.1186/s13287-024-03691-7,https://pubmed.ncbi.nlm.nih.gov/38500216/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,38450186,Humoral immunoprofiling identifies novel biomarkers and an immune suppressive autoantibody phenotype at the site of disease in pancreatic ductal adenocarcinoma.,2024,10.3389/fonc.2024.1330419,https://pubmed.ncbi.nlm.nih.gov/38450186/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,41352711,MEGF8-mediated GDF8 phosphorylation drives TGF-β hyperactivation in osteoarthritis cartilage degeneration: Mechanism and targeted intervention.,2026,10.1016/j.lfs.2025.124139,https://pubmed.ncbi.nlm.nih.gov/41352711/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,40416557,Combined rapamycin and mesenchymal stem/stromal cells derived from induced pluripotent stem cells-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva.,2025,10.1093/jbmrpl/ziaf068,https://pubmed.ncbi.nlm.nih.gov/40416557/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,41071262,Pancreatic Damage in Ovarian Cancer-Associated Cachexia Is Driven by Activin A Signalling.,2025,10.1002/jcsm.70096,https://pubmed.ncbi.nlm.nih.gov/41071262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,40355814,INHBA&lt;sup&gt;+&lt;/sup&gt; macrophages and Pro-inflammatory CAFs are associated with distinctive immunosuppressive tumor microenvironment in submucous Fibrosis-Derived oral squamous cell carcinoma.,2025,10.1186/s12885-025-14261-2,https://pubmed.ncbi.nlm.nih.gov/40355814/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,39533028,"ACVR2B polymorphism, Adiponectin, and GDF-15 levels as biomarkers for cachexia in gastrointestinal cancer.",2024,10.1038/s41598-024-79176-7,https://pubmed.ncbi.nlm.nih.gov/39533028/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,40312924,Gel Electrophoretic Detection of Black Market ACE-031.,2025,10.1002/dta.3898,https://pubmed.ncbi.nlm.nih.gov/40312924/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,41487000,Clinical Applications of Ligand Traps Targeting Activin Type II Receptors.,2026,10.2174/0118715230416604251029062751,https://pubmed.ncbi.nlm.nih.gov/41487000/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,40439841,Transcriptome-Wide Sequencing Identifies Non-Coding RNAs and Their Competing Endogenous RNA Networks During the Stages of pPGCLCs-Induced Differentiation.,2025,10.1007/s12015-025-10902-y,https://pubmed.ncbi.nlm.nih.gov/40439841/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,38491523,Machine learning-driven prognostic analysis of cuproptosis and disulfidptosis-related lncRNAs in clear cell renal cell carcinoma: a step towards precision oncology.,2024,10.1186/s40001-024-01763-1,https://pubmed.ncbi.nlm.nih.gov/38491523/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,36950748,Blockade of Activin Receptor IIB Protects Arthritis Pathogenesis by Non-Amplification of Activin A-ACVR2B-NOX4 Axis Pathway.,2023,10.1002/advs.202205161,https://pubmed.ncbi.nlm.nih.gov/36950748/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,38201581,ACVR1: A Novel Therapeutic Target to Treat Anemia in Myelofibrosis.,2023,10.3390/cancers16010154,https://pubmed.ncbi.nlm.nih.gov/38201581/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,36105051,Low expression of INHB co-receptor TGFBR3 in connection with metastasis and immune infiltration in lung adenocarcinoma.,2022,,https://pubmed.ncbi.nlm.nih.gov/36105051/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,36769292,A New Signature of Sarcoma Based on the Tumor Microenvironment Benefits Prognostic Prediction.,2023,10.3390/ijms24032961,https://pubmed.ncbi.nlm.nih.gov/36769292/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ACVR2B,ENSG00000114739,Unsafe,38538617,Multi-organ single-cell transcriptomics of immune cells uncovered organ-specific gene expression and functions.,2024,10.1038/s41597-024-03152-z,https://pubmed.ncbi.nlm.nih.gov/38538617/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD2,ENSG00000140955,Unsafe,36698249,ADAD2 functions in spermiogenesis and piRNA biogenesis in mice.,2023,10.1111/andr.13400,https://pubmed.ncbi.nlm.nih.gov/36698249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD2,ENSG00000140955,Unsafe,37325547,Biallelic mutations in RNA-binding protein ADAD2 cause spermiogenic failure and non-obstructive azoospermia in humans.,2023,10.1093/hropen/hoad022,https://pubmed.ncbi.nlm.nih.gov/37325547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD2,ENSG00000140955,Unsafe,37428816,"Two RNA binding proteins, ADAD2 and RNF17, interact to form a heterogeneous population of novel meiotic germ cell granules with developmentally dependent organelle association.",2023,10.1371/journal.pgen.1010519,https://pubmed.ncbi.nlm.nih.gov/37428816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD2,ENSG00000140955,Unsafe,36930220,ADAD2 interacts with RNF17 in P-bodies to repress the Ping-pong cycle in pachytene piRNA biogenesis.,2023,10.1083/jcb.202206067,https://pubmed.ncbi.nlm.nih.gov/36930220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD2,ENSG00000140955,Unsafe,38108510,Correction: ADAD2 regulates heterochromatin in meiotic and post-meiotic male germ cells via translation of MDC1.,2023,10.1242/jcs.261751,https://pubmed.ncbi.nlm.nih.gov/38108510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD2,ENSG00000140955,Unsafe,36708028,Population-based genetic analysis in infertile men reveals novel mutations of ADAD family members in patients with impaired spermatogenesis.,2023,10.1093/hmg/ddad012,https://pubmed.ncbi.nlm.nih.gov/36708028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD2,ENSG00000140955,Unsafe,35191498,ADAD2 regulates heterochromatin in meiotic and post-meiotic male germ cells via translation of MDC1.,2022,10.1242/jcs.259196,https://pubmed.ncbi.nlm.nih.gov/35191498/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD2,ENSG00000140955,Unsafe,32665638,"ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility.",2020,10.1038/s41598-020-67834-5,https://pubmed.ncbi.nlm.nih.gov/32665638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD2,ENSG00000140955,Unsafe,41074104,Saliva as a potential and non-invasive approach to identify upregulated genes associated with comorbidities of T1DM: a brief report.,2025,10.1186/s40001-025-03105-1,https://pubmed.ncbi.nlm.nih.gov/41074104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD2,ENSG00000140955,Unsafe,39267058,Whole exome sequencing analysis of 167 men with primary infertility.,2024,10.1186/s12920-024-02005-3,https://pubmed.ncbi.nlm.nih.gov/39267058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD2,ENSG00000140955,Unsafe,35946499,Expression of Concern: ADAD2 regulates heterochromatin in meiotic and post-meiotic male germ cells via translation of MDC1.,2022,10.1242/jcs.260435,https://pubmed.ncbi.nlm.nih.gov/35946499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD2,ENSG00000140955,Unsafe,38407877,Molecular subtype identification and prognosis stratification by a immunogenic cell death-related gene expression signature in colorectal cancer.,2024,10.1080/14737140.2024.2320187,https://pubmed.ncbi.nlm.nih.gov/38407877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD2,ENSG00000140955,Unsafe,32741963,Genetic dissection of spermatogenic arrest through exome analysis: clinical implications for the management of azoospermic men.,2020,10.1038/s41436-020-0907-1,https://pubmed.ncbi.nlm.nih.gov/32741963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD2,ENSG00000140955,Unsafe,31281472,Three Biomarkers Predict Gastric Cancer Patients' Susceptibility To Fluorouracil-based Chemotherapy.,2019,10.7150/jca.31120,https://pubmed.ncbi.nlm.nih.gov/31281472/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAD2,ENSG00000140955,Unsafe,26184879,Dynamic profiling of double-stranded RNA binding proteins.,2015,10.1093/nar/gkv726,https://pubmed.ncbi.nlm.nih.gov/26184879/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,42902290,ADAM12 in a stromal-checkpoint framework: integrating tumor microenvironment remodeling and therapy resistance in solid tumors.,2026,10.1186/s12964-026-03103-8,https://pubmed.ncbi.nlm.nih.gov/42902290/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,41976350,The Potential of A Disintegrin and Metalloproteinase (ADAM) Proteins as Clinically Relevant Biomarkers in Colorectal Cancer: A Comprehensive Analysis.,2026,10.3390/cancers18071127,https://pubmed.ncbi.nlm.nih.gov/41976350/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,41881952,Glycolytic reprogramming mediated by the ADAM12/IGF1 axis promotes ossification of the posterior longitudinal ligament.,2026,10.1038/s41420-026-03044-8,https://pubmed.ncbi.nlm.nih.gov/41881952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,42025429,Involvement of ADAM12 in TGF-β1-Induced Proliferation of Rheumatoid Arthritis Synovial Fibroblasts.,2026,10.18926/amo/70450,https://pubmed.ncbi.nlm.nih.gov/42025429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,42705211,Integrated single-cell and bulk transcriptomic analysis reveals an epithelial cell-derived prognostic and immunotherapeutic signature with ADAM12 as a key functional regulator in non-small cell lung cancer.,2026,10.1016/j.tranon.2026.103028,https://pubmed.ncbi.nlm.nih.gov/42705211/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,42363282,miR-2116-5p functions as a tumor suppressor in lung adenocarcinoma by targeting ADAM12 and serves as a prognostic biomarker.,2026,10.1186/s13019-026-04473-3,https://pubmed.ncbi.nlm.nih.gov/42363282/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,42864774,Integrated scRNA-Seq and Spatial Transcriptomics Reveal CHPF and GPC1 as Markers of Cancer-Associated Fibroblast-Dominant Domains in Colorectal Cancer.,2026,10.1002/cam4.72369,https://pubmed.ncbi.nlm.nih.gov/42864774/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,42653443,"Expression of &lt;i&gt;ADAM10&lt;/i&gt;, &lt;i&gt;12&lt;/i&gt;, &lt;i&gt;17&lt;/i&gt;, and &lt;i&gt;28&lt;/i&gt; Genes in Colorectal Cancer.",2026,10.3390/ijms27167441,https://pubmed.ncbi.nlm.nih.gov/42653443/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,42117088,ADAM12 Stabilizes EIF3B to Promote Glycolysis and Tumor Progression in Hepatocellular Carcinoma.,2026,10.2147/jhc.s560478,https://pubmed.ncbi.nlm.nih.gov/42117088/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,41800239,BMP2-induced Adam12&lt;sup&gt;+&lt;/sup&gt; Fibroblasts Dictate Wound-associated Skin Scarring and Fibrosis.,2026,10.7150/ijbs.123725,https://pubmed.ncbi.nlm.nih.gov/41800239/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,41972134,The molecular mechanism of circRNA_0021727 in inflammation of eosinophilic chronic rhinosinusitis.,2026,10.3389/fimmu.2026.1737875,https://pubmed.ncbi.nlm.nih.gov/41972134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,42886280,ITF2357 exerts anti‑tumor activity in colorectal cancer via the miR‑1938/ADAM12 axis.,2026,10.1007/s11033-026-12944-y,https://pubmed.ncbi.nlm.nih.gov/42886280/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,41281927,Contributions of ADAM12 via HB-EGF/EGFR signaling cascades to EMT and cancer progression in pancreas.,2026,10.3892/mco.2025.2914,https://pubmed.ncbi.nlm.nih.gov/41281927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,41501303,Functional ADAM12 variants modulate proteolytic activity and influence metabolic traits.,2026,10.1038/s41598-025-34827-1,https://pubmed.ncbi.nlm.nih.gov/41501303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,42540716,"A multi-dataset single-cell meta-analysis of human keloid skin across Asian, Black and White populations reveals endothelial and mesenchymal programs linked to ethnic disparities.",2026,10.3389/fmed.2026.1751725,https://pubmed.ncbi.nlm.nih.gov/42540716/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,41171558,Unveiling the significance of ADAM12 through pan-cancer analysis and experimental verification in gastric cancer.,2025,10.1007/s12672-025-03837-w,https://pubmed.ncbi.nlm.nih.gov/41171558/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,42733814,"Integrative transcriptomics and human tibial artery validation identify &lt;i&gt;ADAM12&lt;/i&gt;, &lt;i&gt;PDK4&lt;/i&gt;, and &lt;i&gt;RUNX1&lt;/i&gt; as peripheral artery disease-associated genes enriched in calcified tibial arteries.",2026,10.1016/j.jvssci.2026.100434,https://pubmed.ncbi.nlm.nih.gov/42733814/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,42414644,"Distinct Molecular Signature of Earlobe Keloids: Integrated Transcriptomic Analysis of Extracellualr Matrix, Metalloproteinase, and Metabolic Pathways.",2026,10.1007/s00266-026-06136-z,https://pubmed.ncbi.nlm.nih.gov/42414644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,42020364,Identification and molecular typing of disulfidptosis-related biomarkers in anaplastic thyroid carcinoma.,2026,10.1038/s41420-026-03089-9,https://pubmed.ncbi.nlm.nih.gov/42020364/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,40982030,MicroRNA-29b targets ADAM12 and 19 to regulate the extracellular matrix in lamina cribrosa cells.,2025,10.1007/s00441-025-04006-9,https://pubmed.ncbi.nlm.nih.gov/40982030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,41544628,Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity.,2026,10.1016/j.ccell.2025.12.018,https://pubmed.ncbi.nlm.nih.gov/41544628/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,39478152,Fibrolytic vaccination against ADAM12 reduces desmoplasia in preclinical pancreatic adenocarcinomas.,2024,10.1038/s44321-024-00157-4,https://pubmed.ncbi.nlm.nih.gov/39478152/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,39984619,Pan-cancer analysis identifies ADAM12 as a prognostic biomarker and indicator of immune infiltration in glioma.,2025,10.1038/s41598-025-90121-0,https://pubmed.ncbi.nlm.nih.gov/39984619/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,42103736,Cross-species insights into placental evolution and diseases at the single-cell resolution.,2026,10.1038/s41467-026-72652-w,https://pubmed.ncbi.nlm.nih.gov/42103736/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,40642061,Revealing the significance of tissue-resident memory T cells in lung adenocarcinoma through bioinformatic analysis and experimental validation.,2025,10.3389/fimmu.2025.1600863,https://pubmed.ncbi.nlm.nih.gov/40642061/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,39235446,Serum cytokine profiles in children with IgA vasculitis with nephritis.,2025,10.17305/bb.2024.11081,https://pubmed.ncbi.nlm.nih.gov/39235446/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,41478761,"Altered AP-1, RUNX, and EGR chromatin dynamics drive human fibrotic lung disease.",2026,10.1016/j.ard.2025.12.003,https://pubmed.ncbi.nlm.nih.gov/41478761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,40427200,"ADAM Proteases in Cancer: Biological Roles, Therapeutic Challenges, and Emerging Opportunities.",2025,10.3390/cancers17101703,https://pubmed.ncbi.nlm.nih.gov/40427200/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,39097147,Circadian clock component PER2 negatively regulates CD4+ T cell IFN-γ production in ulcerative colitis.,2024,10.1016/j.mucimm.2024.07.010,https://pubmed.ncbi.nlm.nih.gov/39097147/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM12,ENSG00000148848,Unsafe,40728965,The Construction of ceRNA Regulatory Network Unraveled Prognostic Biomarkers and Repositioned Drug Candidates for the Management of Pancreatic Ductal Adenocarcinoma.,2025,10.3390/cimb47070496,https://pubmed.ncbi.nlm.nih.gov/40728965/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM20,ENSG00000134007,Unsafe,42454366,ADAM20 Participates Modestly to Fertilization as Its Absence Leads to In Vitro Hypofertility in Mouse.,2026,10.1002/cbf.70265,https://pubmed.ncbi.nlm.nih.gov/42454366/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM20,ENSG00000134007,Unsafe,39177846,Epigenetic and genetic risk of Alzheimer disease from autopsied brains in two ethnic groups.,2024,10.1007/s00401-024-02778-y,https://pubmed.ncbi.nlm.nih.gov/39177846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM20,ENSG00000134007,Unsafe,38835510,Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility.,2024,10.3389/fcell.2024.1411162,https://pubmed.ncbi.nlm.nih.gov/38835510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM20,ENSG00000134007,Unsafe,29416755,Sperm-egg fusion disorder in a Chinese male patient was associated with a rare ADAM20 variant.,2018,10.18632/oncotarget.23331,https://pubmed.ncbi.nlm.nih.gov/29416755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM20,ENSG00000134007,Unsafe,35805966,miR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium.,2022,10.3390/ijms23136962,https://pubmed.ncbi.nlm.nih.gov/35805966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM20,ENSG00000134007,Unsafe,35574354,Integrated Whole-Transcriptome Profiling and Bioinformatics Analysis of the Polypharmacological Effects of Ganoderic Acid Me in Colorectal Cancer Treatment.,2022,10.3389/fonc.2022.833375,https://pubmed.ncbi.nlm.nih.gov/35574354/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM20,ENSG00000134007,Unsafe,39118059,Genetic diversity and signatures of selection in Icelandic horses and Exmoor ponies.,2024,10.1186/s12864-024-10682-8,https://pubmed.ncbi.nlm.nih.gov/39118059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM20,ENSG00000134007,Unsafe,36036911,Decreased Levels of DNA Methylation in the PCDHA Gene Cluster as a Risk Factor for Early-Onset High Myopia in Young Children.,2022,10.1167/iovs.63.9.31,https://pubmed.ncbi.nlm.nih.gov/36036911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM20,ENSG00000134007,Unsafe,30909692,Relation between Tetraspanin- Associated and Tetraspanin- Non- Associated Exosomal Proteases and Metabolic Syndrome in Colorectal Cancer Patients,2019,10.31557/apjcp.2019.20.3.809,https://pubmed.ncbi.nlm.nih.gov/30909692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM20,ENSG00000134007,Unsafe,34177493,Genome-Wide Association Study of Motor Coordination.,2021,10.3389/fnhum.2021.669902,https://pubmed.ncbi.nlm.nih.gov/34177493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM20,ENSG00000134007,Unsafe,29426285,Transcriptome profiles in peripheral white blood cells at the time of artificial insemination discriminate beef heifers with different fertility potential.,2018,10.1186/s12864-018-4505-4,https://pubmed.ncbi.nlm.nih.gov/29426285/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM20,ENSG00000134007,Unsafe,32363588,Genetic dissection of reproductive performance of dairy cows under heat stress.,2020,10.1111/age.12943,https://pubmed.ncbi.nlm.nih.gov/32363588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM20,ENSG00000134007,Unsafe,10524237,The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries.,1999,10.1016/s0378-1119(99)00302-9,https://pubmed.ncbi.nlm.nih.gov/10524237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM32,ENSG00000197140,Unsafe,42652060,Exploratory Genome and Transcriptome-Wide Association Analyses of Addiction-Related Phenotypes in a Twin Cohort.,2026,10.3390/biomedicines14081677,https://pubmed.ncbi.nlm.nih.gov/42652060/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM32,ENSG00000197140,Unsafe,40507253,ADAM32 Oncogene in Hepatoblastoma Is Regulated by IGF2BP2.,2025,10.3390/cancers17111772,https://pubmed.ncbi.nlm.nih.gov/40507253/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM32,ENSG00000197140,Unsafe,40893713,"Expression, Localization, and Processing of Chicken Sperm ADAM32L2 during the Acrosome Reaction: A Possible Function in the Sperm-Egg Interaction.",2025,10.2141/jpsa.2025024,https://pubmed.ncbi.nlm.nih.gov/40893713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM32,ENSG00000197140,Unsafe,41042295,scRNA-seq deciphers molecular mechanisms of endocrine disruptor 4-nonylphenol impairing spermatogenesis in mice.,2025,10.1007/s10565-025-10095-7,https://pubmed.ncbi.nlm.nih.gov/41042295/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM32,ENSG00000197140,Unsafe,36230656,Oncogenic Role of ADAM32 in Hepatoblastoma: A Potential Molecular Target for Therapy.,2022,10.3390/cancers14194732,https://pubmed.ncbi.nlm.nih.gov/36230656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM32,ENSG00000197140,Unsafe,40276155,Proteomic analysis of Toraya buffalo seminal plasma and sperm: uncovering insights to optimize reproductive success.,2025,10.3389/fvets.2025.1492135,https://pubmed.ncbi.nlm.nih.gov/40276155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM32,ENSG00000197140,Unsafe,32972883,Normal fertility in male mice lacking ADAM32 with testis-specific expression.,2020,10.1016/j.repbio.2020.09.001,https://pubmed.ncbi.nlm.nih.gov/32972883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM32,ENSG00000197140,Unsafe,36619823,RNA-sequencing attest increased sperm motility in bovine spermatozoa treated with ethanolic extract of Putranjiva roxburghii.,2023,10.1007/s13205-022-03452-4,https://pubmed.ncbi.nlm.nih.gov/36619823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM32,ENSG00000197140,Unsafe,35821031,Whole-genome sequence analysis reveals selection signatures for important economic traits in Xiang pigs.,2022,10.1038/s41598-022-14686-w,https://pubmed.ncbi.nlm.nih.gov/35821031/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM32,ENSG00000197140,Unsafe,27391163,Comprehensive Analysis of Genome Rearrangements in Eight Human Malignant Tumor Tissues.,2016,10.1371/journal.pone.0158995,https://pubmed.ncbi.nlm.nih.gov/27391163/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM32,ENSG00000197140,Unsafe,30464627,A novel 12-marker panel of cancer-associated fibroblasts involved in progression of hepatocellular carcinoma.,2018,10.2147/cmar.s176152,https://pubmed.ncbi.nlm.nih.gov/30464627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM32,ENSG00000197140,Unsafe,30005627,Chromoanasynthesis is a common mechanism that leads to ERBB2 amplifications in a cohort of early stage HER2+ breast cancer samples.,2018,10.1186/s12885-018-4594-0,https://pubmed.ncbi.nlm.nih.gov/30005627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM32,ENSG00000197140,Unsafe,29126140,Zona pellucida-binding protein 2 (ZPBP2) and several proteins containing BX7B motifs in human sperm may have hyaluronic acid binding or recognition properties.,2017,10.1093/molehr/gax053,https://pubmed.ncbi.nlm.nih.gov/29126140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM32,ENSG00000197140,Unsafe,23923051,Transcriptome analysis of duck liver and identification of differentially expressed transcripts in response to duck hepatitis A virus genotype C infection.,2013,10.1371/journal.pone.0071051,https://pubmed.ncbi.nlm.nih.gov/23923051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM32,ENSG00000197140,Unsafe,12568724,Identification and characterization of ADAM32 with testis-predominant gene expression.,2003,10.1016/s0378-1119(02)01202-7,https://pubmed.ncbi.nlm.nih.gov/12568724/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAM32,ENSG00000197140,Unsafe,16407499,Expression and relationship of male reproductive ADAMs in mouse.,2006,10.1095/biolreprod.105.048892,https://pubmed.ncbi.nlm.nih.gov/16407499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,42754167,Identification of 2 Novel Compound Heterozygous ADAMTS17 Variants Associated With Weill-Marchesani Syndrome 4.,2026,10.1016/j.labinv.2026.106165,https://pubmed.ncbi.nlm.nih.gov/42754167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,41034152,Combined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and skin phenotypes.,2025,10.26508/lsa.202503232,https://pubmed.ncbi.nlm.nih.gov/41034152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,42064014,Genome-Wide Meta-Analysis for High Myopia Provides Insights into Disease Mechanisms and Reveals a Causal Link to Primary Open-Angle Glaucoma.,2026,10.1016/j.xops.2026.101165,https://pubmed.ncbi.nlm.nih.gov/42064014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,41572998,A novel compound heterozygous mutation in &lt;i&gt;ADAMTS17&lt;/i&gt; identified in a Chinese family with Weill-Marchesani syndrome.,2026,10.18240/ijo.2026.02.04,https://pubmed.ncbi.nlm.nih.gov/41572998/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,42151490,Acromelic dysplasias: similarities and differences in clinical and molecular findings in 12 Turkish patients.,2026,10.1007/s00431-026-07075-2,https://pubmed.ncbi.nlm.nih.gov/42151490/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,42083632,Integrative genomic and functional characterization of ADAMTS3 reveals its inflammatory regulation via NF-κB and STAT3 pathways in osteosarcoma.,2026,10.1002/ccs3.70072,https://pubmed.ncbi.nlm.nih.gov/42083632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,41915433,&lt;i&gt;ADAMTS&lt;/i&gt; and &lt;i&gt;ADAMTSL&lt;/i&gt; Mutations in Connective Tissue Disorders.,2026,10.1152/physiol.00043.2025,https://pubmed.ncbi.nlm.nih.gov/41915433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,42413148,Depressive symptoms in mid-pregnancy are associated with DNA methylation marks in the placenta.,2026,10.1016/j.placenta.2026.06.020,https://pubmed.ncbi.nlm.nih.gov/42413148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,41518141,Genome-wide meta-analysis identifies genetic risk loci for mono- and polyneuropathies in 983 477 individuals.,2026,10.1093/hmg/ddaf200,https://pubmed.ncbi.nlm.nih.gov/41518141/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,41136527,A de novo FBN1 variant likely causes congenital bilateral ectopia lentis in a crossbred horse.,2025,10.1038/s41598-025-21139-7,https://pubmed.ncbi.nlm.nih.gov/41136527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,41561974,Genomic and ancestral variations linked to the development of post-acute sequelae of SARS-CoV-2 infection in Indian populations.,2025,10.3389/fgene.2025.1696764,https://pubmed.ncbi.nlm.nih.gov/41561974/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,41639873,A novel homozygous ADAMTS10 frameshift variant in Weill-Marchesani syndrome in a Chinese family.,2026,10.1186/s12920-026-02308-7,https://pubmed.ncbi.nlm.nih.gov/41639873/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,39575453,Key Proteins for Regeneration in A. mexicanum: Transcriptomic Insights From Aged and Juvenile Limbs.,2024,10.1155/2024/5460694,https://pubmed.ncbi.nlm.nih.gov/39575453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,36966180,A common variant rs2054564 in ADAMST17 is associated with susceptibility to lumbar spondylosis.,2023,10.1038/s41598-023-32155-w,https://pubmed.ncbi.nlm.nih.gov/36966180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,40132314,Exploring the functional variations of key candidate genes affecting egg production by hypothalamic-pituitary-ovarian axis in chickens.,2025,10.1016/j.psj.2025.105027,https://pubmed.ncbi.nlm.nih.gov/40132314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,37443653,Contribution of Dynamic and Genetic Tests for Short Stature Diagnosing: A Case Report.,2023,10.3390/diagnostics13132259,https://pubmed.ncbi.nlm.nih.gov/37443653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,37206179,Novel homozygous ADAMTS17 missense variant in Weill-Marchesani syndrome.,2023,10.18240/ijo.2023.05.04,https://pubmed.ncbi.nlm.nih.gov/37206179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,37481583,Screening of hub inflammatory bowel disease biomarkers and identification of immune-related functions based on basement membrane genes.,2023,10.1186/s40001-023-01193-5,https://pubmed.ncbi.nlm.nih.gov/37481583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,40144770,Isolated Spherophakia and Phacodonesis in a Young Child With Short Stature: A Case Report.,2025,10.7759/cureus.81223,https://pubmed.ncbi.nlm.nih.gov/40144770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,36810712,The role of ADAMTS6 and ADAMTS17 polymorphisms in susceptibility to lumbar disc herniation in Chinese Han population.,2023,10.1007/s00586-023-07586-8,https://pubmed.ncbi.nlm.nih.gov/36810712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,40025527,Genetic landscape and ocular biometric correlations in microspherophakia: insights from a comprehensive patient cohort.,2025,10.1186/s40246-025-00729-6,https://pubmed.ncbi.nlm.nih.gov/40025527/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,38982354,Identification of consensus homozygous regions and their associations with growth and feed efficiency traits in American mink.,2024,10.1186/s12863-024-01252-8,https://pubmed.ncbi.nlm.nih.gov/38982354/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,36712882,Genome-wide DNA methylation profiling in chronic lymphocytic leukaemia.,2022,10.3389/fgene.2022.1056043,https://pubmed.ncbi.nlm.nih.gov/36712882/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,34057920,"Weill-Marchesani Syndrome, a Rare Presentation of Severe Short Stature with Review of the Literature.",2021,10.12659/ajcr.930824,https://pubmed.ncbi.nlm.nih.gov/34057920/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,29885460,ADAMTS proteins in human disorders.,2018,10.1016/j.matbio.2018.06.002,https://pubmed.ncbi.nlm.nih.gov/29885460/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,30833571,A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome.,2019,10.1038/s41467-019-08993-6,https://pubmed.ncbi.nlm.nih.gov/30833571/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,31807642,Identification of genomic regions and candidate genes of functional importance for gastrointestinal parasite resistance traits in Djallonké sheep of Burkina Faso.,2019,10.5194/aab-62-313-2019,https://pubmed.ncbi.nlm.nih.gov/31807642/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS17,ENSG00000140470,Unsafe,19836009,"Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature.",2009,10.1016/j.ajhg.2009.09.011,https://pubmed.ncbi.nlm.nih.gov/19836009/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,42612406,Comparative transcriptome analysis provides insights into dorso-ventral color pattern formation of Holothuria edulis.,2026,10.1016/j.cbd.2026.101979,https://pubmed.ncbi.nlm.nih.gov/42612406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,38459095,"Doppler ultrasonographic scan, gene expression and serum profile of immune, APPs and antioxidant markers in Egyptian buffalo-cows with clinical endometritis.",2024,10.1038/s41598-024-56258-0,https://pubmed.ncbi.nlm.nih.gov/38459095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,36322137,Novel role for conceptus signals in mRNA expression regulation by DNA methylation in porcine endometrium during early pregnancy†.,2023,10.1093/biolre/ioac193,https://pubmed.ncbi.nlm.nih.gov/36322137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,40837069,Genome-Wide Association Study and Rare Variant Association Studies of Strabismus in the &lt;i&gt;All of Us&lt;/i&gt; Research Program.,2025,10.1016/j.xops.2025.100873,https://pubmed.ncbi.nlm.nih.gov/40837069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,37169079,Degradomic Identification of Membrane Type 1-Matrix Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate.,2023,10.1016/j.mcpro.2023.100566,https://pubmed.ncbi.nlm.nih.gov/37169079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,34195596,A new mouse mutant with cleavage-resistant versican and isoform-specific versican mutants demonstrate that proteolysis at the Glu441-Ala442 peptide bond in the V1 isoform is essential for interdigital web regression.,2021,10.1016/j.mbplus.2021.100064,https://pubmed.ncbi.nlm.nih.gov/34195596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,37685013,Cleft Lip and Palate in Four Full-Sib Puppies from a Single Litter of Staffordshire Bull Terrier Dogs: An Anatomical and Genetic Study.,2023,10.3390/ani13172749,https://pubmed.ncbi.nlm.nih.gov/37685013/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,33909046,Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ.,2021,10.1093/glycob/cwab033,https://pubmed.ncbi.nlm.nih.gov/33909046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,36619972,Identifying biomarkers of differential chemotherapy response in TNBC patient-derived xenografts with a CTD/WGCNA approach.,2023,10.1016/j.isci.2022.105799,https://pubmed.ncbi.nlm.nih.gov/36619972/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,39048931,Genomic analysis reveals the association of KIT and MITF variants with the white spotting in swamp buffaloes.,2024,10.1186/s12864-024-10634-2,https://pubmed.ncbi.nlm.nih.gov/39048931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,38755266,Prediction models of persistent taxane-induced peripheral neuropathy among breast cancer survivors using whole-exome sequencing.,2024,10.1038/s41698-024-00594-x,https://pubmed.ncbi.nlm.nih.gov/38755266/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,35205249,Whole Genome Sequencing Unravels New Genetic Determinants of Early-Onset Familial Osteoporosis and Low BMD in Malta.,2022,10.3390/genes13020204,https://pubmed.ncbi.nlm.nih.gov/35205249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,31600785,ADAMTS9 and ADAMTS20 are differentially affected by loss of B3GLCT in mouse model of Peters plus syndrome.,2019,10.1093/hmg/ddz225,https://pubmed.ncbi.nlm.nih.gov/31600785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,30814516,Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis.,2019,10.1038/s41467-019-08520-7,https://pubmed.ncbi.nlm.nih.gov/30814516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,36844630,Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas.,2023,10.3892/ol.2023.13707,https://pubmed.ncbi.nlm.nih.gov/36844630/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,29860265,"Relationship Between ADAMTS8, ADAMTS18, and ADAMTS20 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) Expressions and Tumor Molecular Classification, Clinical Pathological Parameters, and Prognosis in Breast Invasive Ductal Carcinoma.",2018,10.12659/msm.907310,https://pubmed.ncbi.nlm.nih.gov/29860265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,35402275,Genetic Characteristics Associated With Drug Resistance in Lung Cancer and Colorectal Cancer Using Whole Exome Sequencing of Cell-Free DNA.,2022,10.3389/fonc.2022.843561,https://pubmed.ncbi.nlm.nih.gov/35402275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,25798845,Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate.,2015,10.1371/journal.pgen.1005059,https://pubmed.ncbi.nlm.nih.gov/25798845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,32337892,"Review of Potential Significance of Mutations of ADAMTS20, NF1 and PKHD1 Detected Using Next Generation Sequencing (NGS) in Dermal Fibrosarcoma Arising in Dermatofibrosarcoma Protuberans.",2020,10.3897/folmed.62.e48003,https://pubmed.ncbi.nlm.nih.gov/32337892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,36302822,Tracking footprints of artificial and natural selection signatures in breeding and non-breeding cats.,2022,10.1038/s41598-022-22155-7,https://pubmed.ncbi.nlm.nih.gov/36302822/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,33395752,"Biomarkers of response to ibrutinib plus nivolumab in relapsed diffuse large B-cell lymphoma, follicular lymphoma, or Richter's transformation.",2021,10.1016/j.tranon.2020.100977,https://pubmed.ncbi.nlm.nih.gov/33395752/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,32560248,Genomic Structural Diversity in Local Goats: Analysis of Copy-Number Variations.,2020,10.3390/ani10061040,https://pubmed.ncbi.nlm.nih.gov/32560248/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,29885460,ADAMTS proteins in human disorders.,2018,10.1016/j.matbio.2018.06.002,https://pubmed.ncbi.nlm.nih.gov/29885460/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,32328350,Transcriptome for the breast muscle of Jinghai yellow chicken at early growth stages.,2020,10.7717/peerj.8950,https://pubmed.ncbi.nlm.nih.gov/32328350/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,32636717,The plasma peptides of sepsis.,2020,10.1186/s12014-020-09288-5,https://pubmed.ncbi.nlm.nih.gov/32636717/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS20,ENSG00000173157,Unsafe,21347333,Transcriptional profiling of peripheral blood mononuclear cells in pancreatic cancer patients identifies novel genes with potential diagnostic utility.,2011,10.1371/journal.pone.0017014,https://pubmed.ncbi.nlm.nih.gov/21347333/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,42829835,"Loss of function variants in ADAMTS6: a new connective tissue disorder with heart defect, aortic aneurysm and neurodevelopmental features.",2026,10.1016/j.gim.2026.102741,https://pubmed.ncbi.nlm.nih.gov/42829835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,41465277,Deciphering the Role of ADAMTS6 in the Epithelial-Mesenchymal Transition of Lung Adenocarcinoma Cells.,2025,10.3390/ijms262411850,https://pubmed.ncbi.nlm.nih.gov/41465277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,41399538,Generation of a conditional &lt;i&gt;Adamts6&lt;/i&gt; mouse allele reveals roles in lung maturation in addition to cardiac and musculoskeletal development.,2025,10.1016/j.mbplus.2025.100186,https://pubmed.ncbi.nlm.nih.gov/41399538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,41144105,ADAMTS6 Promotes Angiogenesis and Tumor Growth in Gastric Carcinoma.,2026,10.1007/s10528-025-11259-0,https://pubmed.ncbi.nlm.nih.gov/41144105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,39940703,Assessment of Methylation in Selected &lt;i&gt;ADAMTS&lt;/i&gt; Family Genes in Non-Small-Cell Lung Cancer.,2025,10.3390/ijms26030934,https://pubmed.ncbi.nlm.nih.gov/39940703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,41915433,&lt;i&gt;ADAMTS&lt;/i&gt; and &lt;i&gt;ADAMTSL&lt;/i&gt; Mutations in Connective Tissue Disorders.,2026,10.1152/physiol.00043.2025,https://pubmed.ncbi.nlm.nih.gov/41915433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,38339175,"ADAMTS Gene-Derived circRNA Molecules in Non-Small-Cell Lung Cancer: Expression Profiling, Clinical Correlations and Survival Analysis.",2024,10.3390/ijms25031897,https://pubmed.ncbi.nlm.nih.gov/38339175/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,41179154,Perfluoroundecanoic Acid Inhibits Liver Cell Development in Pubertal Male Rats via Inducing Oxidative Stress.,2025,10.1021/acsomega.5c07073,https://pubmed.ncbi.nlm.nih.gov/41179154/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,36700045,Exosomal circ-PTPN22 and circ-ADAMTS6 mark T cell exhaustion and neutrophil extracellular traps in Asian intrahepatic cholangiocarcinoma.,2023,10.1016/j.omtn.2022.12.012,https://pubmed.ncbi.nlm.nih.gov/36700045/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,36339722,"ADAMTS6: Emerging roles in cardiovascular, musculoskeletal and cancer biology.",2022,10.3389/fmolb.2022.1023511,https://pubmed.ncbi.nlm.nih.gov/36339722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,35503090,Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.,2022,10.7554/elife.71142,https://pubmed.ncbi.nlm.nih.gov/35503090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,38939621,Gene expression profiling and the isocitrate dehydrogenase mutational landscape of temozolomide‑resistant glioblastoma.,2024,10.3892/ol.2024.14511,https://pubmed.ncbi.nlm.nih.gov/38939621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,39491682,Deciphering the genetic underpinnings of neuroticism: A Mendelian randomization study of druggable gene targets.,2025,10.1016/j.jad.2024.11.002,https://pubmed.ncbi.nlm.nih.gov/39491682/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,36267748,Molecular mechanism of CD163+ tumor-associated macrophage (TAM)-derived exosome-induced cisplatin resistance in ovarian cancer ascites.,2022,10.21037/atm-22-4267,https://pubmed.ncbi.nlm.nih.gov/36267748/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,38342263,Whole-transcriptome analysis of longissimus dorsi muscle in cattle-yaks reveals the regulatory functions of ADAMTS6 gene in myoblasts.,2024,10.1016/j.ijbiomac.2024.129985,https://pubmed.ncbi.nlm.nih.gov/38342263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,36368447,ADAMTS6 cleaves the large latent TGFβ complex and increases the mechanotension of cells to activate TGFβ.,2022,10.1016/j.matbio.2022.11.001,https://pubmed.ncbi.nlm.nih.gov/36368447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,36810712,The role of ADAMTS6 and ADAMTS17 polymorphisms in susceptibility to lumbar disc herniation in Chinese Han population.,2023,10.1007/s00586-023-07586-8,https://pubmed.ncbi.nlm.nih.gov/36810712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,40751879,Identification of colorectal cancer molecular subtypes and prognostic features based on basement membrane-related genes.,2026,10.1007/s13353-025-00992-2,https://pubmed.ncbi.nlm.nih.gov/40751879/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,33851708,Identified a disintegrin and metalloproteinase with thrombospondin motifs 6 serve as a novel gastric cancer prognostic biomarker by bioinformatics analysis.,2021,10.1042/bsr20204359,https://pubmed.ncbi.nlm.nih.gov/33851708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,33063817,A metalloproteinase of the disintegrin and metalloproteinases and the ThromboSpondin Motifs 6 as a novel marker for colon cancer: functional experiments.,2020,10.1590/1678-4685-gmb-2019-0266,https://pubmed.ncbi.nlm.nih.gov/33063817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,37529607,Therapeutic response to pazopanib: case report and literature review on molecular abnormalities of aggressive prolactinomas.,2023,10.3389/fendo.2023.1195792,https://pubmed.ncbi.nlm.nih.gov/37529607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,30012220,"Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.",2018,10.1186/s13059-018-1457-6,https://pubmed.ncbi.nlm.nih.gov/30012220/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,34389782,Deep learning-based gene selection in comprehensive gene analysis in pancreatic cancer.,2021,10.1038/s41598-021-95969-6,https://pubmed.ncbi.nlm.nih.gov/34389782/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,33352066,ADAMTS proteases in cardiovascular physiology and disease.,2020,10.1098/rsob.200333,https://pubmed.ncbi.nlm.nih.gov/33352066/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,31409848,Transcriptomic Profiling of Adipose Derived Stem Cells Undergoing Osteogenesis by RNA-Seq.,2019,10.1038/s41598-019-48089-1,https://pubmed.ncbi.nlm.nih.gov/31409848/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,25302706,Transcriptome analysis reveals the contribution of thermal and the specific effects in cellular response to millimeter wave exposure.,2014,10.1371/journal.pone.0109435,https://pubmed.ncbi.nlm.nih.gov/25302706/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADAMTS6,ENSG00000049192,Unsafe,22185580,Identification of proprotein convertase substrates using genome-wide expression correlation analysis.,2011,10.1186/1471-2164-12-618,https://pubmed.ncbi.nlm.nih.gov/22185580/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,42596553,Adenylyl Cyclase (ADCY) Protein Family: Molecular Mechanisms and Therapeutic Potential in Glucose and Lipid Metabolism and Feeding Regulation.,2026,10.1002/jcp.70216,https://pubmed.ncbi.nlm.nih.gov/42596553/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,41843491,Targeting Soluble Adenylyl Cyclase for On-Demand Contraception.,2026,10.1152/physiol.00009.2026,https://pubmed.ncbi.nlm.nih.gov/41843491/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,41197733,Biochemical characterization of the full-length isoform of soluble adenylyl cyclase.,2025,10.1016/j.jbc.2025.110889,https://pubmed.ncbi.nlm.nih.gov/41197733/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,42617826,Salidroside and tyrosol exert anxiolytic effects by modulating brain endogenous phenols via 4-hydroxyphenyllactic acid as a key functional metabolite.,2027,10.1016/j.jep.2026.122303,https://pubmed.ncbi.nlm.nih.gov/42617826/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,40486851,Obesity-driven oleoylcarnitine accumulation in tumor microenvironment promotes breast cancer metastasis-like phenotype.,2025,10.1016/j.apsb.2025.02.026,https://pubmed.ncbi.nlm.nih.gov/40486851/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,39949963,Adenylate cyclase 10 promotes brown adipose tissue thermogenesis.,2025,10.1016/j.isci.2025.111833,https://pubmed.ncbi.nlm.nih.gov/39949963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,42308645,Differential expression patterns of selective energy metabolism associated genes in fresh and freeze-thawed bubaline spermatozoa at uniform durations of in vitro capacitation.,2026,10.1016/j.cryobiol.2026.105670,https://pubmed.ncbi.nlm.nih.gov/42308645/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,42034941,Coronavirus nucleocapsid proteins hijack host protein kinase A catalytic subunit α into nucleus to evade from STAT1 signaling.,2026,10.1016/j.ijbiomac.2026.152211,https://pubmed.ncbi.nlm.nih.gov/42034941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,42768974,Genotype-Phenotype-Environment Associations and Potential Local Adaptation Signals in the Mesquite Lizard Along the Eastern Trans-Mexican Volcanic Belt.,2026,10.1111/mec.70561,https://pubmed.ncbi.nlm.nih.gov/42768974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,42241232,Assessing efficacy of ADCY10 inhibitors in cervical mucus.,2026,10.1093/molehr/gaag035,https://pubmed.ncbi.nlm.nih.gov/42241232/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,40003956,Cyclic AMP Rescue of Motility in Sperm Devoid of Soluble Adenylyl Cyclase.,2025,10.3390/ijms26041489,https://pubmed.ncbi.nlm.nih.gov/40003956/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,39891992,Novel biallelic ADCY10 variants cause asthenozoospermia with excessive residual cytoplasm and hydronephrosis in humans.,2025,10.1016/j.rbmo.2024.104481,https://pubmed.ncbi.nlm.nih.gov/39891992/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,39542189,Jinwu Jiangu Capsule alleviates rheumatoid arthritis symptoms by regulating the ADCY10 and cAMP/RANKL pathways.,2025,10.1016/j.jep.2024.119099,https://pubmed.ncbi.nlm.nih.gov/39542189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,40725190,Ethnic-Specific and UV-Independent Mutational Signatures of Basal Cell Carcinoma in Koreans.,2025,10.3390/ijms26146941,https://pubmed.ncbi.nlm.nih.gov/40725190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,36091839,Strategies to safely target widely expressed soluble adenylyl cyclase for contraception.,2022,10.3389/fphar.2022.953903,https://pubmed.ncbi.nlm.nih.gov/36091839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,41086178,β-Nicotinamide adenine dinucleotide (β-NAD) acts as a bronchodilator.,2025,10.1371/journal.pone.0334491,https://pubmed.ncbi.nlm.nih.gov/41086178/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,39451229,Cryoprotective Potential of Theobromine in the Improvement of the Post-Thaw Quality of Bovine Spermatozoa.,2024,10.3390/cells13201710,https://pubmed.ncbi.nlm.nih.gov/39451229/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,38258300,Two novel heterozygous &lt;i&gt;ADCY10&lt;/i&gt; variants identified in Chinese pediatric patients with absorptive hypercalciuria: case report and literature review.,2024,10.1007/s12041-023-01458-2,https://pubmed.ncbi.nlm.nih.gov/38258300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,40896481,Differential lipid metabolism in beef cattle: A comparative study of high and low residual feed intake bulls.,2025,10.1016/j.aninu.2025.03.019,https://pubmed.ncbi.nlm.nih.gov/40896481/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,37039485,Soluble adenylyl cyclase contributes to imiquimod-mediated inflammation and is a potential therapeutic target in psoriasis.,2023,10.1111/exd.14811,https://pubmed.ncbi.nlm.nih.gov/37039485/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,36372953,Quantifying and mathematical modelling of the influence of soluble adenylate cyclase on cell cycle in human endothelial cells with Bayesian inference.,2022,10.1111/jcmm.17611,https://pubmed.ncbi.nlm.nih.gov/36372953/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,36346696,"Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.",2022,10.1021/acs.jmedchem.2c01133,https://pubmed.ncbi.nlm.nih.gov/36346696/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,33924969,Effect of Soluble Adenylyl Cyclase (ADCY10) Inhibitors on the LH-Stimulated cAMP Synthesis in Mltc-1 Leydig Cell Line.,2021,10.3390/ijms22094641,https://pubmed.ncbi.nlm.nih.gov/33924969/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,38886664,Selection signatures of wool color in Gangba sheep revealed by genome-wide SNP discovery.,2024,10.1186/s12864-024-10464-2,https://pubmed.ncbi.nlm.nih.gov/38886664/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,32307523,"Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public-private drug discovery institute collaboration†.",2020,10.1093/biolre/ioaa052,https://pubmed.ncbi.nlm.nih.gov/32307523/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,31119281,ADCY10 frameshift variant leading to severe recessive asthenozoospermia and segregating with absorptive hypercalciuria.,2019,10.1093/humrep/dez048,https://pubmed.ncbi.nlm.nih.gov/31119281/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,34413957,"Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).",2021,10.1021/acsmedchemlett.1c00273,https://pubmed.ncbi.nlm.nih.gov/34413957/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,29751653,Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments.,2018,10.3390/jcdd5020029,https://pubmed.ncbi.nlm.nih.gov/29751653/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,32259482,Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis.,2020,10.1016/j.cmet.2020.03.010,https://pubmed.ncbi.nlm.nih.gov/32259482/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,31985487,Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α.,2020,10.1172/jci99934,https://pubmed.ncbi.nlm.nih.gov/31985487/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,27627854,Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models.,2016,10.1038/srep33589,https://pubmed.ncbi.nlm.nih.gov/27627854/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,28249274,The Emerging Role of Soluble Adenylyl Cyclase in Primary Biliary Cholangitis.,2017,10.1159/000450914,https://pubmed.ncbi.nlm.nih.gov/28249274/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,17591988,Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP.,2007,10.1085/jgp.200709784,https://pubmed.ncbi.nlm.nih.gov/17591988/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,15659711,Cloning and characterization of the human soluble adenylyl cyclase.,2005,10.1152/ajpcell.00584.2004,https://pubmed.ncbi.nlm.nih.gov/15659711/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADCY10,ENSG00000143199,Unsafe,11932268,Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density.,2002,10.1210/jcem.87.4.8300,https://pubmed.ncbi.nlm.nih.gov/11932268/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,42284459,Ancient conservation of androglobin expression reveals its evolutionary link to ciliary processes.,2026,10.1093/molbev/msag147,https://pubmed.ncbi.nlm.nih.gov/42284459/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,41138754,Expression analysis of androglobin and its influence on the transcriptome in cancer.,2026,10.1016/j.gene.2025.149840,https://pubmed.ncbi.nlm.nih.gov/41138754/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,42759662,Calcium-dependent proteolysis of the chimeric androglobin reveals altered localization of its isolated globin domain.,2026,10.1016/j.jbc.2026.113582,https://pubmed.ncbi.nlm.nih.gov/42759662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,41834962,[Whole Exome Sequencing Identified Novel Pathogenic Mutations of &lt;i&gt;ADGB&lt;/i&gt; in Patients With Oligoasthenozoospermia].,2026,10.12182/20260160108,https://pubmed.ncbi.nlm.nih.gov/41834962/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,41200170,Complete cross strain protection against congenital cytomegalovirus infection requires a vaccine encoding key antibody (gB) and T-cell (immediate early 1 protein) viral antigens.,2025,10.3389/fimmu.2025.1649656,https://pubmed.ncbi.nlm.nih.gov/41200170/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,39719941,Calmodulin interacts with androglobin and regulates the nitrite reductase activity.,2025,10.1039/d4cb00245h,https://pubmed.ncbi.nlm.nih.gov/39719941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,38786048,Ectopic MYBL2-Mediated Regulation of Androglobin Gene Expression.,2024,10.3390/cells13100826,https://pubmed.ncbi.nlm.nih.gov/38786048/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,42056368,"Parent-of-origin effects in sheep: impact on the data fit, explanatory power of the model and theoretical accuracy of the breeding values.",2026,10.1038/s41598-026-50314-7,https://pubmed.ncbi.nlm.nih.gov/42056368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,41852679,Accelerated early weight gain of neonatal puppies from overweight bitches compared to lean dams in spite of similar milk macronutrient composition.,2026,10.3389/fnut.2026.1747221,https://pubmed.ncbi.nlm.nih.gov/41852679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,35700329,"Androglobin, a chimeric mammalian globin, is required for male fertility.",2022,10.7554/elife.72374,https://pubmed.ncbi.nlm.nih.gov/35700329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,38385883,Whole-exome sequencing identifies ADGB as a novel causative gene for male infertility in humans: from motility to fertilization.,2025,10.1111/andr.13605,https://pubmed.ncbi.nlm.nih.gov/38385883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,33453283,Androglobin gene expression patterns and FOXJ1-dependent regulation indicate its functional association with ciliogenesis.,2021,10.1016/j.jbc.2021.100291,https://pubmed.ncbi.nlm.nih.gov/33453283/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,37039991,CRISPR Activator Approaches to Study Endogenous Androglobin Gene Regulation.,2023,10.1007/978-1-0716-3080-8_11,https://pubmed.ncbi.nlm.nih.gov/37039991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,42327500,Ovine &lt;i&gt;ENSOARG00020011332&lt;/i&gt; rs427117280-GG provides an increase in weaning weight and average daily gain until weaning weight in a multi-breed sheep population.,2025,10.5194/aab-68-357-2025,https://pubmed.ncbi.nlm.nih.gov/42327500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,36543131,A molecular atlas of the human postmenopausal fallopian tube and ovary from single-cell RNA and ATAC sequencing.,2022,10.1016/j.celrep.2022.111838,https://pubmed.ncbi.nlm.nih.gov/36543131/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,37158461,Congenital heart defects caused by FOXJ1.,2023,10.1093/hmg/ddad065,https://pubmed.ncbi.nlm.nih.gov/37158461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,32863222,Lessons from the post-genomic era: Globin diversity beyond oxygen binding and transport.,2020,10.1016/j.redox.2020.101687,https://pubmed.ncbi.nlm.nih.gov/32863222/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,35872903,Proteomics Revealed That Mitochondrial Function Contributed to the Protective Effect of Herba Siegesbeckiae Against Cardiac Ischemia/Reperfusion Injury.,2022,10.3389/fcvm.2022.895797,https://pubmed.ncbi.nlm.nih.gov/35872903/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,33160411,LncRNA STXBP5-AS1 suppresses stem cell-like properties of pancreatic cancer by epigenetically inhibiting neighboring androglobin gene expression.,2020,10.1186/s13148-020-00961-y,https://pubmed.ncbi.nlm.nih.gov/33160411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,34083607,Composition and function of the C1b/C1f region in the ciliary central apparatus.,2021,10.1038/s41598-021-90996-9,https://pubmed.ncbi.nlm.nih.gov/34083607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADGB,ENSG00000118492,Unsafe,33729125,A trimeric capable gB CMV vaccine provides limited protection against a highly cell associated and epithelial tropic strain of cytomegalovirus in guinea pigs.,2021,10.1099/jgv.0.001579,https://pubmed.ncbi.nlm.nih.gov/33729125/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,42601945,Placental SNV rs8192446 in the &lt;i&gt;ADORA2A&lt;/i&gt; gene is associated with Preeclampsia: a pilot study.,2026,10.3389/fphys.2026.1843298,https://pubmed.ncbi.nlm.nih.gov/42601945/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,41533917,Inhibition of Retinal AdoRA2a Activity Attenuates Myopia Progression.,2026,10.1167/iovs.67.1.15,https://pubmed.ncbi.nlm.nih.gov/41533917/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,42620344,ADORA2A activation restores lysosomal function and photoreceptor outer segment degradation in stressed retinal pigment epithelium.,2026,10.3389/fphys.2026.1866784,https://pubmed.ncbi.nlm.nih.gov/42620344/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,41067595,Endothelial adenosine receptor 2A loss alleviates diabetic vascular calcification by blocking CREB1-SNAI1-driven EndMT.,2025,10.1016/j.phrs.2025.107981,https://pubmed.ncbi.nlm.nih.gov/41067595/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,42676036,Transcriptional Reprogramming of GPCR Signaling Pathways in the Frontal Cortex of Morphine Dependent Mice.,2026,10.4062/biomolther.2026.071,https://pubmed.ncbi.nlm.nih.gov/42676036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,41491207,Selective antagonism of adenosine A2A receptor reduces hypobaric hypoxia-induced neuroinflammation by inhibiting cGAS-STING pathway.,2026,10.1038/s41598-025-30717-8,https://pubmed.ncbi.nlm.nih.gov/41491207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,42700934,From diet to drinking behavior: Ketogenic diet decreases ethanol intake in young adult female mice.,2027,10.1016/j.bbr.2026.116465,https://pubmed.ncbi.nlm.nih.gov/42700934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,41201506,Targeting adenosine 2A receptor signaling suppresses vascular calcification by restraining smooth muscle osteogenic differentiation.,2025,10.1016/j.phrs.2025.108012,https://pubmed.ncbi.nlm.nih.gov/41201506/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,41892367,Changes in Blood DNA CpG Methylation Levels in Response to Methadone Maintenance Treatment: Epigenome-Wide Longitudinal Study.,2026,10.3390/epigenomes10010018,https://pubmed.ncbi.nlm.nih.gov/41892367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,42660457,Increased ADORA1 expression in pancreatic islets coincides with insulin secretory defects in human type 2 diabetes.,2026,10.1016/j.jbc.2026.113501,https://pubmed.ncbi.nlm.nih.gov/42660457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,42234312,"Expression of adenosine A1, A2A, A2B, and A3 receptors in ovarian cancer: their clinical potential in diagnosis and prognosis.",2026,10.1007/s11033-026-12052-x,https://pubmed.ncbi.nlm.nih.gov/42234312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,41175253,Caffeine consumption and behavioral symptoms: influence of ADORA2A and DRD2 genes on inattention.,2025,10.1007/s00394-025-03832-5,https://pubmed.ncbi.nlm.nih.gov/41175253/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,42389282,Multidimensional targeting of ischemia-reperfusion injury by genistein: from molecular crosstalk to clinical translation.,2026,10.3389/fphar.2026.1864013,https://pubmed.ncbi.nlm.nih.gov/42389282/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,41796158,A study on the mechanism of Buyang Huanwu Decoction in treating epilepsy by regulating adenosine levels.,2026,10.1038/s41598-026-41089-y,https://pubmed.ncbi.nlm.nih.gov/41796158/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,42626419,Genetic associations and candidate functional genes linking depression and obesity: a multi-omics integrative study.,2026,10.3389/fgene.2026.1855173,https://pubmed.ncbi.nlm.nih.gov/42626419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,41699832,Differential Expression of Endocannabinoid Receptors in Lesional and Non-Lesional Skin of Psoriasis Patients: Insights Into Pathogenesis and Potential Therapeutic Targets.,2026,10.1177/12034754251355199,https://pubmed.ncbi.nlm.nih.gov/41699832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,42088503,Caffeine-mediated CD39&lt;sup&gt;+&lt;/sup&gt; Treg activation via the CD39-adenosine receptor pathway is a novel risk factor for pulmonary tuberculosis.,2026,10.3389/fimmu.2026.1784235,https://pubmed.ncbi.nlm.nih.gov/42088503/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,39976204,Adenosine Monophosphate Improves Lipolysis in Obese Mice by Reducing DNA Methylation via ADORA2A Activation by Ecto-5'-Nucleotidase (CD73).,2025,10.1002/advs.202405079,https://pubmed.ncbi.nlm.nih.gov/39976204/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,42841809,Adenosine and ATP differentially control osteogenic gene expression patterns in a cardiac valve cell line.,2026,10.5603/cj.105530,https://pubmed.ncbi.nlm.nih.gov/42841809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,42474654,Chronic HBV Infection Disrupts CCL5-Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV-Specific T Cells.,2026,10.1002/advs.76696,https://pubmed.ncbi.nlm.nih.gov/42474654/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,41943838,Metabolic-Immune Coupling in Urologic Cancers: Macrophage Reprogramming as a Therapeutic Nexus.,2026,10.7150/ijbs.127634,https://pubmed.ncbi.nlm.nih.gov/41943838/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,41261949,Caffeine exacerbates exercise-induced gut cell damage and is influenced by ADORA2A genotype but not CYP1A2 genotype: A preliminary study.,2025,10.14814/phy2.70673,https://pubmed.ncbi.nlm.nih.gov/41261949/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,41209296,Data-driven assessment of bioisosteric replacements and their influence on off-target activity profiles.,2025,10.1039/d5md00686d,https://pubmed.ncbi.nlm.nih.gov/41209296/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,38731962,Clinical and Biologic Correlates of ADORA2A Transcriptomic Expression in Cancer.,2024,10.3390/ijms25094742,https://pubmed.ncbi.nlm.nih.gov/38731962/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,42180947,&lt;i&gt;CLIP2&lt;/i&gt; is a potential biomarker for platinum resistance and prognosis in ovarian cancer: a bioinformatics analysis.,2026,10.21037/tcr-2025-aw-2432,https://pubmed.ncbi.nlm.nih.gov/42180947/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,41775973,Integrative machine learning models reveal immune and metabolic signatures predictive of colorectal cancer prognosis.,2026,10.1007/s12672-026-04758-y,https://pubmed.ncbi.nlm.nih.gov/41775973/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,41892958,Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a &lt;i&gt;Porphyridium&lt;/i&gt; Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract.,2026,10.3390/md24030099,https://pubmed.ncbi.nlm.nih.gov/41892958/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,41142241,Identification of galangin as a therapeutic candidate for primary biliary cholangitis via systematic druggable genome-wide Mendelian randomization analysis and experimental validation.,2025,10.3389/fphar.2025.1674693,https://pubmed.ncbi.nlm.nih.gov/41142241/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,41073355,Surface d-Band Modulation via Biodirected Mineralization Enables Nanoenzymes to Inhibit Radiation-Induced T-Cell Exhaustion and Potentiate Immunoradiotherapy.,2025,10.1021/acsnano.5c09444,https://pubmed.ncbi.nlm.nih.gov/41073355/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,41276526,Multiplex gene-editing strategy to engineer allogeneic EGFR-targeting CAR T-cells with improved efficacy against solid tumors.,2025,10.1038/s41467-025-66737-1,https://pubmed.ncbi.nlm.nih.gov/41276526/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ADORA2A,ENSG00000128271,Unsafe,42393904,Cross-System Transcriptomics Suggests Enterovirus A71 Exploits Wound Healing Programs to Target Neural Progenitors in Human Spinal Cord Organoids.,2026,10.2174/0118715265495604260618201203,https://pubmed.ncbi.nlm.nih.gov/42393904/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,42811695,AFF4 Loss Compromises Osteogenesis of Orofacial Mesenchymal Stem Cells During Alveolar Bone Repair via AMPK-Mediated Mitophagy.,2026,10.1111/cpr.70284,https://pubmed.ncbi.nlm.nih.gov/42811695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,42273204,CHOPS Syndrome: A Rare Malformation Syndrome with de novo AFF4 Gene Variant.,2026,10.1159/000551813,https://pubmed.ncbi.nlm.nih.gov/42273204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,41296873,MeCP2 interacts with the super elongation complex to regulate transcription.,2025,10.1126/sciadv.adt5937,https://pubmed.ncbi.nlm.nih.gov/41296873/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,40790766,AFF4 promotes tumor progression and cisplatin resistance by modulating the PTEN/PI3K/AKT/mTOR axis to accelerate glycolysis in lung adenocarcinoma.,2025,10.1186/s13578-025-01455-1,https://pubmed.ncbi.nlm.nih.gov/40790766/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,41476161,Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator.,2025,10.1038/s41467-025-68106-4,https://pubmed.ncbi.nlm.nih.gov/41476161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,42749708,Targeting super elongation complex-driven RNA polymerase II elongation reduces plaque vulnerability.,2026,10.1038/s41392-026-02962-4,https://pubmed.ncbi.nlm.nih.gov/42749708/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,42801698,NS1-Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication.,2026,10.1002/advs.77883,https://pubmed.ncbi.nlm.nih.gov/42801698/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,42010438,CircAFF4 inhibits lung cancer progression via destabilizing GPX4 and triggering ferroptosis.,2026,10.1186/s13062-026-00782-8,https://pubmed.ncbi.nlm.nih.gov/42010438/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,42497103,Diagnostic and prognosis of benign and malignant early pulmonary nodules using serum miR-500a-3p combined with CT signs.,2026,10.1080/15257770.2026.2697800,https://pubmed.ncbi.nlm.nih.gov/42497103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,40432319,Cinobufagin regulates the microRNA-149-3p/AFF4 axis to affect the proliferation and apoptosis of cisplatin-resistant ovarian cancer cells.,2026,10.1080/1120009x.2025.2508614,https://pubmed.ncbi.nlm.nih.gov/40432319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,42748909,A dual-module ECAS complex couples transcription elongation and RNA processing.,2026,10.1016/j.molcel.2026.08.019,https://pubmed.ncbi.nlm.nih.gov/42748909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,39572480,"FENDRR represses Bladder Cancer Cell Proliferation, Stemness, Migration, Invasion, and EMT Process by Targeting miR-18a-5p/AFF4 Axis.",2025,10.1007/s10528-024-10944-w,https://pubmed.ncbi.nlm.nih.gov/39572480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,40904637,Identification of a novel &lt;i&gt;de novo AFF4&lt;/i&gt; variant (c.778A&gt;G) associated with CHOPS syndrome.,2025,10.5582/irdr.2025.01041,https://pubmed.ncbi.nlm.nih.gov/40904637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,42555419,A biomechanical study of a novel multi axial circular external fixation device for stabilization of a bovine cadaveric tibial fracture gap model.,2025,10.22099/ijvr.2025.51532.7656,https://pubmed.ncbi.nlm.nih.gov/42555419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,40457291,Latitude-driven adaptive evolution of body length in diverse pig breeds across China.,2025,10.1186/s12915-025-02265-0,https://pubmed.ncbi.nlm.nih.gov/40457291/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,37731335,AFF4 regulates osteogenic potential of human periodontal ligament stem cells via mTOR-ULK1-autophagy axis.,2024,10.1111/cpr.13546,https://pubmed.ncbi.nlm.nih.gov/37731335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,42497608,Taurine ameliorates damages induced by acute heat stress on porcine Sertoli cells.,2026,10.1016/j.theriogenology.2026.118104,https://pubmed.ncbi.nlm.nih.gov/42497608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,39414635,N6-methyladenosine-modified circCDK14 promotes ossification of the ligamentum flavum via epigenetic modulation by targeting AFF4.,2024,10.1007/s00018-024-05460-4,https://pubmed.ncbi.nlm.nih.gov/39414635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,40017037,Transcriptome-wide analyses delineate the genetic architecture of expression variation in atopic dermatitis.,2025,10.1016/j.xhgg.2025.100422,https://pubmed.ncbi.nlm.nih.gov/40017037/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,37063434,PI3K/ c-Myc/AFF4 axis promotes pancreatic tumorigenesis through fueling nucleotide metabolism.,2023,10.7150/ijbs.77150,https://pubmed.ncbi.nlm.nih.gov/37063434/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,41712746,AFF4-Related CHOPS Syndrome,1993,,https://pubmed.ncbi.nlm.nih.gov/41712746/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,40778544,"Unraveling the dual role of METTL3-mediated m&lt;sup&gt;6&lt;/sup&gt;A RNA modification in bladder cancer: mechanisms, therapeutic vulnerabilities, and clinical implications.",2025,10.1080/15384047.2025.2545057,https://pubmed.ncbi.nlm.nih.gov/40778544/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,38203475,"Multiple Genomic Alterations, Including a Novel AFF4::IRF1 Fusion Gene, in a Treatment-Refractory Blastic Plasmacytoid Dendritic-Cell Neoplasm: A Case Report and Literature Review.",2023,10.3390/ijms25010305,https://pubmed.ncbi.nlm.nih.gov/38203475/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,38116315,Impact of disulfidptosis-associated clusters on breast cancer survival rates and guiding personalized treatment.,2023,10.3389/fendo.2023.1256132,https://pubmed.ncbi.nlm.nih.gov/38116315/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,35223479,AFF4 Predicts the Prognosis of Colorectal Cancer Patients and Suppresses Colorectal Cancer Metastasis via Promoting CDH1 Expression.,2022,10.3389/fonc.2022.797392,https://pubmed.ncbi.nlm.nih.gov/35223479/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,39743445,Rare gene variants and weight loss at 10 years after sleeve gastrectomy and gastric bypass - a randomized clinical trial.,2025,10.1016/j.soard.2024.11.021,https://pubmed.ncbi.nlm.nih.gov/39743445/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,34373735,Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth.,2021,10.7150/thno.56737,https://pubmed.ncbi.nlm.nih.gov/34373735/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,37949879,PRMT2 promotes HIV-1 latency by preventing nucleolar exit and phase separation of Tat into the Super Elongation Complex.,2023,10.1038/s41467-023-43060-1,https://pubmed.ncbi.nlm.nih.gov/37949879/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,33369874,Modeling by disruption and a selected-for partner for the nude locus.,2021,10.15252/embr.201949804,https://pubmed.ncbi.nlm.nih.gov/33369874/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,33554445,Flash forward genetics: new twists in transcription across evolutionary boundaries.,2021,10.15252/embr.202052152,https://pubmed.ncbi.nlm.nih.gov/33554445/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,36989355,The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma.,2023,10.1126/sciadv.adf0005,https://pubmed.ncbi.nlm.nih.gov/36989355/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,32265480,Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha.,2020,10.1038/s42003-020-0898-0,https://pubmed.ncbi.nlm.nih.gov/32265480/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,32012033,Iterative Learning Control for MIMO Nonlinear Systems With Iteration-Varying Trial Lengths Using Modified Composite Energy Function Analysis.,2021,10.1109/tcyb.2020.2966625,https://pubmed.ncbi.nlm.nih.gov/32012033/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,12065898,"MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein.",2002,10.1007/bf02256070,https://pubmed.ncbi.nlm.nih.gov/12065898/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFF4,ENSG00000072364,Unsafe,10588740,"AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23).",1999,10.1073/pnas.96.25.14535,https://pubmed.ncbi.nlm.nih.gov/10588740/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,41865124,Identifying genetic contributions of 6q21 loci and PPAR pathway to antipsychotic-induced metabolic syndrome: a Sex-Stratified Multi-Omics study.,2026,10.1038/s41380-026-03544-0,https://pubmed.ncbi.nlm.nih.gov/41865124/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,39511428,Lactate utilization in Lace1 knockout mice promotes browning of inguinal white adipose tissue.,2024,10.1038/s12276-024-01324-w,https://pubmed.ncbi.nlm.nih.gov/39511428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,42188632,"Multi-Mycotoxin Occurrence and Health Risk Assessment in Early Post-Harvest Durum Wheat, Barley, and Maize from Tunisia.",2026,10.3390/toxins18050230,https://pubmed.ncbi.nlm.nih.gov/42188632/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,40409516,Deciphering the regulatory networks of human male germline development from embryo to adulthood.,2025,10.1016/j.bbadis.2025.167918,https://pubmed.ncbi.nlm.nih.gov/40409516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,42594659,"Research progress on core preparation variables, detection methods, and sensing performances of molecularly imprinted polymers (MIPs) for aflatoxins determination.",2026,10.1016/j.foodchem.2026.150614,https://pubmed.ncbi.nlm.nih.gov/42594659/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,40204712,Development of a breast cancer invasion score to predict tumor aggressiveness and prognosis via PI3K/AKT/mTOR pathway analysis.,2025,10.1038/s41420-025-02422-y,https://pubmed.ncbi.nlm.nih.gov/40204712/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,36704432,"Aflatoxin G1 exposure altered the expression of BDNF and GFAP, histopathological of brain tissue, and oxidative stress factors in male rats.",2022,10.4103/1735-5362.359434,https://pubmed.ncbi.nlm.nih.gov/36704432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,42467202,"Elucidating targets and mechanisms of dietary mycotoxin carcinogenesis via network toxicology, pan-cancer analysis, and molecular simulation.",2026,10.1007/s00210-026-05708-9,https://pubmed.ncbi.nlm.nih.gov/42467202/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,41135147,Innovative hierarchical porous covalent organic frameworks for enrichment and purification of aflatoxins.,2025,10.1016/j.foodchem.2025.146739,https://pubmed.ncbi.nlm.nih.gov/41135147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,42142814,Nitric oxide initiates early differentiation events in Leishmania infantum stage transition.,2026,10.1016/j.freeradbiomed.2026.05.301,https://pubmed.ncbi.nlm.nih.gov/42142814/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,42550348,"Quantification of aflatoxins and sterigmatocystin in walnuts, cashews, pistachios, peanuts, and hazelnuts by using UHPLC-MS/MS following Aspergillus flavus inoculation.",2026,10.1007/s12550-026-00666-w,https://pubmed.ncbi.nlm.nih.gov/42550348/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,40443238,Unravelling the Mechanistic Approach of Aflatoxin Contaminated Food on Neurodegenerative Diseases-A Novel Approach.,2025,10.1002/jat.4817,https://pubmed.ncbi.nlm.nih.gov/40443238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,41008149,Simultaneous Presence of Mycotoxins in Feed Intended for Food-Producing Animals.,2025,10.3390/foods14183176,https://pubmed.ncbi.nlm.nih.gov/41008149/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,39891869,Comprehensive review for aflatoxin detoxification with special attention to cold plasma treatment.,2025,10.1007/s12550-025-00582-5,https://pubmed.ncbi.nlm.nih.gov/39891869/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,34084205,"Expression of cyclin D1, p21, and estrogen receptor alpha in aflatoxin G1-induced disturbance in testicular tissue of albino mice.",2021,10.4103/1735-5362.310525,https://pubmed.ncbi.nlm.nih.gov/34084205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,39047489,"Analysis and evaluation of in vitro bioaccessibility of aflatoxins B1, B2, G1 and G2 in plant-based milks.",2024,10.1016/j.foodchem.2024.140538,https://pubmed.ncbi.nlm.nih.gov/39047489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,26759378,The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits.,2016,10.1042/bj20151029,https://pubmed.ncbi.nlm.nih.gov/26759378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,40231926,Effect of Baking Conditions on Mycotoxin Levels in Flatbreads Prepared from Artificially Contaminated Doughs.,2025,10.3390/foods14060910,https://pubmed.ncbi.nlm.nih.gov/40231926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,27323408,LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis.,2016,10.18632/oncotarget.9959,https://pubmed.ncbi.nlm.nih.gov/27323408/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,38668598,Meat Starter Culture Reduces &lt;i&gt;Aspergillus parasiticus&lt;/i&gt; Production of Aflatoxins on Meat-Based and Salami Model Media.,2024,10.3390/toxins16040173,https://pubmed.ncbi.nlm.nih.gov/38668598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,42677651,Rational Design of a Dual Mutant Degrading Enzyme with Improved Catalytic Efficiency and Acid Tolerance for Four Aflatoxins.,2026,10.1021/acs.jafc.6c03843,https://pubmed.ncbi.nlm.nih.gov/42677651/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,41400279,Occurrence of aflatoxins in rice (&lt;i&gt;Oryza sativa&lt;/i&gt; L.) produced in Colombia.,2026,10.4081/ijfs.2025.14298,https://pubmed.ncbi.nlm.nih.gov/41400279/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,42668490,Dual-mode screening system for rapid and accurate aflatoxin B1 detection in edible oils.,2026,10.1016/j.fochx.2026.104325,https://pubmed.ncbi.nlm.nih.gov/42668490/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,42501160,Eleven-year monitoring of aflatoxins in hazelnuts from Türkiye: occurrence and regulatory compliance.,2026,10.1007/s12550-026-00663-z,https://pubmed.ncbi.nlm.nih.gov/42501160/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,40169676,Novel Ni/Fe-MIL-53@ZnO nanocomposite for efficient photodegradation of aflatoxins G1 and G2.,2025,10.1038/s41598-025-94863-9,https://pubmed.ncbi.nlm.nih.gov/40169676/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,40714115,Ultraviolet processing for mycotoxin mitigation: A sustainable approach to enhancing food safety and security.,2025,10.1016/j.toxicon.2025.108505,https://pubmed.ncbi.nlm.nih.gov/40714115/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,42621599,"Metals, pesticides, and mycotoxins oral exposure via potato chips ingestion: A Monte Carlo-simulation risk assessment for Iranian consumers.",2026,10.1016/j.toxrep.2026.102327,https://pubmed.ncbi.nlm.nih.gov/42621599/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,39588463,Fluorescence spectroscopy and molecular modeling studies on the interaction of aflatoxin B1 and G1 with bovine α-lactalbumin.,2024,10.30466/vrf.2024.2006492.3959,https://pubmed.ncbi.nlm.nih.gov/39588463/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,39886046,"Dietary exposure to aflatoxin B1, aflatoxin G1, ochratoxin A, and patulin through fruit juice consumption: A probabilistic assessment of health risk.",2025,10.1016/j.toxrep.2025.101894,https://pubmed.ncbi.nlm.nih.gov/39886046/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,40563974,Study on the Degradation of Aflatoxin B1 by &lt;i&gt;Myroides odoratimimus&lt;/i&gt; 3J2MO.,2025,10.3390/biology14060724,https://pubmed.ncbi.nlm.nih.gov/40563974/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,40711128,"Comprehensive Analysis of Mycotoxins in Green Coffee Food Supplements: Method Development, Occurrence, and Health Risk Assessment.",2025,10.3390/toxins17070316,https://pubmed.ncbi.nlm.nih.gov/40711128/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG1L,ENSG00000135537,Unsafe,41564778,Validated DLLME-LC-MS/MS for rapid determination of aflatoxins in commercial seasoning powders.,2026,10.1016/j.foodchem.2026.148032,https://pubmed.ncbi.nlm.nih.gov/41564778/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,41933351,"AFG2A-related encephalopathy, expanding the neurodevelopmental and epileptic spectrum.",2026,10.1186/s13023-026-04204-w,https://pubmed.ncbi.nlm.nih.gov/41933351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,42743181,"Linkages between lifestyle practices, dietary habits, and premenstrual syndrome among college students.",2026,10.1371/journal.pgph.0007266,https://pubmed.ncbi.nlm.nih.gov/42743181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,41019454,Clinical manifestation and pathological changes of serous papillary adenofibroma: A case series.,2025,10.3892/mco.2025.2893,https://pubmed.ncbi.nlm.nih.gov/41019454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,40712368,AFG2A-related encephalopathy: Effectiveness of ketogenic diet in epilepsy and mitochondrial dynamics modulation.,2025,10.1016/j.ejpn.2025.07.007,https://pubmed.ncbi.nlm.nih.gov/40712368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,40268917,Cryo-EM structure of the AAA+ SPATA5 complex and its role in human cytoplasmic pre-60S maturation.,2025,10.1038/s41467-025-58894-0,https://pubmed.ncbi.nlm.nih.gov/40268917/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,42129325,S-PrediXcan predicted gene expression in human placenta is associated with childhood-onset asthma risk.,2026,10.1038/s41598-026-51718-1,https://pubmed.ncbi.nlm.nih.gov/42129325/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,36849973,Computational and mitochondrial functional studies of novel compound heterozygous variants in SPATA5 gene support a causal link with epileptogenic encephalopathy.,2023,10.1186/s40246-023-00463-x,https://pubmed.ncbi.nlm.nih.gov/36849973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,40558542,Exome Study of Single Nucleotide Variations in Patients with Syndromic and Non-Syndromic Autism Reveals Potential Candidate Genes for Diagnostics and Novel Single Nucleotide Variants.,2025,10.3390/cells14120915,https://pubmed.ncbi.nlm.nih.gov/40558542/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,42713441,"Dietary, Lifestyle, and Psychological Factors Associated with Premenstrual Syndrome Among Female University Students in Saudi Arabia: A Cross-Sectional Study.",2026,10.2147/ijwh.s639146,https://pubmed.ncbi.nlm.nih.gov/42713441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,42156804,"Aerobic capacity at age 34 predicts arterial stiffness in age 63, independent of classical and advanced lipid-related cardiovascular risk factors: a longitudinal cohort study.",2026,10.1038/s41598-026-52389-8,https://pubmed.ncbi.nlm.nih.gov/42156804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,40778670,Confined Polymer Electrolyte Synthesis in Porous Frameworks for Cold-Climate Zinc-Ion Batteries.,2025,10.1002/adma.202511029,https://pubmed.ncbi.nlm.nih.gov/40778670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,41243424,Rise and Fall of Physical Capacity in a General Population: A 47-Year Longitudinal Study.,2025,10.1002/jcsm.70134,https://pubmed.ncbi.nlm.nih.gov/41243424/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,42073338,Mechanistic and Structural Analysis of Aflatoxin B1 Degradation by &lt;i&gt;Bacillus safensis&lt;/i&gt; Multicopper Oxidase.,2026,10.3390/foods15081451,https://pubmed.ncbi.nlm.nih.gov/42073338/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,40071748,Investigating Motor Coordination Using BXD Recombinant Inbred Mice to Model the Genetic Underpinnings of Developmental Coordination Disorder.,2025,10.1111/gbb.70014,https://pubmed.ncbi.nlm.nih.gov/40071748/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,40603987,Genetic etiology of ventriculomegaly in 73 fetuses identified by High-Throughput sequencing.,2025,10.1038/s41598-025-06714-2,https://pubmed.ncbi.nlm.nih.gov/40603987/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,38554706,The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity.,2024,10.1016/j.cell.2024.03.002,https://pubmed.ncbi.nlm.nih.gov/38554706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,39518882,Genomic Insights into Pig Domestication and Adaptation: An Integrated Approach Using Genome-Wide Selection Analysis and Multiple Public Datasets.,2024,10.3390/ani14213159,https://pubmed.ncbi.nlm.nih.gov/39518882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,34360601,Muscular and Molecular Pathology Associated with SPATA5 Deficiency in a Child with EHLMRS.,2021,10.3390/ijms22157835,https://pubmed.ncbi.nlm.nih.gov/34360601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,35354024,Labeling of heterochronic ribosomes reveals C1ORF109 and SPATA5 control a late step in human ribosome assembly.,2022,10.1016/j.celrep.2022.110597,https://pubmed.ncbi.nlm.nih.gov/35354024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,41362461,Linking Premenstrual Syndrome With Salivary Alpha-Amylase Levels and Stress Levels: A Cross-Sectional Study.,2025,10.18502/jfrh.v19i3.20058,https://pubmed.ncbi.nlm.nih.gov/41362461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,41299993,"Effects of Treatment Methods on the Formation, Structure, and Functional Properties of Soy Protein Amyloid Fibrils.",2025,10.3390/foods14223835,https://pubmed.ncbi.nlm.nih.gov/41299993/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,39213977,"Individualized homeopathic medicines in the treatment of premenstrual syndrome: A double-blind, randomized, placebo-controlled trial.",2024,10.1016/j.explore.2024.103039,https://pubmed.ncbi.nlm.nih.gov/39213977/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,38394987,Patterns of atrial fibrillation anticoagulation with rivaroxaban - 7-year follow-up from the Dresden NOAC registry.,2024,10.1016/j.thromres.2024.02.014,https://pubmed.ncbi.nlm.nih.gov/38394987/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,37953916,A stream processing abstraction framework.,2023,10.3389/fdata.2023.1227156,https://pubmed.ncbi.nlm.nih.gov/37953916/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,35623105,Effectiveness and safety of edoxaban therapy in daily-care patients with atrial fibrillation. Results from the DRESDEN NOAC REGISTRY.,2022,10.1016/j.thromres.2022.05.010,https://pubmed.ncbi.nlm.nih.gov/35623105/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,36809113,Genome-Scale CRISPR Screening Reveals Host Factors Required for Ribosome Formation and Viral Replication.,2023,10.1128/mbio.00127-23,https://pubmed.ncbi.nlm.nih.gov/36809113/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,35232067,Making sense of periodicity glimpses in a prediction-update-loop-A computational model of attentive voice tracking.,2022,10.1121/10.0009337,https://pubmed.ncbi.nlm.nih.gov/35232067/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,37324774,Net clinical benefit of oral anticoagulants in Korean atrial fibrillation patients with low to intermediate stroke risk: A report from the Clinical Survey on Stroke Prevention in patients with Atrial Fibrillation (CS-SPAF).,2023,10.1002/joa3.12840,https://pubmed.ncbi.nlm.nih.gov/37324774/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,31959803,Comparative efficacy and safety of warfarin care bundles and novel oral anticoagulants in patients with atrial fibrillation: a systematic review and network meta-analysis.,2020,10.1038/s41598-019-57370-2,https://pubmed.ncbi.nlm.nih.gov/31959803/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,30347966,Dabigatran - the First Approved DTI for SPAF.,2018,,https://pubmed.ncbi.nlm.nih.gov/30347966/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,31903008,Cost-Effectiveness Analysis of Oral Anticoagulants in Stroke Prevention among Patients with Atrial Fibrillation in Taiwan.,2020,10.6515/acs.202001_36(1).20190511a,https://pubmed.ncbi.nlm.nih.gov/31903008/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,33862399,Stroke risk associated with carotid and aortic atherosclerosis in patients with atrial fibrillation: A systematic review.,2021,10.1016/j.jns.2021.117444,https://pubmed.ncbi.nlm.nih.gov/33862399/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,25018102,Common flaws exist in published cost-effectiveness models of pharmacologic stroke prevention in atrial fibrillation.,2014,10.1016/j.jclinepi.2014.05.013,https://pubmed.ncbi.nlm.nih.gov/25018102/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,25694537,Drug persistence with rivaroxaban therapy in atrial fibrillation patients-results from the Dresden non-interventional oral anticoagulation registry.,2015,10.1093/europace/euu319,https://pubmed.ncbi.nlm.nih.gov/25694537/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AFG2A,ENSG00000145375,Unsafe,26791999,Effectiveness and safety of rivaroxaban therapy in daily-care patients with atrial fibrillation. Results from the Dresden NOAC Registry.,2016,10.1160/th15-10-0840,https://pubmed.ncbi.nlm.nih.gov/26791999/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,41194443,CRISPR/Cas9-mediated genome editing identifies six testis-expressed genes individually dispensable for overt male fecundity in mice.,2026,10.7555/jbr.39.20250247,https://pubmed.ncbi.nlm.nih.gov/41194443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,40369660,Correction to: Clinical implications of AGBL2 expression and its inhibitor latexin in breast cancer.,2025,10.1186/s12957-025-03831-0,https://pubmed.ncbi.nlm.nih.gov/40369660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,39315218,AGBL2 promotes renal cell carcinoma cells proliferation and migration via α-tubulin detyrosination.,2024,10.1016/j.heliyon.2024.e37086,https://pubmed.ncbi.nlm.nih.gov/39315218/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,42207556,Association of the rs7574865 polymorphism in the signal transducer and activator of transcription 4 gene with rheumatoid arthritis in Moroccan patients.,2026,10.55563/clinexprheumatol/mf8noj,https://pubmed.ncbi.nlm.nih.gov/42207556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,41672721,Autoantibodies as predictors of progression to rheumatoid arthritis: a systematic review and meta-analysis.,2026,10.1136/rmdopen-2025-006368,https://pubmed.ncbi.nlm.nih.gov/41672721/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,41292126,The Effect and Its Mechanism of a Novel Disintegrin GbvIV4 From Gloydius brevicaudus Venom on Inhibition Metastasis of Melanoma Cells.,2026,10.1002/jat.4990,https://pubmed.ncbi.nlm.nih.gov/41292126/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,39959134,Anti-citrullinated protein antibody detection by hemagglutination.,2025,10.1093/rap/rkaf010,https://pubmed.ncbi.nlm.nih.gov/39959134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,42839246,Temporal dynamics of inflammatory proteins in the pre-symptomatic phase of rheumatoid arthritis related to seroconversion.,2026,10.1186/s13075-026-03917-4,https://pubmed.ncbi.nlm.nih.gov/42839246/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,39931747,Rheumatoid Arthritis Related B-Cell Changes Are Found Already in the Risk-RA Phase.,2025,10.1002/eji.202451391,https://pubmed.ncbi.nlm.nih.gov/39931747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,40819168,Randomized phase I trial outcomes show safe and sustainable inhibition of classical and lectin complement pathways by empasiprubart.,2025,10.1038/s41467-025-62925-1,https://pubmed.ncbi.nlm.nih.gov/40819168/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,39863304,Distinct clinical outcomes based on multiple serum cytokine and chemokine profiles rather than autoantibody profiles and ultrasound findings in rheumatoid arthritis: a prospective ultrasound cohort study.,2025,10.1136/rmdopen-2024-005163,https://pubmed.ncbi.nlm.nih.gov/39863304/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,39890206,"&lt;i&gt;Porphyromonas gingivalis&lt;/i&gt; associates with the presence of anti-citrullinated protein antibodies, but not with the onset of arthritis: studies in an at-risk population.",2025,10.1136/rmdopen-2024-005111,https://pubmed.ncbi.nlm.nih.gov/39890206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,38790926,Exhaled Nitric Oxide Reflects the Immune Reactions of the Airways in Early Rheumatoid Arthritis.,2024,10.3390/biomedicines12050964,https://pubmed.ncbi.nlm.nih.gov/38790926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,42080322,"Structure-function analysis of empasiprubart, a calcium- and pH-dependent clinical phase complement C2 blocking antibody.",2026,10.1080/19420862.2026.2666430,https://pubmed.ncbi.nlm.nih.gov/42080322/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,40116570,"Recognition of Glycine Versus Nonglycine Citrulline Motifs Dictating the HLA Class II Association of Anticitrullinated Protein Antibodies: Insights From Autoantibody Profiling of 6,900 Scandinavian Patients With Rheumatoid Arthritis.",2025,10.1002/art.43161,https://pubmed.ncbi.nlm.nih.gov/40116570/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,40106366,"Identifying Data-Driven Clinical Subgroups for Cervical Cancer Prevention With Machine Learning: Population-Based, External, and Diagnostic Validation Study.",2025,10.2196/67840,https://pubmed.ncbi.nlm.nih.gov/40106366/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,36424922,Extraction and immunomodulatory activity of the polysaccharide obtained from Craterellus cornucopioides.,2022,10.3389/fnut.2022.1017431,https://pubmed.ncbi.nlm.nih.gov/36424922/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,32307444,Expression of RARRES1 and AGBL2 and progression of conventional renal cell carcinoma.,2020,10.1038/s41416-020-0798-6,https://pubmed.ncbi.nlm.nih.gov/32307444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,38945553,Autoantibody-positivity before and seroconversion during treatment with anti-PD-1 is associated with immune-related adverse events in patients with melanoma.,2024,10.1136/jitc-2024-009215,https://pubmed.ncbi.nlm.nih.gov/38945553/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,39557489,Arthritis progressors have a decreased frequency of circulating autoreactive T cells during the at-risk phase of rheumatoid arthritis.,2024,10.1136/rmdopen-2024-004510,https://pubmed.ncbi.nlm.nih.gov/39557489/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,39002123,The impact of periodontitis and periodontal treatment on rheumatoid arthritis outcomes: an exploratory clinical trial.,2025,10.1093/rheumatology/keae358,https://pubmed.ncbi.nlm.nih.gov/39002123/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,40118130,Diffuse large B cell lymphoma in rheumatoid arthritis patients is associated with elevated B-cell driving factors including CXCL13.,2025,10.1016/j.clim.2025.110476,https://pubmed.ncbi.nlm.nih.gov/40118130/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,38599655,Utility of testing for third-generation anticyclic citrullinated peptide (anti-CCP3) antibodies in individuals who present with new musculoskeletal symptoms but have a negative second-generation anticyclic citrullinated peptide (anti-CCP2) antibody test.,2024,10.1136/rmdopen-2023-003927,https://pubmed.ncbi.nlm.nih.gov/38599655/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,36085230,Mechanistic insights into HuR inhibitor MS-444 arresting embryonic development revealed by low-input RNA-seq and STORM.,2022,10.1007/s10565-022-09757-7,https://pubmed.ncbi.nlm.nih.gov/36085230/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,36685579,The diagnostic and prognostic value of IgG and IgA anti-citrullinated protein antibodies in patients with early rheumatoid arthritis.,2022,10.3389/fimmu.2022.1096866,https://pubmed.ncbi.nlm.nih.gov/36685579/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,35885675,Anti-Citrullinated Protein Antibody Titers Are Independently Modulated by Both Disease Activity and Conventional or Biologic Anti-Rheumatic Drugs.,2022,10.3390/diagnostics12071773,https://pubmed.ncbi.nlm.nih.gov/35885675/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,36724282,"HACCP plan for microbiological hazards associated with fermented crab, Episesarma mederi H. Milne Edwards 1853.",2023,10.1093/jambio/lxac087,https://pubmed.ncbi.nlm.nih.gov/36724282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL2,ENSG00000165923,Unsafe,34878629,Differential Changes in ACPA Fine Specificity and Gene Expression in a Randomized Trial of Abatacept and Adalimumab in Rheumatoid Arthritis.,2022,10.1007/s40744-021-00404-x,https://pubmed.ncbi.nlm.nih.gov/34878629/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,42011761,Tubulin hyperglutamylation induces retinal degeneration by disrupting ciliary architecture and protein trafficking.,2026,10.24272/j.issn.2095-8137.2025.321,https://pubmed.ncbi.nlm.nih.gov/42011761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,40926193,Rescue of ciliogenesis and hyperglutamylation mutant phenotype in AGBL5&lt;sup&gt;-/-&lt;/sup&gt; cell model of retinitis pigmentosa.,2025,10.1186/s12860-025-00551-x,https://pubmed.ncbi.nlm.nih.gov/40926193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,42326015,Tubulin monoglutamylation is sufficient to rescue the ciliary motility defects in a &lt;i&gt;Chlamydomonas&lt;/i&gt; polyglutamylation deficient mutant.,2026,10.3389/fcell.2026.1857091,https://pubmed.ncbi.nlm.nih.gov/42326015/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,39672920,Variants in the AGBL5 gene are responsible for autosomal recessive Retinitis pigmentosa with hearing loss.,2025,10.1038/s41431-024-01768-8,https://pubmed.ncbi.nlm.nih.gov/39672920/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,41351017,A cross-tissue transcriptome-wide association study identifies novel candidate genes associated with brain glymphatic system function.,2025,10.1186/s13041-025-01258-y,https://pubmed.ncbi.nlm.nih.gov/41351017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,39528655,Glutamylation imbalance impairs the molecular architecture of the photoreceptor cilium.,2024,10.1038/s44318-024-00284-1,https://pubmed.ncbi.nlm.nih.gov/39528655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,39020174,Tubulin code eraser CCP5 binds branch glutamates by substrate deformation.,2024,10.1038/s41586-024-07699-0,https://pubmed.ncbi.nlm.nih.gov/39020174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,38297980,Excessive tubulin glutamylation leads to progressive cone-rod dystrophy and loss of outer segment integrity.,2024,10.1093/hmg/ddae013,https://pubmed.ncbi.nlm.nih.gov/38297980/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,37226238,CCP5 and CCP6 retain CP110 and negatively regulate ciliogenesis.,2023,10.1186/s12915-023-01622-1,https://pubmed.ncbi.nlm.nih.gov/37226238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,26720455,Exome Sequencing Reveals AGBL5 as Novel Candidate Gene and Additional Variants for Retinitis Pigmentosa in Five Turkish Families.,2015,10.1167/iovs.15-17473,https://pubmed.ncbi.nlm.nih.gov/26720455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,35242841,Identification of CCp5 and FNPA as Novel Non-canonical Members of the CCp Protein Family in Babesia bovis.,2022,10.3389/fvets.2022.833183,https://pubmed.ncbi.nlm.nih.gov/35242841/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,28128286,Role of Cytosolic Carboxypeptidase 5 in Neuronal Survival and Spermatogenesis.,2017,10.1038/srep41428,https://pubmed.ncbi.nlm.nih.gov/28128286/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,39920028,Characterization of tubulin post-translational modifications and their enzymes during human oocyte meiosis.,2025,10.1016/j.rbmo.2024.103885,https://pubmed.ncbi.nlm.nih.gov/39920028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,36264433,Dysregulation of Circulatory Levels of lncRNAs in Parkinson's Disease.,2023,10.1007/s12035-022-03086-w,https://pubmed.ncbi.nlm.nih.gov/36264433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,35892439,Unilateral Retinitis Pigmentosa Associated with Possible Ciliopathy and a Novel Mutation.,2022,10.3390/clinpract12040053,https://pubmed.ncbi.nlm.nih.gov/35892439/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,36285326,A ccpp-6 deletion mutation does not impair gross cilia integrity in C. elegans.,2022,10.17912/micropub.biology.000649,https://pubmed.ncbi.nlm.nih.gov/36285326/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,36743550,Abscisic acid agonists suitable for optimizing plant water use.,2022,10.3389/fpls.2022.1071710,https://pubmed.ncbi.nlm.nih.gov/36743550/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,24022483,Zebrafish cytosolic carboxypeptidases 1 and 5 are essential for embryonic development.,2013,10.1074/jbc.m113.497933,https://pubmed.ncbi.nlm.nih.gov/24022483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,36267860,Exome Sequencing Reveals De Novo Variants in Congenital Scoliosis.,2022,10.1055/s-0041-1726282,https://pubmed.ncbi.nlm.nih.gov/36267860/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,34513887,From Clinical Diagnosis to the Discovery of Multigene Rare Sequence Variants in Pseudoxanthoma elasticum: A Case Report.,2021,10.3389/fmed.2021.726856,https://pubmed.ncbi.nlm.nih.gov/34513887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AGBL5,ENSG00000084693,Unsafe,28812028,Expression Profile of Genes Potentially Associated with Adequate Glycemic Control in Patients with Type 2 Diabetes Mellitus.,2017,10.1155/2017/2180819,https://pubmed.ncbi.nlm.nih.gov/28812028/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,42231458,ELYS promotes hepatocellular carcinoma stemness by activating a FOXO6-NUP205 transcriptional module downstream of PI3K/AKT to drive Hedgehog signaling.,2026,10.1186/s13578-026-01595-y,https://pubmed.ncbi.nlm.nih.gov/42231458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,40707755,AHCTF1 Functions as an Oncogenic Factor and Promotes Tumor Progression in Hepatocellular Carcinoma.,2025,10.1007/s10620-025-09187-5,https://pubmed.ncbi.nlm.nih.gov/40707755/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,40359232,The Drosophila nucleoporin ELYS is required for parental chromosome arrangement at fertilization.,2025,10.1093/g3journal/jkaf104,https://pubmed.ncbi.nlm.nih.gov/40359232/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,36648336,ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma.,2023,10.7554/elife.73407,https://pubmed.ncbi.nlm.nih.gov/36648336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,42081506,Development of predictive models for the prognosis of triple-negative breast cancer using multiple transcriptomic analyses.,2026,10.1371/journal.pone.0348414,https://pubmed.ncbi.nlm.nih.gov/42081506/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,38951619,Nucleoporin Elys attaches peripheral chromatin to the nuclear pores in interphase nuclei.,2024,10.1038/s42003-024-06495-w,https://pubmed.ncbi.nlm.nih.gov/38951619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,41551196,Engineered LINC MIR503HG-loaded extracellular vesicles maintain stemness and pluripotency during long-term hiPSCs culture.,2026,10.1016/j.bioactmat.2025.12.023,https://pubmed.ncbi.nlm.nih.gov/41551196/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,41174229,In situ architecture of the nuclear pore complex of the higher plant Arabidopsis thaliana.,2025,10.1038/s41477-025-02138-y,https://pubmed.ncbi.nlm.nih.gov/41174229/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,38605278,Phosphorylation of ELYS promotes its interaction with VAPB at decondensing chromosomes during mitosis.,2024,10.1038/s44319-024-00125-6,https://pubmed.ncbi.nlm.nih.gov/38605278/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,39353426,Regulation of outer kinetochore assembly during meiosis I and II by CENP-A and KNL-2/M18BP1 in C. elegans oocytes.,2024,10.1016/j.cub.2024.09.004,https://pubmed.ncbi.nlm.nih.gov/39353426/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,36493774,Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation.,2022,10.1016/j.cell.2022.11.011,https://pubmed.ncbi.nlm.nih.gov/36493774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,35017527,Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site.,2022,10.1038/s41467-021-27868-3,https://pubmed.ncbi.nlm.nih.gov/35017527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,31069272,Structural and biochemical analyses of the nuclear pore complex component ELYS identify residues responsible for nucleosome binding.,2019,10.1038/s42003-019-0385-7,https://pubmed.ncbi.nlm.nih.gov/31069272/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,31784729,WNT signaling and AHCTF1 promote oncogenic MYC expression through super-enhancer-mediated gene gating.,2019,10.1038/s41588-019-0535-3,https://pubmed.ncbi.nlm.nih.gov/31784729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,33322130,The Role of Nucleoporin Elys in Nuclear Pore Complex Assembly and Regulation of Genome Architecture.,2020,10.3390/ijms21249475,https://pubmed.ncbi.nlm.nih.gov/33322130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,36351393,Nucleoporins facilitate ORC loading onto chromatin.,2022,10.1016/j.celrep.2022.111590,https://pubmed.ncbi.nlm.nih.gov/36351393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,31941789,Drosophila ELYS regulates Dorsal dynamics during development.,2020,10.1074/jbc.ra119.009451,https://pubmed.ncbi.nlm.nih.gov/31941789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,34723143,Mutations linked to loss of cell cycle control can render cells responsive to local differentiation cues.,2021,10.17912/micropub.biology.000481,https://pubmed.ncbi.nlm.nih.gov/34723143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,34874453,Reticulon-like REEP4 at the inner nuclear membrane promotes nuclear pore complex formation.,2022,10.1083/jcb.202101049,https://pubmed.ncbi.nlm.nih.gov/34874453/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHCTF1,ENSG00000153207,Unsafe,27802161,ELYS regulates the localization of LBR by modulating its phosphorylation state.,2016,10.1242/jcs.190678,https://pubmed.ncbi.nlm.nih.gov/27802161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,42458531,Esophageal epithelial cell-derived kynurenine drives Th17 inflammation in reflux esophagitis and is targeted by Xuanfu Daizhe decoction.,2026,10.1186/s13020-026-01413-0,https://pubmed.ncbi.nlm.nih.gov/42458531/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,42610671,Cytodiagnostic features of angiofibroma of soft tissue: A review of 16 cases to identify characteristic findings and their diagnostic significance.,2026,10.1002/cncy.70142,https://pubmed.ncbi.nlm.nih.gov/42610671/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,41521457,Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages.,2026,10.1002/advs.202516704,https://pubmed.ncbi.nlm.nih.gov/41521457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,42317867,Folate deficiency correlates with severity of primary biliary cholangitis via modulating key regulatory genes.,2026,10.3389/fnut.2026.1838352,https://pubmed.ncbi.nlm.nih.gov/42317867/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,42825885,Urban PM&lt;sub&gt;0.2&lt;/sub&gt; Affects Astrocytes by Inducing Xenobiotic and Oxidative Stress Responses.,2026,10.1007/s12035-026-06232-w,https://pubmed.ncbi.nlm.nih.gov/42825885/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,42792976,Two Separable Aging Domains in Blood DNA Methylation Scores Developed for Cancer Research: Mitotic Replication and Early-Life Systemic Dysregulation.,2026,10.3390/genes17091083,https://pubmed.ncbi.nlm.nih.gov/42792976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,40836245,Germline structural variations involving the pediatric brain tumor transcriptome include disease-relevant and ancestry-related genes.,2025,10.1186/s40478-025-02098-6,https://pubmed.ncbi.nlm.nih.gov/40836245/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,42073597,"Molecular Links Between Smoking, COPD, and Lung Cancer: A DNA Methylation Perspective.",2026,10.3390/cancers18081273,https://pubmed.ncbi.nlm.nih.gov/42073597/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,39030724,The enigmatic AHRR: beyond aryl hydrocarbon receptor repression.,2024,10.1093/jleuko/qiae163,https://pubmed.ncbi.nlm.nih.gov/39030724/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,42414885,Polyunsaturated fatty acids modulation of smoking-related epigenetics and pulmonary outcomes.,2026,10.1186/s12263-026-00812-0,https://pubmed.ncbi.nlm.nih.gov/42414885/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,42645425,Correlation of AHR Activation-Induced Suppression of PWM-Stimulated IgG and IgG-Triggered Signaling in Human PBMCs.,2026,10.3390/antib15040068,https://pubmed.ncbi.nlm.nih.gov/42645425/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,41781171,E-cigarette exposure impairs skeletal muscle mitochondrial function in male mice.,2026,10.14814/phy2.70797,https://pubmed.ncbi.nlm.nih.gov/41781171/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,42380929,Impact of tobacco smoking on estimated telomere shortening and epigenetic age acceleration among human blood immune cell types.,2026,10.1186/s13148-026-02187-w,https://pubmed.ncbi.nlm.nih.gov/42380929/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,38701199,The AHR repressor limits expression of antimicrobial genes but not AHR-dependent genes in intestinal eosinophils.,2024,10.1093/jleuko/qiae105,https://pubmed.ncbi.nlm.nih.gov/38701199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,41181152,Integrating bioinformatics and molecular experiments to reveal the critical role of the cellular energy metabolism-related marker PLA2G1B in COPD epithelial cells.,2025,10.3389/fimmu.2025.1666195,https://pubmed.ncbi.nlm.nih.gov/41181152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,42506718,Effect of Dietary Aryl Hydrocarbon Receptor Ligands on Indoxyl Sulfate-Induced Endothelial Activation.,2026,10.3390/toxins18070298,https://pubmed.ncbi.nlm.nih.gov/42506718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,38142533,Silencing of aryl hydrocarbon receptor repressor restrains Th17 cell immunity in autoimmune hepatitis.,2024,10.1016/j.jaut.2023.103162,https://pubmed.ncbi.nlm.nih.gov/38142533/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,38490207,The association of cigarette smoking with DNA methylation and gene expression in human tissue samples.,2024,10.1016/j.ajhg.2024.02.012,https://pubmed.ncbi.nlm.nih.gov/38490207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,38361045,AHRR and SFRP2 in primary versus recurrent high-grade serous ovarian carcinoma and their prognostic implication.,2024,10.1038/s41416-023-02550-1,https://pubmed.ncbi.nlm.nih.gov/38361045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,38821174,Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis.,2024,10.1016/j.molmet.2024.101963,https://pubmed.ncbi.nlm.nih.gov/38821174/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,42379639,Ambient fine particulate matter (PM2.5) induces AhR-dependent proinflammatory responses and reactive oxygen species production in human conjunctival epithelial cells.,2026,10.1080/15569527.2026.2695393,https://pubmed.ncbi.nlm.nih.gov/42379639/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,41003523,Short-Term Effects of Dietary Selenomethionine Supplementation on Hepatic and Renal Transcriptomic Alterations Induced by Ochratoxin a in Broiler Chickens.,2025,10.3390/toxins17090460,https://pubmed.ncbi.nlm.nih.gov/41003523/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,41578841,"A Nationwide Danish Comparative Effectiveness Study of GLP-1 RA, SGLT2i and DPP-4i Treatment on Risk of Stroke, Myocardial Infarction and Mortality in Type 2 Diabetes.",2026,10.1002/edm2.70165,https://pubmed.ncbi.nlm.nih.gov/41578841/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,40036688,"How many doses and what type of antibiotic should be used as systemic antibiotic prophylaxis in primary hip and knee arthroplasty? A register-based study on 301,204 primary total and hemi- hip and total knee arthroplasties in Norway 2005-2023.",2025,10.2340/17453674.2025.43003,https://pubmed.ncbi.nlm.nih.gov/40036688/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,40753956,"Examining the timing of trauma, PTSD onset, and DNA methylation: A multicohort investigation of candidate CpG sites.",2025,10.1016/j.jpsychires.2025.07.026,https://pubmed.ncbi.nlm.nih.gov/40753956/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,38805178,Chronotropic Incompetence Among People With HIV Improves With Exercise Training in the Exercise for Healthy Aging Study.,2024,10.1093/infdis/jiae284,https://pubmed.ncbi.nlm.nih.gov/38805178/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,40062740,Selective serotonin reuptake inhibitors and osteoporosis: a target trial emulation using real-world data.,2025,10.1017/neu.2025.3,https://pubmed.ncbi.nlm.nih.gov/40062740/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,40441662,Epigenetic predictor of smoking status in buccal cells.,2025,10.1016/j.taap.2025.117415,https://pubmed.ncbi.nlm.nih.gov/40441662/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,39164771,Exposure-associated DNA methylation among people exposed to multiple industrial pollutants.,2024,10.1186/s13148-024-01705-y,https://pubmed.ncbi.nlm.nih.gov/39164771/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,41446364,Considerations for study design and analysis for ethically and culturally safe DNA methylation research in Aotearoa New Zealand.,2026,10.1016/j.ssmph.2025.101889,https://pubmed.ncbi.nlm.nih.gov/41446364/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,38092155,Multi-Fusarium mycotoxin exposure activates Nrf2 and Ahr pathway in the liver of laying hens.,2024,10.1016/j.toxlet.2023.12.006,https://pubmed.ncbi.nlm.nih.gov/38092155/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,19380484,"The active form of human aryl hydrocarbon receptor (AHR) repressor lacks exon 8, and its Pro 185 and Ala 185 variants repress both AHR and hypoxia-inducible factor.",2009,10.1128/mcb.00206-09,https://pubmed.ncbi.nlm.nih.gov/19380484/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,18172554,The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers.,2008,10.1172/jci30024,https://pubmed.ncbi.nlm.nih.gov/18172554/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,14672759,Characteristic expression of aryl hydrocarbon receptor repressor gene in human tissues: organ-specific distribution and variable induction patterns in mononuclear cells.,2004,10.1016/j.lfs.2003.07.022,https://pubmed.ncbi.nlm.nih.gov/14672759/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AHRR,ENSG00000063438,Unsafe,11835227,Characterization of the aryl hydrocarbon receptor repressor gene and association of its Pro185Ala polymorphism with micropenis.,2002,10.1002/tera.1093,https://pubmed.ncbi.nlm.nih.gov/11835227/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,41465493,Restoring Sight: The Journey of AIPL1 from Discovery to Therapy.,2025,10.3390/ijms262412066,https://pubmed.ncbi.nlm.nih.gov/41465493/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,41096698,Computational Evidence for Digenic Contribution of &lt;i&gt;AIPL1&lt;/i&gt; and &lt;i&gt;BBS2&lt;/i&gt; Rare Variants in Inherited Retinal Dystrophy.,2025,10.3390/ijms26199430,https://pubmed.ncbi.nlm.nih.gov/41096698/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,42339074,Redox regulation of PDE6 and cGMP signaling in diabetic retinal neurodegeneration.,2026,10.1016/j.bbrep.2026.102670,https://pubmed.ncbi.nlm.nih.gov/42339074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,41404501,Adenine base editor correction of pathogenic variations associated with inherited retinal dystrophy in patient iPSC and retinal organoids.,2025,10.1016/j.omtn.2025.102777,https://pubmed.ncbi.nlm.nih.gov/41404501/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,39182365,Low cytoplasmic NUB1 protein exerts hypoxic cell death with poorer prognosis in oestrogen receptor negative breast cancer patients.,2024,10.1016/j.tranon.2024.102106,https://pubmed.ncbi.nlm.nih.gov/39182365/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,40154478,Human cone photoreceptor transplantation stimulates remodeling and restores function in AIPL1 model of end-stage Leber congenital amaurosis.,2025,10.1016/j.stemcr.2025.102470,https://pubmed.ncbi.nlm.nih.gov/40154478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,38439910,Effective AAV-mediated gene replacement therapy in retinal organoids modeling AIPL1-associated LCA4.,2024,10.1016/j.omtn.2024.102148,https://pubmed.ncbi.nlm.nih.gov/38439910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,39806458,Phosphatidylinositol promoted the proliferation and invasion of pituitary adenoma cells by regulating POU1F1 expression.,2025,10.1186/s40170-024-00372-0,https://pubmed.ncbi.nlm.nih.gov/39806458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,41344850,Analysis of gene mutation spectrum for early-onset high myopia based on whole-exome sequencing.,2026,10.1136/bjo-2025-327552,https://pubmed.ncbi.nlm.nih.gov/41344850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,37812058,"Correction to: ""Gene therapy for retinitis pigmentosa and Leber congenital amaurosis caused by defects in AIPL1: effective rescue of mouse models of partial and complete Aipl1 deficiency using AAV2/2 and AAV2/8 vectors"".",2023,10.1093/hmg/ddad169,https://pubmed.ncbi.nlm.nih.gov/37812058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,38569559,Correction to: Gene therapy for retinitis pigmentosa and Leber congenital amaurosis caused by defects in AIPL1: effective rescue of mouse models of partial and complete Aipl1 deficiency using AAV2/2 and AAV2/8 vectors.,2024,10.1093/hmg/ddae053,https://pubmed.ncbi.nlm.nih.gov/38569559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,39733410,The G Protein-Coupled Receptor-Related Gene Signatures for Diagnosis and Prognosis in Glioblastoma: A Deep Learning Model Using RNA-Seq Data.,2024,10.31557/apjcp.2024.25.12.4201,https://pubmed.ncbi.nlm.nih.gov/39733410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,38203368,RNA-Seq Analysis of Trans-Differentiated ARPE-19 Cells Transduced by AAV9-AIPL1 Vectors.,2023,10.3390/ijms25010197,https://pubmed.ncbi.nlm.nih.gov/38203368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,36982987,Retinal Organoids from an AIPL1 CRISPR/Cas9 Knockout Cell Line Successfully Recapitulate the Molecular Features of LCA4 Disease.,2023,10.3390/ijms24065912,https://pubmed.ncbi.nlm.nih.gov/36982987/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,40141357,Deciphering the Genetic Basis of Degenerative and Developmental Eye Disorders in 50 Pakistani Consanguineous Families Using Whole-Exome Sequencing.,2025,10.3390/ijms26062715,https://pubmed.ncbi.nlm.nih.gov/40141357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,38110033,Reconstitution of the phosphodiesterase 6 maturation process important for photoreceptor cell function.,2024,10.1016/j.jbc.2023.105576,https://pubmed.ncbi.nlm.nih.gov/38110033/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,39532089,Loss of paired immunoglobin-like type 2 receptor B gene associated with age-related macular degeneration impairs photoreceptor function in mouse retina.,2025,10.1093/hmg/ddae161,https://pubmed.ncbi.nlm.nih.gov/39532089/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,35065964,Molecular insights into the maturation of phosphodiesterase 6 by the specialized chaperone complex of HSP90 with AIPL1.,2022,10.1016/j.jbc.2022.101620,https://pubmed.ncbi.nlm.nih.gov/35065964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,36657440,Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1.,2023,10.1016/j.str.2022.12.014,https://pubmed.ncbi.nlm.nih.gov/36657440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,36084639,Investigation of PTC124-mediated translational readthrough in a retinal organoid model of AIPL1-associated Leber congenital amaurosis.,2022,10.1016/j.stemcr.2022.08.005,https://pubmed.ncbi.nlm.nih.gov/36084639/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,42537978,"Efficacy, Safety, and Durability of Gene Therapy for Inherited Retinal Diseases in the Pediatric Population: A Scoping Review.",2026,10.1016/j.ajo.2026.07.039,https://pubmed.ncbi.nlm.nih.gov/42537978/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,39986747,"Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study.",2025,10.1016/s0140-6736(24)02812-5,https://pubmed.ncbi.nlm.nih.gov/39986747/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,31884595,Gene and Cell Therapy for AIPL1-Associated Leber Congenital Amaurosis: Challenges and Prospects.,2019,10.1007/978-3-030-27378-1_16,https://pubmed.ncbi.nlm.nih.gov/31884595/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,33928237,Retinal imaging in inherited retinal diseases.,2020,10.21037/aes-20-81,https://pubmed.ncbi.nlm.nih.gov/33928237/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,26015512,Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy.,2015,10.1158/1078-0432.ccr-15-0133,https://pubmed.ncbi.nlm.nih.gov/26015512/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,21474771,Evaluation of Italian patients with leber congenital amaurosis due to AIPL1 mutations highlights the potential applicability of gene therapy.,2011,10.1167/iovs.10-6543,https://pubmed.ncbi.nlm.nih.gov/21474771/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,22412862,"Leber congenital amaurosis associated with AIPL1: challenges in ascribing disease causation, clinical findings, and implications for gene therapy.",2012,10.1371/journal.pone.0032330,https://pubmed.ncbi.nlm.nih.gov/22412862/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,21880665,Gene therapy using self-complementary Y733F capsid mutant AAV2/8 restores vision in a model of early onset Leber congenital amaurosis.,2011,10.1093/hmg/ddr391,https://pubmed.ncbi.nlm.nih.gov/21880665/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,19710705,Gene therapy with a promoter targeting both rods and cones rescues retinal degeneration caused by AIPL1 mutations.,2010,10.1038/gt.2009.104,https://pubmed.ncbi.nlm.nih.gov/19710705/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,22784109,NeuroD1 is required for survival of photoreceptors but not pinealocytes: results from targeted gene deletion studies.,2012,10.1111/j.1471-4159.2012.07870.x,https://pubmed.ncbi.nlm.nih.gov/22784109/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,25775262,Homozygosity mapping and targeted sanger sequencing reveal genetic defects underlying inherited retinal disease in families from pakistan.,2015,10.1371/journal.pone.0119806,https://pubmed.ncbi.nlm.nih.gov/25775262/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,26626312,Comprehensive genotyping reveals RPE65 as the most frequently mutated gene in Leber congenital amaurosis in Denmark.,2016,10.1038/ejhg.2015.241,https://pubmed.ncbi.nlm.nih.gov/26626312/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,19840725,Which Leber congenital amaurosis patients are eligible for gene therapy trials?,2009,10.1016/j.jaapos.2009.08.006,https://pubmed.ncbi.nlm.nih.gov/19840725/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AIPL1,ENSG00000129221,Unsafe,12374762,The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1.,2002,10.1093/hmg/11.22.2723,https://pubmed.ncbi.nlm.nih.gov/12374762/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,42768120,Upregulation of AK7 in ACC-VTA glutamatergic projections contributes to chronic inflammation pain in male mice.,2026,10.1038/s44319-026-00940-z,https://pubmed.ncbi.nlm.nih.gov/42768120/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,40381709,Centriolar defects underlie a primary ciliary dyskinesia phenotype in an adenylate kinase 7 deficient ciliated epithelium.,2025,10.1016/j.ydbio.2025.05.011,https://pubmed.ncbi.nlm.nih.gov/40381709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,38970774,AK7-deficiency reversal inhibits ccRCC progression and boosts anti-PD1 immunotherapy sensitivity.,2024,10.18632/aging.206006,https://pubmed.ncbi.nlm.nih.gov/38970774/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,39569727,Attenuation of Ampullary Anoctamin 1 by the peritoneal fluid in rhesus macaques with spontaneous endometriosis†.,2025,10.1093/biolre/ioae173,https://pubmed.ncbi.nlm.nih.gov/39569727/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,41207351,Chronic high-salt diet induces cognitive impairment and anxiety through gut microbiota alterations.,2025,10.1016/j.ejphar.2025.178350,https://pubmed.ncbi.nlm.nih.gov/41207351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,39254435,A novel homozygous splicing mutation in AK7 causes multiple morphological abnormalities of sperm flagella in patients from consanguineous Pakistani families.,2025,10.4103/aja202471,https://pubmed.ncbi.nlm.nih.gov/39254435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,40764403,A novel cuproptosis-related genes nomogram on the prognosis and immune microenvironment of breast invasive carcinoma.,2025,10.1038/s41598-025-14621-9,https://pubmed.ncbi.nlm.nih.gov/40764403/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,40759314,Inhibition of Sirtuin 2 enhances autophagy and restores neuronal function in aged hippocampal neurons.,2025,10.1016/j.brainresbull.2025.111501,https://pubmed.ncbi.nlm.nih.gov/40759314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,42710154,Integrative transcriptomic identification of potential common biomarkers between non-obstructive azoospermia and papillary thyroid cancer via multi-algorithmic machine learning and network biology approaches.,2026,10.1016/j.ctarc.2026.101434,https://pubmed.ncbi.nlm.nih.gov/42710154/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,39285691,A novel homozygous splicing mutation in AK7 associated with multiple morphological abnormalities of the sperm flagella.,2025,10.4103/aja202479,https://pubmed.ncbi.nlm.nih.gov/39285691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,38497118,A first complete catalog of highly expressed genes in eight chicken tissues reveals uncharacterized gene families specific for the chicken testis.,2024,10.1152/physiolgenomics.00151.2023,https://pubmed.ncbi.nlm.nih.gov/38497118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,41674972,A novel prognostic model for colon adenocarcinoma based on cofactor and vitamin metabolism-related genes.,2026,10.21037/tcr-2025-1521,https://pubmed.ncbi.nlm.nih.gov/41674972/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,40376536,Establishment and clinical significance of genetic factor screening method for patients with nonobstructive azoospermia based on whole exon sequencing technology.,2025,10.21037/tau-2024-676,https://pubmed.ncbi.nlm.nih.gov/40376536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,34854019,A novel homozygous missense mutation in AK7 causes multiple morphological anomalies of the flagella and oligoasthenoteratozoospermia.,2022,10.1007/s10815-021-02363-2,https://pubmed.ncbi.nlm.nih.gov/34854019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,38247802,High Stretch Modulates cAMP/ATP Level in Association with Purine Metabolism via miRNA-mRNA Interactions in Cultured Human Airway Smooth Muscle Cells.,2024,10.3390/cells13020110,https://pubmed.ncbi.nlm.nih.gov/38247802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,33429787,Adenylate kinase 7 is a prognostic indicator of overall survival in ovarian cancer.,2021,10.1097/md.0000000000024134,https://pubmed.ncbi.nlm.nih.gov/33429787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,40579595,Mouse radial spoke 3 is a metabolic and regulatory hub in cilia.,2025,10.1038/s41594-025-01594-6,https://pubmed.ncbi.nlm.nih.gov/40579595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,36512053,Novel mannich-based derivative of 2-mercaptobenzimidazole (AK7): a new candidate for the treatment of inflammatory arthritis owing to its NF-κB1 inhibitory potential.,2023,10.1007/s00210-022-02359-4,https://pubmed.ncbi.nlm.nih.gov/36512053/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,36401332,A circular network of purine metabolism as coregulators of dilated cardiomyopathy.,2022,10.1186/s12967-022-03739-3,https://pubmed.ncbi.nlm.nih.gov/36401332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,34768716,IRF3 Knockout Results in Partial or Complete Rejection of Murine Mesothelioma.,2021,10.3390/jcm10215196,https://pubmed.ncbi.nlm.nih.gov/34768716/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,31713761,Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation.,2020,10.1007/s10571-019-00746-9,https://pubmed.ncbi.nlm.nih.gov/31713761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,32782434,Evaluation of the upregulation and surface expression of hypoxanthine guanine phosphoribosyltransferase in acute lymphoblastic leukemia and Burkitt's B cell lymphoma.,2020,10.1186/s12935-020-01457-8,https://pubmed.ncbi.nlm.nih.gov/32782434/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,29365104,Homozygous missense mutation L673P in adenylate kinase 7 (AK7) leads to primary male infertility and multiple morphological anomalies of the flagella but not to primary ciliary dyskinesia.,2018,10.1093/hmg/ddy034,https://pubmed.ncbi.nlm.nih.gov/29365104/,annotation citations | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,25608039,The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.,2015,10.1371/journal.pone.0116919,https://pubmed.ncbi.nlm.nih.gov/25608039/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,26763390,MEIS3 is repressed in A549 lung epithelial cells by deoxynivalenol and the repression contributes to the deleterious effect.,2016,10.2131/jts.41.25,https://pubmed.ncbi.nlm.nih.gov/26763390/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,21619908,Vaccination with epigenetically treated mesothelioma cells induces immunisation and blocks tumour growth.,2011,10.1016/j.vaccine.2011.05.029,https://pubmed.ncbi.nlm.nih.gov/21619908/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,34529793,"Genetic diagnosis, sperm phenotype and ICSI outcome in case of severe asthenozoospermia with multiple morphological abnormalities of the flagellum.",2021,10.1093/humrep/deab200,https://pubmed.ncbi.nlm.nih.gov/34529793/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,18765425,Autoreactive B-cell elimination by pathogenic IgG specific for the same antigen: implications for peripheral tolerance.,2008,10.1093/intimm/dxn095,https://pubmed.ncbi.nlm.nih.gov/18765425/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,26732106,Proteomic signatures of infertile men with clinical varicocele and their validation studies reveal mitochondrial dysfunction leading to infertility.,2016,10.4103/1008-682x.170445,https://pubmed.ncbi.nlm.nih.gov/26732106/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,17122405,"Diversity of Archaea in marine sediments from Skan Bay, Alaska, including cultivated methanogens, and description of Methanogenium boonei sp. nov.",2007,10.1128/aem.01154-06,https://pubmed.ncbi.nlm.nih.gov/17122405/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,10590110,Integrins alpha2beta1 and alpha4beta1 can mediate SA11 rotavirus attachment and entry into cells.,2000,10.1128/jvi.74.1.228-236.2000,https://pubmed.ncbi.nlm.nih.gov/10590110/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK7,ENSG00000140057,Unsafe,3052298,Influence of unsaturated fatty acid membrane component on sensitivity of an Escherichia coli fatty acid auxotroph to conditions of nutrient depletion.,1988,10.1128/aem.54.8.2107-2111.1988,https://pubmed.ncbi.nlm.nih.gov/3052298/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK8,ENSG00000165695,Unsafe,42089676,AK8 deficiency causes primary ciliary dyskinesia by disrupting energy homeostasis in the airways.,2026,10.1093/ajrccm/aamag214,https://pubmed.ncbi.nlm.nih.gov/42089676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK8,ENSG00000165695,Unsafe,41055978,EFCAB10 anchors AK8 to the radial spoke for proper ciliary motility.,2025,10.1073/pnas.2510243122,https://pubmed.ncbi.nlm.nih.gov/41055978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK8,ENSG00000165695,Unsafe,41043331,Guipi Tang alleviates vascular dementia by regulating purine metabolism via gut microbiota-derived pantothenic acid.,2025,10.1016/j.phymed.2025.157297,https://pubmed.ncbi.nlm.nih.gov/41043331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK8,ENSG00000165695,Unsafe,39849482,IQUB mutation induces radial spoke 1 deficiency causing asthenozoospermia with normal sperm morphology in humans and mice.,2025,10.1186/s12964-025-02043-z,https://pubmed.ncbi.nlm.nih.gov/39849482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK8,ENSG00000165695,Unsafe,38761355,Adenylate kinase phosphate energy shuttle underlies energetic communication in flagellar axonemes.,2024,10.1007/s11427-023-2539-1,https://pubmed.ncbi.nlm.nih.gov/38761355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK8,ENSG00000165695,Unsafe,33139725,CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module.,2020,10.1038/s41467-020-19113-0,https://pubmed.ncbi.nlm.nih.gov/33139725/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK8,ENSG00000165695,Unsafe,38051303,"Genetic Factors and Long-term Treatment-Related Neurocognitive Deficits, Anxiety, and Depression in Childhood Leukemia Survivors: An Exome-Wide Association Study.",2024,10.1158/1055-9965.epi-23-0634,https://pubmed.ncbi.nlm.nih.gov/38051303/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK8,ENSG00000165695,Unsafe,33067958,[Identify the Molecular Target of Diffuse Large B Cell Lymphoma by Bioinformatics Analysis].,2020,10.19746/j.cnki.issn.1009-2137.2020.05.026,https://pubmed.ncbi.nlm.nih.gov/33067958/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK8,ENSG00000165695,Unsafe,33905082,Co-expression Analysis of Genes and Tumor-Infiltrating Immune Cells in Metastatic Uterine Carcinosarcoma.,2021,10.1007/s43032-021-00584-5,https://pubmed.ncbi.nlm.nih.gov/33905082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK8,ENSG00000165695,Unsafe,21080915,The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes.,2011,10.1042/bj20101443,https://pubmed.ncbi.nlm.nih.gov/21080915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK8,ENSG00000165695,Unsafe,24740601,Adenine nucleotide metabolism and a role for AMP in modulating flagellar waveforms in mouse sperm.,2014,10.1095/biolreprod.113.114447,https://pubmed.ncbi.nlm.nih.gov/24740601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK8,ENSG00000165695,Unsafe,30397022,Healthy Roots and Leaves: Comparative Genome Structure of Horseradish and Watercress.,2019,10.1104/pp.18.01165,https://pubmed.ncbi.nlm.nih.gov/30397022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK8,ENSG00000165695,Unsafe,15712601,Characterization of a murine anti-laminin-1 monoclonal antibody (AK8) produced by immunization with mouse-derived laminin-1.,2005,10.1080/17402520400014168,https://pubmed.ncbi.nlm.nih.gov/15712601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK8,ENSG00000165695,Unsafe,21746835,Congenital hydrocephalus in genetically engineered mice.,2012,10.1177/0300985811415708,https://pubmed.ncbi.nlm.nih.gov/21746835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK8,ENSG00000165695,Unsafe,19597321,"Glycosaminoglycan degradation-inhibitory lactic acid bacteria ameliorate 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice.",2009,10.4014/jmb.0808.479,https://pubmed.ncbi.nlm.nih.gov/19597321/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK8,ENSG00000165695,Unsafe,28487430,RNA-Dependent Cysteine Biosynthesis in Bacteria and Archaea.,2017,10.1128/mbio.00561-17,https://pubmed.ncbi.nlm.nih.gov/28487430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK8,ENSG00000165695,Unsafe,8056032,T cells which do not express membrane tumor necrosis factor-alpha activate macrophage effector function by cell contact-dependent signaling of macrophage tumor necrosis factor-alpha production.,1994,10.1002/eji.1830240803,https://pubmed.ncbi.nlm.nih.gov/8056032/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,38100419,A role for mutations in &lt;i&gt;AK9&lt;/i&gt; and other genes affecting ependymal cells in idiopathic normal pressure hydrocephalus.,2023,10.1073/pnas.2300681120,https://pubmed.ncbi.nlm.nih.gov/38100419/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,37812723,Adenylate kinase 9 is essential for sperm function and male fertility in mammals.,2023,10.1073/pnas.2305712120,https://pubmed.ncbi.nlm.nih.gov/37812723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,37713809,Deficiency in AK9 causes asthenozoospermia and male infertility by destabilising sperm nucleotide homeostasis.,2023,10.1016/j.ebiom.2023.104798,https://pubmed.ncbi.nlm.nih.gov/37713809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,41550485,Unveiling the synergistic enhancement of cefotaxime efficacy with magnetic iron nanoparticles using co-culture technique and tooth model: a promising approach to combat antibiotic resistance.,2026,10.1007/s13205-025-04690-y,https://pubmed.ncbi.nlm.nih.gov/41550485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,42112556,Identifying Candidate Genes for Late-Feathering Subtypes of the Shouguang Chicken by Genome-Wide Association Study and Differential Expression Analysis.,2026,10.1002/age.70115,https://pubmed.ncbi.nlm.nih.gov/42112556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,38657135,Gamma irradiation in modulating arsenic bioremediation potential of &lt;i&gt;Pseudomonas&lt;/i&gt; sp. AK1 and AK9.,2024,10.1080/09553002.2024.2345137,https://pubmed.ncbi.nlm.nih.gov/38657135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,40266017,Genetic Risk Factors in Normal Pressure Hydrocephalus: What We Know and What Is Next.,2025,10.1002/mds.30206,https://pubmed.ncbi.nlm.nih.gov/40266017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,38761355,Adenylate kinase phosphate energy shuttle underlies energetic communication in flagellar axonemes.,2024,10.1007/s11427-023-2539-1,https://pubmed.ncbi.nlm.nih.gov/38761355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,38051288,Integrative analyses of N6-methyladenosine-associated single-nucleotide polymorphisms (m6A-SNPs) identify tumor suppressor gene AK9 in lung cancer.,2024,10.1002/mc.23669,https://pubmed.ncbi.nlm.nih.gov/38051288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,39747316,Utilizing integrated bioinformatics and machine learning approaches to elucidate biomarkers linking sepsis to purine metabolism-associated genes.,2025,10.1038/s41598-024-82998-0,https://pubmed.ncbi.nlm.nih.gov/39747316/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,36191825,Cloning and functional characterization of arsenite oxidase (aoxB) gene associated with arsenic transformation in Pseudomonas sp. strain AK9.,2023,10.1016/j.gene.2022.146926,https://pubmed.ncbi.nlm.nih.gov/36191825/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,36512053,Novel mannich-based derivative of 2-mercaptobenzimidazole (AK7): a new candidate for the treatment of inflammatory arthritis owing to its NF-κB1 inhibitory potential.,2023,10.1007/s00210-022-02359-4,https://pubmed.ncbi.nlm.nih.gov/36512053/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,39997915,Integrated Metabolomic and Transcriptomic Analysis Revealed the Mechanism of BHPF Exposure in Endometrium.,2025,10.3390/toxics13020100,https://pubmed.ncbi.nlm.nih.gov/39997915/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,40369207,"Unraveling folate deficiency: prevalence, biochemical associations, genetic determinants, and strategies for adolescent health in North India.",2025,10.1038/s41430-025-01627-9,https://pubmed.ncbi.nlm.nih.gov/40369207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,34028060,Targeted sequencing reveals candidate causal variants for dairy bull subfertility.,2021,10.1111/age.13089,https://pubmed.ncbi.nlm.nih.gov/34028060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,36686818,Alternative splicing event associated with immunological features in bladder cancer.,2022,10.3389/fonc.2022.966088,https://pubmed.ncbi.nlm.nih.gov/36686818/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,27966543,Limb girdle myasthenia with digenic RAPSN and a novel disease gene AK9 mutations.,2017,10.1038/ejhg.2016.162,https://pubmed.ncbi.nlm.nih.gov/27966543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,30046151,Overexpression of Tisochrysis lutea Akd1 identifies a key cold-induced alkenone desaturase enzyme.,2018,10.1038/s41598-018-29482-8,https://pubmed.ncbi.nlm.nih.gov/30046151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,29541605,"Possible bioremediation of arsenic toxicity by isolating indigenous bacteria from the middle Gangetic plain of Bihar, India.",2018,10.1016/j.btre.2018.02.002,https://pubmed.ncbi.nlm.nih.gov/29541605/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,23416111,The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase.,2013,10.1016/j.biocel.2013.02.004,https://pubmed.ncbi.nlm.nih.gov/23416111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,26609109,Hypermutation of DPYD Deregulates Pyrimidine Metabolism and Promotes Malignant Progression.,2016,10.1158/1541-7786.mcr-15-0403,https://pubmed.ncbi.nlm.nih.gov/26609109/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AK9,ENSG00000155085,Unsafe,18765425,Autoreactive B-cell elimination by pathogenic IgG specific for the same antigen: implications for peripheral tolerance.,2008,10.1093/intimm/dxn095,https://pubmed.ncbi.nlm.nih.gov/18765425/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP14,ENSG00000186471,Unsafe,40418986,AKAP14 is dispensable for mouse fertility.,2025,10.1016/j.cdev.2025.204032,https://pubmed.ncbi.nlm.nih.gov/40418986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP14,ENSG00000186471,Unsafe,42537271,Unveiling the molecular basis of gonadal development: Multi-omics uncovers sex-related genes and steroid pathways in Sinonovacula constricta.,2026,10.1016/j.cbd.2026.101953,https://pubmed.ncbi.nlm.nih.gov/42537271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP14,ENSG00000186471,Unsafe,33937989,Differential genetic influences over colorectal cancer risk and gene expression in large bowel mucosa.,2021,10.1002/ijc.33616,https://pubmed.ncbi.nlm.nih.gov/33937989/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP14,ENSG00000186471,Unsafe,12475942,Characterization of an A-kinase anchoring protein in human ciliary axonemes.,2002,10.1091/mbc.e02-07-0391,https://pubmed.ncbi.nlm.nih.gov/12475942/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,42095086,Syncytin-a deficiency compromises murine sperm function by suppressing PRL/PGE2 and PI3K/AKT/mTOR pathway.,2026,10.1016/j.isci.2026.115694,https://pubmed.ncbi.nlm.nih.gov/42095086/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,41516134,NSUN7 Regulates Sperm Flagella Formation at All Stages of Spermiogenesis.,2025,10.3390/ijms27010257,https://pubmed.ncbi.nlm.nih.gov/41516134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,40089458,Core N-DRC components play a crucial role in embryonic development and postnatal organ development.,2025,10.1038/s41419-025-07506-2,https://pubmed.ncbi.nlm.nih.gov/40089458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,39972276,Identification of key genes related to unilateral cryptorchidism in sheep by comprehensive transcriptomics and proteomics analyses.,2025,10.1186/s12864-024-11166-5,https://pubmed.ncbi.nlm.nih.gov/39972276/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,40683100,Development of a novel multi-epitope vaccine against triple-negative breast cancer targeting A-kinase anchoring protein 3 using bioinformatics.,2025,10.1016/j.compbiomed.2025.110757,https://pubmed.ncbi.nlm.nih.gov/40683100/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,40095067,Loss of Cep135 causes oligoasthenoteratozoospermia and male infertility in mice.,2025,10.1007/s00018-025-05616-w,https://pubmed.ncbi.nlm.nih.gov/40095067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,42416903,Alterations in the protein lactylation landscape of sperm from patients with varicocele-associated asthenozoospermia.,2026,10.3389/fendo.2026.1791920,https://pubmed.ncbi.nlm.nih.gov/42416903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,37835834,Characterization of Cancer/Testis Antigens as Prognostic Markers of Ovarian Cancer.,2023,10.3390/diagnostics13193092,https://pubmed.ncbi.nlm.nih.gov/37835834/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,39710003,The testis-specific gene 1700030J22Rikis essential for sperm flagellar function and male fertility in mice.,2025,10.1016/j.jgg.2024.12.010,https://pubmed.ncbi.nlm.nih.gov/39710003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,40898687,CFAP300 loss-of-function variant causes primary ciliary dyskinesia and male infertility via disrupting sperm flagellar assembly and acrosome formation.,2025,10.4103/aja202556,https://pubmed.ncbi.nlm.nih.gov/40898687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,41850444,Benzo[a]pyrene lowers the sperm quality in male rats by downregulating the expression of ZMYND15 and ZMYND10.,2026,10.1016/j.reprotox.2026.109225,https://pubmed.ncbi.nlm.nih.gov/41850444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,35322748,The cancer-testis antigen a-kinase anchor protein 3 facilitates breast cancer progression via activation of the PTEN/PI3K/AKT/mTOR signaling.,2022,10.1080/21655979.2022.2051687,https://pubmed.ncbi.nlm.nih.gov/35322748/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,37146716,STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate Sperm Flagella Assembly in Spermiogenesis.,2023,10.1016/j.mcpro.2023.100564,https://pubmed.ncbi.nlm.nih.gov/37146716/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,36792588,DNALI1 deficiency causes male infertility with severe asthenozoospermia in humans and mice by disrupting the assembly of the flagellar inner dynein arms and fibrous sheath.,2023,10.1038/s41419-023-05653-y,https://pubmed.ncbi.nlm.nih.gov/36792588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,38368523,Evaluation of The 1499T>C Variant in The AKAP3 Gene of Infertile Men with Multiple Morphological Abnormalities of The Sperm Flagella Phenotype: A Case-Control Study.,2024,10.22074/ijfs.2023.561016.1358,https://pubmed.ncbi.nlm.nih.gov/38368523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,40311472,BDE-209 toxicity: From spermiogenesis to sexual maturity in F1 male mice.,2025,10.1016/j.ecoenv.2025.118231,https://pubmed.ncbi.nlm.nih.gov/40311472/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,35256641,Structural modeling of human AKAP3 protein and in silico analysis of single nucleotide polymorphisms associated with sperm motility.,2022,10.1038/s41598-022-07513-9,https://pubmed.ncbi.nlm.nih.gov/35256641/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,41500298,"Myo-Inositol Nano-Emulsion for Enhancing Stallion Chilled Semen: Insights from In Vivo and In Silico Analyses of Sperm Quality, Oxidative Stress, Ultrastructure, Mitochondrial Response, and Semen Bacteriology.",2026,10.1016/j.jevs.2026.105766,https://pubmed.ncbi.nlm.nih.gov/41500298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,35804605,Comparative Proteomic Analyses of Poorly Motile Swamp Buffalo Spermatozoa Reveal Low Energy Metabolism and Deficiencies in Motility-Related Proteins.,2022,10.3390/ani12131706,https://pubmed.ncbi.nlm.nih.gov/35804605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,35663320,The Role of Testosterone in Spermatogenesis: Lessons From Proteome Profiling of Human Spermatozoa in Testosterone Deficiency.,2022,10.3389/fendo.2022.852661,https://pubmed.ncbi.nlm.nih.gov/35663320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,34944009,Protein Kinase A (PRKA) Activity Is Regulated by the Proteasome at the Onset of Human Sperm Capacitation.,2021,10.3390/cells10123501,https://pubmed.ncbi.nlm.nih.gov/34944009/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,32681621,Prediction of 3D Protein Structure Based on The Mutation of AKAP3 and PLOD3 Genes in The Case of Non-Obstructive Azoospermia.,2020,10.22074/ijfs.2020.6028,https://pubmed.ncbi.nlm.nih.gov/32681621/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,32460071,Chronic arsenic exposure lowered sperm motility via impairing ultra-microstructure and key proteins expressions of sperm acrosome and flagellum formation during spermiogenesis in male mice.,2020,10.1016/j.scitotenv.2020.139233,https://pubmed.ncbi.nlm.nih.gov/32460071/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,22941507,Identification of the cancer/testis antigens AKAP3 and CTp11 by SEREX             in hepatocellular carcinoma.,2012,10.3892/or.2012.2002,https://pubmed.ncbi.nlm.nih.gov/22941507/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,23151147,Serological identification of Tektin5 as a cancer/testis antigen and its immunogenicity.,2012,10.1186/1471-2407-12-520,https://pubmed.ncbi.nlm.nih.gov/23151147/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,16929165,Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma.,2006,10.4161/cbt.5.9.3174,https://pubmed.ncbi.nlm.nih.gov/16929165/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,10462507,"Sequences at the 3' side of the c-fos SRE mediate gene expression via an Sob1-dependent, TCF-independent pathway.",1999,10.1006/bbrc.1999.1175,https://pubmed.ncbi.nlm.nih.gov/10462507/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKAP3,ENSG00000111254,Unsafe,10334916,"Cloning and characterization of SOB1, a new testis-specific cDNA encoding a human sperm protein probably involved in oocyte recognition.",1999,10.1006/bbrc.1999.0728,https://pubmed.ncbi.nlm.nih.gov/10334916/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,41192674,Akirin2 regulates IL-6 expression and contributes to immune defense in silver pomfret (Pampus argenteus).,2026,10.1016/j.fsi.2025.110980,https://pubmed.ncbi.nlm.nih.gov/41192674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,41639071,A multivalent adaptor mechanism drives the nuclear import of proteasomes.,2026,10.1038/s41467-026-69162-0,https://pubmed.ncbi.nlm.nih.gov/41639071/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,39267282,Transcranial direct current stimulation enhances the protective effect of isoflurane preconditioning on cerebral ischemia/reperfusion injury: A new mechanism associated with the nuclear protein Akirin2.,2024,10.1111/cns.70033,https://pubmed.ncbi.nlm.nih.gov/39267282/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,39199975,"Identification, Expression, Characteristic Analysis, and Immune Function of Two Akirin Genes in Grass Carp (Ctenopharyngodon idella).",2024,10.3390/ani14162443,https://pubmed.ncbi.nlm.nih.gov/39199975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,35198879,p53-mediated neurodegeneration in the absence of the nuclear protein Akirin2.,2022,10.1016/j.isci.2022.103814,https://pubmed.ncbi.nlm.nih.gov/35198879/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,39733641,Exploring the molecular mechanisms of comorbidity of myocardial infarction and anxiety disorders by combining multiple data sets with in vivo experimental validation.,2025,10.1016/j.intimp.2024.113852,https://pubmed.ncbi.nlm.nih.gov/39733641/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,38685443,Akirin2 enhances antibacterial ability via interacting with 14-3-3ζ in V. splendidus-challenged Apostichopus japonicus.,2024,10.1016/j.fsi.2024.109592,https://pubmed.ncbi.nlm.nih.gov/38685443/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,35589807,Identification of AKIRIN2 as a potential biomarker and correlation with immunotherapy in gastric adenocarcinoma by integrated bioinformatics analysis.,2022,10.1038/s41598-022-12531-8,https://pubmed.ncbi.nlm.nih.gov/35589807/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,39123804,Comparative Transcriptome Analysis of mRNA and miRNA during the Development of Longissimus Dorsi Muscle of Gannan Yak and Tianzhu White Yak.,2024,10.3390/ani14152278,https://pubmed.ncbi.nlm.nih.gov/39123804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,35413928,"miR-203, fine-tunning neuroinflammation by juggling different components of NF-κB signaling.",2022,10.1186/s12974-022-02451-9,https://pubmed.ncbi.nlm.nih.gov/35413928/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,34291801,Function of cofactor Akirin2 in the regulation of gene expression in model human Caucasian neutrophil-like HL60 cells.,2021,10.1042/bsr20211120,https://pubmed.ncbi.nlm.nih.gov/34291801/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,34223621,Function of cofactor Akirin2 in the regulation of gene expression in model human Caucasian neutrophil-like HL60 cells.,2021,10.1042/bcj20210294,https://pubmed.ncbi.nlm.nih.gov/34223621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,37760841,Establishing Molecular Subgroups of CD8+ T Cell-Associated Genes in the Ovarian Cancer Tumour Microenvironment and Predicting the Immunotherapy Response.,2023,10.3390/biomedicines11092399,https://pubmed.ncbi.nlm.nih.gov/37760841/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,30116001,An essential role for the nuclear protein Akirin2 in mouse limb interdigital tissue regression.,2018,10.1038/s41598-018-30801-2,https://pubmed.ncbi.nlm.nih.gov/30116001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,34711951,AKIRIN2 controls the nuclear import of proteasomes in vertebrates.,2021,10.1038/s41586-021-04035-8,https://pubmed.ncbi.nlm.nih.gov/34711951/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,30886152,Akirin2 is modulated by miR-490-3p and facilitates angiogenesis in cholangiocarcinoma through the IL-6/STAT3/VEGFA signaling pathway.,2019,10.1038/s41419-019-1506-4,https://pubmed.ncbi.nlm.nih.gov/30886152/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,32361777,Akirin proteins in development and disease: critical roles and mechanisms of action.,2020,10.1007/s00018-020-03531-w,https://pubmed.ncbi.nlm.nih.gov/32361777/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,27871306,Akirin2 is essential for the formation of the cerebral cortex.,2016,10.1186/s13064-016-0076-8,https://pubmed.ncbi.nlm.nih.gov/27871306/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,35763030,Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease.,2022,10.1007/s00125-022-05735-0,https://pubmed.ncbi.nlm.nih.gov/35763030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,28223540,Akirin2 promotes slow myosin heavy chain expression by CaN/NFATc1 signaling in porcine skeletal muscle satellite cells.,2017,10.18632/oncotarget.15374,https://pubmed.ncbi.nlm.nih.gov/28223540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,34647113,Molecular mechanism of enhancing the immune effect of the Newcastle disease virus vaccine in broilers fed with Bacillus cereus PAS38.,2021,10.1039/d1fo01777b,https://pubmed.ncbi.nlm.nih.gov/34647113/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,30881925,Oral Vaccination With a Formulation Combining Rhipicephalus microplus Subolesin With Heat Inactivated Mycobacterium bovis Reduces Tick Infestations in Cattle.,2019,10.3389/fcimb.2019.00045,https://pubmed.ncbi.nlm.nih.gov/30881925/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,37409633,Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5.,2023,10.15252/embj.2022113348,https://pubmed.ncbi.nlm.nih.gov/37409633/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,26782392,Akirin2 expression in response to vaccine-induced immunity in chicken.,2015,10.4238/2015.december.21.20,https://pubmed.ncbi.nlm.nih.gov/26782392/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,32727237,Involvement of natural killer cells in the pathogenesis of endometriosis in patients with pelvic pain.,2020,10.1177/0300060519871407,https://pubmed.ncbi.nlm.nih.gov/32727237/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,21858694,"Molecular cloning, sequence characterization, and tissue expression analysis of Hi-Line Brown chicken Akirin2.",2011,10.1007/s10930-011-9352-y,https://pubmed.ncbi.nlm.nih.gov/21858694/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKIRIN2,ENSG00000135334,Unsafe,18066067,Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.,2008,10.1038/ni1543,https://pubmed.ncbi.nlm.nih.gov/18066067/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKR1E2,ENSG00000165568,Unsafe,41699263,Hypoxia-induced circ_0017521 enhances glycolysis and promotes NSCLC progression via upregulating the PFKFB3/PI3K-AKT pathway.,2026,10.1007/s00335-026-10202-x,https://pubmed.ncbi.nlm.nih.gov/41699263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKR1E2,ENSG00000165568,Unsafe,40484033,"Inter-individual variability, differential tissue abundance, and sub-cellular localization of human aldo-keto reductases (AKRs) and hydroxy-steroid dehydrogenases (HSDs).",2025,10.1016/j.bcp.2025.117044,https://pubmed.ncbi.nlm.nih.gov/40484033/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKR1E2,ENSG00000165568,Unsafe,40050897,Epigenome-wide analysis reveals potential biomarkers for radiation-induced toxicity risk in prostate cancer.,2025,10.1186/s13148-025-01846-8,https://pubmed.ncbi.nlm.nih.gov/40050897/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKR1E2,ENSG00000165568,Unsafe,30854786,Cancer-testis antigens in canine histiocytic sarcoma and other malignancies.,2019,10.1111/vco.12475,https://pubmed.ncbi.nlm.nih.gov/30854786/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKR1E2,ENSG00000165568,Unsafe,36116349,Whole-transcriptome RNA sequencing reveals the global molecular responses and circRNA/lncRNA-miRNA-mRNA ceRNA regulatory network in chicken fat deposition.,2022,10.1016/j.psj.2022.102121,https://pubmed.ncbi.nlm.nih.gov/36116349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKR1E2,ENSG00000165568,Unsafe,37722844,Quantitative Analysis of mRNA and Protein Expression Levels of Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoforms in the Human Intestine.,2023,10.1124/dmd.123.001402,https://pubmed.ncbi.nlm.nih.gov/37722844/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKR1E2,ENSG00000165568,Unsafe,33036882,Quantitative analysis of mRNA expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in human livers.,2020,10.1016/j.dmpk.2020.08.004,https://pubmed.ncbi.nlm.nih.gov/33036882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKR1E2,ENSG00000165568,Unsafe,32171250,Multiple association analysis of loci and candidate genes that regulate body size at three growth stages in Simmental beef cattle.,2020,10.1186/s12863-020-0837-6,https://pubmed.ncbi.nlm.nih.gov/32171250/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKR1E2,ENSG00000165568,Unsafe,26622071,Phenotypes of Recessive Pediatric Cataract in a Cohort of Children with Identified Homozygous Gene Mutations (An American Ophthalmological Society Thesis).,2015,,https://pubmed.ncbi.nlm.nih.gov/26622071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKR1E2,ENSG00000165568,Unsafe,24239507,Pathways and genes involved in steroid hormone metabolism in male pigs: a review and update.,2014,10.1016/j.jsbmb.2013.11.001,https://pubmed.ncbi.nlm.nih.gov/24239507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKR1E2,ENSG00000165568,Unsafe,16970816,Characterization of the aldo-keto reductase 1C gene cluster on pig chromosome 10: possible associations with reproductive traits.,2006,10.1186/1746-6148-2-28,https://pubmed.ncbi.nlm.nih.gov/16970816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKR1E2,ENSG00000165568,Unsafe,15118078,"Characterization of htAKR, a novel gene product in the aldo-keto reductase family specifically expressed in human testis.",2004,10.1093/molehr/gah062,https://pubmed.ncbi.nlm.nih.gov/15118078/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AKR1E2,ENSG00000165568,Unsafe,12604216,Human testis specific protein: a new member of aldo-keto reductase superfamily.,2003,10.1016/s0009-2797(02)00187-4,https://pubmed.ncbi.nlm.nih.gov/12604216/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,42474621,ALG10 Alleviates IBD-Related Intestinal Fibrosis by Modulating the TGF-β1/PI3K/Akt Signaling Pathway.,2026,10.1007/s10620-026-10132-3,https://pubmed.ncbi.nlm.nih.gov/42474621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,42853272,Clinical and molecular spectrum of congenital disorders of glycosylation in 80 Egyptian patients.,2026,10.1007/s00439-026-02881-y,https://pubmed.ncbi.nlm.nih.gov/42853272/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,35680565,A novel ALG10/TGF-β positive regulatory loop contributes to the stemness of colorectal cancer.,2022,10.18632/aging.204116,https://pubmed.ncbi.nlm.nih.gov/35680565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,39191750,Galectins induced from hemocytes bridge phosphatidylserine and N-glycosylated Drpr/CED-1 receptor during dendrite pruning.,2024,10.1038/s41467-024-51581-6,https://pubmed.ncbi.nlm.nih.gov/39191750/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,36879254,Identification of hub genes and potential molecular mechanisms related to radiotherapy sensitivity in rectal cancer based on multiple datasets.,2023,10.1186/s12967-023-04029-2,https://pubmed.ncbi.nlm.nih.gov/36879254/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,39482899,Genome-Wide Association Study of Temporomandibular Disorder-Related Pain in Finnish Populations.,2025,10.1111/joor.13883,https://pubmed.ncbi.nlm.nih.gov/39482899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,38790878,Mechanistic and Functional Studies on the Microbial Induction of Wolfiporia cocos Liquid Fermentation Products.,2024,10.3390/foods13101578,https://pubmed.ncbi.nlm.nih.gov/38790878/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,33798445,Progressive myoclonus epilepsies-Residual unsolved cases have marked genetic heterogeneity including dolichol-dependent protein glycosylation pathway genes.,2021,10.1016/j.ajhg.2021.03.013,https://pubmed.ncbi.nlm.nih.gov/33798445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,30389790,Abrogation of glucosidase I-mediated glycoprotein deglucosylation results in a sick phenotype in fission yeasts: Model for the human MOGS-CDG disorder.,2018,10.1074/jbc.ra118.004844,https://pubmed.ncbi.nlm.nih.gov/30389790/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,21707802,"Arabidopsis thaliana alpha1,2-glucosyltransferase (ALG10) is required for efficient N-glycosylation and leaf growth.",2011,10.1111/j.1365-313x.2011.04688.x,https://pubmed.ncbi.nlm.nih.gov/21707802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,31569500,Membrane Topological Model of Glycosyltransferases of the GT-C Superfamily.,2019,10.3390/ijms20194842,https://pubmed.ncbi.nlm.nih.gov/31569500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,32103179,Structure and mechanism of the ER-based glucosyltransferase ALG6.,2020,10.1038/s41586-020-2044-z,https://pubmed.ncbi.nlm.nih.gov/32103179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,31996972,Fine mapping and identification of the leaf shape gene BoFL in ornamental kale.,2020,10.1007/s00122-020-03551-x,https://pubmed.ncbi.nlm.nih.gov/31996972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,27094473,SWATH-MS Glycoproteomics Reveals Consequences of Defects in the Glycosylation Machinery.,2016,10.1074/mcp.m115.056366,https://pubmed.ncbi.nlm.nih.gov/27094473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,16041130,Effects of N-glycosylation and inositol on the ER stress response in yeast Saccharomyces cerevisiae.,2005,10.1271/bbb.69.1274,https://pubmed.ncbi.nlm.nih.gov/16041130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,17189275,"HERG is protected from pharmacological block by alpha-1,2-glucosyltransferase function.",2007,10.1074/jbc.m605976200,https://pubmed.ncbi.nlm.nih.gov/17189275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,27263447,Functional proteomic analysis of Ankaferd® Blood Stopper.,2010,10.5152/tjh.2010.03,https://pubmed.ncbi.nlm.nih.gov/27263447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,18552282,Dolichyl-phosphate-glucose is used to make O-glycans on glycoproteins of Trichomonas vaginalis.,2008,10.1128/ec.00061-08,https://pubmed.ncbi.nlm.nih.gov/18552282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,34647356,Global 3'-untranslated region landscape mediated by alternative polyadenylation during meiotic maturation of pig oocytes.,2022,10.1111/rda.14026,https://pubmed.ncbi.nlm.nih.gov/34647356/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10,ENSG00000139133,Unsafe,18855674,Strategy for a genetic assessment of antipsychotic and antidepressant-related proarrhythmia.,2008,10.2174/092986708785909058,https://pubmed.ncbi.nlm.nih.gov/18855674/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,40782342,Biosynthesis of very Long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development.,2025,10.1111/tpj.70396,https://pubmed.ncbi.nlm.nih.gov/40782342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,42607209,Unitary currents through K&lt;sup&gt;+&lt;/sup&gt; selective channelrhodopsins reveal multiple conductance states within an activated state complex.,2026,10.1073/pnas.2604725123,https://pubmed.ncbi.nlm.nih.gov/42607209/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,42127200,Polyketide synthase-like functionality acquired by plant fatty acid elongase.,2026,10.1126/sciadv.aed2892,https://pubmed.ncbi.nlm.nih.gov/42127200/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,41208207,Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins.,2026,10.1002/advs.202509180,https://pubmed.ncbi.nlm.nih.gov/41208207/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,39181878,Channelrhodopsins with distinct chromophores and binding patterns.,2024,10.1038/s41467-024-51811-x,https://pubmed.ncbi.nlm.nih.gov/39181878/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,37071726,Elucidation of ALG10B as a Novel Long-QT Syndrome-Susceptibility Gene.,2023,10.1161/circgen.122.003726,https://pubmed.ncbi.nlm.nih.gov/37071726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,38658537,Kalium channelrhodopsins effectively inhibit neurons.,2024,10.1038/s41467-024-47203-w,https://pubmed.ncbi.nlm.nih.gov/38658537/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,34722422,Comprehensive Analysis of Genes Associated With Sudden Infant Death Syndrome.,2021,10.3389/fped.2021.742225,https://pubmed.ncbi.nlm.nih.gov/34722422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,35028856,Interaction of ONION2 ketoacyl CoA synthase with ketoacyl CoA reductase of rice.,2022,10.1007/s11033-021-07060-y,https://pubmed.ncbi.nlm.nih.gov/35028856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,35560210,Protein-protein interactions in fatty acid elongase complexes are important for very-long-chain fatty acid synthesis.,2022,10.1093/jxb/erab543,https://pubmed.ncbi.nlm.nih.gov/35560210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,38068920,Hub Genes in Stable QTLs Orchestrate the Accumulation of Cottonseed Oil in Upland Cotton via Catalyzing Key Steps of Lipid-Related Pathways.,2023,10.3390/ijms242316595,https://pubmed.ncbi.nlm.nih.gov/38068920/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,38999621,The Biosynthesis Pattern and Transcriptome Analysis of Sapindus saponaria Oil.,2024,10.3390/plants13131781,https://pubmed.ncbi.nlm.nih.gov/38999621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,33934225,"A detailed characterization of the hyperpolarization-activated ""funny"" current (If) in human-induced pluripotent stem cell (iPSC)-derived cardiomyocytes with pacemaker activity.",2021,10.1007/s00424-021-02571-w,https://pubmed.ncbi.nlm.nih.gov/33934225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,37769208,Tetracosanoic acids produced by 3-ketoacyl-CoA synthase 17 are required for synthesizing seed coat suberin in Arabidopsis.,2024,10.1093/jxb/erad381,https://pubmed.ncbi.nlm.nih.gov/37769208/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,35726059,Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition.,2022,10.1038/s41593-022-01094-6,https://pubmed.ncbi.nlm.nih.gov/35726059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,36466254,"Co-expression of stress-responsive regulatory genes, MuNAC4, MuWRKY3 and MuMYB96 associated with resistant-traits improves drought adaptation in transgenic groundnut (Arachis hypogaea l.) plants.",2022,10.3389/fpls.2022.1055851,https://pubmed.ncbi.nlm.nih.gov/36466254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,36119606,Alternative splicing of Arabidopsis G6PD5 recruits NADPH-producing OPPP reactions to the endoplasmic reticulum.,2022,10.3389/fpls.2022.909624,https://pubmed.ncbi.nlm.nih.gov/36119606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,32709014,"Time-Restricted G-Protein Signaling Pathways via GPR176, Gz, and RGS16 Set the Pace of the Master Circadian Clock in the Suprachiasmatic Nucleus.",2020,10.3390/ijms21145055,https://pubmed.ncbi.nlm.nih.gov/32709014/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,36714764,"Effect of 1-methylcyclopropene on peel greasiness, yellowing, and related gene expression in postharvest 'Yuluxiang' pear.",2022,10.3389/fpls.2022.1082041,https://pubmed.ncbi.nlm.nih.gov/36714764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,30604175,Arabidopsis Bax inhibitor-1 interacts with enzymes related to very-long-chain fatty acid synthesis.,2019,10.1007/s10265-018-01081-8,https://pubmed.ncbi.nlm.nih.gov/30604175/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,17993327,Impact of ancillary subunits on ventricular repolarization.,2007,10.1016/j.jelectrocard.2007.05.021,https://pubmed.ncbi.nlm.nih.gov/17993327/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALG10B,ENSG00000175548,Unsafe,14525949,The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.,2003,10.1096/fj.02-1057fje,https://pubmed.ncbi.nlm.nih.gov/14525949/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42616237,Three decades of anaplastic lymphoma kinase: from physiological roles to cancer and immune evasion.,2026,10.1007/s10555-026-10364-9,https://pubmed.ncbi.nlm.nih.gov/42616237/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42666775,Targeted immunotherapies for anaplastic lymphoma kinase-positive pediatric tumors: current advances and future perspectives.,2026,10.3389/fimmu.2026.1912199,https://pubmed.ncbi.nlm.nih.gov/42666775/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42739277,ALK Expression Without ALK Rearrangement in EWSR1::ATF1-Fused Inflammatory and Nested Testicular Sex Cord Tumor.,2026,10.3390/diagnostics16172847,https://pubmed.ncbi.nlm.nih.gov/42739277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42698427,Paratesticular myofibroblastic lesion in a prepubertal child: a case report of a rare spindle cell tumor with testis-sparing management.,2026,10.3389/fruro.2026.1866045,https://pubmed.ncbi.nlm.nih.gov/42698427/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42691832,Fusion isoform multiplicity and impact on treatment outcomes in ALK-rearranged non-small cell lung cancer with next-generation tyrosine kinase inhibitors.,2026,10.1016/j.lungcan.2026.109594,https://pubmed.ncbi.nlm.nih.gov/42691832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42243281,CircRNAs derived from the tyrosine phosphatase PTPN22 impact chemosensitivity in ALK-positive T-cell lymphomas.,2026,10.1038/s41598-026-54978-z,https://pubmed.ncbi.nlm.nih.gov/42243281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42738395,Performance of PRAME Immunohistochemistry in Distinguishing Classic Hodgkin Lymphoma from Anaplastic Large Cell Lymphoma and T-Cell Lymphoma.,2026,10.3390/cancers18172875,https://pubmed.ncbi.nlm.nih.gov/42738395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42755474,Advanced ALK-EML4 fusion-positive non-small cell lung cancer with intraspinal metastases: a case report.,2026,10.3389/fonc.2026.1916641,https://pubmed.ncbi.nlm.nih.gov/42755474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42530775,Leukemic presentation of ALK-positive anaplastic large cell lymphoma in an adult patient with hemophagocytic lymphohistiocytosis.,2026,10.1007/s12308-026-00724-3,https://pubmed.ncbi.nlm.nih.gov/42530775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42832421,STAG2 mutations fine-tune the ALK-driven oncogenic program in ALK-positive anaplastic large cell lymphoma.,2026,10.1182/blood.2025032902,https://pubmed.ncbi.nlm.nih.gov/42832421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42741428,Case Report: Single-cell transcriptomic profiling of a pediatric ALK-negative gastric inflammatory myofibroblastic tumor.,2026,10.3389/fimmu.2026.1855526,https://pubmed.ncbi.nlm.nih.gov/42741428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42597673,Physiologically based pharmacokinetic model of two ALK inhibitors to inform drug and dosing regimens for brain metastasis patients.,2026,10.3389/fphar.2026.1901617,https://pubmed.ncbi.nlm.nih.gov/42597673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42362808,"CircZBTB46, a promising therapeutic target in crizotinib resistant ALK-positive T lymphomas.",2026,10.1038/s41375-026-03018-w,https://pubmed.ncbi.nlm.nih.gov/42362808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42822275,The ALK inhibitor lorlatinib attenuates lipopolysaccharide-induced neuroinflammation by inhibiting microglial activation and preserving blood-brain barrier integrity.,2026,10.1016/j.intimp.2026.117478,https://pubmed.ncbi.nlm.nih.gov/42822275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42633176,The solitary skull mass: An atypical presentation of anaplastic large cell lymphoma.,2026,10.1016/j.radcr.2026.07.086,https://pubmed.ncbi.nlm.nih.gov/42633176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,41860822,Deciphering the cardiac neuron landscape in heart failure patients.,2026,10.1371/journal.pcbi.1014082,https://pubmed.ncbi.nlm.nih.gov/41860822/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42491373,Primary CNS Anaplastic Large Cell Lymphoma DUPS22 Rearranged with Gain of ALK: A Case Report and Review of the Literature.,2026,10.1002/jha2.70324,https://pubmed.ncbi.nlm.nih.gov/42491373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42793623,Treatment of an Advanced NSCLC Patient with a Rare OSBPL9-ALK Fusion: A Case Report.,2026,10.3390/healthcare14183085,https://pubmed.ncbi.nlm.nih.gov/42793623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42602356,ALK-negative anaplastic large cell lymphoma in pediatric and adolescent patients: a mini-review.,2026,10.3389/fonc.2026.1898680,https://pubmed.ncbi.nlm.nih.gov/42602356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42344690,Case Report: Alectinib and CNS-directed therapy for primary or relapsed ALK-positive anaplastic large cell lymphoma with central nervous system involvement.,2026,10.3389/fonc.2026.1679620,https://pubmed.ncbi.nlm.nih.gov/42344690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,41905770,Exploiting ALK inhibition in anaplastic large cell lymphoma: Biological rationale and therapeutic integration.,2026,10.1111/bjh.70458,https://pubmed.ncbi.nlm.nih.gov/41905770/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42642781,From molecular pathogenesis to novel Therapeutic approaches - a review of recent advances in the treatment of peripheral T cell Lymphomas.,2026,10.1186/s40364-026-00985-1,https://pubmed.ncbi.nlm.nih.gov/42642781/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42582769,Promising benefits of MET inhibition combined with EGFR/ALK tyrosine kinase inhibitor in heavily treated non-small cell lung cancer patients with &lt;i&gt;EGFR&lt;/i&gt;-mutant/&lt;i&gt;ALK&lt;/i&gt; rearrangement and MET overexpression: a retrospective cohort study.,2026,10.21037/tlcr-2026-0448,https://pubmed.ncbi.nlm.nih.gov/42582769/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42909156,The role of personalised medicine in treating high-risk neuroblastoma in paediatric patients.,2026,10.3389/or.2026.1850627,https://pubmed.ncbi.nlm.nih.gov/42909156/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42794929,"Multiple Options, One Objective: Clearer Decisions in Resectable Non-Small Cell Lung Cancer.",2026,10.3390/cancers18182963,https://pubmed.ncbi.nlm.nih.gov/42794929/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42641639,Crizotinib versus observation or placebo for surgically resected early-stage ALK-positive non-small-cell lung cancer (Eastern Cooperative Oncology Group-American College of Radiology Imaging Network E4512): a phase 3 trial.,2026,10.1016/s2213-2600(26)00192-x,https://pubmed.ncbi.nlm.nih.gov/42641639/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42151367,Lorlatinib monotherapy or combination therapy in anaplastic lymphoma kinase-driven high-risk neuroblastoma.,2026,10.1038/s41698-026-01487-x,https://pubmed.ncbi.nlm.nih.gov/42151367/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42769251,An exploratory case series of sequential stereotactic body radiotherapy and tislelizumab after platinum-doublet chemotherapy in stage IIIB/C-IV non-squamous NSCLC.,2026,10.3389/fimmu.2026.1854773,https://pubmed.ncbi.nlm.nih.gov/42769251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42524535,The Role of Precision Medicine in Neuroblastoma: Targeted Therapies and Personalized Approaches-A Narrative Review.,2026,10.1002/hsr2.72917,https://pubmed.ncbi.nlm.nih.gov/42524535/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42187575,Overcoming Acquired MET-Driven Resistance to First-Line Lorlatinib: Successful Combination of Lorlatinib and Envafolimab in an ALK-Positive NSCLC Patient with Ultra-High PD-L1 Expression.,2026,10.3390/curroncol33050258,https://pubmed.ncbi.nlm.nih.gov/42187575/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42211160,Advances in Pharmacological Treatment of Thoracic Malignancies.,2026,10.14789/ejmj.jmj25-0049-r,https://pubmed.ncbi.nlm.nih.gov/42211160/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42303632,Neoadjuvant retlirafusp alfa (anti-PD-L1/TGF-β bifunctional fusion protein) with or without chemotherapy in unresectable stage III non-small cell lung cancer: updated results from the phase 2 TRAILBLAZER trial.,2026,10.1038/s41392-026-02779-1,https://pubmed.ncbi.nlm.nih.gov/42303632/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42794900,The Adjuvant-Phase Dilemma After Neoadjuvant Chemoimmunotherapy in Resectable NSCLC: Evidence and Response-Guided Strategies.,2026,10.3390/cancers18182933,https://pubmed.ncbi.nlm.nih.gov/42794900/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42627772,Erratum.,2026,10.1159/000553551,https://pubmed.ncbi.nlm.nih.gov/42627772/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42661840,"Radioiodine-Refractory Differentiated Thyroid Cancer: Definition, Molecular Mechanisms, and Advances in Precision Therapy.",2026,10.1002/cai2.70078,https://pubmed.ncbi.nlm.nih.gov/42661840/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42569171,Rescuing a refractory Leiomyosarcoma: ALK-DCTN1 fusion as a gateway to long-term control with Ceritinib.,2026,10.1016/j.gore.2026.102175,https://pubmed.ncbi.nlm.nih.gov/42569171/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42539508,"Molecular testing, first-line treatment patterns, and survival in metastatic Colombian non-small cell lung cancer: the RECAPC multicenter registry.",2026,10.3389/fonc.2026.1863940,https://pubmed.ncbi.nlm.nih.gov/42539508/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,42449711,"Leptomeningeal Metastasis in Non-Small-Cell Lung Cancer with Actionable Genomic Alterations: Pathogenesis, Diagnosis, and Emerging Therapeutic Strategies.",2026,10.3390/cancers18132169,https://pubmed.ncbi.nlm.nih.gov/42449711/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALK,ENSG00000171094,Unsafe,9174053,"ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)",1997,10.1038/sj.onc.1201062,https://pubmed.ncbi.nlm.nih.gov/9174053/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,42643813,Interleukin-15-armored ALPPL2 CAR T cells demonstrate robust preclinical efficacy for solid tumors.,2026,10.1016/j.omton.2026.201319,https://pubmed.ncbi.nlm.nih.gov/42643813/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,40897818,Exosomal ALPPL2 and THBS2 as biomarkers for early detection and disease monitoring of pancreatic ductal adenocarcinoma.,2025,10.1038/s41416-025-03167-2,https://pubmed.ncbi.nlm.nih.gov/40897818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,42058906,AMPK-p38 axis converts human pluripotent stem cells to naive state.,2026,10.1016/j.isci.2026.115569,https://pubmed.ncbi.nlm.nih.gov/42058906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,36499122,Effect of Cross-Linking Cations on In Vitro Biocompatibility of Apple Pectin Gel Beads.,2022,10.3390/ijms232314789,https://pubmed.ncbi.nlm.nih.gov/36499122/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,32868383,ALPPL2 Is a Highly Specific and Targetable Tumor Cell Surface Antigen.,2020,10.1158/0008-5472.can-20-1418,https://pubmed.ncbi.nlm.nih.gov/32868383/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,37733038,5 -Alpha-dihydroxyprogesterone may contribute to perceptual processing and attention of the cases with relapsing remitting multiple sclerosis.,2024,10.1080/01616412.2023.2258040,https://pubmed.ncbi.nlm.nih.gov/37733038/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,37605769,Association of DNA methylation signatures with cognitive performance among smokers and ex-smokers.,2023,10.18332/tid/168568,https://pubmed.ncbi.nlm.nih.gov/37605769/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,33910981,SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models.,2021,10.1126/scitranslmed.abd8836,https://pubmed.ncbi.nlm.nih.gov/33910981/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,38560502,A genomic association study revealing subphenotypes of childhood steroid-sensitive nephrotic syndrome in a larger genomic sequencing cohort.,2024,10.1016/j.gendis.2023.101126,https://pubmed.ncbi.nlm.nih.gov/38560502/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,36160034,Transcriptome Sequencing Analysis of the Effect of β-Elemene on Colorectal Cancer from the lncRNA-miRNA-mRNA Perspective.,2022,10.1155/2022/5896296,https://pubmed.ncbi.nlm.nih.gov/36160034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,31687420,ALPPL2 Is a Potential Diagnostic Biomarker for Pancreatic Cancer-Derived Extracellular Vesicles.,2019,10.1016/j.omtm.2019.08.016,https://pubmed.ncbi.nlm.nih.gov/31687420/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,30496798,High expression of ALPPL2 is associated with poor prognosis in gastric cancer.,2019,10.1016/j.humpath.2018.11.019,https://pubmed.ncbi.nlm.nih.gov/30496798/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,37615099,Effects of CYP3A4 and CYP2C9 genotype on systemic anastrozole and fulvestrant concentrations in SWOG S0226.,2023,10.2217/pgs-2023-0097,https://pubmed.ncbi.nlm.nih.gov/37615099/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,35672317,Cell fate roadmap of human primed-to-naive transition reveals preimplantation cell lineage signatures.,2022,10.1038/s41467-022-30924-1,https://pubmed.ncbi.nlm.nih.gov/35672317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,30648747,Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2.,2019,10.1002/cpt.1359,https://pubmed.ncbi.nlm.nih.gov/30648747/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,34815689,Transcriptome Sequencing Explores the Mechanism of Baicalin on Bone Cancer Pain.,2021,10.2147/jir.s336028,https://pubmed.ncbi.nlm.nih.gov/34815689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,38238732,Proteomic associations with forced expiratory volume: a Mendelian randomisation study.,2024,10.1186/s12931-023-02587-z,https://pubmed.ncbi.nlm.nih.gov/38238732/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,31244887,The Effect of Genetic Variation on the Placental Transcriptome in Humans.,2019,10.3389/fgene.2019.00550,https://pubmed.ncbi.nlm.nih.gov/31244887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,27757273,Evaluation of anti-epileptic activity of leaf extracts of Punica granatum on experimental models of epilepsy in mice.,2016,10.5455/jice.20160904102857,https://pubmed.ncbi.nlm.nih.gov/27757273/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,25919296,ALPPL2 Aptamer-Mediated Targeted Delivery of 5-Fluoro-2'-Deoxyuridine to Pancreatic Cancer.,2015,10.1089/nat.2014.0516,https://pubmed.ncbi.nlm.nih.gov/25919296/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,41860794,Coexpression of IL15 Promotes Effector Differentiation and Sustained Proliferative Capacity in ALPPL2-Specific Human CAR T Cells.,2026,10.1158/2326-6066.cir-25-0609,https://pubmed.ncbi.nlm.nih.gov/41860794/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,40209501,Targeting ALPPL2 with a novel CD89 bispecific antibody reprograms macrophages to enhance anti-tumor immunity.,2025,10.1016/j.bbrc.2025.151761,https://pubmed.ncbi.nlm.nih.gov/40209501/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,24144296,"Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.",2013,10.1016/j.ajhg.2013.06.016,https://pubmed.ncbi.nlm.nih.gov/24144296/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,27935972,Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes.,2016,10.1371/journal.pone.0166486,https://pubmed.ncbi.nlm.nih.gov/27935972/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPG,ENSG00000163286,Unsafe,26580069,Analysis of Stage-Specific Gene Expression Profiles in the Uterine Endometrium during Pregnancy in Pigs.,2015,10.1371/journal.pone.0143436,https://pubmed.ncbi.nlm.nih.gov/26580069/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,41406940,Lung adenocarcinoma surfaceome remodeling with EGFR inhibitors uncovers placental alkaline phosphatase as a target for combination therapy.,2025,10.1016/j.xcrm.2025.102513,https://pubmed.ncbi.nlm.nih.gov/41406940/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,41459136,ALPP Induces Epithelial-Mesenchymal Transition by Activating the Wnt/β-Catenin Signaling Pathway in Colorectal Cancer Cells.,2025,10.2147/cmar.s545808,https://pubmed.ncbi.nlm.nih.gov/41459136/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,41209549,Aberrant ALPP Expression Serves as a Prognostic Biomarker and Facilitates Cholangiocarcinoma Progression through Immune Evasion and PI3K-Akt Signaling Activation.,2025,10.7150/ijms.116260,https://pubmed.ncbi.nlm.nih.gov/41209549/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,42294307,Case Report: Primary choriocarcinoma of the pineal region.,2026,10.3389/fonc.2026.1822123,https://pubmed.ncbi.nlm.nih.gov/42294307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,41058463,ALPHA-TOCOPHEROL AND G-CSF CHANGE EXPRESSION OF GENES ASSOCIATED WITH DIFFERENTIATION OF K562 CHRONIC MYELOID LEUKEMIA CELLS DOWNREGULATING EMT-ASSOCIATED STEMNESS BIOMARKERS.,2025,10.15407/exp-oncology.2025.02.181,https://pubmed.ncbi.nlm.nih.gov/41058463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,42292176,Giant seminoma of the testis (2.51 kg) in a setting of severe occupational and lifestyle exposures: a case report and pathophysiological insights.,2026,10.3389/fmed.2026.1850712,https://pubmed.ncbi.nlm.nih.gov/42292176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,42126615,Synergistic repair of pelvic floor supportive tissues in rats with stress urinary incontinence by electroacupuncture combined with repetitive transspinal magnetic stimulation and mechanisms of action.,2026,10.1007/s00345-026-06422-0,https://pubmed.ncbi.nlm.nih.gov/42126615/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,42305115,Sensitivity and specificity of cerebrospinal fluid placental alkaline phosphatase in germinoma: An 8 pg/mL threshold.,2026,10.1093/noajnl/vdag145,https://pubmed.ncbi.nlm.nih.gov/42305115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,42727296,Biodegradable poly(lipoic acid)-based adhesive orchestrates tunable antibacterial activity and controlled H&lt;sub&gt;2&lt;/sub&gt; release for peri-implant soft tissue integration.,2026,10.1016/j.biomaterials.2026.124618,https://pubmed.ncbi.nlm.nih.gov/42727296/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,41185737,A Case of Spermatocytic Tumor of Testis.,2025,10.1002/iju5.70089,https://pubmed.ncbi.nlm.nih.gov/41185737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,41909428,Abdominal Leak Point Pressures During Cough and Valsalva: What Do the Different Maneuvers Hide?,2026,10.7759/cureus.104168,https://pubmed.ncbi.nlm.nih.gov/41909428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,39680294,PLAP expression is linked to invasive tumor growth in urothelial carcinoma of the bladder.,2025,10.1007/s11255-024-04319-8,https://pubmed.ncbi.nlm.nih.gov/39680294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,42568137,Metachronous Pineal Germinoma 11 Years After Total Resection of a Mature Teratoma.,2026,10.1111/neup.70073,https://pubmed.ncbi.nlm.nih.gov/42568137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,42465829,Thalamo-peduncular germinoma in a young adult: a case report.,2026,10.11604/pamj.2026.53.109.50181,https://pubmed.ncbi.nlm.nih.gov/42465829/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,42667637,"Placental Extracellular Vesicles in Preeclampsia: Molecular Cargo, Pathophysiological Roles, and Emerging Diagnostic and Therapeutic Frontiers.",2026,10.1111/aji.70315,https://pubmed.ncbi.nlm.nih.gov/42667637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,41845589,Metformin enhances external urethral sphincter integrity and restores continence via AMPK activation in a rat model of stress urinary incontinence.,2026,10.1002/ame2.70171,https://pubmed.ncbi.nlm.nih.gov/41845589/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,42053631,Collagen remodeling drives continence recovery: radiofrequency therapy ameliorates SUI via TGF-β1/Smad2 pathway activation - evidence from a rat model.,2026,10.1007/s10103-026-04879-4,https://pubmed.ncbi.nlm.nih.gov/42053631/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,39793469,Placental alkaline phosphatase (PLAP): Is it exclusively placental?,2025,10.1016/j.placenta.2025.01.001,https://pubmed.ncbi.nlm.nih.gov/39793469/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,41356390,Germ cell immunoprofile and KIT exon 17 mutation guide rectification of seminoma misclassified as epithelioid gastrointestinal stromal tumor: A case report.,2026,10.3892/br.2025.2088,https://pubmed.ncbi.nlm.nih.gov/41356390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,39981229,Evaluation of the immunological functions of placental alkaline phosphatase &lt;i&gt;in vivo&lt;/i&gt; using ALPP transgenic mice.,2025,10.3389/fimmu.2025.1499388,https://pubmed.ncbi.nlm.nih.gov/39981229/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,42643327,Urodynamic characteristics and clinical significance of detrusor overactivity in early (≤6 months) male urinary incontinence following TURP and RARP: a descriptive analysis of two cohorts.,2026,10.3389/fonc.2026.1902283,https://pubmed.ncbi.nlm.nih.gov/42643327/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,42729169,Early continence and postoperative urodynamic findings after single-port transvesical robot-assisted radical prostatectomy: a preliminary prospective physiologic case series.,2026,10.21037/tau-2026-0368,https://pubmed.ncbi.nlm.nih.gov/42729169/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,42580172,Repurposing nucleos(t)ide analogs as purine nucleoside phosphorylase inhibitors through Gaussian accelerated molecular dynamics simulations.,2026,10.1016/j.bbrc.2026.154333,https://pubmed.ncbi.nlm.nih.gov/42580172/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,41339246,A Rare Case of Primary Bladder Lymphoepithelial Carcinoma.,2025,10.56434/j.arch.esp.urol.20257809.175,https://pubmed.ncbi.nlm.nih.gov/41339246/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,36139135,Generation and Functional Characterization of PLAP CAR-T Cells against Cervical Cancer Cells.,2022,10.3390/biom12091296,https://pubmed.ncbi.nlm.nih.gov/36139135/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,41444232,Proteomic signatures of smoking and their associations with risk of incident diseases and mortality in diverse populations.,2025,10.1038/s41467-025-67656-x,https://pubmed.ncbi.nlm.nih.gov/41444232/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,41266492,Placenta-derived extracellular vesicles in maternal plasma of Hb Bart's fetuses.,2025,10.1038/s41598-025-24900-0,https://pubmed.ncbi.nlm.nih.gov/41266492/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,40914405,Exploration of endoplasmic reticulum stress-related gene markers in amyotrophic lateral sclerosis: a comprehensive analysis of bioinformatics and machine learning.,2025,10.1016/j.ab.2025.115969,https://pubmed.ncbi.nlm.nih.gov/40914405/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,34939766,Evaluation of Placental Alkaline Phosphatase Expression as A Potential Target of Solid Tumors Immunotherapy by Using Gene and Protein Expression Repositories.,2021,10.22074/cellj.2021.7299,https://pubmed.ncbi.nlm.nih.gov/34939766/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,41695364,Hepatic carcinosarcoma: a rare and aggressive case with unusual molecular signature!,2026,10.3389/fonc.2026.1759219,https://pubmed.ncbi.nlm.nih.gov/41695364/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,32472757,PLAP -CAR T cells mediate high specific cytotoxicity against colon cancer cells.,2020,10.2741/4877,https://pubmed.ncbi.nlm.nih.gov/32472757/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,40009685,Rapid and high-sensitivity screening of pregnancy complications by profiling circulating placental extracellular vesicles.,2025,10.1126/sciadv.adr4074,https://pubmed.ncbi.nlm.nih.gov/40009685/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ALPP,ENSG00000163283,Unsafe,20693656,Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.,2010,10.1107/s1744309110019767,https://pubmed.ncbi.nlm.nih.gov/20693656/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,41695731,"Osteopathia striata with cranial sclerosis, associated with juvenile idiopathic arthritis: A case report and review of literature.",2026,10.5312/wjo.v17.i2.113473,https://pubmed.ncbi.nlm.nih.gov/41695731/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,41091816,"Mathematical Modeling Quantifies ""Just-Right"" APC Inactivation for Colorectal Cancer Initiation.",2025,10.1158/0008-5472.can-25-0445,https://pubmed.ncbi.nlm.nih.gov/41091816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,42804781,Primary Vulvar HPV-independent Adenosquamous Carcinoma: A Case Series of a Rare Neoplasm With an Apparent Predilection for the Upper Vulva.,2026,10.1097/pgp.0000000000001206,https://pubmed.ncbi.nlm.nih.gov/42804781/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,38255806,amer1 Regulates Zebrafish Craniofacial Development by Interacting with the Wnt/β-Catenin Pathway.,2024,10.3390/ijms25020734,https://pubmed.ncbi.nlm.nih.gov/38255806/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,41154418,Molecular Characterization of Seminoma Utilizing the AACR Project GENIE: A Retrospective Observational Study.,2025,10.3390/cancers17203363,https://pubmed.ncbi.nlm.nih.gov/41154418/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,41330877,Diagnostic Value of Exome Sequencing in Isolated Polyhydramnios.,2026,10.1002/pd.70030,https://pubmed.ncbi.nlm.nih.gov/41330877/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,42511540,Artificial Intelligence-Enabled Analysis of WNT Pathway Dysregulation in Bevacizumab-Treated Early-Onset Colorectal Cancer.,2026,10.3390/ijms27146195,https://pubmed.ncbi.nlm.nih.gov/42511540/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,38801192,Osteopathia striata with cranial sclerosis as a cancer predisposition syndrome: The first report of neuroblastoma and review of all cancers in OSCS.,2024,10.1002/ajmg.a.63709,https://pubmed.ncbi.nlm.nih.gov/38801192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,40107724,Optical genome mapping identifies rare structural variants in neural tube defects.,2025,10.1101/gr.279318.124,https://pubmed.ncbi.nlm.nih.gov/40107724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,42150146,Systematic Review: Prognostic Molecular Biomarkers in Wilms Tumors.,2026,10.1200/po-25-01017,https://pubmed.ncbi.nlm.nih.gov/42150146/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,38504345,"Epigenetic MLH1 silencing concurs with mismatch repair deficiency in sporadic, naturally occurring colorectal cancer in rhesus macaques.",2024,10.1186/s12967-024-04869-6,https://pubmed.ncbi.nlm.nih.gov/38504345/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,41326213,Current status and clinical usefulness of genomic panel testing using PleSSision-160 in resectable esophageal squamous cell carcinoma.,2025,10.1016/j.ejso.2025.110481,https://pubmed.ncbi.nlm.nih.gov/41326213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,33856753,Osteopathia Striata with Cranial Sclerosis,1993,,https://pubmed.ncbi.nlm.nih.gov/33856753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,36581928,Intestinal malrotation in a female newborn affected by Osteopathia Striata with Cranial Sclerosis due to a de novo heterozygous nonsense mutation of the AMER1 gene.,2022,10.1186/s13052-022-01403-6,https://pubmed.ncbi.nlm.nih.gov/36581928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,38970069,Molecular alterations and prognosis of breast cancer with cutaneous metastasis.,2024,10.1186/s13000-024-01509-x,https://pubmed.ncbi.nlm.nih.gov/38970069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,32365332,KIF23 activated Wnt/β-catenin signaling pathway through direct interaction with Amer1 in gastric cancer.,2020,10.18632/aging.103146,https://pubmed.ncbi.nlm.nih.gov/32365332/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,40050208,Intra-clustering analysis reveals tissue-specific mutational patterns.,2025,10.1016/j.cmpb.2025.108681,https://pubmed.ncbi.nlm.nih.gov/40050208/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,38731939,Gene Expression and DNA Methylation Profiling Suggest Potential Biomarkers for Azacitidine Resistance in Myelodysplastic Syndrome.,2024,10.3390/ijms25094723,https://pubmed.ncbi.nlm.nih.gov/38731939/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,35991531,Mosaic Deletions of Known Genes Explain Skeletal Dysplasias With High and Low Bone Mass.,2022,10.1002/jbm4.10660,https://pubmed.ncbi.nlm.nih.gov/35991531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,35685408,Treatment of Metastatic Primary Extramammary Paget Disease With Combination Anlotinib and Tislelizumab: A Case Report and Review of the Literature.,2022,10.3389/fmed.2022.891958,https://pubmed.ncbi.nlm.nih.gov/35685408/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,42546913,Tumoral AMER1 driven dopamine synthesis triggers cancer cell pyroptosis and licenses CD8&lt;sup&gt;+&lt;/sup&gt; T cell immunity in colorectal cancer.,2026,10.1016/j.canlet.2026.218772,https://pubmed.ncbi.nlm.nih.gov/42546913/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,39095235,Mutations Associated With High-Grade irAEs in NSCLC Patients Receiving Immunotherapies.,2024,10.1016/j.cllc.2024.07.003,https://pubmed.ncbi.nlm.nih.gov/39095235/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,37146911,Molecular Profiling Provides Clinical Insights Into Targeted and Immunotherapies as Well as Colorectal Cancer Prognosis.,2023,10.1053/j.gastro.2023.04.029,https://pubmed.ncbi.nlm.nih.gov/37146911/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,37697729,Clear Cell Adenocarcinoma of Urethra: Clinical and Pathologic Implications and Characterization of Molecular Aberrations.,2024,10.4143/crt.2023.577,https://pubmed.ncbi.nlm.nih.gov/37697729/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,34791810,Circulating tumor DNA predicts the outcome of chemotherapy in patients with lung cancer.,2022,10.1111/1759-7714.14230,https://pubmed.ncbi.nlm.nih.gov/34791810/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,33489799,"Predictive values of genomic variation, tumor mutational burden, and PD-L1 expression in advanced lung squamous cell carcinoma treated with immunotherapy.",2020,10.21037/tlcr-20-1130,https://pubmed.ncbi.nlm.nih.gov/33489799/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,37114476,"Specific Mutations in APC, with Prognostic Implications in Metastatic Colorectal Cancer.",2023,10.4143/crt.2023.415,https://pubmed.ncbi.nlm.nih.gov/37114476/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,24265322,β-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein.,2014,10.1074/jbc.m113.498444,https://pubmed.ncbi.nlm.nih.gov/24265322/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,31765373,Molecular characterization of lung adenocarcinoma from Korean patients using next generation sequencing.,2019,10.1371/journal.pone.0224379,https://pubmed.ncbi.nlm.nih.gov/31765373/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,24251807,"Adenomatous polyposis coli (APC) membrane recruitment 3, a member of the APC membrane recruitment family of APC-binding proteins, is a positive regulator of Wnt-β-catenin signalling.",2014,10.1111/febs.12624,https://pubmed.ncbi.nlm.nih.gov/24251807/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,31080553,Driver genes exome sequencing reveals distinct variants in African Americans with colorectal neoplasia.,2019,10.18632/oncotarget.26721,https://pubmed.ncbi.nlm.nih.gov/31080553/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMER1,ENSG00000184675,Unsafe,19416806,The tumor suppressor WTX shuttles to the nucleus and modulates WT1 activity.,2009,10.1073/pnas.0811349106,https://pubmed.ncbi.nlm.nih.gov/19416806/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMIGO3,ENSG00000176020,Unsafe,34650403,The Role and Mechanism of AMIGO3 in the Formation of Aberrant Neural Circuits After Status Convulsion in Immature Mice.,2021,10.3389/fnmol.2021.748115,https://pubmed.ncbi.nlm.nih.gov/34650403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMIGO3,ENSG00000176020,Unsafe,35094710,Establishment of an antibody specific for AMIGO2 improves immunohistochemical evaluation of liver metastases and clinical outcomes in patients with colorectal cancer.,2022,10.1186/s13000-021-01176-2,https://pubmed.ncbi.nlm.nih.gov/35094710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMIGO3,ENSG00000176020,Unsafe,28966634,"LINGO-1 and AMIGO3, potential therapeutic targets for neurological and dysmyelinating disorders?",2017,10.4103/1673-5374.213538,https://pubmed.ncbi.nlm.nih.gov/28966634/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMIGO3,ENSG00000176020,Unsafe,30013050,Non-viral-mediated suppression of AMIGO3 promotes disinhibited NT3-mediated regeneration of spinal cord dorsal column axons.,2018,10.1038/s41598-018-29124-z,https://pubmed.ncbi.nlm.nih.gov/30013050/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMIGO3,ENSG00000176020,Unsafe,35395711,Bioinformatics analysis reveals immune prognostic markers for overall survival of colorectal cancer patients: a novel machine learning survival predictive system.,2022,10.1186/s12859-022-04657-3,https://pubmed.ncbi.nlm.nih.gov/35395711/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMIGO3,ENSG00000176020,Unsafe,23613963,AMIGO3 is an NgR1/p75 co-receptor signalling axon growth inhibition in the acute phase of adult central nervous system injury.,2013,10.1371/journal.pone.0061878,https://pubmed.ncbi.nlm.nih.gov/23613963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMIGO3,ENSG00000176020,Unsafe,34832436,The Effect of AlI3 Nanoadditive on the Thermal Behavior of PMMA Subjected to Thermoanalytical Py-GC-MS Technique.,2021,10.3390/ma14227036,https://pubmed.ncbi.nlm.nih.gov/34832436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMIGO3,ENSG00000176020,Unsafe,26191384,Anti-aging Effect and Gene Expression Profiling of Aged Rats Treated with G. bimaculatus Extract.,2015,10.5487/tr.2015.31.2.173,https://pubmed.ncbi.nlm.nih.gov/26191384/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMIGO3,ENSG00000176020,Unsafe,31744923,A Fungal Arrestin Protein Contributes to Cell Cycle Progression and Pathogenesis.,2019,10.1128/mbio.02682-19,https://pubmed.ncbi.nlm.nih.gov/31744923/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMIGO3,ENSG00000176020,Unsafe,12629050,"AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats.",2003,10.1083/jcb.200209074,https://pubmed.ncbi.nlm.nih.gov/12629050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AMIGO3,ENSG00000176020,Unsafe,2391687,Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis.,1990,10.1021/jm00171a019,https://pubmed.ncbi.nlm.nih.gov/2391687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42793172,Tissue-Specific Angiogenic Responses to Exercise: Mechanisms and Research Advances.,2026,10.3390/biom16091340,https://pubmed.ncbi.nlm.nih.gov/42793172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42540656,Probiotics in Combination with C16 Peptide and Angiopoietin-1 Synergistically Ameliorate Multiple Sclerosis in Mice.,2026,10.2147/dddt.s614294,https://pubmed.ncbi.nlm.nih.gov/42540656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42835014,Differential expression and clinical significance of angiotensin (1-7)/Ang II and Elabela/Ang II ratios in patients with acute heart failure and type I cardiorenal syndrome.,2026,10.3389/fmed.2026.1912581,https://pubmed.ncbi.nlm.nih.gov/42835014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42738844,Targeting the ACE/Ang II Axis with Captopril Attenuates Neuroinflammation and Cerebral Injury Following Fat Embolism.,2026,10.3390/cells15171550,https://pubmed.ncbi.nlm.nih.gov/42738844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42230965,Sex-specific regulation of angiogenin in Alzheimer's disease.,2026,10.1038/s41380-026-03656-7,https://pubmed.ncbi.nlm.nih.gov/42230965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42368404,A Brain-Targeted Organophosphorus Hydrolase Fusion Protein Mediated by Angiopep-2 Neutralizes Central Organophosphates and Alleviates Neurotoxicity.,2026,10.2147/ijn.s604162,https://pubmed.ncbi.nlm.nih.gov/42368404/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42511485,Systemic Molecular Network Alterations Associated with FoxA2 in Gastric Cancer.,2026,10.3390/ijms27146126,https://pubmed.ncbi.nlm.nih.gov/42511485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42563396,Targeting of Pentraxin 3 Alleviated Cardiac Hypertrophy in Mice Induced by Angiotensin II.,2026,10.1111/1440-1681.70139,https://pubmed.ncbi.nlm.nih.gov/42563396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42734292,Age-related alterations in the brain ACE2/Ang-(1-7)/Mas receptor axis in normotensive and spontaneously hypertensive rats.,2026,10.1042/cs20261834,https://pubmed.ncbi.nlm.nih.gov/42734292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42787653,Role of hypoxia-inducible factor - 1 alpha on the progression of cervical intraepithelial neoplasia and cervical cancer: a narrative review.,2026,10.3389/fonc.2026.1922814,https://pubmed.ncbi.nlm.nih.gov/42787653/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42650256,Neuroprotective Potential of Peptide KSVSPKFLTG from &lt;i&gt;Magallana gigas&lt;/i&gt; via Activating the ACE2/Ang-(1-7)/Mas Axis in SHSY-5Y Cells.,2026,10.3390/antiox15080992,https://pubmed.ncbi.nlm.nih.gov/42650256/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42592017,Endotheliopathy in CAR T-Cell Therapy: Mechanistic Insights into the VWF/ADAMTS13 Axis and the Angiopoietin-Tie2 Pathway.,2026,10.1055/a-2923-1208,https://pubmed.ncbi.nlm.nih.gov/42592017/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42397758,SIRT6 Attenuates Angiotensin II-Induced Podocyte Cholesterol Accumulation and Injury via Negative Modulation of SREBP2.,2026,10.1159/000552307,https://pubmed.ncbi.nlm.nih.gov/42397758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42707698,Cardiomyocyte-Specific RNF128 Attenuates Pathological Cardiac Hypertrophy Progression by Stabilizing SERCA2a through Lys63-Linked Polyubiquitination.,2026,10.7150/thno.133221,https://pubmed.ncbi.nlm.nih.gov/42707698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42323339,Hydrogen sulfide mitigates spatial learning deficits in angiotensin II-Induced hypertension via inhibition of endothelial NOX2 and neuroinflammation.,2026,10.1038/s41398-026-04178-0,https://pubmed.ncbi.nlm.nih.gov/42323339/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42653310,"Important Role of Renin-Angiotensin System and Vasopressin System in Cardiovascular, Metabolic and Psychogenic Disorders in Pregnancy and Early Postnatal Life: A Narrative Review.",2026,10.3390/ijms27167309,https://pubmed.ncbi.nlm.nih.gov/42653310/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42268789,Higher Expression of miR-155 and miR-103 in Patients with Gitelman Syndrome: Potential Implications for Angiotensin II-Induced Cardiovascular Remodeling in Hypertension.,2026,10.1159/000552985,https://pubmed.ncbi.nlm.nih.gov/42268789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42680803,Altered ANG/TIE gene expression in advanced ovarian cancer is not accompanied by disproportionate body water accumulation relative to perioperative fluid balance.,2026,10.1038/s41598-026-68951-3,https://pubmed.ncbi.nlm.nih.gov/42680803/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,41992448,Angiopep-2-decorated bacterial outer membrane vesicles penetrate the blood-brain barrier for glioblastoma chemo-immunotherapy.,2026,10.1080/10717544.2026.2660007,https://pubmed.ncbi.nlm.nih.gov/41992448/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,41831566,AMPK inhibition and elevated angiogenin are associated with tRNA fragmentation in the male germline exposed to a high-fat diet.,2026,10.1016/j.molmet.2026.102350,https://pubmed.ncbi.nlm.nih.gov/41831566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,41899579,An Image-Guided Combination Strategy: Immediate Hepatic Arterial Infusion of Nivolumab Following Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma.,2026,10.3390/cancers18060978,https://pubmed.ncbi.nlm.nih.gov/41899579/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,41766910,Tumor immune-vascular crosstalk: synergy and translation of immune checkpoint inhibitors and anti-angiogenic agents in melanoma.,2026,10.3389/fimmu.2026.1760044,https://pubmed.ncbi.nlm.nih.gov/41766910/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42609206,"Angiotensin-(1-7) in asthma and pulmonary fibrosis: mechanisms of action, clinical safety, and nano-delivery strategies.",2026,10.3389/fphar.2026.1789833,https://pubmed.ncbi.nlm.nih.gov/42609206/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,39851099,Angelicin Inhibits NSCLC Tumor Growth via the Inhibition of Cancer-Associated Fibroblasts.,2026,10.2174/0113862073366593250109093910,https://pubmed.ncbi.nlm.nih.gov/39851099/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42572402,CD31&lt;sup&gt;+&lt;/sup&gt; T-cells express greater VEGF-A than CD31&lt;sup&gt;-&lt;/sup&gt; counterparts with expression exacerbated with advancing age in male adults.,2026,10.14814/phy2.71057,https://pubmed.ncbi.nlm.nih.gov/42572402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42864373,Angiotensin peptide and aldosterone concentrations in response to four classes of blood-pressure-lowering drugs in hypertensive patients: A randomized trial.,2026,10.1038/s41371-026-01239-1,https://pubmed.ncbi.nlm.nih.gov/42864373/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,41908738,Clinical Outcomes of Osimertinib Combined with Platinum-Based Chemotherapy in EGFR-Mutant Non-Small Cell Lung Cancer: A Retrospective Study.,2026,10.2147/pgpm.s566952,https://pubmed.ncbi.nlm.nih.gov/41908738/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42035162,Overcoming blood-brain barrier and chemoresistance in glioblastoma by Angiopep-2-modified NK cell-derived extracellular vesicles for targeted delivery of temozolomide.,2026,10.1186/s12951-026-04315-3,https://pubmed.ncbi.nlm.nih.gov/42035162/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,41601934,"Antibody-based therapeutics and therapeutic development for diabetic retinopathy: targeting VEGF, Ang/Tie, and inflammatory pathways.",2025,10.3389/fendo.2025.1710376,https://pubmed.ncbi.nlm.nih.gov/41601934/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42375149,"Effects of Liposomal Bupivacaine for Superficial Parasternial Intercostal Plane Block on Postoperative Stress and Analgesia in Patients Undergoing Median Sternotomy: A Prospective, Randomized, Double-Blind Trial.",2026,10.2147/dddt.s597889,https://pubmed.ncbi.nlm.nih.gov/42375149/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,41301459,Advances in Understanding Renin-Angiotensin System-Mediated Anti-Tumor Activity of Natural Polyphenols.,2025,10.3390/biom15111541,https://pubmed.ncbi.nlm.nih.gov/41301459/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42043950,An mRNA Tumor Nanovaccine Expressing Tumor Antigen Fused With Angiotensin II Facilitates Type 1 Conventional Dendritic Cell-Mediated Anti-Tumor Immunity.,2026,10.1002/smll.202513524,https://pubmed.ncbi.nlm.nih.gov/42043950/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42765426,"Although myeloid-cell RGS2 knockout does not affect Ang II-induced hypertension/organ damage in mice, high RGS2 in Gitelman/Bartter syndromes-human models of endogenous Ang II signaling antagonism-is associated with hypotensive/antiremodeling effects.",2026,10.14814/phy2.71110,https://pubmed.ncbi.nlm.nih.gov/42765426/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,40474872,"Bevacizumab in ovarian cancer therapy: current advances, clinical challenges, and emerging strategies.",2025,10.3389/fbioe.2025.1589841,https://pubmed.ncbi.nlm.nih.gov/40474872/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42265329,The blood pressure-lowering effect of an anti-soluble epoxide hydrolase vaccine in angiotensin II-induced hypertension in mice.,2026,10.1038/s41440-026-02697-3,https://pubmed.ncbi.nlm.nih.gov/42265329/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,42512278,Reprogramming Tumorigenesis and the Tumor Microenvironment with Flavokawains.,2026,10.3390/cancers18142211,https://pubmed.ncbi.nlm.nih.gov/42512278/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,17886298,Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis.,2007,10.1002/ana.21221,https://pubmed.ncbi.nlm.nih.gov/17886298/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANG,ENSG00000214274,Unsafe,2440105,Tissue distribution and developmental expression of the messenger RNA encoding angiogenin.,1987,10.1126/science.2440105,https://pubmed.ncbi.nlm.nih.gov/2440105/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKAR,ENSG00000151687,Unsafe,39693144,A large-scale proteomics resource of circulating extracellular vesicles for biomarker discovery in pancreatic cancer.,2024,10.7554/elife.87369,https://pubmed.ncbi.nlm.nih.gov/39693144/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKAR,ENSG00000151687,Unsafe,37828440,Sequence-based GWAS meta-analyses for beef production traits.,2023,10.1186/s12711-023-00848-5,https://pubmed.ncbi.nlm.nih.gov/37828440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKAR,ENSG00000151687,Unsafe,20648054,"Hemizygous deletion of COL3A1, COL5A2, and MSTN causes a complex phenotype with aortic dissection: a lesson for and from true haploinsufficiency.",2010,10.1038/ejhg.2010.105,https://pubmed.ncbi.nlm.nih.gov/20648054/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKAR,ENSG00000151687,Unsafe,15110750,Characterization of a novel human gene containing ANK repeats and ARM domains.,2004,10.1016/j.bbrc.2004.03.186,https://pubmed.ncbi.nlm.nih.gov/15110750/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD33,ENSG00000167612,Unsafe,41512684,Placental gene expression signatures based on maternal parity.,2026,10.1016/j.placenta.2026.01.002,https://pubmed.ncbi.nlm.nih.gov/41512684/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD33,ENSG00000167612,Unsafe,37606455,Excessive Gestational Weight Gain Alters DNA Methylation and Influences Foetal and Neonatal Body Composition.,2023,10.3390/epigenomes7030018,https://pubmed.ncbi.nlm.nih.gov/37606455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD33,ENSG00000167612,Unsafe,31314707,ANKRD33 is overexpressed in gastric adenocarcinoma and predictive for poor prognosis.,2019,10.1080/09168451.2019.1642100,https://pubmed.ncbi.nlm.nih.gov/31314707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD33,ENSG00000167612,Unsafe,37205010,The Underlying Mechanism Involved in Gefitinib Resistance and Corresponding Experiment Validation in Lung Cancer.,2023,10.1155/2023/9658912,https://pubmed.ncbi.nlm.nih.gov/37205010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD33,ENSG00000167612,Unsafe,38372747,Genome-wide DNA methylation analysis related to ALS patient progression and survival.,2024,10.1007/s00415-024-12222-6,https://pubmed.ncbi.nlm.nih.gov/38372747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD33,ENSG00000167612,Unsafe,31934309,Novel eye genes systematically discovered through an integrated analysis of mouse transcriptomes and phenome.,2020,10.1016/j.csbj.2019.12.009,https://pubmed.ncbi.nlm.nih.gov/31934309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD33,ENSG00000167612,Unsafe,20026326,"Panky, a novel photoreceptor-specific ankyrin repeat protein, is a transcriptional cofactor that suppresses CRX-regulated photoreceptor genes.",2010,10.1016/j.febslet.2009.12.030,https://pubmed.ncbi.nlm.nih.gov/20026326/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD33,ENSG00000167612,Unsafe,33859359,Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.,2021,10.1038/s41380-021-01087-0,https://pubmed.ncbi.nlm.nih.gov/33859359/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD33,ENSG00000167612,Unsafe,30071075,A genome-wide association study of energy intake and expenditure.,2018,10.1371/journal.pone.0201555,https://pubmed.ncbi.nlm.nih.gov/30071075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD33,ENSG00000167612,Unsafe,22784109,NeuroD1 is required for survival of photoreceptors but not pinealocytes: results from targeted gene deletion studies.,2012,10.1111/j.1471-4159.2012.07870.x,https://pubmed.ncbi.nlm.nih.gov/22784109/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD36B,ENSG00000196912,Unsafe,38178908,Plasma cell-free RNA profiling of Vietnamese Alzheimer's patients reveals a linkage with chronic inflammation and apoptosis: a pilot study.,2023,10.3389/fnmol.2023.1308610,https://pubmed.ncbi.nlm.nih.gov/38178908/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD36B,ENSG00000196912,Unsafe,35038288,Whole-exome sequencing reveals rare genetic variations in ovarian granulosa cell tumor.,2022,10.17305/bjbms.2021.6789,https://pubmed.ncbi.nlm.nih.gov/35038288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD36B,ENSG00000196912,Unsafe,36872244,[Bioinformatics analysis and validation of key genes in transformation of idiopathic membranous nephropathy to end-stage renal disease and traditional Chinese medicines for prevention and treatment].,2023,10.19540/j.cnki.cjcmm.20220901.501,https://pubmed.ncbi.nlm.nih.gov/36872244/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD36B,ENSG00000196912,Unsafe,34827175,Integrated Genomic Analysis Identifies ANKRD36 Gene as a Novel and Common Biomarker of Disease Progression in Chronic Myeloid Leukemia.,2021,10.3390/biology10111182,https://pubmed.ncbi.nlm.nih.gov/34827175/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD36B,ENSG00000196912,Unsafe,22276153,Differential gene expression between African American and European American colorectal cancer patients.,2012,10.1371/journal.pone.0030168,https://pubmed.ncbi.nlm.nih.gov/22276153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD45,ENSG00000183831,Unsafe,42899482,Tumour Antigen-Specific Antibody Signatures as Diagnostic Biomarkers for Melanoma.,2026,10.1002/ijc.70726,https://pubmed.ncbi.nlm.nih.gov/42899482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD45,ENSG00000183831,Unsafe,41448503,Context-specific expression quantitative trait loci dynamics uncover genetic pleiotropy in schizophrenia.,2026,10.1016/j.nbd.2025.107236,https://pubmed.ncbi.nlm.nih.gov/41448503/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD45,ENSG00000183831,Unsafe,39409106,Development and Validation of a Comprehensive Prognostic and Depression Risk Index for Gastric Adenocarcinoma.,2024,10.3390/ijms251910776,https://pubmed.ncbi.nlm.nih.gov/39409106/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD45,ENSG00000183831,Unsafe,31208154,Ankrd45 Is a Novel Ankyrin Repeat Protein Required for Cell Proliferation.,2019,10.3390/genes10060462,https://pubmed.ncbi.nlm.nih.gov/31208154/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD45,ENSG00000183831,Unsafe,35626094,Three-Dimensional Organotypic Cultures Reshape the microRNAs Transcriptional Program in Breast Cancer Cells.,2022,10.3390/cancers14102490,https://pubmed.ncbi.nlm.nih.gov/35626094/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD45,ENSG00000183831,Unsafe,28418032,A New Approach to Evaluating Aberrant DNA Methylation Profiles in Hepatocellular Carcinoma as Potential Biomarkers.,2017,10.1038/srep46533,https://pubmed.ncbi.nlm.nih.gov/28418032/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,41090353,ANKRD55 is a key regulator of T cell inflammation in multiple sclerosis.,2025,10.1172/jci195214,https://pubmed.ncbi.nlm.nih.gov/41090353/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,42052224,Investigating the Pleiotropic Role of KIF21B in Schizophrenia and Multiple Sclerosis: A Bioinformatics Analysis.,2026,10.36131/cnfioritieditore20260202,https://pubmed.ncbi.nlm.nih.gov/42052224/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,40932625,Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation.,2025,10.1084/jem.20250185,https://pubmed.ncbi.nlm.nih.gov/40932625/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,41255589,The Intestinal Immune Network for IgA Production is Involved in the Development and Progression of Sepsis: A Multi-Omics Study.,2025,10.2147/jir.s548786,https://pubmed.ncbi.nlm.nih.gov/41255589/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,40592943,Increased burden of rare variants in GWAS associated genes in familial multiple sclerosis.,2025,10.1038/s41598-025-04741-7,https://pubmed.ncbi.nlm.nih.gov/40592943/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,35111166,Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55-IL6ST Gene Region in Immature Dendritic Cells.,2021,10.3389/fimmu.2021.816930,https://pubmed.ncbi.nlm.nih.gov/35111166/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,35983018,Association of ANKRD55 Gene Polymorphism with HT: A Protective Factor for Disease Susceptibility.,2022,10.1155/2022/7300796,https://pubmed.ncbi.nlm.nih.gov/35983018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,38840609,Pediatric central nervous system (CNS) neuroblastoma: A case report.,2024,10.25259/sni_794_2023,https://pubmed.ncbi.nlm.nih.gov/38840609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,38788669,Modifiable risk factors and inflammation-related proteins in polymyalgia rheumatica: genome-wide meta-analysis and Mendelian randomization.,2025,10.1093/rheumatology/keae308,https://pubmed.ncbi.nlm.nih.gov/38788669/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,36061134,Impact of Single Nucleotide Polymorphism in the ANKRD55 Gene on Occurrence and Clinical Characteristics of Rheumatoid Arthritis.,2022,10.18502/ajmb.v14i3.9833,https://pubmed.ncbi.nlm.nih.gov/36061134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,31620119,Interactome of the Autoimmune Risk Protein ANKRD55.,2019,10.3389/fimmu.2019.02067,https://pubmed.ncbi.nlm.nih.gov/31620119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,36980976,"Lack of Association of Polymorphism Located Upstream of ABCA1 (rs2472493), in FNDC3B (rs7636836), and Near ANKRD55-MAP3K1 Genes (rs61275591) in Primary Open-Angle Glaucoma Patients of Saudi Origin.",2023,10.3390/genes14030704,https://pubmed.ncbi.nlm.nih.gov/36980976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,33491520,Investigating the association of polymorphisms of ANKRD55 and MMEL1 with susceptibility to multiple sclerosis in Iranian population.,2022,10.1080/00207454.2020.1860964,https://pubmed.ncbi.nlm.nih.gov/33491520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,36303507,Adult cerebellar glioblastoma categorized into a pediatric methylation class with a unique radiological and histological appearance: illustrative case.,2022,10.3171/case2260,https://pubmed.ncbi.nlm.nih.gov/36303507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,33536079,Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation.,2021,10.1186/s40478-021-01118-5,https://pubmed.ncbi.nlm.nih.gov/33536079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,38801451,"Falls, fracture and frailty risk in multiple sclerosis: a Mendelian Randomization study to identify shared genetics.",2024,10.1007/s00774-024-01504-8,https://pubmed.ncbi.nlm.nih.gov/38801451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,31372268,The Cancer Genome Atlas dataset-based analysis of aberrantly expressed genes by GeneAnalytics in thymoma associated myasthenia gravis: focusing on T cells.,2019,10.21037/jtd.2019.06.01,https://pubmed.ncbi.nlm.nih.gov/31372268/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,33827590,Role of tumor mutation burden-related signatures in the prognosis and immune microenvironment of pancreatic ductal adenocarcinoma.,2021,10.1186/s12935-021-01900-4,https://pubmed.ncbi.nlm.nih.gov/33827590/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,35058972,Genomic Analysis of Visceral Fat Accumulation in Holstein Cows.,2021,10.3389/fgene.2021.803216,https://pubmed.ncbi.nlm.nih.gov/35058972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,28470010,Positive Association between ANKRD55 Polymorphism 7731626 and Dermatomyositis/Polymyositis with Interstitial Lung Disease in Chinese Han Population.,2017,10.1155/2017/2905987,https://pubmed.ncbi.nlm.nih.gov/28470010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,34610981,Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism.,2021,10.2337/db21-0397,https://pubmed.ncbi.nlm.nih.gov/34610981/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,27183579,Novel Insights into the Multiple Sclerosis Risk Gene ANKRD55.,2016,10.4049/jimmunol.1501205,https://pubmed.ncbi.nlm.nih.gov/27183579/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,31945409,Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease loci.,2020,10.1016/j.jaci.2019.12.910,https://pubmed.ncbi.nlm.nih.gov/31945409/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,30157932,T-cell transcriptomics from peripheral blood highlights differences between polymyositis and dermatomyositis patients.,2018,10.1186/s13075-018-1688-7,https://pubmed.ncbi.nlm.nih.gov/30157932/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD55,ENSG00000164512,Unsafe,22355377,Caucasian and Asian specific rheumatoid arthritis risk loci reveal limited replication and apparent allelic heterogeneity in north Indians.,2012,10.1371/journal.pone.0031584,https://pubmed.ncbi.nlm.nih.gov/22355377/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD62,ENSG00000181626,Unsafe,41987392,ANKRD62 Modulates NF-κB Signaling to Promote Proliferation and Migration in UCEC.,2026,10.1002/cam4.71822,https://pubmed.ncbi.nlm.nih.gov/41987392/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD7,ENSG00000106013,Unsafe,40681857,Expression of marker genes to assess the spermatogenic capacity in patients with idiopathic non-obstructive azoospermia.,2025,10.1007/s10815-025-03584-5,https://pubmed.ncbi.nlm.nih.gov/40681857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD7,ENSG00000106013,Unsafe,30289875,Identification of Key Genes and Pathways Associated with RUNX1 Mutations in Acute Myeloid Leukemia Using Bioinformatics Analysis.,2018,10.12659/msm.910916,https://pubmed.ncbi.nlm.nih.gov/30289875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD7,ENSG00000106013,Unsafe,30926877,Genome-wide association analysis suggests novel loci underlying thyroid antibodies in Hashimoto's thyroiditis.,2019,10.1038/s41598-019-41850-6,https://pubmed.ncbi.nlm.nih.gov/30926877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD7,ENSG00000106013,Unsafe,19277502,"Ankrd7, a novel gene specifically expressed in Sertoli cells and its potential roles in Sertoli cell maturation.",2009,10.1007/s10059-009-0024-0,https://pubmed.ncbi.nlm.nih.gov/19277502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD7,ENSG00000106013,Unsafe,22613542,ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior.,2012,,https://pubmed.ncbi.nlm.nih.gov/22613542/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD7,ENSG00000106013,Unsafe,30956903,Transcriptional factor regulation network and competitive endogenous RNA (ceRNA) network determining response of esophageal squamous cell carcinomas to neoadjuvant chemoradiotherapy.,2019,10.7717/peerj.6668,https://pubmed.ncbi.nlm.nih.gov/30956903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD7,ENSG00000106013,Unsafe,30581036,Genomic characterization of cervical cancer based on human papillomavirus status.,2019,10.1016/j.ygyno.2018.12.017,https://pubmed.ncbi.nlm.nih.gov/30581036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKRD7,ENSG00000106013,Unsafe,27075776,A de novo interstitial deletion of 7q31.2q31.31 identified in a girl with developmental delay and hearing loss.,2016,10.1002/ajmg.c.31488,https://pubmed.ncbi.nlm.nih.gov/27075776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,42228033,ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self-Administration via Regulating CBP-FoxO3 Complex.,2026,10.1002/advs.202522949,https://pubmed.ncbi.nlm.nih.gov/42228033/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,41564684,Lactylation-mediated degradation of ANKS1B mitigates ischemic excitotoxicity by impairing GluN2B trafficking.,2026,10.1016/j.bbrc.2026.153311,https://pubmed.ncbi.nlm.nih.gov/41564684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,41268768,Alzheimer's disease multi-ancestry genome-wide interaction and stratified study with smoking.,2025,10.1002/alz.70922,https://pubmed.ncbi.nlm.nih.gov/41268768/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,42822325,Genome-wide analysis of genetic modifiers of Crohn's disease and ulcerative colitis risk in response to tobacco smoking.,2026,10.1016/j.ebiom.2026.106486,https://pubmed.ncbi.nlm.nih.gov/42822325/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,38129387,ANKS1B encoded AIDA-1 regulates social behaviors by controlling oligodendrocyte function.,2023,10.1038/s41467-023-43438-1,https://pubmed.ncbi.nlm.nih.gov/38129387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,41255714,Complete stranded RNA profiling during early mouse gonad development.,2025,10.1093/narmme/ugaf014,https://pubmed.ncbi.nlm.nih.gov/41255714/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,38759928,AIDA-1/ANKS1B Binds to the SynGAP Family RasGAPs with High Affinity and Specificity.,2024,10.1016/j.jmb.2024.168608,https://pubmed.ncbi.nlm.nih.gov/38759928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,40631452,Comprehensive characterization of the RNA editing landscape in the human aging brains with Alzheimer's disease.,2025,10.1002/alz.70452,https://pubmed.ncbi.nlm.nih.gov/40631452/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,39764877,"The hematopoietic function, histological characteristics, and transcriptome profiling of Wanxi white geese ovary during nesting and late-laying stages.",2025,10.1016/j.psj.2025.104764,https://pubmed.ncbi.nlm.nih.gov/39764877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,37255534,Comparing synaptic proteomes across five mouse models for autism reveals converging molecular similarities including deficits in oxidative phosphorylation and Rho GTPase signaling.,2023,10.3389/fnagi.2023.1152562,https://pubmed.ncbi.nlm.nih.gov/37255534/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,38674362,Genetic Alterations in a Large Population of Italian Patients Affected by Neurodevelopmental Disorders.,2024,10.3390/genes15040427,https://pubmed.ncbi.nlm.nih.gov/38674362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,39397424,"Predicting functional outcome in ischemic stroke patients using genetic, environmental, and clinical factors: a machine learning analysis of population-based prospective cohort study.",2024,10.1093/bib/bbae487,https://pubmed.ncbi.nlm.nih.gov/39397424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,31388001,Haploinsufficiency in the ANKS1B gene encoding AIDA-1 leads to a neurodevelopmental syndrome.,2019,10.1038/s41467-019-11437-w,https://pubmed.ncbi.nlm.nih.gov/31388001/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,39194753,Genetic Variants Associated with Body Mass Index Changes in Korean Adults: The Anseong and Ansan Cohorts of the Korean Genome and Epidemiology Study.,2024,10.3390/cimb46080536,https://pubmed.ncbi.nlm.nih.gov/39194753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,31250731,The ANKS1B gene and its associated phenotypes: focus on CNS drug response.,2019,10.2217/pgs-2019-0015,https://pubmed.ncbi.nlm.nih.gov/31250731/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,40782251,hsa_circ_0099682 exacerbates the development of diabetic retinopathy by promoting pathological neoangiogenesis via the miR-125b-5p/HNRNPU axis.,2025,10.1007/s10735-025-10535-y,https://pubmed.ncbi.nlm.nih.gov/40782251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,37337823,Genome-wide association and replication studies for handedness in a Korean community-based cohort.,2023,10.1002/brb3.3121,https://pubmed.ncbi.nlm.nih.gov/37337823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,34768001,Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression.,2022,10.1016/j.ymthe.2021.11.006,https://pubmed.ncbi.nlm.nih.gov/34768001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,34988919,The Effect of Sleep Deprivation and Subsequent Recovery Period on the Synaptic Proteome of Rat Cerebral Cortex.,2022,10.1007/s12035-021-02699-x,https://pubmed.ncbi.nlm.nih.gov/34988919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,32030560,Comprehensive clinically oriented workflow for nucleotide level resolution and interpretation in prenatal diagnosis of de novo apparently balanced chromosomal translocations in their genomic landscape.,2020,10.1007/s00439-020-02121-x,https://pubmed.ncbi.nlm.nih.gov/32030560/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,28332719,rs7968606 polymorphism of ANKS1B is associated with improvement in the PANSS general score of schizophrenia caused by amisulpride.,2017,10.1002/hup.2562,https://pubmed.ncbi.nlm.nih.gov/28332719/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,28115237,Initial characterization of behavior and ketamine response in a mouse knockout of the post-synaptic effector gene Anks1b.,2017,10.1016/j.neulet.2017.01.044,https://pubmed.ncbi.nlm.nih.gov/28115237/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,19721433,Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics.,2011,10.1038/mp.2009.89,https://pubmed.ncbi.nlm.nih.gov/19721433/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,15347684,Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner.,2004,10.1074/jbc.m405329200,https://pubmed.ncbi.nlm.nih.gov/15347684/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANKS1B,ENSG00000185046,Unsafe,10490826,"EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1.",1999,10.1038/sj.onc.1202874,https://pubmed.ncbi.nlm.nih.gov/10490826/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,42618594,Anoctamin 2 deletion alters dopamine-related signaling and impairs inhibitory behavioral control in mice.,2026,10.1038/s41386-026-02525-9,https://pubmed.ncbi.nlm.nih.gov/42618594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,42792973,Deep Learning-Guided Identification and In Vivo Validation of Compact Cis-Regulatory Elements for the Zebrafish Habenula.,2026,10.3390/genes17091079,https://pubmed.ncbi.nlm.nih.gov/42792973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,41730990,Research and optimization of screening strategy for calcium-activated chloride channel modulators guided by electrophysiological characteristics.,2026,10.1038/s41598-026-39762-3,https://pubmed.ncbi.nlm.nih.gov/41730990/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,42215550,SnRNA-seq reveals seizure-induced remodelling of excitatory and inhibitory neuron populations.,2026,10.1038/s41598-026-53023-3,https://pubmed.ncbi.nlm.nih.gov/42215550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,42631516,Lytic Epstein-Barr virus infection and emerging autoantibodies precede multiple sclerosis prodrome.,2026,10.1093/brain/awag283,https://pubmed.ncbi.nlm.nih.gov/42631516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,40280711,The Role of the Ca&lt;sup&gt;2+&lt;/sup&gt;-activated Cl&lt;sup&gt;-&lt;/sup&gt; Conductance in the Membrane Potential and Light Response of Mouse Rods.,2025,10.1523/jneurosci.1920-24.2025,https://pubmed.ncbi.nlm.nih.gov/40280711/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,37403222,Intracellular Loop in the Brain Isoforms of Anoctamin 2 Channels Regulates Calcium-dependent Activation.,2023,10.5607/en22045,https://pubmed.ncbi.nlm.nih.gov/37403222/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,42792990,Multi-Omics and Machine Learning Identify Immune-Linked Gene Signatures for LUAD Stratification.,2026,10.3390/genes17091096,https://pubmed.ncbi.nlm.nih.gov/42792990/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,42195338,Polymorphism of the &lt;i&gt;FSHB&lt;/i&gt; Gene Is Associated with Endometrial Hyperplasia.,2026,10.3390/life16050782,https://pubmed.ncbi.nlm.nih.gov/42195338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,39742283,"In-depth analysis of serum antibodies against Epstein-Barr virus lifecycle proteins, and EBNA1, ANO2, GlialCAM and CRYAB peptides in patients with multiple sclerosis.",2024,10.3389/fimmu.2024.1487523,https://pubmed.ncbi.nlm.nih.gov/39742283/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,40063790,Antibody reactivity against EBNA1 and GlialCAM differentiates multiple sclerosis patients from healthy controls.,2025,10.1073/pnas.2424986122,https://pubmed.ncbi.nlm.nih.gov/40063790/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,39514389,Distinctive physiology of molecularly identified medium spiny neurons in the macaque putamen.,2024,10.1016/j.celrep.2024.114963,https://pubmed.ncbi.nlm.nih.gov/39514389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,41026459,Elucidate biomarkers and the molecular pathways associated with genetic variants that contribute to the etiology of Parkinson's disease.,2025,10.1007/s13760-025-02897-7,https://pubmed.ncbi.nlm.nih.gov/41026459/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,39167717,The Ca&lt;sup&gt;2+&lt;/sup&gt;-activated Cl&lt;sup&gt;-&lt;/sup&gt; channel TMEM16B shapes the response time course of olfactory sensory neurons.,2024,10.1113/jp286959,https://pubmed.ncbi.nlm.nih.gov/39167717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,40097179,Amplification of Olfactory Transduction Currents Implements Sparse Stimulus Encoding.,2025,10.1523/jneurosci.2008-24.2025,https://pubmed.ncbi.nlm.nih.gov/40097179/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,39257578,Enhanced and cross-reactive &lt;i&gt;in vitro&lt;/i&gt; memory B cell response against Epstein-Barr virus nuclear antigen 1 in multiple sclerosis.,2024,10.3389/fimmu.2024.1334720,https://pubmed.ncbi.nlm.nih.gov/39257578/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,31482844,TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala.,2019,10.7554/elife.47106,https://pubmed.ncbi.nlm.nih.gov/31482844/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,38825009,Modulation of TMEM16B channel activity by the calcium-activated chloride channel regulator 4 (CLCA4) in human cells.,2024,10.1016/j.jbc.2024.107432,https://pubmed.ncbi.nlm.nih.gov/38825009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,33651839,Anoctamin 2-chloride channels reduce simple spike activity and mediate inhibition at elevated calcium concentration in cerebellar Purkinje cells.,2021,10.1371/journal.pone.0247801,https://pubmed.ncbi.nlm.nih.gov/33651839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,38980270,ANO2 Genetic Variants and Anti-VEGF Treatment Response in Neovascular AMD: A Pharmacogenetic Substudy of VIEW 1 and VIEW 2.,2024,10.1167/iovs.65.8.17,https://pubmed.ncbi.nlm.nih.gov/38980270/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,41534529,Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis.,2026,10.1016/j.cell.2025.12.032,https://pubmed.ncbi.nlm.nih.gov/41534529/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,38223668,Neurobehavioral effects of the exposure to mercury vapor and methylmercury during postnatal period on mice.,2024,10.1007/s43188-023-00210-3,https://pubmed.ncbi.nlm.nih.gov/38223668/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,37802637,"Seroreactivity against lytic, latent and possible cross-reactive EBV antigens appears on average 10 years before MS induced preclinical neuroaxonal damage.",2024,10.1136/jnnp-2023-331868,https://pubmed.ncbi.nlm.nih.gov/37802637/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,39860130,Proteome-Wide Identification and Comparison of Drug Pockets for Discovering New Drug Indications and Side Effects.,2025,10.3390/molecules30020260,https://pubmed.ncbi.nlm.nih.gov/39860130/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,32517157,Targeting of Intracellular TMEM16 Proteins to the Plasma Membrane and Activation by Purinergic Signaling.,2020,10.3390/ijms21114065,https://pubmed.ncbi.nlm.nih.gov/32517157/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,38892219,Anticancer Effect of Hemin through ANO1 Inhibition in Human Prostate Cancer Cells.,2024,10.3390/ijms25116032,https://pubmed.ncbi.nlm.nih.gov/38892219/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,31375628,Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk.,2019,10.1073/pnas.1902623116,https://pubmed.ncbi.nlm.nih.gov/31375628/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,31320449,TMEM16B Calcium-Activated Chloride Channels Regulate Action Potential Firing in Lateral Septum and Aggression in Male Mice.,2019,10.1523/jneurosci.3137-18.2019,https://pubmed.ncbi.nlm.nih.gov/31320449/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,30006552,Calcium-activated chloride channels clamp odor-evoked spike activity in olfactory receptor neurons.,2018,10.1038/s41598-018-28855-3,https://pubmed.ncbi.nlm.nih.gov/30006552/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,35163502,Polymodal Control of TMEM16x Channels and Scramblases.,2022,10.3390/ijms23031580,https://pubmed.ncbi.nlm.nih.gov/35163502/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,28616863,"Contrasting effects of phosphatidylinositol 4,5-bisphosphate on cloned TMEM16A and TMEM16B channels.",2017,10.1111/bph.13913,https://pubmed.ncbi.nlm.nih.gov/28616863/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,34386330,Discovery of 4-arylthiophene-3-carboxylic acid as inhibitor of ANO1 and its effect as analgesic agent.,2021,10.1016/j.apsb.2020.11.004,https://pubmed.ncbi.nlm.nih.gov/34386330/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,28858616,Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning.,2017,10.1016/j.neuron.2017.08.010,https://pubmed.ncbi.nlm.nih.gov/28858616/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ANO2,ENSG00000047617,Unsafe,19474308,"TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals.",2009,10.1523/jneurosci.5546-08.2009,https://pubmed.ncbi.nlm.nih.gov/19474308/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,41948612,"Seizures, increased interhemispheric synchrony, altered brain transcriptomics and a leaky blood-brain barrier result from loss of &lt;i&gt;ap3b2&lt;/i&gt; in a CRISPR tadpole model of DEE48.",2026,10.3389/fneur.2026.1777738,https://pubmed.ncbi.nlm.nih.gov/41948612/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,41019034,Case Report: Subacute combined degeneration of the spinal cord mimic accompanying adaptor protein-3B2-IgG.,2025,10.3389/fimmu.2025.1598033,https://pubmed.ncbi.nlm.nih.gov/41019034/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,42816601,Single-cell profiling and genetic regulation of alternative polyadenylation in the human brain.,2026,10.1038/s41588-026-02758-w,https://pubmed.ncbi.nlm.nih.gov/42816601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,40230662,Gene variant analysis in pediatrics with early-onset epilepsy: Identification of novel variants.,2025,10.1016/j.plabm.2025.e00462,https://pubmed.ncbi.nlm.nih.gov/40230662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,34573230,Mild Cognitive Impairment in Chronic Brain Injury Associated with Serum Anti-AP3B2 Autoantibodies: Report and Literature Review.,2021,10.3390/brainsci11091208,https://pubmed.ncbi.nlm.nih.gov/34573230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,41342616,Genetic Spectrum of Negative Electroretinograms in a Predominantly Pediatric Cohort of 177 Patients.,2025,10.1167/iovs.66.15.19,https://pubmed.ncbi.nlm.nih.gov/41342616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,35508598,Plasma lncRNA LOC338963 and mRNA AP3B2 are upregulated in paraneoplastic Lambert-Eaton myasthenic syndrome.,2022,10.1002/mus.27571,https://pubmed.ncbi.nlm.nih.gov/35508598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,36356440,Novel homozygous AP3B2 mutations in four individuals with developmental and epileptic encephalopathy: A rare clinical entity.,2022,10.1016/j.clineuro.2022.107509,https://pubmed.ncbi.nlm.nih.gov/36356440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,39868839,Investigation of Genomic and Transcriptomic Risk Factors of Clopidogrel Response in African Americans.,2025,10.1002/cpt.3552,https://pubmed.ncbi.nlm.nih.gov/39868839/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,38773124,Neither alpha-synuclein fibril strain nor host murine genotype influences seeding efficacy.,2024,10.1038/s41531-024-00679-1,https://pubmed.ncbi.nlm.nih.gov/38773124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,38730308,Large-scale transcriptomic and genomic analyses reveal a novel functional gene SERPINB6 for chicken carcass traits.,2024,10.1186/s40104-024-01026-3,https://pubmed.ncbi.nlm.nih.gov/38730308/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,36360171,Codon Pattern and Compositional Constraints Determination of Genes Associated with Chronic Periodontitis.,2022,10.3390/genes13111934,https://pubmed.ncbi.nlm.nih.gov/36360171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,39615799,The ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5.,2024,10.1016/j.nbd.2024.106756,https://pubmed.ncbi.nlm.nih.gov/39615799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,31371564,Autoimmune gait disturbance accompanying adaptor protein-3B2-IgG.,2019,10.1212/wnl.0000000000008061,https://pubmed.ncbi.nlm.nih.gov/31371564/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,33005179,Identification of KIAA0513 and Other Hub Genes Associated With Alzheimer Disease Using Weighted Gene Coexpression Network Analysis.,2020,10.3389/fgene.2020.00981,https://pubmed.ncbi.nlm.nih.gov/33005179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,27889060,"Autosomal-Recessive Mutations in AP3B2, Adaptor-Related Protein Complex 3 Beta 2 Subunit, Cause an Early-Onset Epileptic Encephalopathy with Optic Atrophy.",2016,10.1016/j.ajhg.2016.10.009,https://pubmed.ncbi.nlm.nih.gov/27889060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,34042275,Blended phenotype of combination of HERC2 and AP3B2 deficiency and Angelman syndrome caused by paternal isodisomy of chromosome 15.,2021,10.1002/ajmg.a.62371,https://pubmed.ncbi.nlm.nih.gov/34042275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,34489848,Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia.,2021,10.3389/fneur.2021.683048,https://pubmed.ncbi.nlm.nih.gov/34489848/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,34580182,Neurological Autoimmunity Associated With Homer-3 Antibody: A Case Series From China.,2021,10.1212/nxi.0000000000001077,https://pubmed.ncbi.nlm.nih.gov/34580182/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,38245687,Exploration of programmed cell death-associated characteristics and immune infiltration in neonatal sepsis: new insights from bioinformatics analysis and machine learning.,2024,10.1186/s12887-024-04555-y,https://pubmed.ncbi.nlm.nih.gov/38245687/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,33988764,Cerebellar ataxia and myeloradiculopathy associated with AP3B2 antibody: a case report and literature review.,2021,10.1007/s00415-021-10496-8,https://pubmed.ncbi.nlm.nih.gov/33988764/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,31958862,Autoimmune Vestibulocerebellar Syndromes.,2020,10.1055/s-0039-3402061,https://pubmed.ncbi.nlm.nih.gov/31958862/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,26377319,"'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook.",2015,10.1186/s12974-015-0358-9,https://pubmed.ncbi.nlm.nih.gov/26377319/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,29093530,Sporadic Hirschsprung Disease: Mutational Spectrum and Novel Candidate Genes Revealed by Next-generation Sequencing.,2017,10.1038/s41598-017-14835-6,https://pubmed.ncbi.nlm.nih.gov/29093530/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,26377184,"'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC.",2015,10.1186/s12974-015-0357-x,https://pubmed.ncbi.nlm.nih.gov/26377184/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,26057447,Multiple Changes of Gene Expression and Function Reveal Genomic and Phenotypic Complexity in SLE-like Disease.,2015,10.1371/journal.pgen.1005248,https://pubmed.ncbi.nlm.nih.gov/26057447/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,26377085,"'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII.",2015,10.1186/s12974-015-0356-y,https://pubmed.ncbi.nlm.nih.gov/26377085/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,17453999,"Characterization of AP3B2_v2, a novel splice variant of human AP3B2.",2007,10.1080/10425170600842121,https://pubmed.ncbi.nlm.nih.gov/17453999/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP3B2,ENSG00000103723,Unsafe,1851215,"Antiserum from a patient with cerebellar degeneration identifies a novel protein in Purkinje cells, cortical neurons, and neuroectodermal tumors.",1991,10.1523/jneurosci.11-05-01224.1991,https://pubmed.ncbi.nlm.nih.gov/1851215/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,42597316,Splice effect of a synonymous variant in &lt;i&gt;AP4B1&lt;/i&gt;: multiomics approach establishes the diagnosis in two sisters with spastic paraplegia.,2026,10.1155/humu/8645235,https://pubmed.ncbi.nlm.nih.gov/42597316/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,41059447,Hereditary Spastic Paraplegy Associated with the AP4S1 Gene: A Case Series Highlighting Diagnostic Pitfalls and Phenotypic Variability.,2025,10.1159/000547189,https://pubmed.ncbi.nlm.nih.gov/41059447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,39865903,Heterozygous variants in AP4S1 are not associated with a neurological phenotype.,2025,10.1002/acn3.52302,https://pubmed.ncbi.nlm.nih.gov/39865903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,41230588,[Clinical characteristics and genetic study of a child with Spastic paraplegia 52 due to variant of AP4S1 gene and a literature review].,2025,10.3760/cma.j.cn511374-20241031-00572,https://pubmed.ncbi.nlm.nih.gov/41230588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,40428364,A Rare Homozygous AP4S1 Variant in Rwandan Siblings with Autosomal Recessive Hereditary Spastic Paraplegia Type 52 (SPG52).,2025,10.3390/genes16050542,https://pubmed.ncbi.nlm.nih.gov/40428364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,38715653,Autosomal Dominant Spastic Paraplegia With Dysregulation of Bowel Function Associated With Heterozygous AP4S1 Gene Mutation: Case Report.,2024,10.1212/nxg.0000000000200140,https://pubmed.ncbi.nlm.nih.gov/38715653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,42786195,Unified long-read panel for Parkinson's and repeat expansion disorders.,2026,10.1038/s41531-026-01585-4,https://pubmed.ncbi.nlm.nih.gov/42786195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,41491634,Diagnostic Utility of the ATG9A Ratio in AP-4-Associated Hereditary Spastic Paraplegia.,2026,10.1002/acn3.70308,https://pubmed.ncbi.nlm.nih.gov/41491634/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,42462372,Clinical and genetic characteristics of pediatric hereditary spastic paraplegia in the Eastern Levant.,2026,10.1016/j.ejpn.2026.07.003,https://pubmed.ncbi.nlm.nih.gov/42462372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,37767851,Ap4s1 truncation leads to axonal defects in a zebrafish model of spastic paraplegia 52.,2023,10.1002/jdn.10303,https://pubmed.ncbi.nlm.nih.gov/37767851/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,32216065,Loss of ap4s1 in zebrafish leads to neurodevelopmental defects resembling spastic paraplegia 52.,2020,10.1002/acn3.51018,https://pubmed.ncbi.nlm.nih.gov/32216065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,31660686,Utilizing RNA and outlier analysis to identify an intronic splice-altering variant in AP4S1 in a sibling pair with progressive spastic paraplegia.,2020,10.1002/humu.23939,https://pubmed.ncbi.nlm.nih.gov/31660686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,34729478,High-throughput imaging of ATG9A distribution as a diagnostic functional assay for adaptor protein complex 4-associated hereditary spastic paraplegia.,2021,10.1093/braincomms/fcab221,https://pubmed.ncbi.nlm.nih.gov/34729478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,38301078,Emerging Epidemiological Data on Rare Intellectual Disability Syndromes from Analyzing the Data of a Large Iranian Cohort.,2023,10.34172/aim.2023.29,https://pubmed.ncbi.nlm.nih.gov/38301078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,39944650,Variations in rumen microbiota and host genome impacted feed efficiency in goat breeds.,2025,10.3389/fmicb.2025.1492742,https://pubmed.ncbi.nlm.nih.gov/39944650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,30283821,AP4S1 splice-site mutation in a case of spastic paraplegia type 52 with polymicrogyria.,2018,10.1212/nxg.0000000000000273,https://pubmed.ncbi.nlm.nih.gov/30283821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,37482941,Plasma Neurofilament Light Chain Is Elevated in Adaptor Protein Complex 4-Related Hereditary Spastic Paraplegia.,2023,10.1002/mds.29524,https://pubmed.ncbi.nlm.nih.gov/37482941/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,34087981,Generation and characterization of six human induced pluripotent stem cell lines (iPSC) from three families with AP4M1-associated hereditary spastic paraplegia (SPG50).,2021,10.1016/j.scr.2021.102335,https://pubmed.ncbi.nlm.nih.gov/34087981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,25552650,"Recessive loss-of-function mutations in AP4S1 cause mild fever-sensitive seizures, developmental delay and spastic paraplegia through loss of AP-4 complex assembly.",2015,10.1093/hmg/ddu740,https://pubmed.ncbi.nlm.nih.gov/25552650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,33101357,Comprehensive Transcriptome Profiling of Dairy Goat Mammary Gland Identifies Genes and Networks Crucial for Lactation and Fatty Acid Metabolism.,2020,10.3389/fgene.2020.00878,https://pubmed.ncbi.nlm.nih.gov/33101357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AP4S1,ENSG00000100478,Unsafe,26111016,A de novo Assembly of the Common Frog (Rana temporaria) Transcriptome and Comparison of Transcription Following Exposure to Ranavirus and Batrachochytrium dendrobatidis.,2015,10.1371/journal.pone.0130500,https://pubmed.ncbi.nlm.nih.gov/26111016/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,42623522,Immune mechanisms and pathophysiology of T cell-mediated pediatric acute liver failure (TC-PALF).,2026,10.1097/hc9.0000000000001033,https://pubmed.ncbi.nlm.nih.gov/42623522/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,41921202,CD8 TRM-like T cells expressing perforin and IFN-γ define a pediatric activated T-cell acute liver failure endotype.,2026,10.1097/hc9.0000000000000926,https://pubmed.ncbi.nlm.nih.gov/41921202/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,41642676,Successful Heat Stroke-Induced Pediatric Acute Liver Failure Treatment With N-Acetylcysteine Case Report.,2026,10.1097/cce.0000000000001371,https://pubmed.ncbi.nlm.nih.gov/41642676/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,42703783,Identification of human leukocyte antigen class I risk alleles and enriched T cell receptor groups in activated T cell pediatric acute liver failure.,2026,10.1002/jpn3.70573,https://pubmed.ncbi.nlm.nih.gov/42703783/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,40911670,&lt;i&gt;Aplf/Dna2&lt;/i&gt; variants drive chromosomal fission and accelerate speciation in zokors.,2025,10.1126/sciadv.adt2282,https://pubmed.ncbi.nlm.nih.gov/40911670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,42559730,CD68 and F4/80 Markers Demonstrate Inflammatory Synergism Between Apical Periodontitis and Liver Fibrosis in Wistar Rats.,2026,10.1111/iej.70244,https://pubmed.ncbi.nlm.nih.gov/42559730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,42514993,Fulminant Hepatitis Due to Enterovirus E25 Systemic Infection in a Pediatric Patient.,2026,10.3390/pathogens15070666,https://pubmed.ncbi.nlm.nih.gov/42514993/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,42500101,Percutaneous Aponeurotomy and Lipofilling in Complex Periorbital Scar Revision.,2026,10.1002/wjo2.70115,https://pubmed.ncbi.nlm.nih.gov/42500101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,42422268,Pediatric acute liver failure in a child with arsenic toxicity and underlying rotor syndrome.,2026,10.1093/omcr/omag111,https://pubmed.ncbi.nlm.nih.gov/42422268/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,42275577,"The incidence, frequency of late liver-related complications, and transplant likelihood in pediatric acute liver failure in Californian children.",2026,10.1097/hc9.0000000000000968,https://pubmed.ncbi.nlm.nih.gov/42275577/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,41524117,"From crown to cosmetics: Exploring the efficacy of an upcycled pineapple biopolymer in sustainable skincare, suncare and hair care applications.",2026,10.1111/ics.70071,https://pubmed.ncbi.nlm.nih.gov/41524117/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,42374355,Liver transplant for paediatric acute liver failure: insights from a newly established paediatric liver transplant program in a developing country.,2026,10.1186/s12887-026-07252-0,https://pubmed.ncbi.nlm.nih.gov/42374355/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,42493812,Therapeutic Plasma Exchange as a Bridge to Spontaneous Recovery in Pediatric Acute Liver Failure in a Resource-Limited Setting: A Prospective Single-Center Experience in Morocco.,2026,10.1002/jca.70159,https://pubmed.ncbi.nlm.nih.gov/42493812/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,41441974,Utility of transcranial Doppler and reversed jugular venous saturations for neuromonitoring in children with acute liver failure.,2025,10.1007/s00431-025-06697-2,https://pubmed.ncbi.nlm.nih.gov/41441974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,41807995,Reduced eccDNA content in idiopathic asthenozoospermia sperm is associated with compromised DNA repair capacity and elevated DNA damage.,2026,10.1186/s11658-026-00857-4,https://pubmed.ncbi.nlm.nih.gov/41807995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,40833444,Association of lactate-albumin ratio with native liver survival in paediatric acute liver failure: a 10-year retrospective study.,2025,10.1080/07853890.2025.2549135,https://pubmed.ncbi.nlm.nih.gov/40833444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,39621058,Missense variants in the TRPM7 α-kinase domain are associated with recurrent pediatric acute liver failure.,2024,10.1097/hc9.0000000000000598,https://pubmed.ncbi.nlm.nih.gov/39621058/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,39384105,Nuclear localization of APLF facilitates breast cancer metastasis.,2025,10.1016/j.bbadis.2024.167537,https://pubmed.ncbi.nlm.nih.gov/39384105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,40809145,"Intertwined roles for GDF-15, HMGB1, and MIG/CXCL9 in Pediatric Acute Liver Failure.",2024,10.3389/fsysb.2024.1470000,https://pubmed.ncbi.nlm.nih.gov/40809145/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,41245031,"No apparent increase in cases of severe acute hepatitis of unknown etiology with fulminant liver failure in children in Germany, 2022.",2025,10.1002/jpr3.70083,https://pubmed.ncbi.nlm.nih.gov/41245031/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,41693417,Early immunosuppression therapy improves outcomes in CD8+ T-cell activated paediatric acute liver failure and hepatitis.,2026,10.1002/jpn3.70374,https://pubmed.ncbi.nlm.nih.gov/41693417/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,40033216,Preliminary experience of combined dual plasma molecular adsorption system and plasma exchange in pediatric acute liver failure: a retrospective case series.,2025,10.1186/s12887-025-05520-z,https://pubmed.ncbi.nlm.nih.gov/40033216/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,41756377,An interpretable machine learning model with SHAP explanations predicts spontaneous bleeding in pediatric acute liver failure.,2026,10.3389/fmed.2026.1727411,https://pubmed.ncbi.nlm.nih.gov/41756377/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,39278359,Systemic T-cell activation and IFN-γ activity in indeterminate severe hepatitis are reminiscent of hemophagocytic lymphohistiocytosis: Implications for T-cell- and IFN-γ-directed therapies.,2025,10.1016/j.jaci.2024.08.029,https://pubmed.ncbi.nlm.nih.gov/39278359/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,38936769,Identification of pediatric activated T-cell hepatitis using clinical immune studies.,2024,10.1016/j.clinre.2024.102407,https://pubmed.ncbi.nlm.nih.gov/38936769/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,39292794,Minimally Invasive Surgery for Posterior Atlantoaxial Lateral Mass Joint Fusion (MIS-PALF): A Muscle-Sparing Procedure for Atlantoaxial Instability or Dislocation.,2024,10.2106/jbjs.23.01464,https://pubmed.ncbi.nlm.nih.gov/39292794/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,38520407,APLF facilitates interstrand DNA crosslink repair and replication fork protection to confer cisplatin resistance.,2024,10.1093/nar/gkae211,https://pubmed.ncbi.nlm.nih.gov/38520407/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APLF,ENSG00000169621,Unsafe,39937316,Molecular adsorbent recirculating system (MARS®) and continuous renal replacement therapy for the treatment of paediatric acute liver failure - two-centre retrospective cohort study.,2025,10.1007/s00431-025-06013-y,https://pubmed.ncbi.nlm.nih.gov/39937316/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,42884106,"Pan-Cancer APOBEC Mutagenesis, Immune Microenvironment, and Clinical Outcome: A Comprehensive Multi-Omics Analysis of All Ten Family Members Across 9653 TCGA Tumors.",2026,10.3390/ijms27198864,https://pubmed.ncbi.nlm.nih.gov/42884106/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,41494272,APOBEC3F restricts PRRSV replication through its CD2 domain and interaction with host antiviral proteins.,2026,10.1016/j.vetmic.2026.110872,https://pubmed.ncbi.nlm.nih.gov/41494272/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,41795000,Rationally and in silico guided APOBEC3F-directed CBE for enhanced PDAC genetic therapy.,2026,10.1038/s42003-026-09770-0,https://pubmed.ncbi.nlm.nih.gov/41795000/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,41559128,The significance of immunogenic cell death related prognostic gene markers in colorectal cancer prognosis and antitumor immunity.,2026,10.1038/s41598-025-33862-2,https://pubmed.ncbi.nlm.nih.gov/41559128/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,39714157,Variability in HIV-1 transmitted/founder virus susceptibility to combined APOBEC3F and APOBEC3G host restriction.,2025,10.1128/jvi.01606-24,https://pubmed.ncbi.nlm.nih.gov/39714157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,39817775,"Erratum for Ara et al., ""Mechanism of Enhanced HIV Restriction by Virion Coencapsidated Cytidine Deaminases APOBEC3F and APOBEC3G"".",2025,10.1128/jvi.02204-24,https://pubmed.ncbi.nlm.nih.gov/39817775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,40191862,Comprehensive Analysis of Roles of APOBEC3 Gene Family in Clear Cell Renal Cell Carcinoma.,2025,10.56434/j.arch.esp.urol.20257802.26,https://pubmed.ncbi.nlm.nih.gov/40191862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,35261799,APOBEC3F expression in triple-negative breast cancer is associated with tumor microenvironment infiltration and activation of cancer immunity and improved survival.,2022,,https://pubmed.ncbi.nlm.nih.gov/35261799/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,36851677,Stability of APOBEC3F in the Presence of the APOBEC3 Antagonist HIV-1 Vif Increases at the Expense of Co-Expressed APOBEC3H Haplotype I.,2023,10.3390/v15020463,https://pubmed.ncbi.nlm.nih.gov/36851677/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,40608562,SARS-CoV-2 structural proteins affect the expression of &lt;i&gt;IL-8&lt;/i&gt; and &lt;i&gt;TNF-α&lt;/i&gt; cytokines and &lt;i&gt;APOBEC&lt;/i&gt; genes in human lung A549 and liver Huh-7 cells.,2025,10.2478/acph-2025-0024,https://pubmed.ncbi.nlm.nih.gov/40608562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,40250960,Purification of enzymatically active APOBEC proteins from an insect cell expression system.,2025,10.1016/bs.mie.2024.11.035,https://pubmed.ncbi.nlm.nih.gov/40250960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,37224627,APOBEC3F Is a Mutational Driver of the Human Monkeypox Virus Identified in the 2022 Outbreak.,2023,10.1093/infdis/jiad165,https://pubmed.ncbi.nlm.nih.gov/37224627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,34992692,Discovering novel mechanisms of taxane resistance in human breast cancer by whole-exome sequencing.,2022,10.3892/ol.2021.13178,https://pubmed.ncbi.nlm.nih.gov/34992692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,37305390,Transcriptome analysis reveals tumor antigen and immune subtypes of melanoma.,2023,10.32604/or.2023.029274,https://pubmed.ncbi.nlm.nih.gov/37305390/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,31776266,An Alu Element Insertion in Intron 1 Results in Aberrant Alternative Splicing of APOBEC3G Pre-mRNA in Northern Pig-Tailed Macaques (Macaca leonina) That May Reduce APOBEC3G-Mediated Hypermutation Pressure on HIV-1.,2020,10.1128/jvi.01722-19,https://pubmed.ncbi.nlm.nih.gov/31776266/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,38548018,Protein Interaction Map of APOBEC3 Enzyme Family Reveals Deamination-Independent Role in Cellular Function.,2024,10.1016/j.mcpro.2024.100755,https://pubmed.ncbi.nlm.nih.gov/38548018/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,36627271,Antiretroviral APOBEC3 cytidine deaminases alter HIV-1 provirus integration site profiles.,2023,10.1038/s41467-022-35379-y,https://pubmed.ncbi.nlm.nih.gov/36627271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,34132575,APOBEC3F Constitutes a Barrier to Successful Cross-Species Transmission of Simian Immunodeficiency Virus SIVsmm to Humans.,2021,10.1128/jvi.00808-21,https://pubmed.ncbi.nlm.nih.gov/34132575/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,38043095,Defining Distinct RNA-Protein Interactomes of SARS-CoV-2 Genomic and Subgenomic RNAs.,2024,10.1021/acs.jproteome.3c00506,https://pubmed.ncbi.nlm.nih.gov/38043095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,31025011,Role of co-expressed APOBEC3F and APOBEC3G in inducing HIV-1 drug resistance.,2019,10.1016/j.heliyon.2019.e01498,https://pubmed.ncbi.nlm.nih.gov/31025011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,34774569,"Differential Activity of APOBEC3F, APOBEC3G, and APOBEC3H in the Restriction of HIV-2.",2022,10.1016/j.jmb.2021.167355,https://pubmed.ncbi.nlm.nih.gov/34774569/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,33818775,Transcriptional signatures associated with rubella virus-specific humoral immunity after a third dose of MMR vaccine in women of childbearing age.,2021,10.1002/eji.202049054,https://pubmed.ncbi.nlm.nih.gov/33818775/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,35950859,Dominant Negative Mutants of Human Immunodeficiency Virus Type 1 Viral Infectivity Factor (Vif) Disrupt Core-Binding Factor Beta-Vif Interaction.,2022,10.1128/jvi.00555-22,https://pubmed.ncbi.nlm.nih.gov/35950859/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,32913367,A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans.,2020,10.1371/journal.ppat.1008812,https://pubmed.ncbi.nlm.nih.gov/32913367/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,32719674,Methadone Inhibits Viral Restriction Factors and Facilitates HIV Infection in Macrophages.,2020,10.3389/fimmu.2020.01253,https://pubmed.ncbi.nlm.nih.gov/32719674/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,33510734,Dual Functionality of HIV-1 Vif in APOBEC3 Counteraction and Cell Cycle Arrest.,2020,10.3389/fmicb.2020.622012,https://pubmed.ncbi.nlm.nih.gov/33510734/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,35957953,APOBEC3 selects V179I in HIV-1 reverse transcriptase to provide selective advantage for non-nucleoside reverse transcriptase inhibitor-resistant mutants.,2022,10.3389/fviro.2022.919825,https://pubmed.ncbi.nlm.nih.gov/35957953/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,28893290,Evasion of adaptive immunity by HIV through the action of host APOBEC3G/F enzymes.,2017,10.1186/s12981-017-0173-8,https://pubmed.ncbi.nlm.nih.gov/28893290/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,25142588,APOBEC3F determinants of HIV-1 Vif sensitivity.,2014,10.1128/jvi.02362-14,https://pubmed.ncbi.nlm.nih.gov/25142588/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,26628363,The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches.,2015,10.1016/j.celrep.2015.10.067,https://pubmed.ncbi.nlm.nih.gov/26628363/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,24503066,Catalytic activity of APOBEC3F is required for efficient restriction of Vif-deficient human immunodeficiency virus.,2014,10.1016/j.virol.2013.11.041,https://pubmed.ncbi.nlm.nih.gov/24503066/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,25165112,"Possible footprints of APOBEC3F and/or other APOBEC3 deaminases, but not APOBEC3G, on HIV-1 from patients with acute/early and chronic infections.",2014,10.1128/jvi.01460-14,https://pubmed.ncbi.nlm.nih.gov/25165112/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,25330146,APOBEC3D and APOBEC3F potently promote HIV-1 diversification and evolution in humanized mouse model.,2014,10.1371/journal.ppat.1004453,https://pubmed.ncbi.nlm.nih.gov/25330146/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,20308164,Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction.,2010,10.1093/nar/gkq174,https://pubmed.ncbi.nlm.nih.gov/20308164/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,15152192,"A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins.",2004,10.1038/sj.emboj.7600246,https://pubmed.ncbi.nlm.nih.gov/15152192/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC3F,ENSG00000128394,Unsafe,11863358,An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.,2002,10.1006/geno.2002.6718,https://pubmed.ncbi.nlm.nih.gov/11863358/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC4,ENSG00000173627,Unsafe,38976757,The cytidine deaminase APOBEC3A regulates nucleolar function to promote cell growth and ribosome biogenesis.,2024,10.1371/journal.pbio.3002718,https://pubmed.ncbi.nlm.nih.gov/38976757/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC4,ENSG00000173627,Unsafe,34276680,AID and APOBECs as Multifaceted Intrinsic Virus-Restricting Factors: Emerging Concepts in the Light of COVID-19.,2021,10.3389/fimmu.2021.690416,https://pubmed.ncbi.nlm.nih.gov/34276680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC4,ENSG00000173627,Unsafe,34234167,"Genomic epidemiology of SARS-CoV-2 in the UAE reveals novel virus mutation, patterns of co-infection and tissue specific host immune response.",2021,10.1038/s41598-021-92851-3,https://pubmed.ncbi.nlm.nih.gov/34234167/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC4,ENSG00000173627,Unsafe,27249646,APOBEC4 Enhances the Replication of HIV-1.,2016,10.1371/journal.pone.0155422,https://pubmed.ncbi.nlm.nih.gov/27249646/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC4,ENSG00000173627,Unsafe,34659891,Effect of APOBEC3A functional polymorphism on renal cell carcinoma is influenced by tumor necrosis factor-α and transcriptional repressor ETS1.,2021,,https://pubmed.ncbi.nlm.nih.gov/34659891/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC4,ENSG00000173627,Unsafe,31991164,Characterization and functional analysis of chicken APOBEC4.,2020,10.1016/j.dci.2020.103631,https://pubmed.ncbi.nlm.nih.gov/31991164/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC4,ENSG00000173627,Unsafe,25818029,APOBECs and virus restriction.,2015,10.1016/j.virol.2015.03.012,https://pubmed.ncbi.nlm.nih.gov/25818029/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC4,ENSG00000173627,Unsafe,26459911,The eQTL-missense polymorphisms of APOBEC3H are associated with lung cancer risk in a Han Chinese population.,2015,10.1038/srep14969,https://pubmed.ncbi.nlm.nih.gov/26459911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC4,ENSG00000173627,Unsafe,25904160,APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma.,2015,10.1038/ncomms7997,https://pubmed.ncbi.nlm.nih.gov/25904160/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC4,ENSG00000173627,Unsafe,16082223,"APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis.",2005,10.4161/cc.4.9.1994,https://pubmed.ncbi.nlm.nih.gov/16082223/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC4,ENSG00000173627,Unsafe,21568845,Mutator effects and mutation signatures of editing deaminases produced in bacteria and yeast.,2011,10.1134/s0006297911010135,https://pubmed.ncbi.nlm.nih.gov/21568845/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC4,ENSG00000173627,Unsafe,29555751,Diversification of AID/APOBEC-like deaminases in metazoa: multiplicity of clades and widespread roles in immunity.,2018,10.1073/pnas.1720897115,https://pubmed.ncbi.nlm.nih.gov/29555751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC4,ENSG00000173627,Unsafe,16580072,HIV-1 Vif protein blocks the cytidine deaminase activity of B-cell specific AID in E. coli by a similar mechanism of action.,2007,10.1016/j.molimm.2006.02.005,https://pubmed.ncbi.nlm.nih.gov/16580072/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
APOBEC4,ENSG00000173627,Unsafe,19136562,Dissecting APOBEC3G substrate specificity by nucleoside analog interference.,2009,10.1074/jbc.m807258200,https://pubmed.ncbi.nlm.nih.gov/19136562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42823969,The role of NEDD4-mediated ubiquitination of AQP5 in allergic rhinitis: implications for nasal mucosal barrier function.,2026,10.3389/fimmu.2026.1908261,https://pubmed.ncbi.nlm.nih.gov/42823969/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42574300,Aquaporin 5 and Nuclear Factor Erythroid 2-Related Factor 2 Upregulation in Tumor and Stroma Is Associated with Poor Pathological Complete Response to Neoadjuvant Chemotherapy in Breast Cancer.,2026,10.1159/mpp/adpag003,https://pubmed.ncbi.nlm.nih.gov/42574300/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42882241,Kidney-Based Molecular Diagnostics of Freshwater Drowning: Comparative Evaluation of SP-A2 and AQP5 in an Animal Model.,2026,10.3390/diagnostics16193086,https://pubmed.ncbi.nlm.nih.gov/42882241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42900221,Tissue expression of aquaporin-5 and cytochrome c as potential forensic biomarkers of drowning: Evidence from an experimental rat model.,2026,10.1007/s00114-026-02187-z,https://pubmed.ncbi.nlm.nih.gov/42900221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,41826647,NRIP1 disrupts ERα signal in Sjögren's disease via AQP5 suppression and MYC-driven salivary dysfunction.,2026,10.1038/s12276-026-01671-w,https://pubmed.ncbi.nlm.nih.gov/41826647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42236212,Expression of aquaporin 3 in squamous cell carcinoma in dogs and cats.,2026,10.1292/jvms.26-0137,https://pubmed.ncbi.nlm.nih.gov/42236212/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42687517,The expression of stemness markers in organoids according to histological subtypes of gastric cancer.,2026,10.14216/kjco.26404,https://pubmed.ncbi.nlm.nih.gov/42687517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42374058,Association of AQP5 gene variants and mRNA expression with caries severity in a dental practice cohort: a randomized trial.,2026,10.1038/s41598-026-59514-7,https://pubmed.ncbi.nlm.nih.gov/42374058/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42092476,Mechanism exploration of Jiajian Yiguan decoction in treating Sjögren's syndrome.,2026,10.1016/j.jep.2026.121813,https://pubmed.ncbi.nlm.nih.gov/42092476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,41184862,CLIP2: a novel functional player in AQP5 trafficking dynamics and implications for Sjögren's disease.,2025,10.1186/s12964-025-02476-6,https://pubmed.ncbi.nlm.nih.gov/41184862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,41601667,Berberine augments the secretory function of salivary gland in homeostasis and after radiation exposure.,2025,10.3389/fimmu.2025.1685137,https://pubmed.ncbi.nlm.nih.gov/41601667/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42712008,Expression of Mineral and Urea Transport-Related Genes in the Salivary Glands and Ruminal Epithelium of Young Goats Fed Nitrogen- and/or Calcium-Reduced Diets.,2026,10.1111/jpn.70110,https://pubmed.ncbi.nlm.nih.gov/42712008/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42144955,Aquaporin-3 and aquaporin-5 impact the development of pancreatic ductal adenocarcinoma spheroids.,2026,10.1002/2211-5463.70270,https://pubmed.ncbi.nlm.nih.gov/42144955/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42143071,LncRNA TUG1 mitigates sepsis-induced acute lung injury via a ceRNA network regulating the CALM1/PRKG1/RYR3/AQP5 axis.,2026,10.1038/s41598-026-51003-1,https://pubmed.ncbi.nlm.nih.gov/42143071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,41867109,Synergistic effect of combined hyperthermia and radiotherapy mediated by AQP5 reduction in pancreatic cancer.,2026,10.1080/02656736.2026.2644451,https://pubmed.ncbi.nlm.nih.gov/41867109/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,40961922,Targeting AQP5-mediated arginine deprivation in gastric cancer stem cells restores NK cell anti-tumor immunity.,2025,10.1016/j.xcrm.2025.102333,https://pubmed.ncbi.nlm.nih.gov/40961922/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,40976709,"Aquaporin-1, aquaporin-3 and aquaporin-5 differentially modulate cell biophysical and biomechanical properties, impacting cell stiffness and cell-cell adhesion.",2026,10.1111/febs.70269,https://pubmed.ncbi.nlm.nih.gov/40976709/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42057406,Polygonatum sibiricum Alleviates Salivary Gland Dysfunction in Sjögren's Syndrome via CHRM3/AQP5 Axis Potentiation.,2026,10.1055/a-2867-4341,https://pubmed.ncbi.nlm.nih.gov/42057406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42262824,Urine Aquaporin-5 a biomarker in diabetic nephropathy.,2026,10.4103/sjkdt.sjkdt_647_20,https://pubmed.ncbi.nlm.nih.gov/42262824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,40760228,Relationship between AQP5 and chemotherapy resistance in colorectal cancer cells and its mechanism.,2025,10.1007/s12672-025-03193-9,https://pubmed.ncbi.nlm.nih.gov/40760228/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,41270250,Sjögren Syndrome Candidate Autoantigen AQP5 Triggers AQP4 CNS Autoimmunity Through Self-Antigen Mimicry.,2026,10.1212/nxi.0000000000200517,https://pubmed.ncbi.nlm.nih.gov/41270250/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,40951698,"Shatai Heji Mitigates Sjögren Disease-Induced Xerostomia by Regulating AQP5, NF-κB, and p38 MAPK Signaling Pathwaysaff.",2025,10.2147/dddt.s526278,https://pubmed.ncbi.nlm.nih.gov/40951698/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,40880648,Polydatin ameliorates hyperhidrosis by targeting Aqp5 in a mouse model.,2025,10.3389/fphar.2025.1589143,https://pubmed.ncbi.nlm.nih.gov/40880648/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,41332187,TLR7 responses to nucleosides drive sialadenitis in Slc29a3-deficient mice.,2026,10.1093/intimm/dxaf073,https://pubmed.ncbi.nlm.nih.gov/41332187/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42333009,Microbial Fermentation Reduces Xerostomia-Related 5-Demethylnobiletin in Aurantii Fructus: A Chromatographic and Pharmacological Evaluation.,2026,10.1002/bmc.70500,https://pubmed.ncbi.nlm.nih.gov/42333009/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,41977205,"The Multifunctional Roles of Aquaporins in Tumors: Focusing on Metabolism, Migration, and Regulation of the Tumor Microenvironment.",2026,10.3390/ijms27073016,https://pubmed.ncbi.nlm.nih.gov/41977205/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42769159,Tripterygium glycosides and mesenchymal stem cells combination alleviated Sjögren's syndrome Features in mice and modulated the GRO-α/CXCR2 axis.,2026,10.62347/hfyo1240,https://pubmed.ncbi.nlm.nih.gov/42769159/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42510603,"Lute-Gen&lt;sup&gt;®&lt;/sup&gt; Alleviates Dry Eye Disease and Modulates Nrf2/HO-1, TLR4/NF-κB/MAPK Signaling, and Aquaporin-Mediated Tear Homeostasis.",2026,10.3390/antiox15070872,https://pubmed.ncbi.nlm.nih.gov/42510603/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42465742,Aquaporin-5-specific heavy chain VDJ knock-in (A5H) mice reveal molecular mimicry-driven initiation and diversification of autoreactive B-cell responses.,2026,10.3389/fimmu.2026.1866158,https://pubmed.ncbi.nlm.nih.gov/42465742/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42421105,Effects and mechanism of carrier-free self-assembled nanoparticles of natural products in attenuating pulmonary edema.,2026,10.1186/s12951-026-04777-5,https://pubmed.ncbi.nlm.nih.gov/42421105/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,40244097,The Influence of AQP5 on the Response to Hydrogen Peroxide in Breast Cancer Cell Lines.,2025,10.3390/ijms26073243,https://pubmed.ncbi.nlm.nih.gov/40244097/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42209658,Erdosteine modulates surfactant-associated markers and preserves lung architecture in a preterm rat model compared with dexamethasone and betamethasone.,2026,10.1038/s41598-026-54256-y,https://pubmed.ncbi.nlm.nih.gov/42209658/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,42266366,Protective effects of multi-strain probiotics against polystyrene nanoplastic-induced parotid gland toxicity: role of NRF2/HO-1 and NF-κB pathways.,2026,10.3389/fphar.2026.1824052,https://pubmed.ncbi.nlm.nih.gov/42266366/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,41921445,Comprehensive Immunophenotypic Profiling and Prognostic Value in Salivary Gland Mucoepidermoid Carcinoma.,2026,10.1016/j.identj.2026.109516,https://pubmed.ncbi.nlm.nih.gov/41921445/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AQP5,ENSG00000161798,Unsafe,23473857,Immunolocalization and translocation of aquaporin-5 water channel in sweat glands.,2013,10.1016/j.jdermsci.2013.01.013,https://pubmed.ncbi.nlm.nih.gov/23473857/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,42255913,A novel homozygous &lt;i&gt;ARFGEF2&lt;/i&gt; splice-site variant causing periventricular nodular heterotopia with microcephaly.,2026,10.3389/fped.2026.1758158,https://pubmed.ncbi.nlm.nih.gov/42255913/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,42312793,A conserved Arf-GEF modulates axonal integrity through RAB-35 by altering neuron-epidermal attachment.,2026,10.1242/jcs.264565,https://pubmed.ncbi.nlm.nih.gov/42312793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,42200925,ARFGEF2-Related Periventricular Nodular Heterotopia: A Case Report and Literature Review.,2026,10.3390/neurosci7030063,https://pubmed.ncbi.nlm.nih.gov/42200925/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,40208939,Arf1 and ARFGEF2/Sec71 control neuroblast polarity by anchoring nonmuscle myosin II.,2025,10.1073/pnas.2419468122,https://pubmed.ncbi.nlm.nih.gov/40208939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,42344540,Role of thromboelastography in risk stratifying patients with traumatic brain injury on prehospital antiplatelet agents.,2026,10.1136/tsaco-2025-002013,https://pubmed.ncbi.nlm.nih.gov/42344540/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,40902389,"Applying brain injury guidelines to patients with traumatic brain injury: A contemporary, consecutive series.",2025,10.1016/j.jocn.2025.111605,https://pubmed.ncbi.nlm.nih.gov/40902389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,39889522,Evaluating the brain injury guidelines (BIG) in an Australian trauma centre: A retrospective cohort analysis.,2025,10.1016/j.jocn.2025.111092,https://pubmed.ncbi.nlm.nih.gov/39889522/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,39994934,Applying an updated brain injury guideline classification to interhospital transfer of patients with traumatic brain injury: Who benefits most?,2025,10.1016/j.clineuro.2024.108704,https://pubmed.ncbi.nlm.nih.gov/39994934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,41970998,Identification of novel genomic variants in diabetic nephropathy patients using whole-exome sequencing: a pilot investigation.,2026,10.3389/fendo.2026.1798640,https://pubmed.ncbi.nlm.nih.gov/41970998/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,38879142,The lipid flippase ATP8A1 regulates the recruitment of ARF effectors to the trans-Golgi Network.,2024,10.1016/j.abb.2024.110049,https://pubmed.ncbi.nlm.nih.gov/38879142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,42160472,"Opinion Leadership among Nurses in Public Debate: Moral Conviction, Credibility, and Collective Support.",2026,10.1177/15271544261444730,https://pubmed.ncbi.nlm.nih.gov/42160472/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,40834594,Whole genome resequencing reveals genetic markers for plumage colour in Jingyuan Chicken.,2025,10.1016/j.psj.2025.105666,https://pubmed.ncbi.nlm.nih.gov/40834594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,29455446,BIG2-ARF1-RhoA-mDia1 Signaling Regulates Dendritic Golgi Polarization in Hippocampal Neurons.,2018,10.1007/s12035-018-0954-7,https://pubmed.ncbi.nlm.nih.gov/29455446/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,38250258,Unraveling shared susceptibility loci and Mendelian genetic associations linking educational attainment with multiple neuropsychiatric disorders.,2023,10.3389/fpsyt.2023.1303430,https://pubmed.ncbi.nlm.nih.gov/38250258/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,39462795,Recognisable Neuroradiological Findings in Five Neurogenetic Disorders.,2025,10.1111/cge.14637,https://pubmed.ncbi.nlm.nih.gov/39462795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,38647147,A Novel Macroglossia Severity Index for Beckwith-Wiedemann Syndrome.,2025,10.1097/sla.0000000000006301,https://pubmed.ncbi.nlm.nih.gov/38647147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,39041483,Diagnostic utility of Brain Injury Guidelines (BIG): systematic review and meta-analysis for prediction of neurosurgical intervention in traumatic brain injury.,2024,10.1080/02699052.2024.2375593,https://pubmed.ncbi.nlm.nih.gov/39041483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,31199673,Involvement of BIG1 and BIG2 in regulating VEGF expression and angiogenesis.,2019,10.1096/fj.201900342rr,https://pubmed.ncbi.nlm.nih.gov/31199673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,37363990,Mutant KRAS Mediates circARFGEF2 Biogenesis to Promote Lymphatic Metastasis of Pancreatic Ductal Adenocarcinoma.,2023,10.1158/0008-5472.can-22-3997,https://pubmed.ncbi.nlm.nih.gov/37363990/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,34133258,Retrospective analysis of small intracranial hemorrhage in trauma: Is acute care surgery team management alone safe?,2021,10.1080/02699052.2021.1920052,https://pubmed.ncbi.nlm.nih.gov/34133258/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,37354568,N6-methyladenosine methylation mediates non-coding RNAs modification in microplastic-induced cardiac injury.,2023,10.1016/j.ecoenv.2023.115174,https://pubmed.ncbi.nlm.nih.gov/37354568/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,37310797,Quality of Life in Male Breast Cancer: Prospective Study of the International Male Breast Cancer Program (EORTC10085/TBCRC029/BIG2-07/NABCG).,2023,10.1093/oncolo/oyad152,https://pubmed.ncbi.nlm.nih.gov/37310797/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,35659227,"Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes.",2022,10.1186/s12920-022-01281-1,https://pubmed.ncbi.nlm.nih.gov/35659227/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,22956851,Brefeldin A-inhibited guanine exchange factor 2 regulates filamin A phosphorylation and neuronal migration.,2012,10.1523/jneurosci.1063-12.2012,https://pubmed.ncbi.nlm.nih.gov/22956851/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,32203207,Long-term cardiac outcomes of patients with HER2-positive breast cancer treated in the adjuvant lapatinib and/or trastuzumab Treatment Optimization Trial.,2020,10.1038/s41416-020-0786-x,https://pubmed.ncbi.nlm.nih.gov/32203207/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,27162341,Enhancement of β-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals.,2016,10.1073/pnas.1601918113,https://pubmed.ncbi.nlm.nih.gov/27162341/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,27838311,Strain and sex based characterization of behavioral expressions in non-induced compulsive-like mice.,2017,10.1016/j.physbeh.2016.11.002,https://pubmed.ncbi.nlm.nih.gov/27838311/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,29112323,Identification of GBF1 as a cellular factor required for hepatitis E virus RNA replication.,2018,10.1111/cmi.12804,https://pubmed.ncbi.nlm.nih.gov/29112323/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,20360857,Specific functions of BIG1 and BIG2 in endomembrane organization.,2010,10.1371/journal.pone.0009898,https://pubmed.ncbi.nlm.nih.gov/20360857/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,30683929,Multiple genomic copy number variants associated with periventricular nodular heterotopia indicate extreme genetic heterogeneity.,2019,10.1038/s41431-019-0335-3,https://pubmed.ncbi.nlm.nih.gov/30683929/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,25778467,Genetic modifiers of response to glucose-insulin-potassium (GIK) infusion in acute coronary syndromes and associations with clinical outcomes in the IMMEDIATE trial.,2015,10.1038/tpj.2015.10,https://pubmed.ncbi.nlm.nih.gov/25778467/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,27155012,Elucidation of tonic and activated B-cell receptor signaling in Burkitt's lymphoma provides insights into regulation of cell survival.,2016,10.1073/pnas.1601053113,https://pubmed.ncbi.nlm.nih.gov/27155012/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,12606707,Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506.,2003,10.1073/pnas.2628047100,https://pubmed.ncbi.nlm.nih.gov/12606707/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,16467138,Effect of protein kinase A on accumulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) in HepG2 cell nuclei.,2006,10.1073/pnas.0510571103,https://pubmed.ncbi.nlm.nih.gov/16467138/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,22379090,Valosin-containing protein (VCP/p97) is required for poliovirus replication and is involved in cellular protein secretion pathway in poliovirus infection.,2012,10.1128/jvi.00114-12,https://pubmed.ncbi.nlm.nih.gov/22379090/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARFGEF2,ENSG00000124198,Unsafe,19740986,"GBF1, a guanine nucleotide exchange factor for Arf, is crucial for coxsackievirus B3 RNA replication.",2009,10.1128/jvi.01244-09,https://pubmed.ncbi.nlm.nih.gov/19740986/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,41674985,ARHGAP11A affects lung adenocarcinoma (LUAD) and pancreatic adenocarcinoma (PAAD) progression by regulating FAM83A.,2026,10.21037/tcr-2025-1961,https://pubmed.ncbi.nlm.nih.gov/41674985/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,41136949,"ARHGAP11A, a member of Rho GTPase activating protein family, as a prognostic biomarker linked to DNA damage response across pan-cancer.",2025,10.1186/s12885-025-15106-8,https://pubmed.ncbi.nlm.nih.gov/41136949/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,42168117,Hsa-Let-7c-3p Inhibits Retinoblastoma Cell Growth and Metastasis and Induces Pyroptosis by Targeting ARHGAP11A.,2026,10.1111/apm.70213,https://pubmed.ncbi.nlm.nih.gov/42168117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,40104729,Specific effects of hypoxia-immune core gene &lt;i&gt;ARHGAP11A&lt;/i&gt; on lung adenocarcinoma.,2025,10.21037/tcr-24-224,https://pubmed.ncbi.nlm.nih.gov/40104729/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,41307995,ARHGAP11A maintains cortical progenitor identity through RHOA-ROCK signaling during human brain development.,2025,10.1016/j.celrep.2025.116599,https://pubmed.ncbi.nlm.nih.gov/41307995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,40398712,ARHGAP11A is a potential prognostic biomarker and therapeutic target for pancreatic adenocarcinoma.,2025,10.1016/j.biocel.2025.106804,https://pubmed.ncbi.nlm.nih.gov/40398712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,39482272,Machine learning models reveal ARHGAP11A's impact on lymph node metastasis and stemness in NSCLC.,2025,10.1002/biof.2141,https://pubmed.ncbi.nlm.nih.gov/39482272/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,39389782,The hGID&lt;sup&gt;GID4&lt;/sup&gt; E3 ubiquitin ligase complex targets ARHGAP11A to regulate cell migration.,2024,10.26508/lsa.202403046,https://pubmed.ncbi.nlm.nih.gov/39389782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,38783033,Integrated analysis identified the role of three family members of ARHGAP in pancreatic adenocarcinoma.,2024,10.1038/s41598-024-62577-z,https://pubmed.ncbi.nlm.nih.gov/38783033/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,39347089,Rho GTPase activating protein 11A promotes tongue squamous cell carcinoma proliferation and is a transcriptional target of forkhead box M1.,2024,10.1016/j.jds.2024.02.015,https://pubmed.ncbi.nlm.nih.gov/39347089/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,38046902,Protooncogenic Role of ARHGAP11A and ARHGAP11B in Invasive Ductal Carcinoma: Two Promising Breast Cancer Biomarkers.,2023,10.1155/2023/8236853,https://pubmed.ncbi.nlm.nih.gov/38046902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,40642061,Revealing the significance of tissue-resident memory T cells in lung adenocarcinoma through bioinformatic analysis and experimental validation.,2025,10.3389/fimmu.2025.1600863,https://pubmed.ncbi.nlm.nih.gov/40642061/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,39429467,Identification of a central network hub of key prognostic genes based on correlation between transcriptomics and survival in patients with metastatic solid tumors.,2024,10.1177/17588359241289200,https://pubmed.ncbi.nlm.nih.gov/39429467/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,40453146,Characterization of fusion transcripts in AML without recurrent genetic abnormalities unravels new putative fusion genes.,2025,10.1016/j.bneo.2025.100068,https://pubmed.ncbi.nlm.nih.gov/40453146/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,41706758,Human Periodontal Ligament Transcriptomes Under Orthodontic Extrusion and Intrusion: An Exploratory Pilot RNA-Seq Study With an Interactive Public Web Tool.,2026,10.1111/ocr.70103,https://pubmed.ncbi.nlm.nih.gov/41706758/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,36924763,Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development.,2023,10.1016/j.neuron.2023.02.023,https://pubmed.ncbi.nlm.nih.gov/36924763/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,37175461,ARHGAP11A Is a Novel Prognostic and Predictive Biomarker Correlated with Immunosuppressive Microenvironment in Clear Cell Renal Cell Carcinoma.,2023,10.3390/ijms24097755,https://pubmed.ncbi.nlm.nih.gov/37175461/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,34733886,ARHGAP11A Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric Cancer.,2021,10.3389/fmolb.2021.720645,https://pubmed.ncbi.nlm.nih.gov/34733886/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,36098218,Human-specific ARHGAP11B ensures human-like basal progenitor levels in hominid cerebral organoids.,2022,10.15252/embr.202254728,https://pubmed.ncbi.nlm.nih.gov/36098218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,35754342,MicroRNA-30c-2-3p represses malignant progression of gastric adenocarcinoma cells via targeting ARHGAP11A.,2022,10.1080/21655979.2022.2090222,https://pubmed.ncbi.nlm.nih.gov/35754342/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,35495761,Involvement of MiRNA-211-5p and Arhgap11a Interaction During Osteogenic Differentiation of MC3T3-E1 Cells.,2022,10.3389/fsurg.2022.857170,https://pubmed.ncbi.nlm.nih.gov/35495761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,37304542,Prognostic model construction and immune microenvironment analysis of esophageal cancer based on gene expression data and microRNA target genes.,2023,10.21037/tcr-22-2588,https://pubmed.ncbi.nlm.nih.gov/37304542/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,34434651,Identification of a circRNA-miRNA-mRNA regulatory network for exploring novel therapeutic options for glioma.,2021,10.7717/peerj.11894,https://pubmed.ncbi.nlm.nih.gov/34434651/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,33859719,Comprehensive Analysis of the Control of Cancer Stem Cell Characteristics in Endometrial Cancer by Network Analysis.,2021,10.1155/2021/6653295,https://pubmed.ncbi.nlm.nih.gov/33859719/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,27657701,Filling GAPs in our knowledge: ARHGAP11A and RACGAP1 act as oncogenes in basal-like breast cancers.,2018,10.1080/21541248.2016.1220350,https://pubmed.ncbi.nlm.nih.gov/27657701/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,27216196,Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers.,2016,10.1158/0008-5472.can-15-2923,https://pubmed.ncbi.nlm.nih.gov/27216196/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,35117216,Comprehensive analysis of transcriptome data stemness indices identifies key genes for controlling cancer stem cell characteristics in gastric cancer.,2020,10.21037/tcr-20-704,https://pubmed.ncbi.nlm.nih.gov/35117216/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11A,ENSG00000198826,Unsafe,30587197,Integrated analysis of dysregulated long non-coding RNAs/microRNAs/mRNAs in metastasis of lung adenocarcinoma.,2018,10.1186/s12967-018-1732-z,https://pubmed.ncbi.nlm.nih.gov/30587197/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,42129945,Glioblastoma cells utilize evolutionarily adapted cell metabolism to promote their malignant proliferation.,2026,10.1186/s40478-026-02318-7,https://pubmed.ncbi.nlm.nih.gov/42129945/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,39664945,Human-specific gene ARHGAP11B-potentially an additional tool in the treatment of neurodegenerative diseases?,2024,10.3389/fmmed.2024.1465647,https://pubmed.ncbi.nlm.nih.gov/39664945/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,38046902,Protooncogenic Role of ARHGAP11A and ARHGAP11B in Invasive Ductal Carcinoma: Two Promising Breast Cancer Biomarkers.,2023,10.1155/2023/8236853,https://pubmed.ncbi.nlm.nih.gov/38046902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,38658571,Functional synergy of a human-specific and an ape-specific metabolic regulator in human neocortex development.,2024,10.1038/s41467-024-47437-8,https://pubmed.ncbi.nlm.nih.gov/38658571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,36098218,Human-specific ARHGAP11B ensures human-like basal progenitor levels in hominid cerebral organoids.,2022,10.15252/embr.202254728,https://pubmed.ncbi.nlm.nih.gov/36098218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,39998699,Activation of RHO-GTPase gene pattern correlates with adverse clinical outcome and immune microenvironment in clear cell renal cell carcinoma.,2025,10.1007/s10238-025-01593-3,https://pubmed.ncbi.nlm.nih.gov/39998699/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,38189676,Neocortical neurogenesis in development and evolution-Human-specific features.,2024,10.1002/cne.25576,https://pubmed.ncbi.nlm.nih.gov/38189676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,36161459,Filling an ARHGAP in our knowledge of human brain evolution.,2022,10.15252/embr.202256076,https://pubmed.ncbi.nlm.nih.gov/36161459/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,33938018,Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility.,2021,10.15252/embj.2020107093,https://pubmed.ncbi.nlm.nih.gov/33938018/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,39610113,Whole-genome sequencing analysis of Japanese autism spectrum disorder trios.,2025,10.1111/pcn.13767,https://pubmed.ncbi.nlm.nih.gov/39610113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,35358830,Generation of a homozygous ARHGAP11B knockout hiPSC line by CRISPR/Cas9 system.,2022,10.1016/j.scr.2022.102764,https://pubmed.ncbi.nlm.nih.gov/35358830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,34063381,"Human-Specific Genes, Cortical Progenitor Cells, and Microcephaly.",2021,10.3390/cells10051209,https://pubmed.ncbi.nlm.nih.gov/34063381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,32554627,Human-specific &lt;i&gt;ARHGAP11B&lt;/i&gt; increases size and folding of primate neocortex in the fetal marmoset.,2020,10.1126/science.abb2401,https://pubmed.ncbi.nlm.nih.gov/32554627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,30484771,Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex.,2018,10.7554/elife.41241,https://pubmed.ncbi.nlm.nih.gov/30484771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,37270558,"Investigation of enzalutamide, docetaxel, and cabazitaxel resistance in the castration resistant prostate cancer cell line C4 using genome-wide CRISPR/Cas9 screening.",2023,10.1038/s41598-023-35950-7,https://pubmed.ncbi.nlm.nih.gov/37270558/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,31883789,Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis.,2020,10.1016/j.neuron.2019.11.027,https://pubmed.ncbi.nlm.nih.gov/31883789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,27584858,Human adaptation and evolution by segmental duplication.,2016,10.1016/j.gde.2016.08.001,https://pubmed.ncbi.nlm.nih.gov/27584858/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,32135086,What Makes the Human Brain Human?,2020,10.1016/j.neuron.2020.02.007,https://pubmed.ncbi.nlm.nih.gov/32135086/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,36933049,Renal enhanced CT images reveal the tandem mechanism between tumor cells and immunocytes based on bulk/single-cell RNA sequencing.,2023,10.1007/s10142-023-01011-5,https://pubmed.ncbi.nlm.nih.gov/36933049/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,35205235,Functional Innovation through Gene Duplication Followed by Frameshift Mutation.,2022,10.3390/genes13020190,https://pubmed.ncbi.nlm.nih.gov/35205235/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,33510659,CNVs and Chromosomal Aneuploidy in Patients With Early-Onset Schizophrenia and Bipolar Disorder: Genotype-Phenotype Associations.,2020,10.3389/fpsyt.2020.606372,https://pubmed.ncbi.nlm.nih.gov/33510659/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,30886340,De novo single-nucleotide and copy number variation in discordant monozygotic twins reveals disease-related genes.,2019,10.1038/s41431-019-0376-7,https://pubmed.ncbi.nlm.nih.gov/30886340/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,27244233,A pilot study on commonality and specificity of copy number variants in schizophrenia and bipolar disorder.,2016,10.1038/tp.2016.96,https://pubmed.ncbi.nlm.nih.gov/27244233/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP11B,ENSG00000285077,Unsafe,23962720,A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy.,2014,10.1093/hmg/ddt403,https://pubmed.ncbi.nlm.nih.gov/23962720/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,40181839,Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy.,2025,10.1515/med-2025-1146,https://pubmed.ncbi.nlm.nih.gov/40181839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,39199849,Adaptive Evolution and Functional Differentiation of Testis-Expressed Genes in Theria.,2024,10.3390/ani14162316,https://pubmed.ncbi.nlm.nih.gov/39199849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,41072306,Review. The regenerating tail of lizards contains tumor suppressors RNAs and proteins that inhibit cancer cell proliferation.,2026,10.1016/j.tice.2025.103180,https://pubmed.ncbi.nlm.nih.gov/41072306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,38041020,Construction of a prognostic risk score model based on the ARHGAP family to predict the survival of osteosarcoma.,2023,10.1186/s12885-023-11673-w,https://pubmed.ncbi.nlm.nih.gov/38041020/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,39339172,Insights into Asparaginase Allergic Responses: Exploring Pharmacogenetic Influences.,2024,10.3390/pharmaceutics16091134,https://pubmed.ncbi.nlm.nih.gov/39339172/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,35708299,Immunolocalization of tumor suppressors arhgap28 and retinoblastoma in the lizard Podarcis muralis suggests that they contribute to the regulated regeneration of the tail.,2022,10.1002/jmor.21484,https://pubmed.ncbi.nlm.nih.gov/35708299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,32852660,"Gene expression in regenerating and scarring tails of lizard evidences three main key genes (wnt2b, egfl6, and arhgap28) activated during the regulated process of tail regeneration.",2021,10.1007/s00709-020-01545-6,https://pubmed.ncbi.nlm.nih.gov/32852660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,25211221,Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers.,2014,10.1371/journal.pone.0107036,https://pubmed.ncbi.nlm.nih.gov/25211221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,34478856,Review: Regeneration of the tail in lizards appears regulated by a balanced expression of oncogenes and tumor suppressors.,2022,10.1016/j.aanat.2021.151824,https://pubmed.ncbi.nlm.nih.gov/34478856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,26998271,RhoA activity increases due to hypermethylation of ARHGAP28 in a highly liver-metastatic colon cancer cell line.,2016,10.3892/br.2016.582,https://pubmed.ncbi.nlm.nih.gov/26998271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,33041663,"Association between copy-number alteration of +20q, -14q and -18p and cross-sensitivity to tyrosine kinase inhibitors in clear-cell renal cell carcinoma.",2020,10.1186/s12935-020-01585-1,https://pubmed.ncbi.nlm.nih.gov/33041663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,31083655,Array expression meta-analysis of cancer stem cell genes identifies upregulation of PODXL especially in DCC low expression meningiomas.,2019,10.1371/journal.pone.0215452,https://pubmed.ncbi.nlm.nih.gov/31083655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,27980677,"A 18p11.23-p11.31 microduplication in a boy with psychomotor delay, cerebellar vermis hypoplasia, chorioretinal coloboma, deafness and GH deficiency.",2016,10.1186/s13039-016-0298-9,https://pubmed.ncbi.nlm.nih.gov/27980677/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,33802939,Shared Ancestry and Signatures of Recent Selection in Gotland Sheep.,2021,10.3390/genes12030433,https://pubmed.ncbi.nlm.nih.gov/33802939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,32391922,ARHGAP17 inhibits pathological cyclic strain-induced apoptosis in human periodontal ligament fibroblasts via Rac1/Cdc42.,2020,10.1111/1440-1681.13336,https://pubmed.ncbi.nlm.nih.gov/32391922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,30694715,Genome-Wide Association Analysis of Single-Breath DlCO.,2019,10.1165/rcmb.2018-0384oc,https://pubmed.ncbi.nlm.nih.gov/30694715/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,30697902,Genome-wide association study of inhaled corticosteroid response in admixed children with asthma.,2019,10.1111/cea.13354,https://pubmed.ncbi.nlm.nih.gov/30697902/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,19885562,Microarray gene expression profiling in meningiomas: differential expression according to grade or histopathological subtype.,2009,10.3892/ijo_00000457,https://pubmed.ncbi.nlm.nih.gov/19885562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,41229266,Pharmacogenetic markers of PEG-asparaginase toxicity in Brazilian pediatric ALL: insights from a multicenter prospective cohort study.,2025,10.1080/14622416.2025.2572961,https://pubmed.ncbi.nlm.nih.gov/41229266/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,33768542,Class II Human Leukocyte Antigen Variants Associate With Risk of Pegaspargase Hypersensitivity.,2021,10.1002/cpt.2241,https://pubmed.ncbi.nlm.nih.gov/33768542/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGAP28,ENSG00000088756,Unsafe,10718198,Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.,2000,10.1093/dnares/7.1.65,https://pubmed.ncbi.nlm.nih.gov/10718198/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,41779063,Single-cell transcriptomic profiling combined with Mendelian randomization illuminates molecular drivers of bladder cancer.,2026,10.1007/s00438-026-02371-w,https://pubmed.ncbi.nlm.nih.gov/41779063/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,40159883,Establishment and functional studies of a model of cardiomyopathy with cardiomyocyte-specific conditional knockout of Arhgef18.,2025,10.1242/dmm.052172,https://pubmed.ncbi.nlm.nih.gov/40159883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,40920138,SEPTIN9 locally activates the RhoGEF ARHGEF18 to promote early stages of mitochondrial fission.,2025,10.1083/jcb.202406017,https://pubmed.ncbi.nlm.nih.gov/40920138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,39977269,ARHGEF18 is a flow-responsive exchange factor controlling endothelial tight junctions and vascular leakage.,2025,10.1016/j.celrep.2025.115288,https://pubmed.ncbi.nlm.nih.gov/39977269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,40625715,Establishment and identification of cardiomyocyte arhGEF18 gene conditional knockout mice.,2023,10.1002/pdi3.20,https://pubmed.ncbi.nlm.nih.gov/40625715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,41075272,Genetic heterogeneity and homogeneity among orofacial cleft subtypes: genome-wide association studies in the cleft collective.,2025,10.1093/hmg/ddaf131,https://pubmed.ncbi.nlm.nih.gov/41075272/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,41633763,Underlying Paracellular Absorption Mechanism of Egg White-Derived Peptide QIGLF: Insight from 4D-FastDIA Proteomic.,2026,10.1021/acs.jafc.5c17078,https://pubmed.ncbi.nlm.nih.gov/41633763/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,41985271,Genomic correlates of self-reported psychic experiences: An exploratory analysis.,2026,10.1016/j.explore.2026.103416,https://pubmed.ncbi.nlm.nih.gov/41985271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,40362233,Exploring the Role of Circadian Rhythm-Related Genes in the Identification of Sepsis Subtypes and the Construction of Diagnostic Models Based on RNA-seq and scRNA-seq.,2025,10.3390/ijms26093993,https://pubmed.ncbi.nlm.nih.gov/40362233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,39655393,Genomic Effects of Biomechanical Loading in Adolescent Human Growth Plate Cartilage: A Pilot Study.,2026,10.1177/19476035241302954,https://pubmed.ncbi.nlm.nih.gov/39655393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,37720421,"Analysis of Methylome, Transcriptome, and Lipid Metabolites to Understand the Molecular Abnormalities in Polycystic Ovary Syndrome.",2023,10.2147/dmso.s421947,https://pubmed.ncbi.nlm.nih.gov/37720421/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,36912772,Septin-mediated RhoA activation engages the exocyst complex to recruit the cilium transition zone.,2023,10.1083/jcb.201911062,https://pubmed.ncbi.nlm.nih.gov/36912772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,36404918,Downregulation of protein kinase C gamma reduces epithelial property and enhances malignant phenotypes in colorectal cancer cells.,2022,10.1016/j.isci.2022.105501,https://pubmed.ncbi.nlm.nih.gov/36404918/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,29601110,"Expression of novel ""LOCGEF"" isoforms of ARHGEF18 in eosinophils.",2018,10.1002/jlb.2ma1017-418rr,https://pubmed.ncbi.nlm.nih.gov/29601110/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,33842485,ARHGEF18/p114RhoGEF Coordinates PKA/CREB Signaling and Actomyosin Remodeling to Promote Trophoblast Cell-Cell Fusion During Placenta Morphogenesis.,2021,10.3389/fcell.2021.658006,https://pubmed.ncbi.nlm.nih.gov/33842485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,35045818,Revealing potential diagnostic gene biomarkers of septic shock based on machine learning analysis.,2022,10.1186/s12879-022-07056-4,https://pubmed.ncbi.nlm.nih.gov/35045818/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,30405854,Association between a Single Nucleotide Polymorphism in the 3'-UTR of ARHGEF18 and the Risk of Nonidiopathic Pulmonary Arterial Hypertension in Chinese Population.,2018,10.1155/2018/2461845,https://pubmed.ncbi.nlm.nih.gov/30405854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,34336846,High Migration and Invasion Ability of PGCCs and Their Daughter Cells Associated With the Nuclear Localization of S100A10 Modified by SUMOylation.,2021,10.3389/fcell.2021.696871,https://pubmed.ncbi.nlm.nih.gov/34336846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,36860866,An arrayed CRISPR screen of primary B cells reveals the essential elements of the antibody secretion pathway.,2023,10.3389/fimmu.2023.1089243,https://pubmed.ncbi.nlm.nih.gov/36860866/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,31768529,Rho Guanine Nucleotide Exchange Factors Regulate Horizontal Axon Branching of Cortical Upper Layer Neurons.,2020,10.1093/cercor/bhz256,https://pubmed.ncbi.nlm.nih.gov/31768529/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,34354370,An Immune-Related Gene-Based Signature as Prognostic Tool in Ovarian Serous Cystadenocarcinoma.,2021,10.2147/ijgm.s313791,https://pubmed.ncbi.nlm.nih.gov/34354370/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,24808988,Genome-wide SNP analysis of the Systemic Capillary Leak Syndrome (Clarkson disease).,2013,10.4161/rdis.27445,https://pubmed.ncbi.nlm.nih.gov/24808988/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,15558029,"Cytoskeletal modification of Rho guanine nucleotide exchange factor activity: identification of a Rho guanine nucleotide exchange factor as a binding partner for Sept9b, a mammalian septin.",2005,10.1038/sj.onc.1208101,https://pubmed.ncbi.nlm.nih.gov/15558029/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,14512443,"G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production.",2003,10.1161/01.res.0000097607.14733.0c,https://pubmed.ncbi.nlm.nih.gov/14512443/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARHGEF18,ENSG00000104880,Unsafe,11085924,Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor.,2000,10.1042/bj3520319,https://pubmed.ncbi.nlm.nih.gov/11085924/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL17A,ENSG00000185829,Unsafe,42843653,Sex-specific effects of the rs9896243 single nucleotide polymorphism on verbal memory in first episode psychosis: A family-based approach.,2026,10.1016/j.sjpmh.2026.08.001,https://pubmed.ncbi.nlm.nih.gov/42843653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL17A,ENSG00000185829,Unsafe,41570994,The KANSL1-ARL17A fusion gene generates oncogenic chKANSARL and F-circKA RNAs that synergistically drive lung cancer progression via a novel F-circKA/miR-6860/chKANSARL axis.,2026,10.1016/j.jbc.2026.111170,https://pubmed.ncbi.nlm.nih.gov/41570994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL17A,ENSG00000185829,Unsafe,41684331,Cell-Type-Specific Causal Inference Unveils Novel Targets for Parkinson's Disease.,2026,10.1002/mds.70223,https://pubmed.ncbi.nlm.nih.gov/41684331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL17A,ENSG00000185829,Unsafe,41500423,Genotype-driven variations in lncRNA expression underlie predisposition to high-grade serous ovarian cancer.,2026,10.1016/j.jare.2026.01.014,https://pubmed.ncbi.nlm.nih.gov/41500423/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL17A,ENSG00000185829,Unsafe,40411683,Leveraging Alzheimer's Disease Omics to Identify Pleiotropic Genes Contributing to Neurodegeneration in Primary Open-Angle Glaucoma.,2025,10.1007/s12035-025-05074-2,https://pubmed.ncbi.nlm.nih.gov/40411683/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL17A,ENSG00000185829,Unsafe,41394315,Characterisation of the function of a lncRNA containing SINE-VNTR-Alu 67 to regulate the genes at the &lt;i&gt;MAPT&lt;/i&gt; locus.,2025,10.3389/ebm.2025.10805,https://pubmed.ncbi.nlm.nih.gov/41394315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL17A,ENSG00000185829,Unsafe,39394562,Genetic architectures of the human hippocampus and those involved in neuropsychiatric traits.,2024,10.1186/s12916-024-03682-8,https://pubmed.ncbi.nlm.nih.gov/39394562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL17A,ENSG00000185829,Unsafe,39906487,Detection of fusion events by RNA sequencing in FFPE versus freshly frozen colorectal cancer tissue samples.,2024,10.3389/fmolb.2024.1448792,https://pubmed.ncbi.nlm.nih.gov/39906487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL17A,ENSG00000185829,Unsafe,38321229,Late relapse of chronic myeloid leukemia after allogeneic bone marrow transplantation points to KANSARL (KANSL1::ARL17A) alteration: a case report with insights on the molecular landscape.,2024,10.1007/s00277-024-05649-4,https://pubmed.ncbi.nlm.nih.gov/38321229/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL17A,ENSG00000185829,Unsafe,38769620,Association of Gene Expression and Tremor Network Structure.,2024,10.1002/mds.29831,https://pubmed.ncbi.nlm.nih.gov/38769620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL17A,ENSG00000185829,Unsafe,36100668,Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood.,2022,10.1038/s41380-022-01751-z,https://pubmed.ncbi.nlm.nih.gov/36100668/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL17A,ENSG00000185829,Unsafe,28881586,Identification of KANSARL as the first cancer predisposition fusion gene specific to the population of European ancestry origin.,2017,10.18632/oncotarget.16385,https://pubmed.ncbi.nlm.nih.gov/28881586/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL17A,ENSG00000185829,Unsafe,34799557,COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.,2021,10.1038/s41467-021-26888-3,https://pubmed.ncbi.nlm.nih.gov/34799557/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL17A,ENSG00000185829,Unsafe,36183486,Whole genome sequencing identifies candidate genes for familial essential tremor and reveals biological pathways implicated in essential tremor aetiology.,2022,10.1016/j.ebiom.2022.104290,https://pubmed.ncbi.nlm.nih.gov/36183486/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL17A,ENSG00000185829,Unsafe,27115769,"Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci.",2016,10.1007/s00401-016-1576-7,https://pubmed.ncbi.nlm.nih.gov/27115769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL17A,ENSG00000185829,Unsafe,30914738,Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma.,2019,10.1038/s41598-019-41675-3,https://pubmed.ncbi.nlm.nih.gov/30914738/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL17A,ENSG00000185829,Unsafe,32829096,Screening non-MAPT genes of the Chr17q21 H1 haplotype in Parkinson's disease.,2020,10.1016/j.parkreldis.2020.07.022,https://pubmed.ncbi.nlm.nih.gov/32829096/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL17A,ENSG00000185829,Unsafe,25139666,Family based genome-wide copy number scan identifies complex rearrangements at 17q21.31 in dyslexics.,2014,10.1002/ajmg.b.32260,https://pubmed.ncbi.nlm.nih.gov/25139666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,42310154,Establishment and validation of an ADP-ribosylation-related gene signature for prognostic prediction in lung adenocarcinoma.,2026,10.1007/s12672-026-05353-x,https://pubmed.ncbi.nlm.nih.gov/42310154/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,41082129,Machine learning insights into obesity related genes XRCC4 and ARL6 in obstructive sleep apnea.,2025,10.1007/s11325-025-03472-3,https://pubmed.ncbi.nlm.nih.gov/41082129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,39078565,Rod-sparing in a bardet-biedl syndrome patient with mutations in the ARL6 gene.,2024,10.1007/s10633-024-09985-8,https://pubmed.ncbi.nlm.nih.gov/39078565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,40757108,Berg Balance Scale in post-COVID-19 patients: results from a retrospective study.,2025,10.25122/jml-2025-0098,https://pubmed.ncbi.nlm.nih.gov/40757108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,38223458,POMC Neuron BBSome Regulation of Body Weight is Independent of its Ciliary Function.,2024,10.1093/function/zqad070,https://pubmed.ncbi.nlm.nih.gov/38223458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,33517424,"Photoreceptor cilia, in contrast to primary cilia, grant entry to a partially assembled BBSome.",2021,10.1093/hmg/ddaa284,https://pubmed.ncbi.nlm.nih.gov/33517424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,36550847,A Japanese boy with Bardet-Biedl syndrome caused by a novel homozygous variant in the ARL6 gene who was initially diagnosed with retinitis punctata albescens: A case report.,2022,10.1097/md.0000000000032161,https://pubmed.ncbi.nlm.nih.gov/36550847/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,36943875,Unraveling the intricate cargo-BBSome coupling mechanism at the ciliary tip.,2023,10.1073/pnas.2218819120,https://pubmed.ncbi.nlm.nih.gov/36943875/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,36467401,"The complex, dynamic SpliceOme of the small GTPase transcripts altered by technique, sex, genetics, tissue specificity, and RNA base editing.",2022,10.3389/fcell.2022.1033695,https://pubmed.ncbi.nlm.nih.gov/36467401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,40384762,Syndromic forms of inherited retinal dystrophies: a comprehensive molecular diagnosis of consanguineous Pakistani families using capture panel sequencing.,2025,,https://pubmed.ncbi.nlm.nih.gov/40384762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,31953262,Intraflagellar transport protein RABL5/IFT22 recruits the BBSome to the basal body through the GTPase ARL6/BBS3.,2020,10.1073/pnas.1901665117,https://pubmed.ncbi.nlm.nih.gov/31953262/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,33587040,Bardet-Biedl syndrome 3 protein promotes ciliary exit of the signaling protein phospholipase D via the BBSome.,2021,10.7554/elife.59119,https://pubmed.ncbi.nlm.nih.gov/33587040/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,32510327,Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes.,2020,10.7554/elife.55954,https://pubmed.ncbi.nlm.nih.gov/32510327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,39229650,Genetic Contributions to Lower Urinary Tract Dysfunction.,2025,10.1002/ajmg.a.63859,https://pubmed.ncbi.nlm.nih.gov/39229650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,31939736,Structure and activation mechanism of the BBSome membrane protein trafficking complex.,2020,10.7554/elife.53322,https://pubmed.ncbi.nlm.nih.gov/31939736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,29590217,BBS1 is involved in retrograde trafficking of ciliary GPCRs in the context of the BBSome complex.,2018,10.1371/journal.pone.0195005,https://pubmed.ncbi.nlm.nih.gov/29590217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,28502102,Functional analysis by minigene assay of putative splicing variants found in Bardet-Biedl syndrome patients.,2017,10.1111/jcmm.13147,https://pubmed.ncbi.nlm.nih.gov/28502102/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,25443296,The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3.,2014,10.1016/j.devcel.2014.09.004,https://pubmed.ncbi.nlm.nih.gov/25443296/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,29806606,Screening for mutation hotspots in Bardet-Biedl syndrome patients from India.,2018,10.4103/ijmr.ijmr_1822_15,https://pubmed.ncbi.nlm.nih.gov/29806606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,20333246,Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform.,2010,10.1371/journal.pgen.1000884,https://pubmed.ncbi.nlm.nih.gov/20333246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,32522577,MircoRNA-143-3p regulating ARL6 is involved in the cadmium-induced inhibition of osteogenic differentiation in human bone marrow mesenchymal stem cells.,2020,10.1016/j.toxlet.2020.06.001,https://pubmed.ncbi.nlm.nih.gov/32522577/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,36744302,Ubiquitylation of BBSome is required for ciliary assembly and signaling.,2023,10.15252/embr.202255571,https://pubmed.ncbi.nlm.nih.gov/36744302/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,24939912,Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein.,2014,10.1093/hmg/ddu267,https://pubmed.ncbi.nlm.nih.gov/24939912/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,34446551,Chlamydomonas LZTFL1 mediates phototaxis via controlling BBSome recruitment to the basal body and its reassembly at the ciliary tip.,2021,10.1073/pnas.2101590118,https://pubmed.ncbi.nlm.nih.gov/34446551/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARL6,ENSG00000113966,Unsafe,29066540,TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis.,2017,10.1126/scisignal.aam7464,https://pubmed.ncbi.nlm.nih.gov/29066540/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC12,ENSG00000157343,Unsafe,41971121,Homozygous &lt;i&gt;ARMC12&lt;/i&gt; variant causes multiple morphological abnormalities of the sperm flagella.,2026,10.21037/tau-2025-aw-849,https://pubmed.ncbi.nlm.nih.gov/41971121/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC12,ENSG00000157343,Unsafe,41510169,Dual targeting of AMRC12 and &lt;i&gt;Malassezia globosa&lt;/i&gt; disrupts MYC liquid condensates-driven nuclear pore complex biogenesis in neuroblastoma.,2026,10.7150/thno.120935,https://pubmed.ncbi.nlm.nih.gov/41510169/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC12,ENSG00000157343,Unsafe,33536340,ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility.,2021,10.1073/pnas.2018355118,https://pubmed.ncbi.nlm.nih.gov/33536340/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC12,ENSG00000157343,Unsafe,35534203,Biallelic mutations in ARMC12 cause asthenozoospermia and multiple midpiece defects in humans and mice.,2023,10.1136/jmedgenet-2021-108137,https://pubmed.ncbi.nlm.nih.gov/35534203/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC12,ENSG00000157343,Unsafe,34912852,"ARMC Subfamily: Structures, Functions, Evolutions, Interactions, and Diseases.",2021,10.3389/fmolb.2021.791597,https://pubmed.ncbi.nlm.nih.gov/34912852/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC12,ENSG00000157343,Unsafe,37549510,Integrated molecular-network analysis reveals infertility-associated key genes and transcription factors in the non-obstructive azoospermia.,2023,10.1016/j.ejogrb.2023.07.023,https://pubmed.ncbi.nlm.nih.gov/37549510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC12,ENSG00000157343,Unsafe,30026490,Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4.,2018,10.1038/s41467-018-05286-2,https://pubmed.ncbi.nlm.nih.gov/30026490/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC12,ENSG00000157343,Unsafe,37274192,FKBP5 genetic variants are associated with respiratory- and sleep-related parameters in Chinese patients with obstructive sleep apnea.,2023,10.3389/fnins.2023.1170889,https://pubmed.ncbi.nlm.nih.gov/37274192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC12,ENSG00000157343,Unsafe,38017417,Sequenced-based GWAS for linear classification traits in Belgian Blue beef cattle reveals new coding variants in genes regulating body size in mammals.,2023,10.1186/s12711-023-00857-4,https://pubmed.ncbi.nlm.nih.gov/38017417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC12,ENSG00000157343,Unsafe,22035010,Expression levels of 25 genes in liver and testis located in a QTL region for androstenone on SSC7q1.2.,2011,10.1111/j.1365-2052.2011.02195.x,https://pubmed.ncbi.nlm.nih.gov/22035010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,41625278,Knockdown of &lt;i&gt;armc3&lt;/i&gt; Impairs Motile Cilia Function in &lt;i&gt;Schmidtea mediterranea&lt;/i&gt;.,2026,10.17912/micropub.biology.001887,https://pubmed.ncbi.nlm.nih.gov/41625278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,42417609,Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia.,2026,10.7554/elife.110601,https://pubmed.ncbi.nlm.nih.gov/42417609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,39221575,A homozygous ARMC3 splicing variant causes asthenozoospermia and flagellar disorganization in a consanguineous family.,2024,10.1111/cge.14575,https://pubmed.ncbi.nlm.nih.gov/39221575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,42274553,Network Toxicology and Transcriptomic Analyses Reveal Ferroptosis-Related Neurotoxicity of Rotenone as an Environmental Hazardous Compound.,2026,10.3390/cells15110959,https://pubmed.ncbi.nlm.nih.gov/42274553/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,36553564,The Expansion of the Spectrum in Stuttering Disorders to a Novel ARMC Gene Family (ARMC3).,2022,10.3390/genes13122299,https://pubmed.ncbi.nlm.nih.gov/36553564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,40218432,Identification of Candidate Genes and eQTLs Related to Porcine Reproductive Function.,2025,10.3390/ani15071038,https://pubmed.ncbi.nlm.nih.gov/40218432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,37465006,"Erratum to ""Chemical Complementarity of Breast Cancer Resident, T-Cell Receptor CDR3 Domains and the Cancer Antigen, ARMC3, is Associated With Higher Levels of Survival and Granzyme Expression"".",2023,10.1177/11769351231189051,https://pubmed.ncbi.nlm.nih.gov/37465006/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,41913744,Polygenic risk score and phenome-wide association study of the Epstein-Barr virus antibody response.,2026,10.3389/fgene.2026.1786510,https://pubmed.ncbi.nlm.nih.gov/41913744/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,37313373,"Chemical Complementarity of Breast Cancer Resident, T-Cell Receptor CDR3 Domains and the Cancer Antigen, ARMC3, is Associated With Higher Levels of Survival and Granzyme Expression.",2023,10.1177/11769351231177269,https://pubmed.ncbi.nlm.nih.gov/37313373/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,34705610,A conserved Vac8/ARMC3-PtdIns3K-CI cascade regulates autophagy initiation and functions in spermiogenesis by promoting ribophagy.,2021,10.1080/15548627.2021.1988813,https://pubmed.ncbi.nlm.nih.gov/34705610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,32616903,The transcriptional signature associated with human motile cilia.,2020,10.1038/s41598-020-66453-4,https://pubmed.ncbi.nlm.nih.gov/32616903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,34428398,Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility.,2021,10.1016/j.devcel.2021.07.015,https://pubmed.ncbi.nlm.nih.gov/34428398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,39704931,"Homozygous deleterious variants in MYCBPAP induce asthenoteratozoospermia involving abnormal acrosome biogenesis, manchette structure and sperm tail assembly in humans and mice.",2025,10.1007/s11427-024-2757-7,https://pubmed.ncbi.nlm.nih.gov/39704931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,29577858,Expression and Prognostic Relevance of GAGE1 and XAGE1 Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma.,2017,10.2174/1566524018666180322162145,https://pubmed.ncbi.nlm.nih.gov/29577858/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,26923438,A frameshift mutation in ARMC3 is associated with a tail stump sperm defect in Swedish Red (Bos taurus) cattle.,2016,10.1186/s12863-016-0356-7,https://pubmed.ncbi.nlm.nih.gov/26923438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,16915934,"Cloning and expression of ARMC3_v2, a novel splicing variant of the human ARMC3 gene.",2006,,https://pubmed.ncbi.nlm.nih.gov/16915934/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,24467795,Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome.,2014,10.1186/2040-2392-5-4,https://pubmed.ncbi.nlm.nih.gov/24467795/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,16809635,Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression.,2006,10.1165/rcmb.2006-0056oc,https://pubmed.ncbi.nlm.nih.gov/16809635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC3,ENSG00000165309,Unsafe,16397042,"A novel cancer testis antigen that is frequently expressed in pancreatic, lung, and endometrial cancers.",2006,10.1158/1078-0432.ccr-05-1206,https://pubmed.ncbi.nlm.nih.gov/16397042/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,40317322,The interactome of tau phosphorylated at T217 in Alzheimer's disease human brain tissue.,2025,10.1007/s00401-025-02881-8,https://pubmed.ncbi.nlm.nih.gov/40317322/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,37400847,MiR-455-3p inhibits gastric cancer progression by repressing Wnt/β-catenin signaling through binding to ARMC8.,2023,10.1186/s12920-023-01583-y,https://pubmed.ncbi.nlm.nih.gov/37400847/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,38816693,"Transcriptome-based identification and validation of reference genes for corm growth stages, different tissues, and drought stress in Taro (Colocasia esculenta).",2024,10.1186/s12870-024-05199-x,https://pubmed.ncbi.nlm.nih.gov/38816693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,40346622,Knockdown of eIF3a alleviates pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition via TGFβ1/SMAD pathway.,2025,10.1186/s12967-025-06505-3,https://pubmed.ncbi.nlm.nih.gov/40346622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,35396379,METTL3 stabilizes HDAC5 mRNA in an m6A-dependent manner to facilitate malignant proliferation of osteosarcoma cells.,2022,10.1038/s41420-022-00926-5,https://pubmed.ncbi.nlm.nih.gov/35396379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,37707676,GID complex regulates the differentiation of neural stem cells by destabilizing TET2.,2023,10.1007/s11684-023-1007-9,https://pubmed.ncbi.nlm.nih.gov/37707676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,34016486,Downregulation of ARMC8 promotes tumorigenesis through activating Wnt/β-catenin pathway and EMT in cutaneous squamous cell carcinomas.,2021,10.1016/j.jdermsci.2021.05.002,https://pubmed.ncbi.nlm.nih.gov/34016486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,30482882,Armc8 is an evolutionarily conserved armadillo protein involved in cell-cell adhesion complexes through multiple molecular interactions.,2019,10.1042/bsr20180604,https://pubmed.ncbi.nlm.nih.gov/30482882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,36680668,Discovery of differentially expressed novel miRNAs in breast normal cells and their putative targets.,2023,10.1007/s11010-023-04665-8,https://pubmed.ncbi.nlm.nih.gov/36680668/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,35516861,The micro RNA hsa-miR-377-3p inhibits tumor growth in malignant melanoma.,2019,10.1039/c9ra02816a,https://pubmed.ncbi.nlm.nih.gov/35516861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,28081738,Silencing of Armadillo Repeat-Containing Protein 8 (ARMc8) Inhibits TGF-β-Induced EMT in Bladder Carcinoma UMUC3 Cells.,2017,10.3727/096504016x14719078133609,https://pubmed.ncbi.nlm.nih.gov/28081738/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,35780638,The expression and prognostic significance of PIK3CB in lung adenocarcinoma.,2022,10.1016/j.anndiagpath.2022.152001,https://pubmed.ncbi.nlm.nih.gov/35780638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,32547335,MiR-664 Protects Against UVB Radiation-Induced HaCaT Cell Damage via Downregulating ARMC8.,2020,10.1177/1559325820929234,https://pubmed.ncbi.nlm.nih.gov/32547335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,31885576,The CTLH Complex in Cancer Cell Plasticity.,2019,10.1155/2019/4216750,https://pubmed.ncbi.nlm.nih.gov/31885576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,27712595,Armadillo Repeat-Containing Protein 8 (ARMC8) Silencing Inhibits Proliferation and Invasion in Osteosarcoma Cells.,2016,10.3727/096504016x14685034103392,https://pubmed.ncbi.nlm.nih.gov/27712595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,26081621,ARMc8 indicates aggressive colon cancers and promotes invasiveness and migration of colon cancer cells.,2015,10.1007/s13277-015-3664-z,https://pubmed.ncbi.nlm.nih.gov/26081621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,26944057,Armc8 regulates the invasive ability of hepatocellular carcinoma through E-cadherin/catenin complex.,2016,10.1007/s13277-016-5006-1,https://pubmed.ncbi.nlm.nih.gov/26944057/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,26232863,A novel biomarker ARMc8 promotes the malignant progression of ovarian cancer.,2015,10.1016/j.humpath.2015.06.004,https://pubmed.ncbi.nlm.nih.gov/26232863/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,30036398,Investigation of epigenetic regulatory networks associated with autism spectrum disorder (ASD) by integrated global LINE-1 methylation and gene expression profiling analyses.,2018,10.1371/journal.pone.0201071,https://pubmed.ncbi.nlm.nih.gov/30036398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,25119601,Armc8 expression was elevated during atypia-to-carcinoma progression and associated with cancer development of breast carcinoma.,2014,10.1007/s13277-014-2473-0,https://pubmed.ncbi.nlm.nih.gov/25119601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,31285494,The mammalian CTLH complex is an E3 ubiquitin ligase that targets its subunit muskelin for degradation.,2019,10.1038/s41598-019-46279-5,https://pubmed.ncbi.nlm.nih.gov/31285494/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,26568774,The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects.,2015,10.1186/s13148-015-0154-5,https://pubmed.ncbi.nlm.nih.gov/26568774/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,23997114,"Genome-wide RNAi high-throughput screen identifies proteins necessary for the AHR-dependent induction of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin.",2013,10.1093/toxsci/kft191,https://pubmed.ncbi.nlm.nih.gov/23997114/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARMC8,ENSG00000114098,Unsafe,25329471,The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels.,2014,10.1371/journal.pone.0109290,https://pubmed.ncbi.nlm.nih.gov/25329471/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARRDC5,ENSG00000205784,Unsafe,42634475,Spatiotemporal Expression of ARRDC5 in Mammalian Spermatogenesis.,2026,10.1111/andr.70356,https://pubmed.ncbi.nlm.nih.gov/42634475/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARRDC5,ENSG00000205784,Unsafe,42750330,[Production and application of rabbit polyclonal antibody against ARRDC5].,2026,,https://pubmed.ncbi.nlm.nih.gov/42750330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARRDC5,ENSG00000205784,Unsafe,41420860,Biogenesis and migration of the sperm cytoplasmic droplet require ARRDC5 and TEX38.,2026,10.1016/j.celrep.2025.116731,https://pubmed.ncbi.nlm.nih.gov/41420860/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARRDC5,ENSG00000205784,Unsafe,40783453,Disruption of TEX38 impairs sperm morphogenesis and the migration of sperm into the oviduct.,2025,10.1038/s42003-025-08644-1,https://pubmed.ncbi.nlm.nih.gov/40783453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARRDC5,ENSG00000205784,Unsafe,41147775,Impaired embryogenesis following intracytoplasmic sperm injection with an Arrdc5-/- mouse model of oligoasthenoteratospermia†.,2026,10.1093/biolre/ioaf240,https://pubmed.ncbi.nlm.nih.gov/41147775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARRDC5,ENSG00000205784,Unsafe,37069147,ARRDC5 expression is conserved in mammalian testes and required for normal sperm morphogenesis.,2023,10.1038/s41467-023-37735-y,https://pubmed.ncbi.nlm.nih.gov/37069147/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARRDC5,ENSG00000205784,Unsafe,40030029,TEX38 localizes ZDHHC19 to the plasma membrane and regulates sperm head morphogenesis in mice.,2025,10.1073/pnas.2417943122,https://pubmed.ncbi.nlm.nih.gov/40030029/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARRDC5,ENSG00000205784,Unsafe,37997706,ARRDC5 deficiency impairs spermatogenesis by affecting SUN5 and NDC1.,2023,10.1242/dev.201959,https://pubmed.ncbi.nlm.nih.gov/37997706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARRDC5,ENSG00000205784,Unsafe,38270169,Comparative interactome analysis of α-arrestin families in human and Drosophila.,2024,10.7554/elife.88328,https://pubmed.ncbi.nlm.nih.gov/38270169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARRDC5,ENSG00000205784,Unsafe,35433762,Identification of an Immune Classification and Prognostic Genes for Lung Adenocarcinoma Based on Immune Cell Signatures.,2022,10.3389/fmed.2022.855387,https://pubmed.ncbi.nlm.nih.gov/35433762/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARRDC5,ENSG00000205784,Unsafe,32671597,A pooled genome-wide association study identifies pancreatic cancer susceptibility loci on chromosome 19p12 and 19p13.3 in the full-Jewish population.,2021,10.1007/s00439-020-02205-8,https://pubmed.ncbi.nlm.nih.gov/32671597/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ARRDC5,ENSG00000205784,Unsafe,30397551,Ensemble learning for detecting gene-gene interactions in colorectal cancer.,2018,10.7717/peerj.5854,https://pubmed.ncbi.nlm.nih.gov/30397551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,38471398,High lymphocyte signature genes expression in parathyroid endocrine cells and its downregulation linked to tumorigenesis.,2024,10.1016/j.ebiom.2024.105053,https://pubmed.ncbi.nlm.nih.gov/38471398/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,36913068,LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation.,2023,10.1007/s13402-023-00783-z,https://pubmed.ncbi.nlm.nih.gov/36913068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,37208735,Isoliensinine from Cissampelos pariera rhizomes exhibits potential gametocytocidal and anti-malarial activities against Plasmodium falciparum clinical isolates.,2023,10.1186/s12936-023-04590-7,https://pubmed.ncbi.nlm.nih.gov/37208735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,35770973,Adaptor linked K63 di-ubiquitin activates Nedd4/Rsp5 E3 ligase.,2022,10.7554/elife.77424,https://pubmed.ncbi.nlm.nih.gov/35770973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,35491857,Beneficial interaction between Ficus platyphylla and artesunate on cytokines TNF-α and IL-10 and oxidative stress in Plasmodium berghei-infected mice.,2022,10.17420/ap6801.415,https://pubmed.ncbi.nlm.nih.gov/35491857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,38390300,Enhancing stress resilience in rice (Oryza sativa L.) through profiling early-stage morpho-physiological and molecular responses to multiple abiotic stress tolerance.,2024,10.3389/fpls.2024.1342441,https://pubmed.ncbi.nlm.nih.gov/38390300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,30627052,Identification of a 6-gene signature predicting prognosis for colorectal cancer.,2019,10.1186/s12935-018-0724-7,https://pubmed.ncbi.nlm.nih.gov/30627052/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,31519807,The lncRNA hsrω regulates arginine dimethylation of human FUS to cause its proteasomal degradation in Drosophila.,2019,10.1242/jcs.236836,https://pubmed.ncbi.nlm.nih.gov/31519807/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,20074554,Identification of yeast Art5 as a multicopy suppressor for the mitochondrial translocator maintenance protein Tam41.,2010,10.1016/j.bbrc.2010.01.024,https://pubmed.ncbi.nlm.nih.gov/20074554/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,11587854,"Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5.",2001,10.1016/s0378-1119(01)00608-4,https://pubmed.ncbi.nlm.nih.gov/11587854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,29043790,"Emissive Synthetic Cofactors: An Isomorphic, Isofunctional, and Responsive NAD+ Analogue.",2017,10.1021/jacs.7b05852,https://pubmed.ncbi.nlm.nih.gov/29043790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,25781026,Inositol depletion restores vesicle transport in yeast phospholipid flippase mutants.,2015,10.1371/journal.pone.0120108,https://pubmed.ncbi.nlm.nih.gov/25781026/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,23623749,Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria.,2013,10.1016/j.cmet.2013.03.018,https://pubmed.ncbi.nlm.nih.gov/23623749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,10448534,"Characterization of glycosylphosphatidylinositiol-anchored, secreted, and intracellular vertebrate mono-ADP-ribosyltransferases.",1999,10.1146/annurev.nutr.19.1.485,https://pubmed.ncbi.nlm.nih.gov/10448534/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,19912579,Arrestin-mediated endocytosis of yeast plasma membrane transporters.,2009,10.1111/j.1600-0854.2009.00990.x,https://pubmed.ncbi.nlm.nih.gov/19912579/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,16627471,ADP-ribosyltransferase-specific modification of human neutrophil peptide-1.,2006,10.1074/jbc.m603042200,https://pubmed.ncbi.nlm.nih.gov/16627471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,15078170,Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling.,2004,10.2174/0929867043455611,https://pubmed.ncbi.nlm.nih.gov/15078170/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,17707376,Expression and selective up-regulation of toxin-related mono ADP-ribosyltransferases by pathogen-associated molecular patterns in alveolar epithelial cells.,2007,10.1016/j.febslet.2007.07.061,https://pubmed.ncbi.nlm.nih.gov/17707376/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,32226077,Assessing the risks of introduced chickens and their pathogens to native birds in the Galápagos Archipelago.,2005,10.1016/j.biocon.2005.06.025,https://pubmed.ncbi.nlm.nih.gov/32226077/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ART5,ENSG00000167311,Unsafe,10331646,Characterization of NAD:arginine ADP-ribosyltransferases.,1999,10.1023/a:1006924514074,https://pubmed.ncbi.nlm.nih.gov/10331646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB14,ENSG00000239388,Unsafe,40417864,"Integrating Multiomics to Reveal and Validate Key Proteins, Metabolites, and Pathways of ASB14 Affecting Mitochondrial Function in Cardiomyocytes AC16.",2025,10.1096/fj.202500366r,https://pubmed.ncbi.nlm.nih.gov/40417864/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB14,ENSG00000239388,Unsafe,42205681,Evolocumab Alters Transcriptomic Signatures and Identifies Inflammatory Biomarkers in Brain-Heart Syndrome with Coronary Heart Disease History.,2026,10.2147/ijgm.s603395,https://pubmed.ncbi.nlm.nih.gov/42205681/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB14,ENSG00000239388,Unsafe,39409914,Genomic and Socioeconomic Determinants of Racial Disparities in Breast Cancer Survival: Insights from the All of Us Program.,2024,10.3390/cancers16193294,https://pubmed.ncbi.nlm.nih.gov/39409914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB14,ENSG00000239388,Unsafe,30370655,Potential biomarkers for heart failure.,2019,10.1002/jcp.27632,https://pubmed.ncbi.nlm.nih.gov/30370655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB14,ENSG00000239388,Unsafe,32168507,Analysis of gene variants in the GASH/Sal model of epilepsy.,2020,10.1371/journal.pone.0229953,https://pubmed.ncbi.nlm.nih.gov/32168507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB14,ENSG00000239388,Unsafe,27796761,In-Depth Proteomic Analysis of the Porcine Retina by Use of a four Step Differential Extraction Bottom up LC MS Platform.,2017,10.1007/s12035-016-0172-0,https://pubmed.ncbi.nlm.nih.gov/27796761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB14,ENSG00000239388,Unsafe,27031336,Isolation of a Genomic Region Affecting Most Components of Metabolic Syndrome in a Chromosome-16 Congenic Rat Model.,2016,10.1371/journal.pone.0152708,https://pubmed.ncbi.nlm.nih.gov/27031336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,42665045,ASB3 limits adipocyte thermogenesis and energy expenditure through p62 ubiquitination.,2026,10.1016/j.metabol.2026.156756,https://pubmed.ncbi.nlm.nih.gov/42665045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,40755808,ASB3 ablation has no detectable effects on spermatogenesis and fertility in male mice.,2025,10.7717/peerj.19738,https://pubmed.ncbi.nlm.nih.gov/40755808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,40776473,Hepatocytic ankyrin repeat and SOCS box protein 3 deficiency alleviates metabolic dysfunction-associated steatotic liver disease by decreasing ubiquitin-mediated carnitine palmitoyl transferase 1A.,2025,10.3350/cmh.2024.1041,https://pubmed.ncbi.nlm.nih.gov/40776473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,41493825,Nicotinamide riboside enhances liver regeneration via the MCART1/ASB3 axis in obesity-compromised rats.,2026,10.1097/hc9.0000000000000866,https://pubmed.ncbi.nlm.nih.gov/41493825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,40984670,"ASB3 degrades the gateway to β-oxidation: Editorial on ""Hepatocytic ankyrin repeat and SOCS box protein 3 deficiency alleviates metabolic dysfunction-associated steatotic liver disease by decreasing ubiquitin-mediated carnitine palmitoyl transferase 1A"".",2026,10.3350/cmh.2025.1021,https://pubmed.ncbi.nlm.nih.gov/40984670/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,39162488,ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota.,2024,10.1128/mbio.02043-24,https://pubmed.ncbi.nlm.nih.gov/39162488/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,40947606,"Targeting the ASB3-CPT1A axis-a new player in combating metabolic dysfunction-associated steatotic liver disease: Editorial on ""Hepatocytic ankyrin repeat and SOCS box protein 3 deficiency alleviates metabolic dysfunction-associated steatotic liver disease by decreasing ubiquitin-mediated carnitine palmitoyltransferase 1A"".",2026,10.3350/cmh.2025.1013,https://pubmed.ncbi.nlm.nih.gov/40947606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,39266719,The E3 ligase ASB3 downregulates antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation.,2024,10.1038/s41418-024-01376-5,https://pubmed.ncbi.nlm.nih.gov/39266719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,40033405,Genetic overlap between schizophrenia and constipation: insights from a genome-wide association study in a European population.,2025,10.1186/s12991-025-00551-3,https://pubmed.ncbi.nlm.nih.gov/40033405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,37925796,Comprehensive analysis of ASB3 as a prognostic biomarker in hepatocellular carcinoma.,2024,10.1016/j.tranon.2023.101816,https://pubmed.ncbi.nlm.nih.gov/37925796/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,36618381,Pan-cancer analysis of ASB3 and the potential clinical implications for immune microenvironment of glioblastoma multiforme.,2022,10.3389/fimmu.2022.842524,https://pubmed.ncbi.nlm.nih.gov/36618381/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,41992370,Early blood DNA methylation patterns associated with glycemic progression in a prospective Indian cohort.,2026,10.1186/s13148-026-02064-6,https://pubmed.ncbi.nlm.nih.gov/41992370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,38334450,ASB3 promotes hepatocellular carcinoma progression by mediating DR5 ubiquitination in TRAIL resistance.,2024,10.1096/fj.202301755r,https://pubmed.ncbi.nlm.nih.gov/38334450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,39886999,A replication study of novel fetal hemoglobin-associated genetic variants in sickle cell disease-only cohorts.,2025,10.1093/hmg/ddaf015,https://pubmed.ncbi.nlm.nih.gov/39886999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,39399486,"Gut microbiota and interstitial cystitis: exploring the gut-bladder axis through mendelian randomization, biological annotation and bulk RNA sequencing.",2024,10.3389/fimmu.2024.1395580,https://pubmed.ncbi.nlm.nih.gov/39399486/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,36119500,Expression pattern of non-coding RNAs in non-functioning pituitary adenoma.,2022,10.3389/fonc.2022.978016,https://pubmed.ncbi.nlm.nih.gov/36119500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,35492076,Bioinformatics Analysis of Stem Cell circ-ASB3 Signaling Pathway and Its Affection on Glioma Biological Characteristics.,2022,10.3389/fninf.2022.859937,https://pubmed.ncbi.nlm.nih.gov/35492076/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,36835202,Co-Expression Analysis of Airway Epithelial Transcriptome in Asthma Patients with Eosinophilic vs. Non-Eosinophilic Airway Infiltration.,2023,10.3390/ijms24043789,https://pubmed.ncbi.nlm.nih.gov/36835202/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,28088228,The loss-of-function mutations and down-regulated expression of ASB3 gene promote the growth and metastasis of colorectal cancer cells.,2017,10.1186/s40880-017-0180-0,https://pubmed.ncbi.nlm.nih.gov/28088228/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,31016535,ASB3 knockdown promotes mitochondrial apoptosis via activating the interdependent cleavage of Beclin1 and caspase-8 in hepatocellular carcinoma.,2019,10.1007/s11427-018-9505-0,https://pubmed.ncbi.nlm.nih.gov/31016535/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,34958416,Pharmacogenetics of Bronchodilator Response: Future Directions.,2021,10.1007/s11882-021-01023-w,https://pubmed.ncbi.nlm.nih.gov/34958416/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,32256100,Pharmacogenetics of Pediatric Asthma: Current Perspectives.,2020,10.2147/pgpm.s201276,https://pubmed.ncbi.nlm.nih.gov/32256100/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,25562107,Genome-wide association study of short-acting β2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3.,2015,10.1164/rccm.201408-1426oc,https://pubmed.ncbi.nlm.nih.gov/25562107/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,30585438,Longitudinal analysis of bronchodilator response in asthmatics and effect modification of age-related trends by genotype.,2019,10.1002/ppul.24219,https://pubmed.ncbi.nlm.nih.gov/30585438/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,35438046,ncRNAs and polyphenols: new therapeutic strategies for hypertension.,2022,10.1080/15476286.2022.2066335,https://pubmed.ncbi.nlm.nih.gov/35438046/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,26818947,Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.,2016,10.1038/ncomms10531,https://pubmed.ncbi.nlm.nih.gov/26818947/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,15899873,Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II.,2005,10.1128/mcb.25.11.4716-4726.2005,https://pubmed.ncbi.nlm.nih.gov/15899873/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB3,ENSG00000115239,Unsafe,20846475,Specific inhibition of protein kinase Cbeta expression by antisense RNA affects the activation of Jurkat T lymphoma cells.,2010,,https://pubmed.ncbi.nlm.nih.gov/20846475/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,41730923,A testis-specific E3 ubiquitin ligase complex governs spermiogenesis and male fertility.,2026,10.1038/s41467-026-70025-x,https://pubmed.ncbi.nlm.nih.gov/41730923/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,41915740,ASB9 promotes ubiquitin-mediated degradation of TNP2 to facilitate histone-to-protamine transition in humans and mice.,2026,10.1073/pnas.2522270123,https://pubmed.ncbi.nlm.nih.gov/41915740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,42491188,WSB1 is dispensable for mouse spermatogenesis and male fertility.,2026,10.62347/qhcl8624,https://pubmed.ncbi.nlm.nih.gov/42491188/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,41260500,The Mechanism of Histone Ubiquitylation by the ASB9-CUL5 Ubiquitin Ligase.,2026,10.1016/j.mcpro.2025.101471,https://pubmed.ncbi.nlm.nih.gov/41260500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,41154747,The Negative Role of Ankyrin-Repeat and SOCS-Box Protein 9 in PAR1 Expression and the MAPK Signaling Pathway in Bovine Granulosa Cells.,2025,10.3390/biology14101344,https://pubmed.ncbi.nlm.nih.gov/41154747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,36683111,Ubiquitin protein E3 ligase ASB9 suppresses proliferation and promotes apoptosis in human spermatogonial stem cell line by inducing HIF1AN degradation.,2023,10.1186/s40659-023-00413-w,https://pubmed.ncbi.nlm.nih.gov/36683111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,41324311,Plasma Protein Mediation of the Association Between Blood Pressure and Retinal Vascular Occlusion.,2025,10.1167/tvst.14.12.2,https://pubmed.ncbi.nlm.nih.gov/41324311/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,40371706,scRNA-seq and scATAC-seq reveal that Sertoli cell mediates spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia.,2025,10.7554/elife.97958,https://pubmed.ncbi.nlm.nih.gov/40371706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,41003765,Big data analysis reveals miR-874 as a suppressor and therapeutic target in the progression from endometriosis to ovarian cancer.,2025,10.1007/s12672-025-03587-9,https://pubmed.ncbi.nlm.nih.gov/41003765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,36833266,"Molecular Characterization, Expression Profile, and A 21-bp Indel within the ASB9 Gene and Its Associations with Chicken Production Traits.",2023,10.3390/genes14020339,https://pubmed.ncbi.nlm.nih.gov/36833266/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,37280645,CLOCK inhibits the proliferation of porcine ovarian granulosa cells by targeting ASB9.,2023,10.1186/s40104-023-00884-7,https://pubmed.ncbi.nlm.nih.gov/37280645/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,39706197,Chromosome X-wide common variant association study in autism spectrum disorder.,2025,10.1016/j.ajhg.2024.11.008,https://pubmed.ncbi.nlm.nih.gov/39706197/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,40117286,Genomic analysis of bovine respiratory disease resistance in preweaned dairy calves diagnosed by a combination of clinical signs and thoracic ultrasonography.,2025,10.1371/journal.pone.0318520,https://pubmed.ncbi.nlm.nih.gov/40117286/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,34476862,Ankyrin-repeat and SOCS box-containing protein 9 (ASB9) regulates ovarian granulosa cells function and MAPK signaling.,2021,10.1002/mrd.23532,https://pubmed.ncbi.nlm.nih.gov/34476862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,30811458,Gonadotropin regulation of ankyrin-repeat and SOCS-box protein 9 (ASB9) in ovarian follicles and identification of binding partners.,2019,10.1371/journal.pone.0212571,https://pubmed.ncbi.nlm.nih.gov/30811458/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,34190177,Identification of key miRNAs and their targets in peripheral blood mononuclear cells of IgA nephropathy using bioinformatics analysis.,2021,10.1097/md.0000000000026495,https://pubmed.ncbi.nlm.nih.gov/34190177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,33268465,The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases.,2021,10.1074/mcp.ra120.002414,https://pubmed.ncbi.nlm.nih.gov/33268465/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,32513959,Structure and dynamics of the ASB9 CUL-RING E3 Ligase.,2020,10.1038/s41467-020-16499-9,https://pubmed.ncbi.nlm.nih.gov/32513959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,32547947,Identification of Potential Key Genes for Pathogenesis and Prognosis in Prostate Cancer by Integrated Analysis of Gene Expression Profiles and the Cancer Genome Atlas.,2020,10.3389/fonc.2020.00809,https://pubmed.ncbi.nlm.nih.gov/32547947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,27396830,"Model of the Ankyrin and SOCS Box Protein, ASB9, E3 Ligase Reveals a Mechanism for Dynamic Ubiquitin Transfer.",2016,10.1016/j.str.2016.05.016,https://pubmed.ncbi.nlm.nih.gov/27396830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,25654263,"How the ankyrin and SOCS box protein, ASB9, binds to creatine kinase.",2015,10.1021/bi501420n,https://pubmed.ncbi.nlm.nih.gov/25654263/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,29132311,Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI.,2017,10.1186/s12864-017-4257-6,https://pubmed.ncbi.nlm.nih.gov/29132311/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASB9,ENSG00000102048,Unsafe,20302626,ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function.,2010,10.1186/1741-7007-8-23,https://pubmed.ncbi.nlm.nih.gov/20302626/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,42193960,A Feedback Loop Driven by H3K18la and ASF1B via the LINC02732-miR-1291 Axis Promotes Hepatocellular Carcinoma Proliferation.,2026,10.3390/cells15100952,https://pubmed.ncbi.nlm.nih.gov/42193960/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,42100853,ASF1B promotes erythropoiesis by regulating the establishment and enrichment of H3.3 nucleosomes.,2026,10.1093/nar/gkag447,https://pubmed.ncbi.nlm.nih.gov/42100853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,42114389,Ablation of ASF1B mitigates the proliferation of A549 cells and enhances anti-PD-L1 therapy by regulating ferroptosis.,2026,10.1016/j.tice.2026.103584,https://pubmed.ncbi.nlm.nih.gov/42114389/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,40944429,Bioinformatics Analysis and Experimental Validation of ASF1B in Breast Tumors.,2025,10.1002/cam4.71073,https://pubmed.ncbi.nlm.nih.gov/40944429/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,41535416,ASF1B promotes gastric cancer liver metastasis through inhibiting ZDHHC9/PCBP1/ SLC7A11 signaling axis mediated ferroptosis.,2026,10.1038/s41698-026-01272-w,https://pubmed.ncbi.nlm.nih.gov/41535416/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,42557476,Lactobacillus plantarum-derived indole-3-lactic acid inhibits prostate cancer progression through ASF1B/ENO1 axis and remodels the tumor microenvironment to enhance anti-PD-1 therapy.,2026,10.1186/s43556-026-00540-2,https://pubmed.ncbi.nlm.nih.gov/42557476/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,41585149,APOBEC3B/ASF1B-TGF-β signaling axis promotes epithelial-mesenchymal transition in HPV-positive oropharyngeal cancer.,2026,10.1016/j.jds.2025.10.039,https://pubmed.ncbi.nlm.nih.gov/41585149/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,40041497,ASF1B promotes gastric cancer progression by modulating H2AC20 and activating PI3K/AKT and ERK1/2 pathways.,2025,10.3389/fphar.2025.1533257,https://pubmed.ncbi.nlm.nih.gov/40041497/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,39702777,Histone variant H3.5 in testicular cell differentiation and its interactions with histone chaperones.,2024,10.1038/s41598-024-83206-9,https://pubmed.ncbi.nlm.nih.gov/39702777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,40770782,Identification of hub genes predicting sensitivity to neoadjuvant chemoradiation in locally advanced rectal cancer.,2025,10.2478/raon-2025-0005,https://pubmed.ncbi.nlm.nih.gov/40770782/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,38164276,Carcinogenic Role and Clinical Significance of Histone H3-H4 Chaperone Anti-silencing Function 1 B (ASF1B) in Lung Adenocarcinoma.,2024,10.7150/jca.88777,https://pubmed.ncbi.nlm.nih.gov/38164276/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,36947060,The interaction between ASF1B and TLK1 promotes the malignant progression of low-grade glioma.,2023,10.1080/07853890.2023.2169751,https://pubmed.ncbi.nlm.nih.gov/36947060/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,39018712,ASF1B is an essential prognostic indicator linked to the growth and resistance characteristics of bladder cancer.,2024,10.1016/j.tice.2024.102477,https://pubmed.ncbi.nlm.nih.gov/39018712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,40908175,Dysregulation of chromatin remodeling genes predicts clinical outcomes in acute myeloid leukemia.,2025,10.1016/j.jfma.2025.08.045,https://pubmed.ncbi.nlm.nih.gov/40908175/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,38971916,Investigation on the molecular mechanism of SPA interference with osteogenic differentiation of bone marrow mesenchymal stem cells.,2024,10.1038/s41598-024-66502-2,https://pubmed.ncbi.nlm.nih.gov/38971916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,38498025,The TLK-ASF1 histone chaperone pathway plays a critical role in IL-1β-mediated AML progression.,2024,10.1182/blood.2023022079,https://pubmed.ncbi.nlm.nih.gov/38498025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,40996677,Identification of immunosuppressive CD4&lt;sup&gt;+&lt;/sup&gt; T-cell subtype and construction of prognostic model for hepatocellular carcinoma.,2025,10.1007/s12672-025-03556-2,https://pubmed.ncbi.nlm.nih.gov/40996677/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,38050219,ASF1B acted as a prognostic biomarker for stomach adenocarcinoma.,2023,10.1097/md.0000000000035408,https://pubmed.ncbi.nlm.nih.gov/38050219/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,37153049,"Knockdown of ASF1B inhibits cell proliferation, migration, invasion and cisplatin resistance in gastric cancer through the Myc pathway.",2023,10.3892/ol.2023.13828,https://pubmed.ncbi.nlm.nih.gov/37153049/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,35875094,Increased ASF1B Expression Correlates With Poor Prognosis in Patients With Gliomas.,2022,10.3389/fonc.2022.912101,https://pubmed.ncbi.nlm.nih.gov/35875094/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,37937108,Identification of ASF1B as a prognostic marker for liver cancer by meta-analysis and its immune value revealed by a comprehensive pan-cancer analysis of 33 human cancers.,2023,10.5114/pg.2023.124423,https://pubmed.ncbi.nlm.nih.gov/37937108/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,35360875,ASF1B is a Promising Prognostic Biomarker and Correlates With Immunotherapy Efficacy in Hepatocellular Carcinoma.,2022,10.3389/fgene.2022.842351,https://pubmed.ncbi.nlm.nih.gov/35360875/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,41606085,Defining the heterogeneous molecular landscape of lung cancer cell responses to epigenetic inhibition.,2026,10.1038/s42003-025-09455-0,https://pubmed.ncbi.nlm.nih.gov/41606085/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,34472711,Comprehensive analysis of pan-cancer reveals potential of ASF1B as a prognostic and immunological biomarker.,2021,10.1002/cam4.4203,https://pubmed.ncbi.nlm.nih.gov/34472711/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,35174076,"ASF1B: A Possible Prognostic Marker, Therapeutic Target, and Predictor of Immunotherapy in Male Thyroid Carcinoma.",2022,10.3389/fonc.2022.678025,https://pubmed.ncbi.nlm.nih.gov/35174076/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,34336642,Construction of Novel lncRNA-miRNA-mRNA Network Associated With Recurrence and Identification of Immune-Related Potential Regulatory Axis in Hepatocellular Carcinoma.,2021,10.3389/fonc.2021.626663,https://pubmed.ncbi.nlm.nih.gov/34336642/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,35087760,ASF1B Serves as a Potential Therapeutic Target by Influencing Cell Cycle and Proliferation in Hepatocellular Carcinoma.,2021,10.3389/fonc.2021.801506,https://pubmed.ncbi.nlm.nih.gov/35087760/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASF1B,ENSG00000105011,Unsafe,12842904,Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis.,2003,10.1074/jbc.m303549200,https://pubmed.ncbi.nlm.nih.gov/12842904/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,42432741,Allogeneic mesenchymal stromal cells ameliorate lupus nephritis by regulating lipid metabolism via ASGR1.,2026,10.1186/s13287-026-05167-2,https://pubmed.ncbi.nlm.nih.gov/42432741/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,42298709,The asialoglycoprotein receptor 1 (ASGR1): emerging new roles in health and disease.,2026,10.1186/s40364-026-00954-8,https://pubmed.ncbi.nlm.nih.gov/42298709/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,42773283,Proteome-wide genetic analyses identify ASGR1 as a potential biomarker linking smoking with ischemic heart disease.,2026,10.1038/s44161-026-00871-x,https://pubmed.ncbi.nlm.nih.gov/42773283/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,42619505,ASGR1 Deficiency Promotes Liver Fibrosis by Enhancing Pro-Inflammatory Arachidonic Acid Metabolism and ALP Secretion.,2026,10.1002/iid3.70496,https://pubmed.ncbi.nlm.nih.gov/42619505/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,42617834,ASGR1 exacerbates MASLD by inducing hepatocyte senescence via lysosomal dysfunction and HIF-1α stabilization.,2026,10.1016/j.metabol.2026.156747,https://pubmed.ncbi.nlm.nih.gov/42617834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,42198846,In vivo base editing of Asgr1 reduces blood lipids in mice.,2026,10.1016/j.ymthe.2026.05.020,https://pubmed.ncbi.nlm.nih.gov/42198846/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,42264088,Asialoglycoprotein receptor subunit Asgr1a loss results in attenuated cholesterol absorption in zebrafish fed a western diet.,2026,10.1016/j.jbc.2026.113239,https://pubmed.ncbi.nlm.nih.gov/42264088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,42048115,Elevated ASGR1 as a Potential Diagnostic Biomarker for Coronary Artery Disease and Predictor of Adverse Outcomes in Hypertensive Patients.,2026,10.1096/fj.202504652rr,https://pubmed.ncbi.nlm.nih.gov/42048115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,42470100,Precise hepatic base editing of ASGR1 enables robust and durable LDLR-independent lipid lowering in vivo.,2026,10.1016/j.ymthe.2026.07.036,https://pubmed.ncbi.nlm.nih.gov/42470100/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,40852369,Asialoglycoprotein receptor 1: a multifaceted receptor in the liver and cardiovascular system.,2025,10.3389/fmed.2025.1653452,https://pubmed.ncbi.nlm.nih.gov/40852369/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,42012509,ASGR1 induces neutrophil extracellular traps formation to exacerbate sepsis-induced myocardial injury and cardiac dysfunction through SLC7A11 ubiquitination.,2026,10.1042/cs20250290,https://pubmed.ncbi.nlm.nih.gov/42012509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,42286817,"Asialoglycoprotein receptor-1 promotes hyperandrogenism in polycystic ovary syndrome through direct interaction with FSHR, leading to cAMP-PKA-CREB pathway inhibition.",2026,10.1093/reprod/xaag073,https://pubmed.ncbi.nlm.nih.gov/42286817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,42858308,Tissue-Specific Isolation of Hepatocyte Extracellular Vesicles From Human Plasma Enables Tissue-Resolved Proteomic and miRNA Profiling.,2026,10.1002/jev2.70372,https://pubmed.ncbi.nlm.nih.gov/42858308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,41885011,Asialoglycoprotein receptor 1 positively regulates PTGS2-induced inflammatory response in polycystic ovary syndrome via ERK1/2 pathway.,2026,10.1093/reprod/xaag026,https://pubmed.ncbi.nlm.nih.gov/41885011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,41761201,Fisetin-loaded nanoparticles as a novel approach for cholesterol regulation in hypercholesterolemia: targeting the ASGR1-mediated mTORC1/AMPK pathway.,2026,10.1186/s12951-026-04181-z,https://pubmed.ncbi.nlm.nih.gov/41761201/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,41841173,Circulating Liver-Derived and CD36&lt;sup&gt;+&lt;/sup&gt; Extracellular Vesicles Correlate With Ectopic Liver Fat and Markers of Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease and Decrease During Weight Loss Intervention.,2026,10.1002/jev2.70257,https://pubmed.ncbi.nlm.nih.gov/41841173/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,41443470,Role and mechanism of ASGR1 in acute liver injury.,2026,10.1016/j.lfs.2025.124157,https://pubmed.ncbi.nlm.nih.gov/41443470/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,41597209,"Gene Editing Therapies Targeting Lipid Metabolism for Cardiovascular Disease: Tools, Delivery Strategies, and Clinical Progress.",2026,10.3390/cells15020134,https://pubmed.ncbi.nlm.nih.gov/41597209/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,41663990,Sex-related differences in gene expression in early-stage bladder cancer revealed by whole-transcriptome sequencing.,2026,10.1186/s12885-026-15666-3,https://pubmed.ncbi.nlm.nih.gov/41663990/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,42596884,DNA methylation informs adult cardiovascular risk and prevention for low birthweight individuals.,2026,10.7189/jogh.16.04242,https://pubmed.ncbi.nlm.nih.gov/42596884/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,42806895,Re: ASGR1 Deficiency Promotes Liver Fibrosis by Enhancing Pro-Inflammatory Arachidonic Acid Metabolism and ALP Secretion.,2026,10.1002/iid3.70543,https://pubmed.ncbi.nlm.nih.gov/42806895/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,42372385,A celastrol derivative-based multifunctional nanozyme for oxidative stress scavenging and lipid metabolism regulation in metabolic dysfunction-associated steatotic liver disease.,2026,10.1016/j.bioadv.2026.215027,https://pubmed.ncbi.nlm.nih.gov/42372385/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,40429734,A High-Throughput Cell-Based Luciferase Reporter Assay for Identifying Inhibitors of ASGR1.,2025,10.3390/ijms26104590,https://pubmed.ncbi.nlm.nih.gov/40429734/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,41062796,"Cholesterol metabolism: molecular mechanisms, biological functions, diseases, and therapeutic targets.",2025,10.1186/s43556-025-00321-3,https://pubmed.ncbi.nlm.nih.gov/41062796/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,41592894,Serum soluble ASGR1 concentration is elevated in patients with metabolic dysfunction-associated steatotic liver disease and is associated with adiponectin.,2026,10.1136/bmjdrc-2025-005638,https://pubmed.ncbi.nlm.nih.gov/41592894/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,41941847,"Molecular mechanisms of DBDPE-induced spermatogenic disorder: A network toxicology, machine learning, and in vivo experimental validation.",2026,10.1016/j.envint.2026.110220,https://pubmed.ncbi.nlm.nih.gov/41941847/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,41968605,An Integrated Nanozyme-Exosome Platform for Multi-Targeted Therapy of Metabolic-Associated Steatotic Liver Disease.,2026,10.1002/adhm.71147,https://pubmed.ncbi.nlm.nih.gov/41968605/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASGR1,ENSG00000141505,Unsafe,39055948,ASGR1 is a promising target for lipid reduction in pigs with PON2 as its inhibitor.,2024,10.1016/j.isci.2024.110288,https://pubmed.ncbi.nlm.nih.gov/39055948/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,42063344,Microcephaly-associated genes asp and Sas4 influence chromatin organization and nuclear lamina structure in Drosophila melanogaster.,2026,10.1242/dev.205125,https://pubmed.ncbi.nlm.nih.gov/42063344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,42152408,ASPM promotes the progression of ovarian endometriosis by modulating the cell cycle and activating the Wnt/β-catenin signaling pathway.,2026,10.1097/md.0000000000048765,https://pubmed.ncbi.nlm.nih.gov/42152408/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,42021279,ASPM promotes the progression of esophageal squamous cell carcinoma by upregulating the expression of HMMR.,2026,10.1186/s12935-026-04300-8,https://pubmed.ncbi.nlm.nih.gov/42021279/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,42025781,The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and development.,2026,10.1016/j.ydbio.2026.04.014,https://pubmed.ncbi.nlm.nih.gov/42025781/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,42004077,Integrated bulk and single-cell transcriptomics with experimental validation to identify calmodulin-related prognostic genes in lung adenocarcinoma.,2026,10.62347/sdlr5143,https://pubmed.ncbi.nlm.nih.gov/42004077/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,42106529,Identification of biomarkers associated with diagnosis of gastroesophageal junction adenocarcinoma and their correlation with immune infiltration.,2026,10.1007/s12672-026-05067-0,https://pubmed.ncbi.nlm.nih.gov/42106529/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,41984993,Worm orthologues of cytokinesis-associated proteins CIT and ASPM regulate neuronal microtubule dynamics and polarity in C. elegans.,2026,10.1371/journal.pgen.1012106,https://pubmed.ncbi.nlm.nih.gov/41984993/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,41728614,Incision of the pre-Descemet layer and Descemet membrane affects outflow facility: &lt;i&gt;ex-vivo&lt;/i&gt; studies on a human eye perfusion model.,2026,10.3389/fmed.2026.1706969,https://pubmed.ncbi.nlm.nih.gov/41728614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,40979592,Assembly factor for spindle microtubules (&lt;i&gt;ASPM&lt;/i&gt;) promotes osimertinib resistance in lung cancer by increasing &lt;i&gt;EGFR&lt;/i&gt; stability.,2025,10.3389/fgene.2025.1593314,https://pubmed.ncbi.nlm.nih.gov/40979592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,42181033,Comparative transcriptomics and computational drug discovery identify ASPM as a key oncogenic driver and therapeutic target in hepatocellular carcinoma.,2026,10.3389/fbinf.2026.1795889,https://pubmed.ncbi.nlm.nih.gov/42181033/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,37599996,The neurological and non-neurological roles of the primary microcephaly-associated protein ASPM.,2023,10.3389/fnins.2023.1242448,https://pubmed.ncbi.nlm.nih.gov/37599996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,41074654,What the fruit fly can tell us about autosomal recessive primary microcephaly.,2025,10.1080/19336934.2025.2572866,https://pubmed.ncbi.nlm.nih.gov/41074654/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,40813497,Identification of mutation in ASPM gene in microcephaly families from Khyber Pakhtunkhwa.,2025,10.1007/s11033-025-10911-7,https://pubmed.ncbi.nlm.nih.gov/40813497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,42478154,An Integrative Methylation-Metabolism Gene Signature Defines Prognosis and Immunosuppressive Microenvironment in Prostate Cancer.,2026,10.1111/cbdd.70360,https://pubmed.ncbi.nlm.nih.gov/42478154/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,42405025,Integrative Transcriptomic Analysis Identifies Hypoxia-responsive Cell Cycle Hub Genes as Prognostic Markers in Glioblastoma.,2026,10.1177/09727531261453688,https://pubmed.ncbi.nlm.nih.gov/42405025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,41520149,Chemotherapy resistance of urinary bladder cancer mediated by a Notch and Wnt co-regulatory module of stemness.,2026,10.1093/stmcls/sxag002,https://pubmed.ncbi.nlm.nih.gov/41520149/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,40122889,ASPM mediates nuclear entrapment of FOXM1 via liquid-liquid phase separation to promote progression of hepatocarcinoma.,2025,10.1186/s13059-025-03526-5,https://pubmed.ncbi.nlm.nih.gov/40122889/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,39344621,[Genetic analysis of a child with autosomal recessive primary microcephaly due to variant of ASPM gene and a literature review].,2024,10.3760/cma.j.cn511374-20240123-00065,https://pubmed.ncbi.nlm.nih.gov/39344621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,42833956,Phenotypic and Genotypic characterization of Indian microcephaly.,2026,10.1016/j.pedneo.2026.06.011,https://pubmed.ncbi.nlm.nih.gov/42833956/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,42797440,Quality by Design-Guided Development of Ketoprofen-Cationic Aspasomes Unlocks the Antifungal Potential of Repurposed Ketoprofen for Topical Therapy.,2026,10.3390/ph19091394,https://pubmed.ncbi.nlm.nih.gov/42797440/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,40898336,CAFs promote immune evasion in gastric cancer through histone lactylation-mediated suppression of NCAPG ubiquitination.,2025,10.1186/s12967-025-07013-0,https://pubmed.ncbi.nlm.nih.gov/40898336/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,42771562,High infiltration level of a prognostic improvement associated T cells is favorable for the prognosis of patients with gastric adenocarcinoma.,2026,10.1159/dig/acmag021,https://pubmed.ncbi.nlm.nih.gov/42771562/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,41555927,Expanding the mutational spectrum of congenital microcephaly in Pakistani families.,2025,10.3389/fgene.2025.1709083,https://pubmed.ncbi.nlm.nih.gov/41555927/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,40202190,Adverse predictive value of ASPM on lung adenocarcinoma overall survival depended on chemotherapy status.,2025,10.1080/20565623.2025.2489328,https://pubmed.ncbi.nlm.nih.gov/40202190/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,41373021,"A core stemness-associated module reveals PLK1, NUF2, KIF23, CDCA8, TOP2A, CENPF, AURKA, and ASPM as key genes in rectal cancer.",2025,10.1186/s40001-025-03649-2,https://pubmed.ncbi.nlm.nih.gov/41373021/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,39445005,Application of a risk score model based on glycosylation-related genes in the prognosis and treatment of patients with low-grade glioma.,2024,10.3389/fimmu.2024.1467858,https://pubmed.ncbi.nlm.nih.gov/39445005/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,42625886,&lt;i&gt;Atractylodes chinensis&lt;/i&gt; polysaccharides downregulate RHEB to confer splenoprotective effects against aging-associated disorders.,2026,10.3389/fphar.2026.1877665,https://pubmed.ncbi.nlm.nih.gov/42625886/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,42179967,An integrative transcriptomic analysis for prognosis and tumor microenvironment in HBV/HCV-associated hepatocellular carcinoma.,2026,10.1016/j.omton.2026.201218,https://pubmed.ncbi.nlm.nih.gov/42179967/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,41751270,Single-Cell Analysis Reveals Epithelial Heterogeneity and Tumor Microenvironment Characteristics During the Malignant Progression of Colorectal Cancer.,2026,10.3390/biomedicines14020371,https://pubmed.ncbi.nlm.nih.gov/41751270/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,42724844,Microplastics and nanoplastics-related genes signature predicts prognosis in pancreatic ductal adenocarcinoma and functional validation of interleukin 1 alpha.,2026,10.21037/tcr-2026-1405,https://pubmed.ncbi.nlm.nih.gov/42724844/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,41751958,FOXM1 Signaling Network Transcriptionally Upregulates Expression of Proteins Involved in Mitotic Progression to Induce High Proliferation and Chromosomal Instability in Androgen Receptor-Low Triple-Negative Breast Cancer.,2026,10.3390/ijms27041823,https://pubmed.ncbi.nlm.nih.gov/41751958/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,39528802,Discovery of key molecular signatures for diagnosis and therapies of glioblastoma by combining supervised and unsupervised learning approaches.,2024,10.1038/s41598-024-79391-2,https://pubmed.ncbi.nlm.nih.gov/39528802/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASPM,ENSG00000066279,Unsafe,41485159,Inflammation-associated immune-related genes as potential biomarkers for the diagnosis of interstitial cystitis.,2026,10.1007/s10238-025-02032-z,https://pubmed.ncbi.nlm.nih.gov/41485159/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,42777023,An ASXL3-thyroid hormone axis in parvalbumin interneurons controls autism-like behaviors.,2026,10.1126/sciadv.aeh2640,https://pubmed.ncbi.nlm.nih.gov/42777023/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,42694808,Two Cases of &lt;i&gt;ASXL3&lt;/i&gt;-Related Bainbridge-Ropers Syndrome: Clinical and Genetic Evaluation.,2026,10.1155/crig/9304690,https://pubmed.ncbi.nlm.nih.gov/42694808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,42194125,Studying Familial Bainbridge-Ropers Syndrome Due to a Novel &lt;i&gt;ASXL3&lt;/i&gt; Germline Variant and Expanding the Clinical Spectrum.,2026,10.3390/children13050599,https://pubmed.ncbi.nlm.nih.gov/42194125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,42880131,Identification of biomarkers related to lymph node metastasis and prognosis in thyroid cancer based on integrated bioinformatics exploration.,2026,10.1016/j.clinsp.2026.101201,https://pubmed.ncbi.nlm.nih.gov/42880131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,41659201,ASXL3 gene variants causing Bainbridge-Ropers syndrome: clinical and genetic analysis of four Chinese patients.,2025,10.3389/fnins.2025.1739877,https://pubmed.ncbi.nlm.nih.gov/41659201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,42494517,Broadening the inherited &lt;i&gt;ASXL3&lt;/i&gt; spectrum and unveiling molecular mechanisms through detailed genotypic-phenotypic analyses.,2026,10.1016/j.gimo.2026.104409,https://pubmed.ncbi.nlm.nih.gov/42494517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,41458212,Case Report: Synergistic effects of an &lt;i&gt;ASXL3&lt;/i&gt; mutation and a 15q11.2 BP1-BP2 microdeletion in a severe neurodevelopmental phenotype.,2025,10.3389/fgene.2025.1674158,https://pubmed.ncbi.nlm.nih.gov/41458212/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,42483169,CD244 overexpression indicates NK cell dysfunction and tumor progression in diffuse large B-cell lymphoma.,2026,10.3389/fimmu.2026.1855521,https://pubmed.ncbi.nlm.nih.gov/42483169/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,40980137,Paternal mosaicism in &lt;i&gt;ASXL3&lt;/i&gt;-related bainbridge-ropers syndrome: implications for genetic counseling and prenatal diagnosis.,2025,10.3389/fped.2025.1655021,https://pubmed.ncbi.nlm.nih.gov/40980137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,41888098,BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia.,2026,10.1038/s41419-026-08650-z,https://pubmed.ncbi.nlm.nih.gov/41888098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,39610869,Four heterozygous de novo variants in ASXL3 identified with Bainbridge-Ropers syndrome and further dissecting published genotype-phenotype spectrum.,2024,10.3389/fnins.2024.1456433,https://pubmed.ncbi.nlm.nih.gov/39610869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,40799249,Case Report: A familial hematological pedigree reveals VHL germline mutation as a principal predisposition factor with additional mutations modulating phenotypic heterogeneity.,2025,10.3389/fonc.2025.1630715,https://pubmed.ncbi.nlm.nih.gov/40799249/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,40891523,Speech and Language Development of Two Brothers With Bainbridge-Ropers Syndrome: Phenotypic and Bioinformatic Support for a Cerebellar ASXL3 Hypothesis.,2026,10.1002/ajmg.a.64240,https://pubmed.ncbi.nlm.nih.gov/40891523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,41146021,A novel ASXL3 gene variant in a Chinese Boy causing Bainbridge.,2025,10.1186/s12879-025-11611-0,https://pubmed.ncbi.nlm.nih.gov/41146021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,40808361,"Assessing Pubertal Timing, Duration, and Related Characteristics in ASXL-Related Disorders: A Cross-Sectional Caregiver Survey Analysis.",2026,10.1002/ajmg.a.64216,https://pubmed.ncbi.nlm.nih.gov/40808361/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,41134724,Genetic Characterization of 128 Chinese Individuals with Neurodevelopmental Disorders via Whole-Exome Sequencing.,2025,10.1159/000549155,https://pubmed.ncbi.nlm.nih.gov/41134724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,40282252,Integration of Microarray and Single-Cell RNA-Seq Data and Machine Learning Allows the Identification of Key Histone Modification Gene Changes in Spermatogonial Stem Cells.,2025,10.3390/biology14040387,https://pubmed.ncbi.nlm.nih.gov/40282252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,40943102,Genome-Wide Association Study of Osteoporosis Risk in Korean Pre-Menopausal Women: The Korean Genome and Epidemiology Study.,2025,10.3390/ijms26178177,https://pubmed.ncbi.nlm.nih.gov/40943102/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,40098664,Multi-level genomic convergence of secondary aquatic adaptation in marine mammals.,2025,10.1016/j.xinn.2025.100798,https://pubmed.ncbi.nlm.nih.gov/40098664/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,38711055,An adolescent case of ASXL3-related disorder with delayed onset of feeding difficulty.,2024,10.1186/s12887-024-04774-3,https://pubmed.ncbi.nlm.nih.gov/38711055/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,42031194,Mouse embryos as In Vivo models for proteomic identification and functional analysis of missing proteins.,2026,10.1016/j.ab.2026.116138,https://pubmed.ncbi.nlm.nih.gov/42031194/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,40046420,Comprehensive investigation of gene mutations in canine large cell gastrointestinal lymphoma.,2025,10.3389/fvets.2025.1535446,https://pubmed.ncbi.nlm.nih.gov/40046420/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,38027485,Examining the neurodevelopmental and motor phenotypes of Bohring-Opitz syndrome (ASXL1) and Bainbridge-Ropers syndrome (ASXL3).,2023,10.3389/fnins.2023.1244176,https://pubmed.ncbi.nlm.nih.gov/38027485/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,38982123,Sex-specific survival gene mutations are discovered as clinical predictors of clear cell renal cell carcinoma.,2024,10.1038/s41598-024-66525-9,https://pubmed.ncbi.nlm.nih.gov/38982123/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,35172777,A case of Bainbridge-Ropers syndrome with breath holding spells and intractable epilepsy: challenges in diagnosis and management.,2022,10.1186/s12883-022-02573-w,https://pubmed.ncbi.nlm.nih.gov/35172777/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,32695399,Plasma circulating tumor DNA assessment reveals KMT2D as a potential poor prognostic factor in extranodal NK/T-cell lymphoma.,2020,10.1186/s40364-020-00205-4,https://pubmed.ncbi.nlm.nih.gov/32695399/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,36611251,Genomic Profiling Reveals the Variant Landscape of Sporadic Parathyroid Adenomas in Chinese Population.,2023,10.1210/clinem/dgad002,https://pubmed.ncbi.nlm.nih.gov/36611251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,34536950,ASXL1 promotes adrenocortical carcinoma and is associated with chemoresistance to EDP regimen.,2021,10.18632/aging.203534,https://pubmed.ncbi.nlm.nih.gov/34536950/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,28785287,Novel compound heterozygous ASXL3 mutation causing Bainbridge-ropers like syndrome and primary IGF1 deficiency.,2017,10.1186/s13633-017-0047-9,https://pubmed.ncbi.nlm.nih.gov/28785287/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,32091413,Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer.,2020,10.1172/jci131041,https://pubmed.ncbi.nlm.nih.gov/32091413/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,30359545,Identification of a novel PDGFRA point mutation at p.P6L as a potential molecular target of imatinib in an eosinophilia patient showing genetic heterogeneity.,2019,10.1080/15384047.2018.1532558,https://pubmed.ncbi.nlm.nih.gov/30359545/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,23736028,Functional and cancer genomics of ASXL family members.,2013,10.1038/bjc.2013.281,https://pubmed.ncbi.nlm.nih.gov/23736028/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,26192917,Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma.,2015,10.1038/ng.3358,https://pubmed.ncbi.nlm.nih.gov/26192917/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ASXL3,ENSG00000141431,Unsafe,15138607,Identification and characterization of ASXL3 gene in silico.,2004,,https://pubmed.ncbi.nlm.nih.gov/15138607/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,42810092,Integrated genomic and transcriptomic analysis reveals candidate genes associated with reproductive performance in Hetian Black chickens.,2026,10.1016/j.psj.2026.107850,https://pubmed.ncbi.nlm.nih.gov/42810092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,41927050,Functional characterization of porcine septin12 and its role in male reproduction.,2026,10.5713/ab.250538,https://pubmed.ncbi.nlm.nih.gov/41927050/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,42349120,"A three-gene signature (ABCE1, ATAD5, FUT4) for colorectal cancer prognosis: integrative analysis of transcriptomic, single-cell, and machine learning data.",2026,10.1016/j.bbrc.2026.154124,https://pubmed.ncbi.nlm.nih.gov/42349120/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,41664698,Novel mechanism of tumor metastasis: DDX11-ATAD5 interaction mediates epithelial-mesenchymal transition to promote gallbladder cancer progression.,2025,10.25259/cytojournal_42_2025,https://pubmed.ncbi.nlm.nih.gov/41664698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,42575442,Mechanistic diversity of clamp loading at small DNA gaps.,2026,10.1016/j.jbc.2026.113397,https://pubmed.ncbi.nlm.nih.gov/42575442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,42242683,Identification and characterization of lncRNA-stemness-immune regulatory patterns.,2026,10.1093/bib/bbag287,https://pubmed.ncbi.nlm.nih.gov/42242683/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,38871854,The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader.,2024,10.1038/s41594-024-01332-4,https://pubmed.ncbi.nlm.nih.gov/38871854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,42585314,CDT1 acts with the replisome to remodel replication forks.,2026,10.1126/sciadv.aee6914,https://pubmed.ncbi.nlm.nih.gov/42585314/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,40766329,Targeting PDCD4 in cancer and atrial fibrillation: mechanistic insights from integrated multi-omics and single-cell analysis.,2025,10.3389/fonc.2025.1593815,https://pubmed.ncbi.nlm.nih.gov/40766329/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,39145935,ATAD5 functions as a regulatory platform for Ub-PCNA deubiquitination.,2024,10.1073/pnas.2315759121,https://pubmed.ncbi.nlm.nih.gov/39145935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,42839733,Methylmalonic Acid Induces Oxaliplatin Resistance Through Promoting DNA Damage Repair via the ATM/ATR Pathway in Gastric Cancer.,2026,10.1096/fj.202600528r,https://pubmed.ncbi.nlm.nih.gov/42839733/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,38141767,The Atad5 RFC-like complex is the major unloader of proliferating cell nuclear antigen in Xenopus egg extracts.,2024,10.1016/j.jbc.2023.105588,https://pubmed.ncbi.nlm.nih.gov/38141767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,41496077,Mendelian randomization identifies circulating miRNAs as causal mediators of gastric cancer susceptibility and survival outcomes.,2026,10.1097/md.0000000000046833,https://pubmed.ncbi.nlm.nih.gov/41496077/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,39627214,ATAD5-BAZ1B interaction modulates PCNA ubiquitination during DNA repair.,2024,10.1038/s41467-024-55005-3,https://pubmed.ncbi.nlm.nih.gov/39627214/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,41606318,PAF15-PCNA exhaustion governs the strand-specific control of DNA replication.,2026,10.1038/s41586-025-10011-3,https://pubmed.ncbi.nlm.nih.gov/41606318/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,41899279,Associations of Tumor Somatic Mutations and Genetic Alterations with Survival Outcomes in Melanoma Patients Treated with Ipilimumab.,2026,10.3390/jcm15062355,https://pubmed.ncbi.nlm.nih.gov/41899279/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,42724404,Mutational signature stratification of recurrent gliomas reveals distinct patterns of genomic traits.,2026,10.1093/noajnl/vdag188,https://pubmed.ncbi.nlm.nih.gov/42724404/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,39664055,Therapeutic effects and mechanisms of berberine on enteritis caused by Salmonella in poultry.,2024,10.3389/fmicb.2024.1458579,https://pubmed.ncbi.nlm.nih.gov/39664055/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,36734974,The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5.,2023,10.7554/elife.79013,https://pubmed.ncbi.nlm.nih.gov/36734974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,42433452,Target deconvolution of a selective HepG2 cytotoxic hit identifies GSTP1 and TRAP1 as candidate molecular targets.,2026,10.1039/d6ra04601k,https://pubmed.ncbi.nlm.nih.gov/42433452/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,42438047,Combined molecular fingerprint and descriptor features enable classical machine learning to match deep learning performance across the Tox21 toxicity panel.,2026,10.1080/15376516.2026.2703006,https://pubmed.ncbi.nlm.nih.gov/42438047/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,41801511,Disrupting the USP1-UAF1 deubiquitinase complex: a master regulator of replication stress and frontier target in cancer therapy.,2026,10.1007/s12032-026-03281-y,https://pubmed.ncbi.nlm.nih.gov/41801511/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,32297953,ATAD5 deficiency alters DNA damage metabolism and sensitizes cells to PARP inhibition.,2020,10.1093/nar/gkaa255,https://pubmed.ncbi.nlm.nih.gov/32297953/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,38542333,PCNA Unloading Is Crucial for the Bypass of DNA Lesions Using Homologous Recombination.,2024,10.3390/ijms25063359,https://pubmed.ncbi.nlm.nih.gov/38542333/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,37854190,Specific genetic aberrations of parathyroid in Chinese patients with tertiary hyperparathyroidism using whole-exome sequencing.,2023,10.3389/fendo.2023.1221060,https://pubmed.ncbi.nlm.nih.gov/37854190/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,34751190,Characterization of subcellular localization of eukaryotic clamp loader/unloader and its regulatory mechanism.,2021,10.1038/s41598-021-01336-w,https://pubmed.ncbi.nlm.nih.gov/34751190/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,26177013,Regulation of Elg1 activity by phosphorylation.,2015,10.1080/15384101.2015.1068475,https://pubmed.ncbi.nlm.nih.gov/26177013/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,33188484,Identification of immune-related gene signature predicting survival in the tumor microenvironment of lung adenocarcinoma.,2020,10.1007/s00251-020-01189-z,https://pubmed.ncbi.nlm.nih.gov/33188484/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATAD5,ENSG00000176208,Unsafe,35236804,Development of in silico prediction models for drug-induced liver malignant tumors based on the activity of molecular initiating events: Biologically interpretable features.,2022,10.2131/jts.47.89,https://pubmed.ncbi.nlm.nih.gov/35236804/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,42650020,"Variations in Autophagy-Related Genes &lt;i&gt;ATG5, ATG10&lt;/i&gt; and &lt;i&gt;ATG16L1&lt;/i&gt; Correlate with Tumor Burden, Inflammatory Biomarkers and Clinical Course in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors.",2026,10.3390/cancers18162709,https://pubmed.ncbi.nlm.nih.gov/42650020/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,42528070,HY5 Positively Regulates Autophagy to Mediate Red Light-Induced Tomato Fruit Ripening.,2026,10.1111/pbi.70732,https://pubmed.ncbi.nlm.nih.gov/42528070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,42465021,Erratum: ATG10 overexpression is related to the dismal prognosis and promotes the growth and migration of hepatocellular carcinoma cells via cyclin B1/CDK1 and CDK2.,2026,10.62347/rfyi1135,https://pubmed.ncbi.nlm.nih.gov/42465021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,42278149,The SQSTM1/&lt;i&gt;p62&lt;/i&gt; of Pacific White Shrimp (&lt;i&gt;Litopenaeus vannamei&lt;/i&gt;) Is Involved in the Oxidative Stress Induced by Ammonia Exposure.,2026,10.3390/ani16111718,https://pubmed.ncbi.nlm.nih.gov/42278149/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,42828824,Integrative analysis of immune-cell eQTLs and Mendelian randomization identifies genetically supported genes associated with breast cancer susceptibility.,2026,10.1016/j.cancergen.2026.09.007,https://pubmed.ncbi.nlm.nih.gov/42828824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,39407279,METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1.,2024,10.1186/s13062-024-00536-4,https://pubmed.ncbi.nlm.nih.gov/39407279/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,42141163,Atg7-Atg12 conjugation and autophagy are negatively regulated by the disordered region of Atg12.,2026,10.1038/s42003-026-10269-x,https://pubmed.ncbi.nlm.nih.gov/42141163/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,42502305,Autophagy-Related Gene-Set Signals in the Genetic Architecture of Obsessive-Compulsive Disorder: A Hypothesis-Generating Link to Nicotinamide Adenine Dinucleotide-Associated Cellular Maintenance Biology.,2026,10.7759/cureus.113327,https://pubmed.ncbi.nlm.nih.gov/42502305/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,40313244,A review shows that ATG10 has been identified as a potential prognostic marker and therapeutic target for cancer patients based on real-world studies.,2025,10.3389/fonc.2025.1573378,https://pubmed.ncbi.nlm.nih.gov/40313244/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,41318379,"Interplay between autophagy, the unfolded protein response and the cytoplasmic heat stress response during heat stress in maize.",2025,10.1186/s12870-025-07736-8,https://pubmed.ncbi.nlm.nih.gov/41318379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,39736548,Potential involvement of cuproptosis induced by m6A-modified autophagy gene ATG10 in KICH : Cuproptosis induced by m6A-modified ATG10 in KICH.,2024,10.1186/s12885-024-13300-8,https://pubmed.ncbi.nlm.nih.gov/39736548/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,42144735,Dual mechanism of human ATG10S in suppressing MEF2A-Driven pro-inflammatory responses.,2026,10.1080/15548627.2026.2676074,https://pubmed.ncbi.nlm.nih.gov/42144735/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,39715205,ATRA-induced NEAT1 upregulation promotes autophagy during APL cell granulocytic differentiation.,2024,10.1371/journal.pone.0316109,https://pubmed.ncbi.nlm.nih.gov/39715205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,42014011,miR-329-3p derived from mast cells-exosomes exacerbates intestinal ischemia-reperfusion injury by targeting ATG10 to regulate autophagy.,2026,10.1016/j.ijbiomac.2026.152091,https://pubmed.ncbi.nlm.nih.gov/42014011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,40750811,Influence of ATG SNPs on hip fracture patients' functional status.,2025,10.1038/s41598-025-13455-9,https://pubmed.ncbi.nlm.nih.gov/40750811/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,41108073,The HsfA1a-BAG5b module mediates thermotolerance through activating autophagy in tomato.,2025,10.1093/plphys/kiaf526,https://pubmed.ncbi.nlm.nih.gov/41108073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,40743646,A combined therapeutic approach: Parthenolide and vincristine modulate autophagy in B-cell acute lymphoblastic leukemia.,2025,10.1016/j.tice.2025.103057,https://pubmed.ncbi.nlm.nih.gov/40743646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,42102270,Chloroplast stress caused by maltose hyperaccumulation activates chlorophagy via the core autophagy machinery.,2026,10.1093/plphys/kiag271,https://pubmed.ncbi.nlm.nih.gov/42102270/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,40832611,"Revealing key regulatory factors in lung adenocarcinoma: the role of epigenetic regulation of autophagy-related genes from transcriptomics, scRNA-seq, and machine learning.",2025,10.3389/fphar.2025.1542338,https://pubmed.ncbi.nlm.nih.gov/40832611/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,42737793,"Genome-Wide Differentiation, Inbreeding, and Candidate Selection Loci in Local Vietnamese Pig Breeds.",2026,10.3390/ijms27177897,https://pubmed.ncbi.nlm.nih.gov/42737793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,39110225,"ATG10-dependent autophagy is required for DDX10 to regulate cell proliferation, apoptosis and stemness in colorectal cancer.",2024,10.1007/s00432-024-05910-3,https://pubmed.ncbi.nlm.nih.gov/39110225/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,38327458,LncRNA Zfas1 boosts cell apoptosis and autophagy in myocardial injury induced by hypoxia via miR-383-5p/ATG10 axis.,2024,10.1016/j.heliyon.2024.e24578,https://pubmed.ncbi.nlm.nih.gov/38327458/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,38590415,"Multi-omics Mendelian randomization integrating GWAS, eQTL, and mQTL data identified genes associated with breast cancer.",2024,10.62347/bczw1355,https://pubmed.ncbi.nlm.nih.gov/38590415/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,37168332,ATG10 overexpression is related to the dismal prognosis and promotes the growth and migration of hepatocellular carcinoma cells via cyclin B1/CDK1 and CDK2.,2023,,https://pubmed.ncbi.nlm.nih.gov/37168332/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,37708952,Genetic markers associated with adverse reactions of radioiodine therapy in thyroid cancer patients.,2023,10.1515/dmpt-2023-0007,https://pubmed.ncbi.nlm.nih.gov/37708952/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,37381702,Genetic markers associated with adverse reactions of radioiodine therapy in thyroid cancer patients.,2023,10.1515/dmdi-2023-0007,https://pubmed.ncbi.nlm.nih.gov/37381702/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,37077914,Establishment and validation of exhausted CD8+ T cell feature as a prognostic model of HCC.,2023,10.3389/fimmu.2023.1166052,https://pubmed.ncbi.nlm.nih.gov/37077914/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,35349097,SNHG14 Upregulation Was a Molecular Mechanism Underlying MPP&lt;sup&gt;+&lt;/sup&gt; Neurotoxicity in Dopaminergic SK-N-SH Cells via SNHG14-miR-519a-3p-ATG10 ceRNA Pathway.,2022,10.1007/s12640-022-00488-5,https://pubmed.ncbi.nlm.nih.gov/35349097/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,39615108,Inhibiting autophagy enhances idarubicin chemosensitivity and induces immune escape in FAT1-low-expressing AML cells.,2025,10.1016/j.intimp.2024.113484,https://pubmed.ncbi.nlm.nih.gov/39615108/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,35999759,Recent evidence for toxic effects of NH&lt;sub&gt;3&lt;/sub&gt; exposure on lung injury: Protective effects of L-selenomethionine.,2022,10.1016/j.ecoenv.2022.113937,https://pubmed.ncbi.nlm.nih.gov/35999759/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATG10,ENSG00000152348,Unsafe,39958919,Single-cell and machine learning approaches uncover intrinsic immune-evasion genes in the prognosis of hepatocellular carcinoma.,2024,10.1016/j.livres.2024.11.001,https://pubmed.ncbi.nlm.nih.gov/39958919/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,42381520,Biallelic Variants in ATP1A4 Are Associated with Oligoasthenoteratozoospermia and Male Infertility.,2026,10.1111/cge.70205,https://pubmed.ncbi.nlm.nih.gov/42381520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,41626717,Parallel Erosion of a Testis-Specific Na+/K+ ATPase in Three Mammalian Lineages Sheds Light into the Evolution of Spermatozoa Energetics.,2026,10.1093/gbe/evaf246,https://pubmed.ncbi.nlm.nih.gov/41626717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,35887284,Testis-Specific Isoform of Na+-K+ ATPase and Regulation of Bull Fertility.,2022,10.3390/ijms23147936,https://pubmed.ncbi.nlm.nih.gov/35887284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,42612345,Mineral-driven molecular signatures of energy metabolism underpin sperm motility in buffalo.,2026,10.1016/j.anireprosci.2026.108307,https://pubmed.ncbi.nlm.nih.gov/42612345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,40558505,&lt;i&gt;Atp1b2&lt;sup&gt;Atp1b1&lt;/sup&gt;&lt;/i&gt; Knock-In Mice Exhibit a Cone-Rod Dystrophy-Like Phenotype.,2025,10.3390/cells14120878,https://pubmed.ncbi.nlm.nih.gov/40558505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,33977467,"Na,K-ATPase Atp1a4 isoform is important for maintaining sperm flagellar shape.",2021,10.1007/s10815-021-02087-3,https://pubmed.ncbi.nlm.nih.gov/33977467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,40930156,Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation.,2026,10.1113/jp287928,https://pubmed.ncbi.nlm.nih.gov/40930156/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,36077468,Membrane-Bound EMC10 Is Required for Sperm Motility via Maintaining the Homeostasis of Cytoplasm Sodium in Sperm.,2022,10.3390/ijms231710069,https://pubmed.ncbi.nlm.nih.gov/36077468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,32588885,The Na+ and K+ transport system of sperm (ATP1A4) is essential for male fertility and an attractive target for male contraception†.,2020,10.1093/biolre/ioaa093,https://pubmed.ncbi.nlm.nih.gov/32588885/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,42121140,Distinct genetic architecture of coronary heart disease in dyslipidemia patients.,2026,10.1186/s12920-026-02388-5,https://pubmed.ncbi.nlm.nih.gov/42121140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,33885964,Ouabain-induced activation of phospholipase C zeta and its contributions to bovine sperm capacitation.,2021,10.1007/s00441-021-03455-2,https://pubmed.ncbi.nlm.nih.gov/33885964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,30633937,Molecular cloning and characterization of porcine Na⁺/K⁺-ATPase isoform α4.,2019,10.1016/j.biochi.2019.01.003,https://pubmed.ncbi.nlm.nih.gov/30633937/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,36249829,Na/K-ATPase and Regulation of Sperm Function.,2018,10.21451/1984-3143-ar2018-0024,https://pubmed.ncbi.nlm.nih.gov/36249829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,40169113,An in silico analysis of dicofol-induced neurotoxicity mechanisms in humans.,2025,10.1016/j.ntt.2025.107447,https://pubmed.ncbi.nlm.nih.gov/40169113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,31261667,Testis-Specific Isoform of Na/K-ATPase (ATP1A4) Interactome in Raft and Non-Raft Membrane Fractions from Capacitated Bovine Sperm.,2019,10.3390/ijms20133159,https://pubmed.ncbi.nlm.nih.gov/31261667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,39833541,Whole Exome Sequencing Reveals Candidate Variants in Ion Channel Genes for Pelvic Muscle Dysfunction in Young Females with a Family History.,2025,10.1007/s00192-025-06048-7,https://pubmed.ncbi.nlm.nih.gov/39833541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,32549268,Familial Hemiplegic Migraine with an ATP1A4 Mutation: Clinical Spectrum and Carbamazepine Efficacy.,2020,10.3390/brainsci10060372,https://pubmed.ncbi.nlm.nih.gov/32549268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,27807702,Content of testis-specific isoform of Na/K-ATPase (ATP1A4) is increased during bovine sperm capacitation through translation in mitochondrial ribosomes.,2017,10.1007/s00441-016-2514-7,https://pubmed.ncbi.nlm.nih.gov/27807702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,28597551,"Testis-specific isoform of Na/K-ATPase (ATP1A4) regulates sperm function and fertility in dairy bulls through potential mechanisms involving reactive oxygen species, calcium and actin polymerization.",2017,10.1111/andr.12377,https://pubmed.ncbi.nlm.nih.gov/28597551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,32684846,Comprehensive analysis of the expression of sodium/potassium-ATPase α subunits and prognosis of ovarian serous cystadenocarcinoma.,2020,10.1186/s12935-020-01414-5,https://pubmed.ncbi.nlm.nih.gov/32684846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,37141450,Advances in non-hormonal male contraception targeting sperm motility.,2023,10.1093/humupd/dmad008,https://pubmed.ncbi.nlm.nih.gov/37141450/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,19834983,Na+/K+ATPase regulates sperm capacitation through a mechanism involving kinases and redistribution of its testis-specific isoform.,2010,10.1002/mrd.21114,https://pubmed.ncbi.nlm.nih.gov/19834983/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,16861705,"The Na,K-ATPase alpha4 isoform from humans has distinct enzymatic properties and is important for sperm motility.",2006,10.1093/molehr/gal062,https://pubmed.ncbi.nlm.nih.gov/16861705/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP1A4,ENSG00000132681,Unsafe,16175638,"The human Na,K-ATPase alpha 4 isoform is a ouabain-sensitive alpha isoform that is expressed in sperm.",2006,10.1002/mrd.20383,https://pubmed.ncbi.nlm.nih.gov/16175638/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,42669487,ATP6L impairs vascular stability in colorectal cancer via PDGFB/PDGFRβ signaling.,2026,10.5582/bst.2026.01202,https://pubmed.ncbi.nlm.nih.gov/42669487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,42023031,Vacuolar ATPase subunit Atp6v0c transgene promotes neuroprotection and long-distance axon regeneration in injured retinal ganglion neurons.,2026,10.1016/j.omtn.2026.102922,https://pubmed.ncbi.nlm.nih.gov/42023031/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,42625368,The maize CMS-C fertility restore gene ZmRf4b encodes a SPL transcription factor that represses ZmMAP1D-mediated co-translational turnover of mitochondrial toxic ATP6C protein.,2026,10.1016/j.molp.2026.08.016,https://pubmed.ncbi.nlm.nih.gov/42625368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,41738275,ATP6V0C-HIF-1α reciprocal activation drives acute lung injury.,2026,10.1093/ajrcmb/aanag016,https://pubmed.ncbi.nlm.nih.gov/41738275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,42374161,Dysregulation of the TFEB-ATP6V0C axis in microglia exacerbates α-synuclein pathology through impaired lysosomal acidification in Parkinson's disease.,2026,10.1038/s41418-026-01800-y,https://pubmed.ncbi.nlm.nih.gov/42374161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,42636084,Targeting the NR1D1-IGF2BP2-V-ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis-Induced Immunosuppression.,2026,10.1002/advs.77366,https://pubmed.ncbi.nlm.nih.gov/42636084/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,42526150,Epilepsy with fever-sensitivity in patients with ATP6V0C pathogenic variants.,2026,10.1016/j.seizure.2026.07.023,https://pubmed.ncbi.nlm.nih.gov/42526150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,41838682,Bafilomycin A1 is a promising therapeutic agent against T. spiralis infection by inhibiting the heme-transporting ATP6V0C/HRG-1 complex.,2026,10.1371/journal.ppat.1014042,https://pubmed.ncbi.nlm.nih.gov/41838682/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,41349538,Palindrome-mediated 16p13.3 triplications cause a recognizable neurodegenerative disorder with ataxia.,2026,10.1016/j.ajhg.2025.11.011,https://pubmed.ncbi.nlm.nih.gov/41349538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,41545373,Multiscale imaging on proton pump-driven acidity for assessing tumor progression and metastasis.,2026,10.1038/s41467-026-68491-4,https://pubmed.ncbi.nlm.nih.gov/41545373/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,42875556,MD2-IN-1 restores microglial lysosomal function and attenuates amyloid pathology through TREM2-associated signaling in 5×FAD mice.,2026,10.1038/s41401-026-01930-6,https://pubmed.ncbi.nlm.nih.gov/42875556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,39992588,Identification and Validation of Biomarkers for Alzheimer's Disease Based on Akt and Wnt Signaling Pathways in Mouse Models.,2025,10.1007/s12035-025-04785-w,https://pubmed.ncbi.nlm.nih.gov/39992588/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,41904574,Platelet proteomic signatures of amyloid β-positive mild cognitive impairment and Alzheimer's disease.,2026,10.1186/s13041-026-01294-2,https://pubmed.ncbi.nlm.nih.gov/41904574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,40085430,Variants in ATP6V0C are associated with Dravet-like developmental and epileptic encephalopathy.,2025,10.1111/epi.18346,https://pubmed.ncbi.nlm.nih.gov/40085430/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,42108978,Granular Cell Dermatofibroma Demonstrates Loss-of-Function Mutations in V-ATPase Component Genes.,2026,10.1111/cup.70134,https://pubmed.ncbi.nlm.nih.gov/42108978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,41500156,Integrated proteomic and metabolomic analyses reveal testicular metabolic mechanisms underlying sperm quality in drakes.,2026,10.1016/j.psj.2025.106349,https://pubmed.ncbi.nlm.nih.gov/41500156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,41613942,Exploring the effect of skim milk on the membrane stability of frozen-thawed Inner Mongolia cashmere goat sperm based on proteomics.,2025,10.3389/fcell.2025.1701830,https://pubmed.ncbi.nlm.nih.gov/41613942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,38073308,A P-type pentatricopeptide repeat protein ZmRF5 promotes 5' region partial cleavages of atp6c transcripts to restore the fertility of CMS-C maize by recruiting a splicing factor.,2024,10.1111/pbi.14263,https://pubmed.ncbi.nlm.nih.gov/38073308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,40865743,The secondary effects of Vibrio parahaemolyticus on noble scallop Chlamys nobilis with black shell disease.,2025,10.1016/j.fsi.2025.110684,https://pubmed.ncbi.nlm.nih.gov/40865743/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,40858643,Genome sequencing provides high diagnostic yield and new etiological insights for intellectual disability and developmental delay.,2025,10.1038/s41525-025-00521-4,https://pubmed.ncbi.nlm.nih.gov/40858643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,36843263,Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease.,2023,10.1080/15548627.2023.2181614,https://pubmed.ncbi.nlm.nih.gov/36843263/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,39138191,Prosapogenin A induces GSDME-dependent pyroptosis of anaplastic thyroid cancer through vacuolar ATPase activation-mediated lysosomal over-acidification.,2024,10.1038/s41419-024-06985-z,https://pubmed.ncbi.nlm.nih.gov/39138191/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,39919594,Auxin signaling related to H&lt;sup&gt;+&lt;/sup&gt;-ATPase synthesis and antioxidant enzyme activities regulates fluoranthene uptake by ryegrass roots.,2025,10.1016/j.ecoenv.2025.117840,https://pubmed.ncbi.nlm.nih.gov/39919594/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,38935533,FATTY ACID DESATURASE4 enhances plant RNA virus replication and undergoes host vacuolar ATPase-mediated degradation.,2024,10.1093/plphys/kiae350,https://pubmed.ncbi.nlm.nih.gov/38935533/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,41341830,Machine learning integration identifying an eight-gene diagnostic signature for acute mountain sickness.,2025,10.3389/fmed.2025.1688025,https://pubmed.ncbi.nlm.nih.gov/41341830/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,38997273,High frequency electrical stimulation reduces α-synuclein levels and α-synuclein-mediated autophagy dysfunction.,2024,10.1038/s41598-024-64131-3,https://pubmed.ncbi.nlm.nih.gov/38997273/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,38139823,Cranberry Proanthocyanidins Mitigate Reflux-Induced Transporter Dysregulation in an Esophageal Adenocarcinoma Model.,2023,10.3390/ph16121697,https://pubmed.ncbi.nlm.nih.gov/38139823/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,38172607,The Rogdi knockout mouse is a model for Kohlschütter-Tönz syndrome.,2024,10.1038/s41598-023-50870-2,https://pubmed.ncbi.nlm.nih.gov/38172607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,33253518,Effects of Particulate Matter 10 Inhalation on Lung Tissue RNA expression in a Murine Model.,2021,10.4046/trd.2020.0107,https://pubmed.ncbi.nlm.nih.gov/33253518/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,36245484,Functional role of cyanidin-3-O-glucoside in osteogenesis: A pilot study based on RNA-seq analysis.,2022,10.3389/fnut.2022.995643,https://pubmed.ncbi.nlm.nih.gov/36245484/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,35883386,Identification of Body Size Determination Related Candidate Genes in Domestic Pig Using Genome-Wide Selection Signal Analysis.,2022,10.3390/ani12141839,https://pubmed.ncbi.nlm.nih.gov/35883386/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,32059455,The Application of Flexible Areas of Interest to Pilot Mobile Eye Tracking.,2020,10.3390/s20040986,https://pubmed.ncbi.nlm.nih.gov/32059455/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,24385903,Systematic microRNA analysis identifies ATP6V0C as an essential host factor for human cytomegalovirus replication.,2013,10.1371/journal.ppat.1003820,https://pubmed.ncbi.nlm.nih.gov/24385903/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V0C,ENSG00000185883,Unsafe,30597645,Frequent mutations of genes encoding vacuolar H+ -ATPase components in granular cell tumors.,2019,10.1002/gcc.22727,https://pubmed.ncbi.nlm.nih.gov/30597645/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V1E2,ENSG00000250565,Unsafe,41641259,Association between &lt;i&gt;EPAS1&lt;/i&gt; and &lt;i&gt;ATP6V1E2&lt;/i&gt; polymorphisms and susceptibility to high altitude polycythemia in Chinese Tibetan population.,2025,10.3389/fmed.2025.1737704,https://pubmed.ncbi.nlm.nih.gov/41641259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V1E2,ENSG00000250565,Unsafe,40587077,Autophagy-related biomarkers in non-obstructive azoospermia: insights from transcriptomics and single-cell sequencing.,2025,10.1007/s10815-025-03559-6,https://pubmed.ncbi.nlm.nih.gov/40587077/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V1E2,ENSG00000250565,Unsafe,40086029,Transcriptomic and metabolic profiling reveals the effects of long-term microwave exposure on testicular tissue.,2025,10.1016/j.ecoenv.2025.118040,https://pubmed.ncbi.nlm.nih.gov/40086029/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V1E2,ENSG00000250565,Unsafe,40442258,The involvement of the synaptic vesicle cycle in homocysteine induced neurotoxicity in vitro and in vivo.,2025,10.1038/s41598-025-98306-3,https://pubmed.ncbi.nlm.nih.gov/40442258/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V1E2,ENSG00000250565,Unsafe,42866915,Identifying Potential Drug Targets for Treating ADHD From a Genetic Perspective: A Mendelian Randomization Study.,2026,10.1017/thg.2026.10106,https://pubmed.ncbi.nlm.nih.gov/42866915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V1E2,ENSG00000250565,Unsafe,40635857,"WGCNA combined with machine learning to explore potential biomarkers and treatment strategies for acute liver failure, with experimental validation.",2024,10.1016/j.iliver.2024.100133,https://pubmed.ncbi.nlm.nih.gov/40635857/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V1E2,ENSG00000250565,Unsafe,38856651,Reduced vacuolar ATPase protects mice from Friend virus infection - an unintended but instructive effect in Hif-2afl mice.,2024,10.1242/jcs.261893,https://pubmed.ncbi.nlm.nih.gov/38856651/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V1E2,ENSG00000250565,Unsafe,38238328,Investigation of genetic determinants of cognitive change in later life.,2024,10.1038/s41398-023-02726-6,https://pubmed.ncbi.nlm.nih.gov/38238328/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V1E2,ENSG00000250565,Unsafe,40023422,The DHH-DHHA1 domain phosphodiesterase of Mycoplasma bovis employs multiple strategies to modulate macrophage cellular processes.,2025,10.1016/j.ijbiomac.2025.141585,https://pubmed.ncbi.nlm.nih.gov/40023422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V1E2,ENSG00000250565,Unsafe,33194650,Comprehensive Analysis of ATP6V1s Family Members in Renal Clear Cell Carcinoma With Prognostic Values.,2020,10.3389/fonc.2020.567970,https://pubmed.ncbi.nlm.nih.gov/33194650/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V1E2,ENSG00000250565,Unsafe,12036578,"A human gene, ATP6E1, encoding a testis-specific isoform of H(+)-ATPase subunit E.",2002,10.1016/s0378-1119(02)00542-5,https://pubmed.ncbi.nlm.nih.gov/12036578/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V1E2,ENSG00000250565,Unsafe,11872743,A proton pump ATPase with testis-specific E1-subunit isoform required for acrosome acidification.,2002,10.1074/jbc.m111567200,https://pubmed.ncbi.nlm.nih.gov/11872743/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP6V1E2,ENSG00000250565,Unsafe,16192400,Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis.,2006,10.1095/biolreprod.105.043752,https://pubmed.ncbi.nlm.nih.gov/16192400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,42491662,Phospholipid flippases ATP8A1 and ATP8A2 regulate GABA&lt;sub&gt;A&lt;/sub&gt; receptor trafficking through distinct mechanisms in hippocampal neurons.,2026,10.1016/j.isci.2026.116626,https://pubmed.ncbi.nlm.nih.gov/42491662/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,42029640,Novel Perspectives on &lt;i&gt;ATP8A2&lt;/i&gt; Regulation: Evidence for Parental Imprinting and Chimeric Transcript Formation.,2026,10.3390/epigenomes10020026,https://pubmed.ncbi.nlm.nih.gov/42029640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,42486854,Loss of Atp8a2 drives neurodegeneration through the dysregulation of spatiotemporal phosphatidylserine externalization in mature neurons.,2026,10.1038/s41419-026-09097-y,https://pubmed.ncbi.nlm.nih.gov/42486854/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,41919976,Early-Onset Hyperkinetic Movement Disorders Define the Most Severe Presentation of the ATP8A2-Related Phenotypic Spectrum.,2026,10.1002/jdn.70119,https://pubmed.ncbi.nlm.nih.gov/41919976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,41769375,A decrease in Atp8a2 expression in Purkinje cells mediated acrylamide-induced cerebellar pathology in rats.,2026,10.1007/s43188-025-00322-y,https://pubmed.ncbi.nlm.nih.gov/41769375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,42879457,Genome-Wide DNA methylation profiling of tissue-plasma pairs identifies Novel cfDNA biomarkers for the diagnosis of gastric cancer.,2026,10.1371/journal.pgen.1012322,https://pubmed.ncbi.nlm.nih.gov/42879457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,39662833,Structural and functional properties of the N- and C-terminal segments of the P4-ATPase phospholipid flippase ATP8A2.,2025,10.1016/j.jbc.2024.108065,https://pubmed.ncbi.nlm.nih.gov/39662833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,39931767,"Reevaluation of the Impact of the Novel Likely Pathogenic Variant c.1286_1288delAGA in the ATP8A2 Gene: A 7-Year Follow-Up With Clinical, Genetic, and ACMG Insights in an Iranian Family.",2025,10.1002/mgg3.70081,https://pubmed.ncbi.nlm.nih.gov/39931767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,42388363,Diagnostic Yield of Genome Sequencing in an Iranian Exome-Negative Autosomal-Recessive Intellectual Disability Cohort.,2026,10.1155/humu/4623457,https://pubmed.ncbi.nlm.nih.gov/42388363/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,40886211,Identification and validation of prognostic genes associated with mitochondrial nuclear genes in gastric cancer.,2025,10.1007/s10238-025-01844-3,https://pubmed.ncbi.nlm.nih.gov/40886211/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,39066872,A novel missense variant in the ATPase domain of ATP8A2 and review of phenotypic variability of ATP8A2-related disorders caused by missense changes.,2024,10.1007/s10048-024-00773-9,https://pubmed.ncbi.nlm.nih.gov/39066872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,39681198,ATP8A2 expression is reduced in the mPFC of offspring mice exposed to maternal immune activation and its upregulation ameliorates synapse-associated protein loss and behavioral abnormalities.,2025,10.1016/j.bbi.2024.12.018,https://pubmed.ncbi.nlm.nih.gov/39681198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,41613545,Study on the regulation mechanism of TBX5 gene and Gegen Qinlian decoction on colorectal cancer.,2025,10.3389/fonc.2025.1732015,https://pubmed.ncbi.nlm.nih.gov/41613545/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,42051465,Identification of a Novel VLDLR Variant in the First Report of CAMRQ1 From Africa: Expanding the Spectrum of Cerebellar Ataxia Syndromes.,2026,10.1155/humu/4661238,https://pubmed.ncbi.nlm.nih.gov/42051465/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,41815152,Construction and validation of a palmitoylation-related prognostic model for lung adenocarcinoma based on integrated bioinformatics and machine learning.,2026,10.21037/tcr-2025-1389,https://pubmed.ncbi.nlm.nih.gov/41815152/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,39432785,"Substrate specificity controlled by the exit site of human P4-ATPases, revealed by de novo point mutations in neurological disorders.",2024,10.1073/pnas.2415755121,https://pubmed.ncbi.nlm.nih.gov/39432785/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,38436085,Functional and in silico analysis of ATP8A2 and other P4-ATPase variants associated with human genetic diseases.,2024,10.1242/dmm.050546,https://pubmed.ncbi.nlm.nih.gov/38436085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,38550056,"Retracted: Aberrant Methylation and Differential Expression of SLC2A1, TNS4, GAPDH, ATP8A2, and CASZ1 Are Associated with the Prognosis of Lung Adenocarcinoma.",2024,10.1155/2024/9862563,https://pubmed.ncbi.nlm.nih.gov/38550056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,38109455,"Compound Heterozygosity in Cerebellar Ataxia, Mental Retardation, and Disequilibrium Syndrome Type 4.",2023,10.2478/prilozi-2023-0051,https://pubmed.ncbi.nlm.nih.gov/38109455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,33766557,Neonatal LPS exposure reduces ATP8A2 level in the prefrontal cortex in mice via increasing IFN-γ level.,2021,10.1016/j.brainresbull.2021.03.015,https://pubmed.ncbi.nlm.nih.gov/33766557/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,38832431,A Comprehensive Prognostic Model for Colon Adenocarcinoma Depending on Nuclear-Mitochondrial-Related Genes.,2024,10.1177/15330338241258570,https://pubmed.ncbi.nlm.nih.gov/38832431/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,33029490,"Aberrant Methylation and Differential Expression of SLC2A1, TNS4, GAPDH, ATP8A2, and CASZ1 Are Associated with the Prognosis of Lung Adenocarcinoma.",2020,10.1155/2020/1807089,https://pubmed.ncbi.nlm.nih.gov/33029490/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,38859938,Genome-wide associations with longevity and reproductive traits in U.S. rangeland ewes.,2024,10.3389/fgene.2024.1398123,https://pubmed.ncbi.nlm.nih.gov/38859938/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,34760888,A Novel Mitochondrial-Related Nuclear Gene Signature Predicts Overall Survival of Lung Adenocarcinoma Patients.,2021,10.3389/fcell.2021.740487,https://pubmed.ncbi.nlm.nih.gov/34760888/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,31071093,Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.,2019,10.1371/journal.pbio.3000262,https://pubmed.ncbi.nlm.nih.gov/31071093/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,26567335,Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium.,2016,10.1074/jbc.m115.690727,https://pubmed.ncbi.nlm.nih.gov/26567335/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,33649193,Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions.,2021,10.1158/1541-7786.mcr-20-0937,https://pubmed.ncbi.nlm.nih.gov/33649193/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,22892528,"Missense mutation in the ATPase, aminophospholipid transporter protein ATP8A2 is associated with cerebellar atrophy and quadrupedal locomotion.",2013,10.1038/ejhg.2012.170,https://pubmed.ncbi.nlm.nih.gov/22892528/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8A2,ENSG00000132932,Unsafe,20683487,Disruption of the ATP8A2 gene in a patient with a t(10;13) de novo balanced translocation and a severe neurological phenotype.,2010,10.1038/ejhg.2010.126,https://pubmed.ncbi.nlm.nih.gov/20683487/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8B3,ENSG00000130270,Unsafe,39074670,"The aminophospholipid transporter, ATP8B3, as a potential biomarker and target for enhancing the therapeutic effect of PD-L1 blockade in colon adenocarcinoma.",2024,10.1016/j.ygeno.2024.110907,https://pubmed.ncbi.nlm.nih.gov/39074670/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8B3,ENSG00000130270,Unsafe,40187068,Novel genetic associations with childhood adipocytokines in Indian adolescents.,2025,10.1016/j.cyto.2025.156935,https://pubmed.ncbi.nlm.nih.gov/40187068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8B3,ENSG00000130270,Unsafe,40841581,Early lipid genetics: identification of common and rare genetic variants for lipid traits in Indian adolescents.,2025,10.1038/s10038-025-01388-0,https://pubmed.ncbi.nlm.nih.gov/40841581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8B3,ENSG00000130270,Unsafe,40550052,A Golgi apparatus-related signature for predicting prognosis and evaluating the tumor immune microenvironment of uveal melanoma.,2025,10.1097/md.0000000000042909,https://pubmed.ncbi.nlm.nih.gov/40550052/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8B3,ENSG00000130270,Unsafe,37835423,Genome-Wide Association Study Identifies Novel Candidate Variants Associated with Postoperative Nausea and Vomiting.,2023,10.3390/cancers15194729,https://pubmed.ncbi.nlm.nih.gov/37835423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8B3,ENSG00000130270,Unsafe,38093298,Identification and validation of eight lysosomes-related genes signatures and correlation with immune cell infiltration in lung adenocarcinoma.,2023,10.1186/s12935-023-03149-5,https://pubmed.ncbi.nlm.nih.gov/38093298/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8B3,ENSG00000130270,Unsafe,37532906,Comprehensive analysis of resistance mechanisms to EGFR-TKIs and establishment and validation of prognostic model.,2023,10.1007/s00432-023-05129-8,https://pubmed.ncbi.nlm.nih.gov/37532906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8B3,ENSG00000130270,Unsafe,37932309,Combined in vitro/in vivo genome-wide CRISPR screens in triple negative breast cancer identify cancer stemness regulators in paclitaxel resistance.,2023,10.1038/s41389-023-00497-9,https://pubmed.ncbi.nlm.nih.gov/37932309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8B3,ENSG00000130270,Unsafe,31333723,Analysis of Long Non-Coding RNA and mRNA Expression Profiling in Immature and Mature Bovine (Bos taurus) Testes.,2019,10.3389/fgene.2019.00646,https://pubmed.ncbi.nlm.nih.gov/31333723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8B3,ENSG00000130270,Unsafe,30018401,Proteomic Analysis and Functional Characterization of P4-ATPase Phospholipid Flippases from Murine Tissues.,2018,10.1038/s41598-018-29108-z,https://pubmed.ncbi.nlm.nih.gov/30018401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8B3,ENSG00000130270,Unsafe,31708974,Maternal Intake of n-3 Polyunsaturated Fatty Acids During Pregnancy Is Associated With Differential Methylation Profiles in Cord Blood White Cells.,2019,10.3389/fgene.2019.01050,https://pubmed.ncbi.nlm.nih.gov/31708974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8B3,ENSG00000130270,Unsafe,34496458,"Genomic landscape of mitochondrial DNA insertions in 23 bat genomes: characteristics, loci, phylogeny, and polymorphism.",2022,10.1111/1749-4877.12582,https://pubmed.ncbi.nlm.nih.gov/34496458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8B3,ENSG00000130270,Unsafe,34862210,Validation of Genetic Markers Associated with Survival in Colorectal Cancer Patients Treated with Oxaliplatin-Based Chemotherapy.,2022,10.1158/1055-9965.epi-21-0814,https://pubmed.ncbi.nlm.nih.gov/34862210/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8B3,ENSG00000130270,Unsafe,19017724,Expression of Atp8b3 in murine testis and its characterization as a testis specific P-type ATPase.,2009,10.1530/rep-08-0048,https://pubmed.ncbi.nlm.nih.gov/19017724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8B3,ENSG00000130270,Unsafe,28100167,Conserved gene expression in sperm reservoirs between birds and mammals in response to mating.,2017,10.1186/s12864-017-3488-x,https://pubmed.ncbi.nlm.nih.gov/28100167/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8B3,ENSG00000130270,Unsafe,20947505,Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases.,2010,10.1074/jbc.m110.139006,https://pubmed.ncbi.nlm.nih.gov/20947505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATP8B3,ENSG00000130270,Unsafe,12880872,"FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body.",2003,10.1016/s1388-1981(03)00107-0,https://pubmed.ncbi.nlm.nih.gov/12880872/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,42918796,Attractin-like protein 1 is an essential partner of MC4R to regulate body weight.,2026,10.1038/s41467-026-77897-z,https://pubmed.ncbi.nlm.nih.gov/42918796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,39562555,Large-scale single-nuclei profiling identifies role for ATRNL1 in atrial fibrillation.,2024,10.1038/s41467-024-54296-w,https://pubmed.ncbi.nlm.nih.gov/39562555/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,42061003,A predictive insight into the ATRNL1-mediated ceRNA network driving abdominal aortic aneurysm progression via VSMC phenotypic switching.,2026,10.1016/j.bbrc.2026.153817,https://pubmed.ncbi.nlm.nih.gov/42061003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,41178558,The E3 ubiquitin ligase MGRN1 targets melanocortin receptors MC1R and MC4R via interactions with transmembrane adapters.,2025,10.1242/jcs.264084,https://pubmed.ncbi.nlm.nih.gov/41178558/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,38158696,Transcriptional factor CCAAT enhancer binding protein beta inhibits epithelial-mesenchymal transition in cervical cancer via regulating attractin-like 1.,2023,10.14715/cmb/2023.69.13.1,https://pubmed.ncbi.nlm.nih.gov/38158696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,39329089,Identification of ATRNL1 and WNT9A as novel key genes and drug candidates in hypertrophic cardiomyopathy: integrative bioinformatics and experimental validation.,2024,10.3389/fmolb.2024.1458434,https://pubmed.ncbi.nlm.nih.gov/39329089/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,42256164,"Putative Genomic Signatures of Local Adaptation in Five Local Indonesian Sheep Reveal Selection on Immunity, Reproduction, and Production Traits.",2026,10.1002/ece3.73665,https://pubmed.ncbi.nlm.nih.gov/42256164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,40184718,The fusion characteristics of RET fusion in pan-cancer among the Chinese population: A comprehensive genomic analysis.,2025,10.1016/j.tranon.2025.102384,https://pubmed.ncbi.nlm.nih.gov/40184718/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,40066352,Comprehensive bioinformatics analysis of hub genes in ischemic heart failure and atrial fibrillation.,2025,10.3389/fcvm.2025.1499065,https://pubmed.ncbi.nlm.nih.gov/40066352/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,40678382,Genome-wide association and functional annotation analyses reveal candidate genes and pathways associated with various ewe longevity indicators in U.S. Katahdin sheep.,2025,10.3389/fgene.2025.1600587,https://pubmed.ncbi.nlm.nih.gov/40678382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,38533040,Comprehensive single-cell analysis reveals heterogeneity of fibroblast subpopulations in ovarian cancer tissue microenvironment.,2024,10.1016/j.heliyon.2024.e27873,https://pubmed.ncbi.nlm.nih.gov/38533040/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,40023986,Embryonic temperature influences transcriptomic and methylation profiles in the liver of juvenile largemouth bass.,2025,10.1016/j.jtherbio.2025.104073,https://pubmed.ncbi.nlm.nih.gov/40023986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,35502705,Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice.,2022,10.1242/dmm.049484,https://pubmed.ncbi.nlm.nih.gov/35502705/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,30018746,Circular RNA CpG island hypermethylation-associated silencing in human cancer.,2018,10.18632/oncotarget.25673,https://pubmed.ncbi.nlm.nih.gov/30018746/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,32857815,Whole genome sequencing analysis of high confidence variants of B-cell lymphoma in Canis familiaris.,2020,10.1371/journal.pone.0238183,https://pubmed.ncbi.nlm.nih.gov/32857815/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,33633287,Exploring the genetic architecture of feed efficiency traits in chickens.,2021,10.1038/s41598-021-84125-9,https://pubmed.ncbi.nlm.nih.gov/33633287/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,38590442,Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes.,2023,10.1155/2023/8883199,https://pubmed.ncbi.nlm.nih.gov/38590442/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,35504053,CircATRNL1 increases acid-sensing ion channel 1 to advance epithelial-mesenchymal transition in endometriosis by binding to microRNA-103a-3p.,2022,10.1016/j.repbio.2022.100643,https://pubmed.ncbi.nlm.nih.gov/35504053/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,36553445,Genomic Analysis of Gastrointestinal Parasite Resistance in Akkaraman Sheep.,2022,10.3390/genes13122177,https://pubmed.ncbi.nlm.nih.gov/36553445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ATRNL1,ENSG00000107518,Unsafe,37036095,"Long-term Survival, Quality of Life, and Molecular Features of the Patients With Solid Pseudopapillary Neoplasm of the Pancreas: A Retrospective Study of 454 Cases.",2023,10.1097/sla.0000000000005842,https://pubmed.ncbi.nlm.nih.gov/37036095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AUNIP,ENSG00000127423,Unsafe,42096614,Targeting TROP2 and Exploiting AUNIP as a Determinant of ADC Cytotoxicity and Chemosensitivity in HNSCC and ESCA Cancers.,2026,10.1002/mc.70115,https://pubmed.ncbi.nlm.nih.gov/42096614/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AUNIP,ENSG00000127423,Unsafe,40386627,AUNIP was a candidate marker for prognosis and immunology in pan-cancer.,2025,10.1007/s13205-025-04294-6,https://pubmed.ncbi.nlm.nih.gov/40386627/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AUNIP,ENSG00000127423,Unsafe,41721176,A novel aurora kinase molecular glue-based degrader sp-2-067 inhibits prostate cancer cell growth and alters immune profile.,2026,10.1007/s10637-026-01603-5,https://pubmed.ncbi.nlm.nih.gov/41721176/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AUNIP,ENSG00000127423,Unsafe,41585903,Exploratory research on therapeutic agents combined with early diagnostic biomarkers for colorectal cancer.,2025,10.3389/fphar.2025.1723072,https://pubmed.ncbi.nlm.nih.gov/41585903/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AUNIP,ENSG00000127423,Unsafe,39148731,Integrated bioinformatics analysis of nucleotide metabolism based molecular subtyping and biomarkers in lung adenocarcinoma.,2024,10.3389/fimmu.2024.1430171,https://pubmed.ncbi.nlm.nih.gov/39148731/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AUNIP,ENSG00000127423,Unsafe,37348876,Large-scale rare variant burden testing in Parkinson's disease.,2023,10.1093/brain/awad214,https://pubmed.ncbi.nlm.nih.gov/37348876/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AUNIP,ENSG00000127423,Unsafe,33363020,AUNIP Expression Is Correlated With Immune Infiltration and Is a Candidate Diagnostic and Prognostic Biomarker for Hepatocellular Carcinoma and Lung Adenocarcinoma.,2020,10.3389/fonc.2020.590006,https://pubmed.ncbi.nlm.nih.gov/33363020/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AUNIP,ENSG00000127423,Unsafe,31409573,Identification of AUNIP as a candidate diagnostic and prognostic biomarker for oral squamous cell carcinoma.,2019,10.1016/j.ebiom.2019.08.013,https://pubmed.ncbi.nlm.nih.gov/31409573/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AUNIP,ENSG00000127423,Unsafe,29042561,AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway.,2017,10.1038/s41467-017-01151-w,https://pubmed.ncbi.nlm.nih.gov/29042561/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AUNIP,ENSG00000127423,Unsafe,35846349,Identification of Potential Antigens for Developing mRNA Vaccine for Immunologically Cold Mesothelioma.,2022,10.3389/fcell.2022.879278,https://pubmed.ncbi.nlm.nih.gov/35846349/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AUNIP,ENSG00000127423,Unsafe,36523322,Prognostic biomarkers of pancreatic cancer identified based on a competing endogenous RNA regulatory network.,2022,10.21037/tcr-22-709,https://pubmed.ncbi.nlm.nih.gov/36523322/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AUNIP,ENSG00000127423,Unsafe,35559013,Homologous Recombination Related Signatures Predict Prognosis and Immunotherapy Response in Metastatic Urothelial Carcinoma.,2022,10.3389/fgene.2022.875128,https://pubmed.ncbi.nlm.nih.gov/35559013/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AUNIP,ENSG00000127423,Unsafe,24413707,A three-stage genome-wide association study combining multilocus test and gene expression analysis for young-onset hypertension in Taiwan Han Chinese.,2014,10.1093/ajh/hpt239,https://pubmed.ncbi.nlm.nih.gov/24413707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42289849,A peripheral blood-based approach involving vimentin along with AURKA enabled efficient tracking of elusive Oct4/Sox2-expressing disseminated breast cancer stem cells.,2026,10.1042/bsr20253828,https://pubmed.ncbi.nlm.nih.gov/42289849/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42436338,AURKA regulates LGR5 in response to Helicobacter Pylori infection by modulating its deubiquitination.,2026,10.1038/s41418-026-01810-w,https://pubmed.ncbi.nlm.nih.gov/42436338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42098768,Aurora A kinase activation contributes to the fibrotic phenotype in systemic sclerosis through primary cilia shortening.,2026,10.1186/s13075-026-03826-6,https://pubmed.ncbi.nlm.nih.gov/42098768/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42838963,α7 integrin co-regulates chromatin accessibility and gene expression in HPV-negative head and neck cancer.,2026,10.1038/s41392-026-02995-9,https://pubmed.ncbi.nlm.nih.gov/42838963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,41908244,ncRNA-Mediated Upregulation of AURKA Promotes Hepatocellular Carcinoma Progression and Alters the Immune Microenvironment.,2026,10.1177/11779322261435461,https://pubmed.ncbi.nlm.nih.gov/41908244/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,41896238,Aurka-Bhlhe41 axis prevents premature aging-like microglial dysfunction and promotes remyelination.,2026,10.1038/s41467-026-71014-w,https://pubmed.ncbi.nlm.nih.gov/41896238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42755650,Peptides whose levels change during the attack period in episodic migraine: NETRIN-1 and amylin.,2026,10.3389/fneur.2026.1932356,https://pubmed.ncbi.nlm.nih.gov/42755650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,41475344,Splice-switching ASOs targeting the AURKA 5' UTR collapse an SRSF1-AURKA-MYC oncogenic circuit in pancreatic cancer.,2026,10.1016/j.molcel.2025.12.004,https://pubmed.ncbi.nlm.nih.gov/41475344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42678049,Inhibition of Aurora Kinase A Prevents Malignant Transformation in Oral Leukoplakia.,2026,10.1111/jop.70177,https://pubmed.ncbi.nlm.nih.gov/42678049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42714638,DOT1L-mediated H3K79me3 of ITCH promotes AURKA ubiquitination to suppress ECM degradation in osteoarthritis.,2026,10.1007/s00438-026-02514-z,https://pubmed.ncbi.nlm.nih.gov/42714638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42741940,Hemiplegic migraine: genetics and pathophysiology.,2026,10.1172/jci208001,https://pubmed.ncbi.nlm.nih.gov/42741940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,41512825,Finding an Achilles' heel of cancer cells: Exonized Alu elements in AURKA.,2026,10.1016/j.molcel.2025.12.011,https://pubmed.ncbi.nlm.nih.gov/41512825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42031711,AURKA/PHB2 signaling drives acquired resistance to KRAS &lt;sup&gt;G12C&lt;/sup&gt; inhibitors in KRAS &lt;sup&gt;G12C&lt;/sup&gt;-mutant NSCLC.,2026,10.1038/s41420-026-03080-4,https://pubmed.ncbi.nlm.nih.gov/42031711/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,41576363,"NN-01-195, a Novel Conjugate of HSP90 and AURKA Inhibitors, Effectively Targets Solid Tumors.",2026,10.1158/1535-7163.mct-25-0857,https://pubmed.ncbi.nlm.nih.gov/41576363/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42853499,High Expression of Aurora Kinase A (AURKA) is Associated with Aggressive Tumor Biology and Therapeutic Response in ER+/HER2- Breast Cancer.,2026,10.1245/s10434-026-20599-z,https://pubmed.ncbi.nlm.nih.gov/42853499/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42511467,Targeting CDK2 and AURKA with Cerevisterol from &lt;i&gt;Ganoderma lucidum&lt;/i&gt; to Sensitize Colorectal Cancer to Chemotherapy.,2026,10.3390/ijms27146120,https://pubmed.ncbi.nlm.nih.gov/42511467/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42717326,Retinal optical coherence tomography angiography findings in the new- onset migraine patients: a prospective case-control study.,2026,10.1186/s12886-026-05195-9,https://pubmed.ncbi.nlm.nih.gov/42717326/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,41515655,The Role of Aurora Kinase A in HBV-Associated Hepatocellular Carcinomas: A Molecular and Immunohistochemical Study.,2026,10.3390/diagnostics16010160,https://pubmed.ncbi.nlm.nih.gov/41515655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,41545643,Identification of hub genes and construction of a survival prediction model for patients with nasopharyngeal carcinoma.,2026,10.1038/s41598-026-36395-4,https://pubmed.ncbi.nlm.nih.gov/41545643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42643961,Machine learning-based identification of hub genes and prognostic biomarkers in prostate cancer.,2026,10.3389/fgene.2026.1877595,https://pubmed.ncbi.nlm.nih.gov/42643961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,41592279,Targeting Aurora kinase A to prevent GVHD and relapse after myeloablative allogeneic hematopoietic cell transplantation.,2026,10.1182/bloodadvances.2025017360,https://pubmed.ncbi.nlm.nih.gov/41592279/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42757309,Dipyridamole as a Perioperatively Safe Aurora Kinase A Inhibitor for Neoadjuvant Therapy in Esophageal Squamous Cell Carcinoma.,2026,10.2147/ott.s620767,https://pubmed.ncbi.nlm.nih.gov/42757309/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42111498,A Cuproptosis-Glycolysis Signature Predicts Prognosis and Highlights AURKA as a Therapeutic Target in ccRCC.,2026,10.1155/humu/6111105,https://pubmed.ncbi.nlm.nih.gov/42111498/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42407398,"Precision targeting in biliary tract cancer therapy: A geographical, target, and efficacy analysis of clinical trials.",2026,10.1016/j.bbcan.2026.189643,https://pubmed.ncbi.nlm.nih.gov/42407398/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42076055,"Mitotic Machinery Dysregulation in Lung Cancer: Biological Roles, Therapeutic Targeting, and Combination Strategies.",2026,10.3390/pharmaceutics18040402,https://pubmed.ncbi.nlm.nih.gov/42076055/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42224282,Multi-omics and pan-cancer analysis revealed common molecular signatures to disclose multitargeted anticancer agents through network pharmacology approach.,2026,10.1371/journal.pone.0350614,https://pubmed.ncbi.nlm.nih.gov/42224282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,41409428,Aurora Kinases in Ocular Malignancies: Functional Significance and Potential Implications.,2026,10.1159/000549336,https://pubmed.ncbi.nlm.nih.gov/41409428/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42034602,TCHP drives hepatocarcinogenesis through LLPS-mediated AURKA condensation and enables synergistic therapy.,2026,10.1038/s41419-026-08681-6,https://pubmed.ncbi.nlm.nih.gov/42034602/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42749415,Integrative multi-transcriptomics and network pharmacology reveal natural therapeutics as anti-cancer agents targeting AURKA for ovarian cancer treatment.,2026,10.1016/j.jgeb.2026.100745,https://pubmed.ncbi.nlm.nih.gov/42749415/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,40995659,AURKA Enhances Antitumor Immunity by Activating CD4+ T Cell Proliferation in Colorectal Cancer.,2025,10.1080/07357907.2025.2559403,https://pubmed.ncbi.nlm.nih.gov/40995659/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,41528535,Surgical outcomes after neoadjuvant avelumab with or without chemotherapy for Muscle-Invasive bladder cancer: a Post-Hoc analysis of the aura trial (Oncodistinct-004).,2026,10.1007/s00345-026-06192-9,https://pubmed.ncbi.nlm.nih.gov/41528535/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42665663,Universal pipeline for high-resolution GPCR structure determination.,2026,10.1038/s41594-026-01869-6,https://pubmed.ncbi.nlm.nih.gov/42665663/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,40869479,The Dynamic Field of Perioperative Treatment for Localized Muscle-Invasive Bladder Cancer: A Review of the Current Research Landscape.,2025,10.3390/jcm14165653,https://pubmed.ncbi.nlm.nih.gov/40869479/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,42581340,Migraine immune cell gene targets and their relationship to psychiatric disorders.,2026,10.1186/s10194-026-02465-1,https://pubmed.ncbi.nlm.nih.gov/42581340/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKA,ENSG00000087586,Unsafe,39209449,Adenovirus vaccine targeting kinases induces potent antitumor immunity in solid tumors.,2024,10.1136/jitc-2024-009869,https://pubmed.ncbi.nlm.nih.gov/39209449/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,42042038,Dysregulation of Aurora Kinases and &lt;i&gt;AURKAIP1&lt;/i&gt; Promoter Methylation as Potential Peripheral Diagnostic Biomarkers in Acute Myeloid Leukemia.,2026,10.3390/cimb48040378,https://pubmed.ncbi.nlm.nih.gov/42042038/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,39895780,AURKC Promotes Clear Cell Renal Cell Carcinoma Proliferation Through Upregulation of ERp57.,2025,10.7150/jca.103134,https://pubmed.ncbi.nlm.nih.gov/39895780/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,40481349,The expression and prognosis for Aurora kinases in human non-small cell lung cancer.,2025,10.1007/s12672-025-02878-5,https://pubmed.ncbi.nlm.nih.gov/40481349/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,42152106,Identification of a different DNA methylation pattern for pain related genes in children with intellectual disability: a cross-sectional study.,2026,10.1186/s13052-026-02274-x,https://pubmed.ncbi.nlm.nih.gov/42152106/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,41941847,"Molecular mechanisms of DBDPE-induced spermatogenic disorder: A network toxicology, machine learning, and in vivo experimental validation.",2026,10.1016/j.envint.2026.110220,https://pubmed.ncbi.nlm.nih.gov/41941847/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,39081293,Spatio-temporal requirements of Aurora kinase A in mouse oocyte meiotic spindle building.,2024,10.1016/j.isci.2024.110451,https://pubmed.ncbi.nlm.nih.gov/39081293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,39133293,Successful intracytoplasmic sperm injection in a macrozoospermia case with novel compound heterozygous aurora kinase C (AURKC) mutations.,2024,10.1007/s00404-024-07619-7,https://pubmed.ncbi.nlm.nih.gov/39133293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,40533769,Aurora kinases signaling in cancer: from molecular perception to targeted therapies.,2025,10.1186/s12943-025-02353-3,https://pubmed.ncbi.nlm.nih.gov/40533769/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,39923999,De-regulation of aurora kinases by oncogenic HPV; implications in cancer development and treatment.,2025,10.1016/j.tvr.2025.200314,https://pubmed.ncbi.nlm.nih.gov/39923999/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,39841288,Whole exome sequencing reveals ABCD1 variant as a potential contributor to male infertility.,2025,10.1007/s11033-025-10234-7,https://pubmed.ncbi.nlm.nih.gov/39841288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,37833923,Comprehensive Analysis of the Transcriptome-Wide m6A Methylome in Shaziling Pig Testicular Development.,2023,10.3390/ijms241914475,https://pubmed.ncbi.nlm.nih.gov/37833923/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,39386021,Genetic interaction mapping of Aurora protein kinases in mouse oocytes.,2024,10.3389/fcell.2024.1455280,https://pubmed.ncbi.nlm.nih.gov/39386021/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,37700958,A Case of Severe Teratozoospermia and Infertility Due to Homozygous Mutation c.144delC in the AURKC Gene.,2023,10.7759/cureus.43376,https://pubmed.ncbi.nlm.nih.gov/37700958/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,38764730,Comprehensive genomic profiling of pediatric peritoneal mesothelioma: case report with a literature review.,2024,10.1093/jscr/rjae324,https://pubmed.ncbi.nlm.nih.gov/38764730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,35017390,"From azoospermia to macrozoospermia, a phenotypic continuum due to mutations in the ZMYND15 gene.",2022,10.4103/aja202194,https://pubmed.ncbi.nlm.nih.gov/35017390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,38061432,Transcriptome and proteome analyses reveal the mechanisms involved in polystyrene nanoplastics disrupt spermatogenesis in mice.,2024,10.1016/j.envpol.2023.123086,https://pubmed.ncbi.nlm.nih.gov/38061432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,34772938,Mammalian SWI/SNF chromatin remodeler is essential for reductional meiosis in males.,2021,10.1038/s41467-021-26828-1,https://pubmed.ncbi.nlm.nih.gov/34772938/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,34573302,"Evolution, Expression and Meiotic Behavior of Genes Involved in Chromosome Segregation of Monotremes.",2021,10.3390/genes12091320,https://pubmed.ncbi.nlm.nih.gov/34573302/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,34461108,The oncogenic role of meiosis-specific Aurora kinase C in mitotic cells.,2021,10.1016/j.yexcr.2021.112803,https://pubmed.ncbi.nlm.nih.gov/34461108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,38764682,"Preclinical Evaluation of JAB-2485, a Potent AURKA Inhibitor with High Selectivity and Favorable Pharmacokinetic Properties.",2024,10.1021/acsomega.4c01752,https://pubmed.ncbi.nlm.nih.gov/38764682/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,33915740,Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for Cancer.,2021,10.3390/molecules26071981,https://pubmed.ncbi.nlm.nih.gov/33915740/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,34866894,AURKB as a Promising Prognostic Biomarker in Hepatocellular Carcinoma.,2021,10.1177/11769343211057589,https://pubmed.ncbi.nlm.nih.gov/34866894/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,39065690,Discovery of 1H-benzo[d]imidazole-(halogenated) Benzylidenebenzohydrazide Hybrids as Potential Multi-Kinase Inhibitors.,2024,10.3390/ph17070839,https://pubmed.ncbi.nlm.nih.gov/39065690/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,33965371,Exposure to the bromodomain inhibitor N-methyl pyrrolidone blocks spermatogenesis in a hormonal and non-hormonal fashion.,2021,10.1016/j.taap.2021.115568,https://pubmed.ncbi.nlm.nih.gov/33965371/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,33901174,Aurora kinase A is essential for meiosis in mouse oocytes.,2021,10.1371/journal.pgen.1009327,https://pubmed.ncbi.nlm.nih.gov/33901174/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,29050234,A small-molecule inhibitor targeting the AURKC-IκBα interaction decreases transformed growth of MDA-MB-231 breast cancer cells.,2017,10.18632/oncotarget.18883,https://pubmed.ncbi.nlm.nih.gov/29050234/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,33257688,BRDT promotes ovarian cancer cell growth.,2020,10.1038/s41419-020-03225-y,https://pubmed.ncbi.nlm.nih.gov/33257688/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,25994570,"Transcriptome analysis of the cancer/testis genes, DAZ1, AURKC, and TEX101, in breast tumors and six breast cancer cell lines.",2015,10.1007/s13277-015-3546-4,https://pubmed.ncbi.nlm.nih.gov/25994570/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,26347867,Functions of Aurora kinase C in meiosis and cancer.,2015,10.3389/fcell.2015.00050,https://pubmed.ncbi.nlm.nih.gov/26347867/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,35741659,Exploration of the Common Gene Characteristics and Molecular Mechanism of Parkinson's Disease and Crohn's Disease from Transcriptome Data.,2022,10.3390/brainsci12060774,https://pubmed.ncbi.nlm.nih.gov/35741659/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,24632603,The aurora kinases in cell cycle and leukemia.,2015,10.1038/onc.2014.14,https://pubmed.ncbi.nlm.nih.gov/24632603/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,28369513,Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy.,2017,10.1093/molehr/gax018,https://pubmed.ncbi.nlm.nih.gov/28369513/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AURKC,ENSG00000105146,Unsafe,15670791,Cloning and characterization of a novel human Aurora C splicing variant.,2005,10.1016/j.bbrc.2004.12.168,https://pubmed.ncbi.nlm.nih.gov/15670791/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AXDND1,ENSG00000162779,Unsafe,38997255,AXDND1 is required to balance spermatogonial commitment and for sperm tail formation in mice and humans.,2024,10.1038/s41419-024-06874-5,https://pubmed.ncbi.nlm.nih.gov/38997255/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AXDND1,ENSG00000162779,Unsafe,40457935,A novel frameshift variant in AXDND1 may cause multiple morphological abnormalities of the sperm flagella in a consanguineous Pakistani family.,2025,10.4103/aja202538,https://pubmed.ncbi.nlm.nih.gov/40457935/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AXDND1,ENSG00000162779,Unsafe,34759295,"AXDND1, a novel testis-enriched gene, is required for spermiogenesis and male fertility.",2021,10.1038/s41420-021-00738-z,https://pubmed.ncbi.nlm.nih.gov/34759295/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AXDND1,ENSG00000162779,Unsafe,41395597,Identification of a signature gene set for oxaliplatin sensitivity prediction in colorectal cancer.,2025,10.3389/fonc.2025.1701328,https://pubmed.ncbi.nlm.nih.gov/41395597/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AXDND1,ENSG00000162779,Unsafe,35386379,Loss of Axdnd1 causes sterility due to impaired spermatid differentiation in mice.,2022,10.1002/rmb2.12452,https://pubmed.ncbi.nlm.nih.gov/35386379/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AXDND1,ENSG00000162779,Unsafe,37386009,Classification and deep-learning-based prediction of Alzheimer disease subtypes by using genomic data.,2023,10.1038/s41398-023-02531-1,https://pubmed.ncbi.nlm.nih.gov/37386009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AXDND1,ENSG00000162779,Unsafe,39357512,Next-Generation Integrated Sequencing Identifies Poor Prognostic Factors in Patients with MYD88-Mutated Chronic Lymphocytic Leukemia in Taiwan.,2025,10.1159/000541709,https://pubmed.ncbi.nlm.nih.gov/39357512/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,42749715,NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates.,2026,10.1038/s41467-026-76769-w,https://pubmed.ncbi.nlm.nih.gov/42749715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,42737828,Nucleosome Assembly Protein 1 in Dinoflagellate Cells Without Architectural Nucleosomes.,2026,10.3390/ijms27177931,https://pubmed.ncbi.nlm.nih.gov/42737828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,41876515,Machine learning-based predictive models and subtypes patterns in peripheral blood of schizophrenia based on a machine learning computational framework.,2026,10.1038/s41537-026-00744-z,https://pubmed.ncbi.nlm.nih.gov/41876515/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,39276928,TBK1 adaptor AZI2/NAP1 regulates NDP52-driven mitochondrial autophagy.,2024,10.1016/j.jbc.2024.107775,https://pubmed.ncbi.nlm.nih.gov/39276928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,41171761,Phospho-proteome profiling in human neurons reveals targets of TBK1 in ALS/FTD-associated autophagy networks.,2025,10.1016/j.celrep.2025.116494,https://pubmed.ncbi.nlm.nih.gov/41171761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,41675379,Single-cell analyses reveal impaired type B spermatogonia differentiation and meiotic entry in C-Nap1-null testes.,2025,10.1002/qub2.71,https://pubmed.ncbi.nlm.nih.gov/41675379/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,42601952,Exploratory multi-omics analysis suggests context-dependent immune responses to vitamin D&lt;sub&gt;3&lt;/sub&gt; supplementation in PBMCs of multiple sclerosis patients.,2026,10.3389/fimmu.2026.1845005,https://pubmed.ncbi.nlm.nih.gov/42601952/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,39562788,TBK1-associated adapters TANK and AZI2 protect mice against TNF-induced cell death and severe autoinflammatory diseases.,2024,10.1038/s41467-024-54399-4,https://pubmed.ncbi.nlm.nih.gov/39562788/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,37733921,AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer.,2024,10.1080/15548627.2023.2259775,https://pubmed.ncbi.nlm.nih.gov/37733921/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,42404645,Dynamic networks of intrinsically disordered regions in nuclear proteins.,2026,10.2142/biophysico.bppb-v23.0020,https://pubmed.ncbi.nlm.nih.gov/42404645/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,42280006,Comparative Evaluation of Synthetic Zeolites for Radium and Barium Removal from Contaminated Water: From Ideal Solutions to Real Mine Water Matrix.,2026,10.3390/ma19112353,https://pubmed.ncbi.nlm.nih.gov/42280006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,42103228,Structural basis for HIV-1 Rev recognition by the histone chaperone human Nap1.,2026,10.1016/j.jbc.2026.113120,https://pubmed.ncbi.nlm.nih.gov/42103228/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,41626871,"Large-Scaled Proteomics Analysis for Glaucoma: Integrated Genetics, Multi-Omics, UK Biobank and Therapeutic Analysis.",2026,10.1167/iovs.67.2.4,https://pubmed.ncbi.nlm.nih.gov/41626871/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,39645055,Nap1 is essential for eupyrene spermatogenesis and migration in Plutella xylostella.,2025,10.1016/j.ibmb.2024.104245,https://pubmed.ncbi.nlm.nih.gov/39645055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,40581253,The nucleoporin CPR5 and histone chaperone NAP1 form a complex to negatively modulate plant immunity.,2026,10.1016/j.jgg.2025.06.002,https://pubmed.ncbi.nlm.nih.gov/40581253/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,42046315,Histone Density and Dynamics Shape Mitotic Chromatid Architecture in Xenopus Egg Extracts.,2026,10.1111/gtc.70113,https://pubmed.ncbi.nlm.nih.gov/42046315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,41309605,Roles of histone chaperone Nap1 and histone acetylation in regulating phase-separation of nucleosome arrays.,2025,10.1038/s41467-025-65701-3,https://pubmed.ncbi.nlm.nih.gov/41309605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,42036718,GCN5-mediated histone H3 acetylation orchestrates gene expression and plant development via H2A.Z.,2026,10.1111/nph.71212,https://pubmed.ncbi.nlm.nih.gov/42036718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,41906788,Phenotypic and genetic resistance to Septoria blotch disease in European wheat varieties.,2026,10.1002/tpg2.70237,https://pubmed.ncbi.nlm.nih.gov/41906788/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,41736444,Histone Nuclear Import and Beyond: Multifunctional Roles of Importins.,2026,10.1002/bies.70119,https://pubmed.ncbi.nlm.nih.gov/41736444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,38367203,The chromatin remodeler ERCC6 and the histone chaperone NAP1 are involved in apurinic/apyrimidinic endonuclease-mediated DNA repair.,2024,10.1093/plcell/koae052,https://pubmed.ncbi.nlm.nih.gov/38367203/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,37239401,Genome-Wide Identification and Functional Analysis of NAP1 in Triticum aestivum.,2023,10.3390/genes14051041,https://pubmed.ncbi.nlm.nih.gov/37239401/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,38524230,The Strain and the Clinical Outcome of Clostridioides difficile Infection: A Meta-analysis.,2024,10.1093/ofid/ofae085,https://pubmed.ncbi.nlm.nih.gov/38524230/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,35887015,"Nucleosome Assembly Protein 1, Nap1, Is Required for the Growth, Development, and Pathogenicity of Magnaporthe oryzae.",2022,10.3390/ijms23147662,https://pubmed.ncbi.nlm.nih.gov/35887015/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,40047067,Adaptor-Mediated Trafficking of Tank Binding Kinase 1 During Diverse Cellular Processes.,2025,10.1111/tra.70000,https://pubmed.ncbi.nlm.nih.gov/40047067/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,40732025,Minimum Inhibitory Concentration Increase in &lt;i&gt;Clostridioides difficile&lt;/i&gt; Isolates from Patients with Recurrence: Results from a Retrospective Single-Centre Cohort Study.,2025,10.3390/microorganisms13071515,https://pubmed.ncbi.nlm.nih.gov/40732025/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,32580962,FIP200 Suppresses Immune Checkpoint Therapy Responses in Breast Cancers by Limiting AZI2/TBK1/IRF Signaling Independent of Its Canonical Autophagy Function.,2020,10.1158/0008-5472.can-20-0519,https://pubmed.ncbi.nlm.nih.gov/32580962/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,34076483,NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation.,2021,10.1128/jvi.00836-21,https://pubmed.ncbi.nlm.nih.gov/34076483/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,30420664,TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation.,2018,10.1038/s41556-018-0229-6,https://pubmed.ncbi.nlm.nih.gov/30420664/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,28125650,Development of a Novel Vaccine Containing Binary Toxin for the Prevention of Clostridium difficile Disease with Enhanced Efficacy against NAP1 Strains.,2017,10.1371/journal.pone.0170640,https://pubmed.ncbi.nlm.nih.gov/28125650/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,33116952,Investigational Treatment Agents for Recurrent Clostridioides difficile Infection (rCDI).,2020,10.2147/jep.s242959,https://pubmed.ncbi.nlm.nih.gov/33116952/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,32842679,A Replicating Single-Cycle Adenovirus Vaccine Effective against Clostridium difficile.,2020,10.3390/vaccines8030470,https://pubmed.ncbi.nlm.nih.gov/32842679/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,34168208,Exoproteomic analysis of two MLST clade 2 strains of Clostridioides difficile from Latin America reveal close similarities.,2021,10.1038/s41598-021-92684-0,https://pubmed.ncbi.nlm.nih.gov/34168208/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZI2,ENSG00000163512,Unsafe,14560022,"Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling.",2003,10.1128/mcb.23.21.7780-7793.2003,https://pubmed.ncbi.nlm.nih.gov/14560022/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,40754155,A key role of polyamine metabolism in adipose tissue homeostasis that regulates obesity.,2025,10.1016/j.metabol.2025.156358,https://pubmed.ncbi.nlm.nih.gov/40754155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,38797332,AZIN2 is associated with apoptosis of germ cells in undescended testis.,2024,10.1016/j.cdev.2024.203925,https://pubmed.ncbi.nlm.nih.gov/38797332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,36671399,Antizyme Inhibitor 2-Deficient Mice Exhibit Altered Brain Polyamine Levels and Reduced Locomotor Activity.,2022,10.3390/biom13010014,https://pubmed.ncbi.nlm.nih.gov/36671399/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,40032914,Ornithine decarboxylase antizyme 2 (OAZ2) in human colon adenocarcinoma: a potent prognostic factor associated with immunity.,2025,10.1038/s41598-025-90066-4,https://pubmed.ncbi.nlm.nih.gov/40032914/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,26963840,Expression of ODC Antizyme Inhibitor 2 (AZIN2) in Human Secretory Cells and Tissues.,2016,10.1371/journal.pone.0151175,https://pubmed.ncbi.nlm.nih.gov/26963840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,30566531,New insights of polyamine metabolism in testicular physiology: A role of ornithine decarboxylase antizyme inhibitor 2 (AZIN2) in the modulation of testosterone levels and sperm motility.,2018,10.1371/journal.pone.0209202,https://pubmed.ncbi.nlm.nih.gov/30566531/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,34046926,Antizyme inhibitor 2 (AZIN2) associates with better prognosis of head and neck minor salivary gland adenoid cystic carcinoma.,2021,10.1111/apm.13158,https://pubmed.ncbi.nlm.nih.gov/34046926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,33586680,Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.,2021,10.1172/jci126299,https://pubmed.ncbi.nlm.nih.gov/33586680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,34082109,Hypoxia-induced antizyme inhibitors 2 regulates cisplatin resistance through epithelia-mesenchymal transition pathway in non-small cell lung cancer.,2021,10.1016/j.pupt.2021.102048,https://pubmed.ncbi.nlm.nih.gov/34082109/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,40095415,Altered Arginine Metabolism Affects Proliferation and Radiosensitivity of Keloids.,2025,10.1111/exd.70077,https://pubmed.ncbi.nlm.nih.gov/40095415/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,30768610,Ornithine decarboxylase antizyme inhibitor 2 (AZIN2) is a signature of secretory phenotype and independent predictor of adverse prognosis in colorectal cancer.,2019,10.1371/journal.pone.0211564,https://pubmed.ncbi.nlm.nih.gov/30768610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,36111654,Outreach dental care program for older adults using residential care or day care services in Hong Kong: A cohort study.,2023,10.1111/cdoe.12793,https://pubmed.ncbi.nlm.nih.gov/36111654/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,29584819,Loss of AZIN2 splice variant facilitates endogenous cardiac regeneration.,2018,10.1093/cvr/cvy075,https://pubmed.ncbi.nlm.nih.gov/29584819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,36035152,Analysis of the Prognostic Significance and Immune Infiltration of the Amino Acid Metabolism-Related Genes in Colon Adenocarcinoma.,2022,10.3389/fgene.2022.951461,https://pubmed.ncbi.nlm.nih.gov/36035152/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,30545799,Inhibition of AZIN2-sv induces neovascularization and improves prognosis after myocardial infarction by blocking ubiquitin-dependent talin1 degradation and activating the Akt pathway.,2019,10.1016/j.ebiom.2018.12.001,https://pubmed.ncbi.nlm.nih.gov/30545799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,33827696,Pre-implantation exogenous progesterone and pregnancy in sheep. II. Effects on fetal-placental development and nutrient transporters in late pregnancy.,2021,10.1186/s40104-021-00567-1,https://pubmed.ncbi.nlm.nih.gov/33827696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,34955765,Molecular Segmentation of the Spinal Trigeminal Nucleus in the Adult Mouse Brain.,2021,10.3389/fnana.2021.785840,https://pubmed.ncbi.nlm.nih.gov/34955765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,23874910,Antizyme inhibitor 2 hypomorphic mice. New patterns of expression in pancreas and adrenal glands suggest a role in secretory processes.,2013,10.1371/journal.pone.0069188,https://pubmed.ncbi.nlm.nih.gov/23874910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,33663606,"Pre-implantation exogenous progesterone and pregnancy in sheep: I. polyamines, nutrient transport, and progestamedins.",2021,10.1186/s40104-021-00554-6,https://pubmed.ncbi.nlm.nih.gov/33663606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,28467636,An exercise in brain genoarchitectonics: Analysis of AZIN2-Lacz expressing neuronal populations in the mouse hindbrain.,2018,10.1002/jnr.24053,https://pubmed.ncbi.nlm.nih.gov/28467636/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,19832840,Brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimer's disease.,2010,10.1111/j.1750-3639.2009.00334.x,https://pubmed.ncbi.nlm.nih.gov/19832840/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,19756694,"High expression of antizyme inhibitor 2, an activator of ornithine decarboxylase in steroidogenic cells of human gonads.",2009,10.1007/s00418-009-0636-7,https://pubmed.ncbi.nlm.nih.gov/19756694/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,19718454,Expression of antizyme inhibitor 2 in mast cells and role of polyamines as selective regulators of serotonin secretion.,2009,10.1371/journal.pone.0006858,https://pubmed.ncbi.nlm.nih.gov/19718454/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,14738999,"Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine.",2004,10.1016/j.bbagen.2003.11.006,https://pubmed.ncbi.nlm.nih.gov/14738999/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
AZIN2,ENSG00000142920,Unsafe,11587527,Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes.,2001,10.1006/bbrc.2001.5703,https://pubmed.ncbi.nlm.nih.gov/11587527/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,42715804,B3GNT5-associated glycosylation remodeling in tumor-associated macrophages supports TGF-β-related glioma progression.,2026,10.1016/j.bbagen.2026.130997,https://pubmed.ncbi.nlm.nih.gov/42715804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,40847295,Regulation of EMT-MET and chemoresistance by the Lc3Cer-synthase B3GNT5.,2025,10.1186/s12885-025-14717-5,https://pubmed.ncbi.nlm.nih.gov/40847295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,42323373,Genome-wide DNA methylation profiling during metabolic dysfunction-associated steatohepatitis-related hepatocarcinogenesis in patients in Japan and the United States.,2026,10.1038/s41598-026-57253-3,https://pubmed.ncbi.nlm.nih.gov/42323373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,39671359,Pan-cancer analysis of B3GNT5 with potential implications for cancer immunotherapy and cancer stem cell stemness.,2024,10.1371/journal.pone.0314609,https://pubmed.ncbi.nlm.nih.gov/39671359/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,39319269,B3GNT5 is a novel marker correlated with malignant phenotype and poor outcome in pancreatic cancer.,2024,10.1016/j.isci.2024.110889,https://pubmed.ncbi.nlm.nih.gov/39319269/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,40460976,CircTNFRSF19 facilitates triple negative breast cancer cell growth by regulating N6-methyladenosine modification of B3GNT5: Medical biological image simulation.,2025,10.1016/j.slast.2025.100308,https://pubmed.ncbi.nlm.nih.gov/40460976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,39981259,Exploring the relationship between sepsis and Golgi apparatus dysfunction: bioinformatics insights and diagnostic marker discovery.,2025,10.3389/fgene.2025.1483493,https://pubmed.ncbi.nlm.nih.gov/39981259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,41056334,OCIAD2 as a novel prognostic and therapeutic biomarker for pancreatic cancer: A study based on transcriptomic signature and bioinformatics analysis.,2025,10.1371/journal.pcbi.1013566,https://pubmed.ncbi.nlm.nih.gov/41056334/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,39414978,Fucosylation of glycoproteins and glycolipids: opposing roles in cholera intoxication.,2025,10.1038/s41589-024-01748-5,https://pubmed.ncbi.nlm.nih.gov/39414978/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,41581316,Utilization of machine learning algorithms for the identification of the RLN associated prognostic model and feature biomarkers of RLN-related subtypes in breast cancer.,2026,10.1016/j.tranon.2026.102684,https://pubmed.ncbi.nlm.nih.gov/41581316/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,41459856,In Silico Analysis of the Role of Estrogen Signaling in the Expression of Metabolic Genes in Breast Cancer.,2025,10.31557/apjcp.2025.26.12.4419,https://pubmed.ncbi.nlm.nih.gov/41459856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,39242706,Prostate cancer subtyping and differential methylation analysis based on the ETS family of transcription factors fusion genes.,2024,10.1038/s41598-024-71285-7,https://pubmed.ncbi.nlm.nih.gov/39242706/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,39655358,Tumor-Expressed SPPL3 Supports Innate Antitumor Immune Responses.,2025,10.1002/eji.202451129,https://pubmed.ncbi.nlm.nih.gov/39655358/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,37934565,Identification of M5c regulator-medicated methylation modification patterns for prognosis and immune microenvironment in glioma.,2023,10.18632/aging.205179,https://pubmed.ncbi.nlm.nih.gov/37934565/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,33813137,A circular network of coregulated sphingolipids dictates lung cancer growth and progression.,2021,10.1016/j.ebiom.2021.103301,https://pubmed.ncbi.nlm.nih.gov/33813137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,35526049,Elevated transcription and glycosylation of B3GNT5 promotes breast cancer aggressiveness.,2022,10.1186/s13046-022-02375-5,https://pubmed.ncbi.nlm.nih.gov/35526049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,37781041,Role of glycosphingolipid biosynthesis coregulators in malignant progression of thymoma.,2023,10.7150/ijbs.83468,https://pubmed.ncbi.nlm.nih.gov/37781041/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,38989182,Prediction of immune molecules activity during burn wound healing among elderly patients: in-silico analyses: experimental research.,2024,10.1097/ms9.0000000000002055,https://pubmed.ncbi.nlm.nih.gov/38989182/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,34859256,lncRNA MIR4435‑2HG promotes the progression of liver cancer by upregulating B3GNT5 expression.,2022,10.3892/mmr.2021.12554,https://pubmed.ncbi.nlm.nih.gov/34859256/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,32677340,B3GNT5 is a novel marker correlated with stem-like phenotype and poor clinical outcome in human gliomas.,2020,10.1111/cns.13439,https://pubmed.ncbi.nlm.nih.gov/32677340/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,35069843,Potential biomarkers of acute myocardial infarction based on co-expression network analysis.,2022,10.3892/etm.2021.11085,https://pubmed.ncbi.nlm.nih.gov/35069843/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,33271119,The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses.,2021,10.1016/j.immuni.2020.11.003,https://pubmed.ncbi.nlm.nih.gov/33271119/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,34195201,The C-X-C Motif Chemokine Ligand 1 Sustains Breast Cancer Stem Cell Self-Renewal and Promotes Tumor Progression and Immune Escape Programs.,2021,10.3389/fcell.2021.689286,https://pubmed.ncbi.nlm.nih.gov/34195201/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,20547865,"Lack of lacto/neolacto-glycolipids enhances the formation of glycolipid-enriched microdomains, facilitating B cell activation.",2010,10.1073/pnas.0914298107,https://pubmed.ncbi.nlm.nih.gov/20547865/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,21087515,"Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis.",2010,10.1186/1471-213x-10-114,https://pubmed.ncbi.nlm.nih.gov/21087515/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,29187900,The cytotoxic effects of dimethyl sulfoxide in mouse preimplantation embryos: a mechanistic study.,2017,10.7150/thno.21662,https://pubmed.ncbi.nlm.nih.gov/29187900/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,25655580,Glycan-related gene expression signatures in breast cancer subtypes; relation to survival.,2015,10.1016/j.molonc.2014.12.013,https://pubmed.ncbi.nlm.nih.gov/25655580/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,21156036,DNA methylation in glioblastoma: impact on gene expression and clinical outcome.,2010,10.1186/1471-2164-11-701,https://pubmed.ncbi.nlm.nih.gov/21156036/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
B3GNT5,ENSG00000176597,Unsafe,11283017,"Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids.",2001,10.1074/jbc.m011369200,https://pubmed.ncbi.nlm.nih.gov/11283017/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42805912,HBx Enhances the Nrf2/ARE-dependent Antioxidant Response by Promoting Nuclear Export and Downregulation of Bach1.,2026,10.24546/0100505589,https://pubmed.ncbi.nlm.nih.gov/42805912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42029122,YTHDC1 Promotes Triple-Negative Breast Cancer Cell Proliferation and Stemness by Regulating BACH1 mRNA Stability in an m6A-Dependent Manner.,2026,10.1158/1541-7786.mcr-25-0602,https://pubmed.ncbi.nlm.nih.gov/42029122/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42177227,Nrf2/Bach1-ARE pathway are involved in the ameliorative effects of astaxanthin on D-galactose-induced liver and brain aging and injury.,2026,10.1038/s41598-026-52939-0,https://pubmed.ncbi.nlm.nih.gov/42177227/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42510566,Elevated BACH1 Contributes to Mitochondrial Succinylome Remodeling and Trophoblast Bioenergetic Dysfunction in Preeclampsia.,2026,10.3390/antiox15070835,https://pubmed.ncbi.nlm.nih.gov/42510566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42341848,BACH1 inhibition confers neuroprotection after subarachnoid hemorrhage through activation of the Nrf2 signaling pathway.,2026,10.1016/j.brainresbull.2026.112019,https://pubmed.ncbi.nlm.nih.gov/42341848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42503861,Clinical Relevance of BACH1 Expression in Non-Small Cell Lung Cancer.,2026,10.1002/ijc.70673,https://pubmed.ncbi.nlm.nih.gov/42503861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42269013,BACH1 orchestrates macrophage state transitions to coordinate regenerative inflammation.,2026,10.1093/jimmun/vkag101,https://pubmed.ncbi.nlm.nih.gov/42269013/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42468527,The transcription factor BACH1 couples chromatin priming and repression to enable macrophage plasticity and adaptation.,2026,10.1016/j.immuni.2026.06.022,https://pubmed.ncbi.nlm.nih.gov/42468527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42296473,Renal expression of Bach1 and oxidative stress in chronic kidney disease: evidence from a preclinical model.,2026,10.1590/2175-8239-jbn-2025-0333en,https://pubmed.ncbi.nlm.nih.gov/42296473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,41962531,A spinal USP7-Bach1 positive feedback loop drives NOX4-mediated ferroptosis in neuropathic pain.,2026,10.1016/j.redox.2026.104153,https://pubmed.ncbi.nlm.nih.gov/41962531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42801842,Pharmacological inhibition of USP14 attenuates LPS-induced septic myocardial injury by rebalancing Bach1/Nrf2 signalling and mitochondrial quality control.,2026,10.1016/j.intimp.2026.117488,https://pubmed.ncbi.nlm.nih.gov/42801842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42780883,Ferroptosis-driven cell death perpetuates the chronic inflammatory cycle in periodontitis: a single-cell transcriptomic study.,2026,10.3389/fcell.2026.1904996,https://pubmed.ncbi.nlm.nih.gov/42780883/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42265088,BACH1 stabilization by antioxidants facilitates hepatocellular carcinoma metastasis.,2026,10.1038/s41419-026-08865-0,https://pubmed.ncbi.nlm.nih.gov/42265088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42178570,A positive feedback loop between BACH1 and IL-1β promotes the progression of HPV-negative head and neck squamous cell carcinoma.,2026,10.1186/s12964-026-02957-2,https://pubmed.ncbi.nlm.nih.gov/42178570/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,41756515,BACH1-mediated transcriptional repression of pro-angiogenic factors drives angiogenic impairment in hypertension.,2026,10.3389/fcvm.2026.1769747,https://pubmed.ncbi.nlm.nih.gov/41756515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,41826889,Ferroptosis-related gene BACH1 is associated with preeclampsia and shows potential as a biomarker.,2026,10.1186/s12884-026-08884-x,https://pubmed.ncbi.nlm.nih.gov/41826889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42049998,Protective effects of skin-derived precursor cell exosomes against UVB-induced skin photodamage.,2026,10.1038/s41598-026-48604-1,https://pubmed.ncbi.nlm.nih.gov/42049998/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42509749,Targeting the hsa-miR-155-5p-BACH1-MMP-9 Signaling Hub in Lung Cancer: A Novel Anticancer Mechanism of Thymoquinone.,2026,10.3390/biom16070955,https://pubmed.ncbi.nlm.nih.gov/42509749/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42296678,PARK7 alleviates high-altitude pulmonary edema by suppressing BACH1 to attenuate lipid peroxidation-driven pro-inflammatory skewing of macrophages.,2026,10.1016/j.prp.2026.156566,https://pubmed.ncbi.nlm.nih.gov/42296678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42100250,"BACH transcription factors in diseases of the exocrine and endocrine pancreas: effects, mechanisms, and clinical implications.",2026,10.3389/fmed.2026.1805552,https://pubmed.ncbi.nlm.nih.gov/42100250/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42186808,Hypoxia Upregulation of BACH1 Aggravates Pulmonary Hypertension Through TGFBR2/SMAD Pathways.,2026,10.1161/circulationaha.124.073606,https://pubmed.ncbi.nlm.nih.gov/42186808/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42085862,Development of a high-throughput screening platform for identification of functional BACH1 inhibitors reveals compounds with anti-invasive potential.,2026,10.1016/j.redox.2026.104187,https://pubmed.ncbi.nlm.nih.gov/42085862/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,41652971,The neuronal ALAS2/5-ala axis mitigates chemotherapy-induced neurotoxicity via the BACH1/NRF2 pathway.,2026,10.1111/bph.70358,https://pubmed.ncbi.nlm.nih.gov/41652971/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,40563308,"Harnessing Antioxidants in Cancer Therapy: Opportunities, Challenges, and Future Directions.",2025,10.3390/antiox14060674,https://pubmed.ncbi.nlm.nih.gov/40563308/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,41606641,BPC157 drives angiogenesis through FBXO22-dependent stabilization of BACH1.,2026,10.1186/s12964-026-02694-6,https://pubmed.ncbi.nlm.nih.gov/41606641/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,40676837,A BACH1 inhibitor ameliorates myocardial infarction and limb ischemia in mice.,2025,10.1016/j.ymthe.2025.07.008,https://pubmed.ncbi.nlm.nih.gov/40676837/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,41912851,Enhancement of Rotenone Cytotoxicity in the Presence of Bach1 Inhibitors.,2026,10.1134/s1607672925601817,https://pubmed.ncbi.nlm.nih.gov/41912851/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,41316920,Crucial Contribution of BACH1 to Bladder Cancer Progression via Upregulating Epithelial-Mesenchymal Transition Pathway.,2026,10.1111/cas.70284,https://pubmed.ncbi.nlm.nih.gov/41316920/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,41239487,miR-629-3p affects postmenopausal osteoporosis through targeted regulation of BACH1.,2025,10.1186/s13018-025-06413-8,https://pubmed.ncbi.nlm.nih.gov/41239487/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42614148,"Endothelial EPAS1 as a prognostic and therapeutic target in acute myocardial infarction: integrative bioinformatics, Mendelian randomization and experimental validation.",2026,10.3389/fphar.2026.1893164,https://pubmed.ncbi.nlm.nih.gov/42614148/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,39347790,Iron TAMs: The fallen protectors.,2024,10.1084/jem.20240951,https://pubmed.ncbi.nlm.nih.gov/39347790/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,42576281,"Differential Modulation of Keratinocyte Proliferation, Differentiation, and Barrier Function by Hemp Oil, Blackcurrant Seed Oil, and Vitamin D&lt;sub&gt;3&lt;/sub&gt; Under Atopic-Associated Cytokine Stimulation.",2026,10.1002/biof.70137,https://pubmed.ncbi.nlm.nih.gov/42576281/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,41059410,The BAF53A-BACH1-GCLM axis regulates glutathione metabolism and enhances ferroptosis resistance in esophageal squamous cell carcinoma.,2025,10.7717/peerj.20156,https://pubmed.ncbi.nlm.nih.gov/41059410/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,41154512,Dissecting the Interplay Between NRF2 and BACH1 at CsMBEs.,2025,10.3390/antiox14101203,https://pubmed.ncbi.nlm.nih.gov/41154512/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH1,ENSG00000156273,Unsafe,39887888,The Multifaceted Roles of BACH1 in Disease: Implications for Biological Functions and Therapeutic Applications.,2025,10.1002/advs.202412850,https://pubmed.ncbi.nlm.nih.gov/39887888/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,42898127,Disseminated BCG disease and recurrent pulmonary infections in a child with trisomy 21 carrying a novel &lt;i&gt;BACH2&lt;/i&gt; variant of uncertain significance: a 5-year case report.,2026,10.3389/fmed.2026.1934925,https://pubmed.ncbi.nlm.nih.gov/42898127/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,42670393,BACH2 ameliorates lung injury in LPS-induced sepsis through activation of Nrf2 signaling.,2026,10.1007/s10616-026-01024-5,https://pubmed.ncbi.nlm.nih.gov/42670393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,42568828,LIPUS combined with mild hyperthermia promotes rotator cuff healing via TRPV1/Ca&lt;sup&gt;2+&lt;/sup&gt;/CaMKII-driven BACH2 nuclear translocation and inhibition of M1 polarization.,2026,10.1016/j.jot.2026.101170,https://pubmed.ncbi.nlm.nih.gov/42568828/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,42900669,"Selective persistence of HIV-1-infected T cell clones can occur through immune reprogramming driven by defective, transcriptionally active proviruses.",2026,10.1371/journal.ppat.1014618,https://pubmed.ncbi.nlm.nih.gov/42900669/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,42503483,BACH2 Exacerbates Bronchopulmonary Dysplasia by Promoting NCOA4-Dependent Ferritinophagy via Transcriptional Activation of JUN.,2026,10.1177/15230864261471273,https://pubmed.ncbi.nlm.nih.gov/42503483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,42130341,BACH2 effector-to-memory switch promotes HIV persistence and CAR-T efficacy.,2026,10.1097/coh.0000000000001041,https://pubmed.ncbi.nlm.nih.gov/42130341/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,42816612,Human genetics implicates a BACH2-NRF2 axis in fetal haemoglobin activation.,2026,10.1038/s41586-026-11113-2,https://pubmed.ncbi.nlm.nih.gov/42816612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,42671003,Enhancer of zeste homolog 2 regulates B-cell responses in a NOD.H-2h4 model of spontaneous autoimmune thyroiditis.,2026,10.1210/endocr/bqag096,https://pubmed.ncbi.nlm.nih.gov/42671003/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,41827001,Myeloid-derived immunosuppression of chimeric antigen receptor T cells in the neuronal microenvironment of glioblastoma.,2026,10.1186/s12916-026-04783-2,https://pubmed.ncbi.nlm.nih.gov/41827001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,42047686,BACH2 controls ILC3 function via PPARγ-dependent mitochondrial metabolism.,2026,10.1084/jem.20251918,https://pubmed.ncbi.nlm.nih.gov/42047686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,41169388,&lt;i&gt;Bach2&lt;/i&gt;-deficient mice are prone to autoimmune pancreatitis but protected from high-fat diet-induced fatty liver disease.,2025,10.3389/fimmu.2025.1639622,https://pubmed.ncbi.nlm.nih.gov/41169388/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,42700546,Preliminary analysis of chromatin accessibility in osteosarcoma tissues.,2026,10.1016/j.clinsp.2026.101115,https://pubmed.ncbi.nlm.nih.gov/42700546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,41462398,Daphnetin alleviates unexplained recurrent spontaneous abortion by regulating the NR4A1/BACH2 axis in mice.,2025,10.1186/s40659-025-00658-7,https://pubmed.ncbi.nlm.nih.gov/41462398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,42077849,Peptide Design for Targeting BTB Domain Homodimerization of BACH2: Complementary &lt;i&gt;In Silico&lt;/i&gt; and &lt;i&gt;In Vitro&lt;/i&gt; Approaches.,2026,10.1021/acsomega.6c01122,https://pubmed.ncbi.nlm.nih.gov/42077849/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,42100250,"BACH transcription factors in diseases of the exocrine and endocrine pancreas: effects, mechanisms, and clinical implications.",2026,10.3389/fmed.2026.1805552,https://pubmed.ncbi.nlm.nih.gov/42100250/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,41665976,BACH2 alleviates immune checkpoint inhibitors-induced cardiac pyroptosis via transcriptionally promoting GRSF1.,2026,10.1002/ctm2.70618,https://pubmed.ncbi.nlm.nih.gov/41665976/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,41545542,BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells.,2026,10.1038/s41590-025-02388-0,https://pubmed.ncbi.nlm.nih.gov/41545542/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,42820929,Helios is critical for Treg effector differentiation in adipose autoimmunity.,2026,10.1084/jem.20260870,https://pubmed.ncbi.nlm.nih.gov/42820929/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,40845840,BACH2 promotes seeding and establishment of long-lived HIV-1 reservoir in memory CD4&lt;sup&gt;+&lt;/sup&gt; T cells.,2025,10.1016/j.xcrm.2025.102311,https://pubmed.ncbi.nlm.nih.gov/40845840/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,42257674,Bidirectional regulation by BACH2 coordinates systemic CXCR5- vs. CXCR5+ CD4+ T cell differentiation.,2026,10.1084/jem.20251959,https://pubmed.ncbi.nlm.nih.gov/42257674/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,41545540,BACH2 regulates T cell lineage state to enhance CAR T cell function.,2026,10.1038/s41590-025-02391-5,https://pubmed.ncbi.nlm.nih.gov/41545540/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,42457339,"&lt;i&gt;Sleeping Beauty&lt;/i&gt; mutagenesis identifies &lt;i&gt;BACH2&lt;/i&gt; and other regulators of CD8&lt;sup&gt;+&lt;/sup&gt; T-cell exhaustion, persistence in vivo, and CAR-T cell function under tumor-associated chronic antigen stimulation.",2026,10.1136/jitc-2025-013536,https://pubmed.ncbi.nlm.nih.gov/42457339/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,41847468,Dynamic regulation of BACH2 enhances CAR T cell function.,2026,10.1016/j.omton.2026.201164,https://pubmed.ncbi.nlm.nih.gov/41847468/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,41545541,Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy.,2026,10.1038/s41590-025-02389-z,https://pubmed.ncbi.nlm.nih.gov/41545541/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,41819072,Vitamin B6 modulates CD8&lt;sup&gt;+&lt;/sup&gt; T cell antitumor responses.,2026,10.1016/j.devcel.2026.02.015,https://pubmed.ncbi.nlm.nih.gov/41819072/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,41614877,Downregulated Expression of the IL7R and BACH2 Genes Is Associated with Immune Memory Loss in Adults Vaccinated Against HBV at Birth.,2025,10.3390/cimb48010047,https://pubmed.ncbi.nlm.nih.gov/41614877/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,42031636,Proteasome-haem-BACH2 axis fuels T cell exhaustion.,2026,10.1016/j.it.2026.04.002,https://pubmed.ncbi.nlm.nih.gov/42031636/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,42765973,"A Phase I/II Trial of Anti-CD22/CD19 CAR-T Cell Therapy, CART2219.1, in Adult and Pediatric Relapsed/Refractory B-ALL.",2026,10.1158/2643-3230.bcd-26-0115,https://pubmed.ncbi.nlm.nih.gov/42765973/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,42095075,Single-cell transcriptomics reveal altered B cell responses and T cell senescence in geriatric non-responders to COVID-19 mRNA vaccination.,2026,10.1016/j.isci.2026.115730,https://pubmed.ncbi.nlm.nih.gov/42095075/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BACH2,ENSG00000112182,Unsafe,41851457,Proteasome-guided haem signalling axis contributes to T cell exhaustion.,2026,10.1038/s41586-026-10250-y,https://pubmed.ncbi.nlm.nih.gov/41851457/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,41108541,Genome-Wide Association Study of Cognitive Function in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study.,2025,10.1111/gbb.70038,https://pubmed.ncbi.nlm.nih.gov/41108541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,41459802,Nucleoporin NUP210L and BAF-paralogue BAF-L redundantly ensure nuclear integrity and manchette microtubule organisation in mouse spermatids.,2026,10.1093/hmg/ddaf194,https://pubmed.ncbi.nlm.nih.gov/41459802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,41063647,Before the East African Radiation: Sex Chromosome Systems in Basal Haplotilapiine Cichlids.,2026,10.1093/gbe/evaf191,https://pubmed.ncbi.nlm.nih.gov/41063647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,33951625,Mus musculus Barrier-To-Autointegration Factor 2 (Banf2) is Not Essential for Spermatogenesis or Fertility.,2021,10.1159/000513850,https://pubmed.ncbi.nlm.nih.gov/33951625/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,40663988,"A timecourse analysis of gonadal histology and transcriptome during the sexual development of yellow catfish, Pelteobagrus fulvidraco.",2025,10.1016/j.cbd.2025.101576,https://pubmed.ncbi.nlm.nih.gov/40663988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,36270036,"4,4'-(9-Fluorenylidene)dianiline (BAFL) is antiestrogenic and has adverse effects on female development in CD-1 mice.",2022,10.1016/j.ecoenv.2022.114202,https://pubmed.ncbi.nlm.nih.gov/36270036/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,41193525,"Quantum deep learning-enhanced ethereum blockchain for cloud security: intrusion detection, fraud prevention, and secure data migration.",2025,10.1038/s41598-025-22408-1,https://pubmed.ncbi.nlm.nih.gov/41193525/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,34209244,Gene Variant of Barrier to Autointegration Factor 2 (Banf2w) Is Concordant with Female Determination in Cichlids.,2021,10.3390/ijms22137073,https://pubmed.ncbi.nlm.nih.gov/34209244/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,32026202,"Obesity significantly alters the human sperm proteome, with potential implications for fertility.",2020,10.1007/s10815-020-01707-8,https://pubmed.ncbi.nlm.nih.gov/32026202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,31451927,Comparative Study of Cytokine Levels in Different Respiratory Samples in Mild-to-Moderate AECOPD Patients.,2019,10.1007/s00408-019-00263-y,https://pubmed.ncbi.nlm.nih.gov/31451927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,23006766,The LO-BaFL method and ALS microarray expression analysis.,2012,10.1186/1471-2105-13-244,https://pubmed.ncbi.nlm.nih.gov/23006766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,36277249,The Comparison of Metagenomic Next-Generation Sequencing with Conventional Microbiological Tests for Identification of Pathogens and Antibiotic Resistance Genes in Infectious Diseases.,2022,10.2147/idr.s370964,https://pubmed.ncbi.nlm.nih.gov/36277249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,24722316,Dexamethasone ameliorates H₂S-induced acute lung injury by alleviating matrix metalloproteinase-2 and -9 expression.,2014,10.1371/journal.pone.0094701,https://pubmed.ncbi.nlm.nih.gov/24722316/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,20040098,A white-box approach to microarray probe response characterization: the BaFL pipeline.,2009,10.1186/1471-2105-10-449,https://pubmed.ncbi.nlm.nih.gov/20040098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,29580276,Indicators for prediction of Mycobacterium tuberculosis positivity detected with bronchoalveolar lavage fluid.,2018,10.1186/s40249-018-0403-x,https://pubmed.ncbi.nlm.nih.gov/29580276/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,18705003,[Establishment and characteristics of acute lung injury model induced by cigarette smoke in ICR mice].,2008,10.3785/j.issn.1008-9292.2008.04.002,https://pubmed.ncbi.nlm.nih.gov/18705003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,16522239,[Protective effects of captopril on hyperoxia-induced lung injury in neonatal rats].,2006,,https://pubmed.ncbi.nlm.nih.gov/16522239/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,38301411,Interleukin-36 receptor antagonist stimulation in vitro inhibits peripheral and lung-resident T cell response isolated from patients with ventilator-associated pneumonia.,2024,10.1016/j.intimp.2024.111513,https://pubmed.ncbi.nlm.nih.gov/38301411/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BANF2,ENSG00000125888,Unsafe,17259154,[Effect of ulinastatin on inflammatory responses induced by oesophagectomy].,2007,,https://pubmed.ncbi.nlm.nih.gov/17259154/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,42181240,Temporal control of midline crossing via incoherent feedforward and feedback loops regulating Robo3.,2026,10.1016/j.isci.2026.115912,https://pubmed.ncbi.nlm.nih.gov/42181240/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,39753777,Interfacial water confers transcription factors with dinucleotide specificity.,2025,10.1038/s41594-024-01449-6,https://pubmed.ncbi.nlm.nih.gov/39753777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,34901027,T-Cell Factors as Transcriptional Inhibitors: Activities and Regulations in Vertebrate Head Development.,2021,10.3389/fcell.2021.784998,https://pubmed.ncbi.nlm.nih.gov/34901027/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,39307290,Role of Elavl-like RNA-binding protein in retinal development and signal transduction.,2025,10.1016/j.bbadis.2024.167518,https://pubmed.ncbi.nlm.nih.gov/39307290/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,32483163,Expression of a Barhl1a reporter in subsets of retinal ganglion cells and commissural neurons of the developing zebrafish brain.,2020,10.1038/s41598-020-65435-w,https://pubmed.ncbi.nlm.nih.gov/32483163/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,37082886,Association of frequent hypermethylation with high grade histological subtype in lung adenocarcinoma.,2023,10.1111/cas.15817,https://pubmed.ncbi.nlm.nih.gov/37082886/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,36719625,Identification of lncRNA-miRNA-mRNA Regulatory Network and Therapeutic Agents for Skin Aging by Bioinformatics Analysis.,2023,10.1007/s10528-023-10334-8,https://pubmed.ncbi.nlm.nih.gov/36719625/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,27887593,Expression of Barhl2 and its relationship with Pax6 expression in the forebrain of the mouse embryo.,2016,10.1186/s12868-016-0311-6,https://pubmed.ncbi.nlm.nih.gov/27887593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,27349434,Barhl2 Determines the Early Patterning of the Diencephalon by Regulating Shh.,2017,10.1007/s12035-016-0001-5,https://pubmed.ncbi.nlm.nih.gov/27349434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,35741748,Genome-Wide Association Study of Potential Meat Quality Trait Loci in Ducks.,2022,10.3390/genes13060986,https://pubmed.ncbi.nlm.nih.gov/35741748/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,27441821,BARHL2 Methylation Using Gastric Wash DNA or Gastric Juice Exosomal DNA is a Useful Marker For Early Detection of Gastric Cancer in an H. pylori-Independent Manner.,2016,10.1038/ctg.2016.40,https://pubmed.ncbi.nlm.nih.gov/27441821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,31036545,Barhl2 maintains T cell factors as repressors and thereby switches off the Wnt/β-Catenin response driving Spemann organizer formation.,2019,10.1242/dev.173112,https://pubmed.ncbi.nlm.nih.gov/31036545/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,34276786,Expression Profiling and Functional Analysis of Candidate Col10a1 Regulators Identified by the TRAP Program.,2021,10.3389/fgene.2021.683939,https://pubmed.ncbi.nlm.nih.gov/34276786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,30902784,Intron polymorphisms of MAGI-1 and ACSF2 and effects on their expression in different goose breeds.,2019,10.1016/j.gene.2019.02.102,https://pubmed.ncbi.nlm.nih.gov/30902784/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,32842956,Genetic control of temperament traits across species: association of autism spectrum disorder risk genes with cattle temperament.,2020,10.1186/s12711-020-00569-z,https://pubmed.ncbi.nlm.nih.gov/32842956/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,25281935,The conserved barH-like homeobox-2 gene barhl2 acts downstream of orthodentricle-2 and together with iroquois-3 in establishment of the caudal forebrain signaling center induced by Sonic Hedgehog.,2014,10.1016/j.ydbio.2014.09.027,https://pubmed.ncbi.nlm.nih.gov/25281935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,21262809,Barhl2 limits growth of the diencephalic primordium through Caspase3 inhibition of beta-catenin activation.,2011,10.1073/pnas.1014017108,https://pubmed.ncbi.nlm.nih.gov/21262809/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,34811809,Combination of artificial intelligence-based endoscopy and miR148a methylation for gastric indefinite dysplasia diagnosis.,2022,10.1002/jcla.24122,https://pubmed.ncbi.nlm.nih.gov/34811809/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,22307612,BARHL2 transcription factor regulates the ipsilateral/contralateral subtype divergence in postmitotic dI1 neurons of the developing spinal cord.,2012,10.1073/pnas.1112392109,https://pubmed.ncbi.nlm.nih.gov/22307612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,23035102,Biasing amacrine subtypes in the Atoh7 lineage through expression of Barhl2.,2012,10.1523/jneurosci.2073-12.2012,https://pubmed.ncbi.nlm.nih.gov/23035102/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BARHL2,ENSG00000143032,Unsafe,39011998,"Fusion Genes Landscape of Lung Cancer Patients From Inner Mongolia, China.",2024,10.1002/gcc.23258,https://pubmed.ncbi.nlm.nih.gov/39011998/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,42316211,Bardet-Biedl syndrome 1 mutations differentially impact BBSome integrity and ciliary trafficking.,2026,10.1186/s12964-026-03006-8,https://pubmed.ncbi.nlm.nih.gov/42316211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,42454257,Smoking-Related Clinical and Molecular Abnormalities in Idiopathic Pulmonary Fibrosis-Associated Pulmonary Hypertension.,2026,10.1002/pul2.70349,https://pubmed.ncbi.nlm.nih.gov/42454257/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,40744313,The brainstem BBSome regulates glucose homeostasis and lean mass in a state-dependent manner.,2025,10.1016/j.molmet.2025.102222,https://pubmed.ncbi.nlm.nih.gov/40744313/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,42438042,Atypical Prenatal Phenotypic Spectrum: A Case Series of Four Unique Presentations With Genetic and Diagnostic Insights.,2026,10.1111/cge.70214,https://pubmed.ncbi.nlm.nih.gov/42438042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,42022048,Genetic and Phenotypic Characterization of a Large Cohort of Patients with BBS1-Retinopathy.,2026,10.1016/j.xops.2026.101164,https://pubmed.ncbi.nlm.nih.gov/42022048/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,40923755,Genomic Analysis for the Safety Assessment of a Potential Probiotic Strain Pediococcus pentosaceus BBS1 Isolated From Lao Fermented Bamboo Shoots (Nor Mai Som).,2025,10.1002/mbo3.70048,https://pubmed.ncbi.nlm.nih.gov/40923755/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,41193622,Phosphoproteomic profiling highlights CDC42 and CDK2 as key players in the regulation of the TGF-β pathway in ALMS1 and BBS1 knockout models.,2025,10.1038/s41598-025-22584-0,https://pubmed.ncbi.nlm.nih.gov/41193622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,40718228,Analysis of the Body Mass Index of Latino Patients With Bardet-Biedl Syndrome.,2025,10.7759/cureus.86744,https://pubmed.ncbi.nlm.nih.gov/40718228/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,38738295,Adipocyte-specific disruption of the BBSome causes metabolic and autonomic dysfunction.,2024,10.1152/ajpregu.00039.2024,https://pubmed.ncbi.nlm.nih.gov/38738295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,42156840,Genetic determinants of drug-induced gingival overgrowth.,2026,10.1038/s41598-026-52779-y,https://pubmed.ncbi.nlm.nih.gov/42156840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,42724349,Whole-exome sequencing-centered genetic evaluation for early-onset obesity in Chinese children: a retrospective single-center cohort.,2026,10.21037/tp-2026-0407,https://pubmed.ncbi.nlm.nih.gov/42724349/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,41624286,Transcription factor BRCA1 is associated with BMPR1B transcriptional activity in sheep ovarian granulosa cells.,2025,10.3389/fvets.2025.1722859,https://pubmed.ncbi.nlm.nih.gov/41624286/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,41552087,Retinal Degeneration and Visual Outcomes in Patients With Bardet-Biedl Syndrome: Genotypic Influences From a Caribbean Cohort.,2025,10.7759/cureus.99380,https://pubmed.ncbi.nlm.nih.gov/41552087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,42667617,Mesenchymal drift in ciliopathy iPSC-derived RPE reveals a convergent pathogenic cell state.,2026,10.1016/j.celrep.2026.117906,https://pubmed.ncbi.nlm.nih.gov/42667617/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,40757108,Berg Balance Scale in post-COVID-19 patients: results from a retrospective study.,2025,10.25122/jml-2025-0098,https://pubmed.ncbi.nlm.nih.gov/40757108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,42774553,A comprehensive overview of genetic mutations in Iranian patients with Bardet-Biedl syndrome.,2026,10.1016/j.ymgmr.2026.101357,https://pubmed.ncbi.nlm.nih.gov/42774553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,39658238,Clinical variability of &lt;i&gt;BBS1&lt;/i&gt; across siblings.,2024,10.1136/bcr-2024-261874,https://pubmed.ncbi.nlm.nih.gov/39658238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,38223458,POMC Neuron BBSome Regulation of Body Weight is Independent of its Ciliary Function.,2024,10.1093/function/zqad070,https://pubmed.ncbi.nlm.nih.gov/38223458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,40257378,FGFR2 residence in primary cilia is necessary for epithelial cell signaling.,2025,10.1083/jcb.202311030,https://pubmed.ncbi.nlm.nih.gov/40257378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,37909854,Metabolic consequences of skeletal muscle- and liver-specific BBSome deficiency.,2023,10.1152/ajpendo.00174.2023,https://pubmed.ncbi.nlm.nih.gov/37909854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,42905171,"[Bardet-Biedl syndrome-diagnosis, care and treatment approaches].",2026,10.1007/s00347-026-02539-0,https://pubmed.ncbi.nlm.nih.gov/42905171/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,36534590,T cell-specific deficiency in BBSome component BBS1 interferes with selective immune responses.,2023,10.1152/ajpregu.00243.2022,https://pubmed.ncbi.nlm.nih.gov/36534590/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,34423835,The Bardet-Biedl syndrome complex component BBS1 controls T cell polarity during immune synapse assembly.,2021,10.1242/jcs.258462,https://pubmed.ncbi.nlm.nih.gov/34423835/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,36744302,Ubiquitylation of BBSome is required for ciliary assembly and signaling.,2023,10.15252/embr.202255571,https://pubmed.ncbi.nlm.nih.gov/36744302/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,33664503,"Ectopic expression of BBS1 rescues male infertility, but not retinal degeneration, in a BBS1 mouse model.",2022,10.1038/s41434-021-00241-1,https://pubmed.ncbi.nlm.nih.gov/33664503/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,40804693,Etiology and outcomes of fetal renal abnormalities in Southern China: a single-tertiary-center study.,2025,10.1186/s13023-025-03970-3,https://pubmed.ncbi.nlm.nih.gov/40804693/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,34526762,A Genotype-Phenotype Analysis of the Bardet-Biedl Syndrome in Puerto Rico.,2021,10.2147/opth.s328493,https://pubmed.ncbi.nlm.nih.gov/34526762/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,35960079,Novel homozygous nonsense mutation associated with Bardet-Biedl syndrome in fetuses with congenital renal malformation.,2022,10.1097/md.0000000000030003,https://pubmed.ncbi.nlm.nih.gov/35960079/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,35886001,Ophthalmic and Genetic Features of Bardet Biedl Syndrome in a German Cohort.,2022,10.3390/genes13071218,https://pubmed.ncbi.nlm.nih.gov/35886001/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,38155679,A visually guided swim assay for mouse models of human retinal disease recapitulates the multi-luminance mobility test in humans.,2023,10.4103/sjopt.sjopt_155_23,https://pubmed.ncbi.nlm.nih.gov/38155679/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,28237838,Gene Therapeutic Reversal of Peripheral Olfactory Impairment in Bardet-Biedl Syndrome.,2017,10.1016/j.ymthe.2017.02.006,https://pubmed.ncbi.nlm.nih.gov/28237838/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,23900607,Subretinal gene therapy of mice with Bardet-Biedl syndrome type 1.,2013,10.1167/iovs.13-11673,https://pubmed.ncbi.nlm.nih.gov/23900607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,23071606,Beneficial effect of antibodies against β- secretase cleavage site of APP on Alzheimer's-like pathology in triple-transgenic mice.,2012,10.1371/journal.pone.0046650,https://pubmed.ncbi.nlm.nih.gov/23071606/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,29971011,Osteoarthritis-Like Changes in Bardet-Biedl Syndrome Mutant Ciliopathy Mice (Bbs1M390R/M390R): Evidence for a Role of Primary Cilia in Cartilage Homeostasis and Regulation of Inflammation.,2018,10.3389/fphys.2018.00708,https://pubmed.ncbi.nlm.nih.gov/29971011/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,35966511,"Expression, Clinical Significance, Immune Infiltration, and Regulation Network of miR-3940-5p in Lung Adenocarcinoma Based on Bioinformatic Analysis and Experimental Validation.",2022,10.2147/ijgm.s375761,https://pubmed.ncbi.nlm.nih.gov/35966511/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BBS1,ENSG00000174483,Unsafe,22110077,TUDCA slows retinal degeneration in two different mouse models of retinitis pigmentosa and prevents obesity in Bardet-Biedl syndrome type 1 mice.,2012,10.1167/iovs.11-8544,https://pubmed.ncbi.nlm.nih.gov/22110077/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,42136029,Systemic dual-gene therapy reverses biochemical intoxication in the central metabolic compartment of Bckdha-/- mice.,2026,10.1016/j.ymthe.2026.05.008,https://pubmed.ncbi.nlm.nih.gov/42136029/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,42395269,Identification of neoadjuvant chemoradiotherapy resistance-associated proteins in locally advanced rectal cancer: A pilot study.,2026,10.3892/ol.2026.15722,https://pubmed.ncbi.nlm.nih.gov/42395269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,42008693,IDH3A Deficiency Compromises Adaptive Thermogenesis and Exacerbates Obesity-Induced Metabolic Dysfunction via Impaired BCKDHA-Dependent BCAA Catabolism.,2026,10.2337/db25-0789,https://pubmed.ncbi.nlm.nih.gov/42008693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,41444608,PRSS55 regulates BCAA metabolism and interacts with BCKDK and BCKDHA in mouse testes and sperm.,2025,10.1186/s13578-025-01511-w,https://pubmed.ncbi.nlm.nih.gov/41444608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,41224144,BCAA catabolism in TRH neurons of paraventricular nucleus regulates energy expenditure.,2026,10.1016/j.metabol.2025.156435,https://pubmed.ncbi.nlm.nih.gov/41224144/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,42450720,Regional Differences in Cardiac Marker Gene Expression and Branched-Chain Amino Acid Metabolism in the Bovine Heart.,2026,10.3390/ani16132014,https://pubmed.ncbi.nlm.nih.gov/42450720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,42172899,Reprogramming of hepatic BCAA metabolism by fructose exacerbates hepatic steatosis.,2026,10.1016/j.bbrc.2026.153999,https://pubmed.ncbi.nlm.nih.gov/42172899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,39389936,BCKDH kinase promotes hepatic gluconeogenesis independent of BCKDHA.,2024,10.1038/s41419-024-07071-0,https://pubmed.ncbi.nlm.nih.gov/39389936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,40009698,&lt;i&gt;BCKDHA-BCKDHB&lt;/i&gt; digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease.,2025,10.1126/scitranslmed.ads0539,https://pubmed.ncbi.nlm.nih.gov/40009698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,41560354,The Gut Commensal Butyricimonas Virosa Modulates Gut Microbiota-Dependent Thiamine Metabolism and Attenuates Mouse Steatotic Liver Disease.,2026,10.1002/advs.202517596,https://pubmed.ncbi.nlm.nih.gov/41560354/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,41013826,Adenine base editing rescues disrupted BCKDH function and reduces BCAAs toxic accumulation in maple syrup urine disease patient iPSC-hepatic organoids.,2025,10.1186/s13287-025-04630-w,https://pubmed.ncbi.nlm.nih.gov/41013826/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,39551140,Impaired branched-chain amino acid (BCAA) catabolism during adipocyte differentiation decreases glycolytic flux.,2024,10.1016/j.jbc.2024.108004,https://pubmed.ncbi.nlm.nih.gov/39551140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,40686115,[Mechanism of Qingrun Decoction in alleviating hepatic insulin resistance in type 2 diabetic rats based on amino acid metabolism reprogramming pathways].,2025,10.19540/j.cnki.cjcmm.20250120.701,https://pubmed.ncbi.nlm.nih.gov/40686115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,41282284,Sodium-glucose cotransporter 2 inhibitors-but not insulin-enhance renal branched-chain amino acid catabolism.,2025,10.3389/fendo.2025.1706838,https://pubmed.ncbi.nlm.nih.gov/41282284/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,42462529,"Total glucosides of paeony modulates leucine metabolism by inhibiting SLC7A5, antagonizing mTOR signaling to suppress head and neck squamous cell carcinoma.",2026,10.1016/j.phymed.2026.158576,https://pubmed.ncbi.nlm.nih.gov/42462529/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,42874231,"Effects of dietary net energy, crude protein, and standardized ileal digestible lysine on growth performance, nitrogen utilization, and hepatic metabolism in 22-35 day-old broilers.",2026,10.1016/j.psj.2026.107867,https://pubmed.ncbi.nlm.nih.gov/42874231/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,42617526,Integrated transcriptomic and metabolomic analyses provide new insights into the response of black rockfish (Sebastes schlegelii) larvae to temperature fluctuations.,2026,10.1016/j.cbd.2026.101976,https://pubmed.ncbi.nlm.nih.gov/42617526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,36749362,The mitochondrial BCKD complex interacts with hepatic apolipoprotein E in cultured cells in vitro and mouse livers in vivo.,2023,10.1007/s00018-023-04706-x,https://pubmed.ncbi.nlm.nih.gov/36749362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,37752100,PPM1K mediates metabolic disorder of branched-chain amino acid and regulates cerebral ischemia-reperfusion injury by activating ferroptosis in neurons.,2023,10.1038/s41419-023-06135-x,https://pubmed.ncbi.nlm.nih.gov/37752100/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,39773751,Comprehensive Iranian guidelines for the diagnosis and management of maple syrup urine disease: an evidence- and consensus- based approach.,2025,10.1186/s13023-025-03533-6,https://pubmed.ncbi.nlm.nih.gov/39773751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,39928435,Glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor agonist tirzepatide promotes branched chain amino acid catabolism to prevent myocardial infarction in non-diabetic mice.,2025,10.1093/cvr/cvaf005,https://pubmed.ncbi.nlm.nih.gov/39928435/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,39551846,Expanding the genotypic and phenotypic spectrum of Egyptian children with maple syrup urine disease.,2024,10.1038/s41598-024-78105-y,https://pubmed.ncbi.nlm.nih.gov/39551846/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,38837343,Genotypic and phenotypic spectrum of maple syrup urine disease in Zhejiang of China.,2024,10.1093/qjmed/hcae104,https://pubmed.ncbi.nlm.nih.gov/38837343/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,40049462,Indispensable role of PGC1α signaling in lipid and carbohydrate metabolism of fish PPARα activation.,2025,10.1016/j.ijbiomac.2025.141722,https://pubmed.ncbi.nlm.nih.gov/40049462/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,35672312,Neonatal gene therapy achieves sustained disease rescue of maple syrup urine disease in mice.,2022,10.1038/s41467-022-30880-w,https://pubmed.ncbi.nlm.nih.gov/35672312/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,40422699,Integrated Amino Acid Profiling and 4D-DIA Proteomics Reveal Protein Quality Divergence and Metabolic Adaptation in &lt;i&gt;Cordyceps&lt;/i&gt; Species.,2025,10.3390/jof11050365,https://pubmed.ncbi.nlm.nih.gov/40422699/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,39621302,The pyruvate dehydrogenase kinase inhibitor dichloroacetate mitigates alcohol-induced hepatic inflammation and metabolic disturbances in mice.,2024,10.1097/hc9.0000000000000547,https://pubmed.ncbi.nlm.nih.gov/39621302/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,36457754,Comprehensive analyses of the microRNA-messenger RNA-transcription factor regulatory network in mouse and human renal fibrosis.,2022,10.3389/fgene.2022.925097,https://pubmed.ncbi.nlm.nih.gov/36457754/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,36860449,Dietary Leucine Supplementation Improves Muscle Fiber Growth and Development by Activating AMPK/Sirt1 Pathway in Blunt Snout Bream (Megalobrama amblycephala).,2022,10.1155/2022/7285851,https://pubmed.ncbi.nlm.nih.gov/36860449/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,37216755,Loss of BCAA catabolism enhances Rab1A-mTORC1 signaling activity and promotes tumor proliferation in NSCLC.,2023,10.1016/j.tranon.2023.101696,https://pubmed.ncbi.nlm.nih.gov/37216755/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,31784505,Branched-chain amino acids sustain pancreatic cancer growth by regulating lipid metabolism.,2019,10.1038/s12276-019-0350-z,https://pubmed.ncbi.nlm.nih.gov/31784505/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,35799415,Genomic and biochemical analysis of repeatedly observed variants in DBT in individuals with maple syrup urine disease of Central American ancestry.,2022,10.1002/ajmg.a.62893,https://pubmed.ncbi.nlm.nih.gov/35799415/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,35499760,Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma.,2022,10.1158/0008-5472.can-21-3868,https://pubmed.ncbi.nlm.nih.gov/35499760/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,33996182,"Clinical, Biochemical, Molecular, and Therapeutic Analysis of Maple Syrup Urine Disease in Upper Egypt.",2021,10.1055/s-0040-1715111,https://pubmed.ncbi.nlm.nih.gov/33996182/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCKDHA,ENSG00000248098,Unsafe,34069211,Challenges in Diagnosing Intermediate Maple Syrup Urine Disease by Newborn Screening and Functional Validation of Genomic Results Imperative for Reproductive Family Planning.,2021,10.3390/ijns7020025,https://pubmed.ncbi.nlm.nih.gov/34069211/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,42899482,Tumour Antigen-Specific Antibody Signatures as Diagnostic Biomarkers for Melanoma.,2026,10.1002/ijc.70726,https://pubmed.ncbi.nlm.nih.gov/42899482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,40491783,Integration of Bulk and Single-Cell Transcriptomics Reveals BCL2L14 as a Novel IGKC+ T Cell-Associated Therapeutic Target in Breast Cancer.,2025,10.2147/jir.s523147,https://pubmed.ncbi.nlm.nih.gov/40491783/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,41866100,Single-cell sequencing reveals metabolic reprogramming and immune regulation underlie the maintenance of teleost granulomas.,2026,10.1016/j.fsi.2026.111287,https://pubmed.ncbi.nlm.nih.gov/41866100/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,39080788,DNA methylation and whole-genome transcription analysis in CD4+ T cells from systemic lupus erythematosus patients with or without renal damage.,2024,10.1186/s13148-024-01699-7,https://pubmed.ncbi.nlm.nih.gov/39080788/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,39662639,Multiomics identification of programmed cell death-related characteristics for nonobstructive azoospermia based on a 675-combination machine learning computational framework.,2025,10.1016/j.ygeno.2024.110977,https://pubmed.ncbi.nlm.nih.gov/39662639/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,42617351,Machine learning-enabled multi-omics discovery of prognostic biomarkers and signaling targets in pancreatic cancer.,2026,10.1016/j.compbiolchem.2026.109320,https://pubmed.ncbi.nlm.nih.gov/42617351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,40862527,Effects and mechanism of the timing of alfalfa hay supplementation on rumen development of Hu lambs.,2025,10.1093/jas/skaf227,https://pubmed.ncbi.nlm.nih.gov/40862527/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,40430278,Curcumin-Induced Molecular Mechanisms in U-87 MG Glioblastoma Cells: Insights from Global Gene Expression Profiling.,2025,10.3390/molecules30102108,https://pubmed.ncbi.nlm.nih.gov/40430278/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,40175857,Analysis of Multiple Programmed Cell Death Patterns and Functional Validations of Apoptosis-Associated Genes in Lung Adenocarcinoma.,2025,10.1245/s10434-025-17224-w,https://pubmed.ncbi.nlm.nih.gov/40175857/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,37031274,BCL-G: 20 years of research on a non-typical protein from the BCL-2 family.,2023,10.1038/s41418-023-01158-5,https://pubmed.ncbi.nlm.nih.gov/37031274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,38814387,Epigenetic Insights Into Necrotizing Enterocolitis: Unraveling Methylation-Regulated Biomarkers.,2025,10.1007/s10753-024-02054-x,https://pubmed.ncbi.nlm.nih.gov/38814387/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,40252140,ChIP-seq and RNA-seq Reveal the Involvement of Histone Lactylation Modification in Early Pregnancy with Subclinical Hypothyroidism.,2026,10.1007/s10528-025-11095-2,https://pubmed.ncbi.nlm.nih.gov/40252140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,32321829,Landscape analysis of adjacent gene rearrangements reveals BCL2L14-ETV6 gene fusions in more aggressive triple-negative breast cancer.,2020,10.1073/pnas.1921333117,https://pubmed.ncbi.nlm.nih.gov/32321829/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,30075151,"Medullary Breast Carcinoma, a Triple-Negative Breast Cancer Associated with BCLG Overexpression.",2018,10.1016/j.ajpath.2018.06.021,https://pubmed.ncbi.nlm.nih.gov/30075151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,35106856,"Fusion-associated carcinomas of the breast: Diagnostic, prognostic, and therapeutic significance.",2022,10.1002/gcc.23029,https://pubmed.ncbi.nlm.nih.gov/35106856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,31988296,Human BCL-G regulates secretion of inflammatory chemokines but is dispensable for induction of apoptosis by IFN-γ and TNF-α in intestinal epithelial cells.,2020,10.1038/s41419-020-2263-0,https://pubmed.ncbi.nlm.nih.gov/31988296/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,30597231,Upregulation of miR-496 decreases cerebral ischemia/reperfusion injury by negatively regulating BCL2L14.,2019,10.1016/j.neulet.2018.12.039,https://pubmed.ncbi.nlm.nih.gov/30597231/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,31815358,Lidocaine promotes fibroblast proliferation after thermal injury via up-regulating the expression of miR-663 and miR-486.,2020,10.1002/kjm2.12166,https://pubmed.ncbi.nlm.nih.gov/31815358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,37741593,Transcriptome profiling reveals transcriptional regulation of Protegrin-1 on immune defense and development in porcine granulosa cells.,2024,10.1016/j.gene.2023.147819,https://pubmed.ncbi.nlm.nih.gov/37741593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,40232601,Differences in response to immunotherapy drugs including blinatumomab and inotuzumab ozogamicin in B-ALL patients.,2025,10.1007/s12185-025-03983-5,https://pubmed.ncbi.nlm.nih.gov/40232601/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,38984061,Effect of Biomass Torrefaction on the Syngas Quality Produced by Chemical Looping Gasification at 20 kWth Scale.,2024,10.1021/acs.energyfuels.4c01096,https://pubmed.ncbi.nlm.nih.gov/38984061/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,36091478,Influence of an Oxygen Carrier on the CH4 Reforming Reaction Linked to the Biomass Chemical Looping Gasification Process.,2022,10.1021/acs.energyfuels.2c00705,https://pubmed.ncbi.nlm.nih.gov/36091478/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,19524489,Upregulated BclG(L) expression enhances apoptosis of peripheral blood CD4+ T lymphocytes in patients with systemic lupus erythematosus.,2009,10.1016/j.clim.2009.05.010,https://pubmed.ncbi.nlm.nih.gov/19524489/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,26564400,An RNA interference screen identifies new avenues for nephroprotection.,2016,10.1038/cdd.2015.128,https://pubmed.ncbi.nlm.nih.gov/26564400/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,22573796,Multistage analysis of variants in the inflammation pathway and lung cancer risk in smokers.,2012,10.1158/1055-9965.epi-12-0352-t,https://pubmed.ncbi.nlm.nih.gov/22573796/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,16987558,Hyper-activated IRF-1 and STAT1 contribute to enhanced interferon stimulated gene (ISG) expression by interferon alpha and gamma co-treatment in human hepatoma cells.,2006,10.1016/j.bbaexp.2006.08.003,https://pubmed.ncbi.nlm.nih.gov/16987558/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,25213837,Haploinsufficiency of ETV6 and CDKN1B in patients with acute myeloid leukemia and complex karyotype.,2014,10.1186/1471-2164-15-784,https://pubmed.ncbi.nlm.nih.gov/25213837/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,22964015,Arsenic trioxide and ascorbic acid interfere with the BCL2 family genes in patients with myelodysplastic syndromes: an ex-vivo study.,2012,10.1186/1756-8722-5-53,https://pubmed.ncbi.nlm.nih.gov/22964015/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,18465208,Comparison of the effects of 40% oxygen and two atmospheric absolute air pressure conditions on stress-induced premature senescence of normal human diploid fibroblasts.,2008,10.1007/s12192-008-0041-5,https://pubmed.ncbi.nlm.nih.gov/18465208/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BCL2L14,ENSG00000121380,Unsafe,11054413,"Bcl-G, a novel pro-apoptotic member of the Bcl-2 family.",2001,10.1074/jbc.m005889200,https://pubmed.ncbi.nlm.nih.gov/11054413/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,39276259,"Elevated BEAN1 expression correlates with poor prognosis, immune evasion, and chemotherapy resistance in rectal adenocarcinoma.",2024,10.1007/s12672-024-01321-5,https://pubmed.ncbi.nlm.nih.gov/39276259/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,42010774,Risk factors underlying brain structure change rate in cognitive decline: Results from genomewide and phenomewide investigations.,2026,10.1002/alz.71411,https://pubmed.ncbi.nlm.nih.gov/42010774/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,40765612,Non-coding repeat analyses in patients with Parkinson's disease.,2025,10.3389/fneur.2025.1606305,https://pubmed.ncbi.nlm.nih.gov/40765612/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,42806408,Large-scale genetic profiling of hereditary ataxias in China: implications for a stepwise molecular diagnostic strategy.,2026,10.1186/s40035-026-00584-y,https://pubmed.ncbi.nlm.nih.gov/42806408/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,39194536,Hypoxia-Induced Adaptations of Embryonic Fibroblasts: Implications for Developmental Processes.,2024,10.3390/biology13080598,https://pubmed.ncbi.nlm.nih.gov/39194536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,41426430,The role of disease-associated short tandem repeats in amyotrophic lateral sclerosis.,2025,10.1093/braincomms/fcaf482,https://pubmed.ncbi.nlm.nih.gov/41426430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,36319738,Spinocerebellar ataxia type 31 (SCA31).,2023,10.1038/s10038-022-01091-4,https://pubmed.ncbi.nlm.nih.gov/36319738/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,38961870,Tremor-associated short tandem repeat intermediate and pathogenic expansions in familial essential tremor.,2024,10.1093/braincomms/fcae217,https://pubmed.ncbi.nlm.nih.gov/38961870/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,40488180,Diagnostic yield and limitations of whole-genome sequencing for hereditary cerebellar ataxia.,2025,10.1093/braincomms/fcaf188,https://pubmed.ncbi.nlm.nih.gov/40488180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,34113230,Insight Into Spinocerebellar Ataxia Type 31 (SCA31) From Drosophila Model.,2021,10.3389/fnins.2021.648133,https://pubmed.ncbi.nlm.nih.gov/34113230/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,31755042,Molecular Mechanisms and Future Therapeutics for Spinocerebellar Ataxia Type 31 (SCA31).,2019,10.1007/s13311-019-00804-6,https://pubmed.ncbi.nlm.nih.gov/31755042/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,33794121,Identification of the protective effect of Polygonatum sibiricum polysaccharide on d-galactose-induced brain ageing in mice by the systematic characterization of a circular RNA-associated ceRNA network.,2021,10.1080/13880209.2021.1893347,https://pubmed.ncbi.nlm.nih.gov/33794121/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,36092952,ATTCT and ATTCC repeat expansions in the ATXN10 gene affect disease penetrance of spinocerebellar ataxia type 10.,2022,10.1016/j.xhgg.2022.100137,https://pubmed.ncbi.nlm.nih.gov/36092952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,32066831,Long-read sequencing identifies the pathogenic nucleotide repeat expansion in RFC1 in a Japanese case of CANVAS.,2020,10.1038/s10038-020-0733-y,https://pubmed.ncbi.nlm.nih.gov/32066831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,33785066,Midbrain atrophy related to parkinsonism in a non-coding repeat expansion disorder: five cases of spinocerebellar ataxia type 31 with nigrostriatal dopaminergic dysfunction.,2021,10.1186/s40673-021-00134-4,https://pubmed.ncbi.nlm.nih.gov/33785066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,23607545,Abnormal RNA structures (RNA foci) containing a penta-nucleotide repeat (UGGAA)n in the Purkinje cell nucleus is associated with spinocerebellar ataxia type 31 pathogenesis.,2013,10.1111/neup.12032,https://pubmed.ncbi.nlm.nih.gov/23607545/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,24050121,Oestrogen levels in serum and urine of premenopausal women eating low and high amounts of meat.,2014,10.1017/s1368980013002553,https://pubmed.ncbi.nlm.nih.gov/24050121/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,22713773,Urinary estrogen metabolites in two soy trials with premenopausal women.,2012,10.1038/ejcn.2012.71,https://pubmed.ncbi.nlm.nih.gov/22713773/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEAN1,ENSG00000166546,Unsafe,16743087,Investigations on the Nitrogenous Metabolism of the Higher Plants: Part II. The Distribution of Nitrogen in the Leaves of the Runner Bean.,1922,10.1042/bj0160344,https://pubmed.ncbi.nlm.nih.gov/16743087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,42116563,A novel hemizygous missense variant in the BEND2 gene is associated with nonobstructive azoospermia.,2026,10.4103/aja2025122,https://pubmed.ncbi.nlm.nih.gov/42116563/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,40833257,The full-length BEND2 protein is dispensable for spermatogenesis but required for setting the ovarian reserve in mice.,2025,10.7554/elife.96052,https://pubmed.ncbi.nlm.nih.gov/40833257/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,42659417,PSIP1::TBL1X: a recurrent gene fusion in pancreatic neuroendocrine tumors.,2026,10.1530/erc-26-0177,https://pubmed.ncbi.nlm.nih.gov/42659417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,41821381,BEND2 Immunohistochemistry as a Useful Diagnostic Marker for Astroblastomas With BEND2 Fusion.,2026,10.1097/pas.0000000000002529,https://pubmed.ncbi.nlm.nih.gov/41821381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,42120806,Case report of a rare TCF3::BEND2-fused primary intracranial neuroepithelial neoplasm in a female child.,2026,10.1007/s10014-026-00538-2,https://pubmed.ncbi.nlm.nih.gov/42120806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,42368633,Soft-tissue sarcoma with MN1-BEND2 fusion: second reported case and comparative analysis.,2026,10.1093/jscr/rjag481,https://pubmed.ncbi.nlm.nih.gov/42368633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,42043573,A novel BEND2 monoclonal antibody enables highly specific immunohistochemical diagnosis of BEND2-fusion astroblastomas.,2026,10.1007/s00401-026-03023-4,https://pubmed.ncbi.nlm.nih.gov/42043573/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,40784487,Recurrent BEND2 Fusion Genes Identified by Whole Transcriptome Sequencing of Nonfunctional Pancreatic Neuroendocrine Tumors Correlate With Poor Patient Prognosis.,2025,10.1016/j.modpat.2025.100863,https://pubmed.ncbi.nlm.nih.gov/40784487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,42399441,Astroblastoma-like tumor with an EWSR1::BEND2 fusion in the fourth ventricle: a case report and narrative review.,2026,10.1007/s00381-026-07386-7,https://pubmed.ncbi.nlm.nih.gov/42399441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,41794038,Molecular taxonomy of pancreatic neuroendocrine tumors reveals BEND2-fusions-driven transcriptional plasticity and therapeutic vulnerabilities.,2026,10.1016/j.xcrm.2026.102642,https://pubmed.ncbi.nlm.nih.gov/41794038/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,41452469,Expanding the differential diagnosis of bone-forming tumors: a new entity characterized by a NIPBL::BEND2 fusion.,2026,10.1007/s00256-025-05109-8,https://pubmed.ncbi.nlm.nih.gov/41452469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,41102727,EWSR1::BEND2 fusion sarcoma of the urinary bladder - a case report and review of literature.,2025,10.1186/s13000-025-01721-3,https://pubmed.ncbi.nlm.nih.gov/41102727/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,40369078,Oncogenic fusions converge on shared mechanisms in initiating astroblastoma.,2025,10.1038/s41586-025-08981-5,https://pubmed.ncbi.nlm.nih.gov/40369078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,41429568,Molecular and clinical stratification of astroblastomas: Three distinct fusion-defined groups informing risk-adapted treatment strategies.,2026,10.1093/neuonc/noaf283,https://pubmed.ncbi.nlm.nih.gov/41429568/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,42210310,Multi-omic profiles of neuroendocrine neoplasms of the pancreas: an integrated landscape.,2026,10.1186/s12943-026-02697-4,https://pubmed.ncbi.nlm.nih.gov/42210310/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,41114793,A pediatric low-grade sinonasal mesenchymal tumor harboring a novel CHD9::BEND2 fusion.,2025,10.1007/s00428-025-04307-y,https://pubmed.ncbi.nlm.nih.gov/41114793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,41476252,REC8-Cohesin Preferentially Localizes to Promoters of Genes that are Regulated by Transcription Suppressor BEND2 During Early Meiosis.,2025,10.1093/gpbjnl/qzaf138,https://pubmed.ncbi.nlm.nih.gov/41476252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,41466358,A Case of Spinal Astroblastoma-Like Neuroepithelial Tumor With MAMLD1::BEND2 Fusion.,2026,10.1111/pin.70075,https://pubmed.ncbi.nlm.nih.gov/41466358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,41128545,Fenestrating Adenocarcinoma: A Novel Salivary Gland Cancer With EWSR1::BEND2 Fusion and Predilection for the Pharynx.,2026,10.1097/pas.0000000000002475,https://pubmed.ncbi.nlm.nih.gov/41128545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,40597352,Clinical applications of and molecular insights from RNA sequencing in a rare disease cohort.,2025,10.1186/s13073-025-01494-w,https://pubmed.ncbi.nlm.nih.gov/40597352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,38129983,A case of disseminated spinal astroblastoma harboring a MAMLD1::BEND2 fusion.,2024,10.1111/neup.12960,https://pubmed.ncbi.nlm.nih.gov/38129983/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,38339014,Identification of Novel/Rare EWSR1 Fusion Partners in Undifferentiated Mesenchymal Neoplasms.,2024,10.3390/ijms25031735,https://pubmed.ncbi.nlm.nih.gov/38339014/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,36690805,"Gene fusions are frequent in ACTH-secreting neuroendocrine neoplasms of the pancreas, but not in their non-pancreatic counterparts.",2023,10.1007/s00428-022-03484-4,https://pubmed.ncbi.nlm.nih.gov/36690805/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,32124419,Salivary Gland Cancer in the Era of Routine Next-Generation Sequencing.,2020,10.1007/s12105-020-01140-4,https://pubmed.ncbi.nlm.nih.gov/32124419/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,30665415,miRNAs and target genes in the blood as biomarkers for the early diagnosis of Parkinson's disease.,2019,10.1186/s12918-019-0680-4,https://pubmed.ncbi.nlm.nih.gov/30665415/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND2,ENSG00000177324,Unsafe,16291514,Expression of heme oxygenase-1 protects endothelial cells from irradiation-induced apoptosis.,2005,10.1080/10623320500189814,https://pubmed.ncbi.nlm.nih.gov/16291514/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,41497890,Integrated Pan-Cancer Profiling and Breast Cancer Validation Identify BEND3 as a Potential Prognostic and Immune Biomarker.,2025,10.2147/bctt.s553681,https://pubmed.ncbi.nlm.nih.gov/41497890/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,42462897,β-Hydroxybutyrate induces histone H3 β-hydroxybutyrylation and attenuates diabetic brain microvascular endothelial hyperpermeability.,2026,10.1016/j.expneurol.2026.115905,https://pubmed.ncbi.nlm.nih.gov/42462897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,40158797,BEND3 promotes hepatocellular carcinoma progression and metastasis by activating the PI3K/AKT/mTOR pathway and inducing epithelial-mesenchymal transition.,2025,10.1016/j.clinre.2025.102582,https://pubmed.ncbi.nlm.nih.gov/40158797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,39717669,Exosomes from IH- Induced bEnd3 Cells Promote OSA Cognitive Impairment via miR-20a-5p/MFN2 Mediated Pyroptosis of HT22 Cells.,2024,10.2147/nss.s485952,https://pubmed.ncbi.nlm.nih.gov/39717669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,41185023,Metformin's protection against blood-brain barrier disruption and neuronal dysfunction under oxygen-glucose deprivation and tobacco smoke and e-vape chemical exposure.,2025,10.1186/s12987-025-00719-9,https://pubmed.ncbi.nlm.nih.gov/41185023/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,42600269,CCL2 knockdown attenuates post-traumatic external cerebral herniation by suppressing JAK-STAT signaling following traumatic brain injury.,2026,10.1016/j.intimp.2026.117212,https://pubmed.ncbi.nlm.nih.gov/42600269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,39516720,Exosomes activate hippocampal microglia in atrial fibrillation through long-distance heart-brain communication.,2024,10.1186/s12872-024-04274-3,https://pubmed.ncbi.nlm.nih.gov/39516720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,41471062,3D-Printed Oral Disintegrating Films of Brain-Targeted Acetyl Salicylic Acid Nanoparticles for Enhanced CNS Delivery in Ischemic Stroke.,2025,10.3390/pharmaceutics17121547,https://pubmed.ncbi.nlm.nih.gov/41471062/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,39207064,Glycine Receptor Beta Subunit (GlyR-β) Promotes Potential Angiogenesis and Neurological Regeneration during Early-Stage Recovery after Cerebral Ischemia Stroke/Reperfusion in Mice.,2024,10.31083/j.jin2308145,https://pubmed.ncbi.nlm.nih.gov/39207064/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,39305744,Ginsenoside Rg2 alleviates astrocyte inflammation and ameliorates the permeability of the Alzheimer's disease related blood-brain barrier.,2024,10.1016/j.phymed.2024.156063,https://pubmed.ncbi.nlm.nih.gov/39305744/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,37509346,Role of Transcription Factor BEND3 and Its Potential Effect on Cancer Progression.,2023,10.3390/cancers15143685,https://pubmed.ncbi.nlm.nih.gov/37509346/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,38657460,Study on the role of CCM3 gene and lead exposure induced neurotoxicity through neurovascular units.,2024,10.1016/j.ecoenv.2024.116269,https://pubmed.ncbi.nlm.nih.gov/38657460/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,38897539,The protective effects of Axitinib on blood-brain barrier dysfunction and ischemia-reperfusion injury in acute ischemic stroke.,2024,10.1016/j.expneurol.2024.114870,https://pubmed.ncbi.nlm.nih.gov/38897539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,40074037,Phosphatidylcholine synthesis and remodeling in brain endothelial cells.,2025,10.1016/j.jlr.2025.100773,https://pubmed.ncbi.nlm.nih.gov/40074037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,37650637,A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation.,2023,10.1093/nar/gkad719,https://pubmed.ncbi.nlm.nih.gov/37650637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,37194980,BENDing with Polycomb in pluripotency and cancer.,2023,10.1002/bies.202300046,https://pubmed.ncbi.nlm.nih.gov/37194980/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,39700966,Intranasal delivery of mesenchymal stem cell-derived exosomes ameliorates experimental autoimmune encephalomyelitis.,2025,10.1016/j.intimp.2024.113853,https://pubmed.ncbi.nlm.nih.gov/39700966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,36882451,CD24-associated ceRNA network reveals prognostic biomarkers in breast carcinoma.,2023,10.1038/s41598-022-25072-x,https://pubmed.ncbi.nlm.nih.gov/36882451/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,35217604,BEND3 safeguards pluripotency by repressing differentiation-associated genes.,2022,10.1073/pnas.2107406119,https://pubmed.ncbi.nlm.nih.gov/35217604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,40652849,The liquid crystal monomer EtCBN induced neurotoxicity by activating the NOD-like receptor signaling pathway through the Muribaculum-epigallocatechin axis.,2025,10.1016/j.jhazmat.2025.139206,https://pubmed.ncbi.nlm.nih.gov/40652849/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,37107353,New Indole-3-Propionic Acid and 5-Methoxy-Indole Carboxylic Acid Derived Hydrazone Hybrids as Multifunctional Neuroprotectors.,2023,10.3390/antiox12040977,https://pubmed.ncbi.nlm.nih.gov/37107353/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,38385532,Bivalent chromatin: a developmental balancing act tipped in cancer.,2024,10.1042/bst20230426,https://pubmed.ncbi.nlm.nih.gov/38385532/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,33476303,A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity.,2021,10.1172/jci.insight.141518,https://pubmed.ncbi.nlm.nih.gov/33476303/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,35138974,Proteome-wide analysis reveals molecular pathways affected by AgNP in a ROS-dependent manner.,2022,10.1080/17435390.2022.2036844,https://pubmed.ncbi.nlm.nih.gov/35138974/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,33855696,Hydrogen sulfide prevents ethanol-induced ZO-1 CpG promoter hypermethylation-dependent vascular permeability via miR-218/DNMT3a axis.,2021,10.1002/jcp.30382,https://pubmed.ncbi.nlm.nih.gov/33855696/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,29360423,Efficacy for lung metastasis induced by the allogeneic bEnd3 vaccine in mice.,2018,10.1080/21645515.2018.1427532,https://pubmed.ncbi.nlm.nih.gov/29360423/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,36979746,Knocking-Down CD147/EMMPRIN Expression in CT26 Colon Carcinoma Forces the Cells into Cellular and Angiogenic Dormancy That Can Be Reversed by Interactions with Macrophages.,2023,10.3390/biomedicines11030768,https://pubmed.ncbi.nlm.nih.gov/36979746/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,34393764,Effects of Lipotoxicity in Brain Microvascular Endothelial Cells During Sirt3 Deficiency-Potential Role in Comorbid Alzheimer's Disease.,2021,10.3389/fnagi.2021.716616,https://pubmed.ncbi.nlm.nih.gov/34393764/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,33498250,Ubiquinol Supplementation Improves Gender-Dependent Cerebral Vasoreactivity and Ameliorates Chronic Inflammation and Endothelial Dysfunction in Patients with Mild Cognitive Impairment.,2021,10.3390/antiox10020143,https://pubmed.ncbi.nlm.nih.gov/33498250/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,32172875,Engineering butylglyceryl-modified polysaccharides towards nanomedicines for brain drug delivery.,2020,10.1016/j.carbpol.2020.116060,https://pubmed.ncbi.nlm.nih.gov/32172875/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,27392852,High-Throughput Screening for Identification of Blood-Brain Barrier Integrity Enhancers: A Drug Repurposing Opportunity to Rectify Vascular Amyloid Toxicity.,2016,10.3233/jad-151179,https://pubmed.ncbi.nlm.nih.gov/27392852/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,34831473,Dose and Dose Rate-Dependent Effects of Low-Dose Irradiation on Inflammatory Parameters in ApoE-Deficient and Wild Type Mice.,2021,10.3390/cells10113251,https://pubmed.ncbi.nlm.nih.gov/34831473/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,25400923,Human T cells expressing BEND3 on their surface represent a novel subpopulation that preferentially produces IL-6 and IL-8.,2014,10.1002/iid3.17,https://pubmed.ncbi.nlm.nih.gov/25400923/,annotation citations | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND3,ENSG00000178409,Unsafe,21914818,A BEN-domain-containing protein associates with heterochromatin and represses transcription.,2011,10.1242/jcs.086603,https://pubmed.ncbi.nlm.nih.gov/21914818/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND4,ENSG00000188848,Unsafe,42251161,Discovery of BEND4 as a novel single-gene prognostic marker and therapeutic target for adverse AML.,2026,10.1038/s41698-026-01534-7,https://pubmed.ncbi.nlm.nih.gov/42251161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND4,ENSG00000188848,Unsafe,40327257,BEND4: a novel prognostic biomarker in diffuse large B-cell lymphoma.,2025,10.1007/s12672-025-02519-x,https://pubmed.ncbi.nlm.nih.gov/40327257/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND4,ENSG00000188848,Unsafe,38926248,"Epigenetic silencing of BEND4, a novel DNA damage repair gene, is a synthetic lethal marker for ATM inhibitor in pancreatic cancer.",2024,10.1007/s11684-023-1053-3,https://pubmed.ncbi.nlm.nih.gov/38926248/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND4,ENSG00000188848,Unsafe,35221871,BEND4 as a Candidate Gene for an Infection-Induced Acute Encephalopathy Characterized by a Cyst and Calcification of the Pons and Cerebellar Atrophy.,2022,10.1159/000517541,https://pubmed.ncbi.nlm.nih.gov/35221871/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND4,ENSG00000188848,Unsafe,34731408,Bend family proteins mark chromatin boundaries and synergistically promote early germ cell differentiation.,2022,10.1007/s13238-021-00884-1,https://pubmed.ncbi.nlm.nih.gov/34731408/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND4,ENSG00000188848,Unsafe,34527169,MicroRNA Dysregulation in the Hippocampus of Rats with Noise-Induced Hearing Loss.,2021,10.1155/2021/1377195,https://pubmed.ncbi.nlm.nih.gov/34527169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND4,ENSG00000188848,Unsafe,35117820,Identification of hub genes correlated with the pathogenesis and prognosis in Pancreatic adenocarcinoma on bioinformatics methods.,2020,10.21037/tcr-19-2873,https://pubmed.ncbi.nlm.nih.gov/35117820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND4,ENSG00000188848,Unsafe,37685003,Genome-Wide Association Study to Identify QTL for Carcass Traits in Korean Hanwoo Cattle.,2023,10.3390/ani13172737,https://pubmed.ncbi.nlm.nih.gov/37685003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND4,ENSG00000188848,Unsafe,32099098,"Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium.",2020,10.1038/s41380-020-0677-9,https://pubmed.ncbi.nlm.nih.gov/32099098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND4,ENSG00000188848,Unsafe,28722770,Asbestos-associated genome-wide DNA methylation changes in lung cancer.,2017,10.1002/ijc.30897,https://pubmed.ncbi.nlm.nih.gov/28722770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND4,ENSG00000188848,Unsafe,30070359,Discovery and development of differentially methylated regions in human papillomavirus-related oropharyngeal squamous cell carcinoma.,2018,10.1002/ijc.31778,https://pubmed.ncbi.nlm.nih.gov/30070359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND4,ENSG00000188848,Unsafe,21636702,Novel candidate colorectal cancer biomarkers identified by methylation microarray-based scanning.,2011,10.1530/erc-11-0083,https://pubmed.ncbi.nlm.nih.gov/21636702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BEND4,ENSG00000188848,Unsafe,18453221,[Selection of genes related to multidrug resistance of pancreatic ductal adenocarcinoma by microarray analysis].,2007,,https://pubmed.ncbi.nlm.nih.gov/18453221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,42460258,Prognostic Relevance of Neddylation-Related Genes in Hepatocellular Carcinoma.,2026,10.2147/jhc.s610030,https://pubmed.ncbi.nlm.nih.gov/42460258/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,42908879,Whole genome sequencing identifies genetic variants associated with senescence-accelerated phenotype of OXYS rats.,2026,10.18699/vjgb-26-90,https://pubmed.ncbi.nlm.nih.gov/42908879/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,41470198,Multi-Omics and Functional Analysis of BFSP1 as a Prognostic and Therapeutic Target in Liver Hepatocellular Carcinoma.,2025,10.3390/medicina61122196,https://pubmed.ncbi.nlm.nih.gov/41470198/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,40097750,M6A-modified BFSP1 induces aerobic glycolysis to promote liver cancer growth and metastasis through upregulating tropomodulin 4.,2025,10.1186/s43556-025-00256-9,https://pubmed.ncbi.nlm.nih.gov/40097750/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,40349178,Intermediate Filament Protein BFSP1 Maintains Oocyte Asymmetric Division by Modulating Spindle Length.,2025,10.1002/advs.202504066,https://pubmed.ncbi.nlm.nih.gov/40349178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,39732836,Bioinformatics identifies key genes and potential therapeutic targets in the pathological mechanism of oxidative stress in Randall's plaque.,2024,10.1038/s41598-024-82849-y,https://pubmed.ncbi.nlm.nih.gov/39732836/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,42195049,Stage-Specific Expression of Lens-Associated Structural Genes During Early Embryogenesis in European Seabass (&lt;i&gt;Dicentrarchus labrax&lt;/i&gt;).,2026,10.3390/genes17050590,https://pubmed.ncbi.nlm.nih.gov/42195049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,37667037,D348N Mutation of BFSP1 Gene in Congenital Cataract: it Does Matter.,2023,10.1007/s12013-023-01169-6,https://pubmed.ncbi.nlm.nih.gov/37667037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,37371051,Independent Membrane Binding Properties of the Caspase Generated Fragments of the Beaded Filament Structural Protein 1 (BFSP1) Involves an Amphipathic Helix.,2023,10.3390/cells12121580,https://pubmed.ncbi.nlm.nih.gov/37371051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,40997594,WGCNA-based integration of transcriptomics and metabolomics reveals key meat quality regulators during development in Jingyuan chickens.,2025,10.1016/j.psj.2025.105843,https://pubmed.ncbi.nlm.nih.gov/40997594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,38650819,Lens Cytoskeleton: An Update on the Etiopathogenesis of Human Cataracts.,2024,10.7759/cureus.56793,https://pubmed.ncbi.nlm.nih.gov/38650819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,36359912,Generation of Lens Progenitor Cells and Lentoid Bodies from Pluripotent Stem Cells: Novel Tools for Human Lens Development and Ocular Disease Etiology.,2022,10.3390/cells11213516,https://pubmed.ncbi.nlm.nih.gov/36359912/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,34995847,Generation of an induced pluripotent stem cell line (SYSUSCi001-A) from a congenital cataract patient carrying heterozygous mutations in BFSP1 and RHO.,2022,10.1016/j.scr.2021.102644,https://pubmed.ncbi.nlm.nih.gov/34995847/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,35813324,The miRNA-34a/Sirt1/p53 pathway in a rat model of lens regeneration.,2022,10.21037/atm-22-2099,https://pubmed.ncbi.nlm.nih.gov/35813324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,36861063,A PTEN-Autophagy Risk Model for the Prediction of Prognosis and Immune Microenvironment in Hepatocellular Carcinoma.,2023,10.1155/2023/2973480,https://pubmed.ncbi.nlm.nih.gov/36861063/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,37048143,High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology.,2023,10.3390/cells12071070,https://pubmed.ncbi.nlm.nih.gov/37048143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,36161833,Pathogenic genetic variants identified in Australian families with paediatric cataract.,2022,10.1136/bmjophth-2022-001064,https://pubmed.ncbi.nlm.nih.gov/36161833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,36698218,"Dynamic changes in whole genome DNA methylation, chromatin and gene expression during mouse lens differentiation.",2023,10.1186/s13072-023-00478-7,https://pubmed.ncbi.nlm.nih.gov/36698218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,30790544,BFSP1 C-terminal domains released by post-translational processing events can alter significantly the calcium regulation of AQP0 water permeability.,2019,10.1016/j.exer.2019.02.001,https://pubmed.ncbi.nlm.nih.gov/30790544/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,36457707,Exploring a four-gene risk model based on doxorubicin resistance-associated lncRNAs in hepatocellular carcinoma.,2022,10.3389/fphar.2022.1015842,https://pubmed.ncbi.nlm.nih.gov/36457707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,33407546,Model based on five tumour immune microenvironment-related genes for predicting hepatocellular carcinoma immunotherapy outcomes.,2021,10.1186/s12967-020-02691-4,https://pubmed.ncbi.nlm.nih.gov/33407546/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,31136738,Lens differentiation is characterized by stage-specific changes in chromatin accessibility correlating with differentiation state-specific gene expression.,2019,10.1016/j.ydbio.2019.04.020,https://pubmed.ncbi.nlm.nih.gov/31136738/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,27559293,Expression of the type VI intermediate filament proteins CP49 and filensin in the mouse lens epithelium.,2016,,https://pubmed.ncbi.nlm.nih.gov/27559293/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,22669729,A missense mutation in CRYGD linked with autosomal dominant congenital cataract of aculeiform type.,2012,10.1007/s11010-012-1355-2,https://pubmed.ncbi.nlm.nih.gov/22669729/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BFSP1,ENSG00000125864,Unsafe,7720401,Chromosomal locations of the genes for the beaded filament proteins CP 115 and CP 47.,1995,10.3109/02713689508999909,https://pubmed.ncbi.nlm.nih.gov/7720401/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42547568,Super-enhancer landscape regulated by CDK12 drives retinoblastoma progression.,2026,10.1038/s41416-026-03563-2,https://pubmed.ncbi.nlm.nih.gov/42547568/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42695422,Follicular Fluid Exosomes From Diminished Ovarian Reserve Patients Impair Granulosa Cell Function via miR-135a-5p-Mediated Suppression of BIRC5.,2026,10.1002/mrd.70143,https://pubmed.ncbi.nlm.nih.gov/42695422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42445845,Baculoviral Inhibitor of Apoptosis Repeat Containing 5 (BIRC5) Regulates Cancer Stem Cell Properties and Epithelial-Mesenchymal Transition in Human Breast Cancer Cells.,2026,10.12717/dr.2026.30.2.95,https://pubmed.ncbi.nlm.nih.gov/42445845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42255235,BIRC5 drives cell-cycle dysregulation and represents a novel molecular target in retinoblastoma.,2026,10.3389/fonc.2026.1854143,https://pubmed.ncbi.nlm.nih.gov/42255235/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42088395,&lt;i&gt;BIRC5&lt;/i&gt; Promoter-Driven Nanodrugs Suppress BIRC5-Positive Cancers Independent of ABCB1 Status and IDO1 Expression.,2026,10.2147/ijn.s588571,https://pubmed.ncbi.nlm.nih.gov/42088395/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42056221,BIRC5 modulates keratinocyte proliferation and apoptosis via PI3K/AKT/mTOR-mediated autophagy.,2026,10.1038/s41598-026-51093-x,https://pubmed.ncbi.nlm.nih.gov/42056221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42787653,Role of hypoxia-inducible factor - 1 alpha on the progression of cervical intraepithelial neoplasia and cervical cancer: a narrative review.,2026,10.3389/fonc.2026.1922814,https://pubmed.ncbi.nlm.nih.gov/42787653/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,41838306,Identified BIRC5 and HDAC1 as novel diagnostic biomarkers linked to centrosome-immune crosstalk for cutaneous squamous cell carcinoma via machine learning-based multi-omics analysis.,2026,10.1007/s12672-026-04547-7,https://pubmed.ncbi.nlm.nih.gov/41838306/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,41361777,Comprehensive analysis of BIRC5: from pan-cancer analysis to experimental validation.,2025,10.1186/s12885-025-15184-8,https://pubmed.ncbi.nlm.nih.gov/41361777/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,41372715,From bioinformatics to clinical translation: BIRC5 as a pivotal diagnostic biomarker and therapeutic target for NAFLD-driven HCC.,2025,10.1007/s10565-025-10128-1,https://pubmed.ncbi.nlm.nih.gov/41372715/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42696959,A chemoresistance-associated proliferation gene signature identified by single-cell and machine learning analysis predicts prognosis in high-grade serous ovarian carcinoma.,2026,10.1016/j.tranon.2026.103018,https://pubmed.ncbi.nlm.nih.gov/42696959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,39999831,BIRC5 Is a Potential Biomarker Associated with Immune System Infiltration in Glioma.,2025,10.3340/jkns.2024.0106,https://pubmed.ncbi.nlm.nih.gov/39999831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42451651,Survivin-Targeting Antisense Oligonucleotides in Cancer Therapy.,2026,10.3390/molecules31132283,https://pubmed.ncbi.nlm.nih.gov/42451651/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42120197,Combined Chitosan and Ivy Leaf Extract Mitigate Deltamethrin-Induced Hepatorenal and Reproductive Toxicity via miR-144 Antioxidant Signaling.,2026,10.1002/tox.70118,https://pubmed.ncbi.nlm.nih.gov/42120197/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42766934,YAP1 inhibition delays the progression of posterior capsular opacification through attenuation of lens epithelial-mesenchymal transition.,2026,10.1016/j.tice.2026.103973,https://pubmed.ncbi.nlm.nih.gov/42766934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42638483,Survivin drives renal cell carcinoma tumorigenesis via proliferative and metabolic adaptation.,2026,10.1242/dmm.052706,https://pubmed.ncbi.nlm.nih.gov/42638483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42025078,Bioinformatics and experimental insights into LINC01605 and the miR-101-3p/BIRC5 axis in oral squamous cell carcinoma pathogenesis and clinical outcomes.,2026,10.1016/j.ctarc.2026.101212,https://pubmed.ncbi.nlm.nih.gov/42025078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,40950902,BIRC5 expression correlates with immunosuppressive phenotype and predicts inferior response to immunotherapy in lung adenocarcinoma.,2025,10.21037/jtd-2025-216,https://pubmed.ncbi.nlm.nih.gov/40950902/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42726806,Identification of functional genes and immune cell infiltration analysis in liposarcoma.,2026,10.1371/journal.pone.0358180,https://pubmed.ncbi.nlm.nih.gov/42726806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42692182,Influence of riboflavin-UV-A illumination on the expression of pro- and anti-apoptotic markers in human corneal fibroblasts from healthy and keratoconus corneas.,2026,10.1016/j.exer.2026.111227,https://pubmed.ncbi.nlm.nih.gov/42692182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42410253,OncoMimic peptide-based immunotherapy EO2401 induces shared T cell clusters in patients with adrenal cancer.,2026,10.1038/s43856-026-01755-8,https://pubmed.ncbi.nlm.nih.gov/42410253/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,41948103,Comprehensive Analysis Based on the Cancer-Immunity Cycle Identifies a Novel Immunosuppressive Subtype of Bladder Cancer.,2026,10.1155/ijog/9720283,https://pubmed.ncbi.nlm.nih.gov/41948103/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42797409,Artificial Intelligence-Guided Prioritization and Experimental Evaluation of Synergistic Target Combinations for Breast Cancer Therapy.,2026,10.3390/ph19091363,https://pubmed.ncbi.nlm.nih.gov/42797409/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,41925746,Integrated spatial transcriptomics and pan-cancer XGBoost modeling uncover spatial drivers of immune exclusion and predict immunotherapy response.,2026,10.1007/s00262-026-04374-3,https://pubmed.ncbi.nlm.nih.gov/41925746/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42343319,Epigenetic collapse establishes transcriptional bottlenecks in malignant rhabdoid tumor.,2026,10.1186/s13148-026-02170-5,https://pubmed.ncbi.nlm.nih.gov/42343319/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,39698582,Identification of BIRC5 and HMMR as prognostic biomarkers for immune infiltration in prostate cancer.,2024,10.21037/tau-24-359,https://pubmed.ncbi.nlm.nih.gov/39698582/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,40009266,Exploring BIRC family genes as prognostic biomarkers and therapeutic targets in prostate cancer.,2025,10.1007/s12672-025-02002-7,https://pubmed.ncbi.nlm.nih.gov/40009266/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,41056367,In-silico identification of host-key-genes associated with dengue-virus-infections highlighting their pathogenetic mechanisms and therapeutic agents.,2025,10.1371/journal.pone.0333509,https://pubmed.ncbi.nlm.nih.gov/41056367/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,41594586,Design of Anti-Tumor RNA Nanoparticles and Their Inhibitory Effect on Hep3B Liver Cancer.,2025,10.3390/biom16010045,https://pubmed.ncbi.nlm.nih.gov/41594586/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,42314223,Response of MRC-5 human lung fibroblasts to FLASH and conventional radiotherapy: A study on differential DNA damage and transcriptomic response.,2026,10.1016/j.compbiolchem.2026.109198,https://pubmed.ncbi.nlm.nih.gov/42314223/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,40778544,"Unraveling the dual role of METTL3-mediated m&lt;sup&gt;6&lt;/sup&gt;A RNA modification in bladder cancer: mechanisms, therapeutic vulnerabilities, and clinical implications.",2025,10.1080/15384047.2025.2545057,https://pubmed.ncbi.nlm.nih.gov/40778544/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,20627126,Expression analysis suggests a potential cytoprotective role of Birc5 in the inner ear.,2010,10.1016/j.mcn.2010.07.003,https://pubmed.ncbi.nlm.nih.gov/20627126/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,21364656,An otoprotective role for the apoptosis inhibitor protein survivin.,2010,10.1038/cddis.2010.25,https://pubmed.ncbi.nlm.nih.gov/21364656/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,16329164,Molecular cloning and bioinformatics analysis of a novel spliced variant of survivin from human breast cancer cells.,2005,10.1080/10425170500226490,https://pubmed.ncbi.nlm.nih.gov/16329164/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,14741722,Identification of a novel splice variant of the human anti-apoptopsis gene survivin.,2004,10.1016/j.bbrc.2003.12.178,https://pubmed.ncbi.nlm.nih.gov/14741722/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BIRC5,ENSG00000089685,Unsafe,10626797,Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties.,1999,,https://pubmed.ncbi.nlm.nih.gov/10626797/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLOC1S3,ENSG00000189114,Unsafe,38840221,ZNPs reduce epidermal mechanical strain resistance by promoting desmosomal cadherin endocytosis via mTORC1-TFEB-BLOC1S3 axis.,2024,10.1186/s12951-024-02519-z,https://pubmed.ncbi.nlm.nih.gov/38840221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLOC1S3,ENSG00000189114,Unsafe,40413298,Identification of circulating tumor cells marker genes as prognostic signature in triple-negative breast cancer.,2025,10.1007/s12672-025-02604-1,https://pubmed.ncbi.nlm.nih.gov/40413298/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLOC1S3,ENSG00000189114,Unsafe,35299749,Identification of a Novel Tumor Microenvironment Prognostic Signature for Bladder Urothelial Carcinoma.,2022,10.3389/fonc.2022.818860,https://pubmed.ncbi.nlm.nih.gov/35299749/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLOC1S3,ENSG00000189114,Unsafe,34095229,Development and Validation of a 7-Gene Prognostic Signature to Improve Survival Prediction in Pancreatic Ductal Adenocarcinoma.,2021,10.3389/fmolb.2021.676291,https://pubmed.ncbi.nlm.nih.gov/34095229/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLOC1S3,ENSG00000189114,Unsafe,31882470,Detection of Serum miRNAs Affecting Liver Apoptosis in a Periodontitis Rat Model.,2020,10.21873/invivo.11752,https://pubmed.ncbi.nlm.nih.gov/31882470/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLOC1S3,ENSG00000189114,Unsafe,35488210,NGS-based targeted sequencing identified two novel variants in Southwestern Chinese families with oculocutaneous albinism.,2022,10.1186/s12864-022-08597-3,https://pubmed.ncbi.nlm.nih.gov/35488210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLOC1S3,ENSG00000189114,Unsafe,22709368,A BLOC-1 mutation screen reveals a novel BLOC1S3 mutation in Hermansky-Pudlak Syndrome type 8.,2012,10.1111/j.1755-148x.2012.01029.x,https://pubmed.ncbi.nlm.nih.gov/22709368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLOC1S3,ENSG00000189114,Unsafe,30852186,"Comparative transcriptome analysis reveals expression signatures of albino Russian sturgeon, Acipenseriformes gueldenstaedtii.",2019,10.1016/j.margen.2019.02.004,https://pubmed.ncbi.nlm.nih.gov/30852186/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLOC1S3,ENSG00000189114,Unsafe,16385460,A germline mutation in BLOC1S3/reduced pigmentation causes a novel variant of Hermansky-Pudlak syndrome (HPS8).,2006,10.1086/499338,https://pubmed.ncbi.nlm.nih.gov/16385460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLOC1S3,ENSG00000189114,Unsafe,20015953,Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency.,2010,10.1093/hmg/ddp555,https://pubmed.ncbi.nlm.nih.gov/20015953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLOC1S3,ENSG00000189114,Unsafe,31619213,Novel genetic variant of HPS1 gene in Hermansky-Pudlak syndrome with fulminant progression of pulmonary fibrosis: a case report.,2019,10.1186/s12890-019-0941-4,https://pubmed.ncbi.nlm.nih.gov/31619213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLOC1S3,ENSG00000189114,Unsafe,22203680,Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1).,2012,10.1074/jbc.m111.325746,https://pubmed.ncbi.nlm.nih.gov/22203680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLOC1S3,ENSG00000189114,Unsafe,15102850,"Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1).",2004,10.1074/jbc.m402513200,https://pubmed.ncbi.nlm.nih.gov/15102850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLOC1S3,ENSG00000189114,Unsafe,22381399,Lack of association between rs597668 polymorphism near EXOC3L2 and late-onset Alzheimer's disease in Han Chinese.,2012,10.1016/j.neulet.2012.02.030,https://pubmed.ncbi.nlm.nih.gov/22381399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLOC1S3,ENSG00000189114,Unsafe,17618940,Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility.,2008,10.1016/j.biopsych.2006.12.025,https://pubmed.ncbi.nlm.nih.gov/17618940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLOC1S3,ENSG00000189114,Unsafe,18552348,"Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii.",2009,10.1093/schbul/sbn054,https://pubmed.ncbi.nlm.nih.gov/18552348/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLOC1S3,ENSG00000189114,Unsafe,21321396,Replication of BIN1 association with Alzheimer's disease and evaluation of genetic interactions.,2011,10.3233/jad-2011-101932,https://pubmed.ncbi.nlm.nih.gov/21321396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLOC1S3,ENSG00000189114,Unsafe,20460622,Genome-wide analysis of genetic loci associated with Alzheimer disease.,2010,10.1001/jama.2010.574,https://pubmed.ncbi.nlm.nih.gov/20460622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,40973493,Bltp1 Is Required for Survival and Normal Development and Function of the Neuromuscular Junction in Mice.,2025,10.1523/jneurosci.0029-25.2025,https://pubmed.ncbi.nlm.nih.gov/40973493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,41898830,Correlation Analysis of &lt;i&gt;BLTP1&lt;/i&gt; (&lt;i&gt;KIAA1109&lt;/i&gt;) and &lt;i&gt;KIF27&lt;/i&gt; Gene Polymorphisms with Wool Traits in Subo Merino Sheep.,2026,10.3390/genes17030295,https://pubmed.ncbi.nlm.nih.gov/41898830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,42381180,Prenatal Diagnosis of Recurrent Alkuraya-Kučinskas Syndrome: A Rare Case Report.,2026,10.1002/jcu.70315,https://pubmed.ncbi.nlm.nih.gov/42381180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,42607524,Identification of a three-gene prognostic signature associated with tumor immune characteristics in lung adenocarcinoma: A comprehensive analysis of multi-omics data.,2026,10.1016/j.tranon.2026.102970,https://pubmed.ncbi.nlm.nih.gov/42607524/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,39228063,Prenatal Phenotype of Alkuraya-Kučinskas Syndrome: A Novel Case and Systematic Literature Review.,2024,10.1002/pd.6637,https://pubmed.ncbi.nlm.nih.gov/39228063/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,40356703,"VPS13 and bridge-like lipid transporters, mechanisms, and mysteries.",2025,10.3389/fnins.2025.1534061,https://pubmed.ncbi.nlm.nih.gov/40356703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,40182349,"The First Known Case Report of a Novel Homozygous Nonsense Variant in the OSBPL9 Gene Associated With Fetal Cerebral Ventriculomegaly, Cerebellar Hypoplasia, and Arthrogryposis Multiplex.",2025,10.7759/cureus.80010,https://pubmed.ncbi.nlm.nih.gov/40182349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,35015055,Vps13-like proteins provide phosphatidylethanolamine for GPI anchor synthesis in the ER.,2022,10.1083/jcb.202111095,https://pubmed.ncbi.nlm.nih.gov/35015055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,38199515,Transcriptome analysis identifies genetic risk markers and explores the pathogenesis for inflammatory bowel disease.,2024,10.1016/j.bbadis.2023.167013,https://pubmed.ncbi.nlm.nih.gov/38199515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,40206966,Recurrent First-trimester Cystic Hygroma with Normal Chromosomes Identified in Two Cases with a Recessive Genetic Syndrome.,2025,10.4103/jmu.jmu_128_23,https://pubmed.ncbi.nlm.nih.gov/40206966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,30906834,Endosomal trafficking defects in patient cells with KIAA1109 biallelic variants.,2019,10.1016/j.gendis.2018.12.004,https://pubmed.ncbi.nlm.nih.gov/30906834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,37455813,Bridge-Like Lipid Transfer Proteins (BLTPs) in C. elegans: From Genetics to Structures and Functions.,2023,10.1177/25152564231186489,https://pubmed.ncbi.nlm.nih.gov/37455813/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,38015522,Identification of potential diagnostic biomarkers and immune infiltration features in diabetic foot ulcer by bioinformatics analysis and validation.,2023,10.14715/cmb/2023.69.11.27,https://pubmed.ncbi.nlm.nih.gov/38015522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,37667381,Transcriptome-wide association study identifies new susceptibility genes and pathways for spondyloarthritis.,2023,10.1186/s13018-023-04029-4,https://pubmed.ncbi.nlm.nih.gov/37667381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,32657846,Two novel pathogenic variants in KIAA1109 causing Alkuraya-Kučinskas syndrome in two Czech Roma brothers.,2020,10.1097/mcd.0000000000000335,https://pubmed.ncbi.nlm.nih.gov/32657846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,32590954,KIAA1109 gene mutation in surviving patients with Alkuraya-Kučinskas syndrome: a review of literature.,2020,10.1186/s12881-020-01074-2,https://pubmed.ncbi.nlm.nih.gov/32590954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,35311058,Compound Heterozygous Variants in a Surviving Patient With Alkuraya-Kučinskas Syndrome: A New Case Report and a Review of the Literature.,2022,10.3389/fped.2022.806752,https://pubmed.ncbi.nlm.nih.gov/35311058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,36357390,A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience.,2022,10.1038/s41467-022-34450-y,https://pubmed.ncbi.nlm.nih.gov/36357390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,36571082,"Sequence Analysis and Structural Predictions of Lipid Transfer Bridges in the Repeating Beta Groove (RBG) Superfamily Reveal Past and Present Domain Variations Affecting Form, Function and Interactions of VPS13, ATG2, SHIP164, Hobbit and Tweek.",2022,10.1177/25152564221134328,https://pubmed.ncbi.nlm.nih.gov/36571082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,33987247,Potential functional variants of KIAA genes are associated with breast cancer risk in a case control study.,2021,10.21037/atm-20-6108,https://pubmed.ncbi.nlm.nih.gov/33987247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,42624826,High Diagnosis Rate for Nonimmune Hydrops Fetalis With Prenatal Clinical Genome: Expanded Results From the Hydrops-Yielding Diagnostic Results of Prenatal Sequencing (HYDROPS) Study.,2026,10.1002/ajmg.a.70265,https://pubmed.ncbi.nlm.nih.gov/42624826/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,31787999,"Mutations in KIAA1109, CACNA1C, BSN, AKAP13, CELSR2, and HELZ2 Are Associated With the Prognosis in Endometrial Cancer.",2019,10.3389/fgene.2019.00909,https://pubmed.ncbi.nlm.nih.gov/31787999/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,22876110,Complement factor H and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis.,2012,,https://pubmed.ncbi.nlm.nih.gov/22876110/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,33859359,Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.,2021,10.1038/s41380-021-01087-0,https://pubmed.ncbi.nlm.nih.gov/33859359/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,31540829,Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen.,2019,10.1016/j.chom.2019.08.017,https://pubmed.ncbi.nlm.nih.gov/31540829/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,22065918,CFH 184G as a genetic risk marker for anterior uveitis in Chinese females.,2011,,https://pubmed.ncbi.nlm.nih.gov/22065918/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,20553587,Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance.,2010,10.1186/ar3053,https://pubmed.ncbi.nlm.nih.gov/20553587/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,21760890,Potential celiac patients: a model of celiac disease pathogenesis.,2011,10.1371/journal.pone.0021281,https://pubmed.ncbi.nlm.nih.gov/21760890/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,30552067,Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.,2019,10.1016/s2213-2600(18)30389-8,https://pubmed.ncbi.nlm.nih.gov/30552067/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,17558408,A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.,2007,10.1038/ng2058,https://pubmed.ncbi.nlm.nih.gov/17558408/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,20184734,The 4q27 locus and prostate cancer risk.,2010,10.1186/1471-2407-10-69,https://pubmed.ncbi.nlm.nih.gov/20184734/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,18840430,Lacritin and other new proteins of the lacrimal functional unit.,2009,10.1016/j.exer.2008.09.002,https://pubmed.ncbi.nlm.nih.gov/18840430/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLTP1,ENSG00000138688,Unsafe,16545529,Molecular cloning of Chinese hamster 1q31 chromosomal fragile site DNA that is important to mdr1 gene amplification reveals a novel gene whose expression is associated with spermatocyte and adipocyte differentiation.,2006,10.1016/j.gene.2005.12.024,https://pubmed.ncbi.nlm.nih.gov/16545529/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,41820452,The role of BLZF1 in lung adenocarcinoma and its value as a diagnostic and prognostic biomarker.,2026,10.1038/s41598-026-40856-1,https://pubmed.ncbi.nlm.nih.gov/41820452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,40651625,Hac1p-based inverse secretory pathway engineering (Hi-SPE) of Pichia pastoris for improved glucose oxidase production.,2025,10.1016/j.nbt.2025.07.002,https://pubmed.ncbi.nlm.nih.gov/40651625/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,37704840,Identification of novel pathogenic roles of BLZF1/ATF6 in tumorigenesis of gastrointestinal stromal tumor showing Golgi-localized mutant KIT.,2023,10.1038/s41418-023-01220-2,https://pubmed.ncbi.nlm.nih.gov/37704840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,41909960,Genetic Parameters and Genome-Wide Association Studies for Fertility and Reproduction Traits in U.S. Katahdin Sheep Based on the Single-Step GBLUP Methodology.,2026,10.1111/jbg.70048,https://pubmed.ncbi.nlm.nih.gov/41909960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,26342799,BLZF1 expression is of prognostic significance in hepatocellular carcinoma.,2015,10.1016/j.bbrc.2015.08.119,https://pubmed.ncbi.nlm.nih.gov/26342799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,32853947,Identification of key genes and pathways in castrate-resistant prostate cancer by integrated bioinformatics analysis.,2020,10.1016/j.prp.2020.153109,https://pubmed.ncbi.nlm.nih.gov/32853947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,27023521,Knock-Down of Endogenous Bornavirus-Like Nucleoprotein 1 Inhibits Cell Growth and Induces Apoptosis in Human Oligodendroglia Cells.,2016,10.3390/ijms17040435,https://pubmed.ncbi.nlm.nih.gov/27023521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,29626196,"Mutation, methylation, and gene expression profiles in dup(1q)-positive pediatric B-cell precursor acute lymphoblastic leukemia.",2018,10.1038/s41375-018-0092-2,https://pubmed.ncbi.nlm.nih.gov/29626196/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,20110346,The endoplasmic reticulum-associated degradation of the epithelial sodium channel requires a unique complement of molecular chaperones.,2010,10.1091/mbc.e09-11-0944,https://pubmed.ncbi.nlm.nih.gov/20110346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,21478859,RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.,2011,10.1038/ncb2222,https://pubmed.ncbi.nlm.nih.gov/21478859/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,18931293,Modulation of chaperone gene expression in mutagenized Saccharomyces cerevisiae strains developed for recombinant human albumin production results in increased production of multiple heterologous proteins.,2008,10.1128/aem.01178-08,https://pubmed.ncbi.nlm.nih.gov/18931293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,22672568,A genome-wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24.2 and 9q.,2012,10.1111/j.1538-7836.2012.04810.x,https://pubmed.ncbi.nlm.nih.gov/22672568/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,18772193,Novel suppressors of alpha-synuclein toxicity identified using yeast.,2008,10.1093/hmg/ddn276,https://pubmed.ncbi.nlm.nih.gov/18772193/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,10069807,"Genetic interactions between KAR7/SEC71, KAR8/JEM1, KAR5, and KAR2 during nuclear fusion in Saccharomyces cerevisiae.",1999,10.1091/mbc.10.3.609,https://pubmed.ncbi.nlm.nih.gov/10069807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,9148890,The yeast JEM1p is a DnaJ-like protein of the endoplasmic reticulum membrane required for nuclear fusion.,1997,10.1074/jbc.272.20.12889,https://pubmed.ncbi.nlm.nih.gov/9148890/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,11056056,Genomic organization of the JEM-1 (BLZF1) gene on human chromosome 1q24: molecular cloning and analysis of its promoter region.,2000,10.1006/geno.2000.6347,https://pubmed.ncbi.nlm.nih.gov/11056056/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,11381090,Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation.,2001,10.1083/jcb.153.5.1061,https://pubmed.ncbi.nlm.nih.gov/11381090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,11739401,A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic.,2001,10.1083/jcb.200108079,https://pubmed.ncbi.nlm.nih.gov/11739401/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BLZF1,ENSG00000117475,Unsafe,9129147,"JEM-1, a novel gene encoding a leucine-zipper nuclear factor upregulated during retinoid-induced maturation of NB4 promyelocytic leukaemia.",1997,10.1038/sj.onc.1200995,https://pubmed.ncbi.nlm.nih.gov/9129147/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,41083582,HSF2BP modulates lung adenocarcinoma proliferation and immune microenvironment via BNC1/TGF-β/SMAD3 signaling pathway.,2025,10.1038/s41598-025-19564-9,https://pubmed.ncbi.nlm.nih.gov/41083582/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,40444282,BNC1 inhibits the development and progression of gastric cancer by regulating the CCL20/JAK-STAT axis.,2025,10.7717/peerj.19477,https://pubmed.ncbi.nlm.nih.gov/40444282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,41833801,Distinct BNC1 variants contribute to premature ovarian insufficiency through different molecular mechanisms.,2026,10.1016/j.gene.2026.150104,https://pubmed.ncbi.nlm.nih.gov/41833801/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,39603023,Down-regulated BNC1 promotes glioma by inhibiting ferroptosis via TCF21/PI3K signaling pathway BNC1TCF21PI3K.,2024,10.1016/j.tice.2024.102633,https://pubmed.ncbi.nlm.nih.gov/39603023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,38079523,BNC1 deficiency induces mitochondrial dysfunction-triggered spermatogonia apoptosis through the CREB/SIRT1/FOXO3 pathway: the therapeutic potential of nicotinamide riboside and metformin†.,2024,10.1093/biolre/ioad168,https://pubmed.ncbi.nlm.nih.gov/38079523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,41393291,Novel variants associated with premature ovarian insufficiency in Russian adolescents.,2025,10.3389/fendo.2025.1687148,https://pubmed.ncbi.nlm.nih.gov/41393291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,39462784,Identification of Two Novel Missense Variants in BNC1 in Han Chinese Patients With Non-syndromic Premature Ovarian Insufficiency.,2025,10.1111/cge.14639,https://pubmed.ncbi.nlm.nih.gov/39462784/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,40762962,Modification of Bacterial Nanocellulose Using Nonthermal Plasma-Assisted Enzymatic Hydrolysis.,2025,10.1021/acs.biomac.5c00397,https://pubmed.ncbi.nlm.nih.gov/40762962/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,37705202,LINC01305 recruits basonuclin 1 to act on G-protein pathway suppressor 1 to promote esophageal squamous cell carcinoma.,2023,10.1111/cas.15963,https://pubmed.ncbi.nlm.nih.gov/37705202/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,39564730,"Blood Plasma Methylated DNA Markers in the Detection of Lymphoma: Discovery, Validation, and Clinical Pilot.",2025,10.1002/ajh.27533,https://pubmed.ncbi.nlm.nih.gov/39564730/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,36198708,BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency.,2022,10.1038/s41467-022-33323-8,https://pubmed.ncbi.nlm.nih.gov/36198708/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,39035743,Novel diagnostic biomarkers for pancreatic cancer: assessing methylation status with epigenetic-specific peptide nucleic acid and KRAS mutation in cell-free DNA.,2024,10.3389/fonc.2024.1395473,https://pubmed.ncbi.nlm.nih.gov/39035743/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,38614076,Toward clinical exomes in diagnostics and management of male infertility.,2024,10.1016/j.ajhg.2024.03.013,https://pubmed.ncbi.nlm.nih.gov/38614076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,40962202,PRMT1 Inhibition Targets BNC1-Dependent Proliferation in Squamous Cell Carcinoma.,2026,10.1016/j.jid.2025.08.043,https://pubmed.ncbi.nlm.nih.gov/40962202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,34644201,Clinicopathological significance and underlying molecular mechanism of downregulation of basonuclin 1 expression in ovarian carcinoma.,2022,10.1177/15353702211052036,https://pubmed.ncbi.nlm.nih.gov/34644201/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,33211273,BNC1 Promotes Spermatogenesis by Regulating Transcription of Ybx2 and Papolb via Direct Binding to Their Promotor Elements.,2021,10.1007/s43032-020-00342-z,https://pubmed.ncbi.nlm.nih.gov/33211273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,36803844,Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms.,2023,10.1186/s13148-023-01429-5,https://pubmed.ncbi.nlm.nih.gov/36803844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,39548146,"Population structure and selective signature analysis of local sheep breeds in Xinjiang, China based on high-density SNP chip.",2024,10.1038/s41598-024-76573-w,https://pubmed.ncbi.nlm.nih.gov/39548146/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,31065688,Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis.,2020,10.1093/jmcb/mjz035,https://pubmed.ncbi.nlm.nih.gov/31065688/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,38672141,Exome Sequencing to Identify Novel Variants Associated with Secondary Amenorrhea and Premature Ovarian Insufficiency (POI) in Saudi Women.,2024,10.3390/biomedicines12040785,https://pubmed.ncbi.nlm.nih.gov/38672141/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,40868708,Designing Gel-Inspired Food-Grade O/W Pickering Emulsions with Bacterial Nanocellulose-Chitosan Complexes.,2025,10.3390/gels11080577,https://pubmed.ncbi.nlm.nih.gov/40868708/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,34148047,Upregulation of Basonuclin1 Is Associated with p63-Involved Epithelial Barrier Impairment and Type-2 Helper T-cell Inflammation in Chronic Rhinosinusitis with Nasal Polyps.,2021,10.1159/000516810,https://pubmed.ncbi.nlm.nih.gov/34148047/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,36010535,Establishment and Validation of Reference Genes of Brassica napus L. for Digital PCR Detection of Genetically Modified Canola.,2022,10.3390/foods11162535,https://pubmed.ncbi.nlm.nih.gov/36010535/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,42465592,&lt;i&gt;All-in-one&lt;/i&gt; exome sequencing approach for genetic testing of unexplained premature ovarian insufficiency.,2026,10.1093/hropen/hoag058,https://pubmed.ncbi.nlm.nih.gov/42465592/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,35987357,Cellulosic fabrics modified with polyphosphonium chitosan hydrazone-TiO2-Ag nanobiocomposites for multifunctional applications.,2022,10.1016/j.ijbiomac.2022.08.104,https://pubmed.ncbi.nlm.nih.gov/35987357/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,30953539,Promoter methylation of ADAMTS1 and BNC1 as potential biomarkers for early detection of pancreatic cancer in blood.,2019,10.1186/s13148-019-0650-0,https://pubmed.ncbi.nlm.nih.gov/30953539/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,34193030,Integration of a single-step genome-wide association study with a multi-tissue transcriptome analysis provides novel insights into the genetic basis of wool and weight traits in sheep.,2021,10.1186/s12711-021-00649-8,https://pubmed.ncbi.nlm.nih.gov/34193030/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,35289095,Molecular profile of pure squamous cell carcinoma of the bladder identifies major roles for OSMR and YAP signalling.,2022,10.1002/cjp2.261,https://pubmed.ncbi.nlm.nih.gov/35289095/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,34526665,Multi-omics mapping of human papillomavirus integration sites illuminates novel cervical cancer target genes.,2021,10.1038/s41416-021-01545-0,https://pubmed.ncbi.nlm.nih.gov/34526665/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,31313401,Targeting cholecystokinin-2 receptor for pancreatic cancer chemoprevention.,2019,10.1002/mc.23084,https://pubmed.ncbi.nlm.nih.gov/31313401/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,20484983,Genome-wide DNA methylation profiling of chronic lymphocytic leukemia allows identification of epigenetically repressed molecular pathways with clinical impact.,2010,10.4161/epi.5.6.12179,https://pubmed.ncbi.nlm.nih.gov/20484983/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,17873047,Evidence that bacterial ABC-type transporter imports free EDTA for metabolism.,2007,10.1128/jb.01164-07,https://pubmed.ncbi.nlm.nih.gov/17873047/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,27891190,Cell-free DNA promoter hypermethylation in plasma as a diagnostic marker for pancreatic adenocarcinoma.,2016,10.1186/s13148-016-0286-2,https://pubmed.ncbi.nlm.nih.gov/27891190/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,18164625,Expression and purification of BmrI restriction endonuclease and its N-terminal cleavage domain variants.,2008,10.1016/j.pep.2007.11.002,https://pubmed.ncbi.nlm.nih.gov/18164625/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,30010909,Basonuclin 1 deficiency is a cause of primary ovarian insufficiency.,2018,10.1093/hmg/ddy261,https://pubmed.ncbi.nlm.nih.gov/30010909/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,16891417,"Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions.",2006,10.1073/pnas.0605086103,https://pubmed.ncbi.nlm.nih.gov/16891417/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,9687312,Translocation of the zinc finger protein basonuclin from the mouse germ cell nucleus to the midpiece of the spermatozoon during spermiogenesis.,1998,10.1095/biolreprod59.2.388,https://pubmed.ncbi.nlm.nih.gov/9687312/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BNC1,ENSG00000169594,Unsafe,8034748,Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation.,1994,10.1083/jcb.126.2.495,https://pubmed.ncbi.nlm.nih.gov/8034748/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOD1L2,ENSG00000228075,Unsafe,41417274,A busy BOD1-y: the diverse functions of an intracellular signaling regulatory protein family.,2025,10.1042/bst20253107,https://pubmed.ncbi.nlm.nih.gov/41417274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOD1L2,ENSG00000228075,Unsafe,37083227,Deciphering the Molecular Characteristics of Human Idiopathic Nonobstructive Azoospermia from the Perspective of Germ Cells.,2023,10.1002/advs.202206852,https://pubmed.ncbi.nlm.nih.gov/37083227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BOD1L2,ENSG00000228075,Unsafe,37345113,Genome-Wide Association Study of Breast Density among Women of African Ancestry.,2023,10.3390/cancers15102776,https://pubmed.ncbi.nlm.nih.gov/37345113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,42793181,SPLUNC1/BPIFA1 Restrains Neutrophil-Dominant Inflammation and Coordinated Inflammatory Gene Programs During LPS-Induced Lung Injury.,2026,10.3390/biom16091349,https://pubmed.ncbi.nlm.nih.gov/42793181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,42650786,SMAD4-BPIFA1 Axis Governs Airway Antiviral Defense in Myhre Syndrome.,2026,10.3390/biom16081118,https://pubmed.ncbi.nlm.nih.gov/42650786/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,40589325,Is the SPLUNC1-Orai1 axis a critical determinant of lung health?,2025,10.1042/bst20241029,https://pubmed.ncbi.nlm.nih.gov/40589325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,42769069,Identification of key genes and metabolites in thyroid eye disease through integrated transcriptomic and metabolomic analysis.,2026,10.3389/fendo.2026.1844082,https://pubmed.ncbi.nlm.nih.gov/42769069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,42198612,Differential Interactions of Tissue-Restricted Host Proteins SPLUNC1 and VAMP8 with VP3 of Human Bocaviruses 1 and 2.,2026,10.3390/pathogens15050486,https://pubmed.ncbi.nlm.nih.gov/42198612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,40427066,The Potential Role of SP-G and PLUNC in Tumor Pathogenesis and Wound Healing in the Human Larynx.,2025,10.3390/biomedicines13051240,https://pubmed.ncbi.nlm.nih.gov/40427066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,39970751,BPIFA1 inhibits periodontitis by regulating the NF-κB/IκB signaling pathway and macrophage M1/M2 polarization.,2025,10.1016/j.archoralbio.2025.106190,https://pubmed.ncbi.nlm.nih.gov/39970751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,42139518,Characterization of Mucosal BPI fold-containing family A member 1-High-Expressing Neutrophils and their Immune Defense roles in Severe Acute Respiratory Syndrome Coronavirus 2 Breakthrough Infection via single-cell RNA sequencing.,2026,10.1093/infdis/jiag267,https://pubmed.ncbi.nlm.nih.gov/42139518/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,41630257,Evaluating the diagnostic and prognostic role of bronchoscopy combined with brush cytology in peripheral lung cancer.,2026,10.1097/md.0000000000047118,https://pubmed.ncbi.nlm.nih.gov/41630257/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,39815745,PLUNC downregulates the expression of PD-L1 by inhibiting the interaction of DDX17/β-catenin in nasopharyngeal carcinoma.,2025,10.4132/jptm.2024.11.27,https://pubmed.ncbi.nlm.nih.gov/39815745/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,42476371,Impaired CC16-mediated host responses to rhinovirus in nasal epithelial cells from patients with asthma.,2026,10.1016/j.jaci.2026.06.021,https://pubmed.ncbi.nlm.nih.gov/42476371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,42126092,Longitudinal circulating procollagen-markers PRO-C1 and PRO-C2 reflect pubertal growth spurt in healthy adolescents.,2026,10.1210/clinem/dgag203,https://pubmed.ncbi.nlm.nih.gov/42126092/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,41974709,Transient remodeling of gut metabolism supports juvenile growth and adult fitness in Drosophila.,2026,10.1038/s41467-026-71776-3,https://pubmed.ncbi.nlm.nih.gov/41974709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,39735594,A Preliminary Study on Transcriptional Regulation of SNP Site C-1888T in the Promoter Region of Human PLUNC Gene and Nasopharyngeal Carcinoma Susceptibility.,2024,10.1155/genr/5148918,https://pubmed.ncbi.nlm.nih.gov/39735594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,41972129,Case Report: &lt;i&gt;Pseudomonas&lt;/i&gt; liver abscess in a previously healthy child with homozygous pathogenic S allele variant of the &lt;i&gt;SERPINA1&lt;/i&gt; gene.,2026,10.3389/fimmu.2026.1755963,https://pubmed.ncbi.nlm.nih.gov/41972129/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,32405534,LunX-CAR T Cells as a Targeted Therapy for Non-Small Cell Lung Cancer.,2020,10.1016/j.omto.2020.04.008,https://pubmed.ncbi.nlm.nih.gov/32405534/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,39501021,UBR5 metabolically reprograms nasopharyngeal carcinoma cells to promote glycolysis and M2 polarization via SPLUNC1 signaling.,2024,10.1038/s41698-024-00747-y,https://pubmed.ncbi.nlm.nih.gov/39501021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,41749598,Morphometric Findings in Adolescents with Robin Sequence: A Photographic and Cephalometric Study of the Face and Mandible.,2026,10.3390/children13020242,https://pubmed.ncbi.nlm.nih.gov/41749598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,38660271,Integrated bioinformatics analysis and experimental animal models identify a robust biomarker and its correlation with the immune microenvironment in pulmonary arterial hypertension.,2024,10.1016/j.heliyon.2024.e29587,https://pubmed.ncbi.nlm.nih.gov/38660271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,42281158,Craniofacial Growth in Patients With Cleft Before and After Puberty: A Longitudinal Case-Control Study.,2026,10.1111/ocr.70156,https://pubmed.ncbi.nlm.nih.gov/42281158/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,41481339,Considerations for Clinical Trial Design in Relapsed and Refractory Osteosarcoma: An FDA Symposium.,2026,10.1158/1078-0432.ccr-25-3282,https://pubmed.ncbi.nlm.nih.gov/41481339/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,40010780,Systematic review of the barriers and facilitators to the implementation of non-pneumatic antishock garments in low- and middle-income countries: lessons for global health.,2025,10.1136/bmjgh-2024-017681,https://pubmed.ncbi.nlm.nih.gov/40010780/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,38031166,"Operational demonstration and process evaluation of non-pneumatic anti-shock garment (NASG) introduction to the public health system of Northern Province, Zambia.",2023,10.1186/s12913-023-10294-0,https://pubmed.ncbi.nlm.nih.gov/38031166/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,39090626,Nonpneumatic anti-shock garment utilization for obstetric hemorrhage management and its predictors among obstetric care providers in Ethiopia: a systematic review and meta-analysis.,2024,10.1186/s12913-024-11333-0,https://pubmed.ncbi.nlm.nih.gov/39090626/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,41895698,The impact of a continuum of care intervention from prevention to treatment on child wasting compared with usual community group activities: a cluster-randomized controlled trial in Mali.,2026,10.1016/j.ajcnut.2026.101294,https://pubmed.ncbi.nlm.nih.gov/41895698/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,41715094,Quercetin-loaded silicon dioxide-graphene nanoparticles promotes M2 macrophage reprogramming in mycoplasma-induced pneumonia.,2026,10.1186/s12950-026-00484-y,https://pubmed.ncbi.nlm.nih.gov/41715094/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,38129408,USP7 inhibits the progression of nasopharyngeal carcinoma via promoting SPLUNC1-mediated M1 macrophage polarization through TRIM24.,2023,10.1038/s41419-023-06368-w,https://pubmed.ncbi.nlm.nih.gov/38129408/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,42099224,Effects of maturational status on physical performance of elite youth football players.,2026,10.23736/s0022-4707.26.17661-0,https://pubmed.ncbi.nlm.nih.gov/42099224/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,38874951,The effect of forced even pacing and an opponent on end-spurt behaviour in freestyle pool swimming.,2024,10.1002/ejsc.12102,https://pubmed.ncbi.nlm.nih.gov/38874951/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,37223955,Lung SPLUNC1 Peptide Derivatives in the Lipid Membrane Headgroup Kill Gram-Negative Planktonic and Biofilm Bacteria.,2023,10.1021/acs.biomac.3c00218,https://pubmed.ncbi.nlm.nih.gov/37223955/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,41921012,Induction of puberty in hypogonadal forms of primary amenorrhoea: current evidence and future perspectives.,2026,10.1530/ec-25-0811,https://pubmed.ncbi.nlm.nih.gov/41921012/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,39376676,The estimation of pubertal growth spurt parameters using the superimposition by translation and rotation model in Korean children and adolescents: a longitudinal cohort study.,2024,10.3389/fped.2024.1372013,https://pubmed.ncbi.nlm.nih.gov/39376676/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,39963614,Role of Adjuvant Radiotherapy in Sweat Gland Carcinoma: A Case Report and Literature Review.,2025,10.7759/cureus.77628,https://pubmed.ncbi.nlm.nih.gov/39963614/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,39982813,Culture conditions differentially regulate the inflammatory niche and cellular phenotype of tracheobronchial basal stem cells.,2025,10.1152/ajplung.00293.2024,https://pubmed.ncbi.nlm.nih.gov/39982813/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,26559477,"Palate Lung Nasal Clone (PLUNC), a Novel Protein of the Tear Film: Three-Dimensional Structure, Immune Activation, and Involvement in Dry Eye Disease (DED).",2015,10.1167/iovs.15-17560,https://pubmed.ncbi.nlm.nih.gov/26559477/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,12409287,"Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts.",2003,10.1074/jbc.m210523200,https://pubmed.ncbi.nlm.nih.gov/12409287/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,11425234,"Identification of a new potential airway irritation marker, palate lung nasal epithelial clone protein, in human nasal lavage fluid with two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight.",2001,10.1002/1522-2683(200105)22:9<1795::aid-elps1795>3.0.co;2-j,https://pubmed.ncbi.nlm.nih.gov/11425234/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,11251963,"Isolation of a novel human lung-specific gene, LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer.",2001,10.1002/1097-0215(200002)9999:9999<::aid-ijc1059>3.0.co;2-b,https://pubmed.ncbi.nlm.nih.gov/11251963/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA1,ENSG00000198183,Unsafe,11018263,"Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern.",2000,10.1016/s0167-4781(00)00196-2,https://pubmed.ncbi.nlm.nih.gov/11018263/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,42346120,BPIFA2 Promotes Renal Fibrosis by Regulating Tubular Epithelial-to-Mesenchymal Transition and Macrophage Activation in Chronic Kidney Disease.,2026,10.3390/cells15121093,https://pubmed.ncbi.nlm.nih.gov/42346120/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,42698073,Current smoking and COPD are associated with differentiation-dependent secretory and inflammatory programs in airway basal cells.,2026,10.1186/s12931-026-03847-4,https://pubmed.ncbi.nlm.nih.gov/42698073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,40543103,The BPIFA2 - LRP5 axis orchestrates mitochondrial dysfunction to mediate kidney injury in lupus nephritis.,2025,10.1016/j.intimp.2025.115114,https://pubmed.ncbi.nlm.nih.gov/40543103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,40565086,Changes in the Protein Profile of Saliva from People with Obesity Treated with Bariatric Surgery and Physical Exercise.,2025,10.3390/ijms26125622,https://pubmed.ncbi.nlm.nih.gov/40565086/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,39201484,Comparison of Peptidomes Extracted from Healthy Tissue and Tumor Tissue of the Parotid Glands and Saliva Samples.,2024,10.3390/ijms25168799,https://pubmed.ncbi.nlm.nih.gov/39201484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,42320172,"Lack of alpha1,2-fucosylation protects mice from bleomycin-induced lung fibrosis: A quantitative proteomic analysis of bronchoalveolar lavage fluid.",2026,10.1016/j.carres.2026.110010,https://pubmed.ncbi.nlm.nih.gov/42320172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,32390232,The parotid secretory protein BPIFA2 is a salivary surfactant that affects lipopolysaccharide action.,2020,10.1113/ep088567,https://pubmed.ncbi.nlm.nih.gov/32390232/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,36012391,RNA-Seq Analysis of UPM-Exposed Epithelium Co-Cultivated with Macrophages and Dendritic Cells in Obstructive Lung Diseases.,2022,10.3390/ijms23169125,https://pubmed.ncbi.nlm.nih.gov/36012391/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,35431693,BPIFA2 as a Novel Early Biomarker to Identify Fatal Radiation Injury After Radiation Exposure.,2022,10.1177/15593258221086478,https://pubmed.ncbi.nlm.nih.gov/35431693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,39040362,TGF-β1 maintains the developmental potential of embryonic submandibular gland epithelia separated with mesenchyme.,2024,10.1016/j.heliyon.2024.e33506,https://pubmed.ncbi.nlm.nih.gov/39040362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,33682222,Salivary BPIFA proteins are altered in patients undergoing hematopoietic cell transplantation.,2022,10.1111/odi.13832,https://pubmed.ncbi.nlm.nih.gov/33682222/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,28775000,BPI Fold-Containing Family A Member 2/Parotid Secretory Protein Is an Early Biomarker of AKI.,2017,10.1681/asn.2016121265,https://pubmed.ncbi.nlm.nih.gov/28775000/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,25482547,Salivary BPIFA1 (SPLUNC1) and BPIFA2 (SPLUNC2 A) are modified by head and neck cancer radiotherapy.,2015,10.1016/j.oooo.2014.09.026,https://pubmed.ncbi.nlm.nih.gov/25482547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,31095438,Profiling Autoantibodies against Salivary Proteins in Sicca Conditions.,2019,10.1177/0022034519850564,https://pubmed.ncbi.nlm.nih.gov/31095438/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,31268775,"Renal progenitor cells revert LPS-induced endothelial-to-mesenchymal transition by secreting CXCL6, SAA4, and BPIFA2 antiseptic peptides.",2019,10.1096/fj.201900351r,https://pubmed.ncbi.nlm.nih.gov/31268775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,22484285,Lysine substitutions convert a bacterial-agglutinating peptide into a bactericidal peptide that retains anti-lipopolysaccharide activity and low hemolytic activity.,2012,10.1016/j.peptides.2012.03.017,https://pubmed.ncbi.nlm.nih.gov/22484285/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,36670100,Longitudinal efficacy and toxicity of SARS-CoV-2 vaccination in cancer patients treated with immunotherapy.,2023,10.1038/s41419-022-05548-4,https://pubmed.ncbi.nlm.nih.gov/36670100/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,33283556,Particulate matter less than 10 μm (PM10) activates cancer related genes in lung epithelial cells.,2020,10.1080/08958378.2020.1850936,https://pubmed.ncbi.nlm.nih.gov/33283556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,28099576,BPI-fold (BPIF) containing/plunc protein expression in human fetal major and minor salivary glands.,2017,10.1590/1807-3107bor-2017.vol31.0006,https://pubmed.ncbi.nlm.nih.gov/28099576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,33933610,Effect of Myd88 deficiency on gene expression profiling in salivary glands of female non-obese diabetic (NOD) mice.,2021,10.1016/j.job.2021.04.003,https://pubmed.ncbi.nlm.nih.gov/33933610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,21787342,Dual host-defence functions of SPLUNC2/PSP and synthetic peptides derived from the protein.,2011,10.1042/bst0391028,https://pubmed.ncbi.nlm.nih.gov/21787342/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,30182113,Effect of lactoferrin on taste and smell abnormalities induced by chemotherapy: a proteome analysis.,2018,10.1039/c8fo00813b,https://pubmed.ncbi.nlm.nih.gov/30182113/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,25372402,Antimicrobial GL13K peptide coatings killed and ruptured the wall of Streptococcus gordonii and prevented formation and growth of biofilms.,2014,10.1371/journal.pone.0111579,https://pubmed.ncbi.nlm.nih.gov/25372402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,21833535,Human parotid secretory protein is a lipopolysaccharide-binding protein: identification of an anti-inflammatory peptide domain.,2012,10.1007/s11010-011-0991-2,https://pubmed.ncbi.nlm.nih.gov/21833535/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,24581853,"Isolation, biochemical characterization and anti-bacterial activity of BPIFA2 protein.",2014,10.1016/j.archoralbio.2013.12.005,https://pubmed.ncbi.nlm.nih.gov/24581853/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFA2,ENSG00000131050,Unsafe,11971875,PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx.,2002,10.1093/hmg/11.8.937,https://pubmed.ncbi.nlm.nih.gov/11971875/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFC,ENSG00000184459,Unsafe,41511345,T-Cell-Driven Immunopathology and Fibrotic Remodeling in Hypertrophic Cardiomyopathy: A Translational Scoping Review.,2025,10.3390/cells15010061,https://pubmed.ncbi.nlm.nih.gov/41511345/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFC,ENSG00000184459,Unsafe,38474063,Transcriptomic Analyses and Experimental Validation Identified Immune-Related lncRNA-mRNA Pair MIR210HG-BPIFC Regulating the Progression of Hypertrophic Cardiomyopathy.,2024,10.3390/ijms25052816,https://pubmed.ncbi.nlm.nih.gov/38474063/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFC,ENSG00000184459,Unsafe,41153404,A Genome-Wide Association Study in Psoriasis Patients Reveals Variants Associated with Response to Treatment with Interleukin-17A Pathway Inhibitors.,2025,10.3390/genes16101187,https://pubmed.ncbi.nlm.nih.gov/41153404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFC,ENSG00000184459,Unsafe,39164087,Comprehensive genome-wide analysis of genetic loci and candidate genes associated with litter traits in purebred Berkshire pigs of Korea.,2024,10.5713/ab.24.0046,https://pubmed.ncbi.nlm.nih.gov/39164087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFC,ENSG00000184459,Unsafe,31033252,Novel heterozygous BPIFC variant in a Chinese pedigree with hereditary trichilemmal cysts.,2019,10.1002/mgg3.697,https://pubmed.ncbi.nlm.nih.gov/31033252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFC,ENSG00000184459,Unsafe,19303879,New hypotheses on the function of the avian shell gland derived from microarray analysis comparing tissue from juvenile and sexually mature hens.,2009,10.1016/j.ygcen.2009.03.006,https://pubmed.ncbi.nlm.nih.gov/19303879/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFC,ENSG00000184459,Unsafe,24190013,Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA.,2014,10.1007/s00439-013-1383-3,https://pubmed.ncbi.nlm.nih.gov/24190013/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BPIFC,ENSG00000184459,Unsafe,12185532,Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP).,2002,10.1007/s00251-002-0467-3,https://pubmed.ncbi.nlm.nih.gov/12185532/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,42919397,BRAP maintains SEC24D stability to regulate ER stress and promote cervical adenocarcinoma progression.,2026,10.1186/s12967-026-08780-0,https://pubmed.ncbi.nlm.nih.gov/42919397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,41427116,BRAP Promotes the Tumorigenesis of Hepatocellular Carcinoma by Corrupting Cancer Cell Cycle Regulation and Enhancing Immune Evasion.,2025,10.2147/jhc.s547105,https://pubmed.ncbi.nlm.nih.gov/41427116/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,42277437,Optimized post-GWAS analysis identifies therapeutic targets for essential thrombocythemia and polycythemia vera.,2026,10.1038/s43856-026-01599-2,https://pubmed.ncbi.nlm.nih.gov/42277437/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,41920083,BRAP Homologue Deficiency Exacerbates Airway Inflammation in Mouse Models of Experimental Asthma-Like Disease.,2026,10.1111/1440-1681.70119,https://pubmed.ncbi.nlm.nih.gov/41920083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,41932562,Bombesin receptor-activated protein homolog deficiency reduces food intake and alleviates metabolic dysfunction in high-fat diet treated mice.,2026,10.1016/j.physbeh.2026.115330,https://pubmed.ncbi.nlm.nih.gov/41932562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,38169666,Bombesin receptor-activated protein homolog deficiency altered the pattern of pathological changes of psoriasis - like skin lesion in mice.,2024,10.7150/ijms.89492,https://pubmed.ncbi.nlm.nih.gov/38169666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,37647369,"BRAP silencing protects against neuronal inflammation, oxidative stress and apoptosis in cerebral ischemia-reperfusion injury by promoting PON1 expression.",2023,10.1002/tox.23899,https://pubmed.ncbi.nlm.nih.gov/37647369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,39155151,Attenuation of renal fibrosis in mice due to lack of bombesin receptor-activated protein homologue.,2024,10.1111/1440-1681.13916,https://pubmed.ncbi.nlm.nih.gov/39155151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,37715941,Knockout of the BRAP homolog in mice leads to abnormal tracheal cilia.,2023,10.1002/1873-3468.14734,https://pubmed.ncbi.nlm.nih.gov/37715941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,35754718,Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration.,2022,10.1016/j.isci.2022.104519,https://pubmed.ncbi.nlm.nih.gov/35754718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,42133815,Shared proteomic landscape between arteriosclerosis and cardiovascular endpoints: a Mendelian randomization and observational study integrating AlphaFold3 for structural prediction.,2026,10.1093/cvr/cvag095,https://pubmed.ncbi.nlm.nih.gov/42133815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,33240929,BRCA1-Associated Protein Is a Potential Prognostic Biomarker and Is Correlated With Immune Infiltration in Liver Hepatocellular Carcinoma: A Pan-Cancer Analysis.,2020,10.3389/fmolb.2020.573619,https://pubmed.ncbi.nlm.nih.gov/33240929/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,35476518,Brap regulates liver morphology and hepatocyte turnover via modulation of the Hippo pathway.,2022,10.1073/pnas.2201859119,https://pubmed.ncbi.nlm.nih.gov/35476518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,35820707,Lack of bombesin receptor-activated protein attenuates bleomycin-induced pulmonary fibrosis in mice.,2022,10.26508/lsa.202201368,https://pubmed.ncbi.nlm.nih.gov/35820707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,35488871,Bombesin receptor-activated protein exacerbates cisplatin-induced AKI by regulating the degradation of SIRT2.,2022,10.1093/ndt/gfac164,https://pubmed.ncbi.nlm.nih.gov/35488871/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,38448893,SNP-based and haplotype-based genome-wide association on drug dependence in Han Chinese.,2024,10.1186/s12864-024-10117-4,https://pubmed.ncbi.nlm.nih.gov/38448893/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,41175382,Protein and gene levels of DNAJC21 and RNF5 as drug targets for immune thrombocytopenia: optimized post-GWAS insights.,2025,10.1080/16078454.2025.2580060,https://pubmed.ncbi.nlm.nih.gov/41175382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,35625983,Mutation of PTPN11 (Encoding SHP-2) Promotes MEK Activation and Malignant Progression in Neurofibromin-Deficient Cells in a Manner Sensitive to BRAP Mutation.,2022,10.3390/cancers14102377,https://pubmed.ncbi.nlm.nih.gov/35625983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,28768733,Central catalytic domain of BRAP (RNF52) recognizes the types of ubiquitin chains and utilizes oligo-ubiquitin for ubiquitylation.,2017,10.1042/bcj20161104,https://pubmed.ncbi.nlm.nih.gov/28768733/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,36520154,Lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice.,2023,10.1080/10253890.2022.2155513,https://pubmed.ncbi.nlm.nih.gov/36520154/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,38824267,Key Opinion Leaders' Interviews to Inform the Future of Benefit-Risk Planning in the Medical Total Product Life Cycle of Global Pharmaceutical and Medical Device Organizations.,2024,10.1007/s40264-024-01442-4,https://pubmed.ncbi.nlm.nih.gov/38824267/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,33093602,"CUX2, BRAP and ALDH2 are associated with metabolic traits in people with excessive alcohol consumption.",2020,10.1038/s41598-020-75199-y,https://pubmed.ncbi.nlm.nih.gov/33093602/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,37511963,Progression of Carotid Intima-Media Thickness Partly Indicates the Prevention of Hypertension among Older Individuals in the General Population.,2023,10.3390/life13071588,https://pubmed.ncbi.nlm.nih.gov/37511963/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,30703135,Role of BRCA1-associated protein (BRAP) variant in childhood pulmonary arterial hypertension.,2019,10.1371/journal.pone.0211450,https://pubmed.ncbi.nlm.nih.gov/30703135/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,35088020,"Putative regulatory functions of SNPs associated with bronchial asthma, arterial hypertension and their comorbid phenotype.",2021,10.18699/vj21.099,https://pubmed.ncbi.nlm.nih.gov/35088020/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,26563741,Hydrogen peroxide-activatable antioxidant prodrug as a targeted therapeutic agent for ischemia-reperfusion injury.,2015,10.1038/srep16592,https://pubmed.ncbi.nlm.nih.gov/26563741/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,28600327,The Oxidative Stress Response in Caenorhabditis elegans Requires the GATA Transcription Factor ELT-3 and SKN-1/Nrf2.,2017,10.1534/genetics.116.198788,https://pubmed.ncbi.nlm.nih.gov/28600327/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,33514303,Possible mechanisms underlying the association between human T-cell leukemia virus type 1 (HTLV-1) and hypertension in elderly Japanese population.,2021,10.1186/s12199-021-00938-0,https://pubmed.ncbi.nlm.nih.gov/33514303/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,29016630,Association between kidney function and genetic polymorphisms in atherosclerotic and chronic kidney diseases: A cross-sectional study in Japanese male workers.,2017,10.1371/journal.pone.0185476,https://pubmed.ncbi.nlm.nih.gov/29016630/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,33079445,Platelet Glycoprotein Ib α-Chain as a Putative Therapeutic Target for Juvenile Idiopathic Arthritis: A Mendelian Randomization Study.,2021,10.1002/art.41561,https://pubmed.ncbi.nlm.nih.gov/33079445/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,27245511,Effect of dietary energy and polymorphisms in BRAP and GHRL on obesity and metabolic traits.,2018,10.1016/j.orcp.2016.05.004,https://pubmed.ncbi.nlm.nih.gov/27245511/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,29691385,Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese.,2018,10.1038/s41467-018-03274-0,https://pubmed.ncbi.nlm.nih.gov/29691385/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,23356535,Lack of association between a functional variant of the BRCA-1 related associated protein (BRAP) gene and ischemic stroke.,2013,10.1186/1471-2350-14-17,https://pubmed.ncbi.nlm.nih.gov/23356535/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,12800198,Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia.,2003,10.1002/ijc.11200,https://pubmed.ncbi.nlm.nih.gov/12800198/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,6973453,Localized chemotherapy of Gardner's lymphosarcoma of C3H mice using combinations of carrier-sorbed antifolics and detoxicating tetrahydrofolates.,1981,,https://pubmed.ncbi.nlm.nih.gov/6973453/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRAP,ENSG00000089234,Unsafe,9497340,Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs.,1998,10.1074/jbc.273.11.6183,https://pubmed.ncbi.nlm.nih.gov/9497340/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,41170905,Unique hematological presentation of patients with biallelic inactivation of FANCD1/BRCA2.,2026,10.1182/bloodadvances.2025017541,https://pubmed.ncbi.nlm.nih.gov/41170905/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42311506,"Double jeopardy: how &lt;i&gt;BRCA2&lt;/i&gt;, &lt;i&gt;TP53&lt;/i&gt;, and &lt;i&gt;DNMT3A&lt;/i&gt; redefine the link between infertility and cancer risk.",2026,10.3389/fcell.2026.1803566,https://pubmed.ncbi.nlm.nih.gov/42311506/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42791527,Pathogenic germline variants in BRCA1/2 are associated with a decreased number of hypomethylated rDNA copies.,2026,10.1186/s13058-026-02387-5,https://pubmed.ncbi.nlm.nih.gov/42791527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42883702,The Enemy of My Enemy: Two Cases of De Novo Metastatic Small-Cell Neuroendocrine Prostate Cancer with BRCA2 Alterations and Brain Metastases.,2026,10.3390/ijms27198453,https://pubmed.ncbi.nlm.nih.gov/42883702/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,40724944,&lt;i&gt;BRCA2&lt;/i&gt; Pre-mRNA Differential 5' Splicing: A Rescue of Functional Protein Properties from Pathogenic Gene Variants and a Lifeline for Fanconi Anemia D1 Patients.,2025,10.3390/ijms26146694,https://pubmed.ncbi.nlm.nih.gov/40724944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,41870214,Gastric Epithelium from BRCA1 and BRCA2 Carriers Harbors Increased Double-Stranded DNA Damage and Enhanced Growth Potential.,2026,10.1158/1541-7786.mcr-25-0970,https://pubmed.ncbi.nlm.nih.gov/41870214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,41596585,Whole-Genome Resequencing Analysis Reveals Insights into Sex Determination and Gene Loci Associated with Sex Differences in &lt;i&gt;Procambarus clarkii&lt;/i&gt;.,2026,10.3390/ijms27020938,https://pubmed.ncbi.nlm.nih.gov/41596585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,41950573,BRCA1 and BRCA2 pathogenic variants increase the risk of four less common cancer types.,2026,10.1016/j.esmoop.2026.106900,https://pubmed.ncbi.nlm.nih.gov/41950573/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42794930,"A Multiplex RT-QPCR Assay of ONECUT2, EZH2, and BRCA2 for the Detection of Clinically Significant Prostate Cancer in Needle Biopsies.",2026,10.3390/cancers18182962,https://pubmed.ncbi.nlm.nih.gov/42794930/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42894850,Polymerase iota coordinates adaptation to replication stress in BRCA2-deficient mammary epithelial cells.,2026,10.1016/j.isci.2026.117830,https://pubmed.ncbi.nlm.nih.gov/42894850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,41848520,"Reclassification of a BRCA2 variant, c.8487G &gt; A (p.Gln2829Gln) located at 3' end of exon 19, from uncertain significance to likely pathogenic based on splicing alteration: a case report.",2026,10.1093/jjco/hyag047,https://pubmed.ncbi.nlm.nih.gov/41848520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42435432,Beyond cancer: breast cancer gene 2 emerges as a new player in atherosclerosis.,2026,10.1152/ajpheart.00790.2025,https://pubmed.ncbi.nlm.nih.gov/42435432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42795000,Somatic Mutation Profile in Normal Tissue Adjacent to Tumor in Colorectal Carcinoma Patients: Functional Effect on Gene Expression and Potential Implications for Precision Medicine.,2026,10.3390/cancers18183034,https://pubmed.ncbi.nlm.nih.gov/42795000/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42714266,Preimplantation genetic testing for concurrent Meckel Syndrome and hereditary breast cancer in a Chinese family harboring a novel NPHP3 pathogenic variant and a canonical BRCA2 frameshift variant.,2026,10.1590/1678-4685-gmb-2025-0063,https://pubmed.ncbi.nlm.nih.gov/42714266/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42238311,CXorf67 in malignancies: Deciphering epigenetic landscapes and clinical implications for precision oncology.,2026,10.1016/j.gendis.2025.101933,https://pubmed.ncbi.nlm.nih.gov/42238311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42274517,BRCA1/2 Reversion Mutations and Cancer Therapy Resistance.,2026,10.3390/biology15110866,https://pubmed.ncbi.nlm.nih.gov/42274517/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,41172994,"BRCA1-, BRCA2-, and PALB2-related Fanconi anemia: Scope to expand disease phenotypic features and predict breast cancer risk in heterozygotes.",2025,10.1016/j.ajhg.2025.10.007,https://pubmed.ncbi.nlm.nih.gov/41172994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42774753,Prognostic and therapeutic implications of BRCA1 and BRCA2 mutations in ovarian cancer.,2026,10.3389/fonc.2026.1899836,https://pubmed.ncbi.nlm.nih.gov/42774753/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,41960042,"Presence and prevalence of single nucleotide sequence polymorphisms in &lt;i&gt;TP53&lt;/i&gt; and &lt;i&gt;BRCA2&lt;/i&gt; genes as of cervical and ovarian cancers in women using hormonal contraceptives in Abuja, Nigeria.",2026,10.4102/jphia.v17i1.1453,https://pubmed.ncbi.nlm.nih.gov/41960042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42073491,Dynamics of Postmortem Gene Expression in Normal and Neoplastic Murine Liver.,2026,10.3390/life16040683,https://pubmed.ncbi.nlm.nih.gov/42073491/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42491848,Reversal of T cell exhaustion enables cancer vaccine efficacy in &lt;i&gt;BRCA1&lt;/i&gt;-deficient ovarian cancer.,2026,10.1016/j.isci.2026.116587,https://pubmed.ncbi.nlm.nih.gov/42491848/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42645357,Targeted Therapy in Pancreatic Ductal Adenocarcinoma: Current Advances and Challenges.,2026,10.3390/curroncol33080452,https://pubmed.ncbi.nlm.nih.gov/42645357/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42489677,A Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02.,2026,10.1158/1078-0432.ccr-25-1114,https://pubmed.ncbi.nlm.nih.gov/42489677/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,41881502,Phase II study of olaparib and durvalumab in patients with metastatic castration-resistant prostate cancer.,2026,10.1136/jitc-2025-014365,https://pubmed.ncbi.nlm.nih.gov/41881502/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,41971422,Case Report: Olaparib combined with temozolomide and atezolizumab in a case of &lt;i&gt;BRCA2&lt;/i&gt;-mutated small-cell transformation of lung adenocarcinoma.,2026,10.3389/fonc.2026.1767999,https://pubmed.ncbi.nlm.nih.gov/41971422/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,41882405,Pembrolizumab and olaparib in homologous-recombination-deficient metastatic pancreatic cancer: the phase 2 POLAR trial.,2026,10.1038/s41591-026-04299-5,https://pubmed.ncbi.nlm.nih.gov/41882405/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42513228,"Breast Cancer: Epidemiology, Molecular Classification, Diagnostics and Evolving Treatment Paradigms.",2026,10.3390/molecules31142551,https://pubmed.ncbi.nlm.nih.gov/42513228/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42923081,"Case Report: Coexpression of somatic EGFR, BRCA1, and BRCA2 mutations in metastatic non-small cell lung cancer. ",2026,10.3389/fonc.2026.1964203,https://pubmed.ncbi.nlm.nih.gov/42923081/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42832307,Non-conventional histologies of prostate cancer: from morphology to biology-driven precision oncology.,2026,10.1093/oncolo/oyag391,https://pubmed.ncbi.nlm.nih.gov/42832307/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,41620448,Sequential platinum and PARP Inhibition enhances PD1 immunotherapy efficacy in murine Brca2 mutated pancreatic cancer.,2026,10.1038/s41598-026-35423-7,https://pubmed.ncbi.nlm.nih.gov/41620448/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42661511,Real-World Outcomes of Olaparib in Japanese Patients With BRCA-Mutated Metastatic Castration-Resistant Prostate Cancer: Exploratory Analysis of BRCA2 Loss and Microsatellite Instability Status.,2026,10.1111/iju.70626,https://pubmed.ncbi.nlm.nih.gov/42661511/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,41970631,From mutation to treatment: The dual role of BRCA1 and BRCA2 in gynecological malignancy development and management a systematic review.,2026,10.1016/j.bbrep.2026.102564,https://pubmed.ncbi.nlm.nih.gov/41970631/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42189716,Molecular architecture of the tumor microenvironment caused by &lt;i&gt;BRCA1&lt;/i&gt; and &lt;i&gt;BRCA2&lt;/i&gt; somatic mutations in human lung adenocarcinoma.,2026,10.7554/elife.110662,https://pubmed.ncbi.nlm.nih.gov/42189716/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,41603275,Engineering Fluoroacetate Dehalogenase by Growth-Based Selections on Non-Natural Organofluorides.,2026,10.1002/anie.202524234,https://pubmed.ncbi.nlm.nih.gov/41603275/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,42054556,Shaping CDK4/6 Inhibitor Resistance: BRCA2 Germline Alterations Bias toward RB1 Inactivation.,2026,10.1158/0008-5472.can-26-1829,https://pubmed.ncbi.nlm.nih.gov/42054556/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,40685286,Novel Therapeutic Strategies for Metastatic Prostate Cancer Care.,2025,10.1016/j.eururo.2025.06.013,https://pubmed.ncbi.nlm.nih.gov/40685286/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRCA2,ENSG00000139618,Unsafe,8589730,The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.,1996,10.1038/ng0396-333,https://pubmed.ncbi.nlm.nih.gov/8589730/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42823668,"BRIP1, a G-quadruplex DNA helicase, protects against AID-induced genomic instability by limiting R-loop accumulation.",2026,10.1186/s10020-026-01627-w,https://pubmed.ncbi.nlm.nih.gov/42823668/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42805912,HBx Enhances the Nrf2/ARE-dependent Antioxidant Response by Promoting Nuclear Export and Downregulation of Bach1.,2026,10.24546/0100505589,https://pubmed.ncbi.nlm.nih.gov/42805912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42029122,YTHDC1 Promotes Triple-Negative Breast Cancer Cell Proliferation and Stemness by Regulating BACH1 mRNA Stability in an m6A-Dependent Manner.,2026,10.1158/1541-7786.mcr-25-0602,https://pubmed.ncbi.nlm.nih.gov/42029122/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,41596682,The Genetic and Molecular Analyses of Rare Candidate Germline &lt;i&gt;BRIP1/FANCJ&lt;/i&gt; Variants Implicated in Hereditary Breast and Ovarian Cancers.,2026,10.3390/ijms27021037,https://pubmed.ncbi.nlm.nih.gov/41596682/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42177227,Nrf2/Bach1-ARE pathway are involved in the ameliorative effects of astaxanthin on D-galactose-induced liver and brain aging and injury.,2026,10.1038/s41598-026-52939-0,https://pubmed.ncbi.nlm.nih.gov/42177227/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,40141297,Tissue-Specific Effects of the DNA Helicase FANCJ/BRIP1/BACH1 on Repeat Expansion in a Mouse Model of the Fragile X-Related Disorders.,2025,10.3390/ijms26062655,https://pubmed.ncbi.nlm.nih.gov/40141297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42510566,Elevated BACH1 Contributes to Mitochondrial Succinylome Remodeling and Trophoblast Bioenergetic Dysfunction in Preeclampsia.,2026,10.3390/antiox15070835,https://pubmed.ncbi.nlm.nih.gov/42510566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42438600,Identification of immunopeptides (pHLA) as candidate therapeutic targets in chondrosarcoma.,2026,10.1016/j.jbo.2026.100780,https://pubmed.ncbi.nlm.nih.gov/42438600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42341848,BACH1 inhibition confers neuroprotection after subarachnoid hemorrhage through activation of the Nrf2 signaling pathway.,2026,10.1016/j.brainresbull.2026.112019,https://pubmed.ncbi.nlm.nih.gov/42341848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42503861,Clinical Relevance of BACH1 Expression in Non-Small Cell Lung Cancer.,2026,10.1002/ijc.70673,https://pubmed.ncbi.nlm.nih.gov/42503861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42269013,BACH1 orchestrates macrophage state transitions to coordinate regenerative inflammation.,2026,10.1093/jimmun/vkag101,https://pubmed.ncbi.nlm.nih.gov/42269013/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,41310217,Synergistic inhibition of CHK1 and MUS81 to combat replication stress resistance in high-risk neuroblastoma.,2025,10.1038/s41598-025-29898-z,https://pubmed.ncbi.nlm.nih.gov/41310217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,41505681,Olaparib Response in a Patient With Platinum-Refractory Germ Cell Tumor Harboring a Somatic &lt;i&gt;BRIP1&lt;/i&gt; Mutation.,2026,10.1200/po-25-00768,https://pubmed.ncbi.nlm.nih.gov/41505681/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42468527,The transcription factor BACH1 couples chromatin priming and repression to enable macrophage plasticity and adaptation.,2026,10.1016/j.immuni.2026.06.022,https://pubmed.ncbi.nlm.nih.gov/42468527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42296473,Renal expression of Bach1 and oxidative stress in chronic kidney disease: evidence from a preclinical model.,2026,10.1590/2175-8239-jbn-2025-0333en,https://pubmed.ncbi.nlm.nih.gov/42296473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,41828629,Role and Mechanism of &lt;i&gt;BRIP1&lt;/i&gt; in Anoikis Resistance of Gastric Cancer.,2026,10.3390/ijms27052409,https://pubmed.ncbi.nlm.nih.gov/41828629/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,38377115,"The DNA helicase FANCJ (BRIP1) functions in double strand break repair processing, but not crossover formation during prophase I of meiosis in male mice.",2024,10.1371/journal.pgen.1011175,https://pubmed.ncbi.nlm.nih.gov/38377115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,41962531,A spinal USP7-Bach1 positive feedback loop drives NOX4-mediated ferroptosis in neuropathic pain.,2026,10.1016/j.redox.2026.104153,https://pubmed.ncbi.nlm.nih.gov/41962531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42801842,Pharmacological inhibition of USP14 attenuates LPS-induced septic myocardial injury by rebalancing Bach1/Nrf2 signalling and mitochondrial quality control.,2026,10.1016/j.intimp.2026.117488,https://pubmed.ncbi.nlm.nih.gov/42801842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42780883,Ferroptosis-driven cell death perpetuates the chronic inflammatory cycle in periodontitis: a single-cell transcriptomic study.,2026,10.3389/fcell.2026.1904996,https://pubmed.ncbi.nlm.nih.gov/42780883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,41740833,BRIP1-mediated RINT1 acetylation and NF-κB activation promote DNA repair and immunosuppressive microenvironment in lung adenocarcinoma.,2026,10.1016/j.canlet.2026.218357,https://pubmed.ncbi.nlm.nih.gov/41740833/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42186808,Hypoxia Upregulation of BACH1 Aggravates Pulmonary Hypertension Through TGFBR2/SMAD Pathways.,2026,10.1161/circulationaha.124.073606,https://pubmed.ncbi.nlm.nih.gov/42186808/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42105598,"Efficacy of olaparib in advanced cancers with somatic or germline mutations in BAP1, BARD1, BRIP1 and PALB2.",2026,10.1016/j.esmoop.2026.107693,https://pubmed.ncbi.nlm.nih.gov/42105598/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,40988318,"Complete remission with olaparib in BRIP1-mutated metastatic high-grade pleomorphic sarcoma: case study and literature review - an example of a genomic profiling-based tumor treatment, in a cancer type with high unmet clinical need.",2025,10.2340/1651-226x.2025.43374,https://pubmed.ncbi.nlm.nih.gov/40988318/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42085862,Development of a high-throughput screening platform for identification of functional BACH1 inhibitors reveals compounds with anti-invasive potential.,2026,10.1016/j.redox.2026.104187,https://pubmed.ncbi.nlm.nih.gov/42085862/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42509749,Targeting the hsa-miR-155-5p-BACH1-MMP-9 Signaling Hub in Lung Cancer: A Novel Anticancer Mechanism of Thymoquinone.,2026,10.3390/biom16070955,https://pubmed.ncbi.nlm.nih.gov/42509749/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,39927196,Effects of hydrazone-based G-quadruplex ligands on &lt;i&gt;FANCJ/BRIP1&lt;/i&gt;-depleted cancer cells and a &lt;i&gt;Caenorhabditis elegans dog-1&lt;sup&gt;-/-&lt;/sup&gt;&lt;/i&gt; strain.,2025,10.1093/narcan/zcaf004,https://pubmed.ncbi.nlm.nih.gov/39927196/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42588616,Upper Tract Urothelial Carcinoma: Molecular Pathogenesis and Current Treatment Strategies-A Narrative Review.,2026,10.3390/cancers18152394,https://pubmed.ncbi.nlm.nih.gov/42588616/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,42178570,A positive feedback loop between BACH1 and IL-1β promotes the progression of HPV-negative head and neck squamous cell carcinoma.,2026,10.1186/s12964-026-02957-2,https://pubmed.ncbi.nlm.nih.gov/42178570/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,41652971,The neuronal ALAS2/5-ala axis mitigates chemotherapy-induced neurotoxicity via the BACH1/NRF2 pathway.,2026,10.1111/bph.70358,https://pubmed.ncbi.nlm.nih.gov/41652971/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,40563308,"Harnessing Antioxidants in Cancer Therapy: Opportunities, Challenges, and Future Directions.",2025,10.3390/antiox14060674,https://pubmed.ncbi.nlm.nih.gov/40563308/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,41606641,BPC157 drives angiogenesis through FBXO22-dependent stabilization of BACH1.,2026,10.1186/s12964-026-02694-6,https://pubmed.ncbi.nlm.nih.gov/41606641/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,40676837,A BACH1 inhibitor ameliorates myocardial infarction and limb ischemia in mice.,2025,10.1016/j.ymthe.2025.07.008,https://pubmed.ncbi.nlm.nih.gov/40676837/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,41070818,"Management of individuals with heterozygous germline pathogenic variants in RAD51C, RAD51D, and BRIP1: A clinical practice resource of the American College of Medical Genetics and Genomics (ACMG).",2025,10.1016/j.gim.2025.101557,https://pubmed.ncbi.nlm.nih.gov/41070818/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,41912851,Enhancement of Rotenone Cytotoxicity in the Presence of Bach1 Inhibitors.,2026,10.1134/s1607672925601817,https://pubmed.ncbi.nlm.nih.gov/41912851/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRIP1,ENSG00000136492,Unsafe,11301010,"BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.",2001,10.1016/s0092-8674(01)00304-x,https://pubmed.ncbi.nlm.nih.gov/11301010/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRME1,ENSG00000132016,Unsafe,39095423,MEILB2-BRME1 forms a V-shaped DNA clamp upon BRCA2-binding in meiotic recombination.,2024,10.1038/s41467-024-50920-x,https://pubmed.ncbi.nlm.nih.gov/39095423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRME1,ENSG00000132016,Unsafe,41655928,The Poly(rC) binding protein 2 is required for spermatogenesis by regulating alternative splicing and mRNA stability.,2026,10.1016/j.ijbiomac.2026.150796,https://pubmed.ncbi.nlm.nih.gov/41655928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRME1,ENSG00000132016,Unsafe,32845237,A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1.,2020,10.7554/elife.56996,https://pubmed.ncbi.nlm.nih.gov/32845237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRME1,ENSG00000132016,Unsafe,32460033,Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic Recombination.,2020,10.1016/j.celrep.2020.107686,https://pubmed.ncbi.nlm.nih.gov/32460033/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRME1,ENSG00000132016,Unsafe,36857322,Therapeutic implications of transcriptomics in head and neck cancer patient-derived xenografts.,2023,10.1371/journal.pone.0282177,https://pubmed.ncbi.nlm.nih.gov/36857322/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRME1,ENSG00000132016,Unsafe,39189159,L3MBTL2 maintains MYCN-amplified neuroblastoma cell proliferation through silencing NRIP3 and BRME1 genes.,2024,10.1111/gtc.13148,https://pubmed.ncbi.nlm.nih.gov/39189159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRME1,ENSG00000132016,Unsafe,37889963,BRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombination.,2023,10.1126/sciadv.adi7352,https://pubmed.ncbi.nlm.nih.gov/37889963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRME1,ENSG00000132016,Unsafe,32345962,The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.,2020,10.1038/s41467-020-15954-x,https://pubmed.ncbi.nlm.nih.gov/32345962/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRME1,ENSG00000132016,Unsafe,37806621,Liver transcriptome profiles of dairy cows with different serum metabotypes.,2024,10.3168/jds.2023-23572,https://pubmed.ncbi.nlm.nih.gov/37806621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRME1,ENSG00000132016,Unsafe,33712015,Identification of four key prognostic genes and three potential drugs in human papillomavirus negative head and neck squamous cell carcinoma.,2021,10.1186/s12935-021-01863-6,https://pubmed.ncbi.nlm.nih.gov/33712015/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRME1,ENSG00000132016,Unsafe,36686818,Alternative splicing event associated with immunological features in bladder cancer.,2022,10.3389/fonc.2022.966088,https://pubmed.ncbi.nlm.nih.gov/36686818/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRME1,ENSG00000132016,Unsafe,34755660,[Peripheral blood EMR3 gene methylation level is correlated with breast cancer in Chinese women].,2021,10.12122/j.issn.1673-4254.2021.10.03,https://pubmed.ncbi.nlm.nih.gov/34755660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRME1,ENSG00000132016,Unsafe,31456134,Transcriptome sequencing profiles of cervical cancer tissues and SiHa cells.,2020,10.1007/s10142-019-00706-y,https://pubmed.ncbi.nlm.nih.gov/31456134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,41160232,Multi-omics reveals cross-tissue regulatory mechanisms of autism risk loci via gut microbiota-immunity-brain axis.,2025,10.1186/s13568-025-01969-4,https://pubmed.ncbi.nlm.nih.gov/41160232/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,42680906,Whole-exome sequencing in individuals with obsessive-compulsive disorder and chronic tic disorders identifies 36 large-effect risk genes.,2026,10.1038/s41593-026-02419-5,https://pubmed.ncbi.nlm.nih.gov/42680906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,42413388,"Integrative multi-omics analysis identifies a mitochondrial dysfunction-associated diagnostic signature, molecular subtypes, and drug repurposing candidates for keloid disease.",2026,10.1016/j.burns.2026.108118,https://pubmed.ncbi.nlm.nih.gov/42413388/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,36289231,Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome.,2022,10.1038/s41467-022-34200-0,https://pubmed.ncbi.nlm.nih.gov/36289231/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,37985858,BRWD1 orchestrates small pre-B cell chromatin topology by converting static to dynamic cohesin.,2024,10.1038/s41590-023-01666-z,https://pubmed.ncbi.nlm.nih.gov/37985858/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,40325078,DCMS analysis revealed differential selection signatures in the transboundary Sahiwal cattle for major economic traits.,2025,10.1038/s41598-025-93021-5,https://pubmed.ncbi.nlm.nih.gov/40325078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,40000848,Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred rats.,2025,10.1038/s41380-025-02922-4,https://pubmed.ncbi.nlm.nih.gov/40000848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,34473250,Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis.,2021,10.1242/dev.198374,https://pubmed.ncbi.nlm.nih.gov/34473250/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,36035305,Exploring Early Physical Examination Diagnostic Biomarkers for Alzheimer's Disease Based on Least Absolute Shrinkage and Selection Operator.,2022,10.1155/2022/3039248,https://pubmed.ncbi.nlm.nih.gov/36035305/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,34082824,Exosomal circ-BRWD1 contributes to osteoarthritis development through the modulation of miR-1277/TRAF6 axis.,2021,10.1186/s13075-021-02541-8,https://pubmed.ncbi.nlm.nih.gov/34082824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,30250168,BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis.,2018,10.1038/s41467-018-06165-6,https://pubmed.ncbi.nlm.nih.gov/30250168/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,39210813,"Genome-wide copy number variation regions in indigenous (Bos indicus) cattle breeds of Tamil Nadu, India.",2025,10.5713/ab.23.0525,https://pubmed.ncbi.nlm.nih.gov/39210813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,33389130,Bi-allelic BRWD1 variants cause male infertility with asthenoteratozoospermia and likely primary ciliary dyskinesia.,2021,10.1007/s00439-020-02241-4,https://pubmed.ncbi.nlm.nih.gov/33389130/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,38918649,A Systematic Review of the Prevalence of Germline BRCA mutations in North Asia Breast Cancer Patients.,2024,10.31557/apjcp.2024.25.6.1891,https://pubmed.ncbi.nlm.nih.gov/38918649/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,31989994,Related Network and Differential Expression Analyses Identify Nuclear Genes and Pathways in the Hippocampus of Alzheimer Disease.,2020,10.12659/msm.919311,https://pubmed.ncbi.nlm.nih.gov/31989994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,25547156,Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability.,2015,10.1083/jcb.201404109,https://pubmed.ncbi.nlm.nih.gov/25547156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,35490316,Identification of Six Novel Prognostic Gene Signatures as Potential Biomarkers in Small Cell Lung Cancer.,2023,10.2174/1386207325666220427121619,https://pubmed.ncbi.nlm.nih.gov/35490316/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,30536307,MALAT1 promotes cisplatin resistance in cervical cancer by activating the PI3K/AKT pathway.,2018,10.26355/eurrev_201811_16382,https://pubmed.ncbi.nlm.nih.gov/30536307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,36575195,Phase I study of LZM005 in patients with HER2-positive metastatic breast cancer.,2022,10.1038/s41523-022-00501-2,https://pubmed.ncbi.nlm.nih.gov/36575195/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,31914881,"LncRNA XIST serves as a ceRNA to regulate the expression of ASF1A, BRWD1M, and PFKFB2 in kidney transplant acute kidney injury via sponging hsa-miR-212-3p and hsa-miR-122-5p.",2020,10.1080/15384101.2019.1707454,https://pubmed.ncbi.nlm.nih.gov/31914881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,26301565,Histone reader BRWD1 targets and restricts recombination to the Igk locus.,2015,10.1038/ni.3249,https://pubmed.ncbi.nlm.nih.gov/26301565/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,20014019,Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease.,2010,10.1002/ibd.21174,https://pubmed.ncbi.nlm.nih.gov/20014019/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BRWD1,ENSG00000185658,Unsafe,12359327,"Characterisation and expression analysis of the WDR9 gene, located in the Down critical region-2 of the human chromosome 21.",2002,10.1016/s0167-4781(02)00421-9,https://pubmed.ncbi.nlm.nih.gov/12359327/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSPH1,ENSG00000188334,Unsafe,32488144,Epididymal proteins Binder of SPerm Homologs 1 and 2 (BSPH1/2) are dispensable for male fertility and sperm motility in mice.,2020,10.1038/s41598-020-66017-6,https://pubmed.ncbi.nlm.nih.gov/32488144/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSPH1,ENSG00000188334,Unsafe,29969530,CRISPR-Cas9-mediated mutation revealed BSPH2 protein is dispensable for male fertility.,2018,10.1002/mrd.23039,https://pubmed.ncbi.nlm.nih.gov/29969530/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSPH1,ENSG00000188334,Unsafe,35131677,Antioxidant properties and transcriptome of cauda epididymis with different levels of fertility in Hu lambs.,2022,10.1016/j.theriogenology.2022.01.035,https://pubmed.ncbi.nlm.nih.gov/35131677/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSPH1,ENSG00000188334,Unsafe,26333091,New Insights into the Phylogeny and Gene Context Analysis of Binder of Sperm Proteins (BSPs).,2015,10.1371/journal.pone.0137008,https://pubmed.ncbi.nlm.nih.gov/26333091/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSPH1,ENSG00000188334,Unsafe,19091820,"Recombinant expression and affinity purification of a novel epididymal human sperm-binding protein, BSPH1.",2009,10.1093/molehr/gan077,https://pubmed.ncbi.nlm.nih.gov/19091820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSPH1,ENSG00000188334,Unsafe,24307707,Murine Binder of SPerm homolog 2 (BSPH2): the black sheep of the BSP superfamily.,2014,10.1095/biolreprod.113.114272,https://pubmed.ncbi.nlm.nih.gov/24307707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSPH1,ENSG00000188334,Unsafe,25698855,Genetic characterization of Fasciola gigantica from different geographical regions of India by ribosomal DNA markers.,2015,10.1007/s12639-013-0276-7,https://pubmed.ncbi.nlm.nih.gov/25698855/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BSPH1,ENSG00000188334,Unsafe,17085770,Genomic structure and tissue-specific expression of human and mouse genes encoding homologues of the major bovine seminal plasma proteins.,2007,10.1093/molehr/gal098,https://pubmed.ncbi.nlm.nih.gov/17085770/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,41828362,Genetic Mutations and Non-Genomic Dysregulation in Human Preimplantation Embryo Arrest.,2026,10.3390/ijms27052135,https://pubmed.ncbi.nlm.nih.gov/41828362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,42278318,When Fertilization Is Not Enough: Maternal-Zygotic Transition as a Determinant of Embryo Competence in IVF.,2026,10.3390/ijms27114787,https://pubmed.ncbi.nlm.nih.gov/42278318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,41231099,Autophagy regulates the maternal-to-zygotic transition through MAP1LC3B-mediated maternal mRNA decay.,2026,10.1080/15548627.2025.2589911,https://pubmed.ncbi.nlm.nih.gov/41231099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,36880525,Bioinformatic analysis of the clinicopathological and prognostic significance of oocyte-arresting BTG4 mRNA expression in gynecological cancers.,2023,10.1080/01443615.2023.2182672,https://pubmed.ncbi.nlm.nih.gov/36880525/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,41898836,Transcriptional Modulation of Infertility-Associated Genes Following &lt;i&gt;Chlamydia trachomatis&lt;/i&gt; Infection in Human Fallopian Tube Mesenchymal Cells: In Silico Study.,2026,10.3390/genes17030302,https://pubmed.ncbi.nlm.nih.gov/41898836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,40265969,PABPN1 Couples the Polyadenylation and Translation of Maternal Transcripts to Mouse Oocyte Meiotic Maturation.,2025,10.1002/advs.202500048,https://pubmed.ncbi.nlm.nih.gov/40265969/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,38956014,Maternal mRNA deadenylation is defective in in vitro matured mouse and human oocytes.,2024,10.1038/s41467-024-49695-y,https://pubmed.ncbi.nlm.nih.gov/38956014/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,38308190,Zygotic Splicing Activation of the Transcriptome is a Crucial Aspect of Maternal-to-Zygotic Transition and Required for the Conversion from Totipotency to Pluripotency.,2024,10.1002/advs.202308496,https://pubmed.ncbi.nlm.nih.gov/38308190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,42070745,Role of zygotic arrest genes in female meiosis and early embryonic development.,2026,10.1016/j.ydbio.2026.04.019,https://pubmed.ncbi.nlm.nih.gov/42070745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,38062199,A pan-cancer analysis of anti-proliferative protein family genes for therapeutic targets in cancer.,2023,10.1038/s41598-023-48961-1,https://pubmed.ncbi.nlm.nih.gov/38062199/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,40122822,BDNF secreted by mesenchymal stem cells improves aged oocyte quality and development potential by activating the ERK1/2 pathway.,2025,10.1186/s12964-025-02137-8,https://pubmed.ncbi.nlm.nih.gov/40122822/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,36471203,A novel homozygous C-terminal deletion in BTG4 causes zygotic cleavage failure and female infertility.,2023,10.1007/s10815-022-02664-0,https://pubmed.ncbi.nlm.nih.gov/36471203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,37874431,Differential expression of TOB/BTG family members in patients with plaque psoriasis: cross-sectional study.,2024,10.1007/s12026-023-09427-8,https://pubmed.ncbi.nlm.nih.gov/37874431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,37889087,LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.,2023,10.1093/nar/gkad919,https://pubmed.ncbi.nlm.nih.gov/37889087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,32093041,BTG4 is A Novel p53 Target Gene That Inhibits Cell Growth and Induces Apoptosis.,2020,10.3390/genes11020217,https://pubmed.ncbi.nlm.nih.gov/32093041/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,37102425,The MIR34B/C genomic region contains multiple potential regulators of multiciliogenesis.,2023,10.1002/1873-3468.14630,https://pubmed.ncbi.nlm.nih.gov/37102425/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,36927412,RNA binding proteins are potential novel biomarkers of egg quality in yellow catfish.,2023,10.1186/s12864-023-09220-9,https://pubmed.ncbi.nlm.nih.gov/36927412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,39358566,Comprehensive analysis of chromosomal breakpoints and candidate genes associated with male infertility: insights from cytogenetic studies and expression analyses.,2024,10.1007/s00335-024-10074-z,https://pubmed.ncbi.nlm.nih.gov/39358566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,36827867,mRNA 3' -UTR-mediate translational control through PAS and CPE in sheep oocyte.,2023,10.1016/j.theriogenology.2022.11.023,https://pubmed.ncbi.nlm.nih.gov/36827867/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,34647228,A novel homozygous missense variant in BTG4 causes zygotic cleavage failure and female infertility.,2021,10.1007/s10815-021-02340-9,https://pubmed.ncbi.nlm.nih.gov/34647228/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,33924908,Comprehensive Transcriptome Analysis of mRNA Expression Patterns of Early Embryo Development in Goat under Hypoxic and Normoxic Conditions.,2021,10.3390/biology10050381,https://pubmed.ncbi.nlm.nih.gov/33924908/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,33247598,Expression of TOB/BTG family members in patients with inflammatory bowel disease.,2021,10.1111/sji.13004,https://pubmed.ncbi.nlm.nih.gov/33247598/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,34257377,Single cell RNA-seq reveals genes vital to in vitro fertilized embryos and parthenotes in pigs.,2021,10.1038/s41598-021-93904-3,https://pubmed.ncbi.nlm.nih.gov/34257377/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,34117263,Genome-wide DNA methylation analysis on C-reactive protein among Ghanaians suggests molecular links to the emerging risk of cardiovascular diseases.,2021,10.1038/s41525-021-00213-9,https://pubmed.ncbi.nlm.nih.gov/34117263/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,23236473,The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.,2012,10.1371/journal.pone.0051331,https://pubmed.ncbi.nlm.nih.gov/23236473/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,31811028,NURR1 and ERR1 Modulate the Expression of Genes of a DRD2 Coexpression Network Enriched for Schizophrenia Risk.,2020,10.1523/jneurosci.0786-19.2019,https://pubmed.ncbi.nlm.nih.gov/31811028/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,31513655,Comparative analysis of postural control and vertical jump performance between three different measurement devices.,2019,10.1371/journal.pone.0222502,https://pubmed.ncbi.nlm.nih.gov/31513655/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,28241740,Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells.,2017,10.1186/s12860-017-0130-3,https://pubmed.ncbi.nlm.nih.gov/28241740/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,11429045,"Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex.",2001,10.1111/j.1349-7006.2001.tb01135.x,https://pubmed.ncbi.nlm.nih.gov/11429045/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BTG4,ENSG00000137707,Unsafe,32502391,Homozygous Mutations in BTG4 Cause Zygotic Cleavage Failure and Female Infertility.,2020,10.1016/j.ajhg.2020.05.010,https://pubmed.ncbi.nlm.nih.gov/32502391/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,42602342,BUB1 regulates cell proliferation and apoptosis in cervical cancer by AKT signaling and autophagosome-lysosome fusion via ACTN1.,2026,10.1016/j.isci.2026.117040,https://pubmed.ncbi.nlm.nih.gov/42602342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,42338979,BUB1 in cancer genetics and oncogenomics: from chromosomal instability to therapeutic vulnerabilities.,2026,10.3389/fgene.2026.1832358,https://pubmed.ncbi.nlm.nih.gov/42338979/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,42792682,"BUB1 and CDK4/6 Dual Inhibition Increases Radiation Sensitivity in Glioblastoma, Lung Cancer, and Triple-Negative Breast Cancer.",2026,10.3390/biomedicines14091940,https://pubmed.ncbi.nlm.nih.gov/42792682/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,41673219,BUB1 promotes cell stem-like properties and serves as a diagnostic biomarker for lung cancer.,2026,10.1038/s41598-026-38997-4,https://pubmed.ncbi.nlm.nih.gov/41673219/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,41545643,Identification of hub genes and construction of a survival prediction model for patients with nasopharyngeal carcinoma.,2026,10.1038/s41598-026-36395-4,https://pubmed.ncbi.nlm.nih.gov/41545643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,42496474,Epilepsy and Intellectual Disability in a Boy with a 2q13 Microdeletion Affecting the &lt;i&gt;BUB1&lt;/i&gt; Gene.,2026,10.3390/pediatric18040096,https://pubmed.ncbi.nlm.nih.gov/42496474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,41552303,Expression and clinical significance of BUB1 in esophageal cancer.,2025,10.62347/egdo2592,https://pubmed.ncbi.nlm.nih.gov/41552303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,41618008,Exploring the mechanism and therapeutic potential of BUB1 in regulating esophageal cancer progression based on 5-FU target prediction.,2026,10.1007/s12672-026-04486-3,https://pubmed.ncbi.nlm.nih.gov/41618008/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,42106529,Identification of biomarkers associated with diagnosis of gastroesophageal junction adenocarcinoma and their correlation with immune infiltration.,2026,10.1007/s12672-026-05067-0,https://pubmed.ncbi.nlm.nih.gov/42106529/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,42445139,Identification and validation of novel candidate genes with diagnostic value for sepsis via weighted gene co-expression network analysis.,2026,10.3389/fmed.2026.1817161,https://pubmed.ncbi.nlm.nih.gov/42445139/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,42014906,BUB1 as a candidate non-oncogene addiction vulnerability in metastatic phaeochromocytoma/paraganglioma.,2026,10.1038/s41598-026-49408-z,https://pubmed.ncbi.nlm.nih.gov/42014906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,41704471,BUB1 promotes lung adenocarcinoma progression by regulating STAT3/GPX4-mediated ferroptosis.,2025,10.3389/fonc.2025.1745238,https://pubmed.ncbi.nlm.nih.gov/41704471/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,41398961,hsa-let-7b-5p-associated BUB1/TMPO-AS1 ceRNA axis identified as a potential biomarker in lung adenocarcinoma.,2025,10.1186/s13008-025-00173-x,https://pubmed.ncbi.nlm.nih.gov/41398961/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,41257608,"Nitidine chloride inhibits colorectal cancer by targeting BUB1: mechanistic insights from molecular dynamics simulation, spatial transcriptomics, and single-cell RNA sequencing.",2025,10.1186/s12876-025-04423-8,https://pubmed.ncbi.nlm.nih.gov/41257608/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,42205842,Identification and preliminary clinical validation of type 2 diabetes signature genes through machine learning analysis of scRNA-seq data.,2026,10.3389/fmed.2026.1801737,https://pubmed.ncbi.nlm.nih.gov/42205842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,41943830,Mechanistic Insights into the FOXM1/BUB1 axis-Mediated Oncogenic Signaling in Hepatocellular Carcinoma.,2026,10.7150/ijbs.125454,https://pubmed.ncbi.nlm.nih.gov/41943830/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,40723917,"BUB1 an Overexpressed Kinase in Sarcoma: Finding New Target Therapy for Osteosarcoma, Liposarcoma, Synovial Sarcoma, and Leiomyosarcoma.",2025,10.3390/biom15071046,https://pubmed.ncbi.nlm.nih.gov/40723917/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,42483440,Unveiling immune-related gene signatures in triple negative breast cancer through integrated transcriptomic analysis.,2026,10.37796/2211-8039.1708,https://pubmed.ncbi.nlm.nih.gov/42483440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,41699006,"Dysregulated expression of cell cycle regulators CDC20, PLK1, BUB1, CDC45, CDCA5 in pancreatic ductal adenocarcinoma.",2026,10.1038/s41598-026-37399-w,https://pubmed.ncbi.nlm.nih.gov/41699006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,41486123,Transcriptomics identified crucial candidate genes and pathways regulating early testicular development of drakes in the hypothalamic-pituitary-gonadal/thyroid axes.,2026,10.1186/s12864-025-12505-w,https://pubmed.ncbi.nlm.nih.gov/41486123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,42756106,Real-world insights into genomic reprogramming during CAR-T cell manufacturing in India.,2026,10.3389/fimmu.2026.1912690,https://pubmed.ncbi.nlm.nih.gov/42756106/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,41846061,Immunoregulatory kinases and T-cell pathways in DNA-damage response and autoimmune inflammation: Emerging roles of BUB1 and IGFL2.,2026,10.1016/j.intimp.2026.116509,https://pubmed.ncbi.nlm.nih.gov/41846061/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,42164122,23-hydroxybetulinic acid induces cell cycle arrest in esophageal cancer cells via the BUB1/STAT3 signaling pathway.,2026,10.3389/fonc.2026.1804674,https://pubmed.ncbi.nlm.nih.gov/42164122/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,40069598,BUB1 serves as a biomarker for poor prognosis in liver hepatocellular carcinoma.,2025,10.1186/s12865-025-00698-4,https://pubmed.ncbi.nlm.nih.gov/40069598/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,40859340,BUB1-based risk model predicts prostate cancer prognosis and reveals therapeutic vulnerabilities.,2025,10.1186/s40001-025-03098-x,https://pubmed.ncbi.nlm.nih.gov/40859340/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,40779648,A noncanonical cytoplasmic role for BUB1 in restraining DNA damage-induced dsRNA accumulation and sensing within stress granules.,2025,10.1126/sciimmunol.adq2055,https://pubmed.ncbi.nlm.nih.gov/40779648/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,40081509,BUB1-deficiency suppresses kidney renal clear cell carcinoma progression via the PI3K/Akt pathway: A bioinformatics-oriented validating study.,2025,10.1016/j.mcp.2025.102024,https://pubmed.ncbi.nlm.nih.gov/40081509/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,42314223,Response of MRC-5 human lung fibroblasts to FLASH and conventional radiotherapy: A study on differential DNA damage and transcriptomic response.,2026,10.1016/j.compbiolchem.2026.109198,https://pubmed.ncbi.nlm.nih.gov/42314223/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1,ENSG00000169679,Unsafe,39430818,BUB1 as a novel marker for predicting the immunotherapy efficacy and prognosis of breast cancer.,2024,10.21037/tcr-24-704,https://pubmed.ncbi.nlm.nih.gov/39430818/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,42434306,Functional and clinical evidence for two novel heterozygous &lt;i&gt;BUB1B&lt;/i&gt; variants and their value in precision genetic counseling for recurrent pregnancy loss.,2026,10.3389/fendo.2026.1838559,https://pubmed.ncbi.nlm.nih.gov/42434306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,42437282,An SSK1-loaded decellularized annulus fibrosus matrix-based PD hydrogel alleviates intervertebral disc degeneration through modulation of NF-κB signaling and ferroptosis.,2026,10.1016/j.jot.2026.101168,https://pubmed.ncbi.nlm.nih.gov/42437282/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,41972901,Targeted senotherapy improves electrographic and behavioral outcomes in a mouse model of temporal lobe epilepsy.,2026,10.1002/epi.70226,https://pubmed.ncbi.nlm.nih.gov/41972901/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,42757823,BUB1B Mitotic Kinase Dependency Reveals CENP-E Inhibition as a Tractable Approach for Castration and Enzalutamide Resistant Prostate Cancer.,2026,10.1158/0008-5472.can-26-0874,https://pubmed.ncbi.nlm.nih.gov/42757823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,40055864,BubR1 Controls Heart Development by Promoting Expression of Cardiogenesis Regulators.,2025,10.1161/jaha.124.038286,https://pubmed.ncbi.nlm.nih.gov/40055864/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,41526964,Multi-omics analysis identifies BUB1B as a cell cycle-related driver of bladder cancer progression.,2026,10.1186/s12957-025-04175-5,https://pubmed.ncbi.nlm.nih.gov/41526964/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,41202471,β-galactosidase-targeted senolytic prodrug ameliorates preclinical models of post-traumatic osteoarthritis.,2025,10.1016/j.ebiom.2025.106015,https://pubmed.ncbi.nlm.nih.gov/41202471/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,41545558,Translational evaluation of BUB1B as a precision medicine biomarker for hepatocellular carcinoma.,2026,10.1038/s41598-026-36364-x,https://pubmed.ncbi.nlm.nih.gov/41545558/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,42295646,BUB1B is a novel prognostic-related biomarker and correlated with immune infiltrates in lung adenocarcinoma.,2026,10.1007/s12094-026-04454-x,https://pubmed.ncbi.nlm.nih.gov/42295646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,41163302,BUB1B Promotes Ovarian Cancer Cell Proliferation and Metastasis by Activating the Wnt/β-Catenin Pathway.,2025,10.1002/cam4.71311,https://pubmed.ncbi.nlm.nih.gov/41163302/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,42365339,Identification and validation of stemness-associated hub genes in cervical cancer: a bioinformatics and experimental study.,2026,10.1186/s12957-026-04472-7,https://pubmed.ncbi.nlm.nih.gov/42365339/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,40910254,BUB1B promotes homologous recombination‑mediated DNA damage repair in breast cancer cells through the PI3K/AKT signaling pathway.,2025,10.3892/or.2025.8980,https://pubmed.ncbi.nlm.nih.gov/40910254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,42647139,Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small Cell Lung Cancer.,2026,10.1158/2767-9764.crc-26-0560,https://pubmed.ncbi.nlm.nih.gov/42647139/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,39014450,BUB1B monoallelic germline variants contribute to prostate cancer predisposition by triggering chromosomal instability.,2024,10.1186/s12929-024-01056-z,https://pubmed.ncbi.nlm.nih.gov/39014450/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,42483440,Unveiling immune-related gene signatures in triple negative breast cancer through integrated transcriptomic analysis.,2026,10.37796/2211-8039.1708,https://pubmed.ncbi.nlm.nih.gov/42483440/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,40857057,KIFC1 Overexpression Promotes Pancreatic Carcinoma Progression via Stabilising BUB1B.,2025,10.1111/jcmm.70767,https://pubmed.ncbi.nlm.nih.gov/40857057/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,41378098,"Radiotherapy and precision medicine's role in molecular alterations during chromosomal division: The influence of &lt;i&gt;MB, TP53, CENPA, BUB1B&lt;/i&gt;, &lt;i&gt;MAD2L1&lt;/i&gt;, &lt;i&gt;ZWINT&lt;/i&gt; expression and noncoding RNAs in oral cancer.",2025,10.1016/j.bbrep.2025.102376,https://pubmed.ncbi.nlm.nih.gov/41378098/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,42477419,BubR1 TPR domain supports the mitotic checkpoint by promoting MCC formation and MCC-APC/C interaction.,2026,10.1038/s42003-026-10384-9,https://pubmed.ncbi.nlm.nih.gov/42477419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,40607964,BubR1 Insufficiency Drives Transcriptomic Alterations and Pathology Associated With Cardiac Aging and Heart Failure.,2025,10.1111/acel.70160,https://pubmed.ncbi.nlm.nih.gov/40607964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,42667124,An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development.,2026,10.1096/fj.202600627rr,https://pubmed.ncbi.nlm.nih.gov/42667124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,41578708,Targeting the FOXM1/BUB1B signaling network in multiple myeloma: mechanistic insights and therapeutic potential.,2026,10.1080/10428194.2025.2612628,https://pubmed.ncbi.nlm.nih.gov/41578708/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,40076684,A Comprehensive Analysis Revealing BUB1B as a Potential Prognostic and Immunological Biomarker in Lung Adenocarcinoma.,2025,10.3390/ijms26052061,https://pubmed.ncbi.nlm.nih.gov/40076684/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,41875331,Design and Optimization of Lysosome-Targeted β-Galactoside Senolytic Prodrugs: Harnessing the Aromatic Ring of Self-Immolative Linkers.,2026,10.1021/acs.jmedchem.5c01922,https://pubmed.ncbi.nlm.nih.gov/41875331/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,42551718,An oxidative stress - and immunotherapy-related six-gene signature defines immune subtypes and predicts prognosis and immunotherapy response in hepatocellular carcinoma.,2026,10.1016/j.gene.2026.150335,https://pubmed.ncbi.nlm.nih.gov/42551718/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,41533300,The MAD2L1-FOXM1 axis negatively regulates CD4⁺ T cell and macrophages infiltration in lung adenocarcinoma.,2026,10.1007/s12672-025-04360-8,https://pubmed.ncbi.nlm.nih.gov/41533300/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,40357287,DNA methylation-driven genes in hepatocellular carcinoma patients: insights into immune infiltration and prognostic implications.,2025,10.3389/fmed.2025.1520380,https://pubmed.ncbi.nlm.nih.gov/40357287/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,39048649,Correlation of BUB1 and BUB1B with the development and prognosis of endometrial cancer.,2024,10.1038/s41598-024-67528-2,https://pubmed.ncbi.nlm.nih.gov/39048649/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,41285333,"TOP2A, BUB1B, CENPF, KIF15 and MELK: Key senescence-related genes linked to prognosis and immune infiltration in lung adenocarcinoma.",2026,10.1016/j.ijbiomac.2025.149215,https://pubmed.ncbi.nlm.nih.gov/41285333/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
BUB1B,ENSG00000156970,Unsafe,10593653,BUBR1 phosphorylation is regulated during mitotic checkpoint activation.,1999,,https://pubmed.ncbi.nlm.nih.gov/10593653/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C10orf67,ENSG00000179133,Unsafe,40795059,Tracing the Genetic Heritage of the Kirgiz People: Dual-Wave Admixture and Ancestry-Biased Adaptation.,2025,10.1093/molbev/msaf196,https://pubmed.ncbi.nlm.nih.gov/40795059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C10orf67,ENSG00000179133,Unsafe,34692117,Convergent genomic signatures of high-altitude adaptation among domestic mammals.,2020,10.1093/nsr/nwz213,https://pubmed.ncbi.nlm.nih.gov/34692117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C10orf67,ENSG00000179133,Unsafe,27812135,Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.,2016,10.1371/journal.pone.0165420,https://pubmed.ncbi.nlm.nih.gov/27812135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C10orf67,ENSG00000179133,Unsafe,22972473,Fine-mapping in African-American women confirms the importance of the 10p12 locus to sarcoidosis.,2012,10.1038/gene.2012.42,https://pubmed.ncbi.nlm.nih.gov/22972473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C11orf65,ENSG00000166323,Unsafe,32408300,"Genomic Profiling of Stage II Colorectal Cancer Identifies Candidate Genes Associated with Recurrence-Free Survival, Tumor Location, and Differentiation Grade.",2020,10.1159/000507118,https://pubmed.ncbi.nlm.nih.gov/32408300/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C11orf65,ENSG00000166323,Unsafe,32391418,Genomic variation as a marker of response to neoadjuvant therapy in locally advanced rectal cancer.,2020,10.1080/23723556.2020.1716618,https://pubmed.ncbi.nlm.nih.gov/32391418/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C11orf65,ENSG00000166323,Unsafe,32425970,Exome Sequencing Analysis Identifies Rare Variants in &lt;i&gt;ATM&lt;/i&gt; and &lt;i&gt;RPL8&lt;/i&gt; That Are Associated With Shorter Telomere Length.,2020,10.3389/fgene.2020.00337,https://pubmed.ncbi.nlm.nih.gov/32425970/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C11orf65,ENSG00000166323,Unsafe,24741944,[Potential sensitivity to metformin of the diabetics suffering and not suffering with cancer: a pharmacogenetic study].,2013,10.15690/vramn.v68i12.861,https://pubmed.ncbi.nlm.nih.gov/24741944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C11orf65,ENSG00000166323,Unsafe,32407269,Pharmacogenetic Evaluation of Metformin and Sulphonylurea Response in Mexican Mestizos with Type 2 Diabetes.,2020,10.2174/1389200221666200514125443,https://pubmed.ncbi.nlm.nih.gov/32407269/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C11orf65,ENSG00000166323,Unsafe,30059978,A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission.,2018,10.1210/en.2018-00426,https://pubmed.ncbi.nlm.nih.gov/30059978/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C11orf71,ENSG00000180425,Unsafe,34465742,Genome-wide association study of COVID-19 severity among the Chinese population.,2021,10.1038/s41421-021-00318-6,https://pubmed.ncbi.nlm.nih.gov/34465742/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C11orf96,ENSG00000187479,Unsafe,39061769,In Vitro Bioassay for Damage-Associated Molecular Patterns Arising from Injured Oral Cells.,2024,10.3390/bioengineering11070687,https://pubmed.ncbi.nlm.nih.gov/39061769/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C11orf96,ENSG00000187479,Unsafe,38003371,Bone Allograft Acid Lysates Change the Genetic Signature of Gingival Fibroblasts.,2023,10.3390/ijms242216181,https://pubmed.ncbi.nlm.nih.gov/38003371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C11orf96,ENSG00000187479,Unsafe,39580900,"Characterization of the C5H11ORF96 gene in chickens: cloning, tissue distribution and investigation of its potential function in stress response regulation.",2025,10.1016/j.psj.2024.104500,https://pubmed.ncbi.nlm.nih.gov/39580900/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C11orf96,ENSG00000187479,Unsafe,35538492,"Molecular cloning, characterization, and functional analysis of the uncharacterized C11orf96 gene.",2022,10.1186/s12917-022-03224-5,https://pubmed.ncbi.nlm.nih.gov/35538492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C11orf96,ENSG00000187479,Unsafe,36647876,Integrative analyses of radiation-related genes and biomarkers associated with breast cancer.,2023,10.26355/eurrev_202301_30907,https://pubmed.ncbi.nlm.nih.gov/36647876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C11orf96,ENSG00000187479,Unsafe,36468438,An RNA-seq transcriptome analysis for investigating the anti-lung cancer activity of medicinal Cuscuta chinensis Lam plant.,2023,10.1017/s0007114522003865,https://pubmed.ncbi.nlm.nih.gov/36468438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C11orf96,ENSG00000187479,Unsafe,30175151,Bioinformatics Analysis Reveals Most Prominent Gene Candidates to Distinguish Colorectal Adenoma from Adenocarcinoma.,2018,10.1155/2018/9416515,https://pubmed.ncbi.nlm.nih.gov/30175151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C12orf42,ENSG00000179088,Unsafe,35985684,Fusion of High Mobility Group AT-hook 2 Gene (HMGA2) With the Chromosome 12 Open Reading Frame 42 Gene (C12orf42) in an Aggressive Angiomyxoma With del(12)(q14q23) as the Sole Cytogenetic Anomaly.,2022,10.21873/cgp.20342,https://pubmed.ncbi.nlm.nih.gov/35985684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C12orf42,ENSG00000179088,Unsafe,32256782,Identification of DNA methylation-driven genes by integrative analysis of DNA methylation and transcriptome data in pancreatic adenocarcinoma.,2020,10.3892/etm.2020.8554,https://pubmed.ncbi.nlm.nih.gov/32256782/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C12orf42,ENSG00000179088,Unsafe,33833773,Aberrantly DNA Methylated-Differentially Expressed Genes in Pancreatic Cancer Through an Integrated Bioinformatics Approach.,2021,10.3389/fgene.2021.583568,https://pubmed.ncbi.nlm.nih.gov/33833773/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C12orf42,ENSG00000179088,Unsafe,32764425,Discovery of Molecular DNA Methylation-Based Biomarkers through Genome-Wide Analysis of Response Patterns to BCG for Bladder Cancer.,2020,10.3390/cells9081839,https://pubmed.ncbi.nlm.nih.gov/32764425/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C12orf42,ENSG00000179088,Unsafe,20659153,Molecular characterization of a novel chromosomal translocation t(12;14)(q23;q11.2) in T-lymphoblastic lymphoma between the T-cell receptor delta-deleting elements (TRDREC and TRAJ61) and the hypothetical gene C12orf42.,2010,10.1111/j.1600-0609.2010.01508.x,https://pubmed.ncbi.nlm.nih.gov/20659153/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C12orf54,ENSG00000177627,Unsafe,37227814,Identification and validation of diagnostic signature genes in non-obstructive azoospermia by machine learning.,2023,10.18632/aging.204749,https://pubmed.ncbi.nlm.nih.gov/37227814/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C12orf54,ENSG00000177627,Unsafe,38077447,Identification of novel biomarkers in obstructive sleep apnea &lt;i&gt;via&lt;/i&gt; integrated bioinformatics analysis and experimental validation.,2023,10.7717/peerj.16608,https://pubmed.ncbi.nlm.nih.gov/38077447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C12orf54,ENSG00000177627,Unsafe,30429015,Detection of autoantibodies against cancer-testis antigens in non-small cell lung cancer.,2018,10.1016/j.lungcan.2018.09.012,https://pubmed.ncbi.nlm.nih.gov/30429015/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C12orf56,ENSG00000185306,Unsafe,39120060,Key genes and immune infiltration patterns and the clinical implications in psoriasis patients.,2024,10.1111/srt.13889,https://pubmed.ncbi.nlm.nih.gov/39120060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C12orf56,ENSG00000185306,Unsafe,21310917,Copy number variations and primary open-angle glaucoma.,2011,10.1167/iovs.10-5606,https://pubmed.ncbi.nlm.nih.gov/21310917/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C12orf60,ENSG00000182993,Unsafe,26189108,Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients.,2015,10.1016/j.leukres.2015.06.005,https://pubmed.ncbi.nlm.nih.gov/26189108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C14orf39,ENSG00000179008,Unsafe,41565805,Common variation in meiosis genes shapes human recombination and aneuploidy.,2026,10.1038/s41586-025-09964-2,https://pubmed.ncbi.nlm.nih.gov/41565805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C14orf39,ENSG00000179008,Unsafe,41112153,N-carbamylglutamate supplementation improves laying performance of layers by regulating hypothalamic-pituitary-ovarian axis.,2025,10.3389/fvets.2025.1668137,https://pubmed.ncbi.nlm.nih.gov/41112153/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C14orf39,ENSG00000179008,Unsafe,41109371,Single-cell RNA sequencing reveals oocyte-granulosa crosstalk and regulatory networks driving chicken primordial follicle assembly.,2025,10.1016/j.ijbiomac.2025.148357,https://pubmed.ncbi.nlm.nih.gov/41109371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C14orf39,ENSG00000179008,Unsafe,33508233,Homozygous mutations in C14orf39/SIX6OS1 cause non-obstructive azoospermia and premature ovarian insufficiency in humans.,2021,10.1016/j.ajhg.2021.01.010,https://pubmed.ncbi.nlm.nih.gov/33508233/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C14orf39,ENSG00000179008,Unsafe,35305148,In silico analysis of a novel pathogenic variant c.7G &gt; A in C14orf39 gene identified by WES in a Pakistani family with azoospermia.,2022,10.1007/s00438-022-01876-4,https://pubmed.ncbi.nlm.nih.gov/35305148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C14orf39,ENSG00000179008,Unsafe,34718620,Variations of C14ORF39 and SYCE1 Identified in Idiopathic Premature Ovarian Insufficiency and Nonobstructive Azoospermia.,2022,10.1210/clinem/dgab777,https://pubmed.ncbi.nlm.nih.gov/34718620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C14orf39,ENSG00000179008,Unsafe,35172124,Whole-exome sequencing improves the diagnosis and care of men with non-obstructive azoospermia.,2022,10.1016/j.ajhg.2022.01.011,https://pubmed.ncbi.nlm.nih.gov/35172124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C14orf39,ENSG00000179008,Unsafe,36689258,Identification of potential prognostic biomarkers in vulval squamous cell carcinoma based on human papillomavirus infection Status-Analysis of GSE183454.,2023,10.1080/01443615.2022.2160930,https://pubmed.ncbi.nlm.nih.gov/36689258/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C14orf39,ENSG00000179008,Unsafe,27796301,C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility.,2016,10.1038/ncomms13298,https://pubmed.ncbi.nlm.nih.gov/27796301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C14orf39,ENSG00000179008,Unsafe,33130294,Host genetics influences the relationship between the gut microbiome and psychiatric disorders.,2021,10.1016/j.pnpbp.2020.110153,https://pubmed.ncbi.nlm.nih.gov/33130294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C14orf39,ENSG00000179008,Unsafe,34794894,Genetics of ovarian insufficiency and defects of folliculogenesis.,2022,10.1016/j.beem.2021.101594,https://pubmed.ncbi.nlm.nih.gov/34794894/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C14orf39,ENSG00000179008,Unsafe,15703187,Natural antisense transcripts associated with genes involved in eye development.,2005,10.1093/hmg/ddi084,https://pubmed.ncbi.nlm.nih.gov/15703187/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf86,ENSG00000159761,Unsafe,35873494,Identifying Differential Expression Genes and Prognostic Signature Based on Subventricular Zone Involved Glioblastoma.,2022,10.3389/fgene.2022.912227,https://pubmed.ncbi.nlm.nih.gov/35873494/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf87,ENSG00000155330,Unsafe,42062449,The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration.,2026,10.1038/s41598-026-50740-7,https://pubmed.ncbi.nlm.nih.gov/42062449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf87,ENSG00000155330,Unsafe,42328790,Leukemia risk factor ARID5B coordinates HDAC-mediated transcriptional repression.,2026,10.1093/nar/gkag628,https://pubmed.ncbi.nlm.nih.gov/42328790/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,39118819,The rhythmic mind: brain functions of percussionists in improvisation.,2024,10.3389/fnhum.2024.1418727,https://pubmed.ncbi.nlm.nih.gov/39118819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,40058809,Molecular mechanisms leading to gamete fusion.,2025,10.5387/fms.24-00046,https://pubmed.ncbi.nlm.nih.gov/40058809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,37115356,In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters.,2023,10.1186/s13550-023-00988-1,https://pubmed.ncbi.nlm.nih.gov/37115356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,36737550,"Comparison of [18F]FIMP, [11C]MET, and [18F]FDG PET for early-phase assessment of radiotherapy response.",2023,10.1038/s41598-023-29166-y,https://pubmed.ncbi.nlm.nih.gov/36737550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,32295885,Spermatozoa lacking Fertilization Influencing Membrane Protein (FIMP) fail to fuse with oocytes in mice.,2020,10.1073/pnas.1917060117,https://pubmed.ncbi.nlm.nih.gov/32295885/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,35121373,First-in-human assessment of the novel LAT1 targeting PET probe 18F-FIMP.,2022,10.1016/j.bbrc.2022.01.099,https://pubmed.ncbi.nlm.nih.gov/35121373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,36050562,The vertebrate- and testis- specific transmembrane protein C11ORF94 plays a critical role in sperm-oocyte membrane binding.,2022,10.1186/s43556-022-00092-1,https://pubmed.ncbi.nlm.nih.gov/36050562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,38679328,Molecular basis for dual functions in pilus assembly modulated by the lid of a pilus-specific sortase.,2024,10.1016/j.jbc.2024.107329,https://pubmed.ncbi.nlm.nih.gov/38679328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,40140854,Treatment of sinusitis in children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-SIM-FIMMG).,2025,10.1186/s13052-025-01868-1,https://pubmed.ncbi.nlm.nih.gov/40140854/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,32393636,"Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice.",2020,10.1073/pnas.1922650117,https://pubmed.ncbi.nlm.nih.gov/32393636/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,31673030,18F-FIMP: a LAT1-specific PET probe for discrimination between tumor tissue and inflammation.,2019,10.1038/s41598-019-52270-x,https://pubmed.ncbi.nlm.nih.gov/31673030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,35057438,"Recommendations on Complementary Feeding as a Tool for Prevention of Non-Communicable Diseases (NCDs)-Paper Co-Drafted by the SIPPS, FIMP, SIDOHaD, and SINUPE Joint Working Group.",2022,10.3390/nu14020257,https://pubmed.ncbi.nlm.nih.gov/35057438/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,39501298,Treatment of acute pharyngitis in children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-FIMMG).,2024,10.1186/s13052-024-01789-5,https://pubmed.ncbi.nlm.nih.gov/39501298/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,37277856,Five-year fidelity assessment of an evidence-based parenting program (GenerationPMTO): inter-rater reliability following international implementation.,2023,10.1186/s12913-023-09611-4,https://pubmed.ncbi.nlm.nih.gov/37277856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,39427174,Treatment of mild to moderate community-acquired pneumonia in previously healthy children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-FIMMG-SIMG).,2024,10.1186/s13052-024-01786-8,https://pubmed.ncbi.nlm.nih.gov/39427174/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,37453426,The EGF-motif-containing protein SPE-36 is a secreted sperm protein required for fertilization in C. elegans.,2023,10.1016/j.cub.2023.06.051,https://pubmed.ncbi.nlm.nih.gov/37453426/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,33272286,Fall inducing movable platform (FIMP) for overground trips and slips.,2020,10.1186/s12984-020-00785-0,https://pubmed.ncbi.nlm.nih.gov/33272286/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,35096839,Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats.,2021,10.3389/fcell.2021.810118,https://pubmed.ncbi.nlm.nih.gov/35096839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,34591980,Neuroinflammation and immunoregulation in glioblastoma and brain metastases: Recent developments in imaging approaches.,2021,10.1111/cei.13668,https://pubmed.ncbi.nlm.nih.gov/34591980/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,36836469,"Use of Telemedicine Healthcare Systems in Children and Adolescents with Chronic Disease or in Transition Stages of Life: Consensus Document of the Italian Society of Telemedicine (SIT), of the Italian Society of Preventive and Social Pediatrics (SIPPS), of the Italian Society of Pediatric Primary Care (SICuPP), of the Italian Federation of Pediatric Doctors (FIMP) and of the Syndicate of Family Pediatrician Doctors (SIMPeF).",2023,10.3390/jpm13020235,https://pubmed.ncbi.nlm.nih.gov/36836469/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,41491758,Stability Amidst Change in the Measurement of Implementation Fidelity Over Time.,2025,10.1007/s11121-025-01864-1,https://pubmed.ncbi.nlm.nih.gov/41491758/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,39090673,Intersocietal survey on real-world asthma management in Italian children.,2024,10.1186/s13052-024-01718-6,https://pubmed.ncbi.nlm.nih.gov/39090673/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,36424643,A mixed methods protocol to implement universal firearm injury risk screening and intervention among youth and adults in emergency departments across a large US health system.,2022,10.1186/s43058-022-00371-6,https://pubmed.ncbi.nlm.nih.gov/36424643/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,35248142,"Manifesto of the pediatricians of Emilia-Romagna region, Italy, in favor of vaccination against COVID in children 5-11 years old.",2022,10.1186/s13052-022-01229-2,https://pubmed.ncbi.nlm.nih.gov/35248142/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,36836548,"Information and Training on the Use of Telemedicine in Pediatric Population: Consensus Document of the Italian Society of Telemedicine (SIT), of the Italian Society of Preventive and Social Pediatrics (SIPPS), of the Italian Society of Pediatric Primary Care (SICuPP), of the Italian Federation of Pediatric Doctors (FIMP), and of the Syndicate of Family Pediatrician Doctors (SIMPeF).",2023,10.3390/jpm13020314,https://pubmed.ncbi.nlm.nih.gov/36836548/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,36836432,"Use of Telemedicine Healthcare Systems in Pediatric Assistance at Territorial Level: Consensus Document of the Italian Society of Telemedicine (SIT), of the Italian Society of Preventive and Social Pediatrics (SIPPS), of the Italian Society of Pediatric Primary Care (SICuPP), of the Italian Federation of Pediatric Doctors (FIMP) and of the Syndicate of Family Pediatrician Doctors (SIMPeF).",2023,10.3390/jpm13020198,https://pubmed.ncbi.nlm.nih.gov/36836432/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,32802994,"Paediatric activities and adherence to vaccinations during the COVID-19 epidemic period in Tuscany, Italy: a survey of paediatricians.",2020,10.15167/2421-4248/jpmh2020.61.2.1626,https://pubmed.ncbi.nlm.nih.gov/32802994/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,30083617,Hexavalent vaccines: characteristics of available products and practical considerations from a panel of Italian experts.,2018,,https://pubmed.ncbi.nlm.nih.gov/30083617/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,29048980,"The 2016 Lifetime Immunization Schedule, approved by the Italian scientific societies: A new paradigm to promote vaccination at all ages.",2017,10.1080/21645515.2017.1366394,https://pubmed.ncbi.nlm.nih.gov/29048980/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,20591168,The FIMP Medicines for Children Research Network.,2010,10.1186/1824-7288-36-46,https://pubmed.ncbi.nlm.nih.gov/20591168/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,35602655,Clinical effects of durability of immunosuppression in virologically suppressed ART-initiating persons with HIV in Latin America. A retrospective cohort study.,2022,10.1016/j.lana.2021.100175,https://pubmed.ncbi.nlm.nih.gov/35602655/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf92,ENSG00000167194,Unsafe,21247483,Excellence in Family Paediatricians: the FIMP-MCRN (Medicines for Children Research Network) becomes a member of ENPR-EMA (European Network of Paediatric Research at the European Medicines Agency).,2011,10.1186/1824-7288-37-7,https://pubmed.ncbi.nlm.nih.gov/21247483/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf95,ENSG00000260456,Unsafe,42014397,"GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy.",2026,10.1038/s41467-026-71682-8,https://pubmed.ncbi.nlm.nih.gov/42014397/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf95,ENSG00000260456,Unsafe,42088459,Molecular Characterisations and the Association with Clinical Factors in &lt;i&gt;RET&lt;/i&gt; Fusion-Positive NSCLC: A Retrospective Study of the Single Center Cohort.,2026,10.2147/cmar.s579561,https://pubmed.ncbi.nlm.nih.gov/42088459/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf95,ENSG00000260456,Unsafe,39805841,Genome-wide association study unravels mechanisms of brain glymphatic activity.,2025,10.1038/s41467-024-55706-9,https://pubmed.ncbi.nlm.nih.gov/39805841/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf95,ENSG00000260456,Unsafe,40266017,Genetic Risk Factors in Normal Pressure Hydrocephalus: What We Know and What Is Next.,2025,10.1002/mds.30206,https://pubmed.ncbi.nlm.nih.gov/40266017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf95,ENSG00000260456,Unsafe,39141892,Risk Variants Associated With Normal Pressure Hydrocephalus: Genome-Wide Association Study in the FinnGen Cohort.,2024,10.1212/wnl.0000000000209694,https://pubmed.ncbi.nlm.nih.gov/39141892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf95,ENSG00000260456,Unsafe,36066633,Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers.,2022,10.1007/s00401-022-02454-z,https://pubmed.ncbi.nlm.nih.gov/36066633/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf95,ENSG00000260456,Unsafe,22407726,"Microcephaly, intellectual impairment, bilateral vesicoureteral reflux, distichiasis, and glomuvenous malformations associated with a 16q24.3 contiguous gene deletion and a Glomulin mutation.",2012,10.1002/ajmg.a.35229,https://pubmed.ncbi.nlm.nih.gov/22407726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C16orf95,ENSG00000260456,Unsafe,30658068,Identifying new associated pleiotropic SNPs with lipids by simultaneous test of multiple longitudinal traits: An Iranian family-based study.,2019,10.1016/j.gene.2019.01.007,https://pubmed.ncbi.nlm.nih.gov/30658068/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C17orf67,ENSG00000214226,Unsafe,33663605,Genome-wide epistasis analysis for Alzheimer's disease and implications for genetic risk prediction.,2021,10.1186/s13195-021-00794-8,https://pubmed.ncbi.nlm.nih.gov/33663605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C17orf67,ENSG00000214226,Unsafe,34533693,Preliminary study of genome-wide association identified novel susceptibility genes for thyroid-related hormones in Chinese population.,2022,10.1007/s13258-021-01165-1,https://pubmed.ncbi.nlm.nih.gov/34533693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C17orf67,ENSG00000214226,Unsafe,23361222,Molecular and clinical delineation of the 17q22 microdeletion phenotype.,2013,10.1038/ejhg.2012.306,https://pubmed.ncbi.nlm.nih.gov/23361222/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C17orf67,ENSG00000214226,Unsafe,23354108,Association between genetic determinants of peak height velocity during puberty and predisposition to adolescent idiopathic scoliosis.,2013,10.1097/brs.0b013e318287fcfd,https://pubmed.ncbi.nlm.nih.gov/23354108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C17orf67,ENSG00000214226,Unsafe,19266077,Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966.,2009,10.1371/journal.pgen.1000409,https://pubmed.ncbi.nlm.nih.gov/19266077/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C17orf75,ENSG00000108666,Unsafe,42495610,C17orf75 (Njmu-R1) promotes hepatocellular carcinoma progression: a pan-cancer analysis and experimental validation.,2026,10.3389/fimmu.2026.1828437,https://pubmed.ncbi.nlm.nih.gov/42495610/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C17orf75,ENSG00000108666,Unsafe,36084634,Mutations in SCNM1 cause orofaciodigital syndrome due to minor intron splicing defects affecting primary cilia.,2022,10.1016/j.ajhg.2022.08.009,https://pubmed.ncbi.nlm.nih.gov/36084634/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C17orf75,ENSG00000108666,Unsafe,36330220,Single-gene knockout-coupled omics analysis identifies C9orf85 and CXorf38 as two uncharacterized human proteins associated with ZIP8 malfunction.,2022,10.3389/fmolb.2022.991308,https://pubmed.ncbi.nlm.nih.gov/36330220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C17orf75,ENSG00000108666,Unsafe,34821436,A novel immunodiagnosis panel for hepatocellular carcinoma based on bioinformatics and the autoantibody-antigen system.,2022,10.1111/cas.15217,https://pubmed.ncbi.nlm.nih.gov/34821436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C17orf75,ENSG00000108666,Unsafe,22693380,Gene expression profiling of oral squamous cell carcinoma by differential display rt-PCR and identification of tumor biomarkers.,2010,10.1007/s13193-011-0054-x,https://pubmed.ncbi.nlm.nih.gov/22693380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C17orf75,ENSG00000108666,Unsafe,17604597,Identification of genes associated with tumorigenesis of retinoblastoma by microarray analysis.,2007,10.1016/j.ygeno.2007.05.002,https://pubmed.ncbi.nlm.nih.gov/17604597/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C18orf54,ENSG00000166845,Unsafe,37692934,C18ORF54 promotes immune infiltration and poor prognosis as a potential biomarker for hepatocellular carcinoma.,2023,,https://pubmed.ncbi.nlm.nih.gov/37692934/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C18orf54,ENSG00000166845,Unsafe,40705358,Novel Susceptibility Genes for Sepsis Revealed by a Cross-Tissue Transcriptome-Wide Association Study.,2026,10.1097/shk.0000000000002652,https://pubmed.ncbi.nlm.nih.gov/40705358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C18orf54,ENSG00000166845,Unsafe,39878408,Transcriptome-Wide Association Study Identified Novel Blood Tissue Gene Biomarkers for Prostate Cancer Risk.,2025,10.1002/pros.24859,https://pubmed.ncbi.nlm.nih.gov/39878408/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C19orf25,ENSG00000119559,Unsafe,41043659,The significance of urine extracellular vesicle DNA methylation detection in the diagnosis and classification of prostate cancer.,2026,10.1016/j.jare.2025.09.056,https://pubmed.ncbi.nlm.nih.gov/41043659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C19orf25,ENSG00000119559,Unsafe,39657680,Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening.,2024,10.1016/j.cels.2024.11.004,https://pubmed.ncbi.nlm.nih.gov/39657680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C19orf25,ENSG00000119559,Unsafe,40527220,Characterization of methylation profile in biofluid cell-free DNA and identification of differentially methylated genes for phenotypic representations in Parkinson's disease.,2025,10.1016/j.clineuro.2025.109014,https://pubmed.ncbi.nlm.nih.gov/40527220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C19orf84,ENSG00000262874,Unsafe,38359823,C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line.,2024,10.1016/j.molcel.2024.01.014,https://pubmed.ncbi.nlm.nih.gov/38359823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf105,ENSG00000180999,Unsafe,36295481,Screening and Bioinformatics Analysis of Crucial Gene of Heart Failure and Atrial Fibrillation Based on GEO Database.,2022,10.3390/medicina58101319,https://pubmed.ncbi.nlm.nih.gov/36295481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf105,ENSG00000180999,Unsafe,36222281,Identification of potential M2 macrophage-associated diagnostic biomarkers in coronary artery disease.,2022,10.1042/bsr20221394,https://pubmed.ncbi.nlm.nih.gov/36222281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf105,ENSG00000180999,Unsafe,34692796,Novel lncRNA-miRNA-mRNA Competing Endogenous RNA Triple Networks Associated Programmed Cell Death in Heart Failure.,2021,10.3389/fcvm.2021.747449,https://pubmed.ncbi.nlm.nih.gov/34692796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf105,ENSG00000180999,Unsafe,32682418,Identification of potential crucial genes in atrial fibrillation: a bioinformatic analysis.,2020,10.1186/s12920-020-00754-5,https://pubmed.ncbi.nlm.nih.gov/32682418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf105,ENSG00000180999,Unsafe,23246012,A gene-centric study of common carotid artery remodelling.,2013,10.1016/j.atherosclerosis.2012.11.002,https://pubmed.ncbi.nlm.nih.gov/23246012/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf141,ENSG00000203963,Unsafe,42608607,Immunometabolic regulation and tissue-resident immunity in autoimmune uveitis: from genetic susceptibility to the gut-spleen-eye axis.,2026,10.1007/s00011-026-02350-2,https://pubmed.ncbi.nlm.nih.gov/42608607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf141,ENSG00000203963,Unsafe,40075078,"GWAS identifies genetic loci, lifestyle factors and circulating biomarkers that are risk factors for sarcoidosis.",2025,10.1038/s41467-025-57829-z,https://pubmed.ncbi.nlm.nih.gov/40075078/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf141,ENSG00000203963,Unsafe,32437414,Variants in IL23R-C1orf141 and ADO-ZNF365-EGR2 are associated with susceptibility to Vogt-Koyanagi-Harada disease in Japanese population.,2020,10.1371/journal.pone.0233464,https://pubmed.ncbi.nlm.nih.gov/32437414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf141,ENSG00000203963,Unsafe,32826979,"Genetic control of CCL24, POR, and IL23R contributes to the pathogenesis of sarcoidosis.",2020,10.1038/s42003-020-01185-9,https://pubmed.ncbi.nlm.nih.gov/32826979/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf141,ENSG00000203963,Unsafe,28302172,Transcriptome analysis of bronchoalveolar lavage fluid from children with severe Mycoplasma pneumoniae pneumonia reveals novel gene expression and immunodeficiency.,2017,10.1186/s40246-017-0101-y,https://pubmed.ncbi.nlm.nih.gov/28302172/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf141,ENSG00000203963,Unsafe,26628628,Investigation of the association of Vogt-Koyanagi-Harada syndrome with IL23R-C1orf141 in Han Chinese Singaporean and ADO-ZNF365-EGR2 in Thai.,2016,10.1136/bjophthalmol-2015-307366,https://pubmed.ncbi.nlm.nih.gov/26628628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf141,ENSG00000203963,Unsafe,25854761,Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis.,2015,10.1038/ncomms7793,https://pubmed.ncbi.nlm.nih.gov/25854761/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf141,ENSG00000203963,Unsafe,25108386,Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3.,2014,10.1038/ng.3061,https://pubmed.ncbi.nlm.nih.gov/25108386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf167,ENSG00000215910,Unsafe,37076800,Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report.,2023,10.1186/s12883-023-03200-y,https://pubmed.ncbi.nlm.nih.gov/37076800/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf167,ENSG00000215910,Unsafe,34734498,Impact of natriuretic peptide polymorphisms on diastolic and metabolic function in a populational cohort: insights from the STANISLAS cohort.,2022,10.1002/ehf2.13674,https://pubmed.ncbi.nlm.nih.gov/34734498/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf167,ENSG00000215910,Unsafe,35713327,Focal facial dermal dysplasias type III: Two families with Setleis syndrome in China.,2022,10.1111/1346-8138.16488,https://pubmed.ncbi.nlm.nih.gov/35713327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf167,ENSG00000215910,Unsafe,31175347,Examination of the associations between m&lt;sup&gt;6&lt;/sup&gt;A-associated single-nucleotide polymorphisms and blood pressure.,2019,10.1038/s41440-019-0277-8,https://pubmed.ncbi.nlm.nih.gov/31175347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf226,ENSG00000239887,Unsafe,42310501,C1orf226 Promotes Glioma Stemness and Oncogenesis in Glioma via PLK1-Mediated Wnt/β-Catenin Signaling.,2026,10.1002/cam4.72048,https://pubmed.ncbi.nlm.nih.gov/42310501/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf226,ENSG00000239887,Unsafe,41309577,Recessive variants in the intergenic NOS1AP-C1orf226 locus cause monogenic kidney disease responsive to anti-proteinuric treatment.,2025,10.1038/s41467-025-65663-6,https://pubmed.ncbi.nlm.nih.gov/41309577/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf226,ENSG00000239887,Unsafe,33948357,An immune-related signature that to improve prognosis prediction of breast cancer.,2021,,https://pubmed.ncbi.nlm.nih.gov/33948357/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf56,ENSG00000143443,Unsafe,39963682,Identification of Five NK Cell-Related Hub Genes in COPD Using Single-Cell RNA Sequencing Analysis.,2025,10.2147/jir.s491298,https://pubmed.ncbi.nlm.nih.gov/39963682/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf56,ENSG00000143443,Unsafe,34354992,Identification of Sialyl-Lewis(x)-Interacting Protein on Human Spermatozoa.,2021,10.3389/fcell.2021.700396,https://pubmed.ncbi.nlm.nih.gov/34354992/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf56,ENSG00000143443,Unsafe,42107989,Large-Scale Plasma Proteomics Improves Prediction of Major Adverse Liver Outcomes in Individuals With MASLD.,2026,10.1111/dom.70824,https://pubmed.ncbi.nlm.nih.gov/42107989/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C1orf56,ENSG00000143443,Unsafe,22133874,Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis.,2012,10.1172/jci57292,https://pubmed.ncbi.nlm.nih.gov/22133874/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C22orf23,ENSG00000128346,Unsafe,33732283,The Novel Key Genes of Non-obstructive Azoospermia Affect Spermatogenesis: Transcriptomic Analysis Based on RNA-Seq and scRNA-Seq Data.,2021,10.3389/fgene.2021.608629,https://pubmed.ncbi.nlm.nih.gov/33732283/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C22orf23,ENSG00000128346,Unsafe,39233306,Influence of dexamethasone-induced matrices on the TM transcriptome.,2024,10.1016/j.exer.2024.110069,https://pubmed.ncbi.nlm.nih.gov/39233306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C22orf23,ENSG00000128346,Unsafe,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C22orf42,ENSG00000205856,Unsafe,36589848,Joint analysis of m6A and mRNA expression profiles in the testes of idiopathic nonobstructive azoospermia patients.,2022,10.3389/fendo.2022.1063929,https://pubmed.ncbi.nlm.nih.gov/36589848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C22orf42,ENSG00000205856,Unsafe,36246163,Stress Overload and DNA Methylation in African American Women in the Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure Study.,2022,10.1177/25168657221126314,https://pubmed.ncbi.nlm.nih.gov/36246163/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C22orf42,ENSG00000205856,Unsafe,31796052,Identification of key genes in invasive clinically non-functioning pituitary adenoma by integrating analysis of DNA methylation and mRNA expression profiles.,2019,10.1186/s12967-019-02148-3,https://pubmed.ncbi.nlm.nih.gov/31796052/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C22orf42,ENSG00000205856,Unsafe,32617195,Searching for a signature involving 10 genes to predict the survival of patients with acute myelocytic leukemia through a combined multi-omics analysis.,2020,10.7717/peerj.9437,https://pubmed.ncbi.nlm.nih.gov/32617195/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C22orf42,ENSG00000205856,Unsafe,26308446,Identification of Human N-Myristoylated Proteins from Human Complementary DNA Resources by Cell-Free and Cellular Metabolic Labeling Analyses.,2015,10.1371/journal.pone.0136360,https://pubmed.ncbi.nlm.nih.gov/26308446/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C2CD6,ENSG00000155754,Unsafe,34919125,C2CD6 regulates targeting and organization of the CatSper calcium channel complex in sperm flagella.,2022,10.1242/dev.199988,https://pubmed.ncbi.nlm.nih.gov/34919125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C2CD6,ENSG00000155754,Unsafe,38847481,Male infertility and perfluoroalkyl and poly-fluoroalkyl substances: evidence for alterations in phosphorylation of proteins and fertility-related functional attributes in bull spermatozoa†.,2024,10.1093/biolre/ioae089,https://pubmed.ncbi.nlm.nih.gov/38847481/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C2CD6,ENSG00000155754,Unsafe,34998468,C2cd6-encoded CatSperτ targets sperm calcium channel to Ca2+ signaling domains in the flagellar membrane.,2022,10.1016/j.celrep.2021.110226,https://pubmed.ncbi.nlm.nih.gov/34998468/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C2CD6,ENSG00000155754,Unsafe,31985809,Exome sequencing reveals novel causes as well as new candidate genes for human globozoospermia.,2020,10.1093/humrep/dez246,https://pubmed.ncbi.nlm.nih.gov/31985809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C2CD6,ENSG00000155754,Unsafe,36047070,Globozoospermia: A Case Report and Systematic Review of Literature.,2023,10.5534/wjmh.220020,https://pubmed.ncbi.nlm.nih.gov/36047070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C2CD6,ENSG00000155754,Unsafe,35002309,Development of Potential Prognostic Biomarkers Based on DNA Methylation-Driven Genes for Patients with Endometrial Cancer.,2021,10.2147/ijgm.s341771,https://pubmed.ncbi.nlm.nih.gov/35002309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C2CD6,ENSG00000155754,Unsafe,25168388,Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk.,2015,10.1093/hmg/ddu431,https://pubmed.ncbi.nlm.nih.gov/25168388/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C4orf46,ENSG00000205208,Unsafe,34076717,Inactivation of testis-specific gene C4orf46 is dispensable for spermatogenesis and fertility in mouse.,2021,10.1007/s00335-021-09879-z,https://pubmed.ncbi.nlm.nih.gov/34076717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C4orf46,ENSG00000205208,Unsafe,25059753,Expression and clinical significance of RCDG1 in renal cell carcinoma: a novel renal cancer‑associated gene.,2014,10.3892/mmr.2014.2388,https://pubmed.ncbi.nlm.nih.gov/25059753/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf24,ENSG00000181904,Unsafe,40038197,From Gene Discovery to Stroke Risk: C5orf24's Pivotal Role Uncovered.,2025,10.1007/s12035-025-04802-y,https://pubmed.ncbi.nlm.nih.gov/40038197/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf24,ENSG00000181904,Unsafe,40634861,CircRNA-miRNA-mRNA networks in plasma extracellular vesicles as biomarkers for first-onset schizophrenia.,2025,10.1186/s12888-025-07073-y,https://pubmed.ncbi.nlm.nih.gov/40634861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf24,ENSG00000181904,Unsafe,38537770,A novel enzyme-linked ligand-sorbent assay (ELLSA) to screening pulmonary tuberculosis: a retrospective cross-sectional study.,2024,10.1016/j.micinf.2024.105332,https://pubmed.ncbi.nlm.nih.gov/38537770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf24,ENSG00000181904,Unsafe,39747483,A feeding-induced myokine modulates glucose homeostasis.,2025,10.1038/s42255-024-01175-9,https://pubmed.ncbi.nlm.nih.gov/39747483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf24,ENSG00000181904,Unsafe,35858526,Associations between antenatal maternal asthma status and placental DNA methylation.,2022,10.1016/j.placenta.2022.06.008,https://pubmed.ncbi.nlm.nih.gov/35858526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf24,ENSG00000181904,Unsafe,31039430,Gene expression differences in PTSD are uniquely related to the intrusion symptom cluster: A transcriptome-wide analysis in military service members.,2019,10.1016/j.bbi.2019.04.039,https://pubmed.ncbi.nlm.nih.gov/31039430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf34,ENSG00000172244,Unsafe,41863161,From Biomarker to Drug Target: Integrating ceRNA Networks and Pharmacogenomics to Reposition C5orf34 in Uterine Corpus Endometrial Cancer Therapy.,2026,10.2174/0109298673434804260122043919,https://pubmed.ncbi.nlm.nih.gov/41863161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf34,ENSG00000172244,Unsafe,38078888,Integration of genomics and transcriptomics highlights the crucial role of chromosome 5 open reading frame 34 in various human malignancies.,2023,10.18632/aging.205310,https://pubmed.ncbi.nlm.nih.gov/38078888/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf34,ENSG00000172244,Unsafe,41422162,Integrative analysis of scRNA-seq and RNA-seq to investigate the prognostic value of lactylation and fibroblast-related genes in intrahepatic cholangiocarcinoma.,2025,10.1038/s41598-025-32764-7,https://pubmed.ncbi.nlm.nih.gov/41422162/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf34,ENSG00000172244,Unsafe,38951221,Comprehensive pan-cancer analysis reveals that C5orf34 regulates the proliferation and mortality of lung cancer.,2024,10.1007/s10142-024-01397-w,https://pubmed.ncbi.nlm.nih.gov/38951221/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf34,ENSG00000172244,Unsafe,30771479,Up-regulation of C5orf34 promotes lung adenocarcinoma migration and is correlated with worse prognosis.,2019,10.1016/j.gene.2019.02.019,https://pubmed.ncbi.nlm.nih.gov/30771479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf34,ENSG00000172244,Unsafe,34814312,Pathological analysis of hesperetin-derived small cell lung cancer by artificial intelligence technology under fiberoptic bronchoscopy.,2021,10.3934/mbe.2021423,https://pubmed.ncbi.nlm.nih.gov/34814312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf34,ENSG00000172244,Unsafe,27019060,Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies.,2018,10.1080/15592294.2016.1166321,https://pubmed.ncbi.nlm.nih.gov/27019060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf34,ENSG00000172244,Unsafe,31581300,A targeted genotyping approach to enhance the identification of variants for lactation persistency in dairy cows.,2019,10.1093/jas/skz279,https://pubmed.ncbi.nlm.nih.gov/31581300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf58,ENSG00000234511,Unsafe,39723414,Screening and regulatory mechanism exploration of M1 macrophage polarization and efferocytosis-related biomarkers in coronary heart disease.,2024,10.3389/fcvm.2024.1478827,https://pubmed.ncbi.nlm.nih.gov/39723414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf58,ENSG00000234511,Unsafe,34034705,Integrated analysis of methylation-driven genes and pretreatment prognostic factors in patients with hepatocellular carcinoma.,2021,10.1186/s12885-021-08314-5,https://pubmed.ncbi.nlm.nih.gov/34034705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf63,ENSG00000164241,Unsafe,33859829,Controlled human exposures to diesel exhaust: a human epigenome-wide experiment of target bronchial epithelial cells.,2021,10.1093/eep/dvab003,https://pubmed.ncbi.nlm.nih.gov/33859829/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf63,ENSG00000164241,Unsafe,27096627,Microarray Expression Data Identify DCC as a Candidate Gene for Early Meningioma Progression.,2016,10.1371/journal.pone.0153681,https://pubmed.ncbi.nlm.nih.gov/27096627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C5orf63,ENSG00000164241,Unsafe,33482370,A genome-wide association study for shoulder impingement and rotator cuff disease.,2021,10.1016/j.jse.2020.11.025,https://pubmed.ncbi.nlm.nih.gov/33482370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C6orf52,ENSG00000137434,Unsafe,40218432,Identification of Candidate Genes and eQTLs Related to Porcine Reproductive Function.,2025,10.3390/ani15071038,https://pubmed.ncbi.nlm.nih.gov/40218432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C6orf52,ENSG00000137434,Unsafe,35116980,"Effect of NOP2 knockdown on colon cancer cell proliferation, migration, and invasion.",2019,10.21037/tcr.2019.09.46,https://pubmed.ncbi.nlm.nih.gov/35116980/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C6orf52,ENSG00000137434,Unsafe,20127178,Annotation of novel transcripts putatively relevant for bovine fat metabolism.,2011,10.1007/s11033-010-9962-z,https://pubmed.ncbi.nlm.nih.gov/20127178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C7orf25,ENSG00000136197,Unsafe,42449115,Novel nuclear RNA export factor 1 adaptor drives tumor growth by increasing proliferation-stimulatory mRNA export.,2026,10.1038/s41392-026-02823-0,https://pubmed.ncbi.nlm.nih.gov/42449115/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C7orf25,ENSG00000136197,Unsafe,39682314,Genome-Wide Association Study and Phenotype Prediction of Reproductive Traits in Large White Pigs.,2024,10.3390/ani14233348,https://pubmed.ncbi.nlm.nih.gov/39682314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C7orf25,ENSG00000136197,Unsafe,34318869,Functionathon: a manual data mining workflow to generate functional hypotheses for uncharacterized human proteins and its application by undergraduate students.,2021,10.1093/database/baab046,https://pubmed.ncbi.nlm.nih.gov/34318869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C7orf25,ENSG00000136197,Unsafe,35180853,Integrated analysis of the prognostic and oncogenic roles of OPN3 in human cancers.,2022,10.1186/s12885-022-09219-7,https://pubmed.ncbi.nlm.nih.gov/35180853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C7orf25,ENSG00000136197,Unsafe,34462884,Identification of Four Enhancer-Associated Genes as Risk Signature for Diffuse Glioma Patients.,2022,10.1007/s12031-021-01861-3,https://pubmed.ncbi.nlm.nih.gov/34462884/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C7orf57,ENSG00000164746,Unsafe,35268118,Genome-Wide Association Study of Body Conformation Traits by Whole Genome Sequencing in Dazu Black Goats.,2022,10.3390/ani12050548,https://pubmed.ncbi.nlm.nih.gov/35268118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C7orf57,ENSG00000164746,Unsafe,26294325,Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy.,2015,10.1038/srep13390,https://pubmed.ncbi.nlm.nih.gov/26294325/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C7orf57,ENSG00000164746,Unsafe,19193627,A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.,2009,10.1093/hmg/ddp059,https://pubmed.ncbi.nlm.nih.gov/19193627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C9orf153,ENSG00000187753,Unsafe,37227814,Identification and validation of diagnostic signature genes in non-obstructive azoospermia by machine learning.,2023,10.18632/aging.204749,https://pubmed.ncbi.nlm.nih.gov/37227814/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
C9orf85,ENSG00000155621,Unsafe,36330220,Single-gene knockout-coupled omics analysis identifies C9orf85 and CXorf38 as two uncharacterized human proteins associated with ZIP8 malfunction.,2022,10.3389/fmolb.2022.991308,https://pubmed.ncbi.nlm.nih.gov/36330220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABLES2,ENSG00000149679,Unsafe,32779618,Characterization of a bicistronic knock-in reporter mouse model for investigating the role of CABLES2 in vivo.,2021,10.1538/expanim.20-0063,https://pubmed.ncbi.nlm.nih.gov/32779618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABLES2,ENSG00000149679,Unsafe,33949947,Disruption of entire &lt;i&gt;Cables2&lt;/i&gt; locus leads to embryonic lethality by diminished &lt;i&gt;Rps21&lt;/i&gt; gene expression and enhanced p53 pathway.,2021,10.7554/elife.50346,https://pubmed.ncbi.nlm.nih.gov/33949947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABLES2,ENSG00000149679,Unsafe,40506516,"Association between methylation quantitative trait loci and colorectal cancer risk, survival and cancer recurrence.",2025,10.1038/s41416-025-03064-8,https://pubmed.ncbi.nlm.nih.gov/40506516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABLES2,ENSG00000149679,Unsafe,33058866,"Identifying Novel Susceptibility Genes for Colorectal Cancer Risk From a Transcriptome-Wide Association Study of 125,478 Subjects.",2021,10.1053/j.gastro.2020.08.062,https://pubmed.ncbi.nlm.nih.gov/33058866/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABLES2,ENSG00000149679,Unsafe,33008348,Genetically-regulated transcriptomics & copy number variation of proctitis points to altered mitochondrial and DNA repair mechanisms in individuals of European ancestry.,2020,10.1186/s12885-020-07457-1,https://pubmed.ncbi.nlm.nih.gov/33008348/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABLES2,ENSG00000149679,Unsafe,28506205,In silico pathway analysis and tissue specific cis-eQTL for colorectal cancer GWAS risk variants.,2017,10.1186/s12864-017-3750-2,https://pubmed.ncbi.nlm.nih.gov/28506205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABLES2,ENSG00000149679,Unsafe,24174975,Identification of Target Genes Involved in the Antiproliferative Effect of Enzyme-Modified Ginseng Extract in HepG2 Hepatocarcinoma Cell.,2013,10.1155/2013/502568,https://pubmed.ncbi.nlm.nih.gov/24174975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABLES2,ENSG00000149679,Unsafe,19218781,Gene expression profiles in radiation workers occupationally exposed to ionizing radiation.,2009,10.1269/jrr.08034,https://pubmed.ncbi.nlm.nih.gov/19218781/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,42648358,Molecular basis for a Ca&lt;sup&gt;2+&lt;/sup&gt; binding hierarchy in the EF-hand motifs of CaBP2.,2026,10.1016/j.jbc.2026.113492,https://pubmed.ncbi.nlm.nih.gov/42648358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,40927552,Is &lt;i&gt;CABP2&lt;/i&gt;-Associated Hearing Loss (DFNB93) a Gene Therapy Target? Preclinical Progress and Patient Registry.,2025,10.1002/mco2.70363,https://pubmed.ncbi.nlm.nih.gov/40927552/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,39718549,CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells.,2024,10.7554/elife.93646,https://pubmed.ncbi.nlm.nih.gov/39718549/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,39260891,Comprehensive Characterization of a Subfamily of Ca&lt;sup&gt;2+&lt;/sup&gt;-Binding Proteins in Mouse and Human Retinal Neurons at Single-Cell Resolution.,2024,10.1523/eneuro.0145-24.2024,https://pubmed.ncbi.nlm.nih.gov/39260891/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,39936944,Structure-Function Diversity of Calcium-Binding Proteins (CaBPs): Key Roles in Cell Signalling and Disease.,2025,10.3390/cells14030152,https://pubmed.ncbi.nlm.nih.gov/39936944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,42231373,Molecular diagnosis of non-syndromic hearing loss in seven Iranian families using whole-exome sequencing.,2026,10.1186/s12920-026-02403-9,https://pubmed.ncbi.nlm.nih.gov/42231373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,38334748,Letting the calcium flow.,2024,10.7554/elife.96139,https://pubmed.ncbi.nlm.nih.gov/38334748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,39518841,Transcriptome and Metabolome Analyses Reveal High-Altitude Adaptation Mechanism of Epididymis Sperm Maturation in Tibetan Sheep.,2024,10.3390/ani14213117,https://pubmed.ncbi.nlm.nih.gov/39518841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,34489639,Cabp2-Gene Therapy Restores Inner Hair Cell Calcium Currents and Improves Hearing in a DFNB93 Mouse Model.,2021,10.3389/fnmol.2021.689415,https://pubmed.ncbi.nlm.nih.gov/34489639/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,35150090,Autosomal recessive nonsyndromic hearing impairment in two Finnish families due to the population enriched CABP2 c.637+1G>T variant.,2022,10.1002/mgg3.1866,https://pubmed.ncbi.nlm.nih.gov/35150090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,33666369,First reported CABP2-related non-syndromic hearing loss in Northern Europe.,2021,10.1002/mgg3.1639,https://pubmed.ncbi.nlm.nih.gov/33666369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,29661613,Functions of CaBP1 and CaBP2 in the peripheral auditory system.,2018,10.1016/j.heares.2018.04.001,https://pubmed.ncbi.nlm.nih.gov/29661613/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,28183797,Ca2+-binding protein 2 inhibits Ca2+-channel inactivation in mouse inner hair cells.,2017,10.1073/pnas.1617533114,https://pubmed.ncbi.nlm.nih.gov/28183797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,38192829,"Brachyolmia, dental anomalies and short stature (DASS): Phenotype and genotype analyses of Egyptian and Pakistani patients.",2024,10.1016/j.heliyon.2023.e23688,https://pubmed.ncbi.nlm.nih.gov/38192829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,27822497,Lack of CaBP1/Caldendrin or CaBP2 Leads to Altered Ganglion Cell Responses.,2016,10.1523/eneuro.0099-16.2016,https://pubmed.ncbi.nlm.nih.gov/27822497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,26809054,Expression and Localization of CaBP Ca2+ Binding Proteins in the Mouse Cochlea.,2016,10.1371/journal.pone.0147495,https://pubmed.ncbi.nlm.nih.gov/26809054/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,30263960,Molecular parallelism in fast-twitch muscle proteins in echolocating mammals.,2018,10.1126/sciadv.aat9660,https://pubmed.ncbi.nlm.nih.gov/30263960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,31195974,Epigenome-wide skeletal muscle DNA methylation profiles at the background of distinct metabolic types and ryanodine receptor variation in pigs.,2019,10.1186/s12864-019-5880-1,https://pubmed.ncbi.nlm.nih.gov/31195974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,22981119,"A mutation in CABP2, expressed in cochlear hair cells, causes autosomal-recessive hearing impairment.",2012,10.1016/j.ajhg.2012.08.018,https://pubmed.ncbi.nlm.nih.gov/22981119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,22366086,Trimethylation of histone H3K4 is associated with the induction of fructose-inducible genes in rat jejunum.,2012,10.1016/j.bbrc.2012.02.043,https://pubmed.ncbi.nlm.nih.gov/22366086/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABP2,ENSG00000167791,Unsafe,11108966,Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1).,2000,10.1016/s0167-4889(00)00099-9,https://pubmed.ncbi.nlm.nih.gov/11108966/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,38187237,"FTHL17, PRM2, CABYR, CPXCR1, ADAM29, and CABS1 are highly expressed in colon cancer patients and are regulated in vitro by epigenetic alterations.",2024,10.1016/j.heliyon.2023.e23689,https://pubmed.ncbi.nlm.nih.gov/38187237/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,33747357,The cancer testis antigens CABYR-a/b and CABYR-c are expressed in a subset of colorectal cancers and hold promise as targets for specific immunotherapy.,2021,10.18632/oncotarget.27897,https://pubmed.ncbi.nlm.nih.gov/33747357/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,38497118,A first complete catalog of highly expressed genes in eight chicken tissues reveals uncharacterized gene families specific for the chicken testis.,2024,10.1152/physiolgenomics.00151.2023,https://pubmed.ncbi.nlm.nih.gov/38497118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,37240164,Macrophage-Related Testicular Inflammation in Individuals with Idiopathic Non-Obstructive Azoospermia: A Single-Cell Analysis.,2023,10.3390/ijms24108819,https://pubmed.ncbi.nlm.nih.gov/37240164/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,30972801,Testis-specific calcium-binding protein CBP86-IV (CABYR) binds with phosphoglycerate kinase 2 in vitro and in vivo experiment.,2019,10.1111/and.13287,https://pubmed.ncbi.nlm.nih.gov/30972801/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,41386752,Advancing Understanding of the Protein Composition of Human Seminal Extracellular Vesicles.,2026,10.1002/pmic.70088,https://pubmed.ncbi.nlm.nih.gov/41386752/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,36228521,"Polygenic co-expression changes the testis growth, hormone secretion and spermatogenesis to prompt puberty in Hu sheep.",2022,10.1016/j.theriogenology.2022.09.025,https://pubmed.ncbi.nlm.nih.gov/36228521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,35804987,"Analysis of Exosomal Cargo Provides Accurate Clinical, Histologic and Mutational Information in Non-Small Cell Lung Cancer.",2022,10.3390/cancers14133216,https://pubmed.ncbi.nlm.nih.gov/35804987/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,25717016,Low-expressed testis-specific calcium-binding protein CBP86-IV (CABYR) is observed in idiopathic asthenozoospermia.,2015,10.1007/s00345-015-1516-5,https://pubmed.ncbi.nlm.nih.gov/25717016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,32973212,Novel targets identified by integrated proteomic and phosphoproteomic analysis in spermatogenesis of swamp buffalo (Bubalus bubalis).,2020,10.1038/s41598-020-72353-4,https://pubmed.ncbi.nlm.nih.gov/32973212/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,31692072,Upregulated calcium-binding tyrosine phosphorylation-regulated protein-a/b regulates cell proliferation and apoptosis and predicts poor prognosis in hepatocellular carcinoma.,2020,10.1002/jcb.29538,https://pubmed.ncbi.nlm.nih.gov/31692072/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,38694506,Predictive value of a stemness-based classifier for prognosis and immunotherapy response of hepatocellular carcinoma based on bioinformatics and machine-learning strategies.,2024,10.3389/fimmu.2024.1244392,https://pubmed.ncbi.nlm.nih.gov/38694506/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,24362251,Knockdown of CABYR-a/b increases chemosensitivity of human non-small cell lung cancer cells through inactivation of Akt.,2014,10.1158/1541-7786.mcr-13-0391,https://pubmed.ncbi.nlm.nih.gov/24362251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,36277216,Quantitative phosphoproteomics analyses reveal the regulatory mechanisms related to frozen-thawed sperm capacitation and acrosome reaction in yak (Bos grunniens).,2022,10.3389/fphys.2022.1013082,https://pubmed.ncbi.nlm.nih.gov/36277216/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,34336820,Comparative Proteomics and Phosphoproteomics Analysis Reveal the Possible Breed Difference in Yorkshire and Duroc Boar Spermatozoa.,2021,10.3389/fcell.2021.652809,https://pubmed.ncbi.nlm.nih.gov/34336820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,29247344,Molecular study of human sperm RNA: Ropporin and CABYR in asthenozoospermia.,2018,10.1007/s40618-017-0804-x,https://pubmed.ncbi.nlm.nih.gov/29247344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,26843620,Depletion of CABYR-a/b sensitizes lung cancer cells to TRAIL-induced apoptosis through YAP/p73-mediated DR5 upregulation.,2016,10.18632/oncotarget.7069,https://pubmed.ncbi.nlm.nih.gov/26843620/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,28121627,Identification of downstream metastasis-associated target genes regulated by LSD1 in colon cancer cells.,2017,10.18632/oncotarget.14778,https://pubmed.ncbi.nlm.nih.gov/28121627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,17317841,CABYR is a novel cancer-testis antigen in lung cancer.,2007,10.1158/1078-0432.ccr-06-1742,https://pubmed.ncbi.nlm.nih.gov/17317841/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,36054039,"Tomato spotted wilt orthotospovirus shifts sex ratio toward males in the western flower thrips, Frankliniella occidentalis, by down-regulating a FSCB-like gene.",2022,10.1002/ps.7125,https://pubmed.ncbi.nlm.nih.gov/36054039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,36580633,Effect of the Structure of Magnetic Nanocomposite Adsorbents on the Lysozyme Separation Efficiency.,2023,10.1021/acsabm.2c00833,https://pubmed.ncbi.nlm.nih.gov/36580633/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,21274509,Expression of the sperm fibrous sheath protein CABYR in human cancers and identification of α-enolase as an interacting partner of CABYR-a.,2011,10.3892/or.2011.1165,https://pubmed.ncbi.nlm.nih.gov/21274509/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,22021175,Loss of ASP but not ROPN1 reduces mammalian ciliary motility.,2012,10.1002/cm.20539,https://pubmed.ncbi.nlm.nih.gov/22021175/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,22006429,High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes.,2012,10.1002/cncr.26617,https://pubmed.ncbi.nlm.nih.gov/22006429/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,17727719,Effect of active smoking on the human bronchial epithelium transcriptome.,2007,10.1186/1471-2164-8-297,https://pubmed.ncbi.nlm.nih.gov/17727719/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,16139264,Translation and assembly of CABYR coding region B in fibrous sheath and restriction of calcium binding to coding region A.,2005,10.1016/j.ydbio.2005.07.005,https://pubmed.ncbi.nlm.nih.gov/16139264/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,15752768,Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain.,2005,10.1016/j.bbrc.2005.02.089,https://pubmed.ncbi.nlm.nih.gov/15752768/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CABYR,ENSG00000154040,Unsafe,11820818,"CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation.",2002,10.1006/dbio.2001.0527,https://pubmed.ncbi.nlm.nih.gov/11820818/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,42044188,Functional single nucleotide polymorphisms in CACNA2D3 and other autophagy-related genes are associated with leprosy among Brazilians.,2026,10.1371/journal.pntd.0014241,https://pubmed.ncbi.nlm.nih.gov/42044188/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,40680631,Epigenetic insights: unveiling the impact of hypomethylated CACNA2D3 and FLNA genes in breast cancer progression.,2025,10.1016/j.tranon.2025.102469,https://pubmed.ncbi.nlm.nih.gov/40680631/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,41908841,Antihypertensive Drug Target Genes and Epithelial Ovarian Cancer Risk: A Two-Sample Mendelian Randomization Study.,2026,10.2147/ijwh.s579065,https://pubmed.ncbi.nlm.nih.gov/41908841/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,41218711,miR-27a-3p targets CACNA2D3 to promote colorectal cancer progression via the Ca2+/ROS/mitochondrial apoptotic pathway.,2026,10.1016/j.bbadis.2025.168105,https://pubmed.ncbi.nlm.nih.gov/41218711/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,42545840,Increased Prevalence of Rare Copy Number Variants in Australian Children With Fetal Alcohol Spectrum Disorder: Experience in a State-Wide Diagnostic Service.,2026,10.1111/acer.70352,https://pubmed.ncbi.nlm.nih.gov/42545840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,39868909,GWAS Identifies CACNA2D3 Associated With Asthma and Atopic Dermatitis Multimorbidity in Children.,2025,10.1111/all.16483,https://pubmed.ncbi.nlm.nih.gov/39868909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,42158954,Integrative transcriptomic analysis revealed the roles and prognostic value of ion channels in hypertrophic cardiomyopathy.,2026,10.3389/fphar.2026.1810143,https://pubmed.ncbi.nlm.nih.gov/42158954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,41394903,Transcriptomic insights into the effects of tyrosine on sub-Columbian plumage in H line chickens.,2025,10.3389/fvets.2025.1720520,https://pubmed.ncbi.nlm.nih.gov/41394903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,40795403,Multiple autism genes influence GABA neuron remodeling via distinct developmental trajectories.,2025,10.1093/genetics/iyaf156,https://pubmed.ncbi.nlm.nih.gov/40795403/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,40388745,Using eQTL Mendelian randomization and transcriptomic analysis to identify the relationship between ion channel genes and intracranial aneurysmal subarachnoid hemorrhage.,2025,10.1097/md.0000000000042457,https://pubmed.ncbi.nlm.nih.gov/40388745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,42872142,Seasonal influences on DNA methylation at birth or at sampling time and their interaction with psychosis risk.,2026,10.1093/eep/dvag033,https://pubmed.ncbi.nlm.nih.gov/42872142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,42706869,MicroRNA-mRNA Networks in Skeletal Muscle of Tailored Pig Models for Dystrophinopathies.,2026,10.1002/jcsm.70337,https://pubmed.ncbi.nlm.nih.gov/42706869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,40173182,Human sensory-like neuron surfaceome analysis.,2025,10.1371/journal.pone.0320056,https://pubmed.ncbi.nlm.nih.gov/40173182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,40941431,Identification of Metabolic Pathways and Hub Genes Associated with Ultrasound Subcutaneous Fat and Muscle Depth of the Longissimus Muscle in Cull Beef Cows Using Gene Co-Expression Analysis.,2025,10.3390/ani15172636,https://pubmed.ncbi.nlm.nih.gov/40941431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,40301928,Identifying therapeutic target genes for diabetic retinopathy using systematic druggable genome-wide Mendelian randomization.,2025,10.1186/s13098-025-01710-y,https://pubmed.ncbi.nlm.nih.gov/40301928/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,39560568,Integrative analysis of single-nucleus RNA sequencing and Mendelian randomization to explore novel risk genes for Alzheimer's disease.,2024,10.1097/md.0000000000040551,https://pubmed.ncbi.nlm.nih.gov/39560568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,41144111,The effect of long-term adherence to physical activity recommendations in midlife on plasma proteins associated with frailty in the Atherosclerosis Risk in Communities (ARIC) study.,2026,10.1007/s10654-025-01282-1,https://pubmed.ncbi.nlm.nih.gov/41144111/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,39953207,"Validation of L-type calcium channel blocker amlodipine as a novel ADHD treatment through cross-species analysis, drug-target Mendelian randomization, and clinical evidence from medical records.",2025,10.1038/s41386-025-02062-x,https://pubmed.ncbi.nlm.nih.gov/39953207/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,40535026,Shared Genetic Characteristics of Coronary Artery Disease and Peripheral artery Disease: Insights From Integrated Bioinformatics Analysis of RNA-Sequencing Data.,2025,10.1177/11779322251344123,https://pubmed.ncbi.nlm.nih.gov/40535026/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,37929646,Ablation of the circadian rhythm protein CACNA2D3 impairs primordial follicle assembly in the mouse ovary.,2023,10.1002/ctm2.1467,https://pubmed.ncbi.nlm.nih.gov/37929646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,40885504,A transcriptomics-based analysis provides insights into the sex-dependent reproductive toxicity of DEHP in zebrafish (Danio rerio).,2025,10.1016/j.etap.2025.104810,https://pubmed.ncbi.nlm.nih.gov/40885504/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,39972314,Potential drug targets for ovarian cancer identified through Mendelian randomization and colocalization analysis.,2025,10.1186/s13048-025-01620-7,https://pubmed.ncbi.nlm.nih.gov/39972314/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,38338915,Nicotine Motivated Behavior in C. elegans.,2024,10.3390/ijms25031634,https://pubmed.ncbi.nlm.nih.gov/38338915/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,38767639,Clinical efficacy and gene chip expression analysis of Shenzhu Guanxin recipe granules in patients with intermediate coronary lesions.,2024,10.19852/j.cnki.jtcm.20240308.004,https://pubmed.ncbi.nlm.nih.gov/38767639/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,36624463,A two-stage genome-wide association study identifies novel germline genetic variations in CACNA2D3 associated with radiotherapy response in nasopharyngeal carcinoma.,2023,10.1186/s12967-022-03819-4,https://pubmed.ncbi.nlm.nih.gov/36624463/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,35045818,Revealing potential diagnostic gene biomarkers of septic shock based on machine learning analysis.,2022,10.1186/s12879-022-07056-4,https://pubmed.ncbi.nlm.nih.gov/35045818/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,33303529,Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use.,2021,10.1183/13993003.03388-2020,https://pubmed.ncbi.nlm.nih.gov/33303529/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,29692624,Comparative analysis of molecular signatures suggests the use of gabapentin for the management of endometriosis-associated pain.,2018,10.2147/jpr.s163611,https://pubmed.ncbi.nlm.nih.gov/29692624/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,27379157,"Do Copy Number Changes in CACNA2D2, CACNA2D3, and CACNA1D Constitute a Predisposing Risk Factor for Alzheimer's Disease?",2016,10.3389/fgene.2016.00107,https://pubmed.ncbi.nlm.nih.gov/27379157/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,34196487,Candidate l-methionine target piRNA regulatory networks analysis response to cocaine-conditioned place preference in mice.,2021,10.1002/brb3.2272,https://pubmed.ncbi.nlm.nih.gov/34196487/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,28892521,A systems medicine approach for finding target proteins affecting treatment outcomes in patients with non-Hodgkin lymphoma.,2017,10.1371/journal.pone.0183969,https://pubmed.ncbi.nlm.nih.gov/28892521/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,28431800,Genetic predictors of antipsychotic response to lurasidone identified in a genome wide association study and by schizophrenia risk genes.,2018,10.1016/j.schres.2017.04.009,https://pubmed.ncbi.nlm.nih.gov/28431800/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,27038408,GENOME-WIDE ASSOCIATION STUDY (GWAS) AND GENOME-WIDE BY ENVIRONMENT INTERACTION STUDY (GWEIS) OF DEPRESSIVE SYMPTOMS IN AFRICAN AMERICAN AND HISPANIC/LATINA WOMEN.,2016,10.1002/da.22484,https://pubmed.ncbi.nlm.nih.gov/27038408/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D3,ENSG00000157445,Unsafe,11687876,Tissue-specific expression and gabapentin-binding properties of calcium channel alpha2delta subunit subtypes.,2001,10.1007/s00232-001-0072-7,https://pubmed.ncbi.nlm.nih.gov/11687876/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,40883544,Intrafamilial variability of phenotype in CACNA2D4-associated retinal dysfunction: more or less.,2025,10.1007/s10633-025-10047-w,https://pubmed.ncbi.nlm.nih.gov/40883544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,42706869,MicroRNA-mRNA Networks in Skeletal Muscle of Tailored Pig Models for Dystrophinopathies.,2026,10.1002/jcsm.70337,https://pubmed.ncbi.nlm.nih.gov/42706869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,42105630,DNA methylation signatures associated with bipolar disorder in peripheral blood improve prediction models.,2026,10.1016/j.ebiom.2026.106284,https://pubmed.ncbi.nlm.nih.gov/42105630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,33927996,Novel compound heterozygous missense variants (c.G955A and c.A1822C) of CACNA2D4 likely causing autosomal recessive retinitis pigmentosa in a Chinese patient.,2021,10.1007/s13205-021-02761-4,https://pubmed.ncbi.nlm.nih.gov/33927996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,37672513,Identification of candidate genes for developmental colour agnosia in a single unique family.,2023,10.1371/journal.pone.0290013,https://pubmed.ncbi.nlm.nih.gov/37672513/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,36361866,Depleted Calcium Stores and Increased Calcium Entry in Rod Photoreceptors of the Cacna2d4 Mouse Model of Cone-Rod Dystrophy RCD4.,2022,10.3390/ijms232113080,https://pubmed.ncbi.nlm.nih.gov/36361866/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,36178085,Comprehensive methylome sequencing reveals prognostic epigenetic biomarkers for prostate cancer mortality.,2022,10.1002/ctm2.1030,https://pubmed.ncbi.nlm.nih.gov/36178085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,37789414,Identification of methylation-regulated genes modulating microglial phagocytosis in hyperhomocysteinemia-exacerbated Alzheimer's disease.,2023,10.1186/s13195-023-01311-9,https://pubmed.ncbi.nlm.nih.gov/37789414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,35353835,The voltage-gated Ca2+ channel subunit α2δ-4 regulates locomotor behavior and sensorimotor gating in mice.,2022,10.1371/journal.pone.0263197,https://pubmed.ncbi.nlm.nih.gov/35353835/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,36046118,Alterations in the Ca2+ toolkit in oesophageal adenocarcinoma.,2021,10.37349/etat.2021.00063,https://pubmed.ncbi.nlm.nih.gov/36046118/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,37194451,Integration of GWAS and eGWAS to screen candidate genes underlying green head traits in male ducks.,2023,10.1111/age.13329,https://pubmed.ncbi.nlm.nih.gov/37194451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,33316381,Development and clinical validation of a novel 9-gene prognostic model based on multi-omics in pancreatic adenocarcinoma.,2021,10.1016/j.phrs.2020.105370,https://pubmed.ncbi.nlm.nih.gov/33316381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,31834350,A New Zebrafish Model for CACNA2D4-Dysfunction.,2019,10.1167/iovs.19-26759,https://pubmed.ncbi.nlm.nih.gov/31834350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,32122382,Comprehensive analysis of differential immunocyte infiltration and the potential ceRNA networks during epicardial adipose tissue development in congenital heart disease.,2020,10.1186/s12967-020-02279-y,https://pubmed.ncbi.nlm.nih.gov/32122382/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,33168897,Transcriptome and methylome analysis reveals three cellular origins of pituitary tumors.,2020,10.1038/s41598-020-76555-8,https://pubmed.ncbi.nlm.nih.gov/33168897/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,34996991,Functional assays of non-canonical splice-site variants in inherited retinal dystrophies genes.,2022,10.1038/s41598-021-03925-1,https://pubmed.ncbi.nlm.nih.gov/34996991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,32224525,Molecular alterations in non-functioning pituitary adenomas.,2020,10.3233/cbm-191121,https://pubmed.ncbi.nlm.nih.gov/32224525/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,32571372,Genetic associations between voltage-gated calcium channels and autism spectrum disorder: a systematic review.,2020,10.1186/s13041-020-00634-0,https://pubmed.ncbi.nlm.nih.gov/32571372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,35721735,"Genome-Wide Placental Gene Methylations in Gestational Diabetes Mellitus, Fetal Growth and Metabolic Health Biomarkers in Cord Blood.",2022,10.3389/fendo.2022.875180,https://pubmed.ncbi.nlm.nih.gov/35721735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,29875267,α2δ-4 Is Required for the Molecular and Structural Organization of Rod and Cone Photoreceptor Synapses.,2018,10.1523/jneurosci.3818-16.2018,https://pubmed.ncbi.nlm.nih.gov/29875267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,31510946,Metastatic colorectal cancer and severe hypocalcemia following irinotecan administration in a patient with X-linked agammaglobulinemia: a case report.,2019,10.1186/s12881-019-0880-1,https://pubmed.ncbi.nlm.nih.gov/31510946/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CACNA2D4,ENSG00000151062,Unsafe,12181424,Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.,2002,10.1124/mol.62.3.485,https://pubmed.ncbi.nlm.nih.gov/12181424/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALHM4,ENSG00000164451,Unsafe,38896440,Structural features of heteromeric channels composed of CALHM2 and CALHM4 paralogs.,2024,10.7554/elife.96138,https://pubmed.ncbi.nlm.nih.gov/38896440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALHM4,ENSG00000164451,Unsafe,32374262,Cryo-EM structures and functional properties of CALHM channels of the human placenta.,2020,10.7554/elife.55853,https://pubmed.ncbi.nlm.nih.gov/32374262/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,42399934,Convergence of schizophrenia risk genes on CALN1 disrupts human forebrain development and drives core psychotic behaviors including hallucination-like perception.,2026,10.1186/s12916-026-05039-9,https://pubmed.ncbi.nlm.nih.gov/42399934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,42305510,Identification and validation of tumor microenvironment remodeling markers associated with prognosis in differentiated thyroid cancer.,2026,10.21037/tcr-2026-1-0208,https://pubmed.ncbi.nlm.nih.gov/42305510/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,41554730,Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder.,2026,10.1038/s41467-026-68351-1,https://pubmed.ncbi.nlm.nih.gov/41554730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,42193434,Ligand-Receptor Interaction Combined with Histopathology Improves Glioma Prognostic Model.,2026,10.3390/biomedicines14051110,https://pubmed.ncbi.nlm.nih.gov/42193434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,39936944,Structure-Function Diversity of Calcium-Binding Proteins (CaBPs): Key Roles in Cell Signalling and Disease.,2025,10.3390/cells14030152,https://pubmed.ncbi.nlm.nih.gov/39936944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,40447192,Post-transcriptional regulation of H19 by m&lt;sup&gt;6&lt;/sup&gt;A reader proteins: H19 stability versus miR-675 biogenesis.,2025,10.1016/j.jbc.2025.110303,https://pubmed.ncbi.nlm.nih.gov/40447192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,42652009,Multi-Breed Genome-Wide Association Analysis Reveals Candidate Genes for Growth and Body Conformation Traits in Four Populations of Native and Crossbred Chinese Sheep.,2026,10.3390/ani16162605,https://pubmed.ncbi.nlm.nih.gov/42652009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,39768205,Apolipoprotein-L Functions in Membrane Remodeling.,2024,10.3390/cells13242115,https://pubmed.ncbi.nlm.nih.gov/39768205/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,41012410,Examination of DNA Methylation Patterns in Children Born Premature with Prenatal Tobacco Smoke Exposure.,2025,10.3390/toxics13090789,https://pubmed.ncbi.nlm.nih.gov/41012410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,41912496,Genetic study identifies novel genes in developmental dysplasia of the hip.,2026,10.1038/s41413-026-00514-8,https://pubmed.ncbi.nlm.nih.gov/41912496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,38478101,The Janus-faced functions of Apolipoproteins L in membrane dynamics.,2024,10.1007/s00018-024-05180-9,https://pubmed.ncbi.nlm.nih.gov/38478101/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,39518841,Transcriptome and Metabolome Analyses Reveal High-Altitude Adaptation Mechanism of Epididymis Sperm Maturation in Tibetan Sheep.,2024,10.3390/ani14213117,https://pubmed.ncbi.nlm.nih.gov/39518841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,36401602,Identification of core genes in prefrontal cortex and hippocampus of Alzheimer's disease based on mRNA-miRNA network.,2022,10.1111/jcmm.17593,https://pubmed.ncbi.nlm.nih.gov/36401602/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,36946344,[Bioinformatic analysis of the clinical significance of calneuron 1 (CALN1) in glioma and its correlation with immune cell infiltration].,2023,,https://pubmed.ncbi.nlm.nih.gov/36946344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,36352401,CALN1 hypomethylation as a biomarker for high-risk bladder cancer.,2022,10.1186/s12894-022-01136-y,https://pubmed.ncbi.nlm.nih.gov/36352401/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,39501152,"Identifying low-density, ancestry-informative SNP markers through whole genome resequencing in Indian, Chinese, and wild yak.",2024,10.1186/s12864-024-10924-9,https://pubmed.ncbi.nlm.nih.gov/39501152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,33328525,Genes associated with cognitive performance in the Morris water maze: an RNA-seq study.,2020,10.1038/s41598-020-78997-6,https://pubmed.ncbi.nlm.nih.gov/33328525/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,37000665,[Changes in Expression of Genes Associated with Calcium Processes in the Hippocampus in Mice Exposed to Chronic Social Stress].,2023,10.31857/s0026898423020192,https://pubmed.ncbi.nlm.nih.gov/37000665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,29109191,Calneuron 1 Increased Ca2+ in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma.,2018,10.1161/hypertensionaha.117.10205,https://pubmed.ncbi.nlm.nih.gov/29109191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,35180297,Genetic pleiotropy between pulmonary function and age-related traits: The Long Life Family Study.,2022,10.1093/gerona/glac046,https://pubmed.ncbi.nlm.nih.gov/35180297/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,35445848,Global expression profiling of CD10 + /CD19 + pre-B lymphoblasts from Hispanic B-ALL patients correlates with comparative TARGET database analysis.,2022,10.1007/s12672-022-00480-7,https://pubmed.ncbi.nlm.nih.gov/35445848/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,28577753,Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2.,2017,10.1016/j.biopsych.2017.04.013,https://pubmed.ncbi.nlm.nih.gov/28577753/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,32874133,Identification of potential biomarkers and candidate small molecule drugs in glioblastoma.,2020,10.1186/s12935-020-01515-1,https://pubmed.ncbi.nlm.nih.gov/32874133/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CALN1,ENSG00000183166,Unsafe,11286509,"Identification of a human brain-specific gene, calneuron 1, a new member of the calmodulin superfamily.",2001,10.1006/mgme.2001.3160,https://pubmed.ncbi.nlm.nih.gov/11286509/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,41655987,CaMKIV negatively regulates osteoblast differentiation by modulating c-Fos and NFATc1 signaling: an in vitro and in vivo mechanistic study.,2026,,https://pubmed.ncbi.nlm.nih.gov/41655987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,41888906,Macrophage-associated kinase signaling in atherosclerosis - a systematic review.,2026,10.1186/s12964-026-02829-9,https://pubmed.ncbi.nlm.nih.gov/41888906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,42801669,Hederagenin Attenuates Morphine Addiction via GABAA1-Mediated Modulation of Ca&lt;sup&gt;2&lt;/sup&gt; &lt;sup&gt;+&lt;/sup&gt;-CaMK-CREB Signaling in Ventral Tegmental Dopaminergic Neurons.,2026,10.1002/advs.77820,https://pubmed.ncbi.nlm.nih.gov/42801669/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,42724460,Decreased H3K79 acetylation and dysregulation of neurodevelopmental genes in fetal down syndrome.,2026,10.21037/tp-2026-0272,https://pubmed.ncbi.nlm.nih.gov/42724460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,42467600,Verapamil Reduces Collagen Synthesis to Alleviate Ureteral Scar Formation by Inhibiting KDM1A-Mediated Epigenetic Silencing of SESN2.,2026,10.1159/000553434,https://pubmed.ncbi.nlm.nih.gov/42467600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,41227414,Integrative Transcriptomic and Proteomic Analysis Reveals &lt;i&gt;CaMK4&lt;/i&gt;-Mediated Regulation of Proliferation in Goat Skeletal Muscle Satellite Cells.,2025,10.3390/ani15213083,https://pubmed.ncbi.nlm.nih.gov/41227414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,40359038,CaMK modulates sensory neural activity to control longevity and proteostasis.,2025,10.1073/pnas.2423428122,https://pubmed.ncbi.nlm.nih.gov/40359038/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,41977373,Cell-Targeted Inhibition of CaMK4 Suppresses Tertiary Lymphoid-like Structure Development in Lupus-Prone Mice.,2026,10.3390/ijms27073190,https://pubmed.ncbi.nlm.nih.gov/41977373/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,42448704,Osteocyte parvalbumin mediates mechanotransduction to attenuate osteoarthritis.,2026,10.1038/s41467-026-75578-5,https://pubmed.ncbi.nlm.nih.gov/42448704/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,40529249,Sleep is enhanced in aged male mice that overexpress calcium/calmodulin-dependent protein kinase IV.,2025,10.3389/fnins.2025.1596602,https://pubmed.ncbi.nlm.nih.gov/40529249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,38892382,CaMKIV-Mediated Phosphorylation Inactivates Freud-1/CC2D1A Repression for Calcium-Dependent 5-HT1A Receptor Gene Induction.,2024,10.3390/ijms25116194,https://pubmed.ncbi.nlm.nih.gov/38892382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,40336480,Impaired CAMK4 Activity Limits Atherosclerosis and Reprograms Myelopoiesis.,2025,10.1161/atvbaha.125.322530,https://pubmed.ncbi.nlm.nih.gov/40336480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,41868184,Advances and Therapeutic Potential of Anthraquinone Compounds in Neurodegenerative Diseases: A Comprehensive Review.,2026,10.2147/dddt.s580330,https://pubmed.ncbi.nlm.nih.gov/41868184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,40994415,Congenital Hypothyroidism Dysregulates TRPC6 to Mediate Abnormal Dendritic Spine Growth of Hippocampal Neurons.,2025,10.1111/cns.70618,https://pubmed.ncbi.nlm.nih.gov/40994415/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,40999918,Calhm6 Governs Macrophage Polarization Through Chp1-Camk4-Creb1 Axis and Ectosomal Delivery in Inflammatory Responses.,2026,10.1002/advs.202502395,https://pubmed.ncbi.nlm.nih.gov/40999918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,42886654,Proteomic Landscape and Clinical Implications of Ovarian Carcinosarcoma.,2026,10.1096/fj.202503966r,https://pubmed.ncbi.nlm.nih.gov/42886654/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,40861924,The ROS/CaMK II/β-Catenin Signaling Axis Affects the Osteogenic Potential of BMSCs and Disrupts Implant Osseointegration: An In Vitro Study.,2025,10.1155/ijod/5566776,https://pubmed.ncbi.nlm.nih.gov/40861924/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,41467319,Hypoxia Exacerbates Periapical Periodontitis-Associated Pathological Bone Loss via the Hypoxia-Inducible Factor-2α-Calmodulin-Dependent Protein Kinase IV Axis.,2026,10.1111/cpr.70160,https://pubmed.ncbi.nlm.nih.gov/41467319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,42794727,CREB1 and GSK3 Isoforms as Potential Adaptive Signaling Nodes in PI3K/Akt/mTOR Inhibitor Treated Philadelphia Chromosome-Positive B-ALL.,2026,10.3390/ijms27188300,https://pubmed.ncbi.nlm.nih.gov/42794727/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,42575223,Calmodulin trimethylation by calmodulin-lysine N-methyltransferase plays an anti-inflammatory role by inhibiting caspase-11 noncanonical inflammasome in macrophages.,2026,10.1016/j.micpath.2026.108758,https://pubmed.ncbi.nlm.nih.gov/42575223/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,41120125,SPP1&lt;sup&gt;high&lt;/sup&gt; macrophage-induced T-cell stress promotes colon cancer liver metastasis through SPP1/CD44/PI3K/AKT signaling.,2025,10.1136/jitc-2025-012330,https://pubmed.ncbi.nlm.nih.gov/41120125/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,41828509,Molecular Mechanisms and Targeted Intervention Strategies of Calcium Overload in Ischemic Stroke.,2026,10.3390/ijms27052279,https://pubmed.ncbi.nlm.nih.gov/41828509/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,42014786,Transcranial vibrotactile stimulation enhances hippocampal cholinergic signaling and memory through frequency-dependent mechanotransduction.,2026,10.1038/s41598-026-49377-3,https://pubmed.ncbi.nlm.nih.gov/42014786/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,42045130,Effects of increasing intranuclear calcium levels via MCU inhibition on mouse and human PSC-derived cardiomyocyte differentiation and maturation.,2026,10.1093/stcltm/szag021,https://pubmed.ncbi.nlm.nih.gov/42045130/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,42204133,LISS enables immune evasion of colorectal cancers irrespective of MSI status.,2026,10.1038/s41392-026-02671-y,https://pubmed.ncbi.nlm.nih.gov/42204133/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,41361820,Dihydroartemisinin alleviates pulmonary fibrosis by modulating the calcium signaling pathway in fibroblasts.,2025,10.1186/s12967-025-07525-9,https://pubmed.ncbi.nlm.nih.gov/41361820/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,42794805,GLP-1 Receptor Agonists as Molecular Relievers of Lipotoxic Stress: From Pancreatic Beta-Cell Cholesterol Efflux to Systemic and Tissue-Specific Metabolic Protection.,2026,10.3390/ijms27188378,https://pubmed.ncbi.nlm.nih.gov/42794805/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,38287012,CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses.,2024,10.1038/s41467-024-45080-x,https://pubmed.ncbi.nlm.nih.gov/38287012/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,39132626,"CaMK II in Cardiovascular Diseases, Especially CaMK II-δ: Friends or Enemies.",2024,10.2147/dddt.s473251,https://pubmed.ncbi.nlm.nih.gov/39132626/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,42739051,"ABCA1 as a Gatekeeper of Pancreatic β-Cell Cholesterol Homeostasis: Links Between Lipoprotein Stress, Lipotoxicity, and Insulin Secretion.",2026,10.3390/nu18172879,https://pubmed.ncbi.nlm.nih.gov/42739051/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,39793862,Calcium calmodulin kinase IV deficiency in podocytes prevents the development of lupus nephritis.,2025,10.1016/j.clim.2025.110427,https://pubmed.ncbi.nlm.nih.gov/39793862/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,42575427,taVNS alleviates preeclampsia-induced placental trophoblast dysfunction by attenuating endoplasmic reticulum Ca&lt;sup&gt;2+&lt;/sup&gt; dysregulation via ACh-M3AChR-PERK/IP3R1 signaling.,2026,10.1016/j.mce.2026.112893,https://pubmed.ncbi.nlm.nih.gov/42575427/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,38615920,"CaMK4: Structure, physiological functions, and therapeutic potential.",2024,10.1016/j.bcp.2024.116204,https://pubmed.ncbi.nlm.nih.gov/38615920/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,12065094,Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer.,2002,10.1016/s0304-3835(02)00107-6,https://pubmed.ncbi.nlm.nih.gov/12065094/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,7961813,Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV. Identification of a brain CaM-kinase IV kinase.,1994,10.1016/s0021-9258(19)61953-8,https://pubmed.ncbi.nlm.nih.gov/7961813/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAMK4,ENSG00000152495,Unsafe,8397199,"Expression of a Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, in human T lymphocytes. Regulation of kinase activity by T cell receptor signaling.",1993,10.1016/s0021-9258(20)80693-0,https://pubmed.ncbi.nlm.nih.gov/8397199/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,41683570,Potential Link Between a Disruptive &lt;i&gt;CAPN6&lt;/i&gt; Variant and Neurodevelopmental Disorders.,2026,10.3390/ijms27031140,https://pubmed.ncbi.nlm.nih.gov/41683570/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,42512880,Differential Gene Expression in Synovium Between Male and Female Knee Osteoarthritis.,2026,10.3390/medicina62071338,https://pubmed.ncbi.nlm.nih.gov/42512880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,41372112,Sympathetic nerve inhibition enhances calvarial bone repair via senescent macrophage-induced osteogenesis and angiogenesis.,2025,10.1038/s41420-025-02886-y,https://pubmed.ncbi.nlm.nih.gov/41372112/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,38939621,Gene expression profiling and the isocitrate dehydrogenase mutational landscape of temozolomide‑resistant glioblastoma.,2024,10.3892/ol.2024.14511,https://pubmed.ncbi.nlm.nih.gov/38939621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,37243758,Advanced glycation end products promote the progression of chronic kidney diseases by targeting calpain 6.,2023,10.1007/s00726-023-03282-5,https://pubmed.ncbi.nlm.nih.gov/37243758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,33000175,CAPN6 in disease: An emerging therapeutic target (Review).,2020,10.3892/ijmm.2020.4734,https://pubmed.ncbi.nlm.nih.gov/33000175/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,34435644,Calpain 6 inhibits autophagy in inflammatory environments: A preliminary study on myoblasts and a chronic kidney disease rat model.,2021,10.3892/ijmm.2021.5027,https://pubmed.ncbi.nlm.nih.gov/34435644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,37296697,Identification of Basement Membrane-Related Signatures in Gastric Cancer.,2023,10.3390/diagnostics13111844,https://pubmed.ncbi.nlm.nih.gov/37296697/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,36930113,The specific phagocytosis regulators could predict recurrence and therapeutic effect in thyroid cancer: A study based on bioinformatics analysis.,2023,10.1097/md.0000000000033290,https://pubmed.ncbi.nlm.nih.gov/36930113/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,37108057,HuR Promotes the Differentiation of Goat Skeletal Muscle Satellite Cells by Regulating Myomaker mRNA Stability.,2023,10.3390/ijms24086893,https://pubmed.ncbi.nlm.nih.gov/37108057/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,38929389,Temporal Transcriptome Dynamics of Longissimus dorsi Reveals the Mechanism of the Differences in Muscle Development and IMF Deposition between Fuqing Goats and Nubian Goats.,2024,10.3390/ani14121770,https://pubmed.ncbi.nlm.nih.gov/38929389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,32161009,CAPN6 Regulates Uterine Leiomyoma Cell Proliferation and Apoptosis through the Rac1-Dependent Signaling Pathway.,2020,,https://pubmed.ncbi.nlm.nih.gov/32161009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,37287534,ATAC-seq reveals the roles of chromatin accessibility in the chondrocytes of Kashin-Beck disease compared with primary osteoarthritis.,2023,10.3389/fgene.2023.1169417,https://pubmed.ncbi.nlm.nih.gov/37287534/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,36703136,"H3K4me3 mediates uterine leiomyoma pathogenesis via neuronal processes, synapsis components, proliferation, and Wnt/β-catenin and TGF-β pathways.",2023,10.1186/s12958-023-01060-2,https://pubmed.ncbi.nlm.nih.gov/36703136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,31403686,MicroRNA Alteration in Developing Rat Oligodendrocyte Precursor Cells Induced by Hypoxia-Ischemia.,2019,10.1093/jnen/nlz071,https://pubmed.ncbi.nlm.nih.gov/31403686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,26375440,miR-449a promotes liver cancer cell apoptosis by downregulation of Calpain 6 and POU2F1.,2016,10.18632/oncotarget.4821,https://pubmed.ncbi.nlm.nih.gov/26375440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,27525442,Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.,2016,10.1172/jci85880,https://pubmed.ncbi.nlm.nih.gov/27525442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,33612391,Gene expression patterns associated with tumor-infiltrating CD4+ and CD8+ T cells in invasive breast carcinomas.,2021,10.1016/j.humimm.2021.02.001,https://pubmed.ncbi.nlm.nih.gov/33612391/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,23935533,Calpain-6 deficiency promotes skeletal muscle development and regeneration.,2013,10.1371/journal.pgen.1003668,https://pubmed.ncbi.nlm.nih.gov/23935533/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,33176622,Transcriptomics and Prognosis Analysis to Identify Critical Biomarkers in Invasive Breast Carcinoma.,2020,10.1177/1533033820957011,https://pubmed.ncbi.nlm.nih.gov/33176622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,23497022,Gene and protein patterns of potential prion-related markers in the central nervous system of clinical and preclinical infected sheep.,2013,10.1186/1297-9716-44-14,https://pubmed.ncbi.nlm.nih.gov/23497022/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPN6,ENSG00000077274,Unsafe,24086288,Transcription profiles of endothelial cells in the rat ductus arteriosus during a perinatal period.,2013,10.1371/journal.pone.0073685,https://pubmed.ncbi.nlm.nih.gov/24086288/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPSL,ENSG00000152611,Unsafe,39264149,Dysfunction of Calcyphosine-Like gene impairs retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy.,2024,10.7554/elife.96907,https://pubmed.ncbi.nlm.nih.gov/39264149/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPSL,ENSG00000152611,Unsafe,38612837,"Prevalence of Selected Polymorphisms of Il7R, CD226, CAPSL, and CLEC16A Genes in Children and Adolescents with Autoimmune Thyroid Diseases.",2024,10.3390/ijms25074028,https://pubmed.ncbi.nlm.nih.gov/38612837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPSL,ENSG00000152611,Unsafe,31186450,Calcyphosine-like (CAPSL) is regulated in Multiple Symmetric Lipomatosis and is involved in Adipogenesis.,2019,10.1038/s41598-019-44382-1,https://pubmed.ncbi.nlm.nih.gov/31186450/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPSL,ENSG00000152611,Unsafe,36247523,WGCNA combined with GSVA to explore biomarkers of refractory neocortical epilepsy.,2022,10.1016/j.ibneur.2022.09.010,https://pubmed.ncbi.nlm.nih.gov/36247523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPSL,ENSG00000152611,Unsafe,37511295,"Morphological Observation and Transcriptome Analysis of Ciliogenesis in Urechis unicinctus (Annelida, Echiura).",2023,10.3390/ijms241411537,https://pubmed.ncbi.nlm.nih.gov/37511295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPSL,ENSG00000152611,Unsafe,18563381,Study of the association between the CAPSL-IL7R locus and type 1 diabetes.,2008,10.1007/s00125-008-1070-4,https://pubmed.ncbi.nlm.nih.gov/18563381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPSL,ENSG00000152611,Unsafe,22654555,The genetic basis of graves' disease.,2011,10.2174/138920211798120772,https://pubmed.ncbi.nlm.nih.gov/22654555/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPSL,ENSG00000152611,Unsafe,18927125,IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells.,2009,10.1093/hmg/ddn342,https://pubmed.ncbi.nlm.nih.gov/18927125/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CAPSL,ENSG00000152611,Unsafe,19956106,Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families.,2009,10.1038/gene.2009.96,https://pubmed.ncbi.nlm.nih.gov/19956106/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,42750190,Lactylation-Driven PROS1-TYRO3-CARF Signaling Promotes Therapy-Induced Senescence Escape and Radioresistance in Meningioma.,2026,10.1002/advs.77818,https://pubmed.ncbi.nlm.nih.gov/42750190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,39696987,CARF regulates the alternative splicing and piwi/piRNA complexes during mouse spermatogenesis through PABPC1.,2024,10.3724/abbs.2024224,https://pubmed.ncbi.nlm.nih.gov/39696987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,42743106,Cyclic tri-adenylate controls a CARF-TM effector in type II Panoptes anti-phage systems.,2026,10.1371/journal.pbio.3003934,https://pubmed.ncbi.nlm.nih.gov/42743106/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,42236624,Predicting an intrinsic conformational twist in Card1: an in silico study.,2026,10.1007/s00894-026-06784-7,https://pubmed.ncbi.nlm.nih.gov/42236624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,41839959,VS-4718 enhances apoptosis induced by low-dose carfilzomib and overcomes carfilzomib resistance in PSMB5-mutated proteasome inhibitor resistant multiple myeloma.,2026,10.1038/s41598-026-43205-4,https://pubmed.ncbi.nlm.nih.gov/41839959/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,41532544,Conformational Transition of the CARF Domain Driven by Binding Free Energy.,2026,10.1021/acs.jcim.5c02521,https://pubmed.ncbi.nlm.nih.gov/41532544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,40188959,Reduced myocardial CARF and the underlying implications in left ventricular noncompaction cardiomyopathy.,2025,10.1016/j.ijcard.2025.133221,https://pubmed.ncbi.nlm.nih.gov/40188959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,41274355,"Ashwagandha withanolides, Withaferin-A, and Withanone for natural interventions in aging and obesity.",2025,10.1016/j.mad.2025.112126,https://pubmed.ncbi.nlm.nih.gov/41274355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,40619590,Phosphorylation-Dependent Stabilization of Collaborator of ARF (CARF) Suppresses Lymphoma Cell Proliferation.,2025,10.1002/advs.202416687,https://pubmed.ncbi.nlm.nih.gov/40619590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,41416522,CARF-HAD phosphatase effectors provide immunity during the type III-A CRISPR-Cas response.,2025,10.1093/nar/gkaf1363,https://pubmed.ncbi.nlm.nih.gov/41416522/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,41917262,Mechanistic basis for selective Csm6-2 activation by cyclic penta-adenylate in a type III CRISPR-Cas system.,2026,10.1038/s44318-026-00767-3,https://pubmed.ncbi.nlm.nih.gov/41917262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,42868537,Repurposing Type III CRISPR-Cas as Modular Cellular RNA Biosensors.,2026,10.1021/acssensors.6c03012,https://pubmed.ncbi.nlm.nih.gov/42868537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,41107544,The twist-and-squeeze activation of CARF-fused adenosine deaminase by cyclic oligoadenylates.,2025,10.1038/s44318-025-00578-y,https://pubmed.ncbi.nlm.nih.gov/41107544/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,40794864,Cyclic tetraadenylate binding induces dimerization of protein dimers to activate a CRISPR-associated PIN nuclease.,2025,10.1093/nar/gkaf744,https://pubmed.ncbi.nlm.nih.gov/40794864/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,42890341,"Cross-trait genetic architecture of intracerebral hemorrhage highlights convergent vascular, hematologic and lipid pathways.",2026,10.1016/j.metop.2026.100502,https://pubmed.ncbi.nlm.nih.gov/42890341/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,41841492,Structural and functional insights into the adenosine deaminase of the type III-B CRISPR-Cas system.,2026,10.1093/nar/gkag231,https://pubmed.ncbi.nlm.nih.gov/41841492/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,41911342,The CRISPR ring nuclease Csx15 oligomerises on cyclic nucleotide binding to regulate antiviral defence.,2026,10.1042/bcj20260019,https://pubmed.ncbi.nlm.nih.gov/41911342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,40598890,CARF-dependent preferential RNA cleavage by Csm6 increases drug susceptibility of mycobacteria.,2025,10.1093/nar/gkaf622,https://pubmed.ncbi.nlm.nih.gov/40598890/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,39596320,Molecular Insights into the Inhibition of Lipid Accumulation in Hepatocytes by Unique Extracts of Ashwagandha.,2024,10.3390/ijms252212256,https://pubmed.ncbi.nlm.nih.gov/39596320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,39415972,Fertility restorer gene CaRf and PepperSNP50K provide a promising breeding system for hybrid pepper.,2024,10.1093/hr/uhae223,https://pubmed.ncbi.nlm.nih.gov/39415972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,42828730,Veterans Health Administration Pain Management Quality Improvement in a Post-Commission on Accreditation for Rehabilitation Facilities Era.,2026,10.1093/milmed/usag443,https://pubmed.ncbi.nlm.nih.gov/42828730/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,40208959,Cat1 forms filament networks to degrade NAD&lt;sup&gt;+&lt;/sup&gt; during the type III CRISPR-Cas antiviral response.,2025,10.1126/science.adv9045,https://pubmed.ncbi.nlm.nih.gov/40208959/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,39471810,The CRISPR-associated adenosine deaminase Cad1 converts ATP to ITP to provide antiviral immunity.,2024,10.1016/j.cell.2024.10.002,https://pubmed.ncbi.nlm.nih.gov/39471810/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,40324171,Characterization and Evaluation of Department of Veterans Affairs Commission on Accreditation of Rehabilitation Facilities-Accredited Interdisciplinary Pain Rehabilitation Programs: Protocol for a Mixed Methods Program Evaluation.,2025,10.2196/72091,https://pubmed.ncbi.nlm.nih.gov/40324171/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,38200316,The CRISPR effector Cam1 mediates membrane depolarization for phage defence.,2024,10.1038/s41586-023-06902-y,https://pubmed.ncbi.nlm.nih.gov/38200316/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,40960892,Comparing Two Models of Transition from Inpatient Rehabilitation Following Traumatic Brain Injury: A Pragmatic Comparative Effectiveness Trial.,2026,10.1177/08977151251374298,https://pubmed.ncbi.nlm.nih.gov/40960892/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,37048142,Fatty Acid Excess Dysregulates CARF to Initiate the Development of Hepatic Steatosis.,2023,10.3390/cells12071069,https://pubmed.ncbi.nlm.nih.gov/37048142/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,36419420,Enzymatic properties of CARF-domain proteins in Synechocystis sp. PCC 6803.,2022,10.3389/fmicb.2022.1046388,https://pubmed.ncbi.nlm.nih.gov/36419420/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,37949766,Type III CRISPR-Cas: beyond the Cas10 effector complex.,2024,10.1016/j.tibs.2023.10.006,https://pubmed.ncbi.nlm.nih.gov/37949766/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,29805768,Efficacy and safety of carfilzomib in relapsed and/or refractory multiple myeloma: systematic review and meta-analysis of 14 trials.,2018,10.18632/oncotarget.25281,https://pubmed.ncbi.nlm.nih.gov/29805768/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,32286347,Soyasapogenol-A targets CARF and results in suppression of tumor growth and metastasis in p53 compromised cancer cells.,2020,10.1038/s41598-020-62953-5,https://pubmed.ncbi.nlm.nih.gov/32286347/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,32544385,CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection.,2020,10.1016/j.cell.2020.05.019,https://pubmed.ncbi.nlm.nih.gov/32544385/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,32735657,"Evolutionary and functional classification of the CARF domain superfamily, key sensors in prokaryotic antivirus defense.",2020,10.1093/nar/gkaa635,https://pubmed.ncbi.nlm.nih.gov/32735657/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,32221291,Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6.,2020,10.1038/s41467-020-15334-5,https://pubmed.ncbi.nlm.nih.gov/32221291/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CARF,ENSG00000138380,Unsafe,35038453,Structural basis of cyclic oligoadenylate binding to the transcription factor Csa3 outlines cross talk between type III and type I CRISPR systems.,2022,10.1016/j.jbc.2022.101591,https://pubmed.ncbi.nlm.nih.gov/35038453/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,41543154,&lt;p&gt;Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene&lt;/p&gt;.,2026,10.3892/mmr.2026.13794,https://pubmed.ncbi.nlm.nih.gov/41543154/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,41393904,"Protamine1, 2 and Catsper1: sperm quality and fertility indicators in Stallions.",2025,10.1590/1984-3143-ar2025-0040,https://pubmed.ncbi.nlm.nih.gov/41393904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,42723592,Testicular toll with viral intrusion: Molecular insights into the impact of chronic HIV infection on male fertility.,2026,10.1002/ctm2.70815,https://pubmed.ncbi.nlm.nih.gov/42723592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,39668395,Intracellular domain of CATSPER1 could serve as a cytoplasmic platform for redox processes in mammalian sperm.,2025,10.5713/ab.24.0631,https://pubmed.ncbi.nlm.nih.gov/39668395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,42853877,A histidine-mediated supramolecular mechanism links temperature and pH activation of the sperm channel CatSper.,2026,10.1371/journal.pbio.3003776,https://pubmed.ncbi.nlm.nih.gov/42853877/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,41762345,"Intraepididymal platelet-rich plasma improves semen cryoresistance via antioxidant, lipid and molecular modulation during the non-breeding season in rams.",2026,10.1007/s11259-026-11130-6,https://pubmed.ncbi.nlm.nih.gov/41762345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,40701176,Acrosomal exocytosis is compromised in CATSPER1 KO mouse sperm.,2025,10.1530/rep-24-0486,https://pubmed.ncbi.nlm.nih.gov/40701176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,41271765,ARMH2 is a cytosolic component of CatSper crucial for sperm function.,2025,10.1038/s41467-025-65952-0,https://pubmed.ncbi.nlm.nih.gov/41271765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,41115892,Identifying potential genetic biomarkers for sperm dysfunction through whole-genome sequencing.,2025,10.1038/s41598-025-23897-w,https://pubmed.ncbi.nlm.nih.gov/41115892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,42725875,Transmembrane protein 196-mediated regulation of CatSper channel through STAT3 phosphorylation influences sperm motility in mammals.,2026,10.4103/aja202610,https://pubmed.ncbi.nlm.nih.gov/42725875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,41568585,SPINK3-Sperm Interaction Determines a Stable Sperm Subpopulation With Intact CatSper Channel.,2026,10.1002/jcp.70138,https://pubmed.ncbi.nlm.nih.gov/41568585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,37850157,"Inhibition of Autophagy in Heat-Stressed Sperm of Adult Mice: A Possible Role of Catsper1, 2 Channel Proteins.",2023,10.1155/2023/6890815,https://pubmed.ncbi.nlm.nih.gov/37850157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,35897646,Down Regulation of Catsper1 Expression by Calmodulin Inhibitor (Calmidazolium): Possible Implications for Fertility.,2022,10.3390/ijms23158070,https://pubmed.ncbi.nlm.nih.gov/35897646/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,38970681,Sperm-Specific CatSper is Not Conserved in All Vertebrates and May Not be the Only Progesterone-Responsive Ion Channel Present in Sperm.,2024,10.1007/s00232-024-00316-1,https://pubmed.ncbi.nlm.nih.gov/38970681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,39355314,Impact of chronic opioid on cognitive function and spermatogenesis in rat: An experimental study.,2024,10.18502/ijrm.v22i7.16971,https://pubmed.ncbi.nlm.nih.gov/39355314/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,39733410,The G Protein-Coupled Receptor-Related Gene Signatures for Diagnosis and Prognosis in Glioblastoma: A Deep Learning Model Using RNA-Seq Data.,2024,10.31557/apjcp.2024.25.12.4201,https://pubmed.ncbi.nlm.nih.gov/39733410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,39449422,"Altered Expression of Thyroid- and Calcium Ion Channels-Related Genes in Rat Testes by Short-Term Exposure to Commercial Herbicides Paraquat or 2,4-D.",2024,10.3390/jox14040081,https://pubmed.ncbi.nlm.nih.gov/39449422/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,36571327,In silico docking analysis of beta-defensin 20 against cation channel sperm-associated protein 1-4 to predict its role in the sperm maturation.,2023,10.4103/aja2022103,https://pubmed.ncbi.nlm.nih.gov/36571327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,42165548,&lt;i&gt;In silico&lt;/i&gt; profiling of date palm pollen phytochemicals: Molecular interactions with sperm-associated proteins and implications for male fertility.,2026,10.1177/02601060261454177,https://pubmed.ncbi.nlm.nih.gov/42165548/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,37957468,"The Detection of CatSper1 and CatSper3 Expression in Men with Normozoospermia and Asthenoteratozoospermia and Its Association with Sperm Parameters, Fertilization Rate, Embryo Quality.",2024,10.1007/s43032-023-01397-4,https://pubmed.ncbi.nlm.nih.gov/37957468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,38449660,Bulk anda single-cell transcriptome profiling reveals the molecular characteristics of T cell-mediated tumor killing in pancreatic cancer.,2024,10.1016/j.heliyon.2024.e27216,https://pubmed.ncbi.nlm.nih.gov/38449660/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,42324862,A Scalable Flow Cytometry Assay to Evaluate CatSper-mediated Ca&lt;sup&gt;2+&lt;/sup&gt; Influx Triggered by High-K&lt;sup&gt;+&lt;/sup&gt;/High-pH Stimulation in Mouse Sperm.,2026,10.1111/andr.70294,https://pubmed.ncbi.nlm.nih.gov/42324862/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,40478882,Dynamic relocation of PKA regulatory subunits during sperm capacitation: Linking PKA to the CatSper signaling complex.,2025,10.1073/pnas.2501741122,https://pubmed.ncbi.nlm.nih.gov/40478882/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,34407557,Astaxanthin Induces the Expression of CatSper1 Gene and Protects Sperms in Toxicity Induced by Cadmium in Mice.,2021,10.1055/a-1553-3265,https://pubmed.ncbi.nlm.nih.gov/34407557/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,34953956,TET1 mediated male reproductive toxicity induced by Bisphenol A through Catsper-Ca2+ signaling pathway.,2022,10.1016/j.envpol.2021.118739,https://pubmed.ncbi.nlm.nih.gov/34953956/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,35610596,Mast cell marker gene signature in head and neck squamous cell carcinoma.,2022,10.1186/s12885-022-09673-3,https://pubmed.ncbi.nlm.nih.gov/35610596/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,33456575,Roles of CatSper channels in the pathogenesis of asthenozoospermia and the therapeutic effects of acupuncture-like treatment on asthenozoospermia.,2021,10.7150/thno.51869,https://pubmed.ncbi.nlm.nih.gov/33456575/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,34936255,Up-regulation of Arl4a gene expression by broccoli aqueous extract is associated with improved spermatogenesis in mouse testes.,2021,10.7705/biomedica.5962,https://pubmed.ncbi.nlm.nih.gov/34936255/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,25993432,Construction of a catsper1 DNA vaccine and its antifertility effect on male mice.,2015,10.1371/journal.pone.0127508,https://pubmed.ncbi.nlm.nih.gov/25993432/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,32872134,Differential Expression and miRNA-Gene Interactions in Early and Late Mild Cognitive Impairment.,2020,10.3390/biology9090251,https://pubmed.ncbi.nlm.nih.gov/32872134/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,23148924,"Down-regulation of CatSper1 channel in epididymal spermatozoa contributes to the pathogenesis of asthenozoospermia, whereas up-regulation of the channel by Sheng-Jing-San treatment improves the sperm motility of asthenozoospermia in rats.",2013,10.1016/j.fertnstert.2012.10.030,https://pubmed.ncbi.nlm.nih.gov/23148924/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,23881332,In vivo influence of sodium fluoride on sperm chemotaxis in male mice.,2014,10.1007/s00204-013-1099-0,https://pubmed.ncbi.nlm.nih.gov/23881332/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,22196715,Immunization of male mice with B-cell epitopes in transmembrane domains of CatSper1 inhibits fertility.,2012,10.1016/j.fertnstert.2011.11.043,https://pubmed.ncbi.nlm.nih.gov/22196715/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,27627854,Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models.,2016,10.1038/srep33589,https://pubmed.ncbi.nlm.nih.gov/27627854/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,23508510,Investigation in vitro Expression of CatSper Sub Fragment followed by Production of Polyclonal Antibody: Potential Candidate for The Next Generation of Non Hormonal Contraceptive.,2012,,https://pubmed.ncbi.nlm.nih.gov/23508510/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,17347248,Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility.,2007,10.1093/molehr/gam009,https://pubmed.ncbi.nlm.nih.gov/17347248/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,16625279,The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa.,2006,10.1111/j.1745-7262.2006.00132.x,https://pubmed.ncbi.nlm.nih.gov/16625279/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER1,ENSG00000175294,Unsafe,11595941,A sperm ion channel required for sperm motility and male fertility.,2001,10.1038/35098027,https://pubmed.ncbi.nlm.nih.gov/11595941/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,41898800,"The Expression of Kisspeptin Receptor, Catsper 3 and Acrosome Integrity in Oligozoospermic and Normozoospermic Individuals.",2026,10.3390/genes17030266,https://pubmed.ncbi.nlm.nih.gov/41898800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,40865603,The Catsper3 promoter activity is regulated by the cAMP-Response Element Modulator tau (CREMτ) and the cAMP-Response Element Binding protein 1A (CREBA) transcription factors.,2025,10.1016/j.bbagrm.2025.195114,https://pubmed.ncbi.nlm.nih.gov/40865603/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,41762345,"Intraepididymal platelet-rich plasma improves semen cryoresistance via antioxidant, lipid and molecular modulation during the non-breeding season in rams.",2026,10.1007/s11259-026-11130-6,https://pubmed.ncbi.nlm.nih.gov/41762345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,41850444,Benzo[a]pyrene lowers the sperm quality in male rats by downregulating the expression of ZMYND15 and ZMYND10.,2026,10.1016/j.reprotox.2026.109225,https://pubmed.ncbi.nlm.nih.gov/41850444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,40898687,CFAP300 loss-of-function variant causes primary ciliary dyskinesia and male infertility via disrupting sperm flagellar assembly and acrosome formation.,2025,10.4103/aja202556,https://pubmed.ncbi.nlm.nih.gov/40898687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,38020915,CatSper mediates not only chemotactic behavior but also the motility of ascidian sperm.,2023,10.3389/fcell.2023.1136537,https://pubmed.ncbi.nlm.nih.gov/38020915/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,37957468,"The Detection of CatSper1 and CatSper3 Expression in Men with Normozoospermia and Asthenoteratozoospermia and Its Association with Sperm Parameters, Fertilization Rate, Embryo Quality.",2024,10.1007/s43032-023-01397-4,https://pubmed.ncbi.nlm.nih.gov/37957468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,35886074,Further Insights on RNA Expression and Sperm Motility.,2022,10.3390/genes13071291,https://pubmed.ncbi.nlm.nih.gov/35886074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,39506588,Identification of Potential Biomarkers Associated with Spermatogenesis in Azoospermia.,2024,10.7754/clin.lab.2024.240541,https://pubmed.ncbi.nlm.nih.gov/39506588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,33350607,Patient with CATSPER3 mutations-related failure of sperm acrosome reaction with successful pregnancy outcome from intracytoplasmic sperm injection (ICSI).,2021,10.1002/mgg3.1579,https://pubmed.ncbi.nlm.nih.gov/33350607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,38038214,"Reduction of cryopreservation-induced structural, functional and molecular damages in ram sperm by hydrated C60 fullerene.",2024,10.1111/rda.14513,https://pubmed.ncbi.nlm.nih.gov/38038214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,34585662,"Effect of freeze-thawing process on lipid peroxidation, miRNAs, ion channels, apoptosis and global DNA methylation in ram spermatozoa.",2021,10.1071/rd21091,https://pubmed.ncbi.nlm.nih.gov/34585662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,21970684,"Molecular cloning, spatial and temporal expression analysis of CatSper genes in the Chinese Meishan pigs.",2011,10.1186/1477-7827-9-132,https://pubmed.ncbi.nlm.nih.gov/21970684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,29492471,Ion channel gene expressions in infertile men: A case-control study.,2017,10.29252/ijrm.15.12.749,https://pubmed.ncbi.nlm.nih.gov/29492471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,17227862,Wrath of the wraiths of CatSper3 and CatSper4.,2007,10.1073/pnas.0610909104,https://pubmed.ncbi.nlm.nih.gov/17227862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,17344468,Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse.,2007,10.1095/biolreprod.107.060186,https://pubmed.ncbi.nlm.nih.gov/17344468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,21255775,A comprehensive gene mutation screen in men with asthenozoospermia.,2011,10.1016/j.fertnstert.2010.11.067,https://pubmed.ncbi.nlm.nih.gov/21255775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,16107607,Catsper3 and catsper4 encode two cation channel-like proteins exclusively expressed in the testis.,2005,10.1095/biolreprod.105.045468,https://pubmed.ncbi.nlm.nih.gov/16107607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,12932298,Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis.,2003,10.1186/1477-7827-1-53,https://pubmed.ncbi.nlm.nih.gov/12932298/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,17347248,Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility.,2007,10.1093/molehr/gam009,https://pubmed.ncbi.nlm.nih.gov/17347248/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPER3,ENSG00000152705,Unsafe,12646162,Cloning of a novel one-repeat calcium channel-like gene.,2003,10.1016/s0006-291x(03)00276-6,https://pubmed.ncbi.nlm.nih.gov/12646162/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERB,ENSG00000133962,Unsafe,42898155,Identifying a &lt;i&gt;CATSPERB&lt;/i&gt; Variants in unexplained male infertility through familial exome sequencing.,2026,10.34172/bi.31216,https://pubmed.ncbi.nlm.nih.gov/42898155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERB,ENSG00000133962,Unsafe,39210919,Prochloraz induced alterations in the expression of mRNA in the reproductive system of male offspring mice.,2024,10.7717/peerj.17917,https://pubmed.ncbi.nlm.nih.gov/39210919/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERB,ENSG00000133962,Unsafe,36672807,Identification of Circular RNAs of Testis and Caput Epididymis and Prediction of Their Potential Functional Roles in Donkeys.,2022,10.3390/genes14010066,https://pubmed.ncbi.nlm.nih.gov/36672807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERB,ENSG00000133962,Unsafe,34867976,Novel Tumor-Specific Antigens for Immunotherapy Identified From Multi-omics Profiling in Thymic Carcinomas.,2021,10.3389/fimmu.2021.748820,https://pubmed.ncbi.nlm.nih.gov/34867976/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERB,ENSG00000133962,Unsafe,32031713,Apocrine glands are bystanders in hidradenitis suppurativa and their involvement is gender specific.,2020,10.1111/jdv.16264,https://pubmed.ncbi.nlm.nih.gov/32031713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERB,ENSG00000133962,Unsafe,33247676,Pan-Cancer Multiomics Analysis of TC2N Gene Suggests its Important Role(s) in Tumourigenesis of Many Cancers.,2020,10.31557/apjcp.2020.21.11.3199,https://pubmed.ncbi.nlm.nih.gov/33247676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERB,ENSG00000133962,Unsafe,19516020,"A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein.",2009,10.1095/biolreprod.109.077107,https://pubmed.ncbi.nlm.nih.gov/19516020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERB,ENSG00000133962,Unsafe,29213343,Exome sequencing characterizes the somatic mutation spectrum of early serrated lesions in a patient with serrated polyposis syndrome (SPS).,2017,10.1186/s13053-017-0082-9,https://pubmed.ncbi.nlm.nih.gov/29213343/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERB,ENSG00000133962,Unsafe,25927035,"Relationship between CATSPERB, NR5A2 gene polymorphisms and Peak Bone Mineral Density in College Students in China.",2014,,https://pubmed.ncbi.nlm.nih.gov/25927035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERB,ENSG00000133962,Unsafe,27220576,[Mutation screening for the causative gene in a four-generation Chinese pedigree with progressive cardiac conduction defect].,2016,10.3760/cma.j.issn.0253-3758.2016.05.009,https://pubmed.ncbi.nlm.nih.gov/27220576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERB,ENSG00000133962,Unsafe,20164292,Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women.,2010,10.1210/jc.2009-1903,https://pubmed.ncbi.nlm.nih.gov/20164292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERD,ENSG00000174898,Unsafe,42612345,Mineral-driven molecular signatures of energy metabolism underpin sperm motility in buffalo.,2026,10.1016/j.anireprosci.2026.108307,https://pubmed.ncbi.nlm.nih.gov/42612345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERD,ENSG00000174898,Unsafe,42518043,"Cross-species comparative transcriptomic analysis of spermatozoa reveals species-specific regulatory networks linked to fertilization-associated genes in cattle, sheep and goats.",2026,10.1007/s11427-024-3211-6,https://pubmed.ncbi.nlm.nih.gov/42518043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERD,ENSG00000174898,Unsafe,41100162,Cross-species insemination reveals mouse sperm ability to enter and cross the fish micropyle.,2025,10.7554/elife.106303,https://pubmed.ncbi.nlm.nih.gov/41100162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERD,ENSG00000174898,Unsafe,41300787,Genome-Wide Association Study of First-Parity Reproductive Traits in Suzi Pig.,2025,10.3390/genes16111335,https://pubmed.ncbi.nlm.nih.gov/41300787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERD,ENSG00000174898,Unsafe,36672807,Identification of Circular RNAs of Testis and Caput Epididymis and Prediction of Their Potential Functional Roles in Donkeys.,2022,10.3390/genes14010066,https://pubmed.ncbi.nlm.nih.gov/36672807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERD,ENSG00000174898,Unsafe,35330493,Neoexpression of JUNO in Oral Tumors Is Accompanied with the Complete Suppression of Four Other Genes and Suggests the Application of New Biomarker Tools.,2022,10.3390/jpm12030494,https://pubmed.ncbi.nlm.nih.gov/35330493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERD,ENSG00000174898,Unsafe,36048845,Exome sequencing and functional analyses revealed CETN1 variants leads to impaired cell division and male fertility.,2023,10.1093/hmg/ddac216,https://pubmed.ncbi.nlm.nih.gov/36048845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERD,ENSG00000174898,Unsafe,33100131,Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans.,2021,10.1080/15592294.2020.1827717,https://pubmed.ncbi.nlm.nih.gov/33100131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERD,ENSG00000174898,Unsafe,32126384,Identification of key genes associated with spermatogenesis arrest in fox hybrids using weighted gene co-expression network analysis.,2020,10.1016/j.theriogenology.2020.02.029,https://pubmed.ncbi.nlm.nih.gov/32126384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERD,ENSG00000174898,Unsafe,25481096,Identification of a novel isoform of the leukemia-associated MLLT1 (ENL/LTG19) protein.,2015,10.1016/j.gep.2014.11.003,https://pubmed.ncbi.nlm.nih.gov/25481096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERD,ENSG00000174898,Unsafe,21224844,A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.,2011,10.1038/ncomms1153,https://pubmed.ncbi.nlm.nih.gov/21224844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERE,ENSG00000179397,Unsafe,39627815,Genome-wide DNA methylation analysis reveals a unique methylation pattern for pleural mesothelioma compared to healthy pleura and other lung diseases.,2024,10.1186/s13148-024-01790-z,https://pubmed.ncbi.nlm.nih.gov/39627815/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERE,ENSG00000179397,Unsafe,30239785,Homozygous in-frame deletion in CATSPERE in a man producing spermatozoa with loss of CatSper function and compromised fertilizing capacity.,2018,10.1093/humrep/dey278,https://pubmed.ncbi.nlm.nih.gov/30239785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERE,ENSG00000179397,Unsafe,28226241,CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility.,2017,10.7554/elife.23082,https://pubmed.ncbi.nlm.nih.gov/28226241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERG,ENSG00000099338,Unsafe,39506588,Identification of Potential Biomarkers Associated with Spermatogenesis in Azoospermia.,2024,10.7754/clin.lab.2024.240541,https://pubmed.ncbi.nlm.nih.gov/39506588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERG,ENSG00000099338,Unsafe,33095540,"Genome-wide association study of high-sensitivity C-reactive protein, D-dimer, and interleukin-6 levels in multiethnic HIV+ cohorts.",2021,10.1097/qad.0000000000002738,https://pubmed.ncbi.nlm.nih.gov/33095540/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERG,ENSG00000099338,Unsafe,19516020,"A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein.",2009,10.1095/biolreprod.109.077107,https://pubmed.ncbi.nlm.nih.gov/19516020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERZ,ENSG00000219435,Unsafe,42913173,Maternal antibody repertoires in preeclampsia revealed by phage immunoprecipitation sequencing.,2026,10.1016/j.jaut.2026.103645,https://pubmed.ncbi.nlm.nih.gov/42913173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERZ,ENSG00000219435,Unsafe,28226241,CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility.,2017,10.7554/elife.23082,https://pubmed.ncbi.nlm.nih.gov/28226241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERZ,ENSG00000219435,Unsafe,37874861,Integrated single cell transcriptome sequencing analysis reveals species-specific genes and molecular pathways for pig spermiogenesis.,2023,10.1111/rda.14493,https://pubmed.ncbi.nlm.nih.gov/37874861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERZ,ENSG00000219435,Unsafe,30550884,Proteomic analyses reveal lower expression of TEX40 and ATP6V0A2 proteins related to calcium ion entry and acrosomal acidification in asthenozoospermic males.,2019,10.1016/j.lfs.2018.12.016,https://pubmed.ncbi.nlm.nih.gov/30550884/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERZ,ENSG00000219435,Unsafe,30239785,Homozygous in-frame deletion in CATSPERE in a man producing spermatozoa with loss of CatSper function and compromised fertilizing capacity.,2018,10.1093/humrep/dey278,https://pubmed.ncbi.nlm.nih.gov/30239785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERZ,ENSG00000219435,Unsafe,21949640,ESRRA-C11orf20 is a recurrent gene fusion in serous ovarian carcinoma.,2011,10.1371/journal.pbio.1001156,https://pubmed.ncbi.nlm.nih.gov/21949640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CATSPERZ,ENSG00000219435,Unsafe,24504521,Low frequency of ESRRA-C11orf20 fusion gene in ovarian carcinomas.,2014,10.1371/journal.pbio.1001784,https://pubmed.ncbi.nlm.nih.gov/24504521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,42472112,E3 ubiquitin-ligase Hakai regulates LRP4 stability and Wnt/β-catenin signalling in colorectal cancer cells.,2026,10.1016/j.isci.2026.116743,https://pubmed.ncbi.nlm.nih.gov/42472112/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,39833727,Beyond destruction: emerging roles of the E3 ubiquitin ligase Hakai.,2025,10.1186/s11658-025-00693-y,https://pubmed.ncbi.nlm.nih.gov/39833727/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,41310336,Functional and clinical significance of the RNA m&lt;sup&gt;6&lt;/sup&gt;A methyltransferase complex in breast cancer.,2025,10.1038/s41523-025-00861-5,https://pubmed.ncbi.nlm.nih.gov/41310336/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,41884161,"Machine Learning and Experimental Validation of m6A RNA Methylation Related Signatures for Risk Prediction, Diagnostic Biomarkers, and Immune Subtypes in Chronic Kidney Disease.",2026,10.2147/jir.s553934,https://pubmed.ncbi.nlm.nih.gov/41884161/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,38339195,Stratification of Colorectal Patients Based on Survival Analysis Shows the Value of Consensus Molecular Subtypes and Reveals the CBLL1 Gene as a Biomarker of CMS2 Tumours.,2024,10.3390/ijms25031919,https://pubmed.ncbi.nlm.nih.gov/38339195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,42001838,Chromones from Saposhnikovia divaricata modulate m&lt;sup&gt;6&lt;/sup&gt;A RNA methylation-mediated macrophage polarization by targeting CBLL1 to ameliorate RA.,2026,10.1016/j.phymed.2026.158172,https://pubmed.ncbi.nlm.nih.gov/42001838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,42163948,Genetic Identification of Potential Drug Targets for Dental Caries: A Mendelian Randomization Study.,2026,10.1002/hsr2.72546,https://pubmed.ncbi.nlm.nih.gov/42163948/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,42724890,Development of m6A-related prognostic models for survival in lung squamous cell carcinoma with different PD-L1 expression levels.,2026,10.21037/tcr-2026-0829,https://pubmed.ncbi.nlm.nih.gov/42724890/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,42372047,Decoding The Epitranscriptome: In Silico Insights Into m6A Regulatory Network In Breast Cancer.,2026,10.3791/70545,https://pubmed.ncbi.nlm.nih.gov/42372047/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,42074576,Integrative Analysis and Experimental Validation Identify Potential m6A-Related Biomarkers for Osteoporosis.,2026,10.3390/genes17040458,https://pubmed.ncbi.nlm.nih.gov/42074576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,40664668,DDX39B K63-linked ubiquitination mediated by TRIM28 promotes NSCLC metastasis by enhancing ECAD lysosomal degradation.,2025,10.1038/s41392-025-02305-9,https://pubmed.ncbi.nlm.nih.gov/40664668/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,41209572,Comprehensive Analysis of Aberrant m6A RNA Modifications Identifies Prognostic Biomarkers in Non-Small Cell Lung Cancer.,2025,10.7150/ijms.119651,https://pubmed.ncbi.nlm.nih.gov/41209572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,39012313,CBLL1 promotes endometrial stromal cell senescence via inhibiting PTEN in recurrent spontaneous abortion.,2024,10.1096/fj.202400972r,https://pubmed.ncbi.nlm.nih.gov/39012313/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,42092754,DNASE1L3 functions as a significant metastatic suppressor by attenuating MYH9/β-catenin/c-Jun/LncRNA-KDM4A-induced E-cadherin ubiquitination degradation in nasopharyngeal carcinoma.,2026,10.1186/s11658-026-00911-1,https://pubmed.ncbi.nlm.nih.gov/42092754/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,36266428,Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation and cancer bowel disease.,2022,10.1038/s41598-022-22295-w,https://pubmed.ncbi.nlm.nih.gov/36266428/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,42184983,Ectopic expression of the transcriptional regulator and m6A writer complex member HIZ1 impacts development in Arabidopsis.,2026,10.1093/plphys/kiag303,https://pubmed.ncbi.nlm.nih.gov/42184983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,39764917,Steroid sulfatase suppresses keratinization by inducing proteasomal degradation of E-cadherin via Hakai regulation.,2025,10.1016/j.bbamcr.2025.119898,https://pubmed.ncbi.nlm.nih.gov/39764917/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,42172677,Evidence for an early cadherin-catenin interaction network in ctenophores.,2026,10.1093/molbev/msag123,https://pubmed.ncbi.nlm.nih.gov/42172677/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,38062063,CBLL1 is hypomethylated and correlates with cortical thickness in transgender men before gender affirming hormone treatment.,2023,10.1038/s41598-023-48782-2,https://pubmed.ncbi.nlm.nih.gov/38062063/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,41898277,Mediation Role of Gut Microbiota in the Causal Relationship Between m6A Regulatory Genes and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Mendelian Randomization Study.,2026,10.3390/biomedicines14030630,https://pubmed.ncbi.nlm.nih.gov/41898277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,36937208,Daurisoline Inhibiting Tumor Angiogenesis and Epithelial-Mesenchymal Transition in Bladder Cancer by Mediating HAKAI Protein Stability.,2022,10.5812/ijpr-129798,https://pubmed.ncbi.nlm.nih.gov/36937208/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,36261786,"Study on the prognosis, immune and drug resistance of m6A-related genes in lung cancer.",2022,10.1186/s12859-022-04984-5,https://pubmed.ncbi.nlm.nih.gov/36261786/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,37972699,Characteristics of n6-methyladenosine (m6A) regulators and role of FTO/TNC in scleroderma.,2024,10.1016/j.gene.2023.147989,https://pubmed.ncbi.nlm.nih.gov/37972699/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,38049811,Key m6A regulators mediated methylation modification pattern and immune infiltration characterization in hepatic ischemia-reperfusion injury.,2023,10.1186/s12920-023-01751-0,https://pubmed.ncbi.nlm.nih.gov/38049811/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,40177651,Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development.,2025,10.1515/med-2025-1167,https://pubmed.ncbi.nlm.nih.gov/40177651/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,36048273,Gene signature of m6A-related targets to predict prognosis and immunotherapy response in ovarian cancer.,2023,10.1007/s00432-022-04162-3,https://pubmed.ncbi.nlm.nih.gov/36048273/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,37474926,Knockdown of RBM15 inhibits tumor progression and the JAK-STAT signaling pathway in cervical cancer.,2023,10.1186/s12885-023-11163-z,https://pubmed.ncbi.nlm.nih.gov/37474926/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,40522389,A multi-type programmed cell death gene signature predicts survival and reveals therapeutic targets in osteosarcoma.,2025,10.1007/s12672-025-02944-y,https://pubmed.ncbi.nlm.nih.gov/40522389/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,37684273,The synergistic effect of EMT regulators and m6A modification on prognosis-related immunological signatures for ovarian cancer.,2023,10.1038/s41598-023-41554-y,https://pubmed.ncbi.nlm.nih.gov/37684273/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLL1,ENSG00000105879,Unsafe,36762188,N6-methyladenosine modulation classes and immune microenvironment regulation in ischemic stroke.,2022,10.3389/fnmol.2022.1013076,https://pubmed.ncbi.nlm.nih.gov/36762188/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,42687380,AAV-mediated CBLN1 replacement rescues hereditary ataxia caused by bi-allelic CBLN1 variants.,2026,10.1016/j.ymthe.2026.09.003,https://pubmed.ncbi.nlm.nih.gov/42687380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,42358604,Transsynaptic complex dysfunction in the hippocampus of Alzheimer's disease patients.,2026,10.3389/fnagi.2026.1837327,https://pubmed.ncbi.nlm.nih.gov/42358604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,41144370,CBLN1 inhibits the inflammatory response by targeting GluD1 thereby alleviating resiniferatoxin-induced postherpetic neuralgia in mice.,2026,10.1093/jnen/nlaf109,https://pubmed.ncbi.nlm.nih.gov/41144370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,42737479,Molecular and Cellular Mechanisms of Synaptogenesis and Synaptic Refinement During Cerebellar Circuit Formation.,2026,10.3390/ijms27177576,https://pubmed.ncbi.nlm.nih.gov/42737479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,41147487,Trans-synaptic signaling through GRID1/glutamate receptor delta-1 and CBLN1/cerebellin-1 facilitates autophagic flux in central amygdala and prevents chronic pain.,2025,10.1080/15548627.2025.2574968,https://pubmed.ncbi.nlm.nih.gov/41147487/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,41995212,Structural Architecture and Evolutionary Conservation of Cerebellin-Mediated Trans-Synaptic Signaling.,2026,10.1002/syn.70045,https://pubmed.ncbi.nlm.nih.gov/41995212/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,40593183,Restoration of glutamate delta 1 signaling and excitatory inhibitory imbalance in the central amygdala in cisplatin induced neuropathic pain by cerebellin 1.,2025,10.1038/s41598-025-06073-y,https://pubmed.ncbi.nlm.nih.gov/40593183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,40393806,Atypical Cadherin FAT2 Is Required for Synaptic Integrity and Motor Behaviors.,2025,10.1523/jneurosci.2345-24.2025,https://pubmed.ncbi.nlm.nih.gov/40393806/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,39890638,D-Serine disrupts Cbln1 and GluD1 interaction and affects Cbln1-dependent synaptic effects and nocifensive responses in the central amygdala.,2025,10.1007/s00018-024-05554-z,https://pubmed.ncbi.nlm.nih.gov/39890638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,42270762,GluD1 is localized at cholinergic synapses and is an acetylcholine receptor.,2026,10.1038/s41380-026-03675-4,https://pubmed.ncbi.nlm.nih.gov/42270762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,42465740,&lt;i&gt;Blomia tropicalis&lt;/i&gt; allergens induce lung DNA methylation changes in neuroimmune genes in a mouse model of airway inflammation.,2026,10.3389/fimmu.2026.1775662,https://pubmed.ncbi.nlm.nih.gov/42465740/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,38044332,Intravenous recombinant cerebellin 1 treatment restores signalling by spinal glutamate delta 1 receptors and mitigates chronic pain.,2024,10.1111/bph.16296,https://pubmed.ncbi.nlm.nih.gov/38044332/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,38205248,YTHDF3 modulates the Cbln1 level by recruiting BTG2 and is implicated in the impaired cognition of prenatal hypoxia offspring.,2024,10.1016/j.isci.2023.108703,https://pubmed.ncbi.nlm.nih.gov/38205248/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,40143207,Identification of Deregulated miRNAs and mRNAs Involved in Tumorigenesis and Detection of Glioblastoma Patients Applying Next-Generation RNA Sequencing.,2025,10.3390/ph18030431,https://pubmed.ncbi.nlm.nih.gov/40143207/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,41725537,"Integrated New Approach Methodologies Reveal the Potential Role of 2,7-Dibromocarbazole in Parkinson's Disease via Monoamine Oxidase B Inhibition and Dopaminergic Dysfunction.",2026,10.1021/acs.est.5c14167,https://pubmed.ncbi.nlm.nih.gov/41725537/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,36823038,Cbln1 Directs Axon Targeting by Corticospinal Neurons Specifically toward Thoraco-Lumbar Spinal Cord.,2023,10.1523/jneurosci.0710-22.2023,https://pubmed.ncbi.nlm.nih.gov/36823038/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,36395107,Cbln1 regulates axon growth and guidance in multiple neural regions.,2022,10.1371/journal.pbio.3001853,https://pubmed.ncbi.nlm.nih.gov/36395107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,39658623,Stepwise molecular specification of excitatory synapse diversity onto cerebellar Purkinje cells.,2025,10.1038/s41593-024-01826-w,https://pubmed.ncbi.nlm.nih.gov/39658623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,39052831,Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.,2024,10.1073/pnas.2406655121,https://pubmed.ncbi.nlm.nih.gov/39052831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,34111112,Long noncoding RNA PM maintains cerebellar synaptic integrity and Cbln1 activation via Pax6/Mll1-mediated H3K4me3.,2021,10.1371/journal.pbio.3001297,https://pubmed.ncbi.nlm.nih.gov/34111112/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,38706895,Identification of glutamine metabolism-related gene signature to predict colorectal cancer prognosis.,2024,10.7150/jca.91687,https://pubmed.ncbi.nlm.nih.gov/38706895/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,36205393,Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner.,2022,10.7554/elife.78649,https://pubmed.ncbi.nlm.nih.gov/36205393/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,35720126,Comprehensive Analyses of Ferroptosis-Related Alterations and Their Prognostic Significance in Glioblastoma.,2022,10.3389/fmolb.2022.904098,https://pubmed.ncbi.nlm.nih.gov/35720126/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,34685624,Dysfunction of Glutamate Delta-1 Receptor-Cerebellin 1 Trans-Synaptic Signaling in the Central Amygdala in Chronic Pain.,2021,10.3390/cells10102644,https://pubmed.ncbi.nlm.nih.gov/34685624/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,36118901,Bioinformatics searching of diagnostic markers and immune infiltration in polycystic ovary syndrome.,2022,10.3389/fgene.2022.937309,https://pubmed.ncbi.nlm.nih.gov/36118901/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,36814929,Construction and validation of a cuproptosis-related prognostic model for glioblastoma.,2023,10.3389/fimmu.2023.1082974,https://pubmed.ncbi.nlm.nih.gov/36814929/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,34158618,Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors.,2021,10.1038/s41380-021-01187-x,https://pubmed.ncbi.nlm.nih.gov/34158618/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,28297715,Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1.,2017,10.1038/nature21678,https://pubmed.ncbi.nlm.nih.gov/28297715/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,29691328,Genetic Ablation of All Cerebellins Reveals Synapse Organizer Functions in Multiple Regions Throughout the Brain.,2018,10.1523/jneurosci.0360-18.2018,https://pubmed.ncbi.nlm.nih.gov/29691328/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,33762741,The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum.,2021,10.1038/s41418-021-00774-3,https://pubmed.ncbi.nlm.nih.gov/33762741/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBLN1,ENSG00000102924,Unsafe,29782851,Glycosylation of Cblns attenuates their receptor binding.,2018,10.1016/j.brainres.2018.05.022,https://pubmed.ncbi.nlm.nih.gov/29782851/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,42893482,Hepatocyte CBX2 Safeguards Hepatic Lipid Homeostasis by Elevating Ca&lt;sup&gt;2+&lt;/sup&gt;-CaMKK2-AMPK Signaling to Counter MASLD.,2026,10.1002/advs.78372,https://pubmed.ncbi.nlm.nih.gov/42893482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,42882837,H3K27M Mutation Modulates the Antigenic Landscape in Diffuse Midline Glioma.,2026,10.3390/cancers18193142,https://pubmed.ncbi.nlm.nih.gov/42882837/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,42195095,Epigenetic and ncRNA Regulation of CBX2 in Liver Hepatocellular Carcinoma: A Comprehensive Multi-Omics Analysis for Understanding Biological Significance.,2026,10.3390/medicina62050842,https://pubmed.ncbi.nlm.nih.gov/42195095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,41578831,"Chromobox 2 Inhibition: A Novel Activity of Alisertib, an Aurora A Kinase Inhibitor.",2026,10.1158/1535-7163.mct-25-0279,https://pubmed.ncbi.nlm.nih.gov/41578831/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,42438600,Identification of immunopeptides (pHLA) as candidate therapeutic targets in chondrosarcoma.,2026,10.1016/j.jbo.2026.100780,https://pubmed.ncbi.nlm.nih.gov/42438600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,42628813,Environmental endocrine disruptors activate CBX2 to disrupt cholesterol homeostasis in PCOS.,2027,10.1016/j.jsbmb.2026.107104,https://pubmed.ncbi.nlm.nih.gov/42628813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,42082722,Liquid-liquid phase separation of CBX2 regulates lipid raft-mediated extracellular vesicle biogenesis to facilitate ovarian carcinoma metastasis.,2026,10.1038/s41698-026-01409-x,https://pubmed.ncbi.nlm.nih.gov/42082722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,41888115,CBX2 phase-separation contributes to homologous recombination repair and drug resistance in ovarian cancer.,2026,10.1038/s41419-026-08605-4,https://pubmed.ncbi.nlm.nih.gov/41888115/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,41495834,CBX2 promotes cisplatin resistance in ovarian cancer via SIAH2-mediated β-catenin stabilization and ATG9B-dependent autophagy activation.,2026,10.1186/s13048-025-01944-4,https://pubmed.ncbi.nlm.nih.gov/41495834/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,41785860,Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes.,2026,10.1016/j.molcel.2026.02.009,https://pubmed.ncbi.nlm.nih.gov/41785860/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,41423460,CBX2 promoted oral squamous cell carcinoma via increasing CEP55/NF-κB/METTL3/SHP2 signaling induced metastasis/proliferation and angiogenesis.,2025,10.1038/s41598-025-31475-3,https://pubmed.ncbi.nlm.nih.gov/41423460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,42458442,Trophoblast cells rewire the epigenetic landscape of vascular smooth muscle cells to modulate plasticity: a regulatory axis disrupted in intrauterine growth restriction.,2026,10.1186/s12964-026-03042-4,https://pubmed.ncbi.nlm.nih.gov/42458442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,40082555,CBX2 as a therapeutic target in colorectal cancer: insights into the altered chromatin accessibility via RUNX1-CBX2-MAP4K1 axis.,2025,10.1038/s41388-025-03331-1,https://pubmed.ncbi.nlm.nih.gov/40082555/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,42455436,Chromatin-Based Control of Mammalian Sex Determination: Integrating Epigenetic and Metabolic Mechanisms.,2026,10.1007/978-981-92-1439-6_3,https://pubmed.ncbi.nlm.nih.gov/42455436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,40848940,CBX2 and EZH2 cooperatively contribute to 5-Fu resistance in gastric cancer by suppressing ferroptosis via trimethylation of H3k27.,2025,10.1016/j.cellsig.2025.112078,https://pubmed.ncbi.nlm.nih.gov/40848940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,39114365,CBX2 enhances the progression and TMZ chemoresistance of glioma via EZH2-mediated epigenetic silencing of PTEN expression.,2024,10.3389/fphar.2024.1430891,https://pubmed.ncbi.nlm.nih.gov/39114365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,39987187,Integrated bioinformatics investigation and experimental validation reveals the clinical and biological significance of chromobox family in breast cancer.,2025,10.1038/s41598-025-90771-0,https://pubmed.ncbi.nlm.nih.gov/39987187/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,39883845,CBX2 suppresses interferon signaling to diminish tumor immunogenicity via a noncanonical corepressor complex.,2025,10.1073/pnas.2417529122,https://pubmed.ncbi.nlm.nih.gov/39883845/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,39793896,CBX2 promotes cervical cancer cell proliferation and resistance to DNA-damaging treatment via maintaining cancer stemness.,2025,10.1016/j.jbc.2025.108170,https://pubmed.ncbi.nlm.nih.gov/39793896/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,41677721,Dual Effect of &lt;i&gt;EZH2&lt;/i&gt; Gene Editing with CRISPR/Cas9 in Lung Cancer.,2026,10.3390/biology15030251,https://pubmed.ncbi.nlm.nih.gov/41677721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,38984891,Tumor-Intrinsic Activity of Chromobox 2 Remodels the Tumor Microenvironment in High-grade Serous Carcinoma.,2024,10.1158/2767-9764.crc-24-0027,https://pubmed.ncbi.nlm.nih.gov/38984891/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,40846911,The role of collagen type VI alpha 6 chain as a potential tumor suppressor in breast cancer: an immune regulation perspective.,2025,10.1186/s12885-025-14680-1,https://pubmed.ncbi.nlm.nih.gov/40846911/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,37980163,Prognostic hub gene CBX2 drives a cancer stem cell-like phenotype in HCC revealed by multi-omics and multi-cohorts.,2023,10.18632/aging.205173,https://pubmed.ncbi.nlm.nih.gov/37980163/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,39223584,A novel super-enhancer-related risk model for predicting prognosis and guiding personalized treatment in hepatocellular carcinoma.,2024,10.1186/s12885-024-12874-7,https://pubmed.ncbi.nlm.nih.gov/39223584/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,37954123,miR‑149‑3p suppresses the proliferation and metastasis of glioma cells by targeting the CBX2/Wnt/β‑catenin pathway.,2023,10.3892/etm.2023.12261,https://pubmed.ncbi.nlm.nih.gov/37954123/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,38988558,Comprehensive molecular analyses and experimental validation of CDCAs with potential implications in kidney renal papillary cell carcinoma prognosis.,2024,10.1016/j.heliyon.2024.e33045,https://pubmed.ncbi.nlm.nih.gov/38988558/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,38030604,Phosphorylation of USP27X by GSK3β maintains the stability and oncogenic functions of CBX2.,2023,10.1038/s41419-023-06304-y,https://pubmed.ncbi.nlm.nih.gov/38030604/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,40725951,Deubiquitinase-associated mRNA signature model predicts prognosis and influences the immune microenvironment in patients with hepatocellular carcinoma: An observational study.,2025,10.1097/md.0000000000043442,https://pubmed.ncbi.nlm.nih.gov/40725951/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,38426219,How CBX proteins regulate normal and leukemic blood cells.,2024,10.1002/1873-3468.14839,https://pubmed.ncbi.nlm.nih.gov/38426219/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,38355480,Cuproptosis-related ceRNA axis triggers cell proliferation and cell cycle through CBX2 in lung adenocarcinoma.,2024,10.1186/s12890-024-02887-0,https://pubmed.ncbi.nlm.nih.gov/38355480/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,36155820,cbx2 is a functional target of the let-7 family in the gonad of Japanese flounder (Paralichthys olivaceus).,2023,10.1016/j.cbpb.2022.110799,https://pubmed.ncbi.nlm.nih.gov/36155820/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX2,ENSG00000173894,Unsafe,37430195,An integrative bioinformatics investigation and experimental validation of chromobox family in diffuse large B-cell lymphoma.,2023,10.1186/s12885-023-11108-6,https://pubmed.ncbi.nlm.nih.gov/37430195/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,42817804,METTL3 Increases Temozolomide Resistance in MGMT-Negative Glioblastoma by Enhancing CBX5 mRNA Stability in an m&lt;sup&gt;6&lt;/sup&gt;A-IGF2BP2-Dependent Manner.,2026,10.1002/cns.71164,https://pubmed.ncbi.nlm.nih.gov/42817804/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,42435771,Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression.,2026,10.1002/advs.76416,https://pubmed.ncbi.nlm.nih.gov/42435771/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,40940772,Ago2-Mediated Recruitment of HP1a on Transposable Elements in &lt;i&gt;Drosophila&lt;/i&gt; Brain.,2025,10.3390/cells14171361,https://pubmed.ncbi.nlm.nih.gov/40940772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,39642371,Targeting the Epigenetic Regulator CBX5 Promotes Fibroblast Metabolic Reprogramming and Inhibits Lung Fibrosis.,2025,10.1165/rcmb.2024-0255oc,https://pubmed.ncbi.nlm.nih.gov/39642371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,42458442,Trophoblast cells rewire the epigenetic landscape of vascular smooth muscle cells to modulate plasticity: a regulatory axis disrupted in intrauterine growth restriction.,2026,10.1186/s12964-026-03042-4,https://pubmed.ncbi.nlm.nih.gov/42458442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,41805129,In vitro reconstitution of heterochromatin compartments reveals the spontaneous formation of tunable liquid-liquid interfaces.,2026,10.1093/nar/gkag201,https://pubmed.ncbi.nlm.nih.gov/41805129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,42419880,Secondary peripheral T-cell lymphoma in a patient with DLBCL harboring &lt;i&gt;BLM&lt;/i&gt; mutation following CD19/CD22 bispecific CAR-T cell therapy.,2026,10.1136/jitc-2026-014873,https://pubmed.ncbi.nlm.nih.gov/42419880/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,39836054,The Sound of Silence: Suppressing CBX5 Decreases Fibrosis by Inhibiting Fibroblasts.,2025,10.1165/rcmb.2024-0618ed,https://pubmed.ncbi.nlm.nih.gov/39836054/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,41099702,Expanding the HP1a-binding consensus and molecular grammar for heterochromatin assembly.,2025,10.1093/nar/gkaf976,https://pubmed.ncbi.nlm.nih.gov/41099702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,39151099,Inhibition of RUNX1 slows the progression of pulmonary hypertension by targeting CBX5.,2025,10.17305/bb.2024.10720,https://pubmed.ncbi.nlm.nih.gov/39151099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,42204197,Prognostic significance of IDH1 promoter methylation and associated genome-wide alterations in breast cancer.,2026,10.1038/s41598-026-52790-3,https://pubmed.ncbi.nlm.nih.gov/42204197/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,40685483,Exploration of common pathogenic genes between cerebral amyloid angiopathy and insomnia based on bioinformatics and experimental validation.,2025,10.1038/s41598-025-12553-y,https://pubmed.ncbi.nlm.nih.gov/40685483/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,42106574,roX1 and roX2 lncRNAs promote heterochromatinization in intestinal stem cells and impair longevity.,2026,10.1038/s44319-026-00791-8,https://pubmed.ncbi.nlm.nih.gov/42106574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,41980468,Systematic Review: Porphyromonas gingivalis Outer Membrane Vesicles From Pathogenesis to Therapeutic Implications.,2026,10.1016/j.identj.2026.109548,https://pubmed.ncbi.nlm.nih.gov/41980468/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,41442547,Heterochromatin-based silencing of a foreign tandem repeat in Drosophila melanogaster shows unusual biochemistry and temperature sensitivity.,2026,10.1093/genetics/iyaf275,https://pubmed.ncbi.nlm.nih.gov/41442547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,40518278,"Long Noncoding RNA CCDC26 Interacts With Vimentin, HNRNPC, CBX1, and CBX5 Proteins in Multiple Intracellular Compartments of Myeloid Leukemia Cells.",2025,10.1111/gtc.70034,https://pubmed.ncbi.nlm.nih.gov/40518278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,39029934,Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis.,2024,10.26508/lsa.202402586,https://pubmed.ncbi.nlm.nih.gov/39029934/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,41091213,Phosphorylation as a regulatory mechanism of HP1 protein multifunctionality.,2025,10.1007/s00412-025-00838-0,https://pubmed.ncbi.nlm.nih.gov/41091213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,38831123,Inheritance of H3K9 methylation regulates genome architecture in Drosophila early embryos.,2024,10.1038/s44318-024-00127-z,https://pubmed.ncbi.nlm.nih.gov/38831123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,39261338,High sugar diet promotes tumor progression paradoxically through aberrant upregulation of pepck1.,2024,10.1007/s00018-024-05438-2,https://pubmed.ncbi.nlm.nih.gov/39261338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,38225273,"A CIC-related-epigenetic factors-based model associated with prediction, the tumor microenvironment and drug sensitivity in osteosarcoma.",2024,10.1038/s41598-023-49770-2,https://pubmed.ncbi.nlm.nih.gov/38225273/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,39216984,MED12 loss activates endogenous retroelements to sensitise immunotherapy in pancreatic cancer.,2024,10.1136/gutjnl-2024-332350,https://pubmed.ncbi.nlm.nih.gov/39216984/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,39657862,"Effective analysis of thyroid toxicity and mechanisms of acetyltributyl citrate using network toxicology, molecular docking, and machine learning strategies.",2025,10.1016/j.tox.2024.154029,https://pubmed.ncbi.nlm.nih.gov/39657862/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,39987187,Integrated bioinformatics investigation and experimental validation reveals the clinical and biological significance of chromobox family in breast cancer.,2025,10.1038/s41598-025-90771-0,https://pubmed.ncbi.nlm.nih.gov/39987187/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,37430195,An integrative bioinformatics investigation and experimental validation of chromobox family in diffuse large B-cell lymphoma.,2023,10.1186/s12885-023-11108-6,https://pubmed.ncbi.nlm.nih.gov/37430195/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,35282653,Diverse Chromobox Family Members: Potential Prognostic Biomarkers and Therapeutic Targets in Head and Neck Squamous Cell Carcinoma.,2022,10.2147/ijgm.s350783,https://pubmed.ncbi.nlm.nih.gov/35282653/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,34395271,Comprehensive Analysis of the Expression and Prognosis Value of Chromobox Family Members in Clear Cell Renal Cell Carcinoma.,2021,10.3389/fonc.2021.700528,https://pubmed.ncbi.nlm.nih.gov/34395271/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,36970607,Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis.,2023,10.3892/ol.2023.13758,https://pubmed.ncbi.nlm.nih.gov/36970607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,32585856,YBX1 Indirectly Targets Heterochromatin-Repressed Inflammatory Response-Related Apoptosis Genes through Regulating CBX5 mRNA.,2020,10.3390/ijms21124453,https://pubmed.ncbi.nlm.nih.gov/32585856/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,36140750,Expression and Prognostic Value of Chromobox Family Proteins in Esophageal Cancer.,2022,10.3390/genes13091582,https://pubmed.ncbi.nlm.nih.gov/36140750/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,37833877,Prolonged Inhibition of the MEK1/2-ERK Signaling Axis Primes Interleukin-1 Beta Expression through Histone 3 Lysine 9 Demethylation in Murine Macrophages.,2023,10.3390/ijms241914428,https://pubmed.ncbi.nlm.nih.gov/37833877/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,37860266,miR-3200 accelerates the growth of liver cancer cells by enhancing Rab7A.,2023,10.1016/j.ncrna.2023.10.005,https://pubmed.ncbi.nlm.nih.gov/37860266/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,34790394,Prognostic and immune infiltrates for the Chromobox (CBX) protein family in human pancreatic adenocarcinoma.,2021,10.21037/jgo-21-613,https://pubmed.ncbi.nlm.nih.gov/34790394/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBX5,ENSG00000094916,Unsafe,32860274,Mining database for the clinical significance and prognostic value of CBX family in skin cutaneous melanoma.,2020,10.1002/jcla.23537,https://pubmed.ncbi.nlm.nih.gov/32860274/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY3,ENSG00000204659,Unsafe,38197861,The Cby3/ciBAR1 complex positions the annulus along the sperm flagellum during spermiogenesis.,2024,10.1083/jcb.202307147,https://pubmed.ncbi.nlm.nih.gov/38197861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CBY3,ENSG00000204659,Unsafe,41693862,Metagenomic and metatranscriptomic profiling of bronchoalveolar lavage fluid identifies microbial and host biomarkers of drug-resistant tuberculosis.,2025,10.3389/fcimb.2025.1726935,https://pubmed.ncbi.nlm.nih.gov/41693862/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC110,ENSG00000168491,Unsafe,40394630,CCDC110 promotes the progression of hepatocellular carcinoma by activating the TGF-β/SMAD signaling pathway through targeted regulation of TGFBR1.,2025,10.1186/s12935-025-03803-0,https://pubmed.ncbi.nlm.nih.gov/40394630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC110,ENSG00000168491,Unsafe,32734127,Ectopic Overexpression of Coiled-Coil Domain Containing 110 Delays G2/M Entry in U2-OS Cells.,2020,10.12717/dr.2020.24.2.101,https://pubmed.ncbi.nlm.nih.gov/32734127/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC110,ENSG00000168491,Unsafe,39736507,Genome-wide analysis in northern Chinese twins identifies twelve new susceptibility loci for pulmonary function.,2024,10.1186/s12864-024-11165-6,https://pubmed.ncbi.nlm.nih.gov/39736507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC110,ENSG00000168491,Unsafe,32075680,Maternal diabetes and obesity influence the fetal epigenome in a largely Hispanic population.,2020,10.1186/s13148-020-0824-9,https://pubmed.ncbi.nlm.nih.gov/32075680/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC110,ENSG00000168491,Unsafe,24228692,Analysis of Sry duplications on the Rattus norvegicus Y-chromosome.,2013,10.1186/1471-2164-14-792,https://pubmed.ncbi.nlm.nih.gov/24228692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC110,ENSG00000168491,Unsafe,15447989,"Identification of a novel human cancer/testis antigen, KM-HN-1, recognized by cellular and humoral immune responses.",2004,10.1158/1078-0432.ccr-04-0475,https://pubmed.ncbi.nlm.nih.gov/15447989/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC122,ENSG00000151773,Unsafe,41917816,Expression and regulation of lncRNAs in the testes of Yili geese with high and low sperm motility.,2026,10.1186/s12864-026-12731-w,https://pubmed.ncbi.nlm.nih.gov/41917816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC122,ENSG00000151773,Unsafe,41053005,Integrating genetic regulation and schizophrenia-specific splicing quantitative expression with GWAS prioritizes novel risk genes for schizophrenia.,2025,10.1038/s41398-025-03633-8,https://pubmed.ncbi.nlm.nih.gov/41053005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC122,ENSG00000151773,Unsafe,41430577,CCDC122-LACC1 gene polymorphism is associated with protection against leprosy in a population from Northeastern Brazil: a case-control study.,2025,10.1186/s12879-025-12391-3,https://pubmed.ncbi.nlm.nih.gov/41430577/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC122,ENSG00000151773,Unsafe,40265030,5hmC-profiles in Puerto Rican Hispanic/Latino men with aggressive prostate cancer.,2025,10.3389/fonc.2025.1541878,https://pubmed.ncbi.nlm.nih.gov/40265030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC122,ENSG00000151773,Unsafe,26235265,"Association between genetic variants in NOD2, C13orf31, and CCDC122 genes and leprosy among the Chinese Yi population.",2016,10.1111/ijd.12981,https://pubmed.ncbi.nlm.nih.gov/26235265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC122,ENSG00000151773,Unsafe,32433683,Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population.,2020,10.1371/journal.pntd.0008247,https://pubmed.ncbi.nlm.nih.gov/32433683/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC122,ENSG00000151773,Unsafe,22984114,Crohn's disease susceptibility genes are associated with leprosy in the Vietnamese population.,2012,10.1093/infdis/jis588,https://pubmed.ncbi.nlm.nih.gov/22984114/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC122,ENSG00000151773,Unsafe,21585556,Gene expression analysis of leprosy by using a multiplex branched DNA assay.,2011,10.1111/j.1600-0625.2011.01270.x,https://pubmed.ncbi.nlm.nih.gov/21585556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC136,ENSG00000128596,Unsafe,40276155,Proteomic analysis of Toraya buffalo seminal plasma and sperm: uncovering insights to optimize reproductive success.,2025,10.3389/fvets.2025.1492135,https://pubmed.ncbi.nlm.nih.gov/40276155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC136,ENSG00000128596,Unsafe,41806660,Proteomic insights into the effects of cryopreservation on sperm of endangered Eld's deer (Rucervus eldii).,2026,10.1016/j.repbio.2026.101200,https://pubmed.ncbi.nlm.nih.gov/41806660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC136,ENSG00000128596,Unsafe,37496441,PVT1 interacts with polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma.,2024,10.3324/haematol.2023.282965,https://pubmed.ncbi.nlm.nih.gov/37496441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC136,ENSG00000128596,Unsafe,34539327,Identification of Phonology-Related Genes and Functional Characterization of Broca's and Wernicke's Regions in Language and Learning Disorders.,2021,10.3389/fnins.2021.680762,https://pubmed.ncbi.nlm.nih.gov/34539327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC136,ENSG00000128596,Unsafe,27076447,"A Novel Testis-Specific Gene, Ccdc136, Is Required for Acrosome Formation and Fertilization in Mice.",2016,10.1177/1933719116641762,https://pubmed.ncbi.nlm.nih.gov/27076447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC136,ENSG00000128596,Unsafe,28866788,Enrichment of putatively damaging rare variants in the DYX2 locus and the reading-related genes CCDC136 and FLNC.,2017,10.1007/s00439-017-1838-z,https://pubmed.ncbi.nlm.nih.gov/28866788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC136,ENSG00000128596,Unsafe,34519615,Transcriptome-based identification of molecular markers related to the development and prognosis of Colon cancer.,2021,10.1080/15257770.2021.1975298,https://pubmed.ncbi.nlm.nih.gov/34519615/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC136,ENSG00000128596,Unsafe,26965927,Establishment of a cone photoreceptor transplantation platform based on a novel cone-GFP reporter mouse line.,2016,10.1038/srep22867,https://pubmed.ncbi.nlm.nih.gov/26965927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC136,ENSG00000128596,Unsafe,27476042,Neuroimaging genetic analyses of novel candidate genes associated with reading and language.,2017,10.1016/j.bandl.2016.07.002,https://pubmed.ncbi.nlm.nih.gov/27476042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC136,ENSG00000128596,Unsafe,30833875,Analysis of mRNA Expression Patterns in Peripheral Blood Cells of 3 Patients With Cancer After the First Fraction of 2 Gy Irradiation: An Integrated Case Report and Systematic Review.,2019,10.1177/1559325819833474,https://pubmed.ncbi.nlm.nih.gov/30833875/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC136,ENSG00000128596,Unsafe,27477027,The coiled-coil domain containing protein Ccdc136b antagonizes maternal Wnt/β-catenin activity during zebrafish dorsoventral axial patterning.,2016,10.1016/j.jgg.2016.05.003,https://pubmed.ncbi.nlm.nih.gov/27477027/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC136,ENSG00000128596,Unsafe,25065397,Genome-wide screening for DNA variants associated with reading and language traits.,2014,10.1111/gbb.12158,https://pubmed.ncbi.nlm.nih.gov/25065397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC136,ENSG00000128596,Unsafe,15112360,Expression of tumor related gene NAG6 in gastric cancer and restriction fragment length polymorphism analysis.,2004,10.3748/wjg.v10.i9.1361,https://pubmed.ncbi.nlm.nih.gov/15112360/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC138,ENSG00000163006,Unsafe,40861419,CCDC138 overexpression predicts poor prognosis and highlights ciliopathy-linked mechanisms in uterine corpus endometrial carcinoma.,2025,10.3389/fmolb.2025.1622496,https://pubmed.ncbi.nlm.nih.gov/40861419/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC138,ENSG00000163006,Unsafe,38439961,Multiomics profiling of urothelial carcinoma &lt;i&gt;in situ&lt;/i&gt; reveals CIS-specific gene signature and immune characteristics.,2024,10.1016/j.isci.2024.109179,https://pubmed.ncbi.nlm.nih.gov/38439961/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC138,ENSG00000163006,Unsafe,28596423,"Integration of over 9,000 mass spectrometry experiments builds a global map of human protein complexes.",2017,10.15252/msb.20167490,https://pubmed.ncbi.nlm.nih.gov/28596423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC148,ENSG00000153237,Unsafe,39165107,A polarized multicomponent foundation upholds ciliary central microtubules.,2025,10.1093/jmcb/mjae031,https://pubmed.ncbi.nlm.nih.gov/39165107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC148,ENSG00000153237,Unsafe,39943913,Urine exosomal lncRNAs as novel biomarkers for early diagnosis of bladder cancer based on microarray differential expression profiling.,2025,10.1177/03936155251317551,https://pubmed.ncbi.nlm.nih.gov/39943913/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC148,ENSG00000153237,Unsafe,35776183,Genome-wide association study of aromatase inhibitor discontinuation due to musculoskeletal symptoms.,2022,10.1007/s00520-022-07243-8,https://pubmed.ncbi.nlm.nih.gov/35776183/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC148,ENSG00000153237,Unsafe,31860576,Identification of Specific Tumor Markers in Vulvar Carcinoma Through Extensive Human Papillomavirus DNA Characterization Using Next Generation Sequencing Method.,2020,10.1097/lgt.0000000000000498,https://pubmed.ncbi.nlm.nih.gov/31860576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC148,ENSG00000153237,Unsafe,30598658,The plasma peptides of ovarian cancer.,2018,10.1186/s12014-018-9215-z,https://pubmed.ncbi.nlm.nih.gov/30598658/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC148,ENSG00000153237,Unsafe,21297076,"Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1.",2011,10.1164/rccm.201006-0912oc,https://pubmed.ncbi.nlm.nih.gov/21297076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC15,ENSG00000149548,Unsafe,37934472,CCDC15 localizes to the centriole inner scaffold and controls centriole length and integrity.,2023,10.1083/jcb.202305009,https://pubmed.ncbi.nlm.nih.gov/37934472/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC15,ENSG00000149548,Unsafe,39066603,Single-cell RNA sequencing of peripheral blood mononuclear cells from pregnant women with Systemic lupus erythematosus.,2024,10.1080/08830185.2024.2376649,https://pubmed.ncbi.nlm.nih.gov/39066603/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC15,ENSG00000149548,Unsafe,33362856,"Bioinformatics Analysis Reveals an Association Between Cancer Cell Stemness, Gene Mutations, and the Immune Microenvironment in Stomach Adenocarcinoma.",2020,10.3389/fgene.2020.595477,https://pubmed.ncbi.nlm.nih.gov/33362856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC150,ENSG00000144395,Unsafe,38420580,Gradient Rotating Magnetic Fields Impairing F-Actin-Related Gene CCDC150 to Inhibit Triple-Negative Breast Cancer Metastasis by Inactivating TGF-β1/SMAD3 Signaling Pathway.,2024,10.34133/research.0320,https://pubmed.ncbi.nlm.nih.gov/38420580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC150,ENSG00000144395,Unsafe,36910711,Enzalutamide-induced signatures revealed by epigenetic plasticity using single-cell multi-omics sequencing in prostate cancer.,2023,10.1016/j.omtn.2023.02.022,https://pubmed.ncbi.nlm.nih.gov/36910711/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC150,ENSG00000144395,Unsafe,36601001,CCNB1 and AURKA are critical genes for prostate cancer progression and castration-resistant prostate cancer resistant to vinblastine.,2022,10.3389/fendo.2022.1106175,https://pubmed.ncbi.nlm.nih.gov/36601001/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC150,ENSG00000144395,Unsafe,36099812,Genetic landscape of a large cohort of Primary Ovarian Insufficiency: New genes and pathways and implications for personalized medicine.,2022,10.1016/j.ebiom.2022.104246,https://pubmed.ncbi.nlm.nih.gov/36099812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC152,ENSG00000198865,Unsafe,42874130,LncRNA CCDC152 coordinates a tumor-associated selenoprotein P cycle that sustains selenium-dependent redox homeostasis in glioblastoma.,2026,10.1016/j.redox.2026.104438,https://pubmed.ncbi.nlm.nih.gov/42874130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC152,ENSG00000198865,Unsafe,39462603,"Ccdc152 is not necessary for male fertility, but contributes to maintaining sperm morphology.",2024,10.1262/jrd.2024-058,https://pubmed.ncbi.nlm.nih.gov/39462603/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC152,ENSG00000198865,Unsafe,34142161,Identification of a novel endogenous long non-coding RNA that inhibits selenoprotein P translation.,2021,10.1093/nar/gkab498,https://pubmed.ncbi.nlm.nih.gov/34142161/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC152,ENSG00000198865,Unsafe,29137403,Chicken CCDC152 shares an NFYB-regulated bidirectional promoter with a growth hormone receptor antisense transcript and inhibits cells proliferation and migration.,2017,10.18632/oncotarget.21091,https://pubmed.ncbi.nlm.nih.gov/29137403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC152,ENSG00000198865,Unsafe,35378223,Transcriptome analysis of colorectal cancer liver metastasis: The importance of long non-coding RNAs and fusion transcripts in the disease pathogenesis.,2022,10.1016/j.mcp.2022.101816,https://pubmed.ncbi.nlm.nih.gov/35378223/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC152,ENSG00000198865,Unsafe,33563042,Identification of 6 gene markers for survival prediction in osteosarcoma cases based on multi-omics analysis.,2021,10.1177/1535370221992015,https://pubmed.ncbi.nlm.nih.gov/33563042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC152,ENSG00000198865,Unsafe,31806577,Transcriptional analyses of endometrial caruncles in sheep with in vivo / in vitro produced embryos during the peri-implantation period.,2019,10.1016/j.repbio.2019.09.008,https://pubmed.ncbi.nlm.nih.gov/31806577/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC152,ENSG00000198865,Unsafe,34306039,Genome-Wide Scanning for Signatures of Selection Revealed the Putative Genomic Regions and Candidate Genes Controlling Milk Composition and Coat Color Traits in Sahiwal Cattle.,2021,10.3389/fgene.2021.699422,https://pubmed.ncbi.nlm.nih.gov/34306039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC152,ENSG00000198865,Unsafe,15809229,Comparative gene finding in chicken indicates that we are closing in on the set of multi-exonic widely expressed human genes.,2005,10.1093/nar/gki328,https://pubmed.ncbi.nlm.nih.gov/15809229/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC157,ENSG00000187860,Unsafe,38509755,CCDC157 is essential for sperm differentiation and shows oligoasthenoteratozoospermia-related mutations in men.,2024,10.1111/jcmm.18215,https://pubmed.ncbi.nlm.nih.gov/38509755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC157,ENSG00000187860,Unsafe,41076474,Deleterious variants in LTBP4 are associated with severe pediatric sepsis.,2026,10.1038/s41390-025-04420-3,https://pubmed.ncbi.nlm.nih.gov/41076474/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC157,ENSG00000187860,Unsafe,39276353,Integrative identification of non-coding regulatory regions driving metastatic prostate cancer.,2024,10.1016/j.celrep.2024.114764,https://pubmed.ncbi.nlm.nih.gov/39276353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC157,ENSG00000187860,Unsafe,41139140,Evaluation of genetic diversity and selection signals in gayal populations across four countries through whole-genome resequencing.,2025,10.1007/s44154-025-00252-7,https://pubmed.ncbi.nlm.nih.gov/41139140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC157,ENSG00000187860,Unsafe,30741974,"Drosophila Pif1A is essential for spermatogenesis and is the homolog of human CCDC157, a gene associated with idiopathic NOA.",2019,10.1038/s41419-019-1398-3,https://pubmed.ncbi.nlm.nih.gov/30741974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC157,ENSG00000187860,Unsafe,31488582,New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells.,2019,10.1083/jcb.201902028,https://pubmed.ncbi.nlm.nih.gov/31488582/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC157,ENSG00000187860,Unsafe,30456215,Transcriptional Profiling of Hypoxia-Regulated Non-coding RNAs in Human Primary Endothelial Cells.,2018,10.3389/fcvm.2018.00159,https://pubmed.ncbi.nlm.nih.gov/30456215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC157,ENSG00000187860,Unsafe,35945964,Genome-Wide Association Study on the Hematological Phenotypic Characteristics of the Han Population from Northwest China.,2022,10.2147/pgpm.s361809,https://pubmed.ncbi.nlm.nih.gov/35945964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC169,ENSG00000242715,Unsafe,35052827,Identification of Thrombosis-Related Genes in Patients with Advanced Gastric Cancer: Data from AGAMENON-SEOM Registry.,2022,10.3390/biomedicines10010148,https://pubmed.ncbi.nlm.nih.gov/35052827/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC169,ENSG00000242715,Unsafe,35187167,Identification of a Five-Gene Panel to Assess Prognosis for Gastric Cancer.,2022,10.1155/2022/5593619,https://pubmed.ncbi.nlm.nih.gov/35187167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC169,ENSG00000242715,Unsafe,32462188,Flexible Mixture Model Approaches That Accommodate Footprint Size Variability for Robust Detection of Balancing Selection.,2020,10.1093/molbev/msaa134,https://pubmed.ncbi.nlm.nih.gov/32462188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC169,ENSG00000242715,Unsafe,31174021,Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells.,2019,10.1016/j.neo.2019.04.009,https://pubmed.ncbi.nlm.nih.gov/31174021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,42777143,"Breast Cancer-Protective Genetic Variant Common in Women of Indigenous American Genetic Ancestry Is a cis-eQTL for RMND1, ARMT1, and CCDC170 in HER2-Enriched Tumor Subtypes.",2026,10.1158/2767-9764.crc-26-0293,https://pubmed.ncbi.nlm.nih.gov/42777143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,39206151,"The expression of lnc-CCDC170-4:1, ESR1, lncRNA SRA, and CYP19A1 in cervical squamous cell carcinoma and their relationship with the clinical characteristics.",2024,10.3389/fonc.2024.1430826,https://pubmed.ncbi.nlm.nih.gov/39206151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,42135449,ESR1 fusion proteins in breast cancer: distinguishing oncogenic drivers from passenger events.,2026,10.1038/s41388-026-03813-w,https://pubmed.ncbi.nlm.nih.gov/42135449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,38956598,Impact of aquaporin-4 and CD11c + microglia in the development of ependymal cells in the aqueduct: inferences to hydrocephalus.,2024,10.1186/s12987-024-00548-2,https://pubmed.ncbi.nlm.nih.gov/38956598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,41555446,Characterization of ESR1 alterations in patients with breast and gynecologic cancers.,2026,10.1186/s13058-025-02217-0,https://pubmed.ncbi.nlm.nih.gov/41555446/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,37024829,Whole-exome mutational landscape and molecular marker study in mucinous and clear cell ovarian cancer cell lines 3AO and ES2.,2023,10.1186/s12885-023-10791-9,https://pubmed.ncbi.nlm.nih.gov/37024829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,37774059,Potential Candidate Genes for Therapeutic Targeting in Chronic Myeloid Leukemia: A Pilot Study.,2023,10.31557/apjcp.2023.24.9.3077,https://pubmed.ncbi.nlm.nih.gov/37774059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,38153509,The osteoporosis susceptibility SNP rs188303909 at 2q14.2 regulates EN1 expression by modulating DNA methylation and E2F6 binding.,2024,10.1007/s00109-023-02412-6,https://pubmed.ncbi.nlm.nih.gov/38153509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,36543131,A molecular atlas of the human postmenopausal fallopian tube and ovary from single-cell RNA and ATAC sequencing.,2022,10.1016/j.celrep.2022.111838,https://pubmed.ncbi.nlm.nih.gov/36543131/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,39319846,&lt;i&gt;F13B&lt;/i&gt; regulates angiogenesis and tumor progression in hepatocellular carcinoma via the HIF-1α/VEGF pathway.,2024,10.17305/bb.2024.10794,https://pubmed.ncbi.nlm.nih.gov/39319846/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,40750431,"Comparison of Comprehensive Genomic Profiling Testing ""Ion Torrent Genexus Sequencer"" With FoundationOne.",2025,10.21873/anticanres.17709,https://pubmed.ncbi.nlm.nih.gov/40750431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,35151276,The prognostic and predictive value of ESR1 fusion gene transcripts in primary breast cancer.,2022,10.1186/s12885-022-09265-1,https://pubmed.ncbi.nlm.nih.gov/35151276/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,40609267,B lymphocytes impair osteogenesis by inhibiting BMSC differentiation in osteoporosis.,2025,10.1016/j.imbio.2025.153094,https://pubmed.ncbi.nlm.nih.gov/40609267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,40369610,ESR1 testing on FFPE samples from metastatic lesions in HR + /HER2- breast cancer after progression on CDK4/6 inhibitor therapy.,2025,10.1186/s13058-025-02020-x,https://pubmed.ncbi.nlm.nih.gov/40369610/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,38160230,Rapid detection of mutations in CSF-cfTNA with the Genexus Integrated Sequencer.,2024,10.1007/s11060-023-04487-0,https://pubmed.ncbi.nlm.nih.gov/38160230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,35263124,A single locus regulates a female-limited color pattern polymorphism in a reptile.,2022,10.1126/sciadv.abm2387,https://pubmed.ncbi.nlm.nih.gov/35263124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,33291081,CCDC170 affects breast cancer apoptosis through IRE1 pathway.,2020,10.18632/aging.202315,https://pubmed.ncbi.nlm.nih.gov/33291081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,33785515,Three functional polymorphisms in CCDC170 were associated with osteoporosis phenotype.,2021,10.1242/bio.050930,https://pubmed.ncbi.nlm.nih.gov/33785515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,28687497,The Protein Encoded by the CCDC170 Breast Cancer Gene Functions to Organize the Golgi-Microtubule Network.,2017,10.1016/j.ebiom.2017.06.024,https://pubmed.ncbi.nlm.nih.gov/28687497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,38982179,Ethnic-specific genetic susceptibility loci for endometriosis in Taiwanese-Han population: a genome-wide association study.,2024,10.1038/s10038-024-01270-5,https://pubmed.ncbi.nlm.nih.gov/38982179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,32771039,Therapeutic role of recurrent ESR1-CCDC170 gene fusions in breast cancer endocrine resistance.,2020,10.1186/s13058-020-01325-3,https://pubmed.ncbi.nlm.nih.gov/32771039/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,35106856,"Fusion-associated carcinomas of the breast: Diagnostic, prognostic, and therapeutic significance.",2022,10.1002/gcc.23029,https://pubmed.ncbi.nlm.nih.gov/35106856/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,32321829,Landscape analysis of adjacent gene rearrangements reveals BCL2L14-ETV6 gene fusions in more aggressive triple-negative breast cancer.,2020,10.1073/pnas.1921333117,https://pubmed.ncbi.nlm.nih.gov/32321829/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,30382883,Landscape of genomic alterations in high-grade serous ovarian cancer from exceptional long- and short-term survivors.,2018,10.1186/s13073-018-0590-x,https://pubmed.ncbi.nlm.nih.gov/30382883/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,33249669,A Meta-Analysis of the Transferability of Bone Mineral Density Genetic Loci Associations From European to African Ancestry Populations.,2021,10.1002/jbmr.4220,https://pubmed.ncbi.nlm.nih.gov/33249669/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,27372070,Recurrent and pathological gene fusions in breast cancer: current advances in genomic discovery and clinical implications.,2016,10.1007/s10549-016-3876-y,https://pubmed.ncbi.nlm.nih.gov/27372070/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC170,ENSG00000120262,Unsafe,21552322,ESR1 is co-expressed with closely adjacent uncharacterised genes spanning a breast cancer susceptibility locus at 6q25.1.,2011,10.1371/journal.pgen.1001382,https://pubmed.ncbi.nlm.nih.gov/21552322/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC171,ENSG00000164989,Unsafe,40961765,Integrative multi-omics analysis deciphers the regulatory mechanisms of egg weight traits in chickens.,2025,10.1016/j.psj.2025.105813,https://pubmed.ncbi.nlm.nih.gov/40961765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC171,ENSG00000164989,Unsafe,32046176,Proteomic Analysis of Human Serum from Patients with Chronic Kidney Disease.,2020,10.3390/biom10020257,https://pubmed.ncbi.nlm.nih.gov/32046176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC171,ENSG00000164989,Unsafe,31745258,Identification and functional validation of genetic variants in potential miRNA target sites of established BMI genes.,2020,10.1038/s41366-019-0488-8,https://pubmed.ncbi.nlm.nih.gov/31745258/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC171,ENSG00000164989,Unsafe,29477148,Gene-diet interaction effects on BMI levels in the Singapore Chinese population.,2018,10.1186/s12937-018-0340-3,https://pubmed.ncbi.nlm.nih.gov/29477148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC171,ENSG00000164989,Unsafe,26840454,Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.,2016,10.18632/oncotarget.7047,https://pubmed.ncbi.nlm.nih.gov/26840454/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC172,ENSG00000182645,Unsafe,24394471,Molecular cloning and subcellular localization of Tektin2-binding protein 1 (Ccdc 172) in rat spermatozoa.,2014,10.1369/0022155413520607,https://pubmed.ncbi.nlm.nih.gov/24394471/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC18,ENSG00000122483,Unsafe,41664933,Prognostic value of CCDC18-AS1 in gastric cancer and its regulatory effect on tumor progression.,2026,10.1080/17520363.2026.2626438,https://pubmed.ncbi.nlm.nih.gov/41664933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC18,ENSG00000122483,Unsafe,41152415,Berberine alleviates the proliferation and metastasis of ESCA by promoting CCDC18-AS1 expression based on bioinformatics and in vitro experimental verification.,2025,10.1038/s41598-025-21581-7,https://pubmed.ncbi.nlm.nih.gov/41152415/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC18,ENSG00000122483,Unsafe,39798887,Identification of aberrant plasma vesicles containing AAK1 and CCDC18-AS1 in adolescents with major depressive disorder and preliminary exploration of treatment efficacy.,2025,10.1016/j.ygeno.2025.110993,https://pubmed.ncbi.nlm.nih.gov/39798887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC18,ENSG00000122483,Unsafe,38474122,Comprehensive Atlas of Alternative Splicing Reveals NSRP1 Promoting Adipogenesis through CCDC18.,2024,10.3390/ijms25052874,https://pubmed.ncbi.nlm.nih.gov/38474122/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC18,ENSG00000122483,Unsafe,36160032,"Quantitative Expression of SFN, lncRNA CCDC18-AS1, and lncRNA LINC01343 in Human Breast Cancer as the Regulator Biomarkers in a Novel ceRNA Network: Based on Bioinformatics and Experimental Analyses.",2022,10.1155/2022/6787791,https://pubmed.ncbi.nlm.nih.gov/36160032/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC18,ENSG00000122483,Unsafe,38123886,Identification of key gene expression associated with quality of life after recovery from COVID-19.,2024,10.1007/s11517-023-02988-8,https://pubmed.ncbi.nlm.nih.gov/38123886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC18,ENSG00000122483,Unsafe,36619896,Analysis of Long Noncoding RNAs-Related Regulatory Mechanisms in Duchenne Muscular Dystrophy Using a Disease-Related lncRNA-mRNA Pathway Network.,2022,10.1155/2022/8548804,https://pubmed.ncbi.nlm.nih.gov/36619896/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC18,ENSG00000122483,Unsafe,37848987,Upregulation of BMP1 through ncRNAs correlates with adverse outcomes and immune infiltration in clear cell renal cell carcinoma.,2023,10.1186/s40001-023-01422-x,https://pubmed.ncbi.nlm.nih.gov/37848987/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC18,ENSG00000122483,Unsafe,37626362,Analysis on EZH2: mechanism identification of related CeRNA and its immunoassay in hepatocellular carcinoma.,2023,10.1186/s12920-023-01594-9,https://pubmed.ncbi.nlm.nih.gov/37626362/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC18,ENSG00000122483,Unsafe,34912698,RAB42 Promotes Glioma Pathogenesis via the VEGF Signaling Pathway.,2021,10.3389/fonc.2021.657029,https://pubmed.ncbi.nlm.nih.gov/34912698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC18,ENSG00000122483,Unsafe,36910711,Enzalutamide-induced signatures revealed by epigenetic plasticity using single-cell multi-omics sequencing in prostate cancer.,2023,10.1016/j.omtn.2023.02.022,https://pubmed.ncbi.nlm.nih.gov/36910711/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC18,ENSG00000122483,Unsafe,33732554,Integrated analysis of immune-related long noncoding RNAs as diagnostic biomarkers in psoriasis.,2021,10.7717/peerj.11018,https://pubmed.ncbi.nlm.nih.gov/33732554/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC18,ENSG00000122483,Unsafe,36270987,Antisense lncRNA NNT-AS1 promoted esophageal squamous cell carcinoma progression by regulating its sense gene NNT expression.,2022,10.1038/s41420-022-01216-w,https://pubmed.ncbi.nlm.nih.gov/36270987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC18,ENSG00000122483,Unsafe,37227248,Identification and validation of a cellular senescence-related lncRNA signature for prognostic prediction in patients with multiple myeloma.,2023,10.1080/15384101.2023.2213926,https://pubmed.ncbi.nlm.nih.gov/37227248/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC18,ENSG00000122483,Unsafe,34966747,A Prognostic Pyroptosis-Related lncRNAs Risk Model Correlates With the Immune Microenvironment in Colon Adenocarcinoma.,2021,10.3389/fcell.2021.811734,https://pubmed.ncbi.nlm.nih.gov/34966747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC18,ENSG00000122483,Unsafe,24146633,Eleven candidate susceptibility genes for common familial colorectal cancer.,2013,10.1371/journal.pgen.1003876,https://pubmed.ncbi.nlm.nih.gov/24146633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,42288241,"CCDC181, a kinocilium-localization protein, is dispensable for hair bundle development and auditory perception.",2026,10.1016/j.neulet.2026.138660,https://pubmed.ncbi.nlm.nih.gov/42288241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,39245650,CCDC181 is required for sperm flagellum biogenesis and male fertility in mice.,2024,10.24272/j.issn.2095-8137.2024.075,https://pubmed.ncbi.nlm.nih.gov/39245650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,42511847,Genome-Wide Association and Meta-Analysis Identify Candidate Genes for Sperm Freezability in Duroc and Yorkshire Boars.,2026,10.3390/ijms27146506,https://pubmed.ncbi.nlm.nih.gov/42511847/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,39019207,CCDC181 is required for proper spermiogenesis in mice.,2024,10.1016/j.jgg.2024.07.010,https://pubmed.ncbi.nlm.nih.gov/39019207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,41909960,Genetic Parameters and Genome-Wide Association Studies for Fertility and Reproduction Traits in U.S. Katahdin Sheep Based on the Single-Step GBLUP Methodology.,2026,10.1111/jbg.70048,https://pubmed.ncbi.nlm.nih.gov/41909960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,33803633,"Automatic Detection of the Circulating Cell-Free Methylated DNA Pattern of GCM2, ITPRIPL1 and CCDC181 for Detection of Early Breast Cancer and Surgical Treatment Response.",2021,10.3390/cancers13061375,https://pubmed.ncbi.nlm.nih.gov/33803633/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,38830954,Compound heterozygous mutations in a mouse model of Leber congenital amaurosis reveal the role of CCT2 in photoreceptor maintenance.,2024,10.1038/s42003-024-06384-2,https://pubmed.ncbi.nlm.nih.gov/38830954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,38892912,An Exercise Immune Fitness Test to Unravel Disease Mechanisms-A Proof-of-Concept Heart Failure Study.,2024,10.3390/jcm13113200,https://pubmed.ncbi.nlm.nih.gov/38892912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,37628841,Methylation Profile of Small Breast Cancer Tumors Evaluated by Modified MS-HRM.,2023,10.3390/ijms241612660,https://pubmed.ncbi.nlm.nih.gov/37628841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,28283191,Ccdc181 is a microtubule-binding protein that interacts with Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia.,2017,10.1016/j.ejcb.2017.02.003,https://pubmed.ncbi.nlm.nih.gov/28283191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,34116718,Screening and identification of Theileria annulata subtelomere-encoded variable secreted protein-950454 (SVSP454) interacting proteins from bovine B cells.,2021,10.1186/s13071-021-04820-4,https://pubmed.ncbi.nlm.nih.gov/34116718/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,34198725,"Promoter Methylation of PRKCB, ADAMTS12, and NAALAD2 Is Specific to Prostate Cancer and Predicts Biochemical Disease Recurrence.",2021,10.3390/ijms22116091,https://pubmed.ncbi.nlm.nih.gov/34198725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,34737001,Genome-wide analysis of methylation CpG sites in gene promoters identified four pairs of CpGs-mRNAs associated with lung adenocarcinoma prognosis.,2022,10.1016/j.gene.2021.146054,https://pubmed.ncbi.nlm.nih.gov/34737001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,25238417,Prognostic DNA methylation markers for prostate cancer.,2014,10.3390/ijms150916544,https://pubmed.ncbi.nlm.nih.gov/25238417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,28084441,Heterogeneous patterns of DNA methylation-based field effects in histologically normal prostate tissue from cancer patients.,2017,10.1038/srep40636,https://pubmed.ncbi.nlm.nih.gov/28084441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,29465788,Biomarker potential of ST6GALNAC3 and ZNF660 promoter hypermethylation in prostate cancer tissue and liquid biopsies.,2018,10.1002/1878-0261.12183,https://pubmed.ncbi.nlm.nih.gov/29465788/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,32991011,Diagnosis and prognosis potential of four gene promoter hypermethylation in prostate cancer.,2021,10.1002/cbin.11474,https://pubmed.ncbi.nlm.nih.gov/32991011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,35015293,Histone Methylation Regulates Gene Expression in the Round Spermatids to Set the RNA Payloads of Sperm.,2022,10.1007/s43032-021-00837-3,https://pubmed.ncbi.nlm.nih.gov/35015293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,30498398,Exploration of methylation-driven genes for monitoring and prognosis of patients with lung adenocarcinoma.,2018,10.1186/s12935-018-0691-z,https://pubmed.ncbi.nlm.nih.gov/30498398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,28282151,Quantitative Proteomic Analysis of Human Airway Cilia Identifies Previously Uncharacterized Proteins of High Abundance.,2017,10.1021/acs.jproteome.6b00972,https://pubmed.ncbi.nlm.nih.gov/28282151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC181,ENSG00000117477,Unsafe,30218172,DNA methylation marker to estimate the breast cancer cell fraction in DNA samples.,2018,10.1007/s12032-018-1207-3,https://pubmed.ncbi.nlm.nih.gov/30218172/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC188,ENSG00000234409,Unsafe,39292630,Loss of CCDC188 causes male infertility with defects in the sperm head-neck connection in mice†.,2025,10.1093/biolre/ioae137,https://pubmed.ncbi.nlm.nih.gov/39292630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC188,ENSG00000234409,Unsafe,38616611,Discovery of CCDC188 gene as a novel genetic target for human acephalic spermatozoa syndrome.,2024,10.1093/procel/pwae018,https://pubmed.ncbi.nlm.nih.gov/38616611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC188,ENSG00000234409,Unsafe,32454406,Comparative exome sequencing reveals novel candidate genes for retinitis pigmentosa.,2020,10.1016/j.ebiom.2020.102792,https://pubmed.ncbi.nlm.nih.gov/32454406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC196,ENSG00000196553,Unsafe,41765993,Transcriptional adaptation of rumen papillae to high-grain diet reveals distinct temporal phases and SARA susceptibility signatures.,2026,10.1186/s40104-026-01352-8,https://pubmed.ncbi.nlm.nih.gov/41765993/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC196,ENSG00000196553,Unsafe,35014686,Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522.,2022,10.3892/mmr.2022.12587,https://pubmed.ncbi.nlm.nih.gov/35014686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC196,ENSG00000196553,Unsafe,34476506,LINC00238 inhibits hepatic carcinoma progression by activating TMEM106C‑mediated apoptosis pathway.,2021,10.3892/mmr.2021.12397,https://pubmed.ncbi.nlm.nih.gov/34476506/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC196,ENSG00000196553,Unsafe,39316935,Divergent transcriptomic profiles in depressed individuals with hyper- and hypophagia implicating inflammatory status.,2024,10.1016/j.jpsychires.2024.09.020,https://pubmed.ncbi.nlm.nih.gov/39316935/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC196,ENSG00000196553,Unsafe,38426568,[Corrigendum] Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522.,2024,10.3892/mmr.2024.13189,https://pubmed.ncbi.nlm.nih.gov/38426568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC196,ENSG00000196553,Unsafe,38844868,Using expression data to fine map QTL associated with fertility in dairy cattle.,2024,10.1186/s12711-024-00912-8,https://pubmed.ncbi.nlm.nih.gov/38844868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,42908110,PCGF1 Promotes the Tumorigenesis of Malignancies Through Upregulating CCDC34 in Glioma.,2026,10.1002/acn3.70559,https://pubmed.ncbi.nlm.nih.gov/42908110/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,42065799,TCF12-mediated transcriptional activation of CCDC34 is involved in the positive feedback of tumor-associated macrophages and EMT to promote LUSC.,2026,10.1007/s10565-026-10200-4,https://pubmed.ncbi.nlm.nih.gov/42065799/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,40522566,The oncogenic role of CCDC34 in lower-grade gliomas: prognostic significance and therapeutic potential.,2025,10.1007/s11060-025-05090-1,https://pubmed.ncbi.nlm.nih.gov/40522566/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,39587349,CCDC34 maintains stemness phenotype through β-catenin-mediated autophagy and promotes EGFR-TKI resistance in lung adenocarcinoma.,2025,10.1038/s41417-024-00843-y,https://pubmed.ncbi.nlm.nih.gov/39587349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,38856307,A novel missense mutation of CCDC34 causes male infertility with oligoasthenoteratozoospermia in a consanguineous Pakistani family.,2024,10.4103/aja202432,https://pubmed.ncbi.nlm.nih.gov/38856307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,37415626,MNX1 facilitates the malignant progress of lung adenocarcinoma through transcriptionally upregulating CCDC34.,2023,10.3892/ol.2023.13911,https://pubmed.ncbi.nlm.nih.gov/37415626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,41406802,"Genetic diversity, population structure and selective sweeps in Italian Leccese chickens.",2026,10.1016/j.psj.2025.106280,https://pubmed.ncbi.nlm.nih.gov/41406802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,34348960,Homozygous mutations in &lt;i&gt;CCDC34&lt;/i&gt; cause male infertility with oligoasthenoteratozoospermia in humans and mice.,2022,10.1136/jmedgenet-2021-107919,https://pubmed.ncbi.nlm.nih.gov/34348960/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,34767735,RABL2A-CCDC34 Axis Promotes Sorafenib Resistance in Hepatocellular Carcinoma.,2021,10.1089/dna.2021.0473,https://pubmed.ncbi.nlm.nih.gov/34767735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,32021254,Up-Regulated CCDC34 Contributes to the Proliferation and Metastasis of Hepatocellular Carcinoma.,2020,10.2147/ott.s237399,https://pubmed.ncbi.nlm.nih.gov/32021254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,29257799,Expression of Coiled-Coil Domain Containing 34 (CCDC34) and its Prognostic Significance in Pancreatic Adenocarcinoma.,2017,10.12659/msm.907951,https://pubmed.ncbi.nlm.nih.gov/29257799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,30458457,High Expression of CCDC34 Is Associated with Poor Survival in Cervical Cancer Patients.,2018,10.12659/msm.913346,https://pubmed.ncbi.nlm.nih.gov/30458457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,29115580,"Overexpression of CCDC34 in colorectal cancer and its involvement in tumor growth, apoptosis and invasion.",2018,10.3892/mmr.2017.7860,https://pubmed.ncbi.nlm.nih.gov/29115580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,29397026,Overexpression of Coiled-Coil Domain-Containing Protein 34 (CCDC34) and its Correlation with Angiogenesis in Esophageal Squamous Cell Carcinoma.,2018,10.12659/msm.908335,https://pubmed.ncbi.nlm.nih.gov/29397026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,33188157,Development and validation of a novel prognostic signature in gastric adenocarcinoma.,2020,10.18632/aging.104161,https://pubmed.ncbi.nlm.nih.gov/33188157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,38097166,A Human Adenovirus C Infection-Related Gene Panel for Predicting Survival and Treatment Responsiveness in Glioma Patients.,2024,10.1016/j.wneu.2023.12.051,https://pubmed.ncbi.nlm.nih.gov/38097166/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,26312564,"CCDC34 is up-regulated in bladder cancer and regulates bladder cancer cell proliferation, apoptosis and migration.",2015,10.18632/oncotarget.4624,https://pubmed.ncbi.nlm.nih.gov/26312564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,35356681,Chromosomal Region 11p14.1 is Associated with Pharmacokinetics and Pharmacodynamics of Bisoprolol.,2022,10.2147/pgpm.s352719,https://pubmed.ncbi.nlm.nih.gov/35356681/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,29255427,Weighted Gene Co-expression Network Analysis Identifies FKBP11 as a Key Regulator in Acute Aortic Dissection through a NF-kB Dependent Pathway.,2017,10.3389/fphys.2017.01010,https://pubmed.ncbi.nlm.nih.gov/29255427/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC34,ENSG00000109881,Unsafe,35100979,Genome-wide run of homozygosity analysis reveals candidate genomic regions associated with environmental adaptations of Tibetan native chickens.,2022,10.1186/s12864-021-08280-z,https://pubmed.ncbi.nlm.nih.gov/35100979/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC38,ENSG00000165972,Unsafe,38038747,CCDC146 is required for sperm flagellum biogenesis and male fertility in mice.,2023,10.1007/s00018-023-05025-x,https://pubmed.ncbi.nlm.nih.gov/38038747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC38,ENSG00000165972,Unsafe,35587122,CCDC38 is required for sperm flagellum biogenesis and male fertility in mice.,2022,10.1242/dev.200516,https://pubmed.ncbi.nlm.nih.gov/35587122/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC38,ENSG00000165972,Unsafe,27278724,"Identification and characteristics of the testes-specific gene, Ccdc38, in mice.",2016,10.3892/mmr.2016.5360,https://pubmed.ncbi.nlm.nih.gov/27278724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC38,ENSG00000165972,Unsafe,31255637,Proteomics and single-cell RNA analysis of Akap4-knockout mice model confirm indispensable role of Akap4 in spermatogenesis.,2019,10.1016/j.ydbio.2019.06.017,https://pubmed.ncbi.nlm.nih.gov/31255637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC38,ENSG00000165972,Unsafe,24786987,Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction.,2014,10.1371/journal.pgen.1004314,https://pubmed.ncbi.nlm.nih.gov/24786987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC38,ENSG00000165972,Unsafe,25074808,Proteomic analysis of mammalian sperm cells identifies new components of the centrosome.,2014,10.1242/jcs.157008,https://pubmed.ncbi.nlm.nih.gov/25074808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC38,ENSG00000165972,Unsafe,21946350,Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.,2011,10.1038/ng.941,https://pubmed.ncbi.nlm.nih.gov/21946350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC63,ENSG00000173093,Unsafe,41828368,Genetic Influence of &lt;i&gt;CCDC63&lt;/i&gt; Polymorphisms on Alcohol-Induced Dyslipidemia in a Korean Cohort.,2026,10.3390/ijms27052134,https://pubmed.ncbi.nlm.nih.gov/41828368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC63,ENSG00000173093,Unsafe,38750582,Comparative whole-genome resequencing to uncover selection signatures linked to litter size in Hu Sheep and five other breeds.,2024,10.1186/s12864-024-10396-x,https://pubmed.ncbi.nlm.nih.gov/38750582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC63,ENSG00000173093,Unsafe,38765163,Identifying the miRNA-gene networks contributes to exploring paravertebral muscle degeneration's underlying pathogenesis and therapy strategy.,2024,10.1016/j.heliyon.2024.e30517,https://pubmed.ncbi.nlm.nih.gov/38765163/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC63,ENSG00000173093,Unsafe,26501274,CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines Identified Ccdc63 as Essential for Spermiogenesis.,2015,10.3390/ijms161024732,https://pubmed.ncbi.nlm.nih.gov/26501274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC63,ENSG00000173093,Unsafe,35015293,Histone Methylation Regulates Gene Expression in the Round Spermatids to Set the RNA Payloads of Sperm.,2022,10.1007/s43032-021-00837-3,https://pubmed.ncbi.nlm.nih.gov/35015293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC63,ENSG00000173093,Unsafe,29632305,New Common and Rare Variants Influencing Metabolic Syndrome and Its Individual Components in a Korean Population.,2018,10.1038/s41598-018-23074-2,https://pubmed.ncbi.nlm.nih.gov/29632305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC63,ENSG00000173093,Unsafe,24277619,"ALDH2 is associated to alcohol dependence and is the major genetic determinant of ""daily maximum drinks"" in a GWAS study of an isolated rural Chinese sample.",2014,10.1002/ajmg.b.32213,https://pubmed.ncbi.nlm.nih.gov/24277619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC63,ENSG00000173093,Unsafe,30226566,"Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease.",2018,10.3892/ijmm.2018.3852,https://pubmed.ncbi.nlm.nih.gov/30226566/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC65,ENSG00000139537,Unsafe,41300775,Endometrial Signatures of Subfertility in Beef Heifers Reveal Dysregulation of MAPK Signaling and Ciliary Function.,2025,10.3390/genes16111323,https://pubmed.ncbi.nlm.nih.gov/41300775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC65,ENSG00000139537,Unsafe,41264116,The essential role of cytoskeleton and ciliary abnormalities in the development of congenital pulmonary airway malformations.,2025,10.1007/s00383-025-06250-0,https://pubmed.ncbi.nlm.nih.gov/41264116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC65,ENSG00000139537,Unsafe,35844805,"CCDC65, a Gene Knockout that leads to Early Death of Mice, acts as a potentially Novel Tumor Suppressor in Lung Adenocarcinoma.",2022,10.7150/ijbs.69332,https://pubmed.ncbi.nlm.nih.gov/35844805/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC65,ENSG00000139537,Unsafe,38008820,Ropivacaine suppresses the progression of renal cell carcinoma through regulating the lncRNA RMRP/EZH2/CCDC65 axis.,2024,10.1007/s40199-023-00492-w,https://pubmed.ncbi.nlm.nih.gov/38008820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC65,ENSG00000139537,Unsafe,34335983,CCDC65 as a new potential tumor suppressor induced by metformin inhibits activation of AKT1 via ubiquitination of ENO1 in gastric cancer.,2021,10.7150/thno.54961,https://pubmed.ncbi.nlm.nih.gov/34335983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC65,ENSG00000139537,Unsafe,35052387,A Nonsense Variant in CCDC65 Gene Causes Respiratory Failure Associated with Increased Lamb Mortality in French Lacaune Dairy Sheep.,2021,10.3390/genes13010045,https://pubmed.ncbi.nlm.nih.gov/35052387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC65,ENSG00000139537,Unsafe,36533556,Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants.,2022,10.1242/dmm.049568,https://pubmed.ncbi.nlm.nih.gov/36533556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC65,ENSG00000139537,Unsafe,23991085,CCDC65 mutation causes primary ciliary dyskinesia with normal ultrastructure and hyperkinetic cilia.,2013,10.1371/journal.pone.0072299,https://pubmed.ncbi.nlm.nih.gov/23991085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC65,ENSG00000139537,Unsafe,34976225,Comparative analysis of mRNA transcripts of HT-29 cell line expressed in identical quantities for pathogenic E. coli strains UM146 and UM147 with control Escherichia coli Nissle 1917.,2022,10.7150/jgen.67277,https://pubmed.ncbi.nlm.nih.gov/34976225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC65,ENSG00000139537,Unsafe,24094744,Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia.,2013,10.1016/j.ajhg.2013.08.015,https://pubmed.ncbi.nlm.nih.gov/24094744/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC65,ENSG00000139537,Unsafe,29167384,DRC2/CCDC65 is a central hub for assembly of the nexin-dynein regulatory complex and other regulators of ciliary and flagellar motility.,2018,10.1091/mbc.e17-08-0510,https://pubmed.ncbi.nlm.nih.gov/29167384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC65,ENSG00000139537,Unsafe,29467202,Primary ciliary dyskinesia with normal ultrastructure: three-dimensional tomography detects absence of DNAH11.,2018,10.1183/13993003.01809-2017,https://pubmed.ncbi.nlm.nih.gov/29467202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC65,ENSG00000139537,Unsafe,28915070,Value of transmission electron microscopy for primary ciliary dyskinesia diagnosis in the era of molecular medicine: Genetic defects with normal and non-diagnostic ciliary ultrastructure.,2017,10.1080/01913123.2017.1362088,https://pubmed.ncbi.nlm.nih.gov/28915070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC65,ENSG00000139537,Unsafe,25802884,Carrier frequencies of eleven mutations in eight genes associated with primary ciliary dyskinesia in the Ashkenazi Jewish population.,2015,10.1002/mgg3.124,https://pubmed.ncbi.nlm.nih.gov/25802884/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC65,ENSG00000139537,Unsafe,17089017,"Cloning and characterization of a novel sperm tail protein, NYD-SP28.",2006,10.3892/ijmm.18.6.1119,https://pubmed.ncbi.nlm.nih.gov/17089017/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,40983631,Induction of ferroptosis in prostate cancer by CCDC7&lt;sub&gt;19-13&lt;/sub&gt; via TRIM21-mediated ubiquitination of SLC7A11.,2026,10.1038/s41418-025-01580-x,https://pubmed.ncbi.nlm.nih.gov/40983631/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,38540995,Rare Mutations in CCDC7 Contribute to Early-Onset Preeclampsia by Inhibiting Trophoblast Migration and Invasion.,2024,10.3390/jpm14030253,https://pubmed.ncbi.nlm.nih.gov/38540995/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,38225404,A protein-encoding CCDC7 circular RNA inhibits the progression of prostate cancer by up-regulating FLRT3.,2024,10.1038/s41698-024-00503-2,https://pubmed.ncbi.nlm.nih.gov/38225404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,38936216,Exosomal circ_CCDC7/gga-miR-6568-3p/Pax7 axis accelerates the differentiation of chicken embryonic stem cells infected with subgroup J avian leukosis virus.,2024,10.1016/j.psj.2024.103898,https://pubmed.ncbi.nlm.nih.gov/38936216/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,37028722,Thickness effects of polyethylene and biodegradable film residuals on soil properties and dryland maize productivity.,2023,10.1016/j.chemosphere.2023.138602,https://pubmed.ncbi.nlm.nih.gov/37028722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,32669853,CCDC7 Activates Interleukin-6 and Vascular Endothelial Growth Factor to Promote Proliferation via the JAK-STAT3 Pathway in Cervical Cancer Cells.,2020,10.2147/ott.s244663,https://pubmed.ncbi.nlm.nih.gov/32669853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,37325203,CCDC7 Activates Interleukin-6 and Vascular Endothelial Growth Factor to Promote Proliferation via the JAK-STAT3 Pathway in Cervical Cancer Cells [Retraction].,2023,10.2147/ott.s424822,https://pubmed.ncbi.nlm.nih.gov/37325203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,36736218,Thickness-dependent release of microplastics and phthalic acid esters from polythene and biodegradable residual films in agricultural soils and its related productivity effects.,2023,10.1016/j.jhazmat.2023.130897,https://pubmed.ncbi.nlm.nih.gov/36736218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,36274151,Temporal associations between leukocytes DNA methylation and blood lipids: a longitudinal study.,2022,10.1186/s13148-022-01356-x,https://pubmed.ncbi.nlm.nih.gov/36274151/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,25706396,RNA interference of Biot2 induces G1 phase arrest and apoptosis in mouse colorectal cancer cell line.,2015,10.3727/096504014x14146137738583,https://pubmed.ncbi.nlm.nih.gov/25706396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,26345800,"Expression and antibody generation of the cancer-testis antigen, BIOT2-S.",2015,10.4238/2015.july.31.17,https://pubmed.ncbi.nlm.nih.gov/26345800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,19950598,[Analysis of expression pattern of a novel testis-highly expressed gene Biot2-L and the primary study on its role in testis development].,2009,,https://pubmed.ncbi.nlm.nih.gov/19950598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,19277478,"RNA interference against Biot2, a novel mouse testis-specific gene, inhibits the growth of tumor cells.",2009,10.2478/s11658-009-0004-6,https://pubmed.ncbi.nlm.nih.gov/19277478/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,32127942,Bioinformatics analysis and identification of potential genes related to pathogenesis of cervical intraepithelial neoplasia.,2020,10.7150/jca.38211,https://pubmed.ncbi.nlm.nih.gov/32127942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,17618559,"[Effects of the novel tumor/testis antigen, Biot2, on proliferation of NIH3T3 cell].",2007,,https://pubmed.ncbi.nlm.nih.gov/17618559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,17488598,[Construction of the prokaryotic expression vector and expression of murine testis-specific gene Biot2].,2007,,https://pubmed.ncbi.nlm.nih.gov/17488598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,25626716,Genomic structural variants are linked with intellectual disability.,2015,10.1007/s00702-015-1366-8,https://pubmed.ncbi.nlm.nih.gov/25626716/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,24650168,De novo SCN2A splice site mutation in a boy with Autism spectrum disorder.,2014,10.1186/1471-2350-15-35,https://pubmed.ncbi.nlm.nih.gov/24650168/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,18027117,Expression of human Biot2 and its potential function on carcinogenesis in endometrial cancer.,2007,10.1080/00016340701736946,https://pubmed.ncbi.nlm.nih.gov/18027117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,21109960,Overexpression of the hBiot2 gene is associated with development of human cervical cancer.,2011,10.3892/or_00001044,https://pubmed.ncbi.nlm.nih.gov/21109960/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC7,ENSG00000216937,Unsafe,40363061,Urea-Formaldehyde Strengthened by Polyvinyl Alcohol: Impact on Mulch Film Properties and Cucumber Cultivation.,2025,10.3390/polym17091277,https://pubmed.ncbi.nlm.nih.gov/40363061/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC89,ENSG00000179071,Unsafe,41074672,The Cilia-Associated Protein CCDC89 Is Dispensable for Male Fertility in Mice.,2026,10.1002/cm.70057,https://pubmed.ncbi.nlm.nih.gov/41074672/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC89,ENSG00000179071,Unsafe,40591933,CCDC89 is required for optimal sperm motility and male fertility in mammals.,2025,10.1093/humrep/deaf126,https://pubmed.ncbi.nlm.nih.gov/40591933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC89,ENSG00000179071,Unsafe,30486374,Effect of a Toothpaste/Mouthwash Containing Carica papaya Leaf Extract on Interdental Gingival Bleeding: A Randomized Controlled Trial.,2018,10.3390/ijerph15122660,https://pubmed.ncbi.nlm.nih.gov/30486374/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC89,ENSG00000179071,Unsafe,14648848,"Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse.",2003,10.1002/dvdy.10406,https://pubmed.ncbi.nlm.nih.gov/14648848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,39250516,"Genetic variation in CCDC93 is associated with elevated central systolic blood pressure, impaired arterial relaxation, and mitochondrial dysfunction.",2024,10.1371/journal.pgen.1011151,https://pubmed.ncbi.nlm.nih.gov/39250516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,42495818,"CROP2, a Retriever-PROPPIN complex mediating protein export from endosomes to the plasma membrane in human cells.",2026,10.7554/elife.109403,https://pubmed.ncbi.nlm.nih.gov/42495818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,40448120,CCDC22 mutations that impair COMMD binding cause attenuated 3C/Ritscher-Schinzel syndrome.,2025,10.1186/s12920-025-02168-7,https://pubmed.ncbi.nlm.nih.gov/40448120/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,40601774,Ritscher-Schinzel syndrome can be characterized as an endosomal recyclinopathy.,2025,10.1126/scitranslmed.adt2426,https://pubmed.ncbi.nlm.nih.gov/40601774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,40580479,Phenotypic screens for SIRPA expression reveal RAB21 as a general regulator of macrophage surface identity.,2025,10.1016/j.celrep.2025.115921,https://pubmed.ncbi.nlm.nih.gov/40580479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,41112769,Serum proteomic profiling during the periovulatory period identifies preliminary candidate biomarkers of oocyte maturation in deslorelin-induced ovulation in dogs.,2025,10.7717/peerj.20106,https://pubmed.ncbi.nlm.nih.gov/41112769/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,36618652,"CCDC22 and CCDC93, two potential retriever-interacting proteins, are required for root and root hair growth in Arabidopsis.",2022,10.3389/fpls.2022.1051503,https://pubmed.ncbi.nlm.nih.gov/36618652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,38459129,Structure and interactions of the endogenous human Commander complex.,2024,10.1038/s41594-024-01246-1,https://pubmed.ncbi.nlm.nih.gov/38459129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,37172566,Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome.,2023,10.1016/j.cell.2023.04.003,https://pubmed.ncbi.nlm.nih.gov/37172566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,34943955,Commander Complex-A Multifaceted Operator in Intracellular Signaling and Cargo.,2021,10.3390/cells10123447,https://pubmed.ncbi.nlm.nih.gov/34943955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,38062209,Structural organization of the retriever-CCC endosomal recycling complex.,2024,10.1038/s41594-023-01184-4,https://pubmed.ncbi.nlm.nih.gov/38062209/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,31630160,A common variant in CCDC93 protects against myocardial infarction and cardiovascular mortality by regulating endosomal trafficking of low-density lipoprotein receptor.,2020,10.1093/eurheartj/ehz727,https://pubmed.ncbi.nlm.nih.gov/31630160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,33262129,Regulation of murine copper homeostasis by members of the COMMD protein family.,2021,10.1242/dmm.045963,https://pubmed.ncbi.nlm.nih.gov/33262129/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,36445330,COMMD3-Mediated Endosomal Trafficking of HER2 Inhibits the Progression of Ovarian Carcinoma.,2023,10.1158/1541-7786.mcr-22-0333,https://pubmed.ncbi.nlm.nih.gov/36445330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,31537807,Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling.,2019,10.1038/s41467-019-12221-6,https://pubmed.ncbi.nlm.nih.gov/31537807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,32955644,Integrative Analysis of MicroRNAs and mRNAs in LPS-Induced Macrophage Inflammation Based on Adipose Tissue Stem Cell Therapy.,2021,10.1007/s10753-020-01345-3,https://pubmed.ncbi.nlm.nih.gov/32955644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,30959277,COMMD10-Guided Phagolysosomal Maturation Promotes Clearance of Staphylococcus aureus in Macrophages.,2019,10.1016/j.isci.2019.03.024,https://pubmed.ncbi.nlm.nih.gov/30959277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,31658251,Ancestral reconstruction of protein interaction networks.,2019,10.1371/journal.pcbi.1007396,https://pubmed.ncbi.nlm.nih.gov/31658251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,25355947,COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.,2015,10.1091/mbc.e14-06-1073,https://pubmed.ncbi.nlm.nih.gov/25355947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCDC93,ENSG00000125633,Unsafe,29545368,The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking.,2018,10.1161/circresaha.117.312004,https://pubmed.ncbi.nlm.nih.gov/29545368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,42653452,The CCHCR1-UBAP2L Interaction Promotes UBAP2L Release from P-Bodies for Stress Granule Assembly.,2026,10.3390/ijms27167451,https://pubmed.ncbi.nlm.nih.gov/42653452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,42057949,Integrative pan-cancer analysis identifies CCHCR1 as a prognostic biomarker and therapeutic target driving EMT in hepatocellular carcinoma via PI3K/AKT activation.,2026,10.1016/j.gendis.2025.101960,https://pubmed.ncbi.nlm.nih.gov/42057949/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,40883668,CCHCR1 links P-body proteins to the centrosome and is required for ciliogenesis through interacting with OFD1 and PCM1.,2025,10.1186/s11658-025-00780-0,https://pubmed.ncbi.nlm.nih.gov/40883668/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,41210689,Local Genetic Correlations and Pleiotropy Reveal Shared Genetic Architecture Between COVID-19 Phenotypes and Prostate Cancer in European Populations.,2025,10.7150/jca.111126,https://pubmed.ncbi.nlm.nih.gov/41210689/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,40730494,Genome Variation in Alcohol Use Disorder by Whole-Exome Sequencing.,2025,10.1111/adb.70070,https://pubmed.ncbi.nlm.nih.gov/40730494/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,38230433,Segregation of nascent GPCRs in the ER-to-Golgi transport by CCHCR1 via direct interaction.,2024,10.1242/jcs.261685,https://pubmed.ncbi.nlm.nih.gov/38230433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,38128007,Cell cycle regulation of the psoriasis associated gene CCHCR1 by transcription factor E2F1.,2023,10.1371/journal.pone.0294661,https://pubmed.ncbi.nlm.nih.gov/38128007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,40931197,Upfront whole blood transcriptional patterns in patients receiving immune checkpoint inhibitors associate with clinical outcome.,2025,10.1007/s00262-025-04155-4,https://pubmed.ncbi.nlm.nih.gov/40931197/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,37830419,"Clinical Findings, Response to Steroid Treatment, and Recurrence Rate in Alopecia Areata Patients with or without a Nonsynonymous Variant of Coiled-Coil Alpha-Helical Rod Protein 1.",2023,10.5021/ad.22.227,https://pubmed.ncbi.nlm.nih.gov/37830419/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,40552851,Identification of a Risk Allele at SLC41A3 and a Protective Allele HLA-DPB1*02:01 Associated with Sarcopenia in Japanese.,2025,10.1159/000545298,https://pubmed.ncbi.nlm.nih.gov/40552851/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,34356904,The Alopecia Areata Phenotype Is Induced by the Water Avoidance Stress Test In cchcr1-Deficient Mice.,2021,10.3390/biomedicines9070840,https://pubmed.ncbi.nlm.nih.gov/34356904/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,37550236,Evaluation of the Involvement of Coiled-coil α-helical Rod Protein 1 (CCHCR1) in Imiquimod-induced Psoriasis Models.,2023,10.5021/ad.21.279,https://pubmed.ncbi.nlm.nih.gov/37550236/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,40227503,Clinical Outcomes and Genomic Alterations in Gleason Score 10 Prostate Cancer.,2025,10.3390/cancers17071055,https://pubmed.ncbi.nlm.nih.gov/40227503/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,39175753,"GWAS-significant loci and severe COVID-19: analysis of associations, link with thromboinflammation syndrome, gene-gene, and gene-environmental interactions.",2024,10.3389/fgene.2024.1434681,https://pubmed.ncbi.nlm.nih.gov/39175753/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,36877681,Assembly and regulation of the mammalian mRNA processing body.,2023,10.1371/journal.pone.0282496,https://pubmed.ncbi.nlm.nih.gov/36877681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,29866042,Intracellular signalling pathways and cytoskeletal functions converge on the psoriasis candidate gene CCHCR1 expressed at P-bodies and centrosomes.,2018,10.1186/s12864-018-4810-y,https://pubmed.ncbi.nlm.nih.gov/29866042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,33150273,Analysis of Glucocorticoid-Related Genes Reveal CCHCR1 as a New Candidate Gene for Type 2 Diabetes.,2020,10.1210/jendso/bvaa121,https://pubmed.ncbi.nlm.nih.gov/33150273/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,36280838,CCHCR1-astrin interaction promotes centriole duplication through recruitment of CEP72.,2022,10.1186/s12915-022-01437-6,https://pubmed.ncbi.nlm.nih.gov/36280838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,32580135,Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss.,2020,10.1016/j.ebiom.2020.102810,https://pubmed.ncbi.nlm.nih.gov/32580135/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,23189171,"Centrosomal localization of the psoriasis candidate gene product, CCHCR1, supports a role in cytoskeletal organization.",2012,10.1371/journal.pone.0049920,https://pubmed.ncbi.nlm.nih.gov/23189171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,39688065,"Genome-Wide Association Study of Persistent Anal Human Papillomavirus Infection Among HIV-Positive Males in Taizhou, China: A Cohort Study.",2024,10.1002/jmv.70126,https://pubmed.ncbi.nlm.nih.gov/39688065/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,38815935,A genome-wide meta-analysis of palmoplantar pustulosis implicates T&lt;sub&gt;H&lt;/sub&gt;2 responses and cigarette smoking in disease pathogenesis.,2024,10.1016/j.jaci.2024.05.015,https://pubmed.ncbi.nlm.nih.gov/38815935/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,38654296,Influence of pharmacogenomic polymorphisms on allopurinol-induced cutaneous adverse drug reactions in Thai patients.,2024,10.1186/s12920-024-01874-y,https://pubmed.ncbi.nlm.nih.gov/38654296/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,35991636,Genome-wide association study of hyperthyroidism based on electronic medical record from Taiwan.,2022,10.3389/fmed.2022.830621,https://pubmed.ncbi.nlm.nih.gov/35991636/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,36423071,"Allelic Variants of HLA-C Upstream Region, PSORS1C3, MICA, TNFA and Genes Involved in Epidermal Homeostasis and Barrier Function Influence the Clinical Response to Anti-IL-12/IL-23 Treatment of Patients with Psoriasis.",2022,10.3390/vaccines10111977,https://pubmed.ncbi.nlm.nih.gov/36423071/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,34825969,"Placental-Cadherin, a biomarker for local immune status and poor prognosis among patients with tongue squamous cell carcinoma.",2022,10.1007/s00405-021-07181-x,https://pubmed.ncbi.nlm.nih.gov/34825969/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,32978904,Diagnostic significance and carcinogenic mechanism of pan-cancer gene POU5F1 in liver hepatocellular carcinoma.,2020,10.1002/cam4.3486,https://pubmed.ncbi.nlm.nih.gov/32978904/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,28393889,Genetic architecture of gene expression underlying variation in host response to porcine reproductive and respiratory syndrome virus infection.,2017,10.1038/srep46203,https://pubmed.ncbi.nlm.nih.gov/28393889/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,22985493,Common genetic variants associated with disease from genome-wide association studies are mutually exclusive in prostate cancer and rheumatoid arthritis.,2013,10.1111/j.1464-410x.2012.11492.x,https://pubmed.ncbi.nlm.nih.gov/22985493/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCHCR1,ENSG00000204536,Unsafe,16096103,Mapping and identifying genes for asthma and psoriasis.,2005,10.1098/rstb.2005.1684,https://pubmed.ncbi.nlm.nih.gov/16096103/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42650923,Serum CC-Chemokine Profiling in Alcohol-Associated Liver Disease: Focus on MIP-3α/CCL20 as a Biomarker of Disease Severity.,2026,10.3390/diagnostics16162520,https://pubmed.ncbi.nlm.nih.gov/42650923/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42721456,Cytokine concentrations in pediatric primary mediastinal large B cell lymphoma correlate with disease extent and outcome.,2026,10.1182/bloodadvances.2026021463,https://pubmed.ncbi.nlm.nih.gov/42721456/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42764272,Tissue Olink Proteomics Analysis Reveals CCL17 as a Potential Biomarker in Patients With Pressure Ulcers.,2026,10.1111/1346-8138.70492,https://pubmed.ncbi.nlm.nih.gov/42764272/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42682749,"Pediatric atopic dermatitis: biomarker advances in severity, persistence, and non-invasive monitoring.",2026,10.3389/fped.2026.1902799,https://pubmed.ncbi.nlm.nih.gov/42682749/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42794489,"Peripheral Immune Modulation in Atopic Dermatitis During Dupilumab or Baricitinib Treatment Is Limited, as Assessed by Proteomic, Transcriptomic, and Torque Teno Virus Analyses.",2026,10.3390/ijms27188056,https://pubmed.ncbi.nlm.nih.gov/42794489/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42158148,Markers of neuroinflammation in the CSF of patients with difficult to treat psychiatric disease.,2026,10.3389/fpsyt.2026.1665447,https://pubmed.ncbi.nlm.nih.gov/42158148/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42074100,CC Chemokines in Myocardial Fibrosis: Regulatory Networks of CCL17 and Emerging Therapeutic Implications.,2026,10.3390/ijms27083458,https://pubmed.ncbi.nlm.nih.gov/42074100/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,41609895,Novel Therapeutic Strategies for Atopic Dermatitis: Biomarker Modulation and Clinical Implications. A Systematic Review.,2026,10.1007/s12016-025-09129-z,https://pubmed.ncbi.nlm.nih.gov/41609895/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,41573581,The relationship of chemokine levels and the type of symptoms caused by NSAIDs or alcohol in patients with NSAIDs-exacerbated respiratory disease.,2025,10.3389/fimmu.2025.1722171,https://pubmed.ncbi.nlm.nih.gov/41573581/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,41460722,The CCL17-CCR4 Axis Is Critical for Mutant STAT6-Mediated Microenvironmental Remodeling and Therapeutic Resistance in Relapsed/Refractory Diffuse Large B-Cell Lymphoma.,2026,10.1158/2326-6066.cir-25-0583,https://pubmed.ncbi.nlm.nih.gov/41460722/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,41291326,The CCL17/CCL22-CCR4 Axis in Pain Pathogenesis: A Comprehensive Review of Immune-Mediated Mechanisms and Therapeutic Opportunities.,2025,10.1007/s12035-025-05550-9,https://pubmed.ncbi.nlm.nih.gov/41291326/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42510549,A &lt;i&gt;Torilis japonica&lt;/i&gt; Extract-GHK-Cu Complex Attenuates Th2 Cytokines and Promotes Keratinocyte Recovery: A Potential Antioxidant Strategy for Atopic Dermatitis.,2026,10.3390/antiox15070818,https://pubmed.ncbi.nlm.nih.gov/42510549/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42019646,CCL17 drives the expression of MMP9 and MMP13 expression via ERK1/2 and NF-κB signaling pathways in rheumatoid arthritis.,2026,10.1016/j.cellsig.2026.112551,https://pubmed.ncbi.nlm.nih.gov/42019646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,41853463,Plasma proteomic profiles of patients with atopic dermatitis with moderate-to-severe pruritus treated with a single dose of nemolizumab.,2026,10.1016/j.xjidi.2026.100457,https://pubmed.ncbi.nlm.nih.gov/41853463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42359364,CCL17-neutralizing and esterase-responsive core-shell microgels for endogenous Tregs recruitment and functional enhancement in myocardial infarction.,2026,10.1016/j.bioactmat.2026.06.012,https://pubmed.ncbi.nlm.nih.gov/42359364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42212432,Comparison of Serum TARC Levels at Term-Equivalent Age Between Preterm and Term Infants.,2026,10.1155/jimr/3984014,https://pubmed.ncbi.nlm.nih.gov/42212432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42621097,PIWIL2 drives stroke progression via modulation of NF-κB signaling.,2026,10.1016/j.omtn.2026.103037,https://pubmed.ncbi.nlm.nih.gov/42621097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42652208,Polynucleotides Attenuate Atopic Dermatitis-like Inflammatory Signaling in Keratinocytes and Macrophages.,2026,10.3390/biomedicines14081826,https://pubmed.ncbi.nlm.nih.gov/42652208/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,39905630,"Increased Levels of Inflammatory Proteins, Including TARC/CCL17, in Skin of AD Patients During JAK Inhibitor Treatment.",2025,10.1111/cea.14637,https://pubmed.ncbi.nlm.nih.gov/39905630/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42159891,"Understanding Infantile Atopic Dermatitis: A Review of Environmental, Familial, Genetic and Microbial Influences.",2026,10.1007/s11882-026-01272-7,https://pubmed.ncbi.nlm.nih.gov/42159891/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42550205,"Impact of sublingual immunotherapy with dust mite drops on ECP, TARC, VCAM-1 inflammatory status in patients with allergic rhinitis.",2026,10.1080/1750743x.2026.2704434,https://pubmed.ncbi.nlm.nih.gov/42550205/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,41613951,Systemic Immune Alterations in Paediatric Classical Hodgkin Lymphoma With CCL17 and MCP-4 as Diagnostic and Predictive Biomarkers.,2026,10.1002/jha2.70228,https://pubmed.ncbi.nlm.nih.gov/41613951/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42279396,Classic Hodgkin Lymphoma Beyond the Lymph Node: A Systemic Immunobiological Paradigm.,2026,10.3390/cancers18111813,https://pubmed.ncbi.nlm.nih.gov/42279396/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,40990939,Tumor-specific immune responses and biomarkers in pediatric patients with high-risk Hodgkin lymphoma.,2026,10.1182/bloodadvances.2025016797,https://pubmed.ncbi.nlm.nih.gov/40990939/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,41200192,Trends in allergen-reactive CRTH2+ T cells and TARC associated with successful outcomes in a phase 2 cashew oral immunotherapy study.,2025,10.3389/fimmu.2025.1655975,https://pubmed.ncbi.nlm.nih.gov/41200192/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42774716,Lymphocyte signal transduction defects in cutaneous sarcoidosis and implications for treatment.,2026,10.3389/fimmu.2026.1711377,https://pubmed.ncbi.nlm.nih.gov/42774716/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42747103,Drug-induced enterocolitis syndrome triggered by mefenamic acid in a child: TARC and DLST as diagnostic aids.,2026,10.1111/pai.70486,https://pubmed.ncbi.nlm.nih.gov/42747103/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42500847,Skin Abnormalities at Checkpoint Inhibitor Therapy Initiation Are Associated With Skin Rash Development in Oncology Patients.,2026,10.1111/all.70448,https://pubmed.ncbi.nlm.nih.gov/42500847/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42199412,Systemic toxicity and immunotoxicity studies of glucose oxidase-loaded extracellular vesicles derived from lung cancer cells.,2026,10.3389/fimmu.2026.1842887,https://pubmed.ncbi.nlm.nih.gov/42199412/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42196608,"Regulatory T Cells in Hepatocellular Carcinoma: Spatial Niches, Biomarkers, and Clinical Implications.",2026,10.3390/ijms27104630,https://pubmed.ncbi.nlm.nih.gov/42196608/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,42008513,Serum proteomic changes in atopic dermatitis patients treated with cyclosporine.,2026,10.1371/journal.pone.0346686,https://pubmed.ncbi.nlm.nih.gov/42008513/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,40827120,Atopic Dermatitis Management: from Conventional Therapies to Biomarker-Driven Treatment Approaches.,2025,10.4062/biomolther.2025.081,https://pubmed.ncbi.nlm.nih.gov/40827120/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL17,ENSG00000102970,Unsafe,8702936,Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector.,1996,10.1074/jbc.271.35.21514,https://pubmed.ncbi.nlm.nih.gov/8702936/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,42785548,Glycolysis-derived lactate contributes to H3K18la modification and CCL27 expression to promote placental angiogenesis.,2026,10.1016/j.lfs.2026.124700,https://pubmed.ncbi.nlm.nih.gov/42785548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,41718152,Inflammatory Mediators of Alzheimer's Disease Characterized in a Mouse Model (APP/PS1).,2026,10.3390/neurosci7010023,https://pubmed.ncbi.nlm.nih.gov/41718152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,42840476,Modulatory effects of interferon-γ and interleukin-13 on tumor necrosis factor-α-induced chemokine gene expression in canine keratinocytes.,2026,10.1016/j.vas.2026.100876,https://pubmed.ncbi.nlm.nih.gov/42840476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,41752086,Circulating Clues in Ménière's Disease: Elevated Cell-Free DNA and a Pro-Inflammatory Signature in Patients' Blood.,2026,10.3390/ijms27041948,https://pubmed.ncbi.nlm.nih.gov/41752086/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,42676327,Case Report: Effective IL-4/IL-13 axis suppression and resolution of severe atopic dermatitis by dupilumab monotherapy in a patient with IPEX syndrome.,2026,10.3389/fimmu.2026.1923415,https://pubmed.ncbi.nlm.nih.gov/42676327/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,41050670,"CCR10: a comprehensive review of its function, phylogeny, role in immune cell trafficking and disease pathogenesis.",2025,10.3389/fimmu.2025.1599277,https://pubmed.ncbi.nlm.nih.gov/41050670/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,41904508,Research based on serine metabolism indicates mesenchymal stem cells alleviate psoriasis by regulating the PSPH-PINK1-Parkin-NLRP3 pathway in HaCaT.,2026,10.1186/s13287-026-04964-z,https://pubmed.ncbi.nlm.nih.gov/41904508/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,42114565,Microarray Gene Expression Analysis of Lesional Skin in Canine Vesicular Cutaneous Lupus Erythematosus (VCLE).,2026,10.1111/vde.70084,https://pubmed.ncbi.nlm.nih.gov/42114565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,40975172,Rules of engagement: Determinants of chemokine receptor activation and selectivity by CCL27 and CCL28.,2025,10.1016/j.jbc.2025.110736,https://pubmed.ncbi.nlm.nih.gov/40975172/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,41749925,The Role of Rarely Studied Chemokines in Tumor Progression in Multiple Myeloma (MM).,2026,10.3390/cancers18040673,https://pubmed.ncbi.nlm.nih.gov/41749925/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,42581788,Selective Anti-Inflammatory Actions of Curcumin on Cytokine Pathways in Major Depressive Disorder.,2026,10.1002/brb3.71672,https://pubmed.ncbi.nlm.nih.gov/42581788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,39689453,BP-3 exposure at environmentally relevant concentrations induced male developmental reproductive toxicity via ER/CCL27/ROS pathway in mice.,2025,10.1016/j.ecoenv.2024.117556,https://pubmed.ncbi.nlm.nih.gov/39689453/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,40221607,Salivary chemokines and growth factors in patients with ischemic stroke.,2025,10.1038/s41598-025-97974-5,https://pubmed.ncbi.nlm.nih.gov/40221607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,41844746,"Inflammatory, clinical and sociodemographic factors associated with depressive disorder during pregnancy in Brazilian women.",2026,10.1038/s41598-026-44447-y,https://pubmed.ncbi.nlm.nih.gov/41844746/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,42510549,A &lt;i&gt;Torilis japonica&lt;/i&gt; Extract-GHK-Cu Complex Attenuates Th2 Cytokines and Promotes Keratinocyte Recovery: A Potential Antioxidant Strategy for Atopic Dermatitis.,2026,10.3390/antiox15070818,https://pubmed.ncbi.nlm.nih.gov/42510549/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,41301909,Notable Differences in Clinical Features and Inflammatory Gene Expression Between Genital Lichen Sclerosus and Lichen Planus.,2025,10.3390/biomedicines13112817,https://pubmed.ncbi.nlm.nih.gov/41301909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,42229582,Temporal single-cell transcriptional dynamics of murine pancreatic islet remodeling during hyperglycaemia progression.,2026,10.1016/j.molmet.2026.102387,https://pubmed.ncbi.nlm.nih.gov/42229582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,40296873,Identification of characteristic genes in cutaneous squamous cell carcinoma based on weighted gene co-expression network analysis.,2025,10.3389/fgene.2025.1470584,https://pubmed.ncbi.nlm.nih.gov/40296873/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,40448127,A novel calreticulin of Psoroptes ovis regulated keratinocyte function resulting in host skin barrier dysfunction: implications for involvement in the pathogenesis of psoroptic mange.,2025,10.1186/s13071-025-06800-4,https://pubmed.ncbi.nlm.nih.gov/40448127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,42459939,"&lt;i&gt;Staphylococcus aureus&lt;/i&gt; aggravates psoriasis in human keratinocytes with the assistance of IL-17A and TNF- α, along with a contribution from genes associated with skin cutaneous melanoma.",2026,10.22099/mbrc.2025.54205.2207,https://pubmed.ncbi.nlm.nih.gov/42459939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,41614909,Chemokine Networks in Cutaneous T Cell Lymphoma: Tumor Microenvironment Remodeling and Therapeutic Targets.,2026,10.3390/cimb48010079,https://pubmed.ncbi.nlm.nih.gov/41614909/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,40181980,Harnessing immunotherapeutic molecules and diagnostic biomarkers as human-derived adjuvants for MERS-CoV vaccine development.,2025,10.3389/fimmu.2025.1538301,https://pubmed.ncbi.nlm.nih.gov/40181980/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,40269765,Pretreatment plasma sCD14 as a prognostic indicator in advanced non-small cell lung cancer patients undergoing immunotherapy.,2025,10.1186/s12885-025-14148-2,https://pubmed.ncbi.nlm.nih.gov/40269765/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,41920265,Glycyrrhizic Acid Alleviates Osimertinib-Induced Cutaneous Toxicity by Inhibiting Keratinocyte Apoptosis and Inflammation.,2026,10.1002/ptr.70310,https://pubmed.ncbi.nlm.nih.gov/41920265/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,41922257,[DDS Research Aimed at Optimizing Gene and Cell Therapies].,2026,10.1248/yakushi.25-00177,https://pubmed.ncbi.nlm.nih.gov/41922257/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,41451110,Inflammatory and fibrotic biomarkers in patients with atopic dermatitis treated with cendakimab.,2026,10.1016/j.jacig.2025.100609,https://pubmed.ncbi.nlm.nih.gov/41451110/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,39724768,Lipid nanoparticles encapsulating both adjuvant and antigen mRNA improve influenza immune cross-protection in mice.,2025,10.1016/j.biomaterials.2024.123039,https://pubmed.ncbi.nlm.nih.gov/39724768/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,39390542,Circulating levels of cytokines and risk of urologic cancers: a two-sample Mendelian randomization study.,2024,10.1186/s12885-024-13016-9,https://pubmed.ncbi.nlm.nih.gov/39390542/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,41357518,Comprehensive proteome profiling of molecular endotypes in Japanese adults with moderate-to-severe atopic dermatitis.,2025,10.3389/fmed.2025.1649918,https://pubmed.ncbi.nlm.nih.gov/41357518/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,41814865,Diagnostic concordance of dermatopathology and PCR in differentiating eczema from psoriasis.,2026,10.1111/jdv.70388,https://pubmed.ncbi.nlm.nih.gov/41814865/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCL27,ENSG00000213927,Unsafe,40409676,Systemic Inflammatory Markers Correlate with Chronic Kidney Disease-Associated Pruritus and Response to Treatment.,2026,10.1016/j.jid.2025.04.035,https://pubmed.ncbi.nlm.nih.gov/40409676/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,42880393,Modeling Progressive Pseudorheumatoid Arthropathy of Childhood: Disease Progression and Cartilage Pathology in CCN6 Knockout Sheep.,2026,10.1016/j.joca.2026.10.007,https://pubmed.ncbi.nlm.nih.gov/42880393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,41009407,Molecular Consequences of CCN6 Variants Encoding WISP3 in Progressive Pseudorheumatoid Dysplasia.,2025,10.3390/ijms26188838,https://pubmed.ncbi.nlm.nih.gov/41009407/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,42728239,Severe Phenotype in an Indian Family With Progressive Pseudorheumatoid Arthropathy of Childhood.,2026,10.1002/ajmg.a.70233,https://pubmed.ncbi.nlm.nih.gov/42728239/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,39950485,WISP3/CCN6 Adipocytokine Marker in Patients with Non-alcoholic Fatty Liver Disease (NAFLD) and its Association with Some Risk Factors.,2025,10.2174/0115680266334590241217065614,https://pubmed.ncbi.nlm.nih.gov/39950485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,40050813,Circulating CCN6/WISP3 in type 2 diabetes mellitus patients and its correlation with insulin resistance and inflammation: statistical and machine learning analyses.,2025,10.1186/s12911-025-02957-1,https://pubmed.ncbi.nlm.nih.gov/40050813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,42146788,The Role of the Cellular Communication Network Protein Family in Pulmonary Arterial Hypertension.,2026,10.1002/pul2.70323,https://pubmed.ncbi.nlm.nih.gov/42146788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,42560660,Transcriptomic comparison of the infrapatellar fat pad between young patients with traumatic knee injury and older patients with knee osteoarthritis.,2026,10.1080/03008207.2026.2712531,https://pubmed.ncbi.nlm.nih.gov/42560660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,41399379,WISP-3 facilitates CCL4-dependent monocyte migration and M1 polarization in rheumatoid arthritis by inhibiting miR-6894-5p.,2026,10.7150/ijms.122642,https://pubmed.ncbi.nlm.nih.gov/41399379/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,39024552,CCN6 Suppresses Metaplastic Breast Carcinoma by Antagonizing Wnt/β-Catenin Signaling to Inhibit EZH2-Driven EMT.,2024,10.1158/0008-5472.can-23-4054,https://pubmed.ncbi.nlm.nih.gov/39024552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,41721416,CCN3 as a moonlighting signaling protein: a potential model for dual nuclear and extracellular functions across the CCN family.,2026,10.1186/s12964-026-02746-x,https://pubmed.ncbi.nlm.nih.gov/41721416/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,40571215,WISP3 upregulates SDCBP expression to promote the progression of non-small cell lung cancer via the TGF-β signaling pathway.,2025,10.1016/j.bcp.2025.117082,https://pubmed.ncbi.nlm.nih.gov/40571215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,42256527,Species-specific roles of cellular communication network proteins in cartilage development: A comparative study using in vitro chondrogenic models.,2026,10.1002/ccs3.70089,https://pubmed.ncbi.nlm.nih.gov/42256527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,26610319,Progressive Pseudorheumatoid Dysplasia,1993,,https://pubmed.ncbi.nlm.nih.gov/26610319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,41262529,Identification and functional analysis of CCN6 variants in progressive pseudorheumatoid dysplasia: Exploring the potential role of ferroptosis and apoptosis in chondrocytes.,2026,10.1016/j.gendis.2025.101564,https://pubmed.ncbi.nlm.nih.gov/41262529/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,37608493,OTUB1 inhibits breast cancer by non-canonically stabilizing CCN6.,2023,10.1002/ctm2.1385,https://pubmed.ncbi.nlm.nih.gov/37608493/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,42349620,WISP-3 drives LUAD metastasis by suppressing miR-5004-5p to upregulate MMP-12.,2026,10.1016/j.bcp.2026.118189,https://pubmed.ncbi.nlm.nih.gov/42349620/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,37590989,Dual roles of cellular communication network factor 6 (CCN6) in the invasion and metastasis of oral cancer cells to bone via binding to BMP2 and RANKL.,2023,10.1093/carcin/bgad057,https://pubmed.ncbi.nlm.nih.gov/37590989/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,37195381,CCN proteins: opportunities for clinical studies-a personal perspective.,2023,10.1007/s12079-023-00761-y,https://pubmed.ncbi.nlm.nih.gov/37195381/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,39539552,Progressive pseudorheumatoid dysplasia involving a novel CCN6 mutation: a case report.,2024,10.3389/fimmu.2024.1445420,https://pubmed.ncbi.nlm.nih.gov/39539552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,34811632,The matricellular protein CCN6 differentially regulates mitochondrial metabolism in normal epithelium and in metaplastic breast carcinomas.,2022,10.1007/s12079-021-00657-9,https://pubmed.ncbi.nlm.nih.gov/34811632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,40807890,Noninvasive Mapping of Extracellular Potassium in Breast Tumors via Multi-Wavelength Photoacoustic Imaging.,2025,10.3390/s25154724,https://pubmed.ncbi.nlm.nih.gov/40807890/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,41358847,The Genetic Basis of Elongated Tails in Birds: Evidence for Sexual Selection as a Driver of Convergent Evolution.,2026,10.1111/1749-4877.70043,https://pubmed.ncbi.nlm.nih.gov/41358847/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,37468964,Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK/MAPK/ HIF-1α axis and activating wnt signaling pathway.,2023,10.1186/s40164-023-00419-w,https://pubmed.ncbi.nlm.nih.gov/37468964/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,30793395,Liver cancer: WISP3 suppresses hepatocellular carcinoma progression by negative regulation of β-catenin/TCF/LEF signalling.,2019,10.1111/cpr.12583,https://pubmed.ncbi.nlm.nih.gov/30793395/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,38268722,Construction of shared gene signature between rheumatoid arthritis and lung adenocarcinoma helps to predict the prognosis and tumor microenvironment of the LUAD patients.,2023,10.3389/fmolb.2023.1314753,https://pubmed.ncbi.nlm.nih.gov/38268722/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,31588320,Tumour suppression by targeted intravenous non-viral CRISPRa using dendritic polymers.,2019,10.1039/c9sc01432b,https://pubmed.ncbi.nlm.nih.gov/31588320/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,30075503,Ilizarov technique in an adolescent patient with progressive pseudorheumatoid dysplasia: A case report.,2018,10.1097/md.0000000000011375,https://pubmed.ncbi.nlm.nih.gov/30075503/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,34940056,Potential Role of CCN Proteins in Breast Cancer: Therapeutic Advances and Perspectives.,2021,10.3390/curroncol28060417,https://pubmed.ncbi.nlm.nih.gov/34940056/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,37202628,Significance of CCNs in liver regeneration.,2023,10.1007/s12079-023-00762-x,https://pubmed.ncbi.nlm.nih.gov/37202628/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,21525039,CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer.,2011,10.1242/jcs.084194,https://pubmed.ncbi.nlm.nih.gov/21525039/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,27829832,Members of the Cyr61/CTGF/NOV Protein Family: Emerging Players in Hepatic Progenitor Cell Activation and Intrahepatic Cholangiocarcinoma.,2016,10.1155/2016/2313850,https://pubmed.ncbi.nlm.nih.gov/27829832/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,34228239,CCN proteins in the musculoskeletal system: current understanding and challenges in physiology and pathology.,2021,10.1007/s12079-021-00631-5,https://pubmed.ncbi.nlm.nih.gov/34228239/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,27517291,CCN family of proteins: critical modulators of the tumor cell microenvironment.,2016,10.1007/s12079-016-0346-6,https://pubmed.ncbi.nlm.nih.gov/27517291/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,18568428,The CCN family of genes: a perspective on CCN biology and therapeutic potential.,2007,10.1007/s12079-008-0022-6,https://pubmed.ncbi.nlm.nih.gov/18568428/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,29411334,Regulation and bioactivity of the CCN family of genes and proteins in obesity and diabetes.,2018,10.1007/s12079-018-0458-2,https://pubmed.ncbi.nlm.nih.gov/29411334/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,22481923,Matricellular proteins: a sticky affair with cancers.,2012,10.1155/2012/351089,https://pubmed.ncbi.nlm.nih.gov/22481923/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,10471507,Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia.,1999,10.1038/12699,https://pubmed.ncbi.nlm.nih.gov/10471507/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCN6,ENSG00000112761,Unsafe,9843955,WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors.,1998,10.1073/pnas.95.25.14717,https://pubmed.ncbi.nlm.nih.gov/9843955/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,42524522,ALYREF-mediated m&lt;sup&gt;5&lt;/sup&gt;C modification of CCNA1 drives escape from cell-cycle arrest and contributes to pazopanib resistance in Renal Cell Carcinoma.,2026,10.7150/ijbs.131368,https://pubmed.ncbi.nlm.nih.gov/42524522/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,41871056,Elucidating the potential carcinogenic molecular mechanisms of parabens in head and neck squamous cell carcinoma through network toxicology and molecular docking.,2026,10.1371/journal.pone.0333867,https://pubmed.ncbi.nlm.nih.gov/41871056/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,41604083,Akt/mTOR pathway-mediated CCNA1 regulation of radiotherapy resistance in nasopharyngeal carcinoma.,2026,10.1007/s13402-026-01166-w,https://pubmed.ncbi.nlm.nih.gov/41604083/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,40722651,Molecular Markers for Thyroid Cancer Diagnosis: Insights from MAPK Pathway Gene Expression Analysis.,2025,10.3390/biomedicines13071577,https://pubmed.ncbi.nlm.nih.gov/40722651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,42482127,Feed restriction affects follicular development by regulating cell cycle progression in porcine mural granulosa cells.,2026,10.1186/s40104-026-01464-1,https://pubmed.ncbi.nlm.nih.gov/42482127/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,42469813,MRPL13 sustains mitochondrial integrity and MAPK-associated aggressiveness in esophageal squamous cell carcinoma.,2026,10.1186/s12935-026-04420-1,https://pubmed.ncbi.nlm.nih.gov/42469813/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,41126309,"Pathways in the brain, heart and lung influenced by SARS-CoV-2 NSP6 and SARS-CoV-2 regulated miRNAs: an in silico study hinting cancer incidence.",2025,10.1186/s40959-025-00387-6,https://pubmed.ncbi.nlm.nih.gov/41126309/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,42326385,HMMR as a robust prognostic biomarker correlates with immune infiltration and cell cycle pathways in oral squamous cell carcinoma: a multi-cohort bioinformatics analysis based on TCGA and GEO databases.,2026,10.3389/fgene.2026.1764943,https://pubmed.ncbi.nlm.nih.gov/42326385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,39734607,The Antioxidant and Anti-Inflammatory Impacts of Purple and White Eggplants on Fertility and Expression of Fertility-Related Genes in Rats Treated With Aluminum Chloride.,2024,10.1155/jt/8215321,https://pubmed.ncbi.nlm.nih.gov/39734607/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,41687753,Expression dynamics of sex-biased development- and immune-related genes are associated with early gonadal differentiation in grass carp.,2026,10.1016/j.fsi.2026.111201,https://pubmed.ncbi.nlm.nih.gov/41687753/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,42902153,Seasonal regulation of mRNAs and lncRNAs under cold exposure favours metabolic and immune-related pathways in Sahiwal Cattle.,2026,10.1186/s12864-026-13223-7,https://pubmed.ncbi.nlm.nih.gov/42902153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,41267139,SORCS2 serves as a tumor suppressor and associates with immune infiltration in ovarian cancer.,2025,10.1186/s13048-025-01822-z,https://pubmed.ncbi.nlm.nih.gov/41267139/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,37893043,Allyl Isothiocyanate Suppresses the Proliferation in Oral Squamous Cell Carcinoma via Mediating the KDM8/CCNA1 Axis.,2023,10.3390/biomedicines11102669,https://pubmed.ncbi.nlm.nih.gov/37893043/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,41154864,Research on the Mechanism of Hypoxia Tolerance of a Hybrid Fish Using Transcriptomics and Metabolomics.,2025,10.3390/biology14101462,https://pubmed.ncbi.nlm.nih.gov/41154864/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,41415563,"Farrerol inhibits proliferation and migration of colorectal cancer via the VEGF signaling pathway: evidence from network pharmacology, molecular docking, molecular dynamics simulation, and &lt;i&gt;in vitro&lt;/i&gt; experiments.",2025,10.3389/fphar.2025.1717293,https://pubmed.ncbi.nlm.nih.gov/41415563/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,38454404,Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming growth factor-beta (TGF-beta) pathway in osteoblasts.,2024,10.1186/s12891-024-07303-6,https://pubmed.ncbi.nlm.nih.gov/38454404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,41487287,Network-based insights into miR-30a-5p-mediated regulation and EGCG targeting in triple-negative breast cancer.,2025,10.3389/fbinf.2025.1735106,https://pubmed.ncbi.nlm.nih.gov/41487287/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,37904524,RNF6 promotes gastric cancer progression by regulating CCNA1/CREBBP transcription.,2023,10.1080/15384101.2023.2275899,https://pubmed.ncbi.nlm.nih.gov/37904524/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,40099461,Absence of pre-transplant T cell response against LAA is associated with Flt3-ITD mutation and increased relapse-risk in AML patients with HSCT.,2025,10.1080/1750743x.2025.2478804,https://pubmed.ncbi.nlm.nih.gov/40099461/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,38937666,Screening of potential hub genes involved in Kidney Wilms tumor via bioinformatics analysis and experimental validation.,2024,10.1186/s12885-024-12541-x,https://pubmed.ncbi.nlm.nih.gov/38937666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,36932973,Methylation Profile of Cancer Testis Antigens in Colorectal Cancer.,2023,10.22034/iji.2023.92600.2171,https://pubmed.ncbi.nlm.nih.gov/36932973/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,39588141,Role of Cellular Senescence Genes and Immune Infiltration in Sepsis and Sepsis-Induced ARDS Based on Bioinformatics Analysis.,2024,10.2147/jir.s488463,https://pubmed.ncbi.nlm.nih.gov/39588141/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,37684649,CD39 and LDHA affects the prognostic role of NLR in metastatic melanoma patients treated with immunotherapy.,2023,10.1186/s12967-023-04419-6,https://pubmed.ncbi.nlm.nih.gov/37684649/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,39262459,Comprehensive pan-cancer analysis reveals CDC6 as a potential immunomodulatory agent and promising therapeutic target in pancreatic cancer.,2024,10.21037/tcr-24-505,https://pubmed.ncbi.nlm.nih.gov/39262459/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,37805421,[Prognostic significance and immune cell infiltration analysis of differentially expressed genes in malignant pleural mesothelioma].,2023,10.3760/cma.j.cn121094-20220704-00352,https://pubmed.ncbi.nlm.nih.gov/37805421/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,40026477,Apoptosis and cell cycle arrest of bone marrow cells by green-synthesized silver but not albumin nanoparticles.,2025,10.1016/j.toxrep.2025.101960,https://pubmed.ncbi.nlm.nih.gov/40026477/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNA1,ENSG00000133101,Unsafe,9041194,Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines.,1997,,https://pubmed.ncbi.nlm.nih.gov/9041194/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,41009526,Investigating Germ Cell Transition Genes in Breast Cancer: Exploring the Genesis of Cancer Testis-Associated Markers.,2025,10.3390/ijms26188958,https://pubmed.ncbi.nlm.nih.gov/41009526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,41353334,Cyclin B2 facilitates glycolysis and tumor progression in pancreatic ductal adenocarcinoma by promoting histone lactylation.,2025,10.1186/s12885-025-15172-y,https://pubmed.ncbi.nlm.nih.gov/41353334/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,42106529,Identification of biomarkers associated with diagnosis of gastroesophageal junction adenocarcinoma and their correlation with immune infiltration.,2026,10.1007/s12672-026-05067-0,https://pubmed.ncbi.nlm.nih.gov/42106529/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,42500733,Delafloxacin suppresses DEPDC1 expression and induces G2/M arrest in non-small cell lung cancer cells: A drug repurposing study.,2026,10.1002/smo2.70050,https://pubmed.ncbi.nlm.nih.gov/42500733/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,42251782,Integrative single-cell and spatial transcriptomics analysis reveals a baicalein-responsive 10-gene signature for non-small cell lung cancer.,2026,10.1016/j.tranon.2026.102853,https://pubmed.ncbi.nlm.nih.gov/42251782/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,42515730,An Integrated Cellular Computational Pipeline Decodes Luteolin to Design Possible Allosteric CDK1/CYCLIN B1 Inhibitors That Overcome Breast Cancer Stemness.,2026,10.3390/ph19071048,https://pubmed.ncbi.nlm.nih.gov/42515730/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,42365339,Identification and validation of stemness-associated hub genes in cervical cancer: a bioinformatics and experimental study.,2026,10.1186/s12957-026-04472-7,https://pubmed.ncbi.nlm.nih.gov/42365339/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,41151687,"BUB1 and CCNB2 mediate cell cycle and inflammation, influencing the progression of oral squamous cell carcinoma.",2026,10.1016/j.jormas.2025.102630,https://pubmed.ncbi.nlm.nih.gov/41151687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,41612011,HNRNPF Increases MAF and CCNB2 Levels To Promote Cancer Cell Stemness and Progression of Pancreatic Ductal Adenocarcinoma.,2026,10.1007/s12015-026-11066-z,https://pubmed.ncbi.nlm.nih.gov/41612011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,39962178,Knockdown of CCNB2 inhibits the tumorigenesis of gastric cancer by regulation of the PI3K/Akt pathway.,2025,10.1038/s41598-025-89948-4,https://pubmed.ncbi.nlm.nih.gov/39962178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,42852766,"Identification and Functional Characterization of CDK1, CCNB1, CCNB2, RRM2, and GTSE1 Associated with Replicative Senescence of Human Umbilical Cord-Derived Mesenchymal Stem Cells.",2026,10.2174/011574888x508076260925100358,https://pubmed.ncbi.nlm.nih.gov/42852766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,40944462,Integrated bioinformatic and experimental study links cyclin B1/B2 to poor prognosis and immune infiltration in endometrial cancer.,2025,10.1080/01443615.2025.2551729,https://pubmed.ncbi.nlm.nih.gov/40944462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,40281940,Effect of Alternative Splicing Euchromatic Histone Lysine Methyltransferase 2 (&lt;i&gt;EHMT2/G9A&lt;/i&gt;) on Spermatogenesis in Mongolian Horses.,2025,10.3390/ani15081106,https://pubmed.ncbi.nlm.nih.gov/40281940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,41049007,Disulfidptosis-Associated CCNB2: A Prognostic Biomarker and Immune Microenvironment Modulator in Prostate Cancer.,2025,10.7150/jca.112791,https://pubmed.ncbi.nlm.nih.gov/41049007/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,41545643,Identification of hub genes and construction of a survival prediction model for patients with nasopharyngeal carcinoma.,2026,10.1038/s41598-026-36395-4,https://pubmed.ncbi.nlm.nih.gov/41545643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,42314223,Response of MRC-5 human lung fibroblasts to FLASH and conventional radiotherapy: A study on differential DNA damage and transcriptomic response.,2026,10.1016/j.compbiolchem.2026.109198,https://pubmed.ncbi.nlm.nih.gov/42314223/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,41284119,The analysis of TOP2A as a potential target for predicting the prognosis of brain glioma in the TCGA database and in single-center study.,2025,10.1007/s12672-025-04051-4,https://pubmed.ncbi.nlm.nih.gov/41284119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,41272619,Research on tracheal stenosis based on molecular biomarkers.,2025,10.1186/s12890-025-04034-9,https://pubmed.ncbi.nlm.nih.gov/41272619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,41337866,Molecular docking and dynamics reveal CCNB2 as a functional target of lncRNA ADAMTS9-AS1-002 in HNSCC.,2026,10.1016/j.bbrc.2025.153059,https://pubmed.ncbi.nlm.nih.gov/41337866/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,40629565,Identification of biomarkers and exploration of mechanisms for atopic dermatitis based on transcriptome and scRNA-seq data analysis.,2025,10.1097/md.0000000000042291,https://pubmed.ncbi.nlm.nih.gov/40629565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,42636674,Consensus subtypes and a generalizable prognostic signature defined by an R-loop score in hepatocellular carcinoma: Multi-omics analyses pinpoint KIF2A-positive proliferative tumor cells.,2026,10.1016/j.prp.2026.156656,https://pubmed.ncbi.nlm.nih.gov/42636674/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,42592322,A six-gene prognostic signature for aflatoxin B1-associated hepatocellular carcinoma identified through integrated bioinformatics and network toxicology.,2026,10.21037/tgh-2026-0053,https://pubmed.ncbi.nlm.nih.gov/42592322/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,41871056,Elucidating the potential carcinogenic molecular mechanisms of parabens in head and neck squamous cell carcinoma through network toxicology and molecular docking.,2026,10.1371/journal.pone.0333867,https://pubmed.ncbi.nlm.nih.gov/41871056/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,38831807,High expression of CCNB2 is an independent predictive poor prognostic biomarker and correlates with immune infiltrates in breast carcinoma.,2024,10.1016/j.heliyon.2024.e31586,https://pubmed.ncbi.nlm.nih.gov/38831807/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,41056367,In-silico identification of host-key-genes associated with dengue-virus-infections highlighting their pathogenetic mechanisms and therapeutic agents.,2025,10.1371/journal.pone.0333509,https://pubmed.ncbi.nlm.nih.gov/41056367/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,41858177,Pedunculoside Inhibits Hepatocellular Carcinoma Progression by Activating the MAPK Signaling Pathway Through Targeting and Suppressing CDK4.,2026,10.1002/ptr.70308,https://pubmed.ncbi.nlm.nih.gov/41858177/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,40390492,Identification of key biomarker genes in liver hepatocellular carcinoma and kidney renal clear cell carcinoma progression: A shared high-throughput screening and molecular docking method with potentials for targeted therapeutic interventions.,2025,10.1016/j.jgeb.2025.100497,https://pubmed.ncbi.nlm.nih.gov/40390492/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,40496041,Clinical significance of cyclin-dependent kinase inhibitor 3 in hepatocellular carcinoma.,2025,10.3892/mco.2025.2860,https://pubmed.ncbi.nlm.nih.gov/40496041/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,38300330,Upregulation of CCNB2 and a novel lncRNAs-related risk model predict prognosis in clear cell renal cell carcinoma.,2024,10.1007/s00432-024-05611-x,https://pubmed.ncbi.nlm.nih.gov/38300330/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,41803949,SMC4/SMAD3/NF-κB axis drives cervical cancer progression and radioresistance via DNA damage repair and immune modulation.,2026,10.1186/s12967-026-07979-5,https://pubmed.ncbi.nlm.nih.gov/41803949/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,41327255,Decoding cross-talk between Mpox and HIV: insights from transcriptomics and network-based analyses.,2025,10.1186/s12985-025-03026-9,https://pubmed.ncbi.nlm.nih.gov/41327255/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB2,ENSG00000157456,Unsafe,39528802,Discovery of key molecular signatures for diagnosis and therapies of glioblastoma by combining supervised and unsupervised learning approaches.,2024,10.1038/s41598-024-79391-2,https://pubmed.ncbi.nlm.nih.gov/39528802/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,41874418,Cyclin B3 dsRNA Orchestrate Meiotic Progression in Porcine Oocytes.,2026,10.1093/jmcb/mjag014,https://pubmed.ncbi.nlm.nih.gov/41874418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,42358528,BCOR-CCNB3 fusion-positive sarcoma treated with chemotherapy and carbon-ion radiotherapy: a case report of long-term disease control of a cervical spine case with a 12-year follow-up.,2026,10.3389/fonc.2026.1869278,https://pubmed.ncbi.nlm.nih.gov/42358528/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,41153330,CCNA2 and CCNB3 as Early Potential Molecular Candidates of Oocyte Maturation in Cumulus-Oophorous Complex Cells from Follicular Fluid.,2025,10.3390/diagnostics15202658,https://pubmed.ncbi.nlm.nih.gov/41153330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,42393067,A single-cell atlas of alternative wing development in two hemipteran species.,2026,10.1038/s41467-026-75225-z,https://pubmed.ncbi.nlm.nih.gov/42393067/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,37238135,RNAi Analysis of Potential Functions of Cyclin B3 in Reproduction of Male Oriental River Prawns (Macrobrachium nipponense).,2023,10.3390/ani13101703,https://pubmed.ncbi.nlm.nih.gov/37238135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,40652565,Update on the management of BCOR::CCNB3 sarcoma.,2025,10.1093/jjco/hyaf111,https://pubmed.ncbi.nlm.nih.gov/40652565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,40932977,BCOR::CCNB3 Sarcoma of the Thigh: A Rare Case.,2025,10.7759/cureus.89654,https://pubmed.ncbi.nlm.nih.gov/40932977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,42345812,Two-Step &lt;i&gt;Vibrio parahaemolyticus&lt;/i&gt; Challenge Reveals Transcriptional Reprogramming of Trained Immunity in Shrimp Hemocytes.,2026,10.3390/biology15120956,https://pubmed.ncbi.nlm.nih.gov/42345812/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,41735791,Primary Adrenal BCOR::CCNB3 Sarcoma: Fine Needle Aspiration Cytology Findings.,2026,10.1002/dc.70107,https://pubmed.ncbi.nlm.nih.gov/41735791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,40500922,Unveiling Diagnostic Clues of BCOR-CCNB3 Sarcoma in Fine-Needle Aspiration Specimens.,2025,10.1111/cyt.70000,https://pubmed.ncbi.nlm.nih.gov/40500922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,40298239,"The Extensive Case Series of 21 CIC::DUX4 , 18 BCOR::CCNB3 and 148 Ewing's Sarcomas From a Single Center.",2025,10.1097/pas.0000000000002403,https://pubmed.ncbi.nlm.nih.gov/40298239/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,42800358,Time-resolved transcriptomics reveals sex-specific programs of gametogenesis and post-spawning gonadal remodeling in the sea cucumber Apostichopus japonicus.,2026,10.1016/j.cbd.2026.102025,https://pubmed.ncbi.nlm.nih.gov/42800358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,42301382,Network Pharmacology-Based Identification of Potential Targets and Mechanisms of Isoginkgetin in Gastric Cancer.,2026,10.1155/bmri/8863892,https://pubmed.ncbi.nlm.nih.gov/42301382/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,42653206,Next-Generation Sequencing Refines Diagnosis and Expands Precision Medicine Opportunities in Soft Tissue Sarcomas.,2026,10.3390/ijms27167201,https://pubmed.ncbi.nlm.nih.gov/42653206/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,41913417,Morphological and molecular characterization of skeletal and extraskeletal Ewing family of tumors in a tertiary care center of eastern India.,2026,10.4103/ijpm.ijpm_256_25,https://pubmed.ncbi.nlm.nih.gov/41913417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,41643728,Pediatric Sarcomas With BCOR and CIC Aberrations: Advanced Diagnosis and Treatment Outcomes.,2026,10.5858/arpa.2025-0055-oa,https://pubmed.ncbi.nlm.nih.gov/41643728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,39815746,Primary renal BCOR::CCNB3 sarcoma in a female patient: case report.,2025,10.4132/jptm.2024.09.30,https://pubmed.ncbi.nlm.nih.gov/39815746/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,39871307,"Development, optimization and application of a universal fluorescence multiplex PCR-based assay to detect BCOR genetic alterations in pediatric tumors.",2025,10.1186/s13000-025-01604-7,https://pubmed.ncbi.nlm.nih.gov/39871307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,41494974,"Undifferentiated Round Cell Sarcomas: Retrospective Morphological, Immunohistochemical, and Molecular Re-Evaluation Including a Unique Case of ZC3H7B::BCOR Fusion.",2026,10.1111/apm.70128,https://pubmed.ncbi.nlm.nih.gov/41494974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,37635245,Mutations in CCNB3 affect its location thus causing a multiplicity of phenotypes in human oocytes maturation by aberrant CDK1 activity and APC/C activity at different stages.,2023,10.1186/s13048-023-01229-8,https://pubmed.ncbi.nlm.nih.gov/37635245/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,36915189,Rare Case of BCOR::CCNB3 Sarcoma of Bone.,2023,10.12659/ajcr.938158,https://pubmed.ncbi.nlm.nih.gov/36915189/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,36791667,"A global collaboRAtive study of CIC-rearranged, BCOR::CCNB3-rearranged and other ultra-rare unclassified undifferentiated small round cell sarcomas (GRACefUl).",2023,10.1016/j.ejca.2023.01.003,https://pubmed.ncbi.nlm.nih.gov/36791667/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,35568949,BCOR-CCNB3 sarcoma with concurrent RNF213-SLC26A11 gene fusion: a rare sarcoma with altered histopathological features after chemotherapy.,2022,10.1186/s12957-022-02611-4,https://pubmed.ncbi.nlm.nih.gov/35568949/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,38544655,When Sarcomas Mimic Lymphomas: A BCOR-Rearranged Sarcoma Case Report.,2024,10.7759/cureus.54944,https://pubmed.ncbi.nlm.nih.gov/38544655/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,39188951,Systematic bioinformatics analysis reveals the role of shikonin in blocking colon cancer progression by identifying senescence-induced genes.,2024,10.3389/fphar.2024.1360587,https://pubmed.ncbi.nlm.nih.gov/39188951/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,34819304,Clinicopathologic and molecular analysis of a BCOR-CCNB3 undifferentiated sarcoma of the kidney reveals significant epigenetic alterations.,2022,10.1101/mcs.a005942,https://pubmed.ncbi.nlm.nih.gov/34819304/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,32871837,A Case Series of BCOR Sarcomas With a New Splice Variant of BCOR/CCNB3 Fusion Gene.,2020,10.21873/invivo.12125,https://pubmed.ncbi.nlm.nih.gov/32871837/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,32923894,Sustained Complete Response to Palbociclib in a Refractory Pediatric Sarcoma With BCOR-CCNB3 Fusion and Germline CDKN2B Variant.,2020,10.1200/po.19.00258,https://pubmed.ncbi.nlm.nih.gov/32923894/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,36706311,Strategies for the Treatment of Infantile Soft Tissue Sarcomas With BCOR Alterations.,2023,10.1097/mph.0000000000002620,https://pubmed.ncbi.nlm.nih.gov/36706311/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,35628146,Impact of Environmentally Relevant Concentrations of Bisphenol A (BPA) on the Gene Expression Profile in an In Vitro Model of the Normal Human Ovary.,2022,10.3390/ijms23105334,https://pubmed.ncbi.nlm.nih.gov/35628146/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,33488267,Survey of Paediatric Oncologists and Pathologists regarding Their Views and Experiences with Variant Translocations in Ewing and Ewing-Like Sarcoma: A Report of the Children's Oncology Group.,2020,10.1155/2020/3498549,https://pubmed.ncbi.nlm.nih.gov/33488267/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,34791246,Whole-exome sequencing of a cohort of infertile men reveals novel causative genes in teratozoospermia that are chiefly related to sperm head defects.,2021,10.1093/humrep/deab229,https://pubmed.ncbi.nlm.nih.gov/34791246/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,32034283,NTRK3 overexpression in undifferentiated sarcomas with YWHAE and BCOR genetic alterations.,2020,10.1038/s41379-020-0495-2,https://pubmed.ncbi.nlm.nih.gov/32034283/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,31150281,BCOR involvement in cancer.,2019,10.2217/epi-2018-0195,https://pubmed.ncbi.nlm.nih.gov/31150281/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,31013298,Structural and diffusion weighted MRI demonstrates responses to ibrutinib in a mouse model of follicular helper (Tfh) T-cell lymphoma.,2019,10.1371/journal.pone.0215765,https://pubmed.ncbi.nlm.nih.gov/31013298/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,12185076,"Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin.",2002,10.1074/jbc.m203951200,https://pubmed.ncbi.nlm.nih.gov/12185076/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNB3,ENSG00000147082,Unsafe,11846420,"Molecular cloning, gene localization, and structure of human cyclin B3.",2002,10.1006/bbrc.2002.6458,https://pubmed.ncbi.nlm.nih.gov/11846420/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,40723419,Functional Analysis of the Cyclin E Gene in the Reproductive Development of Rainbow Trout (&lt;i&gt;Oncorhynchus mykiss&lt;/i&gt;).,2025,10.3390/biology14070862,https://pubmed.ncbi.nlm.nih.gov/40723419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,42665132,Endocrine disrupting effects of estrone on male Siniperca chuatsi: From gonadal remodeling to gene regulation.,2027,10.1016/j.jsbmb.2026.107107,https://pubmed.ncbi.nlm.nih.gov/42665132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,40269062,CCNE2 promotes cisplatin resistance and affects prognosis of head and neck squamous cell carcinoma by targeting MNAT1.,2025,10.1038/s41598-025-98989-8,https://pubmed.ncbi.nlm.nih.gov/40269062/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,40820921,Targeting CCNE2 to alleviate rheumatoid arthritis through inducing senescence and apoptosis.,2026,10.1093/mr/roaf077,https://pubmed.ncbi.nlm.nih.gov/40820921/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,42658569,DIXDC1 Promotes Lymphatic Metastasis and Resistance to Cuproptosis in Bladder Cancer Through Mediating DLAT.,2026,10.1002/advs.77435,https://pubmed.ncbi.nlm.nih.gov/42658569/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,41157796,MiR-30a-5p Regulates the Proliferation of Wilms Tumor Cells Through CyclinE2.,2026,10.1111/iju.70270,https://pubmed.ncbi.nlm.nih.gov/41157796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,41653653,OSMR coordinates a self-perpetuating circuit linking chemoresistance and neutrophil-driven immunosuppression in gastric cancer.,2026,10.1016/j.neo.2026.101279,https://pubmed.ncbi.nlm.nih.gov/41653653/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,42482127,Feed restriction affects follicular development by regulating cell cycle progression in porcine mural granulosa cells.,2026,10.1186/s40104-026-01464-1,https://pubmed.ncbi.nlm.nih.gov/42482127/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,42646930,Long-Term Oral Exposure to Chlorophenylacetonitrile Induces Gastrointestinal Morphological Alterations and Splenic Transcriptomic Reprogramming in Mice.,2026,10.3390/toxics14080647,https://pubmed.ncbi.nlm.nih.gov/42646930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,42303079,Orientin inhibits cyclin E/cyclin A-CDK2 to induce growth arrest at senescence in human gastric cancer cells.,2026,10.1016/j.fct.2026.116227,https://pubmed.ncbi.nlm.nih.gov/42303079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,39572025,ELF3 Overexpression Contributes to the Malignant Transformation of HPV16 E6/E7-Immortalized Keratinocytes by Promoting CCNE2 Expression.,2024,10.4014/jmb.2408.08041,https://pubmed.ncbi.nlm.nih.gov/39572025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,41431399,Interaction between ZMIZ2 and AR promotes prostate cancer proliferation in vitro and in vivo.,2026,10.1080/15384047.2025.2604936,https://pubmed.ncbi.nlm.nih.gov/41431399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,41555212,Transcriptome analysis reveals KRAS as a crucial regulator of ovarian follicle development in Wuding chickens.,2026,10.1186/s12864-026-12546-9,https://pubmed.ncbi.nlm.nih.gov/41555212/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,40697521,Identification of genes associated with hepatitis B virus infection and breast cancer tumorigenesis and progression.,2025,10.1016/j.bbrep.2025.102156,https://pubmed.ncbi.nlm.nih.gov/40697521/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,42421776,Self-organizing three-dimensional dermal papilla cell spheroids yield therapeutic extracellular vesicles that target hypertrophic scar regression via the miR-26a-5p/CCNE2 axis.,2026,10.1093/burnst/tkaf048,https://pubmed.ncbi.nlm.nih.gov/42421776/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,38928079,The Role of Z Chromosome Localization Gene psmd9 in Spermatogenesis of Cynoglossus semilaevis.,2024,10.3390/ijms25126372,https://pubmed.ncbi.nlm.nih.gov/38928079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,40428395,Olig1/2 Drive Astrocytic Glioblastoma Proliferation Through Transcriptional Co-Regulation of Various Cyclins.,2025,10.3390/genes16050573,https://pubmed.ncbi.nlm.nih.gov/40428395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,39513205,Comprehensive cataloging of miR-363 as a therapeutic &amp; non-invasive biomarker of prostate cancer.,2024,10.25259/ijmr_2274_23,https://pubmed.ncbi.nlm.nih.gov/39513205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,39839747,SOX2 control activation of dormant prostate cancer cells in bone metastases by promoting CCNE2 gene expression.,2024,10.62347/ascy2532,https://pubmed.ncbi.nlm.nih.gov/39839747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,38238463,Regnase-2 inhibits glioblastoma cell proliferation.,2024,10.1038/s41598-024-51809-x,https://pubmed.ncbi.nlm.nih.gov/38238463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,39469865,Targeting CDK2 to combat drug resistance in cancer therapy.,2024,10.1080/14796694.2024.2416382,https://pubmed.ncbi.nlm.nih.gov/39469865/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,40850114,Spatial transcriptomics unravels the interactive network of aflatoxin B1-driven gastric cancer: Multi-omics integration of transcriptome and mendelian randomization.,2025,10.1016/j.ecoenv.2025.118919,https://pubmed.ncbi.nlm.nih.gov/40850114/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,38515149,CircHAS2 activates CCNE2 to promote cell proliferation and sensitizes the response of colorectal cancer to anlotinib.,2024,10.1186/s12943-024-01971-7,https://pubmed.ncbi.nlm.nih.gov/38515149/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,40675964,Heat shock factor 1 promotes proliferation and chemoresistance in diffuse large B-cell lymphoma by enhancing the cell cycle and DNA repair.,2025,10.1038/s41419-025-07843-2,https://pubmed.ncbi.nlm.nih.gov/40675964/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,40679709,Phosphoenolpyruvate carboxykinase 2 (PCK2) attenuates bovine adipocyte lipolysis through PNPLA2 activity repression.,2025,10.1007/s10142-025-01666-2,https://pubmed.ncbi.nlm.nih.gov/40679709/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,40682616,"Royal Jelly Enhances the Sensitivity of Oral Squamous Cancer Cells to Paclitaxel, Suppressing Proliferation, Migration, and Glycolysis.",2025,10.1007/s12013-025-01834-y,https://pubmed.ncbi.nlm.nih.gov/40682616/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,40753072,CDK inhibitors promote neuroblastoma cell differentiation and increase sensitivity to retinoic acid-a promising combination strategy for therapeutic intervention.,2025,10.1038/s41420-025-02637-z,https://pubmed.ncbi.nlm.nih.gov/40753072/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,40434346,Clofarabine Enhances the Transduction Efficiency of Recombinant AAV2 in the Retina.,2025,10.1167/iovs.66.5.42,https://pubmed.ncbi.nlm.nih.gov/40434346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,38643462,Integrative analysis based on the cell cycle-related genes identifies TPX2 as a novel prognostic biomarker associated with tumor immunity in breast cancer.,2024,10.18632/aging.205752,https://pubmed.ncbi.nlm.nih.gov/38643462/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,40338807,Exploring the Mechanisms of Microenergy Acoustic Pulse Therapy for the Treatment of Female Stress Urinary Incontinence-Part II.,2025,10.1002/nau.70048,https://pubmed.ncbi.nlm.nih.gov/40338807/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,38901667,FOXK2 amplification promotes breast cancer development and chemoresistance.,2024,10.1016/j.canlet.2024.217074,https://pubmed.ncbi.nlm.nih.gov/38901667/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,40686981,"Ruthenium(II) Complex with 3,4-Methylenedioxy Cinnamic Acid Induces Cell Cycle Arrest at G0/G1 and Apoptosis via ROS Generation and Bioenergetics Disruption in Non-Small Cell Lung Cancer Cells.",2025,10.1021/acsomega.5c00526,https://pubmed.ncbi.nlm.nih.gov/40686981/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,38981878,Study of sex-biased differences in genomic profiles in East Asian hepatocellular carcinoma.,2024,10.1007/s12672-024-01131-9,https://pubmed.ncbi.nlm.nih.gov/38981878/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,9858585,"Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers.",1999,10.1128/mcb.19.1.612,https://pubmed.ncbi.nlm.nih.gov/9858585/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,9840943,"Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins.",1998,10.1038/sj.onc.1202505,https://pubmed.ncbi.nlm.nih.gov/9840943/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCNE2,ENSG00000175305,Unsafe,9840927,Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle.,1998,10.1038/sj.onc.1202477,https://pubmed.ncbi.nlm.nih.gov/9840927/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,42824135,Identification of &lt;i&gt;CCSER1&lt;/i&gt; missense variants and diplotypes as molecular markers for growth and lambing-related traits in Junken meat sheep.,2026,10.3389/fvets.2026.1922937,https://pubmed.ncbi.nlm.nih.gov/42824135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,41792401,A radio-genomics biomarker for precision epidermal growth factor receptor mutation targeting therapy in non-small cell lung cancer.,2026,10.1038/s41598-026-42948-4,https://pubmed.ncbi.nlm.nih.gov/41792401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,38814547,Discovery of core genes and intercellular communication role in osteosarcoma.,2025,10.1007/s13353-024-00872-1,https://pubmed.ncbi.nlm.nih.gov/38814547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,38231770,Polymorphisms of CCSER1 Gene and Their Correlation with Milk Quality Traits in Gannan Yak (Bos grunniens).,2023,10.3390/foods12234318,https://pubmed.ncbi.nlm.nih.gov/38231770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,42450064,Genomic Variability of the HCT116 Cell Line Identified Using Oxford Nanopore Sequencing.,2026,10.3390/ijms27135791,https://pubmed.ncbi.nlm.nih.gov/42450064/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,41300409,Study on the Genomic Basis of Adaptation in Salsk Sheep.,2025,10.3390/biology14111620,https://pubmed.ncbi.nlm.nih.gov/41300409/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,41408150,Claudin and Rab proteins are key molecular components involved in coccidiosis resistance in Portuguese Merino sheep.,2025,10.1186/s12711-025-01020-x,https://pubmed.ncbi.nlm.nih.gov/41408150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,37570259,Genomic Prediction and Genome-Wide Association Study for Boar Taint Compounds.,2023,10.3390/ani13152450,https://pubmed.ncbi.nlm.nih.gov/37570259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,38872797,Genome-wide association analysis of fleece traits in Northwest Xizang white cashmere goat.,2024,10.3389/fvets.2024.1409084,https://pubmed.ncbi.nlm.nih.gov/38872797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,39643897,"Examination of homozygosity runs and selection signatures in native goat breeds of Henan, China.",2024,10.1186/s12864-024-11098-0,https://pubmed.ncbi.nlm.nih.gov/39643897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,38998095,Genome-Wide Association Study for Weight Loss at the End of Dry-Curing of Hams Produced from Purebred Heavy Pigs.,2024,10.3390/ani14131983,https://pubmed.ncbi.nlm.nih.gov/38998095/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,34187875,Deletion of a pseudogene within a fragile site triggers the oncogenic expression of the mitotic CCSER1 gene.,2021,10.26508/lsa.202101019,https://pubmed.ncbi.nlm.nih.gov/34187875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,35108172,Association between the copy number variation of CCSER1 gene and growth traits in Chinese Capra hircus (goat) populations.,2023,10.1080/10495398.2022.2025818,https://pubmed.ncbi.nlm.nih.gov/35108172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,41120831,A comprehensive genome-wide analysis for signatures of selection in goat (genus Capra) revealed new candidate genes for environmental adaptation and productive traits.,2025,10.1186/s12864-025-12133-4,https://pubmed.ncbi.nlm.nih.gov/41120831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,39766904,Genome-Wide Association Analysis of Growth Traits in Hu Sheep.,2024,10.3390/genes15121637,https://pubmed.ncbi.nlm.nih.gov/39766904/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,36187126,Association between lncRNAs in plasma exosomes and diabetic retinopathy.,2022,10.3389/fendo.2022.987488,https://pubmed.ncbi.nlm.nih.gov/36187126/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,23665203,FAM190A deficiency creates a cell division defect.,2013,10.1016/j.ajpath.2013.03.020,https://pubmed.ncbi.nlm.nih.gov/23665203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,35229935,Contingent stimulus delivery assay for zebrafish reveals a role for CCSER1 in alcohol preference.,2022,10.1111/adb.13126,https://pubmed.ncbi.nlm.nih.gov/35229935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,38998043,"Genomic Characterization of Local Croatian Sheep Breeds-Effective Population Size, Inbreeding & Signatures of Selection.",2024,10.3390/ani14131928,https://pubmed.ncbi.nlm.nih.gov/38998043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,30298359,Functional evaluation of alternative splicing in the FAM190A gene.,2019,10.1007/s13258-018-0752-7,https://pubmed.ncbi.nlm.nih.gov/30298359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,38544805,Comprehensive whole-genome resequencing unveils genetic diversity and selective signatures of the Xiangdong black goat.,2024,10.3389/fgene.2024.1326828,https://pubmed.ncbi.nlm.nih.gov/38544805/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,34141453,DNA methylation at birth potentially mediates the association between prenatal lead (Pb) exposure and infant neurodevelopmental outcomes.,2021,10.1093/eep/dvab005,https://pubmed.ncbi.nlm.nih.gov/34141453/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,34601942,Genome-Wide Association Study of Peripheral Artery Disease.,2021,10.1161/circgen.119.002862,https://pubmed.ncbi.nlm.nih.gov/34601942/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCSER1,ENSG00000184305,Unsafe,26083354,Genome-Wide Specific Selection in Three Domestic Sheep Breeds.,2015,10.1371/journal.pone.0128688,https://pubmed.ncbi.nlm.nih.gov/26083354/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT6B,ENSG00000132141,Unsafe,42624177,CCT6B as a candidate chaperonin-related molecule in hepatocellular carcinoma: Bioinformatic analysis and preliminary experimental validation.,2026,10.1016/j.gene.2026.150364,https://pubmed.ncbi.nlm.nih.gov/42624177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT6B,ENSG00000132141,Unsafe,41312091,Chaperonins in Hepatocellular Carcinoma: Unveiling Their Role in Tumor Proliferation and Immune Modulation Through Multiomics Analysis.,2025,10.1155/ijog/6152675,https://pubmed.ncbi.nlm.nih.gov/41312091/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT6B,ENSG00000132141,Unsafe,39948392,Molecular mechanisms of lung injury from ultra high and conventional dose rate pulsed radiation based on 4D DIA proteomics study.,2025,10.1038/s41598-025-87247-6,https://pubmed.ncbi.nlm.nih.gov/39948392/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT6B,ENSG00000132141,Unsafe,35011680,Combined Use of Whole Exome Sequencing and CRISPR/Cas9 to Study the Etiology of Non-Obstructive Azoospermia: Demonstration of the Dispensable Role of the Testis-Specific Genes C1orf185 and CCT6B.,2021,10.3390/cells11010118,https://pubmed.ncbi.nlm.nih.gov/35011680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT6B,ENSG00000132141,Unsafe,34141486,T-complex protein 1 subunit zeta-2 (CCT6B) deficiency induces murine teratospermia.,2021,10.7717/peerj.11545,https://pubmed.ncbi.nlm.nih.gov/34141486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT6B,ENSG00000132141,Unsafe,34820261,Eosinophilia characterized by a rare CCT6B mutation and responsive to tyrosine kinase inhibition: Case report and literature review.,2021,10.1016/j.lrr.2021.100279,https://pubmed.ncbi.nlm.nih.gov/34820261/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT6B,ENSG00000132141,Unsafe,36299463,Proteomics analysis of cancer tissues identifies IGF2R as a potential therapeutic target in laryngeal carcinoma.,2022,10.3389/fendo.2022.1031210,https://pubmed.ncbi.nlm.nih.gov/36299463/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT6B,ENSG00000132141,Unsafe,33815471,Systematic Characterization of Expression Profiles and Prognostic Values of the Eight Subunits of the Chaperonin TRiC in Breast Cancer.,2021,10.3389/fgene.2021.637887,https://pubmed.ncbi.nlm.nih.gov/33815471/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT6B,ENSG00000132141,Unsafe,33897772,Prognostic Power of a Chaperonin Containing TCP-1 Subunit Genes Panel for Hepatocellular Carcinoma.,2021,10.3389/fgene.2021.668871,https://pubmed.ncbi.nlm.nih.gov/33897772/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT6B,ENSG00000132141,Unsafe,32650378,Distinct Proteomic Profile of Spermatozoa from Men with Seminomatous and Non-Seminomatous Testicular Germ Cell Tumors.,2020,10.3390/ijms21144817,https://pubmed.ncbi.nlm.nih.gov/32650378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT6B,ENSG00000132141,Unsafe,31072365,Overexpression of chaperonin containing T-complex polypeptide subunit zeta 2 (CCT6b) suppresses the functions of active fibroblasts in a rat model of joint contracture.,2019,10.1186/s13018-019-1161-6,https://pubmed.ncbi.nlm.nih.gov/31072365/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT6B,ENSG00000132141,Unsafe,33869000,Molecular and Clinical Characterization of CCT2 Expression and Prognosis via Large-Scale Transcriptome Profile of Breast Cancer.,2021,10.3389/fonc.2021.614497,https://pubmed.ncbi.nlm.nih.gov/33869000/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT6B,ENSG00000132141,Unsafe,31934176,The TCP1 ring complex is associated with malignancy and poor prognosis in hepatocellular carcinoma.,2019,,https://pubmed.ncbi.nlm.nih.gov/31934176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT6B,ENSG00000132141,Unsafe,26732106,Proteomic signatures of infertile men with clinical varicocele and their validation studies reveal mitochondrial dysfunction leading to infertility.,2016,10.4103/1008-682x.170445,https://pubmed.ncbi.nlm.nih.gov/26732106/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT6B,ENSG00000132141,Unsafe,23143597,The genetic landscape of mutations in Burkitt lymphoma.,2012,10.1038/ng.2468,https://pubmed.ncbi.nlm.nih.gov/23143597/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT6B,ENSG00000132141,Unsafe,15657744,"Differential gene expression in yellow-necked mice Apodemus flavicollis (Rodentia, Mammalia) with and without B chromosomes.",2005,10.1007/s00412-004-0327-z,https://pubmed.ncbi.nlm.nih.gov/15657744/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CCT6B,ENSG00000132141,Unsafe,8812458,"Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method.",1996,10.1006/geno.1996.0467,https://pubmed.ncbi.nlm.nih.gov/8812458/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,42903866,Genetic tool for specific tracking of mature neutrophils.,2026,10.1016/j.hlife.2026.05.007,https://pubmed.ncbi.nlm.nih.gov/42903866/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,42724782,Integrative analysis of single-cell sequencing identifies CD8&lt;sup&gt;+&lt;/sup&gt; TIM3&lt;sup&gt;+&lt;/sup&gt; CD101&lt;sup&gt;+&lt;/sup&gt; T cell-associated genes as prognostic biomarkers in breast cancer.,2026,10.21037/tcr-2026-0674,https://pubmed.ncbi.nlm.nih.gov/42724782/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,42283579,Expansion of CD101⁻ neutrophils drives susceptibility to hyperyersiniabactin-producing &lt;i&gt;Yersinia&lt;/i&gt; infection in hereditary hemochromatotic hosts.,2026,10.1128/iai.00691-25,https://pubmed.ncbi.nlm.nih.gov/42283579/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,41493025,CD101: A versatile molecule associated with immunoregulatory and antimicrobial functions.,2026,10.1093/jleuko/qiaf189,https://pubmed.ncbi.nlm.nih.gov/41493025/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,42019709,SiglecF-expressing neutrophils differentiate from mature neutrophils locally in the heart after myocardial infarction.,2026,10.1016/j.exphem.2026.105429,https://pubmed.ncbi.nlm.nih.gov/42019709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,42458727,Causal Insights Into Crohn's Disease: The Role of Oxidative Stress and Genetic Variants.,2026,10.1111/jcmm.71257,https://pubmed.ncbi.nlm.nih.gov/42458727/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,40950889,The diagnostic value of CD101 in smear-negative pulmonary tuberculosis.,2025,10.21037/jtd-2025-1299,https://pubmed.ncbi.nlm.nih.gov/40950889/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,41495843,"M2 macrophages modulate the differentiation of CD8 + CD101-TIM3 + T cells via the SPP1‒CD44 pathway, influencing the immunotherapeutic response in NSCLC.",2026,10.1186/s12967-025-07662-1,https://pubmed.ncbi.nlm.nih.gov/41495843/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,42534761,Human epidermal resident memory T cells: beyond the dermal perspective.,2026,10.3389/fimmu.2026.1903376,https://pubmed.ncbi.nlm.nih.gov/42534761/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,42222594,Circulating eosinophils in patients with hypereosinophilic syndrome have heterogeneous immunophenotypes.,2026,10.1016/j.jacig.2026.100722,https://pubmed.ncbi.nlm.nih.gov/42222594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,41674942,Integrated single-cell and transcriptomic analysis of CD8&lt;sup&gt;+&lt;/sup&gt;CD101&lt;sup&gt;+&lt;/sup&gt;TIM3&lt;sup&gt;+&lt;/sup&gt; T cells in hepatocellular carcinoma: implications for tumor microenvironment and prognostic modeling.,2026,10.21037/tcr-2025-1639,https://pubmed.ncbi.nlm.nih.gov/41674942/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,41117802,Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance.,2026,10.1084/jem.20251635,https://pubmed.ncbi.nlm.nih.gov/41117802/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,42100993,The Secretome of Bullous Pemphigoid IgG-Treated Keratinocytes Induces a Pro-Inflammatory Eosinophil Response.,2026,10.1111/exd.70265,https://pubmed.ncbi.nlm.nih.gov/42100993/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,42510671,Analysis of Colon Transcriptomes in a Porcine Model of Dextran Sodium Sulfate (DSS)-Induced Ulcerative Colitis.,2026,10.3390/biology15141123,https://pubmed.ncbi.nlm.nih.gov/42510671/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,39693225,Pathogenic role for CD101-negative neutrophils in the type I interferon-mediated immunopathogenesis of tuberculosis.,2025,10.1016/j.celrep.2024.115072,https://pubmed.ncbi.nlm.nih.gov/39693225/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,42238595,Huayu Wan enhances immune checkpoint inhibitor efficacy in triple-negative breast cancer by normalizing tumor vasculature and remodeling the tumor immune microenvironment.,2026,10.3389/fimmu.2026.1824721,https://pubmed.ncbi.nlm.nih.gov/42238595/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,40375334,Characterization and prognostic of CD8 + TIM3 + CD101 + T cells in glioblastoma multiforme.,2025,10.1186/s13578-025-01390-1,https://pubmed.ncbi.nlm.nih.gov/40375334/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,42323888,Disease progression is associated with differential neutrophil maturation in Mycobacterium tuberculosis-infected macaques.,2026,10.1093/jimmun/vkag114,https://pubmed.ncbi.nlm.nih.gov/42323888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,42229699,S100A8/A9 blockade attenuates autoimmune neuroinflammation by regulating the heterogeneity and function of neutrophils.,2026,10.1016/j.bbi.2026.106845,https://pubmed.ncbi.nlm.nih.gov/42229699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,42374178,Integrated multi-population selection-signature scans identify putative functional genes influencing litter size in jishen black pigs.,2026,10.1186/s12864-026-12960-z,https://pubmed.ncbi.nlm.nih.gov/42374178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,41854362,Albumin-Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8&lt;sup&gt;+&lt;/sup&gt; T Cell Immunity.,2026,10.1002/advs.202523603,https://pubmed.ncbi.nlm.nih.gov/41854362/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,42077770,Effects of mixed &lt;i&gt;Lactiplantibacillus plantarum&lt;/i&gt; CD101 and &lt;i&gt;Staphylococcus simulans&lt;/i&gt; NJ201 on dry fermented sausages.,2026,10.1007/s10068-026-02143-7,https://pubmed.ncbi.nlm.nih.gov/42077770/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,40084939,CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment.,2025,10.1158/2326-6066.cir-24-0151,https://pubmed.ncbi.nlm.nih.gov/40084939/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,38901763,"Cell type-specific modulation of metabolic, immune-regulatory, and anti-microbial pathways by CD101.",2024,10.1016/j.mucimm.2024.06.004,https://pubmed.ncbi.nlm.nih.gov/38901763/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,39700955,The role of CD101 and Tim3 in the immune microenvironment of gastric cancer and their potential as prognostic biomarkers.,2025,10.1016/j.intimp.2024.113835,https://pubmed.ncbi.nlm.nih.gov/39700955/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,41190814,Transient lung eosinophilia during breakthrough influenza infection in vaccinated mice is associated with protective and balanced Type 1/2 immune responses.,2025,10.1128/jvi.00965-25,https://pubmed.ncbi.nlm.nih.gov/41190814/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,42428308,Local and systemic immune correlates of anal high-risk HPV infection and clearance in men living with HIV and men at high risk for HIV.,2026,10.3389/fmicb.2026.1855627,https://pubmed.ncbi.nlm.nih.gov/42428308/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,40974572,CD7 regulates the persistence of terminally exhausted CD8&lt;sup&gt;+&lt;/sup&gt; T cells during chronic infection.,2025,10.1016/j.celrep.2025.116316,https://pubmed.ncbi.nlm.nih.gov/40974572/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,15737213,CD4+ CD56+ blastic tumor cells express CD101 molecules.,2005,10.1111/j.0022-202x.2005.23617.x,https://pubmed.ncbi.nlm.nih.gov/15737213/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,10692025,CD101 expression by Langerhans cell histiocytosis cells.,2000,10.1046/j.1365-2559.2000.00827.x,https://pubmed.ncbi.nlm.nih.gov/10692025/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,9389317,CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation.,1997,10.1111/j.1399-0039.1997.tb02898.x,https://pubmed.ncbi.nlm.nih.gov/9389317/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,7722299,"V7, a novel leukocyte surface protein that participates in T cell activation. I. Tissue distribution and functional studies.",1995,10.4049/jimmunol.154.9.4423,https://pubmed.ncbi.nlm.nih.gov/7722299/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD101,ENSG00000134256,Unsafe,7722300,"V7, a novel leukocyte surface protein that participates in T cell activation. II. Molecular cloning and characterization of the V7 gene.",1995,10.4049/jimmunol.154.9.4434,https://pubmed.ncbi.nlm.nih.gov/7722300/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD200R1L,ENSG00000206531,Unsafe,33884657,CD200R1L is a functional evolutionary conserved activating receptor in human neutrophils.,2022,10.1002/jlb.2a0520-334r,https://pubmed.ncbi.nlm.nih.gov/33884657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD200R1L,ENSG00000206531,Unsafe,33961666,CD200R1 and CD200R1L expression is regulated during B cell development in swine and modulates the Ig production in response to the TLR7 ligand imiquimoid.,2021,10.1371/journal.pone.0251187,https://pubmed.ncbi.nlm.nih.gov/33961666/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD200R1L,ENSG00000206531,Unsafe,36379046,"Circulating CD200 is increased in the secretory phase of women with endometriosis as is endometrial mRNA, and endometrial stromal cell CD200R1 is increased in spite of reduced mRNA.",2023,10.1111/aji.13655,https://pubmed.ncbi.nlm.nih.gov/36379046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD200R1L,ENSG00000206531,Unsafe,35231818,CD200R family receptors are expressed on porcine monocytes and modulate the production of IL-8 and TNF-α triggered by TLR4 or TLR7 in these cells.,2022,10.1016/j.molimm.2022.02.019,https://pubmed.ncbi.nlm.nih.gov/35231818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD200R1L,ENSG00000206531,Unsafe,31233758,Analysis of the expression of porcine CD200R1 and CD200R1L by using newly developed monoclonal antibodies.,2019,10.1016/j.dci.2019.103417,https://pubmed.ncbi.nlm.nih.gov/31233758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD200R1L,ENSG00000206531,Unsafe,35927536,Genome-wide association study of SARS-CoV-2 infection in Chinese population.,2022,10.1007/s10096-022-04478-5,https://pubmed.ncbi.nlm.nih.gov/35927536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD200R1L,ENSG00000206531,Unsafe,18424714,An interaction between CD200 and monoclonal antibody agonists to CD200R2 in development of dendritic cells that preferentially induce populations of CD4+CD25+ T regulatory cells.,2008,10.4049/jimmunol.180.9.5946,https://pubmed.ncbi.nlm.nih.gov/18424714/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD200R1L,ENSG00000206531,Unsafe,15880066,Augmented Induction of CD4+CD25+ Treg using monoclonal antibodies to CD200R.,2005,10.1097/01.tp.0000152118.51622.f9,https://pubmed.ncbi.nlm.nih.gov/15880066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD200R1L,ENSG00000206531,Unsafe,15729177,Augmented induction of CD4+CD25+ Treg using monoclonal antibodies to CD200R.,2005,10.1097/01.tp.0000152118.51622.f9,https://pubmed.ncbi.nlm.nih.gov/15729177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD200R1L,ENSG00000206531,Unsafe,16612280,Thymocyte/splenocyte-derived CD4+CD25+Treg stimulated by anti-CD200R2 derived dendritic cells suppress mixed leukocyte cultures and skin graft rejection.,2006,10.1097/01.tp.0000214984.65520.50,https://pubmed.ncbi.nlm.nih.gov/16612280/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CD200R1L,ENSG00000206531,Unsafe,15274657,Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface.,2004,10.1111/j.1600-0897.2004.00192.x,https://pubmed.ncbi.nlm.nih.gov/15274657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDADC1,ENSG00000102543,Unsafe,40504152,CDADC1 is a vertebrate-specific dCTP deaminase that metabolizes gemcitabine and decitabine to prevent cellular toxicity.,2025,10.1073/pnas.2424409122,https://pubmed.ncbi.nlm.nih.gov/40504152/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDADC1,ENSG00000102543,Unsafe,40324085,Activity and structure of human (d)CTP deaminase CDADC1.,2025,10.1073/pnas.2424245122,https://pubmed.ncbi.nlm.nih.gov/40324085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDADC1,ENSG00000102543,Unsafe,39099665,Development and Validation of Diagnostic Models for Transcriptomic Signature Genes for Multiple Tissues in Osteoarthritis.,2024,10.2147/jir.s472118,https://pubmed.ncbi.nlm.nih.gov/39099665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDADC1,ENSG00000102543,Unsafe,42457018,3D epigenomic remodelling mediated by Foxa1 drives gemcitabine resistance in pancreatic cancer.,2026,10.1016/j.canlet.2026.218721,https://pubmed.ncbi.nlm.nih.gov/42457018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDADC1,ENSG00000102543,Unsafe,28589857,Identification of epigenetic interactions between miRNA and DNA methylation associated with gene expression as potential prognostic markers in bladder cancer.,2017,10.1186/s12920-017-0269-y,https://pubmed.ncbi.nlm.nih.gov/28589857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDADC1,ENSG00000102543,Unsafe,16955368,NYD-SP15: a novel gene potentially involved in regulating testicular development and spermatogenesis.,2006,10.1007/s10528-006-9038-x,https://pubmed.ncbi.nlm.nih.gov/16955368/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,40418379,MicroRNA-34a-5p induces cell cycle arrest and leads to spermatogenesis failure by targeting CDC25A.,2025,10.1007/s00018-025-05738-1,https://pubmed.ncbi.nlm.nih.gov/40418379/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,42448957,Novel CDK-independent function of CDC25 phosphatases in mRNA translation.,2026,10.1038/s44319-026-00852-y,https://pubmed.ncbi.nlm.nih.gov/42448957/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,41639833,The mechanism by which KAT2A increases the stability of CDC25A through acetylation to regulate glycolysis and mediate lung adenocarcinoma immune escape.,2026,10.1186/s12931-026-03544-2,https://pubmed.ncbi.nlm.nih.gov/41639833/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,42589262,Current Research in Polypharmacology for Cancer Treatment Using Dual-Target Histone Deacetylase Inhibitors.,2026,10.3390/ijms27156604,https://pubmed.ncbi.nlm.nih.gov/42589262/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,41922161,Insights into the prognostic significance of cell division cycle 25A (CDC25A) in breast cancer.,2026,10.1136/jcp-2026-210688,https://pubmed.ncbi.nlm.nih.gov/41922161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,42348113,Identification of Ferroptosis-related Genes Associated with the Prognosis of Hepatocellular Carcinoma.,2026,10.1007/s12013-026-02096-y,https://pubmed.ncbi.nlm.nih.gov/42348113/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,39974663,TDP-43/ALKBH5-mediated m&lt;sup&gt;6&lt;/sup&gt;A modification of CDC25A mRNA promotes glioblastoma growth by facilitating G1/S cell cycle transition.,2025,10.1002/mco2.70108,https://pubmed.ncbi.nlm.nih.gov/39974663/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,41373559,Identification of a Novel miR-122-5p/CDC25A Axis and Potential Therapeutic Targets for Chronic Myeloid Leukemia.,2025,10.3390/ijms262311401,https://pubmed.ncbi.nlm.nih.gov/41373559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,41829044,"Functional Characterization of &lt;i&gt;IGF2BP1&lt;/i&gt;, &lt;i&gt;CDC25A&lt;/i&gt;, and &lt;i&gt;RXFP2&lt;/i&gt; Genes: Implications for Ovarian Function and Reproductive Regulation in Goats.",2026,10.3390/ani16050836,https://pubmed.ncbi.nlm.nih.gov/41829044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,41915028,Hypoxia-induced miR-21-5p promotes autophagy by downregulating CDC25A in endometriosis.,2026,10.1093/molehr/gaag020,https://pubmed.ncbi.nlm.nih.gov/41915028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,42275647,"Pt(IV) Complexes Incorporating CDC25A/NF-κB Dual Inhibitory 1,4-Naphthoquinone Derivatives Trigger Multimodal Cell Death in A2780 Ovarian Cancer Cells.",2026,10.1021/acs.jmedchem.6c01327,https://pubmed.ncbi.nlm.nih.gov/42275647/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,41075079,Malate targets pyruvate kinase M2 to promote colorectal cancer cell cycle arrest and tumor suppression.,2025,10.1186/s43556-025-00326-y,https://pubmed.ncbi.nlm.nih.gov/41075079/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,40342881,"Novel Genetic Variants of CDC25A Significantly Increase Risk of Spermatogenesis Arrest in Men from Bengali Population, India: A Cross-Sectional Study.",2025,10.4103/jhrs.jhrs_26_25,https://pubmed.ncbi.nlm.nih.gov/40342881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,41502467,USP1 regulates esophageal cancer progression through CDC25A deubiquitination to regulate CDK1 expression.,2026,10.1007/s13205-025-04663-1,https://pubmed.ncbi.nlm.nih.gov/41502467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,40548841,Circadian Gene NPAS2 Relieves Hypertrophic Scar Formation via CDC25A-Mediated Fibroblasts Activity.,2025,10.1111/jcmm.70643,https://pubmed.ncbi.nlm.nih.gov/40548841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,41220585,Investigating the causal role of cellular senescence-related genes in preeclampsia: a multi-omics Mendelian randomization study with differential expression analysis.,2025,10.3389/fendo.2025.1661666,https://pubmed.ncbi.nlm.nih.gov/41220585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,42922071,Anticancer Effect of Co(III) Complex of a Thiourea Derivative on Inhibiting Breast Cancer Cell Proliferation Using In Silico and In Vitro Evaluations. ,2026,10.1002/cmdc.70544,https://pubmed.ncbi.nlm.nih.gov/42922071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,40216745,CDC25A inhibition sensitizes melanoma cells to doxorubicin and NK cell therapy.,2025,10.1038/s41419-025-07598-w,https://pubmed.ncbi.nlm.nih.gov/40216745/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,41073893,Identification and tissue-level validation of ferroptosis-related genes in small intestinal neuroendocrine neoplasms based on machine learning.,2025,10.1186/s12876-025-04326-8,https://pubmed.ncbi.nlm.nih.gov/41073893/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,41526964,Multi-omics analysis identifies BUB1B as a cell cycle-related driver of bladder cancer progression.,2026,10.1186/s12957-025-04175-5,https://pubmed.ncbi.nlm.nih.gov/41526964/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,42537828,SMG1 in hepatocellular carcinoma: A context-dependent tumor suppressor and a targetable node for NMD-directed immunotherapy.,2026,10.1016/j.critrevonc.2026.105508,https://pubmed.ncbi.nlm.nih.gov/42537828/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,42689127,2-O-Methylmagnolol suppresses oral squamous cell carcinoma progression by targeting c-MYC signaling.,2026,10.1016/j.jds.2025.07.3483,https://pubmed.ncbi.nlm.nih.gov/42689127/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,42201394,Targeting KIF18B overcomes oxaliplatin resistance in esophageal squamous cell carcinoma via suppression of the ATR/CHK1 axis.,2026,10.1007/s00438-026-02440-0,https://pubmed.ncbi.nlm.nih.gov/42201394/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,39830513,Development and experimental validation of dephosphorylation-related biomarkers to assess prognosis and immunotherapeutic response in gliomas.,2024,10.3389/fimmu.2024.1488894,https://pubmed.ncbi.nlm.nih.gov/39830513/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,41871056,Elucidating the potential carcinogenic molecular mechanisms of parabens in head and neck squamous cell carcinoma through network toxicology and molecular docking.,2026,10.1371/journal.pone.0333867,https://pubmed.ncbi.nlm.nih.gov/41871056/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,40197384,Identification of N6-methyladenosine-associated ferroptosis biomarkers in cervical cancer.,2025,10.1186/s41065-025-00418-3,https://pubmed.ncbi.nlm.nih.gov/40197384/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,42907995,Astragali Radix-Curcumae Rhizoma synergistically potentiates 5-fluorouracil antitumor efficacy in colorectal cancer by disrupting DNA repair-cell cycle coordination.,2026,10.1186/s13020-026-01449-2,https://pubmed.ncbi.nlm.nih.gov/42907995/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,40081286,Targeting cell cycle arrest in breast cancer by phytochemicals from Caryto urens L. fruit ethyl acetate fraction: in silico and in vitro validation.,2025,10.1016/j.jaim.2024.101095,https://pubmed.ncbi.nlm.nih.gov/40081286/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,40599792,Precision prognostication in neuroblastomas via clinically validated E2F activity signatures.,2025,10.3389/fimmu.2025.1612667,https://pubmed.ncbi.nlm.nih.gov/40599792/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,38611789,Cynaroside Induces G1 Cell Cycle Arrest by Downregulating Cell Division Cycle 25A in Colorectal Cancer.,2024,10.3390/molecules29071508,https://pubmed.ncbi.nlm.nih.gov/38611789/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25A,ENSG00000164045,Unsafe,42050204,Celecoxib potentiates ribociclib-induced apoptosis and anti-tumor activity by co-targeting COX-2/NF-κB and PI3K/AKT/mTOR pathways in hormone receptor-positive/HER2-negative breast cancer.,2026,10.1007/s10495-026-02340-z,https://pubmed.ncbi.nlm.nih.gov/42050204/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,41547943,CDC25C downregulation suppresses HCC growth via mitochondrial stress-induced autophagy and apoptosis.,2026,10.1038/s41598-026-36351-2,https://pubmed.ncbi.nlm.nih.gov/41547943/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,41021167,Cell division cycle 25 C (CDC25C) mediates cell-cycle progression and immune evasion in glioma.,2025,10.1007/s12672-025-03596-8,https://pubmed.ncbi.nlm.nih.gov/41021167/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,42260221,"Integrated transcriptomics, network pharmacology and clinical expression validation reveal the prognostic significance of PANoptosis-related genes in cordycepin-treated lung adenocarcinoma.",2026,10.1007/s12672-026-05134-6,https://pubmed.ncbi.nlm.nih.gov/42260221/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,42900322,Transcriptomics analysis and experimental assay to screen prognostic genes of N6-methyladenosine RNA methylation related to cuproptosis in colorectal cancer.,2026,10.1007/s12032-026-03441-0,https://pubmed.ncbi.nlm.nih.gov/42900322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,42780549,Pogostemon Cablin Aqueous Extract (PCAE) Induces Mitotic Delay by Downregulating CDC2/Cyclin B1 in TNBC Cells (MDA-MB-231).,2026,10.1155/bri/4127073,https://pubmed.ncbi.nlm.nih.gov/42780549/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,41587503,Inhibition of CDC25C attenuates IL-17A-driven keratinocyte hyperproliferation and psoriasis progression.,2026,10.1016/j.bbrc.2026.153342,https://pubmed.ncbi.nlm.nih.gov/41587503/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,41602397,Prognostic value and experimental validation of atherosclerosis-derived pathogenic genes in colorectal cancer.,2025,10.3389/fonc.2025.1728087,https://pubmed.ncbi.nlm.nih.gov/41602397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,41771324,Mechanisms of bisphenols-induced cervical cancer: A multidimensional bioinformatics analysis.,2026,10.1016/j.reprotox.2026.109209,https://pubmed.ncbi.nlm.nih.gov/41771324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,39981934,Abnormal expression of CDC25C in NSCLC is influenced by transcriptional and RNA N6‑methyladenosine‑mediated post‑transcriptional regulation.,2025,10.3892/ijo.2025.5733,https://pubmed.ncbi.nlm.nih.gov/39981934/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,42520473,Oprozomib inhibits proliferation and promotes apoptosis in gallbladder carcinoma cells through MAPK signaling pathway.,2026,10.1016/j.tranon.2026.102959,https://pubmed.ncbi.nlm.nih.gov/42520473/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,42100321,"Assessing the toxicological effects of exposure to polyethylene terephthalate on hepatocellular carcinoma: insights from network toxicology, molecular docking, molecular dynamics, and experimental validation.",2026,10.3389/fphar.2026.1772751,https://pubmed.ncbi.nlm.nih.gov/42100321/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,39789853,AURKA/PLK1/CDC25C Axis as a Novel Therapeutic Target in INI1-Deficient Epithelioid Sarcoma.,2025,10.1111/cas.16438,https://pubmed.ncbi.nlm.nih.gov/39789853/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,41019083,"Air pollution-related immune gene prognostic signature for hepatocellular carcinoma: network toxicology, machine learning and multi-omics analysis.",2025,10.3389/fimmu.2025.1638445,https://pubmed.ncbi.nlm.nih.gov/41019083/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,40581088,SPDYE3 promotes cell cycle and LUSC progression by regulating the CDC25C/CDK1 pathway.,2025,10.1016/j.biocel.2025.106825,https://pubmed.ncbi.nlm.nih.gov/40581088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,41153004,Correction: Porcine reproductive and respiratory syndrome virus inhibits MARC-145 proliferation via inducing apoptosis and G2/M arrest by activation of Chk/Cdc25C and p53/p21 pathway.,2025,10.1186/s12985-025-02992-4,https://pubmed.ncbi.nlm.nih.gov/41153004/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,41555381,Etiology of polyploid giant cancer cells: a new frontier in cancer biology.,2026,10.1186/s12935-025-04079-0,https://pubmed.ncbi.nlm.nih.gov/41555381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,39949984,SHCBP1 is a novel regulator of PLK1 phosphorylation and promotes prostate cancer bone metastasis.,2025,10.1002/mco2.70082,https://pubmed.ncbi.nlm.nih.gov/39949984/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,41862463,Oncogenic GPRIN1 sustains proliferation and mitochondrial homeostasis via dual‑layer CDK1-PI3K/Akt signalling in gallbladder cancer.,2026,10.1038/s41419-026-08550-2,https://pubmed.ncbi.nlm.nih.gov/41862463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,40509264,Fenbendazole Exhibits Antitumor Activity Against Cervical Cancer Through Dual Targeting of Cancer Cells and Cancer Stem Cells: Evidence from In Vitro and In Vivo Models.,2025,10.3390/molecules30112377,https://pubmed.ncbi.nlm.nih.gov/40509264/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,39834856,Revisiting phosphoregulation of Cdc25C during M-phase induction.,2025,10.1016/j.isci.2024.111603,https://pubmed.ncbi.nlm.nih.gov/39834856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,38410201,Preparation of hepatocellular carcinoma mRNA vaccines based on potential tumor targets and immunophenotypes.,2024,10.21037/tcr-23-1237,https://pubmed.ncbi.nlm.nih.gov/38410201/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,40671231,Telomere Maintenance Characteristics Predict Prognosis and Therapeutic Response in Colorectal Cancer.,2026,10.2174/0115680266397024250710105241,https://pubmed.ncbi.nlm.nih.gov/40671231/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,40565165,Targeting WEE1 Kinase for Breast Cancer Therapeutics: An Update.,2025,10.3390/ijms26125701,https://pubmed.ncbi.nlm.nih.gov/40565165/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,37969406,Identification of tumor antigens and immune subtypes of hepatocellular carcinoma for mRNA vaccine development.,2023,10.4251/wjgo.v15.i10.1717,https://pubmed.ncbi.nlm.nih.gov/37969406/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,40317411,Constructing a mitochondrial-related genes model based on machine learning for predicting the prognosis and therapeutic effect in colorectal cancer.,2025,10.1007/s12672-025-02462-x,https://pubmed.ncbi.nlm.nih.gov/40317411/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,39442252,Mode of action exploration for prostate epithelial cell injury caused by bisphenol A.,2024,10.1016/j.ecoenv.2024.117228,https://pubmed.ncbi.nlm.nih.gov/39442252/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,41377579,Macrophage membrane coating enhances the therapeutic effects of &lt;i&gt;Houttuynia cordata&lt;/i&gt; exosome-like nanovesicles against triple-negative breast cancer.,2025,10.1016/j.mtbio.2025.102604,https://pubmed.ncbi.nlm.nih.gov/41377579/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,40613523,Role of telomere maintenance genes as a predictive biomarker for colorectal cancer immunotherapy response and prognosis.,2025,10.17305/bb.2025.12053,https://pubmed.ncbi.nlm.nih.gov/40613523/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,38817663,Cell division cyclin 25C knockdown inhibits hepatocellular carcinoma development by inducing endoplasmic reticulum stress.,2024,10.3748/wjg.v30.i19.2564,https://pubmed.ncbi.nlm.nih.gov/38817663/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,39913001,A new signature associated with anoikis predicts the outcome and immune infiltration in nasopharyngeal carcinoma.,2025,10.1007/s12672-025-01869-w,https://pubmed.ncbi.nlm.nih.gov/39913001/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC25C,ENSG00000158402,Unsafe,40225560,Nanocatalytic system releases overloaded zinc ions and ROS to induce Znproptosis and interrupt cell cycle through inhibiting Akt/mTOR pathway.,2025,10.7150/thno.107025,https://pubmed.ncbi.nlm.nih.gov/40225560/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,42112556,Identifying Candidate Genes for Late-Feathering Subtypes of the Shouguang Chicken by Genome-Wide Association Study and Differential Expression Analysis.,2026,10.1002/age.70115,https://pubmed.ncbi.nlm.nih.gov/42112556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,40856040,Direct and indirect effects of spliceosome disruption compromise gene regulation by nonsense-mediated mRNA decay.,2025,10.1080/15476286.2025.2552517,https://pubmed.ncbi.nlm.nih.gov/40856040/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,39747150,CDC40 suppression induces CDCA5 splicing defects and anti-proliferative effects in lung cancer cells.,2025,10.1038/s41598-024-83337-z,https://pubmed.ncbi.nlm.nih.gov/39747150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,38759022,Increased Diagnostic Yield by Reanalysis of Whole Exome Sequencing Data in Mitochondrial Disease.,2024,10.3233/jnd-240020,https://pubmed.ncbi.nlm.nih.gov/38759022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,39415054,Structure of a step II catalytically activated spliceosome from Chlamydomonas reinhardtii.,2025,10.1038/s44318-024-00274-3,https://pubmed.ncbi.nlm.nih.gov/39415054/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,32913542,MiR-422a in gastric cancer cells directly targets CDC40 and modulates cell proliferation.,2020,,https://pubmed.ncbi.nlm.nih.gov/32913542/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,35509373,Identification of qPCR reference genes suitable for normalising gene expression in the developing mouse embryo.,2021,10.12688/wellcomeopenres.16972.2,https://pubmed.ncbi.nlm.nih.gov/35509373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,33220177,Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly.,2021,10.1016/j.neuron.2020.10.035,https://pubmed.ncbi.nlm.nih.gov/33220177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,39090210,Screening of reliable reference genes for the normalization of RT-qPCR in chicken liver tissues and LMH cells.,2024,10.1038/s41598-024-68752-6,https://pubmed.ncbi.nlm.nih.gov/39090210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,32033399,Combinatorial Discriminant Analysis Applied to RNAseq Data Reveals a Set of 10 Transcripts as Signatures of Exposure of Cattle to Mycobacterium avium subsp. paratuberculosis.,2020,10.3390/ani10020253,https://pubmed.ncbi.nlm.nih.gov/32033399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,30699165,Identification of qPCR reference genes suitable for normalizing gene expression in the mdx mouse model of Duchenne muscular dystrophy.,2019,10.1371/journal.pone.0211384,https://pubmed.ncbi.nlm.nih.gov/30699165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,35252180,miR-1269a and miR-1269b: Emerging Carcinogenic Genes of the miR-1269 Family.,2022,10.3389/fcell.2022.809132,https://pubmed.ncbi.nlm.nih.gov/35252180/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,27349221,HBx-induced MiR-1269b in NF-κB dependent manner upregulates cell division cycle 40 homolog (CDC40) to promote proliferation and migration in hepatoma cells.,2016,10.1186/s12967-016-0949-y,https://pubmed.ncbi.nlm.nih.gov/27349221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,20419786,PRP-17 and the pre-mRNA splicing pathway are preferentially required for the proliferation versus meiotic development decision and germline sex determination in Caenorhabditis elegans.,2010,10.1002/dvdy.22274,https://pubmed.ncbi.nlm.nih.gov/20419786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,28966666,Identification of potential therapeutic target genes and miRNAs for primary myelofibrosis with microarray analysis.,2017,10.3892/etm.2017.4912,https://pubmed.ncbi.nlm.nih.gov/28966666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,30847849,Identification of reference genes for quantitative PCR during C3H10T1/2 chondrogenic differentiation.,2019,10.1007/s11033-019-04713-x,https://pubmed.ncbi.nlm.nih.gov/30847849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,25328987,MicroRNA-378 inhibits cell growth and enhances L-OHP-induced apoptosis in human colorectal cancer.,2014,10.1002/iub.1317,https://pubmed.ncbi.nlm.nih.gov/25328987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,15133121,The Saccharomyces cerevisiae gene CDC40/PRP17 controls cell cycle progression through splicing of the ANC1 gene.,2004,10.1093/nar/gkh574,https://pubmed.ncbi.nlm.nih.gov/15133121/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,9769104,"Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control.",1998,10.1017/s1355838298980712,https://pubmed.ncbi.nlm.nih.gov/9769104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,22789856,Context dependent splicing functions of Bud31/Ycr063w define its role in budding and cell cycle progression.,2012,10.1016/j.bbrc.2012.06.156,https://pubmed.ncbi.nlm.nih.gov/22789856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,27633496,miR-378 inhibits cell growth and enhances apoptosis in human myelodysplastic syndromes.,2016,10.3892/ijo.2016.3689,https://pubmed.ncbi.nlm.nih.gov/27633496/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC40,ENSG00000168438,Unsafe,25524563,The spliceosomal PRP19 complex of trypanosomes.,2015,10.1111/mmi.12910,https://pubmed.ncbi.nlm.nih.gov/25524563/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,42703585,Identification of a novel and a recurrent &lt;i&gt;CDC45&lt;/i&gt; variant in a Chinese family with Meier-Gorlin syndrome 7 and a literature review.,2026,10.3389/fgene.2026.1893476,https://pubmed.ncbi.nlm.nih.gov/42703585/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,41620759,Molecular diagnosis of rare biallelic CDC45 gene variants causing Meier-Gorlin syndrome-7 using whole exome sequencing.,2026,10.1186/s40246-026-00922-1,https://pubmed.ncbi.nlm.nih.gov/41620759/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,41472935,Identification and Validation of the Prognostic Value of PTTG1-Related Genes in Hepatocellular Carcinoma by Mendelian Randomization and Single-Cell Transcriptome Analysis.,2026,10.30498/ijb.2025.543634.4221,https://pubmed.ncbi.nlm.nih.gov/41472935/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,42810495,Rhein attenuates neointimal hyperplasia by inhibiting VSMC proliferation via MAPK-mediated downregulation of CDC45.,2026,10.1016/j.ejphar.2026.179371,https://pubmed.ncbi.nlm.nih.gov/42810495/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,42733061,Structural insights into Sld3-Sld7-dependent Cdc45 loading during replication initiation.,2026,10.1038/s41467-026-76309-6,https://pubmed.ncbi.nlm.nih.gov/42733061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,42374456,Acidosis-associated gene signature defines novel subtypes and dual-target therapeutic candidates in breast cancer.,2026,10.1186/s12967-026-08365-x,https://pubmed.ncbi.nlm.nih.gov/42374456/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,41699006,"Dysregulated expression of cell cycle regulators CDC20, PLK1, BUB1, CDC45, CDCA5 in pancreatic ductal adenocarcinoma.",2026,10.1038/s41598-026-37399-w,https://pubmed.ncbi.nlm.nih.gov/41699006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,42031958,A macrophage MHC-I axis links intratumoral heterogeneity to terminal CD8&lt;sup&gt;+&lt;/sup&gt; T cell exhaustion in lung adenocarcinoma.,2026,10.1038/s41698-026-01446-6,https://pubmed.ncbi.nlm.nih.gov/42031958/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,39811603,Functional Analysis and Experimental Validation of the Prognostic and Immune Effects of the Oncogenic Protein CDC45 in Breast Cancer.,2025,10.2147/bctt.s497975,https://pubmed.ncbi.nlm.nih.gov/39811603/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,41850053,WDHD1 promotes hepatocellular carcinoma progression by affecting the cell cycle and immune evasion.,2026,10.1016/j.tranon.2026.102735,https://pubmed.ncbi.nlm.nih.gov/41850053/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,42479720,CDCA8 regulates ATP5F1A protein stability and malignant phenotypes in wilms tumor cells: Prognostic implications and mechanistic insights.,2026,10.1371/journal.pone.0353696,https://pubmed.ncbi.nlm.nih.gov/42479720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,41888149,Genome-wide transcriptional profiling identifies molecular markers associated with early carcinogenesis in high-grade bladder cancer.,2026,10.1038/s41598-026-36530-1,https://pubmed.ncbi.nlm.nih.gov/41888149/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,42321192,Replication origin firing capacity indicates ATR inhibitor sensitivity.,2026,10.1038/s41467-026-74588-7,https://pubmed.ncbi.nlm.nih.gov/42321192/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,40920075,Sld3CBD-Cdc45 structural insights into Cdc45 recruitment for CMG complex formation during DNA replication.,2025,10.7554/elife.101717,https://pubmed.ncbi.nlm.nih.gov/40920075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,41681894,Comprehensive Characterization of Stem Cell Landscape Identifies Novel Stemness-Relevant Genes for Nasopharyngeal Carcinoma Therapy.,2026,10.3390/cancers18030422,https://pubmed.ncbi.nlm.nih.gov/41681894/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,42235152,Comparative transcriptome profiling of leg muscle development from the embryonic to growth stages in Huanglang chickens.,2026,10.1016/j.psj.2026.107190,https://pubmed.ncbi.nlm.nih.gov/42235152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,42487740,Analyzing DNA Replication Fork Stability and Collapse Using Chromatin Fiber Analysis and the R-ODD-BLOBS Program.,2026,10.34133/csbj.0140,https://pubmed.ncbi.nlm.nih.gov/42487740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,41963605,SLC25A1 upregulation promotes HNSCC cisplatin resistance via H3K27ac-mediated cellular senescence.,2026,10.1038/s41698-026-01411-3,https://pubmed.ncbi.nlm.nih.gov/41963605/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,41258386,High ORC6 expression is a prognostic indicator of poor survival in glioma patients.,2025,10.1038/s41598-025-24630-3,https://pubmed.ncbi.nlm.nih.gov/41258386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,38515458,Validation of CDC45 as a novel biomarker for diagnosis and prognosis of gastric cancer.,2024,10.7717/peerj.17130,https://pubmed.ncbi.nlm.nih.gov/38515458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,40972424,Discovery of dimeric guaianolides with all carbon linkers as potential antihepatoma agents.,2025,10.1016/j.ejmech.2025.118160,https://pubmed.ncbi.nlm.nih.gov/40972424/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,41903286,"Design and synthesis of novel 1,2,4-triazolobenzene sulfonamide derivatives as selective CDK1 inhibitors with potent in vivo anticancer efficacy.",2026,10.1016/j.ejmech.2026.118799,https://pubmed.ncbi.nlm.nih.gov/41903286/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,37642814,Elevated CDC45 Expression Predicts Poorer Overall Survival Prognoses and Worse Immune Responses for Kidney Renal Clear Cell Carcinoma via Single-Cell and Bulk RNA-Sequencing.,2024,10.1007/s10528-023-10500-y,https://pubmed.ncbi.nlm.nih.gov/37642814/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,40390492,Identification of key biomarker genes in liver hepatocellular carcinoma and kidney renal clear cell carcinoma progression: A shared high-throughput screening and molecular docking method with potentials for targeted therapeutic interventions.,2025,10.1016/j.jgeb.2025.100497,https://pubmed.ncbi.nlm.nih.gov/40390492/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,42583093,"Exploring the molecular basis of &lt;i&gt;Panax notoginseng&lt;/i&gt; mediated inhibition of cervical cancer through machine learning, transcriptomics analysis, network pharmacology, molecular docking, and in-silico simulation approaches.",2026,10.1093/bioadv/vbag164,https://pubmed.ncbi.nlm.nih.gov/42583093/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,40255404,Clinical potential and experimental validation of prognostic genes in hepatocellular carcinoma revealed by risk modeling utilizing single cell and transcriptome constructs.,2025,10.3389/fimmu.2025.1541252,https://pubmed.ncbi.nlm.nih.gov/40255404/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,37985379,IGF2BP2 promotes glycolysis and hepatocellular carcinoma stemness by stabilizing CDC45 mRNA via m6A modification.,2023,10.1080/15384101.2023.2283328,https://pubmed.ncbi.nlm.nih.gov/37985379/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,38589907,CDC45 promotes the stemness and metastasis in lung adenocarcinoma by affecting the cell cycle.,2024,10.1186/s12967-024-05038-5,https://pubmed.ncbi.nlm.nih.gov/38589907/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,40585419,Exploring the role of key gene PTTG1 in clear cell renal carcinoma based on bioinformatics analysis and In-vitro cell experiments.,2025,10.1093/toxres/tfaf078,https://pubmed.ncbi.nlm.nih.gov/40585419/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC45,ENSG00000093009,Unsafe,40533495,USP37 prevents premature disassembly of stressed replisomes by TRAIP.,2025,10.1038/s41467-025-60139-z,https://pubmed.ncbi.nlm.nih.gov/40533495/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,42449933,H3K4me3 and H3K27ac Promote ccRCC Proliferation Through the CDC6-EXOSC5 Axis.,2026,10.3390/ijms27135657,https://pubmed.ncbi.nlm.nih.gov/42449933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,42014675,CDC6/THBS1 accelerates pancreatic cancer progression via AKT-mediated glycolytic reprogramming.,2026,10.1038/s41419-026-08758-2,https://pubmed.ncbi.nlm.nih.gov/42014675/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,42325020,Transcription factor TFAP2A upregulates CDC6 to mediate glycolysis and promote stemness in lung adenocarcinoma cells.,2026,10.14670/hh-25-111,https://pubmed.ncbi.nlm.nih.gov/42325020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,41578340,Therapeutic efficacy monitoring in canine lymphoma patients via quantifying CDC6 plasma levels.,2026,10.1186/s12917-025-05263-0,https://pubmed.ncbi.nlm.nih.gov/41578340/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,42591444,Transcriptomic and experimental validation identify biomarkers and regulatory mechanisms associated with the aryl hydrocarbon receptor in nasopharyngeal carcinoma.,2026,10.21037/tcr-2026-0879,https://pubmed.ncbi.nlm.nih.gov/42591444/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,42907421,Meier-GORLIN Syndrome Caused by Compound Heterozygous CDC6 Variants.,2026,10.1002/ajmg.a.70334,https://pubmed.ncbi.nlm.nih.gov/42907421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,41724787,PRDM1 restricts bladder cancer progression and enhances chemosensitivity by suppressing OTUD6A-mediated deubiquitination of CDC6.,2026,10.1038/s41419-026-08498-3,https://pubmed.ncbi.nlm.nih.gov/41724787/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,40993621,CDC6 as a pan-cancer immunological and prognostic biomarker and its role in suppressing melanoma malignancy.,2025,10.1186/s12885-025-14782-w,https://pubmed.ncbi.nlm.nih.gov/40993621/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,42811518,Dual CHK1 and WNT Inhibition as a Synergistic Therapy for Gastrointestinal Neuroendocrine Carcinoma.,2026,10.1158/2767-9764.crc-26-0351,https://pubmed.ncbi.nlm.nih.gov/42811518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,41339304,Interaction between CDC6 and Tmod3 accelerates resistance to paclitaxel through focal adhesion assembly.,2025,10.1038/s41392-025-02490-7,https://pubmed.ncbi.nlm.nih.gov/41339304/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,41258438,Putrescine functions as a metabolic checkpoint in replication stress-induced senescence.,2025,10.1007/s00018-025-05962-9,https://pubmed.ncbi.nlm.nih.gov/41258438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,39904279,Comprehensive multi-omics analysis showed that CDC6 is a potential prognostic and immunotherapy biomarker for multiple cancer types including HCC.,2025,10.1016/j.tranon.2025.102314,https://pubmed.ncbi.nlm.nih.gov/39904279/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,41316737,A YAP/TAZ-CDC6 Axis Initiates and Maintains Malignant Transformation.,2026,10.1111/cas.70279,https://pubmed.ncbi.nlm.nih.gov/41316737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,42365339,Identification and validation of stemness-associated hub genes in cervical cancer: a bioinformatics and experimental study.,2026,10.1186/s12957-026-04472-7,https://pubmed.ncbi.nlm.nih.gov/42365339/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,41580178,CDC6 promotes keratinocyte senescence through the CCND1/P53 signaling in ischemia-reperfusion injury-induced pressure injury.,2026,10.1016/j.yexcr.2026.114903,https://pubmed.ncbi.nlm.nih.gov/41580178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,42800881,AI-powered histopathology classifiers identify transcriptomic biomarkers associated with cell cycle regulation and increased mitotic activity in poorly differentiated neuroendocrine carcinoma.,2026,10.1186/s40246-026-01032-8,https://pubmed.ncbi.nlm.nih.gov/42800881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,41283970,CDC6 promotes the development and progression of clear cell renal cell carcinoma via upregulating RRM2.,2025,10.1007/s13577-025-01327-3,https://pubmed.ncbi.nlm.nih.gov/41283970/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,41660070,Study on biomarkers associated with epigenetic factors in endometriosis combining transcriptome with experimental validation.,2026,10.7717/peerj.20703,https://pubmed.ncbi.nlm.nih.gov/41660070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,40269003,CDC6 as early biomarker for myocardial infarction with acute cellular senescence and repair mechanisms.,2025,10.1038/s41598-025-94988-x,https://pubmed.ncbi.nlm.nih.gov/40269003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,41777648,RPL28 mediates sorafenib resistance in hepatocellular carcinoma by downregulating CDC6 expression.,2026,10.3389/fonc.2026.1741406,https://pubmed.ncbi.nlm.nih.gov/41777648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,42314223,Response of MRC-5 human lung fibroblasts to FLASH and conventional radiotherapy: A study on differential DNA damage and transcriptomic response.,2026,10.1016/j.compbiolchem.2026.109198,https://pubmed.ncbi.nlm.nih.gov/42314223/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,39582087,SKP2 inhibition activates tumor cell-intrinsic immunity by inducing DNA replication stress and genomic instability.,2025,10.1038/s41416-024-02909-y,https://pubmed.ncbi.nlm.nih.gov/39582087/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,40773798,Genetic silencing of CDC6 via AAV2-Delivered shRNA as a novel cancer genetics-based therapy for cervical carcinoma.,2025,10.1016/j.cancergen.2025.08.001,https://pubmed.ncbi.nlm.nih.gov/40773798/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,41719335,A Meier-Gorlin syndrome mutation impairs the loading of the MCM2-7 complex during DNA replication initiation.,2026,10.1073/pnas.2526022123,https://pubmed.ncbi.nlm.nih.gov/41719335/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,40955780,Glabridin from &lt;i&gt;Glycyrrhiza glabra&lt;/i&gt; L. Exhibits Anti-Triple-Negative Breast Cancer Effects by Regulating Various Cell Cycle Genes.,2025,10.1021/acs.jafc.5c04346,https://pubmed.ncbi.nlm.nih.gov/40955780/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,39262459,Comprehensive pan-cancer analysis reveals CDC6 as a potential immunomodulatory agent and promising therapeutic target in pancreatic cancer.,2024,10.21037/tcr-24-505,https://pubmed.ncbi.nlm.nih.gov/39262459/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,41667842,"Integration of ploidy, Orc1/Cdc6 homolog function, and lysine acetylation with phosphate limitation and UV stress responses of Haloferax volcanii.",2026,10.1007/s00792-026-01420-x,https://pubmed.ncbi.nlm.nih.gov/41667842/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,39684684,Exploring Bioinformatics Tools to Analyze the Role of CDC6 in the Progression of Polycystic Ovary Syndrome to Endometrial Cancer by Promoting Immune Infiltration.,2024,10.3390/ijms252312974,https://pubmed.ncbi.nlm.nih.gov/39684684/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,42646930,Long-Term Oral Exposure to Chlorophenylacetonitrile Induces Gastrointestinal Morphological Alterations and Splenic Transcriptomic Reprogramming in Mice.,2026,10.3390/toxics14080647,https://pubmed.ncbi.nlm.nih.gov/42646930/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,40356904,An immune cell activation signature reflected hepatocellular carcinoma heterogeneity and predicted clinical outcomes.,2025,10.3389/fimmu.2025.1534611,https://pubmed.ncbi.nlm.nih.gov/40356904/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,39739618,A Distinguished Roadmap of Fibroblast Senescence in Predicting Immunotherapy Response and Prognosis Across Human Cancers.,2025,10.1002/advs.202406624,https://pubmed.ncbi.nlm.nih.gov/39739618/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDC6,ENSG00000094804,Unsafe,37945594,The integrative multi-omics approach identifies the novel competing endogenous RNA (ceRNA) network in colorectal cancer.,2023,10.1038/s41598-023-46620-z,https://pubmed.ncbi.nlm.nih.gov/37945594/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,42180929,The role of the &lt;i&gt;CDCA&lt;/i&gt; gene family in tumor stemness maintenance and drug sensitivity.,2026,10.21037/tcr-2025-1-2654,https://pubmed.ncbi.nlm.nih.gov/42180929/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,41966223,Proteomic Analysis of Paired FFPE Tissue and Extracellular Vesicles Reveals Proteins Associated with Recurrence in Stage II Colorectal Cancer.,2026,10.1021/acs.jproteome.5c01148,https://pubmed.ncbi.nlm.nih.gov/41966223/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,40565058,Overexpression of &lt;i&gt;CDCA2&lt;/i&gt; in Diffuse Large B-Cell Lymphoma Promotes Cell Proliferation and Bortezomib Sensitivity.,2025,10.3390/ijms26125596,https://pubmed.ncbi.nlm.nih.gov/40565058/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,40166636,Identification and validation of biomarkers associated with mitochondrial dysfunction and ferroptosis in rat spinal cord injury.,2025,10.3389/fneur.2025.1526966,https://pubmed.ncbi.nlm.nih.gov/40166636/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,42405025,Integrative Transcriptomic Analysis Identifies Hypoxia-responsive Cell Cycle Hub Genes as Prognostic Markers in Glioblastoma.,2026,10.1177/09727531261453688,https://pubmed.ncbi.nlm.nih.gov/42405025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,41844234,A CDCA2-MYC positive feedback loop controls cancer cells survival.,2026,10.1098/rsob.250075,https://pubmed.ncbi.nlm.nih.gov/41844234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,42348440,PHD1-dependent hydroxylation of RepoMan (CDCA2) on P604 modulates the control of mitotic progression.,2026,10.7554/elife.108131,https://pubmed.ncbi.nlm.nih.gov/42348440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,42627616,"Identification of disulfidptosis-related molecular subtypes in pleural mesothelioma demonstrates a correlation with the immune infiltration, prognosis and therapy efficacy.",2026,10.1007/s12672-026-05557-1,https://pubmed.ncbi.nlm.nih.gov/42627616/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,41216230,Role of cell division cycle associated 2 in ovarian cancer: Effects on tumor progression and cisplatin resistance.,2025,10.25259/cytojournal_59_2025,https://pubmed.ncbi.nlm.nih.gov/41216230/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,41646605,"The Effect of Preeclampsia on the Cell Adhesion, Migration, and Proliferation Potential of Human Umbilical Cord-Derived Mesenchymal Stem Cells.",2026,10.7759/cureus.100783,https://pubmed.ncbi.nlm.nih.gov/41646605/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,40245179,Decoding the Role of CDCA Genes in Breast Cancer Progression: Insights From in Silico and Functional Assay.,2025,10.1111/ajco.14173,https://pubmed.ncbi.nlm.nih.gov/40245179/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,37733705,A pan-cancer analysis reveals the diagnostic and prognostic role of CDCA2 in low-grade glioma.,2023,10.1371/journal.pone.0291024,https://pubmed.ncbi.nlm.nih.gov/37733705/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,38988558,Comprehensive molecular analyses and experimental validation of CDCAs with potential implications in kidney renal papillary cell carcinoma prognosis.,2024,10.1016/j.heliyon.2024.e33045,https://pubmed.ncbi.nlm.nih.gov/38988558/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,41456064,Unraveling the molecular landscape of pancreatic cancer: a systems biology approach to identify therapeutic targets.,2025,10.1007/s12672-025-04197-1,https://pubmed.ncbi.nlm.nih.gov/41456064/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,42720907,MYBL2 promotes malignant phenotypes and M2-like macrophage polarization through CCL2 in non-small cell lung cancer.,2026,10.1007/s11010-026-05733-5,https://pubmed.ncbi.nlm.nih.gov/42720907/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,40723231,MicroRNA Signatures in Lung Adenocarcinoma Metastases: Exploring the Oncogenic Targets of Tumor-Suppressive &lt;i&gt;miR-195-5p&lt;/i&gt; and &lt;i&gt;miR-195-3p&lt;/i&gt;.,2025,10.3390/cancers17142348,https://pubmed.ncbi.nlm.nih.gov/40723231/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,40783878,Development and validation of G2M signature-based prognostic model for stratifying colon cancer prognosis.,2025,10.1007/s12672-025-03355-9,https://pubmed.ncbi.nlm.nih.gov/40783878/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,41024449,Genetic Determinants of Fatty Acid Composition in Subcutaneous and Visceral Adipose Tissue.,2025,10.1002/oby.70045,https://pubmed.ncbi.nlm.nih.gov/41024449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,39924497,CDCA genes as prognostic and therapeutic targets in Colon adenocarcinoma.,2025,10.1186/s41065-025-00368-w,https://pubmed.ncbi.nlm.nih.gov/39924497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,37750838,E2F3/CDCA2 reduces radiosensitivity in gastric adenocarcinoma by activating PI3K/AKT pathway.,2023,10.1259/bjr.20230477,https://pubmed.ncbi.nlm.nih.gov/37750838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,39288736,"The Role of CDCA2 in tumor genesis, prognosis and future treatments.",2024,10.1016/j.ejca.2024.114308,https://pubmed.ncbi.nlm.nih.gov/39288736/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,38599441,Integration analysis of cell division cycle-associated family genes revealed potential mechanisms of gliomagenesis and constructed an artificial intelligence-driven prognostic signature.,2024,10.1016/j.cellsig.2024.111168,https://pubmed.ncbi.nlm.nih.gov/38599441/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,39844908,"DEPDC1B, CDCA2, APOBEC3B, and TYMS are potential hub genes and therapeutic targets for diagnosing dialysis patients with heart failure.",2024,10.3389/fcvm.2024.1442238,https://pubmed.ncbi.nlm.nih.gov/39844908/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,39814554,Roles of the CDCA gene family in breast carcinoma.,2025,10.1177/00368504241312305,https://pubmed.ncbi.nlm.nih.gov/39814554/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,38181024,Integrated bioinformatics analysis and experimental validation identified CDCA families as prognostic biomarkers and sensitive indicators for rapamycin treatment of glioma.,2024,10.1371/journal.pone.0295346,https://pubmed.ncbi.nlm.nih.gov/38181024/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,35372372,Increased CDCA2 Level Was Related to Poor Prognosis in Hepatocellular Carcinoma and Associated With Up-Regulation of Immune Checkpoints.,2021,10.3389/fmed.2021.773724,https://pubmed.ncbi.nlm.nih.gov/35372372/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,40273626,"Vitamin K2 mitigates cognitive, and motor impairments induced by multiple surgery with anesthesia and analgesia in neonatal stage.",2025,10.1016/j.bbrc.2025.151784,https://pubmed.ncbi.nlm.nih.gov/40273626/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,40824549,Mitochondrial fission genes MTFP1/MTFP2 as predictive biomarkers in prostate cancer: a mendelian randomization study.,2025,10.1007/s12672-025-03215-6,https://pubmed.ncbi.nlm.nih.gov/40824549/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,34660326,Identification of CDCA2 as a Diagnostic and Prognostic Marker for Hepatocellular Carcinoma.,2021,10.3389/fonc.2021.755814,https://pubmed.ncbi.nlm.nih.gov/34660326/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,38863714,Integrated bioinformatics combined with machine learning to analyze shared biomarkers and pathways in psoriasis and cervical squamous cell carcinoma.,2024,10.3389/fimmu.2024.1351908,https://pubmed.ncbi.nlm.nih.gov/38863714/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA2,ENSG00000184661,Unsafe,16492807,Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability.,2006,10.1083/jcb.200508154,https://pubmed.ncbi.nlm.nih.gov/16492807/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,41699006,"Dysregulated expression of cell cycle regulators CDC20, PLK1, BUB1, CDC45, CDCA5 in pancreatic ductal adenocarcinoma.",2026,10.1038/s41598-026-37399-w,https://pubmed.ncbi.nlm.nih.gov/41699006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,42829577,Identification of a Novel Subtype-Derived Prognostic Signature Based on Nucleotide Metabolism-Related Molecular Classification for Predicting Lung Adenocarcinoma Prognosis.,2026,10.1155/ijog/4944325,https://pubmed.ncbi.nlm.nih.gov/42829577/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,41026320,CDCA5 knockdown potentiates olaparib sensitivity in BRCA1-mutated ovarian cancer through autophagy activation.,2025,10.1007/s12672-025-03610-z,https://pubmed.ncbi.nlm.nih.gov/41026320/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,39907709,E2F1-Dependent CDCA5 overexpression drives cervical cancer progression and correlates with poor prognosis.,2025,10.1007/s10735-025-10356-z,https://pubmed.ncbi.nlm.nih.gov/39907709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,42181770,Integrative circRNA landscape of intrauterine adhesions: putative ceRNA axes and circRNA-associated splicing usage linked to contractility and immunity.,2026,10.3389/fmolb.2026.1763980,https://pubmed.ncbi.nlm.nih.gov/42181770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,42059593,"The synaptonemal complex: structure, function, and clinical implications†.",2026,10.1093/biolre/ioag092,https://pubmed.ncbi.nlm.nih.gov/42059593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,41588542,Development and validation of gene expression-based signature for high-grade serous ovarian cancer.,2026,10.1186/s13048-026-01989-z,https://pubmed.ncbi.nlm.nih.gov/41588542/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,38978058,CDCA5 accelerates progression of breast cancer by promoting the binding of E2F1 and FOXM1.,2024,10.1186/s12967-024-05443-w,https://pubmed.ncbi.nlm.nih.gov/38978058/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,38539247,CDCA5 promoted cell invasion and migration by activating TGF-β1 pathway in human ovarian cancer cells.,2024,10.1186/s13048-024-01393-5,https://pubmed.ncbi.nlm.nih.gov/38539247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,38213717,"Integrated Multi-omics Analyses Identify CDCA5 as a Novel Biomarker Associated with Alternative Splicing, Tumor Microenvironment, and Cell Proliferation in Colon Cancer Via Pan-cancer Analysis.",2024,10.7150/jca.91082,https://pubmed.ncbi.nlm.nih.gov/38213717/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,40563993,Identification of Biomarkers Co-Associated with Lactylation and Acetylation in Systemic Lupus Erythematosus.,2025,10.3390/biomedicines13061274,https://pubmed.ncbi.nlm.nih.gov/40563993/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,38658931,CDCA5-EEF1A1 interaction promotes progression of clear cell renal cell carcinoma by regulating mTOR signaling.,2024,10.1186/s12935-024-03330-4,https://pubmed.ncbi.nlm.nih.gov/38658931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,37287817,The Comprehensive Analysis Illustrates the Role of CDCA5 in Breast Cancer: An Effective Diagnosis and Prognosis Biomarker.,2023,10.1155/2023/7150141,https://pubmed.ncbi.nlm.nih.gov/37287817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,40155519,Berberine diminishes the malignant progression of non-small cell lung cancer cells by targeting CDCA5 and CCNA2.,2025,10.1007/s11418-025-01885-8,https://pubmed.ncbi.nlm.nih.gov/40155519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,38988558,Comprehensive molecular analyses and experimental validation of CDCAs with potential implications in kidney renal papillary cell carcinoma prognosis.,2024,10.1016/j.heliyon.2024.e33045,https://pubmed.ncbi.nlm.nih.gov/38988558/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,41446353,Discovery of Essential Genes as Possible Targets for Prostate Cancer Drug Development.,2025,10.1155/ijog/9236117,https://pubmed.ncbi.nlm.nih.gov/41446353/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,39747150,CDC40 suppression induces CDCA5 splicing defects and anti-proliferative effects in lung cancer cells.,2025,10.1038/s41598-024-83337-z,https://pubmed.ncbi.nlm.nih.gov/39747150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,38838437,The impact of CDCA5 expression on the immune microenvironment and its potential utility as a biomarker for PD-L1/PD-1 inhibitors in lung adenocarcinoma.,2024,10.1016/j.tranon.2024.102024,https://pubmed.ncbi.nlm.nih.gov/38838437/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,39814554,Roles of the CDCA gene family in breast carcinoma.,2025,10.1177/00368504241312305,https://pubmed.ncbi.nlm.nih.gov/39814554/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,41741910,Lapatinib-Loaded Glucose-Functionalized Silver Nanoparticles Enhance Efficacy in HER2-Positive Breast Cancer Cells and Modulate Survival-Associated Genes.,2026,10.1007/s11095-026-04056-w,https://pubmed.ncbi.nlm.nih.gov/41741910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,39354483,Decoding the immune microenvironment: unveiling CD8 + T cell-related biomarkers and developing a prognostic signature for personalized glioma treatment.,2024,10.1186/s12935-024-03517-9,https://pubmed.ncbi.nlm.nih.gov/39354483/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,36438022,Prognostic and Immunological Roles of Cell Cycle Regulator CDCA5 in Human Solid Tumors.,2022,10.2147/ijgm.s389275,https://pubmed.ncbi.nlm.nih.gov/36438022/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,35373420,Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway.,2022,10.1002/jcla.24396,https://pubmed.ncbi.nlm.nih.gov/35373420/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,39903352,Key oncogenes and candidate drugs for hepatitis-B-driven hepatocellular carcinoma progression.,2025,10.1007/s12672-025-01851-6,https://pubmed.ncbi.nlm.nih.gov/39903352/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,38721057,Hub gene identification and immune infiltration analysis in hepatocellular carcinoma: Computational approach.,2024,10.1007/s40203-024-00215-2,https://pubmed.ncbi.nlm.nih.gov/38721057/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,36004470,CDCA5 promotes the progression of breast cancer and serves as a potential prognostic biomarker.,2022,10.3892/or.2022.8387,https://pubmed.ncbi.nlm.nih.gov/36004470/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,38890649,"Finding key genes (UBE2T, KIF4A, CDCA3, and CDCA5) co-expressed in hepatitis, cirrhosis and hepatocellular carcinoma based on multiple bioinformatics techniques.",2024,10.1186/s12876-024-03288-7,https://pubmed.ncbi.nlm.nih.gov/38890649/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,40245179,Decoding the Role of CDCA Genes in Breast Cancer Progression: Insights From in Silico and Functional Assay.,2025,10.1111/ajco.14173,https://pubmed.ncbi.nlm.nih.gov/40245179/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA5,ENSG00000146670,Unsafe,38961054,DCAF15 control of cohesin dynamics sustains acute myeloid leukemia.,2024,10.1038/s41467-024-49882-x,https://pubmed.ncbi.nlm.nih.gov/38961054/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,42479720,CDCA8 regulates ATP5F1A protein stability and malignant phenotypes in wilms tumor cells: Prognostic implications and mechanistic insights.,2026,10.1371/journal.pone.0353696,https://pubmed.ncbi.nlm.nih.gov/42479720/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,41565643,INCENP and CDCA8 predict neoadjuvant chemotherapy response and outcomes in esophageal squamous cell carcinoma.,2026,10.1038/s41467-026-68371-x,https://pubmed.ncbi.nlm.nih.gov/41565643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,41091302,"Suppressing CDCA8/CDK1 improves oral squamous cell carcinoma by modulating proliferation, apoptosis, cell cycle and migration.",2025,10.1007/s12672-025-03648-z,https://pubmed.ncbi.nlm.nih.gov/41091302/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,42054276,YBX1 promotes the stemness and metastasis of NSCLC cells by promoting CDCA8 expression.,2026,10.4149/neo_2026_250911n384,https://pubmed.ncbi.nlm.nih.gov/42054276/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,41674779,"TMEM106C, BSG, COPE, CDCA8, KPNA2, LIG1, UQCRH, and CCT5: Predictive of Survival and Immunotherapy Resistance in Hepatocellular Carcinoma.",2026,10.1155/humu/1465989,https://pubmed.ncbi.nlm.nih.gov/41674779/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,42072775,Integrative Bioinformatic Analysis Identifies Key Genes Driving Breast Cancer Brain Metastasis.,2026,10.3390/diagnostics16081149,https://pubmed.ncbi.nlm.nih.gov/42072775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,42002994,USP35 Acts as a Dual Stabilizer of CDCA8 and PD-L1 to Coordinate the Progression and Immune Evasion in Non-Small Cell Lung Cancer.,2026,10.2174/0113862073477780260415051730,https://pubmed.ncbi.nlm.nih.gov/42002994/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,42483195,Efferocytosis-associated Mrc1&lt;sup&gt;+&lt;/sup&gt;Gas6&lt;sup&gt;+&lt;/sup&gt; macrophages are linked to abdominal aortic aneurysm progression through ERK-associated dysfunction.,2026,10.3389/fimmu.2026.1863507,https://pubmed.ncbi.nlm.nih.gov/42483195/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,41546483,HAUS1 Promotes Colorectal Cancer Progression by Activating CDCA8 Transcription Through the HAUS1-EZH2-E2F1 Axis.,2026,10.1096/fj.202502095r,https://pubmed.ncbi.nlm.nih.gov/41546483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,41357242,Significance of SUMOylation in breast cancer progression: a comprehensive investigation using single-cell analysis and bioinformatics.,2025,10.3389/fimmu.2025.1675874,https://pubmed.ncbi.nlm.nih.gov/41357242/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,42031958,A macrophage MHC-I axis links intratumoral heterogeneity to terminal CD8&lt;sup&gt;+&lt;/sup&gt; T cell exhaustion in lung adenocarcinoma.,2026,10.1038/s41698-026-01446-6,https://pubmed.ncbi.nlm.nih.gov/42031958/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,39516785,Overexpression of CDCA8 predicts poor prognosis and drug insensitivity in lung adenocarcinoma.,2024,10.1186/s12920-024-02019-x,https://pubmed.ncbi.nlm.nih.gov/39516785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,41284119,The analysis of TOP2A as a potential target for predicting the prognosis of brain glioma in the TCGA database and in single-center study.,2025,10.1007/s12672-025-04051-4,https://pubmed.ncbi.nlm.nih.gov/41284119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,41646605,"The Effect of Preeclampsia on the Cell Adhesion, Migration, and Proliferation Potential of Human Umbilical Cord-Derived Mesenchymal Stem Cells.",2026,10.7759/cureus.100783,https://pubmed.ncbi.nlm.nih.gov/41646605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,41008819,&lt;i&gt;CDCA8&lt;/i&gt; and &lt;i&gt;TROAP&lt;/i&gt; as Prognostic Biomarkers of Postoperative Metastatic Progression in Clear Cell Renal Cell Carcinoma.,2025,10.3390/cancers17182975,https://pubmed.ncbi.nlm.nih.gov/41008819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,41496017,"WGCNA and machine learning identify AURKA, CDK1, and other hub genes associated with immune infiltration as therapeutic targets in GIST: An integrative bioinformatics analysis.",2026,10.1097/md.0000000000046636,https://pubmed.ncbi.nlm.nih.gov/41496017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,40465781,Identification of key genes and signaling pathways of liver cancer and model construction for prognosis and diagnosis based on bioinformatics analysis.,2025,10.1371/journal.pone.0325610,https://pubmed.ncbi.nlm.nih.gov/40465781/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,41373021,"A core stemness-associated module reveals PLK1, NUF2, KIF23, CDCA8, TOP2A, CENPF, AURKA, and ASPM as key genes in rectal cancer.",2025,10.1186/s40001-025-03649-2,https://pubmed.ncbi.nlm.nih.gov/41373021/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,36898512,A 1-kb human CDCA8 promoter directs the spermatogonia-specific luciferase expression in adult testis.,2023,10.1016/j.gene.2023.147350,https://pubmed.ncbi.nlm.nih.gov/36898512/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,41579174,Sex-dependent transcriptional responses and druggable targets in gentamicin-induced nephrotoxicity.,2026,10.1007/s00210-026-04997-4,https://pubmed.ncbi.nlm.nih.gov/41579174/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,41090158,Orally available decitabine prodrug OR-2100 induces mitotic perturbation for the treatment of double-hit lymphoma.,2025,10.1016/j.bneo.2025.100155,https://pubmed.ncbi.nlm.nih.gov/41090158/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,41257940,Prognostic modeling and immune infiltration analysis in hepatocellular carcinoma using glutathione metabolism-associated genes.,2025,10.1186/s40001-025-03403-8,https://pubmed.ncbi.nlm.nih.gov/41257940/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,40996677,Identification of immunosuppressive CD4&lt;sup&gt;+&lt;/sup&gt; T-cell subtype and construction of prognostic model for hepatocellular carcinoma.,2025,10.1007/s12672-025-03556-2,https://pubmed.ncbi.nlm.nih.gov/40996677/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,39814554,Roles of the CDCA gene family in breast carcinoma.,2025,10.1177/00368504241312305,https://pubmed.ncbi.nlm.nih.gov/39814554/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,38961953,The correlation between the MYBL2/CDCA8 signaling pathway of malignant melanoma.,2024,10.1016/j.heliyon.2024.e32485,https://pubmed.ncbi.nlm.nih.gov/38961953/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,39528802,Discovery of key molecular signatures for diagnosis and therapies of glioblastoma by combining supervised and unsupervised learning approaches.,2024,10.1038/s41598-024-79391-2,https://pubmed.ncbi.nlm.nih.gov/39528802/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,37813876,CDCA8 promotes bladder cancer survival by stabilizing HIF1α expression under hypoxia.,2023,10.1038/s41419-023-06189-x,https://pubmed.ncbi.nlm.nih.gov/37813876/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,41184881,HROB is a novel prognostic biomarker correlated with immune cell infiltration and tumor progression in lung adenocarcinoma.,2025,10.1186/s12957-025-04070-z,https://pubmed.ncbi.nlm.nih.gov/41184881/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,39072983,The liquid-liquid phase separation signature predicts the prognosis and immunotherapy response in hepatocellular carcinoma.,2024,10.1111/jcmm.18446,https://pubmed.ncbi.nlm.nih.gov/39072983/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,38463578,"CDCA8, a mitosis-related gene, as a prospective pan-cancer biomarker: implications for survival prognosis and oncogenic immunology.",2024,10.62347/wsef7878,https://pubmed.ncbi.nlm.nih.gov/38463578/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDCA8,ENSG00000134690,Unsafe,40178670,PBK as a novel biomarker performed excellent diagnostic and prognostic value in HCC associated with immune infiltration and methylation.,2025,10.1007/s10735-024-10324-z,https://pubmed.ncbi.nlm.nih.gov/40178670/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,41882177,CDK12/CDK13 inhibition disrupts transcriptional elongation and replication fork progression in glioblastoma.,2026,10.1038/s44321-026-00393-w,https://pubmed.ncbi.nlm.nih.gov/41882177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,42115719,High expression of the underexplored SLC4A11 protein-coding transcript is specific to the corneal endothelium.,2026,10.1038/s41598-026-51987-w,https://pubmed.ncbi.nlm.nih.gov/42115719/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,42839123,Inhibition of CDK12/CDK13-CYCLIN K rewires P-TEFb signaling to reverse HIV-1 latency and modulate cellular gene expression.,2026,10.1038/s44321-026-00536-z,https://pubmed.ncbi.nlm.nih.gov/42839123/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,41680470,CDK13 drives clear cell renal carcinoma through METTL16-mediated m&lt;sup&gt;6&lt;/sup&gt;A modification of ACLY mRNA.,2026,10.1038/s12276-025-01634-7,https://pubmed.ncbi.nlm.nih.gov/41680470/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,41896991,Sex differences in congenital hereditary endothelial dystrophy (CHED) and Slc4a11&lt;sup&gt;-/-&lt;/sup&gt; mouse model of CHED.,2026,10.1186/s13293-026-00879-9,https://pubmed.ncbi.nlm.nih.gov/41896991/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,41997449,Phosphorylation of RBM39 by CDK13 stabilizes RAD50 mRNA to drive cisplatin resistance in endometrial cancer.,2026,10.1016/j.jbc.2026.111447,https://pubmed.ncbi.nlm.nih.gov/41997449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,41850243,Targeted AAV6 gene therapy restores corneal endothelial function in three hereditary corneal dystrophies.,2026,10.1016/j.xcrm.2026.102649,https://pubmed.ncbi.nlm.nih.gov/41850243/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,42376960,Inhibition of cyclin-dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation.,2026,10.1002/1878-0261.70290,https://pubmed.ncbi.nlm.nih.gov/42376960/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,41809205,"Congenital Hereditary Endothelial Dystrophy: A Review of the Molecular Pathogenesis, Genetic Basis, and Emerging Treatments.",2026,10.2147/opth.s553795,https://pubmed.ncbi.nlm.nih.gov/41809205/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,41491919,CDK12 and CDK13 in oncology: from RNA regulation to therapeutic targeting.,2026,10.1007/s13402-025-01131-z,https://pubmed.ncbi.nlm.nih.gov/41491919/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,41896195,Inactivation of CDK12 Enhances Mitochondrial Efficiency to Suppress DNA Damage.,2026,10.1111/jcmm.71101,https://pubmed.ncbi.nlm.nih.gov/41896195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,38066173,Correction: CDK13-related disorder: a deep characterization of speech and language abilities and addition of 33 novel cases.,2026,10.1038/s41431-023-01515-5,https://pubmed.ncbi.nlm.nih.gov/38066173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,39556044,Cyclin-dependent kinase 13 is indispensable for normal mouse heart development.,2025,10.1111/joa.14175,https://pubmed.ncbi.nlm.nih.gov/39556044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,42653225,Complete SLC4A11 Detection in Saudi Congenital Hereditary Endothelial Dystrophy: A Transmembrane Glycine Hotspot and a Recurrent Splice Donor Allele in Consanguineous Patients.,2026,10.3390/ijms27167220,https://pubmed.ncbi.nlm.nih.gov/42653225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,42397909,Cyclin K condensates bridge CDK12 to phosphorylate and drive oncogenic YAP activation in hepatocellular carcinoma.,2026,10.1126/sciadv.aec6492,https://pubmed.ncbi.nlm.nih.gov/42397909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,42686681,CDK12/13 inhibition overcomes platinum resistance by impairing RNA metabolism.,2026,10.1038/s41392-026-02932-w,https://pubmed.ncbi.nlm.nih.gov/42686681/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,38511331,Early embryogenesis in CHDFIDD mouse model reveals facial clefts and altered cranial neurogenesis.,2024,10.1242/dmm.050261,https://pubmed.ncbi.nlm.nih.gov/38511331/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,40504161,Defining CDK12 as a tumor suppressor and therapeutic target in mouse models of tubo-ovarian high-grade serous carcinoma.,2025,10.1073/pnas.2426909122,https://pubmed.ncbi.nlm.nih.gov/40504161/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,42270604,CDK10 loss primes tumor cells for transcriptional vulnerability and sensitizes to CDK12/13 inhibition.,2026,10.1038/s41419-026-08973-x,https://pubmed.ncbi.nlm.nih.gov/42270604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,39971730,CDK13-Related Disorder: Novel Insights From A Series of 27 Cases and Recommendations for Clinical Management.,2025,10.1111/cge.14726,https://pubmed.ncbi.nlm.nih.gov/39971730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,40955658,CDK12/13 inactivation triggers STING-mediated antitumor immunity in preclinical models.,2025,10.1172/jci193745,https://pubmed.ncbi.nlm.nih.gov/40955658/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,42445040,Discovery of CTX-439: A Potent and Selective CDK12 Inhibitor as a Prospective Anti-Cancer Drug.,2026,10.1021/acsmedchemlett.6c00138,https://pubmed.ncbi.nlm.nih.gov/42445040/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,40585357,Targeting CDK7/12/13 functional synergism reverses myofibroblast activation and ameliorates lung fibrosis.,2025,10.1016/j.isci.2025.112778,https://pubmed.ncbi.nlm.nih.gov/40585357/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,42625328,CDK12/13 Inhibition Induces DNA Hypomethylation and Sensitizes Cancer Cells to Compounds Targeting DNA-PK.,2026,10.1111/jcmm.71323,https://pubmed.ncbi.nlm.nih.gov/42625328/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,42021999,"Identification of novel therapeutic targets for liver fibrosis, cirrhosis, and hepatocellular carcinoma &lt;i&gt;via&lt;/i&gt; dual-omics analysis and preliminary exploration of regulatory mechanisms.",2025,10.5114/ceh.2025.155448,https://pubmed.ncbi.nlm.nih.gov/42021999/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,37164450,AR-A014418 regulates intronic polyadenylation and transcription of PD-L1 through inhibiting CDK12 and CDK13 in tumor cells.,2023,10.1136/jitc-2022-006483,https://pubmed.ncbi.nlm.nih.gov/37164450/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,39533070,Physiological and pathological roles of the transcriptional kinases CDK12 and CDK13 in the central nervous system.,2025,10.1038/s41418-024-01413-3,https://pubmed.ncbi.nlm.nih.gov/39533070/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,39321214,Synthetic Lethal Targeting of CDK12-Deficient Prostate Cancer with PARP Inhibitors.,2024,10.1158/1078-0432.ccr-23-3785,https://pubmed.ncbi.nlm.nih.gov/39321214/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,40706396,(R)-6-[N-(3-(4-chlorophenyl) propyl] derivative of (R)-roscovitine inhibits lung carcinoma progression via cyclin-dependent kinase suppression.,2025,10.1016/j.bmc.2025.118331,https://pubmed.ncbi.nlm.nih.gov/40706396/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDK13,ENSG00000065883,Unsafe,39616721,Cricket protein-based film containing Caralluma fimbriata extract-based nanoparticles for preservation of cheddar cheese.,2025,10.1016/j.ultsonch.2024.107167,https://pubmed.ncbi.nlm.nih.gov/39616721/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,39937856,Clear cell renal carcinoma essentially requires CDKL3 for oncogenesis.,2025,10.1073/pnas.2415244122,https://pubmed.ncbi.nlm.nih.gov/39937856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,40569051,CDKL3 Targets ATG5 to Exacerbate the Progression of Malignant Melanoma.,2025,10.1002/mc.70002,https://pubmed.ncbi.nlm.nih.gov/40569051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,38993199,CDKL3 is a promising biomarker for diagnosis and prognosis prediction in patients with hepatocellular carcinoma.,2024,10.3389/ebm.2024.10106,https://pubmed.ncbi.nlm.nih.gov/38993199/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,38562942,CDKL3 shapes immunosuppressive tumor microenvironment and initiates autophagy in esophageal cancer.,2024,10.3389/fimmu.2024.1295011,https://pubmed.ncbi.nlm.nih.gov/38562942/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,38963708,CDKL3 is a targetable regulator of cell cycle progression in cancers.,2024,10.1172/jci178428,https://pubmed.ncbi.nlm.nih.gov/38963708/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,39658857,HNF4α-CDKL3 axis restricts MASLD progression by targeting FoxO1 via noncanonical phosphorylation.,2025,10.1097/hep.0000000000001147,https://pubmed.ncbi.nlm.nih.gov/39658857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,36899018,Inhibition of CDKL3 downregulates STAT1 thus suppressing prostate cancer development.,2023,10.1038/s41419-023-05694-3,https://pubmed.ncbi.nlm.nih.gov/36899018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,34097336,Identification of CDKL3 as a critical regulator in development of glioma through regulating RRM2 and the JNK signaling pathway.,2021,10.1111/cas.15010,https://pubmed.ncbi.nlm.nih.gov/34097336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,36630073,CDKL3 Promotes Non-small Cell Lung Cancer by Suppressing Autophagy Via Activation of PI3K/Akt/mTOR Pathway.,2023,10.1007/s12033-023-00656-8,https://pubmed.ncbi.nlm.nih.gov/36630073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,39800017,5-Methylcytosine-modified circRNA-CCNL2 regulates vascular remdeling in hypoxic pulmonary hypertension through binding to FXR2.,2025,10.1016/j.ijbiomac.2025.139638,https://pubmed.ncbi.nlm.nih.gov/39800017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,36270774,Correction: CDKL3 promotes osteosarcoma progression by activating Akt/PKB.,2022,10.26508/lsa.202201656,https://pubmed.ncbi.nlm.nih.gov/36270774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,32974198,CDKL3 Targets ATG5 to Promote Carcinogenesis of Esophageal Squamous Cell Carcinoma.,2020,10.3389/fonc.2020.01602,https://pubmed.ncbi.nlm.nih.gov/32974198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,34427098,Cyclin-dependent kinase like 3 promotes triple-negative breast cancer progression via inhibiting the p53 signaling pathway.,2021,10.4149/neo_2021_210331n427,https://pubmed.ncbi.nlm.nih.gov/34427098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,34329837,Bone marrow mesenchymal stem cells-secreted exosomal microRNA-205-5p exerts inhibitory effect on the progression of liver cancer through regulating CDKL3.,2021,10.1016/j.prp.2021.153549,https://pubmed.ncbi.nlm.nih.gov/34329837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,32234750,CDKL3 promotes osteosarcoma progression by activating Akt/PKB.,2020,10.26508/lsa.202000648,https://pubmed.ncbi.nlm.nih.gov/32234750/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,33747897,Corrigendum: CDKL3 Targets ATG5 to Promote Carcinogenesis of Esophageal Squamous Cell Carcinoma.,2020,10.3389/fonc.2020.619438,https://pubmed.ncbi.nlm.nih.gov/33747897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,34469538,AC-motif: a DNA motif containing adenine and cytosine repeat plays a role in gene regulation.,2021,10.1093/nar/gkab728,https://pubmed.ncbi.nlm.nih.gov/34469538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,30387188,Increased CDKL3 expression predicts poor prognosis and enhances malignant phenotypes in esophageal squamous cell carcinoma.,2019,10.1002/jcb.27991,https://pubmed.ncbi.nlm.nih.gov/30387188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,29615928,Curcumol Exerts Anticancer Effect in Cholangiocarcinoma Cells via Down-Regulating CDKL3.,2018,10.3389/fphys.2018.00234,https://pubmed.ncbi.nlm.nih.gov/29615928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,33232736,CircTP53 promotes colorectal cancer by acting as a miR-876-3p sponge to increase cyclin-dependent kinase-like 3 expression.,2021,10.1016/j.cellsig.2020.109845,https://pubmed.ncbi.nlm.nih.gov/33232736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKL3,ENSG00000006837,Unsafe,25815777,"cDNA microarray analysis of the effect of cantharidin on DNA damage, cell cycle and apoptosis-associated gene expression in NCI-H460 human lung cancer cells in vitro.",2015,10.3892/mmr.2015.3538,https://pubmed.ncbi.nlm.nih.gov/25815777/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,42425091,Identification of novel genes with enriched expression in human intermediate progenitors reveals a key role for CDKN3 in cortical development.,2026,10.1016/j.stemcr.2026.103012,https://pubmed.ncbi.nlm.nih.gov/42425091/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,42861842,Deguelin Alleviates Renal Tubular Epithelial Cell Injury in Lupus Nephritis by Inhibiting the PI3K/Akt Signaling Pathway.,2026,10.1177/1540658x261494333,https://pubmed.ncbi.nlm.nih.gov/42861842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,41876816,An estrogen receptor/E2F1/CDKN3 axis protects from UV-induced skin cancers in females.,2026,10.1038/s44319-026-00743-2,https://pubmed.ncbi.nlm.nih.gov/41876816/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,42396591,Identification of genes associated with cervical intervertebral disc degeneration and immune cell infiltration.,2026,10.3389/fsurg.2026.1798328,https://pubmed.ncbi.nlm.nih.gov/42396591/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,42638932,"&lt;i&gt;CDKN3&lt;/i&gt;, &lt;i&gt;PKP2&lt;/i&gt;, &lt;i&gt;ADM&lt;/i&gt;, &lt;i&gt;MS4A1&lt;/i&gt;, &lt;i&gt;FAM83A&lt;/i&gt;, and &lt;i&gt;DKK1&lt;/i&gt; Define a Posttranslational Modification (PTM)-Associated Prognostic Model for Lung Adenocarcinoma.",2026,10.1155/humu/3201577,https://pubmed.ncbi.nlm.nih.gov/42638932/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,42345518,MYBL2 Knockdown Enhances Ferroptosis and Bortezomib Sensitivity by Transcriptionally Regulating CDKN3 and Inactivating PI3K/Akt Signaling in Multiple Myeloma.,2026,10.1002/jbt.70990,https://pubmed.ncbi.nlm.nih.gov/42345518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,39838029,Identification of CDKN3 overexpression as a marker of poor prognosis and potential therapeutic target in low-grade glioma.,2025,10.1038/s41598-025-86338-8,https://pubmed.ncbi.nlm.nih.gov/39838029/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,40496041,Clinical significance of cyclin-dependent kinase inhibitor 3 in hepatocellular carcinoma.,2025,10.3892/mco.2025.2860,https://pubmed.ncbi.nlm.nih.gov/40496041/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,42472729,Bioinformatics reveals the prognostic potential of manganese metabolism-related genes in lung adenocarcinoma.,2026,10.1007/s10142-026-01982-1,https://pubmed.ncbi.nlm.nih.gov/42472729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,41731832,Identification and validation of paraptosis-related prognostic biomarkers in lung adenocarcinoma: An observational study based on transcriptomics and clinical outcomes.,2026,10.1097/md.0000000000047724,https://pubmed.ncbi.nlm.nih.gov/41731832/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,41207514,CDKN3 promoted triple-negative breast cancer by inhibiting ferroptosis through the upregulation of HSP90.,2026,10.1016/j.taap.2025.117629,https://pubmed.ncbi.nlm.nih.gov/41207514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,42709904,Graph neural network-based risk stratification of prostate cancer using gene expression and SHAP interpretability.,2026,10.1371/journal.pone.0356727,https://pubmed.ncbi.nlm.nih.gov/42709904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,39736853,MiR-192-5p targets cell cycle regulation in diabetic kidney disease via cyclin-dependent kinase inhibitor 3.,2025,10.1016/j.ncrna.2024.11.003,https://pubmed.ncbi.nlm.nih.gov/39736853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,38380029,The role of Cyclin Dependent Kinase Inhibitor 3 (CDKN3) in promoting human tumors: Literature review and pan-cancer analysis.,2024,10.1016/j.heliyon.2024.e26061,https://pubmed.ncbi.nlm.nih.gov/38380029/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,40294936,[High expression of CDKN3 promotes migration and invasion of gastric cancer cells by regulating the p53/NF-κB signaling pathway and inhibiting cell apoptosis].,2025,10.12122/j.issn.1673-4254.2025.04.21,https://pubmed.ncbi.nlm.nih.gov/40294936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,38720365,Human pan-cancer analysis of the predictive biomarker for the CDKN3.,2024,10.1186/s40001-024-01869-6,https://pubmed.ncbi.nlm.nih.gov/38720365/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,39806313,The systematic analysis of genes related to butyrate metabolism suggests that CDKN3 could serve as a promising therapeutic target for lung adenocarcinoma treatment.,2025,10.1186/s12885-024-13409-w,https://pubmed.ncbi.nlm.nih.gov/39806313/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,38106976,Comprehensive Analysis Reveals the Potential Roles of CDKN3 in Pancancer and Verification in Endometrial Cancer.,2023,10.2147/ijgm.s438479,https://pubmed.ncbi.nlm.nih.gov/38106976/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,40302936,Identification and verification of international neuroblastoma staging system (INSS) stage-related genes as potential biomarkers for neuroblastoma prognostic models.,2025,10.3389/fcell.2025.1502380,https://pubmed.ncbi.nlm.nih.gov/40302936/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,42305471,The flavonoid astragalin induces apoptosis in lung adenocarcinoma and correlates with a prognostic cell cycle gene signature associated with PANoptosis.,2026,10.21037/tcr-2026-1-0150,https://pubmed.ncbi.nlm.nih.gov/42305471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,40800177,Novel endoplasmic reticulum stress-related gene signature unveils CDKN3 as a prognosticator in neuroblastoma.,2025,10.21037/tp-2025-142,https://pubmed.ncbi.nlm.nih.gov/40800177/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,41480895,Design and Development of DNA Damage Chemical Inducers of Proximity for Targeted Cancer Therapy.,2026,10.1021/jacs.5c17396,https://pubmed.ncbi.nlm.nih.gov/41480895/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,41803177,Pilot degradation study of gamma irradiated ciprofloxacin in its primary packaging material for space pharmaceutical applications.,2026,10.1038/s41598-026-37307-2,https://pubmed.ncbi.nlm.nih.gov/41803177/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,39580329,"Corrigendum to ""Integrative analysis of anoikis-related genes prognostic signature with immunotherapy and identification of CDKN3 as a key oncogene in lung adenocarcinoma"" [ Int. Immunopharmacol. 143 (2024) 113282].",2024,10.1016/j.intimp.2024.113584,https://pubmed.ncbi.nlm.nih.gov/39580329/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,39383787,Integrative analysis of anoikis-related genes prognostic signature with immunotherapy and identification of CDKN3 as a key oncogene in lung adenocarcinoma.,2024,10.1016/j.intimp.2024.113282,https://pubmed.ncbi.nlm.nih.gov/39383787/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,40155682,Bioinformatic analysis of glycolysis and lactate metabolism genes in head and neck squamous cell carcinoma.,2025,10.1038/s41598-025-94843-z,https://pubmed.ncbi.nlm.nih.gov/40155682/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,41490727,Constructing a PANoptosis-based prognostic signature to evaluate the immune landscape and therapeutic response in clear cell renal cell carcinoma.,2025,10.1631/jzus.b2400132,https://pubmed.ncbi.nlm.nih.gov/41490727/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,41200217,DOCK3 orchestrates metastasis and immune microenvironment in prostate cancer.,2025,10.3389/fruro.2025.1662692,https://pubmed.ncbi.nlm.nih.gov/41200217/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,41837482,A Lactylation-based Gene Signature in Lung Adenocarcinoma Provides a Novel Perspective to Predict the Prognosis and Therapeutic Response.,2026,10.2174/0109298673433855251202003730,https://pubmed.ncbi.nlm.nih.gov/41837482/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDKN3,ENSG00000100526,Unsafe,40169794,"Integrating single-cell RNA sequencing, WGCNA, and machine learning to identify key biomarkers in hepatocellular carcinoma.",2025,10.1038/s41598-025-95493-x,https://pubmed.ncbi.nlm.nih.gov/40169794/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDRT4,ENSG00000239704,Unsafe,37152992,Transcriptomic insights into adenoid cystic carcinoma via RNA sequencing.,2023,10.3389/fgene.2023.1144945,https://pubmed.ncbi.nlm.nih.gov/37152992/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDRT4,ENSG00000239704,Unsafe,37463833,Landscape of semi-extractable RNAs across five human cell lines.,2023,10.1093/nar/gkad567,https://pubmed.ncbi.nlm.nih.gov/37463833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDRT4,ENSG00000239704,Unsafe,35672711,Synergistic anti-proliferative activity of JQ1 and GSK2801 in triple-negative breast cancer.,2022,10.1186/s12885-022-09690-2,https://pubmed.ncbi.nlm.nih.gov/35672711/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CDRT4,ENSG00000239704,Unsafe,11381029,The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes.,2001,10.1101/gr.180401,https://pubmed.ncbi.nlm.nih.gov/11381029/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,41068253,Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.,2025,10.1038/s41598-025-19223-z,https://pubmed.ncbi.nlm.nih.gov/41068253/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,42113045,Fecal miRNome and Proteome Profiling Uncovers Stage-Specific Biomarkers of Alzheimer's Disease in 3×Tg-AD Mice.,2026,10.1007/s10571-026-01735-5,https://pubmed.ncbi.nlm.nih.gov/42113045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,41079267,Leonurine Alleviates DSS-Induced Colitis in Mice by Regulating Pancreatic Secretion Pathway and Gut Microbiota.,2025,10.1155/jimr/6626309,https://pubmed.ncbi.nlm.nih.gov/41079267/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,41187819,Catalytically active hCELA3B is a natively-folded monomer and is N-glycosylated.,2026,10.1016/j.pep.2025.106840,https://pubmed.ncbi.nlm.nih.gov/41187819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,37379306,CELA3B immunostaining is a highly specific marker for acinar cell carcinoma of the pancreas.,2023,10.1371/journal.pone.0287528,https://pubmed.ncbi.nlm.nih.gov/37379306/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,41271441,Electrophysiological and Proteomic Evidence of Protease-Mediated Pro-nociceptive Signaling in Inflammatory Bowel Disease Patients.,2026,10.1523/jneurosci.0220-25.2025,https://pubmed.ncbi.nlm.nih.gov/41271441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,35773178,Loss-of-function variant in chymotrypsin like elastase 3B (CELA3B) is associated with non-alcoholic chronic pancreatitis.,2022,10.1016/j.pan.2022.06.258,https://pubmed.ncbi.nlm.nih.gov/35773178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,37976327,Gene communities in co-expression networks across different tissues.,2023,10.1371/journal.pcbi.1011616,https://pubmed.ncbi.nlm.nih.gov/37976327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,37894145,Enzymatic Cleavage of Stx2a in the Gut and Identification of Pancreatic Elastase and Trypsin as Possible Main Cleavers.,2023,10.3390/microorganisms11102487,https://pubmed.ncbi.nlm.nih.gov/37894145/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,37769343,Splicing transcriptome-wide association study to identify splicing events for pancreatic cancer risk.,2023,10.1093/carcin/bgad069,https://pubmed.ncbi.nlm.nih.gov/37769343/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,31917448,A Transcriptome-Wide Association Study Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer.,2020,10.1093/jnci/djz246,https://pubmed.ncbi.nlm.nih.gov/31917448/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,28360028,Detection of human elastase isoforms by the ScheBo Pancreatic Elastase 1 Test.,2017,10.1152/ajpgi.00060.2017,https://pubmed.ncbi.nlm.nih.gov/28360028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,37103765,LncRNA Regulation Mechanism in Hepatic Alveolar Echinococcosis with Nanosecond Pulse.,2023,10.1007/s11686-023-00672-3,https://pubmed.ncbi.nlm.nih.gov/37103765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,31369399,Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma.,2019,10.1172/jci129961,https://pubmed.ncbi.nlm.nih.gov/31369399/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,28062577,Overlapping Specificity of Duplicated Human Pancreatic Elastase 3 Isoforms and Archetypal Porcine Elastase 1 Provides Clues to Evolution of Digestive Enzymes.,2017,10.1074/jbc.m116.770560,https://pubmed.ncbi.nlm.nih.gov/28062577/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,35106523,Transcriptome analysis provides insight into the anti-diabetic mechanism of theaflavins in high-fat diet and streptozotocin-induced mice.,2022,10.1039/d1fo03856g,https://pubmed.ncbi.nlm.nih.gov/35106523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,32458105,Insights into Dietary Switch in Cetaceans: Evidence from Molecular Evolution of Proteinases and Lipases.,2020,10.1007/s00239-020-09952-2,https://pubmed.ncbi.nlm.nih.gov/32458105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,27999401,Genetic Analysis of Human Chymotrypsin-Like Elastases 3A and 3B (CELA3A and CELA3B) to Assess the Role of Complex Formation between Proelastases and Procarboxypeptidases in Chronic Pancreatitis.,2016,10.3390/ijms17122148,https://pubmed.ncbi.nlm.nih.gov/27999401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,28257494,Domestication drive the changes of immune and digestive system of Eurasian perch (Perca fluviatilis).,2017,10.1371/journal.pone.0172903,https://pubmed.ncbi.nlm.nih.gov/28257494/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,31579405,Identification of a 3-mRNA signature as a novel potential prognostic biomarker in patients with ovarian serous cystadenocarcinoma in G2 and G3.,2019,10.3892/ol.2019.10701,https://pubmed.ncbi.nlm.nih.gov/31579405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,31832568,A Pilot Genome-Wide Analysis Study Identifies Loci Associated With Response to Obeticholic Acid in Patients With NASH.,2019,10.1002/hep4.1439,https://pubmed.ncbi.nlm.nih.gov/31832568/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,26171222,"Identification of activating enzymes of a novel FBPase inhibitor prodrug, CS-917.",2015,10.1002/prp2.138,https://pubmed.ncbi.nlm.nih.gov/26171222/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CELA3B,ENSG00000219073,Unsafe,10620133,Human elastase 1: evidence for expression in the skin and the identification of a frequent frameshift polymorphism.,2000,10.1046/j.1523-1747.2000.00825.x,https://pubmed.ncbi.nlm.nih.gov/10620133/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,42716419,"Bufalin targets CENPA-modulated glycolysis via PI3K/AKT in hepatocellular carcinoma: A bioinformatics, In Vitro and preliminary In Vivo evidence.",2026,10.1016/j.mce.2026.112907,https://pubmed.ncbi.nlm.nih.gov/42716419/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,42589710,A β-Hydroxybutyrylation-FOXM1/CENPA Axis Links Ketone-Body Metabolism to Mitotic Transcription in Basal-like Breast Cancer.,2026,10.3390/ijms27157059,https://pubmed.ncbi.nlm.nih.gov/42589710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,42206268,CENPA as a Genome Stability-Associated Biomarker in Hepatocellular Carcinoma: Multiomics Analysis and Experimental Validation.,2026,10.1155/humu/9292971,https://pubmed.ncbi.nlm.nih.gov/42206268/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,41914289,CENPA Promotes Endometrial Cancer Progression by Stabilizing YY1 and Enhancing Glycolytic Metabolism.,2026,10.31083/fbl49033,https://pubmed.ncbi.nlm.nih.gov/41914289/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,42720822,IGF2BP3 enhances paclitaxel resistance in bladder urothelial carcinoma by recognizing m&lt;sup&gt;6&lt;/sup&gt;A-modified CENPA mRNA.,2026,10.1007/s12032-026-03383-7,https://pubmed.ncbi.nlm.nih.gov/42720822/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,42913007,Loss of KAT5-dependent H2A.Z acetylation provokes chromosomal instability in recurrent pregnancy loss.,2026,10.1126/sciadv.aef6029,https://pubmed.ncbi.nlm.nih.gov/42913007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,41378098,"Radiotherapy and precision medicine's role in molecular alterations during chromosomal division: The influence of &lt;i&gt;MB, TP53, CENPA, BUB1B&lt;/i&gt;, &lt;i&gt;MAD2L1&lt;/i&gt;, &lt;i&gt;ZWINT&lt;/i&gt; expression and noncoding RNAs in oral cancer.",2025,10.1016/j.bbrep.2025.102376,https://pubmed.ncbi.nlm.nih.gov/41378098/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,41589308,Identification of IGF2BP3 and CENPA as key regulators of immunophenotypes in renal clear cell carcinoma.,2025,10.3389/fgene.2025.1749780,https://pubmed.ncbi.nlm.nih.gov/41589308/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,42763899,Immune cell enrichment characteristics and related key genes in intrauterine adhesion: insights from RNA-sequencing analysis.,2026,10.1080/19396368.2026.2731896,https://pubmed.ncbi.nlm.nih.gov/42763899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,41935051,EBNA1BP2 (EBP2) promotes the progression of hepatocellular carcinoma through upregulating the expression of MCM8 and HMGB1.,2026,10.1038/s41419-026-08671-8,https://pubmed.ncbi.nlm.nih.gov/41935051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,39820192,Single-cell and bulk RNA sequencing analysis reveals CENPA as a potential biomarker and therapeutic target in cancers.,2025,10.1371/journal.pone.0314745,https://pubmed.ncbi.nlm.nih.gov/39820192/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,42384816,Remote homology and functional genetics unmask deeply preserved Scm3/HJURP orthologs in metazoans.,2026,10.1126/sciadv.aeg5356,https://pubmed.ncbi.nlm.nih.gov/42384816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,39620895,Exploration of the biological mechanisms of CENPA as an oncogene in glioma: Screening based on cancer functional status.,2024,10.1111/jcmm.70181,https://pubmed.ncbi.nlm.nih.gov/39620895/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,41402347,Unravelling TPX2-centered co-expression networks as key drivers of aggressive prostate cancer.,2025,10.1038/s41598-025-27704-4,https://pubmed.ncbi.nlm.nih.gov/41402347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,41351017,A cross-tissue transcriptome-wide association study identifies novel candidate genes associated with brain glymphatic system function.,2025,10.1186/s13041-025-01258-y,https://pubmed.ncbi.nlm.nih.gov/41351017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,41826988,Development of a G2/M checkpoint subtype classifier for guiding precision therapy in liver hepatocellular carcinoma patients.,2026,10.1186/s12935-026-04237-y,https://pubmed.ncbi.nlm.nih.gov/41826988/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,41425594,Advancing breast cancer biomarkers: a centromere-related gene signature integrated with single-cell analysis for prognostic prediction.,2025,10.3389/fimmu.2025.1678603,https://pubmed.ncbi.nlm.nih.gov/41425594/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,40235876,Centromere protein A knockdown inhibits rectal cancer through O6-methylguanine DNA methyltransferase/protein tyrosine phosphatase nonreceptor type 4 axis.,2025,10.4251/wjgo.v17.i4.102619,https://pubmed.ncbi.nlm.nih.gov/40235876/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,42080449,Dysregulation of microRNAs and Centromere Protein Genes in Prostate Cancer and Metastatic Progression.,2026,10.5152/tud.2026.26143,https://pubmed.ncbi.nlm.nih.gov/42080449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,40618443,CENPA-driven transcriptional activation of ECT2 enhances EGFR inhibitor resistance in lung adenocarcinoma.,2025,10.1016/j.bbrc.2025.152287,https://pubmed.ncbi.nlm.nih.gov/40618443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,41735402,Development of a CT radiomics and clinical feature combined model for predicting early recurrence of surgical resected hepatocellular carcinoma.,2026,10.1038/s41598-026-40130-4,https://pubmed.ncbi.nlm.nih.gov/41735402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,41252712,Lactylation-Related Gene Signature and Immune Infiltration Crosstalk in Heart Failure: Insights From Bulk and Single-Cell Transcriptomics.,2026,10.1097/fjc.0000000000001775,https://pubmed.ncbi.nlm.nih.gov/41252712/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,42147811,Integrating Bulk and Single-Cell RNA-Seq Reveals Glycolysis-Associated Macrophages and Its Related Tumor Subgroup Signatures to Predict Prognosis and Therapy in Clear Cell Renal Cell Carcinoma.,2026,10.1155/humu/3125551,https://pubmed.ncbi.nlm.nih.gov/42147811/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,39487313,Dysregulation of R-loop homeostasis shapes the immunosuppressive microenvironment and induces malignant progression in melanoma.,2025,10.1007/s10495-024-02039-z,https://pubmed.ncbi.nlm.nih.gov/39487313/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,40804263,"Suppressive effects of Momordica charantia MAP30 on the senescence, proliferation and migration of bladder cancer cells mediated by CENPA.",2025,10.1038/s41598-025-14977-y,https://pubmed.ncbi.nlm.nih.gov/40804263/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,39456925,Establishment and Verification of a Novel Gene Signature Connecting Hypoxia and Lactylation for Predicting Prognosis and Immunotherapy of Pancreatic Ductal Adenocarcinoma Patients by Integrating Multi-Machine Learning and Single-Cell Analysis.,2024,10.3390/ijms252011143,https://pubmed.ncbi.nlm.nih.gov/39456925/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,41751958,FOXM1 Signaling Network Transcriptionally Upregulates Expression of Proteins Involved in Mitotic Progression to Induce High Proliferation and Chromosomal Instability in Androgen Receptor-Low Triple-Negative Breast Cancer.,2026,10.3390/ijms27041823,https://pubmed.ncbi.nlm.nih.gov/41751958/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,36341103,CENPA acts as a prognostic factor that relates to immune infiltrates in gliomas.,2022,10.3389/fneur.2022.1015221,https://pubmed.ncbi.nlm.nih.gov/36341103/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,39966861,G2M-checkpoint related immune barrier structure and signature for prognosis and immunotherapy response in hepatocellular carcinoma: insights from spatial transcriptome and machine learning.,2025,10.1186/s12967-024-06051-4,https://pubmed.ncbi.nlm.nih.gov/39966861/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,40717368,Effect of Sacubitril-Valsartan on Transcriptomic Changes in Lung Tissue of Spontaneously Hypertensive Rats: A Multi-omics Study Based on RNA-Seq Transcriptome Analysis.,2026,10.1093/ajh/hpaf143,https://pubmed.ncbi.nlm.nih.gov/40717368/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPA,ENSG00000115163,Unsafe,37928273,CENPA functions as a transcriptional regulator to promote hepatocellular carcinoma progression via cooperating with YY1.,2023,10.7150/ijbs.85656,https://pubmed.ncbi.nlm.nih.gov/37928273/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,41607031,"Mechanistic Investigation of Nitidine Chloride-Mediated Anti-Colorectal Cancer Activity: Centromere-Associated Protein E Targeting via Integrated Molecular Dynamics, Spatial Transcriptomic and Single-Cell Approaches.",2026,10.1049/syb2.70054,https://pubmed.ncbi.nlm.nih.gov/41607031/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,41472935,Identification and Validation of the Prognostic Value of PTTG1-Related Genes in Hepatocellular Carcinoma by Mendelian Randomization and Single-Cell Transcriptome Analysis.,2026,10.30498/ijb.2025.543634.4221,https://pubmed.ncbi.nlm.nih.gov/41472935/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,40794013,The Transcription Factor CREB1 Triggers the Progression of Clear Cell Renal Cell Carcinoma by Promoting CENPE Expression.,2025,10.1111/jcmm.70773,https://pubmed.ncbi.nlm.nih.gov/40794013/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,41885686,The Postnatal Lung Maturation Disrupted by Increased Pulmonary Blood Flow and Its Clinical Implications.,2026,10.1016/j.jacasi.2026.02.013,https://pubmed.ncbi.nlm.nih.gov/41885686/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,40608414,Mutations in the spliceosomal gene SNW1 cause neurodevelopment disorders with microcephaly.,2025,10.1172/jci186119,https://pubmed.ncbi.nlm.nih.gov/40608414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,40401507,The Overexpression of Collagen Receptor DDR1 is Associated With Chromosome Instability and Aneuploidy in Diffuse Large B-Cell Lymphoma.,2025,10.1111/jcmm.70318,https://pubmed.ncbi.nlm.nih.gov/40401507/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,39759304,CENPE is a diagnostic and prognostic biomarker for cervical cancer.,2024,10.1016/j.heliyon.2024.e40860,https://pubmed.ncbi.nlm.nih.gov/39759304/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,38702677,Analyzing the expression and clinical significance of CENPE in gastric cancer.,2024,10.1186/s12920-024-01887-7,https://pubmed.ncbi.nlm.nih.gov/38702677/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,42635880,Immune-related gene signature for predicting biochemical recurrence after RP in prostate cancer subtypes.,2026,10.1007/s12672-026-05623-8,https://pubmed.ncbi.nlm.nih.gov/42635880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,42551718,An oxidative stress - and immunotherapy-related six-gene signature defines immune subtypes and predicts prognosis and immunotherapy response in hepatocellular carcinoma.,2026,10.1016/j.gene.2026.150335,https://pubmed.ncbi.nlm.nih.gov/42551718/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,42076055,"Mitotic Machinery Dysregulation in Lung Cancer: Biological Roles, Therapeutic Targeting, and Combination Strategies.",2026,10.3390/pharmaceutics18040402,https://pubmed.ncbi.nlm.nih.gov/42076055/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,41125711,Sleep recovery alleviates impaired glucose tolerance induced by sleep fragmentation possibly through gut microbiota in mice.,2025,10.1038/s41598-025-20862-5,https://pubmed.ncbi.nlm.nih.gov/41125711/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,39512467,RNAs m6A modification facilitates UVB-induced photoaging.,2024,10.1016/j.heliyon.2024.e39532,https://pubmed.ncbi.nlm.nih.gov/39512467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,41673397,M&lt;sup&gt;5&lt;/sup&gt;C-driven stabilization of SERPINB5 promotes cervical cancer progression and chemotherapy resistance.,2026,10.1038/s41419-026-08453-2,https://pubmed.ncbi.nlm.nih.gov/41673397/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,39327243,PCGF2 Acts as an Oncogenic Driver in Colon Cancer through the Upregulation of CENPE.,2024,10.24976/discov.med.202436188.166,https://pubmed.ncbi.nlm.nih.gov/39327243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,37593739,Primary microcephaly gene CENPE is a novel biomarker and potential therapeutic target for non-WNT/non-SHH medulloblastoma.,2023,10.3389/fimmu.2023.1227143,https://pubmed.ncbi.nlm.nih.gov/37593739/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,39331093,KIF18A promotes cervical squamous cell carcinoma progression by activating the PI3K/AKT pathway through upregulation of CENPE.,2024,10.3233/cbm-240074,https://pubmed.ncbi.nlm.nih.gov/39331093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,41882697,SIRT1 haploinsufficiency recapitulates age-associated subfertility through sperm α-tubulin hyperacetylation.,2026,10.1186/s13062-025-00710-2,https://pubmed.ncbi.nlm.nih.gov/41882697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,41160214,The immune infiltration and prognostic significance of complement and coagulation cascade-related genes in lung adenocarcinoma.,2025,10.1007/s12672-025-03765-9,https://pubmed.ncbi.nlm.nih.gov/41160214/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,42524029,Transcriptomic differences in chromatin and cell cycle regulation in A549 cells after irradiation with carbon ions and X-rays.,2026,10.3389/fonc.2026.1869974,https://pubmed.ncbi.nlm.nih.gov/42524029/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,38258067,Maximizing Anticancer Response with MPS1 and CENPE Inhibition Alongside Apoptosis Induction.,2023,10.3390/pharmaceutics16010056,https://pubmed.ncbi.nlm.nih.gov/38258067/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,37925501,CENPE and LDHA were potential prognostic biomarkers of chromophobe renal cell carcinoma.,2023,10.1186/s40001-023-01449-0,https://pubmed.ncbi.nlm.nih.gov/37925501/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,38486758,The platelet-related genes associated with the prognosis of HCC by regulating cycling T cell and prolif-TAMs.,2024,10.1016/j.heliyon.2024.e26798,https://pubmed.ncbi.nlm.nih.gov/38486758/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,37479754,ATAD2 is a driver and a therapeutic target in ovarian cancer that functions by upregulating CENPE.,2023,10.1038/s41419-023-05993-9,https://pubmed.ncbi.nlm.nih.gov/37479754/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,40408617,Bioinformatics and system biology approach to discover the common pathogenetic processes between COVID-19 and chronic hepatitis B.,2025,10.1371/journal.pone.0323708,https://pubmed.ncbi.nlm.nih.gov/40408617/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,38431072,"Effects of environmentally relevant concentration of short-chain chlorinated paraffins on BV2 microglia activation and lipid metabolism, implicating altered neurogenesis.",2024,10.1016/j.envres.2024.118602,https://pubmed.ncbi.nlm.nih.gov/38431072/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPE,ENSG00000138778,Unsafe,38875410,SPAG5 and ASPM play important roles in gastric cancer: An observational study.,2024,10.1097/md.0000000000038499,https://pubmed.ncbi.nlm.nih.gov/38875410/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,42696959,A chemoresistance-associated proliferation gene signature identified by single-cell and machine learning analysis predicts prognosis in high-grade serous ovarian carcinoma.,2026,10.1016/j.tranon.2026.103018,https://pubmed.ncbi.nlm.nih.gov/42696959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,42407379,Shared genetic regulators and diagnostic biomarkers in gallbladder stone and cholangiocarcinoma: A comprehensive comparative transcriptomic analysis.,2026,10.1016/j.tranon.2026.102901,https://pubmed.ncbi.nlm.nih.gov/42407379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,39831256,Comprehensive bioinformatics analysis of prognosis and immunotherapy in lung adenocarcinoma.,2024,10.21037/jtd-24-1530,https://pubmed.ncbi.nlm.nih.gov/39831256/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,41863163,Classifying Molecular Subtypes and Establishing a Prognosis Model using Oxidative Stress-related Genes for Lung Adenocarcinoma.,2026,10.2174/0109298673423335251226131133,https://pubmed.ncbi.nlm.nih.gov/41863163/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,37293159,"CENPH overexpression promotes the progression, cisplatin resistance, and poor prognosis of lung adenocarcinoma via the AKT and ERK/P38 pathways.",2023,,https://pubmed.ncbi.nlm.nih.gov/37293159/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,37328854,Predicting tumor repopulation through the gene panel derived from radiation resistant colorectal cancer cells.,2023,10.1186/s12967-023-04260-x,https://pubmed.ncbi.nlm.nih.gov/37328854/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,36801676,The predictive value of plasma exosomal lncRNAs/mRNAs in NSCLC patients receiving immunotherapy.,2023,10.1016/j.advms.2023.01.003,https://pubmed.ncbi.nlm.nih.gov/36801676/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,36915596,A five-gene expression signature of centromeric proteins with prognostic value in lung adenocarcinoma.,2023,10.21037/tcr-22-2166,https://pubmed.ncbi.nlm.nih.gov/36915596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,37004005,Bioinformatic analysis highlights SNHG6 as a putative prognostic biomarker for kidney renal papillary cell carcinoma.,2023,10.1186/s12894-023-01218-5,https://pubmed.ncbi.nlm.nih.gov/37004005/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,37547464,TFRC-RNA interactions show the regulation of gene expression and alternative splicing associated with IgAN in human renal tubule mesangial cells.,2023,10.3389/fgene.2023.1176118,https://pubmed.ncbi.nlm.nih.gov/37547464/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,28819418,CENPH Inhibits Rapamycin Sensitivity by Regulating GOLPH3-dependent mTOR Signaling Pathway in Colorectal Cancer.,2017,10.7150/jca.19940,https://pubmed.ncbi.nlm.nih.gov/28819418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,34631307,A four-gene prognostic signature for predicting the overall survival of patients with lung adenocarcinoma.,2021,10.7717/peerj.11911,https://pubmed.ncbi.nlm.nih.gov/34631307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,34798483,Prognostic model of lung adenocarcinoma constructed by the CENPA complex genes is closely related to immune infiltration.,2021,10.1016/j.prp.2021.153680,https://pubmed.ncbi.nlm.nih.gov/34798483/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,27993978,CenpH regulates meiotic G2/M transition by modulating the APC/CCdh1-cyclin B1 pathway in oocytes.,2017,10.1242/dev.141135,https://pubmed.ncbi.nlm.nih.gov/27993978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,26248586,Upregulation of centromere protein H is associated with progression of renal cell carcinoma.,2015,10.1007/s10735-015-9635-2,https://pubmed.ncbi.nlm.nih.gov/26248586/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,33564675,Microarray Data Mining and Preliminary Bioinformatics Analysis of Hepatitis D Virus-Associated Hepatocellular Carcinoma.,2021,10.1155/2021/1093702,https://pubmed.ncbi.nlm.nih.gov/33564675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,33005492,Identification of NUF2 and FAM83D as potential biomarkers in triple-negative breast cancer.,2020,10.7717/peerj.9975,https://pubmed.ncbi.nlm.nih.gov/33005492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,33198934,Impact of genetic polymorphisms in kinetochore and spindle assembly genes on chromosomal aberration frequency in healthy humans.,2020,10.1016/j.mrgentox.2020.503253,https://pubmed.ncbi.nlm.nih.gov/33198934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,22682030,Sp1 and Sp3 are involved in the full transcriptional activity of centromere protein H in human nasopharyngeal carcinoma cells.,2012,10.1111/j.1742-4658.2012.08654.x,https://pubmed.ncbi.nlm.nih.gov/22682030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,30662724,Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma.,2018,10.1098/rsos.181006,https://pubmed.ncbi.nlm.nih.gov/30662724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,23071473,Identification of genes underlying different methylation profiles in refractory anemia with excess blast and refractory cytopenia with multilineage dysplasia in myelodysplastic syndrome.,2012,10.5045/kjh.2012.47.3.186,https://pubmed.ncbi.nlm.nih.gov/23071473/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPH,ENSG00000153044,Unsafe,25099028,"Down-regulation of Sp1 suppresses cell proliferation, clonogenicity and the expressions of stem cell markers in nasopharyngeal carcinoma.",2014,10.1186/s12967-014-0222-1,https://pubmed.ncbi.nlm.nih.gov/25099028/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,42124320,Centromere protein I promotes hepatocellular carcinoma progression by activating PI3K/AKT/mTOR-CDK2 cascade.,2026,10.1080/15384047.2026.2667596,https://pubmed.ncbi.nlm.nih.gov/42124320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,41206587,FOXM1/CENPI axis regulation of proline and arginine metabolism in glioblastoma cells.,2026,10.1093/jnen/nlaf121,https://pubmed.ncbi.nlm.nih.gov/41206587/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,41074145,Centromere protein I facilitates breast cancer tumorigenesis and disease progression through modulation of Wnt/β-Catenin signaling.,2025,10.1186/s12935-025-04001-8,https://pubmed.ncbi.nlm.nih.gov/41074145/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,41273532,CENPI Promotes the Progression in Oral Squamous Cell Carcinoma and Is Regulated by E2F4.,2026,10.1007/s12013-025-01938-5,https://pubmed.ncbi.nlm.nih.gov/41273532/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,41473255,"Centromere Protein I, a Cell Cycle Checkpoint Gene, Accelerates Tumor Progression via the Hippo Pathway and Mediates Immune Escape in Hepatocellular Carcinoma.",2025,10.14218/jcth.2025.00127,https://pubmed.ncbi.nlm.nih.gov/41473255/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,40406242,The m&lt;sup&gt;6&lt;/sup&gt;A reader YTHDF3 promotes TNBC progression by regulating CENPI stabilization.,2025,10.3389/fonc.2025.1546723,https://pubmed.ncbi.nlm.nih.gov/40406242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,40784804,[CENPI promotes the migration of liver cancer cells and the epithelial-mesenchymal transition process by activating the RAS/MEK/ERK signaling axis].,2025,10.3760/cma.j.cn501113-20231110-00189,https://pubmed.ncbi.nlm.nih.gov/40784804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,39932629,Genetic insights into non-obstructive azoospermia: Implications for diagnosis and TESE outcomes.,2025,10.1007/s10815-025-03409-5,https://pubmed.ncbi.nlm.nih.gov/39932629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,40202151,Bioinformatics Combined With Biological Experiments to Identify the Pathogenetic Link of Type 2 Diabetes for Breast Cancer.,2025,10.1002/cam4.70759,https://pubmed.ncbi.nlm.nih.gov/40202151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,38886359,A novel blood-based epigenetic biosignature in first-episode schizophrenia patients through automated machine learning.,2024,10.1038/s41398-024-02946-4,https://pubmed.ncbi.nlm.nih.gov/38886359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,42035708,Genotoxic effects of 6PPD-quinone on juvenile European seabass (Dicentrarchus labrax): Impacts on DNA replication fidelity and oxidative DNA damage.,2026,10.1016/j.aquatox.2026.107830,https://pubmed.ncbi.nlm.nih.gov/42035708/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,42137124,Colon cancer versus colitis: a microRNA and gene expression analysis via system biology tools.,2025,10.22037/ghfbb.v18ispecialissue.3262,https://pubmed.ncbi.nlm.nih.gov/42137124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,40983188,Evaluation of the association between sex-linked genes and treatment response in lung cancer.,2025,10.1016/j.radonc.2025.111159,https://pubmed.ncbi.nlm.nih.gov/40983188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,37465344,Pan-Cancer Analysis Reveals CENPI as a Potential Biomarker and Therapeutic Target in Adrenocortical Carcinoma.,2023,10.2147/jir.s408358,https://pubmed.ncbi.nlm.nih.gov/37465344/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,38232915,Immune infiltration related CENPI associates with the malignant features and drug resistance of lung adenocarcinoma.,2024,10.1016/j.bbadis.2024.167017,https://pubmed.ncbi.nlm.nih.gov/38232915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,36035209,Identification and Validation of Three Hub Genes Involved in Cell Proliferation and Prognosis of Castration-Resistant Prostate Cancer.,2022,10.1155/2022/8761112,https://pubmed.ncbi.nlm.nih.gov/36035209/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,38176630,Identification of the hub genes linked to zearalenone-induced hepatotoxicity in broiler chickens.,2024,10.1016/j.envres.2023.118094,https://pubmed.ncbi.nlm.nih.gov/38176630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,28977935,Overexpression of the E2F target gene CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer.,2017,10.18632/oncotarget.19131,https://pubmed.ncbi.nlm.nih.gov/28977935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,35496042,Upregulation of Centromere Proteins as Potential Biomarkers for Esophageal Squamous Cell Carcinoma Diagnosis and Prognosis.,2022,10.1155/2022/3758731,https://pubmed.ncbi.nlm.nih.gov/35496042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,29936263,CENPI is overexpressed in colorectal cancer and regulates cell migration and invasion.,2018,10.1016/j.gene.2018.06.067,https://pubmed.ncbi.nlm.nih.gov/29936263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,29976630,Effects of Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response.,2018,10.21873/cgp.20083,https://pubmed.ncbi.nlm.nih.gov/29976630/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPI,ENSG00000102384,Unsafe,25479423,Accounting for eXentricities: analysis of the X chromosome in GWAS reveals X-linked genes implicated in autoimmune diseases.,2014,10.1371/journal.pone.0113684,https://pubmed.ncbi.nlm.nih.gov/25479423/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,41797275,Zeylenone Attenuates Tamoxifen Resistance by Directly Binding to CTCF and Inhibiting the CTCF-CENPK-JAK1/STAT3 Signaling Axis in Breast Cancer.,2026,10.1002/ddr.70255,https://pubmed.ncbi.nlm.nih.gov/41797275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,39404386,The Role of CENPK Splice Variant in Abiraterone Response in Metastatic Castration-Resistant Prostate Cancer.,2024,10.3390/cells13191622,https://pubmed.ncbi.nlm.nih.gov/39404386/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,42589442,MicroRNA Signatures of Fulvestrant-Treated Luminal Breast Cancer Cells: Identification of Therapeutic Targets Regulated by &lt;i&gt;miR-374b-5p&lt;/i&gt;.,2026,10.3390/ijms27156787,https://pubmed.ncbi.nlm.nih.gov/42589442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,39617260,Centromere protein K enhances the activation of YAP1/TAZ signal cascade to drive the progression of clear cell renal cell carcinoma.,2025,10.1016/j.taap.2024.117181,https://pubmed.ncbi.nlm.nih.gov/39617260/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,42137124,Colon cancer versus colitis: a microRNA and gene expression analysis via system biology tools.,2025,10.22037/ghfbb.v18ispecialissue.3262,https://pubmed.ncbi.nlm.nih.gov/42137124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,36312839,Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A.,2022,10.3748/wjg.v28.i37.5420,https://pubmed.ncbi.nlm.nih.gov/36312839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,38670220,CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated activation of mTOR signaling.,2024,10.1016/j.mce.2024.112253,https://pubmed.ncbi.nlm.nih.gov/38670220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,40500570,Machine learning and bioinformatics analysis to identify and validate diagnostic model associated with immune infiltration in rheumatoid arthritis.,2025,10.1007/s10067-025-07514-9,https://pubmed.ncbi.nlm.nih.gov/40500570/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,38919957,Uncovering periodontitis-associated markers through the aggregation of transcriptomics information from diverse sources.,2024,10.3389/fgene.2024.1398582,https://pubmed.ncbi.nlm.nih.gov/38919957/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,33904381,Overexpression of centromere protein K (CENPK) gene in Differentiated Thyroid Carcinoma promote cell Proliferation and Migration.,2021,10.1080/21655979.2021.1911533,https://pubmed.ncbi.nlm.nih.gov/33904381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,35035680,Pan-cancer investigation of CENPK gene: clinical significance and oncogenic immunology.,2021,,https://pubmed.ncbi.nlm.nih.gov/35035680/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,35706799,The cell cycle gene centromere protein K (CENPK) contributes to the malignant progression and prognosis of prostate cancer.,2022,10.21037/tcr-21-2164,https://pubmed.ncbi.nlm.nih.gov/35706799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,35418160,N6-methyladenosine modification of CENPK mRNA by ZC3H13 promotes cervical cancer stemness and chemoresistance.,2022,10.1186/s40779-022-00378-z,https://pubmed.ncbi.nlm.nih.gov/35418160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,34382342,Knockdown of CENPK inhibits cell growth and facilitates apoptosis via PTEN-PI3K-AKT signalling pathway in gastric cancer.,2021,10.1111/jcmm.16850,https://pubmed.ncbi.nlm.nih.gov/34382342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,36089000,The inhibition of centromere protein K causes anticancer effects in breast carcinoma via effects on the FAK/PI3K/AKT/mTOR pathway.,2022,10.1016/j.taap.2022.116232,https://pubmed.ncbi.nlm.nih.gov/36089000/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,39323031,Comprehensive Analysis Identifies Hyaluronan Mediated Motility Receptor and Cell Division Cycle 25C as Potential Prognostic Biomarkers in Head and Neck Squamous Cell Carcinoma.,2024,10.1177/10732748241287904,https://pubmed.ncbi.nlm.nih.gov/39323031/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,35715658,Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5.,2022,10.1007/s10120-022-01311-y,https://pubmed.ncbi.nlm.nih.gov/35715658/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,34044826,LINC01158 works as an oncogene in glioma via sponging miR-6734-3p to boost CENPK expression.,2021,10.1186/s12935-021-01931-x,https://pubmed.ncbi.nlm.nih.gov/34044826/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,40074128,Bulk transcriptome and single-nucleus RNA sequencing analyses highlight the role of recombination activating 1 in non-alcoholic fatty liver disease.,2025,10.1016/j.ijbiomac.2025.141919,https://pubmed.ncbi.nlm.nih.gov/40074128/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,33478508,Bioinformatics analysis combined with experiments predicts CENPK as a potential prognostic factor for lung adenocarcinoma.,2021,10.1186/s12935-021-01760-y,https://pubmed.ncbi.nlm.nih.gov/33478508/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,37605423,Identification of Stem Cell-related Gene Markers by Comprehensive Transcriptome Analysis to Predict the Prognosis and Immunotherapy of Lung Adenocarcinoma.,2024,10.2174/1574888x18666230821104844,https://pubmed.ncbi.nlm.nih.gov/37605423/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,34719665,Identification of Potential Prognostic and Predictive Biomarkers for Immune-Checkpoint Inhibitor Response in Small Cell Lung Cancer.,2021,10.12659/msm.932275,https://pubmed.ncbi.nlm.nih.gov/34719665/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,37938151,A robust six-gene prognostic signature based on two prognostic subtypes constructed by chromatin regulators is correlated with immunological features and therapeutic response in lung adenocarcinoma.,2023,10.18632/aging.205183,https://pubmed.ncbi.nlm.nih.gov/37938151/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,37370088,"Promoter hypermethylation and comprehensive regulation of ncRNA lead to the down-regulation of ZNF880, providing a new insight for the therapeutics and research of colorectal cancer.",2023,10.1186/s12920-023-01571-2,https://pubmed.ncbi.nlm.nih.gov/37370088/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,33046735,Transcriptional characterization of conjunctival melanoma identifies the cellular tumor microenvironment and prognostic gene signatures.,2020,10.1038/s41598-020-72864-0,https://pubmed.ncbi.nlm.nih.gov/33046735/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,21176163,Whole genome sequencing of Saccharomyces cerevisiae: from genotype to phenotype for improved metabolic engineering applications.,2010,10.1186/1471-2164-11-723,https://pubmed.ncbi.nlm.nih.gov/21176163/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,20844758,"Claudin 13, a member of the claudin family regulated in mouse stress induced erythropoiesis.",2010,10.1371/journal.pone.0012667,https://pubmed.ncbi.nlm.nih.gov/20844758/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPK,ENSG00000123219,Unsafe,8950979,"Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia.",1996,,https://pubmed.ncbi.nlm.nih.gov/8950979/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPL,ENSG00000120334,Unsafe,41847349,SP1 lactylation promotes endometrial cancer cell stemness via regulation of CENPL expression.,2026,10.1016/j.gendis.2025.101962,https://pubmed.ncbi.nlm.nih.gov/41847349/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPL,ENSG00000120334,Unsafe,41927050,Functional characterization of porcine septin12 and its role in male reproduction.,2026,10.5713/ab.250538,https://pubmed.ncbi.nlm.nih.gov/41927050/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPL,ENSG00000120334,Unsafe,39628712,KDM1A-mediated ZFP64 demethylation activates CENPL to promote epithelial ovarian cancer progression.,2025,10.1007/s10616-024-00671-w,https://pubmed.ncbi.nlm.nih.gov/39628712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPL,ENSG00000120334,Unsafe,39507047,"Role of CENPL, DARS2, and PAICS in determining the prognosis of patients with lung adenocarcinoma.",2024,10.21037/tlcr-24-696,https://pubmed.ncbi.nlm.nih.gov/39507047/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPL,ENSG00000120334,Unsafe,41751958,FOXM1 Signaling Network Transcriptionally Upregulates Expression of Proteins Involved in Mitotic Progression to Induce High Proliferation and Chromosomal Instability in Androgen Receptor-Low Triple-Negative Breast Cancer.,2026,10.3390/ijms27041823,https://pubmed.ncbi.nlm.nih.gov/41751958/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPL,ENSG00000120334,Unsafe,37914022,"CENPL accelerates cell proliferation, cell cycle, apoptosis, and glycolysis via the MEK1/2-ERK1/2 pathway in hepatocellular carcinoma.",2024,10.1016/j.biocel.2023.106481,https://pubmed.ncbi.nlm.nih.gov/37914022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPL,ENSG00000120334,Unsafe,42358573,1q25.3-q32.1 deletion causing multisystem developmental delay: a case report and literature review.,2026,10.3389/fped.2026.1774631,https://pubmed.ncbi.nlm.nih.gov/42358573/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPL,ENSG00000120334,Unsafe,36816951,Highly expressed CENPL is correlated with breast cancer cell proliferation and immune infiltration.,2023,10.3389/fonc.2023.1046774,https://pubmed.ncbi.nlm.nih.gov/36816951/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPL,ENSG00000120334,Unsafe,36572856,Overexpression of CENPL mRNA potentially regulated by miR-340-3p predicts the prognosis of pancreatic cancer patients.,2022,10.1186/s12885-022-10450-5,https://pubmed.ncbi.nlm.nih.gov/36572856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPL,ENSG00000120334,Unsafe,35844598,Pan-Cancer and Single-Cell Analysis Reveals CENPL as a Cancer Prognosis and Immune Infiltration-Related Biomarker.,2022,10.3389/fimmu.2022.916594,https://pubmed.ncbi.nlm.nih.gov/35844598/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPL,ENSG00000120334,Unsafe,41357226,Gene signature for response prediction to immunotherapy and prognostic markers in metastatic urothelial carcinoma.,2025,10.3389/fimmu.2025.1607222,https://pubmed.ncbi.nlm.nih.gov/41357226/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPL,ENSG00000120334,Unsafe,34457090,High mRNA Expression of CENPL and Its Significance in Prognosis of Hepatocellular Carcinoma Patients.,2021,10.1155/2021/9971799,https://pubmed.ncbi.nlm.nih.gov/34457090/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPL,ENSG00000120334,Unsafe,34607313,Highly expressed centromere protein L indicates adverse survival and associates with immune infiltration in hepatocellular carcinoma.,2021,10.18632/aging.203574,https://pubmed.ncbi.nlm.nih.gov/34607313/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPL,ENSG00000120334,Unsafe,34341433,"CENPL, ISG20L2, LSM4, MRPL3 are four novel hub genes and may serve as diagnostic and prognostic markers in breast cancer.",2021,10.1038/s41598-021-95068-6,https://pubmed.ncbi.nlm.nih.gov/34341433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPL,ENSG00000120334,Unsafe,34012666,The roles of the cell division cycle-associated gene family in hepatocellular carcinoma.,2021,10.21037/jgo-21-110,https://pubmed.ncbi.nlm.nih.gov/34012666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPL,ENSG00000120334,Unsafe,33062452,Loss of inner kinetochore genes is associated with the transition to an unconventional point centromere in budding yeast.,2020,10.7717/peerj.10085,https://pubmed.ncbi.nlm.nih.gov/33062452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPL,ENSG00000120334,Unsafe,21548129,Distinctive phenotype in 9 patients with deletion of chromosome 1q24-q25.,2011,10.1002/ajmg.a.34049,https://pubmed.ncbi.nlm.nih.gov/21548129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,41751958,FOXM1 Signaling Network Transcriptionally Upregulates Expression of Proteins Involved in Mitotic Progression to Induce High Proliferation and Chromosomal Instability in Androgen Receptor-Low Triple-Negative Breast Cancer.,2026,10.3390/ijms27041823,https://pubmed.ncbi.nlm.nih.gov/41751958/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,37061713,Pan-cancer landscape of CENPO and its underlying mechanism in LUAD.,2023,10.1186/s12931-023-02408-3,https://pubmed.ncbi.nlm.nih.gov/37061713/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,37558987,Prognostic and immune infiltrative biomarkers of CENPO in pan-cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis.,2023,10.1186/s12885-023-11233-2,https://pubmed.ncbi.nlm.nih.gov/37558987/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,36187159,CENPO is Associated with Immune Cell Infiltration and is a Potential Diagnostic and Prognostic Marker for Hepatocellular Carcinoma.,2022,10.2147/ijgm.s382234,https://pubmed.ncbi.nlm.nih.gov/36187159/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,37207381,Advances in lung adenocarcinoma: A novel perspective on prognoses and immune responses of CENPO as an oncogenic superenhancer.,2023,10.1016/j.tranon.2023.101691,https://pubmed.ncbi.nlm.nih.gov/37207381/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,39684488,Identification of Diagnostic and Prognostic Subnetwork Biomarkers for Women with Breast Cancer Using Integrative Genomic and Network-Based Analysis.,2024,10.3390/ijms252312779,https://pubmed.ncbi.nlm.nih.gov/39684488/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,37896902,Identification and Analysis of a Four-Gene Set for Diagnosing SFTS Virus Infection Based on Machine Learning Methods and Its Association with Immune Cell Infiltration.,2023,10.3390/v15102126,https://pubmed.ncbi.nlm.nih.gov/37896902/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,35201521,CENPO regulated proliferation and apoptosis of colorectal cancer in a p53-dependent manner.,2022,10.1007/s12672-022-00469-2,https://pubmed.ncbi.nlm.nih.gov/35201521/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,41272700,Bridging pharmacovigilance and genetic insight: investigating drugs and indications for breast cancer risk in women with autoimmune diseases.,2025,10.1186/s12967-025-07338-w,https://pubmed.ncbi.nlm.nih.gov/41272700/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,39543244,Enhancing risk stratification models in localized prostate cancer by novel validated tissue biomarkers.,2025,10.1038/s41391-024-00918-9,https://pubmed.ncbi.nlm.nih.gov/39543244/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,36107579,Gene mining of immune microenvironment in hepatocellular carcinoma.,2022,10.1097/md.0000000000030453,https://pubmed.ncbi.nlm.nih.gov/36107579/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,31485675,CENPO expression regulates gastric cancer cell proliferation and is associated with poor patient prognosis.,2019,10.3892/mmr.2019.10624,https://pubmed.ncbi.nlm.nih.gov/31485675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,33841571,High expression levels of centromere protein A plus upregulation of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling pathway affect chemotherapy response and prognosis in patients with breast cancer.,2021,10.3892/ol.2021.12671,https://pubmed.ncbi.nlm.nih.gov/33841571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,31545079,Analysis of Gene Expression in Bladder Cancer: Possible Involvement of Mitosis and Complement and Coagulation Cascades Signaling Pathway.,2020,10.1089/cmb.2019.0237,https://pubmed.ncbi.nlm.nih.gov/31545079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,28848385,Translational Identification of Transcriptional Signatures of Major Depression and Antidepressant Response.,2017,10.3389/fnmol.2017.00248,https://pubmed.ncbi.nlm.nih.gov/28848385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,35949842,Construction and validation of a novel prediction system for detection of overall survival in lung cancer patients.,2022,10.12998/wjcc.v10.i18.5984,https://pubmed.ncbi.nlm.nih.gov/35949842/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,31920381,Super-Enhancer-Associated Hub Genes In Chronic Myeloid Leukemia Identified Using Weighted Gene Co-Expression Network Analysis.,2019,10.2147/cmar.s214614,https://pubmed.ncbi.nlm.nih.gov/31920381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,28093568,GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.,2017,10.1038/mp.2016.244,https://pubmed.ncbi.nlm.nih.gov/28093568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,28977405,Genome-scale detection of positive selection in nine primates predicts human-virus evolutionary conflicts.,2017,10.1093/nar/gkx704,https://pubmed.ncbi.nlm.nih.gov/28977405/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,26334372,Exposure to fluorescent light triggers down regulation of genes involved with mitotic progression in Xiphophorus skin.,2015,10.1016/j.cbpc.2015.08.006,https://pubmed.ncbi.nlm.nih.gov/26334372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPO,ENSG00000138092,Unsafe,21980299,A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.,2011,10.1371/journal.pgen.1002293,https://pubmed.ncbi.nlm.nih.gov/21980299/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPP,ENSG00000188312,Unsafe,36071244,A novel nonsense variant in the CENPP gene segregates in a Swiss family with autosomal dominant low-frequency sensorineural hearing loss.,2022,10.1038/s41431-022-01184-w,https://pubmed.ncbi.nlm.nih.gov/36071244/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPP,ENSG00000188312,Unsafe,38238903,Enriched Single-Nucleus RNA-Sequencing Reveals Unique Attributes of Distal Convoluted Tubule Cells.,2024,10.1681/asn.0000000000000297,https://pubmed.ncbi.nlm.nih.gov/38238903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPP,ENSG00000188312,Unsafe,34268072,A nomogram based on CENPP expression for survival prediction in breast cancer.,2021,10.21037/gs-21-30,https://pubmed.ncbi.nlm.nih.gov/34268072/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPP,ENSG00000188312,Unsafe,37925772,Immunomodulatory effect of Atractylodis macrocephala Koidz. polysaccharides in vitro.,2024,10.1016/j.psj.2023.103171,https://pubmed.ncbi.nlm.nih.gov/37925772/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPP,ENSG00000188312,Unsafe,37649101,Fathers' preconception smoking and offspring DNA methylation.,2023,10.1186/s13148-023-01540-7,https://pubmed.ncbi.nlm.nih.gov/37649101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPP,ENSG00000188312,Unsafe,36457707,Exploring a four-gene risk model based on doxorubicin resistance-associated lncRNAs in hepatocellular carcinoma.,2022,10.3389/fphar.2022.1015842,https://pubmed.ncbi.nlm.nih.gov/36457707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPP,ENSG00000188312,Unsafe,34429772,CDK4 has the ability to regulate Aurora B and Cenpp expression in mouse keratinocytes.,2021,10.3892/ol.2021.12993,https://pubmed.ncbi.nlm.nih.gov/34429772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPP,ENSG00000188312,Unsafe,33362862,Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identifies Candidate Genes Associated With Idiopathic Pulmonary Fibrosis.,2020,10.3389/fgene.2020.604324,https://pubmed.ncbi.nlm.nih.gov/33362862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPP,ENSG00000188312,Unsafe,31047894,RAP-8 ameliorates liver fibrosis by modulating cell cycle and oxidative stress.,2019,10.1016/j.lfs.2019.04.037,https://pubmed.ncbi.nlm.nih.gov/31047894/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPP,ENSG00000188312,Unsafe,26334372,Exposure to fluorescent light triggers down regulation of genes involved with mitotic progression in Xiphophorus skin.,2015,10.1016/j.cbpc.2015.08.006,https://pubmed.ncbi.nlm.nih.gov/26334372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,42909385,EXO1 inhibition selectively kills replication repair-deficient cancer cells.,2026,10.1093/narcan/zcag029,https://pubmed.ncbi.nlm.nih.gov/42909385/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,35310916,hsa_circ_0077837 Alleviated the Malignancy of Non-Small Cell Lung Cancer by Regulating the miR-1178-3p/APITD1 Axis.,2022,10.1155/2022/3902832,https://pubmed.ncbi.nlm.nih.gov/35310916/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,35363173,A comprehensive investigation on pan-cancer impacts of constitutive centromere associated network gene family by integrating multi-omics data: A CONSORT-compliant article.,2022,10.1097/md.0000000000028821,https://pubmed.ncbi.nlm.nih.gov/35363173/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,36652992,The FANCC-FANCE-FANCF complex is evolutionarily conserved and regulates meiotic recombination.,2023,10.1093/nar/gkac1244,https://pubmed.ncbi.nlm.nih.gov/36652992/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,31836759,FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops.,2019,10.1038/s41598-019-55537-5,https://pubmed.ncbi.nlm.nih.gov/31836759/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,31855181,The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast.,2019,10.7554/elife.49784,https://pubmed.ncbi.nlm.nih.gov/31855181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,38948269,[Homozygous Variant of FANCM of the Fanconi Anemia Pathway Causes Premature Ovarian Insufficiency: Investigation of the Pathogenic Mechanism].,2024,10.12182/20240560207,https://pubmed.ncbi.nlm.nih.gov/38948269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,30022024,The concerted roles of FANCM and Rad52 in the protection of common fragile sites.,2018,10.1038/s41467-018-05066-y,https://pubmed.ncbi.nlm.nih.gov/30022024/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,23886707,Structural peculiarities of the (MHF1-MHF2)4 octamer provide a long DNA binding patch to anchor the MHF-FANCM complex to chromatin: a solution SAXS study.,2013,10.1016/j.febslet.2013.07.022,https://pubmed.ncbi.nlm.nih.gov/23886707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,33439149,Structural analysis of the chicken FANCM-MHF complex and its stability.,2021,10.1107/s2053230x20016003,https://pubmed.ncbi.nlm.nih.gov/33439149/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,20347429,"MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM.",2010,10.1016/j.molcel.2010.01.036,https://pubmed.ncbi.nlm.nih.gov/20347429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,24026537,MHF1-2/CENP-S-X performs distinct roles in centromere metabolism and genetic recombination.,2013,10.1098/rsob.130102,https://pubmed.ncbi.nlm.nih.gov/24026537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,15328517,"A novel 1p36.2 located gene, APITD1, with tumour-suppressive properties and a putative p53-binding domain, shows low expression in neuroblastoma tumours.",2004,10.1038/sj.bjc.6602083,https://pubmed.ncbi.nlm.nih.gov/15328517/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,24800743,The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins.,2014,10.1371/journal.pbio.1001856,https://pubmed.ncbi.nlm.nih.gov/24800743/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,22510687,The structure of the FANCM-MHF complex reveals physical features for functional assembly.,2012,10.1038/ncomms1779,https://pubmed.ncbi.nlm.nih.gov/22510687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,17962439,Expression of APITD1 is not related to copy number changes of chromosomal region 1p36 or the prognosis of uveal melanoma.,2007,10.1167/iovs.07-0061,https://pubmed.ncbi.nlm.nih.gov/17962439/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,28673972,"FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres.",2017,10.1073/pnas.1708065114,https://pubmed.ncbi.nlm.nih.gov/28673972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,27805868,Ovariectomy Alters Gene Expression of the Hippocampal Formation in Middle-Aged Rats.,2017,10.1210/en.2016-1516,https://pubmed.ncbi.nlm.nih.gov/27805868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,25240201,Differential contribution of the Fanconi anemia-related proteins to repair of several types of DNA damage in cultured silkworm cells.,2014,10.1016/j.febslet.2014.09.009,https://pubmed.ncbi.nlm.nih.gov/25240201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,15740626,"A cluster of genes located in 1p36 are down-regulated in neuroblastomas with poor prognosis, but not due to CpG island methylation.",2005,10.1186/1476-4598-4-10,https://pubmed.ncbi.nlm.nih.gov/15740626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPS-CORT,ENSG00000251503,Unsafe,23624835,Genetic and physical interactions between the yeast ELG1 gene and orthologs of the Fanconi anemia pathway.,2013,10.4161/cc.24756,https://pubmed.ncbi.nlm.nih.gov/23624835/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,41041859,CENPU promotes tumorigenesis and stem cell properties in triple‑negative breast cancer by suppressing lysosomal furin degradation.,2025,10.3892/ijmm.2025.5649,https://pubmed.ncbi.nlm.nih.gov/41041859/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,42168250,RRM2 as a biomarker and therapeutic target in letrozole resistant estrogen receptor positive breast cancer.,2026,10.1038/s41598-026-49012-1,https://pubmed.ncbi.nlm.nih.gov/42168250/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,40023134,Centromere protein U mediates the ubiquitination and degradation of RPS3 to facilitate temozolomide resistance in glioblastoma.,2025,10.1016/j.drup.2025.101214,https://pubmed.ncbi.nlm.nih.gov/40023134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,38988917,Overexpression of CENPU promotes cancer growth and metastasis and is associated with poor survival in patients with nasopharyngeal carcinoma.,2024,10.21037/tcr-23-2395,https://pubmed.ncbi.nlm.nih.gov/38988917/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,41220952,"Advances in glycolysis research in gastric cancer: molecular mechanisms, regulatory networks, and therapeutic potential.",2025,10.3389/fonc.2025.1678681,https://pubmed.ncbi.nlm.nih.gov/41220952/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,39299262,Identification and Characterization of Key Genes Associated with Amelogenesis.,2025,10.1055/s-0044-1787958,https://pubmed.ncbi.nlm.nih.gov/39299262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,40058474,DPHC from Alpinia officinarum Hance specifically modulates the function of CENPU in the cell cycle and apoptosis to ameliorate hepatocellular carcinoma.,2025,10.1016/j.jep.2025.119598,https://pubmed.ncbi.nlm.nih.gov/40058474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,38919957,Uncovering periodontitis-associated markers through the aggregation of transcriptomics information from diverse sources.,2024,10.3389/fgene.2024.1398582,https://pubmed.ncbi.nlm.nih.gov/38919957/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,36608638,Knockdown of CENPU inhibits cervical cancer cell migration and stemness through the FOXM1/Wnt/β-catenin pathway.,2023,10.1016/j.tice.2022.102009,https://pubmed.ncbi.nlm.nih.gov/36608638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,36647653,[Prognostic Value of the Expression of Myeloid Leukemia Factor 1-Interacting Protein in Gastric Cancer and Its Regulatory Role in Tumor Progression].,2023,10.12182/20230160103,https://pubmed.ncbi.nlm.nih.gov/36647653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,34957303,Abnormal Expression of Centromere Protein U Is Associated with Hepatocellular Cancer Progression.,2021,10.1155/2021/4051192,https://pubmed.ncbi.nlm.nih.gov/34957303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,35844791,A positive feedback loop of CENPU/E2F6/E2F1 facilitates proliferation and metastasis via ubiquitination of E2F6 in hepatocellular carcinoma.,2022,10.7150/ijbs.69495,https://pubmed.ncbi.nlm.nih.gov/35844791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,40646471,Genome-wide association studies and candidate genes networks affecting reproductive traits using Iranian Holstein sequence data.,2025,10.1186/s12864-025-11744-1,https://pubmed.ncbi.nlm.nih.gov/40646471/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,36073219,[Centromere protein U is highly expressed in colorectal cancer and associated with a poor long-term prognosis].,2022,10.12122/j.issn.1673-4254.2022.08.12,https://pubmed.ncbi.nlm.nih.gov/36073219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,35122991,Overexpression of MLF1IP promotes colorectal cancer cell proliferation through BRCA1/AKT/p27 signaling pathway.,2022,10.1016/j.cellsig.2022.110273,https://pubmed.ncbi.nlm.nih.gov/35122991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,34872447,Centromere protein U (CENPU) promotes gastric cancer cell proliferation and glycolysis by regulating high mobility group box 2 (HMGB2).,2021,10.1080/21655979.2021.2002018,https://pubmed.ncbi.nlm.nih.gov/34872447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,33902008,The lncRNA GATA3-AS1/miR-495-3p/CENPU axis predicts poor prognosis of breast cancer via the PLK1 signaling pathway.,2021,10.18632/aging.202909,https://pubmed.ncbi.nlm.nih.gov/33902008/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,36915596,A five-gene expression signature of centromeric proteins with prognostic value in lung adenocarcinoma.,2023,10.21037/tcr-22-2166,https://pubmed.ncbi.nlm.nih.gov/36915596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,37723560,Pan cancer characterization of genes whose expression has been associated with LINE-1 antisense promoter activity.,2023,10.1186/s13100-023-00300-x,https://pubmed.ncbi.nlm.nih.gov/37723560/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,33602882,Centromere protein U enhances the progression of bladder cancer by promoting mitochondrial ribosomal protein s28 expression.,2021,10.4196/kjpp.2021.25.2.119,https://pubmed.ncbi.nlm.nih.gov/33602882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,33816619,Molecular Mechanism of Secondary Endocrine Resistance in Luminal Breast Cancer.,2021,10.1155/2021/6618519,https://pubmed.ncbi.nlm.nih.gov/33816619/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,34798483,Prognostic model of lung adenocarcinoma constructed by the CENPA complex genes is closely related to immune infiltration.,2021,10.1016/j.prp.2021.153680,https://pubmed.ncbi.nlm.nih.gov/34798483/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,30588102,Centromere protein U expression promotes non-small-cell lung cancer cell proliferation through FOXM1 and predicts poor survival.,2018,10.2147/cmar.s182852,https://pubmed.ncbi.nlm.nih.gov/30588102/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,34457090,High mRNA Expression of CENPL and Its Significance in Prognosis of Hepatocellular Carcinoma Patients.,2021,10.1155/2021/9971799,https://pubmed.ncbi.nlm.nih.gov/34457090/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,40636569,Altered expression in liver cancer with various hepatic blood flow occlusions: A pilot RNA sequencing study.,2023,10.1016/j.iliver.2023.04.001,https://pubmed.ncbi.nlm.nih.gov/40636569/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,35363173,A comprehensive investigation on pan-cancer impacts of constitutive centromere associated network gene family by integrating multi-omics data: A CONSORT-compliant article.,2022,10.1097/md.0000000000028821,https://pubmed.ncbi.nlm.nih.gov/35363173/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,35028418,Promising novel biomarkers and candidate small-molecule drugs for lung adenocarcinoma: Evidence from bioinformatics analysis of high-throughput data.,2022,10.1515/med-2021-0375,https://pubmed.ncbi.nlm.nih.gov/35028418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,30598639,Analysis of dynamic molecular networks for pancreatic ductal adenocarcinoma progression.,2018,10.1186/s12935-018-0718-5,https://pubmed.ncbi.nlm.nih.gov/30598639/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,29955902,"Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone.",2018,10.1007/s00204-018-2250-8,https://pubmed.ncbi.nlm.nih.gov/29955902/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,29154753,Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability.,2017,10.7554/elife.29303,https://pubmed.ncbi.nlm.nih.gov/29154753/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,26513691,Selective blockade of cancer cell proliferation and anchorage-independent growth by Plk1 activity-dependent suicidal inhibition of its polo-box domain.,2015,10.1080/15384101.2015.1104435,https://pubmed.ncbi.nlm.nih.gov/26513691/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,15893739,Regulation of myeloid leukemia factor-1 interacting protein (MLF1IP) expression in glioblastoma.,2005,10.1016/j.brainres.2005.04.017,https://pubmed.ncbi.nlm.nih.gov/15893739/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,15116101,cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP.,2004,10.1038/sj.onc.1207448,https://pubmed.ncbi.nlm.nih.gov/15116101/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPU,ENSG00000151725,Unsafe,12941884,Identification of a novel cellular transcriptional repressor interacting with the latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus.,2003,10.1128/jvi.77.18.9758-9768.2003,https://pubmed.ncbi.nlm.nih.gov/12941884/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPVL1,ENSG00000223591,Unsafe,31555424,Further Clinical and Molecular Delineation of Xp11.22 Deletion Syndrome: A Case Report.,2019,10.5001/omj.2019.83,https://pubmed.ncbi.nlm.nih.gov/31555424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPVL1,ENSG00000223591,Unsafe,28414775,"Xp11.22 deletions encompassing CENPVL1, CENPVL2, MAGED1 and GSPT2 as a cause of syndromic X-linked intellectual disability.",2017,10.1371/journal.pone.0175962,https://pubmed.ncbi.nlm.nih.gov/28414775/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPVL2,ENSG00000283093,Unsafe,31555424,Further Clinical and Molecular Delineation of Xp11.22 Deletion Syndrome: A Case Report.,2019,10.5001/omj.2019.83,https://pubmed.ncbi.nlm.nih.gov/31555424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CENPVL2,ENSG00000283093,Unsafe,28414775,"Xp11.22 deletions encompassing CENPVL1, CENPVL2, MAGED1 and GSPT2 as a cause of syndromic X-linked intellectual disability.",2017,10.1371/journal.pone.0175962,https://pubmed.ncbi.nlm.nih.gov/28414775/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,42096526,A human CEP120 gene variant impairs meiotic spindle building causing aneuploidy†.,2026,10.1093/biolre/ioag094,https://pubmed.ncbi.nlm.nih.gov/42096526/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,40593860,Assessing the diagnostic impact of blood transcriptome profiling in a pediatric cohort previously assessed by genome sequencing.,2025,10.1038/s41525-025-00505-4,https://pubmed.ncbi.nlm.nih.gov/40593860/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,40558542,Exome Study of Single Nucleotide Variations in Patients with Syndromic and Non-Syndromic Autism Reveals Potential Candidate Genes for Diagnostics and Novel Single Nucleotide Variants.,2025,10.3390/cells14120915,https://pubmed.ncbi.nlm.nih.gov/40558542/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,40009365,Centriole structural integrity defects are a crucial feature of hydrolethalus syndrome.,2025,10.1083/jcb.202403022,https://pubmed.ncbi.nlm.nih.gov/40009365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,38177914,Cep120 is essential for kidney stromal progenitor cell growth and differentiation.,2024,10.1038/s44319-023-00019-z,https://pubmed.ncbi.nlm.nih.gov/38177914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,37982452,Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease.,2023,10.1242/dev.201976,https://pubmed.ncbi.nlm.nih.gov/37982452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,37915003,Machine learning algorithm predicts fibrosis-related blood diagnosis markers of intervertebral disc degeneration.,2023,10.1186/s12920-023-01705-6,https://pubmed.ncbi.nlm.nih.gov/37915003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,40282012,Genetic Architecture of Hock Joint Bumps in Pigs: Insights from ROH and GWAS Analyses.,2025,10.3390/ani15081178,https://pubmed.ncbi.nlm.nih.gov/40282012/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,36590171,Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4.,2023,10.1016/j.isci.2022.105745,https://pubmed.ncbi.nlm.nih.gov/36590171/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,33297941,Expression patterns of ciliopathy genes ARL3 and CEP120 reveal roles in multisystem development.,2020,10.1186/s12861-020-00231-3,https://pubmed.ncbi.nlm.nih.gov/33297941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,42124334,Maternal genetic variants associated with aneuploid conception: a narrative review.,2026,10.1093/humupd/dmag012,https://pubmed.ncbi.nlm.nih.gov/42124334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,34711653,CEP120-mediated KIAA0753 recruitment onto centrioles is required for timely neuronal differentiation and germinal zone exit in the developing cerebellum.,2021,10.1101/gad.348636.121,https://pubmed.ncbi.nlm.nih.gov/34711653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,35769319,The Mechanism of Heat Stress Resistance During Spermatogenesis in Turpan Black Sheep.,2022,10.3389/fvets.2022.846981,https://pubmed.ncbi.nlm.nih.gov/35769319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,33486889,"Update of genetic variants in CEP120 and CC2D2A-With an emphasis on genotype-phenotype correlations, tissue specific transcripts and exploring mutation specific exon skipping therapies.",2021,10.1002/mgg3.1603,https://pubmed.ncbi.nlm.nih.gov/33486889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,37547106,Clinical and genetic characteristics of 36 children with Joubert syndrome.,2023,10.3389/fped.2023.1102639,https://pubmed.ncbi.nlm.nih.gov/37547106/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,37895290,Genomic Scanning of Inbreeding Depression for Litter Size in Two Varieties of Iberian Pigs.,2023,10.3390/genes14101941,https://pubmed.ncbi.nlm.nih.gov/37895290/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,38494246,Role of gene interactions in the pathophysiology of skeletal dysplasias: A case report in Colombia.,2024,10.1016/j.jgeb.2023.100350,https://pubmed.ncbi.nlm.nih.gov/38494246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,39030352,Predicting Infertility: How Genetic Variants in Oocyte Spindle Genes Affect Egg Quality.,2024,10.1007/978-3-031-55163-5_1,https://pubmed.ncbi.nlm.nih.gov/39030352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,38585547,Reanalysis of Whole-Exome Sequencing Data of an Infant with Suspected Diagnosis of Jeune Syndrome Revealed a Likely Pathogenic Variant in GRK2: A Newly Associated Gene for Jeune Syndrome Phenotype.,2024,10.1159/000534031,https://pubmed.ncbi.nlm.nih.gov/38585547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,30988386,CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis.,2019,10.1038/s41598-019-42577-0,https://pubmed.ncbi.nlm.nih.gov/30988386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,32772081,Exome sequencing links CEP120 mutation to maternally derived aneuploid conception risk.,2020,10.1093/humrep/deaa148,https://pubmed.ncbi.nlm.nih.gov/32772081/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,35013207,Functional dissection of inherited non-coding variation influencing multiple myeloma risk.,2022,10.1038/s41467-021-27666-x,https://pubmed.ncbi.nlm.nih.gov/35013207/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,35443171,Centrosome-dependent microtubule modifications set the conditions for axon formation.,2022,10.1016/j.celrep.2022.110686,https://pubmed.ncbi.nlm.nih.gov/35443171/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,32227267,ANO9 Regulated Cell Cycle in Human Esophageal Squamous Cell Carcinoma.,2020,10.1245/s10434-020-08368-y,https://pubmed.ncbi.nlm.nih.gov/32227267/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP120,ENSG00000168944,Unsafe,20824097,Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.,2010,10.1371/journal.ppat.1001088,https://pubmed.ncbi.nlm.nih.gov/20824097/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,37249021,Modulation Effects of the CEP128 Gene on Radiotherapy-Related Brain Injury: A Longitudinal Structural Study Using Multi-Parametric Brain MR Images.,2024,10.1002/jmri.28824,https://pubmed.ncbi.nlm.nih.gov/37249021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,40168948,Integrative Molecular and Functional Analysis of Human Sperm Subpopulations to Identify New Biomarkers of Fertilization Potential.,2025,10.1016/j.arcmed.2025.103210,https://pubmed.ncbi.nlm.nih.gov/40168948/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,35296684,CEP128 is involved in spermatogenesis in humans and mice.,2022,10.1038/s41467-022-29109-7,https://pubmed.ncbi.nlm.nih.gov/35296684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,41533020,"Integrative gene target mapping, RNA sequencing, in silico molecular docking, ADMET profiling and molecular dynamics simulation study of marine derived molecules for type 1 diabetes mellitus.",2026,10.1007/s11030-025-11453-7,https://pubmed.ncbi.nlm.nih.gov/41533020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,37306467,"Editorial for ""Modulation Effects of the CEP128 Gene on Radiotherapy-Related Brain Injury: A Longitudinal Structural Study Using Multi-Parametric Brain MR Images"".",2024,10.1002/jmri.28825,https://pubmed.ncbi.nlm.nih.gov/37306467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,42027904,Runs of homozygosity reveal candidate genes for economic traits in Danish Large White pigs.,2026,10.5194/aab-69-25-2026,https://pubmed.ncbi.nlm.nih.gov/42027904/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,35391656,Downregulation of Circ-CEP128 Enhances the Paclitaxel Sensitivity of Cervical Cancer Through Regulating miR-432-5p/MCL1.,2022,10.1007/s10528-022-10201-y,https://pubmed.ncbi.nlm.nih.gov/35391656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,31599823,Knockdown of circular RNA CEP128 suppresses proliferation and improves cytotoxic efficacy of temozolomide in glioma cells by regulating miR-145-5p.,2019,10.1097/wnr.0000000000001326,https://pubmed.ncbi.nlm.nih.gov/31599823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,30299488,Genome-Wide Association Study of Susceptibility Loci for Radiation-Induced Brain Injury.,2019,10.1093/jnci/djy150,https://pubmed.ncbi.nlm.nih.gov/30299488/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,38316902,Dual-color live imaging unveils stepwise organization of multiple basal body arrays by cytoskeletons.,2024,10.1038/s44319-024-00066-0,https://pubmed.ncbi.nlm.nih.gov/38316902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,30393005,CEP128 is a crucial risk locus for autoimmune thyroid diseases.,2019,10.1016/j.mce.2018.10.017,https://pubmed.ncbi.nlm.nih.gov/30393005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,33116853,"Circ_0032821 Facilitates Gastric Cancer Cell Proliferation, Migration, Invasion and Glycolysis by Regulating MiR-1236-3p/HMGB1 Axis.",2020,10.2147/cmar.s270164,https://pubmed.ncbi.nlm.nih.gov/33116853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,30134837,Circular RNA CEP128 acts as a sponge of miR-145-5p in promoting the bladder cancer progression via regulating SOX11.,2018,10.1186/s10020-018-0039-0,https://pubmed.ncbi.nlm.nih.gov/30134837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,31960101,Associations between catechol-O-methyltransferase (COMT) genotypes at rs4818 and rs4680 and gene expression in human dorsolateral prefrontal cortex.,2020,10.1007/s00221-020-05730-0,https://pubmed.ncbi.nlm.nih.gov/31960101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,30939216,Circular RNA CEP128 promotes bladder cancer progression by regulating Mir-145-5p/Myd88 via MAPK signaling pathway.,2019,10.1002/ijc.32311,https://pubmed.ncbi.nlm.nih.gov/30939216/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,35205240,Investigation of the Genetic Architecture of Pigs Subjected to Breeding Intensification.,2022,10.3390/genes13020197,https://pubmed.ncbi.nlm.nih.gov/35205240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,35991636,Genome-wide association study of hyperthyroidism based on electronic medical record from Taiwan.,2022,10.3389/fmed.2022.830621,https://pubmed.ncbi.nlm.nih.gov/35991636/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,30606113,Genetic control of longissimus dorsi muscle gene expression variation and joint analysis with phenotypic quantitative trait loci in pigs.,2019,10.1186/s12864-018-5386-2,https://pubmed.ncbi.nlm.nih.gov/30606113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,27835906,Whole-exome and transcriptome sequencing of refractory diffuse large B-cell lymphoma.,2016,10.18632/oncotarget.13239,https://pubmed.ncbi.nlm.nih.gov/27835906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP128,ENSG00000100629,Unsafe,20966902,Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.,2011,10.1038/oby.2010.256,https://pubmed.ncbi.nlm.nih.gov/20966902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,42439625,Extra-Neurological Characterization of Seckel Syndrome-Model Mice Harboring &lt;i&gt;CEP152&lt;/i&gt; Variants.,2026,10.3390/cells15131148,https://pubmed.ncbi.nlm.nih.gov/42439625/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,42086905,Distinct pathophysiological mechanisms of CEP152 variants in microcephaly and brain abnormalities.,2026,10.1038/s44321-026-00427-3,https://pubmed.ncbi.nlm.nih.gov/42086905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,41616107,NuSAP Safeguards Centriole Integrity to Mediate CEP57-CEP152 Torus Recruitment for Proper Engagement.,2026,10.1002/advs.202515192,https://pubmed.ncbi.nlm.nih.gov/41616107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,41306914,Case Report: Compound heterozygous &lt;i&gt;CEP152&lt;/i&gt; c.3346-5T&gt;C variant and chr15 deletion causing recurrent MCPH-SCKS in a Chinese pregnant woman across two consecutive pregnancies.,2025,10.3389/fgene.2025.1646297,https://pubmed.ncbi.nlm.nih.gov/41306914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,40372713,Binding of CEP152 to PLK4 stimulates kinase activity to promote centriole assembly.,2025,10.1091/mbc.e24-12-0581,https://pubmed.ncbi.nlm.nih.gov/40372713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,40222413,PLK4 Homodimerization is Required for CEP152 Centrosome Localization and Spindle Organization.,2025,10.1016/j.jmb.2025.169152,https://pubmed.ncbi.nlm.nih.gov/40222413/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,42380124,Adaptable centriole biogenesis via the intrinsically disordered protein ALMS1.,2026,10.1038/s41467-026-74821-3,https://pubmed.ncbi.nlm.nih.gov/42380124/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,42685483,Transcriptomics reveals the gene expression dynamics during embryonic development of largemouth bass (Micropterus nigricans) at the endogenous nutrition stage.,2026,10.1016/j.cbd.2026.101994,https://pubmed.ncbi.nlm.nih.gov/42685483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,38229970,Novel Variants of CEP152 in a Case of Compound-Heterozygous Inheritance of Epilepsy.,2024,10.1055/s-0043-1777807,https://pubmed.ncbi.nlm.nih.gov/38229970/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,36685824,Two novel variants in CEP152 caused Seckel syndrome 5 in a Chinese family.,2022,10.3389/fgene.2022.1052915,https://pubmed.ncbi.nlm.nih.gov/36685824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,39780247,HnRNPM modulates alternative splicing in germ cells by recruiting PTBP1.,2025,10.1186/s12958-024-01340-5,https://pubmed.ncbi.nlm.nih.gov/39780247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,37707473,Centrosomal organization of Cep152 provides flexibility in Plk4 and procentriole positioning.,2023,10.1083/jcb.202301092,https://pubmed.ncbi.nlm.nih.gov/37707473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,35259752,"Expression Analyses of Cep152, a Responsible Gene Product for Autosomal Recessive Primary Microcephaly, during Mouse Brain Development.",2022,10.1159/000523922,https://pubmed.ncbi.nlm.nih.gov/35259752/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,39904373,Interactions of N- and C-terminal parts of Ana1 permitting centriole duplication but not elongation.,2025,10.1098/rsob.240325,https://pubmed.ncbi.nlm.nih.gov/39904373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,37433832,Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells.,2023,10.1038/s42003-023-05067-8,https://pubmed.ncbi.nlm.nih.gov/37433832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,34878135,The APC/C targets the Cep152-Cep63 complex at the centrosome to regulate mitotic spindle assembly.,2022,10.1242/jcs.259273,https://pubmed.ncbi.nlm.nih.gov/34878135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,37371259,"Microcephaly, Short Stature, Intellectual Disability, Speech Absence and Cataract Are Associated with Novel Bi-Allelic Missense Variant in RTTN Gene: A Seckel Syndrome Case Report.",2023,10.3390/children10061027,https://pubmed.ncbi.nlm.nih.gov/37371259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,37428363,Downregulation of Microcephaly-Causing Genes as a Mechanism for ZIKV Teratogenesis: A Meta-analysis of RNA-Seq Studies.,2023,10.1007/s12031-023-02126-x,https://pubmed.ncbi.nlm.nih.gov/37428363/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,32152252,Requirement of the Cep57-Cep63 Interaction for Proper Cep152 Recruitment and Centriole Duplication.,2020,10.1128/mcb.00535-19,https://pubmed.ncbi.nlm.nih.gov/32152252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,38857398,Cep57 regulates human centrosomes through multivalent interactions.,2024,10.1073/pnas.2305260121,https://pubmed.ncbi.nlm.nih.gov/38857398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,32636465,Tumor microenvironment characterization in head and neck cancer identifies prognostic and immunotherapeutically relevant gene signatures.,2020,10.1038/s41598-020-68074-3,https://pubmed.ncbi.nlm.nih.gov/32636465/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,35787744,Self-assembly of pericentriolar material in interphase cells lacking centrioles.,2022,10.7554/elife.77892,https://pubmed.ncbi.nlm.nih.gov/35787744/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,23936128,Cep63 and cep152 cooperate to ensure centriole duplication.,2013,10.1371/journal.pone.0069986,https://pubmed.ncbi.nlm.nih.gov/23936128/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,24268700,Spindle formation in the mouse embryo requires Plk4 in the absence of centrioles.,2013,10.1016/j.devcel.2013.09.029,https://pubmed.ncbi.nlm.nih.gov/24268700/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,21998596,CtIP Mutations Cause Seckel and Jawad Syndromes.,2011,10.1371/journal.pgen.1002310,https://pubmed.ncbi.nlm.nih.gov/21998596/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,22219177,A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.,2012,10.1093/carcin/bgr316,https://pubmed.ncbi.nlm.nih.gov/22219177/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP152,ENSG00000103995,Unsafe,21668957,"Autosomal Recessive Primary Microcephaly (MCPH): clinical manifestations, genetic heterogeneity and mutation continuum.",2011,10.1186/1750-1172-6-39,https://pubmed.ncbi.nlm.nih.gov/21668957/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,41905261,Centromere protein CEP170 is dispensable for mouse spermatogenesis and male fertility.,2026,10.1016/j.theriogenology.2026.117912,https://pubmed.ncbi.nlm.nih.gov/41905261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,41888776,CEP170 as a novel molecular link between centrosomal function and cerebral cortical development.,2026,10.1186/s12929-026-01236-z,https://pubmed.ncbi.nlm.nih.gov/41888776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,42324259,Sensing centrosome amplification: the interface between centriole duplication and autophagy.,2026,10.1038/s41467-026-74702-9,https://pubmed.ncbi.nlm.nih.gov/42324259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,39708485,METTL3-mediated CEP170 m6A modifications in spindle orientation and esophageal cancer cell proliferation.,2025,10.1016/j.intimp.2024.113780,https://pubmed.ncbi.nlm.nih.gov/39708485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,41661662,Screen Time and Chronic Pain Health: Mendelian Randomization Study.,2026,10.2196/78233,https://pubmed.ncbi.nlm.nih.gov/41661662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,42116291,Potential therapeutic targets for multisite chronic pain: A proteome-wide Mendelian randomization study.,2026,10.1097/md.0000000000048579,https://pubmed.ncbi.nlm.nih.gov/42116291/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,41882697,SIRT1 haploinsufficiency recapitulates age-associated subfertility through sperm α-tubulin hyperacetylation.,2026,10.1186/s13062-025-00710-2,https://pubmed.ncbi.nlm.nih.gov/41882697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,42343301,A microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces cell cycle arrest and senescence.,2026,10.1186/s12964-026-03019-3,https://pubmed.ncbi.nlm.nih.gov/42343301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,41358547,Meta-analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape.,2026,10.1111/epi.70035,https://pubmed.ncbi.nlm.nih.gov/41358547/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,38533689,Roles for CEP170 in cilia function and dynein-2 assembly.,2024,10.1242/jcs.261816,https://pubmed.ncbi.nlm.nih.gov/38533689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,37903275,CAMSAP1 role in orchestrating structure and dynamics of manchette microtubule minus-ends impacts male fertility during spermiogenesis.,2023,10.1073/pnas.2313787120,https://pubmed.ncbi.nlm.nih.gov/37903275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,41057298,"The dynamic role of TRIM8, a novel ciliary protein, during various stages of mitosis.",2025,10.1038/s41419-025-07973-7,https://pubmed.ncbi.nlm.nih.gov/41057298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,37664992,Centriolar subdistal appendages promote double-strand break repair through homologous recombination.,2023,10.15252/embr.202256724,https://pubmed.ncbi.nlm.nih.gov/37664992/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,37873933,"Analysis, validation, and discussion of key genes in placenta of patients with gestational diabetes mellitus.",2023,10.1177/15353702231199077,https://pubmed.ncbi.nlm.nih.gov/37873933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,40154916,Cryo-EM of AKAP350/AKAP9 Reveals Fibrillar Clusters and an Association With DNA.,2025,10.1016/j.jmb.2025.169102,https://pubmed.ncbi.nlm.nih.gov/40154916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,41225720,"Extrauterine RAD51B -Rearranged Soft Tissue Tumors : A Clinicopathologic and Molecular Genetic Study of 10 Cases With Heterogeneous Morphology, Novel Fusions, and a Distinct Methylation Profile.",2026,10.1097/pas.0000000000002485,https://pubmed.ncbi.nlm.nih.gov/41225720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,39168978,A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease.,2024,10.1038/s41467-024-51354-1,https://pubmed.ncbi.nlm.nih.gov/39168978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,40879105,The Kinesin Motor Kif9 Disrupts Primary Cilia Length by Mispositioning Centriolar Satellites.,2025,10.1096/fj.202501115r,https://pubmed.ncbi.nlm.nih.gov/40879105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,39201744,Genomic Insights into Idiopathic Granulomatous Mastitis through Whole-Exome Sequencing: A Case Report of Eight Patients.,2024,10.3390/ijms25169058,https://pubmed.ncbi.nlm.nih.gov/39201744/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,40281631,Plasma cell-free DNA methylation profile before afatinib treatment is associated with progression-free and overall survival of patients with epidermal growth factor receptor gene mutation-positive non-small cell lung cancer.,2025,10.1186/s13148-025-01870-8,https://pubmed.ncbi.nlm.nih.gov/40281631/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,35967285,NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma.,2022,10.1016/j.apsb.2022.01.015,https://pubmed.ncbi.nlm.nih.gov/35967285/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,38898508,Identification of novel therapeutic targets for chronic kidney disease and kidney function by integrating multi-omics proteome with transcriptome.,2024,10.1186/s13073-024-01356-x,https://pubmed.ncbi.nlm.nih.gov/38898508/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,34853430,Bronchopulmonary dysplasia and wnt pathway-associated single nucleotide polymorphisms.,2022,10.1038/s41390-021-01851-6,https://pubmed.ncbi.nlm.nih.gov/34853430/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,34620840,BUB1B and circBUB1B_544aa aggravate multiple myeloma malignancy through evoking chromosomal instability.,2021,10.1038/s41392-021-00746-6,https://pubmed.ncbi.nlm.nih.gov/34620840/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,34090465,CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma.,2021,10.1186/s12943-021-01380-0,https://pubmed.ncbi.nlm.nih.gov/34090465/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,25435094,Gene expression microarray analysis of the sciatic nerve of mice with diabetic neuropathy.,2015,10.3892/ijmm.2014.2011,https://pubmed.ncbi.nlm.nih.gov/25435094/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP170,ENSG00000143702,Unsafe,29330283,Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma.,2018,10.1158/1541-7786.mcr-17-0197,https://pubmed.ncbi.nlm.nih.gov/29330283/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP19,ENSG00000174007,Unsafe,41218617,Prognostic Significance of Actinin-4 Protein Expression and Gene Amplification in Endometrial Carcinoma.,2025,10.1111/jog.70132,https://pubmed.ncbi.nlm.nih.gov/41218617/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP19,ENSG00000174007,Unsafe,39712340,Whole exome sequencing revealed new variants and haplotypes associated with monogenic obesity.,2025,10.1007/s40200-024-01507-2,https://pubmed.ncbi.nlm.nih.gov/39712340/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP19,ENSG00000174007,Unsafe,38585545,Severe Early-Onset Obesity and Diabetic Ketoacidosis due to a Novel Homozygous c.169C>T p.Arg57* Variant in CEP19 Gene.,2024,10.1159/000535253,https://pubmed.ncbi.nlm.nih.gov/38585545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP19,ENSG00000174007,Unsafe,37606072,The IFT81-IFT74 complex acts as an unconventional RabL2 GTPase-activating protein during intraflagellar transport.,2023,10.15252/embj.2022111807,https://pubmed.ncbi.nlm.nih.gov/37606072/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP19,ENSG00000174007,Unsafe,36074075,CEP19-RABL2-IFT-B axis controls BBSome-mediated ciliary GPCR export.,2022,10.1091/mbc.e22-05-0161,https://pubmed.ncbi.nlm.nih.gov/36074075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP19,ENSG00000174007,Unsafe,35194111,Weighted correlation network analysis revealed novel long non-coding RNAs for colorectal cancer.,2022,10.1038/s41598-022-06934-w,https://pubmed.ncbi.nlm.nih.gov/35194111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP19,ENSG00000174007,Unsafe,37540954,Comparison of symmetrical and asymmetrical cleavage 2-cell embryos of porcine by Smart-seq2.,2023,10.1016/j.theriogenology.2023.07.029,https://pubmed.ncbi.nlm.nih.gov/37540954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP19,ENSG00000174007,Unsafe,28428259,RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly.,2017,10.1091/mbc.e17-01-0017,https://pubmed.ncbi.nlm.nih.gov/28428259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP19,ENSG00000174007,Unsafe,28659385,CEP19 cooperates with FOP and CEP350 to drive early steps in the ciliogenesis programme.,2017,10.1098/rsob.170114,https://pubmed.ncbi.nlm.nih.gov/28659385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP19,ENSG00000174007,Unsafe,34646484,Comparative transcriptome provides insights into the selection adaptation between wild and farmed foxes.,2021,10.1002/ece3.8071,https://pubmed.ncbi.nlm.nih.gov/34646484/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP19,ENSG00000174007,Unsafe,36474803,Genetic and epigenetic interplay allows rapid transgenerational adaptation to metal pollution in zebrafish.,2022,10.1093/eep/dvac022,https://pubmed.ncbi.nlm.nih.gov/36474803/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP19,ENSG00000174007,Unsafe,32681070,"Analysis of the ""centrosome-ome"" identifies MCPH1 deletion as a cause of centrosome amplification in human cancer.",2020,10.1038/s41598-020-68629-4,https://pubmed.ncbi.nlm.nih.gov/32681070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP19,ENSG00000174007,Unsafe,28625565,The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.,2017,10.1016/j.devcel.2017.05.016,https://pubmed.ncbi.nlm.nih.gov/28625565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP19,ENSG00000174007,Unsafe,24268657,Morbid obesity resulting from inactivation of the ciliary protein CEP19 in humans and mice.,2013,10.1016/j.ajhg.2013.10.025,https://pubmed.ncbi.nlm.nih.gov/24268657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP19,ENSG00000174007,Unsafe,30258116,A distal centriolar protein network controls organelle maturation and asymmetry.,2018,10.1038/s41467-018-06286-y,https://pubmed.ncbi.nlm.nih.gov/30258116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP57L1,ENSG00000183137,Unsafe,41443421,AGEs promote the metastasis of colorectal cancer cells via centrosome amplification by KLF5-CEP57L1 axis.,2026,10.1016/j.jbc.2025.111098,https://pubmed.ncbi.nlm.nih.gov/41443421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP57L1,ENSG00000183137,Unsafe,40593068,Predicting cisplatin response in cholangiocarcinoma patients using chromosome pattern and related gene expression.,2025,10.1038/s41598-025-06851-8,https://pubmed.ncbi.nlm.nih.gov/40593068/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP57L1,ENSG00000183137,Unsafe,33492359,Cep57 and Cep57L1 maintain centriole engagement in interphase to ensure centriole duplication cycle.,2021,10.1083/jcb.202005153,https://pubmed.ncbi.nlm.nih.gov/33492359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP57L1,ENSG00000183137,Unsafe,26561035,Copy number variation in CEP57L1 predisposes to congenital absence of bilateral ACL and PCL ligaments.,2015,10.1186/s40246-015-0053-z,https://pubmed.ncbi.nlm.nih.gov/26561035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP57L1,ENSG00000183137,Unsafe,22508265,"Cep57, a NEDD1-binding pericentriolar material component, is essential for spindle pole integrity.",2012,10.1038/cr.2012.61,https://pubmed.ncbi.nlm.nih.gov/22508265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,39747485,Cep78 knockout causes sterility and oligoasthenoteratozoospermia in male mice.,2025,10.1038/s41598-024-84006-x,https://pubmed.ncbi.nlm.nih.gov/39747485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,42265085,Nek1 defines a branch of centriolar microtubule length control parallel to CP110-Cep97.,2026,10.1038/s41467-026-73560-9,https://pubmed.ncbi.nlm.nih.gov/42265085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,36756949,Absence of CEP78 causes photoreceptor and sperm flagella impairments in mice and a human individual.,2023,10.7554/elife.76157,https://pubmed.ncbi.nlm.nih.gov/36756949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,36206347,Loss-of-function mutations in CEP78 cause male infertility in humans and mice.,2022,10.1126/sciadv.abn0968,https://pubmed.ncbi.nlm.nih.gov/36206347/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,38780195,Exploring the diverse clinical and variant spectrum of CEP78-associated syndrome: Novel pathogenic variants identified in a case series.,2024,10.1002/ajmg.a.63720,https://pubmed.ncbi.nlm.nih.gov/38780195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,38540441,Genome-Wide Association Analysis of Semen Characteristics in Piétrain Boars.,2024,10.3390/genes15030382,https://pubmed.ncbi.nlm.nih.gov/38540441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,41293945,Identifying Key Epigenetic Modification-Related Genes for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma and Cellular Validation.,2026,10.2174/0115665232432474251103064112,https://pubmed.ncbi.nlm.nih.gov/41293945/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,33968938,Long-Read Sequencing to Unravel Complex Structural Variants of CEP78 Leading to Cone-Rod Dystrophy and Hearing Loss.,2021,10.3389/fcell.2021.664317,https://pubmed.ncbi.nlm.nih.gov/33968938/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,34259627,CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels.,2021,10.7554/elife.63731,https://pubmed.ncbi.nlm.nih.gov/34259627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,35543806,Patient with multiple morphological abnormalities of sperm flagella caused by a novel ARMC2 mutation has a favorable pregnancy outcome from intracytoplasmic sperm injection.,2022,10.1007/s10815-022-02516-x,https://pubmed.ncbi.nlm.nih.gov/35543806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,33119552,Centrosome Protein 78 Is Overexpressed in Muscle-Invasive Bladder Cancer and Is Associated with Tumor Molecular Subtypes and Mutation Signatures.,2020,10.12659/msm.925197,https://pubmed.ncbi.nlm.nih.gov/33119552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,35240912,"A novel frameshift variant in CEP78 associated with nonsyndromic retinitis pigmentosa, and a review of CEP78-related phenotypes.",2022,10.1080/13816810.2022.2045511,https://pubmed.ncbi.nlm.nih.gov/35240912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,37023829,A deep transcriptome meta-analysis reveals sex differences in multiple sclerosis.,2023,10.1016/j.nbd.2023.106113,https://pubmed.ncbi.nlm.nih.gov/37023829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,36315013,"The central scaffold protein CEP350 coordinates centriole length, stability, and maturation.",2022,10.1083/jcb.202203081,https://pubmed.ncbi.nlm.nih.gov/36315013/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,31999394,"Functional characterization of the first missense variant in CEP78, a founder allele associated with cone-rod dystrophy, hearing loss, and reduced male fertility.",2020,10.1002/humu.23993,https://pubmed.ncbi.nlm.nih.gov/31999394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,30884127,Significance of CEP78 and WDR62 gene expressions in differentiated thyroid carcinoma: Possible predictors of lateral lymph node metastasis.,2019,10.1111/ajco.13143,https://pubmed.ncbi.nlm.nih.gov/30884127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,34223797,Expanding the clinical phenotype in patients with disease causing variants associated with atypical Usher syndrome.,2021,10.1080/13816810.2021.1946704,https://pubmed.ncbi.nlm.nih.gov/34223797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,27588451,Mutations in CEP78 Cause Cone-Rod Dystrophy and Hearing Loss Associated with Primary-Cilia Defects.,2016,10.1016/j.ajhg.2016.07.009,https://pubmed.ncbi.nlm.nih.gov/27588451/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,27357513,Low expression of centrosomal protein 78 (CEP78) is associated with poor prognosis of colorectal cancer patients.,2016,10.1186/s40880-016-0121-3,https://pubmed.ncbi.nlm.nih.gov/27357513/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,27588452,"Bi-allelic Truncating Mutations in CEP78, Encoding Centrosomal Protein 78, Cause Cone-Rod Degeneration with Sensorineural Hearing Loss.",2016,10.1016/j.ajhg.2016.07.010,https://pubmed.ncbi.nlm.nih.gov/27588452/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CEP78,ENSG00000148019,Unsafe,17332294,Standard treatments induce antigen-specific immune responses in prostate cancer.,2007,10.1158/1078-0432.ccr-06-1772,https://pubmed.ncbi.nlm.nih.gov/17332294/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,42087192,TRAM-LAG1-CLN8 domain-containing protein TMEM56 regulates cell migration by changing intracellular ceramide levels.,2026,10.1186/s12915-026-02614-7,https://pubmed.ncbi.nlm.nih.gov/42087192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,41750370,"Association of Clinical Severity in Autism Spectrum Disorder with Biomolecules Involved in Lipid Metabolism, Inflammation and miRNAs.",2026,10.3390/biom16020303,https://pubmed.ncbi.nlm.nih.gov/41750370/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,40892691,KLF9 Inhibits Brain Metastasis of Non-Small Cell Lung Cancer by Regulating Ceramide Synthase 1 Synthesis.,2025,10.1096/fj.202501354r,https://pubmed.ncbi.nlm.nih.gov/40892691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,42030684,miR-1180-3p as a biomarker of obstructive sleep apnea hypopnea syndrome and its role in chronic intermittent hypoxia-induced vascular injury.,2026,10.1016/j.clinsp.2026.100944,https://pubmed.ncbi.nlm.nih.gov/42030684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,42495817,Localization of Ceramide Synthase 5 in Mouse Retina.,2026,10.1002/cne.70192,https://pubmed.ncbi.nlm.nih.gov/42495817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,40537488,Exercise improves depressive-like behavior in adolescent mice by regulating sphingosine and ceramide metabolism through microglial CerS1.,2025,10.1038/s42003-025-08347-7,https://pubmed.ncbi.nlm.nih.gov/40537488/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,41235932,Prevotella copri facilitates wound healing in mice through the sphingosine-CerS1-ceramide metabolic pathway.,2026,10.1128/spectrum.01587-25,https://pubmed.ncbi.nlm.nih.gov/41235932/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,42365880,"The 24,25(OH)&lt;sub&gt;2&lt;/sub&gt;D&lt;sub&gt;3&lt;/sub&gt;-TLCD3B signaling complex and reproductive function in mice and men.",2026,10.1016/j.jsbmb.2026.107060,https://pubmed.ncbi.nlm.nih.gov/42365880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,41748537,"Inhibiting HSP27 activates the XBP1s/CerS1 interplay, which triggers DRP1-driven mitophagy, thereby protecting against cell death and promoting the KSHV lytic cycle in primary effusion lymphoma cells.",2026,10.1038/s41420-026-02979-2,https://pubmed.ncbi.nlm.nih.gov/41748537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,42093330,Uncoupling of nutrient sensing and cell size control by specific defects in ceramide structure.,2026,10.1242/bio.062633,https://pubmed.ncbi.nlm.nih.gov/42093330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,40540357,Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression.,2025,10.1158/0008-5472.can-24-4042,https://pubmed.ncbi.nlm.nih.gov/40540357/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,41372954,Heterogeneity of common carotid artery and abdominal aorta: an angle of sphingolipid metabolism in vascular smooth muscle cells.,2025,10.1186/s12938-025-01473-7,https://pubmed.ncbi.nlm.nih.gov/41372954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,38506902,Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction.,2024,10.7554/elife.90522,https://pubmed.ncbi.nlm.nih.gov/38506902/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,41608628,Combining sorafenib with spermine and sphingosine synergistically enhances anticancer efficacy by modulating metabolic pathways and gut microbiome in hepatocellular carcinoma.,2026,10.7150/ijbs.118753,https://pubmed.ncbi.nlm.nih.gov/41608628/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,41286244,Gender differences in attentional blink in children with attention deficit hyperactivity disorder.,2025,10.1038/s41598-025-28910-w,https://pubmed.ncbi.nlm.nih.gov/41286244/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,41257868,"Cannabidiol in pancreatic ductal adenocarcinoma: preclinical evidence, molecular mechanisms, and translational challenges.",2025,10.1186/s12935-025-04062-9,https://pubmed.ncbi.nlm.nih.gov/41257868/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,38720356,Cannabidiol's cytotoxicity in pancreatic cancer is induced via an upregulation of ceramide synthase 1 and ER stress.,2024,10.1186/s42238-024-00227-x,https://pubmed.ncbi.nlm.nih.gov/38720356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,37046655,Ceramide Synthase 1 Inhibits Brain Metastasis of Non-Small Cell Lung Cancer by Interacting with USP14 and Downregulating the PI3K/AKT/mTOR Signaling Pathway.,2023,10.3390/cancers15071994,https://pubmed.ncbi.nlm.nih.gov/37046655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,41856194,Sirtuin 1 mediated ceramide metabolism regulates intestinal mechanical barrier function in turbot (Scophthalmus maximus L.).,2026,10.1016/j.ijbiomac.2026.151473,https://pubmed.ncbi.nlm.nih.gov/41856194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,38164625,Expression of Ceramide Synthases in Mice and Their Roles in Regulating Acyl-Chain Sphingolipids: A Framework for Baseline Levels and Future Implications in Aging and Disease.,2024,10.1124/molpharm.123.000788,https://pubmed.ncbi.nlm.nih.gov/38164625/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,42155267,Integrated lipidomics and transcriptomics reveal different lipid profiles and metabolic pathways in cultured fats from porcine subcutaneous adipocytes and fibro-adipogenic progenitors.,2026,10.1016/j.foodchem.2026.149682,https://pubmed.ncbi.nlm.nih.gov/42155267/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,41260034,Does personalization in exposure assessment change ambient air pollution exposure-response relationships? A panel study.,2025,10.1016/j.ecoenv.2025.119422,https://pubmed.ncbi.nlm.nih.gov/41260034/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,40537710,Particulate matter concentration is associated with increased utilization of the emergency department: a single-centre time-series analysis.,2026,10.1007/s11739-025-04013-2,https://pubmed.ncbi.nlm.nih.gov/40537710/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,39343173,CERS1 is a biomarker of Staphylococcus aureus abundance and atopic dermatitis severity.,2025,10.1016/j.jaci.2024.09.017,https://pubmed.ncbi.nlm.nih.gov/39343173/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,39834330,Bayesian-optimized deep learning for identifying essential genes of mitophagy and fostering therapies to combat drug resistance in human cancers.,2025,10.1111/jcmm.18254,https://pubmed.ncbi.nlm.nih.gov/39834330/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,41049114,Seasonal Variations of Vogt-Koyanagi-Harada Disease in Japan: A Study on Long-Term Trends and the Influence of Coronavirus Disease 2019 (COVID-19).,2026,10.1016/j.xops.2025.100902,https://pubmed.ncbi.nlm.nih.gov/41049114/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,42698726,"Daily changes in fine particulate matter are associated with acute myocardial infarction hospitalizations: an individual-level time-stratified case-crossover study in Zhongshan, China.",2026,10.3389/fpubh.2026.1911027,https://pubmed.ncbi.nlm.nih.gov/42698726/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,37614280,Role of Ceramide Synthase 1 in Oral Leukoplakia and Oral Squamous Cell Carcinoma: A Potential Linchpin for Tumorigenesis.,2023,10.7759/cureus.42308,https://pubmed.ncbi.nlm.nih.gov/37614280/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,41446525,"Association between air pollution and emergency department visits for unintentional injuries in four cities of Shandong Province, China.",2025,10.3389/fpubh.2025.1710542,https://pubmed.ncbi.nlm.nih.gov/41446525/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,40830449,"Impact of black carbon exposure on length of hospital stay in asthma patients: a retrospective cohort study in yulin, China.",2025,10.1186/s12889-025-24143-8,https://pubmed.ncbi.nlm.nih.gov/40830449/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,38328780,p17/C18-ceramide-mediated mitophagy is an endogenous neuroprotective response in preclinical and clinical brain injury.,2024,10.1093/pnasnexus/pgae018,https://pubmed.ncbi.nlm.nih.gov/38328780/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,39335193,Immunological Tumor Microenvironment of Solitary Fibrous Tumors-Associating Immune Infiltrate with Variables of Prognostic Significance.,2024,10.3390/cancers16183222,https://pubmed.ncbi.nlm.nih.gov/39335193/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,42112515,Modifying effect of statin use on the association between nitrogen dioxide exposure and ischemic heart disease in patients with hypertension.,2026,10.5646/ch.2026.32.e22,https://pubmed.ncbi.nlm.nih.gov/42112515/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS1,ENSG00000223802,Unsafe,40963858,Multi-disease transcriptomic analysis of sex hormone genes reveals a novel prognostic model for thyroid cancer with breast cancer correlations.,2025,10.3389/fonc.2025.1641195,https://pubmed.ncbi.nlm.nih.gov/40963858/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,42883979,Ceramide Metabolic Pathways and Their Regulation in Adolescent Acne Vulgaris.,2026,10.3390/ijms27198737,https://pubmed.ncbi.nlm.nih.gov/42883979/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,42511026,Optimization of a Canine-Specific Ceramide Complex and Evaluation of Its Effects on In Vitro and In Vivo Canine Skin.,2026,10.3390/ani16142148,https://pubmed.ncbi.nlm.nih.gov/42511026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,40609532,Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression.,2025,10.1016/j.cmet.2025.06.002,https://pubmed.ncbi.nlm.nih.gov/40609532/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,42295031,Potential of 3D Skin Models and N/TERT-2G Cell Line in Genetic Research on Autosomal Recessive Nonsyndromic Epidermal Differentiation Disorders.,2026,10.1111/exd.70298,https://pubmed.ncbi.nlm.nih.gov/42295031/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,41856194,Sirtuin 1 mediated ceramide metabolism regulates intestinal mechanical barrier function in turbot (Scophthalmus maximus L.).,2026,10.1016/j.ijbiomac.2026.151473,https://pubmed.ncbi.nlm.nih.gov/41856194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,42643438,Extracellular vesicles from &lt;i&gt;Lactobacillus plantarum&lt;/i&gt; alleviate DNFB-induced atopic dermatitis in mice by reconstructing the skin barrier and inhibiting inflammation.,2026,10.3389/fimmu.2026.1873193,https://pubmed.ncbi.nlm.nih.gov/42643438/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,40950347,GBA3 as a regulator of sphingolipid metabolism in the progression of hepatocellular carcinoma.,2025,10.21037/jgo-2025-567,https://pubmed.ncbi.nlm.nih.gov/40950347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,40595762,"Polysaccharide from Prinsepia utilis Royle maintains the skin barrier by mediating differentiation, lipid metabolism and tight junction of keratinocyte.",2025,10.1038/s41598-025-01960-w,https://pubmed.ncbi.nlm.nih.gov/40595762/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,41024457,Epigenetic remodeling of sheep oocytes and embryos induced by maternal methionine supplementation.,2025,10.1080/15592294.2025.2567459,https://pubmed.ncbi.nlm.nih.gov/41024457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,41966446,Tape strips capture immune and epidermal hyperplasia markers in the major orphan ichthyoses.,2026,10.1016/j.jid.2026.03.033,https://pubmed.ncbi.nlm.nih.gov/41966446/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,39147981,DNA Methylation Patterns Associated with Tinnitus in Young Adults-A Pilot Study.,2024,10.1007/s10162-024-00961-2,https://pubmed.ncbi.nlm.nih.gov/39147981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,42093330,Uncoupling of nutrient sensing and cell size control by specific defects in ceramide structure.,2026,10.1242/bio.062633,https://pubmed.ncbi.nlm.nih.gov/42093330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,36831084,Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis.,2023,10.3390/biomedicines11020548,https://pubmed.ncbi.nlm.nih.gov/36831084/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,40143670,Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations.,2025,10.1080/15592294.2025.2477850,https://pubmed.ncbi.nlm.nih.gov/40143670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,42044130,Dysregulation of Fatty Acid and Sphingolipid Metabolism Is Involved in Abnormal Nasal Epithelial Differentiation.,2026,10.1159/000552208,https://pubmed.ncbi.nlm.nih.gov/42044130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,33844153,Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice.,2021,10.1007/s13311-021-01043-4,https://pubmed.ncbi.nlm.nih.gov/33844153/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,40084708,Effects of natural killer cell‑conditioned medium on UVB‑induced photoaging in human keratinocytes and a human reconstructed skin model.,2025,10.3892/mmr.2025.13488,https://pubmed.ncbi.nlm.nih.gov/40084708/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,37298446,Expression of Ceramide-Metabolizing Enzymes in the Heart Adipose Tissue of Cardiovascular Disease Patients.,2023,10.3390/ijms24119494,https://pubmed.ncbi.nlm.nih.gov/37298446/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,36841478,Differentiation-linked changes in the biosynthesis and turnover of sphingomyelins in rat male germ cells: Genes involved and effects of testosterone.,2023,10.1016/j.jbc.2023.103058,https://pubmed.ncbi.nlm.nih.gov/36841478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,36068200,"S1PR1 induces metabolic reprogramming of ceramide in vascular endothelial cells, affecting hepatocellular carcinoma angiogenesis and progression.",2022,10.1038/s41419-022-05210-z,https://pubmed.ncbi.nlm.nih.gov/36068200/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,40689642,Host sphingolipids support &lt;i&gt;Plasmodium berghei&lt;/i&gt; liver stage development.,2025,10.1128/mbio.01675-25,https://pubmed.ncbi.nlm.nih.gov/40689642/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,39408700,Hair Growth-Promoting Effect of Hydrangea serrata (Thunb.) Ser. Extract and Its Active Component Hydrangenol: In Vitro and In Vivo Study.,2024,10.3390/ijms251910370,https://pubmed.ncbi.nlm.nih.gov/39408700/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,34067529,Generation of Stilbene Glycoside with Promising Cell Rejuvenation Activity through Biotransformation by the Entomopathogenic Fungus Beauveria bassiana.,2021,10.3390/biomedicines9050555,https://pubmed.ncbi.nlm.nih.gov/34067529/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,32316273,Gentiana lutea Extract Modulates Ceramide Synthesis in Primary and Psoriasis-Like Keratinocytes.,2020,10.3390/molecules25081832,https://pubmed.ncbi.nlm.nih.gov/32316273/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,30838224,IFN-γ Reduces Epidermal Barrier Function by Affecting Fatty Acid Composition of Ceramide in a Mouse Atopic Dermatitis Model.,2019,10.1155/2019/3030268,https://pubmed.ncbi.nlm.nih.gov/30838224/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,19609004,Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism.,2009,10.1158/1541-7786.mcr-08-0361,https://pubmed.ncbi.nlm.nih.gov/19609004/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CERS3,ENSG00000154227,Unsafe,23754960,Mutations in CERS3 cause autosomal recessive congenital ichthyosis in humans.,2013,10.1371/journal.pgen.1003536,https://pubmed.ncbi.nlm.nih.gov/23754960/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP100,ENSG00000163885,Unsafe,42764307,CFAP100 forms phase-separated condensates required for ciliary transition zone assembly.,2026,10.1038/s41467-026-76995-2,https://pubmed.ncbi.nlm.nih.gov/42764307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP100,ENSG00000163885,Unsafe,40593606,CFAP100 couples microtubule glutamylation to spindle pole integrity in keratinocytes to promote epidermal development.,2025,10.1038/s41467-025-60677-6,https://pubmed.ncbi.nlm.nih.gov/40593606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP100,ENSG00000163885,Unsafe,41376450,Genome-Wide Association Study (GWAS) for Linear Body Measurements of Sussex Cattle (Bos taurus) at Weaning and Yearling Age in South Africa.,2026,10.1002/vms3.70717,https://pubmed.ncbi.nlm.nih.gov/41376450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP100,ENSG00000163885,Unsafe,37394828,Seminal Plasma ExLncRNA Pairs: Updating Perspectives in the Search for Testicular Spermatozoa Retrieval Biomarkers in Nonobstructive Azoospermia Patients with mTESE by WGCNA.,2023,10.22037/uj.v20i.7323,https://pubmed.ncbi.nlm.nih.gov/37394828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP100,ENSG00000163885,Unsafe,37192300,The Bacillus cereus toxin alveolysin disrupts the intestinal epithelial barrier by inducing microtubule disorganization through CFAP100.,2023,10.1126/scisignal.ade8111,https://pubmed.ncbi.nlm.nih.gov/37192300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP100,ENSG00000163885,Unsafe,26200272,Epigenetic Repression of CCDC37 and MAP1B Links Chronic Obstructive Pulmonary Disease to Lung Cancer.,2015,10.1097/jto.0000000000000592,https://pubmed.ncbi.nlm.nih.gov/26200272/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP100,ENSG00000163885,Unsafe,32914196,A panel of extracellular vesicle long noncoding RNAs in seminal plasma for predicting testicular spermatozoa in nonobstructive azoospermia patients.,2020,10.1093/humrep/deaa184,https://pubmed.ncbi.nlm.nih.gov/32914196/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP100,ENSG00000163885,Unsafe,31097021,Multicellular gene network analysis identifies a macrophage-related gene signature predictive of therapeutic response and prognosis of gliomas.,2019,10.1186/s12967-019-1908-1,https://pubmed.ncbi.nlm.nih.gov/31097021/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP100,ENSG00000163885,Unsafe,30598658,The plasma peptides of ovarian cancer.,2018,10.1186/s12014-018-9215-z,https://pubmed.ncbi.nlm.nih.gov/30598658/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP100,ENSG00000163885,Unsafe,22011669,Genome-wide analysis of DNA methylation and the gene expression change in lung cancer.,2012,10.1097/jto.0b013e3182307f62,https://pubmed.ncbi.nlm.nih.gov/22011669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP107,ENSG00000157330,Unsafe,31921204,Exome Sequencing Identifies Susceptibility Loci for Sarcoidosis Prognosis.,2019,10.3389/fimmu.2019.02964,https://pubmed.ncbi.nlm.nih.gov/31921204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP107,ENSG00000157330,Unsafe,36191189,SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.,2022,10.1073/pnas.2207605119,https://pubmed.ncbi.nlm.nih.gov/36191189/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP126,ENSG00000188931,Unsafe,40992249,Generation of a Flattop-T2A-H2B-Venus x C-peptide-mCherry double reporter human iPSC line to monitor WNT/Planar cell polarity pathway activity.,2025,10.1016/j.scr.2025.103838,https://pubmed.ncbi.nlm.nih.gov/40992249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP126,ENSG00000188931,Unsafe,40495298,Perioperative fluid therapy impairs lymphatic pump function in male rats.,2025,10.14814/phy2.70389,https://pubmed.ncbi.nlm.nih.gov/40495298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP126,ENSG00000188931,Unsafe,38491953,Analysis of clinical characteristics and histopathological transcription in 40 patients afflicted by epilepsy stemming from focal cortical dysplasia.,2024,10.1002/epi4.12928,https://pubmed.ncbi.nlm.nih.gov/38491953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP126,ENSG00000188931,Unsafe,38550390,Transcriptomic Analysis of Gene Expression and Effect of Electromagnetic Field in Brain Tissue after Traumatic Brain Injury.,2024,10.26502/jbb.2642-91280131,https://pubmed.ncbi.nlm.nih.gov/38550390/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP126,ENSG00000188931,Unsafe,38218829,Piloting a one-day parent-only intervention in the treatment of youth with anxiety disorders: child and family-level outcomes.,2024,10.1186/s13034-023-00702-y,https://pubmed.ncbi.nlm.nih.gov/38218829/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP126,ENSG00000188931,Unsafe,27398620,Identification of proliferative and mature β-cells in the islets of Langerhans.,2016,10.1038/nature18624,https://pubmed.ncbi.nlm.nih.gov/27398620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP126,ENSG00000188931,Unsafe,25296022,Flattop regulates basal body docking and positioning in mono- and multiciliated cells.,2014,10.7554/elife.03842,https://pubmed.ncbi.nlm.nih.gov/25296022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP126,ENSG00000188931,Unsafe,22153975,Fltp(T2AiCre): a new knock-in mouse line for conditional gene targeting in distinct mono- and multiciliated tissues.,2012,10.1016/j.diff.2011.11.003,https://pubmed.ncbi.nlm.nih.gov/22153975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP126,ENSG00000188931,Unsafe,28099206,Is a β cell a β cell?,2017,10.1097/med.0000000000000322,https://pubmed.ncbi.nlm.nih.gov/28099206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP126,ENSG00000188931,Unsafe,27412250,Targeting insulin-producing beta cells for regenerative therapy.,2016,10.1007/s00125-016-3949-9,https://pubmed.ncbi.nlm.nih.gov/27412250/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP126,ENSG00000188931,Unsafe,22275255,Increased gene dosage of myelin protein zero causes Charcot-Marie-Tooth disease.,2012,10.1002/ana.22658,https://pubmed.ncbi.nlm.nih.gov/22275255/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP126,ENSG00000188931,Unsafe,36191189,SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.,2022,10.1073/pnas.2207605119,https://pubmed.ncbi.nlm.nih.gov/36191189/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP141,ENSG00000163263,Unsafe,36191189,SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.,2022,10.1073/pnas.2207605119,https://pubmed.ncbi.nlm.nih.gov/36191189/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP144P1,ENSG00000164556,Unsafe,39366996,Pre-ciliated tubal epithelial cells are prone to initiation of high-grade serous ovarian carcinoma.,2024,10.1038/s41467-024-52984-1,https://pubmed.ncbi.nlm.nih.gov/39366996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP144P1,ENSG00000164556,Unsafe,30279523,The evolutionary conserved FOXJ1 target gene Fam183b is essential for motile cilia in Xenopus but dispensable for ciliary function in mice.,2018,10.1038/s41598-018-33045-2,https://pubmed.ncbi.nlm.nih.gov/30279523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP144P1,ENSG00000164556,Unsafe,30183206,Integrated analysis of differentially expressed lncRNAs in Medial Temporal Lobe Epilepsy.,2018,,https://pubmed.ncbi.nlm.nih.gov/30183206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP144P1,ENSG00000164556,Unsafe,27914912,Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse.,2017,10.1016/j.ydbio.2016.11.019,https://pubmed.ncbi.nlm.nih.gov/27914912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP20DC,ENSG00000163689,Unsafe,41497680,Novel homozygous &lt;i&gt;C3orf67&lt;/i&gt; gene variant associated with primary ciliary dyskinesia in a Saudi pediatric patient: A case report.,2025,10.5493/wjem.v15.i4.108404,https://pubmed.ncbi.nlm.nih.gov/41497680/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP20DC,ENSG00000163689,Unsafe,41224705,Beyond bacteria and breaking the norm: Pulmonary mucormycosis due to &lt;i&gt;Absidia corymbifera&lt;/i&gt; in a child with primary ciliary dyskinesia.,2025,10.1177/03000605251381480,https://pubmed.ncbi.nlm.nih.gov/41224705/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP20DC,ENSG00000163689,Unsafe,35787669,Ginsenoside Rh2 Regulates the CFAP20DC-AS1/MicroRNA-3614-3p/BBX and TNFAIP3 Axis to Induce Apoptosis in Breast Cancer Cells.,2022,10.1142/s0192415x22500720,https://pubmed.ncbi.nlm.nih.gov/35787669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP20DC,ENSG00000163689,Unsafe,31645124,Ginsenoside Rh2 Suppresses Breast Cancer Cell Proliferation by Epigenetically Regulating the Long Noncoding RNA C3orf67-AS1.,2019,10.1142/s0192415x19500848,https://pubmed.ncbi.nlm.nih.gov/31645124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP20DC,ENSG00000163689,Unsafe,32489448,Survival Risk Prediction Models of Gliomas Based on IDH and 1p/19q.,2020,10.7150/jca.43805,https://pubmed.ncbi.nlm.nih.gov/32489448/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP210,ENSG00000154479,Unsafe,42902429,Unraveling circRNAs and ceRNA regulatory networks underlying sex-specific gametogenesis impairment in triploid Pacific oysters (Crassostrea gigas).,2026,10.1186/s13293-026-00958-x,https://pubmed.ncbi.nlm.nih.gov/42902429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP210,ENSG00000154479,Unsafe,41074104,Saliva as a potential and non-invasive approach to identify upregulated genes associated with comorbidities of T1DM: a brief report.,2025,10.1186/s40001-025-03105-1,https://pubmed.ncbi.nlm.nih.gov/41074104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP210,ENSG00000154479,Unsafe,37995075,Microbiota Alters and Its Correlation with Molecular Regulation Underlying Depression in PCOS Patients.,2024,10.1007/s12035-023-03744-7,https://pubmed.ncbi.nlm.nih.gov/37995075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP210,ENSG00000154479,Unsafe,36191189,SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.,2022,10.1073/pnas.2207605119,https://pubmed.ncbi.nlm.nih.gov/36191189/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP263,ENSG00000103021,Unsafe,41645397,Loss-of-function mutations in Ccdc113 cause male infertility in both humans and mice.,2026,10.4103/aja202585,https://pubmed.ncbi.nlm.nih.gov/41645397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP263,ENSG00000103021,Unsafe,42117808,A Novel Circular RNA circSPEF2 Regulates Testis Development in Crucian Carp.,2026,10.3390/biology15090669,https://pubmed.ncbi.nlm.nih.gov/42117808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP263,ENSG00000103021,Unsafe,39671309,CCDC113 stabilizes sperm axoneme and head-tail coupling apparatus to ensure male fertility.,2024,10.7554/elife.98016,https://pubmed.ncbi.nlm.nih.gov/39671309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP263,ENSG00000103021,Unsafe,39261464,CCDC113 promotes colorectal cancer tumorigenesis and metastasis via TGF-β signaling pathway.,2024,10.1038/s41419-024-07036-3,https://pubmed.ncbi.nlm.nih.gov/39261464/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP263,ENSG00000103021,Unsafe,40356234,Genetics of Childhood-Onset Systemic Lupus Erythematosus.,2025,10.1002/art.43227,https://pubmed.ncbi.nlm.nih.gov/40356234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP263,ENSG00000103021,Unsafe,38006387,A robust mRNA signature obtained via recursive ensemble feature selection predicts the responsiveness of omalizumab in moderate-to-severe asthma.,2023,10.1002/clt2.12306,https://pubmed.ncbi.nlm.nih.gov/38006387/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP263,ENSG00000103021,Unsafe,39676709,Cross-Phenotype Genome-Wide Association Study on the Shared Genetic Susceptibility to Systemic Sclerosis and Primary Biliary Cholangitis.,2025,10.1002/art.43081,https://pubmed.ncbi.nlm.nih.gov/39676709/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP263,ENSG00000103021,Unsafe,33661892,"Ccdc113/Ccdc96 complex, a novel regulator of ciliary beating that connects radial spoke 3 to dynein g and the nexin link.",2021,10.1371/journal.pgen.1009388,https://pubmed.ncbi.nlm.nih.gov/33661892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP263,ENSG00000103021,Unsafe,35923697,Looking for the Genes Related to Lung Cancer From Nasal Epithelial Cells by Network and Pathway Analysis.,2022,10.3389/fgene.2022.942864,https://pubmed.ncbi.nlm.nih.gov/35923697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP263,ENSG00000103021,Unsafe,34280480,Different combinations of high-frequency rTMS and cognitive training improve the cognitive function of cerebral ischemic rats.,2021,10.1016/j.brainresbull.2021.07.012,https://pubmed.ncbi.nlm.nih.gov/34280480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP263,ENSG00000103021,Unsafe,25074808,Proteomic analysis of mammalian sperm cells identifies new components of the centrosome.,2014,10.1242/jcs.157008,https://pubmed.ncbi.nlm.nih.gov/25074808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP298,ENSG00000159079,Unsafe,40955177,A conserved domain of Cfap298 governs left-right symmetry breaking in vertebrates.,2025,10.1242/jcs.264129,https://pubmed.ncbi.nlm.nih.gov/40955177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP298,ENSG00000159079,Unsafe,40106351,&lt;i&gt;Chlamydomonas&lt;/i&gt; FBB18 is a ubiquitin-like protein essential for the cytoplasmic preassembly of various ciliary dyneins.,2025,10.1073/pnas.2423948122,https://pubmed.ncbi.nlm.nih.gov/40106351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP298,ENSG00000159079,Unsafe,38612805,Proteomic Analyses Reveal the Role of Alpha-2-Macroglobulin in Canine Osteosarcoma Cell Migration.,2024,10.3390/ijms25073989,https://pubmed.ncbi.nlm.nih.gov/38612805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP298,ENSG00000159079,Unsafe,33795825,The orthopedic characterization of cfap298tm304 mutants validate zebrafish to faithfully model human AIS.,2021,10.1038/s41598-021-86856-1,https://pubmed.ncbi.nlm.nih.gov/33795825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP298,ENSG00000159079,Unsafe,36026524,FBB18 participates in preassembly of almost all axonemal dyneins independent of R2TP complex.,2022,10.1371/journal.pgen.1010374,https://pubmed.ncbi.nlm.nih.gov/36026524/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP298,ENSG00000159079,Unsafe,34341445,Author Correction: The orthopedic characterization of cfap298tm304 mutants validate zebrafish to faithfully model human AIS.,2021,10.1038/s41598-021-95273-3,https://pubmed.ncbi.nlm.nih.gov/34341445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP298,ENSG00000159079,Unsafe,29601588,ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms.,2018,10.1371/journal.pgen.1007316,https://pubmed.ncbi.nlm.nih.gov/29601588/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP298,ENSG00000159079,Unsafe,33193130,"Morpholino-Mediated Knockdown of Ciliary Genes in Euplotes vannus, a Novel Marine Ciliated Model Organism.",2020,10.3389/fmicb.2020.549781,https://pubmed.ncbi.nlm.nih.gov/33193130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP298,ENSG00000159079,Unsafe,26904945,c21orf59/kurly Controls Both Cilia Motility and Polarization.,2016,10.1016/j.celrep.2016.01.069,https://pubmed.ncbi.nlm.nih.gov/26904945/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP298,ENSG00000159079,Unsafe,24094744,Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia.,2013,10.1016/j.ajhg.2013.08.015,https://pubmed.ncbi.nlm.nih.gov/24094744/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP298,ENSG00000159079,Unsafe,34139218,Extending the Horizon of Homology Detection with Coevolution-based Structure Prediction.,2021,10.1016/j.jmb.2021.167106,https://pubmed.ncbi.nlm.nih.gov/34139218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP298,ENSG00000159079,Unsafe,30228263,Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature.,2018,10.1038/s41467-018-06225-x,https://pubmed.ncbi.nlm.nih.gov/30228263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP298,ENSG00000159079,Unsafe,28410202,Identification of C21orf59 and ATG2A as novel determinants of renal function-related traits in Japanese by exome-wide association studies.,2017,10.18632/oncotarget.16696,https://pubmed.ncbi.nlm.nih.gov/28410202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP298,ENSG00000159079,Unsafe,25802884,Carrier frequencies of eleven mutations in eight genes associated with primary ciliary dyskinesia in the Ashkenazi Jewish population.,2015,10.1002/mgg3.124,https://pubmed.ncbi.nlm.nih.gov/25802884/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP298,ENSG00000159079,Unsafe,29113320,Identification of five genetic variants as novel determinants of type 2 diabetes mellitus in Japanese by exome-wide association studies.,2017,10.18632/oncotarget.19287,https://pubmed.ncbi.nlm.nih.gov/29113320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP299,ENSG00000197826,Unsafe,42795422,Genetic Variation and Haplotype Structure of &lt;i&gt;CFAP299&lt;/i&gt; and &lt;i&gt;PRDM8&lt;/i&gt; Associated with Fiber Yield and Hair Length Traits in Tianzhu White Yak.,2026,10.3390/life16091559,https://pubmed.ncbi.nlm.nih.gov/42795422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP299,ENSG00000197826,Unsafe,41897845,Genome-Wide Identification of Genomic Regions Associated with Body Weight and Morphometric Traits in Awassi Sheep.,2026,10.3390/ani16060867,https://pubmed.ncbi.nlm.nih.gov/41897845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP299,ENSG00000197826,Unsafe,41750351,Genome-Wide Association Study of Gross Hair Weight and Hair Length Traits in Different Body Regions of Tianzhu White Yak.,2026,10.3390/biom16020282,https://pubmed.ncbi.nlm.nih.gov/41750351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP299,ENSG00000197826,Unsafe,30820741,Cloning of a new testis-enriched gene C4orf22 and its role in cell cycle and apoptosis in mouse spermatogenic cells.,2019,10.1007/s11033-019-04651-8,https://pubmed.ncbi.nlm.nih.gov/30820741/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP299,ENSG00000197826,Unsafe,35360871,Resequencing and Signatures of Selective Scans Point to Candidate Genetic Variants for Hair Length Traits in Long-Haired and Normal-Haired Tianzhu White Yak.,2022,10.3389/fgene.2022.798076,https://pubmed.ncbi.nlm.nih.gov/35360871/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP300,ENSG00000137691,Unsafe,42067934,Cfap300 regulates the transdifferentiation of Corpuscle of Stannius cells in zebrafish.,2026,10.1186/s12964-026-02912-1,https://pubmed.ncbi.nlm.nih.gov/42067934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP300,ENSG00000137691,Unsafe,40806783,CFAP300 Loss-of-Function Mutations with Primary Ciliary Dyskinesia: Evidence from Ex Vivo and ALI Cultures.,2025,10.3390/ijms26157655,https://pubmed.ncbi.nlm.nih.gov/40806783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP300,ENSG00000137691,Unsafe,40898687,CFAP300 loss-of-function variant causes primary ciliary dyskinesia and male infertility via disrupting sperm flagellar assembly and acrosome formation.,2025,10.4103/aja202556,https://pubmed.ncbi.nlm.nih.gov/40898687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP300,ENSG00000137691,Unsafe,39254424,A novel homozygous mutation of CFAP300 identified in a Chinese patient with primary ciliary dyskinesia and infertility.,2025,10.4103/aja202477,https://pubmed.ncbi.nlm.nih.gov/39254424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP300,ENSG00000137691,Unsafe,36246608,CFAP300 mutation causing primary ciliary dyskinesia in Finland.,2022,10.3389/fgene.2022.985227,https://pubmed.ncbi.nlm.nih.gov/36246608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP300,ENSG00000137691,Unsafe,41373829,Heterogeneity of Primary Ciliary Dyskinesia Gene Variants: A Genetic Database Analysis in Russia.,2025,10.3390/ijms262311674,https://pubmed.ncbi.nlm.nih.gov/41373829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP300,ENSG00000137691,Unsafe,40670315,The Ultrasound and Genetic Characteristics of Fetuses With Laterality Defects-A Prenatal Cohort in Asian Population.,2025,10.1002/pd.6857,https://pubmed.ncbi.nlm.nih.gov/40670315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP300,ENSG00000137691,Unsafe,33635866,Defects in the cytoplasmic assembly of axonemal dynein arms cause morphological abnormalities and dysmotility in sperm cells leading to male infertility.,2021,10.1371/journal.pgen.1009306,https://pubmed.ncbi.nlm.nih.gov/33635866/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP300,ENSG00000137691,Unsafe,29727692,C11orf70 Mutations Disrupting the Intraflagellar Transport-Dependent Assembly of Multiple Axonemal Dyneins Cause Primary Ciliary Dyskinesia.,2018,10.1016/j.ajhg.2018.03.024,https://pubmed.ncbi.nlm.nih.gov/29727692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP300,ENSG00000137691,Unsafe,30916986,CFAP300: Mutations in Slavic Patients with Primary Ciliary Dyskinesia and a Role in Ciliary Dynein Arms Trafficking.,2019,10.1165/rcmb.2018-0260oc,https://pubmed.ncbi.nlm.nih.gov/30916986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP300,ENSG00000137691,Unsafe,39180133,Characterization of pathogenic genetic variants in Russian patients with primary ciliary dyskinesia using gene panel sequencing and transcript analysis.,2024,10.1186/s13023-024-03318-3,https://pubmed.ncbi.nlm.nih.gov/39180133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP300,ENSG00000137691,Unsafe,29727693,Mutations in C11orf70 Cause Primary Ciliary Dyskinesia with Randomization of Left/Right Body Asymmetry Due to Defects of Outer and Inner Dynein Arms.,2018,10.1016/j.ajhg.2018.03.025,https://pubmed.ncbi.nlm.nih.gov/29727693/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP300,ENSG00000137691,Unsafe,19041365,"TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours.",2009,10.1016/j.mce.2008.10.043,https://pubmed.ncbi.nlm.nih.gov/19041365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,41220226,SmallTalk: a novel small-sized fusion tag for peptide expression and purification.,2026,10.1002/2211-5463.70147,https://pubmed.ncbi.nlm.nih.gov/41220226/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,42311504,Clinical heterogeneity associated with Bardet-Biedl syndrome-related genes in presumed non-syndromic inherited retinal disease.,2026,10.3389/fcell.2026.1802945,https://pubmed.ncbi.nlm.nih.gov/42311504/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,37971880,Disruption of CFAP418 interaction with lipids causes widespread abnormal membrane-associated cellular processes in retinal degenerations.,2024,10.1172/jci.insight.162621,https://pubmed.ncbi.nlm.nih.gov/37971880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,41021661,Identifying genetic determinants of outer retinal function in mice using a large-scale gene-targeted screen.,2025,10.1371/journal.pgen.1011886,https://pubmed.ncbi.nlm.nih.gov/41021661/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,36233334,"Interactions between C8orf37 and FAM161A, Two Ciliary Proteins Essential for Photoreceptor Survival.",2022,10.3390/ijms231912033,https://pubmed.ncbi.nlm.nih.gov/36233334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,34440463,siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference.,2021,10.3390/genes12081290,https://pubmed.ncbi.nlm.nih.gov/34440463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,41153400,Inherited Retinal Diseases with High Myopia: A Review.,2025,10.3390/genes16101183,https://pubmed.ncbi.nlm.nih.gov/41153400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,37170250,"A nonsense mutation in C8orf37 linked with retinitis pigmentosa, early macular degeneration, cataract, and myopia in an arRP family from North India.",2023,10.1186/s12886-023-02936-y,https://pubmed.ncbi.nlm.nih.gov/37170250/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,37996899,Retinal nerve fibre layer thinning and corneal nerve loss in patients with Bardet-Biedl syndrome.,2023,10.1186/s12920-023-01739-w,https://pubmed.ncbi.nlm.nih.gov/37996899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,29440555,C8ORF37 Is Required for Photoreceptor Outer Segment Disc Morphogenesis by Maintaining Outer Segment Membrane Protein Homeostasis.,2018,10.1523/jneurosci.2964-17.2018,https://pubmed.ncbi.nlm.nih.gov/29440555/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,27008867,Mutations in C8ORF37 cause Bardet Biedl syndrome (BBS21).,2016,10.1093/hmg/ddw096,https://pubmed.ncbi.nlm.nih.gov/27008867/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,22177090,"Mutations in C8orf37, encoding a ciliary protein, are associated with autosomal-recessive retinal dystrophies with early macular involvement.",2012,10.1016/j.ajhg.2011.11.015,https://pubmed.ncbi.nlm.nih.gov/22177090/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,25802487,Novel C8orf37 mutations cause retinitis pigmentosa in consanguineous families of Pakistani origin.,2015,,https://pubmed.ncbi.nlm.nih.gov/25802487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,26690675,Identification of epistatic interactions through genome-wide association studies in sporadic medullary and juvenile papillary thyroid carcinomas.,2015,10.1186/s12920-015-0160-7,https://pubmed.ncbi.nlm.nih.gov/26690675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,29843741,Distinct mutations with different inheritance mode caused similar retinal dystrophies in one family: a demonstration of the importance of genetic annotations in complicated pedigrees.,2018,10.1186/s12967-018-1522-7,https://pubmed.ncbi.nlm.nih.gov/29843741/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,27255588,Enhancing the early home learning environment through a brief group parenting intervention: study protocol for a cluster randomised controlled trial.,2016,10.1186/s12887-016-0610-1,https://pubmed.ncbi.nlm.nih.gov/27255588/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,29958078,Identification of nine novel loci related to hematological traits in a Japanese population.,2018,10.1152/physiolgenomics.00088.2017,https://pubmed.ncbi.nlm.nih.gov/29958078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,25515582,Whole exome sequencing reveals GUCY2D as a major gene associated with cone and cone-rod dystrophy in Israel.,2014,10.1167/iovs.14-15647,https://pubmed.ncbi.nlm.nih.gov/25515582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,1368919,Object-oriented fuzzy expert system for on-line diagnosing and control of bioprocesses.,1992,10.1007/bf00174842,https://pubmed.ncbi.nlm.nih.gov/1368919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,39359116,An early parenting intervention focused on enriched parent-child interactions improves effortful control in the early years of school.,2025,10.1111/cdev.14166,https://pubmed.ncbi.nlm.nih.gov/39359116/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,38435575,Synergizing language learning: SmallTalk AI In industry 4.0 and Education 4.0.,2024,10.7717/peerj-cs.1843,https://pubmed.ncbi.nlm.nih.gov/38435575/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,28108927,Impact of a Brief Group Intervention to Enhance Parenting and the Home Learning Environment for Children Aged 6-36 Months: a Cluster Randomised Controlled Trial.,2017,10.1007/s11121-017-0753-9,https://pubmed.ncbi.nlm.nih.gov/28108927/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP418,ENSG00000156172,Unsafe,29720124,EHLS at School: school-age follow-up of the Early Home Learning Study cluster randomized controlled trial.,2018,10.1186/s12887-018-1122-y,https://pubmed.ncbi.nlm.nih.gov/29720124/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,42791792,Genome-Wide Analysis of DNA Methylation Profiles on Jining Grey Goat Uterus Associated with Prolificacy Using Whole-Genome Bisulfite Sequencing.,2026,10.3390/ani16182935,https://pubmed.ncbi.nlm.nih.gov/42791792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,41549427,Novel biallelic CFAP43 mutations induce MMAF with mitochondrial abnormalities and successful ICSI outcomes.,2026,10.4103/aja202565,https://pubmed.ncbi.nlm.nih.gov/41549427/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,41341611,Expanding the phenotypic spectrum associated with &lt;i&gt;CFAP43&lt;/i&gt; mutations: a case report of familial male infertility with respiratory manifestations.,2025,10.3389/frph.2025.1609938,https://pubmed.ncbi.nlm.nih.gov/41341611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,39572557,CFAP43 variant in persistent respiratory symptoms after hematopoietic cell transplantation.,2024,10.1038/s41439-024-00298-5,https://pubmed.ncbi.nlm.nih.gov/39572557/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,39331878,Single nucleotide polymorphisms of CFAP43 and TEX14 associated with idiopathic male infertility in a Vietnamese population.,2024,10.1097/md.0000000000039839,https://pubmed.ncbi.nlm.nih.gov/39331878/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,40751857,Multi-omics and Mendelian randomization study explores potential therapeutic targets for meningiomas.,2025,10.1007/s12672-025-03318-0,https://pubmed.ncbi.nlm.nih.gov/40751857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,41398643,Mining of candidate genes related to prolificacy in Jining grey goats using transcriptomics.,2025,10.1186/s12864-025-12284-4,https://pubmed.ncbi.nlm.nih.gov/41398643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,41264116,The essential role of cytoskeleton and ciliary abnormalities in the development of congenital pulmonary airway malformations.,2025,10.1007/s00383-025-06250-0,https://pubmed.ncbi.nlm.nih.gov/41264116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,40376536,Establishment and clinical significance of genetic factor screening method for patients with nonobstructive azoospermia based on whole exon sequencing technology.,2025,10.21037/tau-2024-676,https://pubmed.ncbi.nlm.nih.gov/40376536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,40266017,Genetic Risk Factors in Normal Pressure Hydrocephalus: What We Know and What Is Next.,2025,10.1002/mds.30206,https://pubmed.ncbi.nlm.nih.gov/40266017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,38956598,Impact of aquaporin-4 and CD11c + microglia in the development of ependymal cells in the aqueduct: inferences to hydrocephalus.,2024,10.1186/s12987-024-00548-2,https://pubmed.ncbi.nlm.nih.gov/38956598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,36960497,Patients with MMAF induced by novel biallelic CFAP43 mutations have good fertility outcomes after intracytoplasmic sperm injection.,2023,10.4103/aja2022118,https://pubmed.ncbi.nlm.nih.gov/36960497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,34100391,Novel biallelic loss-of-function mutations in CFAP43 cause multiple morphological abnormalities of the sperm flagellum in Pakistani families.,2021,10.4103/aja.aja_26_21,https://pubmed.ncbi.nlm.nih.gov/34100391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,40326273,Transcriptomic Features of Recurrence Rates in Idiopathic Subglottic Stenosis.,2025,10.1002/lary.32214,https://pubmed.ncbi.nlm.nih.gov/40326273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,36552367,Relationships between the Mini-InDel Variants within the Goat CFAP43 Gene and Body Traits.,2022,10.3390/ani12243447,https://pubmed.ncbi.nlm.nih.gov/36552367/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,41070383,Identification of copy number variations through whole genome resequencing between Jiuyishan and Hyplus rabbits.,2025,10.3389/fvets.2025.1612883,https://pubmed.ncbi.nlm.nih.gov/41070383/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,31004071,Nonsense mutation in CFAP43 causes normal-pressure hydrocephalus with ciliary abnormalities.,2019,10.1212/wnl.0000000000007505,https://pubmed.ncbi.nlm.nih.gov/31004071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,38540412,Genome-Wide DNA Methylation Analysis and Functional Validation of Litter Size Traits in Jining Grey Goats.,2024,10.3390/genes15030353,https://pubmed.ncbi.nlm.nih.gov/38540412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,37534326,Analysis of ceRNA Regulatory Mechanism of Rape Pollen Allergy Based on Whole-Transcriptome Sequencing of Peripheral Blood Mononuclear Cells.,2023,10.2147/jaa.s416772,https://pubmed.ncbi.nlm.nih.gov/37534326/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,38505001,Copy number variants selected during pig domestication inferred from whole genome resequencing.,2024,10.3389/fvets.2024.1364267,https://pubmed.ncbi.nlm.nih.gov/38505001/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,34529793,"Genetic diagnosis, sperm phenotype and ICSI outcome in case of severe asthenozoospermia with multiple morphological abnormalities of the flagellum.",2021,10.1093/humrep/deab200,https://pubmed.ncbi.nlm.nih.gov/34529793/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP43,ENSG00000197748,Unsafe,29449551,Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human.,2018,10.1038/s41467-017-02792-7,https://pubmed.ncbi.nlm.nih.gov/29449551/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,42371530,A Novel Deep-Intronic &lt;i&gt;CFAP44&lt;/i&gt; Variant Underlies Multiple Morphological Abnormalities of the Sperm Flagella.,2026,10.2147/tacg.s609696,https://pubmed.ncbi.nlm.nih.gov/42371530/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,42072084,Transcriptomic Analysis of Fermented Chinese Chive Selectively Attenuating Deoxynivalenol-Induced Ovarian Toxicity in Mice.,2026,10.3390/antiox15040442,https://pubmed.ncbi.nlm.nih.gov/42072084/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,41052974,Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants.,2025,10.1038/s41398-025-03578-y,https://pubmed.ncbi.nlm.nih.gov/41052974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,40311472,BDE-209 toxicity: From spermiogenesis to sexual maturity in F1 male mice.,2025,10.1016/j.ecoenv.2025.118231,https://pubmed.ncbi.nlm.nih.gov/40311472/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,35470451,Reduced expression of CFAP44 and CFAP44-AS1 may affect sperm motility and morphology.,2022,10.1111/and.14447,https://pubmed.ncbi.nlm.nih.gov/35470451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,35886074,Further Insights on RNA Expression and Sperm Motility.,2022,10.3390/genes13071291,https://pubmed.ncbi.nlm.nih.gov/35886074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,34100391,Novel biallelic loss-of-function mutations in CFAP43 cause multiple morphological abnormalities of the sperm flagellum in Pakistani families.,2021,10.4103/aja.aja_26_21,https://pubmed.ncbi.nlm.nih.gov/34100391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,31932510,"LAX28 is required for the stable assembly of the inner dynein arm f complex, and the tether and tether head complex in Leishmania flagella.",2020,10.1242/jcs.239855,https://pubmed.ncbi.nlm.nih.gov/31932510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,31901658,Fluoride exposure alters the ultra-structure of sperm flagellum via reducing key protein expressions in testis.,2020,10.1016/j.chemosphere.2019.125772,https://pubmed.ncbi.nlm.nih.gov/31901658/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,28552195,Biallelic Mutations in CFAP43 and CFAP44 Cause Male Infertility with Multiple Morphological Abnormalities of the Sperm Flagella.,2017,10.1016/j.ajhg.2017.04.012,https://pubmed.ncbi.nlm.nih.gov/28552195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,34089056,Exome sequencing reveals variants in known and novel candidate genes for severe sperm motility disorders.,2021,10.1093/humrep/deab099,https://pubmed.ncbi.nlm.nih.gov/34089056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,29449551,Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human.,2018,10.1038/s41467-017-02792-7,https://pubmed.ncbi.nlm.nih.gov/29449551/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,30122540,A Homozygous Ancestral SVA-Insertion-Mediated Deletion in WDR66 Induces Multiple Morphological Abnormalities of the Sperm Flagellum and Male Infertility.,2018,10.1016/j.ajhg.2018.07.014,https://pubmed.ncbi.nlm.nih.gov/30122540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,37392679,Mechanisms of damage to sperm structure in mice on the zinc-deficient diet.,2023,10.1016/j.jtemb.2023.127251,https://pubmed.ncbi.nlm.nih.gov/37392679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,37001189,Microcystin leucine arginine induces human sperm damage: Involvement of the Ca2+/CaMKKβ/AMPK pathway.,2023,10.1016/j.ecoenv.2023.114845,https://pubmed.ncbi.nlm.nih.gov/37001189/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,29277146,Novel Mutations in CFAP44 and CFAP43 Cause Multiple Morphological Abnormalities of the Sperm Flagella (MMAF).,2019,10.1177/1933719117749756,https://pubmed.ncbi.nlm.nih.gov/29277146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,28887034,"A novel gene, cilia flagella associated protein 44, encoding an enzyme cleaving FtsZ and tubulin contributes to the regulation of secretory pathway.",2017,10.1016/j.bbrc.2017.09.010,https://pubmed.ncbi.nlm.nih.gov/28887034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,30904354,NovelCFAP43 andCFAP44 mutations cause male infertility with multiple morphological abnormalities of the sperm flagella (MMAF).,2019,10.1016/j.rbmo.2018.12.037,https://pubmed.ncbi.nlm.nih.gov/30904354/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,30137358,Whole-exome sequencing identifies mutations in FSIP2 as a recurrent cause of multiple morphological abnormalities of the sperm flagella.,2018,10.1093/humrep/dey264,https://pubmed.ncbi.nlm.nih.gov/30137358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,30867909,Genetic causes of male infertility: snapshot on morphological abnormalities of the sperm flagellum.,2019,10.1186/s12610-019-0083-9,https://pubmed.ncbi.nlm.nih.gov/30867909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,32460071,Chronic arsenic exposure lowered sperm motility via impairing ultra-microstructure and key proteins expressions of sperm acrosome and flagellum formation during spermiogenesis in male mice.,2020,10.1016/j.scitotenv.2020.139233,https://pubmed.ncbi.nlm.nih.gov/32460071/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,34529793,"Genetic diagnosis, sperm phenotype and ICSI outcome in case of severe asthenozoospermia with multiple morphological abnormalities of the flagellum.",2021,10.1093/humrep/deab200,https://pubmed.ncbi.nlm.nih.gov/34529793/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP44,ENSG00000206530,Unsafe,25089948,Ancestry and other genetic associations with plasma PCSK9 response to simvastatin.,2014,10.1097/fpc.0000000000000081,https://pubmed.ncbi.nlm.nih.gov/25089948/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,42375853,Association of serum coiled-coil domain containing protein 11 levels with coronary artery disease.,2026,10.3389/fcvm.2026.1818052,https://pubmed.ncbi.nlm.nih.gov/42375853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,39479942,The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation.,2025,10.1002/cm.21952,https://pubmed.ncbi.nlm.nih.gov/39479942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,41869134,Novel Compound Heterozygous CFAP53 Variants in a Fetus With Situs Inversus Totalis: A Case Report.,2026,10.7759/cureus.103723,https://pubmed.ncbi.nlm.nih.gov/41869134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,42743277,FAP53 facilitates formation of microtubule doublets.,2026,10.1073/pnas.2531822123,https://pubmed.ncbi.nlm.nih.gov/42743277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,41559780,"A telomere-based prognostic model incorporating E2F1, MYCN, VPS72, CFAP53, OR8A1, and TXNRD1 for hepatocellular carcinoma.",2026,10.1186/s40001-026-03900-4,https://pubmed.ncbi.nlm.nih.gov/41559780/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,41759193,HDAC6 interacting-microtubule associated proteins (HMAPs) identified in human sperm.,2026,10.1080/19396368.2026.2631565,https://pubmed.ncbi.nlm.nih.gov/41759193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,34124066,Essential Role of CFAP53 in Sperm Flagellum Biogenesis.,2021,10.3389/fcell.2021.676910,https://pubmed.ncbi.nlm.nih.gov/34124066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,33347437,CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.,2020,10.1371/journal.pgen.1009232,https://pubmed.ncbi.nlm.nih.gov/33347437/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,35980365,The centriolar satellite protein Cfap53 facilitates formation of the zygotic microtubule organizing center in the zebrafish embryo.,2022,10.1242/dev.198762,https://pubmed.ncbi.nlm.nih.gov/35980365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,32251302,Transcriptomic analysis of female and male gonads in juvenile snakeskin gourami (Trichopodus pectoralis).,2020,10.1038/s41598-020-61738-0,https://pubmed.ncbi.nlm.nih.gov/32251302/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,28621423,Roles of the cilium-associated gene CCDC11 in left-right patterning and in laterality disorders in humans.,2017,10.1387/ijdb.160442yc,https://pubmed.ncbi.nlm.nih.gov/28621423/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,35282133,Development of a prognostic nomogram based on an eight-gene signature for esophageal squamous cell carcinoma by weighted gene co-expression network analysis (WGCNA).,2022,10.21037/atm-21-6935,https://pubmed.ncbi.nlm.nih.gov/35282133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,26538025,Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry.,2016,10.1091/mbc.e15-07-0474,https://pubmed.ncbi.nlm.nih.gov/26538025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,26531781,A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ Function.,2016,10.1002/humu.22928,https://pubmed.ncbi.nlm.nih.gov/26531781/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,34556108,Whole genome sequencing in the diagnosis of primary ciliary dyskinesia.,2021,10.1186/s12920-021-01084-w,https://pubmed.ncbi.nlm.nih.gov/34556108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,28911167,In Utero Exposure to a High-Fat Diet Programs Hepatic Hypermethylation and Gene Dysregulation and Development of Metabolic Syndrome in Male Mice.,2017,10.1210/en.2017-00334,https://pubmed.ncbi.nlm.nih.gov/28911167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,22577226,A human laterality disorder associated with recessive CCDC11 mutation.,2012,10.1136/jmedgenet-2011-100457,https://pubmed.ncbi.nlm.nih.gov/22577226/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,31264263,Dysregulation of sputum columnar epithelial cells and products in distinct asthma phenotypes.,2019,10.1111/cea.13452,https://pubmed.ncbi.nlm.nih.gov/31264263/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,17523142,Scanning copy number and gene expression on the 18q21-qter chromosomal region by the systematic multiplex PCR and reverse transcription-PCR methods.,2007,10.1002/elps.200700093,https://pubmed.ncbi.nlm.nih.gov/17523142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,36191189,SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.,2022,10.1073/pnas.2207605119,https://pubmed.ncbi.nlm.nih.gov/36191189/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP53,ENSG00000172361,Unsafe,25504577,"Mutations in CCDC11, which encodes a coiled-coil containing ciliary protein, causes situs inversus due to dysmotility of monocilia in the left-right organizer.",2015,10.1002/humu.22738,https://pubmed.ncbi.nlm.nih.gov/25504577/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP57,ENSG00000243710,Unsafe,41466333,"Mutations in CFAP57 disrupt the localization of MYH10 and IFT88, leading to flagellogenesis failure in humans and mice.",2025,10.1186/s40246-025-00859-x,https://pubmed.ncbi.nlm.nih.gov/41466333/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP57,ENSG00000243710,Unsafe,41793497,A novel CFAP57 nonsense mutation causes asthenozoospermia in a consanguineous Emirati family.,2026,10.1007/s11033-026-11657-6,https://pubmed.ncbi.nlm.nih.gov/41793497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP57,ENSG00000243710,Unsafe,40898283,DNAH10 mutation cause primary ciliary dyskinesia with defects of IDAf complex assembly and lung fibrosis manifestation.,2025,10.1186/s13023-025-03977-w,https://pubmed.ncbi.nlm.nih.gov/40898283/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP57,ENSG00000243710,Unsafe,39671309,CCDC113 stabilizes sperm axoneme and head-tail coupling apparatus to ensure male fertility.,2024,10.7554/elife.98016,https://pubmed.ncbi.nlm.nih.gov/39671309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP57,ENSG00000243710,Unsafe,36752199,Loss-of-function mutations in CFAP57 cause multiple morphological abnormalities of the flagella in humans and mice.,2023,10.1172/jci.insight.166869,https://pubmed.ncbi.nlm.nih.gov/36752199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP57,ENSG00000243710,Unsafe,40431640,Anthraquinone-2-Carboxylic Acid Is a Potential Antiviral Candidate Against Influenza Viruses In Vitro and In Vivo.,2025,10.3390/v17050628,https://pubmed.ncbi.nlm.nih.gov/40431640/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP57,ENSG00000243710,Unsafe,32764743,"Mutation of CFAP57, a protein required for the asymmetric targeting of a subset of inner dynein arms in Chlamydomonas, causes primary ciliary dyskinesia.",2020,10.1371/journal.pgen.1008691,https://pubmed.ncbi.nlm.nih.gov/32764743/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP57,ENSG00000243710,Unsafe,36091765,Whole-exome sequencing and bioinformatics analysis of a case of non-alpha-fetoprotein-elevated lung hepatoid adenocarcinoma.,2022,10.3389/fphar.2022.945038,https://pubmed.ncbi.nlm.nih.gov/36091765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP57,ENSG00000243710,Unsafe,36533556,Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants.,2022,10.1242/dmm.049568,https://pubmed.ncbi.nlm.nih.gov/36533556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP57,ENSG00000243710,Unsafe,34871736,Novel Machado-Joseph disease-modifying genes and pathways identified by whole-exome sequencing.,2022,10.1016/j.nbd.2021.105578,https://pubmed.ncbi.nlm.nih.gov/34871736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP57,ENSG00000243710,Unsafe,27486773,Integrated analysis miRNA and mRNA profiling in patients with severe oligozoospermia reveals miR-34c-3p downregulates PLCXD3 expression.,2016,10.18632/oncotarget.10947,https://pubmed.ncbi.nlm.nih.gov/27486773/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP57,ENSG00000243710,Unsafe,34400346,Proteomic Signature of Host Response to SARS-CoV-2 Infection in the Nasopharynx.,2021,10.1016/j.mcpro.2021.100134,https://pubmed.ncbi.nlm.nih.gov/34400346/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP57,ENSG00000243710,Unsafe,21574244,Genomic strategy identifies a missense mutation in WD-repeat domain 65 (WDR65) in an individual with Van der Woude syndrome.,2011,10.1002/ajmg.a.33980,https://pubmed.ncbi.nlm.nih.gov/21574244/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP57,ENSG00000243710,Unsafe,31483737,FAP57/WDR65 targets assembly of a subset of inner arm dyneins and connects to regulatory hubs in cilia.,2019,10.1091/mbc.e19-07-0367,https://pubmed.ncbi.nlm.nih.gov/31483737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP57,ENSG00000243710,Unsafe,22447971,Transcriptional targeting in the airway using novel gene regulatory elements.,2012,10.1165/rcmb.2011-0444oc,https://pubmed.ncbi.nlm.nih.gov/22447971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP58,ENSG00000120051,Unsafe,42799967,CFAP58-deficient human sperm show radial spoke-doublet microtubule interface abnormalities and successful fertilization by ICSI.,2026,10.1007/s10815-026-04036-4,https://pubmed.ncbi.nlm.nih.gov/42799967/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP58,ENSG00000120051,Unsafe,38837026,Whole exome sequencing analyses reveal novel genes in telomere length and their biomedical implications.,2024,10.1007/s11357-024-01203-2,https://pubmed.ncbi.nlm.nih.gov/38837026/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP58,ENSG00000120051,Unsafe,38602507,CFAP58 is involved in the sperm head shaping and flagellogenesis of cattle and mice.,2024,10.1242/dev.202608,https://pubmed.ncbi.nlm.nih.gov/38602507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP58,ENSG00000120051,Unsafe,40386064,Identification of an Anoikis-associated LncRNA Signature to Predict the Clinical Prognosis and Immune Function of Patients with Endometrial Cancer.,2025,10.7150/ijms.107243,https://pubmed.ncbi.nlm.nih.gov/40386064/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP58,ENSG00000120051,Unsafe,41882697,SIRT1 haploinsufficiency recapitulates age-associated subfertility through sperm α-tubulin hyperacetylation.,2026,10.1186/s13062-025-00710-2,https://pubmed.ncbi.nlm.nih.gov/41882697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP58,ENSG00000120051,Unsafe,40317966,Clinicopathological and molecular characterization of KRAS wild-type pancreatic ductal adenocarcinomas reveals precursor lesions with oncogenic mutations and fusions in RAS pathway genes.,2025,10.1002/path.6432,https://pubmed.ncbi.nlm.nih.gov/40317966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP58,ENSG00000120051,Unsafe,36846008,Ferroptosis-related lncRNA model based on CFAP58-DT for predicting prognosis and immunocytes infiltration in endometrial cancer.,2023,10.21037/atm-22-6659,https://pubmed.ncbi.nlm.nih.gov/36846008/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP58,ENSG00000120051,Unsafe,32791035,Bi-allelic Loss-of-function Variants in CFAP58 Cause Flagellar Axoneme and Mitochondrial Sheath Defects and Asthenoteratozoospermia in Humans and Mice.,2020,10.1016/j.ajhg.2020.07.010,https://pubmed.ncbi.nlm.nih.gov/32791035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP58,ENSG00000120051,Unsafe,31904090,The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis.,2020,10.1042/bsr20192666,https://pubmed.ncbi.nlm.nih.gov/31904090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP58,ENSG00000120051,Unsafe,38568782,The MBO2/FAP58 heterodimer stabilizes assembly of inner arm dynein &lt;i&gt;b&lt;/i&gt; and reveals axoneme asymmetries involved in ciliary waveform.,2024,10.1091/mbc.e23-11-0439,https://pubmed.ncbi.nlm.nih.gov/38568782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP58,ENSG00000120051,Unsafe,34089056,Exome sequencing reveals variants in known and novel candidate genes for severe sperm motility disorders.,2021,10.1093/humrep/deab099,https://pubmed.ncbi.nlm.nih.gov/34089056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP58,ENSG00000120051,Unsafe,35937391,Ferroptosis-Related lncRNA for the Establishment of Novel Prognostic Signature and Therapeutic Response Prediction to Endometrial Carcinoma.,2022,10.1155/2022/2056913,https://pubmed.ncbi.nlm.nih.gov/35937391/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP58,ENSG00000120051,Unsafe,35957871,The IFN-γ-related long non-coding RNA signature predicts prognosis and indicates immune microenvironment infiltration in uterine corpus endometrial carcinoma.,2022,10.3389/fonc.2022.955979,https://pubmed.ncbi.nlm.nih.gov/35957871/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP58,ENSG00000120051,Unsafe,33955803,Prediction of bladder cancer outcome by identifying and validating a mutation-derived genomic instability-associated long noncoding RNA (lncRNA) signature.,2021,10.1080/21655979.2021.1924555,https://pubmed.ncbi.nlm.nih.gov/33955803/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP58,ENSG00000120051,Unsafe,34173924,Immunogenomic profiling and pathological response results from a clinical trial of docetaxel and carboplatin in triple-negative breast cancer.,2021,10.1007/s10549-021-06307-3,https://pubmed.ncbi.nlm.nih.gov/34173924/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP58,ENSG00000120051,Unsafe,26762739,Focused Analysis of Exome Sequencing Data for Rare Germline Mutations in Familial and Sporadic Lung Cancer.,2016,10.1016/j.jtho.2015.09.015,https://pubmed.ncbi.nlm.nih.gov/26762739/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,42417609,Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia.,2026,10.7554/elife.110601,https://pubmed.ncbi.nlm.nih.gov/42417609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,37352829,CFAP70 is a solid and valuable target for the genetic diagnosis of oligo-astheno-teratozoospermia in infertile men.,2023,10.1016/j.ebiom.2023.104675,https://pubmed.ncbi.nlm.nih.gov/37352829/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,42890986,Maintenance of bone health by osteoblasts in the absence of osteocytes: comparative analysis of gene expression in medaka and zebrafish vertebrae.,2026,10.1016/j.bonr.2026.101953,https://pubmed.ncbi.nlm.nih.gov/42890986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,41264116,The essential role of cytoskeleton and ciliary abnormalities in the development of congenital pulmonary airway malformations.,2025,10.1007/s00383-025-06250-0,https://pubmed.ncbi.nlm.nih.gov/41264116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,39853433,CFAP65 is essential for C2a projection integrity in axonemes: implications for organ-specific ciliary dysfunction and infertility.,2025,10.1007/s00018-025-05583-2,https://pubmed.ncbi.nlm.nih.gov/39853433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,37458246,Experimental and molecular support for Cfap70 as a causative gene of 'multiple morphological abnormalities of the flagella' with male infertility†.,2023,10.1093/biolre/ioad076,https://pubmed.ncbi.nlm.nih.gov/37458246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,39092789,MYCBPAP is a central apparatus protein required for centrosome-nuclear envelope docking and sperm tail biogenesis in mice.,2024,10.1242/jcs.261962,https://pubmed.ncbi.nlm.nih.gov/39092789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,41778435,Potential Therapeutic Targets for Neuroblastoma Screened through Mendelian Randomization Analysis.,2025,10.34172/aim.35114,https://pubmed.ncbi.nlm.nih.gov/41778435/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,38891632,Integrated miRNA and mRNA Sequencing Reveals the Sterility Mechanism in Hybrid Yellow Catfish Resulting from Pelteobagrus fulvidraco (♀) × Pelteobagrus vachelli (♂).,2024,10.3390/ani14111586,https://pubmed.ncbi.nlm.nih.gov/38891632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,40231527,Cilia Plays a Pivotal Role in the Hypersecretion of Airway Mucus in Mice,2024,10.2174/0118761429368288250401054301,https://pubmed.ncbi.nlm.nih.gov/40231527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,34100391,Novel biallelic loss-of-function mutations in CFAP43 cause multiple morphological abnormalities of the sperm flagellum in Pakistani families.,2021,10.4103/aja.aja_26_21,https://pubmed.ncbi.nlm.nih.gov/34100391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,30158508,CFAP70 Is a Novel Axoneme-Binding Protein That Localizes at the Base of the Outer Dynein Arm and Regulates Ciliary Motility.,2018,10.3390/cells7090124,https://pubmed.ncbi.nlm.nih.gov/30158508/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,39358566,Comprehensive analysis of chromosomal breakpoints and candidate genes associated with male infertility: insights from cytogenetic studies and expression analyses.,2024,10.1007/s00335-024-10074-z,https://pubmed.ncbi.nlm.nih.gov/39358566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,39704931,"Homozygous deleterious variants in MYCBPAP induce asthenoteratozoospermia involving abnormal acrosome biogenesis, manchette structure and sperm tail assembly in humans and mice.",2025,10.1007/s11427-024-2757-7,https://pubmed.ncbi.nlm.nih.gov/39704931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,31621862,CFAP70 mutations lead to male infertility due to severe astheno-teratozoospermia. A case report.,2019,10.1093/humrep/dez166,https://pubmed.ncbi.nlm.nih.gov/31621862/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,31770211,Screening and identification of key biomarkers in nasopharyngeal carcinoma: Evidence from bioinformatic analysis.,2019,10.1097/md.0000000000017997,https://pubmed.ncbi.nlm.nih.gov/31770211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,33988244,Chlamydomonas FAP70 is a component of the previously uncharacterized ciliary central apparatus projection C2a.,2021,10.1242/jcs.258540,https://pubmed.ncbi.nlm.nih.gov/33988244/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,35484513,Identifying pleiotropic variants and candidate genes for fertility and reproduction traits in Holstein cattle via association studies based on imputed whole-genome sequence genotypes.,2022,10.1186/s12864-022-08555-z,https://pubmed.ncbi.nlm.nih.gov/35484513/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,36659204,Absence of murine CFAP61 causes male infertility due to multiple morphological abnormalities of the flagella.,2020,10.1016/j.scib.2020.01.023,https://pubmed.ncbi.nlm.nih.gov/36659204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP70,ENSG00000156042,Unsafe,27716579,"The transcription factor, Nuclear factor, erythroid 2 (Nfe2), is a regulator of the oxidative stress response during Danio rerio development.",2016,10.1016/j.aquatox.2016.09.019,https://pubmed.ncbi.nlm.nih.gov/27716579/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,40931011,Proximity labeling of axonemal protein CFAP91 identifies EFCAB5 that regulates sperm motility.,2025,10.1038/s41467-025-63705-7,https://pubmed.ncbi.nlm.nih.gov/40931011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,42187755,The &lt;i&gt;Ascosphaera apis&lt;/i&gt; Invasion of &lt;i&gt;Apis cerana&lt;/i&gt; Worker Larvae: Long Non-Coding RNA-Mediated Regulation.,2026,10.3390/biology15100793,https://pubmed.ncbi.nlm.nih.gov/42187755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,39671309,CCDC113 stabilizes sperm axoneme and head-tail coupling apparatus to ensure male fertility.,2024,10.7554/elife.98016,https://pubmed.ncbi.nlm.nih.gov/39671309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,40223932,Vascular smooth muscle cell-derived SO&lt;sub&gt;2&lt;/sub&gt; sulphenylated interferon regulatory factor 1 to inhibit VSMC senescence.,2025,10.3389/fphar.2025.1516885,https://pubmed.ncbi.nlm.nih.gov/40223932/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,41138304,Compensatory role of endogenous sulfur dioxide in hydrogen sulfide deficiency-induced microglial inflammation.,2025,10.1016/j.intimp.2025.115720,https://pubmed.ncbi.nlm.nih.gov/41138304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,41615597,Gene Expression Profiles of Amaranthin-Like Proteins with Distinct Domain Combinations in Flax (Linum usitatissimum).,2025,10.1134/s1607672925601325,https://pubmed.ncbi.nlm.nih.gov/41615597/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,36552811,Cfap91-Dependent Stability of the RS2 and RS3 Base Proteins and Adjacent Inner Dynein Arms in Tetrahymena Cilia.,2022,10.3390/cells11244048,https://pubmed.ncbi.nlm.nih.gov/36552811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,39892500,Sulfur dioxide controls M1 macrophage polarization by sulphenylation of prolyl hydroxylase 2 at cysteine 260.,2025,10.1016/j.freeradbiomed.2025.01.054,https://pubmed.ncbi.nlm.nih.gov/39892500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,38608729,Analysis of the expression of the Serpina1 gene in SARS-CoV-2 infection: study of a new biomarker.,2024,10.1016/j.rceng.2024.04.006,https://pubmed.ncbi.nlm.nih.gov/38608729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,37369882,Effects of Dietary Cystine and Tyrosine Supplementation on Melanin Synthesis in the Pacific Oyster (Crassostrea gigas).,2023,10.1007/s10126-023-10223-6,https://pubmed.ncbi.nlm.nih.gov/37369882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,40364322,Effects of Different Calcium Preparations on Fresh-Cut Quality and Storage Quality of Starkrimson Apple.,2025,10.3390/plants14091293,https://pubmed.ncbi.nlm.nih.gov/40364322/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,32161152,"Biallelic variants in MAATS1 encoding CFAP91, a calmodulin-associated and spoke-associated complex protein, cause severe astheno-teratozoospermia and male infertility.",2020,10.1136/jmedgenet-2019-106775,https://pubmed.ncbi.nlm.nih.gov/32161152/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,39834177,"Sulfur Dioxide Alleviates Aortic Dissection Through Inhibiting Vascular Smooth Muscle Cell Phenotype Switch, Migration, and Proliferation &lt;i&gt;via&lt;/i&gt; miR-184-3p/Cyp26b1 Axis.",2025,10.1089/ars.2023.0471,https://pubmed.ncbi.nlm.nih.gov/39834177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,39854304,Decoding the aroma of Rosa canina L.: Chemical composition and gene expression.,2025,10.1371/journal.pone.0316324,https://pubmed.ncbi.nlm.nih.gov/39854304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,36754175,Transcription factor CgPOU3F4-like regulates expression of pheomelanin synthesis related gene CgB-aat1 in the Pacific oyster (Crassostrea gigas).,2023,10.1016/j.gene.2023.147258,https://pubmed.ncbi.nlm.nih.gov/36754175/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,40284053,Integrated Analysis of the Metabolome and Transcriptome During Apple Ripening to Highlight Aroma Determinants in Ningqiu Apples.,2025,10.3390/plants14081165,https://pubmed.ncbi.nlm.nih.gov/40284053/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,37685316,Utility of the Serum Protein Electrophoresis in the Opportunistic Screening for the Deficiency of Alpha-1 Antitrypsin.,2023,10.3390/diagnostics13172778,https://pubmed.ncbi.nlm.nih.gov/37685316/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,37685383,Genotypic Frequencies of Mutations Associated with Alpha-1 Antitrypsin Deficiency in Unrelated Bone Marrow Donors from the Murcia Region Donor Registry in the Southeast of Spain.,2023,10.3390/diagnostics13172845,https://pubmed.ncbi.nlm.nih.gov/37685383/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,40072693,System metabolic engineering modification of Saccharomyces cerevisiae to increase SAM production.,2025,10.1186/s40643-025-00858-9,https://pubmed.ncbi.nlm.nih.gov/40072693/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,37642676,Expression of alcohol acyltransferase is a potential determinant of fruit volatile ester variations in Capsicum.,2023,10.1007/s00299-023-03064-z,https://pubmed.ncbi.nlm.nih.gov/37642676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,40247054,Disparate co-evolution and prevalence of sulfadoxine and pyrimethamine resistance alleles and haplotypes at dhfr and dhps genes across Africa.,2025,10.1038/s41598-025-98035-7,https://pubmed.ncbi.nlm.nih.gov/40247054/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,38953022,Sulfur dioxide inhibits mast cell degranulation by sulphenylation of galectin-9 at cysteine 74.,2024,10.3389/fimmu.2024.1369326,https://pubmed.ncbi.nlm.nih.gov/38953022/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,29410428,Heterologous Expression of a Novel Drug Transporter from the Malaria Parasite Alters Resistance to Quinoline Antimalarials.,2018,10.1038/s41598-018-20816-0,https://pubmed.ncbi.nlm.nih.gov/29410428/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,34529793,"Genetic diagnosis, sperm phenotype and ICSI outcome in case of severe asthenozoospermia with multiple morphological abnormalities of the flagellum.",2021,10.1093/humrep/deab200,https://pubmed.ncbi.nlm.nih.gov/34529793/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,32849341,Ustilago maydis Serves as a Novel Production Host for the Synthesis of Plant and Fungal Sesquiterpenoids.,2020,10.3389/fmicb.2020.01655,https://pubmed.ncbi.nlm.nih.gov/32849341/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,31446181,Expression Levels of 4 Genes in Colon Tissue Might Be Used to Predict Which Patients Will Enter Endoscopic Remission After Vedolizumab Therapy for Inflammatory Bowel Diseases.,2020,10.1016/j.cgh.2019.08.030,https://pubmed.ncbi.nlm.nih.gov/31446181/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,24373994,Dose-dependent effect of sulfur dioxide on brain damage induced by recurrent febrile seizures in rats.,2014,10.1016/j.neulet.2013.12.042,https://pubmed.ncbi.nlm.nih.gov/24373994/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP91,ENSG00000183833,Unsafe,15863901,Structure and characterization of AAT-1 isoforms.,2005,10.1248/bpb.28.898,https://pubmed.ncbi.nlm.nih.gov/15863901/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP92,ENSG00000114656,Unsafe,18579725,Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies.,2008,10.1677/joe-08-0027,https://pubmed.ncbi.nlm.nih.gov/18579725/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP96,ENSG00000205129,Unsafe,36741255,C4orf47 contributes to the dormancy of pancreatic cancer under hypoxic conditions.,2023,10.7150/jca.78993,https://pubmed.ncbi.nlm.nih.gov/36741255/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP96,ENSG00000205129,Unsafe,37097647,C4orf47 Contributes to the Induction of Stem-like Properties in Gallbladder Cancer Under Hypoxia.,2023,10.21873/anticanres.16352,https://pubmed.ncbi.nlm.nih.gov/37097647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP96,ENSG00000205129,Unsafe,25074808,Proteomic analysis of mammalian sperm cells identifies new components of the centrosome.,2014,10.1242/jcs.157008,https://pubmed.ncbi.nlm.nih.gov/25074808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP96,ENSG00000205129,Unsafe,15809229,Comparative gene finding in chicken indicates that we are closing in on the set of multi-exonic widely expressed human genes.,2005,10.1093/nar/gki328,https://pubmed.ncbi.nlm.nih.gov/15809229/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFAP99,ENSG00000206113,Unsafe,30289875,Identification of Key Genes and Pathways Associated with RUNX1 Mutations in Acute Myeloid Leukemia Using Bioinformatics Analysis.,2018,10.12659/msm.910916,https://pubmed.ncbi.nlm.nih.gov/30289875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,42440407,Association of FHR5 With Disease Severity in ANCA-Associated Vasculitis.,2026,10.1016/j.ekir.2026.106623,https://pubmed.ncbi.nlm.nih.gov/42440407/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,42217727,Complement-Mediated Postpartum Atypical Hemolytic Uremic Syndrome With Collapsing Focal Segmental Glomerulosclerosis Associated With a Novel CFHR5 Copy Number Variant.,2026,10.1053/j.ajkd.2026.03.044,https://pubmed.ncbi.nlm.nih.gov/42217727/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,42433799,CFHR5 promotes colorectal cancer by upregulating COX4I2 to inhibit ferroptosis.,2026,10.1097/ms9.0000000000004897,https://pubmed.ncbi.nlm.nih.gov/42433799/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,41810513,A novel fusion protein reduces kidney complement in experimental C3 glomerulopathy.,2026,10.1093/cei/uxag015,https://pubmed.ncbi.nlm.nih.gov/41810513/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,42780117,Multi-omics analyses demonstrate complement dysregulation is involved in focal segmental glomerulosclerosis.,2026,10.3389/fimmu.2026.1852918,https://pubmed.ncbi.nlm.nih.gov/42780117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,41626425,"The &lt;i&gt;CFH-CFHR5&lt;/i&gt; Locus in Wet Age-Related Macular Degeneration, Polypoidal Choroidal Vasculopathy, and Central Serous Chorioretinopathy.",2026,10.1016/j.xops.2025.101043,https://pubmed.ncbi.nlm.nih.gov/41626425/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,37955705,Complement dysregulation associated with a genetic variant in factor H-related protein 5 in atypical hemolytic uremic syndrome.,2024,10.1007/s00467-023-06184-6,https://pubmed.ncbi.nlm.nih.gov/37955705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,41990104,Systematic prioritization of potential therapeutic targets for glomerulonephritis using multi-omics Mendelian randomization.,2026,10.1371/journal.pcbi.1014174,https://pubmed.ncbi.nlm.nih.gov/41990104/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,41301692,Exosome-Based Proteomic Profiling for Biomarker Discovery in Pediatric Fabry Disease: Insights into Early Diagnosis Monitoring.,2025,10.3390/biomedicines13112598,https://pubmed.ncbi.nlm.nih.gov/41301692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,38981555,Immune and regulative characterization of complement-related gene cfhl5 in response to Vibrio harveyi challenge in Cynoglossus semilaevis.,2024,10.1016/j.fsi.2024.109755,https://pubmed.ncbi.nlm.nih.gov/38981555/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,40593839,Loss of CFHR5 function reduces the risk for age-related macular degeneration.,2025,10.1038/s41467-025-61193-3,https://pubmed.ncbi.nlm.nih.gov/40593839/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,40918143,Discovery and early validation of serum protein signatures in untreated multiple sclerosis patients: identification of candidate biomarkers for diagnosis and stratification.,2025,10.3389/fimmu.2025.1579045,https://pubmed.ncbi.nlm.nih.gov/40918143/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,38418621,The complement factor H-related protein-5 (CFHR5) exacerbates pathological bone formation in ankylosing spondylitis.,2024,10.1007/s00109-024-02428-6,https://pubmed.ncbi.nlm.nih.gov/38418621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,42396458,Complement mediated thrombotic microangiopathy after liver transplantation in combination with a novel C6 variant of uncertain significance.,2026,10.3389/fimmu.2026.1774160,https://pubmed.ncbi.nlm.nih.gov/42396458/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,40250423,Rare predicted loss-of-function and damaging missense variants in CFHR5 associate with protection from age-related macular degeneration.,2025,10.1016/j.ajhg.2025.03.016,https://pubmed.ncbi.nlm.nih.gov/40250423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,41473684,Rare Structural Variants Uncovered by Optical Genome Mapping in Multisystem Inflammatory Syndrome in Children (MIS-C).,2025,10.1002/ggn2.202500023,https://pubmed.ncbi.nlm.nih.gov/41473684/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,42290787,"Maternal heat abatement during gestation alters growth, immunity, thermotolerance, and hepatic gene expression in beef offspring during backgrounding.",2026,10.3389/fvets.2026.1849652,https://pubmed.ncbi.nlm.nih.gov/42290787/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,33753502,Gain-of-function factor H-related 5 protein impairs glomerular complement regulation resulting in kidney damage.,2021,10.1073/pnas.2022722118,https://pubmed.ncbi.nlm.nih.gov/33753502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,37286573,Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.,2023,10.1038/s41467-023-38383-y,https://pubmed.ncbi.nlm.nih.gov/37286573/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,42627589,Systemic and local dysregulation of the complement system in glioma: a comprehensive systematic review.,2026,10.1007/s12094-026-04552-w,https://pubmed.ncbi.nlm.nih.gov/42627589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,32928961,The solution structure of the complement deregulator FHR5 reveals a compact dimer and provides new insights into CFHR5 nephropathy.,2020,10.1074/jbc.ra120.015132,https://pubmed.ncbi.nlm.nih.gov/32928961/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,38785556,Genetic Susceptibility in Endothelial Injury Syndromes after Hematopoietic Cell Transplantation and Other Cellular Therapies: Climbing a Steep Hill.,2024,10.3390/cimb46050288,https://pubmed.ncbi.nlm.nih.gov/38785556/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,39252215,Causal association of immune effector proteins with sepsis: A Mendelian randomization study.,2024,10.1097/md.0000000000039494,https://pubmed.ncbi.nlm.nih.gov/39252215/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,41839678,Comprehensive gene profiling by Next-Generation sequencing in a cohort of Egyptian pediatric Atypical HUS.,2026,10.1016/j.jgeb.2025.100656,https://pubmed.ncbi.nlm.nih.gov/41839678/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,38344730,Systematic Review of the Link Between Oxford MEST-C Classification and Complement Activation in IgA Nephropathy.,2024,10.1016/j.ekir.2023.11.005,https://pubmed.ncbi.nlm.nih.gov/38344730/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,37953280,Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer.,2023,10.1186/s12575-023-00223-0,https://pubmed.ncbi.nlm.nih.gov/37953280/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,40717883,Transplant-Associated Thrombotic Microangiopathy After Autologous Hematopoietic Stem Cell Transplantation Treated With Eculizumab.,2025,10.7759/cureus.88785,https://pubmed.ncbi.nlm.nih.gov/40717883/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,38061333,Protein-centric omics analysis reveals circulating complements linked to non-viral liver diseases as potential therapeutic targets.,2024,10.3350/cmh.2023.0343,https://pubmed.ncbi.nlm.nih.gov/38061333/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,36330526,Levels of soluble complement regulators predict severity of COVID-19 symptoms.,2022,10.3389/fimmu.2022.1032331,https://pubmed.ncbi.nlm.nih.gov/36330526/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,38343496,Atypical Hemolytic Uremic Syndrome: A Nationwide Colombian Pediatric Series.,2024,10.1177/2333794x241231133,https://pubmed.ncbi.nlm.nih.gov/38343496/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,37975850,Whole Genome Sequencing Identifies Novel Common and Low-Frequency Variants Associated With Age-Related Macular Degeneration.,2023,10.1167/iovs.64.14.24,https://pubmed.ncbi.nlm.nih.gov/37975850/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CFHR5,ENSG00000134389,Unsafe,33564431,Poor allograft outcome in Indian patients with post-transplant C3 glomerulopathy.,2021,10.1093/ckj/sfz135,https://pubmed.ncbi.nlm.nih.gov/33564431/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB1,ENSG00000267631,Unsafe,32957442,The Study of the Expression of CGB1 and CGB2 in Human Cancer Tissues.,2020,10.3390/genes11091082,https://pubmed.ncbi.nlm.nih.gov/32957442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB1,ENSG00000267631,Unsafe,31362717,Regulation of human chorionic gonadotropin beta subunit expression in ovarian cancer.,2019,10.1186/s12885-019-5960-2,https://pubmed.ncbi.nlm.nih.gov/31362717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB1,ENSG00000267631,Unsafe,23774837,Human chorionic gonadotropin beta subunit genes CGB1 and CGB2 are transcriptionally active in ovarian cancer.,2013,10.3390/ijms140612650,https://pubmed.ncbi.nlm.nih.gov/23774837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB1,ENSG00000267631,Unsafe,18048458,Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues.,2008,10.1093/molehr/gam082,https://pubmed.ncbi.nlm.nih.gov/18048458/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB1,ENSG00000267631,Unsafe,24778026,Novel insights into the expression of CGB1 & 2 genes by epithelial cancer cell lines secreting ectopic free hCGβ.,2014,,https://pubmed.ncbi.nlm.nih.gov/24778026/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB1,ENSG00000267631,Unsafe,17055150,The evolution and genomic landscape of CGB1 and CGB2 genes.,2007,10.1016/j.mce.2005.11.049,https://pubmed.ncbi.nlm.nih.gov/17055150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB1,ENSG00000267631,Unsafe,15590838,"G-protein beta subunit of Cochliobolus heterostrophus involved in virulence, asexual and sexual reproductive ability, and morphogenesis.",2004,10.1128/ec.3.6.1653-1663.2004,https://pubmed.ncbi.nlm.nih.gov/15590838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB1,ENSG00000267631,Unsafe,16123088,Expression of beta-subunit of HCG genes during normal and failed pregnancy.,2005,10.1093/humrep/dei261,https://pubmed.ncbi.nlm.nih.gov/16123088/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB1,ENSG00000267631,Unsafe,25063728,Methylation status of human chorionic gonadotropin beta subunit promoter and TFAP2A expression as factors regulating CGB gene expression in placenta.,2014,10.1016/j.fertnstert.2014.06.016,https://pubmed.ncbi.nlm.nih.gov/25063728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB1,ENSG00000267631,Unsafe,11368883,Analysis of the human CGB/LHB gene cluster in breast tumors by real-time quantitative RT-PCR assays.,2001,10.1016/s0304-3835(01)00496-7,https://pubmed.ncbi.nlm.nih.gov/11368883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB1,ENSG00000267631,Unsafe,18606016,High divergence in primate-specific duplicated regions: human and chimpanzee chorionic gonadotropin beta genes.,2008,10.1186/1471-2148-8-195,https://pubmed.ncbi.nlm.nih.gov/18606016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB1,ENSG00000267631,Unsafe,15138309,Genome-wide linkage analysis of chromogranin B expression in the CEPH pedigrees: implications for exocytotic sympathochromaffin secretion in humans.,2004,10.1152/physiolgenomics.00104.2003,https://pubmed.ncbi.nlm.nih.gov/15138309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,41048937,Comprehensive pan-cancer analysis reveals CGB5 is a potential promising predictive and immunotherapeutic biomarker.,2025,10.3389/fmed.2025.1624815,https://pubmed.ncbi.nlm.nih.gov/41048937/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,40262449,Expression characteristics and biological functions of CGB5 gene in gastric cancer.,2025,10.1016/j.acthis.2025.152254,https://pubmed.ncbi.nlm.nih.gov/40262449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,41929453,Placental transcriptome profiling in congenital Chagas disease: gene networks associated with transmission.,2026,10.3389/fcimb.2026.1749307,https://pubmed.ncbi.nlm.nih.gov/41929453/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,41085794,A prognostic model for gastric cancer constructed by multiple machine learning algorithms.,2025,10.1007/s10735-025-10629-7,https://pubmed.ncbi.nlm.nih.gov/41085794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,39544937,Development and validation of preeclampsia predictive models using key genes from bioinformatics and machine learning approaches.,2024,10.3389/fimmu.2024.1416297,https://pubmed.ncbi.nlm.nih.gov/39544937/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,41667698,HLA-DPA1 as a diagnostic biomarker differentiating early- and late-onset preeclampsia.,2026,10.1038/s41598-026-39050-0,https://pubmed.ncbi.nlm.nih.gov/41667698/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,33565425,"Testicular germ cell tumors type 2 have high RNA expression of LDHB, the gene for lactate dehydrogenase subunit B.",2021,10.4103/aja.aja_4_21,https://pubmed.ncbi.nlm.nih.gov/33565425/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,40852501,Development of Non-HLA Antibodies and Their Association With Antibody-Mediated Rejection in Pediatric Kidney Transplant Recipients.,2025,10.3389/ti.2025.14463,https://pubmed.ncbi.nlm.nih.gov/40852501/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,32957442,The Study of the Expression of CGB1 and CGB2 in Human Cancer Tissues.,2020,10.3390/genes11091082,https://pubmed.ncbi.nlm.nih.gov/32957442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,41234821,Bulk and single-cell transcriptomics of stomach adenocarcinoma provide prognostic insights via the application of a novel gene signature associated with manganese metabolism.,2025,10.21037/tcr-2025-1826,https://pubmed.ncbi.nlm.nih.gov/41234821/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,35624327,"CGB5, INHBA and TRAJ19 Hold Prognostic Potential as Immune Genes for Patients with Gastric Cancer.",2023,10.1007/s10620-022-07513-9,https://pubmed.ncbi.nlm.nih.gov/35624327/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,38228846,Construction of an immune-related risk score signature for gastric cancer based on multi-omics data.,2024,10.1038/s41598-024-52087-3,https://pubmed.ncbi.nlm.nih.gov/38228846/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,34222004,"Novel Prognostic Biomarkers in Gastric Cancer: CGB5, MKNK2, and PAPPA2.",2021,10.3389/fonc.2021.683582,https://pubmed.ncbi.nlm.nih.gov/34222004/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,35796645,Identification of potential biomarkers and survival analysis for oral squamous cell carcinoma: A transcriptomic study.,2023,10.1111/odi.14302,https://pubmed.ncbi.nlm.nih.gov/35796645/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,37999824,Mapping the immunological battlefield in gastric cancer: prognostic implications of an immune gene expression signature.,2023,10.1007/s12672-023-00834-9,https://pubmed.ncbi.nlm.nih.gov/37999824/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,36456645,Development and validation of a novel immune-related prognostic signature in lung squamous cell carcinoma patients.,2022,10.1038/s41598-022-23140-w,https://pubmed.ncbi.nlm.nih.gov/36456645/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,40741267,A prognostic model for stomach adenocarcinoma based on hypoxia- and immune-related genes.,2025,10.5114/aoms/167481,https://pubmed.ncbi.nlm.nih.gov/40741267/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,35722389,Screening of prognostic immune genes and establishment of prognostic model of cervical adenocarcinoma based on bioinformatics analysis.,2022,10.21037/atm-22-1851,https://pubmed.ncbi.nlm.nih.gov/35722389/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,32767150,N- and O-glycosylation patterns and functional testing of CGB7 versus CGB3/5/8 variants of the human chorionic gonadotropin (hCG) beta subunit.,2020,10.1007/s10719-020-09936-w,https://pubmed.ncbi.nlm.nih.gov/32767150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,37780567,Development and validation of prognostic index based on purine metabolism genes in patients with bladder cancer.,2023,10.3389/fmed.2023.1193133,https://pubmed.ncbi.nlm.nih.gov/37780567/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,38577455,Construction of an immune-related gene signature for overall survival prediction and immune infiltration in gastric cancer.,2024,10.4251/wjgo.v16.i3.919,https://pubmed.ncbi.nlm.nih.gov/38577455/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,37377916,Glutamine metabolism genes prognostic signature for stomach adenocarcinoma and immune infiltration: potential biomarkers for predicting overall survival.,2023,10.3389/fonc.2023.1201297,https://pubmed.ncbi.nlm.nih.gov/37377916/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,37129813,Development and validation of a tobacco smoking-related index for predicting overall survival and immunotherapy response in bladder cancer.,2023,10.1007/s11356-023-27132-9,https://pubmed.ncbi.nlm.nih.gov/37129813/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,35627105,A Risk Model of Eight Immune-Related Genes Predicting Prognostic Response to Immune Therapies for Gastric Cancer.,2022,10.3390/genes13050720,https://pubmed.ncbi.nlm.nih.gov/35627105/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,35692814,Development of a Novel Immune-Related Gene Signature to Predict Prognosis and Immunotherapeutic Efficiency in Gastric Cancer.,2022,10.3389/fgene.2022.885553,https://pubmed.ncbi.nlm.nih.gov/35692814/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,36389725,A novel necroptosis-related gene index for predicting prognosis and a cold tumor immune microenvironment in stomach adenocarcinoma.,2022,10.3389/fimmu.2022.968165,https://pubmed.ncbi.nlm.nih.gov/36389725/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB5,ENSG00000189052,Unsafe,16123088,Expression of beta-subunit of HCG genes during normal and failed pregnancy.,2005,10.1093/humrep/dei261,https://pubmed.ncbi.nlm.nih.gov/16123088/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB8,ENSG00000213030,Unsafe,32957442,The Study of the Expression of CGB1 and CGB2 in Human Cancer Tissues.,2020,10.3390/genes11091082,https://pubmed.ncbi.nlm.nih.gov/32957442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB8,ENSG00000213030,Unsafe,41416139,[Inhibitory Effects of the Deep Underground Low Background Radiation Environment on the Proliferation and Migration of NP69 Human Nasopharyngeal Epithelial Cells and the Underlying Mechanisms].,2025,10.12182/20251160402,https://pubmed.ncbi.nlm.nih.gov/41416139/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB8,ENSG00000213030,Unsafe,32767150,N- and O-glycosylation patterns and functional testing of CGB7 versus CGB3/5/8 variants of the human chorionic gonadotropin (hCG) beta subunit.,2020,10.1007/s10719-020-09936-w,https://pubmed.ncbi.nlm.nih.gov/32767150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB8,ENSG00000213030,Unsafe,33220636,Development of a novel 7 immune-related genes prognostic model for oral cancer: A study based on TCGA database.,2021,10.1016/j.oraloncology.2020.105088,https://pubmed.ncbi.nlm.nih.gov/33220636/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB8,ENSG00000213030,Unsafe,22554618,Structural and functional analysis of rare missense mutations in human chorionic gonadotrophin β-subunit.,2012,10.1093/molehr/gas018,https://pubmed.ncbi.nlm.nih.gov/22554618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB8,ENSG00000213030,Unsafe,20962020,Methylation allelic polymorphism (MAP) in chorionic gonadotropin beta5 (CGB5) and its association with pregnancy success.,2011,10.1210/jc.2010-1647,https://pubmed.ncbi.nlm.nih.gov/20962020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB8,ENSG00000213030,Unsafe,23499152,A modest but significant effect of CGB5 gene promoter polymorphisms in modulating the risk of recurrent miscarriage.,2013,10.1016/j.fertnstert.2013.02.019,https://pubmed.ncbi.nlm.nih.gov/23499152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB8,ENSG00000213030,Unsafe,18048458,Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues.,2008,10.1093/molehr/gam082,https://pubmed.ncbi.nlm.nih.gov/18048458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB8,ENSG00000213030,Unsafe,18782867,Chorionic gonadotropin beta-gene variants are associated with recurrent miscarriage in two European populations.,2008,10.1210/jc.2008-1101,https://pubmed.ncbi.nlm.nih.gov/18782867/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB8,ENSG00000213030,Unsafe,11368883,Analysis of the human CGB/LHB gene cluster in breast tumors by real-time quantitative RT-PCR assays.,2001,10.1016/s0304-3835(01)00496-7,https://pubmed.ncbi.nlm.nih.gov/11368883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB8,ENSG00000213030,Unsafe,16123088,Expression of beta-subunit of HCG genes during normal and failed pregnancy.,2005,10.1093/humrep/dei261,https://pubmed.ncbi.nlm.nih.gov/16123088/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CGB8,ENSG00000213030,Unsafe,18606016,High divergence in primate-specific duplicated regions: human and chimpanzee chorionic gonadotropin beta genes.,2008,10.1186/1471-2148-8-195,https://pubmed.ncbi.nlm.nih.gov/18606016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42811518,Dual CHK1 and WNT Inhibition as a Synergistic Therapy for Gastrointestinal Neuroendocrine Carcinoma.,2026,10.1158/2767-9764.crc-26-0351,https://pubmed.ncbi.nlm.nih.gov/42811518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42083788,Molecular modulators of cyclin-dependent kinase 4/6 inhibitor response in experimental glioma identified through genome-wide CRISPR-Cas9 screening.,2026,10.1093/neuonc/noag093,https://pubmed.ncbi.nlm.nih.gov/42083788/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,41722056,Pancancer Fine-Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma.,2026,10.1002/advs.202521265,https://pubmed.ncbi.nlm.nih.gov/41722056/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42772808,Matrine Suppresses Lung Cancer Progression via Dual Inhibition of CHEK1-Mediated DNA Damage Repair and PI3K/AKT Survival Signaling.,2026,10.1111/1759-7714.70393,https://pubmed.ncbi.nlm.nih.gov/42772808/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42212602,Mutational and Expressional Deregulation of the &lt;i&gt;CHEK1&lt;/i&gt; Gene in Breast Cancer Patients.,2026,10.1080/07357907.2026.2661618,https://pubmed.ncbi.nlm.nih.gov/42212602/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42653731,Integrative Bioinformatics Identification of Baicalein as a Phytochemical Inhibitor of CHEK1 in Serous Ovarian Cancer: A Multi-Stage In Silico Drug Discovery Approach.,2026,10.3390/ph19081234,https://pubmed.ncbi.nlm.nih.gov/42653731/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,41564103,Multi-omics analysis and functional validation of CHEK1 as an independent prognostic biomarker in Pancreatic cancer.,2026,10.1371/journal.pone.0340878,https://pubmed.ncbi.nlm.nih.gov/41564103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42220437,CHK1 as a Metabolic and Immunological Regulator: Implications for Cancer Therapy.,2026,10.32604/or.2026.076509,https://pubmed.ncbi.nlm.nih.gov/42220437/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42449966,"Polyporusterone E, a Key Component of &lt;i&gt;Polyporus umbellatus&lt;/i&gt;, as a Potential Regulator of CHEK 1 in Liver Cancer: Integrated Network Pharmacology, Bioinformatics, and Experimental Validation.",2026,10.3390/ijms27135694,https://pubmed.ncbi.nlm.nih.gov/42449966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42229233,CHK1 activates mitophagy to attenuate cardiac aging via inhibiting AHSA1-ubiquitination.,2026,10.1016/j.redox.2026.104242,https://pubmed.ncbi.nlm.nih.gov/42229233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42303828,KPT-330-mediated XPO1 inhibition impairs homologous recombination and enhances radiosensitivity in extranodal NK/T-cell lymphoma.,2026,10.1038/s41416-026-03492-0,https://pubmed.ncbi.nlm.nih.gov/42303828/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42786371,"Integrative bioinformatics and machine learning reveal hub genes and immune signatures bridging type 2 diabetes mellitus, fracture susceptibility, and osteoblast differentiation dysfunction.",2026,10.1007/s00335-026-10276-7,https://pubmed.ncbi.nlm.nih.gov/42786371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,40548926,Integrative miRNOMe profiling reveals the miR-195-5p-CHEK1 axis and its impact on luminal breast cancer outcomes.,2025,10.1002/1878-0261.70077,https://pubmed.ncbi.nlm.nih.gov/40548926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42731029,TRRAP enables MMB-dependent mitotic transcription and determines sensitivity to CHK1 inhibition.,2026,10.1016/j.celrep.2026.117985,https://pubmed.ncbi.nlm.nih.gov/42731029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,41308413,Lysine demethylase 5D promotes CHEK1 inhibitor sensitivity through p38-mediated cyclooxygenase-2 expression in castration-resistant prostate cancer cells.,2025,10.1016/j.jpet.2025.103769,https://pubmed.ncbi.nlm.nih.gov/41308413/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42074514,Integrated Multi-Omics and Machine Learning Framework Identifies Diagnostic Signatures and Druggable Targets in Breast Cancer.,2026,10.3390/genes17040396,https://pubmed.ncbi.nlm.nih.gov/42074514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42882893,"Chk1/2 Inhibition by AZD7762 Enhances Andrographolide-Induced DNA Damage, Impairs DNA Repair, and Promotes Apoptosis in Head and Neck Squamous Cell Carcinoma CAL-33 Cells.",2026,10.3390/cancers18193199,https://pubmed.ncbi.nlm.nih.gov/42882893/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,41807370,Identification of isoform switching events linked with esophageal adenocarcinoma patient survival informs novel prognostic and therapeutic targets.,2026,10.1038/s41419-026-08542-2,https://pubmed.ncbi.nlm.nih.gov/41807370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42086533,Proteasomal-dependent CHK1 degradation leads to DNA damage accumulation in ALS cellular model systems.,2026,10.1038/s41419-026-08603-6,https://pubmed.ncbi.nlm.nih.gov/42086533/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42073491,Dynamics of Postmortem Gene Expression in Normal and Neoplastic Murine Liver.,2026,10.3390/life16040683,https://pubmed.ncbi.nlm.nih.gov/42073491/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42910276,CHK1 and CHK2 as Context-Dependent Rheostats of Genotoxic Stress: Implications for Cell Fate and Tumor Immunity.,2026,10.7150/ijbs.139580,https://pubmed.ncbi.nlm.nih.gov/42910276/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42339120,Radiogenomics and the DNA damage response: opportunities for biomarker-guided radiosensitization in pancreatic cancer.,2026,10.3389/fonc.2026.1762867,https://pubmed.ncbi.nlm.nih.gov/42339120/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,41402978,Research progress of DNA damage repair (DDR) and DDR inhibitors in tumor immunotherapy.,2025,10.1186/s12957-025-04101-9,https://pubmed.ncbi.nlm.nih.gov/41402978/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,41683580,Targeting ATR-CHK1 and ATM-CHK2 Axes in Pancreatic Cancer-A Comprehensive Review of Literature.,2026,10.3390/ijms27031152,https://pubmed.ncbi.nlm.nih.gov/41683580/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42407398,"Precision targeting in biliary tract cancer therapy: A geographical, target, and efficacy analysis of clinical trials.",2026,10.1016/j.bbcan.2026.189643,https://pubmed.ncbi.nlm.nih.gov/42407398/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,41799521,Next Generation DNA Damage Response Inhibitors: Harnessing Nanocarriers and Tumor Microenvironment for Precision Cancer Therapy.,2026,10.32604/or.2026.071632,https://pubmed.ncbi.nlm.nih.gov/41799521/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42451670,Overcoming Resistance in Triple-Negative Breast Cancer: A Translational Perspective on Next-Generation DNA Damage Response Inhibitors and Synthetic Lethality.,2026,10.3390/molecules31132303,https://pubmed.ncbi.nlm.nih.gov/42451670/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42853659,IGF2BP1 in 17q-gain cooperates with MYCN to regulate purine biosynthesis and immunotherapy efficacy in neuroblastoma.,2026,10.1073/pnas.2524540123,https://pubmed.ncbi.nlm.nih.gov/42853659/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42426296,Paediatric therapeutic development workshop on medulloblastoma.,2026,10.1038/s41416-026-03533-8,https://pubmed.ncbi.nlm.nih.gov/42426296/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42148103,PARylation-centric crosstalk: orchestrating immune evasion and multidrug resistance in ovarian cancer.,2026,10.3389/fimmu.2026.1772562,https://pubmed.ncbi.nlm.nih.gov/42148103/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42611560,CD73 inhibition overcomes adaptive immune resistance to PARP inhibition in models of prostate cancer.,2026,10.1172/jci203785,https://pubmed.ncbi.nlm.nih.gov/42611560/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,40422251,Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage.,2025,10.3390/cells14100748,https://pubmed.ncbi.nlm.nih.gov/40422251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42201394,Targeting KIF18B overcomes oxaliplatin resistance in esophageal squamous cell carcinoma via suppression of the ATR/CHK1 axis.,2026,10.1007/s00438-026-02440-0,https://pubmed.ncbi.nlm.nih.gov/42201394/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,42917904,Structure-Based Optimization of 2-Aminopyrimidine Derivatives as Potent Multi-target FLT3/CHK1/IRAK4 Inhibitors for Acute Myeloid Leukemia.,2026,10.1021/acs.jmedchem.6c01936,https://pubmed.ncbi.nlm.nih.gov/42917904/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,9382850,Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes.,1997,10.1016/s0960-9822(06)00417-9,https://pubmed.ncbi.nlm.nih.gov/9382850/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHEK1,ENSG00000149554,Unsafe,9278511,Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.,1997,10.1126/science.277.5331.1497,https://pubmed.ncbi.nlm.nih.gov/9278511/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,42717094,Neocortical long-range inhibition promotes cortical synchrony and sleep.,2026,10.1038/s41586-026-10876-y,https://pubmed.ncbi.nlm.nih.gov/42717094/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,42905535,Molecular signatures of selective motor neuron vulnerability in old age.,2026,10.1113/ep094279,https://pubmed.ncbi.nlm.nih.gov/42905535/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,42576008,Molecular alterations in chondrolectin-containing somatostatin neurons in schizophrenia differ based on circuit context.,2026,10.1038/s41380-026-03763-5,https://pubmed.ncbi.nlm.nih.gov/42576008/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,42088368,Chondrolectin regulates the sublaminar localization and regenerative function of muscle satellite cells in mice.,2026,10.1016/j.isci.2026.115703,https://pubmed.ncbi.nlm.nih.gov/42088368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,42378240,Somatic mutation profiles in aged military nuclear test veterans: A comparative whole-genome sequence study.,2026,10.1371/journal.pone.0351624,https://pubmed.ncbi.nlm.nih.gov/42378240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,40403704,Enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits.,2025,10.1016/j.neuron.2025.04.035,https://pubmed.ncbi.nlm.nih.gov/40403704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,42667220,Integrated Bulk and Single-Cell Transcriptomic Analyses Identify a Five-Gene Signature Associated With Prognosis and the Tumor Microenvironment in Epstein-Barr Virus-Associated Gastric Cancer.,2026,10.1155/genr/5991107,https://pubmed.ncbi.nlm.nih.gov/42667220/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,40385068,Single-cell RNA sequencing of adult primate neocortex reveals the regulatory dynamics of neural plasticity.,2025,10.62347/zeor5569,https://pubmed.ncbi.nlm.nih.gov/40385068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,40742160,Gut microbiota contribute to high-altitude adaptation in tree sparrows.,2025,10.1128/msystems.00630-25,https://pubmed.ncbi.nlm.nih.gov/40742160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,38975339,Integrating single-cell and spatial transcriptomic analysis to unveil heterogeneity in high-grade serous ovarian cancer.,2024,10.3389/fimmu.2024.1420847,https://pubmed.ncbi.nlm.nih.gov/38975339/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,41007969,Host Genetic Effects and Phenotypic Landscapes of Rumen Bacterial Enterotypes in a Large Sheep Population.,2025,10.3390/ani15182724,https://pubmed.ncbi.nlm.nih.gov/41007969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,38770169,Integration of Single-Cell RNA Sequencing and Bulk RNA Sequencing to Identify an Immunogenic Cell Death-Related 5-Gene Prognostic Signature in Hepatocellular Carcinoma.,2024,10.2147/jhc.s449419,https://pubmed.ncbi.nlm.nih.gov/38770169/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,35535889,Perspective on automated in vivo drug screening using the chodl mutant zebrafish line.,2022,10.4103/1673-5374.335795,https://pubmed.ncbi.nlm.nih.gov/35535889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,32226505,Promoter Hypermethylation of CHODL Contributes to Carcinogenesis and Indicates Poor Survival in Patients with Early-stage Colorectal Cancer.,2020,10.7150/jca.38815,https://pubmed.ncbi.nlm.nih.gov/32226505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,39909380,Topology-driven discovery of transmembrane protein S-palmitoylation.,2025,10.1016/j.jbc.2025.108259,https://pubmed.ncbi.nlm.nih.gov/39909380/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,33973627,Automated in vivo drug screen in zebrafish identifies synapse-stabilising drugs with relevance to spinal muscular atrophy.,2021,10.1242/dmm.047761,https://pubmed.ncbi.nlm.nih.gov/33973627/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,28356950,Expression of CHODL in hepatocellular carcinoma affects invasion and migration of liver cancer cells.,2017,10.3892/ol.2016.5466,https://pubmed.ncbi.nlm.nih.gov/28356950/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,31665626,Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation.,2019,10.1016/j.celrep.2019.09.033,https://pubmed.ncbi.nlm.nih.gov/31665626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,36581816,m6A RNA methylation regulator-based signature for prognostic prediction and its potential immunological role in uterine corpus endometrial carcinoma.,2022,10.1186/s12885-022-10490-x,https://pubmed.ncbi.nlm.nih.gov/36581816/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,29765130,Copy number variants implicate cardiac function and development pathways in earthquake-induced stress cardiomyopathy.,2018,10.1038/s41598-018-25827-5,https://pubmed.ncbi.nlm.nih.gov/29765130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,18161010,The cytoplasmic domain of chondrolectin interacts with the beta-subunit of Rab geranylgeranyl transferase.,2008,10.2478/s11658-007-0052-8,https://pubmed.ncbi.nlm.nih.gov/18161010/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,17606388,"Expression and localization of CHODLDeltaE/CHODLfDeltaE, the soluble isoform of chondrolectin.",2007,10.1016/j.cellbi.2007.05.014,https://pubmed.ncbi.nlm.nih.gov/17606388/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,12621022,A novel alternative spliced chondrolectin isoform lacking the transmembrane domain is expressed during T cell maturation.,2003,10.1074/jbc.m300653200,https://pubmed.ncbi.nlm.nih.gov/12621022/,annotation citations | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,12079284,"Molecular cloning and characterization of human chondrolectin, a novel type I transmembrane protein homologous to C-type lectins.",2002,10.1006/geno.2002.6806,https://pubmed.ncbi.nlm.nih.gov/12079284/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHODL,ENSG00000154645,Unsafe,11707072,From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map.,2001,10.1006/geno.2001.6640,https://pubmed.ncbi.nlm.nih.gov/11707072/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,42778344,Butyrylcholinesterase alleviates hepatic stellate cell activation via paracrine muscarinic signalling.,2026,10.1136/gutjnl-2026-338932,https://pubmed.ncbi.nlm.nih.gov/42778344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,42497870,A self-amplifying nerve-fibroblast circuit drives colorectal cancer progression.,2026,10.1016/j.ccell.2026.06.018,https://pubmed.ncbi.nlm.nih.gov/42497870/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,41516199,Influence of the Cholinergic System on the Pathogenesis of Glioblastoma: Impact of the Neutrophil Granulocytes.,2025,10.3390/ijms27010321,https://pubmed.ncbi.nlm.nih.gov/41516199/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,41857244,Transcriptional and functional profiles of muscarinic receptor-expressing neurons in primate lateral prefrontal and anterior cingulate cortices.,2026,10.1038/s42003-026-09866-7,https://pubmed.ncbi.nlm.nih.gov/41857244/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,42700788,Deduhonghua-7 powder and its bioactive component luteolin alleviate hepatic fibrosis through CHRM3/NF-κB axis.,2026,10.1016/j.yexcr.2026.115169,https://pubmed.ncbi.nlm.nih.gov/42700788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,41870649,FTO-CHRM3 axis regulates multiple myeloma progression: a machine learning-based identification.,2026,10.1007/s00277-026-06940-2,https://pubmed.ncbi.nlm.nih.gov/41870649/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,41452458,Selective modulation of murine intestinal M&lt;sub&gt;1&lt;/sub&gt; and M&lt;sub&gt;3&lt;/sub&gt; muscarinic receptor expression has divergent effects on specialized epithelial cells and body weight.,2026,10.1152/ajpcell.00739.2025,https://pubmed.ncbi.nlm.nih.gov/41452458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,42057406,Polygonatum sibiricum Alleviates Salivary Gland Dysfunction in Sjögren's Syndrome via CHRM3/AQP5 Axis Potentiation.,2026,10.1055/a-2867-4341,https://pubmed.ncbi.nlm.nih.gov/42057406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,42688638,From human dental pulp stem cells to functional cholinergic neurons: An optimized neurogenic differentiation protocol for new approach methodologies.,2026,10.1016/j.jds.2025.10.025,https://pubmed.ncbi.nlm.nih.gov/42688638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,42795812,Integrating Pharmacodynamic Data to Prioritise Candidate Migraine Genes and Pathways Using a Novel Bioinformatics Workflow.,2026,10.3390/jcm15187040,https://pubmed.ncbi.nlm.nih.gov/42795812/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,40858831,Aberrant PJA2-CHRM3 signaling creates a therapeutic vulnerability in gastric tumor.,2025,10.1038/s41416-025-03145-8,https://pubmed.ncbi.nlm.nih.gov/40858831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,42418103,"The malignant synapse: architecture, signal integration, and therapeutic vulnerabilities in glioma.",2026,10.1007/s13402-026-01252-z,https://pubmed.ncbi.nlm.nih.gov/42418103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,40691854,Differential effects of antiemetic serotonin receptor antagonist Ondansetron on nausea associated with CHRM3 rs2165870 and TACR1 rs3755468 single-nucleotide polymorphisms.,2025,10.1186/s13041-025-01237-3,https://pubmed.ncbi.nlm.nih.gov/40691854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,40718823,"AMPs inhibit the proliferation, migration, and invasion of lung cancer via the CHRM3/PI3K/AKT and CHRM3/MAPK pathways.",2025,10.3389/fonc.2025.1582040,https://pubmed.ncbi.nlm.nih.gov/40718823/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,42577419,Integrative machine learning and single-cell analysis identifies nicotine-related diagnostic genes and myeloid remodeling in COPD.,2026,10.3389/fimmu.2026.1880745,https://pubmed.ncbi.nlm.nih.gov/42577419/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,42220436,Neurotransmitter-Mediated Signaling in Glioblastoma and Glial Tumors: Biology and Therapeutic Opportunities.,2026,10.32604/or.2026.076088,https://pubmed.ncbi.nlm.nih.gov/42220436/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,42769221,Delayed late ventricular depolarization is associated with inflammation in epicardial Fat Among females: a New avenue in cardiac electrophysiology.,2026,10.3389/fcvm.2026.1947506,https://pubmed.ncbi.nlm.nih.gov/42769221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,40624113,GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation.,2025,10.1038/s41598-025-10576-z,https://pubmed.ncbi.nlm.nih.gov/40624113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,41655016,ALKBH5 orchestrates ferroptosis-driven tumor suppression: An LLM-powered discovery in prostate cancer.,2026,10.1016/j.ymthe.2026.02.003,https://pubmed.ncbi.nlm.nih.gov/41655016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,39885271,Muscarinic acetylcholine receptor 3 localized to primary endothelial cilia regulates blood pressure and cognition.,2025,10.1038/s41598-025-87212-3,https://pubmed.ncbi.nlm.nih.gov/39885271/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,41644789,Identification of key bioactive compounds of medicine-food homologous substances and their multi-target intervention effects in ulcerative colitis treatment.,2026,10.1007/s00210-026-05057-7,https://pubmed.ncbi.nlm.nih.gov/41644789/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,41734179,Association of G-Protein-Coupled Receptors autoantibodies with vasoregulation in Post-COVID.,2026,10.1371/journal.pone.0343264,https://pubmed.ncbi.nlm.nih.gov/41734179/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,41301871,"Toxicological Impacts and Mechanistic Insights of Bisphenol a on Clear Cell Renal Cell Carcinoma Progression: A Network Toxicology, Machine Learning and Molecular Docking Study.",2025,10.3390/biomedicines13112778,https://pubmed.ncbi.nlm.nih.gov/41301871/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,41686584,Potential mechanisms of Si-Wu-Tang against esophageal squamous cell carcinoma: A machine learning pharmacological study.,2026,10.1097/md.0000000000047629,https://pubmed.ncbi.nlm.nih.gov/41686584/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,39355254,Identification of telomere-related lncRNAs and immunological analysis in ovarian cancer.,2024,10.3389/fimmu.2024.1452946,https://pubmed.ncbi.nlm.nih.gov/39355254/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,39081703,Tongxieyaofang Decotion Alleviates IBS by Modulating CHRM3 and Gut Barrier.,2024,10.2147/dddt.s455497,https://pubmed.ncbi.nlm.nih.gov/39081703/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,39163289,CHRM3 (rs2165870) gene polymorphism is related to postoperative vomiting in female patients undergoing laparoscopic surgery. Prospective observational study.,2024,10.1371/journal.pone.0309136,https://pubmed.ncbi.nlm.nih.gov/39163289/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,38203175,Targeting Farnesoid X Receptor in Tumor and the Tumor Microenvironment: Implication for Therapy.,2023,10.3390/ijms25010006,https://pubmed.ncbi.nlm.nih.gov/38203175/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,40253162,"Comprehensive review on human Milk oligosaccharides: Biosynthesis, structure, intestinal health benefits, immune regulation, neuromodulation mechanisms, and applications.",2025,10.1016/j.foodres.2025.116328,https://pubmed.ncbi.nlm.nih.gov/40253162/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,39917251,Association of the dopamine D2 receptor gene SNP rs1800497 with postoperative nausea and vomiting: A prospective cohort study.,2024,10.1097/ea9.0000000000000056,https://pubmed.ncbi.nlm.nih.gov/39917251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,41254172,Impact of pesticide diazinon on gastric cancer cell lines and the alteration of cholinergic and serotonergic pathway genes affecting cell proliferation.,2025,10.1038/s41598-025-24414-9,https://pubmed.ncbi.nlm.nih.gov/41254172/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,38010846,"Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults.",2024,10.1111/jch.14753,https://pubmed.ncbi.nlm.nih.gov/38010846/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRM3,ENSG00000133019,Unsafe,39821165,Brain-wide neuronal circuit connectome of human glioblastoma.,2025,10.1038/s41586-025-08634-7,https://pubmed.ncbi.nlm.nih.gov/39821165/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,42304190,Smoking exposure alters splicing of the nicotinic acetylcholine receptor subunit CHRNA5.,2026,10.1186/s40246-026-01004-y,https://pubmed.ncbi.nlm.nih.gov/42304190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,41675052,Disruption of &lt;i&gt;chrna5&lt;/i&gt; blunts aversion and adaptive transcriptomic responses to nicotine and alcohol.,2026,10.1016/j.isci.2026.114735,https://pubmed.ncbi.nlm.nih.gov/41675052/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,42422064,"The CHRNA5 rs16969968 variant is associated with MMP-9 expression and inflammatory signaling in COPD in a West Bengal population, India.",2026,10.3389/fphar.2026.1841945,https://pubmed.ncbi.nlm.nih.gov/42422064/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,42382379,Focal Polycomb-Mediated Repression of Neuronal Identity and Synaptic Maintenance Genes in Aging Neurons.,2026,10.7759/cureus.111824,https://pubmed.ncbi.nlm.nih.gov/42382379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,42547009,CHRNA5 orchestrates tumorigenesis and immune invasion through the CaMKII/AKT/NF-κB-CCL20 axis in pancreatic ductal adenocarcinoma.,2026,10.1016/j.lfs.2026.124610,https://pubmed.ncbi.nlm.nih.gov/42547009/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,42329050,Association between CHRNA5 polymorphisms and Parkinson's disease in Northern Chinese Han population: a case-control study.,2026,10.1080/03014460.2026.2682270,https://pubmed.ncbi.nlm.nih.gov/42329050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,41201200,"The Biological and Prognostic Implications of the Nicotinic Acetylcholine Receptor α3, α5, and α7 Subunits in Oral Squamous Cell Carcinoma.",2025,10.1002/cam4.71358,https://pubmed.ncbi.nlm.nih.gov/41201200/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,40336011,Retroelement co-option disrupts the cancer transcriptional programme.,2025,10.1186/s13073-025-01479-9,https://pubmed.ncbi.nlm.nih.gov/40336011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,41527136,Multiple trait association analysis revealed common genetic loci between lung cancer and heart failure.,2026,10.1186/s40959-025-00438-y,https://pubmed.ncbi.nlm.nih.gov/41527136/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,41192616,The α5-nAChR/GINS4 axis contributed to nicotine-promoted lung adenocarcinoma progression.,2026,10.1016/j.fct.2025.115828,https://pubmed.ncbi.nlm.nih.gov/41192616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,42277644,"TP53-META, a meta-analysis tool for comparative transcriptomics of TP53 dependency: examples from target silencing and liver fibrosis.",2026,10.1186/s12859-026-06465-5,https://pubmed.ncbi.nlm.nih.gov/42277644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,40755048,Identification of rs2036527 as a cis-regulatory variant for CHRNA3 and CHRNA5 by allele-specific expression and implications for nicotine dependence and lung cancer.,2026,10.1111/ajad.70074,https://pubmed.ncbi.nlm.nih.gov/40755048/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,42345644,Dual E-Cigarette Users Show Nicotine Addiction Risk Alleles and Nuclear Abnormalities in Oral Epithelial Cells.,2026,10.3390/arm94030039,https://pubmed.ncbi.nlm.nih.gov/42345644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,39472448,"Nicotine-induced CHRNA5 activation modulates CES1 expression, impacting head and neck squamous cell carcinoma recurrence and metastasis via MEK/ERK pathway.",2024,10.1038/s41419-024-07178-4,https://pubmed.ncbi.nlm.nih.gov/39472448/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,41007821,Exploring the Associations Between &lt;i&gt;CHRNA5&lt;/i&gt; and &lt;i&gt;IREB2&lt;/i&gt; Gene Polymorphisms and COPD in the Kazakhstan Population.,2025,10.3390/biomedicines13092260,https://pubmed.ncbi.nlm.nih.gov/41007821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,41808243,The clinical usefulness of knowing &lt;i&gt;CHRNA5&lt;/i&gt; polymorphism genotype: paving the way for personalized therapy.,2026,10.1177/03008916251408279,https://pubmed.ncbi.nlm.nih.gov/41808243/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,42805833,"[Nicotinic receptor polymorphism amplifies cigarette smoke-induced inflammation in COPD, a silent epidemic].",2026,10.1016/j.rmr.2026.07.008,https://pubmed.ncbi.nlm.nih.gov/42805833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,39686588,Novel Transgenic Zebrafish Lines to Study the CHRNA3-B4-A5 Gene Cluster.,2025,10.1002/dneu.22956,https://pubmed.ncbi.nlm.nih.gov/39686588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,41309559,The influence of CHRNA5 and D398N missense variation on social and emotional behaviors in rodents and humans.,2025,10.1038/s41398-025-03725-5,https://pubmed.ncbi.nlm.nih.gov/41309559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,41482775,CHRNA5 D398N mutation in addiction: Pathogenic insights and therapeutic discovery.,2026,10.36721/pjps.2026.39.1.reg.14072.1,https://pubmed.ncbi.nlm.nih.gov/41482775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,41579494,Genetic risk factors for pneumonia differ by patient subgroup.,2026,10.1016/j.ebiom.2026.106136,https://pubmed.ncbi.nlm.nih.gov/41579494/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,40143965,Perspectives on the α5 nicotinic acetylcholine receptor in lung cancer progression.,2025,10.3389/fcell.2025.1489958,https://pubmed.ncbi.nlm.nih.gov/40143965/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,39505853,Distinct Chrna5 mutations link excessive alcohol use to types I/II vulnerability profiles and IPN GABAergic neurons.,2024,10.1038/s41398-024-03164-8,https://pubmed.ncbi.nlm.nih.gov/39505853/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,38840910,Identifying and assessing a prognostic model based on disulfidptosis-related genes: implications for immune microenvironment and tumor biology in lung adenocarcinoma.,2024,10.3389/fimmu.2024.1371831,https://pubmed.ncbi.nlm.nih.gov/38840910/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,38331937,CHRNA5 links chandelier cells to severity of amyloid pathology in aging and Alzheimer's disease.,2024,10.1038/s41398-024-02785-3,https://pubmed.ncbi.nlm.nih.gov/38331937/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,38862938,"Investigating CHRNA5, CHRNA3, and CHRNB4 variants in the genetic landscape of substance use disorder in Jordan.",2024,10.1186/s12888-024-05898-7,https://pubmed.ncbi.nlm.nih.gov/38862938/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,39208422,Smoking-Related Increases in Alcohol Outcomes and Preliminary Evidence for the Protective Effect of a Functional Nicotine Receptor Gene (CHRNA5) Variant on Alcohol Consumption in Individuals Without Alcohol Use Disorder.,2024,10.1093/ijnp/pyae035,https://pubmed.ncbi.nlm.nih.gov/39208422/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,38409471,Machine learning reveals diverse cell death patterns in lung adenocarcinoma prognosis and therapy.,2024,10.1038/s41698-024-00538-5,https://pubmed.ncbi.nlm.nih.gov/38409471/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,41203580,Smoking-Induced STC2+ Tumor Cells Drive Tumor-Vascular Crosstalk in Laryngeal Squamous Cell Carcinoma via Spatial and Single-Cell Transcriptomics.,2026,10.1002/advs.202511932,https://pubmed.ncbi.nlm.nih.gov/41203580/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,40993956,"PGx-Based &lt;i&gt;in silico&lt;/i&gt; Analyses Identifies the Interactive Role of Genes, Glucose Metabolism and Dopaminergic Dysfunctional Pathways with Chronic Cocaine use and Misuse.",2026,10.2174/011570159x390146250831143523,https://pubmed.ncbi.nlm.nih.gov/40993956/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,40376268,Unveiling the heritability of selected unexplored pharmacogenetic markers in the Saudi population.,2025,10.3389/fphar.2025.1559399,https://pubmed.ncbi.nlm.nih.gov/40376268/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,40082977,Association between autoimmune disease and neurodevelopmental disorder: a Mendelian randomization analysis.,2025,10.1186/s13052-025-01910-2,https://pubmed.ncbi.nlm.nih.gov/40082977/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,40799911,Role of ferroptosis-related IREB2 in the shared genetic etiology between smoking and facial aging: Insights from large-scale genome-wide cross-trait analysis.,2025,10.1016/j.csbj.2025.07.049,https://pubmed.ncbi.nlm.nih.gov/40799911/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA5,ENSG00000169684,Unsafe,40530147,Development and validation of prognostic models based on cell cycle-related signatures for predicting the prognosis of patients with lung adenocarcinoma.,2025,10.21037/tcr-24-1479,https://pubmed.ncbi.nlm.nih.gov/40530147/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,42292701,"Pan-cancer expression, methylation, and prognostic significance of α7 nicotinic acetylcholine receptor in tumor immunology.",2026,10.1016/j.bbrep.2026.102649,https://pubmed.ncbi.nlm.nih.gov/42292701/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,42708368,Activation of lung megakaryocyte α7 nAChR exacerbates allergic airway inflammation via IL-33/p38 MAPK signaling.,2026,10.1172/jci.insight.202201,https://pubmed.ncbi.nlm.nih.gov/42708368/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,42247028,"Neurobehavioral Impacts of the Autism Risk Gene, WAC: Studies Involving C. elegans and Mice.",2026,10.1007/s12035-026-05964-z,https://pubmed.ncbi.nlm.nih.gov/42247028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,42155866,The absence of the alpha-7 nicotinic acetylcholine receptor impairs liver regeneration due to altered autophagic response after resection.,2026,10.1016/j.aohep.2026.102234,https://pubmed.ncbi.nlm.nih.gov/42155866/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,41201200,"The Biological and Prognostic Implications of the Nicotinic Acetylcholine Receptor α3, α5, and α7 Subunits in Oral Squamous Cell Carcinoma.",2025,10.1002/cam4.71358,https://pubmed.ncbi.nlm.nih.gov/41201200/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,42640585,Increased markers of heavy metal exposure and DNA methylation in cluster headache.,2026,10.1177/03331024261480707,https://pubmed.ncbi.nlm.nih.gov/42640585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,42288732,Proteomic profiling reveals structural and adhesion pathways regulated by the inverted CHRFAM7AΔ2bp variant in human neural progenitor cells.,2026,10.1186/s12868-026-01016-3,https://pubmed.ncbi.nlm.nih.gov/42288732/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,40847805,Activation of the alpha 7 nicotinic acetylcholine receptor (CHRNA7) limits hypoxia-induced inflammatory responses and regulates collagens in cultured human granulosa cells†.,2026,10.1093/biolre/ioaf196,https://pubmed.ncbi.nlm.nih.gov/40847805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,42769145,Adult-onset hippocampal α7 nicotinic acetylcholine receptor loss rapidly drives Alzheimer-like neuropathology in mice.,2026,10.3389/fphar.2026.1929468,https://pubmed.ncbi.nlm.nih.gov/42769145/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,40792169,Nicotine-induced PD-L1 expression in lung squamous cell carcinoma is mediated by the α7-nAChR/STAT3 signaling pathway.,2025,10.21037/tcr-2024-2587,https://pubmed.ncbi.nlm.nih.gov/40792169/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,42267150,Wrist-Ankle Acupuncture Alleviates Paclitaxel-Induced Neuropathic Pain in Mice by Neuronal α7 Nicotinic Acetylcholine Receptor-Dependent Modulation of Spinal Glutamatergic/NMDAR Signaling.,2026,10.2147/jpr.s604818,https://pubmed.ncbi.nlm.nih.gov/42267150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,42896815,Prenatal Maternal Phosphatidylcholine and Children's Behavior and Cognition through 4 Years of Age: Randomized Clinical Trial.,2026,10.1016/j.ajog.2026.10.017,https://pubmed.ncbi.nlm.nih.gov/42896815/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,40911568,The molecular components of the anti-inflammatory cholinergic pathway are extrasplenic.,2025,10.1371/journal.pone.0331707,https://pubmed.ncbi.nlm.nih.gov/40911568/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,42012794,Nicotinic Acetylcholine Receptor of α7 Subtype is Linked to Glioblastoma Cholinergic Heterogeneity.,2026,10.1007/s12031-026-02523-y,https://pubmed.ncbi.nlm.nih.gov/42012794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,40593693,α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex.,2025,10.1038/s41467-025-61167-5,https://pubmed.ncbi.nlm.nih.gov/40593693/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,37432973,An ovarian phenotype of alpha 7 nicotinic receptor knockout mice.,2023,10.1530/rep-23-0123,https://pubmed.ncbi.nlm.nih.gov/37432973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,42738550,Integrating Physiology and Multi-Omics Reveals Mechanisms Underlying Sperm Activation and Movement in Mandarin Fish (&lt;i&gt;Siniperca chuatsi&lt;/i&gt;).,2026,10.3390/ani16172762,https://pubmed.ncbi.nlm.nih.gov/42738550/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,42068762,"Neurobehavioral and molecular responses of the endemic barbel Carasobarbus fritschii to pyriproxyfen, salinity, and thermal stress.",2026,10.1016/j.aquatox.2026.107834,https://pubmed.ncbi.nlm.nih.gov/42068762/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,41125665,Transcriptomic analysis identifies a potential target for bevacizumab resistant glioblastoma.,2025,10.1038/s41598-025-20847-4,https://pubmed.ncbi.nlm.nih.gov/41125665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,42229868,A critical role for α7 nicotinic acetylcholine receptor signaling in myeloid lineage cells in chronic neuropathic and inflammatory pain responses.,2026,10.1016/j.jpain.2026.106339,https://pubmed.ncbi.nlm.nih.gov/42229868/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,40653990,Genetic and pharmacological targeting of nicotinic acetylcholine receptor action blocks tumor progression in mouse models of breast cancer.,2025,10.1093/jimmun/vkaf148,https://pubmed.ncbi.nlm.nih.gov/40653990/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,41663888,Signal-Level Determinants of Cognitive Decline With PPIs versus H&lt;sub&gt;2&lt;/sub&gt;RAs: Transportome (CBLIF/TCN2) and CHRNA7 Nodes.,2026,10.1002/mnfr.70382,https://pubmed.ncbi.nlm.nih.gov/41663888/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,41928597,Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Central Memory Th Cells in an α7 Nicotinic Acetylcholine Receptor-Dependent Manner.,2026,10.1002/eji.70177,https://pubmed.ncbi.nlm.nih.gov/41928597/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,40705171,PS77: a novel peptide with α-helical structure for targeted anti-inflammatory therapy in biomaterials design.,2025,10.1007/s12026-025-09663-0,https://pubmed.ncbi.nlm.nih.gov/40705171/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,37569633,GTS-21 Enhances Regulatory T Cell Development from T Cell Receptor-Activated Human CD4&lt;sup&gt;+&lt;/sup&gt; T Cells Exhibiting Varied Levels of &lt;i&gt;CHRNA7&lt;/i&gt; and &lt;i&gt;CHRFAM7A&lt;/i&gt; Expression.,2023,10.3390/ijms241512257,https://pubmed.ncbi.nlm.nih.gov/37569633/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,40593127,Exploring the mechanism of Naringenin in the treatment of hepatocellular carcinoma based on mRNA sequencing and experimental validation.,2025,10.1038/s41598-025-09013-y,https://pubmed.ncbi.nlm.nih.gov/40593127/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,36831101,Effects of Different Exercise Types on Chrna7 and Chrfam7a Expression in Healthy Normal Weight and Overweight Type 2 Diabetic Adults.,2023,10.3390/biomedicines11020565,https://pubmed.ncbi.nlm.nih.gov/36831101/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,41068898,The role of genetic polymorphisms on drug response in Alzheimer's disease: a systematic review.,2025,10.1186/s12920-025-02225-1,https://pubmed.ncbi.nlm.nih.gov/41068898/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,40880366,Computational model of alpha 7 nicotinic acetylcholine receptor in thalamic reticular nucleus neurons and their involvement in network states.,2025,10.1371/journal.pone.0330635,https://pubmed.ncbi.nlm.nih.gov/40880366/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,12508119,Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation.,2003,10.1038/nature01339,https://pubmed.ncbi.nlm.nih.gov/12508119/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNA7,ENSG00000175344,Unsafe,8145738,Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes.,1994,10.1016/s0026-895x(25)10029-1,https://pubmed.ncbi.nlm.nih.gov/8145738/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,42382379,Focal Polycomb-Mediated Repression of Neuronal Identity and Synaptic Maintenance Genes in Aging Neurons.,2026,10.7759/cureus.111824,https://pubmed.ncbi.nlm.nih.gov/42382379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,42073514,CHRNB4-Mediated Neuroactive Signaling Rewiring Drives Adaptive Resistance to BCL-2 Inhibition in Acute Myeloid Leukemia.,2026,10.3390/cancers18081187,https://pubmed.ncbi.nlm.nih.gov/42073514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,40534703,The impact of bilberry extract combined with docosahexaenoic acid on the expression of Chrnb4 gene in the sclera of myopic guinea pigs.,2025,10.3389/fmed.2025.1590362,https://pubmed.ncbi.nlm.nih.gov/40534703/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,39686588,Novel Transgenic Zebrafish Lines to Study the CHRNA3-B4-A5 Gene Cluster.,2025,10.1002/dneu.22956,https://pubmed.ncbi.nlm.nih.gov/39686588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,40197297,"Association of SNPs in nAChRs genes, areca nut chewing and smoking, and their interaction with lung cancer in Hainan, China: a case control study.",2025,10.1186/s12885-025-14020-3,https://pubmed.ncbi.nlm.nih.gov/40197297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,42454935,Integrated multi-omics analysis reveals gut microbiota-associated placental metabolic and transcriptomic alterations in placenta previa.,2026,10.1128/msystems.00687-26,https://pubmed.ncbi.nlm.nih.gov/42454935/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,38862938,"Investigating CHRNA5, CHRNA3, and CHRNB4 variants in the genetic landscape of substance use disorder in Jordan.",2024,10.1186/s12888-024-05898-7,https://pubmed.ncbi.nlm.nih.gov/38862938/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,39505077,Effect of high mobility group box 1 pathway inhibition on gene expression in the prefrontal cortex of mice exposed to alcohol.,2025,10.1016/j.alcohol.2024.10.047,https://pubmed.ncbi.nlm.nih.gov/39505077/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,39980243,"Normal bronchial field basal cells show persistent methylome-wide impact of tobacco smoking, including in known cancer genes.",2025,10.1080/15592294.2025.2466382,https://pubmed.ncbi.nlm.nih.gov/39980243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,40772705,Adiphenine Alleviates Impulsive-Like Behaviors in Aged Mice by Inhibiting Nicotinic Acetylcholine Receptors.,2025,10.1111/jnc.70190,https://pubmed.ncbi.nlm.nih.gov/40772705/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,40164859,Nicotinic acetylcholine receptors regulate growth hormone in pituitary somatotrophs of tigers.,2025,10.1038/s42003-025-07980-6,https://pubmed.ncbi.nlm.nih.gov/40164859/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,39329756,Cannabinol (CBN) Influences the Ion Channels and Synaptic-Related Genes in NSC-34 Cell Line: A Transcriptomic Study.,2024,10.3390/cells13181573,https://pubmed.ncbi.nlm.nih.gov/39329756/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,39673390,"CHRNA5-A3-B4, CYP2A6, and DBH Genetic Associations With Smoking Cessation Throughout Adulthood Within Two Longitudinal Studies of Women.",2025,10.1093/ntr/ntae284,https://pubmed.ncbi.nlm.nih.gov/39673390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,36424418,The mu opioid receptor and the orphan receptor GPR151 contribute to social reward in the habenula.,2022,10.1038/s41598-022-24395-z,https://pubmed.ncbi.nlm.nih.gov/36424418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,37404751,Bioinformatic-based genetic characterizations of neural regulation in skin cutaneous melanoma.,2023,10.3389/fonc.2023.1166373,https://pubmed.ncbi.nlm.nih.gov/37404751/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,34912722,Identification of the Nerve-Cancer Cross-Talk-Related Prognostic Gene Model in Head and Neck Squamous Cell Carcinoma.,2021,10.3389/fonc.2021.788671,https://pubmed.ncbi.nlm.nih.gov/34912722/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,39938415,Repurposing of dipeptidyl peptidase FDA-approved drugs in Alzheimer's disease using network pharmacology and in-silico approaches.,2025,10.1016/j.compbiolchem.2025.108378,https://pubmed.ncbi.nlm.nih.gov/39938415/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,33304845,Identification of CHRNB4 as a Diagnostic/Prognostic Indicator and Therapeutic Target in Human Esophageal Squamous Cell Carcinoma.,2020,10.3389/fonc.2020.571167,https://pubmed.ncbi.nlm.nih.gov/33304845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,34381521,Application of Bioinformatics Methods to Identify Key Genes and Functions in Chronic Pelvic Pain.,2021,10.1155/2021/7257405,https://pubmed.ncbi.nlm.nih.gov/34381521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,32455963,An Integrated Genomic Strategy to Identify CHRNB4 as a Diagnostic/Prognostic Biomarker for Targeted Therapy in Head and Neck Cancer.,2020,10.3390/cancers12051324,https://pubmed.ncbi.nlm.nih.gov/32455963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,30882151,Variants in the CHRNA5-CHRNA3-CHRNB4 Region of Chromosome 15 Predict Gastrointestinal Adverse Events in the Transdisciplinary Tobacco Use Research Center Smoking Cessation Trial.,2020,10.1093/ntr/ntz044,https://pubmed.ncbi.nlm.nih.gov/30882151/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,35595472,Divergent Roles of α5 and β4 Nicotinic Receptor Subunits in Food Reward and Nicotine-induced Weight Loss in Male Mice.,2022,10.1210/endocr/bqac079,https://pubmed.ncbi.nlm.nih.gov/35595472/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,36794842,CHRNA5-A3-B4 and DRD2 Genes and Smoking Cessation Throughout Adulthood: A Longitudinal Study of Women.,2023,10.1093/ntr/ntad026,https://pubmed.ncbi.nlm.nih.gov/36794842/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,31326446,"Toxicogenomic analyses of the effects of BDE-47/209, TBBPA/S and TCBPA on early neural development with a human embryonic stem cell in vitro differentiation system.",2019,10.1016/j.taap.2019.114685,https://pubmed.ncbi.nlm.nih.gov/31326446/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,32184221,β4-Nicotinic Receptors Are Critically Involved in Reward-Related Behaviors and Self-Regulation of Nicotine Reinforcement.,2020,10.1523/jneurosci.0356-19.2020,https://pubmed.ncbi.nlm.nih.gov/32184221/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,25214750,Genomics and personalized medicine: CHRNA5-CHRNA3-CHRNB4 and smoking cessation treatment.,2013,10.1016/j.jfda.2013.09.041,https://pubmed.ncbi.nlm.nih.gov/25214750/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,27871728,The CHRNA5-A3-B4 Gene Cluster and Smoking: From Discovery to Therapeutics.,2016,10.1016/j.tins.2016.10.005,https://pubmed.ncbi.nlm.nih.gov/27871728/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,32192034,Microbiota Alters Urinary Bladder Weight and Gene Expression.,2020,10.3390/microorganisms8030421,https://pubmed.ncbi.nlm.nih.gov/32192034/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,30354342,Druggability of Coronary Artery Disease Risk Loci.,2018,10.1161/circgen.117.001977,https://pubmed.ncbi.nlm.nih.gov/30354342/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,22648373,Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success.,2012,10.1176/appi.ajp.2012.11101545,https://pubmed.ncbi.nlm.nih.gov/22648373/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,25572450,Response to Transdermal Selegiline Smoking Cessation Therapy and Markers in the 15q24 Chromosomal Region.,2015,10.1093/ntr/ntu273,https://pubmed.ncbi.nlm.nih.gov/25572450/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,29971594,Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners.,2018,10.1007/s00420-018-1334-3,https://pubmed.ncbi.nlm.nih.gov/29971594/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,25072098,Beyond cigarettes per day. A genome-wide association study of the biomarker carbon monoxide.,2014,10.1513/annalsats.201401-010oc,https://pubmed.ncbi.nlm.nih.gov/25072098/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHRNB4,ENSG00000117971,Unsafe,29228394,"The Psychiatric Risk Gene Transcription Factor 4 (TCF4) Regulates Neurodevelopmental Pathways Associated With Schizophrenia, Autism, and Intellectual Disability.",2018,10.1093/schbul/sbx164,https://pubmed.ncbi.nlm.nih.gov/29228394/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,41177418,Single-cell sequencing analysis reveals CHURC1 as a non-canonical oncoprotein governing goblet cell-driven colorectal tumorigenesis.,2026,10.1016/j.cellsig.2025.112197,https://pubmed.ncbi.nlm.nih.gov/41177418/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,42247321,Neoplastic CD3⁺ B cells remodel the DLBCL tumor microenvironment via single-cell and spatial transcriptomics.,2026,10.1080/15384047.2026.2684140,https://pubmed.ncbi.nlm.nih.gov/42247321/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,42664297,Oxaloacetate damages mitochondria by perturbing MIC60-dependent membrane remodeling.,2026,10.1371/journal.pbio.3003649,https://pubmed.ncbi.nlm.nih.gov/42664297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,41171174,Denitrogenative Carbon Skeleton Cleavage and Reorganization of Pyridines by a Trinuclear Titanium Polyhydride Complex.,2025,10.1021/jacs.5c11238,https://pubmed.ncbi.nlm.nih.gov/41171174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,40329942,Lengthening of the CHURC1 3' untranslated region by alternative polyadenylation is associated with the progression of acute myeloid leukemia.,2025,10.1016/j.gendis.2024.101248,https://pubmed.ncbi.nlm.nih.gov/40329942/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,41496579,Age-Associated Dysregulation of Postsynaptic Mitochondria Perturbs Reinnervation Kinetics.,2026,10.1111/acel.70355,https://pubmed.ncbi.nlm.nih.gov/41496579/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,36358727,A Novel apaQTL-SNP for the Modification of Non-Small-Cell Lung Cancer Susceptibility across Histological Subtypes.,2022,10.3390/cancers14215309,https://pubmed.ncbi.nlm.nih.gov/36358727/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,42417408,Identifying selection signatures associated with production traits in Matou goats using whole-genome sequencing.,2026,10.1093/jas/skag202,https://pubmed.ncbi.nlm.nih.gov/42417408/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,37796022,ATP synthase-associated coiled-coil-helix-coiled-coil-helix (CHCH) domain-containing proteins are critical for mitochondrial function in &lt;i&gt;Toxoplasma gondii&lt;/i&gt;.,2023,10.1128/mbio.01769-23,https://pubmed.ncbi.nlm.nih.gov/37796022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,39645544,"Atmospheric reaction of CH2=CHCH2OCF2CHF2 with OH radicals and Cl atoms, UV and IR absorption cross sections, and global warming potential.",2024,10.1007/s11356-024-35536-4,https://pubmed.ncbi.nlm.nih.gov/39645544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,37589018,Locust protein hydrolysates have the potential to enhance the storage stability of cheese.,2023,10.1016/j.crfs.2023.100561,https://pubmed.ncbi.nlm.nih.gov/37589018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,39642579,"Potential COX-2 inhibitors modulating NF-κB/MAPK signaling pathways: Design, synthesis and evaluation of anti-inflammatory activity of Pterostilbene-carboxylic acid derivatives with an oxime ether moiety.",2025,10.1016/j.bmc.2024.118022,https://pubmed.ncbi.nlm.nih.gov/39642579/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,40537939,Polar Lithium l-Aspartate Monohydrate: A Semiorganic Ultraviolet Transparent Nonlinear Optical Crystal.,2025,10.1021/acs.inorgchem.5c02129,https://pubmed.ncbi.nlm.nih.gov/40537939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,38151566,Protein N-myristoylation plays a critical role in the mitochondrial localization of human mitochondrial complex I accessory subunit NDUFB7.,2023,10.1038/s41598-023-50390-z,https://pubmed.ncbi.nlm.nih.gov/38151566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,38672293,Genome-Wide Association Study of Body Conformation Traits in Tashi Goats (Capra hircus).,2024,10.3390/ani14081145,https://pubmed.ncbi.nlm.nih.gov/38672293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,30791515,"Twin CHCH Proteins, CHCHD2, and CHCHD10: Key Molecules of Parkinson's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia.",2019,10.3390/ijms20040908,https://pubmed.ncbi.nlm.nih.gov/30791515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,35173147,CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response.,2022,10.1038/s41419-022-04602-5,https://pubmed.ncbi.nlm.nih.gov/35173147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,36044574,Structural insights into crista junction formation by the Mic60-Mic19 complex.,2022,10.1126/sciadv.abo4946,https://pubmed.ncbi.nlm.nih.gov/36044574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,29789341,A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS.,2018,10.15252/emmm.201708558,https://pubmed.ncbi.nlm.nih.gov/29789341/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,35043806,"DFT and microkinetic study of acetylene transformation on Pd(111), M(111) and PdM(111) surfaces (M = Cu, Ag, Au).",2022,10.1039/d1cp05353a,https://pubmed.ncbi.nlm.nih.gov/35043806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,42493778,Mol2Image: an enhanced DDI prediction framework leveraging drug molecular descriptors.,2026,10.1186/s12859-026-06552-7,https://pubmed.ncbi.nlm.nih.gov/42493778/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,42467148,Multi-GraphDDI: Multi-Feature Fusion and Interaction for Graph-Based Drug-Drug Interaction Prediction.,2026,10.1007/s12539-026-00859-y,https://pubmed.ncbi.nlm.nih.gov/42467148/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,42361506,MCFusion-DDI: Multimodal cross-attention fusion of local-global features and latent drug associations for explainable DDI prediction.,2026,10.1016/j.neunet.2026.109278,https://pubmed.ncbi.nlm.nih.gov/42361506/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,41762455,In silico design and evaluation of hybrid antimicrobial peptides for combating environmental multidrug-resistant bacteria.,2026,10.1016/j.jhazmat.2026.141524,https://pubmed.ncbi.nlm.nih.gov/41762455/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,41178284,Reactivity of Low Valent Magnesium(I) Complexes with Epoxides and Episulfides.,2025,10.1002/anie.202520259,https://pubmed.ncbi.nlm.nih.gov/41178284/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,39860199,Hydrogen-Bonded Di(hydroperoxy)alkane Adducts of the Type Cy3P=O·(HOO)2CHR (R = Alkyl).,2025,10.3390/molecules30020329,https://pubmed.ncbi.nlm.nih.gov/39860199/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,39333180,"Formation of acetonitrile (CH3CN) under cold interstellar, tropospheric and combustion mediums.",2024,10.1038/s41598-024-70721-y,https://pubmed.ncbi.nlm.nih.gov/39333180/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,38400355,Spatial-Temporal Dynamic Evolution of Land Deformation Driven by Hydrological Signals around Chaohu Lake.,2024,10.3390/s24041198,https://pubmed.ncbi.nlm.nih.gov/38400355/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,32378051,Clinical evaluation of germline polymorphisms associated with capecitabine toxicity in breast cancer: TBCRC-015.,2020,10.1007/s10549-020-05603-8,https://pubmed.ncbi.nlm.nih.gov/32378051/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,24794912,Vardenafil dihydrochloride.,2014,10.1016/b978-0-12-800173-8.00009-x,https://pubmed.ncbi.nlm.nih.gov/24794912/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CHURC1,ENSG00000258289,Unsafe,25476776,CHCHD2 inhibits apoptosis by interacting with Bcl-x L to regulate Bax activation.,2015,10.1038/cdd.2014.194,https://pubmed.ncbi.nlm.nih.gov/25476776/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,42828966,FOXM1-mediated transcriptional activation of CILP2 promotes malignant phenotypes and EMT-associated remodeling in clear cell renal cell carcinoma.,2026,10.1016/j.prp.2026.156702,https://pubmed.ncbi.nlm.nih.gov/42828966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,41594707,"CILP2: From ECM Component to a Pleiotropic Modulator in Metabolic Dysfunction, Cancer, and Beyond.",2026,10.3390/biom16010167,https://pubmed.ncbi.nlm.nih.gov/41594707/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,42265151,Integrative transcriptomic and machine learning analysis identifies key extracellular matrix-related genes in diabetic retinopathy.,2026,10.1038/s41598-026-57016-0,https://pubmed.ncbi.nlm.nih.gov/42265151/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,41683641,Cartilage Intermediate Layer Protein 2 Aggravates Hepatic Lipid Accumulation and Inflammation Through the IRE1α/XBP1 Pathway.,2026,10.3390/ijms27031213,https://pubmed.ncbi.nlm.nih.gov/41683641/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,42248126,CILP2 exacerbates diabetes-induced muscle atrophy by over-activating skeletal muscle autophagy and inflammation via the P38 MAPK pathway.,2026,10.1016/j.intimp.2026.116967,https://pubmed.ncbi.nlm.nih.gov/42248126/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,41244802,Identification and validation of novel risk genes for intervertebral disc disorder by integrating large-scale multi-omics analyses and experimental studies.,2025,10.3389/fmed.2025.1698050,https://pubmed.ncbi.nlm.nih.gov/41244802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,40996951,Exploration of potential novel drug targets for rheumatoid arthritis by plasma proteome screening.,2025,10.1371/journal.pcbi.1013333,https://pubmed.ncbi.nlm.nih.gov/40996951/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,41514217,Urinary proteomic profiling reveals diagnostic biomarkers and regulatory networks in myasthenia gravis.,2026,10.1186/s12883-025-04623-5,https://pubmed.ncbi.nlm.nih.gov/41514217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,40837039,Cerium Oxide Nanoparticles Achieve Long-Lasting Senescence Inhibition in an Aging Mouse Model of Sarcopenia via Reactive Oxygen Species Scavenging and CILP2 Downregulation.,2025,10.1002/smsc.202500208,https://pubmed.ncbi.nlm.nih.gov/40837039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,39385717,Inhibition of CILP2 Improves Glucose Metabolism and Mitochondrial Dysfunction in Sarcopenia via the Wnt Signalling Pathway.,2024,10.1002/jcsm.13597,https://pubmed.ncbi.nlm.nih.gov/39385717/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,40108892,Metabolomics- and Proteomics-Based Disease Diagnostic Classifier Model for the Prediction and Diagnosis of Colorectal Carcinoma.,2025,10.1021/acs.jproteome.5c00010,https://pubmed.ncbi.nlm.nih.gov/40108892/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,38136386,The Prognostic and Immune Significance of CILP2 in Pan-Cancer and Its Relationship with the Progression of Pancreatic Cancer.,2023,10.3390/cancers15245842,https://pubmed.ncbi.nlm.nih.gov/38136386/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,41924874,Proteogenomic Analysis of Coronary Artery Calcification in Human Populations.,2026,10.1161/atvbaha.125.324171,https://pubmed.ncbi.nlm.nih.gov/41924874/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,38670440,CILP2 promotes hypertrophic scar through Snail acetylation by interaction with ACLY.,2024,10.1016/j.bbadis.2024.167202,https://pubmed.ncbi.nlm.nih.gov/38670440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,42022532,Osteopontin-expressing valvular interstitial cell subpopulation as a driver of extracellular matrix remodeling in aortic valve disease.,2026,10.3389/fcvm.2026.1755830,https://pubmed.ncbi.nlm.nih.gov/42022532/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,37144183,CILP2: A prognostic biomarker associated with immune infiltration in colorectal cancer.,2023,10.1016/j.heliyon.2023.e15535,https://pubmed.ncbi.nlm.nih.gov/37144183/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,35757483,Serum Concentrations of Cartilage Intermediate Layer Protein 2 Were Higher in Overweight and Obese Subjects.,2022,10.1155/2022/6290064,https://pubmed.ncbi.nlm.nih.gov/35757483/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,38816545,CILP2 is a potential biomarker for the prediction and therapeutic target of peritoneal metastases in colorectal cancer.,2024,10.1038/s41598-024-63366-4,https://pubmed.ncbi.nlm.nih.gov/38816545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,33204392,Circulating Levels of CILP2 Are Elevated in Coronary Heart Disease and Associated with Atherosclerosis.,2020,10.1155/2020/1871984,https://pubmed.ncbi.nlm.nih.gov/33204392/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,40841581,Early lipid genetics: identification of common and rare genetic variants for lipid traits in Indian adolescents.,2025,10.1038/s10038-025-01388-0,https://pubmed.ncbi.nlm.nih.gov/40841581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,38782984,Proteome-wide Mendelian randomization identifies potential therapeutic targets for nonalcoholic fatty liver diseases.,2024,10.1038/s41598-024-62742-4,https://pubmed.ncbi.nlm.nih.gov/38782984/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,37337170,A novel extrachromosomal circular DNA related genes signature for overall survival prediction in patients with ovarian cancer.,2023,10.1186/s12920-023-01576-x,https://pubmed.ncbi.nlm.nih.gov/37337170/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,29084944,DNA-Methylation and Body Composition in Preschool Children: Epigenome-Wide-Analysis in the European Childhood Obesity Project (CHOP)-Study.,2017,10.1038/s41598-017-13099-4,https://pubmed.ncbi.nlm.nih.gov/29084944/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,30311632,Genetic determinants of childhood and adult height associated with osteosarcoma risk.,2018,10.1002/cncr.31645,https://pubmed.ncbi.nlm.nih.gov/30311632/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,23119086,Variants identified in a GWAS meta-analysis for blood lipids are associated with the lipid response to fenofibrate.,2012,10.1371/journal.pone.0048663,https://pubmed.ncbi.nlm.nih.gov/23119086/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,18193044,"Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.",2008,10.1038/ng.75,https://pubmed.ncbi.nlm.nih.gov/18193044/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,21860704,Implications of discoveries from genome-wide association studies in current cardiovascular practice.,2011,10.4330/wjc.v3.i7.230,https://pubmed.ncbi.nlm.nih.gov/21860704/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,22325160,Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.,2012,10.1016/j.ajhg.2011.12.022,https://pubmed.ncbi.nlm.nih.gov/22325160/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,21880736,Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis.,2011,10.1074/jbc.m111.248039,https://pubmed.ncbi.nlm.nih.gov/21880736/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CILP2,ENSG00000160161,Unsafe,12746903,One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist.,2003,10.1002/art.10927,https://pubmed.ncbi.nlm.nih.gov/12746903/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1D,ENSG00000181781,Unsafe,42021739,Endothelial NOX1 Drives Obesity via Skeletal Muscle Mitochondrial Dysfunction.,2026,10.1161/circresaha.125.326768,https://pubmed.ncbi.nlm.nih.gov/42021739/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMAP1D,ENSG00000181781,Unsafe,33752626,Establishment of a typing model for diffuse large B-cell lymphoma based on B-cell receptor repertoire sequencing.,2021,10.1186/s12885-021-08015-z,https://pubmed.ncbi.nlm.nih.gov/33752626/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,42510602,&lt;i&gt;Capsicum annuum&lt;/i&gt; Regulates Tumor Growth Through Modulation of TLR4/PI3K Signaling in a Lewis Lung Carcinoma Mouse Model.,2026,10.3390/antiox15070871,https://pubmed.ncbi.nlm.nih.gov/42510602/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,41737220,Divergent CD45&lt;sup&gt;+&lt;/sup&gt; immune landscapes shape the lung tumor microenvironment.,2026,10.3389/fimmu.2026.1765833,https://pubmed.ncbi.nlm.nih.gov/41737220/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,41688207,"[LLC1 neoantigen dendritic cell vaccination combined with CpG effectively converts ""cold"" tumors into ""hot"" tumors in murine lung cancer].",2026,10.3760/cma.j.cn112152-20250611-00268,https://pubmed.ncbi.nlm.nih.gov/41688207/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,42586608,PGE2-mediated NK cell reprogramming drives acquired immunotherapy resistance in lung adenocarcinoma.,2026,10.1136/jitc-2025-014673,https://pubmed.ncbi.nlm.nih.gov/42586608/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,42368864,Vaccination against tumour endothelial marker Robo4 inhibits tumour growth.,2026,10.1093/immadv/ltag005,https://pubmed.ncbi.nlm.nih.gov/42368864/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,42381966,Systematic discovery of immunomodulatory plant-derived nanoparticles reveals RNA-mediated macrophage reprogramming.,2026,10.1016/j.bioactmat.2026.06.034,https://pubmed.ncbi.nlm.nih.gov/42381966/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,40852277,The Effect of &lt;i&gt;Cordyceps sinensis&lt;/i&gt; Polysaccharide Combined with Cisplatin on LLC1 Lung Cancer.,2025,10.1021/acsomega.4c11098,https://pubmed.ncbi.nlm.nih.gov/40852277/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,42205537,Tumor-directed evolution of VSVΔ51M produces novel viruses with enhanced antitumor efficacy.,2026,10.3389/fmolb.2026.1656006,https://pubmed.ncbi.nlm.nih.gov/42205537/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,42392203,Phytochemicals to Pharmacology: Potential Cytotoxic and Tumor Inhibitory Activity of Elaeocarpus ganitrus Extract in Preclinical Models.,2026,10.1055/a-2899-3112,https://pubmed.ncbi.nlm.nih.gov/42392203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,42653363,Preclinical Evaluation of Combined Polo-like Kinase 1 Inhibition and Navitoclax in Experimental Models of Lung Cancer.,2026,10.3390/ijms27167359,https://pubmed.ncbi.nlm.nih.gov/42653363/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,41443414,Catechol-linker and receptor-mediated site-specific delivery of bortezomib against non-small cell lung cancer.,2026,10.1016/j.jbc.2025.111095,https://pubmed.ncbi.nlm.nih.gov/41443414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,39708324,Protocol for generating brain metastatic tumor cells through repeated intracardiac injections in mice.,2025,10.1016/j.xpro.2024.103531,https://pubmed.ncbi.nlm.nih.gov/39708324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,42839610,Tumor-derived DLK1 restrains tumor progression through remodeling of the tumor immune microenvironment.,2026,,https://pubmed.ncbi.nlm.nih.gov/42839610/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,42120180,CXCL16-driven CD4&lt;sup&gt;+&lt;/sup&gt; T cells orchestrate immunosurveillance against MHC-I-deficient hepatocellular tumors.,2026,10.1136/jitc-2025-012347,https://pubmed.ncbi.nlm.nih.gov/42120180/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,40248740,Circulating lung cancer exosomes damage the niche of intestinal stem cells.,2025,10.21037/tlcr-24-758,https://pubmed.ncbi.nlm.nih.gov/40248740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,41292488,The novel thioredoxin reductase inhibitor butaselen suppresses lung cancer by inducing oxidative stress.,2025,10.1080/13510002.2025.2588086,https://pubmed.ncbi.nlm.nih.gov/41292488/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,39522095,Cyproheptadine inhibits in vitro and in vivo lung metastasis and drives metabolic rewiring.,2024,10.1007/s11033-024-10033-6,https://pubmed.ncbi.nlm.nih.gov/39522095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,39726814,"Retraction: Effects of gallotannin-enriched extract of Galla Rhois on the activation of apoptosis, cell cycle arrest, and inhibition of migration ability in LLC1 cells and LLC1 tumors.",2024,10.3389/pore.2024.1612042,https://pubmed.ncbi.nlm.nih.gov/39726814/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,41084279,Reprogrammed MDSCs promote Th1-dominant antitumour response via CD40 induced by autocrine TNF-α after combining cryo-thermal therapy with IL6 and IL17A neutralization.,2025,10.1002/ctm2.70493,https://pubmed.ncbi.nlm.nih.gov/41084279/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,38319449,CD36 inhibition reduces non-small-cell lung cancer development through AKT-mTOR pathway.,2024,10.1007/s10565-024-09848-7,https://pubmed.ncbi.nlm.nih.gov/38319449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,42254817,Synergistic Effect of Linebacker-1 With Radiation Therapy in a Mouse Lung Cancer Model.,2026,10.1016/j.adro.2026.102051,https://pubmed.ncbi.nlm.nih.gov/42254817/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,42258951,An immunogenomic classification of solid tumours reveals subtype-specific therapeutic vulnerabilities for immunotherapy.,2026,10.1016/j.ebiom.2026.106323,https://pubmed.ncbi.nlm.nih.gov/42258951/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,41181138,Pterostilbene inhibits non-small cell lung cancer progression by activating the STING pathway and enhancing antitumor immune response.,2025,10.3389/fimmu.2025.1622284,https://pubmed.ncbi.nlm.nih.gov/41181138/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,40064915,Comprehensive immunophenotyping reveals distinct tumor microenvironment alterations in anti-PD-1 sensitive and resistant syngeneic mouse model.,2025,10.1038/s41598-025-91979-w,https://pubmed.ncbi.nlm.nih.gov/40064915/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,42476286,Multifunctional nano-vaccines integrating lipid-conjugated tumor antigens with TLR/STING agonists enhance cancer immunotherapy.,2026,10.1016/j.canlet.2026.218736,https://pubmed.ncbi.nlm.nih.gov/42476286/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,40347254,The combination of SH003 and DTX induces cytotoxic cell infiltration in anti-PD1 resistant lung cancer.,2025,10.1007/s00262-025-04064-6,https://pubmed.ncbi.nlm.nih.gov/40347254/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,41887391,Targeting P2RY2 reprograms tumor immunity and inhibits tumor growth in non-small cell lung cancer.,2026,10.1016/j.canlet.2026.218448,https://pubmed.ncbi.nlm.nih.gov/41887391/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,38254898,Combinational Pulsing of TAAs Enforces Dendritic Cell-Based Immunotherapy through T-Cell Proliferation and Interferon-γ Secretion in LLC1 Mouse Model.,2024,10.3390/cancers16020409,https://pubmed.ncbi.nlm.nih.gov/38254898/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP1,ENSG00000124237,Unsafe,25786037,Immunohistochemical localization of LLC1 in human tissues and its limited expression in non-small cell lung cancer.,2015,10.14670/hh-11-608,https://pubmed.ncbi.nlm.nih.gov/25786037/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP2C,ENSG00000173557,Unsafe,36191189,SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.,2022,10.1073/pnas.2207605119,https://pubmed.ncbi.nlm.nih.gov/36191189/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIMIP6,ENSG00000177994,Unsafe,37565732,Integrated analysis of single-cell sequencing and weighted co-expression network identifies a novel signature based on cellular senescence-related genes to predict prognosis in glioblastoma.,2024,10.1002/tox.23921,https://pubmed.ncbi.nlm.nih.gov/37565732/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,41155727,The Emerging Role of the Cancerous Inhibitor of Protein Phosphatase 2A in Pulmonary Diseases.,2025,10.3390/medicina61101740,https://pubmed.ncbi.nlm.nih.gov/41155727/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,41961104,The hidden players: LncRNA-Encoded micropeptides in cancer hallmarks.,2026,10.1007/s00018-026-06151-y,https://pubmed.ncbi.nlm.nih.gov/41961104/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,41362702,"Ring Finger Protein 1, a Novel Ubiquitin E3 Ligase Targeting Cancerous Inhibitor of Protein Phosphatase 2A to Suppress Smoking-Induced Lung Tumorigenesis.",2025,10.1002/mco2.70522,https://pubmed.ncbi.nlm.nih.gov/41362702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,42636811,DDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development.,2026,10.1016/j.cell.2026.07.041,https://pubmed.ncbi.nlm.nih.gov/42636811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,40594400,Emerging roles of the cancerous inhibitor of protein phosphatase 2A (CIP2A) in ovarian cancer.,2025,10.1038/s41598-025-05013-0,https://pubmed.ncbi.nlm.nih.gov/40594400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,41898246,Resveratrol Mimics Exercise-Induced Metabolic Stress to Suppress CIP2A and Epithelial-Mesenchymal Transition in 3D Renal Carcinoma Spheroids.,2026,10.3390/biomedicines14030599,https://pubmed.ncbi.nlm.nih.gov/41898246/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,41977180,A Novel CIP2A and BCL-XL Clinical Diagnostic Toolkit to Predict Disease Progression and Treatment-Free Remission in Chronic Myeloid Leukaemia.,2026,10.3390/ijms27072991,https://pubmed.ncbi.nlm.nih.gov/41977180/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,42192029,CIP2A recruits SLX4-MUS81-XPF in mitosis and protects against replication stress.,2026,10.1038/s44319-026-00807-3,https://pubmed.ncbi.nlm.nih.gov/42192029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,42057038,Biomimetic PD-1 macrophage nanoplatform for Cip2a silencing and immune activation in oral squamous cell carcinoma.,2026,10.1186/s12951-026-04469-0,https://pubmed.ncbi.nlm.nih.gov/42057038/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,40943297,"The Prognostic Value of CIP2A and Its Association with CD31, E-Cadherin, and pAMPK in Lung Cancer.",2025,10.3390/ijms26178362,https://pubmed.ncbi.nlm.nih.gov/40943297/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,41724425,Endogenous inhibitors of PP2A activate oncogenic and DNA damage response kinases in glioblastoma.,2026,10.1016/j.canlet.2026.218325,https://pubmed.ncbi.nlm.nih.gov/41724425/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,41814766,[Sculponeatin A inhibits growth and induces apoptosis of triple-negative breast cancer cells by targeting c-Myc/CIP2A axis].,2026,10.19540/j.cnki.cjcmm.20251011.702,https://pubmed.ncbi.nlm.nih.gov/41814766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,40017141,CIP2A promotes bronchiolitis obliterans by activating the NF‑κB pathway.,2025,10.3892/mmr.2025.13473,https://pubmed.ncbi.nlm.nih.gov/40017141/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,41155583,UCHL1 Promotes Gastric Cancer Progression by Regulating CIP2A Degradation.,2025,10.3390/ph18101468,https://pubmed.ncbi.nlm.nih.gov/41155583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,40490703,CIP2A promotes inflammation and exacerbates osteoarthritis by targeting CEMIP.,2025,10.1186/s11658-025-00748-0,https://pubmed.ncbi.nlm.nih.gov/40490703/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,41330930,CIP2A mediates mitotic recruitment of SLX4/MUS81/XPF to resolve replication stress-induced DNA lesions.,2025,10.1038/s41467-025-66549-3,https://pubmed.ncbi.nlm.nih.gov/41330930/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,41309571,The CIP2A-TOPBP1 axis facilitates mitotic DNA repair via MiDAS and MMEJ.,2025,10.1038/s41467-025-65594-2,https://pubmed.ncbi.nlm.nih.gov/41309571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,42500572,ANLN: A New Hub in Glutamine Metabolism of Lung Adenocarcinoma by scRNA-Seq and Machine Learning.,2026,10.32604/or.2026.079515,https://pubmed.ncbi.nlm.nih.gov/42500572/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,42555732,Development of a structurally distinct TopBP1 inhibitor that enhances PARP blockade and reverses osimertinib resistance.,2026,10.1126/sciadv.aeg1996,https://pubmed.ncbi.nlm.nih.gov/42555732/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,39399646,Penfluridol inhibits melanoma growth and metastasis through enhancing von Hippel‒Lindau tumor suppressor-mediated cancerous inhibitor of protein phosphatase 2A (CIP2A) degradation.,2024,10.1002/mco2.758,https://pubmed.ncbi.nlm.nih.gov/39399646/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,39987600,Circular RNA Vav3 mediated ALV-J inhibition of autophagy by modulating the gga-miR-375/CIP2A axis and activating AKT.,2025,10.1016/j.psj.2025.104923,https://pubmed.ncbi.nlm.nih.gov/39987600/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,42140456,"Micropeptides in Cancer and Immunity: Diagnostic, Therapeutic, and Synthetic Biology Frontiers.",2026,10.1016/j.gene.2026.150217,https://pubmed.ncbi.nlm.nih.gov/42140456/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,42715921,Preparation of monoclonal antibodies against Echinococcus multilocularis CIP2A and development of blocking and sandwich ELISAs.,2026,10.1016/j.vetpar.2026.110916,https://pubmed.ncbi.nlm.nih.gov/42715921/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,41102956,"Traditional Design and Modification of ""Celastrol"" Nano-Delivery Systems for Cancer: A Review.",2025,10.2174/0115680266418981250929223913,https://pubmed.ncbi.nlm.nih.gov/41102956/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,39615212,CIP2A inhibitors TD52 and Ethoxysanguinarine promote macrophage autophagy and alleviates acute pancreatitis by modulating the AKT-mTOR pathway.,2025,10.1016/j.phymed.2024.156263,https://pubmed.ncbi.nlm.nih.gov/39615212/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,38819231,Chronic stress induces Alzheimer's disease-like pathologies through DNA damage-Chk1-CIP2A signaling.,2024,10.18632/aging.205862,https://pubmed.ncbi.nlm.nih.gov/38819231/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,40354992,A PP2A-mtATR-tBid axis links DNA damage-induced CIP2A degradation to apoptotic dormancy and therapeutic resistance in PDAC.,2025,10.1016/j.canlet.2025.217790,https://pubmed.ncbi.nlm.nih.gov/40354992/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,37097392,"Cancer progression by the okadaic acid class of tumor promoters and endogenous protein inhibitors of PP2A, SET and CIP2A.",2023,10.1007/s00432-023-04800-4,https://pubmed.ncbi.nlm.nih.gov/37097392/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,39963741,Multifaceted Therapeutic Impacts of Cucurbitacin B: Recent Evidences From Preclinical Studies.,2025,10.1002/ptr.8454,https://pubmed.ncbi.nlm.nih.gov/39963741/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,17632056,CIP2A inhibits PP2A in human malignancies.,2007,10.1016/j.cell.2007.04.044,https://pubmed.ncbi.nlm.nih.gov/17632056/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CIP2A,ENSG00000163507,Unsafe,12118381,Cloning and characterization of a novel 90 kDa 'companion' auto-antigen of p62 overexpressed in cancer.,2002,10.1038/sj.onc.1205625,https://pubmed.ncbi.nlm.nih.gov/12118381/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,41370039,Filippi syndrome-associated CKAP2L modulates microtubule dynamics essential for mitosis and ciliary length regulation.,2026,10.1093/jmcb/mjaf054,https://pubmed.ncbi.nlm.nih.gov/41370039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,42245708,CKAP2L promotes endometrial cancer progression by suppressing AKT ubiquitination and activating the PI3K/AKT signaling pathway.,2026,10.3389/fonc.2026.1764141,https://pubmed.ncbi.nlm.nih.gov/42245708/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,41823522,Smoking promotes colorectal cancer via the CKAP2L/AREG axis.,2026,10.3892/ijo.2026.5872,https://pubmed.ncbi.nlm.nih.gov/41823522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,42105234,Proximity labeling proteomics maps radial glial ciliary proteins across the developing telencephalon.,2026,10.1016/j.celrep.2026.117355,https://pubmed.ncbi.nlm.nih.gov/42105234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,42404495,Clinical and Genetic Spectrum of Filippi Syndrome: A Systematic Review of Published Case Reports and Case Series.,2026,10.1002/hsr2.72655,https://pubmed.ncbi.nlm.nih.gov/42404495/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,40229458,Exosomal circ_0001583 Drives Glioblastoma Cell Advancement Through the miR-647/CKAP2L Pathway.,2025,10.1007/s12035-025-04875-9,https://pubmed.ncbi.nlm.nih.gov/40229458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,39073037,Human CKAP2L shows a cell cycle-dependent expression pattern and exhibits microtubule-stabilizing properties.,2024,10.1002/2211-5463.13864,https://pubmed.ncbi.nlm.nih.gov/39073037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,42342642,[Research progress of genetic study on Filippi syndrome].,2026,10.3760/cma.j.cn511374-20251028-00627,https://pubmed.ncbi.nlm.nih.gov/42342642/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,40646610,Smoking promotes the progression of bladder cancer through FOXM1/CKAP2L axis.,2025,10.1186/s12967-025-06835-2,https://pubmed.ncbi.nlm.nih.gov/40646610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,41583004,Exploring rare coding variants in UK biobank: preliminary associations with motor neuron disease.,2025,10.3389/fnagi.2025.1735522,https://pubmed.ncbi.nlm.nih.gov/41583004/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,39851233,&lt;i&gt;CKAP2L&lt;/i&gt; Plays a Pivotal Role in Colorectal Cancer Progression via the Dual Regulation of Cell Cycle and Epithelial-Mesenchymal Transition.,2025,10.24976/discov.med.202537192.15,https://pubmed.ncbi.nlm.nih.gov/39851233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,41456064,Unraveling the molecular landscape of pancreatic cancer: a systems biology approach to identify therapeutic targets.,2025,10.1007/s12672-025-04197-1,https://pubmed.ncbi.nlm.nih.gov/41456064/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,41179328,"Identification of Prognostic Gene Signatures for Survival of Patients With Phaeochromocytoma, Paraganglioma, and Other Tumor Types.",2025,10.21873/cdp.10497,https://pubmed.ncbi.nlm.nih.gov/41179328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,37225919,Pan-cancer analysis reveals the prognostic and immunotherapeutic value of cytoskeleton-associated protein 2-like.,2023,10.1038/s41598-023-35633-3,https://pubmed.ncbi.nlm.nih.gov/37225919/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,34631884,"CKAP2L, as an Independent Risk Factor, Closely Related to the Prognosis of Glioma.",2021,10.1155/2021/5486131,https://pubmed.ncbi.nlm.nih.gov/34631884/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,36090903,CKAP2L Promotes Esophageal Squamous Cell Carcinoma Progression and Drug-Resistance by Modulating Cell Cycle.,2022,10.1155/2022/2378253,https://pubmed.ncbi.nlm.nih.gov/36090903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,35715760,"CKAP2L, a crucial target of miR-326, promotes prostate cancer progression.",2022,10.1186/s12885-022-09762-3,https://pubmed.ncbi.nlm.nih.gov/35715760/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,33375517,CKAP2L Knockdown Exerts Antitumor Effects by Increasing miR-4496 in Glioblastoma Cell Lines.,2020,10.3390/ijms22010197,https://pubmed.ncbi.nlm.nih.gov/33375517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,37665628,IGF2BP2 promotes ovarian cancer growth and metastasis by upregulating CKAP2L protein expression in an m6 A-dependent manner.,2023,10.1096/fj.202202145rrr,https://pubmed.ncbi.nlm.nih.gov/37665628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,40722386,Detection of LUAD-Associated Genes Using Wasserstein Distance in Multiomics Feature Selection.,2025,10.3390/bioengineering12070694,https://pubmed.ncbi.nlm.nih.gov/40722386/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,37342680,Identification of a Novel Myc-Regulated Gene Signature for Patients with Kidney Renal Clear Cell Carcinoma.,2022,10.1155/2022/3487859,https://pubmed.ncbi.nlm.nih.gov/37342680/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,36699449,Prognostic significance of CKAP2L expression in patients with clear cell renal cell carcinoma.,2022,10.3389/fgene.2022.873884,https://pubmed.ncbi.nlm.nih.gov/36699449/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,33082784,Cancer Stem Cell Characteristics by Network Analysis of Transcriptome Data Stemness Indices in Breast Carcinoma.,2020,10.1155/2020/8841622,https://pubmed.ncbi.nlm.nih.gov/33082784/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,29843710,Gene expression of the liver of vaccination-protected mice in response to early patent infections of Plasmodium chabaudi blood-stage malaria.,2018,10.1186/s12936-018-2366-6,https://pubmed.ncbi.nlm.nih.gov/29843710/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKAP2L,ENSG00000169607,Unsafe,31758680,Identification of Hub Genes Using Co-Expression Network Analysis in Breast Cancer as a Tool to Predict Different Stages.,2019,10.12659/msm.919046,https://pubmed.ncbi.nlm.nih.gov/31758680/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,42400033,Identification and experimental validation of biomarkers associated with T cell infiltration in psoriasis.,2026,10.1186/s41065-026-00707-5,https://pubmed.ncbi.nlm.nih.gov/42400033/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,41763168,A multi-omics R-loop-linked risk program highlights CKS2-positive proliferative tumor cells as drivers of glioma growth.,2026,10.1016/j.intimp.2026.116421,https://pubmed.ncbi.nlm.nih.gov/41763168/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,41981464,The transcription factor E4F1 is crucial for spermatogonial differentiation and meiosis progression in mice.,2026,10.1186/s12864-026-12649-3,https://pubmed.ncbi.nlm.nih.gov/41981464/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,42553741,A Platform-Independent Binary Gene-Pair Signature Derived from CRPC-Enriched Single-Cell Transcriptomics for Predicting Recurrence-Free Survival in Prostate Cancer.,2026,10.2147/cmar.s623563,https://pubmed.ncbi.nlm.nih.gov/42553741/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,40950663,Facilitation of natural killer T-cell cytotoxic activity in uterine sarcoma via the &lt;i&gt;CKS2-PI3K-AKT-MICA&lt;/i&gt; axis.,2025,10.21037/tcr-2025-1405,https://pubmed.ncbi.nlm.nih.gov/40950663/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,40908951,CKS2 Mediates Hepatocellular Carcinoma Recurrence After Hepatic Ischemia-Reperfusion Injury Related to M2 Macrophages.,2025,10.2147/jir.s543147,https://pubmed.ncbi.nlm.nih.gov/40908951/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,41822976,"CKS2, regulated by METTL3, contributes to osteosarcoma progression in an IGF2BP1-dependent manner.",2026,10.1080/08830185.2026.2641449,https://pubmed.ncbi.nlm.nih.gov/41822976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,41200902,CKS2 promotes the malignant phenotypes of bladder cancer cells via PI3K/AKT signaling pathway activation.,2025,10.1080/15384101.2025.2586117,https://pubmed.ncbi.nlm.nih.gov/41200902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,41166795,Synergistic dual oncogenic role of CKS2 and ACAT2: Enhanced regulatory coherence and biomarker potential in adrenocortical carcinoma.,2025,10.1016/j.cancergen.2025.10.103,https://pubmed.ncbi.nlm.nih.gov/41166795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,42410766,Bioinformatic identification of genes and mechanisms related to acute respiratory distress syndrome and sepsis: A bioinformatic study.,2026,10.1097/md.0000000000049521,https://pubmed.ncbi.nlm.nih.gov/42410766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,40092696,CKS2 Silencing Affects Proliferation and Apoptosis in Multiple Myeloma through the PTEN/ AKT/mTOR Pathway.,2025,10.7150/jca.106190,https://pubmed.ncbi.nlm.nih.gov/40092696/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,41165830,m6A-mediated upregulation of miR-3690 drives HNSCC progression by regulating nuclear-cytoplasmic signaling pathway.,2025,10.1007/s00018-025-05875-7,https://pubmed.ncbi.nlm.nih.gov/41165830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,40676553,DNMT1 blocks SOX21-repressed CKS2 transcription to promote gastric cancer progression.,2025,10.1186/s12885-025-14577-z,https://pubmed.ncbi.nlm.nih.gov/40676553/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,41061391,CKS2 is overexpressed in high-grade and recurrent meningiomas and functions as an oncogene via the CKS2/miR-26a/miR-101 axis.,2025,10.1016/j.compbiomed.2025.111142,https://pubmed.ncbi.nlm.nih.gov/41061391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,39188686,Biological functions and therapeutic potential of CKS2 in human cancer.,2024,10.3389/fonc.2024.1424569,https://pubmed.ncbi.nlm.nih.gov/39188686/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,39548421,CKS2 induces autophagy-mediated glutathione metabolic reprogramming to facilitate ferroptosis resistance in colon cancer.,2024,10.1186/s10020-024-00979-5,https://pubmed.ncbi.nlm.nih.gov/39548421/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,41010991,Curcumin as an Epigenetic Modulator: Suppression of Breast Cancer via the Hsa_circ_0001946/MiR-7-5p/Target Gene Axis.,2025,10.3390/medicina61091600,https://pubmed.ncbi.nlm.nih.gov/41010991/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,39560180,Unveiling CKS2: A Key Player in Aggressive B-Cell Lymphoma Progression and a Target for Synergistic Therapy.,2024,10.1002/cam4.70435,https://pubmed.ncbi.nlm.nih.gov/39560180/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,40696188,Nuclear Transport Receptor Importin-β Inhibition Enhances Cell Cycle Arrest Induced by CKS2 Knockdown to Suppress Neuroblastoma Progression.,2025,10.1007/s11064-025-04488-7,https://pubmed.ncbi.nlm.nih.gov/40696188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,39262475,Upregulation of CKS2 in immunosuppressive cells is associated with metastasis and poor prognosis in prostate cancer: a single-cell RNA-sequencing analysis.,2024,10.21037/tcr-23-2100,https://pubmed.ncbi.nlm.nih.gov/39262475/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,41950730,Characterization of cyclotide Vdif A from Viola diffusa inhibits non-small cell lung cancer cells via regulation of CKS2.,2026,10.1016/j.phymed.2026.158146,https://pubmed.ncbi.nlm.nih.gov/41950730/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,37841370,Expression of CKS2 in Hepatocellular Carcinoma: Correlation with Survival Outcomes and Immune Microenvironment.,2023,10.2147/jhc.s427624,https://pubmed.ncbi.nlm.nih.gov/37841370/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,40496041,Clinical significance of cyclin-dependent kinase inhibitor 3 in hepatocellular carcinoma.,2025,10.3892/mco.2025.2860,https://pubmed.ncbi.nlm.nih.gov/40496041/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,41048345,Identification and therapeutic investigation of biomarker genes underpinning hepatocellular carcinoma: an &lt;i&gt;in silico&lt;/i&gt; study utilising molecular docking and dynamics simulation.,2025,10.3389/fbinf.2025.1567748,https://pubmed.ncbi.nlm.nih.gov/41048345/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,41970808,A multi-approach investigation of &lt;i&gt;Rigidoporus ulmarius&lt;/i&gt; as a promising source of nutraceutical leads against diabetes and triple negative breast cancer.,2026,10.1007/s40203-026-00617-4,https://pubmed.ncbi.nlm.nih.gov/41970808/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,37320872,Heterogeneity of cancer-associated fibroblasts in head and neck squamous cell carcinoma.,2023,10.1016/j.tranon.2023.101717,https://pubmed.ncbi.nlm.nih.gov/37320872/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,40599792,Precision prognostication in neuroblastomas via clinically validated E2F activity signatures.,2025,10.3389/fimmu.2025.1612667,https://pubmed.ncbi.nlm.nih.gov/40599792/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CKS2,ENSG00000123975,Unsafe,41240503,"Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in multiple myeloma.",2026,10.1016/j.tranon.2025.102601,https://pubmed.ncbi.nlm.nih.gov/41240503/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,41073135,Claudin 6 is a suitable target for CAR T-cell therapy in atypical teratoid/rhabdoid brain tumors and other pediatric solid tumors.,2025,10.1136/jitc-2025-011709,https://pubmed.ncbi.nlm.nih.gov/41073135/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,41835342,Evaluating Claudin-6 and isochromosome 12p in the progression from germ cell neoplasia in situ to primary testicular germ cell tumor and post-chemotherapy teratoma: implications for CLDN6-targeted therapies.,2026,10.1177/17588359261421810,https://pubmed.ncbi.nlm.nih.gov/41835342/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,41804857,"Overcoming claudin family homology: discovery of ARC101, a highly potent CLDN6-specific T-cell engager with a novel CD3 binder for ovarian adenocarcinoma.",2026,10.1080/19420862.2026.2637299,https://pubmed.ncbi.nlm.nih.gov/41804857/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,41810339,Role of claudin-6 in high-grade endometrial carcinoma: Implications for risk stratification and personalized treatment strategies.,2026,10.5306/wjco.v17.i2.116390,https://pubmed.ncbi.nlm.nih.gov/41810339/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,42065778,A combined hematological and molecular study of Hodgkin lymphoma in Palestine: insights into subtype-specific prognosis and the role of Claudin-6/GATA-4.,2026,10.1007/s00277-026-07037-6,https://pubmed.ncbi.nlm.nih.gov/42065778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,41882748,A novel CLDN6 nanobody-based bispecific T-cell engager delivered by self-amplifying RNA platform exhibits potent antitumor efficacy.,2026,10.1186/s12951-026-04319-z,https://pubmed.ncbi.nlm.nih.gov/41882748/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,42378456,Comprehensive Profiling of Cell Surface Proteins in Testicular Germ Cell Tumors.,2026,10.1158/2767-9764.crc-26-0246,https://pubmed.ncbi.nlm.nih.gov/42378456/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,42259433,"CLDN6 in cancer: Biology, clinical significance, and emerging therapeutic strategies.",2026,10.1016/j.phrs.2026.108276,https://pubmed.ncbi.nlm.nih.gov/42259433/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,42072801,Prognostic and Predictive Significance of Claudin-6 Expression in Advanced-Stage High-Grade Serous Ovarian Carcinoma.,2026,10.3390/diagnostics16081175,https://pubmed.ncbi.nlm.nih.gov/42072801/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,41628300,CLDN6 Expression Plasticity in Ovarian Cancer: Insights into Therapeutic Optimization for CLDN6-Targeted Immunotherapy.,2026,10.1158/2767-9764.crc-25-0399,https://pubmed.ncbi.nlm.nih.gov/41628300/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,42180101,Antibody-drug conjugates for primary brain tumors.,2026,10.3389/fonc.2026.1811494,https://pubmed.ncbi.nlm.nih.gov/42180101/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,41923292,The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors.,2026,10.1111/andr.70217,https://pubmed.ncbi.nlm.nih.gov/41923292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,42682961,A clinically derived lipid-endothelial signature links serum multi-omics to immune exclusion and clinical stratification in hepatocellular carcinoma.,2026,10.1177/17588359261481797,https://pubmed.ncbi.nlm.nih.gov/42682961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,42866595,A zinc organic metal skeleton vaccine for lung cancer treatment can stimulate strong innate and adaptive anti-tumor immunity.,2026,10.1016/j.mtbio.2026.103719,https://pubmed.ncbi.nlm.nih.gov/42866595/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,40149257,The Chimeric Antigen Receptor T Cell Target Claudin 6 Is a Marker for Early Organ-Specific Epithelial Progenitors and Is Expressed in Some Pediatric Solid Tumor Entities.,2025,10.3390/cancers17060920,https://pubmed.ncbi.nlm.nih.gov/40149257/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,41267074,De novo design of a two-step approach targeting Claudin-6 for enhanced drug delivery to solid tumors.,2025,10.1186/s12967-025-07316-2,https://pubmed.ncbi.nlm.nih.gov/41267074/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,41355918,Tight junction disruption &lt;i&gt;via&lt;/i&gt; claudin-6 overexpression promotes invasion and recurrence in high-grade endometrial tumors.,2025,10.5306/wjco.v16.i11.110257,https://pubmed.ncbi.nlm.nih.gov/41355918/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,42070760,CLDN6 inhibits breast cancer growth by inducing autophagic cell death through SOX4 m6A modification.,2026,10.1016/j.cellsig.2026.112570,https://pubmed.ncbi.nlm.nih.gov/42070760/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,39915118,&lt;sup&gt;177&lt;/sup&gt;Lu-Labeled Anticlaudin 6 Monoclonal Antibody for Targeted Therapy in Esophageal Cancer.,2025,10.2967/jnumed.124.268487,https://pubmed.ncbi.nlm.nih.gov/39915118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,41351424,Therapeutic Potential of CLDN Family Proteins in Ovarian Cancer: Emerging Biomarkers and Targets.,2025,10.31083/fbl45244,https://pubmed.ncbi.nlm.nih.gov/41351424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,42239618,Treatment options in platinum-refractory male germ cell cancers: current standards and future directions.,2026,10.1177/17588359261451841,https://pubmed.ncbi.nlm.nih.gov/42239618/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,42534594,Antibody drug conjugates in gynaecological cancers: navigating between opportunities and challenges.,2026,10.1016/j.eclinm.2026.103895,https://pubmed.ncbi.nlm.nih.gov/42534594/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,42824309,Biomarker-Driven Treatments for Ovarian Cancer: Moving Beyond HRD?,2026,10.2147/ijwh.s571328,https://pubmed.ncbi.nlm.nih.gov/42824309/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,40645662,Shared epitopes create safety and efficacy concerns in several cancer vaccines.,2025,10.1136/jitc-2025-012217,https://pubmed.ncbi.nlm.nih.gov/40645662/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,39401967,"SAIL66, a next generation CLDN6-targeting T-cell engager, demonstrates potent antitumor efficacy through dual binding to CD3/CD137.",2024,10.1136/jitc-2024-009563,https://pubmed.ncbi.nlm.nih.gov/39401967/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,37872225,CLDN6-specific CAR-T cells plus amplifying RNA vaccine in relapsed or refractory solid tumors: the phase 1 BNT211-01 trial.,2023,10.1038/s41591-023-02612-0,https://pubmed.ncbi.nlm.nih.gov/37872225/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLDN6,ENSG00000184697,Unsafe,17804490,Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus.,2007,10.1128/jvi.01457-07,https://pubmed.ncbi.nlm.nih.gov/17804490/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,41844941,Targeting NK cell CLEC12B enhances cancer immunotherapy.,2026,10.1038/s41590-026-02471-0,https://pubmed.ncbi.nlm.nih.gov/41844941/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,39550977,New biological markers in diagnosis and follow-up of brucellosis cases.,2025,10.1016/j.diagmicrobio.2024.116587,https://pubmed.ncbi.nlm.nih.gov/39550977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,40539042,Unveiling regulatory variants in the blood transcriptome and their association with immunity traits in pigs.,2025,10.3389/fimmu.2025.1582982,https://pubmed.ncbi.nlm.nih.gov/40539042/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,36198379,A novel C-type lectin (CLEC12B) from Nile tilapia (Oreochromis niloticus) is involved in host defense against bacterial infection.,2022,10.1016/j.fsi.2022.09.073,https://pubmed.ncbi.nlm.nih.gov/36198379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,37583471,Integrative bioinformatics and artificial intelligence analyses of transcriptomics data identified genes associated with major depressive disorders including NRG1.,2023,10.1016/j.ynstr.2023.100555,https://pubmed.ncbi.nlm.nih.gov/37583471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,37294293,CLEC4A and CLEC12B C-type lectin receptors mediate interactions with &lt;i&gt;Pneumocystis&lt;/i&gt; cell wall components.,2023,10.1099/jmm.0.001714,https://pubmed.ncbi.nlm.nih.gov/37294293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,34780782,CLEC12B suppresses lung cancer progression by inducing SHP-1 expression and inactivating the PI3K/AKT signaling pathway.,2021,10.1016/j.yexcr.2021.112914,https://pubmed.ncbi.nlm.nih.gov/34780782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,34896119,CLEC12B Is a Melanocytic Gene Regulating the Color of the Skin.,2022,10.1016/j.jid.2021.08.450,https://pubmed.ncbi.nlm.nih.gov/34896119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,34310951,CLEC12B Decreases Melanoma Proliferation by Repressing Signal Transducer and Activator of Transcription 3.,2022,10.1016/j.jid.2021.05.035,https://pubmed.ncbi.nlm.nih.gov/34310951/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,34020140,"Selective expression of a C-type lectin receptor, Clec12b, on skin mast cells.",2021,10.1016/j.bbrc.2021.04.097,https://pubmed.ncbi.nlm.nih.gov/34020140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,34246465,"Corrigendum to selective expression of a C-type lectin receptor, Clec12b, on skin mast cells.",2021,10.1016/j.bbrc.2021.07.009,https://pubmed.ncbi.nlm.nih.gov/34246465/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,34887858,Identification of Immune-Related Gene Signatures in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma.,2021,10.3389/fimmu.2021.752643,https://pubmed.ncbi.nlm.nih.gov/34887858/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,33592571,Expression of CLEC4A in porcine tissues and leukocyte populations and characterization of mRNA splice variants.,2021,10.1016/j.molimm.2021.01.027,https://pubmed.ncbi.nlm.nih.gov/33592571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,36213116,Nutritional immunomodulation of Atlantic salmon response to Renibacterium salmoninarum bacterin.,2022,10.3389/fmolb.2022.931548,https://pubmed.ncbi.nlm.nih.gov/36213116/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,35339455,WHO grading system for invasive pulmonary lung adenocarcinoma reveals distinct molecular signature: An analysis from the cancer genome atlas database.,2022,10.1016/j.yexmp.2022.104756,https://pubmed.ncbi.nlm.nih.gov/35339455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,34017580,Identification of key gene modules and pathways of human platelet transcriptome in acute myocardial infarction patients through co-expression network.,2021,,https://pubmed.ncbi.nlm.nih.gov/34017580/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,28440726,Expression of C-type lectin receptor mRNA in chronic otitis media with cholesteatoma.,2017,10.1080/00016489.2016.1269196,https://pubmed.ncbi.nlm.nih.gov/28440726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,24091439,Differential proteomic analysis of caveolin-1 KO cells reveals Sh2b3 and Clec12b as novel interaction partners of caveolin-1 and Capns1 as a potential mediator of caveolin-1-induced apoptosis.,2013,10.1039/c3an36819j,https://pubmed.ncbi.nlm.nih.gov/24091439/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,31770640,Profiling the transcriptome response of Atlantic salmon head kidney to formalin-killed Renibacterium salmoninarum.,2020,10.1016/j.fsi.2019.11.057,https://pubmed.ncbi.nlm.nih.gov/31770640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,17562706,"Identification of CLEC12B, an inhibitory receptor on myeloid cells.",2007,10.1074/jbc.m704250200,https://pubmed.ncbi.nlm.nih.gov/17562706/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,26890122,Behçet's: A Disease or a Syndrome? Answer from an Expression Profiling Study.,2016,10.1371/journal.pone.0149052,https://pubmed.ncbi.nlm.nih.gov/26890122/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,19025564,"The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors.",2009,10.1111/j.1574-6968.2008.01418.x,https://pubmed.ncbi.nlm.nih.gov/19025564/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC12B,ENSG00000256660,Unsafe,19596987,"Microarray analysis of lymphatic tissue reveals stage-specific, gene expression signatures in HIV-1 infection.",2009,10.4049/jimmunol.0803222,https://pubmed.ncbi.nlm.nih.gov/19596987/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC18A,ENSG00000157322,Unsafe,42699694,Spatially Contextualized Integrative Genomics Highlights Neuronal and Glial Regulatory Programs in Low Back Pain.,2026,10.2147/jpr.s619982,https://pubmed.ncbi.nlm.nih.gov/42699694/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC18A,ENSG00000157322,Unsafe,40847602,CLEC18A interacts with sulfated glycosaminoglycans and controls clear cell renal cell carcinoma progression.,2026,10.1111/febs.70236,https://pubmed.ncbi.nlm.nih.gov/40847602/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC18A,ENSG00000157322,Unsafe,42790802,Protective effects of sarcopenia-related traits on spinal degenerative diseases: A large prospective cohort study.,2026,10.1016/j.bone.2026.118113,https://pubmed.ncbi.nlm.nih.gov/42790802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC18A,ENSG00000157322,Unsafe,37154715,CLEC18A Impairs Phagocytosis by Reducing FcγRIIA Expression and Arresting Autophagosome-Lysosome Fusion.,2023,10.1128/spectrum.02903-22,https://pubmed.ncbi.nlm.nih.gov/37154715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC18A,ENSG00000157322,Unsafe,35717171,Human rs75776403 polymorphism links differential phenotypic and clinical outcomes to a CLEC18A p.T151M-driven multiomics.,2022,10.1186/s12929-022-00822-1,https://pubmed.ncbi.nlm.nih.gov/35717171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC18A,ENSG00000157322,Unsafe,33603190,Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.,2021,10.1038/s42003-021-01745-7,https://pubmed.ncbi.nlm.nih.gov/33603190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC18A,ENSG00000157322,Unsafe,40256241,The diagnostic and prognostic value of &lt;i&gt;C1orf174&lt;/i&gt; in colorectal cancer.,2025,10.34172/bi.30566,https://pubmed.ncbi.nlm.nih.gov/40256241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC18A,ENSG00000157322,Unsafe,33767710,Transgenic Expression of Human C-Type Lectin Protein CLEC18A Reduces Dengue Virus Type 2 Infectivity in Aedes aegypti.,2021,10.3389/fimmu.2021.640367,https://pubmed.ncbi.nlm.nih.gov/33767710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC18A,ENSG00000157322,Unsafe,37264314,An N6-methyladenosine regulation- and mRNAsi-related prognostic index reveals the distinct immune microenvironment and immunotherapy responses in lower-grade glioma.,2023,10.1186/s12859-023-05328-7,https://pubmed.ncbi.nlm.nih.gov/37264314/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC18A,ENSG00000157322,Unsafe,38764023,Characterization of the genetic variation and evolutionary divergence of the CLEC18 family.,2024,10.1186/s12929-024-01034-5,https://pubmed.ncbi.nlm.nih.gov/38764023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC18A,ENSG00000157322,Unsafe,36072903,Epithelial-Mesenchymal Transition Gene Signature Is Associated with Neoadjuvant Chemoradiotherapy Resistance and Prognosis of Esophageal Squamous Cell Carcinoma.,2022,10.1155/2022/3534433,https://pubmed.ncbi.nlm.nih.gov/36072903/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC18A,ENSG00000157322,Unsafe,26170455,Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.,2015,10.1074/jbc.m115.649814,https://pubmed.ncbi.nlm.nih.gov/26170455/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC18A,ENSG00000157322,Unsafe,34979452,"Evaluation of blood cell viability rate, gene expression, and O-GlcNAcylation profiles as indicative signatures for fungal stimulation of salmonid cell models.",2022,10.1016/j.molimm.2021.12.019,https://pubmed.ncbi.nlm.nih.gov/34979452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,42688053,CD161 and LLT1 expression in immune cell populations of Hodgkin lymphoma tumor microenvironment.,2026,10.3389/fmed.2026.1914176,https://pubmed.ncbi.nlm.nih.gov/42688053/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,41884120,Reed-Sternberg cells express CD161 and lectin-like transcript 1 in Hodgkin lymphoma.,2026,10.3389/fmed.2026.1754727,https://pubmed.ncbi.nlm.nih.gov/41884120/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,42389507,Longitudinal Single-Cell Transcriptomic Profiling Reveals Dynamic Immune Cell Alterations During Burosumab Therapy in X-Linked Hypophosphatemia.,2026,10.1002/pdi3.70053,https://pubmed.ncbi.nlm.nih.gov/42389507/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,42021381,Single-cell analysis highlights the role of CD4&lt;sup&gt;+&lt;/sup&gt; IFN-I-related T cells in Behcet's uveitis during Interferonα-2a therapy.,2026,10.1186/s13062-026-00810-7,https://pubmed.ncbi.nlm.nih.gov/42021381/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,40938562,C-type lectin-like domain family 2 (CLEC2D) promotes proliferation and migration of breast cancer and serves as a poor prognostic factor.,2026,10.1007/s12282-025-01777-5,https://pubmed.ncbi.nlm.nih.gov/40938562/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,40855628,Targeting of the CD161 Inhibitory Receptor Enhances Bone-Marrow-Resident Memory CD8&lt;sup&gt;+&lt;/sup&gt; T-Cell-Mediated Immunity against Multiple Myeloma.,2025,10.1002/advs.202510888,https://pubmed.ncbi.nlm.nih.gov/40855628/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,42212143,dNK3 cells in normal pregnancy and recurrent pregnancy loss: from molecular identity to functional imbalance.,2026,10.3389/fimmu.2026.1822205,https://pubmed.ncbi.nlm.nih.gov/42212143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,41144390,"Expression, Clinical Significance, and Role in Immunotherapy Efficacy Evaluation of the Co-stimulatory Molecule LLT1 in Gastric Cancer.",2025,10.3791/68827,https://pubmed.ncbi.nlm.nih.gov/41144390/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,38502058,Immune checkpoint CD161/LLT1-associated immunological landscape and diagnostic value in oral squamous cell carcinoma.,2024,10.1002/cjp2.353,https://pubmed.ncbi.nlm.nih.gov/38502058/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,39511540,Targeting LLT1 as a potential immunotherapy option for cancer patients non-responsive to existing checkpoint therapies in multiple solid tumors.,2024,10.1186/s12885-024-13074-z,https://pubmed.ncbi.nlm.nih.gov/39511540/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,37287972,SARS-CoV-2 infection impairs NK cell functions via activation of the LLT1-CD161 axis.,2023,10.3389/fimmu.2023.1123155,https://pubmed.ncbi.nlm.nih.gov/37287972/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,40564131,Altered Expression of NK Receptors in Racially/Ethnically Diverse and Risk-of-Relapse Pediatric Acute Lymphoblastic Leukemia Patients.,2025,10.3390/biomedicines13061412,https://pubmed.ncbi.nlm.nih.gov/40564131/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,41898418,A Rapid Active-Latent-Relapse Murine Model of Tuberculosis Based Blood Transcriptional Signature That Distinguishes Disease Stages.,2026,10.3390/ijms27062554,https://pubmed.ncbi.nlm.nih.gov/41898418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,42865850,Single-cell landscape of lymphoid and myeloid heterogeneity across type-stratified craniofacial lesions in polyostotic fibrous dysplasia.,2026,10.3389/fimmu.2026.1906418,https://pubmed.ncbi.nlm.nih.gov/42865850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,39856752,LLT1 overexpression renders allogeneic-NK resistance and facilitates the generation of enhanced universal CAR-T cells.,2025,10.1186/s13046-025-03273-2,https://pubmed.ncbi.nlm.nih.gov/39856752/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,41978270,Characterization of NLRP3 Inflammasome-Associated Hub Genes in the Progression of Diabetic Nephropathy.,2026,10.1002/iid3.70424,https://pubmed.ncbi.nlm.nih.gov/41978270/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,41234823,Prognostic significance of key immune cell functional alterations in clear cell renal cell carcinoma.,2025,10.21037/tcr-2025-971,https://pubmed.ncbi.nlm.nih.gov/41234823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,36835271,"Differential Expression of LLT1, SLAM Receptors CS1 and 2B4 and NCR Receptors NKp46 and NKp30 in Pediatric Acute Lymphoblastic Leukemia (ALL).",2023,10.3390/ijms24043860,https://pubmed.ncbi.nlm.nih.gov/36835271/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,38673902,Lectin-like Transcript-1 (LLT1) Expression in Oral Squamous Cell Carcinomas: Prognostic Significance and Relationship with the Tumor Immune Microenvironment.,2024,10.3390/ijms25084314,https://pubmed.ncbi.nlm.nih.gov/38673902/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,33255617,Lectin-Like Transcript 1 (LLT1) Checkpoint: A Novel Independent Prognostic Factor in HPV-Negative Oropharyngeal Squamous Cell Carcinoma.,2020,10.3390/biomedicines8120535,https://pubmed.ncbi.nlm.nih.gov/33255617/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,41899434,Novel Immunotherapeutic Strategies for Castration-Resistant Prostate Cancer: Mechanisms and Clinical Advances.,2026,10.3390/cimb48030282,https://pubmed.ncbi.nlm.nih.gov/41899434/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,42455319,"Immunotherapeutic strategies for castration-resistant prostate cancer: A systematic review of mechanisms, clinical advances and emerging approaches.",2026,10.1007/s11033-026-12340-6,https://pubmed.ncbi.nlm.nih.gov/42455319/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,40171839,Combined CLEC2d Expression and CD58 Loss Mitigate Rejection of Allogeneic T Cells.,2025,10.1097/cji.0000000000000552,https://pubmed.ncbi.nlm.nih.gov/40171839/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,39329751,Prospective Molecular Targets for Natural Killer Cell Immunotherapy against Glioblastoma Multiforme.,2024,10.3390/cells13181567,https://pubmed.ncbi.nlm.nih.gov/39329751/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,40596554,A novel necroptosis related prognostic signature for skin cutaneous melanoma based on transcriptome and single cell sequencing analysis.,2025,10.1038/s41598-025-07829-2,https://pubmed.ncbi.nlm.nih.gov/40596554/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,38153903,Targeting of the CD161 inhibitory receptor enhances T-cell-mediated immunity against hematological malignancies.,2024,10.1182/blood.2023022882,https://pubmed.ncbi.nlm.nih.gov/38153903/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,20843815,Characterization of alternatively spliced transcript variants of CLEC2D gene.,2010,10.1074/jbc.m110.179622,https://pubmed.ncbi.nlm.nih.gov/20843815/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC2D,ENSG00000069493,Unsafe,10541800,Cloning of a new lectin-like receptor expressed on human NK cells.,1999,10.1007/s002510050679,https://pubmed.ncbi.nlm.nih.gov/10541800/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,41918372,In Vitro Antimicrobial Activity and In Vivo Intestinal Barrier Regulation by Commiphora leptophloeos Bark Extract in 5-Fluorouracil-Induced Mucositis.,2026,10.1002/cbdv.202503251,https://pubmed.ncbi.nlm.nih.gov/41918372/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,41777892,"BDCA2 plays a central role in the binding, internalization and response of plasmacytoid dendritic cells to vidutolimod.",2026,10.3389/fimmu.2026.1769287,https://pubmed.ncbi.nlm.nih.gov/41777892/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,42760567,Stress-driven reprogramming of plasmacytoid dendritic cells in intrahepatic cholangiocarcinoma defines a reversible targetable immunosuppressive state.,2026,10.1186/s12957-026-04489-y,https://pubmed.ncbi.nlm.nih.gov/42760567/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,41836419,Automated manufacturing of clinical-grade BDCA2 CAR NK cells in a closed system for the treatment of blastic plasmacytoid dendritic cell neoplasm.,2026,10.3389/fimmu.2026.1761397,https://pubmed.ncbi.nlm.nih.gov/41836419/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,41662631,Targeting donor XCR1+ and CD11b+ dendritic cells prevents Th1- and Th17-dependent GVHD within the gastrointestinal tract.,2026,10.1182/blood.2025029431,https://pubmed.ncbi.nlm.nih.gov/41662631/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,40691155,Mimicking the myoseptum in cultivated fish by manufacturing edible microalgae-rich nanofibers.,2025,10.1038/s41538-025-00508-6,https://pubmed.ncbi.nlm.nih.gov/40691155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,42312026,High-salt diet promotes atopic dermatitis by partially enhancing intestinal SGK1/ENaC signaling and destroying gut &lt;i&gt;Lactobacillus&lt;/i&gt;-maintained systemic type 1 interferon.,2026,10.3389/fcimb.2026.1794494,https://pubmed.ncbi.nlm.nih.gov/42312026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,40553558,Immunohistochemical Expression of Plasmacytoid Dendritic Cell Markers in Cutaneous Lupus Erythematosus Subtypes in Skin of Color.,2025,10.1097/dad.0000000000003033,https://pubmed.ncbi.nlm.nih.gov/40553558/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,39779579,Identification of a Novel Immune-Gene Signature with Prognostic Value in Patients with Head and Neck Cancer: A Pilot Study.,2026,10.1007/s10528-024-11017-8,https://pubmed.ncbi.nlm.nih.gov/39779579/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,40524185,Immune cell aberrations in Systemic Lupus Erythematosus: navigating the targeted therapies toward precision management.,2025,10.1186/s11658-025-00749-z,https://pubmed.ncbi.nlm.nih.gov/40524185/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,41668174,BRD4-associated chromatin remodelling signature links epigenetic regulation to immune landscape in ovarian cancer.,2026,10.1186/s13048-026-02022-z,https://pubmed.ncbi.nlm.nih.gov/41668174/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,37184875,An immunomodulatory antibody-drug conjugate targeting BDCA2 strongly suppresses plasmacytoid dendritic cell function and glucocorticoid responsive genes.,2024,10.1093/rheumatology/kead219,https://pubmed.ncbi.nlm.nih.gov/37184875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,39588228,Novel Prognostic Markers for Skin Cutaneous Melanoma.,2024,10.2147/ccid.s486679,https://pubmed.ncbi.nlm.nih.gov/39588228/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,41737206,Long-term left ventricular assist device support reinforces detrimental immunological effects.,2026,10.3389/fimmu.2026.1705980,https://pubmed.ncbi.nlm.nih.gov/41737206/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,39069601,Profiling dendritic cells subsets in renal tissue of patients with crescentic glomerulonephritis.,2025,10.1007/s11255-024-04175-6,https://pubmed.ncbi.nlm.nih.gov/39069601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,40799176,Reduced Type-I Interferon by Plasmacytoid Dendritic Cells and Asthma in School-Aged Children.,2026,10.1111/all.70005,https://pubmed.ncbi.nlm.nih.gov/40799176/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,40332667,Identifying Immune Response Protein Biomarkers in Parkinson's-Related Cognitive Impairment and Depression.,2025,10.1007/s12035-025-05022-0,https://pubmed.ncbi.nlm.nih.gov/40332667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,39536806,Zebrafish use conserved CLR and TLR signaling pathways to respond to fungal PAMPs in zymosan.,2025,10.1016/j.dci.2024.105286,https://pubmed.ncbi.nlm.nih.gov/39536806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,41076212,EED226 treatment targets key immune genes to suppress LPS response in Chinese tongue sole splenocytes.,2026,10.1016/j.fsi.2025.110927,https://pubmed.ncbi.nlm.nih.gov/41076212/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,40752598,Commiphora leptophloeos leaf and bark extracts modulate OxInflammation through TLR4/ NF-κB/ Nrf2 pathways.,2025,10.1016/j.jep.2025.120347,https://pubmed.ncbi.nlm.nih.gov/40752598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,41139044,Mass spectrometry-based major phytochemicals and dose dependent cytotoxic and nephrotoxic effects of Commiphora leptophloeos stem bark extract in preclinical in vitro and in vivo models.,2026,10.1016/j.jep.2025.120779,https://pubmed.ncbi.nlm.nih.gov/41139044/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,42547819,Endoplasmic reticulum stress promotes leukemic plasmacytoid dendritic cell differentiation skewing and immune suppression in acute myeloid leukemia.,2026,10.1038/s41375-026-03080-4,https://pubmed.ncbi.nlm.nih.gov/42547819/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,42522516,Targeted therapies against type I interferon and TNF-alpha in cutaneous lupus erythematosus: A systematic review of randomized trials.,2026,10.25251/mgn4rt3l,https://pubmed.ncbi.nlm.nih.gov/42522516/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,42353651,Antarctic Fish Antimicrobial Peptides Active Against Bacterial and Viral Pathogens of Aquacultural Importance.,2026,10.3390/antibiotics15060527,https://pubmed.ncbi.nlm.nih.gov/42353651/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,37877249,The development of litifilimab (BIIB 059) for cutaneous and systemic lupus erythematosus.,2024,10.2217/imt-2023-0086,https://pubmed.ncbi.nlm.nih.gov/37877249/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,38849082,Siglec-H&lt;sup&gt;-/-&lt;/sup&gt; Plasmacytoid Dendritic Cells Protect Against Acute Liver Injury by Suppressing IFN-γ/Th1 Response and Promoting IL-21&lt;sup&gt;+&lt;/sup&gt; CD4 T Cells.,2024,10.1016/j.jcmgh.2024.101367,https://pubmed.ncbi.nlm.nih.gov/38849082/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,38554841,Elucidating hepatoprotective potential of Cichorium intybus through multimodal assessment and molecular docking analysis with hepatic protective enzymes.,2024,10.1016/j.fct.2024.114595,https://pubmed.ncbi.nlm.nih.gov/38554841/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,40047795,A focused report on IFN-1 targeted therapies for lupus erythematosus.,2025,10.1080/13543784.2025.2473060,https://pubmed.ncbi.nlm.nih.gov/40047795/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,11748283,"BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction.",2001,10.1084/jem.194.12.1823,https://pubmed.ncbi.nlm.nih.gov/11748283/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,11536172,"Molecular and genomic characterization of human DLEC, a novel member of the C-type lectin receptor gene family preferentially expressed on monocyte-derived dendritic cells.",2001,10.1002/1521-4141(200109)31:9<2733::aid-immu2733>3.0.co;2-x,https://pubmed.ncbi.nlm.nih.gov/11536172/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLEC4C,ENSG00000198178,Unsafe,11031109,Identification and characterization of the gene for a novel C-type lectin (CLECSF7) that maps near the natural killer gene complex on human chromosome 12.,2000,10.1006/geno.2000.6316,https://pubmed.ncbi.nlm.nih.gov/11031109/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,40783453,Disruption of TEX38 impairs sperm morphogenesis and the migration of sperm into the oviduct.,2025,10.1038/s42003-025-08644-1,https://pubmed.ncbi.nlm.nih.gov/40783453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,42804753,A Paired Tumor Organoid-Stroma Biobank Reveals PLAU⁺ Fibroblasts as Drivers of Chemoresistance in Lung Adenocarcinoma.,2026,10.1158/0008-5472.can-26-1323,https://pubmed.ncbi.nlm.nih.gov/42804753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,41395613,Targeting endoplasmic reticulum stress-induced CLGN resensitizes hepatocellular carcinoma to apoptosis: paeonol synergistically enhances efficacy by dual inhibition of CLGN and NF-κB.,2025,10.3389/fonc.2025.1709962,https://pubmed.ncbi.nlm.nih.gov/41395613/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,40137503,Oxidative and Molecular-Structural Alterations of Spermatozoa in Swine and Ram Exposed to the Triazole Ipconazole.,2025,10.3390/toxics13030176,https://pubmed.ncbi.nlm.nih.gov/40137503/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,41607685,Design and Validation of a Predictive Model for Hepatocellular Carcinoma Based on Genes With Differential Expression Driven by DNA Methylation.,2026,10.1155/ijog/2729004,https://pubmed.ncbi.nlm.nih.gov/41607685/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,40360188,Alterations of the gut commensal &lt;i&gt;Akkermansia muciniphila&lt;/i&gt; in patients with COVID-19.,2025,10.1080/21505594.2025.2505999,https://pubmed.ncbi.nlm.nih.gov/40360188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,41125435,Identifying Key Regulators in Odorant Receptor Trafficking.,2025,10.1523/jneurosci.0454-25.2025,https://pubmed.ncbi.nlm.nih.gov/41125435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,39553470,Bioinformatical analysis and experimental validation of endoplasmic reticulum stress-related biomarker genes in type 2 diabetes mellitus.,2024,10.3389/fgene.2024.1445033,https://pubmed.ncbi.nlm.nih.gov/39553470/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,41183511,Identification of novel differentiation trajectories and gene network associations with ectopic pregnancy in fallopian tube epithelium.,2025,10.1093/humrep/deaf200,https://pubmed.ncbi.nlm.nih.gov/41183511/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,36698420,The upregulation of CLGN in hepatocellular carcinoma is potentially regulated by hsa-miR-194-3p and associated with patient progression.,2022,10.3389/fonc.2022.1081510,https://pubmed.ncbi.nlm.nih.gov/36698420/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,40218432,Identification of Candidate Genes and eQTLs Related to Porcine Reproductive Function.,2025,10.3390/ani15071038,https://pubmed.ncbi.nlm.nih.gov/40218432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,36765856,Molecular Identification and In Silico Protein Analysis of a Novel BCOR-CLGN Gene Fusion in Intrathoracic BCOR-Rearranged Sarcoma.,2023,10.3390/cancers15030898,https://pubmed.ncbi.nlm.nih.gov/36765856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,39010084,Endoplasmic reticulum stress promotes hepatocellular carcinoma by modulating immunity: a study based on artificial neural networks and single-cell sequencing.,2024,10.1186/s12967-024-05460-9,https://pubmed.ncbi.nlm.nih.gov/39010084/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,40228447,BCOR-rearranged sarcomas: In silico insights into altered domains and BCOR interactions.,2025,10.1016/j.compbiomed.2025.110144,https://pubmed.ncbi.nlm.nih.gov/40228447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,39982030,DNA Methylation and Target Gene Expression in Fatty Liver Progression From Simple Steatosis to Advanced Fibrosis.,2025,10.1111/liv.70040,https://pubmed.ncbi.nlm.nih.gov/39982030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,31865789,Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production.,2020,10.1161/hypertensionaha.119.14062,https://pubmed.ncbi.nlm.nih.gov/31865789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,36291758,Sentinel Lymph Node Gene Expression Signature Predicts Recurrence-Free Survival in Cutaneous Melanoma.,2022,10.3390/cancers14204973,https://pubmed.ncbi.nlm.nih.gov/36291758/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,31514295,Involvement of Dual Strands of miR-143 (miR-143-5p and miR-143-3p) and Their Target Oncogenes in the Molecular Pathogenesis of Lung Adenocarcinoma.,2019,10.3390/ijms20184482,https://pubmed.ncbi.nlm.nih.gov/31514295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,36910333,Identification and Validation of a Necroptosis-Related Prognostic Signature for Kidney Renal Clear Cell Carcinoma.,2023,10.1155/2023/8446765,https://pubmed.ncbi.nlm.nih.gov/36910333/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,22621904,Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa.,2012,10.1091/mbc.e11-12-1025,https://pubmed.ncbi.nlm.nih.gov/22621904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,25937952,Construction and Analysis of the Cell Surface's Protein Network for Human Sperm-Egg Interaction.,2013,10.1155/2013/962760,https://pubmed.ncbi.nlm.nih.gov/25937952/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,25873482,Quantitative Proteomics of Human Fibroblasts with I1061T Mutation in Niemann-Pick C1 (NPC1) Protein Provides Insights into the Disease Pathogenesis.,2015,10.1074/mcp.m114.045609,https://pubmed.ncbi.nlm.nih.gov/25873482/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLGN,ENSG00000153132,Unsafe,9434179,Cloning and characterization of the human Calmegin gene encoding putative testis-specific chaperone.,1997,10.1016/s0378-1119(97)00537-4,https://pubmed.ncbi.nlm.nih.gov/9434179/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLHC1,ENSG00000162994,Unsafe,34938738,Lnc-C2orf63-4-1 Confers VSMC Homeostasis and Prevents Aortic Dissection Formation via STAT3 Interaction.,2021,10.3389/fcell.2021.792051,https://pubmed.ncbi.nlm.nih.gov/34938738/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLHC1,ENSG00000162994,Unsafe,35446297,Effective treatment in lung adenocarcinoma patient with brain metastases harboring novel CLHC1/RNT4 intergenic region- ALK fusion: A case report.,2022,10.1097/md.0000000000029134,https://pubmed.ncbi.nlm.nih.gov/35446297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLHC1,ENSG00000162994,Unsafe,36983731,High-Throughput Sequencing Reveals That Rotundine Inhibits Colorectal Cancer by Regulating Prognosis-Related Genes.,2023,10.3390/jpm13030550,https://pubmed.ncbi.nlm.nih.gov/36983731/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLHC1,ENSG00000162994,Unsafe,31842489,Somatic Mutation of PIK3CA (H1047R) Is a Common Driver Mutation Hotspot in Canine Mammary Tumors as Well as Human Breast Cancers.,2019,10.3390/cancers11122006,https://pubmed.ncbi.nlm.nih.gov/31842489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLHC1,ENSG00000162994,Unsafe,32379818,Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose.,2020,10.1371/journal.pone.0230815,https://pubmed.ncbi.nlm.nih.gov/32379818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLHC1,ENSG00000162994,Unsafe,34680890,Genome-Wide Association Studies for Milk Somatic Cell Score in Romanian Dairy Cattle.,2021,10.3390/genes12101495,https://pubmed.ncbi.nlm.nih.gov/34680890/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLHC1,ENSG00000162994,Unsafe,25558065,Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families.,2015,10.1016/j.celrep.2014.12.015,https://pubmed.ncbi.nlm.nih.gov/25558065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLIP3,ENSG00000105270,Unsafe,38756701,Quercetin through miR-147-5p/Clip3 axis reducing Th17 cell differentiation to alleviate periodontitis.,2024,10.1016/j.reth.2024.04.016,https://pubmed.ncbi.nlm.nih.gov/38756701/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLIP3,ENSG00000105270,Unsafe,34488821,Downregulated CLIP3 induces radioresistance by enhancing stemness and glycolytic flux in glioblastoma.,2021,10.1186/s13046-021-02077-4,https://pubmed.ncbi.nlm.nih.gov/34488821/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLIP3,ENSG00000105270,Unsafe,39748436,Unraveling the causal impact of smoking and its DNA methylation signatures on cardiovascular disease: Mendelian randomization and colocalization analysis.,2025,10.1186/s13148-024-01808-6,https://pubmed.ncbi.nlm.nih.gov/39748436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLIP3,ENSG00000105270,Unsafe,37088945,Carbon Dots from &lt;i&gt;Lycium barbarum&lt;/i&gt; Attenuate Radiation-Induced Bone Injury by Inhibiting Senescence via METTL3/Clip3 in an m&lt;sup&gt;6&lt;/sup&gt;A-Dependent Manner.,2023,10.1021/acsami.3c01322,https://pubmed.ncbi.nlm.nih.gov/37088945/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLIP3,ENSG00000105270,Unsafe,39885324,Integrating multiomics analysis and machine learning to refine the molecular subtyping and prognostic analysis of stomach adenocarcinoma.,2025,10.1038/s41598-025-87444-3,https://pubmed.ncbi.nlm.nih.gov/39885324/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLIP3,ENSG00000105270,Unsafe,32082184,Clip-Domain Serine Protease Gene (LsCLIP3) Is Essential for Larval-Pupal Molting and Immunity in Lasioderma serricorne.,2019,10.3389/fphys.2019.01631,https://pubmed.ncbi.nlm.nih.gov/32082184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLIP3,ENSG00000105270,Unsafe,33684100,miRNA-mediated loss of m6A increases nascent translation in glioblastoma.,2021,10.1371/journal.pgen.1009086,https://pubmed.ncbi.nlm.nih.gov/33684100/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLIP3,ENSG00000105270,Unsafe,29218499,Effect of CLIP3 Upregulation on Astrocyte Proliferation and Subsequent Glial Scar Formation in the Rat Spinal Cord via STAT3 Pathway After Injury.,2018,10.1007/s12031-017-0998-6,https://pubmed.ncbi.nlm.nih.gov/29218499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLIP3,ENSG00000105270,Unsafe,27613819,MicroRNA-593-3p regulates insulin-promoted glucose consumption by targeting Slc38a1 and CLIP3.,2016,10.1530/jme-16-0090,https://pubmed.ncbi.nlm.nih.gov/27613819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLIP3,ENSG00000105270,Unsafe,30632432,C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception.,2019,10.1177/1744806918825046,https://pubmed.ncbi.nlm.nih.gov/30632432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLIP3,ENSG00000105270,Unsafe,23014974,Changes in CLIP3 expression after sciatic nerve injury in adult rats.,2012,10.1007/s10735-012-9450-y,https://pubmed.ncbi.nlm.nih.gov/23014974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLIP3,ENSG00000105270,Unsafe,30838020,Genome-Wide Association Study for Milk Protein Composition Traits in a Chinese Holstein Population Using a Single-Step Approach.,2019,10.3389/fgene.2019.00072,https://pubmed.ncbi.nlm.nih.gov/30838020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42505461,"Universal, Rapid, and Cleavable Labeling of Antibodies by Fluorophores and DNA Oligonucleotides for Multiplex Immunostaining and Spatial Proteomics Through MIST Linker.",2026,10.3390/bios16070385,https://pubmed.ncbi.nlm.nih.gov/42505461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42771994,Age-related changes of FCGR3A&lt;sup&gt;+&lt;/sup&gt; natural killer cells and their association with elderly atopic dermatitis.,2026,10.1016/j.ebiom.2026.106489,https://pubmed.ncbi.nlm.nih.gov/42771994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,41191156,Downregulation of miRNA-133a and miRNA-452 associated with upregulation of CLNK and LEF1 genes in chronic lymphocytic leukemia: in vitro and in silico insights.,2025,10.1007/s11033-025-11203-w,https://pubmed.ncbi.nlm.nih.gov/41191156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,41820383,mist: a hierarchical Bayesian framework for detecting differential DNA methylation dynamics in single-cell data.,2026,10.1038/s41467-026-70523-y,https://pubmed.ncbi.nlm.nih.gov/41820383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42495322,Synergistic Profiling of Programmed Cell Death and Immune Responses Identifies a Novel Prognostic Index for Cervical Cancer.,2026,10.1021/acsomega.6c00858,https://pubmed.ncbi.nlm.nih.gov/42495322/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42793178,Beyond Recanalization: Neurovascular Unit Protection and Precision Adjunctive Therapy for Ischemic Stroke in the Reperfusion Era.,2026,10.3390/biom16091346,https://pubmed.ncbi.nlm.nih.gov/42793178/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42603950,Capturing the multimodal dynamics of acute stress responses: Evidence from the Montreal Imaging Stress Task (MIST).,2026,10.1016/j.ijchp.2026.100713,https://pubmed.ncbi.nlm.nih.gov/42603950/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42215273,"Mitomycin C-based angio-regression for corneal neovascularisation: outcomes with intravascular (MICE), intrastromal (MIST) and combined delivery routes.",2026,10.1136/bjo-2026-329997,https://pubmed.ncbi.nlm.nih.gov/42215273/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42433105,"Clinical, Radiographic and Patient-Centred Outcomes of MINST Versus MIST With Enamel Matrix Derivative in Class II Mandibular Furcation Defects: A Randomised Controlled Trial.",2026,10.1111/jcpe.70167,https://pubmed.ncbi.nlm.nih.gov/42433105/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,41893517,Protein Modifications and Metabolic Alterations in the Rat Striatum Following Oil Mist Particulate Matter Exposure Revealed via Untargeted Metabolomics and Phosphoproteomics.,2026,10.3390/toxics14030249,https://pubmed.ncbi.nlm.nih.gov/41893517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42522415,Vitamins A- and C-augmented platelet-rich fibrin in periodontal intraosseous defects: A randomized clinical trial.,2026,10.1002/jper.70173,https://pubmed.ncbi.nlm.nih.gov/42522415/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42208825,The effect of spray properties and inspiratory flow rate on regional nasal deposition for pressure-swirl versus soft mist devices.,2026,10.1016/j.ijpharm.2026.126991,https://pubmed.ncbi.nlm.nih.gov/42208825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42335319,Near-Armchair-Enriched Growth of Single-Walled Carbon Nanotubes via W-Containing Fe-Based Catalyst Systems in Mist FC-CVD.,2026,10.1002/smll.74316,https://pubmed.ncbi.nlm.nih.gov/42335319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42024624,Measurement Properties of the Modified Incremental Step Test for Assessing Exercise Capacity in Individuals With Type 2 Diabetes.,2026,10.1002/pri.70224,https://pubmed.ncbi.nlm.nih.gov/42024624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42181423,Extended Intrapleural Tissue Plasminogen Activator (tPA)-Dornase Alfa (DNase) Therapy Beyond the Standard Multicenter Intrapleural Sepsis Trial 2 (MIST-2) Regimen in a High-Risk Patient With Complex Empyema: A Case Report.,2026,10.7759/cureus.107447,https://pubmed.ncbi.nlm.nih.gov/42181423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,41820633,Association of neural responses to acute psychosocial stress with relapse in depression.,2026,10.1007/s11682-026-01074-5,https://pubmed.ncbi.nlm.nih.gov/41820633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42469263,Thermal management of prismatic lithium-ion battery using mist cooling with single and multiple injections: a numerical study.,2026,10.1038/s41598-026-54239-z,https://pubmed.ncbi.nlm.nih.gov/42469263/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,41760943,"Management of clinical failure after minimally invasive surgical therapies (MIST) for BPH: repeat MIST versus resection, enucleation or ablation-a narrative review from EAU endourology.",2026,10.1007/s00345-026-06300-9,https://pubmed.ncbi.nlm.nih.gov/41760943/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,41927794,Numerical study on mist-assisted film cooling performance under supersonic condition with discrete coolant injection.,2026,10.1038/s41598-026-46042-7,https://pubmed.ncbi.nlm.nih.gov/41927794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,41134685,Characterization and classification of chronic kidney disease by spatial MIST and deep learning algorithm.,2025,10.1152/ajprenal.00265.2025,https://pubmed.ncbi.nlm.nih.gov/41134685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42610046,Lidocaine Delivery Systems for Preventing Postoperative Sore Throat: From Direct Spray to Soft Mist.,2026,10.2147/lra.s627037,https://pubmed.ncbi.nlm.nih.gov/42610046/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,41710582,Inhalation: A Smart Strategy and Increasing Potential for Drug Delivery.,2026,10.2147/dddt.s575392,https://pubmed.ncbi.nlm.nih.gov/41710582/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42702566,Minimally invasive surgical therapies (MIST) for benign prostatic hyperplasia: Initial single-center experience.,2026,10.1177/03915603261486074,https://pubmed.ncbi.nlm.nih.gov/42702566/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42802595,The MIST Trial: Five Take-Home Points.,2026,10.1177/15569845261481829,https://pubmed.ncbi.nlm.nih.gov/42802595/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42648186,Key exposure components and oxidative stress-driven health risks assessment of oil mist generated by metalworking fluids in industrial building environment.,2026,10.1016/j.jhazmat.2026.143387,https://pubmed.ncbi.nlm.nih.gov/42648186/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42858986,Mist spraying vs. immersion of riboflavin for blue light-mediated photodynamic inactivation of Escherichia coli O157:H7.,2026,10.1016/j.foodres.2026.120466,https://pubmed.ncbi.nlm.nih.gov/42858986/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42876349,"Effectiveness of Surfactant Administration in Two Different Methods (MIST, INSURE) on the Short-Term Outcome of Preterm Infants With Respiratory Distress Syndrome: A Randomized Clinical Trial.",2026,10.1002/ppul.71874,https://pubmed.ncbi.nlm.nih.gov/42876349/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42624138,Beyond the incision: the MIST trial redefines contemporary coronary surgery.,2026,10.1016/s0140-6736(26)01598-9,https://pubmed.ncbi.nlm.nih.gov/42624138/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42166724,Horizon Scanning for Medical Technologies: Methodological Framework Development Study of the Medical Innovation Scanning Techniques (MIST) Framework.,2026,10.2196/93166,https://pubmed.ncbi.nlm.nih.gov/42166724/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42059970,Management of lower urinary tract symptoms before prostate cancer radiotherapy: a call for innovative strategies.,2026,10.1007/s00345-026-06427-9,https://pubmed.ncbi.nlm.nih.gov/42059970/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42923349,"Less Invasive Surfactant Administration Compared With Intubation-Surfactant-Extubation (INSURE), Nebulised Surfactant, and Continuous Positive Airway Pressure (CPAP) Alone in Preterm Infants With Respiratory Distress Syndrome: A Systematic Review. ",2026,10.7759/cureus.116702,https://pubmed.ncbi.nlm.nih.gov/42923349/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42661802,Ozone-based interventions to mitigate &lt;i&gt;Pseudomonas paracarnis&lt;/i&gt;-induced blue discoloration in fresh cheese.,2026,10.1007/s10068-026-02237-2,https://pubmed.ncbi.nlm.nih.gov/42661802/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLNK,ENSG00000109684,Unsafe,42537680,"Multivessel coronary artery bypass grafting via small thoracotomy versus sternotomy (MIST): an investigator-initiated, international, open-label, randomised controlled trial.",2026,10.1016/s0140-6736(26)01288-2,https://pubmed.ncbi.nlm.nih.gov/42537680/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,42849585,Immune responses in the olfactory organ and brain of Atlantic cod (Gadus morhua) following nasal vaccination against Francisella noatunensis.,2026,10.1016/j.fsi.2026.111767,https://pubmed.ncbi.nlm.nih.gov/42849585/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,41424860,Neuronal mitochondrial disaggregase CLPB ameliorates Huntington's disease pathology in mice.,2026,10.7150/thno.122651,https://pubmed.ncbi.nlm.nih.gov/41424860/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,42442569,The AAA+ chaperone ClpB contributes to stress tolerance and pathogenesis in Mycoplasma bovis.,2026,10.1016/j.ijbiomac.2026.153506,https://pubmed.ncbi.nlm.nih.gov/42442569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,41425934,ClpB affects biofilm formation in methicillin-resistant &lt;i&gt;Staphylococcus aureus&lt;/i&gt;.,2025,10.3389/fmicb.2025.1723924,https://pubmed.ncbi.nlm.nih.gov/41425934/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,41298523,Targeted proteomics reveal α-MSH-like Enterobacterial ClpB protein in gut microbiota of patients with anorexia nervosa.,2025,10.1038/s41522-025-00850-3,https://pubmed.ncbi.nlm.nih.gov/41298523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,42736349,Gut single-microbe landscape in patients with major depressive disorder and bipolar disorder.,2026,10.1038/s41380-026-03882-z,https://pubmed.ncbi.nlm.nih.gov/42736349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,42420651,Hypoxia rescues complex 1-associated disease caused by proteostatic defects.,2026,10.1038/s42255-026-01566-0,https://pubmed.ncbi.nlm.nih.gov/42420651/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,40194906,"CLPB Deficiency, a Mitochondrial Chaperonopathy With Neutropenia and Neurological Presentation.",2025,10.1002/jimd.70025,https://pubmed.ncbi.nlm.nih.gov/40194906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,42353783,The Roles of Molecular Chaperones Interacting with the σ&lt;sup&gt;70&lt;/sup&gt; Factor in Global Transcription of the &lt;i&gt;Escherichia coli&lt;/i&gt; Genome.,2026,10.3390/genes17060621,https://pubmed.ncbi.nlm.nih.gov/42353783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,41135667,Immunization reveals a key role of Enterobacterial ClpB protein in the development of host anorexia.,2026,10.1016/j.bbi.2025.106152,https://pubmed.ncbi.nlm.nih.gov/41135667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,40036943,Enterobacterial caseinolytic protease B (ClpB) and ClpB antibodies in adolescents with anorexia nervosa.,2025,10.1016/j.jpsychires.2025.02.034,https://pubmed.ncbi.nlm.nih.gov/40036943/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,37041140,Structural basis of impaired disaggregase function in the oxidation-sensitive SKD3 mutant causing 3-methylglutaconic aciduria.,2023,10.1038/s41467-023-37657-9,https://pubmed.ncbi.nlm.nih.gov/37041140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,41560087,CLPB deficiency-associated congenital neutropenia: A rare case report and literature review.,2026,10.1097/md.0000000000046987,https://pubmed.ncbi.nlm.nih.gov/41560087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,41719910,From genotype to outcome: Zygosity-specific insights in 63 cases of CLPB-related mitochondrial disease.,2026,10.1016/j.ymgme.2026.109752,https://pubmed.ncbi.nlm.nih.gov/41719910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,40286845,CircPAFAH1B2 induces chondrocytes mitochondrial dysfunction and promotes cartilage degeneration through binding molecular chaperone ClpB.,2025,10.1016/j.jare.2025.04.024,https://pubmed.ncbi.nlm.nih.gov/40286845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,40118824,"Dependence of mitochondrial calcium signalling and dynamics on the disaggregase, CLPB.",2025,10.1038/s41467-025-57641-9,https://pubmed.ncbi.nlm.nih.gov/40118824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,35247700,Human mitochondrial AAA+ ATPase SKD3/CLPB assembles into nucleotide-stabilized dodecamers.,2022,10.1016/j.bbrc.2022.02.101,https://pubmed.ncbi.nlm.nih.gov/35247700/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,41565662,A stochastic mechanism drives fast substrate translocation in the AAA+ machine ClpB.,2026,10.1038/s41467-026-68478-1,https://pubmed.ncbi.nlm.nih.gov/41565662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,36745679,Comprehensive structural characterization of the human AAA+ disaggregase CLPB in the apo- and substrate-bound states reveals a unique mode of action driven by oligomerization.,2023,10.1371/journal.pbio.3001987,https://pubmed.ncbi.nlm.nih.gov/36745679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,42737659,Comparative Characterization of σ&lt;sup&gt;32&lt;/sup&gt;-Dependent Promoters for the Heat-Inducible Expression of FAST-PETase in &lt;i&gt;Escherichia coli&lt;/i&gt;.,2026,10.3390/ijms27177762,https://pubmed.ncbi.nlm.nih.gov/42737659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,40322557,Evaluation of Immunostimulatory Effects of Bacterial Lysate Proteins on THP-1 Macrophages: Pro-inflammatory Cytokine Response and Proteomic Profiling.,2025,10.1155/jimr/2289241,https://pubmed.ncbi.nlm.nih.gov/40322557/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,40304467,ClpB enhances thermotolerance in &lt;i&gt;Campylobacter jejuni&lt;/i&gt; through protein disaggregation independent of DnaK.,2025,10.1128/spectrum.02293-24,https://pubmed.ncbi.nlm.nih.gov/40304467/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,38339390,The Interplay between Heat Shock Proteins and Cancer Pathogenesis: A Novel Strategy for Cancer Therapeutics.,2024,10.3390/cancers16030638,https://pubmed.ncbi.nlm.nih.gov/38339390/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,42238763,Growth on corn salad leaves and polystyrene as well as the temperature influence the transcriptome of &lt;i&gt;Listeria monocytogenes&lt;/i&gt; NCTC 10887.,2026,10.1016/j.crfs.2026.101450,https://pubmed.ncbi.nlm.nih.gov/42238763/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,41265506,Co-expression network insights into Leptospira interrogans pathogenesis.,2025,10.1016/j.resmic.2025.104352,https://pubmed.ncbi.nlm.nih.gov/41265506/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,37955686,Integrative lactylation and tumor microenvironment signature as prognostic and therapeutic biomarkers in skin cutaneous melanoma.,2023,10.1007/s00432-023-05483-7,https://pubmed.ncbi.nlm.nih.gov/37955686/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,40367773,Disrupting cross-adaptation in high-risk MRSA: Sanguinarine as a multi-effective stress sensitizer for environmental and food safety.,2025,10.1016/j.jhazmat.2025.138586,https://pubmed.ncbi.nlm.nih.gov/40367773/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,41722985,Modelling gene-dependent PEF resistance of E. coli K-12.,2026,10.1016/j.fm.2026.105042,https://pubmed.ncbi.nlm.nih.gov/41722985/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,41784695,Phage Henu15-resistant mutant derives fitness trade-offs in Morganella morganii.,2026,10.1186/s13568-026-02032-6,https://pubmed.ncbi.nlm.nih.gov/41784695/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,40548722,"Isolation, identification, and pathogenicity of &lt;i&gt;Pseudoalteromonas aliena&lt;/i&gt; associated with oyster disease outbreaks in summer.",2025,10.1128/spectrum.00173-25,https://pubmed.ncbi.nlm.nih.gov/40548722/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,41575849,Stress testing reveals selective vulnerabilities in protein homeostasis.,2026,10.1016/j.celrep.2025.116892,https://pubmed.ncbi.nlm.nih.gov/41575849/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,42393339,Paradoxical non-catalytic kinase functions are driven by inhibitor-induced displacement of autoinhibitory domains.,2026,10.1038/s44320-026-00229-2,https://pubmed.ncbi.nlm.nih.gov/42393339/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,40909968,Developing a prognostic model of glutamine metabolism-related genes associated with clinical features and immune status in melanoma.,2025,10.3389/fonc.2025.1485006,https://pubmed.ncbi.nlm.nih.gov/40909968/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,38598269,The Listeria monocytogenes persistence factor ClpL is a potent stand-alone disaggregase.,2024,10.7554/elife.92746,https://pubmed.ncbi.nlm.nih.gov/38598269/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,40683719,Foodborne diarrhea outbreaks linked to Citrobacter species in East China 2022-2023.,2025,10.1016/j.fm.2025.104839,https://pubmed.ncbi.nlm.nih.gov/40683719/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,40034257,"Identification and assessment of hub genes and miRNAs coregulatory associated with immune infiltrations and drug interactions in latent tuberculosis based on MicroarrayData analysis, molecular docking, and dynamic simulation.",2025,10.1016/j.bbrep.2025.101952,https://pubmed.ncbi.nlm.nih.gov/40034257/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,25597511,"CLPB variants associated with autosomal-recessive mitochondrial disorder with cataract, neutropenia, epilepsy, and methylglutaconic aciduria.",2015,10.1016/j.ajhg.2014.12.020,https://pubmed.ncbi.nlm.nih.gov/25597511/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPB,ENSG00000162129,Unsafe,25597510,"CLPB mutations cause 3-methylglutaconic aciduria, progressive brain atrophy, intellectual disability, congenital neutropenia, cataracts, movement disorder.",2015,10.1016/j.ajhg.2014.12.013,https://pubmed.ncbi.nlm.nih.gov/25597510/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPSL1,ENSG00000204140,Unsafe,32127941,A Combined four-mRNA Signature Associated with Lymphatic Metastasis for Prognosis of Colorectal Cancer.,2020,10.7150/jca.38796,https://pubmed.ncbi.nlm.nih.gov/32127941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPSL1,ENSG00000204140,Unsafe,18390568,Transcriptome analysis of a cDNA library from adult human epididymis.,2008,10.1093/dnares/dsn005,https://pubmed.ncbi.nlm.nih.gov/18390568/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPSL2,ENSG00000196748,Unsafe,41039546,Elucidating the pathogenesis of rumen abnormal adipose deposition in high-concentrate fed Hu sheep through transcriptomic profiling.,2025,10.1186/s12917-025-04988-2,https://pubmed.ncbi.nlm.nih.gov/41039546/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPSL2,ENSG00000196748,Unsafe,30927342,Nine genes abundantly expressed in the epididymis are not essential for male fecundity in mice.,2019,10.1111/andr.12621,https://pubmed.ncbi.nlm.nih.gov/30927342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPSL2,ENSG00000196748,Unsafe,29323738,"An epididymis-specific secretory protein Clpsl2 critically regulates sperm motility, acrosomal integrity, and male fertility.",2018,10.1002/jcb.26668,https://pubmed.ncbi.nlm.nih.gov/29323738/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPSL2,ENSG00000196748,Unsafe,32444848,"Prediction of breast cancer proteins involved in immunotherapy, metastasis, and RNA-binding using molecular descriptors and artificial neural networks.",2020,10.1038/s41598-020-65584-y,https://pubmed.ncbi.nlm.nih.gov/32444848/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLPSL2,ENSG00000196748,Unsafe,30744329,Selection signature reveals genes associated with susceptibility loci affecting respiratory disease due to pleiotropic and hitchhiking effect in Chinese indigenous pigs.,2020,10.5713/ajas.18.0658,https://pubmed.ncbi.nlm.nih.gov/30744329/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,42545893,CLRN1 Variants in Müller Cells Cause Mitochondrial Dysfunction in USH3A Retinal Organoids.,2026,10.1002/cns.71068,https://pubmed.ncbi.nlm.nih.gov/42545893/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,42390169,Müller Glia-Exclusive CLRN1 Expression Drives Non-Cell-Autonomous Photoreceptor Degeneration in Usher Syndrome Type 3A.,2026,10.1167/iovs.67.8.9,https://pubmed.ncbi.nlm.nih.gov/42390169/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,40067805,The USH3A causative gene clarin1 functions in Müller glia to maintain retinal photoreceptors.,2025,10.1371/journal.pgen.1011205,https://pubmed.ncbi.nlm.nih.gov/40067805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,39304915,A rare transcript homozygous variants in CLRN1(USH3A) causes Usher syndrome type 3 in a Chinese family.,2024,10.1186/s13023-024-03348-x,https://pubmed.ncbi.nlm.nih.gov/39304915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,42349043,Clarin-1 mRNA expression in the central auditory system of Fischer Brown Norway rats.,2026,10.1016/j.heares.2026.109713,https://pubmed.ncbi.nlm.nih.gov/42349043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,41572507,Compensatory Interplay Between Clarin-1 and Clarin-2 Deafness-Associated Proteins Governs Phenotypic Variability in Hearing.,2026,10.1002/advs.202521853,https://pubmed.ncbi.nlm.nih.gov/41572507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,42133691,Implanted injection port for routine drug delivery to the middle ear in mice.,2026,10.1371/journal.pone.0349097,https://pubmed.ncbi.nlm.nih.gov/42133691/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,41430327,Genes linked to hearing and vestibular phenotypes in humans and mice: an interspecies systematic review.,2025,10.1186/s40246-025-00891-x,https://pubmed.ncbi.nlm.nih.gov/41430327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,40527252,Exosomal CLRN1-AS1 restrains hepatocellular carcinoma cell proliferation and migration via targeting miR-320c/SRSF7 signaling by using cellular thermal and medical thermal imaging.,2025,10.1016/j.jtherbio.2025.104174,https://pubmed.ncbi.nlm.nih.gov/40527252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,39596563,A Leaky Deep Intronic Splice Variant in &lt;i&gt;CLRN1&lt;/i&gt; Is Associated with Non-Syndromic Retinitis Pigmentosa.,2024,10.3390/genes15111363,https://pubmed.ncbi.nlm.nih.gov/39596563/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,41405758,Identification of novel ceRNA networks associated with system hemostasis and their prognostic implication in lung squamous cell carcinoma.,2026,10.1007/s11239-025-03218-8,https://pubmed.ncbi.nlm.nih.gov/41405758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,32841912,Antisense Oligonucleotide- and CRISPR-Cas9-Mediated Rescue of mRNA Splicing for a Deep Intronic CLRN1 Mutation.,2020,10.1016/j.omtn.2020.07.036,https://pubmed.ncbi.nlm.nih.gov/32841912/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,37531749,lncRNA CLRN1-AS1 reduces adhesion ability of human trophoblasts via CXCL10/CXCL11.,2023,10.1016/j.placenta.2023.07.003,https://pubmed.ncbi.nlm.nih.gov/37531749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,31625146,Clarin-1 expression in adult mouse and human retina highlights a role of Müller glia in Usher syndrome.,2020,10.1002/path.5360,https://pubmed.ncbi.nlm.nih.gov/31625146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,31097578,Unconventional secretory pathway activation restores hair cell mechanotransduction in an USH3A model.,2019,10.1073/pnas.1817500116,https://pubmed.ncbi.nlm.nih.gov/31097578/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,41060164,Identification of a variant in the USH1G gene in a family with Usher syndrome,2025,10.7705/biomedica.7498,https://pubmed.ncbi.nlm.nih.gov/41060164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,35481838,Retinal Phenotype of Patients with CLRN1-Associated Usher 3A Syndrome in French Light4Deaf Cohort.,2022,10.1167/iovs.63.4.25,https://pubmed.ncbi.nlm.nih.gov/35481838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,38204968,Interplay between lncRNA/miRNA and Wnt/ß-catenin signaling in brain cancer tumorigenesis.,2023,10.17179/excli2023-6490,https://pubmed.ncbi.nlm.nih.gov/38204968/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,29985171,Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome.,2018,10.1172/jci94351,https://pubmed.ncbi.nlm.nih.gov/29985171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,39655096,Efficiency of gene therapy for sensorineural hearing loss in mouse model: A meta-analysis.,2024,10.1002/lio2.70048,https://pubmed.ncbi.nlm.nih.gov/39655096/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,26881841,AAV-Mediated Clarin-1 Expression in the Mouse Retina: Implications for USH3A Gene Therapy.,2016,10.1371/journal.pone.0148874,https://pubmed.ncbi.nlm.nih.gov/26881841/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,39051374,Differential Expression of lncRNAs in HIV Patients with TB and HIV-TB with Anti-Retroviral Treatment.,2024,10.3390/ncrna10040040,https://pubmed.ncbi.nlm.nih.gov/39051374/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,39044131,"A large-scale screening identified in USH2A gene the P3272L founder pathogenic variant explaining familial Usher syndrome in Sardinia, Italy.",2024,10.1186/s12886-024-03578-4,https://pubmed.ncbi.nlm.nih.gov/39044131/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,38706793,Dissecting the shared genetic architecture between Alzheimer's disease and frailty: a cross-trait meta-analyses of genome-wide association studies.,2024,10.3389/fgene.2024.1376050,https://pubmed.ncbi.nlm.nih.gov/38706793/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,35353227,The genetic and phenotypic landscapes of Usher syndrome: from disease mechanisms to a new classification.,2022,10.1007/s00439-022-02448-7,https://pubmed.ncbi.nlm.nih.gov/35353227/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,29545425,Unilateral retinitis pigmentosa occurring in an individual with a mutation in the CLRN1 gene.,2018,10.1136/bcr-2017-222045,https://pubmed.ncbi.nlm.nih.gov/29545425/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,33869656,AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear.,2021,10.1016/j.omtm.2021.03.019,https://pubmed.ncbi.nlm.nih.gov/33869656/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,35076463,Usher Syndrome.,2022,10.3390/audiolres12010005,https://pubmed.ncbi.nlm.nih.gov/35076463/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,30581889,Gene Transfer with AAV9-PHP.B Rescues Hearing in a Mouse Model of Usher Syndrome 3A and Transduces Hair Cells in a Non-human Primate.,2019,10.1016/j.omtm.2018.11.003,https://pubmed.ncbi.nlm.nih.gov/30581889/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,32612358,Artemisinin Loaded mPEG-PCL Nanoparticle Based Photosensitive Gelatin Methacrylate Hydrogels for the Treatment of Gentamicin Induced Hearing Loss.,2020,10.2147/ijn.s245188,https://pubmed.ncbi.nlm.nih.gov/32612358/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,22964989,Cone structure in patients with usher syndrome type III and mutations in the Clarin 1 gene.,2013,10.1001/2013.jamaophthalmol.2,https://pubmed.ncbi.nlm.nih.gov/22964989/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,30679912,Comprehensive analysis of potential prognostic genes for the construction of a competing endogenous RNA regulatory network in hepatocellular carcinoma.,2019,10.2147/ott.s188913,https://pubmed.ncbi.nlm.nih.gov/30679912/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLRN1,ENSG00000163646,Unsafe,21234346,An update on the genetics of usher syndrome.,2011,10.1155/2011/417217,https://pubmed.ncbi.nlm.nih.gov/21234346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,42823159,CLSPN Is Expressed in Pancreatic Cancer and Can Be a Target for Immunotherapy.,2026,10.21873/anticanres.18384,https://pubmed.ncbi.nlm.nih.gov/42823159/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,41656416,Integrating multi-omics analysis identifies DNA damage-related gene CLSPN as a biomarker in gastric cancer.,2026,10.1038/s41598-026-39387-6,https://pubmed.ncbi.nlm.nih.gov/41656416/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,41069850,ALKBH5-IGF2BP2 axis mediates prostate cancer progression and docetaxel resistance via m6A-stabilized CLSPN RNA.,2025,10.1016/j.isci.2025.113520,https://pubmed.ncbi.nlm.nih.gov/41069850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,40275302,Potential of CLSPN as a therapeutic target in melanoma: a key player in melanoma progression and tumor microenvironment.,2025,10.1186/s12967-025-06455-w,https://pubmed.ncbi.nlm.nih.gov/40275302/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,42811518,Dual CHK1 and WNT Inhibition as a Synergistic Therapy for Gastrointestinal Neuroendocrine Carcinoma.,2026,10.1158/2767-9764.crc-26-0351,https://pubmed.ncbi.nlm.nih.gov/42811518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,41009395,Claspin and Cancer: Where Are We Now?,2025,10.3390/ijms26188828,https://pubmed.ncbi.nlm.nih.gov/41009395/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,39539024,"Establishment of potent TCR-T cells specific for cisplatin-resistance related tumor-associated antigen, CLSPN using codon-optimization.",2024,10.1080/21645515.2024.2414542,https://pubmed.ncbi.nlm.nih.gov/39539024/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,40723231,MicroRNA Signatures in Lung Adenocarcinoma Metastases: Exploring the Oncogenic Targets of Tumor-Suppressive &lt;i&gt;miR-195-5p&lt;/i&gt; and &lt;i&gt;miR-195-3p&lt;/i&gt;.,2025,10.3390/cancers17142348,https://pubmed.ncbi.nlm.nih.gov/40723231/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,41083899,Transcriptome profiling of human dermal MDPL fibroblasts reveals a characteristic molecular signature providing insights into pathogenic mechanisms.,2025,10.1007/s00109-025-02597-y,https://pubmed.ncbi.nlm.nih.gov/41083899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,40594722,CRISPR-Cas9 screening identifies a gene signature predictive of prognosis in glioblastoma.,2025,10.1038/s41598-025-07815-8,https://pubmed.ncbi.nlm.nih.gov/40594722/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,38492457,How CLSPN could demystify its prognostic value and potential molecular mechanism for hepatocellular carcinoma: A crosstalk study.,2024,10.1016/j.compbiomed.2024.108260,https://pubmed.ncbi.nlm.nih.gov/38492457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,37268895,"A multi-omics analysis reveals CLSPN is associated with prognosis, immune microenvironment and drug resistance in cancers.",2023,10.1186/s12575-023-00201-6,https://pubmed.ncbi.nlm.nih.gov/37268895/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,38256171,The Interaction between CLSPN Gene Polymorphisms and Alcohol Consumption Contributes to Oral Cancer Progression.,2024,10.3390/ijms25021098,https://pubmed.ncbi.nlm.nih.gov/38256171/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,40423834,Prognostic implication of six m6A-modulated genes signature in the ferroptosis for hepatocellular carcinoma patients.,2025,10.1007/s10238-025-01700-4,https://pubmed.ncbi.nlm.nih.gov/40423834/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,40936337,Identifying Gene Predictors of Chemicals Linked With Breast Cancer: A Machine Learning Analysis of MCF7 Cellular Transcriptomic Screening Data.,2025,10.1002/em.70034,https://pubmed.ncbi.nlm.nih.gov/40936337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,38237848,CLSPN actives Wnt/β-catenin signaling to facilitate glycolysis and cell proliferation in oral squamous cell carcinoma.,2024,10.1016/j.yexcr.2024.113935,https://pubmed.ncbi.nlm.nih.gov/38237848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,42895160,Persistent Cognitive Vulnerability After COVID-19 in Older Adults: Longitudinal Clinical Trajectories and Multi-Cohort Transcriptomic Evidence.,2026,10.2174/0118746098486923261008032626,https://pubmed.ncbi.nlm.nih.gov/42895160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,36795123,Cisplatin resistance driver claspin is a target for immunotherapy in urothelial carcinoma.,2023,10.1007/s00262-023-03388-5,https://pubmed.ncbi.nlm.nih.gov/36795123/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,39095857,Analysis of miR-497/195 cluster identifies new therapeutic targets in cervical cancer.,2024,10.1186/s13104-024-06876-8,https://pubmed.ncbi.nlm.nih.gov/39095857/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,36240068,"Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential.",2022,10.1042/bcj20220101,https://pubmed.ncbi.nlm.nih.gov/36240068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,35487167,CLSPN is a potential biomarker associated with poor prognosis in low-grade gliomas based on a multi-database analysis.,2022,10.1016/j.retram.2022.103345,https://pubmed.ncbi.nlm.nih.gov/35487167/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,41424711,Exosome and BCR-ABL mediated molecular alterations in endothelial cells in chronic myeloid leukemia: identification of seven genes and their regulatory network.,2025,10.7717/peerj.20371,https://pubmed.ncbi.nlm.nih.gov/41424711/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,39066192,A T-Cell-Derived 3-Gene Signature Distinguishes SARS-CoV-2 from Common Respiratory Viruses.,2024,10.3390/v16071029,https://pubmed.ncbi.nlm.nih.gov/39066192/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,37542549,Comprehensive analysis of CPSF4-related alternative splice genes in hepatocellular carcinoma.,2023,10.1007/s00432-023-05178-z,https://pubmed.ncbi.nlm.nih.gov/37542549/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,34093635,Identification of Prognostic Biomarkers and Correlation With Immune Infiltrates in Hepatocellular Carcinoma Based on a Competing Endogenous RNA Network.,2021,10.3389/fgene.2021.591623,https://pubmed.ncbi.nlm.nih.gov/34093635/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,37485814,Actionable loss of SLF2 drives B-cell lymphomagenesis and impairs the DNA damage response.,2023,10.15252/emmm.202216431,https://pubmed.ncbi.nlm.nih.gov/37485814/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLSPN,ENSG00000092853,Unsafe,37176052,Splicing Characterization and Isoform Switch Events in Human Keratinocytes Carrying Oncogenes from High-Risk HPV-16 and Low-Risk HPV-84.,2023,10.3390/ijms24098347,https://pubmed.ncbi.nlm.nih.gov/37176052/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLUL1,ENSG00000079101,Unsafe,36788507,Maternal circulating metabolic biomarkers and their prediction performance for gestational diabetes mellitus related macrosomia.,2023,10.1186/s12884-023-05440-9,https://pubmed.ncbi.nlm.nih.gov/36788507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLUL1,ENSG00000079101,Unsafe,37239365,CRISPR/Cas9-Mediated Knockout of tnfaip1 in Zebrafish Plays a Role in Early Development.,2023,10.3390/genes14051005,https://pubmed.ncbi.nlm.nih.gov/37239365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLUL1,ENSG00000079101,Unsafe,34383793,Peptide barcodes in dogs affected by mitral valve disease with and without pulmonary hypertension using MALDI-TOF MS and LC-MS/MS.,2021,10.1371/journal.pone.0255611,https://pubmed.ncbi.nlm.nih.gov/34383793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLUL1,ENSG00000079101,Unsafe,32509443,Bioinformatics analyses of retinoblastoma reveal the retinoblastoma progression subtypes.,2020,10.7717/peerj.8873,https://pubmed.ncbi.nlm.nih.gov/32509443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLUL1,ENSG00000079101,Unsafe,32277175,Genome-wide meta-analysis identifies novel loci associated with age-related macular degeneration.,2020,10.1038/s10038-020-0750-x,https://pubmed.ncbi.nlm.nih.gov/32277175/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLUL1,ENSG00000079101,Unsafe,29529059,Investigating the modulation of genetic effects on late AMD by age and sex: Lessons learned and two additional loci.,2018,10.1371/journal.pone.0194321,https://pubmed.ncbi.nlm.nih.gov/29529059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLUL1,ENSG00000079101,Unsafe,17148042,"Mutation screen of the cone-specific gene, CLUL1, in 376 patients with age-related macular degeneration.",2006,10.1080/13816810600976871,https://pubmed.ncbi.nlm.nih.gov/17148042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLUL1,ENSG00000079101,Unsafe,10675623,"Molecular cloning, characterization and expression of a novel retinal clusterin-like protein cDNA.",2000,10.1016/s0378-1119(99)00542-9,https://pubmed.ncbi.nlm.nih.gov/10675623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLUL1,ENSG00000079101,Unsafe,14507903,"Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene.",2003,10.1167/iovs.02-1202,https://pubmed.ncbi.nlm.nih.gov/14507903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLUL1,ENSG00000079101,Unsafe,15747770,Dissecting the genetics of human high myopia: a molecular biologic approach.,2004,,https://pubmed.ncbi.nlm.nih.gov/15747770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CLUL1,ENSG00000079101,Unsafe,15723005,Genomic structure and organization of the high grade Myopia-2 locus (MYP2) critical region: mutation screening of 9 positional candidate genes.,2005,,https://pubmed.ncbi.nlm.nih.gov/15723005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,42535376,Role of CMTM6 in disease pathogenesis and clinical translation potential (Review).,2026,10.3892/mmr.2026.13977,https://pubmed.ncbi.nlm.nih.gov/42535376/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,41583513,Molecular Subtyping and Prognostic Prediction in Pancreatic Cancer Based on Mitophagy-Related Genes.,2026,10.7150/ijms.121350,https://pubmed.ncbi.nlm.nih.gov/41583513/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,40179060,Comprehensive analysis of CMTM family and immune infiltration in esophageal carcinoma.,2025,10.1371/journal.pone.0321037,https://pubmed.ncbi.nlm.nih.gov/40179060/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,38223763,Research insights into the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM): their roles in various tumors.,2024,10.7717/peerj.16757,https://pubmed.ncbi.nlm.nih.gov/38223763/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,32944388,CMTM family proteins 1-8: roles in cancer biological processes and potential clinical value.,2020,10.20892/j.issn.2095-3941.2020.0032,https://pubmed.ncbi.nlm.nih.gov/32944388/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,40527380,Chemokine-like factor-like MARVEL transmembrane domain-containing 1 identified as a novel target protein for immune dysregulation in sepsis: A machine learning and molecular dynamics framework for diagnostic biomarkers and therapeutic exploration.,2025,10.1016/j.ijbiomac.2025.145276,https://pubmed.ncbi.nlm.nih.gov/40527380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,33585698,Expression and clinical significance of CMTM1 in hepatocellular carcinoma.,2021,10.1515/med-2021-0221,https://pubmed.ncbi.nlm.nih.gov/33585698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,36110202,Identification of prognostic biomarkers in the CMTM family genes of human ovarian cancer through bioinformatics analysis and experimental verification.,2022,10.3389/fgene.2022.918319,https://pubmed.ncbi.nlm.nih.gov/36110202/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,33282744,Chemokine-Like Factor-Like MARVEL Transmembrane Domain-Containing Family in Hepatocellular Carcinoma: Latest Advances.,2020,10.3389/fonc.2020.595973,https://pubmed.ncbi.nlm.nih.gov/33282744/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,37649636,Current Opinions on the Relationship Between CMTM Family and Hepatocellular Carcinoma.,2023,10.2147/jhc.s417202,https://pubmed.ncbi.nlm.nih.gov/37649636/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,34012634,Comprehensive analysis of the prognostic value of the chemokine-like factor-like MARVEL transmembrane domain-containing family in gastric cancer.,2021,10.21037/jgo-21-78,https://pubmed.ncbi.nlm.nih.gov/34012634/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,33076971,rAAV-related therapy fully rescues myonuclear and myofilament function in X-linked myotubular myopathy.,2020,10.1186/s40478-020-01048-8,https://pubmed.ncbi.nlm.nih.gov/33076971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,31754330,Research Advances in CKLF-like MARVEL Transmembrane Domain-containing Family in Non-small Cell Lung Cancer.,2019,10.7150/ijbs.33733,https://pubmed.ncbi.nlm.nih.gov/31754330/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,30209135,Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice.,2018,10.1242/jcs.221481,https://pubmed.ncbi.nlm.nih.gov/30209135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,36975415,CKLF as a Prognostic Biomarker and Its Association with Immune Infiltration in Hepatocellular Carcinoma.,2023,10.3390/curroncol30030202,https://pubmed.ncbi.nlm.nih.gov/36975415/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,32195671,Chemokine-like factor-like MARVEL transmembrane domain-containing family in autoimmune diseases.,2020,10.1097/cm9.0000000000000747,https://pubmed.ncbi.nlm.nih.gov/32195671/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,31542285,A novel protein CMTM1-v5 specifically induced human lymphoma cells apoptosis in vitro and in vivo.,2019,10.1016/j.yexcr.2019.111623,https://pubmed.ncbi.nlm.nih.gov/31542285/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,33813507,Possible effects of chemokine-like factor-like MARVEL transmembrane domain-containing family on antiphospholipid syndrome.,2021,10.1097/cm9.0000000000001449,https://pubmed.ncbi.nlm.nih.gov/33813507/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,31784415,AAV-Mediated Gene Transfer Restores a Normal Muscle Transcriptome in a Canine Model of X-Linked Myotubular Myopathy.,2020,10.1016/j.ymthe.2019.10.018,https://pubmed.ncbi.nlm.nih.gov/31784415/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,32568178,CMTM5/7 are biomarkers and prognostic factors in human breast carcinoma.,2020,10.3233/cbm-191226,https://pubmed.ncbi.nlm.nih.gov/32568178/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,41562477,Blood-Based Immunoglobulin-Bound Neoantigen Signatures Associated with MEN Type 1-Related Duodenopancreatic Neuroendocrine Tumor Progression.,2026,10.1097/xcs.0000000000001782,https://pubmed.ncbi.nlm.nih.gov/41562477/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,35303517,Sex-specific placental gene expression signatures of small for gestational age at birth.,2022,10.1016/j.placenta.2022.03.004,https://pubmed.ncbi.nlm.nih.gov/35303517/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,28237839,Systemic AAV8-Mediated Gene Therapy Drives Whole-Body Correction of Myotubular Myopathy in Dogs.,2017,10.1016/j.ymthe.2017.02.004,https://pubmed.ncbi.nlm.nih.gov/28237839/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,15147728,"Molecular cloning and characterization of chemokine-like factor super family member 1 (CKLFSF1), a novel human gene with at least 23 alternative splicing isoforms in testis tissue.",2004,10.1016/j.biocel.2003.11.017,https://pubmed.ncbi.nlm.nih.gov/15147728/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM1,ENSG00000089505,Unsafe,12782130,Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.,2003,10.1016/s0888-7543(03)00095-8,https://pubmed.ncbi.nlm.nih.gov/12782130/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,40167928,Expression Patterns and Functional Implications of CMTM2 in Human Testis and Sperm.,2025,10.1007/s43032-025-01852-4,https://pubmed.ncbi.nlm.nih.gov/40167928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,40783922,[CMTM2 is involved in spermatogenesis regulation in the testis of the mouse model of experimental autoimmune orchitis].,2024,,https://pubmed.ncbi.nlm.nih.gov/40783922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,42229831,Exploratory multi‑omics analysis for candidate biomarker identification in Parkinson's disease.,2026,10.1016/j.neuroscience.2026.05.035,https://pubmed.ncbi.nlm.nih.gov/42229831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,42862824,Integrated bioinformatics analysis identifies an immune-related gene signature associated with non-obstructive azoospermia.,2026,10.1371/journal.pone.0360305,https://pubmed.ncbi.nlm.nih.gov/42862824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,41889637,Integrated expression quantitative trait loci and Mendelian randomization analyses of the candidate genes and pathways identified for myocardial infarction.,2026,10.3389/fmolb.2026.1693113,https://pubmed.ncbi.nlm.nih.gov/41889637/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,39925932,Shared Genes and Pathways in Ulcerative Colitis and Ankylosing Spondylitis: Functional Validation and Implications for Diagnosis.,2025,10.2147/jir.s497201,https://pubmed.ncbi.nlm.nih.gov/39925932/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,35873650,Antitumor Effect of Si-Jun-Zi Decoction on SGC7901 Gastric Cancer Cells by CMTM2 Activation.,2022,10.1155/2022/4675815,https://pubmed.ncbi.nlm.nih.gov/35873650/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,33101541,Identification of Serum CMTM2 as a Potential Biomarker for HBV-Related Disorders.,2020,10.1155/2020/2032056,https://pubmed.ncbi.nlm.nih.gov/33101541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,37545529,Development of a novel immune infiltration-related diagnostic model for Alzheimer's disease using bioinformatic strategies.,2023,10.3389/fimmu.2023.1147501,https://pubmed.ncbi.nlm.nih.gov/37545529/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,37063890,Identification of immunodiagnostic blood biomarkers associated with spinal cord injury severity.,2023,10.3389/fimmu.2023.1101564,https://pubmed.ncbi.nlm.nih.gov/37063890/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,32154044,Goat CMTM2: mRNA expression profiles of different alternative spliced variants and associations analyses with growth traits.,2020,10.1007/s13205-020-2125-6,https://pubmed.ncbi.nlm.nih.gov/32154044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,30996358,[CMTM2 is involved in spermiogenesis in mice].,2019,10.19723/j.issn.1671-167x.2019.02.005,https://pubmed.ncbi.nlm.nih.gov/30996358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,32606785,Down-Regulated CMTM2 Promotes Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma.,2020,10.2147/ott.s250370,https://pubmed.ncbi.nlm.nih.gov/32606785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,34012634,Comprehensive analysis of the prognostic value of the chemokine-like factor-like MARVEL transmembrane domain-containing family in gastric cancer.,2021,10.21037/jgo-21-78,https://pubmed.ncbi.nlm.nih.gov/34012634/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,31362196,A 14-bp functional deletion within the CMTM2 gene is significantly associated with litter size in goat.,2019,10.1016/j.theriogenology.2019.07.026,https://pubmed.ncbi.nlm.nih.gov/31362196/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,28816268,[Expression and localization of transmembrane protein CMTM2 in human testis and sperm].,2017,,https://pubmed.ncbi.nlm.nih.gov/28816268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,32688456,Identification and validation of novel DNA methylation markers for early diagnosis of lung adenocarcinoma.,2020,10.1002/1878-0261.12767,https://pubmed.ncbi.nlm.nih.gov/32688456/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,32195671,Chemokine-like factor-like MARVEL transmembrane domain-containing family in autoimmune diseases.,2020,10.1097/cm9.0000000000000747,https://pubmed.ncbi.nlm.nih.gov/32195671/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,36975415,CKLF as a Prognostic Biomarker and Its Association with Immune Infiltration in Hepatocellular Carcinoma.,2023,10.3390/curroncol30030202,https://pubmed.ncbi.nlm.nih.gov/36975415/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,31990600,Downregulated CMTM2 Poses Potential Clinical Significance in Hepatocellular Carcinoma.,2020,10.1089/dna.2019.5237,https://pubmed.ncbi.nlm.nih.gov/31990600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,35246970,"A novel signature based on immune-related gene pairs and clinical features to predict prognosis and treatment effect in ""driver gene negative"" lung adenocarcinoma.",2022,10.1002/cam4.4577,https://pubmed.ncbi.nlm.nih.gov/35246970/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,33813507,Possible effects of chemokine-like factor-like MARVEL transmembrane domain-containing family on antiphospholipid syndrome.,2021,10.1097/cm9.0000000000001449,https://pubmed.ncbi.nlm.nih.gov/33813507/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,23700724,[CMTM2 antagonizes cyclophosphamide-induced reproductive toxicity and regulates StAR expression in a transgenic mouse model].,2013,,https://pubmed.ncbi.nlm.nih.gov/23700724/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CMTM2,ENSG00000140932,Unsafe,12782130,Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.,2003,10.1016/s0888-7543(03)00095-8,https://pubmed.ncbi.nlm.nih.gov/12782130/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNBD1,ENSG00000176571,Unsafe,41074960,Integrating genome-wide and epigenome-wide associations for antipsychotic induced extrapyramidal side effects.,2026,10.1007/s00213-025-06912-w,https://pubmed.ncbi.nlm.nih.gov/41074960/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNBD1,ENSG00000176571,Unsafe,36845398,Identification of three metabolic subtypes in gastric cancer and the construction of a metabolic pathway-based risk model that predicts the overall survival of GC patients.,2023,10.3389/fgene.2023.1094838,https://pubmed.ncbi.nlm.nih.gov/36845398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNBD1,ENSG00000176571,Unsafe,36100143,"In silico identification of the potential molecular mechanisms involved in protective effects of prolactin on motor and memory deficits induced by 1,2-Diacetylbenzene in young and old rats.",2022,10.1016/j.neuro.2022.09.002,https://pubmed.ncbi.nlm.nih.gov/36100143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNBD1,ENSG00000176571,Unsafe,25683912,"The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal.",2015,10.1016/j.cellsig.2015.02.009,https://pubmed.ncbi.nlm.nih.gov/25683912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNBD1,ENSG00000176571,Unsafe,36140707,Whole-Genome Sequencing Reveals the Genomic Characteristics and Selection Signatures of Hainan Black Goat.,2022,10.3390/genes13091539,https://pubmed.ncbi.nlm.nih.gov/36140707/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNBD1,ENSG00000176571,Unsafe,26684240,Identification of the BRAF V600E mutation in gastroenteropancreatic neuroendocrine tumors.,2016,10.18632/oncotarget.6602,https://pubmed.ncbi.nlm.nih.gov/26684240/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNBD1,ENSG00000176571,Unsafe,26857262,Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability.,2016,10.1158/0008-5472.can-15-2443,https://pubmed.ncbi.nlm.nih.gov/26857262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNBD2,ENSG00000149646,Unsafe,37511295,"Morphological Observation and Transcriptome Analysis of Ciliogenesis in Urechis unicinctus (Annelida, Echiura).",2023,10.3390/ijms241411537,https://pubmed.ncbi.nlm.nih.gov/37511295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,41814414,Human MAGI1 expression in endothelial cells protects from the development of localized and systemic scleroderma in mice.,2026,10.1186/s13075-026-03777-y,https://pubmed.ncbi.nlm.nih.gov/41814414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,41546072,OGT-mediated O-GlcNAcylation of MAGI1 exacerbates high glucose-triggered inflammation and dedifferentiation of vascular smooth muscle cells by activating the PI3K/AKT pathway.,2026,10.1186/s41065-026-00643-4,https://pubmed.ncbi.nlm.nih.gov/41546072/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,40322041,MAGI1 attenuates osteoarthritis by regulating osteoclast fusion in subchondral bone through the RhoA-ROCK1 signaling pathway.,2025,10.1016/j.jot.2025.04.007,https://pubmed.ncbi.nlm.nih.gov/40322041/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,41852832,Adjacent domains drive the emergence of misfolded intermediates in the folding pathway of the PDZ4 from MAGI1.,2026,10.1016/j.bbadva.2026.100184,https://pubmed.ncbi.nlm.nih.gov/41852832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,39810176,Quantitative proteomic analysis unveils a critical role of VARS1 in hepatocellular carcinoma aggressiveness through the modulation of MAGI1 expression.,2025,10.1186/s12943-024-02206-5,https://pubmed.ncbi.nlm.nih.gov/39810176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,40625359,Barrier genes are associated with preterm birth.,2025,10.3389/fmed.2025.1580877,https://pubmed.ncbi.nlm.nih.gov/40625359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,41535900,"Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants.",2026,10.1186/s13059-025-03921-y,https://pubmed.ncbi.nlm.nih.gov/41535900/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,38325349,MiR-205-5p-Mediated MAGI1 Inhibition Attenuates the Injury Induced by Diabetic Nephropathy.,2024,10.1159/000535670,https://pubmed.ncbi.nlm.nih.gov/38325349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,38233821,Regulation of tissue factor activity by interaction with the first PDZ domain of MAGI1.,2024,10.1186/s12959-023-00580-6,https://pubmed.ncbi.nlm.nih.gov/38233821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,41661231,"RNAseq-based meta-analyses revealed tumor suppressor-inducer fusion events in liver, oral, and ovarian cancer in the Indian population: a cancer cell surviving mechanism.",2026,10.1080/15257770.2026.2624447,https://pubmed.ncbi.nlm.nih.gov/41661231/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,38184887,Lactate promoted cisplatin resistance in NSCLC by modulating the m6A modification-mediated FOXO3/MAGI1-IT1/miR-664b-3p/IL-6R axis.,2024,10.1016/j.neo.2023.100960,https://pubmed.ncbi.nlm.nih.gov/38184887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,41157614,Elucidating Alterations in Viral and Human Gene Expression Due to Human Papillomavirus Integration by Using Multimodal RNA Sequencing.,2025,10.3390/v17101344,https://pubmed.ncbi.nlm.nih.gov/41157614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,37566008,MAGI1 Prevents Senescence and Promotes the DNA Damage Response in ER+ Breast Cancer.,2023,10.3390/cells12151929,https://pubmed.ncbi.nlm.nih.gov/37566008/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,38745909,MIR4435-2HG as a possible novel predictive biomarker of chemotherapy response and death in pediatric B-cell ALL.,2024,10.3389/fmolb.2024.1385140,https://pubmed.ncbi.nlm.nih.gov/38745909/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,39694170,Potential molecular mechanisms of tobacco smoke exposure in Alzheimer's disease.,2025,10.1016/j.brainres.2024.149394,https://pubmed.ncbi.nlm.nih.gov/39694170/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,38748774,SRC inhibition enables formation of a growth suppressive MAGI1-PP2A complex in isocitrate dehydrogenase-mutant cholangiocarcinoma.,2024,10.1126/scitranslmed.adj7685,https://pubmed.ncbi.nlm.nih.gov/38748774/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,36082118,MAGI1 inhibits interferon signaling to promote influenza A infection.,2022,10.3389/fcvm.2022.791143,https://pubmed.ncbi.nlm.nih.gov/36082118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,34198584,"MAGI1, a Scaffold Protein with Tumor Suppressive and Vascular Functions.",2021,10.3390/cells10061494,https://pubmed.ncbi.nlm.nih.gov/34198584/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,34503076,A New Story of the Three Magi: Scaffolding Proteins and lncRNA Suppressors of Cancer.,2021,10.3390/cancers13174264,https://pubmed.ncbi.nlm.nih.gov/34503076/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,33707576,MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis.,2021,10.1038/s41598-021-85056-1,https://pubmed.ncbi.nlm.nih.gov/33707576/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,31908493,"MAGI1 Inhibits the Proliferation, Migration and Invasion of Glioma Cells.",2019,10.2147/ott.s230236,https://pubmed.ncbi.nlm.nih.gov/31908493/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,32198055,MiR-486-5p-directed MAGI1/Rap1/RASSF5 signaling pathway contributes to hydroquinone-induced inhibition of erythroid differentiation in K562 cells.,2020,10.1016/j.tiv.2020.104830,https://pubmed.ncbi.nlm.nih.gov/32198055/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,36680150,Distinct Whole Transcriptomic Profiles of the Bursa of Fabricius in Muscovy Ducklings Infected by Novel Duck Reovirus with Different Virulence.,2022,10.3390/v15010111,https://pubmed.ncbi.nlm.nih.gov/36680150/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,32009799,Silencing Of MAGI1 Promotes The Proliferation And Inhibits Apoptosis Of Glioma Cells Via The Wnt/β-Catenin And PTEN/AKT Signaling Pathways.,2019,10.2147/ott.s215400,https://pubmed.ncbi.nlm.nih.gov/32009799/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,36844630,Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas.,2023,10.3892/ol.2023.13707,https://pubmed.ncbi.nlm.nih.gov/36844630/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,36820519,CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles.,2023,10.7554/elife.81407,https://pubmed.ncbi.nlm.nih.gov/36820519/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,33328548,Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer.,2020,10.1038/s41598-020-79195-0,https://pubmed.ncbi.nlm.nih.gov/33328548/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,27445342,Pilot study of small bowel mucosal gene expression in patients with irritable bowel syndrome with diarrhea.,2016,10.1152/ajpgi.00037.2016,https://pubmed.ncbi.nlm.nih.gov/27445342/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,29730043,Identifying the genetic risk factors for treatment response to lurasidone by genome-wide association study: A meta-analysis of samples from three independent clinical trials.,2018,10.1016/j.schres.2018.04.006,https://pubmed.ncbi.nlm.nih.gov/29730043/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,26305897,Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND).,2015,10.1371/journal.pgen.1005352,https://pubmed.ncbi.nlm.nih.gov/26305897/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,25778467,Genetic modifiers of response to glucose-insulin-potassium (GIK) infusion in acute coronary syndromes and associations with clinical outcomes in the IMMEDIATE trial.,2015,10.1038/tpj.2015.10,https://pubmed.ncbi.nlm.nih.gov/25778467/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNKSR3,ENSG00000153721,Unsafe,28545409,Genetic variation and expression levels of tight junction genes identifies association between MAGI3 and inflammatory bowel disease.,2017,10.1186/s12876-017-0620-y,https://pubmed.ncbi.nlm.nih.gov/28545409/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,42249403,Does minimally invasive non-surgical therapy improve outcomes in splinted mandibular incisors? Results from a randomized trial.,2026,10.1186/s12903-026-08788-4,https://pubmed.ncbi.nlm.nih.gov/42249403/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,42321138,Cost Consequence Analysis of Non-Surgical Treatment Approaches for Patients With Periodontitis.,2026,10.1111/jcpe.70154,https://pubmed.ncbi.nlm.nih.gov/42321138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,40957475,Extremely low-frequency magnetic fields (ELF-MF) and radiofrequency: Risk of childhood CNS tumors in a city with elevated ELF-MF exposure.,2025,10.1016/j.envres.2025.122858,https://pubmed.ncbi.nlm.nih.gov/40957475/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,41371476,Deep data-independent acquisition-based plasma proteomic profiling unveils distinct molecular features in dengue fever with neutropenia.,2025,10.1016/j.virs.2025.12.005,https://pubmed.ncbi.nlm.nih.gov/41371476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,41869503,Effect of minimally invasive non-surgical periodontal therapy in former smokers with periodontitis on salivary IL-1β and PGE-2 profile.,2026,10.3389/froh.2026.1779330,https://pubmed.ncbi.nlm.nih.gov/41869503/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,38697671,Cerebral &lt;sup&gt;18&lt;/sup&gt;F-FDG PET/CT Metabolism as Diagnostic Signature for Central Nervous System Toxicity After Immune Checkpoint Blockade Cancer Treatment.,2024,10.2967/jnumed.123.267025,https://pubmed.ncbi.nlm.nih.gov/38697671/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,40574674,Development and validation of a carer need screening tool (CNST-11) for carers of older adults: a need-stratified tool for services matching.,2025,10.1093/geront/gnaf151,https://pubmed.ncbi.nlm.nih.gov/40574674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,40362900,Retrospective Analysis of the Impact of a Dietitian and the Canadian Nutrition Screening Tool in a Geriatric Oncology Clinic.,2025,10.3390/nu17091591,https://pubmed.ncbi.nlm.nih.gov/40362900/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,35662693,CNST is Characteristic of Leukemia Stem Cells and is Associated With Poor Prognosis in AML.,2022,10.3389/fphar.2022.888243,https://pubmed.ncbi.nlm.nih.gov/35662693/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,39527321,Evaluation of ploidy and the DNA index by flow cytometry in central nervous system tumors: a review.,2024,10.1007/s11033-024-10095-6,https://pubmed.ncbi.nlm.nih.gov/39527321/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,38674407,Factors Influencing Mortality in Children with Central Nervous System Tumors: A Cohort Study on Clinical Characteristics and Genetic Markers.,2024,10.3390/genes15040473,https://pubmed.ncbi.nlm.nih.gov/38674407/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,40362156,Integrative Transcriptomic and Metabolomic Analysis of Muscle and Liver Reveals Key Molecular Pathways Influencing Growth Traits in Zhedong White Geese.,2025,10.3390/ani15091341,https://pubmed.ncbi.nlm.nih.gov/40362156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,40211057,The effect of aldafermin expressing-Escherichia coli Nissle 1917 along with dietary change on visceral adipose tissue in MASLD mouse model.,2025,10.1038/s41366-025-01774-w,https://pubmed.ncbi.nlm.nih.gov/40211057/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,39892688,Investigating the Contribution of Coding Variants in Alcohol Use Disorder Using Whole-Exome Sequencing Across Ancestries.,2025,10.1016/j.biopsych.2025.01.020,https://pubmed.ncbi.nlm.nih.gov/39892688/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,33962616,Blocking circ-CNST suppresses malignant behaviors of osteosarcoma cells and inhibits glycolysis through circ-CNST-miR-578-LDHA/PDK1 ceRNA networks.,2021,10.1186/s13018-021-02427-0,https://pubmed.ncbi.nlm.nih.gov/33962616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,35742702,Clinical Benefits of Minimally Invasive Non-Surgical Periodontal Therapy as an Alternative of Conventional Non-Surgical Periodontal Therapy-A Pilot Study.,2022,10.3390/ijerph19127456,https://pubmed.ncbi.nlm.nih.gov/35742702/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,34511483,Changes in the neutrophil to lymphocyte ratio as predictors of outcome in pediatric patients with central nervous system tumors undergoing surgical resection.,2022,10.3233/cbm-200857,https://pubmed.ncbi.nlm.nih.gov/34511483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,35833528,A randomized multi-centre study on the effectiveness of non-surgical periodontal therapy in general practice.,2022,10.1111/jcpe.13703,https://pubmed.ncbi.nlm.nih.gov/35833528/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,30325514,Neurons with diverse phenotypes project from the caudal to the rostral nucleus of the solitary tract.,2018,10.1002/cne.24501,https://pubmed.ncbi.nlm.nih.gov/30325514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,31600676,"Ecological association between residential natural background radiation exposure and the incidence rate of childhood central nervous system tumors in France, 2000-2012.",2020,10.1016/j.jenvrad.2019.106071,https://pubmed.ncbi.nlm.nih.gov/31600676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,36148235,Emerging trends and research foci of oncolytic virotherapy for central nervous system tumors: A bibliometric study.,2022,10.3389/fimmu.2022.975695,https://pubmed.ncbi.nlm.nih.gov/36148235/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,34911530,Patient-reported experiences and outcomes following two different approaches for non-surgical periodontal treatment: a randomized field study.,2021,10.1186/s12903-021-02001-4,https://pubmed.ncbi.nlm.nih.gov/34911530/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,29120854,The protective effects of Bacillus licheniformis preparation on gastrointestinal disorders and inflammation induced by radiotherapy in pediatric patients with central nervous system tumor.,2018,10.1016/j.advms.2017.09.005,https://pubmed.ncbi.nlm.nih.gov/29120854/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,36990222,Effect of Autograft CD34+ Dose on Outcome in Pediatric Patients Undergoing Autologous Hematopoietic Stem Cell Transplant for Central Nervous System Tumors.,2023,10.1016/j.jtct.2023.03.024,https://pubmed.ncbi.nlm.nih.gov/36990222/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,20669827,CNST maternity standards and assessments and other NHSLA risk management initiatives.,2010,,https://pubmed.ncbi.nlm.nih.gov/20669827/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,19057142,Evaluation of methods for removing central nervous system tissue contamination from the surface of beef carcasses after splitting.,2008,10.1292/jvms.70.1225,https://pubmed.ncbi.nlm.nih.gov/19057142/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,17434798,"Assessing and credentialing standards of care: the UK Clinical Negligence Scheme for Trusts (CNST, Maternity).",2007,10.1016/j.bpobgyn.2007.02.011,https://pubmed.ncbi.nlm.nih.gov/17434798/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,22513746,Activation of NPY receptors suppresses excitatory synaptic transmission in a taste-feeding network in the lower brain stem.,2012,10.1152/ajpregu.00536.2011,https://pubmed.ncbi.nlm.nih.gov/22513746/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNST,ENSG00000162852,Unsafe,18435322,Research unwrapped. Obstetric skills and drills.,2008,,https://pubmed.ncbi.nlm.nih.gov/18435322/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTD1,ENSG00000176563,Unsafe,42339205,Identification of the homozygous truncating mutation in &lt;i&gt;CNTD1&lt;/i&gt; as a novel genetic cause of diminished ovarian reserve.,2026,10.1016/j.gendis.2025.101900,https://pubmed.ncbi.nlm.nih.gov/42339205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTD1,ENSG00000176563,Unsafe,40488668,CNTD1 is crucial for crossover formation in female meiosis and for establishing the ovarian reserve.,2025,10.1083/jcb.202401021,https://pubmed.ncbi.nlm.nih.gov/40488668/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTD1,ENSG00000176563,Unsafe,38421617,Formation of Different Polyploids Through Disrupting Meiotic Crossover Frequencies Based on cntd1 Knockout in Zebrafish.,2024,10.1093/molbev/msae047,https://pubmed.ncbi.nlm.nih.gov/38421617/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTD1,ENSG00000176563,Unsafe,38865271,RNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse.,2024,10.1073/pnas.2320995121,https://pubmed.ncbi.nlm.nih.gov/38865271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTD1,ENSG00000176563,Unsafe,42221552,Meiotic gene variants contribute to recurrent blastulation failure.,2026,10.1093/hropen/hoag039,https://pubmed.ncbi.nlm.nih.gov/42221552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTD1,ENSG00000176563,Unsafe,32640224,Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner.,2020,10.1016/j.celrep.2020.107858,https://pubmed.ncbi.nlm.nih.gov/32640224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTD1,ENSG00000176563,Unsafe,32555348,Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse.,2020,10.1038/s41467-020-16885-3,https://pubmed.ncbi.nlm.nih.gov/32555348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTD1,ENSG00000176563,Unsafe,36105063,Efficacy of microsurgery for congenital neural tube defects in newborns.,2022,,https://pubmed.ncbi.nlm.nih.gov/36105063/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTD1,ENSG00000176563,Unsafe,35854862,Intracranial subdural hemorrhage following closed neural tube defect repair: illustrative case.,2021,10.3171/case21159,https://pubmed.ncbi.nlm.nih.gov/35854862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTD1,ENSG00000176563,Unsafe,24891606,Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites.,2014,10.1083/jcb.201401122,https://pubmed.ncbi.nlm.nih.gov/24891606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTD1,ENSG00000176563,Unsafe,28400653,Clinicopathological Significance among Patients with In vivo Epidermal Nuclear Staining by Direct Immunofluorescence Study.,2017,10.4103/0019-5154.201749,https://pubmed.ncbi.nlm.nih.gov/28400653/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTD1,ENSG00000176563,Unsafe,26920220,The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis.,2016,10.7554/elife.12039,https://pubmed.ncbi.nlm.nih.gov/26920220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTD1,ENSG00000176563,Unsafe,37232908,"A Modified Electrochemical Sensor Based on N,S-Doped Carbon Dots/Carbon Nanotube-Poly(Amidoamine) Dendrimer Hybrids for Imatinib Mesylate Determination.",2023,10.3390/bios13050547,https://pubmed.ncbi.nlm.nih.gov/37232908/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTLN,ENSG00000044459,Unsafe,41681505,GWAS-Identified SNPs and Candidate Genes Influencing Sex in Loach (&lt;i&gt;Misgurnus anguillicaudatus&lt;/i&gt;).,2026,10.3390/ani16030524,https://pubmed.ncbi.nlm.nih.gov/41681505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTLN,ENSG00000044459,Unsafe,39640822,"High heritability of human facial traits reveals associations with CNTLN, BRCA1, and TMPRSS6 loci in Korean families.",2024,10.1016/j.heliyon.2024.e39173,https://pubmed.ncbi.nlm.nih.gov/39640822/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTLN,ENSG00000044459,Unsafe,36090173,Transcriptome sequencing reveals differences between leydig cells and sertoli cells of yak.,2022,10.3389/fvets.2022.960250,https://pubmed.ncbi.nlm.nih.gov/36090173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTLN,ENSG00000044459,Unsafe,38093163,Machine learning and experiments identifies SPINK1 as a candidate diagnostic and prognostic biomarker for hepatocellular carcinoma.,2023,10.1007/s12672-023-00849-2,https://pubmed.ncbi.nlm.nih.gov/38093163/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTLN,ENSG00000044459,Unsafe,40646437,Bivariate GWAS performed on rabbits divergently selected for intramuscular fat content reveals pleiotropic genomic regions and genes related to meat and carcass quality traits.,2025,10.1186/s12711-025-00971-5,https://pubmed.ncbi.nlm.nih.gov/40646437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTLN,ENSG00000044459,Unsafe,36788602,"Ultra-low-coverage genome-wide association study-insights into gestational age using 17,844 embryo samples with preimplantation genetic testing.",2023,10.1186/s13073-023-01158-7,https://pubmed.ncbi.nlm.nih.gov/36788602/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTLN,ENSG00000044459,Unsafe,34827207,Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells.,2021,10.3390/biology10111214,https://pubmed.ncbi.nlm.nih.gov/34827207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTLN,ENSG00000044459,Unsafe,37835677,Genome-Wide Association Study of Maternal Genetic Effects on Intramuscular Fat and Fatty Acid Composition in Rabbits.,2023,10.3390/ani13193071,https://pubmed.ncbi.nlm.nih.gov/37835677/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTLN,ENSG00000044459,Unsafe,27743375,Genetic resilience to amyloid related cognitive decline.,2017,10.1007/s11682-016-9615-5,https://pubmed.ncbi.nlm.nih.gov/27743375/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTLN,ENSG00000044459,Unsafe,33405298,iTRAQ-based proteomic analysis of the molecular mechanisms and downstream effects of fatty acid synthase in osteosarcoma cells.,2021,10.1002/jcla.23653,https://pubmed.ncbi.nlm.nih.gov/33405298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTLN,ENSG00000044459,Unsafe,26035058,Genome-wide copy-number variation study of psychosis in Alzheimer's disease.,2015,10.1038/tp.2015.64,https://pubmed.ncbi.nlm.nih.gov/26035058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTLN,ENSG00000044459,Unsafe,28854272,Overall survival in EGFR mutated non-small-cell lung cancer patients treated with afatinib after EGFR TKI and resistant mechanisms upon disease progression.,2017,10.1371/journal.pone.0182885,https://pubmed.ncbi.nlm.nih.gov/28854272/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTLN,ENSG00000044459,Unsafe,17668870,"Novel aphidicolin-inducible common fragile site FRA9G maps to 9p22.2, within the C9orf39 gene.",2007,10.1002/gcc.20484,https://pubmed.ncbi.nlm.nih.gov/17668870/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTLN,ENSG00000044459,Unsafe,27270507,Genetic variations associated with six-white-point coat pigmentation in Diannan small-ear pigs.,2016,10.1038/srep27534,https://pubmed.ncbi.nlm.nih.gov/27270507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTLN,ENSG00000044459,Unsafe,23827040,The use of redberry juniper (Juniperus pinchotii) to reduce Haemonchus contortus fecal egg counts and increase ivermectin efficacy.,2013,10.1016/j.vetpar.2013.06.010,https://pubmed.ncbi.nlm.nih.gov/23827040/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,41513972,Aberrant calcium signaling and neuronal activity in the L271H CACNA1D (Cav1.3) iPSC model of neurodevelopmental disease.,2026,10.1038/s41380-025-03429-8,https://pubmed.ncbi.nlm.nih.gov/41513972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,41326871,Cntn4 Gene Deficiency Promotes Autism-Like Phenotypes Associated with Gut Microbiota Perturbations and Gut-Brain Axis Metabolomic Alterations in Mice.,2025,10.1007/s12035-025-05567-0,https://pubmed.ncbi.nlm.nih.gov/41326871/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,38745463,CNTN4 modulates neural elongation through interplay with APP.,2024,10.1098/rsob.240018,https://pubmed.ncbi.nlm.nih.gov/38745463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,42251273,Metatranscriptomic analysis of upper and lower respiratory tract microbiomes in patients with tuberculosis and community-acquired pneumonia.,2026,10.1186/s12879-026-13614-x,https://pubmed.ncbi.nlm.nih.gov/42251273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,42071286,A posttranslational proteomic survey of a single anatomically preserved human 20-week postconception brain.,2026,10.1111/joa.70170,https://pubmed.ncbi.nlm.nih.gov/42071286/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,42870830,MIF-mediated intercellular crosstalk drives antigen-presenting-like cancer-associated fibroblast differentiation in triple-negative breast cancer via TGF-β signaling.,2026,10.21037/tcr-2026-1747,https://pubmed.ncbi.nlm.nih.gov/42870830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,39392894,Contactin-4 suppresses antitumor T cell responses by engaging amyloid precursor protein.,2024,10.1126/sciimmunol.adk7237,https://pubmed.ncbi.nlm.nih.gov/39392894/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,41384039,Case Report: developmental delay and intellectual disability linked to a maternally inherited derivative chromosome 3 from a t(3;8) translocation.,2025,10.3389/fgene.2025.1662915,https://pubmed.ncbi.nlm.nih.gov/41384039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,38736872,Screening and validation of atherosclerosis PAN-apoptotic immune-related genes based on single-cell sequencing.,2024,10.3389/fimmu.2024.1297298,https://pubmed.ncbi.nlm.nih.gov/38736872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,39317877,Contactin proteins in cerebrospinal fluid show different alterations in dementias.,2024,10.1007/s00415-024-12694-6,https://pubmed.ncbi.nlm.nih.gov/39317877/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,36544657,MiR-148a-3p attenuates apoptosis and inflammation by targeting CNTN4 in atherosclerosis.,2022,10.21037/atm-22-3768,https://pubmed.ncbi.nlm.nih.gov/36544657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,38674362,Genetic Alterations in a Large Population of Italian Patients Affected by Neurodevelopmental Disorders.,2024,10.3390/genes15040427,https://pubmed.ncbi.nlm.nih.gov/38674362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,35250268,Effect of the Minor C Allele of CNTN4 rs2619566 on Medial Hypothalamic Connectivity in Early-Stage Patients of Chinese Han Ancestry with Sporadic Amyotrophic Lateral Sclerosis.,2022,10.2147/ndt.s339456,https://pubmed.ncbi.nlm.nih.gov/35250268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,33542194,"Cntn4, a risk gene for neuropsychiatric disorders, modulates hippocampal synaptic plasticity and behavior.",2021,10.1038/s41398-021-01223-y,https://pubmed.ncbi.nlm.nih.gov/33542194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,39629711,Identification of Genetic Factors Related With Nonhereditary Colorectal Polyposis and Its Recurrence Through Genome-Wide Association Study.,2025,10.1111/jgh.16840,https://pubmed.ncbi.nlm.nih.gov/39629711/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,37272486,Clinicopathological characteristics of pheochromocytoma/paraganglioma and screening of prognostic markers.,2023,10.1002/jso.27358,https://pubmed.ncbi.nlm.nih.gov/37272486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,34415325,The autism risk gene CNTN4 modulates dendritic spine formation.,2021,10.1093/hmg/ddab233,https://pubmed.ncbi.nlm.nih.gov/34415325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,34602958,Partial Trisomy 13q/Monosomy 3p Resulting from a Paternal Reciprocal 3p;13q Translocation in a Boy with Facial Dysmorphism and Hypertrophic Cardiomyopathy.,2021,10.1159/000516058,https://pubmed.ncbi.nlm.nih.gov/34602958/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,40000390,Mapping the landscape of childhood obesity: genomic insights and socioeconomic status in Indian school-going children.,2025,10.1002/oby.24248,https://pubmed.ncbi.nlm.nih.gov/40000390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,39004488,Prenatal diagnosis of familial 3p26.3p25.3 deletion in a pregnancy associated with a favorable fetal outcome and asymptomatic carrier parent and family members in three generations.,2024,10.1016/j.tjog.2024.05.010,https://pubmed.ncbi.nlm.nih.gov/39004488/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,40428405,"Genome-Wide Association Studies and Candidate Genes for Egg Production Traits in Layers from an F&lt;sub&gt;2&lt;/sub&gt; Crossbred Population Produced Using Two Divergently Selected Chicken Breeds, Russian White and Cornish White.",2025,10.3390/genes16050583,https://pubmed.ncbi.nlm.nih.gov/40428405/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,35603200,Pediatric Pan-Central Nervous System Tumor Methylome Analyses Reveal Immune-Related LncRNAs.,2022,10.3389/fimmu.2022.853904,https://pubmed.ncbi.nlm.nih.gov/35603200/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,37120522,Rare recurrent copy number variations in metabotropic glutamate receptor interacting genes in children with neurodevelopmental disorders.,2023,10.1186/s11689-023-09483-z,https://pubmed.ncbi.nlm.nih.gov/37120522/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,29258006,Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A&lt;sub&gt;2&lt;/sub&gt; formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).,2018,10.1016/j.atherosclerosis.2017.12.013,https://pubmed.ncbi.nlm.nih.gov/29258006/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,32617516,Prediction of Nephrotoxicity Associated With Cisplatin-Based Chemotherapy in Testicular Cancer Patients.,2020,10.1093/jncics/pkaa032,https://pubmed.ncbi.nlm.nih.gov/32617516/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,26958094,Limited impact of Cntn4 mutation on autism-related traits in developing and adult C57BL/6J mice.,2016,10.1186/s11689-016-9140-2,https://pubmed.ncbi.nlm.nih.gov/26958094/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,34167897,The mechanism of action of oxytocin antagonist nolasiban in ART in healthy female volunteers.,2021,10.1016/j.rbmo.2021.01.003,https://pubmed.ncbi.nlm.nih.gov/34167897/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,33050709,Genetic determinants of ammonia-induced acute lung injury in mice.,2021,10.1152/ajplung.00276.2020,https://pubmed.ncbi.nlm.nih.gov/33050709/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,25959733,Contactin-4 mediates axon-target specificity and functional development of the accessory optic system.,2015,10.1016/j.neuron.2015.04.005,https://pubmed.ncbi.nlm.nih.gov/25959733/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,24225399,"Genetic factors associated with gemcitabine pharmacokinetics, disposition, and toxicity.",2014,10.1097/fpc.0000000000000016,https://pubmed.ncbi.nlm.nih.gov/24225399/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,25889363,"Personal exposure to PM2.5, genetic variants and DNA damage: a multi-center population-based study in Chinese.",2015,10.1016/j.toxlet.2015.04.007,https://pubmed.ncbi.nlm.nih.gov/25889363/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,29503163,Five novel loci associated with antipsychotic treatment response in patients with schizophrenia: a genome-wide association study.,2018,10.1016/s2215-0366(18)30049-x,https://pubmed.ncbi.nlm.nih.gov/29503163/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,28044437,Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1.,2017,10.1002/jcsm.12171,https://pubmed.ncbi.nlm.nih.gov/28044437/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,24529757,Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.,2014,10.1016/j.neurobiolaging.2014.01.014,https://pubmed.ncbi.nlm.nih.gov/24529757/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,24659297,Dysregulated expression of lipid storage and membrane dynamics factors in Tia1 knockout mouse nervous tissue.,2014,10.1007/s10048-014-0397-x,https://pubmed.ncbi.nlm.nih.gov/24659297/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,23922650,Association study of 167 candidate genes for schizophrenia selected by a multi-domain evidence-based prioritization algorithm and neurodevelopmental hypothesis.,2013,10.1371/journal.pone.0067776,https://pubmed.ncbi.nlm.nih.gov/23922650/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,14571131,"Cloning and characterization of the human neural cell adhesion molecule, CNTN4 (alias BIG-2).",2003,10.1159/000073412,https://pubmed.ncbi.nlm.nih.gov/14571131/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CNTN4,ENSG00000144619,Unsafe,11013081,Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members.,2000,10.1006/geno.2000.6310,https://pubmed.ncbi.nlm.nih.gov/11013081/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,42806392,Heart failure may promote breast cancer progression through a Col10a1-associated Tgf-β/Smad-EMT pathway.,2026,10.1186/s13062-026-00964-4,https://pubmed.ncbi.nlm.nih.gov/42806392/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,42163866,COL10A1 beyond skeletal development: a hypertrophic chondrocyte-specific collagen emerging as a potential biomarker and tumor microenvironment regulator in solid cancers.,2026,10.62347/evwj6469,https://pubmed.ncbi.nlm.nih.gov/42163866/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,42305518,COL10A1 overexpression potentially contributes to poor outcomes in breast cancer via autophagy and vasculogenic mimicry.,2026,10.21037/tcr-2025-aw-2165,https://pubmed.ncbi.nlm.nih.gov/42305518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,41302023,Cloning and Expression of &lt;i&gt;Col10a1&lt;/i&gt; Gene and Its Response to Wnt/TGF-β Signaling Inhibitors in the Chinese Three-Keeled Pond Turtle (&lt;i&gt;Mauremys reevesii&lt;/i&gt;).,2025,10.3390/ani15223315,https://pubmed.ncbi.nlm.nih.gov/41302023/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,42897652,COL10A1&lt;sup&gt;+&lt;/sup&gt; fibroblasts define rupture-prone abdominal aortic aneurysms and enable molecular risk stratification.,2026,10.1186/s12967-026-08689-8,https://pubmed.ncbi.nlm.nih.gov/42897652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,41963830,Overexpression of COL10A1 in extracellular matrix predicts poor outcome and promotes ovarian cancer progression.,2026,10.1186/s12885-026-15959-7,https://pubmed.ncbi.nlm.nih.gov/41963830/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,41815119,COL10A1 transcriptional regulation of ANXA5-mediated ferroptosis is involved in malignant progression of head and neck squamous cell carcinoma.,2026,10.21037/tcr-2025-1184,https://pubmed.ncbi.nlm.nih.gov/41815119/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,42863334,COL10A1 at the crossroads of tumor signaling networks and environment remodeling.,2026,10.1016/j.prp.2026.156704,https://pubmed.ncbi.nlm.nih.gov/42863334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,42353509,Is All Fat Created Equal? A Comparative Study of Chondrogenesis Potential of Peri-Ovarian Adipose Tissues in Dogs.,2026,10.3390/ani16121900,https://pubmed.ncbi.nlm.nih.gov/42353509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,41977392,"A Conserved Fibroblast-Myeloid Gene Signature in Digestive Cancers: Multi-Omics Integration Identifies &lt;i&gt;DCN&lt;/i&gt;, &lt;i&gt;COL10A1&lt;/i&gt;, &lt;i&gt;CTHRC1&lt;/i&gt;, and &lt;i&gt;TREM2&lt;/i&gt; as Candidate Microenvironmental Markers.",2026,10.3390/ijms27073208,https://pubmed.ncbi.nlm.nih.gov/41977392/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,42538547,Modulating mesenchymal stromal cells chondrogenesis through TGF-β1 pre-conditioning during monolayer expansion in pellet culture and in a 3D mechanical load model.,2026,10.1186/s12967-026-08719-5,https://pubmed.ncbi.nlm.nih.gov/42538547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,42778025,In vitro chondrogenic differentiation is improved by the BMP7-derived peptide p[63-82].,2026,10.1016/j.peptides.2026.171521,https://pubmed.ncbi.nlm.nih.gov/42778025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,42519341,"Integrated post-GWAS, single-cell, and functional analyses prioritize &lt;i&gt;TCTN2&lt;/i&gt; at an osteoarthritis locus associated with innate immunity-related cartilage remodeling.",2026,10.3389/fimmu.2026.1883412,https://pubmed.ncbi.nlm.nih.gov/42519341/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,42706449,A truncated COL10A1 protein causes Schmid metaphyseal chondrodysplasia via protein downregulation and impairing α1 trimer formation and secretion.,2026,10.1007/s10142-026-02044-2,https://pubmed.ncbi.nlm.nih.gov/42706449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,40826474,COL10A1&lt;sup&gt;+&lt;/sup&gt; fibroblasts promote colorectal cancer metastasis and M2 macrophage polarization with pan-cancer relevance.,2025,10.1186/s13046-025-03510-8,https://pubmed.ncbi.nlm.nih.gov/40826474/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,42769816,"Analysis of the clinical diagnostic efficacy of the novel serum markers lipase F, gastrokine 2 and the collagen X-type α1 chain in gastric cancer.",2026,10.5937/jomb0-59476,https://pubmed.ncbi.nlm.nih.gov/42769816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,41155302,Comparative Regenerative Efficacy of PRP Combined with Chondrocytes or Mesenchymal Stem Cells for Intervertebral Disc Regeneration in a Rabbit Model.,2025,10.3390/ijms262010007,https://pubmed.ncbi.nlm.nih.gov/41155302/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,41303526,COL10A1 Overexpression Promotes Gastric Cancer Aggressiveness Through EMT and Major Oncogenic Pathways.,2025,10.3390/ijms262211043,https://pubmed.ncbi.nlm.nih.gov/41303526/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,40169690,The regulatory effect of CoL10A1 to the intracranial vascular invasion and cell proliferation in breast cancer via EMT pathway.,2025,10.1038/s41598-025-87475-w,https://pubmed.ncbi.nlm.nih.gov/40169690/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,40380802,Resident CD24 &lt;sup&gt;+&lt;/sup&gt;LCN2 &lt;sup&gt;+&lt;/sup&gt; LPCs aggravate fibrosis and inflammatory progression via the recruitment of TPPP3 &lt;sup&gt;+&lt;/sup&gt;COL10A1 &lt;sup&gt;+&lt;/sup&gt; macrophages in NASH.,2025,10.3724/abbs.2025081,https://pubmed.ncbi.nlm.nih.gov/40380802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,41734664,Integrative transcriptomic and experimental analysis identifies collagen-associated hub genes bridging chronic hypersensitivity pneumonitis and lung cancer.,2026,10.1016/j.compbiolchem.2026.108970,https://pubmed.ncbi.nlm.nih.gov/41734664/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,42547787,"Prednisone, not vamorolone, suppresses novel serum bone and cartilage biomarkers associated with growth failure in children with Duchenne muscular dystrophy.",2026,10.1038/s41598-026-61162-w,https://pubmed.ncbi.nlm.nih.gov/42547787/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,41454937,"Clinical, Molecular Characteristics, and Genotype-Phenotype Relationships of Metaphyseal Chondrodysplasia Type Schmid.",2025,10.1007/s00223-025-01457-8,https://pubmed.ncbi.nlm.nih.gov/41454937/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,38147021,Experimental validation and pan-cancer analysis identified COL10A1 as a novel oncogene and potential therapeutic target in prostate cancer.,2023,10.18632/aging.205337,https://pubmed.ncbi.nlm.nih.gov/38147021/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,42577178,An integrative analysis of UFMylation-related genes reveals a prognostic signature and identifies GDF7 as a novel therapeutic target in gastric cancer.,2026,10.3389/fonc.2026.1853513,https://pubmed.ncbi.nlm.nih.gov/42577178/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,41393008,Parental benzo[a]pyrene exposure impacts histone modifications in osteoblast subpopulations.,2025,10.1093/eep/dvaf032,https://pubmed.ncbi.nlm.nih.gov/41393008/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,39392043,Oncogenic mechanisms of COL10A1 in cancer and clinical challenges (Review).,2024,10.3892/or.2024.8821,https://pubmed.ncbi.nlm.nih.gov/39392043/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,41402920,Gut microbiota and host transcriptome interactions reveal diagnostic biomarkers in MASLD-associated hepatocellular carcinoma.,2025,10.1186/s13099-025-00782-5,https://pubmed.ncbi.nlm.nih.gov/41402920/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,39525356,"Plasma COL10A1 Level, a Potential Diagnostic and Prognostic Biomarker for Pancreatic Ductal Adenocarcinoma.",2024,10.2147/ott.s474540,https://pubmed.ncbi.nlm.nih.gov/39525356/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,37585671,COL10A1 is a potential immunotherapy biomarker associated with immune infiltration and deficient mismatch repair in colon cancer.,2023,10.2217/imt-2023-0096,https://pubmed.ncbi.nlm.nih.gov/37585671/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,39939916,"Aberrant expression of collagen type X in solid tumor stroma is associated with EMT, immunosuppressive and pro-metastatic pathways, bone marrow stromal cell signatures, and poor survival prognosis.",2025,10.1186/s12885-025-13641-y,https://pubmed.ncbi.nlm.nih.gov/39939916/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,37974070,COL10A1 promotes tumorigenesis by modulating CD276 in pancreatic adenocarcinoma.,2023,10.1186/s12876-023-03045-2,https://pubmed.ncbi.nlm.nih.gov/37974070/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL10A1,ENSG00000123500,Unsafe,41848842,Targeting EFEMP1 enhances chondrogenesis and inhibits hypertrophic differentiation in a spontaneous osteoarthritis mouse model.,2026,10.1007/s00109-026-02656-y,https://pubmed.ncbi.nlm.nih.gov/41848842/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL20A1,ENSG00000101203,Unsafe,40906272,Loss of COL20A1 in Schwann Cells Alters Regeneration of the Neuromuscular Junction and Locomotor Activity in Mice.,2025,10.1007/s12031-025-02406-8,https://pubmed.ncbi.nlm.nih.gov/40906272/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL20A1,ENSG00000101203,Unsafe,41258181,A systems biology approach to identify key targets in KRAS/BRAF-mutated colorectal cancer.,2025,10.1007/s12672-025-03966-2,https://pubmed.ncbi.nlm.nih.gov/41258181/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL20A1,ENSG00000101203,Unsafe,40034336,Genome-wide CRISPR/Cas9 screening identifies key profibrotic regulators of TGF-β1-induced epithelial-mesenchymal transformation and pulmonary fibrosis.,2025,10.3389/fmolb.2025.1507163,https://pubmed.ncbi.nlm.nih.gov/40034336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL20A1,ENSG00000101203,Unsafe,41087885,Transcriptomic analysis in peripheral blood mononuclear cells from hyper and hypo weight-loss responders.,2025,10.1186/s12263-025-00783-8,https://pubmed.ncbi.nlm.nih.gov/41087885/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL20A1,ENSG00000101203,Unsafe,37630778,"The Microbiome, Epigenome, and Diet in Adults with Obesity during Behavioral Weight Loss.",2023,10.3390/nu15163588,https://pubmed.ncbi.nlm.nih.gov/37630778/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL20A1,ENSG00000101203,Unsafe,35763030,Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease.,2022,10.1007/s00125-022-05735-0,https://pubmed.ncbi.nlm.nih.gov/35763030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL20A1,ENSG00000101203,Unsafe,33130903,Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models.,2021,10.1093/neuonc/noaa249,https://pubmed.ncbi.nlm.nih.gov/33130903/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL20A1,ENSG00000101203,Unsafe,32986378,Transcriptome Profile of Next Generation Sequence Data Related to Inflammation on Nasopharyngeal Carcinoma Cases in Indonesia.,2020,10.31557/apjcp.2020.21.9.2763,https://pubmed.ncbi.nlm.nih.gov/32986378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL20A1,ENSG00000101203,Unsafe,31556357,Identification of KLRC2 as a candidate marker for brain tumor-initiating cells.,2019,10.1080/01616412.2019.1672390,https://pubmed.ncbi.nlm.nih.gov/31556357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL20A1,ENSG00000101203,Unsafe,26592359,Genome-wide RNA-Seq analysis of breast muscles of two broiler chicken groups differing in shear force.,2016,10.1111/age.12388,https://pubmed.ncbi.nlm.nih.gov/26592359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COL20A1,ENSG00000101203,Unsafe,24098497,Concurrent gene signatures for han chinese breast cancers.,2013,10.1371/journal.pone.0076421,https://pubmed.ncbi.nlm.nih.gov/24098497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CORO7,ENSG00000262246,Unsafe,41654136,Domain-selective folding of the tandem β-propeller protein Coronin 7 (Coro7) by the chaperonin CCT/TRiC.,2026,10.1016/j.jbc.2026.111258,https://pubmed.ncbi.nlm.nih.gov/41654136/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CORO7,ENSG00000262246,Unsafe,41198690,Mechanism of Arp2/3 complex branch disassembly by human Coro7.,2025,10.1038/s41467-025-64787-z,https://pubmed.ncbi.nlm.nih.gov/41198690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CORO7,ENSG00000262246,Unsafe,41688638,Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation.,2026,10.1038/s41588-026-02512-2,https://pubmed.ncbi.nlm.nih.gov/41688638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CORO7,ENSG00000262246,Unsafe,34306034,Lifespan-Associated Gene Expression Signatures of Recombinant BXD Mice Implicates Coro7 and Set in Longevity.,2021,10.3389/fgene.2021.694033,https://pubmed.ncbi.nlm.nih.gov/34306034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CORO7,ENSG00000262246,Unsafe,38391955,A Proteomic Investigation to Discover Candidate Proteins Involved in Novel Mechanisms of 5-Fluorouracil Resistance in Colorectal Cancer.,2024,10.3390/cells13040342,https://pubmed.ncbi.nlm.nih.gov/38391955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CORO7,ENSG00000262246,Unsafe,37092861,Brain transcriptome-wide association study implicates novel risk genes underlying schizophrenia risk.,2023,10.1017/s0033291723000417,https://pubmed.ncbi.nlm.nih.gov/37092861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CORO7,ENSG00000262246,Unsafe,33162394,CORO7 functions as a scaffold protein for the core kinase complex assembly of the Hippo pathway.,2021,10.1074/jbc.ra120.013297,https://pubmed.ncbi.nlm.nih.gov/33162394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CORO7,ENSG00000262246,Unsafe,37239355,"Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma.",2023,10.3390/genes14050995,https://pubmed.ncbi.nlm.nih.gov/37239355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CORO7,ENSG00000262246,Unsafe,36408811,A protein microarray-based serum proteomic investigation reveals distinct autoantibody signature in colorectal cancer.,2023,10.1002/prca.202200062,https://pubmed.ncbi.nlm.nih.gov/36408811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CORO7,ENSG00000262246,Unsafe,34884487,Molecular Pathogenesis of the Coronin Family: CORO2A Facilitates Migration and Invasion Abilities in Oral Squamous Cell Carcinoma.,2021,10.3390/ijms222312684,https://pubmed.ncbi.nlm.nih.gov/34884487/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CORO7,ENSG00000262246,Unsafe,25887538,"Implication of coronin 7 in body weight regulation in humans, mice and flies.",2015,10.1186/s12868-015-0151-9,https://pubmed.ncbi.nlm.nih.gov/25887538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CORO7,ENSG00000262246,Unsafe,35882828,DNA methylation and waist-to-hip ratio: an epigenome-wide association study in Chinese monozygotic twins.,2022,10.1007/s40618-022-01878-4,https://pubmed.ncbi.nlm.nih.gov/35882828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CORO7,ENSG00000262246,Unsafe,35794510,Targeted molecular profiling of salivary duct carcinoma with rhabdoid features highlights parallels to other apocrine and discohesive neoplasms: which phenotype should drive classification?,2022,10.1007/s12105-022-01464-3,https://pubmed.ncbi.nlm.nih.gov/35794510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CORO7,ENSG00000262246,Unsafe,35777526,"Modulation of DNA methylation and protein expression in the prefrontal cortex by repeated administration of D-lysergic acid diethylamide (LSD): Impact on neurotropic, neurotrophic, and neuroplasticity signaling.",2022,10.1016/j.pnpbp.2022.110594,https://pubmed.ncbi.nlm.nih.gov/35777526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CORO7,ENSG00000262246,Unsafe,36252120,Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing.,2022,10.1161/circgen.122.003712,https://pubmed.ncbi.nlm.nih.gov/36252120/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CORO7,ENSG00000262246,Unsafe,31801396,Biochemical and immunocytochemical characterization of coronins in platelets.,2020,10.1080/09537104.2019.1696457,https://pubmed.ncbi.nlm.nih.gov/31801396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CORO7,ENSG00000262246,Unsafe,21897848,Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice.,2011,10.1371/journal.pone.0023604,https://pubmed.ncbi.nlm.nih.gov/21897848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CORO7,ENSG00000262246,Unsafe,21130766,Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob.,2011,10.1016/j.febslet.2010.11.049,https://pubmed.ncbi.nlm.nih.gov/21130766/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,42418741,Development and Validation of a Cytochrome C Oxidase Subunit 6B2-Based Risk Model for Cholangiocarcinoma Recurrence.,2026,10.1200/po-26-00349,https://pubmed.ncbi.nlm.nih.gov/42418741/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,40699919,SETDB1 ensures the continuity of embryonic to adult neural stem cells through metabolic alterations in the dentate gyrus.,2025,10.1073/pnas.2424315122,https://pubmed.ncbi.nlm.nih.gov/40699919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,41697440,Comprehensive analysis of disulfidptosis-related genes identifies clinically actionable prognostic biomarkers in cholangiocarcinoma.,2026,10.1007/s12672-026-04592-2,https://pubmed.ncbi.nlm.nih.gov/41697440/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,40956396,WGCNA-Based Identification of Hub Genes and Key Pathways Involved in Obesity.,2026,10.1007/s12033-025-01503-8,https://pubmed.ncbi.nlm.nih.gov/40956396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,37423748,Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility.,2024,10.1538/expanim.23-0055,https://pubmed.ncbi.nlm.nih.gov/37423748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,38501414,[High expression of COX6B2 in gastric cancer is associated with poor long-term prognosis and promotes cell proliferation and cell cycle progression by inhibiting p53 signaling].,2024,10.12122/j.issn.1673-4254.2024.02.11,https://pubmed.ncbi.nlm.nih.gov/38501414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,32990599,"Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma.",2020,10.7554/elife.58108,https://pubmed.ncbi.nlm.nih.gov/32990599/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,40263598,SDCBP/Syntenin-1 stabilizes BACH1 by disassembling the SCF&lt;sup&gt;FBXO22&lt;/sup&gt;-BACH1 complex in triple-negative breast cancer.,2025,10.1038/s44318-025-00440-1,https://pubmed.ncbi.nlm.nih.gov/40263598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,41591382,Volatile gas exposure correlates with self-reported liver condition: insights from NHANES 2009-2018 and Mendelian randomization studies.,2026,10.1080/1354750x.2026.2623470,https://pubmed.ncbi.nlm.nih.gov/41591382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,37061993,Metabolic Reprogramming Driven by IGF2BP3 Promotes Acquired Resistance to EGFR Inhibitors in Non-Small Cell Lung Cancer.,2023,10.1158/0008-5472.can-22-3059,https://pubmed.ncbi.nlm.nih.gov/37061993/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,36250984,Tipping the balance toward stemness in trophoblast: Metabolic programming by Cox6B2.,2022,10.1096/fj.202200703rr,https://pubmed.ncbi.nlm.nih.gov/36250984/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,32415061,COX6B2 drives metabolic reprogramming toward oxidative phosphorylation to promote metastasis in pancreatic ductal cancer cells.,2020,10.1038/s41389-020-0231-2,https://pubmed.ncbi.nlm.nih.gov/32415061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,37886818,Mitochondrial subtype MB-G3 contains potential novel biomarkers and therapeutic targets associated with prognosis of medulloblastoma.,2023,10.1080/1354750x.2023.2276670,https://pubmed.ncbi.nlm.nih.gov/37886818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,38315405,Bioinformatics to analyze the differentially expressed genes in different degrees of Alzheimer's disease and their roles in progress of the disease.,2025,10.1007/s13353-024-00827-6,https://pubmed.ncbi.nlm.nih.gov/38315405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,34359134,Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profiles in Testes of Calves and Sexually Mature Wandong Bulls (Bos taurus).,2021,10.3390/ani11072006,https://pubmed.ncbi.nlm.nih.gov/34359134/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,35804806,Flaxseed Polysaccharide Alters Colonic Gene Expression of Lipid Metabolism and Energy Metabolism in Obese Rats.,2022,10.3390/foods11131991,https://pubmed.ncbi.nlm.nih.gov/35804806/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,34422965,Identification and validation of potential novel biomarkers to predict distant metastasis in differentiated thyroid cancer.,2021,10.21037/atm-21-383,https://pubmed.ncbi.nlm.nih.gov/34422965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,30054583,Genetic association of the cytochrome c oxidase-related genes with Alzheimer's disease in Han Chinese.,2018,10.1038/s41386-018-0144-3,https://pubmed.ncbi.nlm.nih.gov/30054583/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,29416685,Estrogen/ERα signaling axis participates in osteoblast maturation via upregulating chromosomal and mitochondrial complex gene expressions.,2018,10.18632/oncotarget.23453,https://pubmed.ncbi.nlm.nih.gov/29416685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,22941942,Molecular analysis of cell type-specific gene expression profile during mouse spermatogenesis by laser microdissection and qRT-PCR.,2013,10.1177/1933719112452939,https://pubmed.ncbi.nlm.nih.gov/22941942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,15905330,Identification of cancer/testis-antigen genes by massively parallel signature sequencing.,2005,10.1073/pnas.0502583102,https://pubmed.ncbi.nlm.nih.gov/15905330/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX6B2,ENSG00000160471,Unsafe,12874793,Cytochrome c oxidase of mammals contains a testes-specific isoform of subunit VIb--the counterpart to testes-specific cytochrome c?,2003,10.1002/mrd.10327,https://pubmed.ncbi.nlm.nih.gov/12874793/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX8C,ENSG00000187581,Unsafe,37423748,Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility.,2024,10.1538/expanim.23-0055,https://pubmed.ncbi.nlm.nih.gov/37423748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX8C,ENSG00000187581,Unsafe,34326397,CRISPR/Cas9-based genetic screen of SCNT-reprogramming resistant genes identifies critical genes for male germ cell development in mice.,2021,10.1038/s41598-021-94851-9,https://pubmed.ncbi.nlm.nih.gov/34326397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX8C,ENSG00000187581,Unsafe,27651783,Association between chromosomal aberration of COX8C and tethered spinal cord syndrome: array-based comparative genomic hybridization analysis.,2016,10.4103/1673-5374.189200,https://pubmed.ncbi.nlm.nih.gov/27651783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX8C,ENSG00000187581,Unsafe,29416685,Estrogen/ERα signaling axis participates in osteoblast maturation via upregulating chromosomal and mitochondrial complex gene expressions.,2018,10.18632/oncotarget.23453,https://pubmed.ncbi.nlm.nih.gov/29416685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
COX8C,ENSG00000187581,Unsafe,25107643,Differential expression of mitochondrial energy metabolism profiles across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett's oesophagus.,2014,10.1016/j.canlet.2014.07.035,https://pubmed.ncbi.nlm.nih.gov/25107643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPA5,ENSG00000158525,Unsafe,41771430,Expression and function of zebrafish carboxypeptidase A5 in neutrophils and mast cells.,2026,10.1016/j.fsi.2026.111239,https://pubmed.ncbi.nlm.nih.gov/41771430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPA5,ENSG00000158525,Unsafe,42081108,Dissecting shared genetic architecture between pan-cancer and aging-related traits: a genome-wide cross-trait analysis.,2026,10.1007/s10522-026-10446-9,https://pubmed.ncbi.nlm.nih.gov/42081108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPA5,ENSG00000158525,Unsafe,40821846,Single-cell transcriptomics unveils leukocyte heterogeneity in the gills of &lt;i&gt;Larimichthys crocea&lt;/i&gt; in response to parasitic infection.,2025,10.3389/fimmu.2025.1633701,https://pubmed.ncbi.nlm.nih.gov/40821846/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPA5,ENSG00000158525,Unsafe,33745502,Predicted gene 31453 (Gm31453) and the gene encoding carboxypeptidase A5 (Cpa5) are not essential for spermatogenesis and male fertility in the mouse.,2021,10.1071/rd20284,https://pubmed.ncbi.nlm.nih.gov/33745502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPA5,ENSG00000158525,Unsafe,38027148,Exploring lncRNAs associated with human pancreatic islet cell death induced by transfer of adoptive lymphocytes in a humanized mouse model.,2023,10.3389/fendo.2023.1244688,https://pubmed.ncbi.nlm.nih.gov/38027148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPA5,ENSG00000158525,Unsafe,40164284,"Feeding time modulates the daily rhythms of expression of digestive and metabolic enzymes in the liver, and food intake regulation and reward systems in the hypothalamus of the European sea bass (Dicentrarchus labrax).",2025,10.1016/j.cbpa.2025.111853,https://pubmed.ncbi.nlm.nih.gov/40164284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPA5,ENSG00000158525,Unsafe,34619175,Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases.,2022,10.1016/j.dci.2021.104273,https://pubmed.ncbi.nlm.nih.gov/34619175/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPA5,ENSG00000158525,Unsafe,22368273,The zebrafish reveals dependence of the mast cell lineage on Notch signaling in vivo.,2012,10.1182/blood-2011-10-385989,https://pubmed.ncbi.nlm.nih.gov/22368273/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPA5,ENSG00000158525,Unsafe,12676894,The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome.,2003,10.1136/jmg.40.4.249,https://pubmed.ncbi.nlm.nih.gov/12676894/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPA5,ENSG00000158525,Unsafe,11836249,Identification and characterization of three members of the human metallocarboxypeptidase gene family.,2002,10.1074/jbc.m112254200,https://pubmed.ncbi.nlm.nih.gov/11836249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPA5,ENSG00000158525,Unsafe,14962666,Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST-flanking region at human chromosome 7q32.,2004,10.1016/j.ygeno.2003.08.016,https://pubmed.ncbi.nlm.nih.gov/14962666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPA5,ENSG00000158525,Unsafe,11920156,Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region.,2002,10.1038/sj.mp.4001004,https://pubmed.ncbi.nlm.nih.gov/11920156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPA5,ENSG00000158525,Unsafe,41560696,A bi-functional pH-responsive chip with a soft hydrogel-supported 3D-like renal tumor model for sustained drug delivery.,2026,10.1039/d5sm01222h,https://pubmed.ncbi.nlm.nih.gov/41560696/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42852059,"CPT1A as a metabolic gatekeeper linking fatty acid oxidation, ferroptosis resistance, and breast cancer stemness.",2026,10.3389/fonc.2026.1959579,https://pubmed.ncbi.nlm.nih.gov/42852059/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42822612,Icaritin ameliorates diabetes-associated cognitive dysfunction by attenuating ferroptosis through PPARα/CPT1A-associated fatty acid oxidative regulation.,2026,10.1016/j.jep.2026.122448,https://pubmed.ncbi.nlm.nih.gov/42822612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,41342119,CPT1a Expression Is a Critical Cardioprotective Response to Pathological Stress That Enables Rescue by Gene Transfer.,2026,10.1161/circresaha.125.327403,https://pubmed.ncbi.nlm.nih.gov/41342119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42460735,Role of Fatty Acid Oxidation in Crohn's Disease and Ulcerative Colitis: Metabolomics Analysis and Experimental Evidence.,2026,10.1002/cbf.70246,https://pubmed.ncbi.nlm.nih.gov/42460735/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42902976,Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation.,2026,10.1002/advs.78393,https://pubmed.ncbi.nlm.nih.gov/42902976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,41274422,Rewiring lipid Metabolism: The central role of CPT1 in metabolic dysfunction.,2026,10.1016/j.pbiomolbio.2025.11.002,https://pubmed.ncbi.nlm.nih.gov/41274422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,40499287,Expression of Carnitine Palmitoyltransferase I Isotypes in Gingival Tissues of Human Periodontitis.,2025,10.1016/j.identj.2025.100837,https://pubmed.ncbi.nlm.nih.gov/40499287/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42597308,The emerging metabolic role and treatment target of CPT1A in CRC.,2026,10.3389/fcell.2026.1881073,https://pubmed.ncbi.nlm.nih.gov/42597308/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42884082,Conformational Sampling of CPT1A Enables Dynamic Structure-Based Ligand Screening.,2026,10.3390/ijms27198840,https://pubmed.ncbi.nlm.nih.gov/42884082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42762603,CPT1A alters granulosa cell proliferation and steroidogenic activity in association with fatty acid oxidation during goat follicular development.,2027,10.1016/j.theriogenology.2026.118198,https://pubmed.ncbi.nlm.nih.gov/42762603/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,41169246,Tau impedes glioma progression by enhancing fatty acid β-oxidation-induced cellular senescence.,2025,10.24272/j.issn.2095-8137.2025.066,https://pubmed.ncbi.nlm.nih.gov/41169246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42157037,Activation of PPARγ and CPT1A Mediates the Hepatoprotective Effect of Ginsenoside CK against NAFLD in Rats.,2026,10.1186/s12575-026-00340-6,https://pubmed.ncbi.nlm.nih.gov/42157037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42063966,Oleic acid improves pathological changes in Aβ1-42-induced astrocytes and Alzheimer's disease mouse models through PKA/ACACB/CPT1A.,2026,10.3389/fnins.2026.1771310,https://pubmed.ncbi.nlm.nih.gov/42063966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42829449,Lipid Accumulation Promotes Tumorigenic Behaviour of Colorectal Cancer Cells.,2026,10.1111/jcmm.71393,https://pubmed.ncbi.nlm.nih.gov/42829449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42544308,"&lt;i&gt;CPT1A, CYGB,&lt;/i&gt; and &lt;i&gt;MRPL3&lt;/i&gt; in pre-eclampsia: biomarkers identified from oxidative stress-related gene analysis.",2026,10.7717/peerj.21572,https://pubmed.ncbi.nlm.nih.gov/42544308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42385216,"Deficiency of Mitochondrial Fatty Acid Enzyme, CPT1A, Underlies Airway Epithelial Barrier Dysfunction in Severe Asthma.",2026,10.1111/all.70428,https://pubmed.ncbi.nlm.nih.gov/42385216/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42120628,Plasma acylcarnitine dysregulation associated with CPT1-mediated metabolism contributes to oral carcinogenesis.,2026,10.1038/s41598-026-52309-w,https://pubmed.ncbi.nlm.nih.gov/42120628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42681939,CPT1A through succinylation regulates the CTCF/LINC01503‒91aa feedback loop to promote gemcitabine resistance in pancreatic ductal adenocarcinoma.,2026,10.1002/ctm2.70776,https://pubmed.ncbi.nlm.nih.gov/42681939/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42615238,CPT1A Ameliorates &lt;i&gt;Staphylococcus aureus&lt;/i&gt;-Induced Impairment of the Blood-Milk Barrier and Mitochondrial Oxidative Stress in Mastitis by Promoting NLRP3 Succinylation.,2026,10.1177/10445498261473087,https://pubmed.ncbi.nlm.nih.gov/42615238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42664245,Effect of weight loss intervention on fat metabolism including adipocytokines and enzymes in children with simple obesity.,2026,10.1371/journal.pone.0357145,https://pubmed.ncbi.nlm.nih.gov/42664245/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42737643,&lt;i&gt;Astragalus membranaceus&lt;/i&gt; Root Extract Improves T Cell Immunity in CTX-Immunosuppressed Mice and Is Associated with Hypermethylation of the &lt;i&gt;Cpt1a&lt;/i&gt; Locus.,2026,10.3390/ijms27177746,https://pubmed.ncbi.nlm.nih.gov/42737643/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42694682,Lipid metabolism and the immune microenvironment in gastric cancer.,2026,10.3389/fimmu.2026.1890119,https://pubmed.ncbi.nlm.nih.gov/42694682/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42520474,Lipid metabolism in γδ T-cell activation: Implications for immunotherapy in ovarian cancer.,2026,10.1016/j.tranon.2026.102953,https://pubmed.ncbi.nlm.nih.gov/42520474/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42719252,Tumor microenvironment and signaling pathways in melanoma brain metastasis.,2026,10.21037/atm-2026-0127,https://pubmed.ncbi.nlm.nih.gov/42719252/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42875546,Compartment-specific PPARδ activity controls the outcome of cancer-immune cell competition and immunotherapy efficacy.,2026,10.1038/s41590-026-02685-2,https://pubmed.ncbi.nlm.nih.gov/42875546/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42913876,Fenofibrate enhances systemic antitumor efficacy of high- and low-dose radiotherapy plus PD-1 blockade through CD8&lt;sup&gt;+&lt;/sup&gt; T-cell metabolic reprogramming and LDRT tumor conditioning.,2026,10.1016/j.canlet.2026.218926,https://pubmed.ncbi.nlm.nih.gov/42913876/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42393159,Integrated bioinformatics analysis reveals fatty acid metabolism subtypes and immune landscape in recurrent implantation failure.,2026,10.1038/s41598-026-57894-4,https://pubmed.ncbi.nlm.nih.gov/42393159/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,40867868,Carnitine Shuttle and Ferroptosis in Cancer.,2025,10.3390/antiox14080972,https://pubmed.ncbi.nlm.nih.gov/40867868/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42386920,"Integrated metabolomic, cytotoxic, and computational investigation of Caralluma tuberculata extract in breast cancer cells.",2026,10.1038/s41598-026-57810-w,https://pubmed.ncbi.nlm.nih.gov/42386920/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42183207,"Succinylation in cancer immunotherapy: mechanisms, biomarkers, and therapeutic implications.",2026,10.3389/fimmu.2026.1794817,https://pubmed.ncbi.nlm.nih.gov/42183207/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,41558606,Metabolic vulnerabilities in ovarian cancer decoding the nexus between nutrient adaptation and therapy resistance.,2026,10.1016/j.jare.2026.01.047,https://pubmed.ncbi.nlm.nih.gov/41558606/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,41135952,CPT1A inhibition alleviates plasmacytoid dendritic cell-mediated immune suppression in colon cancer through fatty acid oxidation modulation.,2025,10.1136/jitc-2025-012162,https://pubmed.ncbi.nlm.nih.gov/41135952/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,41939835,Quantitative systems toxicology approach that integrates PBPK and core hepatic metabolism: a case study with valproic acid.,2026,10.3389/fphar.2026.1768190,https://pubmed.ncbi.nlm.nih.gov/41939835/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,40423770,Butyrate confers colorectal cancer cell resistance to anti-PD-1 therapy by promoting CPT1A-mediated fatty acid oxidation.,2025,10.1007/s12672-025-02686-x,https://pubmed.ncbi.nlm.nih.gov/40423770/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1A,ENSG00000110090,Unsafe,42624331,Long-chain fatty acid metabolism reprograms antitumor immunity: from molecular mechanisms to clinical translation.,2026,10.1016/j.bcp.2026.118377,https://pubmed.ncbi.nlm.nih.gov/42624331/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,42032056,Combining machine learning and multi-omics analysis to explore the role of CPT1C in colorectal tumor cancer transformation.,2026,10.1038/s41598-026-49553-5,https://pubmed.ncbi.nlm.nih.gov/42032056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,42265134,"Single-cell and experimental analyses identify mitochondria-related genes Hmgcs2, Nudt5, and Cpt1c in painful diabetic peripheral neuropathy.",2026,10.1038/s41598-026-54769-6,https://pubmed.ncbi.nlm.nih.gov/42265134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,41741705,Dual regulatory roles of CPT1C in chronic stress-induced depression-related outcomes.,2026,10.1038/s41380-026-03516-4,https://pubmed.ncbi.nlm.nih.gov/41741705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,40268191,"CPT1C deficiency in SF1 neurons impairs early metabolic adaptation to dietary fats, leading to obesity.",2025,10.1016/j.molmet.2025.102155,https://pubmed.ncbi.nlm.nih.gov/40268191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,41750220,Malonyl-CoA Decarboxylase: A Spotlight on Brain Aspects.,2026,10.3390/brainsci16020220,https://pubmed.ncbi.nlm.nih.gov/41750220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,41312619,Loss-of-Function Variants in CPT1C: No Support for a Causal Role in Hereditary Spastic Paraplegia.,2026,10.1002/mds.70144,https://pubmed.ncbi.nlm.nih.gov/41312619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,40499287,Expression of Carnitine Palmitoyltransferase I Isotypes in Gingival Tissues of Human Periodontitis.,2025,10.1016/j.identj.2025.100837,https://pubmed.ncbi.nlm.nih.gov/40499287/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,42798859,Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms.,2025,10.1002/wjo2.70067,https://pubmed.ncbi.nlm.nih.gov/42798859/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,39907104,Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells.,2025,10.20892/j.issn.2095-3941.2024.0459,https://pubmed.ncbi.nlm.nih.gov/39907104/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,41274422,Rewiring lipid Metabolism: The central role of CPT1 in metabolic dysfunction.,2026,10.1016/j.pbiomolbio.2025.11.002,https://pubmed.ncbi.nlm.nih.gov/41274422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,41069939,Investigating biomarkers of mitochondrial and aging-related genes in major depressive disorder through bioinformatics analysis.,2025,10.3389/fpsyt.2025.1653998,https://pubmed.ncbi.nlm.nih.gov/41069939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,41765248,Fenofibrate targets PPARα-CPT1C axis to reverse aging by regulating lipid metabolism and mitochondrial function.,2026,10.1016/j.phrs.2026.108154,https://pubmed.ncbi.nlm.nih.gov/41765248/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,38746869,CPT1C-positive cancer-associated fibroblast facilitates immunosuppression through promoting IL-6-induced M2-like phenotype of macrophage.,2024,10.1080/2162402x.2024.2352179,https://pubmed.ncbi.nlm.nih.gov/38746869/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,40106976,International Union of Basic and Clinical Pharmacology. CXIX. Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes.,2025,10.1016/j.pharmr.2025.100051,https://pubmed.ncbi.nlm.nih.gov/40106976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,39737739,Expanding molecular and clinical spectrum of CPT1C-associated hereditary spastic paraplegia (SPG73)-a case series.,2025,10.1002/acn3.52288,https://pubmed.ncbi.nlm.nih.gov/39737739/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,41153514,Children with Genetically Confirmed Hereditary Spastic Paraplegia: A Single-Center Experience.,2025,10.3390/children12101332,https://pubmed.ncbi.nlm.nih.gov/41153514/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,38783346,APC/C-regulated CPT1C promotes tumor progression by upregulating the energy supply and accelerating the G1/S transition.,2024,10.1186/s12964-024-01657-z,https://pubmed.ncbi.nlm.nih.gov/38783346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,39472682,Alteration of the metabolite interconversion enzyme in sperm and Sertoli cell of non-obstructive azoospermia: a microarray data and in-silico analysis.,2024,10.1038/s41598-024-77875-9,https://pubmed.ncbi.nlm.nih.gov/39472682/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,36693836,"To be or not to be a fat burner, that is the question for cpt1c in cancer cells.",2023,10.1038/s41419-023-05599-1,https://pubmed.ncbi.nlm.nih.gov/36693836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,41368029,Study on the differences of fat deposition in cattle-yak and yak based on transcriptomics and metabolomics.,2025,10.3389/fvets.2025.1620146,https://pubmed.ncbi.nlm.nih.gov/41368029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,41693942,Integrating transcriptome and proteome profiles to compare carcass and meat quality traits between Songliao and Songlei black pigs.,2026,10.3389/fnut.2026.1710841,https://pubmed.ncbi.nlm.nih.gov/41693942/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,36674468,Cpt1c Downregulation Causes Plasma Membrane Remodelling and Anthracycline Resistance in Breast Cancer.,2023,10.3390/ijms24020946,https://pubmed.ncbi.nlm.nih.gov/36674468/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,40312720,Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma.,2025,10.1186/s12943-025-02333-7,https://pubmed.ncbi.nlm.nih.gov/40312720/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,36568750,High relatedness of bioinformatic data and realistic experimental works on the potentials of Fasciola hepatica and F. gigantica cathepsin L1 as a diagnostic and vaccine antigen.,2022,10.3389/fpubh.2022.1054502,https://pubmed.ncbi.nlm.nih.gov/36568750/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,41404116,Integrated metabolomic and transcriptomic analysis reveals digestive tract adaptations to high altitude in Bayanbulak sheep.,2025,10.3389/fvets.2025.1687858,https://pubmed.ncbi.nlm.nih.gov/41404116/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,38419709,Identification of hub genes significantly linked to tuberous sclerosis related-epilepsy and lipid metabolism via bioinformatics analysis.,2024,10.3389/fneur.2024.1354062,https://pubmed.ncbi.nlm.nih.gov/38419709/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,35936710,Mutant p53-microRNA-200c-ZEB2-Axis-Induced CPT1C Elevation Contributes to Metabolic Reprogramming and Tumor Progression in Basal-Like Breast Cancers.,2022,10.3389/fonc.2022.940402,https://pubmed.ncbi.nlm.nih.gov/35936710/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,38509965,Identification and analysis of prognostic metabolic characteristics in colon adenocarcinoma.,2024,10.1016/j.heliyon.2024.e27388,https://pubmed.ncbi.nlm.nih.gov/38509965/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,34277122,Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence.,2021,10.1016/j.jpha.2020.04.004,https://pubmed.ncbi.nlm.nih.gov/34277122/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,32289751,Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence.,2020,10.18632/aging.103033,https://pubmed.ncbi.nlm.nih.gov/32289751/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,36179991,"Effect of triadimefon on rat placental morphology, function, and gene expression.",2022,10.1016/j.toxlet.2022.09.009,https://pubmed.ncbi.nlm.nih.gov/36179991/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,34482353,"Candidate host epigenetic marks predictive for HIV reservoir size, responsiveness to latency reversal, and viral rebound.",2021,10.1097/qad.0000000000003065,https://pubmed.ncbi.nlm.nih.gov/34482353/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,36692643,Metabolic heterogeneity in early-stage lung adenocarcinoma revealed by RNA-seq and scRNA-seq.,2023,10.1007/s12094-023-03082-z,https://pubmed.ncbi.nlm.nih.gov/36692643/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,30135643,Mechanisms of CPT1C-Dependent AMPAR Trafficking Enhancement.,2018,10.3389/fnmol.2018.00275,https://pubmed.ncbi.nlm.nih.gov/30135643/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,32908876,Development of an Immune Infiltration-Related Eight-Gene Prognostic Signature in Colorectal Cancer Microenvironment.,2020,10.1155/2020/2719739,https://pubmed.ncbi.nlm.nih.gov/32908876/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,25751282,Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic Paraplegia.,2015,10.1001/jamaneurol.2014.4769,https://pubmed.ncbi.nlm.nih.gov/25751282/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CPT1C,ENSG00000169169,Unsafe,12376098,A novel brain-expressed protein related to carnitine palmitoyltransferase I.,2002,10.1006/geno.2002.6845,https://pubmed.ncbi.nlm.nih.gov/12376098/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,42823414,CRACD loss drives hypoxia-induced immune escape in gastric cancer.,2026,10.1038/s41467-026-77348-9,https://pubmed.ncbi.nlm.nih.gov/42823414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,42643496,miR-204-5p attenuates inflammatory infiltration in early-stage chronic renal allograft dysfunction by modulating the IL-11/ERK1/2-NF-κB axis.,2026,10.3389/fimmu.2026.1764404,https://pubmed.ncbi.nlm.nih.gov/42643496/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,41353272,Actin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancer.,2025,10.1038/s41467-025-67078-9,https://pubmed.ncbi.nlm.nih.gov/41353272/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,42179969,Neural stem cell delivery of oncolytic CRAd-S-pk7 immunotherapy for stage 3 ovarian cancer: Dose-regimen studies.,2026,10.1016/j.omton.2026.201219,https://pubmed.ncbi.nlm.nih.gov/42179969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,42595809,Improving Functional Oral Intake in Head and Neck Cancer Survivors with Chronic Radiation-Associated Dysphagia - The Multicenter Randomized Controlled HIT-CRAD Trial.,2026,10.1007/s00455-026-10971-2,https://pubmed.ncbi.nlm.nih.gov/42595809/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,42185785,A clinical-radiomics model based on multiparametric MRI for discriminating solitary primary spinal tumors from solitary spinal metastases.,2026,10.1186/s12880-026-02448-3,https://pubmed.ncbi.nlm.nih.gov/42185785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,41669400,Doppler ultrasound for the evaluation of chronic renal allograft dysfunction.,2026,10.21037/qims-24-1573,https://pubmed.ncbi.nlm.nih.gov/41669400/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,40254392,Discovery and validation of frameshift-derived neopeptides in Lynch syndrome: paving the way for novel cancer prevention strategies.,2025,10.1136/jitc-2024-011177,https://pubmed.ncbi.nlm.nih.gov/40254392/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,38796854,CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma.,2024,10.1016/j.celrep.2024.114286,https://pubmed.ncbi.nlm.nih.gov/38796854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,41420436,Feasibility and Adherence to Home-Based Intensive Treatment Programs for Chronic Radiation-Associated Dysphagia in Head and Neck Cancer Survivors-The HIT-CRAD Trial.,2026,10.1002/hed.70136,https://pubmed.ncbi.nlm.nih.gov/41420436/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,39588000,Serum neuron-specific enolase (NSE) is associated with the overall survival of colorectal cancer: a retrospective study.,2024,10.7717/peerj.18617,https://pubmed.ncbi.nlm.nih.gov/39588000/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,40011711,A conditionally replicative adenovirus vector containing the synNotch receptor gene for the treatment of muscle-invasive bladder cancer.,2025,10.1038/s41417-025-00879-8,https://pubmed.ncbi.nlm.nih.gov/40011711/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,40175496,Detection and isolation of viable cancer cells mediated by spytag and spycatcher using conditionally replicative adenovirus and magnetic microbeads.,2025,10.1038/s41598-025-95671-x,https://pubmed.ncbi.nlm.nih.gov/40175496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,39056802,KRAS Mutation Subtypes and Their Association with Other Driver Mutations in Oncogenic Pathways.,2024,10.3390/cells13141221,https://pubmed.ncbi.nlm.nih.gov/39056802/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,38184210,The association between activation of the ERK1/2-NF-κB signaling pathway by TIMP2 expression and chronic renal allograft dysfunction in the CRAD rat model.,2024,10.1016/j.trim.2023.101984,https://pubmed.ncbi.nlm.nih.gov/38184210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,39201643,&lt;i&gt;CD47&lt;/i&gt; and &lt;i&gt;IFT57&lt;/i&gt; Are Colinear Genes That Are Highly Coexpressed in Most Cancers and Exhibit Parallel Cancer-Specific Correlations with Survival.,2024,10.3390/ijms25168956,https://pubmed.ncbi.nlm.nih.gov/39201643/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,41774747,Integrating sequence-based GWAS and comparative genomic analysis reveals conservation and species-specificity of putative functional variants influencing tail length and tail abnormalities in pigs and sheep.,2026,10.1371/journal.pone.0343836,https://pubmed.ncbi.nlm.nih.gov/41774747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,35172140,Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction.,2022,10.1016/j.celrep.2022.110390,https://pubmed.ncbi.nlm.nih.gov/35172140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,32962040,Cracd Marks the First Wave of Meiosis during Spermatogenesis and Is Mis-Expressed in Azoospermia Mice.,2020,10.3390/jdb8030021,https://pubmed.ncbi.nlm.nih.gov/32962040/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,38595983,Conditionally replicative adenovirus as a therapy for malignant peripheral nerve sheath tumors.,2024,10.1016/j.omton.2024.200783,https://pubmed.ncbi.nlm.nih.gov/38595983/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,38922640,"Antitumor Effect and Immunomodulatory Mechanism of ""Oncolytic Extracellular Vesicles"".",2024,10.1021/acs.nanolett.4c02279,https://pubmed.ncbi.nlm.nih.gov/38922640/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,38675381,"AutoPepVax, a Novel Machine-Learning-Based Program for Vaccine Design: Application to a Pan-Cancer Vaccine Targeting EGFR Missense Mutations.",2024,10.3390/ph17040419,https://pubmed.ncbi.nlm.nih.gov/38675381/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,36846668,Effects of KMT2D mutation and its exon 39 mutation on the immune microenvironment and drug sensitivity in colorectal adenocarcinoma.,2023,10.1016/j.heliyon.2023.e13629,https://pubmed.ncbi.nlm.nih.gov/36846668/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,38391964,The Development and Characterization of a Next-Generation Oncolytic Virus Armed with an Anti-PD-1 sdAb for Osteosarcoma Treatment In Vitro.,2024,10.3390/cells13040351,https://pubmed.ncbi.nlm.nih.gov/38391964/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,34214495,"Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial.",2021,10.1016/s1470-2045(21)00245-x,https://pubmed.ncbi.nlm.nih.gov/34214495/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,36677587,Improving the Transduction Efficiency and Antitumor Effect of Conditionally Replicative Adenovirus by Application of 6-cyclohexyl Methyl-β-D-maltoside.,2023,10.3390/molecules28020528,https://pubmed.ncbi.nlm.nih.gov/36677587/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,41234971,A Rare Case of Profound Pulmonary Venous Malformation in an Elderly Individual With Three Major Comorbidities: Genetic Insights.,2025,10.7759/cureus.94471,https://pubmed.ncbi.nlm.nih.gov/41234971/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRACD,ENSG00000109265,Unsafe,30361697,Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin.,2018,10.1038/s41556-018-0215-z,https://pubmed.ncbi.nlm.nih.gov/30361697/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,41373703,The Specific Pathogenicity Pattern of the Different &lt;i&gt;CRB1&lt;/i&gt; Isoforms Conditions Clinical Severity in Inherited Retinal Dystrophies.,2025,10.3390/ijms262311551,https://pubmed.ncbi.nlm.nih.gov/41373703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,41998480,Metabolomic signatures suggest altered bile acid and energy metabolism in CRB1- retinopathies.,2026,10.1007/s11306-026-02415-7,https://pubmed.ncbi.nlm.nih.gov/41998480/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,42376998,Pathogenicity Analysis of Two Novel CRB1 Mutations in Three Chinese Inherited Retinal Dystrophy Families and a Literature Review.,2026,10.1167/tvst.15.6.42,https://pubmed.ncbi.nlm.nih.gov/42376998/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,41358656,"Detailed Comparison Between Two Main Phenotypes of CRB1-Related Retinal Dystrophy, Pan-retinopathy and Maculopathy.",2025,10.1167/iovs.66.15.27,https://pubmed.ncbi.nlm.nih.gov/41358656/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,41679029,"Generation and characterization of iPSC lines (SPPHIi005-A, SPPHIi006-A, SPPHIi007-A) from a CRB1-mutation associated retinitis pigmentosa family.",2026,10.1016/j.scr.2026.103914,https://pubmed.ncbi.nlm.nih.gov/41679029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,41626423,Novel Genotype-Phenotype Correlations in &lt;i&gt;CRB1&lt;/i&gt;-Retinopathies: Insights from Isoforms and Protein Domains Linked to Disease Severity.,2026,10.1016/j.xops.2025.101010,https://pubmed.ncbi.nlm.nih.gov/41626423/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,40590804,A Phenotypic Study of CRB1 Retinopathy Secondary to the Variant p.(Pro836Thr) Prevalent in Those of Black African Ancestry.,2025,10.1167/iovs.66.9.3,https://pubmed.ncbi.nlm.nih.gov/40590804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,42390706,Early onset primary angle closure and foveal retinoschisis associated with a pseudo-homozygous CRB1 pathogenic variant.,2026,10.1007/s10633-026-10127-5,https://pubmed.ncbi.nlm.nih.gov/42390706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,42469820,CCR1 signaling as a common injury pathway in retinal degeneration.,2026,10.1186/s12974-026-03952-7,https://pubmed.ncbi.nlm.nih.gov/42469820/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,42078489,Using Steady-State Visual Evoked Potentials to Characterize Wide-Ranging Retinopathy Linked to &lt;i&gt;CRB1&lt;/i&gt;: Implications for Clinical Trials.,2026,10.34133/csbj.0042,https://pubmed.ncbi.nlm.nih.gov/42078489/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,41767327,A novel &lt;i&gt;CRB1&lt;/i&gt; variant presenting as Leber congenital amaurosis-8 with angle-closure glaucoma in a Chinese family.,2026,10.18240/ijo.2026.03.25,https://pubmed.ncbi.nlm.nih.gov/41767327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,42433200,CRB1 -Associated Inherited Retinal Dystrophies: Prospective Natural History Study With 4 Years of Follow-Up.,2026,10.1111/ceo.70142,https://pubmed.ncbi.nlm.nih.gov/42433200/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,38927596,Enhanced Learning and Memory in Patients with CRB1 Retinopathy.,2024,10.3390/genes15060660,https://pubmed.ncbi.nlm.nih.gov/38927596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,39922756,LMTK2 and CRB1 are two novel risk genes for Alzheimer's disease in Han Chinese.,2025,10.1016/j.tjpad.2025.100087,https://pubmed.ncbi.nlm.nih.gov/39922756/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,40243434,Expanding the Clinical Spectrum of &lt;i&gt;CRB1&lt;/i&gt;-Retinopathies: A Novel Genotype-Phenotype Correlation with Macular Dystrophy and Elevated Intraocular Pressure.,2025,10.3390/ijms26072836,https://pubmed.ncbi.nlm.nih.gov/40243434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,39982393,Elevated Plasma Complement Factors in CRB1-Associated Inherited Retinal Dystrophies.,2025,10.1167/iovs.66.2.55,https://pubmed.ncbi.nlm.nih.gov/39982393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,40412791,CRB1 mutations cause structural and molecular defects in patient-derived retinal pigment epithelium cells.,2025,10.1016/j.exer.2025.110445,https://pubmed.ncbi.nlm.nih.gov/40412791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,41242591,Unveiling Inflammation-Like Retinal Remodeling in CRB1-Associated Inherited Retinal Dystrophies: Insights From a Multicenter Study.,2026,10.1016/j.ajo.2025.11.008,https://pubmed.ncbi.nlm.nih.gov/41242591/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,39699888,Assessing Contrast Sensitivity Function in CRB1-Retinopathies: Exploring Child-Friendly Measures of Visual Function.,2024,10.1167/tvst.13.12.33,https://pubmed.ncbi.nlm.nih.gov/39699888/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,40546236,A Novel Pathogenic Variant in CRB1 as the Cause of Non-Syndromic Retinitis Pigmentosa in a Geographical Isolate in Northern Italy.,2025,10.1002/ajmg.a.64161,https://pubmed.ncbi.nlm.nih.gov/40546236/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,40408095,Elevated Visual Crowding in CRB1-Associated Retinopathies: Understanding Functional Visual Deficits Using Child-Friendly Computerized Testing.,2025,10.1167/iovs.66.5.32,https://pubmed.ncbi.nlm.nih.gov/40408095/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,40149532,Assessment of &lt;i&gt;CRB1&lt;/i&gt;-Associated Retinopathies Using the S-MAIA Fast Protocol and Spectral-Domain Optical Coherence Tomography.,2025,10.3390/biomedicines13030555,https://pubmed.ncbi.nlm.nih.gov/40149532/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,40933662,Bile Acid Metabolism Changes in Patients with a &lt;i&gt;CRB1&lt;/i&gt;-Associated Inherited Retinal Degeneration.,2025,10.1016/j.xops.2025.100704,https://pubmed.ncbi.nlm.nih.gov/40933662/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,38790254,"In Silico CRISPR-Cas-Mediated Base Editing Strategies for Early-Onset, Severe Cone-Rod Retinal Degeneration in Three &lt;i&gt;Crumbs homolog 1&lt;/i&gt; Patients, including the Novel Variant c.2833G&gt;A.",2024,10.3390/genes15050625,https://pubmed.ncbi.nlm.nih.gov/38790254/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,36830922,Clinical and Therapeutic Evaluation of the Ten Most Prevalent CRB1 Mutations.,2023,10.3390/biomedicines11020385,https://pubmed.ncbi.nlm.nih.gov/36830922/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,37886604,Characterization and AAV-mediated CRB gene augmentation in human-derived CRB1KO and CRB1KOCRB2+/- retinal organoids.,2023,10.1016/j.omtm.2023.101128,https://pubmed.ncbi.nlm.nih.gov/37886604/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,37792335,CRB1-Associated Retinal Dystrophy Patients Have Expanded Lewis Glycoantigen-Positive T Cells.,2023,10.1167/iovs.64.13.6,https://pubmed.ncbi.nlm.nih.gov/37792335/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,39728598,Leber congenital amaurosis: A clinical and genetic study from a tertiary eye care center.,2025,10.4103/ijo.ijo_545_24,https://pubmed.ncbi.nlm.nih.gov/39728598/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,41851861,Electroretinographic patterns of retinitis pigmentosa in a Palestinian cohort: a clinical and functional characterization.,2026,10.1186/s12886-026-04739-3,https://pubmed.ncbi.nlm.nih.gov/41851861/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,37084726,AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype.,2023,10.1016/j.stemcr.2023.03.014,https://pubmed.ncbi.nlm.nih.gov/37084726/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,42278079,Genomic Signatures of Selection Reveal Breed-Specific and Shared Adaptive Regions in South African Beef Cattle.,2026,10.3390/ani16111645,https://pubmed.ncbi.nlm.nih.gov/42278079/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,40367607,Revealing the underlying mechanisms of nanoplastics induces neuroinflammation: From transcriptomic analysis to in vivo and in vitro validation.,2025,10.1016/j.ecoenv.2025.118311,https://pubmed.ncbi.nlm.nih.gov/40367607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRB1,ENSG00000134376,Unsafe,15914641,MPP5 recruits MPP4 to the CRB1 complex in photoreceptors.,2005,10.1167/iovs.04-1417,https://pubmed.ncbi.nlm.nih.gov/15914641/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,42657999,Protective Effect of Calcitonin Gene-Related Peptide on Corneal Epithelial Barrier in Experimental Dry Eye Models.,2026,10.1167/iovs.67.10.65,https://pubmed.ncbi.nlm.nih.gov/42657999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,40257726,"Advancing Understanding of Cerebrovascular Hemodynamic Perturbations in Pediatric Cerebral Malaria Using a Modified Critical Closing Pressure Evaluation- A Prospective, Observational Study.",2025,10.1007/s12028-025-02245-w,https://pubmed.ncbi.nlm.nih.gov/40257726/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,42154421,Differential Metabolic and Transcriptional Responses of PBMCs to Blastocystis sp. Subtypes in Chemotherapy-Treated Colorectal Cancer Patients.,2026,10.1007/s11686-026-01297-y,https://pubmed.ncbi.nlm.nih.gov/42154421/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,41420405,"The effects of CYP450 inhibition on cerebrovascular control during rest and mild hypovolemia: An exploratory study in young, healthy adults.",2025,10.14814/phy2.70712,https://pubmed.ncbi.nlm.nih.gov/41420405/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,40983781,The impact of posture changes on critical closing pressure and resistance-area product regulation in healthy subjects.,2026,10.1007/s00421-025-05972-2,https://pubmed.ncbi.nlm.nih.gov/40983781/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,41511905,Critical Closing Pressure Mediates the Association of Intracranial Artery Calcification with White Matter Hyperintensities.,2026,10.1159/000549535,https://pubmed.ncbi.nlm.nih.gov/41511905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,41154025,4-Vinylguaiacol in Citri Reticulatae 'Chachiensis' Pericarpium Volatile Oil: A Microbial-Mediated Aging Marker Enhances Glucose Metabolism.,2025,10.3390/foods14203489,https://pubmed.ncbi.nlm.nih.gov/41154025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,39834503,The method described by Czosnyka is particularly suitable for measuring CPPe in patients undergoing cerebral angiography.,2024,10.3389/fsurg.2024.1488265,https://pubmed.ncbi.nlm.nih.gov/39834503/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,40771095,Cognitive brain lateralization through neurovascular coupling in healthy subjects: A statistical complexity analysis.,2025,10.14814/phy2.70492,https://pubmed.ncbi.nlm.nih.gov/40771095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,40038953,The Impact of the Estimation Strategy of the Cerebral Critical Closing Pressure on the Autoregulation Index.,2024,10.1109/embc53108.2024.10781748,https://pubmed.ncbi.nlm.nih.gov/40038953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,39296411,"Modified Beer-Lambert algorithm to measure pulsatile blood flow, critical closing pressure, and intracranial hypertension.",2024,10.1364/boe.529150,https://pubmed.ncbi.nlm.nih.gov/39296411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,40796269,Cerebral perfusion mismatch: challenging the validity of cerebral vascular resistance index in orthostatic stress.,2025,10.1152/ajpregu.00134.2025,https://pubmed.ncbi.nlm.nih.gov/40796269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,38838702,Determinants of the dynamic cerebral critical closing pressure response to changes in mean arterial pressure.,2024,10.1088/1361-6579/ad548d,https://pubmed.ncbi.nlm.nih.gov/38838702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,38801084,Anti-Hyperglycemic Effect of the Brown Slime Cap Mushroom Chroogomphus rutilus (Agaricomycetes) Crude Polysaccharide In Vitro and In Vivo.,2024,10.1615/intjmedmushrooms.2024053173,https://pubmed.ncbi.nlm.nih.gov/38801084/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,39227669,Exploration and validation of ceRNA regulatory networks in colorectal cancer based on associations whole transcriptome sequencing.,2024,10.1038/s41598-024-71465-5,https://pubmed.ncbi.nlm.nih.gov/39227669/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,39401208,Impact of different blood pressure targets on cerebral hemodynamics in septic shock: A prospective pilot study protocol-SEPSIS-BRAIN.,2024,10.1371/journal.pone.0304412,https://pubmed.ncbi.nlm.nih.gov/39401208/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,36039170,Comparison of optical measurements of critical closing pressure acquired before and during induced ventricular arrhythmia in adults.,2022,10.1117/1.nph.9.3.035004,https://pubmed.ncbi.nlm.nih.gov/36039170/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,37680339,Enhancing diffuse correlation spectroscopy pulsatile cerebral blood flow signal with near-infrared spectroscopy photoplethysmography.,2023,10.1117/1.nph.10.3.035008,https://pubmed.ncbi.nlm.nih.gov/37680339/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,39570199,Subcomponent analysis of the directional sensitivity of dynamic cerebral autoregulation.,2025,10.1152/ajpheart.00498.2024,https://pubmed.ncbi.nlm.nih.gov/39570199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,38021025,Cerebral hemodynamic monitoring combined with infusion test in hydrocephalus.,2023,10.1016/j.bas.2023.102705,https://pubmed.ncbi.nlm.nih.gov/38021025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,42264290,Upcycling waste cement paste powder into a composite cement-free heavy metal stabilization binder.,2026,10.1016/j.envres.2026.124977,https://pubmed.ncbi.nlm.nih.gov/42264290/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,41298514,Novel conductive polycarbazolic polymer embedded with palladium nanoparticles as a highly sensitive electrochemical sensor for hydrazine detection.,2025,10.1038/s41598-025-25980-8,https://pubmed.ncbi.nlm.nih.gov/41298514/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,39068293,Finite element modeling of active cracking in actively reinforced concrete pavement slab exposed to fluctuating temperature.,2024,10.1038/s41598-024-68414-7,https://pubmed.ncbi.nlm.nih.gov/39068293/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,39266607,Statistical and machine learning models for predicting spalling in CRCP.,2024,10.1038/s41598-024-69999-9,https://pubmed.ncbi.nlm.nih.gov/39266607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,37025201,Critical closing pressure as a new hemodynamic marker of cerebral small vessel diseases burden.,2023,10.3389/fneur.2023.1091075,https://pubmed.ncbi.nlm.nih.gov/37025201/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,36869208,Critical Closing Pressure and Cerebrovascular Resistance Responses to Intracranial Pressure Variations in Neurocritical Patients.,2023,10.1007/s12028-023-01691-8,https://pubmed.ncbi.nlm.nih.gov/36869208/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,37180721,The molecular mechanism for inhibiting the growth of nasopharyngeal carcinoma cells using polymethoxyflavonoids purified from pericarp of Citrus reticulata 'Chachi' via HSCCC.,2023,10.3389/fphar.2023.1096001,https://pubmed.ncbi.nlm.nih.gov/37180721/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,32579152,Relationship between genetic knowledge and familial communication of CRC risk and intent to communicate CRCP genetic information: insights from FamilyTalk eMERGE III.,2021,10.1093/tbm/ibaa054,https://pubmed.ncbi.nlm.nih.gov/32579152/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,35329708,Evaluation of Design Procedure and Performance of Continuously Reinforced Concrete Pavement According to AASHTO Design Methods.,2022,10.3390/ma15062252,https://pubmed.ncbi.nlm.nih.gov/35329708/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,32434188,Cerebral Hemodynamics Are Not Affected by the Size of the Patent Ductus Arteriosus.,2020,10.1159/000506835,https://pubmed.ncbi.nlm.nih.gov/32434188/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,31400517,Clinical exome sequencing vs. usual care for hereditary colorectal cancer diagnosis: A pilot comparative effectiveness study.,2019,10.1016/j.cct.2019.105820,https://pubmed.ncbi.nlm.nih.gov/31400517/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,36213442,NK-cell dysfunction of acute myeloid leukemia in relation to the renin-angiotensin system and neurotransmitter genes.,2022,10.1515/med-2022-0551,https://pubmed.ncbi.nlm.nih.gov/36213442/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,29417750,Does gradual change in head positioning affect cerebrovascular physiology?,2018,10.14814/phy2.13603,https://pubmed.ncbi.nlm.nih.gov/29417750/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,30328561,Cerebrovascular assessment of patients undergoing shoulder surgery in beach chair position using a multiparameter transcranial Doppler approach.,2019,10.1007/s10877-018-0211-7,https://pubmed.ncbi.nlm.nih.gov/30328561/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRCP,ENSG00000241258,Unsafe,10067875,Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein.,1999,10.1210/endo.140.3.6541,https://pubmed.ncbi.nlm.nih.gov/10067875/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,42910160,State-Dependent Decoupling of a CREM-Centric cAMP-Responsive Regulon and Survival in Hepatocellular Carcinoma.,2026,10.7150/ijms.140851,https://pubmed.ncbi.nlm.nih.gov/42910160/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,42550263,The CREM-IL-15 axis: decoding the persistence-exhaustion paradox in NK cell immunotherapy.,2026,10.1007/s00262-026-04506-9,https://pubmed.ncbi.nlm.nih.gov/42550263/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,42653390,CREM Marks TCR-Driven T-Cell Activation and Associates with Favorable Prognosis in Papillary Thyroid Carcinoma: A Single-Cell and Bulk Transcriptomic Study.,2026,10.3390/ijms27167387,https://pubmed.ncbi.nlm.nih.gov/42653390/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,42234402,Melatonin Alleviates Graft Biliary Fibrosis by Inhibiting VIM&lt;sup&gt;+&lt;/sup&gt; Cholangiocyte Subcluster via Hypoxia/TGF-β-CREM-VIM Axis.,2026,10.1002/advs.75885,https://pubmed.ncbi.nlm.nih.gov/42234402/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,40474948,Potential Role of CREM in Diabetes-Associated Testicular Dysfunction: Current Evidence and Future Perspectives.,2025,10.1002/rmb2.12661,https://pubmed.ncbi.nlm.nih.gov/40474948/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,42098702,Paternal Sertoli cell-derived extracellular vesicles transfer mtDNA and microRNA cargo to trigger germ cell oxidative stress and induce metabolic risks in offspring.,2026,10.1186/s12964-026-02889-x,https://pubmed.ncbi.nlm.nih.gov/42098702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,41569358,"Intracranial mesenchymal tumor, FET::CREB fusion-positive: An integrative analysis of 81 cases.",2026,10.1093/neuonc/noag001,https://pubmed.ncbi.nlm.nih.gov/41569358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,42173408,The cAMP response element modulator (CREM) in ulcerative colitis: Molecular mechanisms and therapeutic potential.,2026,10.1016/j.bcp.2026.118085,https://pubmed.ncbi.nlm.nih.gov/42173408/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,42863614,Effects of resistance exercise on testicular oxidative status and spermatogenic indices following RF-EMF exposure in adult male rats.,2026,10.1016/j.reprotox.2026.109374,https://pubmed.ncbi.nlm.nih.gov/42863614/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,41674925,&lt;i&gt;CREM&lt;/i&gt; regulates the tumor immune microenvironment and predicts prognosis in thyroid carcinoma.,2026,10.21037/tcr-2025-1673,https://pubmed.ncbi.nlm.nih.gov/41674925/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,42766668,A comprehensive full-length transcriptome landscape of cigarette smoke-exposed HASMCs reveals extensive remodeling of mRNA isoforms and regulatory networks.,2026,10.1371/journal.pone.0354604,https://pubmed.ncbi.nlm.nih.gov/42766668/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,41944931,A CREM-ITGA2B-MAPK axis drives proliferation and invasiveness in gastric cancer: insights from single-cell analysis.,2026,10.1007/s13402-026-01189-3,https://pubmed.ncbi.nlm.nih.gov/41944931/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,42764096,Nasal epithelial transcriptome-wide isoform-level expression and asthma endotypes in youth.,2026,10.1016/j.jaci.2026.09.005,https://pubmed.ncbi.nlm.nih.gov/42764096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,41814627,The Regulation of Vasomotor and Cardiorespiratory Pulsations Is Disrupted in Primary Central Nervous System Lymphoma: A Case-Control fMRI Study.,2026,10.1002/hbm.70495,https://pubmed.ncbi.nlm.nih.gov/41814627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,42023520,"Malignant epithelioid mesenchymal neoplasms with EWSR1/FUS::CREM fusions: clinicopathological and molecular genetic analysis of seven cases highlighting immunophenotypic heterogeneity, frequent aggressive behaviour, and diagnostic pitfalls.",2026,10.1111/his.70165,https://pubmed.ncbi.nlm.nih.gov/42023520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,42889303,eVLP-mediated CREM editing enhances cytotoxicity of bicistronic IL-15-armored CD19/BCMA dual-target CAR-NK cells.,2026,10.3389/fimmu.2026.1976202,https://pubmed.ncbi.nlm.nih.gov/42889303/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,42298399,β-Adrenergic receptors as immunomodulators in T cells: mechanisms of neuroimmune crosstalk and pathophysiological implications.,2026,10.1186/s10020-026-01526-0,https://pubmed.ncbi.nlm.nih.gov/42298399/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,40576353,The cAMP responsive element modulator (CREM) transcription factor influences susceptibility to undernutrition and infection.,2025,10.1128/mbio.01390-25,https://pubmed.ncbi.nlm.nih.gov/40576353/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,42692017,Aging microenvironment induces CD8&lt;sup&gt;+&lt;/sup&gt; T cell exhaustion by suppressing hepatic β-hydroxybutyrylate synthesis.,2026,10.1016/j.cmet.2026.08.009,https://pubmed.ncbi.nlm.nih.gov/42692017/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,42586608,PGE2-mediated NK cell reprogramming drives acquired immunotherapy resistance in lung adenocarcinoma.,2026,10.1136/jitc-2025-014673,https://pubmed.ncbi.nlm.nih.gov/42586608/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,42877753,A Pilot Study on Early-Phase Efficacy and Biomarker Analysis of Cervical Intralymphatic Immunotherapy for Seasonal Rhinoconjunctivitis.,2026,10.2147/jaa.s631998,https://pubmed.ncbi.nlm.nih.gov/42877753/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,42450224,Single-Cell Pan-Cancer Atlas Reveals GPR171 as a Candidate Marker of CD8&lt;sup&gt;+&lt;/sup&gt; T-Cell Dysfunction.,2026,10.3390/ijms27135958,https://pubmed.ncbi.nlm.nih.gov/42450224/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,40468083,CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells.,2025,10.1038/s41586-025-09087-8,https://pubmed.ncbi.nlm.nih.gov/40468083/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,39796118,Zinc Deficiency Exacerbates Lead-Induced Interleukin-2 Suppression by Regulating CREM Expression.,2024,10.3390/ijms26010254,https://pubmed.ncbi.nlm.nih.gov/39796118/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,42721757,"Chronic labetalol exposure induced dose-dependent testicular toxicity via disruptingt HPG-axis, spermatogenesis and steroidogenic pathways: A biochemical, molecular and histopathological evidence.",2026,10.1016/j.tice.2026.103924,https://pubmed.ncbi.nlm.nih.gov/42721757/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,41277293,Defining Critical Emergency Medicine (CrEM): A Delphi Study From Scandinavia.,2026,10.1111/aas.70150,https://pubmed.ncbi.nlm.nih.gov/41277293/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,42582102,Immune cells harbor their own microbiome-derived metabolome: a new layer of immunometabolic regulation.,2026,10.3389/fimmu.2026.1852583,https://pubmed.ncbi.nlm.nih.gov/42582102/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,16143638,Combinations of genetic changes in the human cAMP-responsive element modulator gene: a clue towards understanding some forms of male infertility?,2005,10.1093/molehr/gah209,https://pubmed.ncbi.nlm.nih.gov/16143638/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,14511788,Different CREM-isoform gene expression between equine and human normal and impaired spermatogenesis.,2003,10.1016/s0093-691x(03)00142-0,https://pubmed.ncbi.nlm.nih.gov/14511788/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CREM,ENSG00000095794,Unsafe,11044457,CREM activator and repressor isoforms in human testis: sequence variations and inaccurate splicing during impaired spermatogenesis.,2000,10.1093/molehr/6.11.967,https://pubmed.ncbi.nlm.nih.gov/11044457/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42906665,Cloning and Expression of CRH Genes in Epinephelus coioides and Their Application in Stress Resistance Evaluation.,2026,10.1016/j.fsi.2026.111796,https://pubmed.ncbi.nlm.nih.gov/42906665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42471538,The CRF‑CRFR1 Axis Mediates Prenatal Fear Stress‑Induced Hippocampal Mitochondrial Damage in Offspring via MAM Remodeling and Calcium Overload.,2026,10.1007/s10571-026-01780-0,https://pubmed.ncbi.nlm.nih.gov/42471538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42298686,A brain-lung circuit drives LPS-induced lung injury via sympathetic neutrophil axis.,2026,10.1186/s12974-026-03914-z,https://pubmed.ncbi.nlm.nih.gov/42298686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42669874,Whole-Brain Monosynaptic Inputs and Outputs of Corticotropin-Releasing Hormone Neurons of the Paraventricular Nucleus of the Hypothalamus in Male Mice.,2026,10.1002/cns.71127,https://pubmed.ncbi.nlm.nih.gov/42669874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42491700,WNK-SPAK-NKCC1/KCC2 pathway disrupts chloride homeostasis and drives hyperactivation of PVN-CRH neurons in essential hypertension.,2026,10.1016/j.isci.2026.116593,https://pubmed.ncbi.nlm.nih.gov/42491700/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42899147,"Glucocorticoids in breast cancer: physiologic mechanisms and relationship to risk, survival, and treatment response.",2026,10.3389/fendo.2026.1952560,https://pubmed.ncbi.nlm.nih.gov/42899147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42084407,Characterization of the corticotropin-releasing hormone family in largemouth bass and their expression profiles in response to feeding and acute and chronic heat stress.,2026,10.1111/jfb.70481,https://pubmed.ncbi.nlm.nih.gov/42084407/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42384227,GH responsiveness to corticotropin-releasing hormone identifies corticotroph-like somatotroph adenomas in acromegaly.,2026,10.1007/s11102-026-01714-5,https://pubmed.ncbi.nlm.nih.gov/42384227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42685902,Synergistic regulation of itch behaviors by corticotropin-releasing hormone neurons in the medial prefrontal cortex.,2026,10.1016/j.neuint.2026.106254,https://pubmed.ncbi.nlm.nih.gov/42685902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42409608,Mapping of oxytocin- and arginine vasopressin-expressing neurons with calbindin 1 or reelin in the male mouse brain.,2026,10.1111/jne.70228,https://pubmed.ncbi.nlm.nih.gov/42409608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42129178,Selective and differential roles of PVH&lt;sup&gt;CRH&lt;/sup&gt; neurotransmitters in diet-induced obesity in mice.,2026,10.1038/s41467-026-73102-3,https://pubmed.ncbi.nlm.nih.gov/42129178/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42455257,Mitigating Fixation Artifacts in Spatial Transcriptomics: Methodological Insights from Human Brain Tissue.,2026,10.1007/s12035-026-06033-1,https://pubmed.ncbi.nlm.nih.gov/42455257/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42774689,CRH neurons in the dorsal bed nucleus of the stria terminalis (dBNST) mediate contextual fear generalization.,2026,10.1016/j.ynstr.2026.100851,https://pubmed.ncbi.nlm.nih.gov/42774689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42348342,Postmortem Evidence of CRH Neuron Reduction in Narcolepsy Without Cataplexy With Borderline Hypocretin-1 Levels.,2026,10.1111/jsr.70395,https://pubmed.ncbi.nlm.nih.gov/42348342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,41741571,Integrated transcriptomic analysis of the temporal cortex identifies CRH and GAD2 as neuropathological markers and reveals altered immune microenvironment in Alzheimer's disease.,2026,10.1038/s41598-026-40762-6,https://pubmed.ncbi.nlm.nih.gov/41741571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42912997,Neural circuitry mediating hypercapnia-induced microarousal and impaired sleep depth.,2026,10.1126/sciadv.aei1892,https://pubmed.ncbi.nlm.nih.gov/42912997/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42265069,Top-down medial prefrontal cortex-to-hypothalamic paraventricular nucleus circuit regulates social avoidance and conditioned fear in male mice.,2026,10.1038/s41421-026-00893-6,https://pubmed.ncbi.nlm.nih.gov/42265069/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42040331,CRH neurons in the AM-ACC circuit drive chronic pain and anxiety comorbidity.,2026,10.3389/fnins.2026.1809769,https://pubmed.ncbi.nlm.nih.gov/42040331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42074344,Hexavalent Chromium Toxicity in the Pancreas: A Study on the Protective Effects of &lt;i&gt;Hypericum perforatum&lt;/i&gt; Extract.,2026,10.3390/ijms27083706,https://pubmed.ncbi.nlm.nih.gov/42074344/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,41853066,Corticotropin releasing hormone-expressing inputs to the thalamic paraventricular nucleus: pathways from mother to memory?,2026,10.1016/j.ynstr.2026.100794,https://pubmed.ncbi.nlm.nih.gov/41853066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,41239466,Olutasidenib for mutated IDH1 acute myeloid leukemia: final five-year results from the phase 2 pivotal cohort.,2025,10.1186/s13045-025-01751-w,https://pubmed.ncbi.nlm.nih.gov/41239466/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42015516,Phase I/II Trial of the FLT3 Kinase Inhibitor XY0206 in Patients With Relapsed/Refractory Acute Myeloid Leukemia.,2026,10.1111/ejh.70164,https://pubmed.ncbi.nlm.nih.gov/42015516/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42734838,Optimizing venetoclax duration with hypomethylating agents for newly diagnosed acute myeloid leukemia: impact on response and survival.,2026,10.1007/s00277-026-07219-2,https://pubmed.ncbi.nlm.nih.gov/42734838/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42890622,"Integrated transcriptomic, machine learning, and network pharmacology analyses reveal shared inflammatory biomarkers between intervertebral disc degeneration and osteoporosis.",2026,10.3389/fimmu.2026.1880102,https://pubmed.ncbi.nlm.nih.gov/42890622/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,41100923,Injectable heavy-atom-free photosensitizer platform for near-infrared activated synergistic photoimmunotherapy.,2026,10.1016/j.jcis.2025.139208,https://pubmed.ncbi.nlm.nih.gov/41100923/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42193398,"Neuroimmune Regulation of Microvascular Inflammation: The Heart-Brain Axis, Mast Cells, and the Protective Role of Flavonoids-A Comprehensive Review.",2026,10.3390/biomedicines14051073,https://pubmed.ncbi.nlm.nih.gov/42193398/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,41166307,Neuropeptide CRH prevents premature differentiation of OPCs following CNS injury and in early postnatal development.,2025,10.1016/j.celrep.2025.116474,https://pubmed.ncbi.nlm.nih.gov/41166307/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,39475462,FDA Approval Summary: Olutasidenib for Adult Patients with Relapsed or Refractory Acute Myeloid Leukemia with an Isocitrate Dehydrogenase 1 Mutation.,2025,10.1158/1078-0432.ccr-24-2196,https://pubmed.ncbi.nlm.nih.gov/39475462/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42180922,Clinical value and cost-effectiveness analysis of conditionally approved anticancer drugs in China from 2015 to 2023.,2026,10.21037/tcr-2026-1-0038,https://pubmed.ncbi.nlm.nih.gov/42180922/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42272166,"All-Oral Combination of Revumenib, Decitabine, and Venetoclax for Relapsed or Refractory AML (SAVE).",2026,10.1200/jco-26-01159,https://pubmed.ncbi.nlm.nih.gov/42272166/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42689432,Cusatuzumab combined with venetoclax with or without azacitidine in unfit patients with newly diagnosed acute myeloid leukemia: phase Ib ELEVATE study.,2026,10.3324/haematol.2026.300917,https://pubmed.ncbi.nlm.nih.gov/42689432/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42054806,Prenatal metal exposure moderates the effect of CRH-related DNA methylation in the placenta on infant communication outcomes at 2 months of age.,2026,10.1016/j.ecoenv.2026.120190,https://pubmed.ncbi.nlm.nih.gov/42054806/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,41222627,The novel regulatory role of miR-101a in CRH expression following low-concentration DEHP exposure in zebrafish embryos.,2025,10.1007/s10142-025-01758-z,https://pubmed.ncbi.nlm.nih.gov/41222627/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42511727,"Hypothesis on PTSD Pathophysiology: Role of CRH, Noradrenaline, and Glucocorticoid Receptors in an Amygdala-Centered Closed-Loop System.",2026,10.3390/ijms27146384,https://pubmed.ncbi.nlm.nih.gov/42511727/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,42489393,"Neoadjuvant Paclitaxel-Carboplatin Chemotherapy Followed by Cesarean Radical Hysterectomy in Pregnant Patients With Cervical Cancer: Obstetric, Neonatal, and Surgical Outcomes.",2026,10.1111/jog.70403,https://pubmed.ncbi.nlm.nih.gov/42489393/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,2783917,Preprocorticotropin releasing hormone: cDNA sequence and in vitro processing.,1989,10.1016/0303-7207(89)90128-7,https://pubmed.ncbi.nlm.nih.gov/2783917/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRH,ENSG00000147571,Unsafe,3262120,Isolation and characterization of a corticotropin-releasing hormone-like peptide from human placenta.,1988,10.1210/jcem-67-4-768,https://pubmed.ncbi.nlm.nih.gov/3262120/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,42258744,Lactate programs CRIP1 protein lactylation to drive synovial proliferation in rheumatoid arthritis.,2026,10.1172/jci.insight.200928,https://pubmed.ncbi.nlm.nih.gov/42258744/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,41986400,CRIP1 functions as an oncogene in acute myeloid leukemia by modulating glycolytic metabolic reprogramming.,2026,10.1038/s41598-026-43411-0,https://pubmed.ncbi.nlm.nih.gov/41986400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,41972184,Molecular insights into CRIP1 as an immunometabolic regulator revealed by CRIP1 knockout and single-cell transcriptomics.,2026,10.3389/fimmu.2026.1762474,https://pubmed.ncbi.nlm.nih.gov/41972184/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,40118853,"Cysteine-rich intestinal protein family: structural overview, functional diversity, and roles in human disease.",2025,10.1038/s41420-025-02395-y,https://pubmed.ncbi.nlm.nih.gov/40118853/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,42643032,Integrative Single-Cell and Spatial Transcriptomics Identifies CRIP1&lt;sup&gt;+&lt;/sup&gt; Prehypertrophic Chondrocytes as Inflammatory Hubs and a Valuable Diagnostic Biomarker for Osteoarthritis.,2026,10.1155/mi/1194367,https://pubmed.ncbi.nlm.nih.gov/42643032/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,42134671,The CRIP1/NFATC2/SREBF1 axis drives melanoma progression by promoting reactive oxygen species-mediated endoplasmic reticulum stress activation.,2026,10.1016/j.bcp.2026.118055,https://pubmed.ncbi.nlm.nih.gov/42134671/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,41107987,Discovering CRIP1: a novel core gene in osteoarthritis pathogenesis.,2025,10.1186/s41065-025-00576-4,https://pubmed.ncbi.nlm.nih.gov/41107987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,41988531,CRIP1 promotes docetaxel resistance and immune-associated cell death modulation in prostate cancer.,2026,10.3389/fphar.2026.1769906,https://pubmed.ncbi.nlm.nih.gov/41988531/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,42505420,TGFβ-Dependent Epithelial-Mesenchymal Plasticity in Immortalized Human Atrial Epicardial Cells: An mRNA Profiling Study.,2026,10.3390/cells15141313,https://pubmed.ncbi.nlm.nih.gov/42505420/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,42807581,"Correction to 'Advanced Lymphoblastic Lymphoma, NOS in Leukaemic Phase Presenting With Sudden and Fatal CNS Haemorrhage'.",2026,10.1155/crip/9856983,https://pubmed.ncbi.nlm.nih.gov/42807581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,42343844,[Overexpressing NDUFA13 and CRIP1 improves B cell injury and lung Lesions in COPD mouse models].,2026,10.12122/j.issn.1673-4254.2026.06.15,https://pubmed.ncbi.nlm.nih.gov/42343844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,42784567,Identification of transcriptomic signatures associated with an ac4C related gene set and candidate expression based clusters in osteoarthritis through integrative bioinformatics.,2026,10.1371/journal.pone.0359336,https://pubmed.ncbi.nlm.nih.gov/42784567/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,41067282,CRIP1 exacerbates osteoarthritis progression by recruiting UBE3A to induce the ubiquitination-mediated degradation of MFGE8.,2025,10.1016/j.bcp.2025.117407,https://pubmed.ncbi.nlm.nih.gov/41067282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,41670839,CRIP1 knockdown enhances glycolytic dependence and increases sensitivity to 2-Deoxy-D-Glucose in acute myeloid leukemia.,2026,10.1007/s11033-026-11546-y,https://pubmed.ncbi.nlm.nih.gov/41670839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,41898587,Whole Transcriptomic Analysis Identifies Candidate Biomarkers from Saliva of Temporomandibular Joint Osteoarthritis Patients.,2026,10.3390/ijms27062727,https://pubmed.ncbi.nlm.nih.gov/41898587/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,42178411,"Association between CRP rs1800947 genotypes, dexamethasone use, postoperative CRP level and morbidity in adult cardiac surgical patients in post-hoc analysis of the observational INFLACOR cohort trial.",2026,10.1038/s41598-026-54801-9,https://pubmed.ncbi.nlm.nih.gov/42178411/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,42182821,Hand to Mouth: Shifting the Bare-Minimum Accessibility Paradigm in XR Through Crip-Hacking and Crip-Aesthetics.,2026,10.1007/s11569-025-00494-9,https://pubmed.ncbi.nlm.nih.gov/42182821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,41079921,PRMT1/PRMT5-Mediated Differential Arginine Methylation of CRIP1 Promotes the Recurrence of Small Cell Lung Cancer after Chemotherapy.,2025,10.7150/ijbs.115225,https://pubmed.ncbi.nlm.nih.gov/41079921/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,39905216,CRIP1 inhibits cutaneous melanoma progression through TFAM-mediated mitochondrial biogenesis.,2025,10.1038/s41598-025-88373-x,https://pubmed.ncbi.nlm.nih.gov/39905216/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,42686397,[Calibrated respiratory inductance plethysmography in the evaluation of respiratory mechanics and diagnosis of obstructive sleep apnea-hypopnea syndrome in female patients].,2026,10.13201/j.issn.2096-7993.2026.09.007,https://pubmed.ncbi.nlm.nih.gov/42686397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,41854522,HTRA1+ Macrophages Induce T-cell Egress through CRIP1/NF-κB/CXCL12 to Limit the Effects of Immunotherapy in Triple-Negative Breast Cancer.,2026,10.1158/2326-6066.cir-25-1138,https://pubmed.ncbi.nlm.nih.gov/41854522/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,41662431,Breaking disulfide bonds in a weakly bactericidal α-defensin unleashes a potent antimicrobial peptide with an altered conformation.,2026,10.1371/journal.ppat.1013954,https://pubmed.ncbi.nlm.nih.gov/41662431/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,41217618,Single-cell hdWGCNA identifies ICI-related-colitis key CD8 + T cells linked to immunotherapy response and prognosis in colon cancer.,2025,10.1007/s12672-025-03891-4,https://pubmed.ncbi.nlm.nih.gov/41217618/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,41286029,Identification of a Treg-related gene signature for predicting prognosis and immunosuppression in skin cutaneous melanoma.,2025,10.1007/s10238-025-01941-3,https://pubmed.ncbi.nlm.nih.gov/41286029/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,41493673,"A bortezomib resistance-related gene signature predicts prognosis, with ARID5B downregulation associated with poor overall survival in multiple myeloma.",2026,10.1007/s12672-026-04383-9,https://pubmed.ncbi.nlm.nih.gov/41493673/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,37541772,CRIP1 fosters MDSC trafficking and resets tumour microenvironment via facilitating NF-κB/p65 nuclear translocation in pancreatic ductal adenocarcinoma.,2023,10.1136/gutjnl-2022-329349,https://pubmed.ncbi.nlm.nih.gov/37541772/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,40547036,The role and prognostic value of PANoptosis-related genes in skin cutaneous melanoma.,2025,10.3389/fimmu.2025.1605977,https://pubmed.ncbi.nlm.nih.gov/40547036/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,38267031,Effects of exposure to the neonicotinoid pesticide clothianidin on α-defensin secretion and gut microbiota in mice.,2024,10.1292/jvms.23-0514,https://pubmed.ncbi.nlm.nih.gov/38267031/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,41088793,Out of Sync? Rare Genetic Disease and the Chronopolitics of Care.,2025,10.1111/1467-9566.70106,https://pubmed.ncbi.nlm.nih.gov/41088793/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,40493887,Single-cell and clonal analysis of AL amyloidosis plasma cells and their bone marrow microenvironment.,2025,10.1182/blood.2024024719,https://pubmed.ncbi.nlm.nih.gov/40493887/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,37396303,A conserved epitope in VAR2CSA is targeted by a cross-reactive antibody originating from Plasmodium vivax Duffy binding protein.,2023,10.3389/fcimb.2023.1202276,https://pubmed.ncbi.nlm.nih.gov/37396303/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRIP1,ENSG00000213145,Unsafe,41463126,Multimodal Prehabilitation for Hernia Repair: Linking Metabolic Modulation and Mechanical Methods.,2025,10.3390/biomedicines13123117,https://pubmed.ncbi.nlm.nih.gov/41463126/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,42323668,Molecular characterization of thioredoxin peroxidases 1 from Trichinella spiralis and its potential in generating protective immunity.,2026,10.1186/s13071-026-07517-8,https://pubmed.ncbi.nlm.nih.gov/42323668/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,42897284,Dissecting the functional and spatial roles of peroxiredoxins as H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; scavengers and redox transducers.,2026,10.1007/s00018-026-06356-1,https://pubmed.ncbi.nlm.nih.gov/42897284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,41366310,Plasma proteomic signatures in HIV-infected individuals post-SARS-CoV-2 infection.,2025,10.1186/s12879-025-12307-1,https://pubmed.ncbi.nlm.nih.gov/41366310/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,40079119,"Novel insights into human CRISP2: localization in reproductive tissues and sperm, and molecular characterization†.",2025,10.1093/biolre/ioaf051,https://pubmed.ncbi.nlm.nih.gov/40079119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,39268471,Investigating the therapeutic potential of hesperidin targeting CRISP2 in intervertebral disc degeneration and cancer risk mitigation.,2024,10.3389/fphar.2024.1447152,https://pubmed.ncbi.nlm.nih.gov/39268471/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,41511368,Potential Proteins Associated with Canine Epididymal Sperm Motility.,2026,10.3390/cells15010085,https://pubmed.ncbi.nlm.nih.gov/41511368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,42254241,The influence of unhealthy lifestyle on semen quality: results from a cross-sectional study and Mendelian randomization analysis.,2026,10.1097/ms9.0000000000004982,https://pubmed.ncbi.nlm.nih.gov/42254241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,38921038,Molecular Biomarkers of Canine Reproductive Functions.,2024,10.3390/cimb46060367,https://pubmed.ncbi.nlm.nih.gov/38921038/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,39433128,Alpha-1-B glycoprotein (A1BG) inhibits sterol-binding and export by CRISP2.,2024,10.1016/j.jbc.2024.107910,https://pubmed.ncbi.nlm.nih.gov/39433128/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,42603518,"Transcriptomic insights into the coordinated regulation of signaling, apoptosis, immunity, and metabolism during Sinonovacula constricta larval metamorphosis.",2026,10.1016/j.cbd.2026.101977,https://pubmed.ncbi.nlm.nih.gov/42603518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,39393917,Poor venous outflow is associated with hyperintense acute reperfusion marker on follow-up MRI in patients with acute ischemic stroke with a large vessel occlusion.,2025,10.1136/jnis-2024-022064,https://pubmed.ncbi.nlm.nih.gov/39393917/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,33996980,Investigation Into the Relationship Between Sperm Cysteine-Rich Secretory Protein 2 (CRISP2) and Sperm Fertilizing Ability and Fertility of Boars.,2021,10.3389/fvets.2021.653413,https://pubmed.ncbi.nlm.nih.gov/33996980/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,38612267,"Detection of Protein Biomarkers Relevant to Sperm Characteristics and Fertility in Semen in Three Wild Felidae: The Flat-Headed Cat (Prionailurus planiceps), Fishing Cat (Prionailurus viverrinus), and Asiatic Golden Cat (Catopuma temminckii).",2024,10.3390/ani14071027,https://pubmed.ncbi.nlm.nih.gov/38612267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,40557487,Hypodensity Beyond the Ischemic Core: Penumbral Changes Detected With Relative Noncontrast Computed Tomography.,2025,10.1161/strokeaha.124.050317,https://pubmed.ncbi.nlm.nih.gov/40557487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,36054334,The fate of porcine sperm CRISP2 from the perinuclear theca before and after in vitro fertilization†.,2022,10.1093/biolre/ioac169,https://pubmed.ncbi.nlm.nih.gov/36054334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,37705744,"Exploration of diagnostic biomarkers, microenvironment characteristics, and ursolic acid's therapeutic effect for benign prostate hyperplasia.",2023,10.7150/ijbs.85739,https://pubmed.ncbi.nlm.nih.gov/37705744/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,40282343,Transcriptomic and Metabolomic Analysis of the Uterine Tissue of Yaoshan Chicken and Its Crossbreeds to Reveal the Molecular Mechanism Influencing Eggshell Quality.,2025,10.3390/genes16040383,https://pubmed.ncbi.nlm.nih.gov/40282343/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,39481708,"The effects of Fe3O4NPs@SiO2 and Fe3O4NPs@pectin nanoparticles on the MCF-7 breast cancer cell line and the expression of BAX, TPX1 and BCL2 genes.",2024,10.1016/j.ijbiomac.2024.137082,https://pubmed.ncbi.nlm.nih.gov/39481708/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,39643769,A New Differential Gene Expression Based Simulated Annealing for Solving Gene Selection Problem: A Case Study on Eosinophilic Esophagitis and Few Other Gastro-intestinal Diseases.,2025,10.1007/s10528-024-10987-z,https://pubmed.ncbi.nlm.nih.gov/39643769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,34440724,"CRISP2, CATSPER1 and PATE1 Expression in Human Asthenozoospermic Semen.",2021,10.3390/cells10081956,https://pubmed.ncbi.nlm.nih.gov/34440724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,36978953,"Expression of the H2O2 Biosensor roGFP-Tpx1.C160S in Fission and Budding Yeasts and Jurkat Cells to Compare Intracellular H2O2 Levels, Transmembrane Gradients, and Response to Metals.",2023,10.3390/antiox12030706,https://pubmed.ncbi.nlm.nih.gov/36978953/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,34066375,The Mitochondria-to-Cytosol H2O2 Gradient Is Caused by Peroxiredoxin-Dependent Cytosolic Scavenging.,2021,10.3390/antiox10050731,https://pubmed.ncbi.nlm.nih.gov/34066375/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,37222076,Chemical features of melanoma tumor resident TRG CDR3s associated with better survival probabilities.,2023,10.1097/cmr.0000000000000899,https://pubmed.ncbi.nlm.nih.gov/37222076/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,35063506,Prostate secretory protein 94 inhibits sterol binding and export by the mammalian CAP protein CRISP2 in a calcium-sensitive manner.,2022,10.1016/j.jbc.2022.101600,https://pubmed.ncbi.nlm.nih.gov/35063506/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,35403927,Basis for using thioredoxin as an electron donor by Schizosaccharomyces pombe Gpx1 and Tpx1.,2022,10.1186/s13568-022-01381-2,https://pubmed.ncbi.nlm.nih.gov/35403927/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,29859088,Using in vivo oxidation status of one- and two-component redox relays to determine H2O2 levels linked to signaling and toxicity.,2018,10.1186/s12915-018-0523-6,https://pubmed.ncbi.nlm.nih.gov/29859088/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,35131677,Antioxidant properties and transcriptome of cauda epididymis with different levels of fertility in Hu lambs.,2022,10.1016/j.theriogenology.2022.01.035,https://pubmed.ncbi.nlm.nih.gov/35131677/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,28698603,Identification of differentially methylated BRCA1 and CRISP2 DNA regions as blood surrogate markers for cardiovascular disease.,2017,10.1038/s41598-017-03434-0,https://pubmed.ncbi.nlm.nih.gov/28698603/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,31586057,Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity.,2019,10.1038/s41467-019-12475-0,https://pubmed.ncbi.nlm.nih.gov/31586057/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,28640807,Lack of a peroxiredoxin suppresses the lethality of cells devoid of electron donors by channelling electrons to oxidized ribonucleotide reductase.,2017,10.1371/journal.pgen.1006858,https://pubmed.ncbi.nlm.nih.gov/28640807/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,33198820,DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial.,2020,10.1186/s13073-020-00794-7,https://pubmed.ncbi.nlm.nih.gov/33198820/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,33106972,Volatile Organic Compounds as Insect Repellents and Plant Elicitors: an Integrated Pest Management (IPM) Strategy for Glasshouse Whitefly (Trialeurodes vaporariorum).,2020,10.1007/s10886-020-01229-8,https://pubmed.ncbi.nlm.nih.gov/33106972/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,24085515,"Use of hairy roots extracts for 2,4-DCP removal and toxicity evaluation by Lactuca sativa test.",2014,10.1007/s11356-013-2172-1,https://pubmed.ncbi.nlm.nih.gov/24085515/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRISP2,ENSG00000124490,Unsafe,22234851,"Phytoremediation of 2,4-dichlorophenol using wild type and transgenic tobacco plants.",2012,10.1007/s11356-011-0724-9,https://pubmed.ncbi.nlm.nih.gov/22234851/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,42194952,&lt;i&gt;Myodes rufocanus&lt;/i&gt; Cataract Identification and Transcriptome Analysis.,2026,10.3390/genes17050495,https://pubmed.ncbi.nlm.nih.gov/42194952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,42195049,Stage-Specific Expression of Lens-Associated Structural Genes During Early Embryogenesis in European Seabass (&lt;i&gt;Dicentrarchus labrax&lt;/i&gt;).,2026,10.3390/genes17050590,https://pubmed.ncbi.nlm.nih.gov/42195049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,41823501,βA4-Crystallin Mutations Disrupt Structural Stability and Crystallin Interactions in Congenital Cataract Pathogenesis.,2026,10.1167/iovs.67.3.29,https://pubmed.ncbi.nlm.nih.gov/41823501/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,39354039,Sex differences in the development of experimental diabetic retinopathy.,2024,10.1038/s41598-024-73279-x,https://pubmed.ncbi.nlm.nih.gov/39354039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,37056152,Srgap2 suppression ameliorates retinal ganglion cell degeneration in mice.,2023,10.4103/1673-5374.369122,https://pubmed.ncbi.nlm.nih.gov/37056152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,39994538,Identification of mutations associated with congenital cataracts in nineteen Chinese families.,2025,10.1186/s12886-025-03920-4,https://pubmed.ncbi.nlm.nih.gov/39994538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,35840783,A novel missense variant c.71G > T (p.Gly24Val) of the CRYBA4 gene contributes to autosomal-dominant congenital cataract in a Chinese family.,2023,10.1007/s10792-022-02386-3,https://pubmed.ncbi.nlm.nih.gov/35840783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,37048143,High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology.,2023,10.3390/cells12071070,https://pubmed.ncbi.nlm.nih.gov/37048143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,31555371,Novel mutations associated with autosomal-dominant congenital cataract identified in Chinese families.,2019,10.3892/etm.2019.7865,https://pubmed.ncbi.nlm.nih.gov/31555371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,30646012,Bidirectional Analysis of Cryba4-Crybb1 Nascent Transcription and Nuclear Accumulation of Crybb3 mRNAs in Lens Fibers.,2019,10.1167/iovs.18-25921,https://pubmed.ncbi.nlm.nih.gov/30646012/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,35307764,Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer.,2022,10.1186/s43556-022-00070-7,https://pubmed.ncbi.nlm.nih.gov/35307764/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,31935276,In silico analysis and high-risk pathogenic phenotype predictions of non-synonymous single nucleotide polymorphisms in human Crystallin beta A4 gene associated with congenital cataract.,2020,10.1371/journal.pone.0227859,https://pubmed.ncbi.nlm.nih.gov/31935276/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,29683234,Possible association of oestrogen and Cryba4 with masticatory muscle tendon-aponeurosis hyperplasia.,2019,10.1111/odi.12876,https://pubmed.ncbi.nlm.nih.gov/29683234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,34304179,Deciphering the association of intronic single nucleotide polymorphisms of crystallin gene family with congenital cataract.,2021,10.4103/ijo.ijo_3062_20,https://pubmed.ncbi.nlm.nih.gov/34304179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,29263643,Associations between CRYBA4 gene variants and high myopia in a Japanese population.,2017,10.2147/opth.s146038,https://pubmed.ncbi.nlm.nih.gov/29263643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,36368116,Comparative transcriptome analysis in the caput segment of yak and cattleyak epididymis.,2023,10.1016/j.theriogenology.2022.10.039,https://pubmed.ncbi.nlm.nih.gov/36368116/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,35412582,Patterns of Crystallin Gene Expression in Differentiation State Specific Regions of the Embryonic Chicken Lens.,2022,10.1167/iovs.63.4.8,https://pubmed.ncbi.nlm.nih.gov/35412582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,36237482,The Involvement of Insulin-Like Growth Factor 2 Messenger Ribonucleic Acid-Binding Protein 2 in the Regulation of the Expression of Breast Cancer-Related Genes.,2022,10.2147/bctt.s382566,https://pubmed.ncbi.nlm.nih.gov/36237482/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,35246225,Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation.,2022,10.1186/s13072-022-00440-z,https://pubmed.ncbi.nlm.nih.gov/35246225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,28272538,Partial duplication of the CRYBB1-CRYBA4 locus is associated with autosomal dominant congenital cataract.,2017,10.1038/ejhg.2017.33,https://pubmed.ncbi.nlm.nih.gov/28272538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,41344185,Visual toxicity of imidacloprid in zebrafish: Unraveling the pathways from ocular morphology to behavior via phototransduction dysregulation.,2026,10.1016/j.jhazmat.2025.140693,https://pubmed.ncbi.nlm.nih.gov/41344185/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,31136738,Lens differentiation is characterized by stage-specific changes in chromatin accessibility correlating with differentiation state-specific gene expression.,2019,10.1016/j.ydbio.2019.04.020,https://pubmed.ncbi.nlm.nih.gov/31136738/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,22553694,Epidemiology and molecular genetics of congenital cataracts.,2011,10.3980/j.issn.2222-3959.2011.04.20,https://pubmed.ncbi.nlm.nih.gov/22553694/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYBA4,ENSG00000196431,Unsafe,22669729,A missense mutation in CRYGD linked with autosomal dominant congenital cataract of aculeiform type.,2012,10.1007/s11010-012-1355-2,https://pubmed.ncbi.nlm.nih.gov/22669729/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,40776922,Case Report: A family of congenital cataract caused by a novel mutation in the CRYGC gene c.52G&gt;A.,2025,10.3389/fmed.2025.1624834,https://pubmed.ncbi.nlm.nih.gov/40776922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,40229141,Identification of Genetic Variants Causing Paediatric Cataract in Myanmar.,2025,10.1111/cge.14755,https://pubmed.ncbi.nlm.nih.gov/40229141/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,39994382,The c.119-123dup5bp mutation in human γC-crystallin destabilizes the protein and activates the unfolded protein response to cause highly variable cataracts.,2025,10.1038/s41598-025-90977-2,https://pubmed.ncbi.nlm.nih.gov/39994382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,37331601,A crystallin mutant cataract with mineral deposits.,2023,10.1016/j.jbc.2023.104935,https://pubmed.ncbi.nlm.nih.gov/37331601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,38650819,Lens Cytoskeleton: An Update on the Etiopathogenesis of Human Cataracts.,2024,10.7759/cureus.56793,https://pubmed.ncbi.nlm.nih.gov/38650819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,40868138,Genetic Landscape of Congenital Cataracts in a Swiss Cohort: Addressing Diagnostic Oversights in Nance-Horan Syndrome.,2025,10.3390/biomedicines13081883,https://pubmed.ncbi.nlm.nih.gov/40868138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,37203095,Distinct gene expression profiles underlie morphological and etiological differences in pediatric cataracts.,2023,10.4103/ijo.ijo_3269_22,https://pubmed.ncbi.nlm.nih.gov/37203095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,37367076,Study of The Molecular Nature of Congenital Cataracts in Patients from The Volga-Ural Region.,2023,10.3390/cimb45060327,https://pubmed.ncbi.nlm.nih.gov/37367076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,36670602,Molecular Genetic Analysis of Ukrainian Families with Congenital Cataracts.,2022,10.3390/children10010051,https://pubmed.ncbi.nlm.nih.gov/36670602/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,39395831,Incidental finding of a &lt;i&gt;BRCA2&lt;/i&gt; variant following whole genome sequencing to molecularly diagnose bilateral congenital cataracts.,2024,10.1136/bcr-2024-260755,https://pubmed.ncbi.nlm.nih.gov/39395831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,36246175,A Novel Mutation in CRYGC Mutation Associated with Autosomal Dominant Congenital Cataracts and Microcornea.,2022,10.1016/j.xops.2021.100093,https://pubmed.ncbi.nlm.nih.gov/36246175/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,37048143,High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology.,2023,10.3390/cells12071070,https://pubmed.ncbi.nlm.nih.gov/37048143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,28298635,Novel mutations in CRYGC are associated with congenital cataracts in Chinese families.,2017,10.1038/s41598-017-00318-1,https://pubmed.ncbi.nlm.nih.gov/28298635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,25475058,Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells.,2015,10.1038/cr.2014.160,https://pubmed.ncbi.nlm.nih.gov/25475058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,31523120,Mutation screening of crystallin genes in Chinese families with congenital cataracts.,2019,,https://pubmed.ncbi.nlm.nih.gov/31523120/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,33243271,The genetic landscape of crystallins in congenital cataract.,2020,10.1186/s13023-020-01613-3,https://pubmed.ncbi.nlm.nih.gov/33243271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,29386872,Mutations in crystallin genes result in congenital cataract associated with other ocular abnormalities.,2017,,https://pubmed.ncbi.nlm.nih.gov/29386872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,28546921,A novel frameshift mutation in CX46 associated with hereditary dominant cataracts in a Chinese family.,2017,10.18240/ijo.2017.05.04,https://pubmed.ncbi.nlm.nih.gov/28546921/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,23954869,A CRYGC gene mutation associated with autosomal dominant pulverulent cataract.,2013,10.1016/j.gene.2013.07.044,https://pubmed.ncbi.nlm.nih.gov/23954869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,32450668,[Transcriptome profiling of differentiated lenses through RNA sequencing].,2020,10.3760/cma.j.cn112142-20200222-00095,https://pubmed.ncbi.nlm.nih.gov/32450668/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,29774067,Estrogen receptors orchestrate cell growth and differentiation to facilitate liver regeneration.,2018,10.7150/thno.23624,https://pubmed.ncbi.nlm.nih.gov/29774067/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,24281366,"Exome sequencing in developmental eye disease leads to identification of causal variants in GJA8, CRYGC, PAX6 and CYP1B1.",2014,10.1038/ejhg.2013.268,https://pubmed.ncbi.nlm.nih.gov/24281366/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,22553694,Epidemiology and molecular genetics of congenital cataracts.,2011,10.3980/j.issn.2222-3959.2011.04.20,https://pubmed.ncbi.nlm.nih.gov/22553694/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,22669729,A missense mutation in CRYGD linked with autosomal dominant congenital cataract of aculeiform type.,2012,10.1007/s11010-012-1355-2,https://pubmed.ncbi.nlm.nih.gov/22669729/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CRYGC,ENSG00000163254,Unsafe,23508780,"Whole exome sequencing in dominant cataract identifies a new causative factor, CRYBA2, and a variety of novel alleles in known genes.",2013,10.1007/s00439-013-1289-0,https://pubmed.ncbi.nlm.nih.gov/23508780/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,41927596,Long-read assembly reveals vast transcriptional complexity in the placenta associated with metabolic and endocrine function.,2026,10.1038/s41467-026-71303-4,https://pubmed.ncbi.nlm.nih.gov/41927596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,42739431,Dual-gRNA CRISPR/Cas9 Deletion of CsDMR6 in Sweet Orange Supported by Improved In Vitro Regeneration.,2026,10.3390/plants15172664,https://pubmed.ncbi.nlm.nih.gov/42739431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,42178336,"VISFATIN: a novel modulator of placental endocrinology under physiological and pathological conditions-in vitro studies involving INSR, ERK1/2, and PKA signalling pathways.",2026,10.1038/s41598-026-52422-w,https://pubmed.ncbi.nlm.nih.gov/42178336/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,42913038,Mindfulness-based stress reduction during pregnancy is associated with changes in placental fatty acid metabolism and endocrine function.,2026,10.1016/j.placenta.2026.10.004,https://pubmed.ncbi.nlm.nih.gov/42913038/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,42920537,Phenotypic and metabolic characterization of an &lt;i&gt;ADH2&lt;/i&gt; deletion mutant associated with reduced fluconazole susceptibility in &lt;i&gt;Candida albicans&lt;/i&gt;.,2026,10.3389/fcimb.2026.1911561,https://pubmed.ncbi.nlm.nih.gov/42920537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,40424181,Comparative analysis of the syncytiotrophoblast in placenta tissue and trophoblast organoids using snRNA sequencing.,2025,10.7554/elife.101170,https://pubmed.ncbi.nlm.nih.gov/40424181/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,42169399,Mannosylinositol Phosphorylceramide Biosynthesis Is Required for Cell Surface Adaptation to Ethanol Stress in Saccharomyces cerevisiae.,2026,10.1111/mmi.70079,https://pubmed.ncbi.nlm.nih.gov/42169399/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,40362658,Evidence for Pituitary Repression of the Human Growth Hormone-Related Placental Lactogen Genes and a Role for P Sequences.,2025,10.3390/ijms26094421,https://pubmed.ncbi.nlm.nih.gov/40362658/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,41335537,Effect of vaspin on endocrine function in human placenta. &lt;i&gt;In vitro&lt;/i&gt; studies on BeWo cells and villous explants from the third trimester of pregnancy.,2025,10.26402/jpp.2025.4.09,https://pubmed.ncbi.nlm.nih.gov/41335537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,38566204,Investigating the impact of regulatory B cells and regulatory B cell-related genes on bladder cancer progression and immunotherapeutic sensitivity.,2024,10.1186/s13046-024-03017-8,https://pubmed.ncbi.nlm.nih.gov/38566204/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,38763341,Discrete placental gene expression signatures accompany diabetic disease classifications during pregnancy.,2025,10.1016/j.ajog.2024.05.014,https://pubmed.ncbi.nlm.nih.gov/38763341/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,35806078,Longitudinal Proteomic Analysis of Plasma across Healthy Pregnancies Reveals Indicators of Gestational Age.,2022,10.3390/ijms23137076,https://pubmed.ncbi.nlm.nih.gov/35806078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,37743728,Serum protein profile analysis via label-free quantitation proteomics in patients with early-onset preeclampsia.,2023,10.1080/01443615.2023.2259982,https://pubmed.ncbi.nlm.nih.gov/37743728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,38505085,Identification of prognostic biomarkers of smoking-related lung cancer.,2024,10.21037/jtd-23-1890,https://pubmed.ncbi.nlm.nih.gov/38505085/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,39268490,Synergistic &lt;i&gt;in vitro&lt;/i&gt; activity and mechanism of KBN lotion and miconazole nitrate against drug-resistant &lt;i&gt;Candida albicans&lt;/i&gt; biofilms.,2024,10.3389/fcimb.2024.1426791,https://pubmed.ncbi.nlm.nih.gov/39268490/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,40147358,A locus control region generates distinct active placental lactogen and inactive growth hormone gene domains in term placenta that are disrupted with obesity.,2025,10.1016/j.placenta.2025.03.012,https://pubmed.ncbi.nlm.nih.gov/40147358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,39243977,Establishment of functional trophoblast organoids from trophoblast cells of bovine placenta.,2024,10.1016/j.cdev.2024.203970,https://pubmed.ncbi.nlm.nih.gov/39243977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,35429924,A chalcone-syringaldehyde hybrid inhibits triple-negative breast cancer cell proliferation and migration by inhibiting CKAP2-mediated FAK and STAT3 phosphorylation.,2022,10.1016/j.phymed.2022.154087,https://pubmed.ncbi.nlm.nih.gov/35429924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,37625677,Cyclic strain of poly (methyl methacrylate) surfaces triggered the pathogenicity of Candida albicans.,2023,10.1016/j.actbio.2023.08.037,https://pubmed.ncbi.nlm.nih.gov/37625677/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,40254107,"Chemical composition of the traditional Chinese medicine compound (ICAM), its antifungal effects against Candida albicans, and the underlying Mechanisms: Therapeutic potential and safety evaluation for vulvovaginal candidiasis.",2025,10.1016/j.jep.2025.119844,https://pubmed.ncbi.nlm.nih.gov/40254107/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,42183140,A dual crosslinked biodegradable zwitterionic chitosan-lignosulfonate derived aerogel for microbial decontamination of wastewater.,2026,10.1039/d6ra01965j,https://pubmed.ncbi.nlm.nih.gov/42183140/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,31533811,Screening circulating proteins to identify biomarkers of fetal macrosomia.,2019,10.1186/s13104-019-4625-1,https://pubmed.ncbi.nlm.nih.gov/31533811/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,34614005,"Hedera rhombea inhibits the biofilm formation of Candida, thereby increases the susceptibility to antifungal agent, and reduces infection.",2021,10.1371/journal.pone.0258108,https://pubmed.ncbi.nlm.nih.gov/34614005/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,31357504,Efficacy of Compounds Isolated from Streptomyces olivaceus against the Morphogenesis and Virulence of Candida albicans.,2019,10.3390/md17080442,https://pubmed.ncbi.nlm.nih.gov/31357504/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,21710638,"Eomesodermin, HAND1, and CSH1 proteins are induced by cellular stress in a stress-activated protein kinase-dependent manner.",2011,10.1002/mrd.21342,https://pubmed.ncbi.nlm.nih.gov/21710638/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,20876741,"Cellular stress causes reversible, PRKAA1/2-, and proteasome-dependent ID2 protein loss in trophoblast stem cells.",2010,10.1530/rep-10-0268,https://pubmed.ncbi.nlm.nih.gov/20876741/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,26904013,Thiazolidinedione-8 Alters Symbiotic Relationship in C. albicans-S. mutans Dual Species Biofilm.,2016,10.3389/fmicb.2016.00140,https://pubmed.ncbi.nlm.nih.gov/26904013/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,18437100,Effects of prenatal tobacco exposure on gene expression profiling in umbilical cord tissue.,2008,10.1203/pdr.0b013e31817c5507,https://pubmed.ncbi.nlm.nih.gov/18437100/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH1,ENSG00000136488,Unsafe,19516908,Placenta-derived fetal specific mRNA is more readily detectable in maternal plasma than in whole blood.,2009,10.1371/journal.pone.0005858,https://pubmed.ncbi.nlm.nih.gov/19516908/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,41811437,Directed differentiation of bovine trophoblast stem cells: A useful in vitro model for placenta development.,2026,10.1073/pnas.2600783123,https://pubmed.ncbi.nlm.nih.gov/41811437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,41298965,Cross-species identification of conserved cell-type specific mechanisms during early placenta development in ruminants.,2025,10.1038/s41598-025-29895-2,https://pubmed.ncbi.nlm.nih.gov/41298965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,42309759,Trophoblast differentiation in the bovine placenta.,2026,10.1262/jrd.2025-121,https://pubmed.ncbi.nlm.nih.gov/42309759/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,38928272,Folding and Binding Kinetics of the Tandem of SH2 Domains from SHP2.,2024,10.3390/ijms25126566,https://pubmed.ncbi.nlm.nih.gov/38928272/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,40362658,Evidence for Pituitary Repression of the Human Growth Hormone-Related Placental Lactogen Genes and a Role for P Sequences.,2025,10.3390/ijms26094421,https://pubmed.ncbi.nlm.nih.gov/40362658/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,36095215,Nanobodies and chemical cross-links advance the structural and functional analysis of PI3Kα.,2022,10.1073/pnas.2210769119,https://pubmed.ncbi.nlm.nih.gov/36095215/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,34954235,The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance.,2022,10.1016/j.jmb.2021.167422,https://pubmed.ncbi.nlm.nih.gov/34954235/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,40147358,A locus control region generates distinct active placental lactogen and inactive growth hormone gene domains in term placenta that are disrupted with obesity.,2025,10.1016/j.placenta.2025.03.012,https://pubmed.ncbi.nlm.nih.gov/40147358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,34143834,Recruitment of phospholipase Cγ1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation.,2021,10.1371/journal.ppat.1009635,https://pubmed.ncbi.nlm.nih.gov/34143834/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,32117780,LRRC4 Suppresses E-Cadherin-Dependent Collective Cell Invasion and Metastasis in Epithelial Ovarian Cancer.,2020,10.3389/fonc.2020.00144,https://pubmed.ncbi.nlm.nih.gov/32117780/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,34725156,Cryo-EM structures of PI3Kα reveal conformational changes during inhibition and activation.,2021,10.1073/pnas.2109327118,https://pubmed.ncbi.nlm.nih.gov/34725156/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,37707543,Single-cell insights into development of the bovine placenta†.,2024,10.1093/biolre/ioad123,https://pubmed.ncbi.nlm.nih.gov/37707543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,34372761,Proteome profiling of human placenta reveals developmental stage-dependent alterations in protein signature.,2021,10.1186/s12014-021-09324-y,https://pubmed.ncbi.nlm.nih.gov/34372761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,34734802,Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors.,2021,10.7554/elife.74276,https://pubmed.ncbi.nlm.nih.gov/34734802/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,35367415,A kinetic model of phospholipase C-γ1 linking structure-based insights to dynamics of enzyme autoinhibition and activation.,2022,10.1016/j.jbc.2022.101886,https://pubmed.ncbi.nlm.nih.gov/35367415/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,28915558,"Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β.",2017,10.18632/oncotarget.19866,https://pubmed.ncbi.nlm.nih.gov/28915558/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,31831213,Defining How Oncogenic and Developmental Mutations of PIK3R1 Alter the Regulation of Class IA Phosphoinositide 3-Kinases.,2020,10.1016/j.str.2019.11.013,https://pubmed.ncbi.nlm.nih.gov/31831213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,29494137,Interaction of Calmodulin with the cSH2 Domain of the p85 Regulatory Subunit.,2018,10.1021/acs.biochem.7b01130,https://pubmed.ncbi.nlm.nih.gov/29494137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,28822827,Host genes regulate transcription of sperm-introduced hepatitis B virus genes in embryo.,2017,10.1016/j.reprotox.2017.08.009,https://pubmed.ncbi.nlm.nih.gov/28822827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,29972810,Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR.,2018,10.1016/j.bpj.2018.05.031,https://pubmed.ncbi.nlm.nih.gov/29972810/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,42183140,A dual crosslinked biodegradable zwitterionic chitosan-lignosulfonate derived aerogel for microbial decontamination of wastewater.,2026,10.1039/d6ra01965j,https://pubmed.ncbi.nlm.nih.gov/42183140/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,36356833,Regulation of CD28 binding to SH2 domains of Grb2 and PI3K by trisubstituted carboranes for T-cell activation.,2022,10.1016/j.bmcl.2022.129049,https://pubmed.ncbi.nlm.nih.gov/36356833/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,33386150,Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains.,2021,10.1016/j.molimm.2020.12.002,https://pubmed.ncbi.nlm.nih.gov/33386150/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,31918402,Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes.,2020,10.1016/j.ebiom.2019.102607,https://pubmed.ncbi.nlm.nih.gov/31918402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,32075097,&lt;i&gt;PIK3R1&lt;/i&gt;&lt;sup&gt;W624R&lt;/sup&gt; Is an Actionable Mutation in High Grade Serous Ovarian Carcinoma.,2020,10.3390/cells9020442,https://pubmed.ncbi.nlm.nih.gov/32075097/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,25227611,The autoinhibitory C-terminal SH2 domain of phospholipase C-γ2 stabilizes B cell receptor signalosome assembly.,2014,10.1126/scisignal.2005392,https://pubmed.ncbi.nlm.nih.gov/25227611/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,28167755,Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1.,2017,10.1073/pnas.1617244114,https://pubmed.ncbi.nlm.nih.gov/28167755/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSH2,ENSG00000213218,Unsafe,18437100,Effects of prenatal tobacco exposure on gene expression profiling in umbilical cord tissue.,2008,10.1203/pdr.0b013e31817c5507,https://pubmed.ncbi.nlm.nih.gov/18437100/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSHL1,ENSG00000204414,Unsafe,36858735,Identification of dysregulated canonical pathways associated with pathogenesis and progression of Amyotrophic Lateral Sclerosis-An integrated bioinformatics approach.,2023,10.1016/bs.apcsb.2022.11.014,https://pubmed.ncbi.nlm.nih.gov/36858735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSHL1,ENSG00000204414,Unsafe,34134622,High expression of LAMA3/AC245041.2 gene pair associated with KRAS mutation and poor survival in pancreatic adenocarcinoma: a comprehensive TCGA analysis.,2021,10.1186/s10020-021-00322-2,https://pubmed.ncbi.nlm.nih.gov/34134622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSHL1,ENSG00000204414,Unsafe,32126118,Changes in pregnancy-related serum biomarkers early in gestation are associated with later development of preeclampsia.,2020,10.1371/journal.pone.0230000,https://pubmed.ncbi.nlm.nih.gov/32126118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSHL1,ENSG00000204414,Unsafe,25563226,Differential transcriptome profile of peripheral white cells to identify biomarkers involved in oxaliplatin induced neuropathy.,2014,10.3390/jpm4020282,https://pubmed.ncbi.nlm.nih.gov/25563226/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSHL1,ENSG00000204414,Unsafe,20233782,Differential expression profile of growth hormone/chorionic somatomammotropin genes in placenta of small- and large-for-gestational-age newborns.,2010,10.1210/jc.2010-0023,https://pubmed.ncbi.nlm.nih.gov/20233782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSHL1,ENSG00000204414,Unsafe,18473352,Complex signatures of locus-specific selective pressures and gene conversion on Human Growth Hormone/Chorionic Somatomammotropin genes.,2008,10.1002/humu.20767,https://pubmed.ncbi.nlm.nih.gov/18473352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSHL1,ENSG00000204414,Unsafe,20092892,Effect of maternal tobacco smoke exposure on the placental transcriptome.,2010,10.1016/j.placenta.2009.12.016,https://pubmed.ncbi.nlm.nih.gov/20092892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSHL1,ENSG00000204414,Unsafe,2840669,Molecular basis of human growth hormone gene deletions.,1988,10.1073/pnas.85.15.5615,https://pubmed.ncbi.nlm.nih.gov/2840669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,42801564,Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries.,2026,10.1002/advs.202519007,https://pubmed.ncbi.nlm.nih.gov/42801564/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,40632521,"Variants in CSMD2 and CSMD3, genes involved in synaptogenesis, are associated with epilepsies.",2025,10.1111/epi.18539,https://pubmed.ncbi.nlm.nih.gov/40632521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,38163223,Preliminary study on the role of the CSMD2 gene in bladder cancer.,2024,10.1016/j.heliyon.2023.e22593,https://pubmed.ncbi.nlm.nih.gov/38163223/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,42278275,Molecular Mimicry by the Tick-Borne Encephalitis Virus E Protein: A Hidden Link to Autoimmunity.,2026,10.3390/ijms27114745,https://pubmed.ncbi.nlm.nih.gov/42278275/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,41129127,Exome and Genome Sequencing Reveals Novel Variants for Severe Diabetic Retinopathy in Type 1 Diabetes.,2025,10.1167/iovs.66.13.36,https://pubmed.ncbi.nlm.nih.gov/41129127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,36061177,"Integrated pan-cancer analysis of CSMD2 as a potential prognostic, diagnostic, and immune biomarker.",2022,10.3389/fgene.2022.918486,https://pubmed.ncbi.nlm.nih.gov/36061177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,40646788,"Genetic Parameters, Linear Associations, and Genome-Wide Association Study for Endotoxin-Induced Cortisol Response in &lt;i&gt;Holstein heifers&lt;/i&gt;.",2025,10.3390/ani15131890,https://pubmed.ncbi.nlm.nih.gov/40646788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,39049823,Differential microRNA expression in the SH-SY5Y human cell model as potential biomarkers for Huntington's disease.,2024,10.3389/fncel.2024.1399742,https://pubmed.ncbi.nlm.nih.gov/39049823/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,38649688,Biallelic variants identified in 36 Pakistani families and trios with autism spectrum disorder.,2024,10.1038/s41598-024-57942-x,https://pubmed.ncbi.nlm.nih.gov/38649688/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,31068362,Csmd2 Is a Synaptic Transmembrane Protein that Interacts with PSD-95 and Is Required for Neuronal Maturation.,2019,10.1523/eneuro.0434-18.2019,https://pubmed.ncbi.nlm.nih.gov/31068362/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,38259468,Pharmacogenomics of intravenous immunoglobulin response in Kawasaki disease.,2023,10.3389/fimmu.2023.1287094,https://pubmed.ncbi.nlm.nih.gov/38259468/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,38442557,Long-read sequencing unveils novel somatic variants and methylation patterns in the genetic information system of early lung cancer.,2024,10.1016/j.compbiomed.2024.108174,https://pubmed.ncbi.nlm.nih.gov/38442557/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,35710421,HBV genome-enriched single cell sequencing revealed heterogeneity in HBV-driven hepatocellular carcinoma (HCC).,2022,10.1186/s12920-022-01264-2,https://pubmed.ncbi.nlm.nih.gov/35710421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,37287303,In silico Screening and Validation of Achyranthes aspera as a Potential Inhibitor of BRAF and NRAS in Controlling Thyroid Cancer.,2023,10.2174/1871520623666230607125258,https://pubmed.ncbi.nlm.nih.gov/37287303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,33557409,Characterization of Hepatitis B Virus Integrations Identified in Hepatocellular Carcinoma Genomes.,2021,10.3390/v13020245,https://pubmed.ncbi.nlm.nih.gov/33557409/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,32190687,Identification of Long Noncoding RNAs as Predictors of Survival in Triple-Negative Breast Cancer Based on Network Analysis.,2020,10.1155/2020/8970340,https://pubmed.ncbi.nlm.nih.gov/32190687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,32801780,The Somatic Mutation Landscape and RNA Prognostic Markers in Stomach Adenocarcinoma.,2020,10.2147/ott.s263733,https://pubmed.ncbi.nlm.nih.gov/32801780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,35721735,"Genome-Wide Placental Gene Methylations in Gestational Diabetes Mellitus, Fetal Growth and Metabolic Health Biomarkers in Cord Blood.",2022,10.3389/fendo.2022.875180,https://pubmed.ncbi.nlm.nih.gov/35721735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,32509169,Circular RNA profile of acute myeloid leukaemia indicates circular RNA annexin A2 as a potential biomarker and therapeutic target for acute myeloid leukaemia.,2020,,https://pubmed.ncbi.nlm.nih.gov/32509169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,32065787,Novel somatic alterations underlie Chinese papillary thyroid carcinoma.,2020,10.3233/cbm-191200,https://pubmed.ncbi.nlm.nih.gov/32065787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,34168209,Molecular alterations in basal cell carcinoma subtypes.,2021,10.1038/s41598-021-92592-3,https://pubmed.ncbi.nlm.nih.gov/34168209/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,30453668,Genome-Wide Scan for Copy Number Alteration Association with Relapse-Free Survival in Colorectal Cancer with Liver Metastasis Patients.,2018,10.3390/jcm7110446,https://pubmed.ncbi.nlm.nih.gov/30453668/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,25863124,Expression and clinical significance of genes frequently mutated in small cell lung cancers defined by whole exome/RNA sequencing.,2015,10.1093/carcin/bgv026,https://pubmed.ncbi.nlm.nih.gov/25863124/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,12906867,Identification of two new members of the CSMD gene family.,2003,10.1016/s0888-7543(03)00149-6,https://pubmed.ncbi.nlm.nih.gov/12906867/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD2,ENSG00000121904,Unsafe,11572484,Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.,2001,10.1093/dnares/8.4.179,https://pubmed.ncbi.nlm.nih.gov/11572484/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,42474078,Identifying a Csmd3&lt;sup&gt;+&lt;/sup&gt; Microglial Subpopulation that Drives Cold-to-Hot Transition and Immune-Cure in Glioblastoma.,2026,10.1002/advs.76690,https://pubmed.ncbi.nlm.nih.gov/42474078/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,42724489,Genetic insights into lung squamous cell carcinoma: how &lt;i&gt;TP53&lt;/i&gt; and &lt;i&gt;CSMD3&lt;/i&gt; co-mutations shape prognosis and immune response.,2026,10.21037/tcr-2026-1534,https://pubmed.ncbi.nlm.nih.gov/42724489/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,40632521,"Variants in CSMD2 and CSMD3, genes involved in synaptogenesis, are associated with epilepsies.",2025,10.1111/epi.18539,https://pubmed.ncbi.nlm.nih.gov/40632521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,41826712,Genetic basis of the circle of Willis characteristics in the healthy and intracranial aneurysm population.,2026,10.1038/s41431-026-02079-w,https://pubmed.ncbi.nlm.nih.gov/41826712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,42327582,Development and Validation of an m6A-Derived Prognostic Signature in Lung Adenocarcinoma.,2026,10.7150/jca.134792,https://pubmed.ncbi.nlm.nih.gov/42327582/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,42139280,DNA Copy Number Profiling in Extracellular Vesicles as Clinical Biomarkers of High-Grade Serous Ovarian Carcinoma.,2026,10.1002/jev2.70308,https://pubmed.ncbi.nlm.nih.gov/42139280/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,42286854,Unveiling Candidate Markers for Drug Resistance or Synthetic Lethality in Cervical Cancer: Integrative Analysis of Genetic and Pharmacoprofiling.,2026,10.1002/cnr2.70599,https://pubmed.ncbi.nlm.nih.gov/42286854/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,41772623,Prognostic significance of genes associated with disulfidptosis in lung squamous cell carcinoma.,2026,10.1186/s13019-026-03920-5,https://pubmed.ncbi.nlm.nih.gov/41772623/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,41892355,Modeling Chronic BaP Exposure in Bronchial Epithelial Cells Reveals Multi-Scale Drivers of Early Preneoplastic Reprogramming.,2026,10.3390/cells15060566,https://pubmed.ncbi.nlm.nih.gov/41892355/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,40569942,Whole genome sequencing revealed esophageal squamous cell carcinoma related biomarkers.,2025,10.1371/journal.pone.0323915,https://pubmed.ncbi.nlm.nih.gov/40569942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,40393104,Loss of Asxl1 disrupts telencephalic midline integrity through dysregulation of SIX3 target genes.,2025,10.1016/j.bbrc.2025.152039,https://pubmed.ncbi.nlm.nih.gov/40393104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,41428143,Hepatoid adenocarcinoma of the stomach and non-hepatoid alpha-fetoprotein-producing gastric cancer exhibit a high degree of molecular similarity.,2025,10.1007/s13402-025-01145-7,https://pubmed.ncbi.nlm.nih.gov/41428143/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,40293562,Gene mutations and differentiation in laryngeal and pharyngeal squamous cell carcinoma.,2025,10.1007/s12672-025-02407-4,https://pubmed.ncbi.nlm.nih.gov/40293562/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,42192936,A Ten-Gene Transcriptomic Biomarker Panel for Glioma Classification and Prognosis Identified via Integrative Hypergraph and Rough Set Analysis.,2026,10.3390/cancers18101576,https://pubmed.ncbi.nlm.nih.gov/42192936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,41324770,Whole-exome sequencing for identification of specific gene mutations in an Indian cohort of triple-negative breast cancer patients.,2025,10.1007/s12672-025-03921-1,https://pubmed.ncbi.nlm.nih.gov/41324770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,42443809,Distinct genomic landscape of colorectal signet ring cell carcinoma reveals frequent KMT2 family alterations and SMAD4 inactivation.,2026,10.1186/s12885-026-16528-8,https://pubmed.ncbi.nlm.nih.gov/42443809/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,37037606,CSMD3 Deficiency Leads to Motor Impairments and Autism-Like Behaviors via Dysfunction of Cerebellar Purkinje Cells in Mice.,2023,10.1523/jneurosci.1835-22.2023,https://pubmed.ncbi.nlm.nih.gov/37037606/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,38067373,Integrated Genomic Analysis of Primary Prostate Tumor Foci and Corresponding Lymph Node Metastases Identifies Mutations and Pathways Associated with Metastasis.,2023,10.3390/cancers15235671,https://pubmed.ncbi.nlm.nih.gov/38067373/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,42416131,Adenosine Pathway-Based Prognostic Signature for Predicting Clinical Outcomes and Immune Microenvironment Characteristics in Epithelial Ovarian Cancer.,2026,10.14744/cpr.2026.51733,https://pubmed.ncbi.nlm.nih.gov/42416131/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,41419500,Integrating multi-omics and clinical features to model survival in epithelial ovarian cancer subtypes.,2025,10.1038/s41598-025-29403-6,https://pubmed.ncbi.nlm.nih.gov/41419500/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,38659199,"MOICS, a novel classier deciphering immune heterogeneity and aid precise management of clear cell renal cell carcinoma at multiomics level.",2024,10.1080/15384047.2024.2345977,https://pubmed.ncbi.nlm.nih.gov/38659199/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,39413743,Identification of Immune-Related Gene Signature Model for Predicting Lung Cancer Survival and Response to Immunotherapy.,2025,10.1159/000541990,https://pubmed.ncbi.nlm.nih.gov/39413743/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,32613071,Sustained response to pembrolizumab without prior chemotherapy in high-grade serous ovarian carcinoma with CSMD3 mutation.,2020,10.1016/j.gore.2020.100600,https://pubmed.ncbi.nlm.nih.gov/32613071/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,34764678,CSMD3 is Associated with Tumor Mutation Burden and Immune Infiltration in Ovarian Cancer Patients.,2021,10.2147/ijgm.s335592,https://pubmed.ncbi.nlm.nih.gov/34764678/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,38166691,Screening of novel tumor-associated antigens for lung adenocarcinoma mRNA vaccine development based on pyroptosis phenotype genes.,2024,10.1186/s12885-023-11757-7,https://pubmed.ncbi.nlm.nih.gov/38166691/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,40374631,Novel germline and somatic variants in familial and sporadic meningioma genes.,2025,10.1038/s41525-025-00494-4,https://pubmed.ncbi.nlm.nih.gov/40374631/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,12943675,A novel giant gene CSMD3 encoding a protein with CUB and sushi multiple domains: a candidate gene for benign adult familial myoclonic epilepsy on human chromosome 8q23.3-q24.1.,2003,10.1016/s0006-291x(03)01555-9,https://pubmed.ncbi.nlm.nih.gov/12943675/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSMD3,ENSG00000164796,Unsafe,11572484,Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.,2001,10.1093/dnares/8.4.179,https://pubmed.ncbi.nlm.nih.gov/11572484/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,42651887,"The &lt;i&gt;Bovidae CSN2 Locus&lt;/i&gt; as a Multilayered Evolutionary System: Evidence from Retroposons, Trans-Species Variation and Ancient Recombination.",2026,10.3390/ani16162482,https://pubmed.ncbi.nlm.nih.gov/42651887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,42508477,Hybrid transcriptome sequencing uncovers widespread shifts in transcript usage between midlactation and dry-off in goats.,2026,10.3168/jds.2026-28562,https://pubmed.ncbi.nlm.nih.gov/42508477/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,42088988,An ARMS-integrated high-resolution melting assay for reliable discrimination of the A1/A2 polymorphism in the bovine &lt;i&gt;CSN2&lt;/i&gt; gene.,2026,10.1016/j.fochms.2026.100404,https://pubmed.ncbi.nlm.nih.gov/42088988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,42528265,Exploratory identification of coding and splicing-related SNV variants in A1A1 and A2A2 β-casein Holstein dairy cows.,2026,10.1093/jas/skag233,https://pubmed.ncbi.nlm.nih.gov/42528265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,39414025,The Human Milk-derived Peptide Drives Rapid Regulation of Macrophage Inflammation Responses in the Neonatal Intestine.,2025,10.1016/j.jcmgh.2024.101420,https://pubmed.ncbi.nlm.nih.gov/39414025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,41514974,Interaction of OsCSN2 with OsCULs Under Red and Far-Red Light Regulates Stem and Coleoptile Growth in Rice.,2025,10.3390/plants15010028,https://pubmed.ncbi.nlm.nih.gov/41514974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,42278086,Genome-Wide Association Studies of Milk Composition Traits in Holstein Cattle Raised in Tropical and Subtropical Conditions.,2026,10.3390/ani16111652,https://pubmed.ncbi.nlm.nih.gov/42278086/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,41828949,Reproductive Neutrality of the A2 &lt;i&gt;β&lt;/i&gt;-Casein Variant in Holstein Cows.,2026,10.3390/ani16050741,https://pubmed.ncbi.nlm.nih.gov/41828949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,42464414,Single-nucleus RNA sequencing reveals cell type-specific responses to heat stress in bovine mammary gland.,2026,10.1186/s40104-026-01468-x,https://pubmed.ncbi.nlm.nih.gov/42464414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,42655819,Genetic Determinants of Milk Production Phenotypes in Dairy Goats: A Review.,2026,10.3390/vetsci13080799,https://pubmed.ncbi.nlm.nih.gov/42655819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,42260635,UniSePT: an engineered broadly applicable Unique Secretory signal PepTide for high-yield biotherapeutic production in mammalian cell-based expression systems.,2026,10.1186/s13036-026-00704-2,https://pubmed.ncbi.nlm.nih.gov/42260635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,42187776,Heat Stress Effects on Milk Production and the Genomic Architecture of Thermotolerance in Dairy Cattle.,2026,10.3390/biology15100813,https://pubmed.ncbi.nlm.nih.gov/42187776/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,42001153,Biological effects of orotic acid on ovine mammary epithelial cells and associated regulatory pathways study by transcriptomics.,2026,10.1186/s12917-026-05473-0,https://pubmed.ncbi.nlm.nih.gov/42001153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,42188943,β-Casein Polymorphism as a Potential Evolutionary Trade-Off: The Rise of A1 Under Intensive Selection and Its Implications for Gastrointestinal Tolerance and Agroecological Resilience.,2026,10.3390/vetsci13050473,https://pubmed.ncbi.nlm.nih.gov/42188943/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,42666800,Molecular characterization and functional analysis of buffalo prolactin (PRL) in mammary gland development and lactation.,2025,10.5194/aab-68-703-2025,https://pubmed.ncbi.nlm.nih.gov/42666800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,40943529,β-Casein A1 and A2 Genetic Variants and β-Casomorphin-7 in Raw Milk and Processed Milk Products.,2025,10.3390/ijms26178612,https://pubmed.ncbi.nlm.nih.gov/40943529/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,42088853,Shaping Cell Identity: Global Transcriptome and Pathway Shifts during Mouse Mammary Epithelial Cell Differentiation.,2026,10.34133/csbj.0055,https://pubmed.ncbi.nlm.nih.gov/42088853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,41373007,Development of a high-yield Rabbit line for enhanced animal pharming.,2025,10.1186/s40659-025-00653-y,https://pubmed.ncbi.nlm.nih.gov/41373007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,40108665,Establishment and characterization study of ovine mammary organoids.,2025,10.1186/s12917-025-04657-4,https://pubmed.ncbi.nlm.nih.gov/40108665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,42641874,Multi-species Comparative Analysis Identifies Conserved Enhancers for Improving Casein Expression via Gene Editing.,2026,10.3168/jds.2026-28604,https://pubmed.ncbi.nlm.nih.gov/42641874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,41271984,Study on strength and ultrasonic pulse velocity of cemented aeolian sand backfill under multiple factors using response surface method.,2025,10.1038/s41598-025-25288-7,https://pubmed.ncbi.nlm.nih.gov/41271984/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,40136510,Druggable Molecular Networks in &lt;i&gt;BRCA1/BRCA2&lt;/i&gt;-Mutated Breast Cancer.,2025,10.3390/biology14030253,https://pubmed.ncbi.nlm.nih.gov/40136510/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,41613207,Association of β-casein gene polymorphism with milk production characteristics in Holstein cows.,2025,10.3168/jdsc.2025-0746,https://pubmed.ncbi.nlm.nih.gov/41613207/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,38454850,"Chandelier-assisted scleral buckle surgery - contact versus non-contact wide-angle viewing system (CAB-CNV): A retrospective, multicenter, clinical study.",2024,10.4103/ijo.ijo_2820_23,https://pubmed.ncbi.nlm.nih.gov/38454850/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,41097212,Dynamic Variations in Endogenous Peptides in Chinese Human Milk Across Lactation and Geographical Regions.,2025,10.3390/nu17193131,https://pubmed.ncbi.nlm.nih.gov/41097212/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,40710576,EM Dipeptide Enhances Milk Protein Secretion: Evidence from Integrated Metabolomic and Transcriptomic Analysis.,2025,10.3390/metabo15070476,https://pubmed.ncbi.nlm.nih.gov/40710576/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,38927247,Genetically Engineered Goats as Efficient Mammary Gland Bioreactors for Production of Recombinant Human Neutrophil Peptide 1 Using CRISPR/Cas9.,2024,10.3390/biology13060367,https://pubmed.ncbi.nlm.nih.gov/38927247/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,35578669,RSM analysis based cloud access security broker: a systematic literature review.,2022,10.1007/s10586-022-03598-z,https://pubmed.ncbi.nlm.nih.gov/35578669/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,40808559,Protection of bovine mammary epithelial cells against lipopolysaccharide-induced inflammatory responses using Centella asiatica through its antioxidant and anti-inflammatory activities.,2025,10.5713/ab.25.0089,https://pubmed.ncbi.nlm.nih.gov/40808559/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,41257555,Comparative histomorphometric and transcriptomic analysis reveals potential genetic determinants of pelage variation between hairy and coarse-woolly sheep.,2025,10.1186/s12864-025-12260-y,https://pubmed.ncbi.nlm.nih.gov/41257555/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,39940662,Genomic Tools for Medicinal Properties of Goat Milk for Cosmetic and Health Benefits: A Narrative Review.,2025,10.3390/ijms26030893,https://pubmed.ncbi.nlm.nih.gov/39940662/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,37830164,The variation in the beta-casein genotypes and its effect on milk yield and genomic values in Holstein-Friesian cows.,2023,10.1080/10495398.2023.2267614,https://pubmed.ncbi.nlm.nih.gov/37830164/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,39063078,Whole-Genome Resequencing Analysis of the Camelus bactrianus (Bactrian Camel) Genome Identifies Mutations and Genes Affecting Milk Production Traits.,2024,10.3390/ijms25147836,https://pubmed.ncbi.nlm.nih.gov/39063078/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,41023035,Transcriptomic profiling of milk fat globules in cows with different β-casein genotypes.,2025,10.1038/s41598-025-17503-2,https://pubmed.ncbi.nlm.nih.gov/41023035/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,38328368,The implications of various gene variant combinations on breeding values for Awassi ewe milk production.,2023,10.14202/vetworld.2023.2411-2415,https://pubmed.ncbi.nlm.nih.gov/38328368/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,39684845,Phenylalanine Regulates Milk Protein Synthesis via LAT1-mTOR Signaling Pathways in Bovine Mammary Epithelial Cells.,2024,10.3390/ijms252313135,https://pubmed.ncbi.nlm.nih.gov/39684845/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN2,ENSG00000135222,Unsafe,39596686,"S100A9 Affects Milk Protein Content by Regulating Amino Acid Transporters and the PI3K-Akt, WNT, and mTOR Signaling Pathways.",2024,10.3390/genes15111486,https://pubmed.ncbi.nlm.nih.gov/39596686/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,42445438,CSN3 promotes gastric cancer progression and is associated with immune infiltration and inflammatory signaling.,2026,10.21037/tcr-2026-1-0141,https://pubmed.ncbi.nlm.nih.gov/42445438/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,42670798,"Dauriporphine Suppresses Cell Proliferation, Metastasis, and Stemness of Non-Small Cell Lung Cancer Through the Regulation of the USP7/CASK.",2026,10.1002/ddr.70373,https://pubmed.ncbi.nlm.nih.gov/42670798/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,42821034,CSN3 promotes colorectal cancer cell progression through activation of the PI3K/AKT/mTOR pathway.,2026,10.1007/s11033-026-12825-4,https://pubmed.ncbi.nlm.nih.gov/42821034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,41919243,Identification and validation of the potential therapeutic value of CASK in osteosarcoma: a computational analysis and &lt;i&gt;in vitro&lt;/i&gt; experiments.,2026,10.3389/fonc.2026.1693570,https://pubmed.ncbi.nlm.nih.gov/41919243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,42106797,"CASK promotes non-small cell lung cancer growth through coordinated regulation of EGFR expression, trafficking, and p21 expression.",2026,10.1186/s12929-026-01252-z,https://pubmed.ncbi.nlm.nih.gov/42106797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,42517139,Clinical heterogeneity and diagnostic challenges in &lt;i&gt;CASK&lt;/i&gt;-related neurodevelopmental disorders: a longitudinal observational study.,2026,10.3389/fpsyt.2026.1804756,https://pubmed.ncbi.nlm.nih.gov/42517139/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,41831576,Cerebellar hypoplasia caused by calcium/calmodulin-dependent serine protein kinase deficiency.,2026,10.1016/j.mocell.2026.100347,https://pubmed.ncbi.nlm.nih.gov/41831576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,42731989,PQBP1-dependent alternative RNA splicing underlies high calorie diet-induced cognitive impairment.,2026,10.1038/s41380-026-03868-x,https://pubmed.ncbi.nlm.nih.gov/42731989/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,42382379,Focal Polycomb-Mediated Repression of Neuronal Identity and Synaptic Maintenance Genes in Aging Neurons.,2026,10.7759/cureus.111824,https://pubmed.ncbi.nlm.nih.gov/42382379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,40422238,The Competitive Loss of Cerebellar Granule and Purkinje Cells Driven by X-Linked Mosaicism in a Female Mouse Model of CASK-Related Disorders.,2025,10.3390/cells14100735,https://pubmed.ncbi.nlm.nih.gov/40422238/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,42106849,Integrated methylome-transcriptome profiling reveals epigenetic regulation of immune activation pathways and CSN3-associated lactation repression in bovine subclinical mastitis.,2026,10.1186/s40104-026-01400-3,https://pubmed.ncbi.nlm.nih.gov/42106849/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,40422253,Jun N-Terminal Kinase Inhibitor Suppresses CASK Deficiency-Induced Cerebellar Granular Cell Death in MICPCH Syndrome Model Mice.,2025,10.3390/cells14100750,https://pubmed.ncbi.nlm.nih.gov/40422253/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,41321276,Patient-Derived Variants Define Constraints for Ligand Binding at the PDZ Domain of CASK.,2025,10.1111/jnc.70303,https://pubmed.ncbi.nlm.nih.gov/41321276/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,42891761,Effects of Finasteride exposure on lifespan and locomotor phenotypes.,2026,10.1007/s10522-026-10529-7,https://pubmed.ncbi.nlm.nih.gov/42891761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,42367460,Intellectual Disability and Microcephaly With Pontine and Cerebellar Hypoplasia in Adults: Severity Spectrum and Diversity of the CASK Gene Aberrations.,2026,10.7759/cureus.109777,https://pubmed.ncbi.nlm.nih.gov/42367460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,42291115,&lt;i&gt;CSN1S1&lt;/i&gt; and &lt;i&gt;CSN3&lt;/i&gt; genetic variants affect milk quality traits in the buffalo population in Serbia.,2026,10.5187/jast.2024.e78,https://pubmed.ncbi.nlm.nih.gov/42291115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,42070398,Whose wine is it anyway? Examining private label cask wine ownership among Australian alcohol retailers.,2026,10.1016/j.drugpo.2026.105300,https://pubmed.ncbi.nlm.nih.gov/42070398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,41039189,The neurodevelopmental spectrum of CASK-related disorder.,2025,10.1186/s11689-025-09643-3,https://pubmed.ncbi.nlm.nih.gov/41039189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,42065246,Helicobacter pylori-induced PPFIA4 orchestrates immune network-promoting gastritis and gastric bacterial colonization.,2026,10.1172/jci193848,https://pubmed.ncbi.nlm.nih.gov/42065246/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,42508477,Hybrid transcriptome sequencing uncovers widespread shifts in transcript usage between midlactation and dry-off in goats.,2026,10.3168/jds.2026-28562,https://pubmed.ncbi.nlm.nih.gov/42508477/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,40218442,Zearalenone Depresses Lactation Capacity Through the ROS-Mediated PI3K/AKT Pathway.,2025,10.3390/ani15071050,https://pubmed.ncbi.nlm.nih.gov/40218442/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,42426044,Simulation and experimental validation of spent nuclear fuel cask shields.,2026,10.1038/s41598-026-60071-2,https://pubmed.ncbi.nlm.nih.gov/42426044/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,42073268,Migration of Diethyl-Hexyl-Phthalate from Plastic Containers and Oak Casks to Tequila During Long-Term Storage and Aging.,2026,10.3390/foods15081380,https://pubmed.ncbi.nlm.nih.gov/42073268/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,41449476,Perceived carer skills and psychological distress in fathers and mothers of adults with anorexia nervosa: a longitudinal study.,2025,10.1186/s40337-025-01509-2,https://pubmed.ncbi.nlm.nih.gov/41449476/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,41875840,Evaluating global dry storage cask designs: Insights for APR1400 spent fuel in challenging UAE conditions.,2026,10.1016/j.jenvrad.2026.107965,https://pubmed.ncbi.nlm.nih.gov/41875840/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,39850902,Regulation of interferon alpha production by the MAGUK-family protein CASK under H5N1 infection.,2024,10.3389/fimmu.2024.1513713,https://pubmed.ncbi.nlm.nih.gov/39850902/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,42140909,The development of FEDUPP: feeding experimentation device users processing package to assess learning and cognitive flexibility.,2026,10.1038/s41398-026-04091-6,https://pubmed.ncbi.nlm.nih.gov/42140909/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,42812289,A discovery plasma proteome signature in military personnel with chronic PTSD symptoms.,2026,10.3389/fpsyt.2026.1898600,https://pubmed.ncbi.nlm.nih.gov/42812289/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,39393266,Interleukin-12 treatment reduces tumor growth and modulates the expression of CASKA and MIR-203 in athymic mice bearing tumors induced by the HGC-27 gastric cancer cell line.,2024,10.1016/j.prp.2024.155625,https://pubmed.ncbi.nlm.nih.gov/39393266/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,40481029,Comprehensive analysis of cuproptosis and m6A-Target gene signatures for diagnostic significance and immune microenvironment characterization in polycystic ovary syndrome.,2025,10.1038/s41598-025-03396-8,https://pubmed.ncbi.nlm.nih.gov/40481029/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,38328368,The implications of various gene variant combinations on breeding values for Awassi ewe milk production.,2023,10.14202/vetworld.2023.2411-2415,https://pubmed.ncbi.nlm.nih.gov/38328368/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,39598692,Chemical and Sensory Profile of Grape Distillates Aged in Quercus alba Casks Previously Used for Sherry Wine or Brandy.,2024,10.3390/molecules29225303,https://pubmed.ncbi.nlm.nih.gov/39598692/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,37099597,Casein kinase 1 gamma regulates oxidative stress response via interacting with the NADPH dual oxidase complex.,2023,10.1371/journal.pgen.1010740,https://pubmed.ncbi.nlm.nih.gov/37099597/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSN3,ENSG00000171209,Unsafe,40710576,EM Dipeptide Enhances Milk Protein Secretion: Evidence from Integrated Metabolomic and Transcriptomic Analysis.,2025,10.3390/metabo15070476,https://pubmed.ncbi.nlm.nih.gov/40710576/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,42054652,Detection of Interpretable and Fine-Grained Brain Tumor Magnetic Resonance Imaging Based on Progressive Pruning: Machine Learning Model Development and Validation Study.,2026,10.2196/84095,https://pubmed.ncbi.nlm.nih.gov/42054652/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,40898267,A CSPP1 variant associated with metabolic dysfunction in Joubert syndrome: a case report.,2025,10.1186/s13256-025-05332-w,https://pubmed.ncbi.nlm.nih.gov/40898267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,42059610,Trehalose improves cold tolerance of &lt;i&gt;Pediococcus pentosaceus&lt;/i&gt; OL77 and enhances low-temperature oat silage fermentation.,2026,10.1128/msphere.00169-26,https://pubmed.ncbi.nlm.nih.gov/42059610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,41601671,Multi-omics integration identifies NK cell dysregulation and a five-gene diagnostic signature in major depressive disorder.,2025,10.3389/fimmu.2025.1700629,https://pubmed.ncbi.nlm.nih.gov/41601671/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,41461686,Developing a new prevention model for pediatric respiratory infection.,2025,10.1038/s41598-025-28421-8,https://pubmed.ncbi.nlm.nih.gov/41461686/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,38389254,CSPP1 stabilizes microtubules by capping both plus and minus ends.,2024,10.1093/jmcb/mjae007,https://pubmed.ncbi.nlm.nih.gov/38389254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,38586154,Novel compound heterozygous variants in the CSPP1 gene causes Joubert syndrome: case report and literature review of the CSPP1 gene's pathogenic mechanism.,2024,10.3389/fped.2024.1305754,https://pubmed.ncbi.nlm.nih.gov/38586154/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,39856351,A network of interacting ciliary tip proteins with opposing activities imparts slow and processive microtubule growth.,2025,10.1038/s41594-025-01483-y,https://pubmed.ncbi.nlm.nih.gov/39856351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,38772741,CSPP1 preserves quiescent microtubule functions by dual-end capping.,2024,10.1093/jmcb/mjae022,https://pubmed.ncbi.nlm.nih.gov/38772741/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,40805721,"Combining Stable Isotope Labeling and Candidate Substrate-Product Pair Networks Reveals Lignan, Oligolignol, and Chicoric Acid Biosynthesis in Flax Seedlings (&lt;i&gt;Linum usitatissimum&lt;/i&gt; L.).",2025,10.3390/plants14152371,https://pubmed.ncbi.nlm.nih.gov/40805721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,35832625,Identifies microtubule-binding protein &lt;i&gt;CSPP1&lt;/i&gt; as a novel cancer biomarker associated with ferroptosis and tumor microenvironment.,2022,10.1016/j.csbj.2022.06.046,https://pubmed.ncbi.nlm.nih.gov/35832625/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,41982041,Long-Term Voice Outcomes After Trans-Oral Resection of Early Glottis Carcinoma.,2026,10.1002/lary.70561,https://pubmed.ncbi.nlm.nih.gov/41982041/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,37722005,Circular RNA CSPP1 motivates renal cell carcinoma carcinogenesis and the Warburg effect by targeting RAC1 through microRNA-493-5p.,2023,10.18388/abp.2020_6299,https://pubmed.ncbi.nlm.nih.gov/37722005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,36752787,CSPP1 stabilizes growing microtubule ends and damaged lattices from the luminal side.,2023,10.1083/jcb.202208062,https://pubmed.ncbi.nlm.nih.gov/36752787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,41745727,Aflatoxin and Liver Cancer in China: The Evolving Research Landscape.,2026,10.3390/toxins18020061,https://pubmed.ncbi.nlm.nih.gov/41745727/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,31651332,Proteomic alterations underlie an association with teratozoospermia in obese mice sperm.,2019,10.1186/s12958-019-0530-7,https://pubmed.ncbi.nlm.nih.gov/31651332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,35488239,Emerging role of circular RNAs in the pathogenesis of ovarian cancer.,2022,10.1186/s12935-022-02602-1,https://pubmed.ncbi.nlm.nih.gov/35488239/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,26241740,CSPP-L Associates with the Desmosome of Polarized Epithelial Cells and Is Required for Normal Spheroid Formation.,2015,10.1371/journal.pone.0134789,https://pubmed.ncbi.nlm.nih.gov/26241740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,34124372,Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis.,2021,10.1515/biol-2021-0053,https://pubmed.ncbi.nlm.nih.gov/34124372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,36276656,CSPP-IQA: a multi-scale spatial pyramid pooling-based approach for blind image quality assessment.,2022,10.1007/s00521-022-07874-2,https://pubmed.ncbi.nlm.nih.gov/36276656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,42623625,A Qualitative Analysis on the Implementation of a Community-Based Free Sunscreen Dispenser Program.,2026,,https://pubmed.ncbi.nlm.nih.gov/42623625/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,32514247,Circular RNA circ-CSPP1 regulates CCNE2 to facilitate hepatocellular carcinoma cell growth via sponging miR-577.,2020,10.1186/s12935-020-01287-8,https://pubmed.ncbi.nlm.nih.gov/32514247/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,35578692,A Novel Inflammation-Related Gene Signature for Overall Survival Prediction and Comprehensive Analysis in Pediatric Patients with Wilms Tumor.,2022,10.1155/2022/2651105,https://pubmed.ncbi.nlm.nih.gov/35578692/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,29742019,The E3 ubiquitin ligase UBR5 regulates centriolar satellite stability and primary cilia.,2018,10.1091/mbc.e17-04-0248,https://pubmed.ncbi.nlm.nih.gov/29742019/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,27187530,Ensembles of adaptive spatial filters increase BCI performance: an online evaluation.,2016,10.1088/1741-2560/13/4/046003,https://pubmed.ncbi.nlm.nih.gov/27187530/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,26378239,Mitotic Protein CSPP1 Interacts with CENP-H Protein to Coordinate Accurate Chromosome Oscillation in Mitosis.,2015,10.1074/jbc.m115.658534,https://pubmed.ncbi.nlm.nih.gov/26378239/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,24494979,The absence of CpG in plasmid DNA-chitosan polyplexes enhances transfection efficiencies and reduces inflammatory responses in murine lungs.,2014,10.1021/mp400689r,https://pubmed.ncbi.nlm.nih.gov/24494979/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,30155197,A red-emissive antibody-AIEgen conjugate for turn-on and wash-free imaging of specific cancer cells.,2017,10.1039/c7sc01054k,https://pubmed.ncbi.nlm.nih.gov/30155197/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,30859394,Detection of Protein Toxin Simulants from Contaminated Surfaces by Paper Spray Mass Spectrometry.,2019,10.1007/s13361-019-02141-6,https://pubmed.ncbi.nlm.nih.gov/30859394/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,25261832,Cold stress improves the ability of Lactobacillus plantarum L67 to survive freezing.,2014,10.1016/j.ijfoodmicro.2014.09.017,https://pubmed.ncbi.nlm.nih.gov/25261832/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,20936670,Secretion of human superoxide dismutase in Escherichia coli using the condensed single-protein-production system.,2010,10.1002/pro.512,https://pubmed.ncbi.nlm.nih.gov/20936670/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,19830594,The E. coli single protein production system for production and structural analysis of membrane proteins.,2010,10.1007/s10969-009-9070-2,https://pubmed.ncbi.nlm.nih.gov/19830594/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,9139925,"Cloning and characterization of cspL and cspP, two cold-inducible genes from Lactobacillus plantarum.",1997,10.1128/jb.179.9.3039-3042.1997,https://pubmed.ncbi.nlm.nih.gov/9139925/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,24360807,Mutations in CSPP1 lead to classical Joubert syndrome.,2014,10.1016/j.ajhg.2013.11.015,https://pubmed.ncbi.nlm.nih.gov/24360807/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CSPP1,ENSG00000104218,Unsafe,15580290,Identification of a novel centrosome/microtubule-associated coiled-coil protein involved in cell-cycle progression and spindle organization.,2005,10.1038/sj.onc.1208267,https://pubmed.ncbi.nlm.nih.gov/15580290/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A1,ENSG00000268940,Unsafe,37924456,Cancer/testis-45A1 promotes cervical cancer cell tumorigenesis and drug resistance by activating oncogenic SRC and downstream signaling pathways.,2024,10.1007/s13402-023-00891-w,https://pubmed.ncbi.nlm.nih.gov/37924456/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A1,ENSG00000268940,Unsafe,39322998,"CT45A1-mediated MLC2 (MYL9) phosphorylation promotes natural killer cell resistance and outer cell fate in a cell-in-cell structure, potentiating the progression of microsatellite instability-high colorectal cancer.",2025,10.1002/1878-0261.13736,https://pubmed.ncbi.nlm.nih.gov/39322998/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A1,ENSG00000268940,Unsafe,37095619,The Cancer/Testis Antigen CT45A1 Promotes Transcription of Oncogenic Sulfatase-2 Gene in Breast Cancer Cells and Is Sensible Targets for Cancer Therapy.,2023,10.4048/jbc.2023.26.e5,https://pubmed.ncbi.nlm.nih.gov/37095619/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A1,ENSG00000268940,Unsafe,37835834,Characterization of Cancer/Testis Antigens as Prognostic Markers of Ovarian Cancer.,2023,10.3390/diagnostics13193092,https://pubmed.ncbi.nlm.nih.gov/37835834/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A1,ENSG00000268940,Unsafe,39366464,Machine learning based analysis of single-cell data reveals evidence of subject-specific single-cell gene expression profiles in acute myeloid leukaemia patients and healthy controls.,2024,10.1016/j.bbagrm.2024.195062,https://pubmed.ncbi.nlm.nih.gov/39366464/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A1,ENSG00000268940,Unsafe,34172717,CT45A1 promotes the metastasis of osteosarcoma cells in vitro and in vivo through β-catenin.,2021,10.1038/s41419-021-03935-x,https://pubmed.ncbi.nlm.nih.gov/34172717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A1,ENSG00000268940,Unsafe,28901509,"CT45A1 siRNA silencing suppresses the proliferation, metastasis and invasion of lung cancer cells by downregulating the ERK/CREB signaling pathway.",2017,10.3892/mmr.2017.7466,https://pubmed.ncbi.nlm.nih.gov/28901509/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A1,ENSG00000268940,Unsafe,24901056,CT45A1 acts as a new proto-oncogene to trigger tumorigenesis and cancer metastasis.,2014,10.1038/cddis.2014.244,https://pubmed.ncbi.nlm.nih.gov/24901056/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A1,ENSG00000268940,Unsafe,36827041,Novel diagnostic biomarkers of T cell-mediated tumor killing characteristics for early-stage triple negative breast cancer: A SEER analysis and molecular portraits.,2023,10.1097/md.0000000000033059,https://pubmed.ncbi.nlm.nih.gov/36827041/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A1,ENSG00000268940,Unsafe,35651938,Identification of Novel Characteristics in TP53-Mutant Hepatocellular Carcinoma Using Bioinformatics.,2022,10.3389/fgene.2022.874805,https://pubmed.ncbi.nlm.nih.gov/35651938/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A1,ENSG00000268940,Unsafe,33413474,Immune landscape and prognostic immune-related genes in KRAS-mutant colorectal cancer patients.,2021,10.1186/s12967-020-02638-9,https://pubmed.ncbi.nlm.nih.gov/33413474/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A1,ENSG00000268940,Unsafe,25506890,Cancer/testis antigens trigger epithelial-mesenchymal transition and genesis of cancer stem-like cells.,2015,10.2174/1381612821666141211154707,https://pubmed.ncbi.nlm.nih.gov/25506890/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A1,ENSG00000268940,Unsafe,33832322,Research progress on the molecular mechanisms of hepatic metastasis in lung cancer: a narrative review.,2021,10.21037/apm-20-1675,https://pubmed.ncbi.nlm.nih.gov/33832322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A1,ENSG00000268940,Unsafe,34528236,Transcriptomic changes during stage progression of mycosis fungoides.,2022,10.1111/bjd.20760,https://pubmed.ncbi.nlm.nih.gov/34528236/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A1,ENSG00000268940,Unsafe,32812178,Prognostication of a 13-immune-related-gene signature in patients with early triple-negative breast cancer.,2020,10.1007/s10549-020-05874-1,https://pubmed.ncbi.nlm.nih.gov/32812178/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A1,ENSG00000268940,Unsafe,23574628,"Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene.",2013,10.1111/tan.12113,https://pubmed.ncbi.nlm.nih.gov/23574628/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A1,ENSG00000268940,Unsafe,20920256,A novel spliced fusion of MLL with CT45A2 in a pediatric biphenotypic acute leukemia.,2010,10.1186/1471-2407-10-518,https://pubmed.ncbi.nlm.nih.gov/20920256/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A1,ENSG00000268940,Unsafe,15905330,Identification of cancer/testis-antigen genes by massively parallel signature sequencing.,2005,10.1073/pnas.0502583102,https://pubmed.ncbi.nlm.nih.gov/15905330/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A3,ENSG00000269096,Unsafe,40136427,Exploring the Therapeutic Potential of the DOT1L Inhibitor EPZ004777 Using Bioinformatics and Molecular Docking Approaches in Acute Myeloid Leukemia.,2025,10.3390/cimb47030173,https://pubmed.ncbi.nlm.nih.gov/40136427/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A3,ENSG00000269096,Unsafe,32885674,Identification of key factors associated with early- and late-onset ovarian serous cystadenocarcinoma.,2020,10.2217/fon-2020-0668,https://pubmed.ncbi.nlm.nih.gov/32885674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A3,ENSG00000269096,Unsafe,34528236,Transcriptomic changes during stage progression of mycosis fungoides.,2022,10.1111/bjd.20760,https://pubmed.ncbi.nlm.nih.gov/34528236/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A3,ENSG00000269096,Unsafe,15905330,Identification of cancer/testis-antigen genes by massively parallel signature sequencing.,2005,10.1073/pnas.0502583102,https://pubmed.ncbi.nlm.nih.gov/15905330/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A5,ENSG00000228836,Unsafe,40389402,Genomic and transcriptomic determinants of clinical outcomes in patients with AML and DNMT3A mutations.,2025,10.1038/s41408-025-01287-9,https://pubmed.ncbi.nlm.nih.gov/40389402/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A5,ENSG00000228836,Unsafe,15905330,Identification of cancer/testis-antigen genes by massively parallel signature sequencing.,2005,10.1073/pnas.0502583102,https://pubmed.ncbi.nlm.nih.gov/15905330/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CT45A6,ENSG00000278289,Unsafe,15905330,Identification of cancer/testis-antigen genes by massively parallel signature sequencing.,2005,10.1073/pnas.0502583102,https://pubmed.ncbi.nlm.nih.gov/15905330/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,42315649,SCP4 dephosphorylates mitotic histone H3 to maintain chromosome stability.,2026,10.1038/s44319-026-00833-1,https://pubmed.ncbi.nlm.nih.gov/42315649/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,42653391,Serum Peptidomic Analysis in a Comparative Study of the Efficacy of Benjakul Remedy Versus Loratadine in Allergic Rhinitis Patients.,2026,10.3390/ijms27167389,https://pubmed.ncbi.nlm.nih.gov/42653391/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,40352265,"The phosphatase CTDSPL2 promotes proliferation, invasion, metastasis and regorafenib resistance in osteosarcoma.",2025,10.1016/j.jbo.2025.100684,https://pubmed.ncbi.nlm.nih.gov/40352265/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,40414558,Protein phosphatase SCP4 regulates temporomandibular joint cartilage development via glucose metabolism.,2025,10.1016/j.lfs.2025.123741,https://pubmed.ncbi.nlm.nih.gov/40414558/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,39209829,CTDSPL2 promotes the progression of non-small lung cancer through PI3K/AKT signaling via JAK1.,2024,10.1038/s41420-024-02162-5,https://pubmed.ncbi.nlm.nih.gov/39209829/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,42226445,"Evaluation of Torula Yeast (Candida utilis) Single Cell Proteins as a Partial Replacement for Soybean Meal in Broiler Diets: Effects on Productive Performance, Meat Quality Traits, and Plasma Metabolome.",2026,10.1111/jpn.70082,https://pubmed.ncbi.nlm.nih.gov/42226445/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,38886174,Protein phosphatase SCP4 regulates cartilage development and endochondral osteogenesis via FoxO3a dephosphorylation.,2024,10.1111/cpr.13691,https://pubmed.ncbi.nlm.nih.gov/38886174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,40094036,A Transcriptomic Signature of Depressive Symptoms in Late Life.,2025,10.1016/j.bpsgos.2025.100448,https://pubmed.ncbi.nlm.nih.gov/40094036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,34813892,The phosphatase CTDSPL2 is phosphorylated in mitosis and a target for restraining tumor growth and motility in pancreatic cancer.,2022,10.1016/j.canlet.2021.11.018,https://pubmed.ncbi.nlm.nih.gov/34813892/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,37309586,Hypermethylation of CTDSPL2 prior to necrotizing enterocolitis onset.,2023,10.2217/epi-2023-0119,https://pubmed.ncbi.nlm.nih.gov/37309586/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,41853595,"Comprehensive profiling of volatile aroma compounds and non-volatile metabolites in five salted chili peppers using multi-omics technologies: &lt;i&gt;E&lt;/i&gt;-nose, &lt;i&gt;E&lt;/i&gt;-tongue, GC-IMS, GC × GC-TOF-MS, and UHPLC-MS/MS.",2026,10.1016/j.fochx.2026.103714,https://pubmed.ncbi.nlm.nih.gov/41853595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,35021089,SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia.,2022,10.1016/j.celrep.2021.110233,https://pubmed.ncbi.nlm.nih.gov/35021089/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,39693780,Association of exposure to second-hand smoke during childhood with blood DNA methylation.,2025,10.1016/j.envint.2024.109204,https://pubmed.ncbi.nlm.nih.gov/39693780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,29618518,C-terminal domain small phosphatase-like 2 promotes epithelial-to-mesenchymal transition via Snail dephosphorylation and stabilization.,2018,10.1098/rsob.170274,https://pubmed.ncbi.nlm.nih.gov/29618518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,28851713,SCP4 Promotes Gluconeogenesis Through FoxO1/3a Dephosphorylation.,2018,10.2337/db17-0546,https://pubmed.ncbi.nlm.nih.gov/28851713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,29263168,SCP4: A Small Nuclear Phosphatase Having a Big Effect on FoxOs in Gluconeogenesis.,2018,10.2337/dbi17-0042,https://pubmed.ncbi.nlm.nih.gov/29263168/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,26920047,Human SCP4 is a chromatin-associated CTD phosphatase and exhibits the dynamic translocation during erythroid differentiation.,2016,10.1093/jb/mvw018,https://pubmed.ncbi.nlm.nih.gov/26920047/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,26674342,A systematic study of nuclear interactome of C-terminal domain small phosphatase-like 2 using inducible expression system and shotgun proteomics.,2016,10.5483/bmbrep.2016.49.6.240,https://pubmed.ncbi.nlm.nih.gov/26674342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,28506762,The nuclear phosphatase SCP4 regulates FoxO transcription factors during muscle wasting in chronic kidney disease.,2017,10.1016/j.kint.2017.02.031,https://pubmed.ncbi.nlm.nih.gov/28506762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTDSPL2,ENSG00000137770,Unsafe,28915671,"Integration of ALV into CTDSPL and CTDSPL2 genes in B-cell lymphomas promotes cell immortalization, migration and survival.",2017,10.18632/oncotarget.19328,https://pubmed.ncbi.nlm.nih.gov/28915671/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,40859434,A Decoy Oligodeoxynucleotides Disturbing Forkhead Box O3 Mediated ctnna2 Transcriptional Repression Prevents Postoperative Neurocognitive Disorder in Mice.,2025,10.1111/cns.70454,https://pubmed.ncbi.nlm.nih.gov/40859434/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,42558421,GWAS and selection signature analyses of whole-genome sequencing data identify genes associated with body size in Duolang sheep.,2026,10.3389/fvets.2026.1869513,https://pubmed.ncbi.nlm.nih.gov/42558421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,41633955,Identification of a New Transcriptional Signature of Pre-Adipocytes in Human Subcutaneous White Adipose Tissue.,2026,10.1002/oby.70135,https://pubmed.ncbi.nlm.nih.gov/41633955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,42390169,Müller Glia-Exclusive CLRN1 Expression Drives Non-Cell-Autonomous Photoreceptor Degeneration in Usher Syndrome Type 3A.,2026,10.1167/iovs.67.8.9,https://pubmed.ncbi.nlm.nih.gov/42390169/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,41321497,Effect of chronic heat stress on duodenal epithelial barrier integrity in low- and high-water-efficient broiler chickens.,2025,10.3389/fphys.2025.1704737,https://pubmed.ncbi.nlm.nih.gov/41321497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,40619573,Tracking Hyperpolarized [1-&lt;sup&gt;13&lt;/sup&gt;C] Pyruvate and [1-&lt;sup&gt;13&lt;/sup&gt;C] L-Lactate Metabolism in the Healthy and Post-Stroke Mouse Brain.,2025,10.1002/nbm.70094,https://pubmed.ncbi.nlm.nih.gov/40619573/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,40282003,"Optimal Period of Calcium Propionate Supplementation in Arrival High-Risk Bull Calves: Growth Performance, Body Fat Reserves, and Serum Metabolites.",2025,10.3390/ani15081170,https://pubmed.ncbi.nlm.nih.gov/40282003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,40284800,"Role of Calcium Propionate and Monensin on Performance, Rumen Fermentation Patterns, and Ruminal Bacterial Populations in Growing Lambs.",2025,10.3390/vetsci12040298,https://pubmed.ncbi.nlm.nih.gov/40284800/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,39195790,"Effects of Supplemental Calcium Propionate and Concentrate Level: Growth Performance, Body Fat Reserves, and Health of High-Risk Beef Calves.",2024,10.3390/vetsci11080336,https://pubmed.ncbi.nlm.nih.gov/39195790/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,40810818,Genetic modifiers of frequent vaso-occlusive hospitalizations among individuals with sickle cell disease (SCD).,2025,10.1007/s00277-025-06547-z,https://pubmed.ncbi.nlm.nih.gov/40810818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,39376159,Genetic analysis of cognitive preservation in the midwestern Amish reveals a novel locus on chromosome 2.,2024,10.1002/alz.14045,https://pubmed.ncbi.nlm.nih.gov/39376159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,41515046,&lt;i&gt;CaGβ&lt;/i&gt; Promotes &lt;i&gt;CaWRKY40&lt;/i&gt; to Activate Immunity Against &lt;i&gt;Ralstonia solanacearum&lt;/i&gt; but Disables It from Activating Thermotolerance.,2025,10.3390/plants15010101,https://pubmed.ncbi.nlm.nih.gov/41515046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,41418531,Effect of heat stress on jejunal epithelial barrier integrity in broilers divergently selected for high- and low-water efficiency.,2026,10.1016/j.psj.2025.106292,https://pubmed.ncbi.nlm.nih.gov/41418531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,40140215,Nutritional ketosis modulates the methylation of cancer-related genes in patients with obesity and in breast cancer cells.,2025,10.1007/s13105-025-01076-9,https://pubmed.ncbi.nlm.nih.gov/40140215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,37305699,Proteogenomic landscape of gastric adenocarcinoma peritoneal metastases.,2023,10.1016/j.isci.2023.106913,https://pubmed.ncbi.nlm.nih.gov/37305699/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,41378749,Folate Interaction With Genetic Risk for Neural Tube Defects Among Infants in Bangladesh.,2025,10.1002/bdr2.70007,https://pubmed.ncbi.nlm.nih.gov/41378749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,41053030,Shift in sex and age of individuals at a clinical high risk (CHR) for psychosis: relation to differences in recruitment methods and effect on sample characteristics.,2025,10.1038/s41537-025-00663-5,https://pubmed.ncbi.nlm.nih.gov/41053030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,38117821,Effects of maternal calcium propionate supplementation on offspring productivity and meat metabolomic profile in sheep.,2023,10.1371/journal.pone.0294627,https://pubmed.ncbi.nlm.nih.gov/38117821/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,39442698,Methylome-wide association study of adolescent depressive episode with psychotic symptoms and childhood trauma.,2025,10.1016/j.jad.2024.10.029,https://pubmed.ncbi.nlm.nih.gov/39442698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,39747445,"Fortilin binds CTNNA3 and protects it against phosphorylation, ubiquitination, and proteasomal degradation to guard cells against apoptosis.",2025,10.1038/s42003-024-07399-5,https://pubmed.ncbi.nlm.nih.gov/39747445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,42562216,Polygenic risk for poor appetite or overeating and for alcohol use influence emotional eating and alcohol consumption.,2026,10.1016/j.appet.2026.108750,https://pubmed.ncbi.nlm.nih.gov/42562216/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,42287047,[Association analysis between genetic nurturing effects of &lt;i&gt;CTNNA&lt;/i&gt; gene family and ischemic stroke].,2026,10.19723/j.issn.1671-167x.2026.03.012,https://pubmed.ncbi.nlm.nih.gov/42287047/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,41829518,GDEIM-SF: A Lightweight UAV Detection Framework Coupling Dehazing and Low-Light Enhancement.,2026,10.3390/s26051557,https://pubmed.ncbi.nlm.nih.gov/41829518/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,37835718,"Effects of Duration of Calcium Propionate Supplementation in Lambs Finished with Supplemental Zilpaterol Hydrochloride: Productive Performance, Carcass Characteristics, and Meat Quality.",2023,10.3390/ani13193113,https://pubmed.ncbi.nlm.nih.gov/37835718/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,40597588,Analysis of genomic selection characteristics of local cattle breeds in Gansu.,2025,10.1186/s12864-025-11753-0,https://pubmed.ncbi.nlm.nih.gov/40597588/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,39541202,Toripalimab Plus Chemotherapy as a First-Line Therapy for Extensive-Stage Small Cell Lung Cancer: The Phase 3 EXTENTORCH Randomized Clinical Trial.,2025,10.1001/jamaoncol.2024.5019,https://pubmed.ncbi.nlm.nih.gov/39541202/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,40355455,"Increased face perception in individuals at clinical high-risk for psychosis: mechanisms, sex differences, and clinical correlates.",2025,10.1038/s41537-025-00624-y,https://pubmed.ncbi.nlm.nih.gov/40355455/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,34163353,Catenin Alpha-2 Mutation Changes the Immune Microenvironment in Lung Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitors.,2021,10.3389/fphar.2021.645862,https://pubmed.ncbi.nlm.nih.gov/34163353/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,40849429,Identifying individuals at clinical high risk for psychosis using a battery of tasks sensitive to symptom mechanisms.,2025,10.1038/s41398-025-03539-5,https://pubmed.ncbi.nlm.nih.gov/40849429/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,38867694,"An Apatite-Group Praseodymium Carbonate Fluoroxybritholite: Hydrothermal Synthesis, Crystal Structure, and Implications for Natural and Synthetic Britholites.",2024,10.1021/acs.inorgchem.4c01490,https://pubmed.ncbi.nlm.nih.gov/38867694/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,39905311,"The transcriptional response to yellow and wilt disease, caused by race 6 of Fusarium oxysporum f. sp. Ciceris in two contrasting chickpea cultivars.",2025,10.1186/s12864-025-11308-3,https://pubmed.ncbi.nlm.nih.gov/39905311/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,34307899,Computerized Assessment of Psychosis Risk.,2021,10.20900/jpbs.20210011,https://pubmed.ncbi.nlm.nih.gov/34307899/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,40036276,Being well-fed in universal school lunches in Canada: avoiding a one-size-fits-all approach.,2025,10.1093/heapro/daaf012,https://pubmed.ncbi.nlm.nih.gov/40036276/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CTNNA2,ENSG00000066032,Unsafe,30013181,"Biallelic loss of human CTNNA2, encoding αN-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migration.",2018,10.1038/s41588-018-0166-0,https://pubmed.ncbi.nlm.nih.gov/30013181/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42158148,Markers of neuroinflammation in the CSF of patients with difficult to treat psychiatric disease.,2026,10.3389/fpsyt.2026.1665447,https://pubmed.ncbi.nlm.nih.gov/42158148/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42430902,CXCL11 recruits immunosuppressive cells to form a barrier at the invasive front of pancreatic cancer by activating the NF-κB/CCL2 axis.,2026,10.1016/j.tranon.2026.102909,https://pubmed.ncbi.nlm.nih.gov/42430902/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,41645247,CXCL11 levels regulate lung Treg responses to deter the onset of HIV-related COPD.,2026,10.1186/s12931-026-03495-8,https://pubmed.ncbi.nlm.nih.gov/41645247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42192983,In-Treatment Kinetics of Peripheral Blood Immune Markers in PD-L1 High Non-Small Cell Lung Cancer and Prognostic Relevance for Immunotherapy Outcomes.,2026,10.3390/cancers18101623,https://pubmed.ncbi.nlm.nih.gov/42192983/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42588988,&lt;i&gt;Houttuynia cordata&lt;/i&gt; Extract Alleviates &lt;i&gt;SVCV&lt;/i&gt; Infection by Modulating the &lt;i&gt;RARα-A&lt;/i&gt;/Type I Interferon Axis in Common Carp.,2026,10.3390/ani16152350,https://pubmed.ncbi.nlm.nih.gov/42588988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42077068,CXCL11 secreted by cancer-associated fibroblasts promotes nasopharyngeal carcinoma progression via CXCR3/PD-L1 axis.,2026,10.1080/19336918.2026.2665498,https://pubmed.ncbi.nlm.nih.gov/42077068/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42582141,Epithelial CXCL1 tracks clinical remission in inflammatory bowel disease in a disease-specific manner.,2026,10.3389/fimmu.2026.1904951,https://pubmed.ncbi.nlm.nih.gov/42582141/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42003937,Comprehensive treatment for intracranial invasive sinonasal intestinal-type adenocarcinoma with a focus on radiotherapy dosage and immunological combination therapy: A case report.,2026,10.3892/ol.2026.15571,https://pubmed.ncbi.nlm.nih.gov/42003937/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42653185,Tear Cytokine Signature in Vernal Keratoconjunctivitis: A Chemokine-Remodeling Axis Associated with Disease Severity.,2026,10.3390/ijms27167180,https://pubmed.ncbi.nlm.nih.gov/42653185/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,41772665,Targeting lncRNA RP11-358L4.1 attenuates breast cancer cell proliferation and is associated with cell cycle and immune-related transcriptomic signatures.,2026,10.1186/s12957-026-04267-w,https://pubmed.ncbi.nlm.nih.gov/41772665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42744872,Spatial characterization of interface dermatitis in cutaneous lupus reveals novel chemokine axis-mediated recruitment of leukocytes that drive disease.,2026,10.1038/s41598-026-60937-5,https://pubmed.ncbi.nlm.nih.gov/42744872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42698624,An isogenic hiPSC-derived keratinocyte model reveals CXCL10/CXCL11 inflammatory dysregulation in epidermolysis bullosa simplex.,2026,10.3389/fcell.2026.1918694,https://pubmed.ncbi.nlm.nih.gov/42698624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42067157,"CXCL9, CXCL11, and CXCR3 mRNA expression and protein level in blood and urine of kidney transplant rejected patients.",2026,10.1016/j.trim.2026.102394,https://pubmed.ncbi.nlm.nih.gov/42067157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,41303732,"ITAC and Non-ITAC Sinonasal Adenocarcinoma: Classification, Etiopathogenesis, Diagnosis and Therapy Focusing on Interdisciplinarity.",2025,10.3390/medicina61111895,https://pubmed.ncbi.nlm.nih.gov/41303732/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,41611908,TWEAK receptor (Fn14) exacerbates TNF-α-induced inflammation in rheumatoid arthritis synovial fibroblasts and influences response to anti-TNF-α therapy.,2026,10.1038/s41423-026-01386-y,https://pubmed.ncbi.nlm.nih.gov/41611908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42587795,Adipose Dysfunction Caused by Obesity and Radiation Therapy Rewires the Prostate Stroma Toward Tumor Progression.,2026,10.3390/cells15151387,https://pubmed.ncbi.nlm.nih.gov/42587795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,40822974,Immune molecule diagnostics in colorectal cancer: CCL2 and CXCL11.,2025,10.1515/biol-2025-1147,https://pubmed.ncbi.nlm.nih.gov/40822974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42050706,Dual immunosuppression mechanism induced by PTP1B in colorectal cancer: upregulation of PD-L1 by FOXO1/miR-34C/c-MYC axis and inhibition of the infiltration of CD8(+) T cell by downregulating of CXCL11.,2026,10.1186/s12967-026-08189-9,https://pubmed.ncbi.nlm.nih.gov/42050706/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42351157,Combining Mendelian randomization and multiomics data to determine the causal relationship between systemic inflammation and head and neck squamous cell carcinoma.,2026,10.1186/s12935-026-04359-3,https://pubmed.ncbi.nlm.nih.gov/42351157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42689973,Tazarotene-Induced Gene 2 Promotes Melanoma Cell Death via the Activation of Endoplasmic Reticulum Stress.,2026,10.31083/fbl54095,https://pubmed.ncbi.nlm.nih.gov/42689973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,41547362,"Personalised multipeptide-based T-cell activator for chronic lymphocytic leukaemia: an open-label, single-centre, phase 1 study.",2026,10.1016/s2352-3026(25)00323-0,https://pubmed.ncbi.nlm.nih.gov/41547362/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42654067,Chemokine-Armed Oncolytic Viruses: Engineering Immune Cell Trafficking to Transform the Tumor Microenvironment.,2026,10.3390/pharmaceutics18080950,https://pubmed.ncbi.nlm.nih.gov/42654067/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,41623177,Unraveling TIME: CD8+ T cell- and CXCL11-driven endocrine resistance in breast cancer.,2026,10.1172/jci200923,https://pubmed.ncbi.nlm.nih.gov/41623177/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,41916730,Dual-chemokine-armed oncolytic Senecavirus A co-recruits cDC1 and CXCR3&lt;sup&gt;+&lt;/sup&gt; T cells to convert 'cold' melanoma and drive durable regression.,2026,10.1136/jitc-2025-014258,https://pubmed.ncbi.nlm.nih.gov/41916730/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42689729,Unveiling the immune microenvironment in sinonasal intestinal type adenocarcinoma: new arguments for immunotherapy.,2026,10.1080/2162402x.2026.2725500,https://pubmed.ncbi.nlm.nih.gov/42689729/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42821609,A Phase I Clinical Trial of Chemoimmunotherapy With Alternating Intravesical Gemcitabine and Bacillus Calmette-Guérin (GemBCG) for BCG-Exposed High-Grade Non-Muscle-Invasive Bladder Cancer.,2026,10.1097/ju.0000000000005324,https://pubmed.ncbi.nlm.nih.gov/42821609/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,40623115,Passive immunotherapy for adults hospitalized with COVID-19: An individual participant data meta-analysis of six randomized controlled trials.,2025,10.1371/journal.pmed.1004616,https://pubmed.ncbi.nlm.nih.gov/40623115/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42023986,Tumor-Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T-Cell Infiltration and Limiting Myeloid Cell-Mediated Immunosuppression.,2026,10.1002/advs.202523895,https://pubmed.ncbi.nlm.nih.gov/42023986/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,42344108,Comparing risk factors in severe COVID-19 using machine learning and non-machine learning methods: analysis from 2 international randomized controlled trials.,2026,10.1093/jamiaopen/ooag079,https://pubmed.ncbi.nlm.nih.gov/42344108/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,41364532,CD8+ T cells in the tumor microenvironment modulate the response to endocrine therapy in breast cancer.,2026,10.1172/jci188458,https://pubmed.ncbi.nlm.nih.gov/41364532/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,41012114,The Path Towards Effective Long-Lasting Tissue-Targeted Prime/Pull/Keep Herpes Simplex Therapeutic Vaccines.,2025,10.3390/vaccines13090908,https://pubmed.ncbi.nlm.nih.gov/41012114/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,40574841,Effect of immune infiltration intensity on the efficacy of neoadjuvant immunotherapy for esophageal cancer.,2025,10.3389/fimmu.2025.1543283,https://pubmed.ncbi.nlm.nih.gov/40574841/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXCL11,ENSG00000169248,Unsafe,41140255,Targeted DDR1 Treatment Strategy Enhances PD-1 Immunotherapy Efficacy against Gastric Cancer.,2025,10.1021/acs.jmedchem.5c02505,https://pubmed.ncbi.nlm.nih.gov/41140255/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXorf65,ENSG00000204165,Unsafe,37760841,Establishing Molecular Subgroups of CD8+ T Cell-Associated Genes in the Ovarian Cancer Tumour Microenvironment and Predicting the Immunotherapy Response.,2023,10.3390/biomedicines11092399,https://pubmed.ncbi.nlm.nih.gov/37760841/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXorf65,ENSG00000204165,Unsafe,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CXorf65,ENSG00000204165,Unsafe,35433762,Identification of an Immune Classification and Prognostic Genes for Lung Adenocarcinoma Based on Immune Cell Signatures.,2022,10.3389/fmed.2022.855387,https://pubmed.ncbi.nlm.nih.gov/35433762/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYB5RL,ENSG00000215883,Unsafe,30018743,"Collaborating genomic, transcriptomic and microbiomic alterations lead to canine extreme intestinal polyposis.",2018,10.18632/oncotarget.25646,https://pubmed.ncbi.nlm.nih.gov/30018743/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,42126596,Visualization of relative 11β-hydroxylase (CYP11B1) activity in human cortisol-producing adrenocortical adenoma (CPA) using mass spectrometry imaging-based enzyme histochemistry.,2026,10.1007/s00216-026-06518-x,https://pubmed.ncbi.nlm.nih.gov/42126596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,42196271,"The Expression of Placental 17β-Hydroxysteroid Dehydrogenase Genes Is Associated with the Elevation of Active Androgens and Estrogens in Pregnant Women, but Does Not Affect 11-Oxygenated C19 Steroids.",2026,10.3390/ijms27104290,https://pubmed.ncbi.nlm.nih.gov/42196271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,42307048,Baxdrostat versus osilodrostat: steroid biosynthesis in human adrenocortical cells.,2026,10.1530/ec-25-0807,https://pubmed.ncbi.nlm.nih.gov/42307048/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,42775908,18F-CETO in adrenocortical carcinoma: first clinical-translational study of an adrenocortical-targeting PET tracer.,2026,10.1530/erc-26-0314,https://pubmed.ncbi.nlm.nih.gov/42775908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,41360104,"Adrenal Cortical Steroidogenic Enzyme Expression is Associated with Hypertension, Obesity and Corticosteroid Use: A Tissue Microarray Study of Human Adrenal Tissue.",2025,10.1055/a-2738-2453,https://pubmed.ncbi.nlm.nih.gov/41360104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,42536251,Variant-specific contributions of CYP21A2 and CYP11B1 to the clinical and hormonal heterogeneity of polyendocrine metabolic ovarian syndrome phenotypes.,2026,10.1007/s11033-026-12498-z,https://pubmed.ncbi.nlm.nih.gov/42536251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,40739578,Nodule density on CT-scan correlates with CYP11B1 expression in a patient with ARMC5 mutated primary bilateral macronodular adrenal hyperplasia.,2025,10.1186/s13000-025-01671-w,https://pubmed.ncbi.nlm.nih.gov/40739578/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,41988370,Baxdrostat: A First-in-Class Aldosterone Synthase Inhibitor for Resistant Hypertension.,2026,10.1021/acsptsci.6c00102,https://pubmed.ncbi.nlm.nih.gov/41988370/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,40565260,lncRNA &lt;i&gt;1700009J07Rik&lt;/i&gt; Impaired Male Fertility by Interfering with Sexual Behaviors in Mice.,2025,10.3390/ijms26125801,https://pubmed.ncbi.nlm.nih.gov/40565260/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,38885296,Human Gonads Do Not Contribute to the Circulating Pool of 11-Oxygenated Androgens.,2025,10.1210/clinem/dgae420,https://pubmed.ncbi.nlm.nih.gov/38885296/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,42795360,Aldosterone Synthase Inhibitors: Emerging Therapeutic Strategies in Resistant Hypertension.,2026,10.3390/life16091495,https://pubmed.ncbi.nlm.nih.gov/42795360/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,42392716,[Therapeutic mechanism of combination of Epimedii Folium and Ligustri Lucidi Fructus for glucocorticoid synthesis-restricted asthma in rats].,2026,10.19540/j.cnki.cjcmm.20251119.801,https://pubmed.ncbi.nlm.nih.gov/42392716/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,41668506,&lt;i&gt;Aster yomena&lt;/i&gt; Alleviates Chronic Unpredictable Mild Stress (CUMS)-Induced Depressive Cognitive Dysfunction by Regulating the HPA Axis and TLR4/NF-κB Pathway.,2026,10.4014/jmb.2510.10048,https://pubmed.ncbi.nlm.nih.gov/41668506/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,42756908,Persistent Müllerian structures in an infant with complete androgen insensitivity syndrome.,2026,10.1210/jcemcr/luag242,https://pubmed.ncbi.nlm.nih.gov/42756908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,42707067,"Incidental discovery of neglected 11β-hydroxylase deficiency causing 46,XX disorder of sex development in a 35-year-old adult: A radiologically driven diagnosis.",2026,10.1016/j.radcr.2026.07.094,https://pubmed.ncbi.nlm.nih.gov/42707067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,41689273,"Glucocorticoid trajectories in preterm infants-born too soon, wired differently.",2026,10.1210/clinem/dgag048,https://pubmed.ncbi.nlm.nih.gov/41689273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,42475299,An optimized three-laser 27-color spectral flow cytometry panel for multi-organ profiling in mice.,2026,10.1371/journal.pone.0347810,https://pubmed.ncbi.nlm.nih.gov/42475299/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,42861445,Rare Mendelian CYP disorders: from metabolic pathways to biomarker-guided diagnosis.,2026,10.1080/03602532.2026.2743901,https://pubmed.ncbi.nlm.nih.gov/42861445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,41196557,Enhanced Catalytic Performance of P450 Monooxygenase CYP11B1 by Constructing Fusion Protein with Preferred Reductase Domain and Linker.,2026,10.1007/s12010-025-05446-3,https://pubmed.ncbi.nlm.nih.gov/41196557/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,41886894,Environmental pollutants and autism spectrum disorder: Effects of plasticizers on core phenotypes and molecular targets.,2026,10.1016/j.neurot.2026.e00870,https://pubmed.ncbi.nlm.nih.gov/41886894/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,42175782,CYP gene variants show preliminary evidence of association with patient-reported outcomes in active-duty service members with chronic pain.,2026,10.1177/17448069261454823,https://pubmed.ncbi.nlm.nih.gov/42175782/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,42847230,"Aldosterone synthase inhibitors: biological rationale, mechanism of action, and results of clinical trials.",2026,10.1093/ajh/hpag087,https://pubmed.ncbi.nlm.nih.gov/42847230/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,42402373,Evidence for de novo synthesis of corticosteroids in the human ovary.,2026,10.1093/humrep/deag107,https://pubmed.ncbi.nlm.nih.gov/42402373/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,42837060,Baxdrostat in Resistant and Uncontrolled Hypertension: A Systematic Review and Meta-Analysis.,2026,10.1007/s10557-026-07973-5,https://pubmed.ncbi.nlm.nih.gov/42837060/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,41488240,Endocrine disrupting chemicals and the adrenal gland.,2025,10.55730/1300-0144.6121,https://pubmed.ncbi.nlm.nih.gov/41488240/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,42628007,APUC-6 Genes as a Potential Prognostic and Predictive Biomarker in the CHAARTED Prostate Cancer Trial.,2026,10.1200/po-25-01012,https://pubmed.ncbi.nlm.nih.gov/42628007/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,40280300,Toxicological profiling and diuretic potential of arbutin via aldosterone synthase gene inhibition.,2025,10.1016/j.lfs.2025.123661,https://pubmed.ncbi.nlm.nih.gov/40280300/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,40576990,Machine Learning and Large Language Models for Modeling Complex Toxicity Pathways and Predicting Steroidogenesis.,2025,10.1021/acs.est.5c04054,https://pubmed.ncbi.nlm.nih.gov/40576990/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,40618316,Development of a CYP11B2 imaging tracer for primary aldosteronism: basic evaluation of iodine- and fluorine-incorporated pyridinyldihydroquinolinone derivatives.,2025,10.1186/s41181-025-00361-8,https://pubmed.ncbi.nlm.nih.gov/40618316/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,41436034,Pharmacodynamics of vicadrostat for aldosterone synthase inhibition in patients with CKD.,2026,10.1093/ejendo/lvaf265,https://pubmed.ncbi.nlm.nih.gov/41436034/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,41491887,Aldosterone synthase inhibitors across the translational spectrum: Mechanistic foundations and emerging clinical applications.,2026,10.1111/joim.70061,https://pubmed.ncbi.nlm.nih.gov/41491887/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,39152532,"First-in-human study evaluating safety, pharmacokinetics, and pharmacodynamics of lorundrostat, a novel and highly selective aldosterone synthase inhibitor.",2024,10.1111/cts.70000,https://pubmed.ncbi.nlm.nih.gov/39152532/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,38820853,Emerging trends in small molecule inhibitors targeting aldosterone synthase: A new paradigm in cardiovascular disease treatment.,2024,10.1016/j.ejmech.2024.116521,https://pubmed.ncbi.nlm.nih.gov/38820853/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,38358268,Emerging Therapies for Treatment-Resistant Hypertension: A Review of Lorundrostat and Related Selective Aldosterone Synthase Inhibitors.,2026,10.1097/crd.0000000000000665,https://pubmed.ncbi.nlm.nih.gov/38358268/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,41373593,Chronic Stress Segregates Mice into Distinct Behavioral Phenotypes Based on Glucocorticoid Sensitivity.,2025,10.3390/ijms262311436,https://pubmed.ncbi.nlm.nih.gov/41373593/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B1,ENSG00000160882,Unsafe,20200334,Adrenocortical zonation in humans under normal and pathological conditions.,2010,10.1210/jc.2009-2010,https://pubmed.ncbi.nlm.nih.gov/20200334/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42089263,Aldosterone synthase expression vs cross-sectional imaging in lateralized primary aldosteronism.,2026,10.1210/clinem/dgag194,https://pubmed.ncbi.nlm.nih.gov/42089263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42636949,Dkk3-Cyp11b2/aldosterone signaling couples ion-homeostatic failure to mitochondrial apoptosis in cochlear aging.,2026,10.1016/j.cellsig.2026.112845,https://pubmed.ncbi.nlm.nih.gov/42636949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42772699,Clinical utilization of CYP17A1 and CYP11B2 in evaluating cortisol- and aldosterone-producing adrenal nodules.,2026,10.1016/j.humpath.2026.106272,https://pubmed.ncbi.nlm.nih.gov/42772699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42158162,Histopathological evidence of osilodrostat-induced regression of a cortisol-producing adrenocortical adenoma.,2026,10.1210/jcemcr/luag093,https://pubmed.ncbi.nlm.nih.gov/42158162/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42777615,Identification of a novel small-molecule compound that suppresses depolarization-induced CYP11B2 expression and aldosterone production in KCNJ5 mutant adrenocortical cells.,2026,10.1016/j.bbrc.2026.154584,https://pubmed.ncbi.nlm.nih.gov/42777615/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42307048,Baxdrostat versus osilodrostat: steroid biosynthesis in human adrenocortical cells.,2026,10.1530/ec-25-0807,https://pubmed.ncbi.nlm.nih.gov/42307048/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42795360,Aldosterone Synthase Inhibitors: Emerging Therapeutic Strategies in Resistant Hypertension.,2026,10.3390/life16091495,https://pubmed.ncbi.nlm.nih.gov/42795360/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42196271,"The Expression of Placental 17β-Hydroxysteroid Dehydrogenase Genes Is Associated with the Elevation of Active Androgens and Estrogens in Pregnant Women, but Does Not Affect 11-Oxygenated C19 Steroids.",2026,10.3390/ijms27104290,https://pubmed.ncbi.nlm.nih.gov/42196271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,41988370,Baxdrostat: A First-in-Class Aldosterone Synthase Inhibitor for Resistant Hypertension.,2026,10.1021/acsptsci.6c00102,https://pubmed.ncbi.nlm.nih.gov/41988370/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42830519,"Aldosterone-producing adrenocortical carcinoma presenting with severe, rapidly progressive hypokalemia: a case report and literature review.",2026,10.1507/endocrj.ej26-0173,https://pubmed.ncbi.nlm.nih.gov/42830519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,41759495,ERRATUM: Intratumoural aldosterone and CYP11B2 expression levels among different genotypes of aldosterone producing tumours.,2026,10.1530/ec-25-0070e,https://pubmed.ncbi.nlm.nih.gov/41759495/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,41857472,Increased Frequency and Distinct Genotypic Patterns of Somatic Aldosterone-Driver Mutations in Aldosterone-Producing Micronodules from Primary Aldosteronism Patients.,2026,10.1007/s12022-026-09912-4,https://pubmed.ncbi.nlm.nih.gov/41857472/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,41360104,"Adrenal Cortical Steroidogenic Enzyme Expression is Associated with Hypertension, Obesity and Corticosteroid Use: A Tissue Microarray Study of Human Adrenal Tissue.",2025,10.1055/a-2738-2453,https://pubmed.ncbi.nlm.nih.gov/41360104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,40531063,Intratumoural aldosterone and CYP11B2 expression levels among different genotypes of aldosterone producing tumours.,2025,10.1530/ec-25-0070,https://pubmed.ncbi.nlm.nih.gov/40531063/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42505368,Changes in the Adrenal Cortex Induced by Liraglutide Treatment and Exercise in a Rat Model of Menopausal Transition.,2026,10.3390/cells15141258,https://pubmed.ncbi.nlm.nih.gov/42505368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42290661,CXCR4 reduces aldosterone synthesis via regulating CYP11B2 expression.,2026,10.1016/j.gendis.2025.101956,https://pubmed.ncbi.nlm.nih.gov/42290661/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,41889508,A novel compound heterozygous mutation in &lt;i&gt;CYP11B2&lt;/i&gt; (p.A153P and p.Q337&lt;i&gt;*&lt;/i&gt;) associated with primary hypoaldosteronism.,2026,10.3389/fmed.2026.1740124,https://pubmed.ncbi.nlm.nih.gov/41889508/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42911724,[18F]ApaScan: A 2-Pyridinylbenzimidazole PET Tracer with Highly Selective Binding to Human Aldosterone-Producing Adenoma Tissue.,2026,10.1021/acs.jmedchem.6c01084,https://pubmed.ncbi.nlm.nih.gov/42911724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,41691226,An interpretable machine learning model for preoperative prediction of aldosterone secretion and CYP11B2 status of adrenal gland.,2026,10.1186/s12880-026-02226-1,https://pubmed.ncbi.nlm.nih.gov/41691226/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,40472250,First-in-Human Evaluation of [ 18 F]AldoView: A Highly Selective PET Tracer for Aldosterone Synthase Imaging in Primary Aldosteronism.,2025,10.1097/rlu.0000000000006014,https://pubmed.ncbi.nlm.nih.gov/40472250/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42066037,Pubertal Exposure to Lambda-Cyhalothrin Disrupts Adrenal Steroidogenesis via Downregulation of AGTR1A/CYP11B2 and Apoptosis Induction.,2026,10.1021/acs.chemrestox.5c00405,https://pubmed.ncbi.nlm.nih.gov/42066037/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42847230,"Aldosterone synthase inhibitors: biological rationale, mechanism of action, and results of clinical trials.",2026,10.1093/ajh/hpag087,https://pubmed.ncbi.nlm.nih.gov/42847230/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42535833,Efficacy and Safety of Selective Aldosterone Synthase Inhibitors in Uncontrolled Hypertension: A Systematic Review and Dose-Specific Network Meta-Analysis of Randomized Controlled Trials.,2026,10.1097/crd.0000000000001419,https://pubmed.ncbi.nlm.nih.gov/42535833/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42334050,Efficacy and Safety of Baxdrostat for Hypertension: A Systematic Review and Meta-Analysis of Three Phase 2/3 Randomized Controlled Trials.,2026,10.1002/clc.70391,https://pubmed.ncbi.nlm.nih.gov/42334050/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42847224,From bench to formulary: a pharmacological appraisal of aldosterone synthase inhibitors for uncontrolled and resistant hypertension.,2026,10.1093/ajh/hpag077,https://pubmed.ncbi.nlm.nih.gov/42847224/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,39170743,Evaluating the role of aldosterone synthesis on adrenal cell fate.,2024,10.3389/fendo.2024.1423027,https://pubmed.ncbi.nlm.nih.gov/39170743/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42467440,"Baxdrostat and selective aldosterone synthase inhibition in hard-to-control hypertension: mechanism, evidence, safety, and future clinical positioning.",2026,10.1080/14656566.2026.2706729,https://pubmed.ncbi.nlm.nih.gov/42467440/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,38820853,Emerging trends in small molecule inhibitors targeting aldosterone synthase: A new paradigm in cardiovascular disease treatment.,2024,10.1016/j.ejmech.2024.116521,https://pubmed.ncbi.nlm.nih.gov/38820853/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,40052842,"Evaluation of Aldosterone Suppression by Cinnarizine, a Putative Cav1.3 Inhibitor.",2025,10.1210/clinem/dgaf081,https://pubmed.ncbi.nlm.nih.gov/40052842/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,41154669,Baxdrostat: A Next-Generation Aldosterone Synthase Inhibitor Offering New Hope in Resistant Hypertension.,2025,10.3390/biom15101439,https://pubmed.ncbi.nlm.nih.gov/41154669/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,41811628,Baxdrostat for the treatment of primary aldosteronism: current evidence.,2026,10.1007/s12020-026-04570-2,https://pubmed.ncbi.nlm.nih.gov/41811628/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42837060,Baxdrostat in Resistant and Uncontrolled Hypertension: A Systematic Review and Meta-Analysis.,2026,10.1007/s10557-026-07973-5,https://pubmed.ncbi.nlm.nih.gov/42837060/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,40618316,Development of a CYP11B2 imaging tracer for primary aldosteronism: basic evaluation of iodine- and fluorine-incorporated pyridinyldihydroquinolinone derivatives.,2025,10.1186/s41181-025-00361-8,https://pubmed.ncbi.nlm.nih.gov/40618316/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,42650821,Mechanisms of Obesity-Related Kidney Disease: From Adipose Depot Biology to the Chymase-Aldosterone and Ghrelin-Leptin Axes.,2026,10.3390/biom16081155,https://pubmed.ncbi.nlm.nih.gov/42650821/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,39557029,Aldosterone Synthase Inhibitors for Cardiorenal Protection: Ready for Prime Time?,2024,10.1159/000542621,https://pubmed.ncbi.nlm.nih.gov/39557029/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP11B2,ENSG00000179142,Unsafe,20200334,Adrenocortical zonation in humans under normal and pathological conditions.,2010,10.1210/jc.2009-2010,https://pubmed.ncbi.nlm.nih.gov/20200334/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42280472,Obesity Triggers Dysregulation of Essential ABC Transporters in Rat Testis and Sperm.,2026,10.3390/nu18111829,https://pubmed.ncbi.nlm.nih.gov/42280472/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42593817,CYP19A1 variation in healthy children: associations with breast development and pubertal gynecomastia.,2026,10.1530/ec-26-0182,https://pubmed.ncbi.nlm.nih.gov/42593817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42043681,Pan-cancer analysis and experimental validation identify CYP19A1 as a prognostic biomarker and oncogenic driver associated with tumor immune microenvironment regulation in gastrointestinal cancers.,2026,10.1007/s12672-026-04998-y,https://pubmed.ncbi.nlm.nih.gov/42043681/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42178336,"VISFATIN: a novel modulator of placental endocrinology under physiological and pathological conditions-in vitro studies involving INSR, ERK1/2, and PKA signalling pathways.",2026,10.1038/s41598-026-52422-w,https://pubmed.ncbi.nlm.nih.gov/42178336/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42356409,Prevention of Diet-Induced Obesity by Phytoecdysteroids 20-Hydroxyecdysone and Calonysterone-Unexpected Modulation of Androgen Balance in Normal and Obese Rats.,2026,10.3390/nu18122023,https://pubmed.ncbi.nlm.nih.gov/42356409/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42668842,"Prenatal environmental determinants of aromatase brain-promoter methylation in cord blood: chemical, airborne, pharmacological, and nutritional factors.",2026,10.1093/eep/dvag027,https://pubmed.ncbi.nlm.nih.gov/42668842/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42624786,Seed pairing between a small regulatory RNA and target mRNA determines cleavage by an RNase E with a minimal C-terminal scaffold.,2026,10.1261/rna.080914.125,https://pubmed.ncbi.nlm.nih.gov/42624786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,41745835,Caffeine Exposure Modulates Trophoblast Differentiation and Estradiol Synthesis.,2026,10.3390/toxics14020161,https://pubmed.ncbi.nlm.nih.gov/41745835/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42897682,"Incidence and aetiology of diarrhoeal disease among children under five years in the post-rotavirus vaccine introduction era in Manhiça District, Mozambique.",2026,10.1186/s41182-026-01095-2,https://pubmed.ncbi.nlm.nih.gov/42897682/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42100217,Integrative analysis of the hypothalamic-pituitary-testicular axis reveals molecular mechanisms underlying sperm motility differences in Landes ganders.,2026,10.3389/fvets.2026.1809258,https://pubmed.ncbi.nlm.nih.gov/42100217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,41836328,Effects of Methandienone on the ovaries of rabbits in relation to the aromatase gene (CYP19A1) and oxidative markers and the possible protective role of selenium.,2026,10.12688/f1000research.174480.2,https://pubmed.ncbi.nlm.nih.gov/41836328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42560550,"Escin ameliorates letrozole-induced polycystic ovarian syndrome by modulating inflammatory, oxidative stress, and steroidogenic pathways in Wistar rats: integration of network pharmacology and molecular docking.",2026,10.1007/s00210-026-05791-y,https://pubmed.ncbi.nlm.nih.gov/42560550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42152082,Identification of the CYP19A1-GPER1 axis as a critical oncogenic driver in hepatocellular carcinoma via AKT activation.,2026,10.1186/s12967-026-08246-3,https://pubmed.ncbi.nlm.nih.gov/42152082/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42737662,Molecular Mechanisms of Endocrine-Disrupting Chemicals and Emerging-Pollutant Toxicity in Human Reproduction: From Xenobiotic Exposure to Fertility Impairment and Reproductive Carcinogenesis.,2026,10.3390/ijms27177766,https://pubmed.ncbi.nlm.nih.gov/42737662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42465163,Spectrum of Cytogenetic and Molecular Abnormalities in Disorders of Sex Development: A Retrospective Observational Study From Western India.,2026,10.7759/cureus.110941,https://pubmed.ncbi.nlm.nih.gov/42465163/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,41565585,Low Testosterone in Men With Type 2 Diabetes: The Role of Estrogen Excess and Aromatase Activity.,2026,10.1111/cen.70098,https://pubmed.ncbi.nlm.nih.gov/41565585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42908724,Erratum: CYP19A1 is downregulated by BRD4 and suppresses castration-resistant prostate cancer cell invasion and proliferation by decreasing AR expression.,2026,10.62347/vgmj2050,https://pubmed.ncbi.nlm.nih.gov/42908724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42372500,"The effect of platelet-rich plasma extracellular vesicles (PRP-EVs) on the expression of BECN1, CYP19a1, and BMP6 as critical genes related to autophagy and steroidogenesis in ovarian granulosa cells of polycystic ovarian syndrome (PCOS) mouse model.",2026,10.1016/j.tice.2026.103717,https://pubmed.ncbi.nlm.nih.gov/42372500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,41715211,Sex chromosome-dependent epigenetic regulation underlies sex-specific H4 acetylation at the aromatase promoter in the developing mouse amygdala.,2026,10.1186/s13293-026-00854-4,https://pubmed.ncbi.nlm.nih.gov/41715211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,41629966,Sex-specific gonadal transcriptome during early development of Siberian sturgeon.,2026,10.1186/s13293-025-00810-8,https://pubmed.ncbi.nlm.nih.gov/41629966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42853327,Mechanistic assessment of hepato-reproductive toxicity of Mentha pulegium L. essential oil in rats.,2026,10.1007/s11033-026-12842-3,https://pubmed.ncbi.nlm.nih.gov/42853327/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,41494372,Computational screening reveals class-wide CYP19A1 binding potential across per- and polyfluoroalkyl substances.,2026,10.1016/j.ecoenv.2026.119675,https://pubmed.ncbi.nlm.nih.gov/41494372/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,41219799,Cyclophilins as key players in protozoan parasite infections.,2025,10.1186/s13071-025-07098-y,https://pubmed.ncbi.nlm.nih.gov/41219799/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42003697,"Network toxicology and molecular docking elucidation of oligoasthenospermia induced by bisphenol analogues: a comparative study of BPA, BPS, BPF, and BPAF.",2026,10.1080/1062936x.2026.2659333,https://pubmed.ncbi.nlm.nih.gov/42003697/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42304516,Analysis of in vitro profiling data of cosmetic ingredients within the Tox21 10K compound library for bioactivity and potential toxicity.,2026,10.1186/s40360-026-01165-5,https://pubmed.ncbi.nlm.nih.gov/42304516/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42277171,"A tri-target in silico analysis of Testolift: a nutraceutical formulation targeting aromatase, myostatin, and prolyl hydroxylase-2 in testosterone regulation and muscle performance.",2026,10.1038/s41598-026-57541-y,https://pubmed.ncbi.nlm.nih.gov/42277171/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42564789,Multifunctional LA and PTMC coating for biliary stents to combat cholangiocarcinoma proliferation in obstruction.,2026,10.1016/j.isci.2026.116093,https://pubmed.ncbi.nlm.nih.gov/42564789/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42903404,Bisphenol M Impairs Ovarian Function through Disrupting Estrogen Synthesis in Female Mice: A Comparative Study with Bisphenol A.,2026,10.1021/envhealth.6c00098,https://pubmed.ncbi.nlm.nih.gov/42903404/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,41763411,"A novel thiadiazole-steroid hybrid as a CYP19A1 inhibitor: Synthesis, molecular interaction analysis and assessment of steroid receptor signaling.",2026,10.1016/j.jsbmb.2026.106974,https://pubmed.ncbi.nlm.nih.gov/41763411/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,41932378,"Toxic effects of bisphenol M, a bisphenol A substitute, on early developmental stages of marine medaka (Oryzias melastigma).",2026,10.1016/j.envpol.2026.128052,https://pubmed.ncbi.nlm.nih.gov/41932378/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,39951078,Effect of the Ten-valent Pneumococcal Conjugate Vaccine on Invasive Pneumococcal Disease and Pneumonia in Infants Younger Than Ten Weeks of Age in Southern Mozambique: A Population-based Prospective Surveillance Study.,2025,10.1097/inf.0000000000004638,https://pubmed.ncbi.nlm.nih.gov/39951078/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42708871,"Peripubertal Exposure to Silver Nanoparticles (AgNPs) Triggers Follicle Activation, Probably Leading to ""Burnout"" by Stimulating the PI3K/AKT/mTOR/AMPK Signaling Pathway.",2026,,https://pubmed.ncbi.nlm.nih.gov/42708871/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,42595065,Jinfeng Pills alleviate letrozole-induced PCOS by correcting CYP17A1/CYP19A1 steroidogenic imbalance and PI3K/Akt/mTOR-related signaling.,2027,10.1016/j.jep.2026.122268,https://pubmed.ncbi.nlm.nih.gov/42595065/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,41050076,CYP19A1 Silencing Inhibits Cell Proliferation and Endoplasmic Reticulum Stress in Stomach Adenocarcinoma.,2025,10.32604/or.2025.062250,https://pubmed.ncbi.nlm.nih.gov/41050076/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,8117272,Novel exon 1 of the aromatase gene specific for aromatase transcripts in human brain.,1994,10.1006/bbrc.1994.1163,https://pubmed.ncbi.nlm.nih.gov/8117272/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,7690033,Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue.,1993,10.1016/s0021-9258(19)36538-x,https://pubmed.ncbi.nlm.nih.gov/7690033/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,2040633,Tissue-specific expression of human P-450AROM. The promoter responsible for expression in adipose tissue is different from that utilized in placenta.,1991,10.1016/s0021-9258(18)99159-3,https://pubmed.ncbi.nlm.nih.gov/2040633/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP19A1,ENSG00000137869,Unsafe,3018730,Isolation and characterization of a complementary DNA specific for human aromatase-system cytochrome P-450 mRNA.,1986,10.1073/pnas.83.17.6387,https://pubmed.ncbi.nlm.nih.gov/3018730/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42387303,"Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure.",2026,10.1002/cpt.70376,https://pubmed.ncbi.nlm.nih.gov/42387303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42008658,Evaluation of the cytochrome P450-mediated drug interaction profile of olorofim.,2026,10.1128/aac.01745-25,https://pubmed.ncbi.nlm.nih.gov/42008658/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42555833,Investigation of Thymoquinone as an Inhibitor of CYP2C8/EET Axis.,2026,10.1002/cbic.202600003,https://pubmed.ncbi.nlm.nih.gov/42555833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,41563903,Managing Drug-Drug Interactions Involving the Non-Prescription Opioid Loperamide Through Physiologically Based Pharmacokinetic Modeling.,2026,10.1002/psp4.70148,https://pubmed.ncbi.nlm.nih.gov/41563903/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42815442,Repaglinide metabolism by human hepatocytes reveals CYP2C8 dominance and misassignment of CYP3A4 by liver subcellular fractions and recombinant enzymes.,2026,10.1016/j.dmd.2026.100400,https://pubmed.ncbi.nlm.nih.gov/42815442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42198321,Expanding the Gene Expression Profiling of Drug Transporters and Drug-Metabolizing Enzymes to Include the Upper Female Reproductive Tract.,2026,10.3390/pharmaceutics18050629,https://pubmed.ncbi.nlm.nih.gov/42198321/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42449129,Contribution of cytochrome P450-mediated metabolism to clavulanic acid-induced cytotoxicity in TK6-derived cytochrome P450-overexpressing cell lines.,2026,10.1038/s41598-026-59728-9,https://pubmed.ncbi.nlm.nih.gov/42449129/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42843233,Tyrosine kinase inhibitors suppress cytochrome P450 2C8 and 2J2 functions and their expression in renal cell carcinoma.,2026,10.1016/j.dmpk.2026.101542,https://pubmed.ncbi.nlm.nih.gov/42843233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,41070226,Identifying metabolism-related genes in liver cancer through weighted gene co-expression network analysis and machine learning.,2025,10.3389/fgene.2025.1654459,https://pubmed.ncbi.nlm.nih.gov/41070226/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42597673,Physiologically based pharmacokinetic model of two ALK inhibitors to inform drug and dosing regimens for brain metastasis patients.,2026,10.3389/fphar.2026.1901617,https://pubmed.ncbi.nlm.nih.gov/42597673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,41014112,"Evaluation of the Pharmacokinetics, Disposition, and Metabolism of Miricorilant, a Novel Glucocorticoid Receptor Modulator for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis in Nonclinical and Clinical Studies.",2026,10.1002/jcph.70113,https://pubmed.ncbi.nlm.nih.gov/41014112/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,41857360,The involvement of miRNAs in CYP450 enzymes and UDP-glucuronosyltransferases regulation in the human liver.,2026,10.1038/s41598-026-45113-z,https://pubmed.ncbi.nlm.nih.gov/41857360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42016385,"Preclinical Pharmacokinetics, ADME, and Drug-Drug Interaction Evaluation of S024, a Novel p38/MK2 Inhibitor for Rheumatoid Arthritis.",2026,10.2147/dddt.s591017,https://pubmed.ncbi.nlm.nih.gov/42016385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,40980418,CYP2C8-Mediated Drug-Drug Interactions and the Factors Influencing the Interaction Magnitude.,2025,10.2147/dddt.s541536,https://pubmed.ncbi.nlm.nih.gov/40980418/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,41590876,Evaluation of CYP2C8 and CYP2C9 Polymorphisms in Neonates with Patent Ductus Arteriosus Treated with Ibuprofen or Indomethacin: A Retrospective Cohort Study.,2026,10.3390/jcdd13010049,https://pubmed.ncbi.nlm.nih.gov/41590876/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,41576443,"Effect of selenium yeast supplementation on drug metabolism genes, oxidative stress, and apoptosis in chicken liver after diquat induction: A proteomic perspective.",2026,10.1016/j.psj.2026.106469,https://pubmed.ncbi.nlm.nih.gov/41576443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42265836,"Pharmacokinetics, mass balance and metabolic profiling of resmetirom in healthy subjects and nonclinical metabolism and disposition.",2026,10.1080/00498254.2026.2687126,https://pubmed.ncbi.nlm.nih.gov/42265836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42581437,Pharmacokinetic Drug-Drug Interactions of Imlunestrant in Healthy Female Participants of Nonchildbearing Potential.,2026,10.1111/cts.70680,https://pubmed.ncbi.nlm.nih.gov/42581437/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,41106572,Transcription factors of the Nuclear Factor I (NFI) family control hepatocyte differentiation and cytochrome P450 activity in human liver.,2025,10.1016/j.phrs.2025.107998,https://pubmed.ncbi.nlm.nih.gov/41106572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,41847173,Prediction of Biomarkers for Hepatocellular Carcinoma Based on Proteomics and Phosphoproteomics.,2026,10.2147/ijgm.s573963,https://pubmed.ncbi.nlm.nih.gov/41847173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42763370,Association of genetic polymorphisms with response to preoperative NSAIDs in endodontic postoperative pain: a randomized double-blind placebo-controlled clinical trial.,2026,10.1007/s10266-026-01536-8,https://pubmed.ncbi.nlm.nih.gov/42763370/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42870606,Ocular Distribution and Metabolite Profiling of Vorolanib in Rats and Its &lt;i&gt;In Vitro&lt;/i&gt; Metabolism Using Human Recombinant Enzymes.,2026,10.1177/10807683261496831,https://pubmed.ncbi.nlm.nih.gov/42870606/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42047943,Personalizing Liposomal Paclitaxel in Platinum-Based Combination Therapy for Gynecologic Cancers: Defining a Therapeutic Window Based on Tc&lt;sub&gt;&gt;0.05&lt;/sub&gt; and CYP2C8 Metabolic Capacity.,2026,10.1007/s13318-026-01001-5,https://pubmed.ncbi.nlm.nih.gov/42047943/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,41566036,"Drug-drug interactions with pioglitazone, losartan, and midazolam and anti-tumor efficacy and safety study of TAS-115 in patients with solid tumors.",2026,10.1007/s00280-025-04855-9,https://pubmed.ncbi.nlm.nih.gov/41566036/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,41300713,Towards Personalized Chemotherapy in Gastrointestinal Cancers: Prospective Analysis of Pharmacogenetic Variants in a Russian Cohort.,2025,10.3390/genes16111261,https://pubmed.ncbi.nlm.nih.gov/41300713/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,40406962,An in-depth review of PPARγ modulators as anti-diabetes therapeutics.,2025,10.1080/03602532.2025.2508152,https://pubmed.ncbi.nlm.nih.gov/40406962/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42159749,Differential induction of hepatic CYP enzymes by tobacco products and e-cigarettes: recommendation to rethink smoking status in clinical pharmacology.,2026,10.1007/s00204-026-04428-6,https://pubmed.ncbi.nlm.nih.gov/42159749/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,41998749,The DHCQ/HCQ metabolic ratio and CYP2C8 Genotype are associated with lipid profile improvement in systemic lupus erythematosus patients treated with hydroxychloroquine.,2026,10.1186/s13075-026-03813-x,https://pubmed.ncbi.nlm.nih.gov/41998749/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42904354,Pharmacogenetic Determinants of Chemotherapy Response in Breast Cancer: A Comprehensive Review of Chemotherapeutic Agents.,2026,10.4103/aam.aam_589_26,https://pubmed.ncbi.nlm.nih.gov/42904354/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42078931,"Safety, tolerability, pharmacokinetics, and pharmacodynamics of zapnometinib: results from a phase I clinical study.",2026,10.3389/fphar.2026.1743230,https://pubmed.ncbi.nlm.nih.gov/42078931/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,41455147,Interindividual variability in imatinib metabolism in human liver microsomes and primary human hepatocytes: Impact of CYP2C8 and CYP3A phenotypes.,2025,10.1016/j.dmd.2025.100196,https://pubmed.ncbi.nlm.nih.gov/41455147/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,40591133,"Association of CYP3A5, ABCB1, and CYP2C8 Polymorphisms with Renal Function in Kidney Transplant Recipients Receiving Tacrolimus.",2025,10.1007/s13318-025-00955-2,https://pubmed.ncbi.nlm.nih.gov/40591133/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42693680,"&lt;i&gt;In vitro&lt;/i&gt; assessments for pharmacokinetic drug-drug interaction potential of vornorexant, a novel dual orexin 1/2 receptor antagonist.",2026,10.1080/00498254.2026.2720767,https://pubmed.ncbi.nlm.nih.gov/42693680/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYP2C8,ENSG00000138115,Unsafe,42123691,Impact of Pharmacogenetic Markers on the Efficacy of Neoadjuvant FLOT Chemotherapy in Patients with Gastric and Gastroesophageal Junction Adenocarcinoma.,2026,10.3390/ijms27094114,https://pubmed.ncbi.nlm.nih.gov/42123691/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,41351323,A TIR-NLR gene from Arabidopsis Pla-1 confers resistance to geminivirus infection.,2025,10.1111/tpj.70628,https://pubmed.ncbi.nlm.nih.gov/41351323/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,41154668,Transcriptional Profiling Defines Unique Subtypes of Transit Amplifying Neural Progenitors Within the Neonatal Mouse Subventricular Zone.,2025,10.3390/biom15101438,https://pubmed.ncbi.nlm.nih.gov/41154668/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,39798396,Differentially expressed messenger RNA isoforms in beef cattle skeletal muscle with different fatty acid profiles.,2025,10.1016/j.meatsci.2025.109751,https://pubmed.ncbi.nlm.nih.gov/39798396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,40710378,Optimizing PH Domain-Based Biosensors for Improved Plasma Membrane PIP&lt;sub&gt;3&lt;/sub&gt; Measurements in Mammalian Cells.,2025,10.3390/cells14141125,https://pubmed.ncbi.nlm.nih.gov/40710378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,40834973,Heat stress-induced genomic instability in neural stem cells and its association with neuronal developmental deficits.,2025,10.1016/j.brainresbull.2025.111517,https://pubmed.ncbi.nlm.nih.gov/40834973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,33550894,LncRNA Neat1 expedites the progression of liver fibrosis in mice through targeting miR-148a-3p and miR-22-3p to upregulate Cyth3.,2021,10.1080/15384101.2021.1875665,https://pubmed.ncbi.nlm.nih.gov/33550894/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,39316909,Potential prebiotic properties and proliferation mechanism of fermented milk-derived polypeptides.,2025,10.1016/j.foodchem.2024.141335,https://pubmed.ncbi.nlm.nih.gov/39316909/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,39806399,Longitudinal DNA methylation profiles in saliva of offspring from mothers with gestational diabetes: associations with early childhood growth patterns.,2025,10.1186/s12933-024-02568-6,https://pubmed.ncbi.nlm.nih.gov/39806399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,33540491,LPAR5 promotes thyroid carcinoma cell proliferation and migration by activating class IA PI3K catalytic subunit p110β.,2021,10.1111/cas.14837,https://pubmed.ncbi.nlm.nih.gov/33540491/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,34413360,A machine learning approach to identify predictive molecular markers for cisplatin chemosensitivity following surgical resection in ovarian cancer.,2021,10.1038/s41598-021-96072-6,https://pubmed.ncbi.nlm.nih.gov/34413360/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,38455128,Identification of immune cell-related prognostic genes characterized by a distinct microenvironment in hepatocellular carcinoma.,2024,10.5306/wjco.v15.i2.243,https://pubmed.ncbi.nlm.nih.gov/38455128/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,37056792,Canaloplasty and Trabeculotomy with the OMNI System in Patients with Open-Angle Glaucoma: Two-Year Results from the ROMEO Study.,2023,10.2147/opth.s407918,https://pubmed.ncbi.nlm.nih.gov/37056792/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,33026967,Coordination of Grp1 recruitment mechanisms by its phosphorylation.,2020,10.1091/mbc.e20-03-0173,https://pubmed.ncbi.nlm.nih.gov/33026967/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,31762060,Microscopic Characterization of GRP1 PH Domain Interaction with Anionic Membranes.,2020,10.1002/jcc.26109,https://pubmed.ncbi.nlm.nih.gov/31762060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,36964902,Genetic variation in the glycine-rich protein gene BnGRP1 contributes to low phosphorus tolerance in Brassica napus.,2023,10.1093/jxb/erad114,https://pubmed.ncbi.nlm.nih.gov/36964902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,30837656,Cytohesin-3 is required for full insulin receptor signaling and controls body weight via lipid excretion.,2019,10.1038/s41598-019-40231-3,https://pubmed.ncbi.nlm.nih.gov/30837656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,35413358,Neuroprotective role of Bacopa monnieri extract in modulating depression in an experimental rat model.,2022,10.1016/j.jad.2022.04.021,https://pubmed.ncbi.nlm.nih.gov/35413358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,34459503,Insight into the cellular and physiological regulatory modulations of Class-I TCP9 to enhance drought and salinity stress tolerance in cowpea.,2022,10.1111/ppl.13542,https://pubmed.ncbi.nlm.nih.gov/34459503/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,30912296,Regular consumption of green tea improves pulse pressure and induces regression of left ventricular hypertrophy in hypertensive patients.,2019,10.14814/phy2.14030,https://pubmed.ncbi.nlm.nih.gov/30912296/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,33649051,Host Genome-Wide Association Study of Infant Susceptibility to Shigella-Associated Diarrhea.,2021,10.1128/iai.00012-21,https://pubmed.ncbi.nlm.nih.gov/33649051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,42287525,"Retail cattle meat as a reservoir of multidrug-resistant Salmonella harboring β-lactamase genes in Sylhet, Bangladesh.",2026,10.1007/s11259-026-11344-8,https://pubmed.ncbi.nlm.nih.gov/42287525/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,39210729,Effect of ear cleaning on treatment outcome for canine otitis externa.,2024,10.1111/vde.13292,https://pubmed.ncbi.nlm.nih.gov/39210729/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,35958598,Comprehensive &lt;i&gt;FGFR3&lt;/i&gt; alteration-related transcriptomic characterization is involved in immune infiltration and correlated with prognosis and immunotherapy response of bladder cancer.,2022,10.3389/fimmu.2022.931906,https://pubmed.ncbi.nlm.nih.gov/35958598/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,26618395,Can textured insoles improve ankle proprioception and performance in dancers?,2016,10.1080/02640414.2015.1117120,https://pubmed.ncbi.nlm.nih.gov/26618395/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,31601460,Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes.,2019,10.1016/j.str.2019.09.007,https://pubmed.ncbi.nlm.nih.gov/31601460/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,22640474,Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome.,2012,10.1186/1750-1326-7-24,https://pubmed.ncbi.nlm.nih.gov/22640474/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,20527794,Specificity and membrane partitioning of Grsp1 signaling complexes with Grp1 family Arf exchange factors.,2010,10.1021/bi1000454,https://pubmed.ncbi.nlm.nih.gov/20527794/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,29848659,Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6.,2018,10.1242/jcs.213314,https://pubmed.ncbi.nlm.nih.gov/29848659/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,22666423,ADP-ribosylation factor 6 expression and activation are reduced in myometrium in complicated pregnancies.,2012,10.1371/journal.pone.0037954,https://pubmed.ncbi.nlm.nih.gov/22666423/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,22077246,Assessment of the severity of organophosphate (fenitrothion) poisoning based on its serum concentration and clinical parameters.,2011,10.3109/15563650.2011.617306,https://pubmed.ncbi.nlm.nih.gov/22077246/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,22179837,Inhibition of cell migration by PITENINs: the role of ARF6.,2012,10.1038/onc.2011.593,https://pubmed.ncbi.nlm.nih.gov/22179837/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,10605025,Anergic T lymphocytes selectively express an integrin regulatory protein of the cytohesin family.,2000,10.4049/jimmunol.164.1.308,https://pubmed.ncbi.nlm.nih.gov/10605025/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,17325368,Effect of the phosphatidylinositol 3-kinase/Akt pathway on influenza A virus propagation.,2007,10.1099/vir.0.82483-0,https://pubmed.ncbi.nlm.nih.gov/17325368/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
CYTH3,ENSG00000008256,Unsafe,14970203,RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis.,2004,10.1074/jbc.m314273200,https://pubmed.ncbi.nlm.nih.gov/14970203/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,42773161,Biallelic DAW1 variants reveal a tissue-specific role in heterotaxy without primary ciliary dyskinesia.,2026,10.1038/s41431-026-02228-1,https://pubmed.ncbi.nlm.nih.gov/42773161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,42512880,Differential Gene Expression in Synovium Between Male and Female Knee Osteoarthritis.,2026,10.3390/medicina62071338,https://pubmed.ncbi.nlm.nih.gov/42512880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,35708608,Daw1 regulates the timely onset of cilia motility during development.,2022,10.1242/dev.200017,https://pubmed.ncbi.nlm.nih.gov/35708608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,39880089,Integrative in silico and biochemical analyses demonstrate direct Arl3-mediated ODA16 release from the intraflagellar transport machinery.,2025,10.1016/j.jbc.2025.108237,https://pubmed.ncbi.nlm.nih.gov/39880089/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,39231220,ARL3 GTPases facilitate ODA16 unloading from IFT in motile cilia.,2024,10.1126/sciadv.adq2950,https://pubmed.ncbi.nlm.nih.gov/39231220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,36074124,Biallelic DAW1 variants cause a motile ciliopathy characterized by laterality defects and subtle ciliary beating abnormalities.,2022,10.1016/j.gim.2022.07.019,https://pubmed.ncbi.nlm.nih.gov/36074124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,32359074,Dynein assembly factor with WD repeat domains 1 (DAW1) is required for the function of motile cilia in the planarian Schmidtea mediterranea.,2020,10.1111/dgd.12669,https://pubmed.ncbi.nlm.nih.gov/32359074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,40646788,"Genetic Parameters, Linear Associations, and Genome-Wide Association Study for Endotoxin-Induced Cortisol Response in &lt;i&gt;Holstein heifers&lt;/i&gt;.",2025,10.3390/ani15131890,https://pubmed.ncbi.nlm.nih.gov/40646788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,41297249,TPM2 as a novel inflammatory regulator in severe obstetric disorders: Integrative bioinformatics and functional validation.,2026,10.1016/j.tice.2025.103222,https://pubmed.ncbi.nlm.nih.gov/41297249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,32239748,Purification and crystal structure of human ODA16: Implications for ciliary import of outer dynein arms by the intraflagellar transport machinery.,2020,10.1002/pro.3864,https://pubmed.ncbi.nlm.nih.gov/32239748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,36533425,Cargo adapters expand the transport range of intraflagellar transport.,2022,10.1242/jcs.260408,https://pubmed.ncbi.nlm.nih.gov/36533425/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,32453791,Proteomics of intracellular freezing survival.,2020,10.1371/journal.pone.0233048,https://pubmed.ncbi.nlm.nih.gov/32453791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,20568242,Oda16/Wdr69 is essential for axonemal dynein assembly and ciliary motility during zebrafish embryogenesis.,2010,10.1002/dvdy.22355,https://pubmed.ncbi.nlm.nih.gov/20568242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,29175859,Investigating trehalose synthesis genes after cold acclimation in the Antarctic nematode Panagrolaimus sp. DAW1.,2017,10.1242/bio.023341,https://pubmed.ncbi.nlm.nih.gov/29175859/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,31653946,Genome-wide differential expression profiling of lncRNAs and mRNAs associated with early diabetic cardiomyopathy.,2019,10.1038/s41598-019-51872-9,https://pubmed.ncbi.nlm.nih.gov/31653946/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,28701346,The N-terminus of IFT46 mediates intraflagellar transport of outer arm dynein and its cargo-adaptor ODA16.,2017,10.1091/mbc.e17-03-0172,https://pubmed.ncbi.nlm.nih.gov/28701346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,30133350,In vivo analysis of outer arm dynein transport reveals cargo-specific intraflagellar transport properties.,2018,10.1091/mbc.e18-05-0291,https://pubmed.ncbi.nlm.nih.gov/30133350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,27832164,Establishing RNAi in a Non-Model Organism: The Antarctic Nematode Panagrolaimus sp. DAW1.,2016,10.1371/journal.pone.0166228,https://pubmed.ncbi.nlm.nih.gov/27832164/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,28298440,Structural basis of outer dynein arm intraflagellar transport by the transport adaptor protein ODA16 and the intraflagellar transport protein IFT46.,2017,10.1074/jbc.m117.780155,https://pubmed.ncbi.nlm.nih.gov/28298440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,33634306,A novel DNA methylation-based model that effectively predicts prognosis in hepatocellular carcinoma.,2021,10.1042/bsr20203945,https://pubmed.ncbi.nlm.nih.gov/33634306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAW1,ENSG00000123977,Unsafe,18852297,ODA16 aids axonemal outer row dynein assembly through an interaction with the intraflagellar transport machinery.,2008,10.1083/jcb.200802025,https://pubmed.ncbi.nlm.nih.gov/18852297/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ4,ENSG00000205916,Unsafe,27457284,gr/gr-DAZ2-DAZ4-CDY1b deletion is a high-risk factor for male infertility in Tunisian population.,2016,10.1016/j.gene.2016.07.050,https://pubmed.ncbi.nlm.nih.gov/27457284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ4,ENSG00000205916,Unsafe,24878370,Combined deletion of DAZ2 and DAZ4 copies of Y chromosome DAZ gene is associated with male infertility in Tunisian men.,2014,10.1016/j.gene.2014.05.061,https://pubmed.ncbi.nlm.nih.gov/24878370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ4,ENSG00000205916,Unsafe,26931020,[Association of the deleted DAZ gene copy related to gr/gr and b2/b3 deletions with spermatogenic impairment].,2016,,https://pubmed.ncbi.nlm.nih.gov/26931020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ4,ENSG00000205916,Unsafe,27723784,Discrimination of Deletion and Duplication Subtypes of the Deleted in Azoospermia Gene Family in the Context of Frequent Interloci Gene Conversion.,2016,10.1371/journal.pone.0163936,https://pubmed.ncbi.nlm.nih.gov/27723784/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ4,ENSG00000205916,Unsafe,20823911,Associations of Y-chromosome subdeletion gr/gr with the prevalence of Y-chromosome haplogroups in infertile patients.,2011,10.1038/ejhg.2010.151,https://pubmed.ncbi.nlm.nih.gov/20823911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ4,ENSG00000205916,Unsafe,14639527,A large AZFc deletion removes DAZ3/DAZ4 and nearby genes from men in Y haplogroup N.,2004,10.1086/381132,https://pubmed.ncbi.nlm.nih.gov/14639527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ4,ENSG00000205916,Unsafe,16596261,Quantitative evaluation of partial deletions of the DAZ gene cluster.,2006,10.3892/ijmm.17.5.785,https://pubmed.ncbi.nlm.nih.gov/16596261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ4,ENSG00000205916,Unsafe,16963411,[Study on DAZ gene copy deletion in severe oligozoospermia sperm donor for ICSI].,2006,10.1360/yc-006-1057,https://pubmed.ncbi.nlm.nih.gov/16963411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ4,ENSG00000205916,Unsafe,21852246,Additional genomic duplications in AZFc underlie the b2/b3 deletion-associated risk of spermatogenic impairment in Han Chinese population.,2011,10.1093/hmg/ddr369,https://pubmed.ncbi.nlm.nih.gov/21852246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ4,ENSG00000205916,Unsafe,21837945,[Sequence tagged sites of AZFc microdeletion in Chinese Han population].,2011,,https://pubmed.ncbi.nlm.nih.gov/21837945/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ4,ENSG00000205916,Unsafe,20873591,[Partial AZfc region deletions of the Y chromosome in spermatogenic dysfunction patients].,2010,,https://pubmed.ncbi.nlm.nih.gov/20873591/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ4,ENSG00000205916,Unsafe,20039973,Differential effect of specific gr/gr deletion subtypes on spermatogenesis in the Chinese Han population.,2010,10.1111/j.1365-2605.2009.01015.x,https://pubmed.ncbi.nlm.nih.gov/20039973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ4,ENSG00000205916,Unsafe,17416365,AZFc partial deletions in Chilean men with severe spermatogenic failure.,2007,10.1016/j.fertnstert.2007.01.038,https://pubmed.ncbi.nlm.nih.gov/17416365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ4,ENSG00000205916,Unsafe,15744033,Association of partial AZFc region deletions with spermatogenic impairment and male infertility.,2005,10.1136/jmg.2004.025833,https://pubmed.ncbi.nlm.nih.gov/15744033/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ4,ENSG00000205916,Unsafe,19223287,Polymorphic expression of DAZ proteins in the human testis.,2009,10.1093/humrep/dep032,https://pubmed.ncbi.nlm.nih.gov/19223287/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ4,ENSG00000205916,Unsafe,18385127,Restricted expression of the human DAZ protein in premeiotic germ cells.,2008,10.1093/humrep/den099,https://pubmed.ncbi.nlm.nih.gov/18385127/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DAZ4,ENSG00000205916,Unsafe,10936047,Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome.,2000,10.1006/geno.2000.6260,https://pubmed.ncbi.nlm.nih.gov/10936047/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,42163235,USP48 promotes tumour progression through the deubiquitination and stabilization of DBF4 in clear cell renal carcinoma.,2026,10.1186/s12935-026-04333-z,https://pubmed.ncbi.nlm.nih.gov/42163235/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,42438600,Identification of immunopeptides (pHLA) as candidate therapeutic targets in chondrosarcoma.,2026,10.1016/j.jbo.2026.100780,https://pubmed.ncbi.nlm.nih.gov/42438600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,42337302,"Exploring the multifaceted Dbf4-dependent kinase from temporal, spatial, and substrate repertoire perspectives.",2026,10.1038/s42003-026-10512-5,https://pubmed.ncbi.nlm.nih.gov/42337302/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,42902126,Transcriptome analysis and hormone metabolic profiling provide molecular insights into flowering process in petunia.,2026,10.1186/s12870-026-09062-z,https://pubmed.ncbi.nlm.nih.gov/42902126/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,39815239,Clinical significance and pro-oncogenic function of DBF4 in clear cell renal cell carcinoma.,2025,10.1186/s12894-025-01694-x,https://pubmed.ncbi.nlm.nih.gov/39815239/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,42624872,A network toxicology and machine learning approach to uncover the molecular machinery of bisphenol A-induced colorectal cancer.,2026,10.1038/s41598-026-66914-2,https://pubmed.ncbi.nlm.nih.gov/42624872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,40561849,miRTARGET: An integrated web tool for the identification of microRNA targets with potential therapeutic or prognostic value in cancer.,2025,10.1016/j.neo.2025.101202,https://pubmed.ncbi.nlm.nih.gov/40561849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,41904138,Dbf4-dependent kinase finetunes Ino80 function at chromosome replication origins.,2026,10.1038/s41467-026-70698-4,https://pubmed.ncbi.nlm.nih.gov/41904138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,38724606,The prognostic significance and potential mechanism of DBF4 zinc finger in hepatocellular carcinoma.,2024,10.1038/s41598-024-60342-w,https://pubmed.ncbi.nlm.nih.gov/38724606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,42593582,DBF4B promotes hepatocellular carcinoma progression by regulating CCNA2 and PSMD11 expression.,2026,10.1007/s11033-026-12475-6,https://pubmed.ncbi.nlm.nih.gov/42593582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,40535802,Pan-cancer analysis identifies DBF4B as an immunologic and prognostic biomarker.,2025,10.7150/jca.109134,https://pubmed.ncbi.nlm.nih.gov/40535802/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,40658797,A Trade-Off between Body Mass and Cancer Resistance in Cetaceans Is Mediated by Cell Cycle-Related Gene Evolution.,2025,10.1093/molbev/msaf159,https://pubmed.ncbi.nlm.nih.gov/40658797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,41331242,Regulated TRESLIN-MTBP loading governs initiation zones and replication timing in human DNA replication.,2025,10.1038/s41467-025-66278-7,https://pubmed.ncbi.nlm.nih.gov/41331242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,38865090,"DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.",2024,10.1083/jcb.202402144,https://pubmed.ncbi.nlm.nih.gov/38865090/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,42861757,Identification of Key Genes and Construction of miRNA-mRNA Regulatory Networks Associated with Glioma Grade by Bioinformatics Analysis.,2026,10.2174/0109298673468802260903111711,https://pubmed.ncbi.nlm.nih.gov/42861757/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,36609254,Analysis of the expression and prognostic significance of DDK complex in Hepatocarcinoma.,2023,10.1186/s12885-022-10475-w,https://pubmed.ncbi.nlm.nih.gov/36609254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,37497004,DBF4 Dependent Kinase Inhibition Suppresses Hepatocellular Carcinoma Progression and Potentiates Anti-Programmed Cell Death-1 Therapy.,2023,10.7150/ijbs.80351,https://pubmed.ncbi.nlm.nih.gov/37497004/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,38850431,An Immature NK Cell Compartment in Functional DBF4 Deficiency.,2024,10.1007/s10875-024-01750-5,https://pubmed.ncbi.nlm.nih.gov/38850431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,38580643,Seeding the meiotic DNA break machinery and initiating recombination on chromosome axes.,2024,10.1038/s41467-024-47020-1,https://pubmed.ncbi.nlm.nih.gov/38580643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,41864930,A 13-gene prognostic model developed using machine learning to predict the response to neoadjuvant chemoradiotherapy in rectal carcinoma.,2026,10.1186/s12935-026-04256-9,https://pubmed.ncbi.nlm.nih.gov/41864930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,35477717,Author Correction: Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase.,2022,10.1038/s41467-022-30188-9,https://pubmed.ncbi.nlm.nih.gov/35477717/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,38471272,The role of Akkermansia muciniphila in colorectal cancer: A double-edged sword of treatment or disease progression?,2024,10.1016/j.biopha.2024.116416,https://pubmed.ncbi.nlm.nih.gov/38471272/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,35296675,Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase.,2022,10.1038/s41467-022-29070-5,https://pubmed.ncbi.nlm.nih.gov/35296675/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,35850776,Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer.,2022,10.1186/s13058-022-01542-y,https://pubmed.ncbi.nlm.nih.gov/35850776/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,38844751,Restricting the level of the proteins essential for the regulation of the initiation step of replication extends the chronological lifespan and reproductive potential in budding yeast.,2024,10.1007/s10522-024-10113-x,https://pubmed.ncbi.nlm.nih.gov/38844751/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,31289205,Kinome expression profiling to target new therapeutic avenues in multiple myeloma.,2020,10.3324/haematol.2018.208306,https://pubmed.ncbi.nlm.nih.gov/31289205/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,32295767,Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae.,2020,10.1534/g3.120.401131,https://pubmed.ncbi.nlm.nih.gov/32295767/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,35220396,CDC7 kinase (DDK) inhibition disrupts DNA replication leading to mitotic catastrophe in Ewing sarcoma.,2022,10.1038/s41420-022-00877-x,https://pubmed.ncbi.nlm.nih.gov/35220396/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,36325324,β-Carboline dimers inhibit the tumor proliferation by the cell cycle arrest of sarcoma through intercalating to Cyclin-A2.,2022,10.3389/fimmu.2022.922183,https://pubmed.ncbi.nlm.nih.gov/36325324/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,35524559,Convergence of SIRT1 and ATR signaling to modulate replication origin dormancy.,2022,10.1093/nar/gkac299,https://pubmed.ncbi.nlm.nih.gov/35524559/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,30293817,Identification of Novel Cdc7 Kinase Inhibitors as Anti-Cancer Agents that Target the Interaction with Dbf4 by the Fragment Complementation and Drug Repositioning Approach.,2018,10.1016/j.ebiom.2018.09.030,https://pubmed.ncbi.nlm.nih.gov/30293817/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,34326198,Activation of the ABCB1 Amplicon in Docetaxel- and Cabazitaxel-Resistant Prostate Cancer Cells.,2021,10.1158/1535-7163.mct-20-0983,https://pubmed.ncbi.nlm.nih.gov/34326198/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,34781924,The construction and analysis of ceRNA network and patterns of immune infiltration in lung adenocarcinoma.,2021,10.1186/s12885-021-08932-z,https://pubmed.ncbi.nlm.nih.gov/34781924/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DBF4,ENSG00000006634,Unsafe,10373557,"A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells.",1999,10.1128/mcb.19.7.5083,https://pubmed.ncbi.nlm.nih.gov/10373557/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF12L1,ENSG00000198889,Unsafe,35850260,DDB1- and CUL4-associated factor 12-like protein 1 (Dcaf12l1) is not essential for male fertility in mice.,2022,10.1016/j.ydbio.2022.07.006,https://pubmed.ncbi.nlm.nih.gov/35850260/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF12L1,ENSG00000198889,Unsafe,39383947,Profiling Cullin4-E3 Ligases Interactomes and Their Rewiring in Influenza A Virus Infection.,2024,10.1016/j.mcpro.2024.100856,https://pubmed.ncbi.nlm.nih.gov/39383947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF12L1,ENSG00000198889,Unsafe,35002309,Development of Potential Prognostic Biomarkers Based on DNA Methylation-Driven Genes for Patients with Endometrial Cancer.,2021,10.2147/ijgm.s341771,https://pubmed.ncbi.nlm.nih.gov/35002309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF12L1,ENSG00000198889,Unsafe,37363398,Screening and validation of potential markers associated with uterine corpus endometrial carcinoma and polycystic ovary syndrome based on bioinformatics methods.,2023,10.3389/fmolb.2023.1192313,https://pubmed.ncbi.nlm.nih.gov/37363398/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF12L1,ENSG00000198889,Unsafe,38233393,"X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements.",2024,10.1038/s41467-024-44709-1,https://pubmed.ncbi.nlm.nih.gov/38233393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF12L1,ENSG00000198889,Unsafe,31281445,Investigation of the underling mechanism of ketamine for antidepressant effects in treatment-refractory affective disorders via molecular profile analysis.,2019,10.3892/etm.2019.7633,https://pubmed.ncbi.nlm.nih.gov/31281445/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF12L1,ENSG00000198889,Unsafe,25064398,Integrative DNA methylation and gene expression analysis identifies discoidin domain receptor 1 association with idiopathic nonobstructive azoospermia.,2014,10.1016/j.fertnstert.2014.06.028,https://pubmed.ncbi.nlm.nih.gov/25064398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF12L1,ENSG00000198889,Unsafe,29360682,Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.,2018,10.1097/fpc.0000000000000326,https://pubmed.ncbi.nlm.nih.gov/29360682/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF12L1,ENSG00000198889,Unsafe,26740066,Does mouse embryo primordial germ cell activation start before implantation as suggested by single-cell transcriptomics dynamics?,2016,10.1093/molehr/gav072,https://pubmed.ncbi.nlm.nih.gov/26740066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF8L1,ENSG00000226372,Unsafe,40239542,DCAF8L1 induces branching morphogenesis and hollow acinar structures remodeling of MCF10A cells in 3D culture by upregulating DDR1.,2025,10.1016/j.bbrc.2025.151713,https://pubmed.ncbi.nlm.nih.gov/40239542/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF8L1,ENSG00000226372,Unsafe,35280675,CRL4-DCAF8L1 Regulates BRCA1 and BARD1 Protein Stability.,2022,10.7150/ijbs.57178,https://pubmed.ncbi.nlm.nih.gov/35280675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF8L1,ENSG00000226372,Unsafe,38457199,Comparison of genomic alterations in Epstein-Barr virus-positive and Epstein-Barr virus-negative diffuse large B-cell lymphoma.,2024,10.1002/cam4.6995,https://pubmed.ncbi.nlm.nih.gov/38457199/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCAF8L1,ENSG00000226372,Unsafe,36714595,"Overweight/obesity-related transcriptomic signature as a correlate of clinical outcome, immune microenvironment, and treatment response in hepatocellular carcinoma.",2022,10.3389/fendo.2022.1061091,https://pubmed.ncbi.nlm.nih.gov/36714595/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,42753319,Predicting risk of ischemic stroke: A transformer model using genomic data.,2026,10.1016/j.cmpb.2026.109625,https://pubmed.ncbi.nlm.nih.gov/42753319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,42302885,Regulation of the yolk microtubule and actin cytoskeleton by Dachsous cadherins during zebrafish epiboly.,2026,10.1016/j.ydbio.2026.06.003,https://pubmed.ncbi.nlm.nih.gov/42302885/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,41989867,"Sex-specific genetic drivers of memory, executive functioning and language in older adults.",2026,10.1093/brain/awag134,https://pubmed.ncbi.nlm.nih.gov/41989867/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,41670256,Longitudinal Genome-Wide Association Study for Female Fertility Traits in German Holstein Cattle.,2026,10.1002/age.70078,https://pubmed.ncbi.nlm.nih.gov/41670256/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,41299996,"Integrative Analysis of Flavoromics, Lipidomics, and Transcriptomics Reveals the Potential Mechanisms Underlying the Unique Meat Flavor of Jianli Pigs.",2025,10.3390/foods14223838,https://pubmed.ncbi.nlm.nih.gov/41299996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,41873429,Clinical and genetic basis of congenital gonadotropin deficiency.,2026,10.1093/hropen/hoag017,https://pubmed.ncbi.nlm.nih.gov/41873429/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,38699454,Novel missense variants in brain morphogenic genes associated with depression and schizophrenia.,2024,10.3389/fpsyt.2024.1338168,https://pubmed.ncbi.nlm.nih.gov/38699454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,41001426,Stratification by Mutational Landscape Reveals Differential Immune Infiltration and Predicts the Recurrence and Clinical Outcome of Cervical Cancer.,2025,10.1007/s43657-024-00158-w,https://pubmed.ncbi.nlm.nih.gov/41001426/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,39958158,Revealing study and breeding implications for production traits and tail characteristics in Simmental cattle by GWAS.,2025,10.3389/fgene.2025.1491816,https://pubmed.ncbi.nlm.nih.gov/39958158/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,37119967,Regulation of Sertoli cell function by planar cell polarity (PCP) protein Fjx1.,2023,10.1016/j.mce.2023.111936,https://pubmed.ncbi.nlm.nih.gov/37119967/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,35114812,lncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth.,2022,10.1161/circulationaha.121.056850,https://pubmed.ncbi.nlm.nih.gov/35114812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,41559577,"Population structure, regions of homozygosity (ROH) and selection signal of two domesitic goat breeds revealed by whole-genome resequencing.",2026,10.1186/s12864-025-12418-8,https://pubmed.ncbi.nlm.nih.gov/41559577/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,33108146,Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development.,2020,10.1172/jci.insight.134310,https://pubmed.ncbi.nlm.nih.gov/33108146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,37709376,Identification of potential circadian genes and associated pathways in colorectal cancer progression and prognosis using microarray gene expression analysis.,2023,10.1016/bs.apcsb.2023.02.011,https://pubmed.ncbi.nlm.nih.gov/37709376/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,35975176,Comprehensive Analysis of Genomic and Expression Data Identified Potential Markers for Predicting Prognosis and Immune Response in CRC.,2022,10.1155/2022/1831211,https://pubmed.ncbi.nlm.nih.gov/35975176/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,37240136,Are Genetic Modifiers the Answer to Different Responses to Hydroxyurea Treatment?-A Pharmacogenetic Study in Sickle Cell Anemia Angolan Children.,2023,10.3390/ijms24108792,https://pubmed.ncbi.nlm.nih.gov/37240136/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,38192023,Whole-exome sequencing of Nigerian benign prostatic hyperplasia reveals increased alterations in apoptotic pathways.,2024,10.1002/pros.24662,https://pubmed.ncbi.nlm.nih.gov/38192023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,33593615,A genome-wide association study of facial morphology identifies novel genetic loci in Han Chinese.,2021,10.1016/j.jgg.2020.10.004,https://pubmed.ncbi.nlm.nih.gov/33593615/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,35876323,Whole genome sequencing and inheritance-based variant filtering as a tool for unraveling missing heritability in pediatric cancer.,2023,10.1080/08880018.2022.2101723,https://pubmed.ncbi.nlm.nih.gov/35876323/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,31446181,Expression Levels of 4 Genes in Colon Tissue Might Be Used to Predict Which Patients Will Enter Endoscopic Remission After Vedolizumab Therapy for Inflammatory Bowel Diseases.,2020,10.1016/j.cgh.2019.08.030,https://pubmed.ncbi.nlm.nih.gov/31446181/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCHS2,ENSG00000197410,Unsafe,15003449,Identification of new human cadherin genes using a combination of protein motif search and gene finding methods.,2004,10.1016/j.jmb.2004.01.026,https://pubmed.ncbi.nlm.nih.gov/15003449/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,42176245,Rat DCST1 and DCST2 are essential for sperm-egg fusion†.,2026,10.1093/biolre/ioag111,https://pubmed.ncbi.nlm.nih.gov/42176245/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,41299565,DCST1-AS1 promotes renal cell carcinoma progression via regulating the miR-582-5p/HMGB2 axis.,2025,10.1186/s12967-025-07403-4,https://pubmed.ncbi.nlm.nih.gov/41299565/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,40711049,"Impact of Polystyrene Microplastics on Human Sperm Functionality: An In Vitro Study of Cytotoxicity, Genotoxicity and Fertility-Related Genes Expression.",2025,10.3390/toxics13070605,https://pubmed.ncbi.nlm.nih.gov/40711049/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,42229001,Deciphering transcriptomic insights into climate adaptation in Etroplus suratensis (pearl spot) under combined thermal-saline stress.,2026,10.1016/j.aquatox.2026.107876,https://pubmed.ncbi.nlm.nih.gov/42229001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,38063091,LncRNA DCST1-AS1 drives the malignant progression of pediatric acute myeloid leukemia via regulating p53 methylation.,2023,10.14715/cmb/2023.69.12.32,https://pubmed.ncbi.nlm.nih.gov/38063091/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,35393517,Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish.,2022,10.1038/s42003-022-03289-w,https://pubmed.ncbi.nlm.nih.gov/35393517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,40058809,Molecular mechanisms leading to gamete fusion.,2025,10.5387/fms.24-00046,https://pubmed.ncbi.nlm.nih.gov/40058809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,41420529,Interaction Between Activating Transcription Factor 4 and Interleukin 6 Dictates Osteoclast Differentiation and Activity.,2025,10.1096/fj.202503503r,https://pubmed.ncbi.nlm.nih.gov/41420529/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,41089504,Case Report: Novel findings of larotrectinib in children with &lt;i&gt;NTRK&lt;/i&gt;-rearranged spindle cell tumor.,2025,10.3389/fonc.2025.1561051,https://pubmed.ncbi.nlm.nih.gov/41089504/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,34967274,Long non-coding RNA DCST1-AS1/hsa-miR-582-5p/HMGB1 axis regulates colorectal cancer progression.,2022,10.1080/21655979.2021.1976894,https://pubmed.ncbi.nlm.nih.gov/34967274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,40936780,Antisense RNAs (asRNAs) as key players in gallbladder cancer progression: a bioinformatics analysis.,2025,10.22037/ghfbb.v18i2.3002,https://pubmed.ncbi.nlm.nih.gov/40936780/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,33871360,"Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion.",2021,10.7554/elife.66313,https://pubmed.ncbi.nlm.nih.gov/33871360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,34497766,LncRNA DCST1-AS1 Promotes Endometrial Cancer Progression by Modulating the MiR-665/HOXB5 and MiR-873-5p/CADM1 Pathways.,2021,10.3389/fonc.2021.714652,https://pubmed.ncbi.nlm.nih.gov/34497766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,39080678,Is cross-species horizontal gene transfer responsible for gallbladder carcinogenesis.,2024,10.1186/s12957-024-03492-5,https://pubmed.ncbi.nlm.nih.gov/39080678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,31897227,Long Noncoding RNA DCST1-AS1 Promotes Cell Proliferation and Metastasis in Triple-negative Breast Cancer by Forming a Positive Regulatory Loop with miR-873-5p and MYC.,2020,10.7150/jca.33982,https://pubmed.ncbi.nlm.nih.gov/31897227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,33533513,LncRNA DCST1-AS1 inhibits PDLCs' proliferation in periodontitis and may bind with miR-21 precursor to upregulate PLAP-1.,2021,10.1111/jre.12809,https://pubmed.ncbi.nlm.nih.gov/33533513/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,32418155,LncRNA DCST1-AS1 downregulates miR-29b through methylation in glioblastoma (GBM) to promote cancer cell proliferation.,2020,10.1007/s12094-020-02363-1,https://pubmed.ncbi.nlm.nih.gov/32418155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,34414241,lncRNA DCST1-AS1 Facilitates Oral Squamous Cell Carcinoma by Promoting M2 Macrophage Polarization through Activating NF-κB Signaling.,2021,10.1155/2021/5524231,https://pubmed.ncbi.nlm.nih.gov/34414241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,37453426,The EGF-motif-containing protein SPE-36 is a secreted sperm protein required for fertilization in C. elegans.,2023,10.1016/j.cub.2023.06.051,https://pubmed.ncbi.nlm.nih.gov/37453426/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,39149042,"Implications of m5C modifications in ribosomal proteins on oxidative stress, metabolic reprogramming, and immune responses in patients with mid-to-late-stage head and neck squamous cell carcinoma: Insights from nanopore sequencing.",2024,10.1016/j.heliyon.2024.e34529,https://pubmed.ncbi.nlm.nih.gov/39149042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,36212154,Construction of a cancer-associated fibroblasts-related long non-coding RNA signature to predict prognosis and immune landscape in pancreatic adenocarcinoma.,2022,10.3389/fgene.2022.989719,https://pubmed.ncbi.nlm.nih.gov/36212154/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCST1,ENSG00000163357,Unsafe,27782195,Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling.,2016,10.1038/srep36179,https://pubmed.ncbi.nlm.nih.gov/27782195/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCUN1D4,ENSG00000109184,Unsafe,35175191,Whole transcriptome analysis of platelet concentrates during storage.,2023,10.2450/2022.0291-21,https://pubmed.ncbi.nlm.nih.gov/35175191/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCUN1D4,ENSG00000109184,Unsafe,39943155,"Resequencing Composite Kazakh Whiteheaded Cattle: Insights into Ancestral Breed Contributions, Selection Signatures, and Candidate Genetic Variants.",2025,10.3390/ani15030385,https://pubmed.ncbi.nlm.nih.gov/39943155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCUN1D4,ENSG00000109184,Unsafe,33425493,circDCUN1D4 suppresses tumor metastasis and glycolysis in lung adenocarcinoma by stabilizing TXNIP expression.,2021,10.1016/j.omtn.2020.11.012,https://pubmed.ncbi.nlm.nih.gov/33425493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCUN1D4,ENSG00000109184,Unsafe,33428145,Identification of Serum Exosomal MicroRNA Expression Profiling in Menopausal Females with Osteoporosis by High-throughput Sequencing.,2020,10.1007/s11596-020-2306-x,https://pubmed.ncbi.nlm.nih.gov/33428145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42767292,"New small isoform of glial cell line-derived neurotrophic factor djGDNF47 promotes neuronal viability, differentiation, and adult neurogenesis: Evidence from in vitro and in vivo models.",2026,10.1016/j.ijbiomac.2026.154555,https://pubmed.ncbi.nlm.nih.gov/42767292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42829103,Loss of Cotl1 disrupts mitochondrial fission and impairs learning and memory in mice.,2026,10.1016/j.lfs.2026.124720,https://pubmed.ncbi.nlm.nih.gov/42829103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42876150,Distribution of doublecortin in the developing retina of birds: A comparative analysis.,2026,10.1002/ar.70382,https://pubmed.ncbi.nlm.nih.gov/42876150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42894868,"Rare Xq23 Microdeletion Involving the DCX and PAK3 Genes Presenting With Lissencephaly, Agenesis of the Corpus Callosum, and Intractable Epilepsy: A Case Report.",2026,10.7759/cureus.116506,https://pubmed.ncbi.nlm.nih.gov/42894868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42589353,"Immature Neurons in the Postnatal Brain: Markers, Modulation, and Involvement in Normal and Aberrant Plasticity.",2026,10.3390/ijms27156696,https://pubmed.ncbi.nlm.nih.gov/42589353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42650653,"Impact of Imipenem on Cognitive Function, Anxiety-like Behaviour, Neurogenesis, and Astrogliosis in Pentylenetetrazol-Kindled Rats.",2026,10.3390/antibiotics15080728,https://pubmed.ncbi.nlm.nih.gov/42650653/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42502106,Vitamin a modulates neurogenesis-associated pathways and cholinergic signaling in Alzheimer's disease: potential role of reactive astrocytes via NGN2/SOX-11 and SIRT-1.,2026,10.1038/s41598-026-55386-z,https://pubmed.ncbi.nlm.nih.gov/42502106/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,41936722,Postnatal plasticity in the paralaminar nucleus of the pallial amygdala in juvenile swine brain.,2026,10.1007/s00429-026-03106-8,https://pubmed.ncbi.nlm.nih.gov/41936722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42690475,Da chuanxiong formula improves vascular remodeling via promoting angiogenesis and vasodilation mediated by PI3K/Akt/eNOS signaling.,2026,10.1007/s11011-026-01974-x,https://pubmed.ncbi.nlm.nih.gov/42690475/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42807785,Disturbed Spatial Learning and Hippocampal Molecular and Histological Alterations in Middle-Aged Rats with a History of Polycystic Ovary Syndrome.,2027,10.5812/ijem-167083,https://pubmed.ncbi.nlm.nih.gov/42807785/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42602088,Electroacupuncture improves neurocognitive impairment induced by chronic sleep deprivation: an experimental study based on hippocampal neurogenesis and synaptic plasticity.,2026,10.3389/fnhum.2026.1857669,https://pubmed.ncbi.nlm.nih.gov/42602088/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42793349,KLF2 Is Associated with ERK1/2-MAP2 Activation and Neuron-like Phenotypic Remodeling of PDGFR-β-Lineage Cells Following Ischemic Stroke.,2026,10.3390/brainsci16090924,https://pubmed.ncbi.nlm.nih.gov/42793349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42720581,Genome-Wide Association Analysis of Hippocampal Neuroplasticity as an Indicator of Stress Responsiveness in Laying Hens (Gallus gallus domesticus).,2026,10.1002/age.70202,https://pubmed.ncbi.nlm.nih.gov/42720581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,41562755,Moderate Exercise Stimulates PACAP-Mediated Neurogenesis in Rat Dentate Gyrus and Cerebellar Cortex.,2026,10.3390/jfmk11010037,https://pubmed.ncbi.nlm.nih.gov/41562755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42321187,Blood IL-6 is a critical trigger of depressive symptoms in a mouse model for human atopic dermatitis.,2026,10.1038/s41398-026-04211-2,https://pubmed.ncbi.nlm.nih.gov/42321187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42221773,Intermittent fasting alleviates irradiation-induced neuronal mitochondrial damage in mice.,2026,10.3389/fnut.2026.1815146,https://pubmed.ncbi.nlm.nih.gov/42221773/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42446595,Maternal Isocaloric Monosaccharide Diets Reorganize Dorsal-Ventral Hippocampal Maturation and Ventral Plasticity in Rat Offspring.,2026,10.1007/s10571-026-01781-z,https://pubmed.ncbi.nlm.nih.gov/42446595/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42247190,Identification of hub mRNAs and long non-coding RNAs involved in temozolomide-resistant glioblastoma (brain cancer) cell lines.,2026,10.1007/s12672-026-05243-2,https://pubmed.ncbi.nlm.nih.gov/42247190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,41151701,Metabolomics reveals that Da Chuanxiong Formula ameliorates cerebral ischemia/reperfusion injury via regulating membrane phospholipid homeostasis.,2025,10.1016/j.brainresbull.2025.111605,https://pubmed.ncbi.nlm.nih.gov/41151701/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42749069,Streptozotocin-induced diabetes during gestation and post-partum: effects on behavior and hippocampal plasticity in female Wistar rats.,2026,10.1016/j.physbeh.2026.115508,https://pubmed.ncbi.nlm.nih.gov/42749069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,41506372,Flagella-overexpressing bacteria with inducible lysis capability delivering cGAMP intratracheally for enhanced anticancer immunotherapy.,2026,10.1016/j.jconrel.2026.114606,https://pubmed.ncbi.nlm.nih.gov/41506372/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42706972,Scutellaria Barbata Flavonoids Mitigate Alzheimer's Disease-related Aβ25-35 Toxicity in N2a Cells through CREB Phosphorylation.,2026,10.2174/0109298673438931260822121059,https://pubmed.ncbi.nlm.nih.gov/42706972/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,40818614,DCX&lt;sup&gt;+&lt;/sup&gt; cells cripple systemic spleen immunity and promote tumor progression.,2025,10.1016/j.bbi.2025.106076,https://pubmed.ncbi.nlm.nih.gov/40818614/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42172708,Maternal triclosan exposure impairs female offspring neurodevelopment via MeCP2 hypomethylation and enhanced MeCP2/HDAC3 interaction.,2026,10.1016/j.ecoenv.2026.120282,https://pubmed.ncbi.nlm.nih.gov/42172708/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42691624,Perfluorooctane sulfonate (PFOS) exposure alters developmental and metabolic gene expression in human hippocampal organoids.,2026,10.1016/j.bbrc.2026.154534,https://pubmed.ncbi.nlm.nih.gov/42691624/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,36897187,Remodeling Tumor Immunogenicity with Dual-Activatable Binary CRISPR Nanomedicine for Cancer Immunotherapy.,2023,10.1021/acsnano.2c12107,https://pubmed.ncbi.nlm.nih.gov/36897187/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42138821,The Effect of Saffron Extract Supplementation During Resistance Training on Hippocampal Doublecortin and Hepatic β-Hydroxybutyrate Levels in Rats With Type 2 Diabetes.,2026,10.1155/jdr/1914865,https://pubmed.ncbi.nlm.nih.gov/42138821/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,41482153,Low Intensity Ultrasound-facilitated exosome delivery promotes hippocampal neurogenesis in Alzheimer's disease.,2026,10.1016/j.brs.2025.103015,https://pubmed.ncbi.nlm.nih.gov/41482153/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,40006531,"Development, Characterization, and Evaluation of Chi-Tn mAb-Functionalized DOTAP-PLGA Hybrid Nanoparticles Loaded with Docetaxel for Lung Cancer Therapy.",2025,10.3390/pharmaceutics17020164,https://pubmed.ncbi.nlm.nih.gov/40006531/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,41890913,Sodium pyruvate ameliorates cognitive dysfunction by expanding hippocampal endogenous neural stem cells in tBCCAO mice.,2026,10.3389/fcell.2026.1782699,https://pubmed.ncbi.nlm.nih.gov/41890913/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,41600627,Integrated Profiling of DEHP-Induced Hippocampal Neurotoxicity in Adult Female Rats Based on Transcriptomic and Neurobiological Analyses.,2026,10.3390/toxics14010079,https://pubmed.ncbi.nlm.nih.gov/41600627/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,41825555,"Differential effects and underlying mechanisms of voluntary, forced, and combined exercise on ameliorating Alzheimer's disease pathophenotypes.",2026,10.1016/j.expneurol.2026.115731,https://pubmed.ncbi.nlm.nih.gov/41825555/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42457661,Fatigue after COVID-19 infection is associated with peripheral immunometabolic alterations affecting neuroimmune responses in the hippocampus.,2026,10.1038/s41398-026-04250-9,https://pubmed.ncbi.nlm.nih.gov/42457661/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,42390034,Chronic Low-Dose Cadmium Exposure Impairs Adult Hippocampal Neurogenesis by Suppressing Noncanonical Wnt5a Signaling.,2026,10.1002/jat.70325,https://pubmed.ncbi.nlm.nih.gov/42390034/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DCX,ENSG00000077279,Unsafe,41809513,Sex differences in neurobehavior and the adult hippocampal neurogenic niche: influence of traumatic brain injury and CLIP antagonism.,2026,10.3389/fnbeh.2026.1768730,https://pubmed.ncbi.nlm.nih.gov/41809513/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,42736378,APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease.,2026,10.1038/s41588-026-02713-9,https://pubmed.ncbi.nlm.nih.gov/42736378/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,40593136,Role of lysine acetylation-related genes in the diagnosis and prognosis of glioma.,2025,10.1038/s41598-025-07738-4,https://pubmed.ncbi.nlm.nih.gov/40593136/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,39650190,Identifying biomarkers of endoplasmic reticulum stress and analyzing immune cell infiltration in chronic obstructive pulmonary disease using machine learning.,2024,10.3389/fmed.2024.1462868,https://pubmed.ncbi.nlm.nih.gov/39650190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,38203716,Proof-of-Concept Study on the Use of Tangerine-Derived Nanovesicles as siRNA Delivery Vehicles toward Colorectal Cancer Cell Line SW480.,2023,10.3390/ijms25010546,https://pubmed.ncbi.nlm.nih.gov/38203716/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,39505896,AS160 is a lipid-responsive regulator of cardiac Ca&lt;sup&gt;2+&lt;/sup&gt; homeostasis by controlling lysophosphatidylinositol metabolism and signaling.,2024,10.1038/s41467-024-54031-5,https://pubmed.ncbi.nlm.nih.gov/39505896/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,37189713,Oleic Acid-Containing Phosphatidylinositol Is a Blood Biomarker Candidate for SPG28.,2023,10.3390/biomedicines11041092,https://pubmed.ncbi.nlm.nih.gov/37189713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,34089703,Phosphorylation of human phospholipase A1 DDHD1 at newly identified phosphosites affects its subcellular localization.,2021,10.1016/j.jbc.2021.100851,https://pubmed.ncbi.nlm.nih.gov/34089703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,33600578,Ddhd1 knockout mouse as a model of locomotive and physiological abnormality in familial spastic paraplegia.,2021,10.1042/bsr20204171,https://pubmed.ncbi.nlm.nih.gov/33600578/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,40303507,Multiomics Approach Reveal Novel Insights in FUS Driven Juvenile Amyotrophic Lateral Sclerosis: A Family Quartet Analysis.,2025,10.1177/09727531231194399,https://pubmed.ncbi.nlm.nih.gov/40303507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,30221923,The Spastic Paraplegia-Associated Phospholipase DDHD1 Is a Primary Brain Phosphatidylinositol Lipase.,2018,10.1021/acs.biochem.8b00810,https://pubmed.ncbi.nlm.nih.gov/30221923/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,38023824,Identification of a Prognostic Gene Signature Based on Lipid Metabolism-Related Genes in Esophageal Squamous Cell Carcinoma.,2023,10.2147/pgpm.s430786,https://pubmed.ncbi.nlm.nih.gov/38023824/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,39570887,Genomic prediction and genome-wide association studies of morphological traits and distraction index in Korean Sapsaree dogs.,2024,10.1371/journal.pone.0312583,https://pubmed.ncbi.nlm.nih.gov/39570887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,32850804,"DDHD1, but Not DDHD2, Suppresses Neurite Outgrowth in SH-SY5Y and PC12 Cells by Regulating Protein Transport From Recycling Endosomes.",2020,10.3389/fcell.2020.00670,https://pubmed.ncbi.nlm.nih.gov/32850804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,33952459,Expression of Lysophosphatidylinositol Signaling-relevant Molecules in Colorectal Cancer.,2021,10.21873/anticanres.15009,https://pubmed.ncbi.nlm.nih.gov/33952459/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,35458682,"Current Knowledge on Mammalian Phospholipase A1, Brief History, Structures, Biochemical and Pathophysiological Roles.",2022,10.3390/molecules27082487,https://pubmed.ncbi.nlm.nih.gov/35458682/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,35653832,Prenatal exposure to particulate matter and placental gene expression.,2022,10.1016/j.envint.2022.107310,https://pubmed.ncbi.nlm.nih.gov/35653832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,29653539,The phospholipase DDHD1 as a new target in colorectal cancer therapy.,2018,10.1186/s13046-018-0753-z,https://pubmed.ncbi.nlm.nih.gov/29653539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,27999540,A Novel Missense Mutation of the DDHD1 Gene Associated with Juvenile Amyotrophic Lateral Sclerosis.,2016,10.3389/fnagi.2016.00291,https://pubmed.ncbi.nlm.nih.gov/27999540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,28818478,"Mutations in DDHD1, encoding a phospholipase A1, is a novel cause of retinopathy and neurodegeneration with brain iron accumulation.",2017,10.1016/j.ejmg.2017.08.015,https://pubmed.ncbi.nlm.nih.gov/28818478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,32571262,Immune-related genes in tumor-specific CD4+ and CD8+ T cells in colon cancer.,2020,10.1186/s12885-020-07075-x,https://pubmed.ncbi.nlm.nih.gov/32571262/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,30715382,Genome-wide association study identifies QTLs for displacement of abomasum in Chinese Holstein cattle1.,2019,10.1093/jas/skz031,https://pubmed.ncbi.nlm.nih.gov/30715382/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,27488176,Genetic determinants of warfarin maintenance dose and time in therapeutic treatment range: a RE-LY genomics substudy.,2016,10.2217/pgs-2016-0061,https://pubmed.ncbi.nlm.nih.gov/27488176/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,30838228,An Update on the Hereditary Spastic Paraplegias: New Genes and New Disease Models.,2015,10.1002/mdc3.12184,https://pubmed.ncbi.nlm.nih.gov/30838228/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDHD1,ENSG00000100523,Unsafe,9488669,Cloning of a phosphatidic acid-preferring phospholipase A1 from bovine testis.,1998,10.1074/jbc.273.10.5468,https://pubmed.ncbi.nlm.nih.gov/9488669/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,42636811,DDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development.,2026,10.1016/j.cell.2026.07.041,https://pubmed.ncbi.nlm.nih.gov/42636811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,41880091,"Pan-cancer analysis reveals DDIAS as a potential diagnostic biomarker, prognostic indicator, and tumor-immune correlate.",2026,10.1007/s12672-026-04835-2,https://pubmed.ncbi.nlm.nih.gov/41880091/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,41052043,DDIAS promotes endometrial cancer progression via β-catenin signaling.,2025,10.1371/journal.pone.0331851,https://pubmed.ncbi.nlm.nih.gov/41052043/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,40389420,NAT10 promotes hepatocellular carcinoma progression by modulating the ac4C-DDIAS-PI3K-Akt axis.,2025,10.1038/s41598-025-00707-x,https://pubmed.ncbi.nlm.nih.gov/40389420/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,38545470,DNA Damage-Induced Apoptosis Suppressor Triggers Progression and Stemness of Glioma by Enhancing Lymphoid Enhancer-Binding Factor 1 Expression.,2024,10.14740/wjon1754,https://pubmed.ncbi.nlm.nih.gov/38545470/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,37121974,"DDIAS, DNA damage-induced apoptosis suppressor, is a potential therapeutic target in cancer.",2023,10.1038/s12276-023-00974-6,https://pubmed.ncbi.nlm.nih.gov/37121974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,41197447,Development of multiple cell death pattern features to predict prognosis and drug sensitivity in gastric adenocarcinoma.,2026,10.1016/j.tranon.2025.102584,https://pubmed.ncbi.nlm.nih.gov/41197447/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,39293834,DDIAS Regulation of STAT3/CCL2 Promotes Macrophage Polarization to M1 type in Kawasaki Disease.,2024,,https://pubmed.ncbi.nlm.nih.gov/39293834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,37575689,"Expression of DR4, DR5, FAS, Caspase-8 and, DDIAS Genes in AML Patients.",2023,10.47176/mjiri.37.68,https://pubmed.ncbi.nlm.nih.gov/37575689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,42456411,"5-Fluorouracil loaded copper‑aluminum layered double hydroxides inhibit colorectal cancer cells by inducing oxidative stress, mitochondrial membrane depolarization, apoptosis, and cell cycle arrest.",2026,10.1016/j.bioorg.2026.110241,https://pubmed.ncbi.nlm.nih.gov/42456411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,39361370,Novel risk loci for COVID-19 hospitalization among admixed American populations.,2024,10.7554/elife.93666,https://pubmed.ncbi.nlm.nih.gov/39361370/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,39760809,Identification and Validation of Alkaliptosis Resistance-Associated Genes in Prostate Cancer Via Transcriptome Sequencing and Prediction of Biochemical Recurrence.,2026,10.1007/s12033-024-01322-3,https://pubmed.ncbi.nlm.nih.gov/39760809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,31900385,DDIAS promotes STAT3 activation by preventing STAT3 recruitment to PTPRM in lung cancer cells.,2020,10.1038/s41389-019-0187-2,https://pubmed.ncbi.nlm.nih.gov/31900385/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,33859351,DGG-100629 inhibits lung cancer growth by suppressing the NFATc1/DDIAS/STAT3 pathway.,2021,10.1038/s12276-021-00601-2,https://pubmed.ncbi.nlm.nih.gov/33859351/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,37773064,Mechanical stretch promotes apoptosis and impedes ciliogenesis of primary human airway basal stem cells.,2023,10.1186/s12931-023-02528-w,https://pubmed.ncbi.nlm.nih.gov/37773064/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,26740967,NFATc1 regulates the transcription of DNA damage-induced apoptosis suppressor.,2015,10.1016/j.dib.2015.11.011,https://pubmed.ncbi.nlm.nih.gov/26740967/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,32476221,Miconazole inhibits signal transducer and activator of transcription 3 signaling by preventing its interaction with DNA damage-induced apoptosis suppressor.,2020,10.1111/cas.14432,https://pubmed.ncbi.nlm.nih.gov/32476221/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,26493727,"DNA damage-induced apoptosis suppressor (DDIAS), a novel target of NFATc1, is associated with cisplatin resistance in lung cancer.",2016,10.1016/j.bbamcr.2015.10.011,https://pubmed.ncbi.nlm.nih.gov/26493727/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,35681031,PSPC1 is a potential prognostic marker for hormone-dependent breast cancer patients and modulates RNA processing of ESR1 and SCFD2.,2022,10.1038/s41598-022-13601-7,https://pubmed.ncbi.nlm.nih.gov/35681031/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,40636569,Altered expression in liver cancer with various hepatic blood flow occlusions: A pilot RNA sequencing study.,2023,10.1016/j.iliver.2023.04.001,https://pubmed.ncbi.nlm.nih.gov/40636569/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,37711550,Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition.,2023,10.3389/fcvm.2023.1187490,https://pubmed.ncbi.nlm.nih.gov/37711550/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,31492561,Development and validation of a CIMP-associated prognostic model for hepatocellular carcinoma.,2019,10.1016/j.ebiom.2019.08.064,https://pubmed.ncbi.nlm.nih.gov/31492561/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,26876971,Community Sewage Sensors towards Evaluation of Drug Use Trends: Detection of Cocaine in Wastewater with DNA-Directed Immobilization Aptamer Sensors.,2016,10.1038/srep21024,https://pubmed.ncbi.nlm.nih.gov/26876971/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDIAS,ENSG00000165490,Unsafe,24214091,Human Noxin is an anti-apoptotic protein in response to DNA damage of A549 non-small cell lung carcinoma.,2014,10.1002/ijc.28600,https://pubmed.ncbi.nlm.nih.gov/24214091/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,42581185,A novel CAF population coordinates hyper-suppressive regulatory T cell recruitment and localization in lung cancer.,2026,10.1038/s41590-026-02607-2,https://pubmed.ncbi.nlm.nih.gov/42581185/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,41996023,DDX11-AS1 regulates cell cycle signaling pathway and promotes proliferation and migration of lung adenocarcinoma by sponging miR-30a-5p and targeting CCNA2.,2026,10.1007/s13353-026-01052-z,https://pubmed.ncbi.nlm.nih.gov/41996023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,41050080,Competitive Sequestration of miR-1183 by lncRNA DDX11-AS1 Drives Gliomagenesis through E2F7 Activation.,2025,10.32604/or.2025.065380,https://pubmed.ncbi.nlm.nih.gov/41050080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,42627080,Study on the role of miR-433-3p in the occurrence and development of endometriosis.,2026,10.1080/15257770.2026.2718818,https://pubmed.ncbi.nlm.nih.gov/42627080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,42348113,Identification of Ferroptosis-related Genes Associated with the Prognosis of Hepatocellular Carcinoma.,2026,10.1007/s12013-026-02096-y,https://pubmed.ncbi.nlm.nih.gov/42348113/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,42107920,Genetic characterization of DDX11 variants identified in a Chinese family with Warsaw breakage syndrome.,2026,10.1016/j.seizure.2026.05.007,https://pubmed.ncbi.nlm.nih.gov/42107920/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,41664698,Novel mechanism of tumor metastasis: DDX11-ATAD5 interaction mediates epithelial-mesenchymal transition to promote gallbladder cancer progression.,2025,10.25259/cytojournal_42_2025,https://pubmed.ncbi.nlm.nih.gov/41664698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,41826389,ALYREF-mediated RNA 5-methylcytosine modification promotes laryngeal cancer progression via stabilizing DDX11 mRNA.,2026,10.1038/s41598-026-43729-9,https://pubmed.ncbi.nlm.nih.gov/41826389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,41489706,DDX11/SKP2 Inhibits Cisplatin Sensitivity in Liver Cancer Cells by Regulating DNA Damage Repair and ER Stress.,2026,10.1007/s12010-025-05516-6,https://pubmed.ncbi.nlm.nih.gov/41489706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,40859772,"DDX11 interacts with PARP1 to facilitate PARylation, thereby promoting gallbladder cancer progression and conferring gemcitabine resistance.",2025,10.3724/abbs.2025155,https://pubmed.ncbi.nlm.nih.gov/40859772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,41853675,A pediatric patient with Warsaw breakage syndrome presenting with epilepsy: a case report and literature review.,2026,10.3389/fnins.2026.1751535,https://pubmed.ncbi.nlm.nih.gov/41853675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,40620651,Predictive value of long non-coding RNA DDX11-AS1 in inflammatory bowel disease and its effect on intestinal mucosal cell function.,2025,10.5114/ceji.2025.149579,https://pubmed.ncbi.nlm.nih.gov/40620651/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,40413757,"Evidence of an unprecedented cytoplasmic function of DDX11, the Warsaw breakage syndrome DNA helicase, in regulating autophagy.",2025,10.1080/15548627.2025.2507617,https://pubmed.ncbi.nlm.nih.gov/40413757/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,40371138,Small protein DDX11-AS1-ORF encoded by lncRNA DDX11-AS1 promotes colorectal cancer progression through VEGFA-activated p38-MAPK pathway.,2025,10.62347/vrje7714,https://pubmed.ncbi.nlm.nih.gov/40371138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,40356690,NRF1-Induced lncRNA DDX11-AS1 Contributes to the Progression of Hepatocellular Carcinoma via Activating CA9 Expression and the MEK/ERK Pathway.,2025,10.2147/jhc.s516656,https://pubmed.ncbi.nlm.nih.gov/40356690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,42440147,SnRNA-seq and genome-wide CRISPR screening define the complete transcriptional trajectory and functional drivers of podocyte stress.,2026,10.1007/s00018-026-06335-6,https://pubmed.ncbi.nlm.nih.gov/42440147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,42882246,Simultaneous Bilateral Cochlear Implantation in a Child with Warsaw Breakage Syndrome and Normal Cochlear Morphology: A Case Report and Focused Literature Review.,2026,10.3390/diagnostics16193092,https://pubmed.ncbi.nlm.nih.gov/42882246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,41008554,Consequences of Adhesion Molecule Close Homolog of L1 Deficiency for Neurons and Glial Cells in the Mouse Spinal Cord After Injury.,2025,10.3390/biom15091247,https://pubmed.ncbi.nlm.nih.gov/41008554/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,35743069,"Chl1, an ATP-Dependent DNA Helicase, Inhibits DNA:RNA Hybrids Formation at DSB Sites to Maintain Genome Stability in S. pombe.",2022,10.3390/ijms23126631,https://pubmed.ncbi.nlm.nih.gov/35743069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,41843490,Expression of Concern: Ezrin interacts with the tumor suppressor CHL1 and promotes neuronal differentiation of human neuroblastoma.,2026,10.1371/journal.pone.0345070,https://pubmed.ncbi.nlm.nih.gov/41843490/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,41696275,Computational and Experimental Verification of Cabozantinib Targeting DDX11 to Inhibit DNA Damage Repair in Liver Cancer.,2026,10.1021/acsomega.5c10093,https://pubmed.ncbi.nlm.nih.gov/41696275/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,42350987,"Expression levels of SARS-CoV-2 IgM, IgG, and neutralizing antibodies in a Chinese cohort and detection of peptide-specific antibodies in COVID-19 patients.",2026,10.1186/s12879-026-13532-y,https://pubmed.ncbi.nlm.nih.gov/42350987/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,40376520,Piperlongumine inhibits renal cell carcinoma progression by modulating the DDX11-miR-15b-3p-DLD axis.,2025,10.21037/tau-2025-11,https://pubmed.ncbi.nlm.nih.gov/40376520/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,41009363,SARS-CoV-2 Spike Protein and Molecular Mimicry: An Immunoinformatic Screen for Cross-Reactive Autoantigen Candidates.,2025,10.3390/ijms26188793,https://pubmed.ncbi.nlm.nih.gov/41009363/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,41531106,Reciprocal co-regulation of nitrate and ammonium transporters is modulated by external pH in Arabidopsis.,2026,10.1093/jxb/erag007,https://pubmed.ncbi.nlm.nih.gov/41531106/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,40213100,Identification of mitochondria-related feature genes for predicting type 2 diabetes mellitus using machine learning methods.,2025,10.3389/fendo.2025.1501159,https://pubmed.ncbi.nlm.nih.gov/40213100/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,36761420,Synthetic lethal interactions of DEAD/H-box helicases as targets for cancer therapy.,2022,10.3389/fonc.2022.1087989,https://pubmed.ncbi.nlm.nih.gov/36761420/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,41364185,The role of ADAM8 in intrahepatic cholangiocarcinoma.,2025,10.1007/s12672-025-04242-z,https://pubmed.ncbi.nlm.nih.gov/41364185/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,41374320,Genomic Characterization of Papillary Thyroid Carcinoma: Age Differences in Tumor Aggressiveness and Immune Infiltration.,2025,10.3390/diagnostics15232937,https://pubmed.ncbi.nlm.nih.gov/41374320/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,38025382,CHL1 depletion affects dopamine receptor D2-dependent modulation of mouse behavior.,2023,10.3389/fnbeh.2023.1288509,https://pubmed.ncbi.nlm.nih.gov/38025382/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,33802088,The Genome Stability Maintenance DNA Helicase DDX11 and Its Role in Cancer.,2021,10.3390/genes12030395,https://pubmed.ncbi.nlm.nih.gov/33802088/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,37512859,Molecular Mimicry and HLA Polymorphisms May Drive Autoimmunity in Recipients of the BNT-162b2 mRNA Vaccine: A Computational Analysis.,2023,10.3390/microorganisms11071686,https://pubmed.ncbi.nlm.nih.gov/37512859/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,41541703,Biochemical and Comparative Proteomic Analyses Delineate the Anti-Ovarian Carcinogenic Roles of Modified Calycosin.,2026,10.1002/fsn3.71338,https://pubmed.ncbi.nlm.nih.gov/41541703/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,38041124,Identifying potential pathogenesis and immune infiltration in diabetic foot ulcers using bioinformatics and in vitro analyses.,2023,10.1186/s12920-023-01741-2,https://pubmed.ncbi.nlm.nih.gov/38041124/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,39577803,Deciphering the toxicity of polyhexamethylene guanidine phosphate in lung carcinogenesis: Mutational profiles and molecular mechanisms.,2024,10.1016/j.chemosphere.2024.143785,https://pubmed.ncbi.nlm.nih.gov/39577803/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,40940928,Effectiveness of Multi-Layer Perceptron-Based Binary Classification Neural Network in Detecting Breast Cancer Through Nine Human Serum Protein Markers.,2025,10.3390/cancers17172832,https://pubmed.ncbi.nlm.nih.gov/40940928/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,36072974,The Clinical Value of Long Noncoding RNA DDX11-AS1 as a Biomarker for the Diagnosis and Prognosis of Hepatocellular Carcinoma.,2022,10.1155/2022/5735462,https://pubmed.ncbi.nlm.nih.gov/36072974/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,23116066,"The DEAD/DEAH box helicase, DDX11, is essential for the survival of advanced melanomas.",2012,10.1186/1476-4598-11-82,https://pubmed.ncbi.nlm.nih.gov/23116066/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,9013641,"Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1.",1997,10.1074/jbc.272.6.3823,https://pubmed.ncbi.nlm.nih.gov/9013641/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX11,ENSG00000013573,Unsafe,8798685,The human homologue of the yeast CHL1 gene is a novel keratinocyte growth factor-regulated gene.,1996,10.1074/jbc.271.40.24337,https://pubmed.ncbi.nlm.nih.gov/8798685/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,42248871,DP103 as a critical modulator of Wnt signaling and cancer stemness: implications for precision treatment in triple negative breast cancer.,2026,10.1038/s41419-026-08943-3,https://pubmed.ncbi.nlm.nih.gov/42248871/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,39924071,A critical genetic interaction between Gemin3/Ddx20 and translation initiation factor NAT1/eIF4G2 drives development.,2025,10.1016/j.ydbio.2025.02.003,https://pubmed.ncbi.nlm.nih.gov/39924071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,41864319,"Ddx20, DEAD-box helicase 20 is essential for maintaining microglial homeostasis.",2026,10.1016/j.expneurol.2026.115743,https://pubmed.ncbi.nlm.nih.gov/41864319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,41101506,African swine fever virus MGF360-9L degrades DDX20 through the Rab1A-dependent autophagy pathway to antagonize its antiviral effect.,2025,10.1016/j.virs.2025.10.001,https://pubmed.ncbi.nlm.nih.gov/41101506/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,41109356,An inducible oligodendrocyte dysfunction triggered a pathological cascade of massive microglial activation and neurodegeneration.,2025,10.1016/j.nbd.2025.107142,https://pubmed.ncbi.nlm.nih.gov/41109356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,42443163,Antisense oligonucleotides treatment uncovers differences in the modulation of dysregulated intracellular pathways in Spinal Muscular Atrophy motoneurons.,2026,10.1038/s41419-026-09105-1,https://pubmed.ncbi.nlm.nih.gov/42443163/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,39558224,DAPK enhances DDX20 protein stability via suppression of TRIM25-mediated ubiquitination-based DDX20 degradation.,2024,10.1186/s12935-024-03567-z,https://pubmed.ncbi.nlm.nih.gov/39558224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,37894677,DDX20: A Multifunctional Complex Protein.,2023,10.3390/molecules28207198,https://pubmed.ncbi.nlm.nih.gov/37894677/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,38657611,DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice.,2024,10.1016/j.devcel.2024.04.002,https://pubmed.ncbi.nlm.nih.gov/38657611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,39021191,Envafolimab Inhibits the Growth of Gastric Cancer Cells with Low PD-L1 Expression through the DDX20/NF-κB/TNF-α Signaling Pathway.,2025,10.2174/0115680096314855240619181909,https://pubmed.ncbi.nlm.nih.gov/39021191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,36246406,"A Macrophage Differentiation-Mediated Gene: DDX20 as a Molecular Biomarker Encompassing the Tumor Microenvironment, Disease Staging, and Prognoses in Hepatocellular Carcinoma.",2022,10.1155/2022/9971776,https://pubmed.ncbi.nlm.nih.gov/36246406/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,38552910,DDX20 positively regulates the interferon pathway to inhibit viral infection.,2024,10.1016/j.antiviral.2024.105875,https://pubmed.ncbi.nlm.nih.gov/38552910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,37116198,An artificial neural network model to diagnose non-obstructive azoospermia based on RNA-binding protein-related genes.,2023,10.18632/aging.204674,https://pubmed.ncbi.nlm.nih.gov/37116198/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,31822699,"SMN complex member Gemin3 self-interacts and has a functional relationship with ALS-linked proteins TDP-43, FUS and Sod1.",2019,10.1038/s41598-019-53508-4,https://pubmed.ncbi.nlm.nih.gov/31822699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,37783676,WDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2.,2023,10.1038/s41389-023-00493-z,https://pubmed.ncbi.nlm.nih.gov/37783676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,34290392,"The combined detection of Amphiregulin, Cyclin A1 and DDX20/Gemin3 expression predicts aggressive forms of oral squamous cell carcinoma.",2021,10.1038/s41416-021-01491-x,https://pubmed.ncbi.nlm.nih.gov/34290392/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,38969288,Single nucleotide polymorphisms of GEMIN3 modify the risk of primary Sjögren's syndrome in female patients.,2025,10.1016/j.amjms.2024.07.001,https://pubmed.ncbi.nlm.nih.gov/38969288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,36619669,Survival motor neuron protein and neurite degeneration are regulated by Gemin3 in spinal muscular atrophy motoneurons.,2022,10.3389/fncel.2022.1054270,https://pubmed.ncbi.nlm.nih.gov/36619669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,29523774,The multiple lives of DEAD-box RNA helicase DP103/DDX20/Gemin3.,2018,10.1042/bst20180016,https://pubmed.ncbi.nlm.nih.gov/29523774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,36244220,Integration of RNAi and RNA-seq uncovers the regulation mechanism of DDX20 on vitellogenin expression in Scylla paramamosain.,2022,10.1016/j.cbd.2022.101028,https://pubmed.ncbi.nlm.nih.gov/36244220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,33005307,"Analysis of the expression, function, prognosis and co-expression genes of DDX20 in gastric cancer.",2020,10.1016/j.csbj.2020.09.002,https://pubmed.ncbi.nlm.nih.gov/33005307/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,36405016,Association of polymorphic variants in GEMIN genes with the risk of depression in a Polish population.,2022,10.7717/peerj.14317,https://pubmed.ncbi.nlm.nih.gov/36405016/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,36551880,Relationship between the Occurrence of Genetic Variants of Single Nucleotide Polymorphism in microRNA Processing Genes and the Risk of Developing Multiple Sclerosis.,2022,10.3390/biomedicines10123124,https://pubmed.ncbi.nlm.nih.gov/36551880/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,34578385,"Construction, Identification and Analysis of the Interaction Network of African Swine Fever Virus MGF360-9L with Host Proteins.",2021,10.3390/v13091804,https://pubmed.ncbi.nlm.nih.gov/34578385/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,32218991,A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation.,2020,10.1038/s41536-020-0089-0,https://pubmed.ncbi.nlm.nih.gov/32218991/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,25083991,DEAD-box helicase DP103 defines metastatic potential of human breast cancers.,2014,10.1172/jci73451,https://pubmed.ncbi.nlm.nih.gov/25083991/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,35154063,Global Phosphoproteomics Analysis of IBRS-2 Cells Infected With Senecavirus A.,2022,10.3389/fmicb.2022.832275,https://pubmed.ncbi.nlm.nih.gov/35154063/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,31455417,Integrating transcriptome-wide study and mRNA expression profiles yields novel insights into the biological mechanism of chondropathies.,2019,10.1186/s13075-019-1978-8,https://pubmed.ncbi.nlm.nih.gov/31455417/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,27388936,"Disruption of snRNP biogenesis factors Tgs1 and pICln induces phenotypes that mirror aspects of SMN-Gemins complex perturbation in Drosophila, providing new insights into spinal muscular atrophy.",2016,10.1016/j.nbd.2016.06.015,https://pubmed.ncbi.nlm.nih.gov/27388936/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,25709475,Single-nucleotide polymorphisms of microRNA processing machinery genes and risk of colorectal cancer.,2015,10.2147/ott.s78647,https://pubmed.ncbi.nlm.nih.gov/25709475/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,26203264,Single nucleotide polymorphisms of microRNA processing genes and outcome of non-Hodgkin's lymphoma.,2015,10.2147/ott.s86338,https://pubmed.ncbi.nlm.nih.gov/26203264/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,31068947,Scurfy Mice Develop Features of Connective Tissue Disease Overlap Syndrome and Mixed Connective Tissue Disease in the Absence of Regulatory T Cells.,2019,10.3389/fimmu.2019.00881,https://pubmed.ncbi.nlm.nih.gov/31068947/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,25784816,Single-nucleotide polymorphisms of microRNA processing machinery genes are associated with risk for gastric cancer.,2015,10.2147/ott.s79150,https://pubmed.ncbi.nlm.nih.gov/25784816/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,26098872,Genetic Interactions between the Members of the SMN-Gemins Complex in Drosophila.,2015,10.1371/journal.pone.0130974,https://pubmed.ncbi.nlm.nih.gov/26098872/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,27701053,MicroRNA-related polymorphisms and non-Hodgkin lymphoma susceptibility in the Multicenter AIDS Cohort Study.,2016,10.1016/j.canep.2016.09.007,https://pubmed.ncbi.nlm.nih.gov/27701053/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,23322153,Genetic variations in micro-RNA biogenesis genes and clinical outcomes in non-muscle-invasive bladder cancer.,2013,10.1093/carcin/bgt006,https://pubmed.ncbi.nlm.nih.gov/23322153/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX20,ENSG00000064703,Unsafe,28807014,Epigenetic reprogramming converts human Wharton's jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators.,2017,10.1186/s13287-017-0638-7,https://pubmed.ncbi.nlm.nih.gov/28807014/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,36834539,Single-Cell Transcriptomic Profiling of the Mouse Testicular Germ Cells Reveals Important Role of Phosphorylated GRTH/DDX25 in Round Spermatid Differentiation and Acrosome Biogenesis during Spermiogenesis.,2023,10.3390/ijms24043127,https://pubmed.ncbi.nlm.nih.gov/36834539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,36899892,miRNA Expression Profiles of Mouse Round Spermatids in GRTH/DDX25-Mediated Spermiogenesis: mRNA-miRNA Network Analysis.,2023,10.3390/cells12050756,https://pubmed.ncbi.nlm.nih.gov/36899892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,38668519,Decreased Ubiquitination and Acetylation of Histones 3 and 4 Are Associated with Obesity-Induced Disorders of Spermatogenesis in Mice.,2024,10.3390/toxics12040296,https://pubmed.ncbi.nlm.nih.gov/38668519/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,35203264,Chromatoid Bodies in the Regulation of Spermatogenesis: Novel Role of GRTH.,2022,10.3390/cells11040613,https://pubmed.ncbi.nlm.nih.gov/35203264/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,39331689,Loss-of-function variant in TDRD6 cause male infertility with severe oligo-astheno-teratozoospermia in human and mice.,2024,10.1111/jcmm.18580,https://pubmed.ncbi.nlm.nih.gov/39331689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,34601876,Blockade of GRTH/DDX25 Phosphorylation by Cyclic Peptides Provides an Avenue for Developing a Nonhormonal Male Contraceptive.,2021,10.1021/acs.jmedchem.1c01201,https://pubmed.ncbi.nlm.nih.gov/34601876/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,40713627,Cyclin dependent kinase 9 inhibitor induces transcription-replication conflicts and DNA damage accumulation in breast cancer.,2025,10.1186/s12935-025-03897-6,https://pubmed.ncbi.nlm.nih.gov/40713627/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,40239543,Putrescine modulates alternative splicing of gonadotropin hormone-releasing hormone (GnRH) through differential regulation of splicing factors.,2025,10.1016/j.bbrc.2025.151795,https://pubmed.ncbi.nlm.nih.gov/40239543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,31009948,Targeted knock-in mice with a human mutation in GRTH/DDX25 reveals the essential role of phosphorylated GRTH in spermatid development during spermatogenesis.,2019,10.1093/hmg/ddz079,https://pubmed.ncbi.nlm.nih.gov/31009948/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,33425888,Role of Phosphorylated Gonadotropin-Regulated Testicular RNA Helicase (GRTH/DDX25) in the Regulation of Germ Cell Specific mRNAs in Chromatoid Bodies During Spermatogenesis.,2020,10.3389/fcell.2020.580019,https://pubmed.ncbi.nlm.nih.gov/33425888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,31040297,Characterization of the Phosphorylation Site of GRTH/DDX25 and Protein Kinase A Binding Interface Provides Structural Basis for the Design of a Non-Hormonal Male Contraceptive.,2019,10.1038/s41598-019-42857-9,https://pubmed.ncbi.nlm.nih.gov/31040297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,31555207,"Gonadotropin Regulation Testicular RNA Helicase, Two Decades of Studies on Its Structure Function and Regulation From Its Discovery Opens a Window for Development of a Non-hormonal Oral Male Contraceptive.",2019,10.3389/fendo.2019.00576,https://pubmed.ncbi.nlm.nih.gov/31555207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,32478068,Linking Phospho-Gonadotropin Regulated Testicular RNA Helicase (GRTH/DDX25) to Histone Ubiquitination and Acetylation Essential for Spermatid Development During Spermiogenesis.,2020,10.3389/fcell.2020.00310,https://pubmed.ncbi.nlm.nih.gov/32478068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,37672513,Identification of candidate genes for developmental colour agnosia in a single unique family.,2023,10.1371/journal.pone.0290013,https://pubmed.ncbi.nlm.nih.gov/37672513/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,26484580,Germ Cell Nuclear Factor (GCNF/RTR) Regulates Transcription of Gonadotropin-Regulated Testicular RNA Helicase (GRTH/DDX25) in Testicular Germ Cells--The Androgen Connection.,2015,10.1210/me.2015-1198,https://pubmed.ncbi.nlm.nih.gov/26484580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,35172124,Whole-exome sequencing improves the diagnosis and care of men with non-obstructive azoospermia.,2022,10.1016/j.ajhg.2022.01.011,https://pubmed.ncbi.nlm.nih.gov/35172124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,28824886,DEAD-Box Helicase DDX25 Is a Negative Regulator of Type I Interferon Pathway and Facilitates RNA Virus Infection.,2017,10.3389/fcimb.2017.00356,https://pubmed.ncbi.nlm.nih.gov/28824886/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,22479328,Role of gonadotropin regulated testicular RNA helicase (GRTH/Ddx25) on polysomal associated mRNAs in mouse testis.,2012,10.1371/journal.pone.0032470,https://pubmed.ncbi.nlm.nih.gov/22479328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,23546600,A 5'-flanking region of gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) gene directs its cell-specific androgen-regulated gene expression in testicular germ cells.,2013,10.1210/en.2012-2230,https://pubmed.ncbi.nlm.nih.gov/23546600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,19875492,Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25): a multifunctional protein essential for spermatogenesis.,2010,10.2164/jandrol.109.008219,https://pubmed.ncbi.nlm.nih.gov/19875492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,32991915,The ubiquitination and acetylation of histones are associated with male reproductive disorders induced by chronic exposure to arsenite.,2020,10.1016/j.taap.2020.115253,https://pubmed.ncbi.nlm.nih.gov/32991915/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,31472347,Arsenic influences spermatogenesis by disorganizing the elongation of spermatids in adult male mice.,2020,10.1016/j.chemosphere.2019.124650,https://pubmed.ncbi.nlm.nih.gov/31472347/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,31330346,Fluoride-induced unrestored arrest during haploid period of spermatogenesis via the regulation of DDX25 in rats.,2019,10.1016/j.envpol.2019.06.107,https://pubmed.ncbi.nlm.nih.gov/31330346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,33456353,Integral Analysis of the RNA Binding Protein-associated Prognostic Model for Renal Cell Carcinoma.,2021,10.7150/ijms.50704,https://pubmed.ncbi.nlm.nih.gov/33456353/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,28181402,Allethrin toxicity causes reproductive dysfunction in male rats.,2017,10.1002/tox.22394,https://pubmed.ncbi.nlm.nih.gov/28181402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,8150787,Thyroid function and attention-deficit hyperactivity disorder.,1994,10.1097/00004583-199402000-00003,https://pubmed.ncbi.nlm.nih.gov/8150787/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,1991834,Screening of nineteen unrelated families with generalized resistance to thyroid hormone for known point mutations in the thyroid hormone receptor beta gene and the detection of a new mutation.,1991,10.1172/jci115023,https://pubmed.ncbi.nlm.nih.gov/1991834/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,9349583,Clinical and hormonal outcome after two years of triiodothyroacetic acid treatment in a child with thyroid hormone resistance.,1997,10.1089/thy.1997.7.775,https://pubmed.ncbi.nlm.nih.gov/9349583/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX25,ENSG00000109832,Unsafe,10608860,A novel gonadotropin-regulated testicular RNA helicase. A new member of the dead-box family.,1999,10.1074/jbc.274.53.37932,https://pubmed.ncbi.nlm.nih.gov/10608860/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,41157636,Comparative Transcriptomics Analyses Identify DDX43 as a Cellular Regulator Involved in Suppressing HSV-2 Replication.,2025,10.3390/v17101366,https://pubmed.ncbi.nlm.nih.gov/41157636/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,38807916,Effect of DNMT3A R882H Hot Spot Mutations on DDX43 Promoter Methylation in Acute Myeloid Leukemia.,2024,10.1155/2024/9625043,https://pubmed.ncbi.nlm.nih.gov/38807916/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,42303781,Omics signature of new-onset mild cognitive impairment and dementia in a population-based study.,2026,10.1038/s41598-026-58117-6,https://pubmed.ncbi.nlm.nih.gov/42303781/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,37200388,DDX43 mRNA expression and protein levels in relation to clinicopathological profile of breast cancer.,2023,10.1371/journal.pone.0284455,https://pubmed.ncbi.nlm.nih.gov/37200388/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,37120627,Single-cell RNA-seq uncovers dynamic processes orchestrated by RNA-binding protein DDX43 in chromatin remodeling during spermiogenesis.,2023,10.1038/s41467-023-38199-w,https://pubmed.ncbi.nlm.nih.gov/37120627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,39724251,Correction: DDX43 mRNA expression and protein levels in relation to clinicopathological profile of breast cancer.,2024,10.1371/journal.pone.0316591,https://pubmed.ncbi.nlm.nih.gov/39724251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,35257897,Structure-function analysis of DEAD-box helicase DDX43.,2022,10.1016/j.ymeth.2022.03.002,https://pubmed.ncbi.nlm.nih.gov/35257897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,34262856,A Novel HAGE/WT1-ImmunoBody® Vaccine Combination Enhances Anti-Tumour Responses When Compared to Either Vaccine Alone.,2021,10.3389/fonc.2021.636977,https://pubmed.ncbi.nlm.nih.gov/34262856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,42679008,Syndromic cholera diagnosis masks diverse causes of diarrhoeal disease in Burundi revealed by portable metagenomics.,2026,10.1371/journal.pntd.0014175,https://pubmed.ncbi.nlm.nih.gov/42679008/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,38235047,Herbal Combination 'HAGE-101912' Ameliorates Gastroesophageal Reflux Disease in Rats.,2023,10.4103/jpbs.jpbs_860_21,https://pubmed.ncbi.nlm.nih.gov/38235047/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,34990938,DDX43 recruits TRIF or IPS-1 as an adaptor and activates the IFN-β pathway in Nile tilapia (Oreochromis niloticus).,2022,10.1016/j.molimm.2021.12.020,https://pubmed.ncbi.nlm.nih.gov/34990938/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,36474801,Differential gene co-expression network analyses reveal novel molecules associated with transcriptional dysregulation of key biological processes in osteoarthritis knee cartilage.,2022,10.1016/j.ocarto.2022.100316,https://pubmed.ncbi.nlm.nih.gov/36474801/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,34105800,Helicase antigen (HAGE)-derived vaccines induce immunity to HAGE and ImmunoBody®-HAGE DNA vaccine delays the growth and metastasis of HAGE-expressing tumors in vivo.,2021,10.1111/imcb.12485,https://pubmed.ncbi.nlm.nih.gov/34105800/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,33555135,DEAD-box polypeptide 43 facilitates piRNA amplification by actively liberating RNA from Ago3-piRISC.,2021,10.15252/embr.202051313,https://pubmed.ncbi.nlm.nih.gov/33555135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,28468824,The DEAD-box protein DDX43 (HAGE) is a dual RNA-DNA helicase and has a K-homology domain required for full nucleic acid unwinding activity.,2017,10.1074/jbc.m117.774950,https://pubmed.ncbi.nlm.nih.gov/28468824/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,33199368,The KH domain facilitates the substrate specificity and unwinding processivity of DDX43 helicase.,2021,10.1074/jbc.ra120.015824,https://pubmed.ncbi.nlm.nih.gov/33199368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,29449695,Arresting of miR-186 and releasing of H19 by DDX43 facilitate tumorigenesis and CML progression.,2018,10.1038/s41388-018-0146-y,https://pubmed.ncbi.nlm.nih.gov/29449695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,38754565,Whole-transcriptome sequencing of phagocytes reveals a ceRNA network contributing to natural resistance to tuberculosis infection.,2024,10.1016/j.micpath.2024.106681,https://pubmed.ncbi.nlm.nih.gov/38754565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,38771739,"Evaluating Debio 1347 in Patients with FGFR Fusion-Positive Advanced Solid Tumors from the FUZE Multicenter, Open-Label, Phase II Basket Trial.",2024,10.1158/1078-0432.ccr-24-0012,https://pubmed.ncbi.nlm.nih.gov/38771739/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,31623828,DDX43 prefers single strand substrate and its full binding activity requires physical connection of all domains.,2019,10.1016/j.bbrc.2019.09.114,https://pubmed.ncbi.nlm.nih.gov/31623828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,37861461,"Xaluritamig, a STEAP1 × CD3 XmAb 2+1 Immune Therapy for Metastatic Castration-Resistant Prostate Cancer: Results from Dose Exploration in a First-in-Human Study.",2024,10.1158/2159-8290.cd-23-0964,https://pubmed.ncbi.nlm.nih.gov/37861461/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,37861452,"AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer.",2024,10.1158/2159-8290.cd-23-0984,https://pubmed.ncbi.nlm.nih.gov/37861452/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,33104183,Reply to Hage and Schuurmans.,2021,10.1093/cid/ciaa1633,https://pubmed.ncbi.nlm.nih.gov/33104183/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,37099501,"Unsupervised, frequent and remote: A novel platform for personalised digital phenotyping of long-term memory in humans.",2023,10.1371/journal.pone.0284220,https://pubmed.ncbi.nlm.nih.gov/37099501/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,38560188,Towards a new framework to assess agri-food value chains' sustainability - The case of chestnut value chain.,2024,10.1016/j.heliyon.2024.e27836,https://pubmed.ncbi.nlm.nih.gov/38560188/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,24755885,HAGE (DDX43) is a biomarker for poor prognosis and a predictor of chemotherapy response in breast cancer.,2014,10.1038/bjc.2014.168,https://pubmed.ncbi.nlm.nih.gov/24755885/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,27323861,Expression of tumor antigens on primary ovarian cancer cells compared to established ovarian cancer cell lines.,2016,10.18632/oncotarget.10028,https://pubmed.ncbi.nlm.nih.gov/27323861/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,26240276,"HAGE in Triple-Negative Breast Cancer Is a Novel Prognostic, Predictive, and Actionable Biomarker: A Transcriptomic and Protein Expression Analysis.",2016,10.1158/1078-0432.ccr-15-0610,https://pubmed.ncbi.nlm.nih.gov/26240276/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,20726502,A panel of cancer-testis genes exhibiting broad-spectrum expression in haematological malignancies.,2010,,https://pubmed.ncbi.nlm.nih.gov/20726502/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,35983428,Prostate Cancer Therapy Using Docetaxel and Formononetin Combination: Hyaluronic Acid and Epidermal Growth Factor Receptor Targeted Peptide Dual Ligands Modified Binary Nanoparticles to Facilitate the in vivo Anti-Tumor Activity.,2022,10.2147/dddt.s366622,https://pubmed.ncbi.nlm.nih.gov/35983428/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,19259670,Tumour antigen-targeted immunotherapy for chronic myeloid leukaemia: is it still viable?,2009,10.1007/s00262-009-0675-x,https://pubmed.ncbi.nlm.nih.gov/19259670/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,20058853,"HAGE, a cancer/testis antigen expressed at the protein level in a variety of cancers.",2010,,https://pubmed.ncbi.nlm.nih.gov/20058853/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,17487488,"HAGE, a cancer/testis antigen with potential for melanoma immunotherapy: identification of several MHC class I/II HAGE-derived immunogenic peptides.",2007,10.1007/s00262-007-0331-2,https://pubmed.ncbi.nlm.nih.gov/17487488/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX43,ENSG00000080007,Unsafe,10919659,Identification on a human sarcoma of two new genes with tumor-specific expression.,2000,,https://pubmed.ncbi.nlm.nih.gov/10919659/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,42723025,Bulk and single-cell transcriptome-based integrative analysis of an rRNA processing-related prognostic signature with functional validation of DDX47 in clear cell renal cell carcinoma.,2026,10.1186/s12885-026-16562-6,https://pubmed.ncbi.nlm.nih.gov/42723025/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,37553903,BIOINFORMATICS APPLICATIONS UNDER CONDITION CONTROL: HIGH DIAGNOSTIC VALUE OF DDX47 IN REAL MEDICAL SETTINGS.,2024,10.1097/shk.0000000000002199,https://pubmed.ncbi.nlm.nih.gov/37553903/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,35490652,DDX47 promotes cell proliferation and migration in lung adenocarcinoma.,2022,10.1016/j.prp.2022.153921,https://pubmed.ncbi.nlm.nih.gov/35490652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,35783639,A Novel Overall Survival Prediction Signature Based on Comprehensive Research in Prostate Cancer Bone Metastases.,2022,10.3389/fmed.2022.815541,https://pubmed.ncbi.nlm.nih.gov/35783639/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,35054771,DEAD-Box RNA Helicase DDX47 Maintains Midgut Homeostasis in Locusta migratoria.,2022,10.3390/ijms23020586,https://pubmed.ncbi.nlm.nih.gov/35054771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,36827184,"DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops.",2023,10.1016/j.celrep.2023.112148,https://pubmed.ncbi.nlm.nih.gov/36827184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,38328595,The Influence of Blue Light Exposure on Reconstructed 3-Dimensional Skin Model: Molecular Changes and Gene Expression Profile.,2024,10.1016/j.xjidi.2023.100252,https://pubmed.ncbi.nlm.nih.gov/38328595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,33710394,Exome sequencing reveals predominantly de novo variants in disorders with intellectual disability (ID) in the founder population of Finland.,2021,10.1007/s00439-021-02268-1,https://pubmed.ncbi.nlm.nih.gov/33710394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,34346026,Novel role of long non-coding RNAs in autoimmune cutaneous disease.,2022,10.1007/s12079-021-00639-x,https://pubmed.ncbi.nlm.nih.gov/34346026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,33456353,Integral Analysis of the RNA Binding Protein-associated Prognostic Model for Renal Cell Carcinoma.,2021,10.7150/ijms.50704,https://pubmed.ncbi.nlm.nih.gov/33456353/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,33488680,Transcriptome Analyses Identify an RNA Binding Protein Related Prognostic Model for Clear Cell Renal Cell Carcinoma.,2020,10.3389/fgene.2020.617872,https://pubmed.ncbi.nlm.nih.gov/33488680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,33982894,"Lupus Susceptibility Region Containing CDKN1B rs34330 Mechanistically Influences Expression and Function of Multiple Target Genes, Also Linked to Proliferation and Apoptosis.",2021,10.1002/art.41799,https://pubmed.ncbi.nlm.nih.gov/33982894/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,31889940,The plasma peptides of breast versus ovarian cancer.,2019,10.1186/s12014-019-9262-0,https://pubmed.ncbi.nlm.nih.gov/31889940/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,27334696,A genetic link between epigenetic repressor AS1-AS2 and a putative small subunit processome in leaf polarity establishment of Arabidopsis.,2016,10.1242/bio.019109,https://pubmed.ncbi.nlm.nih.gov/27334696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,20941364,Comparative structural analysis of human DEAD-box RNA helicases.,2010,10.1371/journal.pone.0012791,https://pubmed.ncbi.nlm.nih.gov/20941364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,26443847,Role of the small subunit processome in the maintenance of pluripotent stem cells.,2015,10.1101/gad.267112.115,https://pubmed.ncbi.nlm.nih.gov/26443847/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,16963496,NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47.,2006,10.1093/nar/gkl603,https://pubmed.ncbi.nlm.nih.gov/16963496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,25268383,Genome-wide association study for wool production traits in a Chinese Merino sheep population.,2014,10.1371/journal.pone.0107101,https://pubmed.ncbi.nlm.nih.gov/25268383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,19654405,The derivation of diagnostic markers of chronic myeloid leukemia progression from microarray data.,2009,10.1182/blood-2009-03-212969,https://pubmed.ncbi.nlm.nih.gov/19654405/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DDX47,ENSG00000213782,Unsafe,31256877,Paralog Studies Augment Gene Discovery: DDX and DHX Genes.,2019,10.1016/j.ajhg.2019.06.001,https://pubmed.ncbi.nlm.nih.gov/31256877/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB119,ENSG00000180483,Unsafe,36513070,β-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility.,2022,10.1016/j.xcrm.2022.100825,https://pubmed.ncbi.nlm.nih.gov/36513070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB119,ENSG00000180483,Unsafe,39359400,DEFB119 stratifies dysbiosis with distorted networks in the seminal microbiome associated with male infertility.,2024,10.1093/pnasnexus/pgae419,https://pubmed.ncbi.nlm.nih.gov/39359400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB119,ENSG00000180483,Unsafe,36414976,Defb19 regulates the migration of germ cell and is involved in male fertility.,2022,10.1186/s13578-022-00924-1,https://pubmed.ncbi.nlm.nih.gov/36414976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB119,ENSG00000180483,Unsafe,38745232,Single-cell and spatial transcriptomic investigation reveals the spatiotemporal specificity of the beta-defensin gene family during mouse sperm maturation.,2024,10.1186/s12964-024-01637-3,https://pubmed.ncbi.nlm.nih.gov/38745232/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB119,ENSG00000180483,Unsafe,36571327,In silico docking analysis of beta-defensin 20 against cation channel sperm-associated protein 1-4 to predict its role in the sperm maturation.,2023,10.4103/aja2022103,https://pubmed.ncbi.nlm.nih.gov/36571327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB119,ENSG00000180483,Unsafe,33060057,Mouse defensin beta 20 (Defb20) is expressed specifically in the caput region of the epididymis and regulated by androgen and testicular factors.,2020,10.1016/j.repbio.2020.09.003,https://pubmed.ncbi.nlm.nih.gov/33060057/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB119,ENSG00000180483,Unsafe,39933395,Identification of potential drug targets for four site-specific cancers by integrating human plasma proteome with genome.,2025,10.1016/j.jpba.2025.116731,https://pubmed.ncbi.nlm.nih.gov/39933395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB119,ENSG00000180483,Unsafe,38135080,Maternal urban particulate matter (SRM 1648a) exposure disrupted the cellular immune homeostasis during early life: The potential attribution of altered placental transcriptome profile.,2024,10.1016/j.scitotenv.2023.169432,https://pubmed.ncbi.nlm.nih.gov/38135080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB119,ENSG00000180483,Unsafe,32108034,The Search for Molecular Markers in a Gene-Orphan Case Study of a Pediatric Spinal Cord Pilocytic Astrocytoma.,2020,10.21873/cgp.20172,https://pubmed.ncbi.nlm.nih.gov/32108034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB119,ENSG00000180483,Unsafe,32030088,Comparative RNA-Seq Analysis of Differentially Expressed Genes in the Epididymides of Yak and Cattleyak.,2019,10.2174/1389202920666190809092819,https://pubmed.ncbi.nlm.nih.gov/32030088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB119,ENSG00000180483,Unsafe,38254476,"Genetic Diversity, Population Structure and Selection Signature in Begait Goats Revealed by Whole-Genome Sequencing.",2024,10.3390/ani14020307,https://pubmed.ncbi.nlm.nih.gov/38254476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB119,ENSG00000180483,Unsafe,24449502,Production and characterization of recombinant human beta-defensin DEFB120.,2014,10.1002/psc.2611,https://pubmed.ncbi.nlm.nih.gov/24449502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB119,ENSG00000180483,Unsafe,15772680,"Identification, characterization, and evolution of a primate beta-defensin gene cluster.",2005,10.1038/sj.gene.6364184,https://pubmed.ncbi.nlm.nih.gov/15772680/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEFB119,ENSG00000180483,Unsafe,28379507,Impact of male fertility status on the transcriptome of the bovine epididymis.,2017,10.1093/molehr/gax019,https://pubmed.ncbi.nlm.nih.gov/28379507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,41851532,"TCF7L2/DEPDC1 axis contributes to tumor progression by promoting cell proliferation, aerobic glycolysis, and immunosuppression in pancreatic cancer.",2026,10.1007/s10238-026-02109-3,https://pubmed.ncbi.nlm.nih.gov/41851532/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,42500733,Delafloxacin suppresses DEPDC1 expression and induces G2/M arrest in non-small cell lung cancer cells: A drug repurposing study.,2026,10.1002/smo2.70050,https://pubmed.ncbi.nlm.nih.gov/42500733/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,41057958,DEP domain containing 1: a potential oncogenic driver.,2025,10.1186/s40659-025-00643-0,https://pubmed.ncbi.nlm.nih.gov/41057958/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,42222424,Methylation-regulated miR-374a-5p and miR-374b-5p suppress glycolysis and malignant progression of head and neck squamous cell carcinoma by targeting DEPDC1.,2026,10.3389/fonc.2026.1816226,https://pubmed.ncbi.nlm.nih.gov/42222424/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,42444536,Revealing the Correlation Between NLRP3 Inflammasome-Related Genes and Intervertebral Disc Degeneration Based Multiomic Analysis and Experimental Validation.,2026,10.1155/mi/1534745,https://pubmed.ncbi.nlm.nih.gov/42444536/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,41003831,LncRNA DEPDC1-AS1 drives the progression of endometrial carcinoma by regulating miR-508-3p.,2025,10.1007/s12672-025-03417-y,https://pubmed.ncbi.nlm.nih.gov/41003831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,40600015,DEPDC1 facilitated malignant phenotypes and disease progression of liposarcoma by modulating KIF20A.,2025,10.3389/fendo.2025.1591390,https://pubmed.ncbi.nlm.nih.gov/40600015/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,38765113,DEP domain containing 1 as a biomarker for poor prognosis in lung adenocarcinoma.,2024,10.1016/j.heliyon.2024.e30642,https://pubmed.ncbi.nlm.nih.gov/38765113/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,42861757,Identification of Key Genes and Construction of miRNA-mRNA Regulatory Networks Associated with Glioma Grade by Bioinformatics Analysis.,2026,10.2174/0109298673468802260903111711,https://pubmed.ncbi.nlm.nih.gov/42861757/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,40247989,DEP domain‑containing 1 is a prognostic biomarker associated with the cell cycle in gliomas.,2025,10.3892/ol.2025.15022,https://pubmed.ncbi.nlm.nih.gov/40247989/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,40018408,The human 18S rRNA m6A methyltransferase METTL5 promotes tumorigenesis via DEPDC1 in lung squamous cell carcinoma.,2025,10.3389/fonc.2025.1522157,https://pubmed.ncbi.nlm.nih.gov/40018408/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,39296974,Roles of DEPDC1 in various types of cancer (Review).,2024,10.3892/ol.2024.14651,https://pubmed.ncbi.nlm.nih.gov/39296974/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,39004911,FOXM1/DEPDC1 feedback loop promotes hepatocarcinogenesis and represents promising targets for cancer therapy.,2024,10.1111/cas.16273,https://pubmed.ncbi.nlm.nih.gov/39004911/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,38564630,Comprehensive analysis and validation reveal DEPDC1 as a potential diagnostic biomarker associated with tumor immunity in non-small-cell lung cancer.,2024,10.1371/journal.pone.0294227,https://pubmed.ncbi.nlm.nih.gov/38564630/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,40263321,Retraction Note: Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression.,2025,10.1038/s41419-025-07669-y,https://pubmed.ncbi.nlm.nih.gov/40263321/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,39992478,YY1-mediated DUXAP8 facilitates HCC progression via modulating DEPDC1 expression.,2025,10.1007/s10238-025-01572-8,https://pubmed.ncbi.nlm.nih.gov/39992478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,39068164,DEPDC1 as a metabolic target regulates glycolysis in renal cell carcinoma through AKT/mTOR/HIF1α pathway.,2024,10.1038/s41419-024-06913-1,https://pubmed.ncbi.nlm.nih.gov/39068164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,40179432,Biomarkers and potential function analysis of triple-negative breast cancer screening based on bioinformatics.,2025,10.1177/18758592241308738,https://pubmed.ncbi.nlm.nih.gov/40179432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,41461910,p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism.,2026,10.1038/s41588-025-02446-1,https://pubmed.ncbi.nlm.nih.gov/41461910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,40093327,Identification of glycolysis-related gene signatures for prognosis and therapeutic targeting in idiopathic pulmonary fibrosis.,2025,10.3389/fphar.2025.1486357,https://pubmed.ncbi.nlm.nih.gov/40093327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,36660720,Pan-cancer analysis of DEPDC1 as a candidate prognostic biomarker and associated with immune infiltration.,2022,10.21037/atm-22-5598,https://pubmed.ncbi.nlm.nih.gov/36660720/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,39995658,A prognostic signature of Glutathione metabolism-associated long non-coding RNAs for lung adenocarcinoma with immune microenvironment insights.,2025,10.3389/fimmu.2025.1477437,https://pubmed.ncbi.nlm.nih.gov/39995658/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,34268303,Artemisia argyi Essential Oil Inhibits Hepatocellular Carcinoma Metastasis via Suppression of DEPDC1 Dependent Wnt/β-Catenin Signaling Pathway.,2021,10.3389/fcell.2021.664791,https://pubmed.ncbi.nlm.nih.gov/34268303/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,29971464,Immunotherapy with cancer peptides in combination with intravesical bacillus Calmette-Guerin for patients with non-muscle invasive bladder cancer.,2018,10.1007/s00262-018-2197-x,https://pubmed.ncbi.nlm.nih.gov/29971464/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,36479633,DEPDC1 as a crucial factor in the progression of human osteosarcoma.,2023,10.1002/cam4.5340,https://pubmed.ncbi.nlm.nih.gov/36479633/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,36768316,Glycolysis-Related Gene Analyses Indicate That DEPDC1 Promotes the Malignant Progression of Oral Squamous Cell Carcinoma via the WNT/β-Catenin Signaling Pathway.,2023,10.3390/ijms24031992,https://pubmed.ncbi.nlm.nih.gov/36768316/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,38993370,A Phase 2 Study of S-588410 Maintenance Monotherapy for Platinum-Treated Advanced or Metastatic Urothelial Carcinoma.,2022,10.3233/blc-211592,https://pubmed.ncbi.nlm.nih.gov/38993370/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,36072787,FOXM1 is regulated by DEPDC1 to facilitate development and metastasis of oral squamous cell carcinoma.,2022,10.3389/fonc.2022.815998,https://pubmed.ncbi.nlm.nih.gov/36072787/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,39922815,Molecular characterization of pregnancy-associated breast cancer and insights on timing from GEICAM-EMBARCAM study.,2025,10.1038/s41523-025-00718-x,https://pubmed.ncbi.nlm.nih.gov/39922815/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1,ENSG00000024526,Unsafe,17452976,Involvement of upregulation of DEPDC1 (DEP domain containing 1) in bladder carcinogenesis.,2007,10.1038/sj.onc.1210466,https://pubmed.ncbi.nlm.nih.gov/17452976/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,41402613,Transcription Activation of DEPDC1B Upon EBF1 Loss Contributes to Cell Cycle Progression and Epithelial-Mesenchymal Transition in Colon Adenocarcinoma.,2026,10.1007/s10528-025-11307-9,https://pubmed.ncbi.nlm.nih.gov/41402613/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,42589442,MicroRNA Signatures of Fulvestrant-Treated Luminal Breast Cancer Cells: Identification of Therapeutic Targets Regulated by &lt;i&gt;miR-374b-5p&lt;/i&gt;.,2026,10.3390/ijms27156787,https://pubmed.ncbi.nlm.nih.gov/42589442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,38717641,XTP8 Promotes Ovarian Cancer Progression by Activating AKT/AMPK/mTOR Pathway to Regulate EMT.,2024,10.1007/s12013-024-01246-4,https://pubmed.ncbi.nlm.nih.gov/38717641/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,39087856,DEPDC1B: A novel tumor suppressor gene associated with immune infiltration in colon adenocarcinoma.,2024,10.1002/cam4.70043,https://pubmed.ncbi.nlm.nih.gov/39087856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,41217566,Single-cell multi-omics of ribosome biogenesis-related genes reveals immune microenvironment in psoriasis and constructs a diagnostic model.,2025,10.1007/s10238-025-01916-4,https://pubmed.ncbi.nlm.nih.gov/41217566/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,37642235,DEPDC1B-mediated USP5 deubiquitination of β-catenin promotes breast cancer metastasis by activating the wnt/β-catenin pathway.,2023,10.1152/ajpcell.00249.2023,https://pubmed.ncbi.nlm.nih.gov/37642235/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,37191806,Illuminating DEPDC1B in Multi-pronged Regulation of Tumor Progression.,2023,10.1007/978-1-0716-3163-8_21,https://pubmed.ncbi.nlm.nih.gov/37191806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,37979396,DEPDC1B enhances malignant phenotypes of multiple myeloma through upregulating CCNB1 and inhibiting p53 signaling pathway.,2024,10.1016/j.tice.2023.102263,https://pubmed.ncbi.nlm.nih.gov/37979396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,41184589,Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors.,2025,10.1038/s44318-025-00613-y,https://pubmed.ncbi.nlm.nih.gov/41184589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,39844908,"DEPDC1B, CDCA2, APOBEC3B, and TYMS are potential hub genes and therapeutic targets for diagnosing dialysis patients with heart failure.",2024,10.3389/fcvm.2024.1442238,https://pubmed.ncbi.nlm.nih.gov/39844908/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,36016512,DEPDC1B promotes colorectal cancer via facilitating cell proliferation and migration while inhibiting apoptosis.,2023,10.1080/15384101.2022.2110439,https://pubmed.ncbi.nlm.nih.gov/36016512/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,38614125,ZNF146 regulates cell cycle progression via TFDP1 and DEPDC1B in ovarian cancer cells.,2024,10.1530/rep-23-0484,https://pubmed.ncbi.nlm.nih.gov/38614125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,38940035,DEPDC1B is a Novel Direct Target of B-Myb and Contributes to Malignant Progression and Immune Infiltration in Lung Adenocarcinoma.,2024,10.31083/j.fbl2906204,https://pubmed.ncbi.nlm.nih.gov/38940035/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,37056386,Role of DEP domain-containing protein 1B (DEPDC1B) in epithelial ovarian cancer.,2023,10.7150/jca.78423,https://pubmed.ncbi.nlm.nih.gov/37056386/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,37742812,"Platycodin D inhibits glioblastoma cell proliferation, migration, and invasion by regulating DEPDC1B-mediated epithelial-to-mesenchymal transition.",2023,10.1016/j.ejphar.2023.176074,https://pubmed.ncbi.nlm.nih.gov/37742812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,36568241,DEPDC1B promotes development of cholangiocarcinoma through enhancing the stability of CDK1 and regulating malignant phenotypes.,2022,10.3389/fonc.2022.842205,https://pubmed.ncbi.nlm.nih.gov/36568241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,38382096,The high expression of TOP2A and MELK induces the occurrence of psoriasis.,2024,10.18632/aging.205519,https://pubmed.ncbi.nlm.nih.gov/38382096/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,35706026,DEPDC1B collaborates with GABRD to regulate ESCC progression.,2022,10.1186/s12935-022-02593-z,https://pubmed.ncbi.nlm.nih.gov/35706026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,37203403,"DEPDC1B is involved in the proliferation, metastasis, cell cycle arrest and apoptosis of colon cancer cells by regulating NUP37.",2023,10.3892/mmr.2023.13013,https://pubmed.ncbi.nlm.nih.gov/37203403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,35095994,Identification and Validation of DEPDC1B as an Independent Early Diagnostic and Prognostic Biomarker in Liver Hepatocellular Carcinoma.,2021,10.3389/fgene.2021.681809,https://pubmed.ncbi.nlm.nih.gov/35095994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,35912402,High Expression of DEPDC1B Predicts Poor Prognosis in Lung Adenocarcinoma.,2022,10.2147/jir.s369219,https://pubmed.ncbi.nlm.nih.gov/35912402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,34983303,DEP domain containing 1B (DEPDC1B) exerts the tumor promoter in hepatocellular carcinoma through activating p53 signaling pathway via kinesin family member 23 (KIF23).,2022,10.1080/21655979.2021.2017629,https://pubmed.ncbi.nlm.nih.gov/34983303/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,39287711,Characteristic changes in the mRNA expression profile of plasma exosomes from patients with MPO-ANCA-associated vasculitis and its possible correlations with pathogenesis.,2024,10.1007/s10238-024-01457-2,https://pubmed.ncbi.nlm.nih.gov/39287711/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,32147621,Establishment of rat anti-canine DEP domain containing 1B (DEPDC1B) monoclonal antibodies.,2020,10.1292/jvms.19-0667,https://pubmed.ncbi.nlm.nih.gov/32147621/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,36785674,Identification of a Five Immune Term Signature for Prognosis and Therapy Options (Immunotherapy versus Targeted Therapy) for Patients with Hepatocellular Carcinoma.,2023,10.1155/2023/8958962,https://pubmed.ncbi.nlm.nih.gov/36785674/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,32934714,DEPDC1B promotes migration and invasion in pancreatic ductal adenocarcinoma by activating the Akt/GSK3β/Snail pathway.,2020,10.3892/ol.2020.12009,https://pubmed.ncbi.nlm.nih.gov/32934714/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,36530971,Identification of a novel gene signature of lung adenocarcinoma based on epidermal growth factor receptor-tyrosine kinase inhibitor resistance.,2022,10.3389/fonc.2022.1008283,https://pubmed.ncbi.nlm.nih.gov/36530971/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,39853911,Potential Biomarkers for Predicting the Risk of Developing Into Long COVID After COVID-19 Infection.,2025,10.1002/iid3.70137,https://pubmed.ncbi.nlm.nih.gov/39853911/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,32110046,DEP Domain-Containing Protein 1B (DEPDC1B) Promotes Migration and Invasion in Pancreatic Cancer Through the Rac1/PAK1-LIMK1-Cofilin1 Signaling Pathway.,2020,10.2147/ott.s229055,https://pubmed.ncbi.nlm.nih.gov/32110046/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,29163701,High levels of DEPDC1B predict shorter biochemical recurrence-free survival of patients with prostate cancer.,2017,10.3892/ol.2017.7027,https://pubmed.ncbi.nlm.nih.gov/29163701/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC1B,ENSG00000035499,Unsafe,33978371,Identification of Key Genes and Pathways Associated with Hepatosplenic T-Cell Lymphoma (HSTCL) by Bioinformatics Analysis.,2021,10.7754/clin.lab.2020.201018,https://pubmed.ncbi.nlm.nih.gov/33978371/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC7,ENSG00000121690,Unsafe,42449364,DEPDC7 couples homologous chromosome segregation to asymmetric cytokinesis through recruiting ARP2/3 complex in oocyte meiosis.,2026,10.1186/s12964-026-03068-8,https://pubmed.ncbi.nlm.nih.gov/42449364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC7,ENSG00000121690,Unsafe,42332067,The mechanisms of DEPDC7-mediated actin cap establishment and meiosis progression in oocytes.,2026,10.1038/s44319-026-00842-0,https://pubmed.ncbi.nlm.nih.gov/42332067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC7,ENSG00000121690,Unsafe,41930189,DEPDC7 as a potential tumor suppressor in hepatocellular carcinoma: preliminary evidence for targeting the JAK1/STAT3 axis.,2026,10.3389/fonc.2026.1719731,https://pubmed.ncbi.nlm.nih.gov/41930189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC7,ENSG00000121690,Unsafe,39548390,Investigating the diagnostic and prognostic significance of genes related to fatty acid metabolism in hepatocellular carcinoma.,2024,10.1186/s12876-024-03495-2,https://pubmed.ncbi.nlm.nih.gov/39548390/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC7,ENSG00000121690,Unsafe,37672513,Identification of candidate genes for developmental colour agnosia in a single unique family.,2023,10.1371/journal.pone.0290013,https://pubmed.ncbi.nlm.nih.gov/37672513/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC7,ENSG00000121690,Unsafe,29344171,"DEPDC7 inhibits cell proliferation, migration and invasion in hepatoma cells.",2017,10.3892/ol.2017.7128,https://pubmed.ncbi.nlm.nih.gov/29344171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC7,ENSG00000121690,Unsafe,27016254,Construction and Identification of the RNAi Recombinant Lentiviral Vector Targeting Human DEPDC7 Gene.,2017,10.1007/s12539-016-0162-y,https://pubmed.ncbi.nlm.nih.gov/27016254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC7,ENSG00000121690,Unsafe,25541973,"The Dishevelled, EGL-10 and pleckstrin (DEP) domain-containing protein DEPDC7 binds to CARMA2 and CARMA3 proteins, and regulates NF-κB activation.",2014,10.1371/journal.pone.0116062,https://pubmed.ncbi.nlm.nih.gov/25541973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC7,ENSG00000121690,Unsafe,25952135,Further evidence of DEPDC7 DNA hypomethylation in depression: A study in adult twins.,2015,10.1016/j.eurpsy.2015.04.001,https://pubmed.ncbi.nlm.nih.gov/25952135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC7,ENSG00000121690,Unsafe,32636717,The plasma peptides of sepsis.,2020,10.1186/s12014-020-09288-5,https://pubmed.ncbi.nlm.nih.gov/32636717/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEPDC7,ENSG00000121690,Unsafe,10568747,A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1.,1999,10.1101/gr.9.11.1074,https://pubmed.ncbi.nlm.nih.gov/10568747/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,41820353,DEUP1 functions as a scaffold for basal foot integrity and planar polarity in multiciliated cells.,2026,10.1038/s41467-026-70661-3,https://pubmed.ncbi.nlm.nih.gov/41820353/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,41413096,Zmynd10 drives centriole biogenesis and multiciliogenesis through the transcriptional regulation of E2f4.,2025,10.1038/s41598-025-27956-0,https://pubmed.ncbi.nlm.nih.gov/41413096/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,38052490,Deup1 Expression Interferes with Multiciliated Differentiation.,2023,10.14348/molcells.2023.0149,https://pubmed.ncbi.nlm.nih.gov/38052490/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,42371315,BMP/Ventx1.1 axis modulates the multiciliogenesis in the early Xenopus epidermis.,2026,10.1007/s13258-026-01777-5,https://pubmed.ncbi.nlm.nih.gov/42371315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,33658185,Biophysical and biochemical properties of Deup1 self-assemblies: a potential driver for deuterosome formation during multiciliogenesis.,2021,10.1242/bio.056432,https://pubmed.ncbi.nlm.nih.gov/33658185/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,34260288,"E2F4's cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6.",2021,10.1091/mbc.e21-01-0039,https://pubmed.ncbi.nlm.nih.gov/34260288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,31423198,Clinical significance of aberrant DEUP1 promoter methylation in hepatocellular carcinoma.,2019,10.3892/ol.2019.10421,https://pubmed.ncbi.nlm.nih.gov/31423198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,31611958,Generation and identification of a thyroid cancer cell line with stable expression of CCDC67 and luciferase reporter genes.,2019,10.3892/ol.2019.10839,https://pubmed.ncbi.nlm.nih.gov/31611958/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,31558434,Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures.,2019,10.1242/dev.177428,https://pubmed.ncbi.nlm.nih.gov/31558434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,34417538,Detection of fusion gene transcripts in the blood samples of prostate cancer patients.,2021,10.1038/s41598-021-96528-9,https://pubmed.ncbi.nlm.nih.gov/34417538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,26716505,Characterization of the novel tumor-suppressor gene CCDC67 in papillary thyroid carcinoma.,2016,10.18632/oncotarget.6709,https://pubmed.ncbi.nlm.nih.gov/26716505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,31081096,"MiR-96-5p promotes the proliferation, invasion and metastasis of papillary thyroid carcinoma through down-regulating CCDC67.",2019,10.26355/eurrev_201904_17706,https://pubmed.ncbi.nlm.nih.gov/31081096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,36323871,Estimates of genomic heritability and genome-wide association studies for blood parameters in Akkaraman sheep.,2022,10.1038/s41598-022-22966-8,https://pubmed.ncbi.nlm.nih.gov/36323871/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,33285087,A role for Cep70 in centriole amplification in multiciliated cells.,2021,10.1016/j.ydbio.2020.11.011,https://pubmed.ncbi.nlm.nih.gov/33285087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,30705370,Identification of recurrent fusion genes across multiple cancer types.,2019,10.1038/s41598-019-38550-6,https://pubmed.ncbi.nlm.nih.gov/30705370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,25399985,[Expression of CCDC67 mRNA and its role in patients with papillary thyroid carcinoma].,2014,,https://pubmed.ncbi.nlm.nih.gov/25399985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,22610074,Epigenetic alteration of CCDC67 and its tumor suppressor function in gastric cancer.,2012,10.1093/carcin/bgs178,https://pubmed.ncbi.nlm.nih.gov/22610074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,28459452,Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene.,2017,10.1038/nbt.3843,https://pubmed.ncbi.nlm.nih.gov/28459452/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,24613305,Proximity interactions among centrosome components identify regulators of centriole duplication.,2014,10.1016/j.cub.2014.01.067,https://pubmed.ncbi.nlm.nih.gov/24613305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,25238935,Novel fusion transcripts associate with progressive prostate cancer.,2014,10.1016/j.ajpath.2014.06.025,https://pubmed.ncbi.nlm.nih.gov/25238935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,35947357,Genome-wide association study biomarkers in T-cell mediated rejection: selective effect according to the Banff classification.,2023,10.1007/s40620-022-01419-5,https://pubmed.ncbi.nlm.nih.gov/35947357/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,27272414,Genome-Wide Association Study of Acute Renal Graft Rejection.,2017,10.1111/ajt.13912,https://pubmed.ncbi.nlm.nih.gov/27272414/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DEUP1,ENSG00000165325,Unsafe,28355295,Risk prediction of pulmonary tuberculosis using genetic and conventional risk factors in adult Korean population.,2017,10.1371/journal.pone.0174642,https://pubmed.ncbi.nlm.nih.gov/28355295/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,40921406,Diacylglycerol kinase gene Dgkh deficiency disrupts testicular lipid balance in male mice without affecting fertility.,2025,10.1530/rep-25-0017,https://pubmed.ncbi.nlm.nih.gov/40921406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,42163799,Diacylglycerol Kinase Eta as a Novel Target in NRAS Mutant Melanoma.,2026,10.1111/pcmr.70090,https://pubmed.ncbi.nlm.nih.gov/42163799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,42541249,Genetic Susceptibility to Nephrolithiasis: A Genome-Phenome Approach with Polygenic Risk Score Analysis.,2026,10.1159/000553005,https://pubmed.ncbi.nlm.nih.gov/42541249/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,40600984,High glucose mediates diabetic peripheral neuropathy by inducing Schwann cells apoptosis through the Dgkh/PKC-α signaling pathway.,2025,10.1007/s00592-025-02553-9,https://pubmed.ncbi.nlm.nih.gov/40600984/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,41323031,DGKH-PA-mTOR: A pharmacologically druggable metabolic axis underpinning tyrosine-kinase-inhibitor resistance in hepatocellular carcinoma.,2025,10.1016/j.iliver.2025.100198,https://pubmed.ncbi.nlm.nih.gov/41323031/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,42459798,Lentinan alleviates metabolic dysfunction implicating &lt;i&gt;Parabacteroides goldsteinii&lt;/i&gt;-enriched gut microbiota and hepatic lipid metabolism reprogramming through gut-liver axis-associated mechanisms.,2026,10.3389/fnut.2026.1841358,https://pubmed.ncbi.nlm.nih.gov/42459798/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,39663958,DGKH-mediated phosphatidic acid oncometabolism as a driver of self-renewal and therapy resistance in HCC.,2025,10.1097/hep.0000000000001158,https://pubmed.ncbi.nlm.nih.gov/39663958/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,37509516,Role of Diacylglycerol Kinases in Acute Myeloid Leukemia.,2023,10.3390/biomedicines11071877,https://pubmed.ncbi.nlm.nih.gov/37509516/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,37385994,High glucose induces tau hyperphosphorylation in hippocampal neurons via inhibition of ALKBH5-mediated Dgkh m6A demethylation: a potential mechanism for diabetic cognitive dysfunction.,2023,10.1038/s41419-023-05909-7,https://pubmed.ncbi.nlm.nih.gov/37385994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,41007894,"Daidzein Changes Production Performance, Meat Quality, and Transcriptome of Muscle in Heat-Stressed Jinjiang Cattle.",2025,10.3390/ani15182650,https://pubmed.ncbi.nlm.nih.gov/41007894/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,39943096,Blood-Based Whole-Genome Methylation Analysis of Yili Horses Pre- and Post-Racing.,2025,10.3390/ani15030326,https://pubmed.ncbi.nlm.nih.gov/39943096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,39509359,Genetic characterization and selection of litter size traits of Guizhou Black goat and Meigu goat.,2024,10.1371/journal.pone.0313297,https://pubmed.ncbi.nlm.nih.gov/39509359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,39634238,Investigation of Genetic Changes in Three Families with Bipolar Disease.,2024,10.1159/000539115,https://pubmed.ncbi.nlm.nih.gov/39634238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,39447331,Integrative multiomics analysis identifies key genes regulating intramuscular fat deposition during development.,2024,10.1016/j.psj.2024.104404,https://pubmed.ncbi.nlm.nih.gov/39447331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,39725721,High-resolution DNA methylation changes reveal biomarkers of heart failure with preserved ejection fraction versus reduced ejection fraction.,2025,10.1007/s00395-024-01093-7,https://pubmed.ncbi.nlm.nih.gov/39725721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,37542675,Molecular signature of excessive female aggression: study of stressed mice with genetic inactivation of neuronal serotonin synthesis.,2023,10.1007/s00702-023-02677-8,https://pubmed.ncbi.nlm.nih.gov/37542675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,36973590,"Coordinated modification in expression levels of HSPA1A/B, DGKH, and NOTCH2 in Parkinson's patients' blood and substantia nigra as a diagnostic sign: the transcriptomes' relationship.",2023,10.1007/s10072-023-06738-4,https://pubmed.ncbi.nlm.nih.gov/36973590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,38703760,Gut-brain bidirectional determination in regulating the residual feed intake of small-sized meat ducks.,2024,10.1016/j.psj.2024.103778,https://pubmed.ncbi.nlm.nih.gov/38703760/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,35909651,Recommendation of the German Society of Hospital Hygiene (DGKH): Prevention of COVID-19 by virucidal gargling and virucidal nasal spray - updated version April 2022.,2022,10.3205/dgkh000416,https://pubmed.ncbi.nlm.nih.gov/35909651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,35627254,Genetic Variants Associated with Neuropeptide Y Autoantibody Levels in Newly Diagnosed Individuals with Type 1 Diabetes.,2022,10.3390/genes13050869,https://pubmed.ncbi.nlm.nih.gov/35627254/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,38754473,A 10-Gene Signature to Predict the Prognosis of Early-Stage Triple-Negative Breast Cancer.,2024,10.4143/crt.2024.100,https://pubmed.ncbi.nlm.nih.gov/38754473/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,36482994,Machine learning-based metabolism-related genes signature and immune infiltration landscape in diabetic nephropathy.,2022,10.3389/fendo.2022.1026938,https://pubmed.ncbi.nlm.nih.gov/36482994/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,32047719,"Air quality in the operating room: Surgical site infections, HVAC systems and discipline - position paper of the German Society of Hospital Hygiene (DGKH).",2019,10.3205/dgkh000335,https://pubmed.ncbi.nlm.nih.gov/32047719/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,26120503,Beneficial effect of phosphatidylcholine supplementation in alleviation of hypomania and insomnia in a Chinese bipolar hypomanic boy and a possible explanation to the effect at the genetic level.,2015,10.1186/s40064-015-1002-y,https://pubmed.ncbi.nlm.nih.gov/26120503/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,26958457,"Hygiene guideline for the planning, installation, and operation of ventilation and air-conditioning systems in health-care settings - Guideline of the German Society for Hospital Hygiene (DGKH).",2016,10.3205/dgkh000263,https://pubmed.ncbi.nlm.nih.gov/26958457/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,32722439,Comparative Transcriptomic Analysis of the Pituitary Gland between Cattle Breeds Differing in Growth: Yunling Cattle and Leiqiong Cattle.,2020,10.3390/ani10081271,https://pubmed.ncbi.nlm.nih.gov/32722439/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,28972016,Philadelphia chromosome-like acute lymphoblastic leukemia.,2017,10.1182/blood-2017-06-743252,https://pubmed.ncbi.nlm.nih.gov/28972016/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,20941333,Infection prevention during anaesthesia ventilation by the use of breathing system filters (BSF): Joint recommendation by German Society of Hospital Hygiene (DGKH) and German Society for Anaesthesiology and Intensive Care (DGAI).,2010,10.3205/dgkh000156,https://pubmed.ncbi.nlm.nih.gov/20941333/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,20204102,Implementing the MRSA recommendations made by the Commission for Hospital Hygiene and Infection Prevention (KRINKO) of 1999 - current considerations by the DGKH Management Board.,2009,10.3205/dgkh000127,https://pubmed.ncbi.nlm.nih.gov/20204102/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,28804700,"Abridged version of the AWMF guideline for the medical clinical diagnostics of indoor mould exposure: S2K Guideline of the German Society of Hygiene, Environmental Medicine and Preventive Medicine (GHUP) in collaboration with the German Association of Allergists (AeDA), the German Society of Dermatology (DDG), the German Society for Allergology and Clinical Immunology (DGAKI), the German Society for Occupational and Environmental Medicine (DGAUM), the German Society for Hospital Hygiene (DGKH), the German Society for Pneumology and Respiratory Medicine (DGP), the German Mycological Society (DMykG), the Society for Pediatric Allergology and Environmental Medicine (GPA), the German Federal Association of Pediatric Pneumology (BAPP), and the Austrian Society for Medical Mycology (ÖGMM).",2017,10.1007/s40629-017-0013-3,https://pubmed.ncbi.nlm.nih.gov/28804700/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,21305782,[Reuse of injection needles of insulin pens and disposable insulin needles and skin disinfection before subcutaneous insulin injection. Consensus report of the German Society of Hospital Hygiene].,2011,,https://pubmed.ncbi.nlm.nih.gov/21305782/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,21127827,[Prevention of infections under anesthetic breathing with breathing filters: concerted recommendations of the Deutsche Gesellschaft für Krankenhaushygiene e.V. (DGKH) and the Deutsche Gesellschaft für Anästhesiologie und Intensivmedizin e.V. (DGAI)].,2010,10.1007/s00101-010-1818-3,https://pubmed.ncbi.nlm.nih.gov/21127827/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,24068962,Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.,2013,10.1371/journal.pgen.1003796,https://pubmed.ncbi.nlm.nih.gov/24068962/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DGKH,ENSG00000102780,Unsafe,12810723,Identification and characterization of two splice variants of human diacylglycerol kinase eta.,2003,10.1074/jbc.m301542200,https://pubmed.ncbi.nlm.nih.gov/12810723/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42371991,Desert Hedgehog mediates stem Leydig cell differentiation through Ptch2/Gli1/Sf1 signaling axis.,2026,10.7554/elife.109979,https://pubmed.ncbi.nlm.nih.gov/42371991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42512296,Development of a Cre-Inducible Rabl6a Transgenic Mouse Model That Enhances Sarcoma Growth In Vivo.,2026,10.3390/cancers18142230,https://pubmed.ncbi.nlm.nih.gov/42512296/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,41514699,Quantitative Postnatal Maturation of the Feline Testis from 6 to 36 Months: A Stereological and DHH Immunomorphological Analysis.,2025,10.3390/ani16010010,https://pubmed.ncbi.nlm.nih.gov/41514699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42782976,Oral Health in Deaf and Hard-of-Hearing Individuals: Addressing Widespread Global Health Barriers Through Emerging Digital Technologies-A Comprehensive Review.,2026,10.3390/dj14090589,https://pubmed.ncbi.nlm.nih.gov/42782976/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,41666979,"From Primary Amenorrhea to the Desert Hedgehog Gene: Novel Homozygous Variant in 46,XY Gonadal Dysgenesis.",2026,10.1016/j.jpag.2026.02.006,https://pubmed.ncbi.nlm.nih.gov/41666979/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42676746,Discoverability and characteristics of health and fitness apps for deaf/hard-of-hearing and blind/low-vision users.,2026,10.3389/fdgth.2026.1864883,https://pubmed.ncbi.nlm.nih.gov/42676746/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42507845,Effects of work-related stressors on subjective well-being of Chinese DHH workers.,2026,10.1093/jdsade/enag044,https://pubmed.ncbi.nlm.nih.gov/42507845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42427389,Predictors of resilience in deaf and hard of hearing adolescents and adolescents with developmental language disorders.,2026,10.3389/fpsyg.2026.1773481,https://pubmed.ncbi.nlm.nih.gov/42427389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42507843,Effects of the preventive hypertension self-management education program for deaf and hard of hearing adults: a randomized controlled trial.,2026,10.1093/jdsade/enag042,https://pubmed.ncbi.nlm.nih.gov/42507843/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42389992,Relationship between gratitude and mental health in deaf and hard-of-hearing students.,2026,10.1093/jdsade/enaf071,https://pubmed.ncbi.nlm.nih.gov/42389992/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42645114,Language Development in Deaf and Hard-of-Hearing Children: An Ecological Systems Perspective.,2026,10.3390/audiolres16040103,https://pubmed.ncbi.nlm.nih.gov/42645114/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42192516,Perspectives of perinatal clinicians when caring for deaf and hard of hearing patients.,2026,10.1186/s12884-026-09309-5,https://pubmed.ncbi.nlm.nih.gov/42192516/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42685218,KRAS is required for plexiform neurofibroma formation and represents a targetable vulnerability in established tumors.,2026,10.1126/sciadv.aeg3475,https://pubmed.ncbi.nlm.nih.gov/42685218/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,41984792,Experiences of professionals in DHH education: challenging communicative monotony.,2026,10.1093/jdsade/enag010,https://pubmed.ncbi.nlm.nih.gov/41984792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42553511,Case Report: Adult-onset diffuse hepatic hemangiomatosis with rapid progression: an autopsy case with diagnostic difficulty.,2026,10.3389/fmed.2026.1890714,https://pubmed.ncbi.nlm.nih.gov/42553511/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42645124,"Behavioral and Subjective Music Perception and Appreciation in Adults with Hearing Aids, Cochlear Implants, and Typical Hearing.",2026,10.3390/audiolres16040113,https://pubmed.ncbi.nlm.nih.gov/42645124/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,41720483,Bridging the Communication Gap: Pragmatics and Interactional Dynamics in Deaf and Hard of Hearing Children.,2026,10.1044/2025_jslhr-25-00325,https://pubmed.ncbi.nlm.nih.gov/41720483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,41307558,Psychological resilience impact career exploration and decision-making self-efficacy through hope.,2025,10.1093/jdsade/enaf018,https://pubmed.ncbi.nlm.nih.gov/41307558/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,41773936,"Phonological, Speechreading, and Visual-Orthographic Processing Skills of Chinese Deaf and Hard of Hearing Children.",2026,10.1044/2025_lshss-25-00039,https://pubmed.ncbi.nlm.nih.gov/41773936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42118794,Enhancing oral competence: Evidence-based strategies for developing foreign language speaking skills in Deaf and Hard-of-Hearing (DHH) learners.,2026,10.1371/journal.pone.0348196,https://pubmed.ncbi.nlm.nih.gov/42118794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42160202,Culturally safe family-centered early intervention services: perspectives from parents and service providers of deaf and hard-of-hearing children.,2026,10.1093/jdsade/enag020,https://pubmed.ncbi.nlm.nih.gov/42160202/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,41503858,Educational Services and Language Congruency in Low-Income Children Who Are Deaf or Hard-of-Hearing.,2026,10.1002/ohn.70116,https://pubmed.ncbi.nlm.nih.gov/41503858/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42043877,Language Access is a Catalyst for Early Numerical Abilities.,2026,10.1111/desc.70195,https://pubmed.ncbi.nlm.nih.gov/42043877/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,41953415,Pain score distribution: an expert elicitation study for distal humerus hemiarthroplasty and total elbow arthroplasty using a validated numerical patient rated outcome-measure in trauma.,2026,10.1016/j.jseint.2026.101640,https://pubmed.ncbi.nlm.nih.gov/41953415/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42536820,"Students with cochlear implants' experiences of built, sound, and social school environments.",2026,10.1093/jdsade/enag047,https://pubmed.ncbi.nlm.nih.gov/42536820/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42272726,Psychological hardiness among deaf and hard-of-hearing female students in Saudi Arabia: a mixed-methods analysis of influencing factors and enhancement strategies.,2026,10.3389/fpsyg.2026.1831967,https://pubmed.ncbi.nlm.nih.gov/42272726/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,40981399,Evaluating Parenting Stress and Identifying Influential Factors in Caregivers of Deaf and Hard-of-Hearing Children.,2025,10.3390/audiolres15050120,https://pubmed.ncbi.nlm.nih.gov/40981399/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,41538699,Assessing the Role of Medical Caption Technology to Support Physician-Patient Communication for Patients With Hearing Loss: Mixed Methods Pilot Study.,2026,10.2196/79073,https://pubmed.ncbi.nlm.nih.gov/41538699/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,41964613,A single arm feasibility trial of low-dosage Cogmed Working memory intervention in school-age children who are Deaf or Hard of Hearing.,2026,10.1080/21622965.2026.2654719,https://pubmed.ncbi.nlm.nih.gov/41964613/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,41402989,A call to action: more parent-child interaction research within daily routines!,2026,10.1093/jdsade/enaf057,https://pubmed.ncbi.nlm.nih.gov/41402989/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,41103346,Diabetes Technology Accessibility in Deaf and Hard of Hearing People With Diabetes.,2025,10.1155/jdr/9944722,https://pubmed.ncbi.nlm.nih.gov/41103346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,40279410,Chemical synthesis elucidates the absolute configuration and key antigenic epitope of &lt;i&gt;Vibrio cholerae&lt;/i&gt; serotype O100 O-antigen.,2025,10.1126/sciadv.adv0571,https://pubmed.ncbi.nlm.nih.gov/40279410/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHH,ENSG00000139549,Unsafe,42165078,Distal humerus hemiarthroplasty for complex intra-articular fractures in elderly or nonfixable patients: a meta-analysis of clinical and functional outcomes.,2026,10.1016/j.jseint.2026.101695,https://pubmed.ncbi.nlm.nih.gov/42165078/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,42448285,HTLV-1 HBZ inhibits DHX9 to reprogram circRNA biogenesis in ATLL.,2026,10.1016/j.tvr.2026.200347,https://pubmed.ncbi.nlm.nih.gov/42448285/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,42249076,Porcine epidemic diarrhea virus suppresses DHX9-mediated antiviral transcription through its nucleocapsid protein.,2026,10.1038/s42003-026-10391-w,https://pubmed.ncbi.nlm.nih.gov/42249076/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,42504169,Hyperoside alleviates endometrial stromal cell senescence in unexplained recurrent spontaneous abortion via DHX9-mediated R-loop resolution.,2026,10.1002/imt2.70150,https://pubmed.ncbi.nlm.nih.gov/42504169/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,42363192,DHX9 transcriptional upregulation and lactylation at K1024 fuels a glycolysis-histone lactylation loop in osteosarcoma.,2026,10.1186/s12967-026-08493-4,https://pubmed.ncbi.nlm.nih.gov/42363192/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,41276231,DHX9 aggravates epilepsy by promoting STAT1 phosphorylation to increase oxidative stress and apoptosis.,2025,10.1016/j.brainresbull.2025.111650,https://pubmed.ncbi.nlm.nih.gov/41276231/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,42139358,Helicase A determines the transcription program of T&lt;sub&gt;H&lt;/sub&gt;17 lineage differentiation and autoimmunity.,2026,10.1126/sciadv.aeb9679,https://pubmed.ncbi.nlm.nih.gov/42139358/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,42129495,Genomic heterogeneity of NAD(P)H dehydrogenase predisposes Cryptosporidium to clofazimine resistance.,2026,10.1038/s41564-026-02331-5,https://pubmed.ncbi.nlm.nih.gov/42129495/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,42801620,GSLR Drives Lung Adenocarcinoma as a Critical Regulator of Energy Homeostasis Through Creatine Kinase B Activation.,2026,10.1002/advs.77950,https://pubmed.ncbi.nlm.nih.gov/42801620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,41672965,"KIF20A inhibits TRIM21-dependent ubiquitination of DHX9 to boost SOX2 stability, enhancing OSCC stemness and ferroptosis resistance.",2026,10.1038/s41419-026-08467-w,https://pubmed.ncbi.nlm.nih.gov/41672965/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,41873535,DHX9 Inhibition Enhances Paclitaxel Sensitivity by Inducing Mitotic Failure in Ovarian and Endometrial Cancers.,2026,10.1158/1535-7163.mct-25-1196,https://pubmed.ncbi.nlm.nih.gov/41873535/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,42492626,"Context-dependent roles of DHX9 in Cancer: Molecular mechanisms, biomarker potential, and therapeutic perspectives.",2026,10.1016/j.bbcan.2026.189666,https://pubmed.ncbi.nlm.nih.gov/42492626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,41029497,DHX9 as a prognostic biomarker and its biological roles in acute myeloid leukemia.,2025,10.1186/s12885-025-14708-6,https://pubmed.ncbi.nlm.nih.gov/41029497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,42056557,KDM4B/DHX9 promotes chemoresistance in small-cell lung cancer through the MYCN-driven signaling pathway.,2026,10.1038/s41388-026-03798-6,https://pubmed.ncbi.nlm.nih.gov/42056557/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,42332175,Dual roles of the DHX9 RGG domain in hybrid-dependent recruitment and suppression of 53BP1.,2026,10.1038/s41598-026-59280-6,https://pubmed.ncbi.nlm.nih.gov/42332175/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,41650960,DHX9 sustains hematopoietic stem cell function in cooperation with H3 acetylation.,2026,10.1016/j.stemcr.2026.102794,https://pubmed.ncbi.nlm.nih.gov/41650960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,40659605,DHX9-mediated epigenetic silencing of BECN1 contributes to impaired autophagy and tumor progression in breast cancer via recruitment of HDAC5.,2025,10.1038/s41419-025-07847-y,https://pubmed.ncbi.nlm.nih.gov/40659605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,41259202,MIAT-DHX9 spatiotemporal expression drives venous neointimal hyperplasia through nucleolar homeostasis and mitotic progression.,2025,10.1016/j.celrep.2025.116578,https://pubmed.ncbi.nlm.nih.gov/41259202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,41369256,Assessing the function of the alternative electron transport chain in the &lt;i&gt;Cryptosporidium parvum&lt;/i&gt; mitosome.,2025,10.1128/mbio.01120-25,https://pubmed.ncbi.nlm.nih.gov/41369256/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,39950342,DHX9 helicase impacts on splicing decisions by modulating U2 snRNP recruitment in Ewing sarcoma cells.,2025,10.1093/nar/gkaf068,https://pubmed.ncbi.nlm.nih.gov/39950342/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,40677007,RP11-439C15.4 inhibits the malignant progression of hepatocellular carcinoma via binding to DHX9 and facilitating its degradation.,2025,10.3724/abbs.2025122,https://pubmed.ncbi.nlm.nih.gov/40677007/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,42593691,"R-loops in colorectal cancer: mechanisms, mapping strategies, and therapeutic opportunities.",2026,10.1007/s11033-026-12563-7,https://pubmed.ncbi.nlm.nih.gov/42593691/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,42090290,Accumulated sotorasib-bound KRAS&lt;sup&gt;G12C&lt;/sup&gt; reactivates the MAPK pathway and drives sotorasib resistance via the DHX9-RAC1-PAK1 axis.,2026,10.1016/j.celrep.2026.117338,https://pubmed.ncbi.nlm.nih.gov/42090290/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,40907904,LINC01018 attenuates hepatic lipid accumulation by inducing autophagy via DHX9 pathway in alcohol-associated liver disease.,2025,10.1016/j.ijbiomac.2025.147298,https://pubmed.ncbi.nlm.nih.gov/40907904/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,41803859,Inhibition of PRMT5 triggers synthetic lethality in ARID1A-deficient endometrial cancer by promoting aberrant R-loop accumulation.,2026,10.1186/s12943-026-02629-2,https://pubmed.ncbi.nlm.nih.gov/41803859/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,39941810,Targeting Hepatocellular Carcinoma Growth: Haprolid's Inhibition of AKT Signaling Through DExH-Box Helicase 9 Downregulation.,2025,10.3390/cancers17030443,https://pubmed.ncbi.nlm.nih.gov/39941810/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,42322249,Structural basis of ligand selectivity in FAD/NAD(P)H-dependent dehydrogenases: insights from trypanothione reductase and type II NADH dehydrogenase.,2026,10.1002/pro.70664,https://pubmed.ncbi.nlm.nih.gov/42322249/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,40961922,Targeting AQP5-mediated arginine deprivation in gastric cancer stem cells restores NK cell anti-tumor immunity.,2025,10.1016/j.xcrm.2025.102333,https://pubmed.ncbi.nlm.nih.gov/40961922/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,40019351,Identifying Key Properties That Drive Redox Mediator Activity in Lactiplantibacillus Plantarum.,2025,10.1002/anie.202424867,https://pubmed.ncbi.nlm.nih.gov/40019351/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DHX9,ENSG00000135829,Unsafe,38189443,Targeting DHX9 Triggers Tumor-Intrinsic Interferon Response and Replication Stress in Small Cell Lung Cancer.,2024,10.1158/2159-8290.cd-23-0486,https://pubmed.ncbi.nlm.nih.gov/38189443/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,42789195,"Expression of long non‑coding RNAs DIAPH3‑AS1, HMMR‑AS1, and SPATA3‑AS1 in patients with colorectal cancer: association with chemotherapy response and clinicopathological features.",2026,10.1007/s11033-026-12789-5,https://pubmed.ncbi.nlm.nih.gov/42789195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,42438600,Identification of immunopeptides (pHLA) as candidate therapeutic targets in chondrosarcoma.,2026,10.1016/j.jbo.2026.100780,https://pubmed.ncbi.nlm.nih.gov/42438600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,41872154,Loss of DIAPH3 accelerates glioma genesis in mice.,2026,10.1038/s41419-026-08652-x,https://pubmed.ncbi.nlm.nih.gov/41872154/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,41473744,DIAPH3 is upregulated in high-grade gliomas and linked to chromosomal instability.,2025,10.1093/noajnl/vdaf233,https://pubmed.ncbi.nlm.nih.gov/41473744/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,42345014,A Structural Variant in the 5' Regulatory Region of &lt;i&gt;DIAPH3&lt;/i&gt; Segregates with Postlingual Hearing Loss and Auditory Neuropathy in a Multigenerational Brazilian Family.,2026,10.1055/a-2832-6312,https://pubmed.ncbi.nlm.nih.gov/42345014/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,41545793,DIAPH3 is a multifaceted prognostic biomarker that links immunotherapy response to tumor microenvironment in prostate cancer.,2026,10.1007/s12672-026-04413-6,https://pubmed.ncbi.nlm.nih.gov/41545793/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,41511813,Identification of a Novel Likely Pathogenic Variant of DIAPH3 Associated With New Phenotype of Sensorineural Hearing Loss.,2026,10.1002/mgg3.70179,https://pubmed.ncbi.nlm.nih.gov/41511813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,39843730,m1A-regulated DIAPH3 promotes the invasiveness of colorectal cancer via stabilization of KRT19.,2025,10.1007/s10585-024-10323-0,https://pubmed.ncbi.nlm.nih.gov/39843730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,41318619,The DIAPH3/RPL6 axis regulates the cGAS-STING pathway in pancreatic cancer.,2025,10.1186/s40001-025-03525-z,https://pubmed.ncbi.nlm.nih.gov/41318619/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,40040362,Advances in Understanding the Molecular Dynamics of Autosomal Dominant Auditory Neuropathy: Unveiling a Novel DIAPH3 Gene Variant Associated With Sensorineural Hearing Loss and Bilateral Vestibular Aqueduct Enlargement.,2025,10.7874/jao.2024.00143,https://pubmed.ncbi.nlm.nih.gov/40040362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,38897998,The DIAPH3 linker specifies a β-actin network that maintains RhoA and Myosin-II at the cytokinetic furrow.,2024,10.1038/s41467-024-49427-2,https://pubmed.ncbi.nlm.nih.gov/38897998/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,42768702,Genetic Diversity and Selection Signatures of Three Indonesian Indigenous Pig Populations From Eastern Indonesia Using Whole Genome Sequencing Data.,2026,10.1002/age.70209,https://pubmed.ncbi.nlm.nih.gov/42768702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,39322015,Stub1 promotes degradation of the activated Diaph3: A negative feedback regulatory mechanism of the actin nucleator.,2024,10.1016/j.jbc.2024.107813,https://pubmed.ncbi.nlm.nih.gov/39322015/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,40983686,Nuclear rupture in confined cell migration triggers nuclear actin polymerization to limit chromatin leakage.,2025,10.1038/s44318-025-00566-2,https://pubmed.ncbi.nlm.nih.gov/40983686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,39989026,Chemoproteomics-Enabled &lt;i&gt;De Novo&lt;/i&gt; Proteolysis Targeting Chimera Discovery Platform Identifies a Metallothionein Degrader to Probe Its Role in Cancer.,2025,10.1021/jacs.4c17827,https://pubmed.ncbi.nlm.nih.gov/39989026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,39376176,The functional DIAPH3-FOXM1 interaction modulates the aggressive transformation of anaplastic thyroid carcinoma cells and Wnt/β-catenin signalling.,2024,10.5603/ep.100719,https://pubmed.ncbi.nlm.nih.gov/39376176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,38454929,DIAPH3 predicts survival of patients with MGMT-methylated glioblastoma.,2024,10.3389/fonc.2024.1359652,https://pubmed.ncbi.nlm.nih.gov/38454929/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,36750200,The pan-cancer analysis identified DIAPH3 as a diagnostic biomarker of clinical cancer.,2023,10.18632/aging.204459,https://pubmed.ncbi.nlm.nih.gov/36750200/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,40486509,Innate immune cell barrier-related genes inform precision prognosis in pancreatic cancer.,2025,10.3389/fimmu.2025.1559373,https://pubmed.ncbi.nlm.nih.gov/40486509/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,38728194,Role of MEK1 and DIAPH3 expression in colorectal adenoma-carcinoma sequence.,2024,10.3233/tub-230038,https://pubmed.ncbi.nlm.nih.gov/38728194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,38555741,Identification of a cisplatin resistant-based prognostic immune related gene signature in MIBC.,2024,10.1016/j.tranon.2024.101942,https://pubmed.ncbi.nlm.nih.gov/38555741/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,34659408,Knockdown of DIAPH3 Inhibits the Proliferation of Cervical Cancer Cells through Inactivating mTOR Signaling Pathway.,2021,10.1155/2021/4228241,https://pubmed.ncbi.nlm.nih.gov/34659408/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,38463521,Comprehensive analysis based on the disulfidptosis-related genes identifies hub genes and immune infiltration for pancreatic adenocarcinoma.,2024,10.1515/med-2024-0906,https://pubmed.ncbi.nlm.nih.gov/38463521/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,36589226,Diaphanous-related formin subfamily: Novel prognostic biomarkers and tumor microenvironment regulators for pancreatic adenocarcinoma.,2022,10.3389/fmolb.2022.910950,https://pubmed.ncbi.nlm.nih.gov/36589226/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,38759836,Cellular landscape of adrenocortical carcinoma at single-nuclei resolution.,2024,10.1016/j.mce.2024.112272,https://pubmed.ncbi.nlm.nih.gov/38759836/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,38851695,Unveiling novel cell clusters and biomarkers in glioblastoma and its peritumoral microenvironment at the single-cell perspective.,2024,10.1186/s12967-024-05313-5,https://pubmed.ncbi.nlm.nih.gov/38851695/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,35201449,Diaphanous related formin 3 knockdown suppresses cell proliferation and metastasis of osteosarcoma cells.,2021,10.1007/s12672-021-00415-8,https://pubmed.ncbi.nlm.nih.gov/35201449/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,33345387,DIAPH3 promotes pancreatic cancer progression by activating selenoprotein TrxR1-mediated antioxidant effects.,2021,10.1111/jcmm.16196,https://pubmed.ncbi.nlm.nih.gov/33345387/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,37091228,Identifying signatures of EV secretion in metastatic breast cancer through functional single-cell profiling.,2023,10.1016/j.isci.2023.106482,https://pubmed.ncbi.nlm.nih.gov/37091228/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,33297976,Novel stromal biomarker screening in pancreatic cancer patients using the in vitro cancer-stromal interaction model.,2020,10.1186/s12876-020-01556-w,https://pubmed.ncbi.nlm.nih.gov/33297976/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,38266456,"KIF20B and MET, hub genes of DIAPHs, predict poor prognosis and promote pancreatic cancer progression.",2024,10.1016/j.prp.2023.155046,https://pubmed.ncbi.nlm.nih.gov/38266456/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DIAPH3,ENSG00000139734,Unsafe,34685534,Formins in Human Disease.,2021,10.3390/cells10102554,https://pubmed.ncbi.nlm.nih.gov/34685534/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,42210256,YY1-induced upregulation of DLGAP5 promotes tumor progression in lung adenocarcinoma via Wnt/β-catenin/EMT pathway.,2026,10.1186/s12967-026-08274-z,https://pubmed.ncbi.nlm.nih.gov/42210256/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,40944860,DLGAP5 facilitates glioblastoma growth and tumor-associated macrophage M2 polarization.,2025,10.1007/s10735-025-10592-3,https://pubmed.ncbi.nlm.nih.gov/40944860/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,42749183,The AR/ARD1/DLGAP5 axis drives oncogenesis and immune evasion via PD-L1 upregulation in androgen receptor-positive triple-negative breast cancer.,2026,10.1016/j.trsl.2026.09.011,https://pubmed.ncbi.nlm.nih.gov/42749183/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,42632534,DLGAP5 enhances chemotherapy resistance in pancreatic ductal adenocarcinoma by regulating glycolysis through MYC.,2026,10.1016/j.cellsig.2026.112841,https://pubmed.ncbi.nlm.nih.gov/42632534/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,42297309,DLGAP5-induced glycolysis reprogramming reinforces macrophage M2 polarization to impact BC progression.,2026,10.1016/j.bbagen.2026.130969,https://pubmed.ncbi.nlm.nih.gov/42297309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,41339651,Integrated profiling reveals polarity protein dysregulation during oral cancer progression.,2025,10.1038/s41598-025-27447-2,https://pubmed.ncbi.nlm.nih.gov/41339651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,42002087,DLGAP5 protects glioblastoma cells against DNA damage through E2F1-transcripted RAD51AP1.,2026,10.1016/j.bbadis.2026.168265,https://pubmed.ncbi.nlm.nih.gov/42002087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,42121242,Loss of DLGAP5 impairs human and mouse oocyte maturation via disrupting the PI3K-AKT signaling axis.,2026,10.1186/s13048-026-02134-6,https://pubmed.ncbi.nlm.nih.gov/42121242/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,42257272,DLGAP5 Drives Lung Adenocarcinoma Cell Growth by Promoting Autophagy Activity.,2026,10.1155/carj/2731987,https://pubmed.ncbi.nlm.nih.gov/42257272/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,41868655,DLGAP5 promotes salivary adenoid cystic carcinoma proliferation and metastasis through PI3K/AKT pathway.,2026,10.62347/xdtq6840,https://pubmed.ncbi.nlm.nih.gov/41868655/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,41508152,DLGAP5 Drives Lung Cancer Progression: Combined Bioinformatics and Clinical Prognostic Analysis.,2026,10.1097/cji.0000000000000597,https://pubmed.ncbi.nlm.nih.gov/41508152/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,42840748,A novel homozygous &lt;i&gt;DLGAP5&lt;/i&gt; splice-site variant in a woman with oocyte maturation arrest and recurrent IVF failure: a case report.,2026,10.3389/fgene.2026.1963011,https://pubmed.ncbi.nlm.nih.gov/42840748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,41664207,Integrative multi-omics analysis of macrophage polarization-related genes in atherosclerosis development.,2026,10.1186/s13148-026-02072-6,https://pubmed.ncbi.nlm.nih.gov/41664207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,41326883,Bioinformatics analysis of DLGAP5 as a biomarker in lung adenocarcinoma: implications for immune infiltration and targeted therapy.,2025,10.1007/s12672-025-04145-z,https://pubmed.ncbi.nlm.nih.gov/41326883/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,42105706,Knockdown of DLGAP5 inhibits microglia activation in spinal cord injury rats through limiting NF-κB activation.,2026,10.1016/j.intimp.2026.116786,https://pubmed.ncbi.nlm.nih.gov/42105706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,42405025,Integrative Transcriptomic Analysis Identifies Hypoxia-responsive Cell Cycle Hub Genes as Prognostic Markers in Glioblastoma.,2026,10.1177/09727531261453688,https://pubmed.ncbi.nlm.nih.gov/42405025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,40959279,DLGAP5 Promotes Acute Liver Injury via Hepatocyte Pyroptosis-Driven Macrophage Metabolic Reprogramming and M1 Polarization.,2025,10.7150/ijbs.118024,https://pubmed.ncbi.nlm.nih.gov/40959279/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,41664119,DLGAP5 regulates malignancy and lenvatinib sensitivity of hepatocellular carcinoma through AKT/mTOR/NF-κB pathway.,2026,10.1186/s40001-026-03981-1,https://pubmed.ncbi.nlm.nih.gov/41664119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,42445436,Complement system-related gene signatures implicated in the recurrence of glioma.,2026,10.21037/tcr-2026-1-0374,https://pubmed.ncbi.nlm.nih.gov/42445436/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,40962169,TFAP4/DLGAP5 promotes tumor progression and macrophage M2 polarization in prostate cancer by activating the JAK2/STAT3 signaling.,2025,10.1016/j.yexcr.2025.114753,https://pubmed.ncbi.nlm.nih.gov/40962169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,41984188,"Machine learning-based multi-omic analysis identifies CEP55, DLGAP5, and EZH2 as regulated cell death biomarkers linked to immunotherapy resistance in hepatocellular carcinoma.",2026,10.1007/s00210-026-05282-0,https://pubmed.ncbi.nlm.nih.gov/41984188/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,40639803,Pathogenic variants in DLGAP5 cause female infertility characterized by oocyte maturation arrest and embryonic arrest.,2025,10.1093/humrep/deaf139,https://pubmed.ncbi.nlm.nih.gov/40639803/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,40796344,Biallelic variants in DLGAP5 cause spindle assembly defects and human early embryonic arrest.,2025,10.1093/humrep/deaf158,https://pubmed.ncbi.nlm.nih.gov/40796344/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,41533300,The MAD2L1-FOXM1 axis negatively regulates CD4⁺ T cell and macrophages infiltration in lung adenocarcinoma.,2026,10.1007/s12672-025-04360-8,https://pubmed.ncbi.nlm.nih.gov/41533300/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,39182361,Transcriptional regulation of DLGAP5 by AR suppresses p53 signaling and inhibits CD8+T cell infiltration in triple-negative breast cancer.,2024,10.1016/j.tranon.2024.102081,https://pubmed.ncbi.nlm.nih.gov/39182361/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,39990228,DLGAP5 enhances bladder cancer chemoresistance by regulating glycolysis through MYC stabilization.,2025,10.7150/thno.102730,https://pubmed.ncbi.nlm.nih.gov/39990228/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,38414025,DLGAP5 promotes lung adenocarcinoma growth via upregulating PLK1 and serves as a therapeutic target.,2024,10.1186/s12967-024-04910-8,https://pubmed.ncbi.nlm.nih.gov/38414025/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,37266661,The mitotic spindle-related seven-gene predicts the prognosis and immune microenvironment of lung adenocarcinoma.,2023,10.1007/s00432-023-04906-9,https://pubmed.ncbi.nlm.nih.gov/37266661/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,40621461,Exercise-related immune gene signature for hepatocellular carcinoma: machine learning and multi-omics analysis.,2025,10.3389/fimmu.2025.1606711,https://pubmed.ncbi.nlm.nih.gov/40621461/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,39559249,Bioinformatics Analysis Reveals CDK1 and DLGAP5 as Key Modulators of Tumor Immune Cell Infiltration in Hepatocellular Carcinoma.,2024,10.2147/cmar.s478426,https://pubmed.ncbi.nlm.nih.gov/39559249/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,41485159,Inflammation-associated immune-related genes as potential biomarkers for the diagnosis of interstitial cystitis.,2026,10.1007/s10238-025-02032-z,https://pubmed.ncbi.nlm.nih.gov/41485159/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,41184881,HROB is a novel prognostic biomarker correlated with immune cell infiltration and tumor progression in lung adenocarcinoma.,2025,10.1186/s12957-025-04070-z,https://pubmed.ncbi.nlm.nih.gov/41184881/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DLGAP5,ENSG00000126787,Unsafe,12527899,"Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma.",2003,10.1038/sj.onc.1206129,https://pubmed.ncbi.nlm.nih.gov/12527899/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,42491125,Modelling DMC1 mediated homologous recombination repair in mouse embryonic stem cells.,2026,10.3389/fcell.2026.1744837,https://pubmed.ncbi.nlm.nih.gov/42491125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,42854377,Meiotic recombination proteins in cancer.,2026,10.1016/j.dnarep.2026.103963,https://pubmed.ncbi.nlm.nih.gov/42854377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,41637829,Comprehensive transcriptome analysis of somatic and gonadal tissues for identification of sex-biased genes in spotted scat (Scatophagus argus).,2026,10.1016/j.cbd.2026.101767,https://pubmed.ncbi.nlm.nih.gov/41637829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,42883452,Establishment and Characterization of a Spermatogonial Stem Cell-like Line with Potential for Meiotic Differentiation in the Endangered Fish &lt;i&gt;Rhinogobio nasutus&lt;/i&gt;.,2026,10.3390/biology15191779,https://pubmed.ncbi.nlm.nih.gov/42883452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,42792869,Ubc9 Mediates SUMO2/3 Modification to Regulate Meiosis in Male Mice.,2026,10.3390/biomedicines14092129,https://pubmed.ncbi.nlm.nih.gov/42792869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,40815353,Identification of missense DMC1 variants in males with non-obstructive azoospermia.,2025,10.1007/s10815-025-03591-6,https://pubmed.ncbi.nlm.nih.gov/40815353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,42275601,The HORMA-domain protein ASY1 recruits the plant-specific cyclin SDS to promote DMC1-mediated meiotic recombination.,2026,10.1093/plcell/koag176,https://pubmed.ncbi.nlm.nih.gov/42275601/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,42051960,Meiotic gene expression of &lt;i&gt;STAG3&lt;/i&gt; and &lt;i&gt;DMC1&lt;/i&gt; in blood: A novel non-invasive biomarker approach for diminished ovarian reserve: A case-control study.,2026,10.18502/ijrm.v24i2.21050,https://pubmed.ncbi.nlm.nih.gov/42051960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,42489337,Repair and misrepair of telomeric DNA in dynamic interactions with PML nuclear bodies and lamin B1 in doxorubicin-treated cancer cells.,2026,10.1080/19491034.2026.2688655,https://pubmed.ncbi.nlm.nih.gov/42489337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,42886774,Suppression of meiotic double-strand break formation in somatic cells by DREAM factors TCX5/6 maintains genome stability.,2026,10.1126/sciadv.aef7208,https://pubmed.ncbi.nlm.nih.gov/42886774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,42649296,Long-read sequencing reveals pre-meiotic gene conversion in sperm.,2026,10.1038/s41586-026-10901-0,https://pubmed.ncbi.nlm.nih.gov/42649296/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,40906377,Functional Spermatogenesis Across Testicular Developmental Stages in Neomale Large Yellow Croaker (&lt;i&gt;Larimichthys crocea&lt;/i&gt;) Revealed by Histology and Gonadal Specific Cellular Markers.,2025,10.3390/biology14081054,https://pubmed.ncbi.nlm.nih.gov/40906377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,40679056,Compensation for X-linked Pdha1 silencing by Pdha2 is essential for meiotic double-strand break repair in spermatogenesis.,2025,10.1242/dev.204683,https://pubmed.ncbi.nlm.nih.gov/40679056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,41452733,Optimization of the Decellularization Process and Evaluation of the Differentiation Potential of Wharton's Jelly Mesenchymal Stem Cells on a Decellularized 3D Scaffold of Testicular Tissue.,2026,10.1111/aor.70067,https://pubmed.ncbi.nlm.nih.gov/41452733/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,41746729,HOP2-MND1 chaperones a diffusing DMC1-ssDNA complex to survey dsDNA for homology recognition during meiotic recombination.,2026,10.1073/pnas.2529249123,https://pubmed.ncbi.nlm.nih.gov/41746729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,42121777,Stage-Specific Transcriptomic Analysis Reveals Molecular Basis of Ovarian Sterility in Triploid Turbot (&lt;i&gt;Scophthalmus maximus&lt;/i&gt;).,2026,10.3390/ani16091357,https://pubmed.ncbi.nlm.nih.gov/42121777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,39153704,Identification and expression analysis of dmc1 in Chinese soft-shell turtle (Pelodiscus sinensis) during gametogenesis.,2025,10.1016/j.gene.2024.148866,https://pubmed.ncbi.nlm.nih.gov/39153704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,42388858,MCM8 variants in two patients with primary ovarian insufficiency: clinical findings and &lt;i&gt;in vitro&lt;/i&gt; defective DNA repair revealed by an MCM8 double-mutant construct.,2026,10.3389/fendo.2026.1807887,https://pubmed.ncbi.nlm.nih.gov/42388858/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,41371341,Lineage-specific amino acids define functional attributes of the protomer-protomer interfaces for the Rad51 and Dmc1 recombinases.,2026,10.1016/j.jbc.2025.111019,https://pubmed.ncbi.nlm.nih.gov/41371341/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,42059593,"The synaptonemal complex: structure, function, and clinical implications†.",2026,10.1093/biolre/ioag092,https://pubmed.ncbi.nlm.nih.gov/42059593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,42162658,Maternal PFBS exposure disrupts oocyte meiotic prophase I and reduces primordial follicle pool.,2026,10.1016/j.fct.2026.116168,https://pubmed.ncbi.nlm.nih.gov/42162658/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,41086699,Myclobutanil-induced testis damage and apoptotic germ cell death through ER stress and autophagy in mouse testes.,2025,10.1016/j.ecoenv.2025.119213,https://pubmed.ncbi.nlm.nih.gov/41086699/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,42399939,R-loops and D-loops: a delicate balance in genomic stability and instability.,2026,10.1186/s12964-026-03033-5,https://pubmed.ncbi.nlm.nih.gov/42399939/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,41965838,Genome-wide investigation of synthetic rescue interactions in Alzheimer's disease implicates glial lipid and sterol metabolism.,2026,10.1186/s13195-026-02009-4,https://pubmed.ncbi.nlm.nih.gov/41965838/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,36748274,Cholesterol-Amino-Phosphate (CAP) Derived Lipid Nanoparticles for Delivery of Self-Amplifying RNA and Restoration of Spermatogenesis in Infertile Mice.,2023,10.1002/advs.202300188,https://pubmed.ncbi.nlm.nih.gov/36748274/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,36063617,Ciprofloxacin and enrofloxacin can cause reproductive toxicity via endocrine signaling pathways.,2022,10.1016/j.ecoenv.2022.114049,https://pubmed.ncbi.nlm.nih.gov/36063617/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,35853364,Vitamin C supplementation rescued meiotic arrest of spermatocytes in Balb/c mice exposed to BDE-209.,2022,10.1016/j.ecoenv.2022.113846,https://pubmed.ncbi.nlm.nih.gov/35853364/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,35999765,Histology study and transcriptome analysis of the testis of Loach(Misgurnus anguillicaudatus) in response to phenanthrene exposure.,2022,10.1016/j.ecoenv.2022.113950,https://pubmed.ncbi.nlm.nih.gov/35999765/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,39212356,[Lycium barbarum miR2911-loaded exosomes promote spermatogenic function recovery in rats with non-obstructive azoospermia by regulating Wnt/β-catenin signaling pathways].,2024,,https://pubmed.ncbi.nlm.nih.gov/39212356/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,34976055,Identification of a Ten-Gene Signature of DNA Damage Response Pathways with Prognostic Value in Esophageal Squamous Cell Carcinoma.,2021,10.1155/2021/3726058,https://pubmed.ncbi.nlm.nih.gov/34976055/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,37315217,MiR-5622-3p inhibits ZCWPW1 to induce apoptosis in silica-exposed mice and spermatocyte cells.,2023,10.1080/17435390.2023.2223632,https://pubmed.ncbi.nlm.nih.gov/37315217/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,39021337,DNA cytosine methyltransferases differentially regulate genome-wide hypermutation and interhomolog recombination in Trichoderma reesei meiosis.,2024,10.1093/nar/gkae611,https://pubmed.ncbi.nlm.nih.gov/39021337/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,30500739,Food Yellow4 reprotoxicity in relation to localization of DMC1 and apoptosis in rat testes: Roles of royal jelly and cod liver oil.,2019,10.1016/j.ecoenv.2018.11.082,https://pubmed.ncbi.nlm.nih.gov/30500739/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,35001532,Melatonin ameliorates paclitaxel-induced mice spermatogenesis and fertility defects.,2022,10.1111/jcmm.17177,https://pubmed.ncbi.nlm.nih.gov/35001532/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,34936917,BDE-209 induce spermatocytes arrest at early-pachytene stage during meiotic prophase I in mice.,2022,10.1016/j.tox.2021.153061,https://pubmed.ncbi.nlm.nih.gov/34936917/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,29458764,Purification of Saccharomyces cerevisiae Homologous Recombination Proteins Dmc1 and Rdh54/Tid1 and a Fluorescent D-Loop Assay.,2018,10.1016/bs.mie.2017.12.003,https://pubmed.ncbi.nlm.nih.gov/29458764/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,25906155,Acquisition of meiotic DNA repair regulators maintain genome stability in glioblastoma.,2015,10.1038/cddis.2015.75,https://pubmed.ncbi.nlm.nih.gov/25906155/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMC1,ENSG00000100206,Unsafe,33185188,Rdh54/Tid1 inhibits Rad51-Rad54-mediated D-loop formation and limits D-loop length.,2020,10.7554/elife.59112,https://pubmed.ncbi.nlm.nih.gov/33185188/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,42781774,&lt;i&gt;Dmp1&lt;/i&gt; Knock-in Mice Faithfully Report and Manipulate &lt;i&gt;Dmp1&lt;/i&gt;-Expressing Cells.,2026,10.1177/00220345261478577,https://pubmed.ncbi.nlm.nih.gov/42781774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,41878059,New knock-in mouse lines &lt;i&gt;Dmp1&lt;sup&gt;em1(CreERT2)&lt;/sup&gt;&lt;/i&gt; and &lt;i&gt;Dmp1&lt;sup&gt;em2(ZsGreen)&lt;/sup&gt;&lt;/i&gt; enable precise osteocyte-specific targeting and visualization.,2026,10.1093/jbmrpl/ziag031,https://pubmed.ncbi.nlm.nih.gov/41878059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,42628728,Molecular Cues from Extracellular Matrix Proteins Drive the Differentiation of Dental Pulp Stem Cells into Endothelial Cells in the Presence of Dentin Matrix Protein 1.,2026,10.1016/j.joen.2026.08.017,https://pubmed.ncbi.nlm.nih.gov/42628728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,41683766,Identification of DMP1 as Novel p53 Repressed Transcriptional Target.,2026,10.3390/ijms27031344,https://pubmed.ncbi.nlm.nih.gov/41683766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,41861576,Endothelial Nitric Oxide Synthase Restores Diabetic Dentin Regeneration via AKT/Endothelial Nitric Oxide Synthase Axis.,2026,10.1016/j.identj.2026.109511,https://pubmed.ncbi.nlm.nih.gov/41861576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,42532988,"DMP1-Cre expressing cells mediate the gain in bone mass and strength, but not the increase in bone remodeling, induced by ligands of the parathyroid hormone receptor.",2026,10.1038/s41413-026-00555-z,https://pubmed.ncbi.nlm.nih.gov/42532988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,42036492,Region- and Compartment-Specific Elevation of Bone Mass in Mice Following Tsc1 Deletion in 8-kb Dmp1-Cre-Expressing Cells.,2026,10.1007/s00223-026-01532-8,https://pubmed.ncbi.nlm.nih.gov/42036492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,42386140,Disrupted phosphate metabolism and SIBLING/ASARM peptide accumulation underlie impaired bone mineralization in klotho-deficient (kl/kl) mice.,2026,10.1016/j.bone.2026.118002,https://pubmed.ncbi.nlm.nih.gov/42386140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,42880908,"[Impact of icariin on the differentiation towards dentinogenesis and angiogenesis, and inflammatory regulation of stem cells from human exfoliated deciduous teeth].",2026,10.19723/j.issn.1671-167x.2026.05.002,https://pubmed.ncbi.nlm.nih.gov/42880908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,42900995,Multi-omics analysis reveals osteocyte loss as a potential trigger for liver lipid metabolic disorder.,2026,10.1016/j.bbadis.2026.168472,https://pubmed.ncbi.nlm.nih.gov/42900995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,42674165,NOTCH3 disrupts the osteoblast transcriptome in femoral bone of 1-month-old male C57BL/6 mice.,2026,10.1016/j.bone.2026.118074,https://pubmed.ncbi.nlm.nih.gov/42674165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,42036412,Loss of PTH 1 receptor signaling in periodontal cells drives cementum dysfunction and molar ankylosis in mice.,2026,10.1038/s41413-026-00533-5,https://pubmed.ncbi.nlm.nih.gov/42036412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,42617537,Mechanical loading under estrogen deficiency enhances mineralization and osteoblast maturation in an advanced 3D vascularized bone organoid driven by hypertrophy and apoptosis.,2026,10.1016/j.jbiomech.2026.113529,https://pubmed.ncbi.nlm.nih.gov/42617537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,42331109,Tamoxifen induces region-specific osteocytic recombination and transiently alters bone structure in Dmp1-Cre-ERT2 mice.,2026,10.1016/j.jbc.2026.113275,https://pubmed.ncbi.nlm.nih.gov/42331109/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,41461362,Osteocyte-Intrinsic MMP13 exacerbates injury-induced temporomandibular joint osteoarthritis.,2026,10.1016/j.joca.2025.12.019,https://pubmed.ncbi.nlm.nih.gov/41461362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,41943820,Impaired bone matrix maturation and mineralization are prevalent in adolescent end-stage kidney disease.,2026,10.1093/jbmrpl/ziag036,https://pubmed.ncbi.nlm.nih.gov/41943820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,42689111,Optogenetic control of odontoblastic differentiation in dental pulp stem cells (DPSC).,2026,10.1016/j.jds.2025.07.3543,https://pubmed.ncbi.nlm.nih.gov/42689111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,41594856,DMP1-Mediated FAK Activation Contributes to P Utilization of Broiler Osteoblasts by Suppressing FGF23 Expression.,2026,10.3390/biology15020121,https://pubmed.ncbi.nlm.nih.gov/41594856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,42569337,An innate defense regulator peptide modulates the inflamed pulp microenvironment and promotes pulp repair.,2026,10.1016/j.bioactmat.2026.06.050,https://pubmed.ncbi.nlm.nih.gov/42569337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,42412262,When X Does Not Mark the Spot: Autosomal Dominant and Recessive Forms of Renal Hypophosphatemic Rickets and Osteomalacia.,2026,10.1007/s11914-026-00963-4,https://pubmed.ncbi.nlm.nih.gov/42412262/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,41644616,Histatin-1 promotes the expression of markers associated with odontoblastic differentiation in the dental pulp and apical papilla.,2026,10.1038/s41598-026-38578-5,https://pubmed.ncbi.nlm.nih.gov/41644616/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,41741421,Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppression.,2026,10.1038/s41420-026-02956-9,https://pubmed.ncbi.nlm.nih.gov/41741421/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,42576237,Aging Exacerbates Binge Ethanol-Mediated Bone Toxicity in Mice.,2026,10.1111/acer.70384,https://pubmed.ncbi.nlm.nih.gov/42576237/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,41733701,"Efficacy of dental stem cell-derived exosomes for pulp regeneration: a systematic review of clinical, animal, and in vitro studies.",2026,10.1007/s11033-026-11547-x,https://pubmed.ncbi.nlm.nih.gov/41733701/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,41744933,Comparative Analysis of Amelogenin-Derived Peptides LRAP and SP on Osteogenic Differentiation of Human Dental Pulp and Bone Marrow-Derived Stem Cells.,2026,10.3390/dj14020094,https://pubmed.ncbi.nlm.nih.gov/41744933/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,42182074,Osteocytic Pink1/Prkn modulates M6P metabolism and contributes to GC-induced bone loss.,2026,10.1016/j.jot.2026.101103,https://pubmed.ncbi.nlm.nih.gov/42182074/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,39389243,Role of DMP1-mediated GRP78 activation in osteoimmunomodulation of periodontal ligament stem cells.,2024,10.1016/j.jsb.2024.108133,https://pubmed.ncbi.nlm.nih.gov/39389243/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,42733764,A bone fragment-based protocol for RNA analysis of osteocyte-associated transcripts in surgically obtained human bone specimens.,2026,10.1016/j.mex.2026.104130,https://pubmed.ncbi.nlm.nih.gov/42733764/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,38170028,Injectable CNPs/DMP1-loaded self-assembly hydrogel regulating inflammation of dental pulp stem cells for dentin regeneration.,2024,10.1016/j.mtbio.2023.100907,https://pubmed.ncbi.nlm.nih.gov/38170028/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,41975348,Dose-dependent effects of Metformin on proliferation and odontogenic differentiation of dental pulp stem cells.,2026,10.1186/s12903-026-08221-w,https://pubmed.ncbi.nlm.nih.gov/41975348/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,40225282,EGCG and Taxifolin Modulate Secretory Activity and Expression of Dentinogenesis Markers in Odontoblast-Like Cells.,2025,10.1155/sci5/3233536,https://pubmed.ncbi.nlm.nih.gov/40225282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,42401884,PTGIS inhibited osteogenic and promoted angiogenic differentiation of bone marrow mesenchymal stem cells via endoplasmic reticulum stress mediated PI3K/AKT signaling.,2026,10.1186/s13287-026-05144-9,https://pubmed.ncbi.nlm.nih.gov/42401884/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,41440629,Injectable Piezoelectric Hydrogel for Vital Pulp Therapy.,2025,10.3390/jfb16120452,https://pubmed.ncbi.nlm.nih.gov/41440629/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,41340014,Revealing Causal Protein Biomarkers and Potential Therapeutic Targets for Histologic-Specific Lung Cancer.,2025,10.1111/jcmm.70866,https://pubmed.ncbi.nlm.nih.gov/41340014/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,38104230,Hematopoietic and stromal DMP1-Cre labeled cells form a unique niche in the bone marrow.,2023,10.1038/s41598-023-49713-x,https://pubmed.ncbi.nlm.nih.gov/38104230/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,40650465,Unraveling the Transcription Factor Code of Odontoblast Differentiation.,2026,10.1177/00220345251348148,https://pubmed.ncbi.nlm.nih.gov/40650465/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,41495150,Lipocalin-2 upregulation in hypoxic murine osteocytes enhances RANKL-induced osteoclastogenesis.,2026,10.1038/s41598-025-34575-2,https://pubmed.ncbi.nlm.nih.gov/41495150/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMP1,ENSG00000152592,Unsafe,39922901,Effect of Bio MTA plus &amp; ProRoot MTA pulp capping materials on the regenerative properties of human dental pulp stem cells.,2025,10.1038/s41598-025-88816-5,https://pubmed.ncbi.nlm.nih.gov/39922901/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTC1,ENSG00000269502,Unsafe,39391249,Molecular genetic characterization of myeloid neoplasms with idic(X)(q13) and i(X)(q10).,2024,10.3389/fonc.2024.1428984,https://pubmed.ncbi.nlm.nih.gov/39391249/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTC1,ENSG00000269502,Unsafe,11863363,Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination.,2002,10.1006/geno.2002.6711,https://pubmed.ncbi.nlm.nih.gov/11863363/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTC1B,ENSG00000184911,Unsafe,39391249,Molecular genetic characterization of myeloid neoplasms with idic(X)(q13) and i(X)(q10).,2024,10.3389/fonc.2024.1428984,https://pubmed.ncbi.nlm.nih.gov/39391249/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DMRTC1B,ENSG00000184911,Unsafe,11863363,Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination.,2002,10.1006/geno.2002.6711,https://pubmed.ncbi.nlm.nih.gov/11863363/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,42094215,Exome sequencing-based identification of &lt;i&gt;DNAAF1&lt;/i&gt; variants implicated in male infertility and primary ciliary dyskinesia.,2026,10.3389/fmolb.2026.1769803,https://pubmed.ncbi.nlm.nih.gov/42094215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,42482351,Clinical and Genetic Study of a Pseudo-Dominant Primary Ciliary Dyskinesia Pedigree: The First DNAAF1-Associated Family Reported in Chinese Population.,2026,10.1002/mgg3.70264,https://pubmed.ncbi.nlm.nih.gov/42482351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,40947900,Lentiviral Gene Delivery Rescues Ciliary Defects in Patient-Derived Airway Organoids from Primary Ciliary Dyskinesia.,2025,10.1177/10430342251378128,https://pubmed.ncbi.nlm.nih.gov/40947900/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,38432987,Primary Ciliary Dyskinesia Caused by Homozygous DNAAF1 Mutations Resulting from a Consanguineous Marriage: A Case Report from Japan.,2024,10.2169/internalmedicine.3263-23,https://pubmed.ncbi.nlm.nih.gov/38432987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,40142748,Diagnostic Role of Immunofluorescence Analysis in Primary Ciliary Dyskinesia-Suspected Individuals.,2025,10.3390/jcm14061941,https://pubmed.ncbi.nlm.nih.gov/40142748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,30939186,Altered Dynein Axonemal Assembly Factor 1 Expression in C-Boutons in Bulbar and Spinal Cord Motor-Neurons in Sporadic Amyotrophic Lateral Sclerosis.,2019,10.1093/jnen/nlz019,https://pubmed.ncbi.nlm.nih.gov/30939186/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,35955660,LRRC46 Accumulates at the Midpiece of Sperm Flagella and Is Essential for Spermiogenesis and Male Fertility in Mouse.,2022,10.3390/ijms23158525,https://pubmed.ncbi.nlm.nih.gov/35955660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,29228333,DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport.,2018,10.1093/hmg/ddx422,https://pubmed.ncbi.nlm.nih.gov/29228333/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,33174003,Novel dynein axonemal assembly factor 1 mutations identified using whole‑exome sequencing in patients with primary ciliary dyskinesia.,2020,10.3892/mmr.2020.11562,https://pubmed.ncbi.nlm.nih.gov/33174003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,23599692,Mutations in LRRC50 predispose zebrafish and humans to seminomas.,2013,10.1371/journal.pgen.1003384,https://pubmed.ncbi.nlm.nih.gov/23599692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,37957793,Clinical Manifestations and Genotype of Primary Ciliary Dyskinesia Diagnosed in Korea: Multicenter Study.,2023,10.4168/aair.2023.15.6.757,https://pubmed.ncbi.nlm.nih.gov/37957793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,27543293,Mutations in the Motile Cilia Gene DNAAF1 Are Associated with Neural Tube Defects in Humans.,2016,10.1534/g3.116.033696,https://pubmed.ncbi.nlm.nih.gov/27543293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,33251213,"Coding Variants Coupled With Rapid Modeling in Zebrafish Implicate Dynein Genes, dnaaf1 and zmynd10, as Adolescent Idiopathic Scoliosis Candidate Genes.",2020,10.3389/fcell.2020.582255,https://pubmed.ncbi.nlm.nih.gov/33251213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,27996046,Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility.,2016,10.1038/ncomms13840,https://pubmed.ncbi.nlm.nih.gov/27996046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,27261005,"Mutations in Dnaaf1 and Lrrc48 Cause Hydrocephalus, Laterality Defects, and Sinusitis in Mice.",2016,10.1534/g3.116.030791,https://pubmed.ncbi.nlm.nih.gov/27261005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,31770211,Screening and identification of key biomarkers in nasopharyngeal carcinoma: Evidence from bioinformatic analysis.,2019,10.1097/md.0000000000017997,https://pubmed.ncbi.nlm.nih.gov/31770211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,27698795,Whole-exome sequencing identifies variants in invasive pituitary adenomas.,2016,10.3892/ol.2016.5029,https://pubmed.ncbi.nlm.nih.gov/27698795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,25761592,Comparative analysis of testis transcriptomes from triploid and fertile diploid cyprinid fish.,2015,10.1095/biolreprod.114.125609,https://pubmed.ncbi.nlm.nih.gov/25761592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,22387996,Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia.,2012,10.1038/ng.1106,https://pubmed.ncbi.nlm.nih.gov/22387996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,18385425,"LRRC50, a conserved ciliary protein implicated in polycystic kidney disease.",2008,10.1681/asn.2007080917,https://pubmed.ncbi.nlm.nih.gov/18385425/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF1,ENSG00000154099,Unsafe,19944405,Loss-of-function mutations in the human ortholog of Chlamydomonas reinhardtii ODA7 disrupt dynein arm assembly and cause primary ciliary dyskinesia.,2009,10.1016/j.ajhg.2009.11.008,https://pubmed.ncbi.nlm.nih.gov/19944405/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF10,ENSG00000243667,Unsafe,37239897,Characterization of Systemic and Culprit-Coronary Artery miR-483-5p Expression in Chronic CAD and Acute Myocardial Infarction Male Patients.,2023,10.3390/ijms24108551,https://pubmed.ncbi.nlm.nih.gov/37239897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF10,ENSG00000243667,Unsafe,29743191,"Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP.",2018,10.1083/jcb.201709026,https://pubmed.ncbi.nlm.nih.gov/29743191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF10,ENSG00000243667,Unsafe,31116681,WDR92 is required for axonemal dynein heavy chain stability in cytoplasm.,2019,10.1091/mbc.e19-03-0139,https://pubmed.ncbi.nlm.nih.gov/31116681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF10,ENSG00000243667,Unsafe,30428028,Chlamydomonas WDR92 in association with R2TP-like complex and multiple DNAAFs to regulate ciliary dynein preassembly.,2019,10.1093/jmcb/mjy067,https://pubmed.ncbi.nlm.nih.gov/30428028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF10,ENSG00000243667,Unsafe,26912790,A prefoldin-associated WD-repeat protein (WDR92) is required for the correct architectural assembly of motile cilia.,2016,10.1091/mbc.e16-01-0040,https://pubmed.ncbi.nlm.nih.gov/26912790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF10,ENSG00000243667,Unsafe,32927708,Transcriptomic and Proteomic Analysis of Clear Cell Foci (CCF) in the Human Non-Cirrhotic Liver Identifies Several Differentially Expressed Genes and Proteins with Functions in Cancer Cell Biology and Glycogen Metabolism.,2020,10.3390/molecules25184141,https://pubmed.ncbi.nlm.nih.gov/32927708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF10,ENSG00000243667,Unsafe,38498551,Gene dosage of independent dynein arm motor preassembly factors influences cilia assembly in Chlamydomonas reinhardtii.,2024,10.1371/journal.pgen.1011038,https://pubmed.ncbi.nlm.nih.gov/38498551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF10,ENSG00000243667,Unsafe,35218958,Integrative analysis prioritizes the relevant genes and risk factors for chronic venous disease.,2022,10.1016/j.jvsv.2022.02.006,https://pubmed.ncbi.nlm.nih.gov/35218958/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF10,ENSG00000243667,Unsafe,31754133,Genome Wide Analysis Approach Suggests Chromosome 2 Locus to be Associated with Thiazide and Thiazide Like-Diuretics Blood Pressure Response.,2019,10.1038/s41598-019-53345-5,https://pubmed.ncbi.nlm.nih.gov/31754133/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF10,ENSG00000243667,Unsafe,32365604,Genomic Scan for Selection Signature Reveals Fat Deposition in Chinese Indigenous Sheep with Extreme Tail Types.,2020,10.3390/ani10050773,https://pubmed.ncbi.nlm.nih.gov/32365604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF10,ENSG00000243667,Unsafe,27807880,Selection signature analysis reveals genes associated with tail type in Chinese indigenous sheep.,2017,10.1111/age.12477,https://pubmed.ncbi.nlm.nih.gov/27807880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF10,ENSG00000243667,Unsafe,30069889,Genetic variants in fat- and short-tailed sheep from high-throughput RNA-sequencing data.,2018,10.1111/age.12699,https://pubmed.ncbi.nlm.nih.gov/30069889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF10,ENSG00000243667,Unsafe,24987961,"Discovery of a dicer-independent, cell-type dependent alternate targeting sequence generator: implications in gene silencing & pooled RNAi screens.",2014,10.1371/journal.pone.0100676,https://pubmed.ncbi.nlm.nih.gov/24987961/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF10,ENSG00000243667,Unsafe,16487927,"Monad, a WD40 repeat protein, promotes apoptosis induced by TNF-alpha.",2006,10.1016/j.bbrc.2006.02.009,https://pubmed.ncbi.nlm.nih.gov/16487927/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,42445417,Development and validation of a DYX1C1- and GNAI1-based nomogram for predicting relapse in HER2-positive breast cancer treated with trastuzumab.,2026,10.21037/tcr-2026-1-0391,https://pubmed.ncbi.nlm.nih.gov/42445417/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,39939521,Spatiotemporal expression pattern of dyslexia susceptibility 1 candidate 1 (DYX1C1) during rat cerebral cortex development.,2025,10.1038/s41390-025-03920-6,https://pubmed.ncbi.nlm.nih.gov/39939521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,37237337,Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2.,2023,10.1186/s12860-023-00483-4,https://pubmed.ncbi.nlm.nih.gov/37237337/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,35873488,Strongly Truncated Dnaaf4 Plays a Conserved Role in Drosophila Ciliary Dynein Assembly as Part of an R2TP-Like Co-Chaperone Complex With Dnaaf6.,2022,10.3389/fgene.2022.943197,https://pubmed.ncbi.nlm.nih.gov/35873488/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,39542997,"Investigation of Association Between Expression of DYX1C1, KIAA0319, and ROBO1 Genes and Specific Learning Disorder in Children and Adolescents.",2024,10.1007/s12031-024-02288-2,https://pubmed.ncbi.nlm.nih.gov/39542997/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,41300775,Endometrial Signatures of Subfertility in Beef Heifers Reveal Dysregulation of MAPK Signaling and Ciliary Function.,2025,10.3390/genes16111323,https://pubmed.ncbi.nlm.nih.gov/41300775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,37674365,A novel homozygous splice variant in DNAAF4 is associated with asthenozoospermia.,2023,10.3724/abbs.2023147,https://pubmed.ncbi.nlm.nih.gov/37674365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,40424442,"Targeted analysis of dyslexia-associated regions on chromosomes 6, 12 and 15 in large multigenerational cohorts.",2025,10.1371/journal.pone.0324006,https://pubmed.ncbi.nlm.nih.gov/40424442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,38610086,"Developmental dyslexia susceptibility genes DNAAF4, DCDC2, and NRSN1 are associated with brain function in fluently reading adolescents and young adults.",2024,10.1093/cercor/bhae144,https://pubmed.ncbi.nlm.nih.gov/38610086/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,39983636,The mediation role of reading-related endophenotypes in the gene-to-reading pathway.,2025,10.1016/j.bandl.2025.105552,https://pubmed.ncbi.nlm.nih.gov/39983636/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,36583018,Homozygous mutation in DNAAF4 causes primary ciliary dyskinesia in a Chinese family.,2022,10.3389/fgene.2022.1087818,https://pubmed.ncbi.nlm.nih.gov/36583018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,40926959,Genetic Variants Linked to Dyslexia Co-Morbid ADHD: A Case Study of a Pakistani Outpatient.,2024,10.53555/rd5d9s46,https://pubmed.ncbi.nlm.nih.gov/40926959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,34539327,Identification of Phonology-Related Genes and Functional Characterization of Broca's and Wernicke's Regions in Language and Learning Disorders.,2021,10.3389/fnins.2021.680762,https://pubmed.ncbi.nlm.nih.gov/34539327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,37147940,Identification of a novel splice site mutation in the DNAAF4 gene of a Chinese patient with primary ciliary dyskinesia.,2023,10.4103/aja2022122,https://pubmed.ncbi.nlm.nih.gov/37147940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,37068190,Dyslexia-Related Hearing Loss Occurs Mainly through the Abnormal Spontaneous Electrical Activity of Spiral Ganglion Neurons.,2023,10.1002/advs.202205754,https://pubmed.ncbi.nlm.nih.gov/37068190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,37998638,The Moderating Role of the DYX1C1 Gene in the Effect of Home Supervision on Chinese Children's Reading Achievements: Evidence from the Diathesis-Stress Model.,2023,10.3390/bs13110891,https://pubmed.ncbi.nlm.nih.gov/37998638/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,38498551,Gene dosage of independent dynein arm motor preassembly factors influences cilia assembly in Chlamydomonas reinhardtii.,2024,10.1371/journal.pgen.1011038,https://pubmed.ncbi.nlm.nih.gov/38498551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,33635866,Defects in the cytoplasmic assembly of axonemal dynein arms cause morphological abnormalities and dysmotility in sperm cells leading to male infertility.,2021,10.1371/journal.pgen.1009306,https://pubmed.ncbi.nlm.nih.gov/33635866/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,35903363,Case Report: DNAAF4 Variants Cause Primary Ciliary Dyskinesia and Infertility in Two Han Chinese Families.,2022,10.3389/fgene.2022.934920,https://pubmed.ncbi.nlm.nih.gov/35903363/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,32445086,Dyslexia Candidate Gene and Ciliary Gene Expression Dynamics During Human Neuronal Differentiation.,2020,10.1007/s12035-020-01905-6,https://pubmed.ncbi.nlm.nih.gov/32445086/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,39115449,Whole genome sequencing enhances molecular diagnosis of primary ciliary dyskinesia.,2024,10.1002/ppul.27200,https://pubmed.ncbi.nlm.nih.gov/39115449/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,33339203,The Mediation Role of Dynamic Multisensory Processing Using Molecular Genetic Data in Dyslexia.,2020,10.3390/brainsci10120993,https://pubmed.ncbi.nlm.nih.gov/33339203/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,25989970,Deficits in learning and memory in mice with a mutation of the candidate dyslexia susceptibility gene Dyx1c1.,2017,10.1016/j.bandl.2015.04.008,https://pubmed.ncbi.nlm.nih.gov/25989970/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,23594585,"Knockdown of the candidate dyslexia susceptibility gene homolog dyx1c1 in rodents: effects on auditory processing, visual attention, and cortical and thalamic anatomy.",2013,10.1159/000348431,https://pubmed.ncbi.nlm.nih.gov/23594585/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,20977651,Persistent spatial working memory deficits in rats following in utero RNAi of Dyx1c1.,2011,10.1111/j.1601-183x.2010.00662.x,https://pubmed.ncbi.nlm.nih.gov/20977651/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,25916574,An assessment of gene-by-gene interactions as a tool to unfold missing heritability in dyslexia.,2015,10.1007/s00439-015-1555-4,https://pubmed.ncbi.nlm.nih.gov/25916574/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,23028439,Association of the DYX1C1 dyslexia susceptibility gene with orthography in the Chinese population.,2012,10.1371/journal.pone.0042969,https://pubmed.ncbi.nlm.nih.gov/23028439/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,21046216,Pleiotropic effects of DCDC2 and DYX1C1 genes on language and mathematics traits in nuclear families of developmental dyslexia.,2011,10.1007/s10519-010-9412-7,https://pubmed.ncbi.nlm.nih.gov/21046216/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,29601588,ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms.,2018,10.1371/journal.pgen.1007316,https://pubmed.ncbi.nlm.nih.gov/29601588/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,22326444,Neocortical disruption and behavioral impairments in rats following in utero RNAi of candidate dyslexia risk gene Kiaa0319.,2012,10.1016/j.ijdevneu.2012.01.009,https://pubmed.ncbi.nlm.nih.gov/22326444/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,17259020,Developmental disruptions and behavioral impairments in rats following in utero RNAi of Dyx1c1.,2007,10.1016/j.brainresbull.2006.11.005,https://pubmed.ncbi.nlm.nih.gov/17259020/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,15249932,Support for EKN1 as the susceptibility locus for dyslexia on 15q21.,2004,10.1038/sj.mp.4001543,https://pubmed.ncbi.nlm.nih.gov/15249932/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,27307695,Serum molecular signature for proliferative diabetic retinopathy in Saudi patients with type 2 diabetes.,2016,,https://pubmed.ncbi.nlm.nih.gov/27307695/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF4,ENSG00000256061,Unsafe,12954984,A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain.,2003,10.1073/pnas.1833911100,https://pubmed.ncbi.nlm.nih.gov/12954984/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,41480157,Case Report: Minigene assays reveal a novel &lt;i&gt;DNAAF6&lt;/i&gt; intronic variant as the key etiology for primary ciliary dyskinesia.,2025,10.3389/fgene.2025.1692658,https://pubmed.ncbi.nlm.nih.gov/41480157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,38991708,A range of 30-62% of functioning multiciliated airway cells is sufficient to maintain ciliary airway clearance.,2024,10.1183/13993003.01441-2023,https://pubmed.ncbi.nlm.nih.gov/38991708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,41516134,NSUN7 Regulates Sperm Flagella Formation at All Stages of Spermiogenesis.,2025,10.3390/ijms27010257,https://pubmed.ncbi.nlm.nih.gov/41516134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,37900281,PIH1D3-knockout rats exhibit full ciliopathy features and dysfunctional pre-assembly and loading of dynein arms in motile cilia.,2023,10.3389/fcell.2023.1282787,https://pubmed.ncbi.nlm.nih.gov/37900281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,35873488,Strongly Truncated Dnaaf4 Plays a Conserved Role in Drosophila Ciliary Dynein Assembly as Part of an R2TP-Like Co-Chaperone Complex With Dnaaf6.,2022,10.3389/fgene.2022.943197,https://pubmed.ncbi.nlm.nih.gov/35873488/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,38762183,The binding of LARP6 and DNAAF6 in biomolecular condensates influences ciliogenesis of multiciliated cells.,2024,10.1016/j.jbc.2024.107373,https://pubmed.ncbi.nlm.nih.gov/38762183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,41264116,The essential role of cytoskeleton and ciliary abnormalities in the development of congenital pulmonary airway malformations.,2025,10.1007/s00383-025-06250-0,https://pubmed.ncbi.nlm.nih.gov/41264116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,38408845,Skewed X-chromosome inactivation drives the proportion of &lt;i&gt;DNAAF6&lt;/i&gt;-defective airway motile cilia and variable expressivity in primary ciliary dyskinesia.,2024,10.1136/jmg-2023-109700,https://pubmed.ncbi.nlm.nih.gov/38408845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,40947900,Lentiviral Gene Delivery Rescues Ciliary Defects in Patient-Derived Airway Organoids from Primary Ciliary Dyskinesia.,2025,10.1177/10430342251378128,https://pubmed.ncbi.nlm.nih.gov/40947900/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,33106461,Novel deletion mutations of the PIH1D3 gene in an infertile young man with primary ciliary dyskinesia and his cousin with Kartagener's syndrome.,2021,10.4103/aja.aja_43_20,https://pubmed.ncbi.nlm.nih.gov/33106461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,32170493,Novel DNAAF6 variants identified by whole-exome sequencing cause male infertility and primary ciliary dyskinesia.,2020,10.1007/s10815-020-01735-4,https://pubmed.ncbi.nlm.nih.gov/32170493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,33635866,Defects in the cytoplasmic assembly of axonemal dynein arms cause morphological abnormalities and dysmotility in sperm cells leading to male infertility.,2021,10.1371/journal.pgen.1009306,https://pubmed.ncbi.nlm.nih.gov/33635866/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,34145793,Methylation of three genes encoded by X chromosome in blood leukocytes and colorectal cancer risk.,2021,10.1002/cam4.4056,https://pubmed.ncbi.nlm.nih.gov/34145793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,32820521,[Analysis of PIH1D3 variant in a Chinese pedigree affected with primary ciliary dyskinesia].,2020,10.3760/cma.j.cn511374-20190722-00361,https://pubmed.ncbi.nlm.nih.gov/32820521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,36159986,Subtyping children with asthma by clustering analysis of mRNA expression data.,2022,10.3389/fgene.2022.974936,https://pubmed.ncbi.nlm.nih.gov/36159986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,28176794,X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3.,2017,10.1038/ncomms14279,https://pubmed.ncbi.nlm.nih.gov/28176794/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,24421334,Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm.,2014,10.1083/jcb.201304076,https://pubmed.ncbi.nlm.nih.gov/24421334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,33488680,Transcriptome Analyses Identify an RNA Binding Protein Related Prognostic Model for Clear Cell Renal Cell Carcinoma.,2020,10.3389/fgene.2020.617872,https://pubmed.ncbi.nlm.nih.gov/33488680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,28041644,Mutations in PIH1D3 Cause X-Linked Primary Ciliary Dyskinesia with Outer and Inner Dynein Arm Defects.,2017,10.1016/j.ajhg.2016.11.019,https://pubmed.ncbi.nlm.nih.gov/28041644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,29363216,Diagnostic yield of a targeted gene panel in primary ciliary dyskinesia patients.,2018,10.1002/humu.23403,https://pubmed.ncbi.nlm.nih.gov/29363216/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF6,ENSG00000080572,Unsafe,12601173,Immunomic analysis of human sarcoma.,2003,10.1073/pnas.0437972100,https://pubmed.ncbi.nlm.nih.gov/12601173/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF8,ENSG00000166246,Unsafe,33263282,Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins.,2020,10.7554/elife.58662,https://pubmed.ncbi.nlm.nih.gov/33263282/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF8,ENSG00000166246,Unsafe,35333908,Disc and Actin Associated Protein 1 influences attachment in the intestinal parasite Giardia lamblia.,2022,10.1371/journal.ppat.1010433,https://pubmed.ncbi.nlm.nih.gov/35333908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAAF8,ENSG00000166246,Unsafe,30009705,Synergistic Interplay of The Co-administration of Rifampin And Newly Developed Anti-TB Drug: Could It Be a Promising New Line of TB Therapy?,2018,10.2174/1386207321666180716093617,https://pubmed.ncbi.nlm.nih.gov/30009705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,40898283,DNAH10 mutation cause primary ciliary dyskinesia with defects of IDAf complex assembly and lung fibrosis manifestation.,2025,10.1186/s13023-025-03977-w,https://pubmed.ncbi.nlm.nih.gov/40898283/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,42083518,DNAI4 is required for flagellum assembly and male fertility in mice.,2026,10.1242/dev.205190,https://pubmed.ncbi.nlm.nih.gov/42083518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,39996363,Novel bi-allelic variants in DNAH10 lead to multiple morphological abnormalities of sperm flagella and male infertility.,2025,10.4103/aja2024116,https://pubmed.ncbi.nlm.nih.gov/39996363/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,41751132,Single- and Multi-Trait Genome-Wide Association Analyses Identify the Genetic Loci and Candidate Genes for Growth Traits in &lt;i&gt;Plecoglossus altivelis&lt;/i&gt;.,2026,10.3390/ani16040670,https://pubmed.ncbi.nlm.nih.gov/41751132/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,37314648,Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice.,2023,10.1007/s11684-023-0988-8,https://pubmed.ncbi.nlm.nih.gov/37314648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,40376536,Establishment and clinical significance of genetic factor screening method for patients with nonobstructive azoospermia based on whole exon sequencing technology.,2025,10.21037/tau-2024-676,https://pubmed.ncbi.nlm.nih.gov/40376536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,34657236,Bi-allelic variants in DNAH10 cause asthenoteratozoospermia and male infertility.,2022,10.1007/s10815-021-02306-x,https://pubmed.ncbi.nlm.nih.gov/34657236/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,34237282,Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice.,2021,10.1016/j.ajhg.2021.06.010,https://pubmed.ncbi.nlm.nih.gov/34237282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,36792588,DNALI1 deficiency causes male infertility with severe asthenozoospermia in humans and mice by disrupting the assembly of the flagellar inner dynein arms and fibrous sheath.,2023,10.1038/s41419-023-05653-y,https://pubmed.ncbi.nlm.nih.gov/36792588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,41001426,Stratification by Mutational Landscape Reveals Differential Immune Infiltration and Predicts the Recurrence and Clinical Outcome of Cervical Cancer.,2025,10.1007/s43657-024-00158-w,https://pubmed.ncbi.nlm.nih.gov/41001426/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,36881978,Comparative transcriptome analysis identified crucial genes and pathways affecting sperm motility in the reproductive tract of drakes with different libido.,2023,10.1016/j.psj.2023.102560,https://pubmed.ncbi.nlm.nih.gov/36881978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,39270811,Identification of competing endogenous RNA networks associated with circRNA and lncRNA in TCDD-induced cleft palate development.,2024,10.1016/j.toxlet.2024.09.001,https://pubmed.ncbi.nlm.nih.gov/39270811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,31836722,Discovery of increased epidermal DNAH10 expression after regeneration of dermis in a randomized with-in person trial - reflections on psoriatic inflammation.,2019,10.1038/s41598-019-53874-z,https://pubmed.ncbi.nlm.nih.gov/31836722/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,39523437,Novel variants in DNAH9 are present in two infertile patients with severe asthenospermia.,2025,10.1038/s10038-024-01304-y,https://pubmed.ncbi.nlm.nih.gov/39523437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,34915022,The axonemal dynein heavy chain 10 gene is essential for monocilia motility and spine alignment in zebrafish.,2022,10.1016/j.ydbio.2021.12.001,https://pubmed.ncbi.nlm.nih.gov/34915022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,31959735,DNAH10 mutation correlates with cisplatin sensitivity and tumor mutation burden in small-cell lung cancer.,2020,10.18632/aging.102683,https://pubmed.ncbi.nlm.nih.gov/31959735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,32128068,Identification of rare variants in novel candidate genes in pulmonary atresia patients by next generation sequencing.,2020,10.1016/j.csbj.2020.01.011,https://pubmed.ncbi.nlm.nih.gov/32128068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,35812163,FUS-P525L Juvenile Amyotrophic Lateral Sclerosis and Intellectual Disability: Evidence for Association and Oligogenic Inheritance.,2022,10.1212/nxg.0000000000200009,https://pubmed.ncbi.nlm.nih.gov/35812163/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,29843777,Rare copy number variants analysis identifies novel candidate genes in heterotaxy syndrome patients with congenital heart defects.,2018,10.1186/s13073-018-0549-y,https://pubmed.ncbi.nlm.nih.gov/29843777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,26517670,"Variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A are associated with intermediate Charcot-Marie-Tooth disease in a Norwegian family.",2016,10.1111/ane.12515,https://pubmed.ncbi.nlm.nih.gov/26517670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,35301265,A general framework for identifying oligogenic combinations of rare variants in complex disorders.,2022,10.1101/gr.276348.121,https://pubmed.ncbi.nlm.nih.gov/35301265/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,34791246,Whole-exome sequencing of a cohort of infertile men reveals novel causative genes in teratozoospermia that are chiefly related to sperm head defects.,2021,10.1093/humrep/deab229,https://pubmed.ncbi.nlm.nih.gov/34791246/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,30778226,Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.,2019,10.1038/s41588-018-0334-2,https://pubmed.ncbi.nlm.nih.gov/30778226/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,27841877,Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.,2017,10.1038/ng.3714,https://pubmed.ncbi.nlm.nih.gov/27841877/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH10,ENSG00000197653,Unsafe,19936222,"Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.",2009,10.1371/journal.pgen.1000730,https://pubmed.ncbi.nlm.nih.gov/19936222/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,42323797,The potential role of dynein heavy chain genes in the pathophysiology of undescended testis.,2026,10.1007/s00383-026-06506-3,https://pubmed.ncbi.nlm.nih.gov/42323797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,41430008,DNAH11 impairs memory via disrupted synaptic plasticity in noise-induced hidden hearing loss mice.,2025,10.1007/s10565-025-10124-5,https://pubmed.ncbi.nlm.nih.gov/41430008/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,42317261,Case report: novel &lt;i&gt;DNAH11&lt;/i&gt; compound heterozygous variants including an exon 30-54 duplication in a child with a highly suggestive primary ciliary dyskinesia phenotype.,2026,10.3389/fgene.2026.1857794,https://pubmed.ncbi.nlm.nih.gov/42317261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,42102130,Variants in the DNAH11 gene responsible for primary ciliary dyskinesia or probably atypical primary ciliary dyskinesia presenting left-right asymmetry disorder.,2026,10.1371/journal.pone.0348352,https://pubmed.ncbi.nlm.nih.gov/42102130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,41818315,Molecular and immunological heterogeneity of eosinophilic esophagitis: Insights and subtyping.,2026,10.1371/journal.pone.0342834,https://pubmed.ncbi.nlm.nih.gov/41818315/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,41398886,Biallelic variants in DNAH11 cause male infertility with asthenozoospermia in a Chinese non-consanguineous family: A case report.,2025,10.1097/md.0000000000046556,https://pubmed.ncbi.nlm.nih.gov/41398886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,40351391,Biallelic &lt;i&gt;DNAH11&lt;/i&gt; Variations Cause Male Infertility with Multiple Morphological Abnormalities of the Sperm Flagellum in Humans.,2025,10.1002/mco2.70210,https://pubmed.ncbi.nlm.nih.gov/40351391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,42072084,Transcriptomic Analysis of Fermented Chinese Chive Selectively Attenuating Deoxynivalenol-Induced Ovarian Toxicity in Mice.,2026,10.3390/antiox15040442,https://pubmed.ncbi.nlm.nih.gov/42072084/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,41720779,Genetic modifiers of APOE-ε4-associated cognitive decline.,2026,10.1038/s41467-026-68933-z,https://pubmed.ncbi.nlm.nih.gov/41720779/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,40118907,Genome wide interaction study of genetic variants associated with lung function decline.,2025,10.1038/s41598-025-93147-6,https://pubmed.ncbi.nlm.nih.gov/40118907/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,41264116,The essential role of cytoskeleton and ciliary abnormalities in the development of congenital pulmonary airway malformations.,2025,10.1007/s00383-025-06250-0,https://pubmed.ncbi.nlm.nih.gov/41264116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,39256880,Association of novel DNAH11 variants with asthenoteratozoospermia lead to male infertility.,2024,10.1186/s40246-024-00658-w,https://pubmed.ncbi.nlm.nih.gov/39256880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,42134984,Nasal nitric oxide combined with clinical features for preliminary screening of primary ciliary dyskinesia in bronchiectasis.,2026,10.1183/13993003.02796-2025,https://pubmed.ncbi.nlm.nih.gov/42134984/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,41584385,Situs Inversus Totalis: A Case Report and Literature Review.,2026,10.1002/ccr3.71941,https://pubmed.ncbi.nlm.nih.gov/41584385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,41373829,Heterogeneity of Primary Ciliary Dyskinesia Gene Variants: A Genetic Database Analysis in Russia.,2025,10.3390/ijms262311674,https://pubmed.ncbi.nlm.nih.gov/41373829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,41645376,[Analysis of DNAH11 gene variants and clinical characteristics of a Chinese pedigree affected with Primary ciliary dyskinesia].,2025,10.3760/cma.j.cn511374-20250724-00450,https://pubmed.ncbi.nlm.nih.gov/41645376/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,38970307,Impact of genomic and epigenomic alterations of multigene on a multicancer pedigree.,2024,10.1002/cam4.7394,https://pubmed.ncbi.nlm.nih.gov/38970307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,40399499,"Genome-Wide Association Study of Age-Related Hearing Loss in CFW Mice Identifies Multiple Genes and Loci, Including Prkag2.",2025,10.1007/s10162-025-00994-1,https://pubmed.ncbi.nlm.nih.gov/40399499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,40371404,Primary ciliary dyskinesia: a case report of double DNAH11 mutant alleles.,2025,10.15386/mpr-2743,https://pubmed.ncbi.nlm.nih.gov/40371404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,41267578,Prevalence and Nationality Distribution of Known and Novel Genetic Variants in Children With Primary Ciliary Dyskinesia in the State of Qatar.,2026,10.1111/cge.70112,https://pubmed.ncbi.nlm.nih.gov/41267578/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,39447114,Long-Term Lung Function and &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; Infection in Genotyped Primary Ciliary Dyskinesia.,2025,10.1513/annalsats.202404-340oc,https://pubmed.ncbi.nlm.nih.gov/39447114/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,36548460,Identification of Cell Types and Transcriptome Landscapes of Porcine Epidemic Diarrhea Virus-Infected Porcine Small Intestine Using Single-Cell RNA Sequencing.,2023,10.4049/jimmunol.2101216,https://pubmed.ncbi.nlm.nih.gov/36548460/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,39115449,Whole genome sequencing enhances molecular diagnosis of primary ciliary dyskinesia.,2024,10.1002/ppul.27200,https://pubmed.ncbi.nlm.nih.gov/39115449/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,37488248,Transmission disequilibrium analysis of whole genome data in childhood-onset systemic lupus erythematosus.,2023,10.1038/s41435-023-00214-x,https://pubmed.ncbi.nlm.nih.gov/37488248/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,33714943,Mucin 4 mutation is associated with tumor mutation burden and promotes antitumor immunity in colon cancer patients.,2021,10.18632/aging.202756,https://pubmed.ncbi.nlm.nih.gov/33714943/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,34453042,Whole exome and transcriptome sequencing reveal clonal evolution and exhibit immune-related features in metastatic colorectal tumors.,2021,10.1038/s41420-021-00607-9,https://pubmed.ncbi.nlm.nih.gov/34453042/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,31949857,"The association between the DNAH11 rs10248618 SNP and serum lipid traits, the risk of coronary artery disease, and ischemic stroke.",2018,,https://pubmed.ncbi.nlm.nih.gov/31949857/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,31966465,"DNAH11 rs12670798 variant and G × E interactions on serum lipid levels, coronary heart disease, ischemic stroke and the lipid-lowering efficacy of atorvastatin.",2017,,https://pubmed.ncbi.nlm.nih.gov/31966465/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,38962571,Infertility and pregnancy outcomes among adults with primary ciliary dyskinesia.,2024,10.1093/hropen/hoae039,https://pubmed.ncbi.nlm.nih.gov/38962571/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,35854386,Clinical and genetic spectrum of primary ciliary dyskinesia in Chinese patients: a systematic review.,2022,10.1186/s13023-022-02427-1,https://pubmed.ncbi.nlm.nih.gov/35854386/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,30349421,Somatic mutations in renal cell carcinomas from Chinese patients revealed by whole exome sequencing.,2018,10.1186/s12935-018-0661-5,https://pubmed.ncbi.nlm.nih.gov/30349421/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,29510755,Whole exome sequencing in three families segregating a pediatric case of sarcoidosis.,2018,10.1186/s12920-018-0338-x,https://pubmed.ncbi.nlm.nih.gov/29510755/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,29691636,Genome-wide association for testis weight in the diversity outbred mouse population.,2018,10.1007/s00335-018-9745-8,https://pubmed.ncbi.nlm.nih.gov/29691636/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,29851510,Quantifying Ciliary Dynamics during Assembly Reveals Stepwise Waveform Maturation in Airway Cells.,2018,10.1165/rcmb.2017-0436oc,https://pubmed.ncbi.nlm.nih.gov/29851510/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,32636717,The plasma peptides of sepsis.,2020,10.1186/s12014-020-09288-5,https://pubmed.ncbi.nlm.nih.gov/32636717/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,33139725,CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module.,2020,10.1038/s41467-020-19113-0,https://pubmed.ncbi.nlm.nih.gov/33139725/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH11,ENSG00000105877,Unsafe,31178125,"Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.",2019,10.1016/j.ajhg.2019.04.015,https://pubmed.ncbi.nlm.nih.gov/31178125/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,41596228,Biallelic Truncating DNAH14 Variant in Siblings with Neurodevelopmental Disorder and Predominant Ataxia: Clinical Report and Literature Review.,2026,10.3390/ijms27020575,https://pubmed.ncbi.nlm.nih.gov/41596228/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,41686705,DNAH14 deficiency disrupts sperm annulus positioning and compromises offspring postnatal development.,2026,10.1093/humrep/deag014,https://pubmed.ncbi.nlm.nih.gov/41686705/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,42563519,Systematic Reanalysis of Whole-Exome Sequencing in Genetically Unsolved Pediatric Primary Ciliary Dyskinesia.,2026,10.1002/ppul.71776,https://pubmed.ncbi.nlm.nih.gov/42563519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,41214581,Multi-omics data-based modeling reveals tumorigenesis- and prognosis-associated genes with clinical potential in lung adenocarcinoma.,2025,10.1186/s12885-025-14943-x,https://pubmed.ncbi.nlm.nih.gov/41214581/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,39564730,"Blood Plasma Methylated DNA Markers in the Detection of Lymphoma: Discovery, Validation, and Clinical Pilot.",2025,10.1002/ajh.27533,https://pubmed.ncbi.nlm.nih.gov/39564730/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,38263208,Circular RNA DNAH14 molecular mechanism in an experimental model of hepatocellular carcinoma treated with Cobalt chloride to mimic the hypoxia-like response of transcatheter arterial chemoembolization.,2024,10.1038/s41598-024-52578-3,https://pubmed.ncbi.nlm.nih.gov/38263208/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,34604037,Machine Learning-Based Comparative Analysis of Pan-Cancer and Pan-Normal Tissues Identifies Pan-Cancer Tissue-Enriched circRNAs Related to Cancer Mutations as Potential Exosomal Biomarkers.,2021,10.3389/fonc.2021.703461,https://pubmed.ncbi.nlm.nih.gov/34604037/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,36344539,"The diagnostic yield, candidate genes, and pitfalls for a genetic study of intellectual disability in 118 middle eastern families.",2022,10.1038/s41598-022-22036-z,https://pubmed.ncbi.nlm.nih.gov/36344539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,38447012,Targeted DNA sequencing of high-grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene expression.,2024,10.1002/ijc.34908,https://pubmed.ncbi.nlm.nih.gov/38447012/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,33577779,Clinical and Genetic Spectrum of Children With Primary Ciliary Dyskinesia in China.,2021,10.1016/j.chest.2021.02.006,https://pubmed.ncbi.nlm.nih.gov/33577779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,30206710,Genetic variations using whole-exome sequencing might predict response for neoadjuvant chemoradiotherapy in locally advanced rectal cancer.,2018,10.1007/s12032-018-1202-8,https://pubmed.ncbi.nlm.nih.gov/30206710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,32848021,Exome sequencing of 112 trios identifies recessive genetic variants in brain arteriovenous malformations.,2021,10.1136/neurintsurg-2020-016469,https://pubmed.ncbi.nlm.nih.gov/32848021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,29323929,Variation in Cilia Protein Genes and Progression of Lung Disease in Cystic Fibrosis.,2018,10.1513/annalsats.201706-451oc,https://pubmed.ncbi.nlm.nih.gov/29323929/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,31096545,Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia.,2019,10.3390/ijms20102394,https://pubmed.ncbi.nlm.nih.gov/31096545/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,29764119,Founder Mutations for Early Onset Melanoma as Revealed by Whole Exome Sequencing Suggests That This is Not Associated with the Increasing Incidence of Melanoma in Poland.,2019,10.4143/crt.2018.157,https://pubmed.ncbi.nlm.nih.gov/29764119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,26636390,Panventriculomegaly with a wide foramen of Magendie and large cisterna magna.,2016,10.3171/2015.6.jns15162,https://pubmed.ncbi.nlm.nih.gov/26636390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,28339086,Identification of novel mutations in endometrial cancer patients by whole-exome sequencing.,2017,10.3892/ijo.2017.3919,https://pubmed.ncbi.nlm.nih.gov/28339086/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,26036949,Identification of embryonic lethal genes in humans by autozygosity mapping and exome sequencing in consanguineous families.,2015,10.1186/s13059-015-0681-6,https://pubmed.ncbi.nlm.nih.gov/26036949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH14,ENSG00000185842,Unsafe,23555554,Discovery analysis of TCGA data reveals association between germline genotype and survival in ovarian cancer patients.,2013,10.1371/journal.pone.0055037,https://pubmed.ncbi.nlm.nih.gov/23555554/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,42323797,The potential role of dynein heavy chain genes in the pathophysiology of undescended testis.,2026,10.1007/s00383-026-06506-3,https://pubmed.ncbi.nlm.nih.gov/42323797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,41863311,A clinical protocol for the detection of comorbidities associated with monogenic causes of male infertility.,2026,10.1093/humrep/deag038,https://pubmed.ncbi.nlm.nih.gov/41863311/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,42597842,&lt;i&gt;HIPK4&lt;/i&gt; is a novel gene associated with teratozoospermia and male infertility.,2026,10.1093/hropen/hoag066,https://pubmed.ncbi.nlm.nih.gov/42597842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,41809782,Homozygous &lt;i&gt;Myo7A&lt;/i&gt; mutation associations teratozoospermia and intracytoplasmic sperm injection failure in humans and mice.,2026,10.21037/tau-2025-474,https://pubmed.ncbi.nlm.nih.gov/41809782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,41549443,Novel homozygous or compound heterozygous DNAH17 variants lead to male infertility characterized by multiple morphological abnormalities of the sperm flagella and asthenoteratozoospermia in humans.,2026,10.4103/aja202567,https://pubmed.ncbi.nlm.nih.gov/41549443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,41437299,Reproductive physiological impacts of high ambient temperature on animals: the impaired testicular function and compromised sperm quality in C57BL/6 mice.,2025,10.1186/s40659-025-00662-x,https://pubmed.ncbi.nlm.nih.gov/41437299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,41453584,Genome-wide association and transcriptome studies identify candidate genes regulating perirenal fat deposition in sheep.,2026,10.1016/j.ygeno.2025.111182,https://pubmed.ncbi.nlm.nih.gov/41453584/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,39261362,LncRNA DNAH17-AS1 promotes gastric cancer proliferation and radioresistance by sponging miR-202-3p to upregulate ONECUT2.,2024,10.1007/s12672-024-01297-2,https://pubmed.ncbi.nlm.nih.gov/39261362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,40694934,Gonadal sex differentiation in Eleutheronema tetradactylum: Histological features and transcriptomic insights from mature gonads.,2025,10.1016/j.cbd.2025.101586,https://pubmed.ncbi.nlm.nih.gov/40694934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,41115892,Identifying potential genetic biomarkers for sperm dysfunction through whole-genome sequencing.,2025,10.1038/s41598-025-23897-w,https://pubmed.ncbi.nlm.nih.gov/41115892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,40009974,Novel variants in DNAH17 cause sperm flagellar outer dynein arm defects but not total fertilization failure after ICSI.,2025,10.1016/j.rbmo.2024.104492,https://pubmed.ncbi.nlm.nih.gov/40009974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,37933082,Expression of cAMP and oxidative phosphorylation-related lncRNAs in non-functioning pituitary adenomas.,2023,10.1111/jcmm.18011,https://pubmed.ncbi.nlm.nih.gov/37933082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,40376536,Establishment and clinical significance of genetic factor screening method for patients with nonobstructive azoospermia based on whole exon sequencing technology.,2025,10.21037/tau-2024-676,https://pubmed.ncbi.nlm.nih.gov/40376536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,37574497,Novel mutations in DNAH17 cause sperm flagellum defects and their influence on ICSI outcome.,2023,10.1007/s10815-023-02897-7,https://pubmed.ncbi.nlm.nih.gov/37574497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,39245651,Homozygous CCDC146 mutation causes oligoasthenoteratozoospermia in humans and mice.,2024,10.24272/j.issn.2095-8137.2024.019,https://pubmed.ncbi.nlm.nih.gov/39245651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,38858421,A natural loss-of-function deletion of the cytohesin 1 (Cyth1) gene in BALB/cByJ mice does not impact cardiomyocyte polyploidy.,2024,10.1038/s41598-024-63667-8,https://pubmed.ncbi.nlm.nih.gov/38858421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,39362423,Retrotransposon involves in photoperiodic spermatogenesis in Brandt's voles (Lasiopodomys brandtii) by co-transcription with flagellar genes.,2024,10.1016/j.ijbiomac.2024.136224,https://pubmed.ncbi.nlm.nih.gov/39362423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,40810911,Biallelic loss-of-function variants of DNAH7 cause male infertility associated with asthenozoospermia in humans.,2025,10.1007/s00439-025-02766-6,https://pubmed.ncbi.nlm.nih.gov/40810911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,39267058,Whole exome sequencing analysis of 167 men with primary infertility.,2024,10.1186/s12920-024-02005-3,https://pubmed.ncbi.nlm.nih.gov/39267058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,41463217,Synolitic Graph Neural Networks of High-Dimensional Proteomic Data Enhance Early Detection of Ovarian Cancer.,2025,10.3390/cancers17243972,https://pubmed.ncbi.nlm.nih.gov/41463217/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,37584493,Designing of neoepitopes based vaccine against breast cancer using integrated immuno and bioinformatics approach.,2024,10.1080/07391102.2023.2247081,https://pubmed.ncbi.nlm.nih.gov/37584493/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,40936780,Antisense RNAs (asRNAs) as key players in gallbladder cancer progression: a bioinformatics analysis.,2025,10.22037/ghfbb.v18i2.3002,https://pubmed.ncbi.nlm.nih.gov/40936780/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,37001189,Microcystin leucine arginine induces human sperm damage: Involvement of the Ca2+/CaMKKβ/AMPK pathway.,2023,10.1016/j.ecoenv.2023.114845,https://pubmed.ncbi.nlm.nih.gov/37001189/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,37624511,Senescence-associated secretory phenotype constructed detrimental and beneficial subtypes and prognostic index for prostate cancer patients undergoing radical prostatectomy.,2023,10.1007/s12672-023-00777-1,https://pubmed.ncbi.nlm.nih.gov/37624511/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,38511217,Systematic molecular analyses for 115 karyotypically normal men with isolated non-obstructive azoospermia.,2024,10.1093/humrep/deae057,https://pubmed.ncbi.nlm.nih.gov/38511217/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,33959500,Genomic Alteration Characterization in Colorectal Cancer Identifies a Prognostic and Metastasis Biomarker: FAM83A|IDO1.,2021,10.3389/fonc.2021.632430,https://pubmed.ncbi.nlm.nih.gov/33959500/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,35082514,Identification of Potential Biological Factors Affecting the Treatment of Ticagrelor After Percutaneous Coronary Intervention in the Chinese Population.,2022,10.2147/pgpm.s338287,https://pubmed.ncbi.nlm.nih.gov/35082514/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,34700279,Whole-exome sequencing identifies biosignatures that predict adverse survival outcomes in surgically treated patients with oral cavity squamous cell carcinoma.,2021,10.1016/j.oraloncology.2021.105547,https://pubmed.ncbi.nlm.nih.gov/34700279/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,30721949,Mutational landscape of T-cell lymphoma in mice lacking the DNA mismatch repair gene Mlh1: no synergism with ionizing radiation.,2019,10.1093/carcin/bgz013,https://pubmed.ncbi.nlm.nih.gov/30721949/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,14639620,Humoral immune response against melanoma antigens induced by vaccination with cytokine gene-modified autologous tumor cells.,2004,10.1002/ijc.11537,https://pubmed.ncbi.nlm.nih.gov/14639620/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,31178125,"Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.",2019,10.1016/j.ajhg.2019.04.015,https://pubmed.ncbi.nlm.nih.gov/31178125/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH17,ENSG00000187775,Unsafe,9545504,A potential human axonemal dynein heavy-chain gene maps to 17q25.,1998,10.1007/s003359900782,https://pubmed.ncbi.nlm.nih.gov/9545504/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,42180707,A homozygous splice-site variant in &lt;i&gt;ZMYND10&lt;/i&gt; causes primary ciliary dyskinesia with primary infertility in a Chinese family.,2026,10.3389/fmed.2026.1838497,https://pubmed.ncbi.nlm.nih.gov/42180707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,40406060,Identification of candidate genes harboring pathogenic variants in congenital heart disease and laterality defects in Chinese population.,2025,10.3389/fgene.2025.1582718,https://pubmed.ncbi.nlm.nih.gov/40406060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,41300775,Endometrial Signatures of Subfertility in Beef Heifers Reveal Dysregulation of MAPK Signaling and Ciliary Function.,2025,10.3390/genes16111323,https://pubmed.ncbi.nlm.nih.gov/41300775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,41115892,Identifying potential genetic biomarkers for sperm dysfunction through whole-genome sequencing.,2025,10.1038/s41598-025-23897-w,https://pubmed.ncbi.nlm.nih.gov/41115892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,38570187,Genetic mutation of &lt;i&gt;Cep76&lt;/i&gt; results in male infertility due to abnormal sperm tail composition.,2024,10.26508/lsa.202302452,https://pubmed.ncbi.nlm.nih.gov/38570187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,40376536,Establishment and clinical significance of genetic factor screening method for patients with nonobstructive azoospermia based on whole exon sequencing technology.,2025,10.21037/tau-2024-676,https://pubmed.ncbi.nlm.nih.gov/40376536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,40412113,"Prepubertal exposure to 17β-estradiol downregulates motor protein genes, impairs sperm flagella formation, and reduces fertility in Nile tilapia (Oreochromis niloticus).",2025,10.1016/j.aquatox.2025.107422,https://pubmed.ncbi.nlm.nih.gov/40412113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,39362423,Retrotransposon involves in photoperiodic spermatogenesis in Brandt's voles (Lasiopodomys brandtii) by co-transcription with flagellar genes.,2024,10.1016/j.ijbiomac.2024.136224,https://pubmed.ncbi.nlm.nih.gov/39362423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,33968937,Genetic Defects in DNAH2 Underlie Male Infertility With Multiple Morphological Abnormalities of the Sperm Flagella in Humans and Mice.,2021,10.3389/fcell.2021.662903,https://pubmed.ncbi.nlm.nih.gov/33968937/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,38884051,Unraveling the Genetic Basis of Combined Deafness and Male Infertility Phenotypes through High-Throughput Sequencing in a Unique Cohort from South India.,2024,10.1002/ggn2.202300206,https://pubmed.ncbi.nlm.nih.gov/38884051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,40910240,Comparing Ovarian Clear Cell Carcinoma and High-Grade Serous Carcinoma Based on the SEER Database and Analyzing the Significantly Mutated Genes.,2025,10.2174/0115680096370568250806153217,https://pubmed.ncbi.nlm.nih.gov/40910240/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,34604380,Molecular Profiling of Spermatozoa Reveals Correlations between Morphology and Gene Expression: A Novel Biomarker Panel for Male Infertility.,2021,10.1155/2021/1434546,https://pubmed.ncbi.nlm.nih.gov/34604380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,40269853,Genetic and transcriptional insights into immune checkpoint blockade response and survival: lessons from melanoma and beyond.,2025,10.1186/s12967-025-06467-6,https://pubmed.ncbi.nlm.nih.gov/40269853/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,32251302,Transcriptomic analysis of female and male gonads in juvenile snakeskin gourami (Trichopodus pectoralis).,2020,10.1038/s41598-020-61738-0,https://pubmed.ncbi.nlm.nih.gov/32251302/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,33771466,Novel bi-allelic variants in DNAH2 cause severe asthenoteratozoospermia with multiple morphological abnormalities of the flagella.,2021,10.1016/j.rbmo.2021.01.011,https://pubmed.ncbi.nlm.nih.gov/33771466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,35402838,DNAH2 facilitates the homologous recombination repair of Fanconi anemia pathway through modulating FANCD2 ubiquitination.,2021,10.1097/bs9.0000000000000076,https://pubmed.ncbi.nlm.nih.gov/35402838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,34237282,Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice.,2021,10.1016/j.ajhg.2021.06.010,https://pubmed.ncbi.nlm.nih.gov/34237282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,35449766,Novel Compound Heterozygous Variants in CCDC40 Associated with Primary Ciliary Dyskinesia and Multiple Morphological Abnormalities of the Sperm Flagella.,2022,10.2147/pgpm.s359821,https://pubmed.ncbi.nlm.nih.gov/35449766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,30060180,Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat.,2019,10.1093/jmcb/mjy043,https://pubmed.ncbi.nlm.nih.gov/30060180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,33428592,Identification of candidate genes encoding tumor-specific neoantigens in early- and late-stage colon adenocarcinoma.,2021,10.18632/aging.202370,https://pubmed.ncbi.nlm.nih.gov/33428592/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,38511217,Systematic molecular analyses for 115 karyotypically normal men with isolated non-obstructive azoospermia.,2024,10.1093/humrep/deae057,https://pubmed.ncbi.nlm.nih.gov/38511217/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,34791246,Whole-exome sequencing of a cohort of infertile men reveals novel causative genes in teratozoospermia that are chiefly related to sperm head defects.,2021,10.1093/humrep/deab229,https://pubmed.ncbi.nlm.nih.gov/34791246/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,31178125,"Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.",2019,10.1016/j.ajhg.2019.04.015,https://pubmed.ncbi.nlm.nih.gov/31178125/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH2,ENSG00000183914,Unsafe,9256245,"Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.",1997,10.1016/s0014-5793(97)00800-4,https://pubmed.ncbi.nlm.nih.gov/9256245/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,42323797,The potential role of dynein heavy chain genes in the pathophysiology of undescended testis.,2026,10.1007/s00383-026-06506-3,https://pubmed.ncbi.nlm.nih.gov/42323797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,42321501,Structural and functional characterization of DNAH5 variants in a Portuguese family with primary ciliary dyskinesia.,2026,10.1007/s10815-026-03930-1,https://pubmed.ncbi.nlm.nih.gov/42321501/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,42274615,Functional Characterization of a Novel Homozygous &lt;i&gt;DNAH5&lt;/i&gt; Single-Nucleotide Intronic Deletion in a Consanguineous Portuguese Family with Primary Ciliary Dyskinesia.,2026,10.3390/cells15111022,https://pubmed.ncbi.nlm.nih.gov/42274615/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,41561107,Mucociliary and cough clearance in primary ciliary dyskinesia as affected by mutations in &lt;i&gt;RSPH1&lt;/i&gt; or &lt;i&gt;DNAH5&lt;/i&gt;.,2026,10.1183/23120541.00681-2025,https://pubmed.ncbi.nlm.nih.gov/41561107/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,41983364,A Compound Heterozygous Missense Variant in The &lt;i&gt;DNAH5&lt;/i&gt; Gene Could Be A Significant Factor in Unexplained Male Infertility: A Case Study.,2026,10.22074/ijfs.2025.2051131.1811,https://pubmed.ncbi.nlm.nih.gov/41983364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,42511910,Screening of a Novel Synonymous &lt;i&gt;DNAH5&lt;/i&gt; Variant in Histopathologically Confirmed Adenomyosis Cases from Turkiye.,2026,10.3390/biomedicines14071435,https://pubmed.ncbi.nlm.nih.gov/42511910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,41948467,Two Distinct Clinical Presentations of Primary Ciliary Dyskinesia (PCD): Diagnostic Utility of Whole-Exome Sequencing in a Genetically Heterogeneous Disorder.,2026,10.2147/tacg.s549665,https://pubmed.ncbi.nlm.nih.gov/41948467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,40558543,Molecular Insights into Outer Dynein Arm Defects in Primary Ciliary Dyskinesia: Involvement of ZMYND10 and GRP78.,2025,10.3390/cells14120916,https://pubmed.ncbi.nlm.nih.gov/40558543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,42180707,A homozygous splice-site variant in &lt;i&gt;ZMYND10&lt;/i&gt; causes primary ciliary dyskinesia with primary infertility in a Chinese family.,2026,10.3389/fmed.2026.1838497,https://pubmed.ncbi.nlm.nih.gov/42180707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,39594631,"Loss of &lt;i&gt;Dnah5&lt;/i&gt; Downregulates &lt;i&gt;Dync1h1&lt;/i&gt; Expression, Causing Cortical Development Disorders and Congenital Hydrocephalus.",2024,10.3390/cells13221882,https://pubmed.ncbi.nlm.nih.gov/39594631/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,41680104,Concurrent mutations in &lt;i&gt;DNAH5&lt;/i&gt; and &lt;i&gt;FOXE3&lt;/i&gt; genes: a unique occurrence in infancy.,2026,10.5115/acb.25.317,https://pubmed.ncbi.nlm.nih.gov/41680104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,42326386,Exploration of candidate genes associated with rare SNVs in pulmonary stenosis using whole-exome sequencing and machine learning.,2026,10.3389/fgene.2026.1765512,https://pubmed.ncbi.nlm.nih.gov/42326386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,41049813,Two &lt;i&gt;DNAH5&lt;/i&gt; mutations in a Kartagener syndrome patient with azoospermia.,2025,10.1016/j.ajur.2025.04.001,https://pubmed.ncbi.nlm.nih.gov/41049813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,42490099,"Anisometropia and Its Related Traits: Ocular, Systemic, and Genetic Characteristics-Results From the Gutenberg Health Study.",2026,10.1167/iovs.67.8.50,https://pubmed.ncbi.nlm.nih.gov/42490099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,40746421,Proteomic and structural comparison between cilia from primary ciliary dyskinesia patients with a DNAH5 defect.,2025,10.3389/fmolb.2025.1593810,https://pubmed.ncbi.nlm.nih.gov/40746421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,41064994,Characterisation of a primary ciliary dyskinesia model generated from BMI1-transduced basal epithelial cells.,2025,10.1242/jcs.263886,https://pubmed.ncbi.nlm.nih.gov/41064994/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,40591047,Identification of key biomarkers and potential therapeutic drugs in nasopharyngeal carcinoma based on comprehensive bioinformatics analysis.,2025,10.1007/s12672-025-03047-4,https://pubmed.ncbi.nlm.nih.gov/40591047/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,42325438,Novel pathogenic variant in &lt;i&gt;ARMC4&lt;/i&gt; identified by whole exome sequencing in a Turkish family with primary ciliary dyskinesia.,2026,10.3389/fmolb.2026.1815627,https://pubmed.ncbi.nlm.nih.gov/42325438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,42072084,Transcriptomic Analysis of Fermented Chinese Chive Selectively Attenuating Deoxynivalenol-Induced Ovarian Toxicity in Mice.,2026,10.3390/antiox15040442,https://pubmed.ncbi.nlm.nih.gov/42072084/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,40182617,Empowering limited-resource countries: collaborating with expert centers for diagnosis of primary ciliary dyskinesia.,2025,10.3389/fmolb.2025.1547152,https://pubmed.ncbi.nlm.nih.gov/40182617/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,42542301,LncDNAH5 Regulates Radiation Therapy-Induced Toxicity via MDM2-Mediated Degradation of TP53BP1.,2026,10.1016/j.ijrobp.2026.07.020,https://pubmed.ncbi.nlm.nih.gov/42542301/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,40688712,Pneumonia and bacteremia due to &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; in a primary ciliary dyskinesia patient with &lt;i&gt;DNAH5&lt;/i&gt; variants: A case report.,2025,10.1016/j.rmcr.2025.102259,https://pubmed.ncbi.nlm.nih.gov/40688712/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,39543663,Machine learning-driven estimation of mutational burden highlights DNAH5 as a prognostic marker in colorectal cancer.,2024,10.1186/s13062-024-00564-0,https://pubmed.ncbi.nlm.nih.gov/39543663/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,40781753,Radiomics-based prediction of T cell-inflamed gene expression profile and prognosis in head and neck squamous cell carcinoma. ,2025,10.1002/mp.18028,https://pubmed.ncbi.nlm.nih.gov/40781753/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,38022557,Identification and validation of a prognostic-related mutant gene DNAH5 for hepatocellular carcinoma.,2023,10.3389/fimmu.2023.1236995,https://pubmed.ncbi.nlm.nih.gov/38022557/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,39761349,Region-specific roles of oviductal motile cilia in oocyte/embryo transport and fertility†.,2025,10.1093/biolre/ioaf005,https://pubmed.ncbi.nlm.nih.gov/39761349/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,40666282,Comparative transcriptome profiling of the lumbosacral dorsal root ganglia reveals sexually dimorphic gene expression in a murine model of coronavirus-induced neurodegeneration.,2025,10.62347/slke7419,https://pubmed.ncbi.nlm.nih.gov/40666282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,34616010,Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients.,2022,10.1038/s41416-021-01557-w,https://pubmed.ncbi.nlm.nih.gov/34616010/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,36118901,Bioinformatics searching of diagnostic markers and immune infiltration in polycystic ovary syndrome.,2022,10.3389/fgene.2022.937309,https://pubmed.ncbi.nlm.nih.gov/36118901/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,39115449,Whole genome sequencing enhances molecular diagnosis of primary ciliary dyskinesia.,2024,10.1002/ppul.27200,https://pubmed.ncbi.nlm.nih.gov/39115449/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,35869121,Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness.,2022,10.1038/s41598-022-16488-6,https://pubmed.ncbi.nlm.nih.gov/35869121/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,38364346,Diesel exhaust particle exposure exacerbates ciliary and epithelial barrier dysfunction in the multiciliated bronchial epithelium models.,2024,10.1016/j.ecoenv.2024.116090,https://pubmed.ncbi.nlm.nih.gov/38364346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,34391405,Novel compound heterozygous mutations of DNAH5 identified in a pediatric patient with Kartagener syndrome: case report and literature review.,2021,10.1186/s12890-021-01586-4,https://pubmed.ncbi.nlm.nih.gov/34391405/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,34746153,Titin Mutation Is Associated With Tumor Mutation Burden and Promotes Antitumor Immunity in Lung Squamous Cell Carcinoma.,2021,10.3389/fcell.2021.761758,https://pubmed.ncbi.nlm.nih.gov/34746153/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,32664073,Two mutations in the axonemal dynein heavy chain gene 5 in a Chinese asthenozoospermia patient: A case report.,2020,10.1097/md.0000000000020813,https://pubmed.ncbi.nlm.nih.gov/32664073/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH5,ENSG00000039139,Unsafe,31178125,"Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.",2019,10.1016/j.ajhg.2019.04.015,https://pubmed.ncbi.nlm.nih.gov/31178125/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,42172611,Protective effects of metformin and vitamin C on diabetes-induced testicular dysfunction.,2026,10.1093/reprod/xaag064,https://pubmed.ncbi.nlm.nih.gov/42172611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,42479727,Establishment and characterization of three canine ameloblastoma cell lines with genomic and transcriptomic profiles.,2026,10.1371/journal.pone.0353197,https://pubmed.ncbi.nlm.nih.gov/42479727/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,40810911,Biallelic loss-of-function variants of DNAH7 cause male infertility associated with asthenozoospermia in humans.,2025,10.1007/s00439-025-02766-6,https://pubmed.ncbi.nlm.nih.gov/40810911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,40694934,Gonadal sex differentiation in Eleutheronema tetradactylum: Histological features and transcriptomic insights from mature gonads.,2025,10.1016/j.cbd.2025.101586,https://pubmed.ncbi.nlm.nih.gov/40694934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,42278275,Molecular Mimicry by the Tick-Borne Encephalitis Virus E Protein: A Hidden Link to Autoimmunity.,2026,10.3390/ijms27114745,https://pubmed.ncbi.nlm.nih.gov/42278275/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,40145662,A cross-tissue transcriptome-wide association study reveals novel susceptibility genes for erectile dysfunction.,2026,10.1111/andr.70034,https://pubmed.ncbi.nlm.nih.gov/40145662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,41115892,Identifying potential genetic biomarkers for sperm dysfunction through whole-genome sequencing.,2025,10.1038/s41598-025-23897-w,https://pubmed.ncbi.nlm.nih.gov/41115892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,40412113,"Prepubertal exposure to 17β-estradiol downregulates motor protein genes, impairs sperm flagella formation, and reduces fertility in Nile tilapia (Oreochromis niloticus).",2025,10.1016/j.aquatox.2025.107422,https://pubmed.ncbi.nlm.nih.gov/40412113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,39849482,IQUB mutation induces radial spoke 1 deficiency causing asthenozoospermia with normal sperm morphology in humans and mice.,2025,10.1186/s12964-025-02043-z,https://pubmed.ncbi.nlm.nih.gov/39849482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,39634417,Novel bioinformatic approaches show the role of driver genes in the progression of cervical cancer: An in-silico study.,2024,10.1016/j.heliyon.2024.e40179,https://pubmed.ncbi.nlm.nih.gov/39634417/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,39056782,"Primary Ciliary Dyskinesia Associated Disease-Causing Variants in &lt;i&gt;CCDC39&lt;/i&gt; and &lt;i&gt;CCDC40&lt;/i&gt; Cause Axonemal Absence of Inner Dynein Arm Heavy Chains DNAH1, DNAH6, and DNAH7.",2024,10.3390/cells13141200,https://pubmed.ncbi.nlm.nih.gov/39056782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,36660654,DNAH7 mutations benefit colorectal cancer patients receiving immune checkpoint inhibitors.,2022,10.21037/atm-22-6166,https://pubmed.ncbi.nlm.nih.gov/36660654/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,39267058,Whole exome sequencing analysis of 167 men with primary infertility.,2024,10.1186/s12920-024-02005-3,https://pubmed.ncbi.nlm.nih.gov/39267058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,36792588,DNALI1 deficiency causes male infertility with severe asthenozoospermia in humans and mice by disrupting the assembly of the flagellar inner dynein arms and fibrous sheath.,2023,10.1038/s41419-023-05653-y,https://pubmed.ncbi.nlm.nih.gov/36792588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,36881978,Comparative transcriptome analysis identified crucial genes and pathways affecting sperm motility in the reproductive tract of drakes with different libido.,2023,10.1016/j.psj.2023.102560,https://pubmed.ncbi.nlm.nih.gov/36881978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,38046281,"Recombinant Human Adenovirus Type 5 (H101) Intra-Tumor Therapy in Patients with Persistent, Recurrent, or Metastatic Cervical Cancer: Genomic Profiling Relating to Clinical Efficacy.",2023,10.2147/dddt.s429180,https://pubmed.ncbi.nlm.nih.gov/38046281/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,37998386,Ciliary Ultrastructure Assessed by Transmission Electron Microscopy in Adults with Bronchiectasis and Suspected Primary Ciliary Dyskinesia but Inconclusive Genotype.,2023,10.3390/cells12222651,https://pubmed.ncbi.nlm.nih.gov/37998386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,35543642,Loss of function mutation in DNAH7 induces male infertility associated with abnormalities of the sperm flagella and mitochondria in human.,2022,10.1111/cge.14146,https://pubmed.ncbi.nlm.nih.gov/35543642/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,32976492,Deficiency of the Tbc1d21 gene causes male infertility with morphological abnormalities of the sperm mitochondria and flagellum in mice.,2020,10.1371/journal.pgen.1009020,https://pubmed.ncbi.nlm.nih.gov/32976492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,34476482,Bi-allelic mutations in DNAH7 cause asthenozoospermia by impairing the integrality of axoneme structure.,2021,10.1093/abbs/gmab113,https://pubmed.ncbi.nlm.nih.gov/34476482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,37415451,COVID-19 progression towards ARDS: a genome wide study reveals host factors underlying critical COVID-19.,2023,10.5808/gi.22080,https://pubmed.ncbi.nlm.nih.gov/37415451/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,34070971,Innate and Adaptive Immune Genes Associated with MERS-CoV Infection in Dromedaries.,2021,10.3390/cells10061291,https://pubmed.ncbi.nlm.nih.gov/34070971/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,32735892,Network perturbation analysis in human bronchial epithelial cells following SARS-CoV2 infection.,2020,10.1016/j.yexcr.2020.112204,https://pubmed.ncbi.nlm.nih.gov/32735892/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,11877439,Identification of dynein heavy chain 7 as an inner arm component of human cilia that is synthesized but not assembled in a case of primary ciliary dyskinesia.,2002,10.1074/jbc.m200348200,https://pubmed.ncbi.nlm.nih.gov/11877439/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH7,ENSG00000118997,Unsafe,11175280,"Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes.",2000,10.1038/sj.ejhg.5200555,https://pubmed.ncbi.nlm.nih.gov/11175280/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,42323797,The potential role of dynein heavy chain genes in the pathophysiology of undescended testis.,2026,10.1007/s00383-026-06506-3,https://pubmed.ncbi.nlm.nih.gov/42323797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,41858859,"CAPZA1 deficiency disrupts sperm flagellar structure and motility, potentially involving the p300/SLC7A11 pathway.",2026,10.3389/fendo.2026.1744836,https://pubmed.ncbi.nlm.nih.gov/41858859/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,42260890,Pediatric primary ciliary dyskinesia with rare genetic variants: Synonymous RSPH4A and potential NFE2L2 modifier of DNAH9 phenotype - 2-case report.,2026,10.1097/md.0000000000049153,https://pubmed.ncbi.nlm.nih.gov/42260890/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,41335398,Pachymic Acid Promotes ILC2 Migration to the Brain via Dynein Axonemal Heavy Chain 9 Upregulation.,2025,10.1007/s12035-025-05482-4,https://pubmed.ncbi.nlm.nih.gov/41335398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,42630107,"Genetics in Heterotaxy: A Case Series and Literature Review on DNAH9, PKD1L1, MMP21, and GDF1.",2026,10.1111/cge.70227,https://pubmed.ncbi.nlm.nih.gov/42630107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,40376972,Novel compound heterozygous mutation in &lt;i&gt;DNAH9&lt;/i&gt; causes complex congenital heart disease.,2025,10.3892/mmr.2025.13563,https://pubmed.ncbi.nlm.nih.gov/40376972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,41948467,Two Distinct Clinical Presentations of Primary Ciliary Dyskinesia (PCD): Diagnostic Utility of Whole-Exome Sequencing in a Genetically Heterogeneous Disorder.,2026,10.2147/tacg.s549665,https://pubmed.ncbi.nlm.nih.gov/41948467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,40065384,DNAH9 variants in children with post-infectious bronchiolitis/bronchitis obliterans.,2025,10.1186/s13023-025-03616-4,https://pubmed.ncbi.nlm.nih.gov/40065384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,42865680,Rare missense variants identified by whole-genome sequencing in men with oligoasthenoteratozoospermia: An experimental study.,2026,10.18502/ijrm.v24i8.21663,https://pubmed.ncbi.nlm.nih.gov/42865680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,39523437,Novel variants in DNAH9 are present in two infertile patients with severe asthenospermia.,2025,10.1038/s10038-024-01304-y,https://pubmed.ncbi.nlm.nih.gov/39523437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,40984650,Elevated N6-Methyladenosine (m6A)-RNA-Methylation During Oral Carcinogenesis.,2026,10.1111/jop.70066,https://pubmed.ncbi.nlm.nih.gov/40984650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,35729109,Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening.,2022,10.1038/s41419-022-05010-5,https://pubmed.ncbi.nlm.nih.gov/35729109/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,39267058,Whole exome sequencing analysis of 167 men with primary infertility.,2024,10.1186/s12920-024-02005-3,https://pubmed.ncbi.nlm.nih.gov/39267058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,40122115,Integrated bioinformatics analysis identifies neutrophils and villous cytotrophoblasts infiltration characterized by BLC6 upregulation as associated with the co-occurrence of gestational diabetes mellitus and pre-eclampsia.,2025,10.1080/10641955.2025.2475814,https://pubmed.ncbi.nlm.nih.gov/40122115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,37168556,Whole-exome sequencing study of hypospadias.,2023,10.1016/j.isci.2023.106663,https://pubmed.ncbi.nlm.nih.gov/37168556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,41872334,Obesity-associated gene mutations across cancer types: a pan-cancer analysis of TCGA data.,2026,10.1038/s44276-026-00214-0,https://pubmed.ncbi.nlm.nih.gov/41872334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,38884051,Unraveling the Genetic Basis of Combined Deafness and Male Infertility Phenotypes through High-Throughput Sequencing in a Unique Cohort from South India.,2024,10.1002/ggn2.202300206,https://pubmed.ncbi.nlm.nih.gov/38884051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,37168331,Identification of hub genes associated with head and neck squamous cell carcinoma by integrated bioinformatics approach and RNA-seq validation analysis.,2023,,https://pubmed.ncbi.nlm.nih.gov/37168331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,33610189,Novel variants in DNAH9 lead to nonsyndromic severe asthenozoospermia.,2021,10.1186/s12958-021-00709-0,https://pubmed.ncbi.nlm.nih.gov/33610189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,35853630,Epigenome-wide DNA methylation study of whole blood in patients with sporadic amyotrophic lateral sclerosis.,2022,10.1097/cm9.0000000000002090,https://pubmed.ncbi.nlm.nih.gov/35853630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,40269853,Genetic and transcriptional insights into immune checkpoint blockade response and survival: lessons from melanoma and beyond.,2025,10.1186/s12967-025-06467-6,https://pubmed.ncbi.nlm.nih.gov/40269853/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,37193176,"A necroptosis gene signature predicts prostate cancer recurrence, and is linked to somatic mutation, therapeutic landscape, and immune infiltration.",2023,,https://pubmed.ncbi.nlm.nih.gov/37193176/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,38938903,Dynein axonemal heavy chain 9 M4374I variation may have an effect on imatinib mesylate resistance in CML.,2022,10.3892/mi.2022.29,https://pubmed.ncbi.nlm.nih.gov/38938903/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,36712782,A Novel DNAH9 Gene Mutation Causing Primary Ciliary Dyskinesia With an Unusual Association of Jejunal Atresia in a Bahraini Child.,2022,10.7759/cureus.32964,https://pubmed.ncbi.nlm.nih.gov/36712782/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,38277230,Identification of molecular characteristics of FUT8 and alteration of core fucosylation in kidney renal clear cell cancer.,2024,10.18632/aging.205482,https://pubmed.ncbi.nlm.nih.gov/38277230/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,37196196,Gene signature developed for predicting early relapse and survival in early-stage pancreatic cancer.,2023,10.1093/bjsopen/zrad031,https://pubmed.ncbi.nlm.nih.gov/37196196/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,37942473,Integrative Analysis of Single-Cell and Bulk RNA Sequencing Reveals Prognostic Characteristics of Macrophage Polarization-Related Genes in Lung Adenocarcinoma.,2023,10.2147/ijgm.s430408,https://pubmed.ncbi.nlm.nih.gov/37942473/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,36027483,"Updated Overall Survival and Exploratory Analysis From Randomized, Phase II EVAN Study of Erlotinib Versus Vinorelbine Plus Cisplatin Adjuvant Therapy in Stage IIIA Epidermal Growth Factor Receptor+ Non-Small-Cell Lung Cancer.",2022,10.1200/jco.22.00428,https://pubmed.ncbi.nlm.nih.gov/36027483/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,36265913,Genetic diagnosis for adult patients at a genetic clinic.,2022,10.1101/mcs.a006235,https://pubmed.ncbi.nlm.nih.gov/36265913/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,36451444,Network module function enrichment analysis of lung squamous cell carcinoma and lung adenocarcinoma.,2022,10.1097/md.0000000000031798,https://pubmed.ncbi.nlm.nih.gov/36451444/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,33933816,"High-throughput, sliding-window algorithm for assessing chemical complementarity between immune receptor CDR3 domains and cancer mutant peptides: TRG-PIK3CA interactions and breast cancer.",2021,10.1016/j.molimm.2021.02.026,https://pubmed.ncbi.nlm.nih.gov/33933816/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,37100790,Single-cell transcriptomes reveal heterogeneity of chlorine-induced mice acute lung injury and the inhibitory effect of pentoxifylline on ferroptosis.,2023,10.1038/s41598-023-32093-7,https://pubmed.ncbi.nlm.nih.gov/37100790/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,35719192,miR-149-3p Is a Potential Prognosis Biomarker and Correlated with Immune Infiltrates in Uterine Corpus Endometrial Carcinoma.,2022,10.1155/2022/5006123,https://pubmed.ncbi.nlm.nih.gov/35719192/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,34482403,Identification and prioritization of myeloid malignancy germline variants in a large cohort of adult patients with AML.,2022,10.1182/blood.2021011354,https://pubmed.ncbi.nlm.nih.gov/34482403/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,32098966,The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants.,2020,10.1038/s41467-020-14829-5,https://pubmed.ncbi.nlm.nih.gov/32098966/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,26822197,Frequent variations in cancer-related genes may play prognostic role in treatment of patients with chronic myeloid leukemia.,2016,10.1186/s12863-015-0308-7,https://pubmed.ncbi.nlm.nih.gov/26822197/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,29851510,Quantifying Ciliary Dynamics during Assembly Reveals Stepwise Waveform Maturation in Airway Cells.,2018,10.1165/rcmb.2017-0436oc,https://pubmed.ncbi.nlm.nih.gov/29851510/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,25751026,Quantitative optical coherence tomography imaging of intermediate flow defect phenotypes in ciliary physiology and pathophysiology.,2015,10.1117/1.jbo.20.3.030502,https://pubmed.ncbi.nlm.nih.gov/25751026/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,31178125,"Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.",2019,10.1016/j.ajhg.2019.04.015,https://pubmed.ncbi.nlm.nih.gov/31178125/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAH9,ENSG00000007174,Unsafe,30471717,Mutations in Outer Dynein Arm Heavy Chain DNAH9 Cause Motile Cilia Defects and Situs Inversus.,2018,10.1016/j.ajhg.2018.10.016,https://pubmed.ncbi.nlm.nih.gov/30471717/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI4,ENSG00000152763,Unsafe,42083518,DNAI4 is required for flagellum assembly and male fertility in mice.,2026,10.1242/dev.205190,https://pubmed.ncbi.nlm.nih.gov/42083518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI4,ENSG00000152763,Unsafe,39827215,TCTEX1D2 is essential for sperm flagellum formation in mice.,2025,10.1038/s41598-024-83424-1,https://pubmed.ncbi.nlm.nih.gov/39827215/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI4,ENSG00000152763,Unsafe,41566712,Comparative genomics reveals evolutionary signatures of genes associated with jumping in beetles.,2026,10.24272/j.issn.2095-8137.2025.319,https://pubmed.ncbi.nlm.nih.gov/41566712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI4,ENSG00000152763,Unsafe,38247231,Tanreqing suppresses the proliferation and migration of non-small cell lung cancer cells by mediating the inactivation of the HIF1α signaling pathway via exosomal circ-WDR78.,2025,10.1080/07391102.2023.2301514,https://pubmed.ncbi.nlm.nih.gov/38247231/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI4,ENSG00000152763,Unsafe,34782613,Bi-allelic variants in human WDR63 cause male infertility via abnormal inner dynein arms assembly.,2021,10.1038/s41421-021-00327-5,https://pubmed.ncbi.nlm.nih.gov/34782613/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI4,ENSG00000152763,Unsafe,39170352,Construction and validation of a ubiquitination-related prognostic risk score signature in breast cancer.,2024,10.1016/j.heliyon.2024.e35553,https://pubmed.ncbi.nlm.nih.gov/39170352/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI4,ENSG00000152763,Unsafe,30060180,Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat.,2019,10.1093/jmcb/mjy043,https://pubmed.ncbi.nlm.nih.gov/30060180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI4,ENSG00000152763,Unsafe,33247464,Distinct circular RNA expression profiles in pediatric ependymomas.,2021,10.1111/bpa.12922,https://pubmed.ncbi.nlm.nih.gov/33247464/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI4,ENSG00000152763,Unsafe,38898815,Development and Validation of a Prognostic Model based on 11 E3-related Genes for Colon Cancer Patients.,2024,10.2174/0113816128292398240306160051,https://pubmed.ncbi.nlm.nih.gov/38898815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI4,ENSG00000152763,Unsafe,35965538,Microarray and bioinformatic analysis reveal the parental genes of m6A modified circRNAs as novel prognostic signatures in colorectal cancer.,2022,10.3389/fonc.2022.939790,https://pubmed.ncbi.nlm.nih.gov/35965538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI4,ENSG00000152763,Unsafe,33378017,Molecular insights into the development of hepatic metastases in colorectal cancer: a metastasis prediction study.,2020,10.26355/eurrev_202012_24168,https://pubmed.ncbi.nlm.nih.gov/33378017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI4,ENSG00000152763,Unsafe,32721119,Tumorigenic effects of TLX overexpression in HEK 293T cells.,2019,10.1002/cnr2.1204,https://pubmed.ncbi.nlm.nih.gov/32721119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI4,ENSG00000152763,Unsafe,32651235,Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.,2021,10.1136/gutjnl-2019-319706,https://pubmed.ncbi.nlm.nih.gov/32651235/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI4,ENSG00000152763,Unsafe,25663627,Temporal endogenous gene expression profiles in response to polymer-mediated transfection and profile comparison to lipid-mediated transfection.,2015,10.1002/jgm.2822,https://pubmed.ncbi.nlm.nih.gov/25663627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,35836922,CASC1 Expression in Bladder Cancer Is Regulated by Exosomal miRNA-150: A Comprehensive Pan-Cancer and Bioinformatics Study.,2022,10.1155/2022/8100325,https://pubmed.ncbi.nlm.nih.gov/35836922/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,38094437,Retracted: CASC1 Expression in Bladder Cancer Is Regulated by Exosomal miRNA-150: A Comprehensive Pan-Cancer and Bioinformatics Study.,2023,10.1155/2023/9867274,https://pubmed.ncbi.nlm.nih.gov/38094437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,38180340,Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery.,2024,10.7554/elife.86847,https://pubmed.ncbi.nlm.nih.gov/38180340/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,39287372,Histone deacetylase HDAC3 regulates ergosterol production for oxidative stress tolerance in the entomopathogenic and endophytic fungus &lt;i&gt;Metarhizium robertsii&lt;/i&gt;.,2024,10.1128/msystems.00953-24,https://pubmed.ncbi.nlm.nih.gov/39287372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,36796466,Covalent targeting the LAS1-NOL9 axis for selective treatment in NPM1 mutant acute myeloid leukemia.,2023,10.1016/j.phrs.2023.106700,https://pubmed.ncbi.nlm.nih.gov/36796466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,41636297,Retraction Note.,2026,10.26355/eurrev_202601_37643,https://pubmed.ncbi.nlm.nih.gov/41636297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,32712772,Disruption of a Rice Chloroplast-Targeted Gene OsHMBPP Causes a Seedling-Lethal Albino Phenotype.,2020,10.1186/s12284-020-00408-1,https://pubmed.ncbi.nlm.nih.gov/32712772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,37921038,Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.,2023,10.15252/embr.202357984,https://pubmed.ncbi.nlm.nih.gov/37921038/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,32220933,It takes two (Las1 HEPN endoribonuclease domains) to cut RNA correctly.,2020,10.1074/jbc.ra119.011193,https://pubmed.ncbi.nlm.nih.gov/32220933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,37542054,A multi-omics analysis identifies molecular features associated with fertility in heifers (Bos taurus).,2023,10.1038/s41598-023-39858-0,https://pubmed.ncbi.nlm.nih.gov/37542054/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,33664239,Inhibiting β-catenin disables nucleolar functions in triple-negative breast cancer.,2021,10.1038/s41419-021-03531-z,https://pubmed.ncbi.nlm.nih.gov/33664239/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,28652339,Grc3 programs the essential endoribonuclease Las1 for specific RNA cleavage.,2017,10.1073/pnas.1703133114,https://pubmed.ncbi.nlm.nih.gov/28652339/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,28929238,Nuclease integrated kinase super assemblies (NiKs) and their role in RNA processing.,2018,10.1007/s00294-017-0749-9,https://pubmed.ncbi.nlm.nih.gov/28929238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,30556886,GAS5 promotes myocardial apoptosis in myocardial ischemia-reperfusion injury via upregulating LAS1 expression.,2018,10.26355/eurrev_201812_16544,https://pubmed.ncbi.nlm.nih.gov/30556886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,29459759,Genomics of a pediatric ovarian fibrosarcoma. Association with the DICER1 syndrome.,2018,10.1038/s41598-018-21663-9,https://pubmed.ncbi.nlm.nih.gov/29459759/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,29440475,Characterization of the molecular crosstalk within the essential Grc3/Las1 pre-rRNA processing complex.,2018,10.1261/rna.065037.117,https://pubmed.ncbi.nlm.nih.gov/29440475/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,24860162,Mechanisms promoting escape from mitotic stress-induced tumor cell death.,2014,10.1158/0008-5472.can-13-3398,https://pubmed.ncbi.nlm.nih.gov/24860162/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,25343375,Plant oxidosqualene metabolism: cycloartenol synthase-dependent sterol biosynthesis in Nicotiana benthamiana.,2014,10.1371/journal.pone.0109156,https://pubmed.ncbi.nlm.nih.gov/25343375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,31488907,Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex.,2019,10.1038/s41594-019-0289-8,https://pubmed.ncbi.nlm.nih.gov/31488907/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,23175604,Las1 interacts with Grc3 polynucleotide kinase and is required for ribosome synthesis in Saccharomyces cerevisiae.,2013,10.1093/nar/gks1086,https://pubmed.ncbi.nlm.nih.gov/23175604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAI7,ENSG00000118307,Unsafe,23768067,"Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing.",2013,10.1186/1745-6150-8-15,https://pubmed.ncbi.nlm.nih.gov/23768067/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,41413469,"DNAJB13 polymorphisms and association with idiopathic asthenozoospermia in Sichuan, China.",2025,10.1186/s12610-025-00295-w,https://pubmed.ncbi.nlm.nih.gov/41413469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,41807802,Normal Fertility of Dnajb13 (exon2 KO)/(exon2 c.106T &gt; C Mut) Compound Heterozygous Mutant Male Mice.,2026,10.1007/s43032-026-02065-z,https://pubmed.ncbi.nlm.nih.gov/41807802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,41800303,"The effects of polysaccharides from &lt;i&gt;Inonotus obliquus&lt;/i&gt;, artemisinin, and dihydroartemisinin on the reproductive system of male mice infected with Neospora caninum.",2026,10.3389/fvets.2026.1740054,https://pubmed.ncbi.nlm.nih.gov/41800303/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,42049738,Small heat shock and J-domain proteins direct defense against areca palm velarivirus 1 by degrading coat protein via autophagy.,2026,10.1038/s41467-026-72498-2,https://pubmed.ncbi.nlm.nih.gov/42049738/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,41115892,Identifying potential genetic biomarkers for sperm dysfunction through whole-genome sequencing.,2025,10.1038/s41598-025-23897-w,https://pubmed.ncbi.nlm.nih.gov/41115892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,40146200,Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice.,2025,10.7554/elife.100350,https://pubmed.ncbi.nlm.nih.gov/40146200/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,38928079,The Role of Z Chromosome Localization Gene psmd9 in Spermatogenesis of Cynoglossus semilaevis.,2024,10.3390/ijms25126372,https://pubmed.ncbi.nlm.nih.gov/38928079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,39849482,IQUB mutation induces radial spoke 1 deficiency causing asthenozoospermia with normal sperm morphology in humans and mice.,2025,10.1186/s12964-025-02043-z,https://pubmed.ncbi.nlm.nih.gov/39849482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,40232348,German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway.,2025,10.1007/s11357-025-01640-7,https://pubmed.ncbi.nlm.nih.gov/40232348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,35166991,A novel homozygous mutation in DNAJB13-a gene associated with the sperm axoneme-leads to teratozoospermia.,2022,10.1007/s10815-022-02431-1,https://pubmed.ncbi.nlm.nih.gov/35166991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,33346962,[Expression of Dnajb13 and its involvement in the apoptosis of spermatogenic cells in the testis of the mouse with cryptorchidism].,2020,,https://pubmed.ncbi.nlm.nih.gov/33346962/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,39099656,Immune infiltration and prognosis in gastric cancer: role of NAD+ metabolism-related markers.,2024,10.7717/peerj.17833,https://pubmed.ncbi.nlm.nih.gov/39099656/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,31342671,Missense mutation in DNAJB13 gene correlated with male fertility in asthenozoospermia.,2020,10.1111/andr.12685,https://pubmed.ncbi.nlm.nih.gov/31342671/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,36555213,Targeted Methylation Profiling of Single Laser-Capture Microdissected Post-Mortem Brain Cells by Adapted Limiting Dilution Bisulfite Pyrosequencing (LDBSP).,2022,10.3390/ijms232415571,https://pubmed.ncbi.nlm.nih.gov/36555213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,27486783,"Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility.",2016,10.1016/j.ajhg.2016.06.022,https://pubmed.ncbi.nlm.nih.gov/27486783/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,30697164,Transcriptomic Analysis Reveals Insights on Male Infertility in Octopus maya Under Chronic Thermal Stress.,2018,10.3389/fphys.2018.01920,https://pubmed.ncbi.nlm.nih.gov/30697164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,25233908,"DNAJB13, a type II HSP40 family member, localizes to the spermatids and spermatozoa during mouse spermatogenesis.",2014,10.1186/s12861-014-0038-5,https://pubmed.ncbi.nlm.nih.gov/25233908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,27998865,[Interaction of DNAJB13 with HK1 in mouse].,2016,,https://pubmed.ncbi.nlm.nih.gov/27998865/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,33116619,Gene Expression Along with Genomic Copy Number Variation and Mutational Analysis Were Used to Develop a 9-Gene Signature for Estimating Prognosis of COAD.,2020,10.2147/ott.s255590,https://pubmed.ncbi.nlm.nih.gov/33116619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,29298896,Mechanistic insights into acephalic spermatozoa syndrome-associated mutations in the human SUN5 gene.,2018,10.1074/jbc.ra117.000861,https://pubmed.ncbi.nlm.nih.gov/29298896/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,33596828,Genome-wide identification and functional prediction of long non-coding RNAs in Sprague-Dawley rats during heat stress.,2021,10.1186/s12864-021-07421-8,https://pubmed.ncbi.nlm.nih.gov/33596828/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJB13,ENSG00000187726,Unsafe,18227282,Dimeric heat shock protein 40 binds radial spokes for generating coupled power strokes and recovery strokes of 9 + 2 flagella.,2008,10.1083/jcb.200705069,https://pubmed.ncbi.nlm.nih.gov/18227282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC24,ENSG00000170946,Unsafe,40713574,DNAJC24 suppresses breast cancer malignancy and serves as a prognostic biomarker.,2025,10.1186/s12935-025-03918-4,https://pubmed.ncbi.nlm.nih.gov/40713574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC24,ENSG00000170946,Unsafe,39281955,Arabidopsis Dph4 is an Hsp70 Cochaperone with Iron-Binding Properties.,2024,10.1021/acsomega.4c01776,https://pubmed.ncbi.nlm.nih.gov/39281955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC24,ENSG00000170946,Unsafe,38713100,DNAJC24 acts directly with PCNA and promotes malignant progression of LUAD by activating phosphorylation of AKT.,2024,10.1096/fj.202300667rr,https://pubmed.ncbi.nlm.nih.gov/38713100/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC24,ENSG00000170946,Unsafe,35606363,DNAJC24 is a potential therapeutic target in hepatocellular carcinoma through affecting ammonia metabolism.,2022,10.1038/s41419-022-04953-z,https://pubmed.ncbi.nlm.nih.gov/35606363/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC24,ENSG00000170946,Unsafe,37918133,Screening of reliable reference genes for the normalization of RT-qPCR in chicken gastrointestinal tract.,2023,10.1016/j.psj.2023.103169,https://pubmed.ncbi.nlm.nih.gov/37918133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC24,ENSG00000170946,Unsafe,40301754,A genome-wide association study identified candidate genes associated with egg quality traits in Muscovy duck.,2025,10.1186/s12864-025-11503-2,https://pubmed.ncbi.nlm.nih.gov/40301754/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC24,ENSG00000170946,Unsafe,35715682,Genetic Analysis of HSP40/DNAJ Family Genes in Parkinson's Disease: a Large Case-Control Study.,2022,10.1007/s12035-022-02920-5,https://pubmed.ncbi.nlm.nih.gov/35715682/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC24,ENSG00000170946,Unsafe,31566424,Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion.,2019,10.1152/ajprenal.00195.2019,https://pubmed.ncbi.nlm.nih.gov/31566424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC24,ENSG00000170946,Unsafe,22367199,"Structure and mechanistic insights into novel iron-mediated moonlighting functions of human J-protein cochaperone, Dph4.",2012,10.1074/jbc.m112.339655,https://pubmed.ncbi.nlm.nih.gov/22367199/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC24,ENSG00000170946,Unsafe,30572005,Deletion distal to the PAX6 coding region reveals a novel basis for familial cosegregation of aniridia and diabetes mellitus.,2019,10.1016/j.diabres.2018.12.002,https://pubmed.ncbi.nlm.nih.gov/30572005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC24,ENSG00000170946,Unsafe,22509046,Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy.,2012,10.1073/pnas.1204523109,https://pubmed.ncbi.nlm.nih.gov/22509046/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC24,ENSG00000170946,Unsafe,21321669,A 556 kb deletion in the downstream region of the PAX6 gene causes familial aniridia and other eye anomalies in a Chinese family.,2011,,https://pubmed.ncbi.nlm.nih.gov/21321669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC24,ENSG00000170946,Unsafe,26261303,Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor.,2015,10.1073/pnas.1512863112,https://pubmed.ncbi.nlm.nih.gov/26261303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC24,ENSG00000170946,Unsafe,18765564,Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development.,2008,10.1242/jcs.035550,https://pubmed.ncbi.nlm.nih.gov/18765564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC24,ENSG00000170946,Unsafe,26419218,A familial pericentric inversion of chromosome 11 associated with a microdeletion of 163 kb and microduplication of 288 kb at 11p13 and 11q22.3 without aniridia or eye anomalies.,2016,10.1002/ajmg.a.37388,https://pubmed.ncbi.nlm.nih.gov/26419218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC24,ENSG00000170946,Unsafe,16572726,A genomewide analysis of genes for the heat shock protein 70 chaperone system in the ascidian Ciona intestinalis.,2006,10.1379/csc-137r.1,https://pubmed.ncbi.nlm.nih.gov/16572726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC24,ENSG00000170946,Unsafe,34705337,Establishment of a pig CRISPR/Cas9 knockout library for functional gene screening in pig cells.,2022,10.1002/biot.202100408,https://pubmed.ncbi.nlm.nih.gov/34705337/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC24,ENSG00000170946,Unsafe,33451274,A 1.6 Mb region on SSC2 is associated with antibody response to classical swine fever vaccination in a mixed pig population.,2022,10.1080/10495398.2021.1873145,https://pubmed.ncbi.nlm.nih.gov/33451274/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC28,ENSG00000177692,Unsafe,41632590,Comparative genomic and evolutionary analysis of the heat shock protein gene family in the chicken genome.,2026,10.1080/10495398.2026.2617690,https://pubmed.ncbi.nlm.nih.gov/41632590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC28,ENSG00000177692,Unsafe,41899445,Identification and Validation of MTFP1 as a Mitochondrial Target Restoring Dynamics and ECM Remodeling in Acute Myocardial Infarction.,2026,10.3390/cimb48030293,https://pubmed.ncbi.nlm.nih.gov/41899445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC28,ENSG00000177692,Unsafe,39911280,Melocular Evolution on Cold Temperature Adaptation of Chinese Rhesus Macaques.,2025,10.2174/0113892029301969240708094053,https://pubmed.ncbi.nlm.nih.gov/39911280/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC28,ENSG00000177692,Unsafe,34440346,TWEAKing the Hippocampus: The Effects of TWEAK on the Genomic Fabric of the Hippocampus in a Neuropsychiatric Lupus Mouse Model.,2021,10.3390/genes12081172,https://pubmed.ncbi.nlm.nih.gov/34440346/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC28,ENSG00000177692,Unsafe,36273131,A novel signature model based on mitochondrial-related genes for predicting survival of colon adenocarcinoma.,2022,10.1186/s12911-022-02020-3,https://pubmed.ncbi.nlm.nih.gov/36273131/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC28,ENSG00000177692,Unsafe,35323693,FOXO3 Expression in Macrophages Is Lowered by a High-Fat Diet and Regulates Colonic Inflammation and Tumorigenesis.,2022,10.3390/metabo12030250,https://pubmed.ncbi.nlm.nih.gov/35323693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC28,ENSG00000177692,Unsafe,35715682,Genetic Analysis of HSP40/DNAJ Family Genes in Parkinson's Disease: a Large Case-Control Study.,2022,10.1007/s12035-022-02920-5,https://pubmed.ncbi.nlm.nih.gov/35715682/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC28,ENSG00000177692,Unsafe,32523018,Whole-genome sequencing provides new insights into genetic mechanisms of tropical adaptation in Nellore (Bos primigenius indicus).,2020,10.1038/s41598-020-66272-7,https://pubmed.ncbi.nlm.nih.gov/32523018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC28,ENSG00000177692,Unsafe,16572726,A genomewide analysis of genes for the heat shock protein 70 chaperone system in the ascidian Ciona intestinalis.,2006,10.1379/csc-137r.1,https://pubmed.ncbi.nlm.nih.gov/16572726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC5B,ENSG00000147570,Unsafe,39899042,Dnajc5b contributes to male fertility by maintaining the mitochondrial functions and autophagic homeostasis during spermiogenesis.,2025,10.1007/s00018-024-05552-1,https://pubmed.ncbi.nlm.nih.gov/39899042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC5B,ENSG00000147570,Unsafe,39448372,Epigenetic associations with kidney disease in individuals of African ancestry with APOL1 high-risk genotypes and HIV.,2025,10.1093/ndt/gfae237,https://pubmed.ncbi.nlm.nih.gov/39448372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC5B,ENSG00000147570,Unsafe,36723955,DNAJB8 facilitates autophagic-lysosomal degradation of viral Vif protein and restricts HIV-1 virion infectivity by rescuing APOBEC3G expression in host cells.,2023,10.1096/fj.202201738r,https://pubmed.ncbi.nlm.nih.gov/36723955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC5B,ENSG00000147570,Unsafe,34580317,Integration and gene co-expression network analysis of scRNA-seq transcriptomes reveal heterogeneity and key functional genes in human spermatogenesis.,2021,10.1038/s41598-021-98267-3,https://pubmed.ncbi.nlm.nih.gov/34580317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC5B,ENSG00000147570,Unsafe,20499929,Palmitoylation and testis-enriched expression of the cysteine-string protein beta isoform.,2010,10.1021/bi100550h,https://pubmed.ncbi.nlm.nih.gov/20499929/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC5B,ENSG00000147570,Unsafe,35117353,Microenvironment-related prognostic genes in esophageal cancer.,2020,10.21037/tcr-20-2288,https://pubmed.ncbi.nlm.nih.gov/35117353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC5B,ENSG00000147570,Unsafe,29182667,Heat shock proteins HSPB8 and DNAJC5B have HCV antiviral activity.,2017,10.1371/journal.pone.0188467,https://pubmed.ncbi.nlm.nih.gov/29182667/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC5B,ENSG00000147570,Unsafe,17034881,Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells.,2007,10.1016/j.bbamcr.2006.08.054,https://pubmed.ncbi.nlm.nih.gov/17034881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC5B,ENSG00000147570,Unsafe,27081464,Down-regulation of HSP40 gene family following OCT4B1 suppression in human tumor cell lines.,2016,,https://pubmed.ncbi.nlm.nih.gov/27081464/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC5B,ENSG00000147570,Unsafe,16477021,CSPalpha-deficiency causes massive and rapid photoreceptor degeneration.,2006,10.1073/pnas.0510060103,https://pubmed.ncbi.nlm.nih.gov/16477021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC5B,ENSG00000147570,Unsafe,29700654,The protein-protein interaction network and clinical significance of heat-shock proteins in esophageal squamous cell carcinoma.,2018,10.1007/s00726-018-2569-8,https://pubmed.ncbi.nlm.nih.gov/29700654/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC5B,ENSG00000147570,Unsafe,25122905,Characterization of transcriptomes of cochlear inner and outer hair cells.,2014,10.1523/jneurosci.1690-14.2014,https://pubmed.ncbi.nlm.nih.gov/25122905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAJC5B,ENSG00000147570,Unsafe,22666496,Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy.,2012,10.1371/journal.pone.0038240,https://pubmed.ncbi.nlm.nih.gov/22666496/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAL1,ENSG00000119661,Unsafe,38454159,BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly.,2024,10.1038/s44319-024-00112-x,https://pubmed.ncbi.nlm.nih.gov/38454159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAL1,ENSG00000119661,Unsafe,39449805,Unveiling the therapeutic potential: KBU2046 halts triple-negative breast cancer cell migration by constricting TGF-β1 activation in vitro.,2024,10.32604/or.2024.049348,https://pubmed.ncbi.nlm.nih.gov/39449805/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAL1,ENSG00000119661,Unsafe,39180133,Characterization of pathogenic genetic variants in Russian patients with primary ciliary dyskinesia using gene panel sequencing and transcript analysis.,2024,10.1186/s13023-024-03318-3,https://pubmed.ncbi.nlm.nih.gov/39180133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAL1,ENSG00000119661,Unsafe,38364346,Diesel exhaust particle exposure exacerbates ciliary and epithelial barrier dysfunction in the multiciliated bronchial epithelium models.,2024,10.1016/j.ecoenv.2024.116090,https://pubmed.ncbi.nlm.nih.gov/38364346/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAL1,ENSG00000119661,Unsafe,39104315,Obesity impairs ciliary function and mucociliary clearance in the murine airway epithelium.,2024,10.1152/ajplung.00114.2024,https://pubmed.ncbi.nlm.nih.gov/39104315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAL1,ENSG00000119661,Unsafe,25761592,Comparative analysis of testis transcriptomes from triploid and fertile diploid cyprinid fish.,2015,10.1095/biolreprod.114.125609,https://pubmed.ncbi.nlm.nih.gov/25761592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAL1,ENSG00000119661,Unsafe,22018492,Knockdown of MAP4 and DNAL1 produces a post-fusion and pre-nuclear translocation impairment in HIV-1 replication.,2012,10.1016/j.virol.2011.09.015,https://pubmed.ncbi.nlm.nih.gov/22018492/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAL1,ENSG00000119661,Unsafe,21496787,"Primary ciliary dyskinesia caused by homozygous mutation in DNAL1, encoding dynein light chain 1.",2011,10.1016/j.ajhg.2011.03.018,https://pubmed.ncbi.nlm.nih.gov/21496787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAL1,ENSG00000119661,Unsafe,15845866,Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients.,2005,10.1165/rcmb.2004-0335oc,https://pubmed.ncbi.nlm.nih.gov/15845866/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAL1,ENSG00000119661,Unsafe,22157010,Functional architecture of the outer arm dynein conformational switch.,2012,10.1074/jbc.m111.286211,https://pubmed.ncbi.nlm.nih.gov/22157010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAL1,ENSG00000119661,Unsafe,9231261,"Use of a GnRH antagonist in conjunction with low amplitude, high frequency LH pulses to induce follicular growth without an LH surge and ovulation in ewes.",1997,10.1016/s0378-4320(96)01624-7,https://pubmed.ncbi.nlm.nih.gov/9231261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNAL1,ENSG00000119661,Unsafe,42355366,"Mechanisms Underlying Male Reproductive Toxicity Induced by Sublethal β-Cypermethrin Exposure in &lt;i&gt;Antheraea pernyi&lt;/i&gt; (Guérin-Méneville, 1855) (Saturniidae).",2026,10.3390/insects17060633,https://pubmed.ncbi.nlm.nih.gov/42355366/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,41731497,DNAH3 interacts with DNALI1 and is required for sperm flagellum function and male fertility.,2026,10.1186/s12958-026-01538-9,https://pubmed.ncbi.nlm.nih.gov/41731497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,42348434,The KIF6-RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly.,2026,10.1002/advs.76263,https://pubmed.ncbi.nlm.nih.gov/42348434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,39912490,LRRC56 deletion causes primary ciliary dyskinesia in mice characterized by dynein arms defects.,2025,10.1242/bio.061846,https://pubmed.ncbi.nlm.nih.gov/39912490/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,42089334,mRNA therapy improves the composition and motility in CCDC40-deficient cilia in vitro and in vivo.,2026,10.1093/ajrcmb/aanag034,https://pubmed.ncbi.nlm.nih.gov/42089334/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,40146200,Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice.,2025,10.7554/elife.100350,https://pubmed.ncbi.nlm.nih.gov/40146200/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,42180707,A homozygous splice-site variant in &lt;i&gt;ZMYND10&lt;/i&gt; causes primary ciliary dyskinesia with primary infertility in a Chinese family.,2026,10.3389/fmed.2026.1838497,https://pubmed.ncbi.nlm.nih.gov/42180707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,37993789,Dnali1 is required for sperm motility and male fertility in mice.,2023,10.1186/s12610-023-00205-y,https://pubmed.ncbi.nlm.nih.gov/37993789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,38348540,DNALI1 Promotes Neurodegeneration after Traumatic Brain Injury via Inhibition of Autophagosome-Lysosome Fusion.,2024,10.1002/advs.202306399,https://pubmed.ncbi.nlm.nih.gov/38348540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,42283488,Investigating the impact of poly(beta amino) ester-mediated FOXJ1 mRNA delivery on differentiation of primary human bronchial epithelial cells.,2026,10.1242/bio.062419,https://pubmed.ncbi.nlm.nih.gov/42283488/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,39503742,DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and mice.,2024,10.7554/elife.96755,https://pubmed.ncbi.nlm.nih.gov/39503742/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,36792588,DNALI1 deficiency causes male infertility with severe asthenozoospermia in humans and mice by disrupting the assembly of the flagellar inner dynein arms and fibrous sheath.,2023,10.1038/s41419-023-05653-y,https://pubmed.ncbi.nlm.nih.gov/36792588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,37083624,DNALI1 interacts with the MEIG1/PACRG complex within the manchette and is required for proper sperm flagellum assembly in mice.,2023,10.7554/elife.79620,https://pubmed.ncbi.nlm.nih.gov/37083624/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,41850444,Benzo[a]pyrene lowers the sperm quality in male rats by downregulating the expression of ZMYND15 and ZMYND10.,2026,10.1016/j.reprotox.2026.109225,https://pubmed.ncbi.nlm.nih.gov/41850444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,42321500,Biallelic loss-of-function variants in DNAH12 cause inner dynein arm defects and sperm head abnormalities leading to male infertility.,2026,10.1007/s10815-026-03929-8,https://pubmed.ncbi.nlm.nih.gov/42321500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,39362423,Retrotransposon involves in photoperiodic spermatogenesis in Brandt's voles (Lasiopodomys brandtii) by co-transcription with flagellar genes.,2024,10.1016/j.ijbiomac.2024.136224,https://pubmed.ncbi.nlm.nih.gov/39362423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,40591047,Identification of key biomarkers and potential therapeutic drugs in nasopharyngeal carcinoma based on comprehensive bioinformatics analysis.,2025,10.1007/s12672-025-03047-4,https://pubmed.ncbi.nlm.nih.gov/40591047/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,40457935,A novel frameshift variant in AXDND1 may cause multiple morphological abnormalities of the sperm flagella in a consanguineous Pakistani family.,2025,10.4103/aja202538,https://pubmed.ncbi.nlm.nih.gov/40457935/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,37955080,DNALI1 is a prognosis-related biomarker and correlates with immune infiltrates in low grade glioma.,2023,10.3233/cbm-230139,https://pubmed.ncbi.nlm.nih.gov/37955080/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,40231527,Cilia Plays a Pivotal Role in the Hypersecretion of Airway Mucus in Mice,2024,10.2174/0118761429368288250401054301,https://pubmed.ncbi.nlm.nih.gov/40231527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,36726469,Homozygous mutation in DNALI1 leads to asthenoteratozoospermia by affecting the inner dynein arms.,2022,10.3389/fendo.2022.1058651,https://pubmed.ncbi.nlm.nih.gov/36726469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,33763356,Bioinformatics-Based Identification of HDAC Inhibitors as Potential Drugs to Target EGFR Wild-Type Non-Small-Cell Lung Cancer.,2021,10.3389/fonc.2021.620154,https://pubmed.ncbi.nlm.nih.gov/33763356/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,31264263,Dysregulation of sputum columnar epithelial cells and products in distinct asthma phenotypes.,2019,10.1111/cea.13452,https://pubmed.ncbi.nlm.nih.gov/31264263/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,29407229,Combined analysis of DNA methylation and gene expression profiles of osteosarcoma identified several prognosis signatures.,2018,10.1016/j.gene.2018.01.093,https://pubmed.ncbi.nlm.nih.gov/29407229/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,30935420,Bioinformatic identification of candidate biomarkers and related transcription factors in nasopharyngeal carcinoma.,2019,10.1186/s12957-019-1605-9,https://pubmed.ncbi.nlm.nih.gov/30935420/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNALI1,ENSG00000163879,Unsafe,31178125,"Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.",2019,10.1016/j.ajhg.2019.04.015,https://pubmed.ncbi.nlm.nih.gov/31178125/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,41005425,Tumor cell-derived DNASE2B mediates M2 macrophage infiltration to promote prostate cancer progression through the PSA secretion.,2025,10.1016/j.yexcr.2025.114772,https://pubmed.ncbi.nlm.nih.gov/41005425/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,40822840,Laser assisted versus photodynamic decontamination of peri-implant mucositis: A split mouth RCT.,2025,10.6026/973206300211103,https://pubmed.ncbi.nlm.nih.gov/40822840/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,41209572,Comprehensive Analysis of Aberrant m6A RNA Modifications Identifies Prognostic Biomarkers in Non-Small Cell Lung Cancer.,2025,10.7150/ijms.119651,https://pubmed.ncbi.nlm.nih.gov/41209572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,40493560,Multi-omics analysis and single-cell sequencing revealed the lysosome associated molecular subtypes and prognostic model development of papillary thyroid carcinoma.,2025,10.1371/journal.pone.0325486,https://pubmed.ncbi.nlm.nih.gov/40493560/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,40745604,"Digital literacy across disciplines scale for medical students: development, validation, and analysis.",2025,10.1186/s12909-025-07708-4,https://pubmed.ncbi.nlm.nih.gov/40745604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,40629431,Mutational landscape of pure ductal carcinoma in situ and associations with disease prognosis and response to radiotherapy.,2025,10.1186/s13058-025-02080-z,https://pubmed.ncbi.nlm.nih.gov/40629431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,40936767,Development of a prognostic RiskScore model using efferocytosis-related signature genes for lung adenocarcinoma.,2025,10.7717/peerj.19892,https://pubmed.ncbi.nlm.nih.gov/40936767/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,41515641,Leveraging Large-Scale Public Data for Artificial Intelligence-Driven Chest X-Ray Analysis and Diagnosis.,2026,10.3390/diagnostics16010146,https://pubmed.ncbi.nlm.nih.gov/41515641/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,38893643,"Enhancing Accuracy in Breast Density Assessment Using Deep Learning: A Multicentric, Multi-Reader Study.",2024,10.3390/diagnostics14111117,https://pubmed.ncbi.nlm.nih.gov/38893643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,39253069,"Digital Clock and Recall: a digital, process-driven evolution of the Mini-Cog.",2024,10.3389/fnhum.2024.1337851,https://pubmed.ncbi.nlm.nih.gov/39253069/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,36079086,Deep Learning-Based Automatic Detection of ASPECTS in Acute Ischemic Stroke: Improving Stroke Assessment on CT Scans.,2022,10.3390/jcm11175159,https://pubmed.ncbi.nlm.nih.gov/36079086/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,35725583,Origin and significance of the human DNase repertoire.,2022,10.1038/s41598-022-14133-w,https://pubmed.ncbi.nlm.nih.gov/35725583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,36700009,Reconstruction of a nail bed with double-layer artificial dermis for a pincer nail: A case report and literature review.,2022,10.3389/fsurg.2022.1047171,https://pubmed.ncbi.nlm.nih.gov/36700009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,36980351,Leveraging Deep Learning Decision-Support System in Specialized Oncology Center: A Multi-Reader Retrospective Study on Detection of Pulmonary Lesions in Chest X-ray Images.,2023,10.3390/diagnostics13061043,https://pubmed.ncbi.nlm.nih.gov/36980351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,37957334,Effect of multimodal diagnostic approach using deep learning-based automated detection algorithm for active pulmonary tuberculosis.,2023,10.1038/s41598-023-47146-0,https://pubmed.ncbi.nlm.nih.gov/37957334/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,36725356,Effects of Expert-Determined Reference Standards in Evaluating the Diagnostic Performance of a Deep Learning Model: A Malignant Lung Nodule Detection Task on Chest Radiographs.,2023,10.3348/kjr.2022.0548,https://pubmed.ncbi.nlm.nih.gov/36725356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,32692300,Deep Learning-based Automatic Detection Algorithm for Reducing Overlooked Lung Cancers on Chest Radiographs.,2020,10.1148/radiol.2020200165,https://pubmed.ncbi.nlm.nih.gov/32692300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,37370955,Estimating the Volume of Nodules and Masses on Serial Chest Radiography Using a Deep-Learning-Based Automatic Detection Algorithm: A Preliminary Study.,2023,10.3390/diagnostics13122060,https://pubmed.ncbi.nlm.nih.gov/37370955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,37048143,High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology.,2023,10.3390/cells12071070,https://pubmed.ncbi.nlm.nih.gov/37048143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,33243843,Development and validation of a deep learning algorithm detecting 10 common abnormalities on chest radiographs.,2021,10.1183/13993003.03061-2020,https://pubmed.ncbi.nlm.nih.gov/33243843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,42135760,Cross-cultural adaptation and psychometric validation of the interdisciplinary digital literacy scale for medical students: the Turkish version (DLAD-TR).,2026,10.1186/s12909-026-09449-4,https://pubmed.ncbi.nlm.nih.gov/42135760/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,27388715,The medial and lateral epicondyle as a reliable landmark for intra-operative joint line determination in revision knee arthroplasty.,2016,10.1302/2046-3758.57.bjr-2016-0002.r1,https://pubmed.ncbi.nlm.nih.gov/27388715/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,29565969,The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development.,2018,10.1371/journal.pgen.1007278,https://pubmed.ncbi.nlm.nih.gov/29565969/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,33204712,Identification of Differential Gene Expression Pattern in Lens Epithelial Cells Derived from Cataractous and Noncataractous Lenses of Shumiya Cataract Rat.,2020,10.1155/2020/7319590,https://pubmed.ncbi.nlm.nih.gov/33204712/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,9404405,[Response of the coronary arteries to cold test and flow velocity increase is improved by deferoxamine but not by L-arginine in diabetic patients].,1997,,https://pubmed.ncbi.nlm.nih.gov/9404405/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,12944971,Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens.,2003,10.1038/nature01895,https://pubmed.ncbi.nlm.nih.gov/12944971/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,11700027,"Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase.",2001,10.1006/bbrc.2001.5894,https://pubmed.ncbi.nlm.nih.gov/11700027/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DNASE2B,ENSG00000137976,Unsafe,11376952,"The cloning, genomic structure, localization, and expression of human deoxyribonuclease IIbeta.",2001,10.1016/s0378-1119(01)00434-6,https://pubmed.ncbi.nlm.nih.gov/11376952/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,42833214,DND1-NANOS3 shapes the PGC transcriptome via a heptanucleotide sequence in mRNA 3' UTRs.,2026,10.1016/j.molcel.2026.09.010,https://pubmed.ncbi.nlm.nih.gov/42833214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,42343208,Human primordial germ cell heterogeneity in vitro is associated with distinctive biological states.,2026,10.1186/s11658-026-00986-w,https://pubmed.ncbi.nlm.nih.gov/42343208/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,41582673,Cell-autonomous control coupled with tissue context regulates the cessation of migration at the site of organ development.,2026,10.1242/dev.205271,https://pubmed.ncbi.nlm.nih.gov/41582673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,40410171,RNA-binding proteins DND1 and NANOS3 cooperatively suppress the entry of germ cell lineage.,2025,10.1038/s41467-025-57490-6,https://pubmed.ncbi.nlm.nih.gov/40410171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,40060892,"Generation of primordial germ cell-like cells by two germ plasm components, &lt;i&gt;dnd1&lt;/i&gt; and &lt;i&gt;nanos3&lt;/i&gt;, in medaka (&lt;i&gt;Oryzias latipes&lt;/i&gt;).",2025,10.1016/j.isci.2025.111977,https://pubmed.ncbi.nlm.nih.gov/40060892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,38639895,Characterization of potential spermatogonia biomarker genes in the European eel (Anguilla anguilla).,2024,10.1007/s10695-024-01338-1,https://pubmed.ncbi.nlm.nih.gov/38639895/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,40053212,"Dead-End protein expression, function, and mutation in cancer: a systematic review.",2025,10.1007/s11033-025-10325-5,https://pubmed.ncbi.nlm.nih.gov/40053212/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,38928079,The Role of Z Chromosome Localization Gene psmd9 in Spermatogenesis of Cynoglossus semilaevis.,2024,10.3390/ijms25126372,https://pubmed.ncbi.nlm.nih.gov/38928079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,39123110,Less is more: CRISPR/Cas9-based mutations in DND1 gene enhance tomato resistance to powdery mildew with low fitness costs.,2024,10.1186/s12870-024-05428-3,https://pubmed.ncbi.nlm.nih.gov/39123110/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,37076592,Loss of Dead end1 induces testicular teratomas from primordial germ cells that failed to undergo sexual differentiation in embryonic testes.,2023,10.1038/s41598-023-33706-x,https://pubmed.ncbi.nlm.nih.gov/37076592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,36713075,Infertility control of transgenic fluorescent zebrafish with targeted mutagenesis of the dnd1 gene by CRISPR/Cas9 genome editing.,2023,10.3389/fgene.2023.1029200,https://pubmed.ncbi.nlm.nih.gov/36713075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,38271475,Splicing factor SRSF1 is essential for homing of precursor spermatogonial stem cells in mice.,2024,10.7554/elife.89316,https://pubmed.ncbi.nlm.nih.gov/38271475/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,39232097,"Transcriptome, hormonal, and secondary metabolite changes in leaves of DEFENSE NO DEATH 1 (DND1) silenced potato plants.",2024,10.1038/s41598-024-71380-9,https://pubmed.ncbi.nlm.nih.gov/39232097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,39903313,"Dietary organic acid blend modulates hemato-immunological parameters, digestive and reproductive performances in red tilapia (Oreochromis niloticus × O. mossambicus) broodstock.",2025,10.1007/s10695-025-01459-1,https://pubmed.ncbi.nlm.nih.gov/39903313/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,36246621,A homozygous missense variant in DND1 causes non-obstructive azoospermia in humans.,2022,10.3389/fgene.2022.1017302,https://pubmed.ncbi.nlm.nih.gov/36246621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,39999035,A Tiered Approach to Exome Sequencing Analysis in Early-Onset Primary Ovarian Insufficiency.,2025,10.1210/clinem/dgaf124,https://pubmed.ncbi.nlm.nih.gov/39999035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,38311675,Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1.,2024,10.1007/s10565-024-09851-y,https://pubmed.ncbi.nlm.nih.gov/38311675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,37180974,Oxygen availability influences the incidence of testicular teratoma in &lt;i&gt;Dnd1Ter/+&lt;/i&gt; mice.,2023,10.3389/fgene.2023.1179256,https://pubmed.ncbi.nlm.nih.gov/37180974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,36857387,The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation.,2023,10.1371/journal.pgen.1010656,https://pubmed.ncbi.nlm.nih.gov/36857387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,36807972,Linking human Dead end 1 (DND1) variants to male infertility employing zebrafish embryos.,2023,10.1093/humrep/dead031,https://pubmed.ncbi.nlm.nih.gov/36807972/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,37651267,Chronic Paternal/Maternal Exposure to Environmental Concentrations of Imidacloprid and Thiamethoxam Causes Intergenerational Toxicity in Zebrafish Offspring.,2023,10.1021/acs.est.3c04371,https://pubmed.ncbi.nlm.nih.gov/37651267/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,34721738,High DND1 Level Indicates a Poor Prognostic Factor in Prostate Cancer.,2021,10.1155/2021/9948241,https://pubmed.ncbi.nlm.nih.gov/34721738/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,38547396,Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs-a proof-of-concept study with doxorubicin.,2024,10.1093/toxsci/kfae041,https://pubmed.ncbi.nlm.nih.gov/38547396/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,39238187,Multi-omics Analysis to Identify Key Immune Genes for Osteoporosis based on Machine Learning and Single-cell Analysis.,2024,10.1111/os.14172,https://pubmed.ncbi.nlm.nih.gov/39238187/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,37311377,Norethindrone suppress the germ cell development via androgen receptor resulting in male bias.,2023,10.1016/j.aquatox.2023.106604,https://pubmed.ncbi.nlm.nih.gov/37311377/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,39113050,"The regulatory effects of water probiotic supplementation on the blood physiology, reproductive performance, and its related genes in Red Tilapia (Oreochromis niloticus X O. mossambicus).",2024,10.1186/s12917-024-04190-w,https://pubmed.ncbi.nlm.nih.gov/39113050/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,30999629,Dnd1 Knockout in Sturgeons By CRISPR/Cas9 Generates Germ Cell Free Host for Surrogate Production.,2019,10.3390/ani9040174,https://pubmed.ncbi.nlm.nih.gov/30999629/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,37375913,Genomic Analysis Highlights Putative Defective Susceptibility Genes in Tomato Germplasm.,2023,10.3390/plants12122289,https://pubmed.ncbi.nlm.nih.gov/37375913/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,30043189,Exposure of Rat Neural Stem Cells to Ethanol Affects Cell Numbers and Alters Expression of 28 Proteins.,2018,10.1007/s11064-018-2600-1,https://pubmed.ncbi.nlm.nih.gov/30043189/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,23890083,APOBEC3 inhibits DEAD-END function to regulate microRNA activity.,2013,10.1186/1471-2199-14-16,https://pubmed.ncbi.nlm.nih.gov/23890083/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,34063239,Identification of Susceptibility Genes in Castanea sativa and Their Transcription Dynamics following Pathogen Infection.,2021,10.3390/plants10050913,https://pubmed.ncbi.nlm.nih.gov/34063239/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,26864483,T-cell internal antigen 1 counteracts somatic RNA degradation during early Xenopus embryogenesis.,2015,10.1387/ijdb.150137db,https://pubmed.ncbi.nlm.nih.gov/26864483/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,26719902,Analysis of salicylic acid-dependent pathways in Arabidopsis thaliana following infection with Plasmodiophora brassicae and the influence of salicylic acid on disease.,2016,10.1111/mpp.12361,https://pubmed.ncbi.nlm.nih.gov/26719902/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,22655094,The ter mutation in the rat Dnd1 gene initiates gonadal teratomas and infertility in both genders.,2012,10.1371/journal.pone.0038001,https://pubmed.ncbi.nlm.nih.gov/22655094/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,18069663,Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors.,2008,10.1002/gcc.20526,https://pubmed.ncbi.nlm.nih.gov/18069663/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DND1,ENSG00000256453,Unsafe,25332888,Immortalized tumor derived rat fibroblasts as feeder cells facilitate the cultivation of male embryonic stem cells from the rat strain WKY/Ztm.,2014,10.1186/2193-1801-3-588,https://pubmed.ncbi.nlm.nih.gov/25332888/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,42108312,DOCK1 inhibitor Box5 (TFA) suppresses proliferation of AML cell lines and prolongs survival in AML xenograft models.,2026,10.1038/s41598-026-51858-4,https://pubmed.ncbi.nlm.nih.gov/42108312/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,42396785,Stanniocalcin-1 Attenuates Cardiac Fibrosis Post Ischemia-Reperfusion Injury by Targeting the DOCKER Domain of Dedicator of Cytokinesis 1.,2026,10.1161/jaha.125.047180,https://pubmed.ncbi.nlm.nih.gov/42396785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,42652043,"ELMO1 and Rac1 Signaling in Kidney Disease: Molecular Mechanisms, Context-Dependent Roles, and Therapeutic Potential.",2026,10.3390/biomedicines14081660,https://pubmed.ncbi.nlm.nih.gov/42652043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,42541488,"Sodium Overload-Related Molecular Subtypes and a Four-Gene Prognostic Signature Predict Survival, Immune Landscape, and Therapeutic Response in Acute Myeloid Leukemia.",2026,10.1002/mc.70158,https://pubmed.ncbi.nlm.nih.gov/42541488/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,42626114,Spatial transcriptomics reveal heterogeneous cell‒cell interactions among brain regions in cuprizone model consistent with multiple sclerosis lesions.,2026,10.3389/fbinf.2026.1832826,https://pubmed.ncbi.nlm.nih.gov/42626114/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,42490412,Identification of a prognostic signature based on expression of post-translational modification-related genes in acute myeloid leukemia.,2026,10.1093/jjco/hyag111,https://pubmed.ncbi.nlm.nih.gov/42490412/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,39379467,"DOCK1 deficiency drives placental trophoblast cell dysfunction by influencing inflammation and oxidative stress, hallmarks of preeclampsia.",2024,10.1038/s41440-024-01920-3,https://pubmed.ncbi.nlm.nih.gov/39379467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,40105697,"Dock1 functions in Schwann cells to regulate development, maintenance, and repair.",2025,10.1083/jcb.202311041,https://pubmed.ncbi.nlm.nih.gov/40105697/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,40355246,Inhibition of DOCK1 suppresses Notch signalling pathway and impairs leukaemogenesis.,2025,10.1111/bjh.20140,https://pubmed.ncbi.nlm.nih.gov/40355246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,38415469,"TBOPP, a DOCK1 Inhibitor, Potentiates Cisplatin Efficacy in Breast Cancer by Regulating Twist-mediated EMT.",2025,10.2174/0115680096281231240202073558,https://pubmed.ncbi.nlm.nih.gov/38415469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,42114173,Integrin-focal adhesion-cytoskeleton signaling axis variations and genetic susceptibility to SCD-CAD.,2026,10.1016/j.forsciint.2026.112999,https://pubmed.ncbi.nlm.nih.gov/42114173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,38438882,DOCK1 regulates the malignant biological behavior of endometrial cancer through c-Raf/ERK pathway.,2024,10.1186/s12885-024-12030-1,https://pubmed.ncbi.nlm.nih.gov/38438882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,39911025,DOCK1/ELMO1/Rac1 Signaling is Essential for Vitreous-Induced Migration and Contraction of ARPE19 Cells.,2025,10.1089/jop.2024.0173,https://pubmed.ncbi.nlm.nih.gov/39911025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,37967942,DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway.,2024,10.26508/lsa.202302247,https://pubmed.ncbi.nlm.nih.gov/37967942/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,38953149,High DOCK1 expression identifies a distinct prognostic subgroup of pediatric acute myeloid leukemia: Results of the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 trial.,2024,10.1002/pbc.31151,https://pubmed.ncbi.nlm.nih.gov/38953149/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,41516402,Subtype-Specific m&lt;sup&gt;6&lt;/sup&gt;A circRNA Methylation Patterns Identify Epigenetic Biomarker Candidates of Potential Diagnostic and Prognostic Significance in Breast Cancer.,2026,10.3390/ijms27010529,https://pubmed.ncbi.nlm.nih.gov/41516402/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,38803542,MYLK*FLNB and DOCK1*LAMA2 gene-gene interactions associated with rheumatoid arthritis in the focal adhesion pathway.,2024,10.3389/fgene.2024.1375036,https://pubmed.ncbi.nlm.nih.gov/38803542/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,42239881,Discovery and validation of a robust 11-gene prognostic signature via integrative multi-omics profiling in VD-CAG-treated non-M3 AML.,2026,10.3389/fonc.2026.1801526,https://pubmed.ncbi.nlm.nih.gov/42239881/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,38780883,Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype.,2024,10.1007/s10456-024-09921-z,https://pubmed.ncbi.nlm.nih.gov/38780883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,38077322,Construction of an acute myeloid leukemia prognostic model based on m6A-related efferocytosis-related genes.,2023,10.3389/fimmu.2023.1268090,https://pubmed.ncbi.nlm.nih.gov/38077322/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,42733189,Macrophage-Targeted Cyclodextrin-Based Metal-Organic Frameworks Restore Redox-Efferocytosis Coupling to Promote Osteochondral Repair in Temporomandibular Joint Osteoarthritis.,2026,10.1002/adhm.71698,https://pubmed.ncbi.nlm.nih.gov/42733189/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,35217990,Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer.,2022,10.1007/s13238-022-00906-6,https://pubmed.ncbi.nlm.nih.gov/35217990/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,35778533,Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML.,2022,10.1038/s41375-022-01632-y,https://pubmed.ncbi.nlm.nih.gov/35778533/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,32626999,TBOPP enhances the anticancer effect of cisplatin by inhibiting DOCK1 in renal cell carcinoma.,2020,10.3892/mmr.2020.11243,https://pubmed.ncbi.nlm.nih.gov/32626999/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,36756739,Epigenome alterations in food allergy: A systematic review of candidate gene and epigenome-wide association studies.,2023,10.1111/cea.14277,https://pubmed.ncbi.nlm.nih.gov/36756739/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,35008712,The Protective Effects of Lactoferrin on Aflatoxin M1-Induced Compromised Intestinal Integrity.,2021,10.3390/ijms23010289,https://pubmed.ncbi.nlm.nih.gov/35008712/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,27660415,Downregulation of DOCK1 sensitizes bladder cancer cells to cisplatin through preventing epithelial-mesenchymal transition.,2016,10.2147/dddt.s101998,https://pubmed.ncbi.nlm.nih.gov/27660415/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,35544951,DOCKopathies: A systematic review of the clinical pathologies associated with human DOCK pathogenic variants.,2022,10.1002/humu.24398,https://pubmed.ncbi.nlm.nih.gov/35544951/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,32616892,Disease-related cellular protein networks differentially affected under different EGFR mutations in lung adenocarcinoma.,2020,10.1038/s41598-020-67894-7,https://pubmed.ncbi.nlm.nih.gov/32616892/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,32651375,Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.,2020,10.1038/s41467-020-17271-9,https://pubmed.ncbi.nlm.nih.gov/32651375/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOCK1,ENSG00000150760,Unsafe,34899750,A Co-Association Network Analysis Reveals Putative Regulators for Health-Related Traits in Pigs.,2021,10.3389/fimmu.2021.784978,https://pubmed.ncbi.nlm.nih.gov/34899750/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOK6,ENSG00000206052,Unsafe,42332721,Structural insights into the specificity of adaptor proteins Dok5 and Dok6 Docking to Trk receptors.,2026,10.1186/s12964-026-03004-w,https://pubmed.ncbi.nlm.nih.gov/42332721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOK6,ENSG00000206052,Unsafe,42165100,Epigenomewide Association Study of Monozygotic Twins Reveals That Serum Uric Acid Influences DNA Methylation.,2026,10.1017/thg.2026.10063,https://pubmed.ncbi.nlm.nih.gov/42165100/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOK6,ENSG00000206052,Unsafe,40568374,AT-rich interaction domain 5A facilitates axon regeneration through docking protein 6 in the peripheral nervous system.,2025,10.1093/burnst/tkaf012,https://pubmed.ncbi.nlm.nih.gov/40568374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOK6,ENSG00000206052,Unsafe,38351062,Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy.,2024,10.1038/s41392-024-01742-2,https://pubmed.ncbi.nlm.nih.gov/38351062/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOK6,ENSG00000206052,Unsafe,41045986,Targeting the FBXO5-DOK6 axis to overcome temozolomide resistance in glioblastoma via proteasome-cytomechanics regulation.,2025,10.1016/j.canlet.2025.218072,https://pubmed.ncbi.nlm.nih.gov/41045986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOK6,ENSG00000206052,Unsafe,39674387,Genetics of constant and severe pain in the NAPS2 cohort of recurrent acute and chronic pancreatitis patients.,2025,10.1016/j.jpain.2024.104754,https://pubmed.ncbi.nlm.nih.gov/39674387/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOK6,ENSG00000206052,Unsafe,38918843,Cross-species transcriptomics identifies obesity associated genes between human and mouse studies.,2024,10.1186/s12967-024-05414-1,https://pubmed.ncbi.nlm.nih.gov/38918843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOK6,ENSG00000206052,Unsafe,34545688,Association between ABHD1 and DOK6 polymorphisms and susceptibility to Hirschsprung disease in Southern Chinese children.,2021,10.1111/jcmm.16905,https://pubmed.ncbi.nlm.nih.gov/34545688/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOK6,ENSG00000206052,Unsafe,36713578,DNA methylation-based patterns for early diagnostic prediction and prognostic evaluation in colorectal cancer patients with high tumor mutation burden.,2022,10.3389/fonc.2022.1030335,https://pubmed.ncbi.nlm.nih.gov/36713578/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOK6,ENSG00000206052,Unsafe,31486300,DOK6 promoter methylation serves as a potential biomarker affecting prognosis in de novo acute myeloid leukemia.,2019,10.1002/cam4.2540,https://pubmed.ncbi.nlm.nih.gov/31486300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOK6,ENSG00000206052,Unsafe,29872697,"Chromosomal breaks at FRA18C: association with reduced DOK6 expression, altered oncogenic signaling and increased gastric cancer survival.",2017,10.1038/s41698-017-0012-3,https://pubmed.ncbi.nlm.nih.gov/29872697/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOK6,ENSG00000206052,Unsafe,28965333,"Preliminary identification of key miRNAs, signaling pathways, and genes associated with Hirschsprung's disease by analysis of tissue microRNA expression profiles.",2017,10.1007/s12519-017-0064-z,https://pubmed.ncbi.nlm.nih.gov/28965333/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOK6,ENSG00000206052,Unsafe,20565848,"Downstream of tyrosine kinase/docking protein 6, as a novel substrate of tropomyosin-related kinase C receptor, is involved in neurotrophin 3-mediated neurite outgrowth in mouse cortex neurons.",2010,10.1186/1741-7007-8-86,https://pubmed.ncbi.nlm.nih.gov/20565848/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOK6,ENSG00000206052,Unsafe,20078947,[Dok6 promote neurite outgrowth of tropomyosin-related kinase C overexpressed PC12 cells in stimulation of neurotrophin-3].,2009,10.3881/j.issn.1000-503x.2009.06.020,https://pubmed.ncbi.nlm.nih.gov/20078947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOK6,ENSG00000206052,Unsafe,17475918,"FRA18C: a new aphidicolin-inducible fragile site on chromosome 18q22, possibly associated with in vivo chromosome breakage.",2007,10.1136/jmg.2006.044628,https://pubmed.ncbi.nlm.nih.gov/17475918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOK6,ENSG00000206052,Unsafe,17551791,Nt mutation causing laterality defects associated with deletion of rotatin.,2007,10.1007/s00335-007-9023-7,https://pubmed.ncbi.nlm.nih.gov/17551791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOK6,ENSG00000206052,Unsafe,21931561,Genetic association for renal traits among participants of African ancestry reveals new loci for renal function.,2011,10.1371/journal.pgen.1002264,https://pubmed.ncbi.nlm.nih.gov/21931561/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DOK6,ENSG00000206052,Unsafe,15286081,"Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth.",2004,10.1074/jbc.m403726200,https://pubmed.ncbi.nlm.nih.gov/15286081/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPH6,ENSG00000134146,Unsafe,40489632,Clinical and Genetic Factors Associated with Intraoperative Minimum Alveolar Concentration Ratio: A Single-center Retrospective Cohort and Genome-wide Association Study.,2025,10.1097/aln.0000000000005602,https://pubmed.ncbi.nlm.nih.gov/40489632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPH6,ENSG00000134146,Unsafe,35267662,Comprehensive Analysis of the Prognosis and Drug Sensitivity of Differentiation-Related lncRNAs in Papillary Thyroid Cancer.,2022,10.3390/cancers14051353,https://pubmed.ncbi.nlm.nih.gov/35267662/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPH6,ENSG00000134146,Unsafe,38993258,A New Ferroptosis-Related Long Non-Coding RNA Risk Model Predicts the Prognosis of Patients With Papillary Thyroid Cancer.,2024,10.14740/wjon1838,https://pubmed.ncbi.nlm.nih.gov/38993258/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPH6,ENSG00000134146,Unsafe,30108417,Structure modeling to function prediction of Uncharacterized Human Protein C15orf41.,2018,10.6026/97320630014206,https://pubmed.ncbi.nlm.nih.gov/30108417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPH6,ENSG00000134146,Unsafe,34725398,Local adaptations of Mediterranean sheep and goats through an integrative approach.,2021,10.1038/s41598-021-00682-z,https://pubmed.ncbi.nlm.nih.gov/34725398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPH6,ENSG00000134146,Unsafe,34370325,Genome-wide association study and pathway analysis for carcass fatness in Nellore cattle measured by ultrasound.,2021,10.1111/age.13129,https://pubmed.ncbi.nlm.nih.gov/34370325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPH6,ENSG00000134146,Unsafe,32245826,A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.,2020,10.1534/g3.120.401128,https://pubmed.ncbi.nlm.nih.gov/32245826/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPH6,ENSG00000134146,Unsafe,31450665,Epigenome-Wide Association Analysis of Differentially Methylated Signals in Blood Samples of Patients with Non-Small-Cell Lung Cancer.,2019,10.3390/jcm8091307,https://pubmed.ncbi.nlm.nih.gov/31450665/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPH6,ENSG00000134146,Unsafe,24813882,"Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.",2014,10.1016/j.ejmech.2014.04.078,https://pubmed.ncbi.nlm.nih.gov/24813882/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPH6,ENSG00000134146,Unsafe,23468660,"The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network.",2013,10.1371/journal.pgen.1003334,https://pubmed.ncbi.nlm.nih.gov/23468660/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPH6,ENSG00000134146,Unsafe,28357244,"Decoding the biosynthesis and function of diphthamide, an enigmatic modification of translation elongation factor 2 (EF2)",2014,10.15698/mic2014.06.151,https://pubmed.ncbi.nlm.nih.gov/28357244/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPH6,ENSG00000134146,Unsafe,23645155,"Insights into diphthamide, key diphtheria toxin effector.",2013,10.3390/toxins5050958,https://pubmed.ncbi.nlm.nih.gov/23645155/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPH6,ENSG00000134146,Unsafe,28061514,A Genome-Wide Association Study of Vertical Cup-Disc Ratio in a Latino Population.,2017,10.1167/iovs.16-19891,https://pubmed.ncbi.nlm.nih.gov/28061514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPH6,ENSG00000134146,Unsafe,23169644,Chemogenomic approach identified yeast YLR143W as diphthamide synthetase.,2012,10.1073/pnas.1214346109,https://pubmed.ncbi.nlm.nih.gov/23169644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPH6,ENSG00000134146,Unsafe,23013770,Comparative genomic analysis of the DUF71/COG2102 family predicts roles in diphthamide biosynthesis and B12 salvage.,2012,10.1186/1745-6150-7-32,https://pubmed.ncbi.nlm.nih.gov/23013770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,41203637,Single-cell analysis unravels divergent gene signatures shaping seminoma stemness and metastasis.,2025,10.1038/s41420-025-02802-4,https://pubmed.ncbi.nlm.nih.gov/41203637/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,42738871,MBD3 Knockdown Promotes the Differentiation of Bovine iPSCs into Primordial Germ Cell-like Cells Associated with Altered Bivalent Modification of TGF-β-Related Genes.,2026,10.3390/cells15171577,https://pubmed.ncbi.nlm.nih.gov/42738871/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,39093695,Developmental pluripotency-associated 4 increases aggressiveness of pituitary neuroendocrine tumors by enhancing cell stemness.,2025,10.1093/neuonc/noae148,https://pubmed.ncbi.nlm.nih.gov/39093695/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,40034318,Unveiling distinctions between mesenchymal stromal cells and stem cells by single-cell transcriptomic analysis.,2025,10.1016/j.heliyon.2025.e42311,https://pubmed.ncbi.nlm.nih.gov/40034318/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,41017273,Prenatal alcohol exposure increases the aggressiveness of estrogen-induced pituitary tumors in male rats.,2025,10.1111/acer.70169,https://pubmed.ncbi.nlm.nih.gov/41017273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,38053127,FGF-independent MEK1/2 signalling in the developing foetal testis is essential for male germline differentiation in mice.,2023,10.1186/s12915-023-01777-x,https://pubmed.ncbi.nlm.nih.gov/38053127/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,38308190,Zygotic Splicing Activation of the Transcriptome is a Crucial Aspect of Maternal-to-Zygotic Transition and Required for the Conversion from Totipotency to Pluripotency.,2024,10.1002/advs.202308496,https://pubmed.ncbi.nlm.nih.gov/38308190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,34767751,"DPPA2, DPPA4, and other DPPA factor epigenomic functions in cell fate and cancer.",2021,10.1016/j.stemcr.2021.10.008,https://pubmed.ncbi.nlm.nih.gov/34767751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,40244397,Dppa2 Promotes Early Embryo Development Through Regulating PDH Expression Pattern During Zygotic Genome Activation.,2025,10.3390/ijms26073436,https://pubmed.ncbi.nlm.nih.gov/40244397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,41087166,Placental transcriptomic profiling showed disturbance of chemokine activities and lymphocyte chemotaxis in pregnancy with fetal growth restriction.,2025,10.1080/14767058.2025.2567473,https://pubmed.ncbi.nlm.nih.gov/41087166/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,36581877,Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders.,2022,10.1186/s12916-022-02699-1,https://pubmed.ncbi.nlm.nih.gov/36581877/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,41436486,The solute-binding proteins DppA1-5 of Pseudomonas aeruginosa have distinct substrate profiles.,2025,10.1038/s41598-025-27865-2,https://pubmed.ncbi.nlm.nih.gov/41436486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,38474345,DPPA2/4 Promote the Pluripotency and Proliferation of Bovine Extended Pluripotent Stem Cells by Upregulating the PI3K/AKT/GSK3β/β-Catenin Signaling Pathway.,2024,10.3390/cells13050382,https://pubmed.ncbi.nlm.nih.gov/38474345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,36007377,Dynamic cytosolic foci of DPPA4 in human pluripotent stem cells.,2022,10.1016/j.tice.2022.101893,https://pubmed.ncbi.nlm.nih.gov/36007377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,39325344,Unraveling the mysteries of early embryonic arrest: genetic factors and molecular mechanisms.,2024,10.1007/s10815-024-03259-7,https://pubmed.ncbi.nlm.nih.gov/39325344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,34878123,DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development.,2021,10.1242/dev.200178,https://pubmed.ncbi.nlm.nih.gov/34878123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,37862240,Large-scale meta-genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types.,2023,10.1093/jncics/pkad088,https://pubmed.ncbi.nlm.nih.gov/37862240/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,36532721,Targeting glycolysis in non-small cell lung cancer: Promises and challenges.,2022,10.3389/fphar.2022.1037341,https://pubmed.ncbi.nlm.nih.gov/36532721/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,31180527,"High developmental pluripotency‑associated 4 expression promotes cell proliferation and glycolysis, and predicts poor prognosis in non‑small‑cell lung cancer.",2019,10.3892/mmr.2019.10272,https://pubmed.ncbi.nlm.nih.gov/31180527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,29327467,ERBB3-Binding Protein 1 (EBP1) Is a Novel Developmental Pluripotency-Associated-4 (DPPA4) Cofactor in Human Pluripotent Cells.,2018,10.1002/stem.2776,https://pubmed.ncbi.nlm.nih.gov/29327467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,37954164,Ablation of OCT4 function in cattle embryos by double electroporation of CRISPR-Cas for DNA and RNA targeting (CRISPR-DART).,2023,10.1093/pnasnexus/pgad343,https://pubmed.ncbi.nlm.nih.gov/37954164/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,35908548,The intrinsic and extrinsic effects of TET proteins during gastrulation.,2022,10.1016/j.cell.2022.06.049,https://pubmed.ncbi.nlm.nih.gov/35908548/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,19332562,The pluripotency-associated gene Dppa4 is dispensable for embryonic stem cell identity and germ cell development but essential for embryogenesis.,2009,10.1128/mcb.01970-08,https://pubmed.ncbi.nlm.nih.gov/19332562/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,24693477,"The expressions of stem cell markers: Oct4, Nanog, Sox2, nucleostemin, Bmi, Zfx, Tcl1, Tbx3, Dppa4, and Esrrb in bladder, colon, and prostate cancer, and certain cancer cell lines.",2014,10.5115/acb.2014.47.1.1,https://pubmed.ncbi.nlm.nih.gov/24693477/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,26282538,Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity.,2015,10.1186/s13287-015-0137-7,https://pubmed.ncbi.nlm.nih.gov/26282538/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,25338022,High-throughput screening of dipeptide utilization mediated by the ABC transporter DppBCDF and its substrate-binding proteins DppA1-A5 in Pseudomonas aeruginosa.,2014,10.1371/journal.pone.0111311,https://pubmed.ncbi.nlm.nih.gov/25338022/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,23082221,Genome-wide association identifies multiple genomic regions associated with susceptibility to and control of ovine lentivirus.,2012,10.1371/journal.pone.0047829,https://pubmed.ncbi.nlm.nih.gov/23082221/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,22088171,Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells.,2011,10.1186/scrt87,https://pubmed.ncbi.nlm.nih.gov/22088171/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DPPA4,ENSG00000121570,Unsafe,20126548,Expression map of the human exome in CD34+ cells and blood cells: increased alternative splicing in cell motility and immune response genes.,2010,10.1371/journal.pone.0008990,https://pubmed.ncbi.nlm.nih.gov/20126548/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRC7,ENSG00000159625,Unsafe,40089458,Core N-DRC components play a crucial role in embryonic development and postnatal organ development.,2025,10.1038/s41419-025-07506-2,https://pubmed.ncbi.nlm.nih.gov/40089458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRC7,ENSG00000159625,Unsafe,40783914,[Immunological mechanism of non-obstructive azoospermia: An exploration based on bioinformatics and machine learning].,2024,,https://pubmed.ncbi.nlm.nih.gov/40783914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRC7,ENSG00000159625,Unsafe,38650655,Effects of &lt;i&gt;Tcte1&lt;/i&gt; knockout on energy chain transportation and spermatogenesis: implications for male infertility.,2024,10.1093/hropen/hoae020,https://pubmed.ncbi.nlm.nih.gov/38650655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRC7,ENSG00000159625,Unsafe,31961863,Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice.,2020,10.1371/journal.pgen.1008585,https://pubmed.ncbi.nlm.nih.gov/31961863/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRC7,ENSG00000159625,Unsafe,37895049,A Comprehensive Genetic Study of Microtubule-Associated Gene Clusters for Male Infertility in a Taiwanese Cohort.,2023,10.3390/ijms242015363,https://pubmed.ncbi.nlm.nih.gov/37895049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRC7,ENSG00000159625,Unsafe,21289096,Regulation of flagellar motility by the conserved flagellar protein CG34110/Ccdc135/FAP50.,2011,10.1091/mbc.e10-04-0331,https://pubmed.ncbi.nlm.nih.gov/21289096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRC7,ENSG00000159625,Unsafe,31659045,Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex.,2019,10.1073/pnas.1910960116,https://pubmed.ncbi.nlm.nih.gov/31659045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRC7,ENSG00000159625,Unsafe,34239995,Mutations of METTL3 predict response to neoadjuvant chemotherapy in muscle-invasive bladder cancer.,2021,10.18053/jctres.07.202103.009,https://pubmed.ncbi.nlm.nih.gov/34239995/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRC7,ENSG00000159625,Unsafe,22983010,"Novel transglutaminase-like peptidase and C2 domains elucidate the structure, biogenesis and evolution of the ciliary compartment.",2012,10.4161/cc.22068,https://pubmed.ncbi.nlm.nih.gov/22983010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,41155360,The Heteromeric Dopamine Receptor D2:D3 Controls the Gut Recruitment and Suppressive Activity of Regulatory T-Cells.,2025,10.3390/ijms262010069,https://pubmed.ncbi.nlm.nih.gov/41155360/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,42237294,Analysis of genetic polymorphisms and mRNA expression of DRD3 and HTR2A in bruxism.,2026,10.1186/s12903-026-08633-8,https://pubmed.ncbi.nlm.nih.gov/42237294/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,41768124,"Nuclear and membrane-bound hormone receptors in glioblastoma: Expression, functionality, and therapeutic implications.",2026,10.1093/noajnl/vdaf252,https://pubmed.ncbi.nlm.nih.gov/41768124/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,40488893,"Convergent Evolution of Two Dopamine Receptor Genes: Repeated Evolution of Exon 6 Skipping in Drd2, and Repeated Deletion of Exon 6 in Drd3.",2025,10.1007/s00239-025-10255-7,https://pubmed.ncbi.nlm.nih.gov/40488893/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,40358175,"Dopamine Receptor D3 Induces Transient, mTORC1-Dependent Autophagy That Becomes Persistent, AMPK-Mediated, and Neuroprotective in Experimental Models of Huntington's Disease.",2025,10.3390/cells14090652,https://pubmed.ncbi.nlm.nih.gov/40358175/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,42418038,Neu1 deficiency is associated with reduced nicotine responsiveness and dopamine D3 receptor downregulation in zebrafish.,2026,10.1007/s10695-026-01735-8,https://pubmed.ncbi.nlm.nih.gov/42418038/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,41722074,Peripheral Expression of Dopamine Genes as a Biomarker for Cocaine Addiction in Humans.,2026,10.1159/000551119,https://pubmed.ncbi.nlm.nih.gov/41722074/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,41459113,"circFKBP8(5S,6)-encoded protein promotes stress susceptibility in mice by down-regulating dopamine D3 receptor expression and its downstream AMPK/mTOR/ULK1 autophagy signaling.",2026,10.1016/j.gendis.2025.101718,https://pubmed.ncbi.nlm.nih.gov/41459113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,42019962,Repurposing Quetiapine as an Adjuvant Therapeutic Agent for Triple-Negative Breast Cancer.,2026,10.1667/rade-25-00222.1,https://pubmed.ncbi.nlm.nih.gov/42019962/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,42480640,Combined exposure to microplastics and cetylpyridinium chloride disturbs the sociability and brain monoamine neurotransmitters in juvenile zebrafish.,2026,10.1016/j.cbpc.2026.110629,https://pubmed.ncbi.nlm.nih.gov/42480640/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,42151442,MSK1 mediates BDNF-dependent MeCP2-S421 phosphorylation in postnatal striatal development and psychiatric-relevant behaviours.,2026,10.1038/s41380-026-03630-3,https://pubmed.ncbi.nlm.nih.gov/42151442/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,41258136,The influence of dopamine receptor SNPs on substance use disorder in a Jordanian cohort.,2025,10.1186/s13104-025-07523-6,https://pubmed.ncbi.nlm.nih.gov/41258136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,40513807,Dopamine D3 receptor gene is associated with obsessive-compulsive disorder and antidepressant response.,2025,10.1016/j.pnpbp.2025.111428,https://pubmed.ncbi.nlm.nih.gov/40513807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,39954359,Dopamine receptor D3 affects the expression of Period1 in mouse cells via DRD3-ERK-CREB signaling.,2025,10.1016/j.bbrc.2025.151470,https://pubmed.ncbi.nlm.nih.gov/39954359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,40324674,Dopamine D3 receptor in the nucleus accumbens modulates opioid taking and seeking in mice.,2025,10.1016/j.pnpbp.2025.111389,https://pubmed.ncbi.nlm.nih.gov/40324674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,39917929,Research on Neuroimmune Gastrointestinal Diseases Based on Artificial Intelligence: Molecular Dynamics Analysis of Caffeine and DRD3 Protein.,2026,10.2174/0113892010325902241120111429,https://pubmed.ncbi.nlm.nih.gov/39917929/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,41903904,Neurobehavioral toxicity of paroxetine in Gambusia affinis: Dissociated behavioral syndromes and impaired monoaminergic neurotransmission.,2026,10.1016/j.envpol.2026.128028,https://pubmed.ncbi.nlm.nih.gov/41903904/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,42525625,Dopaminergic genetic variation and response to social comparative feedback when learning a motor sequence task.,2026,10.1371/journal.pone.0354275,https://pubmed.ncbi.nlm.nih.gov/42525625/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,42540671,Receptor Contribution Reallocation After Removal of Literature-Derived Weights: A Secondary Sensitivity Analysis of the Integrated Ki-DDD-TWAS Pipeline for Antipsychotic Lipid-Trait Prioritization.,2026,10.7759/cureus.113701,https://pubmed.ncbi.nlm.nih.gov/42540671/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,42741404,Inflammation and neuropsychiatric symptoms in Parkinson's disease: a genetic association.,2026,10.3389/fnagi.2026.1877657,https://pubmed.ncbi.nlm.nih.gov/42741404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,41737549,Pharmacogenomics of risperidone in autism spectrum disorder: a minireview.,2026,10.3389/fphar.2026.1768109,https://pubmed.ncbi.nlm.nih.gov/41737549/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,42052100,Biomarker Variants of Dopamine Receptor Genes Influence the Binding Interaction Between Dopamine Receptor and Risperidone.,2026,10.2147/dddt.s587705,https://pubmed.ncbi.nlm.nih.gov/42052100/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,41530533,Melatonin Alleviated Cadmium Induced Microbiota-Gut-Brain Disorder in Adult Zebrafish: Insights from Transcriptomic and Microbiome Analysis.,2026,10.1007/s12011-025-04974-7,https://pubmed.ncbi.nlm.nih.gov/41530533/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,41532439,Chitosan-based nanoparticles for targeted delivery of 17β-estradiol to enhance SIRT1-mediated autophagy and mitigate rotenone-induced Parkinson's disease.,2026,10.1039/d5tb02351c,https://pubmed.ncbi.nlm.nih.gov/41532439/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,40140491,The neural pathway from the superior subpart of the medial habenula to the interpeduncular nucleus suppresses anxiety.,2025,10.1038/s41380-025-02964-8,https://pubmed.ncbi.nlm.nih.gov/40140491/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,40854477,Developmental toxicity and gene expression alterations induced by the synthetic cannabinoid CUMYL-4CN-BINACA in zebrafish embryos.,2025,10.1016/j.fct.2025.115712,https://pubmed.ncbi.nlm.nih.gov/40854477/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,38380709,The dopamine 3 receptor as a candidate biomarker and therapeutic for opioid use disorder.,2024,10.1111/adb.13369,https://pubmed.ncbi.nlm.nih.gov/38380709/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,39468580,The association of gene polymorphisms of adenosine and dopamine receptors with the response to caffeine citrate treatment in infants with apnea of prematurity: a prospective nested case-control study.,2024,10.1186/s13052-024-01776-w,https://pubmed.ncbi.nlm.nih.gov/39468580/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,36428964,Dopaminergic Signalling Enhances IL-2 Production and Strengthens Anti-Tumour Response Exerted by Cytotoxic T Lymphocytes in a Melanoma Mouse Model.,2022,10.3390/cells11223536,https://pubmed.ncbi.nlm.nih.gov/36428964/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRD3,ENSG00000151577,Unsafe,8415635,Selective loss of dopamine D3-type receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia.,1993,10.1073/pnas.90.19.8942,https://pubmed.ncbi.nlm.nih.gov/8415635/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRICH1,ENSG00000189269,Unsafe,30970261,Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies.,2019,10.1016/j.celrep.2019.02.041,https://pubmed.ncbi.nlm.nih.gov/30970261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRICH1,ENSG00000189269,Unsafe,34800203,Identification of Hub Genes Associated with Abnormal Endothelial Function in Early Coronary Atherosclerosis.,2022,10.1007/s10528-021-10139-7,https://pubmed.ncbi.nlm.nih.gov/34800203/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRICH1,ENSG00000189269,Unsafe,31934208,Characterization of TCF4-mediated oncogenic role in cutaneous squamous cell carcinoma.,2019,,https://pubmed.ncbi.nlm.nih.gov/31934208/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DRICH1,ENSG00000189269,Unsafe,26308446,Identification of Human N-Myristoylated Proteins from Human Complementary DNA Resources by Cell-Free and Cellular Metabolic Labeling Analyses.,2015,10.1371/journal.pone.0136360,https://pubmed.ncbi.nlm.nih.gov/26308446/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,38837535,DCAF2 regulates the proliferation and differentiation of mouse progenitor spermatogonia by targeting p21 and thymine DNA glycosylase.,2024,10.1111/cpr.13676,https://pubmed.ncbi.nlm.nih.gov/38837535/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,40574400,Denticleless E3 Ubiquitin Protein Ligase Homolog as a Potential Biomarker for Adrenocortical Carcinoma Screening.,2026,10.2174/0118715303334496250518033852,https://pubmed.ncbi.nlm.nih.gov/40574400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,41835183,Machine-Learning-Accelerated Design of Ternary Carrier-Free Nanomedicine for Intranasal Therapy of Brain Metastatic Non-small-cell Lung Cancer.,2026,10.34133/research.1180,https://pubmed.ncbi.nlm.nih.gov/41835183/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42908707,Non-invasive preoperative MRI-based deep transfer learning radiomics model for predicting meningioma brain invasion.,2026,10.3389/fonc.2026.1935311,https://pubmed.ncbi.nlm.nih.gov/42908707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42710180,Striatal temporal interference stimulation alleviates motor deficits and confers neuroprotection in an MPTP-induced mouse model of Parkinson's disease with associated improvements in mitochondrial homeostasis.,2026,10.1016/j.neurot.2026.e01064,https://pubmed.ncbi.nlm.nih.gov/42710180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42243342,Multi-omics profiling reveals EMT-driven fibroblast activation in the renal injury niche.,2026,10.1007/s00018-026-06226-w,https://pubmed.ncbi.nlm.nih.gov/42243342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,38609375,RUVBL1 ubiquitination by DTL promotes RUVBL1/2-β-catenin-mediated transcriptional regulation of NHEJ pathway and enhances radiation resistance in breast cancer.,2024,10.1038/s41419-024-06651-4,https://pubmed.ncbi.nlm.nih.gov/38609375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42081965,The role of DTL in maintaining survival of cochlear hair cell and hearing function.,2026,10.1016/j.neuroscience.2026.04.032,https://pubmed.ncbi.nlm.nih.gov/42081965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,41794796,Integrated bioinformatics analysis and experimental validation reveal Pevonedistat as a promising therapeutic agent modulating the CRL4-DTL-p21/p53 axis in nasopharyngeal carcinoma.,2026,10.1186/s41065-026-00661-2,https://pubmed.ncbi.nlm.nih.gov/41794796/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,41452608,Forecasting Spoken Language Development in Children With Cochlear Implants Using Preimplant Magnetic Resonance Imaging.,2026,10.1001/jamaoto.2025.4694,https://pubmed.ncbi.nlm.nih.gov/41452608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,40680432,The TRIM22-CDT2 axis is the key mediator of the p53-Rb signals in growth control of HPV-positive cervical carcinoma cells.,2025,10.1016/j.neo.2025.101211,https://pubmed.ncbi.nlm.nih.gov/40680432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42527318,A systematic evaluation of the sources of nonuniform coverage in RNA-seq and limitations of current practices.,2026,10.1261/rna.080852.125,https://pubmed.ncbi.nlm.nih.gov/42527318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42657999,Protective Effect of Calcitonin Gene-Related Peptide on Corneal Epithelial Barrier in Experimental Dry Eye Models.,2026,10.1167/iovs.67.10.65,https://pubmed.ncbi.nlm.nih.gov/42657999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42419788,Colchicine enhances macrophage cholesterol efflux by targeting DTL-mediated ubiquitination and degradation of ABCA1.,2026,10.1136/rmdopen-2025-006553,https://pubmed.ncbi.nlm.nih.gov/42419788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,35711069,Mice lacking DCAF2 in placenta die at the gastrulation stage.,2022,10.1007/s00441-022-03655-4,https://pubmed.ncbi.nlm.nih.gov/35711069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,40391156,Rewired glycolysis by DTL accelerates oncometabolite L-lactate generation to promote breast cancer progression.,2025,10.3389/fonc.2025.1583752,https://pubmed.ncbi.nlm.nih.gov/40391156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42898983,"TRIM22 in cancer: a context-dependent E3 ligase at the interface of interferon, p53, and tumor plasticity.",2026,10.3389/fcell.2026.1977247,https://pubmed.ncbi.nlm.nih.gov/42898983/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,41461624,E2F8 Transcriptionally Activates DTL to Promote Endometrial Cancer Progression Via the MAPK Pathway.,2026,10.1007/s43032-025-02040-0,https://pubmed.ncbi.nlm.nih.gov/41461624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,41687219,Unified therapeutic-prophylactic nucleobase-lipid nanovaccine with STING pathway agonist (2'3'-cGAMP) to prevent tumor growth recurrence and metastasis.,2026,10.1016/j.colsurfb.2026.115540,https://pubmed.ncbi.nlm.nih.gov/41687219/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42613015,Feasibility of Concurrent 1 H MRS and 31 P MRSI at 7 T: Brain Energy Metabolism Responses to Hyperglycemia.,2026,10.1002/nbm.70369,https://pubmed.ncbi.nlm.nih.gov/42613015/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42386910,Feasibility and safety of rapid glofitamab ramp-up.,2026,10.1038/s41375-026-03003-3,https://pubmed.ncbi.nlm.nih.gov/42386910/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42335220,Safe Accelerated Venetoclax Escalation: a phase 1b study of obinutuzumab plus venetoclax with daily ramp-up in CLL.,2026,10.1182/bloodadvances.2026020392,https://pubmed.ncbi.nlm.nih.gov/42335220/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42393723,Short ramp-up glofitamab halves mortality risk after anti-CD19 CAR T-cell therapy failure in patients with diffuse large B-cell lymphoma: final results of the LYSA BiCAR phase 2 trial with a pre-specified external control arm.,2026,10.1186/s13045-026-01816-4,https://pubmed.ncbi.nlm.nih.gov/42393723/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42798161,Extended Multi-Stage Drop-the-Losers Design for Multi-Arm Clinical Trials Using Binary and Survival Endpoints.,2026,10.1002/bimj.70174,https://pubmed.ncbi.nlm.nih.gov/42798161/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42757399,A real-world analysis of adverse events and operational impacts of using T-cell engager therapy in an oncology setting.,2026,10.5737/23688076362350,https://pubmed.ncbi.nlm.nih.gov/42757399/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42241337,Bendamustine/Rituximab Induction Followed by Venetoclax/Rituximab Consolidation in Frontline Treatment of Chronic Lymphocytic Leukemia: A Phase 2 Multi-Center Study.,2026,10.1002/hon.70205,https://pubmed.ncbi.nlm.nih.gov/42241337/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,41744848,Early Experience with Tarlatamab (T-Cell Engagers) for Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Canada: Lessons Learned and Implementation Strategies.,2026,10.3390/curroncol33020084,https://pubmed.ncbi.nlm.nih.gov/41744848/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42385124,Phase I/II Study of Sonrotoclax (BGB-11417) Monotherapy in Patients With Mantle Cell Lymphoma Previously Treated With Anti-CD20 Therapy and a Bruton Tyrosine Kinase Inhibitor.,2026,10.1200/jco-26-00550,https://pubmed.ncbi.nlm.nih.gov/42385124/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42214003,"Dithiolane-Based Reversible ""Trojan Tag"" For Intracellular Protein Delivery and Prodrug Design.",2026,10.1021/acsami.6c02118,https://pubmed.ncbi.nlm.nih.gov/42214003/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,41615298,Preoperative CT-based Radiomics for Predicting Response to Neoadjuvant Chemoimmunotherapy in Esophageal Squamous Cell Carcinoma.,2026,10.1148/rycan.250128,https://pubmed.ncbi.nlm.nih.gov/41615298/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42058013,Venetoclax Plus Hypomethylating Agents for Treatment-Naïve Myelodysplastic Syndromes with Increased Blasts: A Prospective Multicenter Cohort Study.,2026,10.2147/blctt.s592550,https://pubmed.ncbi.nlm.nih.gov/42058013/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42428456,Treatment of recurrent low grade serous ovarian cancer: MEK inhibition and the RAMP 201 trial.,2026,10.21037/gpm-2025-1-71,https://pubmed.ncbi.nlm.nih.gov/42428456/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42415180,"Evaluation of the effect of a long inspiratory ramp time during pressure-controlled ventilation with volume guarantee: study protocol for a randomized, controlled trial.",2026,10.1186/s13063-026-09888-w,https://pubmed.ncbi.nlm.nih.gov/42415180/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42585973,A safety-prioritized trajectory planning method based on multimodal predictive risk field for ramp merging.,2026,10.1016/j.aap.2026.108711,https://pubmed.ncbi.nlm.nih.gov/42585973/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42658749,Redefining Fitness in Chronic Lymphocytic Leukaemia: A Treatment-Specific Framework for the Targeted Therapy Era.,2026,10.1159/ocl/aebag001,https://pubmed.ncbi.nlm.nih.gov/42658749/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,42256356,"Psychometric properties, pragmatic screening cut-offs, and feasibility of two Clock Drawing Test formats in older psychiatric outpatients: Associations with MMSE and HDS-R.",2026,10.1002/pcn5.70351,https://pubmed.ncbi.nlm.nih.gov/42256356/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,17106265,"Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma.",2006,10.4161/cc.5.22.3500,https://pubmed.ncbi.nlm.nih.gov/17106265/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTL,ENSG00000143476,Unsafe,11278750,Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation.,2001,10.1074/jbc.m010802200,https://pubmed.ncbi.nlm.nih.gov/11278750/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTWD2,ENSG00000169570,Unsafe,42309287,Impaired glycoRNA biogenesis in metabolic-dysfunction associated steatotic liver disease.,2026,10.1016/j.jhep.2026.04.034,https://pubmed.ncbi.nlm.nih.gov/42309287/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTWD2,ENSG00000169570,Unsafe,37745798,tRNA-Uridine Aminocarboxypropyltransferase DTW Domain Containing 2 Suppresses Colon Adenocarcinoma Progression.,2023,10.1155/2023/4354536,https://pubmed.ncbi.nlm.nih.gov/37745798/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTWD2,ENSG00000169570,Unsafe,40725187,&lt;i&gt;APOE&lt;/i&gt; Genotype-Stratified Meta-Analysis of Cognitive Decline Reveals Novel Loci for Language and Global Cognitive Function in Older Adults.,2025,10.3390/ijms26146940,https://pubmed.ncbi.nlm.nih.gov/40725187/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTWD2,ENSG00000169570,Unsafe,40770106,RNA N-glycosylation enables immune evasion and homeostatic efferocytosis.,2025,10.1038/s41586-025-09310-6,https://pubmed.ncbi.nlm.nih.gov/40770106/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTWD2,ENSG00000169570,Unsafe,40722386,Detection of LUAD-Associated Genes Using Wasserstein Distance in Multiomics Feature Selection.,2025,10.3390/bioengineering12070694,https://pubmed.ncbi.nlm.nih.gov/40722386/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTWD2,ENSG00000169570,Unsafe,39885687,Trans-ancestry genome-wide association study of childhood body mass index identifies novel loci and age-specific effects.,2025,10.1016/j.xhgg.2025.100411,https://pubmed.ncbi.nlm.nih.gov/39885687/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTWD2,ENSG00000169570,Unsafe,39511485,The genome landscape of the Xinglong buffalo.,2024,10.1186/s12864-024-10941-8,https://pubmed.ncbi.nlm.nih.gov/39511485/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTWD2,ENSG00000169570,Unsafe,31804502,Biogenesis and functions of aminocarboxypropyluridine in tRNA.,2019,10.1038/s41467-019-13525-3,https://pubmed.ncbi.nlm.nih.gov/31804502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTWD2,ENSG00000169570,Unsafe,35116456,"KRAS, YWHAE, SP1 and MSRA as biomarkers in endometrial cancer.",2021,10.21037/tcr-20-2969,https://pubmed.ncbi.nlm.nih.gov/35116456/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTWD2,ENSG00000169570,Unsafe,33807835,Genome-Wide Association Study Identifies Eight Novel Loci for Susceptibility of Scrub Typhus and Highlights Immune-Related Signaling Pathways in Its Pathogenesis.,2021,10.3390/cells10030570,https://pubmed.ncbi.nlm.nih.gov/33807835/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTWD2,ENSG00000169570,Unsafe,33253256,"Identification of the enzymes responsible for m2,2G and acp3U formation on cytosolic tRNA from insects and plants.",2020,10.1371/journal.pone.0242737,https://pubmed.ncbi.nlm.nih.gov/33253256/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTWD2,ENSG00000169570,Unsafe,23953852,Genome-wide association studies of maximum number of drinks.,2013,10.1016/j.jpsychires.2013.07.013,https://pubmed.ncbi.nlm.nih.gov/23953852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTWD2,ENSG00000169570,Unsafe,20824097,Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.,2010,10.1371/journal.ppat.1001088,https://pubmed.ncbi.nlm.nih.gov/20824097/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DTWD2,ENSG00000169570,Unsafe,21310917,Copy number variations and primary open-angle glaucoma.,2011,10.1167/iovs.10-5606,https://pubmed.ncbi.nlm.nih.gov/21310917/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUSP19,ENSG00000162999,Unsafe,42144937,A novel tetramethylpyrazine derivative inhibits thyroid cancer progression by epigenetically activating the DUSP19-mediated JNK signaling pathway.,2026,10.3724/abbs.2026022,https://pubmed.ncbi.nlm.nih.gov/42144937/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUSP19,ENSG00000162999,Unsafe,42798001,Genome-Wide Association Studies Reveal Key Candidate Genes for Egg Weight and Quality Components in an F&lt;sub&gt;2&lt;/sub&gt; Japanese Quail Resource Population.,2026,10.3390/vetsci13090967,https://pubmed.ncbi.nlm.nih.gov/42798001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUSP19,ENSG00000162999,Unsafe,36336681,PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation.,2022,10.1186/s12929-022-00875-2,https://pubmed.ncbi.nlm.nih.gov/36336681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUSP19,ENSG00000162999,Unsafe,31813339,DUSP19 mediates spinal cord injury-induced apoptosis and inflammation in mouse primary microglia cells via the NF-kB signaling pathway.,2020,10.1080/01616412.2019.1685068,https://pubmed.ncbi.nlm.nih.gov/31813339/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUSP19,ENSG00000162999,Unsafe,33770577,Circ_HIPK3 alleviates CoCl2-induced apoptotic injury in neuronal cells by depending on the regulation of the miR-222-3p/DUSP19 axis.,2021,10.1016/j.bbrc.2021.03.070,https://pubmed.ncbi.nlm.nih.gov/33770577/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUSP19,ENSG00000162999,Unsafe,37980162,"Crucial role of hsa-mir-503, hsa-mir-1247, and their validation in prostate cancer.",2023,10.18632/aging.205213,https://pubmed.ncbi.nlm.nih.gov/37980162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUSP19,ENSG00000162999,Unsafe,29174854,DUSP19 regulates IL-1β-induced apoptosis and MMPs expression in rat chondrocytes through JAK2/STAT3 signaling pathway.,2017,10.1016/j.biopha.2017.11.097,https://pubmed.ncbi.nlm.nih.gov/29174854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUSP19,ENSG00000162999,Unsafe,26751999,"DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis.",2016,10.1039/c5mb00776c,https://pubmed.ncbi.nlm.nih.gov/26751999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUSP19,ENSG00000162999,Unsafe,11959862,"Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway.",2002,10.1074/jbc.m200838200,https://pubmed.ncbi.nlm.nih.gov/11959862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DUSP19,ENSG00000162999,Unsafe,12479873,"Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3.",2003,10.1016/s1357-2725(02)00127-9,https://pubmed.ncbi.nlm.nih.gov/12479873/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,36973253,Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity.,2023,10.1038/s41467-023-37370-7,https://pubmed.ncbi.nlm.nih.gov/36973253/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,40432967,"Identification and bioinformatics analysis of cilia-associated gene families in &lt;i&gt;Euplotes amieti&lt;/i&gt; (Ciliophora, Hypotrichia).",2025,10.3389/fmicb.2025.1486189,https://pubmed.ncbi.nlm.nih.gov/40432967/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,42861980,Temporal dissection of hepatitis C virus and orthoflavivirus infections by continuous luminescence monitoring.,2026,10.1128/jvi.01266-26,https://pubmed.ncbi.nlm.nih.gov/42861980/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,38908233,LncRNA DYNLRB2-AS1 promotes gemcitabine resistance of nasopharyngeal carcinoma by inhibiting the ubiquitination degradation of DHX9 protein.,2024,10.1016/j.drup.2024.101111,https://pubmed.ncbi.nlm.nih.gov/38908233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,41491239,CRISPR knockout screens reveal genes and pathways essential for neuronal differentiation and implicate PEDS1 in neurodevelopment.,2026,10.1038/s41593-025-02165-0,https://pubmed.ncbi.nlm.nih.gov/41491239/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,41651028,VPA targets Mid1 to improve disrupted retrograde axonal transport in hippocampal neurons and alleviate lithium manganate-induced learning and memory dysfunction.,2026,10.1016/j.jare.2026.01.081,https://pubmed.ncbi.nlm.nih.gov/41651028/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,41300787,Genome-Wide Association Study of First-Parity Reproductive Traits in Suzi Pig.,2025,10.3390/genes16111335,https://pubmed.ncbi.nlm.nih.gov/41300787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,40457613,Genome-Wide Association Analyses in Family Triads and Dyads Following Assisted Reproductive Technology.,2025,10.1002/gepi.70011,https://pubmed.ncbi.nlm.nih.gov/40457613/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,33717590,Bioinformatics and integrated analyses of prognosis-associated key genes in lung adenocarcinoma.,2021,10.21037/jtd-21-49,https://pubmed.ncbi.nlm.nih.gov/33717590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,33980598,Dynein Light-Chain Dynlrb2 Is Essential for Murine Leukemia Virus Traffic and Nuclear Entry.,2021,10.1128/jvi.00170-21,https://pubmed.ncbi.nlm.nih.gov/33980598/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,35637434,Key gene network related to primary ciliary dyskinesia in hippocampus of patients with Alzheimer's disease revealed by weighted gene co-expression network analysis.,2022,10.1186/s12883-022-02724-z,https://pubmed.ncbi.nlm.nih.gov/35637434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,40282202,Genetic Structure and Selection Signals for Extreme Environment Adaptation in &lt;i&gt;Lop Sheep&lt;/i&gt; of Xinjiang.,2025,10.3390/biology14040337,https://pubmed.ncbi.nlm.nih.gov/40282202/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,33545111,Recent advances in the regulation of ABCA1 and ABCG1 by lncRNAs.,2021,10.1016/j.cca.2021.01.019,https://pubmed.ncbi.nlm.nih.gov/33545111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,30649997,Interactions of the dynein-2 intermediate chain WDR34 with the light chains are required for ciliary retrograde protein trafficking.,2019,10.1091/mbc.e18-10-0678,https://pubmed.ncbi.nlm.nih.gov/30649997/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,28815701,LincRNA DYN-LRB2-2 upregulates cholesterol efflux by decreasing TLR2 expression in macrophages.,2018,10.1002/jcb.26352,https://pubmed.ncbi.nlm.nih.gov/28815701/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,33532314,Integrative bioinformatics approaches for identifying potential biomarkers and pathways involved in non-obstructive azoospermia.,2021,10.21037/tau-20-1029,https://pubmed.ncbi.nlm.nih.gov/33532314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,28250122,Functional Evidence of the Involvement of the Dynein Light Chain DYNLRB2 in Murine Leukemia Virus Infection.,2017,10.1128/jvi.00129-17,https://pubmed.ncbi.nlm.nih.gov/28250122/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,29576888,Long Non-coding RNA in Liver Metabolism and Disease: Current Status.,2017,10.1016/j.livres.2017.09.001,https://pubmed.ncbi.nlm.nih.gov/29576888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,30166060,"Development of xeno-free epithelial differentiation media for adherent, non-expanded adipose stromal vascular cell cultures.",2018,10.1016/j.bbrc.2018.08.104,https://pubmed.ncbi.nlm.nih.gov/30166060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,24493833,A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis.,2014,10.1194/jlr.m044669,https://pubmed.ncbi.nlm.nih.gov/24493833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,11750132,"Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients.",2001,10.1016/s0378-1119(01)00787-9,https://pubmed.ncbi.nlm.nih.gov/11750132/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,22887771,Differential copy number aberrations in novel candidate genes associated with progression from in situ to invasive ductal carcinoma of the breast.,2012,10.1002/gcc.21991,https://pubmed.ncbi.nlm.nih.gov/22887771/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,25205765,Subunit composition of the human cytoplasmic dynein-2 complex.,2014,10.1242/jcs.159038,https://pubmed.ncbi.nlm.nih.gov/25205765/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,22239941,A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians.,2012,10.1186/1471-2350-13-5,https://pubmed.ncbi.nlm.nih.gov/22239941/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,23221970,In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in mice.,2013,10.1289/ehp.1205590,https://pubmed.ncbi.nlm.nih.gov/23221970/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,20480226,Gene expression profiling of response to mTOR inhibitor everolimus in pre-operatively treated post-menopausal women with oestrogen receptor-positive breast cancer.,2010,10.1007/s10549-010-0928-6,https://pubmed.ncbi.nlm.nih.gov/20480226/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLRB2,ENSG00000168589,Unsafe,19711352,Requirement of a dynein light chain in TGFbeta/Smad3 signaling.,2009,10.1002/jcp.21910,https://pubmed.ncbi.nlm.nih.gov/19711352/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLT2,ENSG00000184786,Unsafe,40649876,Age-Associated Proteomic Changes in Human Spermatozoa.,2025,10.3390/ijms26136099,https://pubmed.ncbi.nlm.nih.gov/40649876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLT2,ENSG00000184786,Unsafe,32749594,Study of Linc00574 Regulatory Effect on the TCTE3 Expression in Sperm Motility.,2021,10.1007/s43032-020-00275-7,https://pubmed.ncbi.nlm.nih.gov/32749594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLT2,ENSG00000184786,Unsafe,29079176,T-complex-associated-testis-expressed 3 (TCTE3) is a novel marker for pancreatobiliary carcinomas.,2017,10.1016/j.humpath.2017.10.010,https://pubmed.ncbi.nlm.nih.gov/29079176/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLT2,ENSG00000184786,Unsafe,34803456,Analyzing differentially expressed genes and pathways of Bex2-deficient mouse lung via RNA-Seq.,2021,10.3906/biy-2104-4,https://pubmed.ncbi.nlm.nih.gov/34803456/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLT2,ENSG00000184786,Unsafe,25462330,Disruption of murine Tcte3-3 induces tissue specific apoptosis via co-expression of Anxa5 and Pebp1.,2014,10.1016/j.compbiolchem.2014.10.005,https://pubmed.ncbi.nlm.nih.gov/25462330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLT2,ENSG00000184786,Unsafe,19778998,Disruption of the murine dynein light chain gene Tcte3-3 results in asthenozoospermia.,2010,10.1530/rep-09-0243,https://pubmed.ncbi.nlm.nih.gov/19778998/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLT2,ENSG00000184786,Unsafe,21085971,Identification of TCTE3 as a gene responsible for congenital diaphragmatic hernia using a high-resolution single-nucleotide polymorphism array.,2011,10.1007/s00383-010-2778-z,https://pubmed.ncbi.nlm.nih.gov/21085971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLT2,ENSG00000184786,Unsafe,26643481,Search for Rare Copy-Number Variants in Congenital Heart Defects Identifies Novel Candidate Genes and a Potential Role for FOXC1 in Patients With Coarctation of the Aorta.,2016,10.1161/circgenetics.115.001213,https://pubmed.ncbi.nlm.nih.gov/26643481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLT2,ENSG00000184786,Unsafe,12584439,Identification of the human ortholog of the t-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia.,2002,10.1159/000068545,https://pubmed.ncbi.nlm.nih.gov/12584439/,annotation citations | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLT2,ENSG00000184786,Unsafe,21980299,A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.,2011,10.1371/journal.pgen.1002293,https://pubmed.ncbi.nlm.nih.gov/21980299/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYNLT2,ENSG00000184786,Unsafe,11278908,"The Tctex1/Tctex2 class of dynein light chains. Dimerization, differential expression, and interaction with the LC8 protein family.",2001,10.1074/jbc.m011456200,https://pubmed.ncbi.nlm.nih.gov/11278908/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,42123737,"Correction: Huang et al. PAICS/DYRK3 Multienzyme Interactions as Coregulators of Purinosome Formation and Metabolism on Radioresistance in Oral Squamous Cell Carcinoma. &lt;i&gt;Int. J. Mol. Sci.&lt;/i&gt; 2023, &lt;i&gt;24&lt;/i&gt;, 17346.",2026,10.3390/ijms27094007,https://pubmed.ncbi.nlm.nih.gov/42123737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,40841441,"Kinase activity of DYRK family members is required for regulating primary cilium length, stability and morphology.",2025,10.1038/s42003-025-08373-5,https://pubmed.ncbi.nlm.nih.gov/40841441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,41325334,Potential phosphorylation of Liprin-α1 at threonine 701 regulates integrin-mediated cell motility.,2025,10.1371/journal.pone.0337621,https://pubmed.ncbi.nlm.nih.gov/41325334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,40904174,Unveiling the biophysical basis of DYRK kinase family isoform selectivity mechanism of Abemaciclib using computational approaches.,2025,10.1080/1062936x.2025.2552133,https://pubmed.ncbi.nlm.nih.gov/40904174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,38139175,PAICS/DYRK3 Multienzyme Interactions as Coregulators of Purinosome Formation and Metabolism on Radioresistance in Oral Squamous Cell Carcinoma.,2023,10.3390/ijms242417346,https://pubmed.ncbi.nlm.nih.gov/38139175/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,42510829,MEK1 as a Synthetic Lethal Target with Cabozantinib in Renal Cell Carcinoma: Insights from CRISPR/Cas9 Screening.,2026,10.3390/genes17070789,https://pubmed.ncbi.nlm.nih.gov/42510829/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,38519031,Dual-specificity kinase DYRK3 phosphorylates p62 at the Thr-269 residue and promotes melanoma progression.,2024,10.1016/j.jbc.2024.107206,https://pubmed.ncbi.nlm.nih.gov/38519031/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,41083636,MLE/DHX9 Helicase Activity Is Required to Regulate the Expression of a Number of Tissue-Specific Genes on Chromosome 4 in Drosophila melanogaster.,2025,10.1134/s1607672925601222,https://pubmed.ncbi.nlm.nih.gov/41083636/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,38255303,A Novel Druggable Dual-Specificity tYrosine-Regulated Kinase3/Calmodulin Kinase-like Vesicle-Associated Signaling Module with Therapeutic Implications in Neuroblastoma.,2024,10.3390/biomedicines12010197,https://pubmed.ncbi.nlm.nih.gov/38255303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,38529261,Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 3 Expression and Its Correlation with Prognosis and Growth of Serous Ovarian Cancer: Correlation of DYRK3 with Ovarian Cancer Survival.,2024,10.1155/2024/6683202,https://pubmed.ncbi.nlm.nih.gov/38529261/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,38510137,Dual specificity kinase DYRK3 regulates cell migration by influencing the stability of protrusions.,2024,10.1016/j.isci.2024.109440,https://pubmed.ncbi.nlm.nih.gov/38510137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,40313599,Identification of diagnostic biomarkers for fibromyalgia using gene expression analysis and machine learning.,2025,10.3389/fgene.2025.1535541,https://pubmed.ncbi.nlm.nih.gov/40313599/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,36585413,DYRK3 phosphorylates SNAPIN to regulate axonal retrograde transport and neurotransmitter release.,2022,10.1038/s41420-022-01290-0,https://pubmed.ncbi.nlm.nih.gov/36585413/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,40136443,Unravelling Convergent Signaling Mechanisms Underlying the Aging-Disease Nexus Using Computational Language Analysis.,2025,10.3390/cimb47030189,https://pubmed.ncbi.nlm.nih.gov/40136443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,40279414,Protecting centrosomes from fracturing enables efficient cell navigation.,2025,10.1126/sciadv.adx4047,https://pubmed.ncbi.nlm.nih.gov/40279414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,36161154,Roles of dual specificity tyrosine-phosphorylation-regulated kinase 2 in nervous system development and disease.,2022,10.3389/fnins.2022.994256,https://pubmed.ncbi.nlm.nih.gov/36161154/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,41072140,Identification of novel gene fusions in high-grade serous ovarian carcinoma: implications for tumorigenesis and targeted therapy.,2025,10.1016/j.cancergen.2025.09.012,https://pubmed.ncbi.nlm.nih.gov/41072140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,38994142,Hepatocellular carcinoma: An analysis of the expression status of stress granules and their prognostic value.,2024,10.4251/wjgo.v16.i6.2571,https://pubmed.ncbi.nlm.nih.gov/38994142/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,38398225,"The Nitro Group Reshapes the Effects of Pyrido[3,4-g]quinazoline Derivatives on DYRK/CLK Activity and RNA Splicing in Glioblastoma Cells.",2024,10.3390/cancers16040834,https://pubmed.ncbi.nlm.nih.gov/38398225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,33738926,Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling.,2021,10.15252/embr.202051740,https://pubmed.ncbi.nlm.nih.gov/33738926/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,38556169,Assessment of Kinome-Wide Activity Remodeling upon Picornavirus Infection.,2024,10.1016/j.mcpro.2024.100757,https://pubmed.ncbi.nlm.nih.gov/38556169/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,35801486,"Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors.",2022,10.1080/14756366.2022.2096019,https://pubmed.ncbi.nlm.nih.gov/35801486/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,35454940,A Bioinformatics Evaluation of the Role of Dual-Specificity Tyrosine-Regulated Kinases in Colorectal Cancer.,2022,10.3390/cancers14082034,https://pubmed.ncbi.nlm.nih.gov/35454940/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,38571892,Mesenchymal stem cells reverse thymus aging by reprogramming the DNA methylation of thymic epithelial cells.,2024,10.1016/j.reth.2024.03.008,https://pubmed.ncbi.nlm.nih.gov/38571892/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,35875157,"P-Rex1 Signaling Hub in Lower Grade Glioma Patients, Found by In Silico Data Mining, Correlates With Reduced Survival and Augmented Immune Tumor Microenvironment.",2022,10.3389/fonc.2022.922025,https://pubmed.ncbi.nlm.nih.gov/35875157/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,31470564,Membrane-Bound Meet Membraneless in Health and Disease.,2019,10.3390/cells8091000,https://pubmed.ncbi.nlm.nih.gov/31470564/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,27641670,Identification of early gene expression changes in primary cultured neurons treated with topoisomerase I poisons.,2016,10.1016/j.bbrc.2016.09.068,https://pubmed.ncbi.nlm.nih.gov/27641670/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,23805279,Identification of Host Kinase Genes Required for Influenza Virus Replication and the Regulatory Role of MicroRNAs.,2013,10.1371/journal.pone.0066796,https://pubmed.ncbi.nlm.nih.gov/23805279/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,18367224,Chromosomal changes in high- and low-invasive mouse lung adenocarcinoma cell strains derived from early passage mouse lung adenocarcinoma cell strains.,2008,10.1016/j.taap.2008.01.031,https://pubmed.ncbi.nlm.nih.gov/18367224/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DYRK3,ENSG00000143479,Unsafe,10779429,"REDK, a novel human regulatory erythroid kinase.",2000,10.1182/blood.v95.9.2838.009k29_2838_2846,https://pubmed.ncbi.nlm.nih.gov/10779429/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,41566533,OCTN2 Activates a Non-Canonical Carnitine Metabolic Pathway to Promote MASH-HCC Progression and Immunotherapy Resistance.,2026,10.1002/advs.202517054,https://pubmed.ncbi.nlm.nih.gov/41566533/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,42486810,Self-Splicing RNA Platform Encodes Twin PROTACs for Dual-E3 Ligase Recruitment and Programmable Protein Degradation.,2026,10.1021/jacs.6c11759,https://pubmed.ncbi.nlm.nih.gov/42486810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,36841324,Proteomic analysis of DZIP3 interactome and its role in proliferation and metastasis in gastric cancer cells.,2023,10.1016/j.yexcr.2023.113525,https://pubmed.ncbi.nlm.nih.gov/36841324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,40626177,&lt;i&gt;CYLD&lt;/i&gt; as a key regulator of myocardial infarction-to-heart failure transition revealed by multi-omics integration.,2025,10.3389/fgene.2025.1592985,https://pubmed.ncbi.nlm.nih.gov/40626177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,33067265,RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression.,2021,10.1158/0008-5472.can-20-1871,https://pubmed.ncbi.nlm.nih.gov/33067265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,33229627,DZIP3 is a key factor to stratify IDH1 wild-type lower-grade gliomas.,2020,10.18632/aging.103817,https://pubmed.ncbi.nlm.nih.gov/33229627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,33330022,Blood Cell DNA Methylation of Aging-Related Ubiquitination Gene DZIP3 Can Predict the Onset of Early Stage Colorectal Cancer.,2020,10.3389/fonc.2020.544330,https://pubmed.ncbi.nlm.nih.gov/33330022/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,35993275,The A to I editing landscape in melanoma and its relation to clinical outcome.,2022,10.1080/15476286.2022.2110390,https://pubmed.ncbi.nlm.nih.gov/35993275/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,29812999,Generation of Rat Monoclonal Antibodies Specific for DZIP3.,2018,10.1089/mab.2018.0005,https://pubmed.ncbi.nlm.nih.gov/29812999/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,32796072,GBP5 Is an Interferon-Induced Inhibitor of Respiratory Syncytial Virus.,2020,10.1128/jvi.01407-20,https://pubmed.ncbi.nlm.nih.gov/32796072/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,36351462,"A high-quality, haplotype-phased genome reconstruction reveals unexpected haplotype diversity in a pearl oyster.",2022,10.1093/dnares/dsac035,https://pubmed.ncbi.nlm.nih.gov/36351462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,26505218,"Novel CARM1-Interacting Protein, DZIP3, Is a Transcriptional Coactivator of Estrogen Receptor-α.",2015,10.1210/me.2015-1083,https://pubmed.ncbi.nlm.nih.gov/26505218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,31448224,Transcriptomic Analysis Identifies RNA Binding Proteins as Putative Regulators of Myelopoiesis and Leukemia.,2019,10.3389/fonc.2019.00692,https://pubmed.ncbi.nlm.nih.gov/31448224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,31099175,Genome-wide association study identifies loci associated with liability to alcohol and drug dependence that is associated with variability in reward-related ventral striatum activity in African- and European-Americans.,2019,10.1111/gbb.12580,https://pubmed.ncbi.nlm.nih.gov/31099175/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,26568260,Dzip3 regulates developmental genes in mouse embryonic stem cells by reorganizing 3D chromatin conformation.,2015,10.1038/srep16567,https://pubmed.ncbi.nlm.nih.gov/26568260/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,24326307,Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination.,2013,10.1038/ncomms3939,https://pubmed.ncbi.nlm.nih.gov/24326307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,27249653,Establishment of a Wheat Cell-Free Synthesized Protein Array Containing 250 Human and Mouse E3 Ubiquitin Ligases to Identify Novel Interaction between E3 Ligases and Substrate Proteins.,2016,10.1371/journal.pone.0156718,https://pubmed.ncbi.nlm.nih.gov/27249653/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,25926359,ATRX contributes to epigenetic asymmetry and silencing of major satellite transcripts in the maternal genome of the mouse embryo.,2015,10.1242/dev.118927,https://pubmed.ncbi.nlm.nih.gov/25926359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
DZIP3,ENSG00000198919,Unsafe,12538761,"hRUL138, a novel human RNA-binding RING-H2 ubiquitin-protein ligase.",2003,10.1242/jcs.00261,https://pubmed.ncbi.nlm.nih.gov/12538761/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,42528732,Bioinformatics-driven single-cell sequencing analysis of angiogenesis-related genes in rheumatoid arthritis.,2026,10.3389/fimmu.2026.1789899,https://pubmed.ncbi.nlm.nih.gov/42528732/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,42754577,E2F7 promotes lung adenocarcinoma progression by affecting phosphorylation and stabilization of β-catenin.,2026,10.1097/cm9.0000000000004312,https://pubmed.ncbi.nlm.nih.gov/42754577/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,42919175,EIF3B is associated with m&lt;sup&gt;6&lt;/sup&gt;A-related regulation of E2F7 and promotes stemness in glioblastoma multiforme.,2026,10.1186/s12885-026-16552-8,https://pubmed.ncbi.nlm.nih.gov/42919175/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,42001349,Correlation between E2F7 overexpression and immune infiltration in lung adenocarcinoma.,2026,10.1007/s12672-026-04966-6,https://pubmed.ncbi.nlm.nih.gov/42001349/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,41327220,E2F7 promotes ESCC progression and cisplatin resistance through transcriptional activation of DVL3 and the Wnt signaling pathway.,2025,10.1186/s12957-025-04113-5,https://pubmed.ncbi.nlm.nih.gov/41327220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,42309715,MicroRNA-195-5p/E2F7 Axis Underlies the Antimicrobial Additive Triclosan-Induced Cytotoxicity in Human Pulmonary Epithelial Cells.,2026,10.1002/jat.70290,https://pubmed.ncbi.nlm.nih.gov/42309715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,41454190,High E2F7 Expression Indicates Pancreatic Cancer Aggressiveness and Downregulation of E2F7 Enhances Sensitivity to S-1.,2026,10.1245/s10434-025-18912-3,https://pubmed.ncbi.nlm.nih.gov/41454190/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,41649784,ASO Visual Abstract: High E2F7 Expression Indicates Pancreatic Cancer Aggressiveness and Downregulation of E2F7 Enhances Sensitivity to S-1.,2026,10.1245/s10434-026-19134-x,https://pubmed.ncbi.nlm.nih.gov/41649784/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,42119232,Tumor cell-derived exosomal E2F7 promotes colorectal cancer progression by interacting with SMC4 and induced macrophage M2 polarization.,2026,10.1016/j.intimp.2026.116846,https://pubmed.ncbi.nlm.nih.gov/42119232/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,42584853,Cdk1 and PP2A constitute a molecular switch controlling orderly degradation of atypical E2Fs.,2026,10.1091/mbc.e26-07-0323,https://pubmed.ncbi.nlm.nih.gov/42584853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,40116212,Ascending E2F7a/b ratio facilitates KLF13 transcription in hepatocellular carcinoma and correlates with the abundance of binuclear hepatocytes (ABH) modulation for short-term recurrence.,2025,10.1096/fj.202402520r,https://pubmed.ncbi.nlm.nih.gov/40116212/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,41050080,Competitive Sequestration of miR-1183 by lncRNA DDX11-AS1 Drives Gliomagenesis through E2F7 Activation.,2025,10.32604/or.2025.065380,https://pubmed.ncbi.nlm.nih.gov/41050080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,41401899,miR-15b-5p impairs myelin repair and cognitive recovery after ischemic stroke by targeting the E2F7/CXCL2 axis.,2026,10.1016/j.expneurol.2025.115589,https://pubmed.ncbi.nlm.nih.gov/41401899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,42026967,XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia.,2026,10.1080/16078454.2026.2664314,https://pubmed.ncbi.nlm.nih.gov/42026967/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,41633994,Diploid hepatocytes resist acetaminophen-induced liver injury through suppressed JNK signaling.,2026,10.1038/s41419-026-08448-z,https://pubmed.ncbi.nlm.nih.gov/41633994/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,41555104,E2F7 targets S100A2 to suppress CD8&lt;sup&gt;+&lt;/sup&gt;T cell activity in lung adenocarcinoma by regulating glutamine metabolism.,2026,10.1007/s00109-026-02637-1,https://pubmed.ncbi.nlm.nih.gov/41555104/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,41821249,MiR-10a-5p aggravates podocyte injury in diabetic nephropathy by inhibiting E2f7-mediated autophagy.,2026,10.1111/dme.70270,https://pubmed.ncbi.nlm.nih.gov/41821249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,40407049,Suppression of pseudogene MT2P1 transcription induced by E2F7 inhibits hepatocellular carcinoma cell proliferation and facilitates apoptosis via preserving its parental gene.,2025,10.1080/15384047.2025.2510035,https://pubmed.ncbi.nlm.nih.gov/40407049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,41052139,E2F7/Beclin-1 Pathway: Influencing Autophagy and EMT in ccRCC.,2025,10.1097/pai.0000000000001288,https://pubmed.ncbi.nlm.nih.gov/41052139/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,41640972,Single-cell RNA sequencing revealed cell heterogeneity in sagittal suture mesenchyme.,2026,10.3389/fcell.2026.1725375,https://pubmed.ncbi.nlm.nih.gov/41640972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,42429187,Non-Invasive Transdermal Delivery of miR-30a-5p via MUC1-Aptamer-Guided Tetrahedral DNA Nanostructures for Gene Silencing in Cutaneous Melanoma.,2026,10.1002/smll.74557,https://pubmed.ncbi.nlm.nih.gov/42429187/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,42702761,Single-Cell Transcriptome of Anaplastic Thyroid Cancer Reveals Immunosuppressive Tumor Microenvironment Remodeling.,2026,10.1002/cam4.72261,https://pubmed.ncbi.nlm.nih.gov/42702761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,41372399,E2F transcription factors as multimodal biomarkers for pan-cancer management.,2025,10.1038/s41598-025-31042-w,https://pubmed.ncbi.nlm.nih.gov/41372399/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,41110842,Arsenic Induces Cytotoxicity in Pulmonary Epithelial Cells by Regulating the MicroRNA-195-5p/E2F7 Axis: The Impact of Tannic Acid From Natural Sources.,2026,10.1002/jat.4964,https://pubmed.ncbi.nlm.nih.gov/41110842/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,38905387,The predictive value of E2F7 in immunotherapy efficacy for lung adenocarcinoma: An observational study.,2024,10.1097/md.0000000000038574,https://pubmed.ncbi.nlm.nih.gov/38905387/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,38073330,Transcription Factor E2F7 Hampers the Killing Effect of NK Cells against Colorectal Cancer Cells via Activating RAD18 Transcription.,2024,10.4014/jmb.2308.08026,https://pubmed.ncbi.nlm.nih.gov/38073330/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,38760774,Integrated analysis reveals critical cisplatin-resistance regulators E2F7 contributed to tumor progression and metastasis in lung adenocarcinoma.,2024,10.1186/s12935-024-03366-6,https://pubmed.ncbi.nlm.nih.gov/38760774/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,40133626,Targeting the HuR/E2F7 axis synergizes with bortezomib against multiple myeloma.,2025,10.1038/s41401-025-01529-3,https://pubmed.ncbi.nlm.nih.gov/40133626/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,39613162,"E2F1 and E2F7 regulate gastric cancer cell proliferation, respectively, through transcriptional activation and transcriptional repression of MYBL2.",2025,10.1016/j.jbc.2024.108027,https://pubmed.ncbi.nlm.nih.gov/39613162/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,40026193,EFL-3/E2F7 modulates Wnt signalling by repressing the Nemo-like kinase LIT-1 during asymmetric epidermal cell division in Caenorhabditis elegans.,2025,10.1242/dev.204546,https://pubmed.ncbi.nlm.nih.gov/40026193/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,40025145,Screening of common genomic biomarkers to explore common drugs for the treatment of pancreatic and kidney cancers with type-2 diabetes through bioinformatics analysis.,2025,10.1038/s41598-025-91875-3,https://pubmed.ncbi.nlm.nih.gov/40025145/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,39959839,Integrated genomic analysis of the stemness index signature of mRNA expression predicts lung adenocarcinoma prognosis and immune landscape.,2025,10.7717/peerj.18945,https://pubmed.ncbi.nlm.nih.gov/39959839/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
E2F7,ENSG00000165891,Unsafe,38241554,E2F7 serves as a potential prognostic biomarker for lung adenocarcinoma.,2024,10.1097/md.0000000000034342,https://pubmed.ncbi.nlm.nih.gov/38241554/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,42712571,Shifting the paradigm in bipolar disorder: moving beyond conventional inflammatory markers to novel EBI3-containing heterodimeric cytokines.,2026,10.3389/fpsyt.2026.1759397,https://pubmed.ncbi.nlm.nih.gov/42712571/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,42577052,Free Epstein-Barr virus-induced gene 3 functions as an autonomous immunosuppressive cytokine to maintain immune tolerance.,2026,10.3389/fimmu.2026.1858675,https://pubmed.ncbi.nlm.nih.gov/42577052/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,41615190,"Genetic variants of EBI3, tumor Epstein-Barr virus, and human cytomegalovirus status in HPV-negative oral cancer.",2026,10.1590/1678-7765-2025-0492,https://pubmed.ncbi.nlm.nih.gov/41615190/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,41904509,Chemotherapy-induced senescent nasopharyngeal carcinoma cells suppress NK cell-mediated antitumor immunity by upregulating EBI3 via mtDNA-cGAS-STING pathway.,2026,10.1186/s12964-026-02848-6,https://pubmed.ncbi.nlm.nih.gov/41904509/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,42235085,Human neutrophilic cells express anti-inflammatory EBI3 in response to Neisseria meningitidis.,2026,10.1016/j.jneuroim.2026.578995,https://pubmed.ncbi.nlm.nih.gov/42235085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,42792776,Discordant Interleukin-27 (IL-27) Subunit Transcription in Human Sepsis Exposes a Molecular-Attribution Gap.,2026,10.3390/biomedicines14092035,https://pubmed.ncbi.nlm.nih.gov/42792776/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,42607975,Two functional Il-35 molecules negatively regulate Ifn-γ-induced macrophage immune responses in large yellow croaker (Larimichthys crocea).,2026,10.1016/j.fsi.2026.111661,https://pubmed.ncbi.nlm.nih.gov/42607975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,42835505,Dynamic regulation of hypoxia-associated regulatory CD39&lt;sup&gt;+&lt;/sup&gt;CD73&lt;sup&gt;+&lt;/sup&gt; and IL35&lt;sup&gt;+&lt;/sup&gt; B cells in pancreatic cancer.,2026,10.3389/fimmu.2026.1814123,https://pubmed.ncbi.nlm.nih.gov/42835505/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,42910842,Interleukin-35 Ameliorates Obesity-Associated Impairment of Endothelium-Dependent Vasodilation via the STAT3-MAPK/ERK-eNOS Signaling Axis.,2026,10.1002/iid3.70564,https://pubmed.ncbi.nlm.nih.gov/42910842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,40889276,Tumor-Derived EBI3 Promotes CD8+ T-cell Exhaustion via STAT4-IL10/CCL5 in Gastric Cancer.,2025,10.1158/2326-6066.cir-24-1228,https://pubmed.ncbi.nlm.nih.gov/40889276/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,41722716,Elevated IL-27 and altered anti-inflammatory cytokine levels in SLE patients with end-stage renal disease.,2026,10.1016/j.clinbiochem.2026.111106,https://pubmed.ncbi.nlm.nih.gov/41722716/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,41346623,The recombinant IL-35 and anti-Ebi3 antibody administration before implantation modulate immune regulation and fetal outcomes in an abortion-prone mouse model.,2025,10.3389/fimmu.2025.1648641,https://pubmed.ncbi.nlm.nih.gov/41346623/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,40696294,The expression and clinical significance of IL-27 and Foxp3 in oral squamous cell carcinoma.,2025,10.1186/s12885-025-14597-9,https://pubmed.ncbi.nlm.nih.gov/40696294/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,40264784,High interleukin-35 expression is associated with the severity of rheumatic mitral stenosis.,2025,10.3389/fimmu.2025.1537497,https://pubmed.ncbi.nlm.nih.gov/40264784/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,39699043,Potential Role of EBI3 in Gastric Cancer and Its Inductive Effects on T-Cell Exhaustion.,2025,10.1097/xcs.0000000000001263,https://pubmed.ncbi.nlm.nih.gov/39699043/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,39726752,Malignant behaviors and immune response in melanoma: Epstein-Barr virus induced gene 3 as a therapeutic target based on an &lt;i&gt;in-vitro&lt;/i&gt; exploration.,2024,10.7717/peerj.18730,https://pubmed.ncbi.nlm.nih.gov/39726752/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,41357575,Suppression of NK cell-mediated immunosurveillance by IL-35 drives tumor progression in EGFR-mutant non-small cell lung cancer.,2025,10.3389/fonc.2025.1692801,https://pubmed.ncbi.nlm.nih.gov/41357575/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,40483561,Altered Serum IL-35 Levels and IL-37 Gene Expression in Patients with Parkinson's Disease: Focus on Emerging Cytokines.,2025,10.22034/iji.2025.105508.2955,https://pubmed.ncbi.nlm.nih.gov/40483561/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,42780496,Candidate proteomic indirect-effect signals linking dementia to probable muscle-bone fragility: a UK Biobank cohort study.,2026,10.3389/fmed.2026.1883046,https://pubmed.ncbi.nlm.nih.gov/42780496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,41666506,"scRNA-seq of preeclamptic trophoblasts identifies EBI3, COL17A1, miR-27a-5p, and miR-193b-5p as hypoxia markers: validation of neuradapt as a superior mimetic to cobalt chloride.",2026,10.1016/j.placenta.2026.02.005,https://pubmed.ncbi.nlm.nih.gov/41666506/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,42579941,Immunomodulatory effects of palm-derived tocotrienol-rich fraction in healthy volunteers following influenza vaccination: A randomised clinical trial.,2026,10.1016/j.nutres.2026.07.004,https://pubmed.ncbi.nlm.nih.gov/42579941/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,42034709,Profiling the tumor immunological status in Japanese solid cancers using the tumor immune status scoring algorithm.,2026,10.1038/s41598-026-50128-7,https://pubmed.ncbi.nlm.nih.gov/42034709/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,39240167,Ebi3 Binding to IFN-γ and IL-10 Limits Their Function.,2024,10.4049/jimmunol.2400236,https://pubmed.ncbi.nlm.nih.gov/39240167/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,39797931,Harnessing IL-27: challenges and potential in cancer immunotherapy.,2025,10.1007/s10238-025-01562-w,https://pubmed.ncbi.nlm.nih.gov/39797931/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,40743488,Unknown Immunoregulatory Effects of FcRn Inhibition by Efgartigimod in Myasthenia Gravis: A New Mechanism of Action Beyond IgG Reduction.,2025,10.1212/nxi.0000000000200455,https://pubmed.ncbi.nlm.nih.gov/40743488/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,40259042,Dendrobium huoshanense polysaccharide inhibits NSCLC proliferation and immune evasion via FXR1-IL-35 axis signaling pathway.,2025,10.1007/s11418-025-01894-7,https://pubmed.ncbi.nlm.nih.gov/40259042/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,38986251,Breakthroughs in road mapping IL-35 mediated immunotherapy for type-1 and autoimmune diabetes mellitus.,2024,10.1016/j.cyto.2024.156692,https://pubmed.ncbi.nlm.nih.gov/38986251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EBI3,ENSG00000105246,Unsafe,41151481,Malignant cell-mediated Treg immune suppression via ICOSLG-ICOS axis in tumor microenvironment relates to nasopharyngeal carcinoma prognosis.,2025,10.1016/j.intimp.2025.115743,https://pubmed.ncbi.nlm.nih.gov/41151481/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,42470274,Epithelial &lt;i&gt;Edar&lt;/i&gt; Is Responsible for Dental Anomalies in HED.,2026,10.1177/00220345261453329,https://pubmed.ncbi.nlm.nih.gov/42470274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,42378135,Association between genetic ancestry and EDAR rs3827760 genotypes in Latin American populations,2026,10.7705/biomedica.7693,https://pubmed.ncbi.nlm.nih.gov/42378135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,42708304,EDAR-Mediated Cell Fate Determination via the PGTM Network: A Potential Landscape Analysis.,2026,10.2174/0113862073486745260820114658,https://pubmed.ncbi.nlm.nih.gov/42708304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,42453607,The emergence of the ectodysplasin pathway.,2026,10.1515/biol-2025-1345,https://pubmed.ncbi.nlm.nih.gov/42453607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,42710936,"Selective advantages, selective mismatches, chronic inflammation, obesity, and type 2 diabetes: a new hypothesis to explain the effects of natural selection on genetic variation at the ectodysplasin A receptor locus.",2026,10.1136/bmjdrc-2026-005937,https://pubmed.ncbi.nlm.nih.gov/42710936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,40995667,Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR-NFκB Pathway.,2025,10.1002/advs.202506139,https://pubmed.ncbi.nlm.nih.gov/40995667/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,41188799,"Novel EDAR death domain variants in Thai patients with ectodermal dysplasia: clinical, molecular, and scoping review insights.",2025,10.1186/s12903-025-07103-x,https://pubmed.ncbi.nlm.nih.gov/41188799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,41645317,"Mutational spectrum of EDA, EDAR, EDARADD, and WNT10A genes in the largest cohort of Russian patients with hypohidrotic ectodermal dysplasia.",2026,10.1186/s13023-026-04211-x,https://pubmed.ncbi.nlm.nih.gov/41645317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,41872875,Multistage orthodontic-implantology-prosthetic treatment of a patient diagnosed with hypohidrosis ectodermal dysplasia syndrome with EDAR mutation: a case report.,2026,10.1186/s12903-026-08153-5,https://pubmed.ncbi.nlm.nih.gov/41872875/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,41833834,Roles of K-channel activity in feather bud morphogenesis.,2026,10.1016/j.ydbio.2026.03.005,https://pubmed.ncbi.nlm.nih.gov/41833834/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,42163948,Genetic Identification of Potential Drug Targets for Dental Caries: A Mendelian Randomization Study.,2026,10.1002/hsr2.72546,https://pubmed.ncbi.nlm.nih.gov/42163948/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,41408253,A case study of a novel homozygous EDAR splice site variant in hypohidrotic ectodermal dysplasia with tooth agenesis: molecular dynamics insights.,2025,10.1186/s12920-025-02300-7,https://pubmed.ncbi.nlm.nih.gov/41408253/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,42145183,Characterisation of human hair follicle development.,2026,10.1111/joa.70150,https://pubmed.ncbi.nlm.nih.gov/42145183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,42335782,Genomic and transcriptomic insights into color pigmentation variation in barred chickens.,2026,10.1016/j.psj.2026.107245,https://pubmed.ncbi.nlm.nih.gov/42335782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,41226524,Dissecting the Genetic Contribution of Tooth Agenesis.,2025,10.3390/ijms262110485,https://pubmed.ncbi.nlm.nih.gov/41226524/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,41120385,Fault tolerant and quality of service aware routing algorithm based on priority technique for scalable network on chip architectures.,2025,10.1038/s41598-025-20381-3,https://pubmed.ncbi.nlm.nih.gov/41120385/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,39685785,Critical Considerations in Calling Disease-Causing EDAR Mutations in Nonsyndromic Oligodontia.,2024,10.3390/jcm13237328,https://pubmed.ncbi.nlm.nih.gov/39685785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,41344457,Ectodysplasin A regulates the development of scale and intermuscular bone in teleosts.,2026,10.1016/j.ijbiomac.2025.149465,https://pubmed.ncbi.nlm.nih.gov/41344457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,38169761,Activation of wnt/β-catenin signaling pathway down regulated osteogenic differentiation of bone marrow-derived stem cells in an anhidrotic ectodermal dysplasia patient with EDA/EDAR/EDARADD mutation.,2024,10.1016/j.heliyon.2023.e23057,https://pubmed.ncbi.nlm.nih.gov/38169761/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,41187380,Novel missense mutations in the tumor necrosis factor domain of Ectodysplasin-A cause non-syndromic tooth agenesis in two Chinese families.,2026,10.1016/j.archoralbio.2025.106441,https://pubmed.ncbi.nlm.nih.gov/41187380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,41569281,Healthcare professionals' experiences and thoughts on eating and drinking with acknowledged risks in older adults: a comparison of Japan and the UK.,2026,10.1093/ageing/afaf380,https://pubmed.ncbi.nlm.nih.gov/41569281/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,40575186,Effectiveness of Six Sigma in Managing Medical Errors in the Electronic Drug Administration Record (EDAR) System.,2025,10.7759/cureus.84864,https://pubmed.ncbi.nlm.nih.gov/40575186/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,39537853,Eating and Drinking with Acknowledged Risks (EDAR) in Older Adults: A Qualitative Study of the Experiences of Clinicians in Japan and the UK.,2025,10.1007/s00455-024-10765-4,https://pubmed.ncbi.nlm.nih.gov/39537853/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,40484210,Multicenter Experience With the Unitary Stent Graft System for Endovascular Debranched Aortic Repair of Various Thoracoabdominal Aortopathies.,2025,10.1016/j.athoracsur.2025.05.026,https://pubmed.ncbi.nlm.nih.gov/40484210/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,42795424,"A &lt;i&gt;Bacillus pretiosus&lt;/i&gt; Biofertilizer Enhances Early Growth, Nutritional Profile, and Rhizospheric Dynamics in &lt;i&gt;Quercus&lt;/i&gt; Species for Forest Restoration.",2026,10.3390/life16091558,https://pubmed.ncbi.nlm.nih.gov/42795424/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,38722516,Decisions on eating and drinking in older adults admitted with pneumonia and referred for swallowing difficulties.,2024,10.1007/s41999-024-00983-2,https://pubmed.ncbi.nlm.nih.gov/38722516/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,36672894,Protocol for the Phase 2 EDELIFE Trial Investigating the Efficacy and Safety of Intra-Amniotic ER004 Administration to Male Subjects with X-Linked Hypohidrotic Ectodermal Dysplasia.,2023,10.3390/genes14010153,https://pubmed.ncbi.nlm.nih.gov/36672894/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,37739945,Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte.,2023,10.1038/s41419-023-06134-y,https://pubmed.ncbi.nlm.nih.gov/37739945/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,36230498,Clinical Presentation and Prognostic Features in Patients with Immunotherapy-Induced Vitiligo-like Depigmentation: A Monocentric Prospective Observational Study.,2022,10.3390/cancers14194576,https://pubmed.ncbi.nlm.nih.gov/36230498/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,38540700,Fine Wrinkle Improvement through Bioactive Materials That Modulate &lt;i&gt;EDAR&lt;/i&gt; and &lt;i&gt;BNC2&lt;/i&gt; Gene Expression.,2024,10.3390/biom14030279,https://pubmed.ncbi.nlm.nih.gov/38540700/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,35646897,miR-29a-5p Inhibits Prenatal Hair Placode Formation Through Targeting EDAR by ceRNA Regulatory Network.,2022,10.3389/fcell.2022.902026,https://pubmed.ncbi.nlm.nih.gov/35646897/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,38023809,Molecular basis and genetics of hypohidrotic ectodermal dysplasias.,2023,10.18699/vjgb-23-78,https://pubmed.ncbi.nlm.nih.gov/38023809/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDAR,ENSG00000135960,Unsafe,34916592,Elevated EDAR signalling promotes mammary gland tumourigenesis with squamous metaplasia.,2022,10.1038/s41388-021-01902-6,https://pubmed.ncbi.nlm.nih.gov/34916592/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDDM3A,ENSG00000181562,Unsafe,35039478,EDDM3A drives gastric cancer progression by promoting HIF-1α-dependent aerobic glycolysis.,2022,10.1038/s41389-022-00379-6,https://pubmed.ncbi.nlm.nih.gov/35039478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDDM3A,ENSG00000181562,Unsafe,32391105,Epididymal protein 3A is upregulated and promotes cell proliferation in non-small cell lung cancer.,2020,10.3892/ol.2020.11517,https://pubmed.ncbi.nlm.nih.gov/32391105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDDM3A,ENSG00000181562,Unsafe,26959877,The CHRM3 gene is implicated in abnormal thalamo-orbital frontal cortex functional connectivity in first-episode treatment-naive patients with schizophrenia.,2016,10.1017/s0033291716000167,https://pubmed.ncbi.nlm.nih.gov/26959877/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EDDM3A,ENSG00000181562,Unsafe,26662397,Copy number variations in spermatogenic failure patients with chromosomal abnormalities and unexplained azoospermia.,2015,10.4238/2015.december.7.17,https://pubmed.ncbi.nlm.nih.gov/26662397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB10,ENSG00000185055,Unsafe,41055978,EFCAB10 anchors AK8 to the radial spoke for proper ciliary motility.,2025,10.1073/pnas.2510243122,https://pubmed.ncbi.nlm.nih.gov/41055978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB11,ENSG00000140025,Unsafe,42896796,Exploratory chromosome 14-focused transcriptomic profiling of PSEN1-associated familial Alzheimer's disease across brain regions.,2026,10.1016/j.bbapap.2026.141192,https://pubmed.ncbi.nlm.nih.gov/42896796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB11,ENSG00000140025,Unsafe,41900357,Construction of a DNA Methylation Map of Argali Hybrid Sheep During Mo Infection.,2026,10.3390/microorganisms14030597,https://pubmed.ncbi.nlm.nih.gov/41900357/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB11,ENSG00000140025,Unsafe,39647360,Genome-wide association study of myofiber type composition traits in a yellow-feather broiler population.,2025,10.1016/j.psj.2024.104634,https://pubmed.ncbi.nlm.nih.gov/39647360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB11,ENSG00000140025,Unsafe,37953885,An interpretable Alzheimer's disease oligogenic risk score informed by neuroimaging biomarkers improves risk prediction and stratification.,2023,10.3389/fnagi.2023.1281748,https://pubmed.ncbi.nlm.nih.gov/37953885/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB11,ENSG00000140025,Unsafe,27470294,Characterization of circular RNAs landscape in multiple system atrophy brain.,2016,10.1111/jnc.13752,https://pubmed.ncbi.nlm.nih.gov/27470294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB11,ENSG00000140025,Unsafe,22503546,Follow-up association study of linkage regions reveals multiple candidate genes for carotid plaque in Dominicans.,2012,10.1016/j.atherosclerosis.2012.03.025,https://pubmed.ncbi.nlm.nih.gov/22503546/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB11,ENSG00000140025,Unsafe,24482440,22q11.2 deletion carriers and schizophrenia-associated novel variants.,2014,10.1192/bjp.bp.113.138420,https://pubmed.ncbi.nlm.nih.gov/24482440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB11,ENSG00000140025,Unsafe,26192016,Novel candidate genes for impaired nephron development in a rat model with inherited nephron deficit and albuminuria.,2015,10.1111/1440-1681.12462,https://pubmed.ncbi.nlm.nih.gov/26192016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB11,ENSG00000140025,Unsafe,16573525,High-resolution physical mapping and construction of a porcine contig spanning the intramuscular fat content QTL.,2006,10.1111/j.1365-2052.2005.01397.x,https://pubmed.ncbi.nlm.nih.gov/16573525/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB12,ENSG00000172771,Unsafe,38649688,Biallelic variants identified in 36 Pakistani families and trios with autism spectrum disorder.,2024,10.1038/s41598-024-57942-x,https://pubmed.ncbi.nlm.nih.gov/38649688/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB13,ENSG00000178852,Unsafe,40972679,EFCAB13 is a Novel Age-Dependent Promotor of SOCE in Blood Platelets and Megakaryoblastic MEG-01 Cells.,2026,10.1055/a-2689-7785,https://pubmed.ncbi.nlm.nih.gov/40972679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB13,ENSG00000178852,Unsafe,42094695,Genome-wide association study of myopia progression in Chinese adolescents and application of polygenic risk score prediction.,2026,10.3389/fchem.2026.1778732,https://pubmed.ncbi.nlm.nih.gov/42094695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB13,ENSG00000178852,Unsafe,42129325,S-PrediXcan predicted gene expression in human placenta is associated with childhood-onset asthma risk.,2026,10.1038/s41598-026-51718-1,https://pubmed.ncbi.nlm.nih.gov/42129325/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB13,ENSG00000178852,Unsafe,36405756,Genetic risk variants for multiple sclerosis are linked to differences in alternative pre-mRNA splicing.,2022,10.3389/fimmu.2022.931831,https://pubmed.ncbi.nlm.nih.gov/36405756/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB13,ENSG00000178852,Unsafe,36656640,Effect of mechanical unloading on genome-wide DNA methylation profile of the failing human heart.,2023,10.1172/jci.insight.161788,https://pubmed.ncbi.nlm.nih.gov/36656640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB13,ENSG00000178852,Unsafe,35047017,Contribution of Rare and Low-Frequency Variants to Multiple Sclerosis Susceptibility in the Italian Continental Population.,2021,10.3389/fgene.2021.800262,https://pubmed.ncbi.nlm.nih.gov/35047017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB13,ENSG00000178852,Unsafe,31960101,Associations between catechol-O-methyltransferase (COMT) genotypes at rs4818 and rs4680 and gene expression in human dorsolateral prefrontal cortex.,2020,10.1007/s00221-020-05730-0,https://pubmed.ncbi.nlm.nih.gov/31960101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB13,ENSG00000178852,Unsafe,35252377,"PSRC1 May Affect Coronary Artery Disease Risk by Altering CELSR2, PSRC1, and SORT1 Gene Expression and Circulating Granulin and Apolipoprotein B Protein Levels.",2022,10.3389/fcvm.2022.763015,https://pubmed.ncbi.nlm.nih.gov/35252377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB13,ENSG00000178852,Unsafe,32376501,Proteomic analysis detects deregulated reverse cholesterol transport in human subjects with ST-segment elevation myocardial infarction.,2020,10.1016/j.jprot.2020.103796,https://pubmed.ncbi.nlm.nih.gov/32376501/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB13,ENSG00000178852,Unsafe,29434467,Genomic Analysis Using Regularized Regression in High-Grade Serous Ovarian Cancer.,2018,10.1177/1176935118755341,https://pubmed.ncbi.nlm.nih.gov/29434467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB13,ENSG00000178852,Unsafe,25335771,Fine-mapping the 2q37 and 17q11.2-q22 loci for novel genes and sequence variants associated with a genetic predisposition to prostate cancer.,2015,10.1002/ijc.29276,https://pubmed.ncbi.nlm.nih.gov/25335771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB2,ENSG00000203666,Unsafe,40527793,Identification of novel causally related genes in adenomyosis: An integrated summary data-based Mendelian randomization study and bioinformatics analysis.,2025,10.1097/md.0000000000042768,https://pubmed.ncbi.nlm.nih.gov/40527793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB2,ENSG00000203666,Unsafe,30933994,EFCAB2 is a novel calcium-binding protein in mouse testis and sperm.,2019,10.1371/journal.pone.0214687,https://pubmed.ncbi.nlm.nih.gov/30933994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB2,ENSG00000203666,Unsafe,34334530,Identification of key carcinogenic genes in Wilms' tumor.,2021,10.1266/ggs.21-00015,https://pubmed.ncbi.nlm.nih.gov/34334530/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB2,ENSG00000203666,Unsafe,29428937,High-Throughput Data of Circular RNA Profiles in Human Temporal Cortex Tissue Reveals Novel Insights into Temporal Lobe Epilepsy.,2018,10.1159/000487161,https://pubmed.ncbi.nlm.nih.gov/29428937/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB2,ENSG00000203666,Unsafe,28938569,Evaluation of autoantibody signatures in meningioma patients using human proteome arrays.,2017,10.18632/oncotarget.16997,https://pubmed.ncbi.nlm.nih.gov/28938569/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB2,ENSG00000203666,Unsafe,30259364,Emerging Role of Circular RNAs as Potential Biomarkers for the Diagnosis of Human Diseases.,2018,10.1007/978-981-13-1426-1_12,https://pubmed.ncbi.nlm.nih.gov/30259364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB2,ENSG00000203666,Unsafe,29636822,Maternal interchromosomal insertional translocation leading to 1q43-q44 deletion and duplication in two siblings.,2018,10.1186/s13039-018-0371-7,https://pubmed.ncbi.nlm.nih.gov/29636822/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB2,ENSG00000203666,Unsafe,29459627,Understanding the functional role of genistein in the bone differentiation in mouse osteoblastic cell line MC3T3-E1 by RNA-seq analysis.,2018,10.1038/s41598-018-21601-9,https://pubmed.ncbi.nlm.nih.gov/29459627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB2,ENSG00000203666,Unsafe,30529582,Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.,2019,10.1053/j.gastro.2018.11.066,https://pubmed.ncbi.nlm.nih.gov/30529582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB2,ENSG00000203666,Unsafe,23263656,Identification of gender-specific candidate genes that influence bone microarchitecture in chromosome 1.,2013,10.1007/s00223-012-9687-1,https://pubmed.ncbi.nlm.nih.gov/23263656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB2,ENSG00000203666,Unsafe,20382278,"Four patients with speech delay, seizures and variable corpus callosum thickness sharing a 0.440 Mb deletion in region 1q44 containing the HNRPU gene.",2010,10.1016/j.ejmg.2010.04.001,https://pubmed.ncbi.nlm.nih.gov/20382278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB2,ENSG00000203666,Unsafe,32683206,Genetic association of gemcitabine/carboplatin-induced leukopenia and neutropenia in non-small cell lung cancer patients using whole-exome sequencing.,2020,10.1016/j.lungcan.2020.07.005,https://pubmed.ncbi.nlm.nih.gov/32683206/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB5,ENSG00000176927,Unsafe,40931011,Proximity labeling of axonemal protein CFAP91 identifies EFCAB5 that regulates sperm motility.,2025,10.1038/s41467-025-63705-7,https://pubmed.ncbi.nlm.nih.gov/40931011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB5,ENSG00000176927,Unsafe,42611531,Exploring the shared genetic architecture between post-traumatic stress disorder (PTSD) and obstructive sleep apnea (OSA).,2026,10.1080/20008066.2026.2709174,https://pubmed.ncbi.nlm.nih.gov/42611531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB5,ENSG00000176927,Unsafe,39823331,Genome-wide and phenome-wide studies provided insights into brain glymphatic system function and its clinical associations.,2025,10.1126/sciadv.adr4606,https://pubmed.ncbi.nlm.nih.gov/39823331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB5,ENSG00000176927,Unsafe,39987414,Clinical implications and molecular mechanism of long noncoding RNA LINC00518 and protein-coding genes in skin cutaneous melanoma by genome‑wide investigation.,2025,10.1007/s00403-025-03961-1,https://pubmed.ncbi.nlm.nih.gov/39987414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB5,ENSG00000176927,Unsafe,38967597,Whole-exome sequencing reveals novel cancer genes and actionable targets in biliary tract cancers in primary sclerosing cholangitis.,2024,10.1097/hc9.0000000000000461,https://pubmed.ncbi.nlm.nih.gov/38967597/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB5,ENSG00000176927,Unsafe,35049806,Gene-Set Enrichment Analysis for Identifying Genes and Biological Activities Associated with Growth Traits in Dromedaries.,2022,10.3390/ani12020184,https://pubmed.ncbi.nlm.nih.gov/35049806/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB5,ENSG00000176927,Unsafe,28516910,Genetic architecture of epigenetic and neuronal ageing rates in human brain regions.,2017,10.1038/ncomms15353,https://pubmed.ncbi.nlm.nih.gov/28516910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB6,ENSG00000186976,Unsafe,40643461,CPF Induces GC2&lt;i&gt;&lt;sub&gt;spd&lt;/sub&gt;&lt;/i&gt; Cell Injury via ROS/AKT/Efcab6 Pathway.,2025,10.3390/cells14130940,https://pubmed.ncbi.nlm.nih.gov/40643461/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB6,ENSG00000186976,Unsafe,40943102,Genome-Wide Association Study of Osteoporosis Risk in Korean Pre-Menopausal Women: The Korean Genome and Epidemiology Study.,2025,10.3390/ijms26178177,https://pubmed.ncbi.nlm.nih.gov/40943102/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB6,ENSG00000186976,Unsafe,42612345,Mineral-driven molecular signatures of energy metabolism underpin sperm motility in buffalo.,2026,10.1016/j.anireprosci.2026.108307,https://pubmed.ncbi.nlm.nih.gov/42612345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB6,ENSG00000186976,Unsafe,32616903,The transcriptional signature associated with human motile cilia.,2020,10.1038/s41598-020-66453-4,https://pubmed.ncbi.nlm.nih.gov/32616903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB6,ENSG00000186976,Unsafe,36008755,Exploring Lead loci shared between schizophrenia and Cardiometabolic traits.,2022,10.1186/s12864-022-08766-4,https://pubmed.ncbi.nlm.nih.gov/36008755/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB6,ENSG00000186976,Unsafe,29599708,Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control.,2018,10.3389/fnmol.2018.00068,https://pubmed.ncbi.nlm.nih.gov/29599708/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB6,ENSG00000186976,Unsafe,34497285,Pituitary hormones are specifically expressed in trigeminal sensory neurons and contribute to pain responses in the trigeminal system.,2021,10.1038/s41598-021-97084-y,https://pubmed.ncbi.nlm.nih.gov/34497285/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB6,ENSG00000186976,Unsafe,31639337,Effector gene expression underlying neuron subtype-specific traits in the Motor Ganglion of Ciona.,2020,10.1016/j.ydbio.2019.10.012,https://pubmed.ncbi.nlm.nih.gov/31639337/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB6,ENSG00000186976,Unsafe,31124294,Cytogenetic and molecular diagnosis of Fanconi anemia revealed two hidden phenotypes: Disorder of sex development and cerebro-oculo-facio-skeletal syndrome.,2019,10.1002/mgg3.694,https://pubmed.ncbi.nlm.nih.gov/31124294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB6,ENSG00000186976,Unsafe,22749035,Identification of a HMGA2-EFCAB6 gene rearrangement following next-generation sequencing in a patient with a t(12;22)(q14.3;q13.2) and JAK2V617F-positive myeloproliferative neoplasm.,2012,10.1016/j.cancergen.2012.03.006,https://pubmed.ncbi.nlm.nih.gov/22749035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB6,ENSG00000186976,Unsafe,25646840,Fetal-adult cardiac transcriptome analysis in rats with contrasting left ventricular mass reveals new candidates for cardiac hypertrophy.,2015,10.1371/journal.pone.0116807,https://pubmed.ncbi.nlm.nih.gov/25646840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB6,ENSG00000186976,Unsafe,30714281,"Evaluation of the four breeds in synthetic line of Jiaxing Black Pigs and Berkshire for meat quality traits, carcass characteristics, and flavor substances.",2019,10.1111/asj.13169,https://pubmed.ncbi.nlm.nih.gov/30714281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB6,ENSG00000186976,Unsafe,29764119,Founder Mutations for Early Onset Melanoma as Revealed by Whole Exome Sequencing Suggests That This is Not Associated with the Increasing Incidence of Melanoma in Poland.,2019,10.4143/crt.2018.157,https://pubmed.ncbi.nlm.nih.gov/29764119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB6,ENSG00000186976,Unsafe,12612053,"DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex.",2003,,https://pubmed.ncbi.nlm.nih.gov/12612053/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB6,ENSG00000186976,Unsafe,11258795,Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping.,2001,10.1093/dnares/8.1.1,https://pubmed.ncbi.nlm.nih.gov/11258795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EFCAB6,ENSG00000186976,Unsafe,18563496,Laparoscopic sleeve gastrectomy with duodeno-jejunal bypass: a new surgical procedure for weight control. Feasibility and safety study in a porcine model.,2008,10.1007/s11695-008-9602-z,https://pubmed.ncbi.nlm.nih.gov/18563496/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,42250080,EGFL6 predicts unfavorable prognosis and serves as a potential indicator in esophageal carcinoma.,2026,10.1007/s12672-026-05372-8,https://pubmed.ncbi.nlm.nih.gov/42250080/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,42512880,Differential Gene Expression in Synovium Between Male and Female Knee Osteoarthritis.,2026,10.3390/medicina62071338,https://pubmed.ncbi.nlm.nih.gov/42512880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,42283414,Yin Yang 1 Specifically Supports the Development of Olig2 Positive Cerebellar Astrocytes.,2026,10.1002/glia.70185,https://pubmed.ncbi.nlm.nih.gov/42283414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,41151154,"EGFL6 is a novel HER3 ligand, inducing HER3/integrin heterodimers to induce pERK centrosomal deposition and therapeutic resistance.",2025,10.1016/j.neo.2025.101246,https://pubmed.ncbi.nlm.nih.gov/41151154/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,40595086,Expression and prognostic value of EGF-like domain multiple 6 in uterine corpus endometrial carcinoma and its correlation with immune cell infiltration.,2025,10.1038/s41598-025-07379-7,https://pubmed.ncbi.nlm.nih.gov/40595086/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,40468928,EGFL6 Promotes Angiogenesis and Odontogenesis in Pulp Regeneration &lt;i&gt;via&lt;/i&gt; MAPK Signaling Pathways.,2026,10.2174/011574888x362657250528171158,https://pubmed.ncbi.nlm.nih.gov/40468928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,41555699,"Transcriptional Activation of EGFL6 by E2F8 Promotes Proliferation, Migration, and Invasion in Endometrial Carcinoma Cell.",2026,10.1111/boc.70050,https://pubmed.ncbi.nlm.nih.gov/41555699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,39312740,Egfl6 promotes ovarian cancer progression by enhancing the immunosuppressive functions of tumor-associated myeloid cells.,2024,10.1172/jci175147,https://pubmed.ncbi.nlm.nih.gov/39312740/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,39187367,Cytoplasmic Expression of the EGFL6 Protein Is an Independent Prognostic Factor for Shortened Patient Survival in Human Hepatocellular Carcinoma.,2024,10.21873/invivo.13715,https://pubmed.ncbi.nlm.nih.gov/39187367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,36507067,Progress of EGFL6 in angiogenesis and tumor development.,2022,,https://pubmed.ncbi.nlm.nih.gov/36507067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,41821534,Comparative Analysis of Meat Quality and Muscle Transcriptome between Landrace and Jeju Native Pig.,2025,10.5851/kosfa.2025.e20,https://pubmed.ncbi.nlm.nih.gov/41821534/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,42832172,Remodeling of Oncogene-Related Molecular Networks Following Bariatric Surgery: a Multi-Omics Study.,2026,10.1007/s11695-026-08959-w,https://pubmed.ncbi.nlm.nih.gov/42832172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,41149482,The Emerging Role of CKAP4 in GI Cancer: From Molecular Pathways to Clinical Applications.,2025,10.3390/curroncol32100561,https://pubmed.ncbi.nlm.nih.gov/41149482/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,40868176,Identification of Candidate Genes for Endometriosis in a Three-Generation Family with Multiple Affected Members Using Whole-Exome Sequencing.,2025,10.3390/biomedicines13081922,https://pubmed.ncbi.nlm.nih.gov/40868176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,42220495,The enigmatic role of tumor dormancy cells in gynecologic cancers.,2026,10.3389/fimmu.2026.1836770,https://pubmed.ncbi.nlm.nih.gov/42220495/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,38368816,EGFL6 promotes endometrial cancer cell migration and proliferation.,2024,10.1016/j.ygyno.2024.02.016,https://pubmed.ncbi.nlm.nih.gov/38368816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,40374694,Effects of metformin on transcriptomic and metabolomic profiles in breast cancer survivors enrolled in the randomized placebo-controlled MetBreCS trial.,2025,10.1038/s41598-025-01705-9,https://pubmed.ncbi.nlm.nih.gov/40374694/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,41073785,Single-cell multi-omic and spatial profiling of esophageal squamous cell carcinoma reveals the immunosuppressive role of GPR116&lt;sup&gt;+&lt;/sup&gt; pericytes in cancer metastasis.,2025,10.1038/s41588-025-02341-9,https://pubmed.ncbi.nlm.nih.gov/41073785/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,40424883,RNA sequencing and genome-wide association analysis reveal key genes responsible for different feather colors in Youjiang goose.,2025,10.1016/j.psj.2025.105305,https://pubmed.ncbi.nlm.nih.gov/40424883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,41080910,Transcriptomic Profiling of Dental Tissue-Derived Mesenchymal Stem Cells.,2025,10.1155/sci/4789882,https://pubmed.ncbi.nlm.nih.gov/41080910/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,42301653,CRISPR/Cas in gynecologic cancers: A review of experimental and therapeutic applications.,2026,10.4103/ijc.ijc_14_25,https://pubmed.ncbi.nlm.nih.gov/42301653/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,39503984,Prognosis and immunotherapy significances of a cancer-associated fibroblasts-related gene signature in bladder urothelial carcinoma.,2024,10.1007/s12672-024-01505-z,https://pubmed.ncbi.nlm.nih.gov/39503984/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,36804621,Generation and characterization of humanized affinity-matured EGFL6 antibodies for ovarian cancer therapy.,2023,10.1016/j.ygyno.2023.02.004,https://pubmed.ncbi.nlm.nih.gov/36804621/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,35457174,Transcriptome Analyses of Adipose Tissue Samples Identify EGFL6 as a Candidate Gene Involved in Obesity-Related Adipose Tissue Dysfunction in Children.,2022,10.3390/ijms23084349,https://pubmed.ncbi.nlm.nih.gov/35457174/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,33726836,EGFL6 promotes colorectal cancer cell growth and mobility and the anti-cancer property of anti-EGFL6 antibody.,2021,10.1186/s13578-021-00561-0,https://pubmed.ncbi.nlm.nih.gov/33726836/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,33760211,Upregulation of miR‑126 inhibits podocyte injury in sepsis via EGFL6/DKC1 signaling pathway.,2021,10.3892/mmr.2021.12012,https://pubmed.ncbi.nlm.nih.gov/33760211/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,30455428,EGFL6 promotes breast cancer by simultaneously enhancing cancer cell metastasis and stimulating tumor angiogenesis.,2019,10.1038/s41388-018-0565-9,https://pubmed.ncbi.nlm.nih.gov/30455428/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,29212026,Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis.,2017,10.1016/j.celrep.2017.11.020,https://pubmed.ncbi.nlm.nih.gov/29212026/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,34830910,Prognostic Matrisomal Gene Panel and Its Association with Immune Cell Infiltration in Head and Neck Carcinomas.,2021,10.3390/cancers13225761,https://pubmed.ncbi.nlm.nih.gov/34830910/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,36816947,Spatially resolved transcriptomics revealed local invasion-related genes in colorectal cancer.,2023,10.3389/fonc.2023.1089090,https://pubmed.ncbi.nlm.nih.gov/36816947/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,31533811,Screening circulating proteins to identify biomarkers of fetal macrosomia.,2019,10.1186/s13104-019-4625-1,https://pubmed.ncbi.nlm.nih.gov/31533811/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,34660776,Identification of Specific Cell Subpopulations and Marker Genes in Ovarian Cancer Using Single-Cell RNA Sequencing.,2021,10.1155/2021/1005793,https://pubmed.ncbi.nlm.nih.gov/34660776/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGFL6,ENSG00000198759,Unsafe,31196165,Genome-wide enriched pathway analysis of acute post-radiotherapy pain in breast cancer patients: a prospective cohort study.,2019,10.1186/s40246-019-0212-8,https://pubmed.ncbi.nlm.nih.gov/31196165/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,40815265,egr1 and egr4 regulate zebrafish renal regeneration by promoting foxm1 expression.,2026,10.1093/jmcb/mjaf026,https://pubmed.ncbi.nlm.nih.gov/40815265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,41439205,Propofol induces neuronal damage in developing mice by inhibiting EGR4 transcription and regulating NPAS4 expression.,2025,10.1093/toxres/tfaf183,https://pubmed.ncbi.nlm.nih.gov/41439205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,40218405,Early Growth Response Factor 4 (EGR4) Expression in Gut Tissues and Regional Lymph Nodes of Cattle with Different Types of Paratuberculosis-Associated Lesions: Potential Role of EGR4 in Resilience to Paratuberculosis.,2025,10.3390/ani15071012,https://pubmed.ncbi.nlm.nih.gov/40218405/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,41760705,The Caspase-1-EGR4 axis regulates macrophage repolarization in acute myeloid leukemia cells.,2026,10.1038/s41598-026-41381-x,https://pubmed.ncbi.nlm.nih.gov/41760705/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,41203604,EGR4 transcriptionally upregulates GDF15 to promote gastric cancer metastasis.,2025,10.1038/s41419-025-08095-w,https://pubmed.ncbi.nlm.nih.gov/41203604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,41579373,Decoding the heterogeneity of human undifferentiated spermatogonia reveals RAS-dependent regulation of stem cell fate.,2026,10.1016/j.celrep.2025.116868,https://pubmed.ncbi.nlm.nih.gov/41579373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,41486724,EGR Proteins Mediate Interferon-Independent Anti-HSV-1 Responses Through Viral and Host Targets.,2026,10.1002/advs.202515546,https://pubmed.ncbi.nlm.nih.gov/41486724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,39367986,NFYA-mediated promotion of castration-resistant prostate cancer progression through EGR4 regulation.,2024,10.1007/s12672-024-01392-4,https://pubmed.ncbi.nlm.nih.gov/39367986/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,42164519,Redox-modulated ERK dynamics support wound-dependent tissue formation during early planarian regeneration.,2026,10.1016/j.isci.2026.115640,https://pubmed.ncbi.nlm.nih.gov/42164519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,40444475,Multifaceted regulatory mechanisms of the EGR family in tumours and prospects for therapeutic applications (Review).,2025,10.3892/ijmm.2025.5554,https://pubmed.ncbi.nlm.nih.gov/40444475/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,42674312,Cocaine-induced interindividual variability in female rats: From behavior to gene expression.,2026,10.1016/j.neuropharm.2026.111160,https://pubmed.ncbi.nlm.nih.gov/42674312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,39985763,Age-Dependent Clonal Expansion of Non-Sperm-Forming Spermatogonial Stem Cells in Mouse Testes.,2025,10.1111/acel.70019,https://pubmed.ncbi.nlm.nih.gov/39985763/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,38459370,Identification of EGR4 as a prospective target for inhibiting tumor cell proliferation and a novel biomarker in colorectal cancer.,2024,10.1038/s41417-024-00743-1,https://pubmed.ncbi.nlm.nih.gov/38459370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,38166990,Small-molecule agonist AdipoRon alleviates diabetic retinopathy through the AdipoR1/AMPK/EGR4 pathway.,2024,10.1186/s12967-023-04783-3,https://pubmed.ncbi.nlm.nih.gov/38166990/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,39518903,Altered Expression of Neuroplasticity-Related Genes in Alcohol Addiction and Treatment.,2024,10.3390/ijms252111349,https://pubmed.ncbi.nlm.nih.gov/39518903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,39898299,Hippocampal gene expression changes associated with sequential behavioral training in a temporal lobe epilepsy rat model.,2025,10.1016/j.ebr.2024.100735,https://pubmed.ncbi.nlm.nih.gov/39898299/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,38691090,Noninvasive Light Flicker Stimulation Promotes Optic Nerve Regeneration by Activating Microglia and Enhancing Neural Plasticity in Zebrafish.,2024,10.1167/iovs.65.5.3,https://pubmed.ncbi.nlm.nih.gov/38691090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,40222268,Gut microbiome depletion modulates cocaine-induced behavioral and transcriptional responses in female mice.,2025,10.1016/j.jneuroim.2025.578609,https://pubmed.ncbi.nlm.nih.gov/40222268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,35326716,Regulation of a Novel Splice Variant of Early Growth Response 4 (EGR4-S) by HER+ Signalling and HSF1 in Breast Cancer.,2022,10.3390/cancers14061567,https://pubmed.ncbi.nlm.nih.gov/35326716/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,40320842,Analysis and Identification of Therapeutic Targets for Neuronal Regeneration After Ischemic Stroke.,2025,10.1002/brb3.70377,https://pubmed.ncbi.nlm.nih.gov/40320842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,42843034,Environmentally relevant lanthanum chloride exposure induces neurotoxicity in zebrafish through serotonergic disruption and synaptic dysfunction.,2026,10.1016/j.ecoenv.2026.120901,https://pubmed.ncbi.nlm.nih.gov/42843034/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,38586100,Screening of potential biomarkers in propofol-induced neurotoxicity via bioinformatics prediction and experimental verification.,2024,10.62347/mtay7931,https://pubmed.ncbi.nlm.nih.gov/38586100/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,32212315,Suppression of Ca2+ signals by EGR4 controls Th1 differentiation and anti-cancer immunity in vivo.,2020,10.15252/embr.201948904,https://pubmed.ncbi.nlm.nih.gov/32212315/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,36029576,"Systems assessment of statins hazard: Integrating in silico prediction, developmental toxicity profile and transcriptomics in zebrafish.",2022,10.1016/j.ecoenv.2022.113981,https://pubmed.ncbi.nlm.nih.gov/36029576/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,37821814,Summary-data based Mendelian randomization identifies gene expression regulatory polymorphisms associated with bovine paratuberculosis by modulation of the nuclear factor Kappa β (NF-κß)-mediated inflammatory response.,2023,10.1186/s12864-023-09710-w,https://pubmed.ncbi.nlm.nih.gov/37821814/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,36046377,The Landscape of Early Growth Response Family Members 1-4 in Hepatocellular Carcinoma: Their Biological Roles and Diagnostic Utility.,2022,10.1155/2022/3144742,https://pubmed.ncbi.nlm.nih.gov/36046377/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,33614706,A Risk Prediction Model for Breast Cancer Based on Immune Genes Related to Early Growth Response Proteins Family.,2020,10.3389/fmolb.2020.616547,https://pubmed.ncbi.nlm.nih.gov/33614706/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,36870174,The metabolites could not be ignored: A comparative study of the metabolite norfluoxetine with its parent fluoxetine on zebrafish (Danio rerio).,2023,10.1016/j.aquatox.2023.106467,https://pubmed.ncbi.nlm.nih.gov/36870174/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,37910253,Neuronal membrane proteasome-derived peptides modulate NMDAR-dependent neuronal signaling to promote changes in gene expression.,2024,10.1091/mbc.e23-06-0218,https://pubmed.ncbi.nlm.nih.gov/37910253/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,30556283,A positive feedback loop between ZNF205-AS1 and EGR4 promotes non-small cell lung cancer growth.,2019,10.1111/jcmm.14056,https://pubmed.ncbi.nlm.nih.gov/30556283/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,34622232,Single-cell RNA-seq unravels alterations of the human spermatogonial stem cell compartment in patients with impaired spermatogenesis.,2021,10.1016/j.xcrm.2021.100395,https://pubmed.ncbi.nlm.nih.gov/34622232/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,39027680,Fe3O4 coated stent prevent artery neointimal hyperplasia by inhibiting vascular smooth muscle cell proliferation.,2024,10.1016/j.mtbio.2024.101133,https://pubmed.ncbi.nlm.nih.gov/39027680/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EGR4,ENSG00000135625,Unsafe,35746681,EGR1 Upregulation during Encephalitic Viral Infections Contributes to Inflammation and Cell Death.,2022,10.3390/v14061210,https://pubmed.ncbi.nlm.nih.gov/35746681/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,39551708,EP300-interacting inhibitor of differentiation 3 is required for spermatogenesis in mice.,2025,10.1111/andr.13800,https://pubmed.ncbi.nlm.nih.gov/39551708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,38433441,Increased oxidized low-density lipoprotein in mice exposed to a high-fat diet impaired spermatogenesis by inhibiting testosterone synthesis via the Klk1bs/Eid3 pathway.,2024,10.1002/ctm2.1603,https://pubmed.ncbi.nlm.nih.gov/38433441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,38216090,EID3 inhibits the osteogenic differentiation of periodontal ligament stem cells and mediates the signal transduction of TAZ-EID3-AKT/MTOR/ERK.,2024,10.1016/j.bbamcr.2024.119662,https://pubmed.ncbi.nlm.nih.gov/38216090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,36344477,EID3 Promotes Glioma Cell Proliferation and Survival by Inactivating AMPKα1.,2022,10.3340/jkns.2021.0298,https://pubmed.ncbi.nlm.nih.gov/36344477/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,39489219,Screening of Cancer-Specific Biomarkers for Hepatitis B-Related Hepatocellular Carcinoma Based on a Proteome Microarray.,2024,10.1016/j.mcpro.2024.100872,https://pubmed.ncbi.nlm.nih.gov/39489219/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,40059261,Exosomal miR-92a-3p modulates M2 macrophage polarization in colorectal cancer: implications for tumor migration and angiogenesis.,2025,10.1007/s12032-025-02635-2,https://pubmed.ncbi.nlm.nih.gov/40059261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,36964252,Mesenchymal stem cell-derived extracellular vesicles subvert Th17 cells by destabilizing RORγt through posttranslational modification.,2023,10.1038/s12276-023-00949-7,https://pubmed.ncbi.nlm.nih.gov/36964252/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,36071872,EID3 Promotes Cancer Stem Cell-Like Phenotypes in Osteosarcoma through the Activation of PI3K-AKT Signaling Pathway.,2022,10.1155/2022/5941562,https://pubmed.ncbi.nlm.nih.gov/36071872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,37790842,Dasatinib regulates the proliferation and osteogenic differentiation of PDLSCs through Erk and EID3 signals.,2023,10.7150/ijms.87089,https://pubmed.ncbi.nlm.nih.gov/37790842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,39147981,DNA Methylation Patterns Associated with Tinnitus in Young Adults-A Pilot Study.,2024,10.1007/s10162-024-00961-2,https://pubmed.ncbi.nlm.nih.gov/39147981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,32509069,Overexpression of EP300-interacting inhibitor of differentiation 3 predicts poor prognosis in patients with glioblastoma multiforme.,2020,,https://pubmed.ncbi.nlm.nih.gov/32509069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,37086071,Uncover DNA damage and repair-related gene signature and risk score model for glioma.,2023,10.1080/07853890.2023.2200033,https://pubmed.ncbi.nlm.nih.gov/37086071/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,36153608,Radiochemotherapy-induced DNA repair promotes the biogenesis of gastric cancer stem cells.,2022,10.1186/s13287-022-03165-8,https://pubmed.ncbi.nlm.nih.gov/36153608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,29290942,Identification of novel serum autoantibodies against EID3 in non-functional pancreatic neuroendocrine tumors.,2017,10.18632/oncotarget.22175,https://pubmed.ncbi.nlm.nih.gov/29290942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,28074931,EID3 directly associates with DNMT3A during transdifferentiation of human umbilical cord mesenchymal stem cells to NPC-like cells.,2017,10.1038/srep40463,https://pubmed.ncbi.nlm.nih.gov/28074931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,36514984,A fast-growing dengue virus mutant reveals a dual role of STING in response to infection.,2022,10.1098/rsob.220227,https://pubmed.ncbi.nlm.nih.gov/36514984/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,30114644,Upregulation of EID3 sensitizes breast cancer cells to ionizing radiation-induced cellular senescence.,2018,10.1016/j.biopha.2018.08.022,https://pubmed.ncbi.nlm.nih.gov/30114644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,33668931,"Based on a Self-Feeder Layer, a Novel 3D Culture Model of Human ADSCs Facilitates Trans-Differentiation of the Spheroid Cells into Neural Progenitor-Like Cells Using siEID3 with a Laminin/Poly-d-lysine Matrix.",2021,10.3390/cells10030493,https://pubmed.ncbi.nlm.nih.gov/33668931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,33204664,Development and Verification of the Hypoxia-Related and Immune-Associated Prognosis Signature for Hepatocellular Carcinoma.,2020,10.2147/jhc.s272109,https://pubmed.ncbi.nlm.nih.gov/33204664/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID2B,ENSG00000176401,Unsafe,34821436,A novel immunodiagnosis panel for hepatocellular carcinoma based on bioinformatics and the autoantibody-antigen system.,2022,10.1111/cas.15217,https://pubmed.ncbi.nlm.nih.gov/34821436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,39551708,EP300-interacting inhibitor of differentiation 3 is required for spermatogenesis in mice.,2025,10.1111/andr.13800,https://pubmed.ncbi.nlm.nih.gov/39551708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,38433441,Increased oxidized low-density lipoprotein in mice exposed to a high-fat diet impaired spermatogenesis by inhibiting testosterone synthesis via the Klk1bs/Eid3 pathway.,2024,10.1002/ctm2.1603,https://pubmed.ncbi.nlm.nih.gov/38433441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,38216090,EID3 inhibits the osteogenic differentiation of periodontal ligament stem cells and mediates the signal transduction of TAZ-EID3-AKT/MTOR/ERK.,2024,10.1016/j.bbamcr.2024.119662,https://pubmed.ncbi.nlm.nih.gov/38216090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,36344477,EID3 Promotes Glioma Cell Proliferation and Survival by Inactivating AMPKα1.,2022,10.3340/jkns.2021.0298,https://pubmed.ncbi.nlm.nih.gov/36344477/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,39489219,Screening of Cancer-Specific Biomarkers for Hepatitis B-Related Hepatocellular Carcinoma Based on a Proteome Microarray.,2024,10.1016/j.mcpro.2024.100872,https://pubmed.ncbi.nlm.nih.gov/39489219/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,36964252,Mesenchymal stem cell-derived extracellular vesicles subvert Th17 cells by destabilizing RORγt through posttranslational modification.,2023,10.1038/s12276-023-00949-7,https://pubmed.ncbi.nlm.nih.gov/36964252/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,36071872,EID3 Promotes Cancer Stem Cell-Like Phenotypes in Osteosarcoma through the Activation of PI3K-AKT Signaling Pathway.,2022,10.1155/2022/5941562,https://pubmed.ncbi.nlm.nih.gov/36071872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,37790842,Dasatinib regulates the proliferation and osteogenic differentiation of PDLSCs through Erk and EID3 signals.,2023,10.7150/ijms.87089,https://pubmed.ncbi.nlm.nih.gov/37790842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,39147981,DNA Methylation Patterns Associated with Tinnitus in Young Adults-A Pilot Study.,2024,10.1007/s10162-024-00961-2,https://pubmed.ncbi.nlm.nih.gov/39147981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,32509069,Overexpression of EP300-interacting inhibitor of differentiation 3 predicts poor prognosis in patients with glioblastoma multiforme.,2020,,https://pubmed.ncbi.nlm.nih.gov/32509069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,37086071,Uncover DNA damage and repair-related gene signature and risk score model for glioma.,2023,10.1080/07853890.2023.2200033,https://pubmed.ncbi.nlm.nih.gov/37086071/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,36153608,Radiochemotherapy-induced DNA repair promotes the biogenesis of gastric cancer stem cells.,2022,10.1186/s13287-022-03165-8,https://pubmed.ncbi.nlm.nih.gov/36153608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,29290942,Identification of novel serum autoantibodies against EID3 in non-functional pancreatic neuroendocrine tumors.,2017,10.18632/oncotarget.22175,https://pubmed.ncbi.nlm.nih.gov/29290942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,28074931,EID3 directly associates with DNMT3A during transdifferentiation of human umbilical cord mesenchymal stem cells to NPC-like cells.,2017,10.1038/srep40463,https://pubmed.ncbi.nlm.nih.gov/28074931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,36514984,A fast-growing dengue virus mutant reveals a dual role of STING in response to infection.,2022,10.1098/rsob.220227,https://pubmed.ncbi.nlm.nih.gov/36514984/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,30114644,Upregulation of EID3 sensitizes breast cancer cells to ionizing radiation-induced cellular senescence.,2018,10.1016/j.biopha.2018.08.022,https://pubmed.ncbi.nlm.nih.gov/30114644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,33668931,"Based on a Self-Feeder Layer, a Novel 3D Culture Model of Human ADSCs Facilitates Trans-Differentiation of the Spheroid Cells into Neural Progenitor-Like Cells Using siEID3 with a Laminin/Poly-d-lysine Matrix.",2021,10.3390/cells10030493,https://pubmed.ncbi.nlm.nih.gov/33668931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,33204664,Development and Verification of the Hypoxia-Related and Immune-Associated Prognosis Signature for Hepatocellular Carcinoma.,2020,10.2147/jhc.s272109,https://pubmed.ncbi.nlm.nih.gov/33204664/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,34821436,A novel immunodiagnosis panel for hepatocellular carcinoma based on bioinformatics and the autoantibody-antigen system.,2022,10.1111/cas.15217,https://pubmed.ncbi.nlm.nih.gov/34821436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,35186021,Clinical and Biological Significance of DNA Methylation-Driven Differentially Expressed Genes in Biochemical Recurrence After Radical Prostatectomy.,2022,10.3389/fgene.2022.727307,https://pubmed.ncbi.nlm.nih.gov/35186021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EID3,ENSG00000255150,Unsafe,15987788,EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation.,2005,10.1093/nar/gki667,https://pubmed.ncbi.nlm.nih.gov/15987788/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,41404795,Eukaryotic translation initiation factor 4F: functional properties and physiological role.,2025,10.1093/nar/gkaf1351,https://pubmed.ncbi.nlm.nih.gov/41404795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,41799498,"Combinational Inhibition of the eIF4F Complex, AKT1, and EZH2 Enhances Anticancer Effects in BRAF&lt;sup&gt;V600E&lt;/sup&gt; Mutant A375 Melanoma Cells.",2026,10.32604/or.2025.071034,https://pubmed.ncbi.nlm.nih.gov/41799498/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,42733661,Altered striatal long-term potentiation in the eIF4E-TG mouse model of autism spectrum disorder.,2026,10.1016/j.isci.2026.117278,https://pubmed.ncbi.nlm.nih.gov/42733661/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,42157944,Surfactant Protein B Precursor Inhibit the Progression of Resectable Non-small Cell Lung Cancer by Suppressing eIF4F-mediated Immune Evasion and Cancer Stemness.,2026,10.7150/ijbs.134006,https://pubmed.ncbi.nlm.nih.gov/42157944/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,41776682,The related EIF4G3 and EIF4G4 initiation factors from Leishmania: dissimilar modes of action during translation revealed by a comparative proteomic approach.,2026,10.1186/s13071-026-07297-1,https://pubmed.ncbi.nlm.nih.gov/41776682/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,42666719,Investigation of the Mechanism of Total Flavonoids From Chuju in Mitigating Cerebral Ischemia-Reperfusion Injury in Rats Using Untargeted Metabolomics.,2026,10.1002/fsn3.72216,https://pubmed.ncbi.nlm.nih.gov/42666719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,42794618,Experimental Confirmation of the Role of the α1-α2 Hairpin PVY VPg in eIF4E Interaction.,2026,10.3390/ijms27188187,https://pubmed.ncbi.nlm.nih.gov/42794618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,42888202,Targeting the eIF4F translation initiation complex disrupts BCR::ABL1 translation and overcomes drug resistance in CML.,2026,10.1038/s41375-026-03157-0,https://pubmed.ncbi.nlm.nih.gov/42888202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,42278621,eIF4E-Dependent Translation Potentially Regulates Apoptosis and BDNF/TrkB Signaling in the Medial Prefrontal Cortex During Morphine-Induced CPP.,2026,10.3390/ijms27115097,https://pubmed.ncbi.nlm.nih.gov/42278621/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,42050705,Translational control of AMPK activity in melanoma.,2026,10.1186/s12964-026-02901-4,https://pubmed.ncbi.nlm.nih.gov/42050705/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,41755641,CELF1 is a non-canonical eIF4E binding protein that promotes translation of epithelial-mesenchymal transition effector mRNAs.,2026,10.1093/nar/gkag123,https://pubmed.ncbi.nlm.nih.gov/41755641/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,42892507,Repurposing Entrectinib and Ibrutinib as MNK/eIF4E pathway modulators in ovarian cancer.,2026,10.1016/j.ejphar.2026.179438,https://pubmed.ncbi.nlm.nih.gov/42892507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,42826912,Mechanistic role of eIF4E in the hallmarks of cancer: A translational control perspective.,2026,10.1016/j.critrevonc.2026.105623,https://pubmed.ncbi.nlm.nih.gov/42826912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,40952561,The many ways to inhibit translation by Sorafenib in liver cancer cells.,2026,10.1007/s11010-025-05391-z,https://pubmed.ncbi.nlm.nih.gov/40952561/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,42794724,"Per- and Polyfluoroalkyl Substances and Papillary Thyroid Carcinoma: An Integrative Study of Bioinformatics, Epidemiological Associations, and In Vitro Responses.",2026,10.3390/ijms27188296,https://pubmed.ncbi.nlm.nih.gov/42794724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,42645582,CERES forms a complex with RH37 and eIF4E.,2026,10.1007/s00299-026-03888-5,https://pubmed.ncbi.nlm.nih.gov/42645582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,41468962,Discovery of a small-molecule inhibitor of eIF4E suppressing tumor proliferation via lipid metabolic reprogramming.,2026,10.1016/j.jare.2025.12.050,https://pubmed.ncbi.nlm.nih.gov/41468962/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,42234179,Circular RNA circTrpc6-induced tau phosphorylation contributes to neuronal injury and cognitive decline via miR-485-5p/eIF4E axis in senescence-accelerated mouse prone 8 mice.,2026,10.1007/s10565-026-10214-y,https://pubmed.ncbi.nlm.nih.gov/42234179/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,42157946,ABHD11-AS1 Suppresses Colorectal Cancer Progression by Disrupting EIF4E-mediated POU2F1 Ubiquitination.,2026,10.7150/ijbs.125799,https://pubmed.ncbi.nlm.nih.gov/42157946/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,41795048,Correction of eIF4E overactivation rescues translatome imbalance and core ASD-like behaviors in valproic acid-induced offspring mice.,2026,10.1038/s41380-026-03517-3,https://pubmed.ncbi.nlm.nih.gov/41795048/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,42352951,N7-Methylguanosine Modification in Colorectal Cancer: Molecular Insights and Clinical Implications.,2026,10.3390/ijms27125228,https://pubmed.ncbi.nlm.nih.gov/42352951/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,41417572,TOPK Inhibition Promotes Anti-Tumor Immunity Via eIF4F Complex Mediated STAT1 Translation in Gastric Cancer.,2026,10.1002/advs.202517380,https://pubmed.ncbi.nlm.nih.gov/41417572/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,42773810,Repurposing the third-generation EGFR inhibitor osimertinib to synergize with paclitaxel and extend survival in anaplastic thyroid cancer.,2026,10.1080/08923973.2026.2735423,https://pubmed.ncbi.nlm.nih.gov/42773810/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,42302788,P5CS represses tumor progression via inhibiting assembly of 48S pre-translation initiation complex.,2026,10.1016/j.devcel.2026.05.011,https://pubmed.ncbi.nlm.nih.gov/42302788/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,40308810,Dual MNK/VEGFR2 Inhibitor JDB153 Enhances Immunotherapeutic Efficiency and Chemosensitivity in Lung Cancer.,2025,10.1002/mco2.70155,https://pubmed.ncbi.nlm.nih.gov/40308810/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,41984598,Therapeutic targeting of the eIF4E cap-binding domain reveals control of lineage fate in prostate cancer.,2026,10.1172/jci199838,https://pubmed.ncbi.nlm.nih.gov/41984598/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,41199267,Lack of phospho-eIF4E worsens experimental colitis by inhibiting Treg suppressive activity.,2025,10.1186/s12950-025-00476-4,https://pubmed.ncbi.nlm.nih.gov/41199267/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,41599754,Cinobufagin as a Potential Intervention Against Liver Cancer-A Comprehensive Review.,2026,10.3390/ph19010158,https://pubmed.ncbi.nlm.nih.gov/41599754/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,40016176,RNA-binding proteins as therapeutic targets in cancer.,2025,10.1080/15476286.2025.2470511,https://pubmed.ncbi.nlm.nih.gov/40016176/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,42294890,Rewriting the cancer proteome: targeting selective translation as a therapeutic frontier.,2026,10.1172/jci207335,https://pubmed.ncbi.nlm.nih.gov/42294890/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,41418357,Mechanistic link between eIF4E phosphorylation and viral pathogenesis: Therapeutic insights from a porcine model.,2026,10.1016/j.vetmic.2025.110818,https://pubmed.ncbi.nlm.nih.gov/41418357/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,41955490,Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2-arm mRNA Platform.,2026,10.1002/advs.75244,https://pubmed.ncbi.nlm.nih.gov/41955490/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EIF4E,ENSG00000151247,Unsafe,42409259,SLFN11 binds DDX1 to counteract human mesenchymal stem/stromal cell senescence through inhibition of mTOR/eIF4E signaling pathway activation.,2026,10.1016/j.lfs.2026.124579,https://pubmed.ncbi.nlm.nih.gov/42409259/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,42556336,"Variants leading to ELAVL2 haploinsufficiency cause a neurodevelopmental disorder with prominent cognitive, behavioral, and neurological features.",2026,10.1016/j.ajhg.2026.07.007,https://pubmed.ncbi.nlm.nih.gov/42556336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,42719988,PIEZO1 Mediates Myoblast Proliferation Under Simulated Microgravity.,2026,10.1111/nyas.70362,https://pubmed.ncbi.nlm.nih.gov/42719988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,41361662,Integrated Bioinformatics Analysis of Differentially Expressed RNA-Binding Proteins in Human Gliomas.,2025,10.1007/s10571-025-01608-3,https://pubmed.ncbi.nlm.nih.gov/41361662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,42010507,KLF2 alleviates sepsis-induced acute kidney injury via the lncRNA GAS6-AS2/GOLPH3 axis.,2026,10.1186/s12882-026-04908-y,https://pubmed.ncbi.nlm.nih.gov/42010507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,42290793,Transcriptomic and differential gene analysis investigating the differences in biological behaviour between subtypes of feline alimentary lymphoma.,2026,10.3389/fvets.2026.1764747,https://pubmed.ncbi.nlm.nih.gov/42290793/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,40000387,"ELAV/Hu RNA-binding protein family: key regulators in neurological disorders, cancer, and other diseases.",2025,10.1080/15476286.2025.2471133,https://pubmed.ncbi.nlm.nih.gov/40000387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,40560724,Reverse engineering neuron-type-specific and type-orthogonal splicing-regulatory networks using diverse cellular transcriptomes.,2025,10.1016/j.celrep.2025.115898,https://pubmed.ncbi.nlm.nih.gov/40560724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,40868276,"Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteostatic Collapse, and Network Failure Across the CNS.",2025,10.3390/biomedicines13082025,https://pubmed.ncbi.nlm.nih.gov/40868276/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,38548861,ELAVL2 loss promotes aggressive mesenchymal transition in glioblastoma.,2024,10.1038/s41698-024-00566-1,https://pubmed.ncbi.nlm.nih.gov/38548861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,39827160,ApoM maintains cellular homeostasis between mitophagy and apoptosis by affecting the stability of Nnt mRNA through the Zic3-ApoM-Elavl2-Nnt axis during neural tube closure.,2025,10.1038/s41419-025-07343-3,https://pubmed.ncbi.nlm.nih.gov/39827160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,37862432,Long 3'UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation.,2023,10.1126/sciimmunol.adg2979,https://pubmed.ncbi.nlm.nih.gov/37862432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,39307290,Role of Elavl-like RNA-binding protein in retinal development and signal transduction.,2025,10.1016/j.bbadis.2024.167518,https://pubmed.ncbi.nlm.nih.gov/39307290/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,34296486,RNA-binding protein ELAVL2 plays post-transcriptional roles in the regulation of spermatogonia proliferation and apoptosis.,2021,10.1111/cpr.13098,https://pubmed.ncbi.nlm.nih.gov/34296486/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,38654363,Unravelling driver genes as potential therapeutic targets in ovarian cancer via integrated bioinformatics approach.,2024,10.1186/s13048-024-01402-7,https://pubmed.ncbi.nlm.nih.gov/38654363/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,37697079,The molecular genetics of nELAVL in brain development and disease.,2023,10.1038/s41431-023-01456-z,https://pubmed.ncbi.nlm.nih.gov/37697079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,40400235,Shared genetics and causal relationship between sociability and the brain's default mode network.,2025,10.1017/s0033291725000832,https://pubmed.ncbi.nlm.nih.gov/40400235/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,39511334,Protein-RNA interaction dynamics reveal key regulators of oncogenic KRAS-driven cancers.,2024,10.1038/s41598-024-78333-2,https://pubmed.ncbi.nlm.nih.gov/39511334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,40361484,Five Cellular Genes as Candidates for Cervical Adenocarcinoma Molecular Markers.,2025,10.3390/cancers17091558,https://pubmed.ncbi.nlm.nih.gov/40361484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,35380695,Sequence and tissue targeting specificity of ZFP36L2 reveals Elavl2 as a novel target with co-regulation potential.,2022,10.1093/nar/gkac209,https://pubmed.ncbi.nlm.nih.gov/35380695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,42297098,From prediction to mechanism: Explainable AI uncovers plasma and CSF proteomic signatures of Alzheimer's disease.,2026,10.1016/j.jprot.2026.105698,https://pubmed.ncbi.nlm.nih.gov/42297098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,34711922,Dynamically expressed single ELAV/Hu orthologue elavl2 of bees is required for learning and memory.,2021,10.1038/s42003-021-02763-1,https://pubmed.ncbi.nlm.nih.gov/34711922/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,39425207,Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer's disease.,2024,10.1186/s13024-024-00771-3,https://pubmed.ncbi.nlm.nih.gov/39425207/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,31285951,Genome-scale CRISPR activation screening identifies a role of ELAVL2-CDKN1A axis in paclitaxel resistance in esophageal squamous cell carcinoma.,2019,,https://pubmed.ncbi.nlm.nih.gov/31285951/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,36005139,1-L Transcription in Alzheimer's Disease.,2022,10.3390/cimb44080243,https://pubmed.ncbi.nlm.nih.gov/36005139/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,32012407,Establishment of epigenetic markers to predict irradiation efficacy against oropharyngeal cancer.,2020,10.1111/cas.14338,https://pubmed.ncbi.nlm.nih.gov/32012407/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,32954318,High-resolution epitope mapping of anti-Hu and anti-Yo autoimmunity by programmable phage display.,2020,10.1093/braincomms/fcaa059,https://pubmed.ncbi.nlm.nih.gov/32954318/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,25303886,Hsa-miR-520d converts fibroblasts into CD105+ populations.,2014,10.1007/s40268-014-0064-6,https://pubmed.ncbi.nlm.nih.gov/25303886/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,29686606,HuR (Elavl1) and HuB (Elavl2) Stabilize Matrix Metalloproteinase-9 mRNA During Seizure-Induced Mmp-9 Expression in Neurons.,2018,10.3389/fnins.2018.00224,https://pubmed.ncbi.nlm.nih.gov/29686606/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,29559929,Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder.,2018,10.3389/fpsyt.2018.00065,https://pubmed.ncbi.nlm.nih.gov/29559929/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,25239644,Genetic polymorphisms in the 9p21 region associated with risk of multiple cancers.,2014,10.1093/carcin/bgu203,https://pubmed.ncbi.nlm.nih.gov/25239644/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,20309390,Olfactory discrimination training up-regulates and reorganizes expression of microRNAs in adult mouse hippocampus.,2010,10.1042/an20090055,https://pubmed.ncbi.nlm.nih.gov/20309390/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELAVL2,ENSG00000107105,Unsafe,17687032,Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium.,2007,10.1523/jneurosci.1269-07.2007,https://pubmed.ncbi.nlm.nih.gov/17687032/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,41797259,VEGF-C-Driven Lymphatic Survival Signaling Promotes Periodontal Repair.,2026,10.1177/00220345261421161,https://pubmed.ncbi.nlm.nih.gov/41797259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,42124334,Maternal genetic variants associated with aneuploid conception: a narrative review.,2026,10.1093/humupd/dmag012,https://pubmed.ncbi.nlm.nih.gov/42124334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,38966291,SMARCB1-Retained and SMARCB1-Deficient SNUC are Genetically Distinct: A Pilot Study Using RNA Sequencing.,2024,10.1055/a-2088-6730,https://pubmed.ncbi.nlm.nih.gov/38966291/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,30654843,Ell3 functions as a critical decision maker at the crossroad between stem cell senescence and apoptosis.,2019,10.1186/s13287-019-1137-9,https://pubmed.ncbi.nlm.nih.gov/30654843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,29082349,Ell3 Modulates the Wound Healing Activity of Conditioned Medium of Adipose-derived Stem Cells.,2017,10.12717/dr.2017.21.3.335,https://pubmed.ncbi.nlm.nih.gov/29082349/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,28588704,Ell3 stimulates 5-FU resistance in a breast cancer cell line.,2017,10.3892/ol.2017.5996,https://pubmed.ncbi.nlm.nih.gov/28588704/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,31775315,MS CD49d+CD154+ Lymphocytes Reprogram Oligodendrocytes into Immune Reactive Cells Affecting CNS Regeneration.,2019,10.3390/cells8121508,https://pubmed.ncbi.nlm.nih.gov/31775315/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,34658793,The Expression and Roles of the Super Elongation Complex in Mouse Cochlear Lgr5+ Progenitor Cells.,2021,10.3389/fncel.2021.735723,https://pubmed.ncbi.nlm.nih.gov/34658793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,28858629,Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival.,2017,10.1016/j.molimm.2017.08.016,https://pubmed.ncbi.nlm.nih.gov/28858629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,28514748,"A transcriptional complex composed of ER(α), GATA3, FOXA1 and ELL3 regulates IL-20 expression in breast cancer cells.",2017,10.18632/oncotarget.17459,https://pubmed.ncbi.nlm.nih.gov/28514748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,26540344,Ell3 stabilizes p53 following CDDP treatment via its effects on ubiquitin-dependent and -independent proteasomal degradation pathways in breast cancer cells.,2015,10.18632/oncotarget.5972,https://pubmed.ncbi.nlm.nih.gov/26540344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,29022001,Data supporting the functional role of Eleven-nineteen Lysine-rich Leukemia 3 (ELL3) in B cell lymphoma cell line cells.,2017,10.1016/j.dib.2017.09.042,https://pubmed.ncbi.nlm.nih.gov/29022001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,23850691,"Ell3 stimulates proliferation, drug resistance, and cancer stem cell properties of breast cancer cells via a MEK/ERK-dependent signaling pathway.",2013,10.1016/j.bbrc.2013.06.114,https://pubmed.ncbi.nlm.nih.gov/23850691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,33719345,Identification and Validation of a Novel DNA Damage and DNA Repair Related Genes Based Signature for Colon Cancer Prognosis.,2021,10.3389/fgene.2021.635863,https://pubmed.ncbi.nlm.nih.gov/33719345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,22768269,Ell3 enhances differentiation of mouse embryonic stem cells by regulating epithelial-mesenchymal transition and apoptosis.,2012,10.1371/journal.pone.0040293,https://pubmed.ncbi.nlm.nih.gov/22768269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,34017580,Identification of key gene modules and pathways of human platelet transcriptome in acute myocardial infarction patients through co-expression network.,2021,,https://pubmed.ncbi.nlm.nih.gov/34017580/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,33057942,Disruption of CTCF Boundary at HOXA Locus Promote BET Inhibitors' Therapeutic Sensitivity in Acute Myeloid Leukemia.,2020,10.1007/s12015-020-10057-y,https://pubmed.ncbi.nlm.nih.gov/33057942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,23273992,The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation.,2013,10.1016/j.cell.2012.12.015,https://pubmed.ncbi.nlm.nih.gov/23273992/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,23050902,Ribavirin-induced intracellular GTP depletion activates transcription elongation in coagulation factor VII gene expression.,2013,10.1042/bj20121286,https://pubmed.ncbi.nlm.nih.gov/23050902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELL3,ENSG00000128886,Unsafe,10882741,"Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3.",2000,10.1074/jbc.m005175200,https://pubmed.ncbi.nlm.nih.gov/10882741/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOA2,ENSG00000206181,Unsafe,40810785,A Novel Prognostic Model of Endometrial Cancer Based on Inflammation and Lipid Metabolism Genes.,2025,10.1177/19450265251366431,https://pubmed.ncbi.nlm.nih.gov/40810785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOA2,ENSG00000206181,Unsafe,39584991,Ocular Mucous Membrane Pemphigoid Demonstrates a Distinct Autoantibody Profile from Those of Other Autoimmune Blistering Diseases: A Preliminary Study.,2024,10.3390/antib13040091,https://pubmed.ncbi.nlm.nih.gov/39584991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOA2,ENSG00000206181,Unsafe,32636717,The plasma peptides of sepsis.,2020,10.1186/s12014-020-09288-5,https://pubmed.ncbi.nlm.nih.gov/32636717/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOA2,ENSG00000206181,Unsafe,10692460,"Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis.",2000,10.1074/jbc.275.9.6546,https://pubmed.ncbi.nlm.nih.gov/10692460/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,42777846,Hepatic ELOVL2 regulates sex differences in mouse heart omega-3 polyunsaturated fatty acid metabolism.,2026,10.1016/j.jnutbio.2026.110511,https://pubmed.ncbi.nlm.nih.gov/42777846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,42523772,Association of the methylation of age-related epigenetic marker ELOVL2 with neurophysiological alterations and immunosenescence during aging and its modulation by the APOE genotype.,2026,10.3389/fimmu.2026.1803497,https://pubmed.ncbi.nlm.nih.gov/42523772/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,41947242,POU2F1 drives cholesterol biosynthesis and lipid remodeling through the DHCR24/ELOVL2 axis in endometrial cancer.,2026,10.1186/s40170-026-00430-9,https://pubmed.ncbi.nlm.nih.gov/41947242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,42225919,Co-overexpression of ELOVL2 and ELOVL5 promotes clear cell renal cell carcinoma progression through LIMK1-mediated cytoskeletal reorganization.,2026,10.1038/s41598-026-55807-z,https://pubmed.ncbi.nlm.nih.gov/42225919/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,42638083,Functional genomic dissection and prediction of body size traits in pigs.,2026,10.1186/s12711-026-01078-1,https://pubmed.ncbi.nlm.nih.gov/42638083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,42723073,Lipid-driven membrane remodeling engages a lysosome-dependent adaptive repair program during retinal aging.,2026,10.1186/s13024-026-00990-w,https://pubmed.ncbi.nlm.nih.gov/42723073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,42001274,Differential expression of Pparγ target genes in testis of rats under theinfluence of paternal trans fatty acid and vitamin-E.,2026,10.22074/cellj.2026.2050175.1770,https://pubmed.ncbi.nlm.nih.gov/42001274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,42263887,SPDEF promotes clear cell renal cell carcinoma progression by transcriptionally activating ELOVL2-mediated lipid metabolic reprogramming.,2026,10.1016/j.bbadis.2026.168315,https://pubmed.ncbi.nlm.nih.gov/42263887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,40991728,Retinal polyunsaturated fatty acid supplementation reverses aging-related vision decline in mice.,2025,10.1126/scitranslmed.ads5769,https://pubmed.ncbi.nlm.nih.gov/40991728/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,42457189,A DHA-Deficient Diet Affects the n-3 LC PUFA Molecular Synthesis Pathway and Fatty Acid Composition in European Sardine (Sardina pilchardus).,2026,10.1002/lipd.70070,https://pubmed.ncbi.nlm.nih.gov/42457189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,42374169,Gene co-expression networks related to intramuscular fatty acid composition across different pig genotypes.,2026,10.1186/s12864-026-13086-y,https://pubmed.ncbi.nlm.nih.gov/42374169/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,42264465,Integrative Multi-Omics Analysis Identifies Novel Enhancer Variants on SSC2 Associated With Backfat Thickness in Landrace Pigs.,2026,10.1002/age.70141,https://pubmed.ncbi.nlm.nih.gov/42264465/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,42314258,Associations between polymorphisms in ELOVL2 and OSBPL8 genes and feed efficiency in meat-type ducks.,2026,10.1016/j.psj.2026.107118,https://pubmed.ncbi.nlm.nih.gov/42314258/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,41975027,The aging epigenome: integrative analyses reveal intersection with Alzheimer's disease.,2026,10.1007/s11357-026-02195-x,https://pubmed.ncbi.nlm.nih.gov/41975027/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,40552308,ELOVL2 mediated stabilization of AR contributes to enzalutamide resistance in prostate cancer.,2025,10.3389/fcell.2025.1598400,https://pubmed.ncbi.nlm.nih.gov/40552308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,42090007,From the lab to lifestyle: epigenetic clocks in personalized aging and health.,2026,10.1007/s10522-026-10447-8,https://pubmed.ncbi.nlm.nih.gov/42090007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,42292292,Compensatory Fatty Acid Metabolism and Hepatic Gene Expression in African Catfish (&lt;i&gt;Clarias gariepinus&lt;/i&gt;) Fed Marine-Ingredient-Free Circular Diets Low in EPA and DHA.,2026,10.1155/anu/4162985,https://pubmed.ncbi.nlm.nih.gov/42292292/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,39199889,Molecular Identification and Functional Characterization of LC-PUFA Biosynthesis Elongase (elovl2) Gene in Chinese Sturgeon (Acipenser sinensis).,2024,10.3390/ani14162343,https://pubmed.ncbi.nlm.nih.gov/39199889/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,42081492,Differences in gene expression may contribute to the racial differences in the risk of MASLD.,2026,10.1371/journal.pone.0345383,https://pubmed.ncbi.nlm.nih.gov/42081492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,42471918,DNA Methylation at Core N-Methyl-D-Aspartate (NMDA) Receptor Genes Reveals a Glutamatergic Signature of Aging in Post-COVID Whole Blood With Implications for Long-COVID Neuropsychiatric Sequelae.,2026,10.7759/cureus.112902,https://pubmed.ncbi.nlm.nih.gov/42471918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,42135634,The relationship between elongation of very long-chain fatty acids (ELOVL) 2 polymorphism rs953413 and blood n-3 HUFA levels: a secondary analysis of EPA treatment in the seAFOod polyp prevention trial.,2026,10.1186/s12263-026-00797-w,https://pubmed.ncbi.nlm.nih.gov/42135634/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,42847863,Tryptophan metabolism-derived prognostic signature: A potential biomarker for risk stratification and exploratory immunotherapy relevance analysis in prostate cancer.,2026,10.1177/00368504261494032,https://pubmed.ncbi.nlm.nih.gov/42847863/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,41289662,"A hexaplex droplet digital PCR assay for DNA methylation-based age prediction from blood samples targeting ELOVL2, FHL2, and TRIM59.",2026,10.1016/j.fsigen.2025.103396,https://pubmed.ncbi.nlm.nih.gov/41289662/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,40024396,"Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population.",2025,10.1016/j.mad.2025.112043,https://pubmed.ncbi.nlm.nih.gov/40024396/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,40934570,Evaluation of developmental and behavioral toxicity of Resmetirom in zebrafish larvae (Danio rerio).,2025,10.1016/j.ecoenv.2025.118929,https://pubmed.ncbi.nlm.nih.gov/40934570/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,40114193,The influence of FADS1 and ELOVL2 genetic polymorphisms on polyunsaturated fatty acid composition in response to fish oil supplementation.,2025,10.1186/s12944-025-02513-w,https://pubmed.ncbi.nlm.nih.gov/40114193/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,41543640,Integrated machine learning and bioinformatic analyses constructed a sulfur metabolism-related breast cancer risk model and identified heat-shock protein A9 as a potential therapeutic target for human breast cancer.,2026,10.1007/s12672-026-04427-0,https://pubmed.ncbi.nlm.nih.gov/41543640/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,41273970,Polystyrene microplastics-induced gut microbiota dysbiosis with altered short chain fatty acid is associated with reproductive physiology and endocrine disorder in female zebrafish.,2025,10.1016/j.jhazmat.2025.140468,https://pubmed.ncbi.nlm.nih.gov/41273970/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,40104714,Construction of a prognostic signature for breast cancer based on genes involved in unsaturated fatty acid biosynthesis.,2025,10.21037/tcr-24-1668,https://pubmed.ncbi.nlm.nih.gov/40104714/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,39794751,Exploring the role of ELOVLs family in lung adenocarcinoma based on bioinformatic analysis and experimental validation.,2025,10.1186/s12885-024-13415-y,https://pubmed.ncbi.nlm.nih.gov/39794751/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,39866460,Comprehensive analysis reveals cholesterol metabolism-related signature for predicting prognosis and guiding individualized treatment of glioma.,2025,10.1016/j.heliyon.2024.e41601,https://pubmed.ncbi.nlm.nih.gov/39866460/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,37483592,Insight of a lipid metabolism prognostic model to identify immune landscape and potential target for retroperitoneal liposarcoma.,2023,10.3389/fimmu.2023.1209396,https://pubmed.ncbi.nlm.nih.gov/37483592/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELOVL2,ENSG00000197977,Unsafe,20937905,ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.,2010,10.1073/pnas.1005572107,https://pubmed.ncbi.nlm.nih.gov/20937905/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELSPBP1,ENSG00000169393,Unsafe,39694081,Single-cell RNA sequencing unveils dynamic transcriptional profiles during the process of donkey spermatogenesis and maturation.,2025,10.1016/j.ygeno.2024.110974,https://pubmed.ncbi.nlm.nih.gov/39694081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELSPBP1,ENSG00000169393,Unsafe,41328241,Proteomic analysis of seminal plasma in Bali-polled bulls: Identifying biomarkers for fertility assessment.,2025,10.5455/javar.2025.l933,https://pubmed.ncbi.nlm.nih.gov/41328241/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELSPBP1,ENSG00000169393,Unsafe,37969811,Profiling of seminal plasma proteins to identify the fertility of Simmental bull with low semen quality.,2023,10.5455/javar.2023.j689,https://pubmed.ncbi.nlm.nih.gov/37969811/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELSPBP1,ENSG00000169393,Unsafe,35663320,The Role of Testosterone in Spermatogenesis: Lessons From Proteome Profiling of Human Spermatozoa in Testosterone Deficiency.,2022,10.3389/fendo.2022.852661,https://pubmed.ncbi.nlm.nih.gov/35663320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELSPBP1,ENSG00000169393,Unsafe,38555737,"MOCS, a novel classifier system integrated multimoics analysis refining molecular subtypes and prognosis for skin melanoma.",2025,10.1080/07391102.2024.2329305,https://pubmed.ncbi.nlm.nih.gov/38555737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELSPBP1,ENSG00000169393,Unsafe,22875906,Epididymosomes transfer epididymal sperm binding protein 1 (ELSPBP1) to dead spermatozoa during epididymal transit in bovine.,2012,10.1095/biolreprod.112.100990,https://pubmed.ncbi.nlm.nih.gov/22875906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELSPBP1,ENSG00000169393,Unsafe,35484731,Comparative high-throughput analysis of sperm membrane proteins from crossbred bulls with contrasting fertility.,2022,10.1111/and.14451,https://pubmed.ncbi.nlm.nih.gov/35484731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELSPBP1,ENSG00000169393,Unsafe,27784933,Gelatin Binding Proteins in Reproductive Physiology.,2016,10.1007/s12088-016-0618-0,https://pubmed.ncbi.nlm.nih.gov/27784933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELSPBP1,ENSG00000169393,Unsafe,26395865,Evidences of Biological Functions of Biliverdin Reductase A in the Bovine Epididymis.,2016,10.1002/jcp.25200,https://pubmed.ncbi.nlm.nih.gov/26395865/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELSPBP1,ENSG00000169393,Unsafe,21323754,Spatial and temporal gene expression of Fn-type II and cysteine-rich secretory proteins in the reproductive tracts and ejaculated sperm of Chinese Meishan pigs.,2011,10.1111/j.1439-0531.2011.01753.x,https://pubmed.ncbi.nlm.nih.gov/21323754/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELSPBP1,ENSG00000169393,Unsafe,26333091,New Insights into the Phylogeny and Gene Context Analysis of Binder of Sperm Proteins (BSPs).,2015,10.1371/journal.pone.0137008,https://pubmed.ncbi.nlm.nih.gov/26333091/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELSPBP1,ENSG00000169393,Unsafe,29148792,Proteomic Markers of Functional Sperm Population in Bovines: Comparison of Low- and High-Density Spermatozoa Following Cryopreservation.,2018,10.1021/acs.jproteome.7b00493,https://pubmed.ncbi.nlm.nih.gov/29148792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELSPBP1,ENSG00000169393,Unsafe,22457431,Binder of sperm 1 and epididymal sperm binding protein 1 are associated with different bull sperm subpopulations.,2012,10.1530/rep-11-0392,https://pubmed.ncbi.nlm.nih.gov/22457431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELSPBP1,ENSG00000169393,Unsafe,19261225,Fibronectin type II-module proteins in the bovine genital tract and their putative role in cell volume control during sperm maturation.,2009,10.1071/rd08209,https://pubmed.ncbi.nlm.nih.gov/19261225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELSPBP1,ENSG00000169393,Unsafe,17307309,Sperm-binding fibronectin type II-module proteins are genetically linked and functionally related.,2007,10.1016/j.gene.2007.01.002,https://pubmed.ncbi.nlm.nih.gov/17307309/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELSPBP1,ENSG00000169393,Unsafe,19952166,Proteomic comparison of detergent-extracted sperm proteins from bulls with different fertility indexes.,2010,10.1530/rep-09-0375,https://pubmed.ncbi.nlm.nih.gov/19952166/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELSPBP1,ENSG00000169393,Unsafe,36539256,Separating the chaff from the wheat: antibody-based removal of DNA-fragmented sperm.,2023,10.1093/humrep/deac260,https://pubmed.ncbi.nlm.nih.gov/36539256/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ELSPBP1,ENSG00000169393,Unsafe,11144225,Novel sperm-binding proteins of epididymal origin contain four fibronectin type II-modules.,2001,10.1002/1098-2795(200101)58:1<88::aid-mrd12>3.0.co;2-d,https://pubmed.ncbi.nlm.nih.gov/11144225/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,41082058,Oncogenic EME1 promotes tumor progression and immune modulation in human cancers with therapeutic targeting potential.,2025,10.1007/s12672-025-03631-8,https://pubmed.ncbi.nlm.nih.gov/41082058/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,41911235,Mms4 chromosomal association reveals functional relationships between meiotic crossover pathways in budding yeast.,2026,10.1371/journal.pgen.1012097,https://pubmed.ncbi.nlm.nih.gov/41911235/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,41532283,Targeting EME1 Increases the Sensitivity of Camptothecin in Nasopharyngeal Carcinoma Cells.,2026,10.1096/fj.202502314rr,https://pubmed.ncbi.nlm.nih.gov/41532283/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,42230595,"Distinct and overlapping roles of MutLγ, Mus81-Mms4, and STR in meiotic Holliday junction processing.",2026,10.1038/s41467-026-73888-2,https://pubmed.ncbi.nlm.nih.gov/42230595/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,41113473,LncRNA-EME1 enhances BRCA1 recruitment and alters repair of DNA damage in cervical cancer radioresistance.,2026,10.1016/j.ncrna.2025.09.006,https://pubmed.ncbi.nlm.nih.gov/41113473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,41841343,Dual-site phosphorylation of SLX4 stabilizes the SLX4-MUS81 interface to promote mitotic SMX assembly and genome protection.,2026,10.1093/nar/gkag195,https://pubmed.ncbi.nlm.nih.gov/41841343/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,42553536,Integrating genomic structural equation modeling and experimental validation to unravel the genetic basis of male genital lichen sclerosus.,2026,10.3389/fimmu.2026.1857945,https://pubmed.ncbi.nlm.nih.gov/42553536/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,39994444,SETD1A-dependent EME1 transcription drives PARPi sensitivity in HR deficient tumour cells.,2025,10.1038/s41416-025-02963-0,https://pubmed.ncbi.nlm.nih.gov/39994444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,41805125,Cruciform-forming AT/TA repeats are acted upon by structure-selective endonucleases and Rad51 prior to repositioning to the nuclear periphery for repair.,2026,10.1093/nar/gkag217,https://pubmed.ncbi.nlm.nih.gov/41805125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,38305603,A comprehensive analysis of essential meiotic endonuclease 1 to prognosis and immune infiltration in kidney renal clear cell carcinoma.,2024,10.26355/eurrev_202401_35056,https://pubmed.ncbi.nlm.nih.gov/38305603/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,42130070,Phosphorylation by CDK1 switches the function of the human SLX4 SAP domain from DNA binding to MUS81 binding.,2026,10.1093/nar/gkag442,https://pubmed.ncbi.nlm.nih.gov/42130070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,37564211,FIBP interacts with transcription factor STAT3 to induce EME1 expression and drive radioresistance in lung adenocarcinoma.,2023,10.7150/ijbs.83134,https://pubmed.ncbi.nlm.nih.gov/37564211/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,40333587,ESSENTIAL MEIOTIC ENDONUCLEASE 1 is required for chloroplast development and DNA repair in rice.,2025,10.1111/pbi.70101,https://pubmed.ncbi.nlm.nih.gov/40333587/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,42353873,Non-Coding RNAs as Emerging Biomarkers in HPV-Associated Cervical Precancer and Cancer: Molecular Mechanisms and Clinical Perspectives.,2026,10.3390/genes17060714,https://pubmed.ncbi.nlm.nih.gov/42353873/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,36281338,"The Glu69Asp Polymorphism of EME1 Gene is Associated with an Increased Risk of Hepatocellular Carcinoma in Guangxi Population, China.",2022,10.2147/ijgm.s383261,https://pubmed.ncbi.nlm.nih.gov/36281338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,39726587,m6A methylation profiling as a prognostic marker in nasopharyngeal carcinoma: insights from MeRIP-Seq and RNA-Seq.,2024,10.3389/fimmu.2024.1492648,https://pubmed.ncbi.nlm.nih.gov/39726587/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,40594858,Dbl2 interacts with helicases and an endonuclease to maintain the integrity of repetitive regions.,2025,10.1038/s41598-025-08626-7,https://pubmed.ncbi.nlm.nih.gov/40594858/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,39382813,Development and validation of a prognostic model for colon cancer based on mitotic gene signatures and immune microenvironment analysis.,2024,10.1007/s12672-024-01421-2,https://pubmed.ncbi.nlm.nih.gov/39382813/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,40864792,"Homologous Recombination Deficiency in Ovarian and Breast Cancers: Biomarkers, Diagnosis, and Treatment.",2025,10.3390/cimb47080638,https://pubmed.ncbi.nlm.nih.gov/40864792/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,34719326,Essential meiotic structure-specific endonuclease1 (EME1) promotes malignant features in gastric cancer cells via the Akt/GSK3B/CCND1 pathway.,2021,10.1080/21655979.2021.1999371,https://pubmed.ncbi.nlm.nih.gov/34719326/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,39718835,CRISPR/Cas9 screens identify LIG1 as a sensitizer of PARP inhibitors in castration-resistant prostate cancer.,2024,10.1172/jci179393,https://pubmed.ncbi.nlm.nih.gov/39718835/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,35559013,Homologous Recombination Related Signatures Predict Prognosis and Immunotherapy Response in Metastatic Urothelial Carcinoma.,2022,10.3389/fgene.2022.875128,https://pubmed.ncbi.nlm.nih.gov/35559013/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,35656315,A DNA Damage Repair Gene Signature Associated With Immunotherapy Response and Clinical Prognosis in Clear Cell Renal Cell Carcinoma.,2022,10.3389/fgene.2022.798846,https://pubmed.ncbi.nlm.nih.gov/35656315/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,36091160,Comprehensive analysis to identify a novel PTEN-associated ceRNA regulatory network as a prognostic biomarker for lung adenocarcinoma.,2022,10.3389/fonc.2022.923026,https://pubmed.ncbi.nlm.nih.gov/36091160/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,33833336,"The benzylisoquinoline alkaloids, berberine and coptisine, act against camptothecin-resistant topoisomerase I mutants.",2021,10.1038/s41598-021-87344-2,https://pubmed.ncbi.nlm.nih.gov/33833336/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,27354282,SLX4-SLX1 Protein-independent Down-regulation of MUS81-EME1 Protein by HIV-1 Viral Protein R (Vpr).,2016,10.1074/jbc.m116.721183,https://pubmed.ncbi.nlm.nih.gov/27354282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,29898918,Mutations that prevent methylation of cohesin render sensitivity to DNA damage in S. pombe.,2018,10.1242/jcs.214924,https://pubmed.ncbi.nlm.nih.gov/29898918/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,29739952,Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma.,2018,10.1038/s41598-018-24232-2,https://pubmed.ncbi.nlm.nih.gov/29739952/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,32234060,Investigation of the immunogenicity of Zika glycan loop.,2020,10.1186/s12985-020-01313-1,https://pubmed.ncbi.nlm.nih.gov/32234060/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,25030699,A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication.,2014,10.1101/gad.240515.114,https://pubmed.ncbi.nlm.nih.gov/25030699/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,30520126,Rapid and accurate structure-based therapeutic peptide design using GPU accelerated thermodynamic integration.,2019,10.1002/prot.25644,https://pubmed.ncbi.nlm.nih.gov/30520126/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,30479332,Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation.,2018,10.1038/s41467-018-07364-x,https://pubmed.ncbi.nlm.nih.gov/30479332/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EME1,ENSG00000154920,Unsafe,26867983,Radiosensitisation of human colorectal cancer cells by ruthenium(II) arene anticancer complexes.,2016,10.1038/srep20596,https://pubmed.ncbi.nlm.nih.gov/26867983/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,42345951,Integrative Analysis of &lt;i&gt;ENAM rs3796704&lt;/i&gt; Polymorphism and Eugenol-Cinnamic Acid Docking/ADMET Against Biofilm-Forming &lt;i&gt;Streptococcus Mutans&lt;/i&gt;: Genetic-Phytochemical Links to Oral Dysbiosis.,2026,10.3390/dj14060360,https://pubmed.ncbi.nlm.nih.gov/42345951/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,42594261,A Novel FAM83H Truncation Mutation Disrupts Enamel Mineralization in Autosomal Dominant Hypocalcified Amelogenesis Imperfecta.,2026,10.1002/cre2.70431,https://pubmed.ncbi.nlm.nih.gov/42594261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,38716742,&lt;i&gt;ENAM&lt;/i&gt; Mutations Can Cause Hypomaturation Amelogenesis Imperfecta.,2024,10.1177/00220345241236695,https://pubmed.ncbi.nlm.nih.gov/38716742/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,39859478,"Expression of AMELX, AMBN, ENAM, TUFT1, FAM83H and MMP20 Genes in Buccal Epithelial Cells from Patients with Molar Incisor Hypomineralization (MIH)-A Pilot Study.",2025,10.3390/ijms26020766,https://pubmed.ncbi.nlm.nih.gov/39859478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,40318225,Functions of secretory calcium-binding phosphoproteins in dental mineralization.,2025,10.1093/jbmr/zjaf062,https://pubmed.ncbi.nlm.nih.gov/40318225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,40903061,[Single-cell sequencing reveals the temporal expression characteristics of key molecules related to tooth agenesis and dental hard tissues in mouse molars].,2025,10.3769/cma.j.cn112144-20250605-00206,https://pubmed.ncbi.nlm.nih.gov/40903061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,39901093,Exploring proteomic immunoprofiles: common neurological and immunological pathways in multiple sclerosis and type 1 diabetes mellitus.,2025,10.1186/s10020-025-01084-x,https://pubmed.ncbi.nlm.nih.gov/39901093/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,41669845,Circular Potential of Lithium-Ion Battery Recycling Slags: Quantifying Microstructure and Elemental Distribution for a Holistic Valorization.,2026,10.1002/advs.202523988,https://pubmed.ncbi.nlm.nih.gov/41669845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,40768595,Sex Identification and Species Confirmation in Modern and Archeological Caprine Enamel.,2025,10.1021/acs.jproteome.5c00012,https://pubmed.ncbi.nlm.nih.gov/40768595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,40773061,Reduction of Tooth Replacement Disproportionately Affects the Evolution of Enamel Matrix Proteins.,2025,10.1007/s00239-025-10258-4,https://pubmed.ncbi.nlm.nih.gov/40773061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,40416342,&lt;i&gt;Nkx2-3&lt;/i&gt; Homeobox Gene Plays an Essential Role in Later Stages of Orofacial Differentiation.,2025,10.47739/pediatrics.1347,https://pubmed.ncbi.nlm.nih.gov/40416342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,37191055,Enam expression is regulated by Msx2.,2023,10.1002/dvdy.598,https://pubmed.ncbi.nlm.nih.gov/37191055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,38883909,"Polymorphisms in ENAM, AMBN, and KLK4 predispose Egyptian adults to dental caries: A cross-sectional study.",2024,10.1016/j.sdentj.2024.03.014,https://pubmed.ncbi.nlm.nih.gov/38883909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,40725478,Integrating Imaging and Genomics in Amelogenesis Imperfecta: A Novel Diagnostic Approach.,2025,10.3390/genes16070822,https://pubmed.ncbi.nlm.nih.gov/40725478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,39955953,Potential of human dental pulp stem cell-derived conditioned medium for amelo-/odontoblastic differentiation of HERS/ERM cells.,2025,10.1016/j.bbrc.2025.151490,https://pubmed.ncbi.nlm.nih.gov/39955953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,37985977,Splicing mutations in AMELX and ENAM cause amelogenesis imperfecta.,2023,10.1186/s12903-023-03508-8,https://pubmed.ncbi.nlm.nih.gov/37985977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,38172607,The Rogdi knockout mouse is a model for Kohlschütter-Tönz syndrome.,2024,10.1038/s41598-023-50870-2,https://pubmed.ncbi.nlm.nih.gov/38172607/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,41210864,Comprehensive genetic screening of 70 severe adolescent idiopathic scoliosis probands reveals novel pathogenic variants and syndromic associations.,2025,10.3389/fmed.2025.1646415,https://pubmed.ncbi.nlm.nih.gov/41210864/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,39273410,Salivary Molecular Spectroscopy with Machine Learning Algorithms for a Diagnostic Triage for Amelogenesis Imperfecta.,2024,10.3390/ijms25179464,https://pubmed.ncbi.nlm.nih.gov/39273410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,35820561,The phosphorylation of serine&lt;sup&gt;55&lt;/sup&gt; in enamelin is essential for murine amelogenesis.,2022,10.1016/j.matbio.2022.07.001,https://pubmed.ncbi.nlm.nih.gov/35820561/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,36579450,Factors associated with medical students’ scores on the National Licensing Exam in Peru: a systematic review,2022,10.3352/jeehp.2022.19.38,https://pubmed.ncbi.nlm.nih.gov/36579450/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,33539322,ENAM gene associated with T classification and inhibits proliferation in renal clear cell carcinoma.,2021,10.18632/aging.202558,https://pubmed.ncbi.nlm.nih.gov/33539322/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,39518852,Population Structure and Selection Signatures in Chinese Indigenous Zhaotong Pigs Revealed by Whole-Genome Resequencing.,2024,10.3390/ani14213129,https://pubmed.ncbi.nlm.nih.gov/39518852/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,30970175,Adaptation of a mental development assessment tool for the evaluation of the long-term effect of a successful nutrition intervention in Ghana.,2019,10.1111/mcn.12829,https://pubmed.ncbi.nlm.nih.gov/30970175/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,32789468,Profiles of overall survival-related gene expression-based risk signature and their prognostic implications in clear cell renal cell carcinoma.,2020,10.1042/bsr20200492,https://pubmed.ncbi.nlm.nih.gov/32789468/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,25373699,Effects of enamel matrix genes on dental caries are moderated by fluoride exposures.,2015,10.1007/s00439-014-1504-7,https://pubmed.ncbi.nlm.nih.gov/25373699/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,20531944,The acid test of fluoride: how pH modulates toxicity.,2010,10.1371/journal.pone.0010895,https://pubmed.ncbi.nlm.nih.gov/20531944/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,11233387,"A randomized, controlled, multicenter study to compare prazosin GITS with enalapril in hypertensive patients with diabetes mellitus. Bombay Hypertension Study Group.",1998,,https://pubmed.ncbi.nlm.nih.gov/11233387/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENAM,ENSG00000132464,Unsafe,11487571,"Mutation of the gene encoding the enamel-specific protein, enamelin, causes autosomal-dominant amelogenesis imperfecta.",2001,10.1093/hmg/10.16.1673,https://pubmed.ncbi.nlm.nih.gov/11487571/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,41869437,ENDONUCLEASE V: FROM TRANSCRIPTOME REGULATOR TO CHEMICAL BIOLOGY TOOL.,2026,10.1002/ceur.202500444,https://pubmed.ncbi.nlm.nih.gov/41869437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,42405764,EndoV does not measurably affect TadA-dependent A-to-I RNA editing in &lt;i&gt;Escherichia coli&lt;/i&gt; under exponential-growth conditions in rich medium.,2026,10.1128/spectrum.01302-26,https://pubmed.ncbi.nlm.nih.gov/42405764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,42004038,A bacteriophage-encoded protein gp119 suppresses deoxyinosine repair to protect hypermutated viral genome.,2026,10.1016/j.isci.2026.115532,https://pubmed.ncbi.nlm.nih.gov/42004038/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,40191489,Genetic Markers of Spina Bifida: Enrichment of Pathogenic Variants and Variants of Uncertain Significance.,2025,10.4103/jiaps.jiaps_193_24,https://pubmed.ncbi.nlm.nih.gov/40191489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,42533231,Integrated transcriptome and metabolome analysis of the differential regulation of physiological metabolism in passion fruit by different MeJA concentrations.,2026,10.1007/s11103-026-01748-0,https://pubmed.ncbi.nlm.nih.gov/42533231/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,39071059,Spatial Visualization of A-to-I Editing in Cells Using Endonuclease V Immunostaining Assay (EndoVIA).,2024,10.1021/acscentsci.4c00444,https://pubmed.ncbi.nlm.nih.gov/39071059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,34259011,Endonuclease V Regulates Atherosclerosis Through C-C Motif Chemokine Ligand 2-Mediated Monocyte Infiltration.,2021,10.1161/jaha.120.020656,https://pubmed.ncbi.nlm.nih.gov/34259011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,37288313,Genome-phenome wide association study of broadly defined headache.,2023,10.1093/braincomms/fcad167,https://pubmed.ncbi.nlm.nih.gov/37288313/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,39654522,Search for germline gene variants in colorectal cancer families presenting with multiple primary colorectal cancers.,2025,10.1002/ijc.35283,https://pubmed.ncbi.nlm.nih.gov/39654522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,32083667,Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma.,2020,10.1093/nar/gkaa115,https://pubmed.ncbi.nlm.nih.gov/32083667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,31703097,"Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform.",2019,10.1371/journal.pone.0225081,https://pubmed.ncbi.nlm.nih.gov/31703097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,33979483,Direct Immunodetection of Global A-to-I RNA Editing Activity with a Chemiluminescent Bioassay.,2021,10.1002/anie.202102762,https://pubmed.ncbi.nlm.nih.gov/33979483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,39720842,How Can One Metal Power Nucleic Acid Phosphodiester Bond Cleavage by a Nuclease? Multiscale Computational Studies Highlight a Diverse Mechanistic Landscape.,2025,10.1021/acs.jpcb.4c05875,https://pubmed.ncbi.nlm.nih.gov/39720842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,35900335,Harnessing Nature's Molecular Recognition Capabilities to Map and Study RNA Modifications.,2022,10.1021/acs.accounts.2c00287,https://pubmed.ncbi.nlm.nih.gov/35900335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,35887335,Exploring C-to-G and A-to-Y Base Editing in Rice by Using New Vector Tools.,2022,10.3390/ijms23147990,https://pubmed.ncbi.nlm.nih.gov/35887335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,36793865,Human papillomavirus E6/E7 oncoproteins promote radiotherapy-mediated tumor suppression by globally hijacking host DNA damage repair.,2023,10.7150/thno.78091,https://pubmed.ncbi.nlm.nih.gov/36793865/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,36713553,Construction of a DNA damage repair gene signature for predicting prognosis and immune response in breast cancer.,2022,10.3389/fonc.2022.1085632,https://pubmed.ncbi.nlm.nih.gov/36713553/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,30622278,Genome-wide profiling of adenine base editor specificity by EndoV-seq.,2019,10.1038/s41467-018-07988-z,https://pubmed.ncbi.nlm.nih.gov/30622278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,31444105,Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase.,2019,10.1016/j.molcel.2019.06.046,https://pubmed.ncbi.nlm.nih.gov/31444105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,34531846,Repair of Hypoxanthine in DNA Revealed by DNA Glycosylases and Endonucleases From Hyperthermophilic Archaea.,2021,10.3389/fmicb.2021.736915,https://pubmed.ncbi.nlm.nih.gov/34531846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,27829633,A Label-free Time-resolved Luminescent Platform for Sensitive Endonuclease V Detection Based on Exonuclease III Regulated DNA-Tb3+ Luminescence.,2016,10.2116/analsci.32.1245,https://pubmed.ncbi.nlm.nih.gov/27829633/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,19943897,Production of clastogenic DNA precursors by the nucleotide metabolism in Escherichia coli.,2010,10.1111/j.1365-2958.2009.06994.x,https://pubmed.ncbi.nlm.nih.gov/19943897/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENDOV,ENSG00000173818,Unsafe,9427764,Site-specific repair of cyclobutane pyrimidine dimers in a positioned nucleosome by photolyase and T4 endonuclease V in vitro.,1998,10.1093/emboj/17.1.306,https://pubmed.ncbi.nlm.nih.gov/9427764/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,41723778,Unravelling Synaptic and Metabolic Mechanisms of Cognitive Resilience in Asymptomatic Alzheimer's Disease Across Two Alzheimer's Disease Cohorts.,2026,10.1007/s10571-026-01700-2,https://pubmed.ncbi.nlm.nih.gov/41723778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,40597679,Exploring ENPP5 as a diagnostic biomarker for sepsis: a comprehensive bioinformatics analysis.,2025,10.1186/s12879-025-11152-6,https://pubmed.ncbi.nlm.nih.gov/40597679/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,40457511,"A Novel Skeletal Dysplasia With Premaxilla Overgrowth, Gingival Hyperplasia, and Dental Hypercementosis.",2025,10.1111/cge.14779,https://pubmed.ncbi.nlm.nih.gov/40457511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,40827287,Identification of novel drug targets for primary open angle glaucoma and its potential side-effects by human plasma proteome.,2025,10.18240/ijo.2025.08.07,https://pubmed.ncbi.nlm.nih.gov/40827287/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,38436793,"Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging.",2024,10.1007/s10522-024-10096-9,https://pubmed.ncbi.nlm.nih.gov/38436793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,39962083,Association of escitalopram-induced shifts in gut microbiota and sphingolipid metabolism with depression-like behavior in wistar-kyoto rats.,2025,10.1038/s41398-025-03277-8,https://pubmed.ncbi.nlm.nih.gov/39962083/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,40823751,"Comparisons of miRNA profiles of exosomes derived from human iPSCs, ADSCs, and BMSCs and effects on chondrocyte function.",2025,10.1302/2046-3758.148.bjr-2024-0267.r4,https://pubmed.ncbi.nlm.nih.gov/40823751/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,40167410,Causal Associations of Insomnia With Chronic Kidney Diseases and Underlying Blood Proteins: An Observational and Mendelian Randomization Study.,2025,10.1016/j.mayocp.2024.12.020,https://pubmed.ncbi.nlm.nih.gov/40167410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,41534648,Exploring the molecular intersections of osteoporosis and sarcopenia: An integrated bioinformatics and experimental validation.,2026,10.1016/j.exger.2026.113033,https://pubmed.ncbi.nlm.nih.gov/41534648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,37352273,New oncogenic functions of LINE1 retroelement as a ceRNA for tumor suppressive microRNA miR-126 on ENPP5.,2023,10.1371/journal.pone.0286814,https://pubmed.ncbi.nlm.nih.gov/37352273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,38015522,Identification of potential diagnostic biomarkers and immune infiltration features in diabetic foot ulcer by bioinformatics analysis and validation.,2023,10.14715/cmb/2023.69.11.27,https://pubmed.ncbi.nlm.nih.gov/38015522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,37822091,miRNAs from Inflamed Gingiva Link Gene Signaling to Increased MET Expression.,2023,10.1177/00220345231197984,https://pubmed.ncbi.nlm.nih.gov/37822091/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,39641818,Free amino acids accelerate the time-dependent inactivation of rat liver nucleotide pyrophosphatase/phosphodiesterase Enpp3 elicited by EDTA.,2024,10.1007/s00726-024-03431-4,https://pubmed.ncbi.nlm.nih.gov/39641818/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,37689589,Deciphering the implications of mitophagy-related signatures in clinical outcomes and microenvironment heterogeneity of clear cell renal cell carcinoma.,2023,10.1007/s00432-023-05349-y,https://pubmed.ncbi.nlm.nih.gov/37689589/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,34958798,Structure and function of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family: Tidying up diversity.,2022,10.1016/j.jbc.2021.101526,https://pubmed.ncbi.nlm.nih.gov/34958798/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,31514170,Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice.,2019,10.18632/aging.102275,https://pubmed.ncbi.nlm.nih.gov/31514170/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,28914974,Mucocutaneous inflammation in the Ikaros Family Zinc Finger 1-keratin 5-specific transgenic mice.,2018,10.1111/all.13308,https://pubmed.ncbi.nlm.nih.gov/28914974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,30678306,Integrative Analyses of Genes Associated with Subcutaneous Insulin Resistance.,2019,10.3390/biom9020037,https://pubmed.ncbi.nlm.nih.gov/30678306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,22311740,CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma.,2012,10.1007/s00401-012-0952-1,https://pubmed.ncbi.nlm.nih.gov/22311740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,30157312,Genome-wide association study and identification of chromosomal enhancer maps in multiple brain regions related to autism spectrum disorder.,2019,10.1002/aur.2001,https://pubmed.ncbi.nlm.nih.gov/30157312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENPP5,ENSG00000112796,Unsafe,34335696,Identification of Genomic Regions Influencing N-Metabolism and N-Excretion in Lactating Holstein- Friesians.,2021,10.3389/fgene.2021.699550,https://pubmed.ncbi.nlm.nih.gov/34335696/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENTPD4,ENSG00000197217,Unsafe,38773214,Uracil as a biomarker for spatial pyrimidine metabolism in the development of gingivobuccal oral squamous cell carcinoma.,2024,10.1038/s41598-024-62434-z,https://pubmed.ncbi.nlm.nih.gov/38773214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENTPD4,ENSG00000197217,Unsafe,41751043,"Genome Imputation for Genome-Wide Association Study of Reproductive Traits in Chinese Duroc, Landrace, and Yorkshire Pigs: Strategy and Validation.",2026,10.3390/ani16040583,https://pubmed.ncbi.nlm.nih.gov/41751043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENTPD4,ENSG00000197217,Unsafe,39828062,"Exploring gene expression, alternative splicing events and RNA-binding proteins changes in PBMC from patients with hyperuricemia.",2025,10.1016/j.gene.2025.149256,https://pubmed.ncbi.nlm.nih.gov/39828062/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENTPD4,ENSG00000197217,Unsafe,40389926,A novel neutrophil extracellular traps related diagnostic signature for intracranial aneurysm.,2025,10.1186/s12883-025-04068-w,https://pubmed.ncbi.nlm.nih.gov/40389926/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENTPD4,ENSG00000197217,Unsafe,32767432,Crystal structure of the nucleotide-metabolizing enzyme NTPDase4.,2020,10.1002/pro.3926,https://pubmed.ncbi.nlm.nih.gov/32767432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENTPD4,ENSG00000197217,Unsafe,31997941,Circular RNA ATXN7 promotes the development of gastric cancer through sponging miR-4319 and regulating ENTPD4.,2020,10.1186/s12935-020-1106-5,https://pubmed.ncbi.nlm.nih.gov/31997941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENTPD4,ENSG00000197217,Unsafe,20537721,"An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia.",2011,10.1016/j.psychres.2009.09.018,https://pubmed.ncbi.nlm.nih.gov/20537721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENTPD4,ENSG00000197217,Unsafe,26367535,Identification of Genes Whose Expression Profile Is Associated with Non-Progression towards AIDS Using eQTLs.,2015,10.1371/journal.pone.0136989,https://pubmed.ncbi.nlm.nih.gov/26367535/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENTPD4,ENSG00000197217,Unsafe,24672025,NTPDASE4 gene products cooperate with the adenovirus E4orf4 protein through PP2A-dependent and -independent mechanisms and contribute to induction of cell death.,2014,10.1128/jvi.00381-14,https://pubmed.ncbi.nlm.nih.gov/24672025/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENTPD4,ENSG00000197217,Unsafe,15200686,The VSFASSQQ motif confers calcium sensitivity to the intracellular apyrase LALP70.,2004,10.1186/1471-2091-5-8,https://pubmed.ncbi.nlm.nih.gov/15200686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENTPD4,ENSG00000197217,Unsafe,16227198,YND1 interacts with CDC55 and is a novel mediator of E4orf4-induced toxicity.,2005,10.1074/jbc.m507281200,https://pubmed.ncbi.nlm.nih.gov/16227198/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENTPD4,ENSG00000197217,Unsafe,10858452,First apyrase splice variants have different enzymatic properties.,2000,10.1074/jbc.m001245200,https://pubmed.ncbi.nlm.nih.gov/10858452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENTPD4,ENSG00000197217,Unsafe,10393803,"A human intracellular apyrase-like protein, LALP70, localizes to lysosomal/autophagic vacuoles.",1999,10.1242/jcs.112.15.2473,https://pubmed.ncbi.nlm.nih.gov/10393803/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ENTPD4,ENSG00000197217,Unsafe,9556635,Golgi localization and functional expression of human uridine diphosphatase.,1998,10.1074/jbc.273.18.11392,https://pubmed.ncbi.nlm.nih.gov/9556635/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,41909879,"Identification of STEAP4, EPC1, and CLEC1B as non-invasive candidate biomarkers for hepatocellular carcinoma using integrated bioinformatics analysis.",2026,10.1016/j.btre.2026.e00953,https://pubmed.ncbi.nlm.nih.gov/41909879/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,41672495,Preparation and MR Imaging Study of a Recombinant Surface Antibody Superparamagnetic Iron Oxide Nanoparticle-EPC1 Molecular Probe for Hepatic Alveolar Echinococcosis.,2026,10.2463/mrms.mp.2025-0096,https://pubmed.ncbi.nlm.nih.gov/41672495/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,41670399,CCER1 condensates participate in histone-to-protamine transition by recruiting the TIP60/EPC1/NuA4 acetyltransferase complex.,2026,10.1242/dev.205326,https://pubmed.ncbi.nlm.nih.gov/41670399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,42531733,"Dynamic evolution of chaperone-mediated autophagy is associated with tumor microenvironment remodeling and prognostic stratification in lung adenocarcinoma: insights from single-cell transcriptomics, ensemble machine learning, and experimental validation.",2026,10.1016/j.tranon.2026.102919,https://pubmed.ncbi.nlm.nih.gov/42531733/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,40886440,The genetic structure and selective sweep analysis of meat pigeon breeds raised in Hainan using whole genome resequencing technology.,2025,10.1016/j.psj.2025.105731,https://pubmed.ncbi.nlm.nih.gov/40886440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,41095698,A Pilot Study of Exploring miRNA-Protein Interaction Networks in Pancreatic Ductal Adenocarcinoma Patients: Implications for Diagnosis and Prognosis.,2025,10.3390/diagnostics15192479,https://pubmed.ncbi.nlm.nih.gov/41095698/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,40346912,Paratesticular Endometrial Stromal Sarcoma-Like Sarcoma With EPC1-SUZ12 Fusion.,2025,10.1002/gcc.70052,https://pubmed.ncbi.nlm.nih.gov/40346912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,39704199,Ossifying fibromyxoid tumours with lipomatous and cartilaginous differentiation: A diagnostic pitfall.,2025,10.1111/his.15396,https://pubmed.ncbi.nlm.nih.gov/39704199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,38439957,EPC1/2 regulate hematopoietic stem and progenitor cell proliferation by modulating H3 acetylation and DLST.,2024,10.1016/j.isci.2024.109263,https://pubmed.ncbi.nlm.nih.gov/38439957/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,42302912,"Clinicopathological, Molecular, and DNA Methylation Analysis of Ossifying Fibromyxoid Tumors Delineates the ZC3H7B::BCOR Subset as a Distinct Entity.",2026,10.1016/j.modpat.2026.101025,https://pubmed.ncbi.nlm.nih.gov/42302912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,39985977,A Di-aptamer-functionalized scaffold promotes bone regeneration by facilitating the selective retention of MSCs and EPCs and then promoting crosstalk between osteogenesis and angiogenesis.,2025,10.1016/j.biomaterials.2025.123197,https://pubmed.ncbi.nlm.nih.gov/39985977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,35366241,Hypoxic pretreatment of adipose-derived stem cell exosomes improved cognition by delivery of circ-Epc1 and shifting microglial M1/M2 polarization in an Alzheimer's disease mice model.,2022,10.18632/aging.203989,https://pubmed.ncbi.nlm.nih.gov/35366241/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,41706043,High-grade endometrial stromal sarcoma is closely related to BCOR-altered sarcomas of the soft tissue and kidney rather than to other uterine sarcomas: implications for uterine sarcoma classification.,2026,10.1002/path.70024,https://pubmed.ncbi.nlm.nih.gov/41706043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,39367284,A potential conundrum in dermatopathology: molecularly confirmed superficial ossifying fibromyxoid tumors with unusual histomorphologic findings and a novel fusion.,2024,10.1007/s00428-024-03895-5,https://pubmed.ncbi.nlm.nih.gov/39367284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,39334892,Modeling Epithelial Homeostasis and Perturbation in Three-Dimensional Human Esophageal Organoids.,2024,10.3390/biom14091126,https://pubmed.ncbi.nlm.nih.gov/39334892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,36158885,Multiomics Integrative Analysis Identifying EPC1 as a Prognostic Biomarker in Head and Neck Squamous Cell Carcinoma.,2022,10.1155/2022/1074412,https://pubmed.ncbi.nlm.nih.gov/36158885/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,40865919,Uterine Sarcomas With Recurrent KDM2B Gene Fusions: Three Cases of a Possible Novel Subtype of High-Grade Endometrial Stromal Sarcoma.,2025,10.1016/j.modpat.2025.100872,https://pubmed.ncbi.nlm.nih.gov/40865919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,36445224,Expanding the molecular spectrum of gene fusions in endometrial stromal sarcoma: Novel subunits of the chromatin remodeling complexes PRC2 and NuA4/TIP60 as alternative fusion partners.,2023,10.1002/gcc.23109,https://pubmed.ncbi.nlm.nih.gov/36445224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,39250713,PHF1::TFE3-positive fibromyxoid sarcoma? Report of 2 cases and review of 13 cases of PHF1::TFE3-positive ossifying fibromyxoid tumor in the literature.,2025,10.1093/ajcp/aqae114,https://pubmed.ncbi.nlm.nih.gov/39250713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,34841830,Expression and Biological Functions of EPC1 in Nasopharyngeal Carcinoma.,2021,10.34172/aim.2021.125,https://pubmed.ncbi.nlm.nih.gov/34841830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,32966340,Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes.,2020,10.1371/journal.pone.0239625,https://pubmed.ncbi.nlm.nih.gov/32966340/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,37658696,Untying the Gordian knot of composite hemangioendothelioma: Discovery of novel fusions.,2024,10.1002/gcc.23198,https://pubmed.ncbi.nlm.nih.gov/37658696/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,34199909,Nrf2/Keap1-Pathway Activation and Reduced Susceptibility to Chemotherapy Treatment by Acidification in Esophageal Adenocarcinoma Cells.,2021,10.3390/cancers13112806,https://pubmed.ncbi.nlm.nih.gov/34199909/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,33221751,Development and validation of a nomogram with an epigenetic signature for predicting survival in patients with lung adenocarcinoma.,2020,10.18632/aging.104090,https://pubmed.ncbi.nlm.nih.gov/33221751/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,25755723,RNA interference targeting enhancer of polycomb1 exerts anti-tumor effects in lung cancer.,2015,,https://pubmed.ncbi.nlm.nih.gov/25755723/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,26350215,Epigenetic factor EPC1 is a master regulator of DNA damage response by interacting with E2F1 to silence death and activate metastasis-related gene signatures.,2016,10.1093/nar/gkv885,https://pubmed.ncbi.nlm.nih.gov/26350215/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,31905726,Loss of Ing3 Expression Results in Growth Retardation and Embryonic Death.,2019,10.3390/cancers12010080,https://pubmed.ncbi.nlm.nih.gov/31905726/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,24166297,Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells.,2014,10.1038/leu.2013.316,https://pubmed.ncbi.nlm.nih.gov/24166297/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,19484761,Alteration of enhancer of polycomb 1 at 10p11.2 is one of the genetic events leading to development of adult T-cell leukemia/lymphoma.,2009,10.1002/gcc.20681,https://pubmed.ncbi.nlm.nih.gov/19484761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,28464914,Efficacy of radiotherapy for the treatment of cystic echinococcosis in naturally infected sheep.,2017,10.1186/s40249-017-0301-7,https://pubmed.ncbi.nlm.nih.gov/28464914/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,29755455,RNAi-Based Identification of Gene-Specific Nuclear Cofactor Networks Regulating Interleukin-1 Target Genes.,2018,10.3389/fimmu.2018.00775,https://pubmed.ncbi.nlm.nih.gov/29755455/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,20734129,Neuroprotective effects of active ingredients isolated from Pegasus laternarius on cultured cerebral neurons.,2011,10.1007/s10571-010-9555-3,https://pubmed.ncbi.nlm.nih.gov/20734129/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPC1,ENSG00000120616,Unsafe,23736028,Functional and cancer genomics of ASXL family members.,2013,10.1038/bjc.2013.281,https://pubmed.ncbi.nlm.nih.gov/23736028/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,42528818,"Gut microbiota induces immune-related alterations in gene expression, RNA methylation, and metabolism in glioblastoma revealed by single-cell and spatial multi-omics.",2026,10.3389/fimmu.2026.1899954,https://pubmed.ncbi.nlm.nih.gov/42528818/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,42434232,Identification of telomere-related genes in the progression of colon adenocarcinoma: a bioinformatics analysis.,2026,10.21037/jgo-2025-1-1075,https://pubmed.ncbi.nlm.nih.gov/42434232/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,42239799,Spatiotemporal patterns of gene expression changes in the mouse dentate gyrus following entorhinal denervation.,2026,10.3389/fnmol.2026.1758390,https://pubmed.ncbi.nlm.nih.gov/42239799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,39415254,Illuminating the dark kinome: utilizing multiplex peptide activity arrays to functionally annotate understudied kinases.,2024,10.1186/s12964-024-01868-4,https://pubmed.ncbi.nlm.nih.gov/39415254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,42449899,Machine Learning-Based Prediction of Masaoka-Koga Stage and WHO Histological Risk Group in Thymic Epithelial Tumors Using Biomarker Combinations.,2026,10.3390/diagnostics16132118,https://pubmed.ncbi.nlm.nih.gov/42449899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,40489480,Hepatic transcriptome profiling unveils candidate genes in cattle with liver abscesses under the influence of beef genetics in dairy cattle.,2025,10.1371/journal.pone.0324209,https://pubmed.ncbi.nlm.nih.gov/40489480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,41153973,Whole-Genome Resequencing Identifies Candidate Genes for Tail Fat Deposition in Sheep.,2025,10.3390/ani15203046,https://pubmed.ncbi.nlm.nih.gov/41153973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,42450718,Weighted Single-Step Genomic Evaluation of Body Structural Traits for Early Selection of Growth Performance in Thai Swamp Buffalo.,2026,10.3390/ani16132012,https://pubmed.ncbi.nlm.nih.gov/42450718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,37906960,Engineered Recombinant EGFP-Azurin Theranostic Nanosystem for Targeted Therapy of Prostate Cancer.,2023,10.1021/acs.molpharmaceut.3c00387,https://pubmed.ncbi.nlm.nih.gov/37906960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,41096466,Selection Signatures in the Genome of Dzhalgin Merino Sheep Breed.,2025,10.3390/ani15192871,https://pubmed.ncbi.nlm.nih.gov/41096466/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,38952552,"A pan-cancer analysis of EphA family gene expression and its association with prognosis, tumor microenvironment, and therapeutic targets.",2024,10.3389/fonc.2024.1378087,https://pubmed.ncbi.nlm.nih.gov/38952552/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,37855835,Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population.,2023,10.7554/elife.87569,https://pubmed.ncbi.nlm.nih.gov/37855835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,37542675,Molecular signature of excessive female aggression: study of stressed mice with genetic inactivation of neuronal serotonin synthesis.,2023,10.1007/s00702-023-02677-8,https://pubmed.ncbi.nlm.nih.gov/37542675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,38540412,Genome-Wide DNA Methylation Analysis and Functional Validation of Litter Size Traits in Jining Grey Goats.,2024,10.3390/genes15030353,https://pubmed.ncbi.nlm.nih.gov/38540412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,37868195,Time-course adaptive changes in hippocampal transcriptome and synaptic function induced by simulated microgravity associated with cognition.,2023,10.3389/fncel.2023.1275771,https://pubmed.ncbi.nlm.nih.gov/37868195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,31483918,Tyrosine kinase Eph receptor A6 sensitizes glioma-initiating cells towards bone morphogenetic protein-induced apoptosis.,2019,10.1111/cas.14187,https://pubmed.ncbi.nlm.nih.gov/31483918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,32344861,"Breakpoint Mapping of Symptomatic Balanced Translocations Links the EPHA6, KLF13 and UBR3 Genes to Novel Disease Phenotype.",2020,10.3390/jcm9051245,https://pubmed.ncbi.nlm.nih.gov/32344861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,35626181,"EPHA2, EPHA4, and EPHA6 Expression in Uveal Melanomas: Searching for the Culprits of Neoplasia.",2022,10.3390/diagnostics12051025,https://pubmed.ncbi.nlm.nih.gov/35626181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,32764470,Circulating Long Noncoding RNA LNC-EPHA6 Associates with Acute Rejection after Kidney Transplantation.,2020,10.3390/ijms21165616,https://pubmed.ncbi.nlm.nih.gov/32764470/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,29552165,Erythropoietin-producing hepatocellular A6 overexpression is a novel biomarker of poor prognosis in patients with breast cancer.,2018,10.3892/ol.2018.7919,https://pubmed.ncbi.nlm.nih.gov/29552165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,39034804,[Clinicopathological analysis of gastric adenocarcinoma with elevated serum alpha-fetoprotein and enteroblastic differentiation].,2024,10.3760/cma.j.cn112152-20230710-00004,https://pubmed.ncbi.nlm.nih.gov/39034804/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,35892315,Pharmacogenetics of taxane-induced neurotoxicity in breast cancer: Systematic review and meta-analysis.,2022,10.1111/cts.13370,https://pubmed.ncbi.nlm.nih.gov/35892315/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,36549768,Association of Genetic Polymorphism with Taxane-induced Peripheral Neuropathy: Sub-analysis of a Randomized Phase II Study to Determine the Optimal Dose of 3-week Cycle Nab-Paclitaxel in Metastatic Breast Cancer Patients.,2022,10.18926/amo/64116,https://pubmed.ncbi.nlm.nih.gov/36549768/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,34943502,Ephrin Receptors (Ephs) Expression in Thymic Epithelial Tumors: Prognostic Implications and Future Therapeutic Approaches.,2021,10.3390/diagnostics11122265,https://pubmed.ncbi.nlm.nih.gov/34943502/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,36598552,The impact of single nucleotide polymorphisms on return-to-work after taxane-based chemotherapy in breast cancer.,2023,10.1007/s00280-022-04499-z,https://pubmed.ncbi.nlm.nih.gov/36598552/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,32843430,Functional genomic analysis identifies drug targetable pathways in invasive and metastatic cutaneous squamous cell carcinoma.,2020,10.1101/mcs.a005439,https://pubmed.ncbi.nlm.nih.gov/32843430/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,33833937,Identification of a 5-Gene-Based Scoring System by WGCNA and LASSO to Predict Prognosis for Rectal Cancer Patients.,2021,10.1155/2021/6697407,https://pubmed.ncbi.nlm.nih.gov/33833937/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,36053834,ROS1 genomic rearrangements are rare actionable drivers in microsatellite stable colorectal cancer.,2022,10.1002/ijc.34257,https://pubmed.ncbi.nlm.nih.gov/36053834/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,31823378,Genetic variation in EPHA contributes to sensitivity to paclitaxel-induced peripheral neuropathy.,2020,10.1111/bcp.14192,https://pubmed.ncbi.nlm.nih.gov/31823378/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,31023863,"A Pilot, Phase II, Randomized, Open-Label Clinical Trial Comparing the Neurotoxicity of Three Dose Regimens of Nab-Paclitaxel to That of Solvent-Based Paclitaxel as the First-Line Treatment for Patients with Human Epidermal Growth Factor Receptor Type 2-Negative Metastatic Breast Cancer.",2019,10.1634/theoncologist.2017-0664,https://pubmed.ncbi.nlm.nih.gov/31023863/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,30524961,Clinical and Genetic Factors to Inform Reducing Colorectal Cancer Disparitites in African Americans.,2018,10.3389/fonc.2018.00531,https://pubmed.ncbi.nlm.nih.gov/30524961/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,34196487,Candidate l-methionine target piRNA regulatory networks analysis response to cocaine-conditioned place preference in mice.,2021,10.1002/brb3.2272,https://pubmed.ncbi.nlm.nih.gov/34196487/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,27582484,Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy.,2017,10.1158/1078-0432.ccr-16-0694,https://pubmed.ncbi.nlm.nih.gov/27582484/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,26585358,Genetic polymorphisms and paclitaxel- or docetaxel-induced toxicities: A systematic review.,2015,10.1016/j.ctrv.2015.10.010,https://pubmed.ncbi.nlm.nih.gov/26585358/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,25583493,Novel recurrently mutated genes in African American colon cancers.,2015,10.1073/pnas.1417064112,https://pubmed.ncbi.nlm.nih.gov/25583493/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA6,ENSG00000080224,Unsafe,14726470,Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers.,2004,10.1373/clinchem.2003.026849,https://pubmed.ncbi.nlm.nih.gov/14726470/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,41516312,Ephrin Receptors and Ephrin Ligands in Uveal Melanoma: A Big Data Analysis Using Web Resources.,2025,10.3390/ijms27010442,https://pubmed.ncbi.nlm.nih.gov/41516312/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,42589701,SASH1 as a Context-Dependent Multi-Docking Scaffold Linking Receptor Signaling to Cytoskeletal Dynamics.,2026,10.3390/ijms27157052,https://pubmed.ncbi.nlm.nih.gov/42589701/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,39358131,"Effect of body mass index on semen quality, sperm chromatin integrity and sperm DNA methylation.",2024,10.1016/j.orcp.2024.09.276,https://pubmed.ncbi.nlm.nih.gov/39358131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,40426233,Ephrin-A5 or EphA7 stimulation is anti-proliferative for human rhabdomyosarcoma in vitro.,2025,10.1186/s13395-025-00384-4,https://pubmed.ncbi.nlm.nih.gov/40426233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,40240402,Association of heightened host and tumor immunity with prolonged duration of response to checkpoint inhibition across solid tumors.,2025,10.1038/s41598-025-96925-4,https://pubmed.ncbi.nlm.nih.gov/40240402/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,39755699,Delivery of Prime editing in human stem cells using pseudoviral NanoScribes particles.,2025,10.1038/s41467-024-55604-0,https://pubmed.ncbi.nlm.nih.gov/39755699/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,37619706,SASH1: A Novel Eph Receptor Partner and Insights into SAM-SAM Interactions.,2023,10.1016/j.jmb.2023.168243,https://pubmed.ncbi.nlm.nih.gov/37619706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,41452581,"The secondary bile acid, lithocholic acid, inhibits cystic fibrosis transmembrane conductance regulator expression and activity in colonic epithelial cells.",2026,10.1152/ajpgi.00341.2025,https://pubmed.ncbi.nlm.nih.gov/41452581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,36717102,Normal muscle fiber type distribution is recapitulated in aged ephrin-A3-/- mice that previously lacked most slow myofibers.,2023,10.1152/ajpcell.00519.2022,https://pubmed.ncbi.nlm.nih.gov/36717102/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,38952552,"A pan-cancer analysis of EphA family gene expression and its association with prognosis, tumor microenvironment, and therapeutic targets.",2024,10.3389/fonc.2024.1378087,https://pubmed.ncbi.nlm.nih.gov/38952552/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,39436282,Enrichment of Allelic Editing Outcomes by Prime Editing in Induced Pluripotent Stem Cells.,2024,10.1089/crispr.2024.0028,https://pubmed.ncbi.nlm.nih.gov/39436282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,34278497,EphA8 inhibits cell apoptosis via AKT signaling and is associated with poor prognosis in breast cancer.,2021,10.3892/or.2021.8134,https://pubmed.ncbi.nlm.nih.gov/34278497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,34949656,Artesunate-induced Cellular Effects Are Mediated by Specific EPH Receptors and Ephrin Ligands in Breast Carcinoma Cells.,2022,10.21873/cgp.20300,https://pubmed.ncbi.nlm.nih.gov/34949656/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,33099474,Stem-like Cells from Invasive Breast Carcinoma Cell Line MDA-MB-231 Express a Distinct Set of Eph Receptors and Ephrin Ligands.,2020,10.21873/cgp.20227,https://pubmed.ncbi.nlm.nih.gov/33099474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,34875545,Generation of AAVS1 integrated doxycycline-inducible CRISPR-Prime Editor human induced pluripotent stem cell line.,2021,10.1016/j.scr.2021.102610,https://pubmed.ncbi.nlm.nih.gov/34875545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,33530159,Bone marrow stromal cells derived exosomal miR-10a and miR-16 may be involved in progression of patients with multiple myeloma by regulating EPHA8 or IGF1R/CCND1.,2021,10.1097/md.0000000000023447,https://pubmed.ncbi.nlm.nih.gov/33530159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,33233470,Emerging Kinase Therapeutic Targets in Pancreatic Ductal Adenocarcinoma and Pancreatic Cancer Desmoplasia.,2020,10.3390/ijms21228823,https://pubmed.ncbi.nlm.nih.gov/33233470/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,36744178,Identification of miRNA-mediated gene regulatory networks in L-methionine exposure counteracts cocaine-conditioned place preference in mice.,2022,10.3389/fgene.2022.1076156,https://pubmed.ncbi.nlm.nih.gov/36744178/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,30300334,EphA8 is a Prognostic Factor for Oral Tongue Squamous Cell Carcinoma.,2018,10.12659/msm.910909,https://pubmed.ncbi.nlm.nih.gov/30300334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,33713695,Comprehensive genetic profiling of six pulmonary nuclear protein in testis carcinomas with a novel micropapillary histological subtype in two cases.,2021,10.1016/j.humpath.2021.02.004,https://pubmed.ncbi.nlm.nih.gov/33713695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,37444464,Identification of Genetic Risk Factors for Keratinocyte Cancer in Immunosuppressed Solid Organ Transplant Recipients: A Case-Control Study.,2023,10.3390/cancers15133354,https://pubmed.ncbi.nlm.nih.gov/37444464/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,36598552,The impact of single nucleotide polymorphisms on return-to-work after taxane-based chemotherapy in breast cancer.,2023,10.1007/s00280-022-04499-z,https://pubmed.ncbi.nlm.nih.gov/36598552/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,26989075,EphA8 is a prognostic marker for epithelial ovarian cancer.,2016,10.18632/oncotarget.8018,https://pubmed.ncbi.nlm.nih.gov/26989075/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,35088383,Transcriptome-guided resolution of tumor microenvironment interactions in pheochromocytoma and paraganglioma subtypes.,2022,10.1007/s40618-021-01729-8,https://pubmed.ncbi.nlm.nih.gov/35088383/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,31823378,Genetic variation in EPHA contributes to sensitivity to paclitaxel-induced peripheral neuropathy.,2020,10.1111/bcp.14192,https://pubmed.ncbi.nlm.nih.gov/31823378/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,31023863,"A Pilot, Phase II, Randomized, Open-Label Clinical Trial Comparing the Neurotoxicity of Three Dose Regimens of Nab-Paclitaxel to That of Solvent-Based Paclitaxel as the First-Line Treatment for Patients with Human Epidermal Growth Factor Receptor Type 2-Negative Metastatic Breast Cancer.",2019,10.1634/theoncologist.2017-0664,https://pubmed.ncbi.nlm.nih.gov/31023863/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,33213062,Kinome Array Profiling of Patient-Derived Pancreatic Ductal Adenocarcinoma Identifies Differentially Active Protein Tyrosine Kinases.,2020,10.3390/ijms21228679,https://pubmed.ncbi.nlm.nih.gov/33213062/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,27928465,Gene expression and pathway analysis of CTNNB1 in cancer and stem cells.,2016,10.4252/wjsc.v8.i11.384,https://pubmed.ncbi.nlm.nih.gov/27928465/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,32856797,"Behavioral changes and gene profile alterations after chronic 1,950-MHz radiofrequency exposure: An observation in C57BL/6 mice.",2020,10.1002/brb3.1815,https://pubmed.ncbi.nlm.nih.gov/32856797/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,32060095,"The Shb scaffold binds the Nck adaptor protein, p120 RasGAP, and Chimaerins and thereby facilitates heterotypic cell segregation by the receptor EphB2.",2020,10.1074/jbc.ra119.009276,https://pubmed.ncbi.nlm.nih.gov/32060095/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,27582484,Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy.,2017,10.1158/1078-0432.ccr-16-0694,https://pubmed.ncbi.nlm.nih.gov/27582484/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,25855521,EphA receptors form a complex with caspase-8 to induce apoptotic cell death.,2015,10.14348/molcells.2015.2279,https://pubmed.ncbi.nlm.nih.gov/25855521/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHA8,ENSG00000070886,Unsafe,14726470,Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers.,2004,10.1373/clinchem.2003.026849,https://pubmed.ncbi.nlm.nih.gov/14726470/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,42406553,EphB1-Mediated Transient Blood-Brain Barrier Opening Facilitates a Ferritin-Based Nanotherapeutic for Alzheimer's Disease.,2026,10.1002/advs.76480,https://pubmed.ncbi.nlm.nih.gov/42406553/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,42817043,EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2-Mediated µ-Opioid Receptor Internalization.,2026,10.1002/advs.78099,https://pubmed.ncbi.nlm.nih.gov/42817043/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,42831919,Transcriptional activation of EPHB1 by SOX2 promotes epithelial-mesenchymal transition and metastasis in esophageal squamous cell carcinoma.,2026,10.1007/s10585-026-10434-w,https://pubmed.ncbi.nlm.nih.gov/42831919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,41200151,Beyond cell-cell contact: therapeutic potential of Eph signaling in central nervous system tumors.,2025,10.3389/fnmol.2025.1658651,https://pubmed.ncbi.nlm.nih.gov/41200151/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,41348875,EphB1-NR2B receptor signaling in glutamatergic neurons of the ventroposteromedial thalamic nucleus regulates emergence from anesthesia.,2025,10.1126/sciadv.adw7972,https://pubmed.ncbi.nlm.nih.gov/41348875/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,42181748,Autoencoder Denoising for Network-Based Spatial Transcriptomics Data with Applications for Cell Signaling Estimation.,2026,10.1007/978-3-032-16719-4_16,https://pubmed.ncbi.nlm.nih.gov/42181748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,42523149,Novel blood lncRNA biomarkers associated with clinical severity and specific cognitive dimensions in Alzheimer's disease.,2026,10.1177/13872877261470430,https://pubmed.ncbi.nlm.nih.gov/42523149/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,40207393,Disruption of Ephb1 causes reduced hypothalamic CRH and TRH expression and obesity in mice.,2025,10.1002/oby.24275,https://pubmed.ncbi.nlm.nih.gov/40207393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,40790791,"Tissue microarray and liquid biopsy approaches identify EphB3, cMet, and miR-3168 as biomarkers of colorectal cancer.",2025,10.1080/15384101.2025.2539651,https://pubmed.ncbi.nlm.nih.gov/40790791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,42627699,Circulating Ephrin-Eph Signaling Reflects Interstitial Fibrosis and Tubular Atrophy in Diabetic Kidney Disease.,2026,10.2215/cjn.0000001191,https://pubmed.ncbi.nlm.nih.gov/42627699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,40548257,EPHB1 Protein Promoted the Progression of Prostate Adenocarcinoma Through Phosphorylating GSK3B and Activating EPHB1-GSK3B-SMAD3 Pathway.,2025,10.1155/humu/4961883,https://pubmed.ncbi.nlm.nih.gov/40548257/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,42230518,Gliosarcoma of the craniovertebral junction with loss of H3K27me3: a case report with molecular profiling.,2026,10.1007/s10014-026-00543-5,https://pubmed.ncbi.nlm.nih.gov/42230518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,42196284,A Synaptogenesis-Associated Histomorphologic Signature from H&amp;E Whole-Slide Images Predicts Glioma Prognosis and Identifies &lt;i&gt;EFNB2&lt;/i&gt;-Positive Malignant Cells as a Candidate Neuro-Glioma Communication Hub.,2026,10.3390/ijms27104300,https://pubmed.ncbi.nlm.nih.gov/42196284/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,39648610,Reciprocal tumor-platelet interaction through the EPHB1-EFNB1 axis in the liver metastatic niche promotes metastatic tumor outgrowth in pancreatic ductal adenocarcinoma.,2025,10.1002/cac2.12637,https://pubmed.ncbi.nlm.nih.gov/39648610/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,40510773,Cell signaling characterization for spatial transcriptomics (ST) data using network analysis.,2025,10.1007/978-3-031-82435-7_32,https://pubmed.ncbi.nlm.nih.gov/40510773/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,38345254,EphB1 controls long-range cortical axon guidance through a cell non-autonomous role in GABAergic cells.,2024,10.1242/dev.201439,https://pubmed.ncbi.nlm.nih.gov/38345254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,40769385,Discovery of pan-EphB tyrosine kinase inhibitor for metabolic syndrome sparing EphB3 signaling in mice.,2025,10.1016/j.phrs.2025.107900,https://pubmed.ncbi.nlm.nih.gov/40769385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,40388884,Calcifying pseudoneoplasm of the neuraxis progressing to G5/PDGFRA subgroup glioblastoma in a United States Army veteran with a history of head trauma and germline POT1 and EPHB2 mutations: illustrative case.,2025,10.3171/case25152,https://pubmed.ncbi.nlm.nih.gov/40388884/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,40100272,Mistargeted retinal axons induce a synaptically independent subcircuit in the visual thalamus of albino mice.,2025,10.7554/elife.100990,https://pubmed.ncbi.nlm.nih.gov/40100272/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,42481375,"Genetic architecture of a Circadian Imbalance Index: genome-wide association, phenome-wide association, and Mendelian randomisation analyses.",2026,10.1016/j.ebiom.2026.106380,https://pubmed.ncbi.nlm.nih.gov/42481375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,40145984,Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development.,2025,10.1158/2326-6066.cir-24-0737,https://pubmed.ncbi.nlm.nih.gov/40145984/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,41645616,Identification of GAPDH as an Allergen in Allium Mongolicum Regel and Its Pro-Inflammatory Effects on respiratory and Intestinal Epithelia.,2026,10.1002/mnfr.70405,https://pubmed.ncbi.nlm.nih.gov/41645616/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,41482347,Mutational Spectrum of T-Cell Large Granular Lymphocytic Leukemia: Insights From the AACR Project GENIE Consortium.,2026,10.21873/cgp.20566,https://pubmed.ncbi.nlm.nih.gov/41482347/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,39011998,"Fusion Genes Landscape of Lung Cancer Patients From Inner Mongolia, China.",2024,10.1002/gcc.23258,https://pubmed.ncbi.nlm.nih.gov/39011998/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,37527777,Colorectal cancer-associated mutations impair EphB1 kinase function.,2023,10.1016/j.jbc.2023.105115,https://pubmed.ncbi.nlm.nih.gov/37527777/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,39555056,Somatic mutational landscape reveals mutational signatures and significantly mutated genes of cancer immunotherapeutic outcome and sex disparities.,2024,10.3389/fimmu.2024.1423796,https://pubmed.ncbi.nlm.nih.gov/39555056/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,38231476,Inhibition of Ephrin B2 Reverse Signaling Abolishes Multiple Myeloma Pathogenesis.,2024,10.1158/0008-5472.can-23-1950,https://pubmed.ncbi.nlm.nih.gov/38231476/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,39992429,The mutational landscape and its longitudinal dynamics in relapsed and refractory classic Hodgkin lymphoma.,2025,10.1007/s00277-025-06274-5,https://pubmed.ncbi.nlm.nih.gov/39992429/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,34094683,"Genetic variants of DOCK2, EPHB1 and VAV2 in the natural killer cell-related pathway are associated with non-small cell lung cancer survival.",2021,,https://pubmed.ncbi.nlm.nih.gov/34094683/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,41096387,Multi-Omics Analysis Reveals Concentrate Supplementation Alleviates Body Weight Loss by Regulating Rumen Function in Lactating Tibetan Sheep During the Cold Season.,2025,10.3390/ani15192791,https://pubmed.ncbi.nlm.nih.gov/41096387/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,33627480,Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.,2021,10.1073/pnas.2016265118,https://pubmed.ncbi.nlm.nih.gov/33627480/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPHB1,ENSG00000154928,Unsafe,39034804,[Clinicopathological analysis of gastric adenocarcinoma with elevated serum alpha-fetoprotein and enteroblastic differentiation].,2024,10.3760/cma.j.cn112152-20230710-00004,https://pubmed.ncbi.nlm.nih.gov/39034804/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,41625981,Multigenerational effects of uranium exposure reveal stronger testicular dysregulation in the second generation.,2026,10.1016/j.crtox.2025.100279,https://pubmed.ncbi.nlm.nih.gov/41625981/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,39665756,Large-scale CRISPR/Cas9 deletions within the WFDC gene cluster uncover gene functionality and critical roles in mammalian reproduction.,2024,10.1073/pnas.2413195121,https://pubmed.ncbi.nlm.nih.gov/39665756/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,37658081,Interactions of the male contraceptive target EPPIN with semenogelin-1 and small organic ligands.,2023,10.1038/s41598-023-41365-1,https://pubmed.ncbi.nlm.nih.gov/37658081/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,30324162,The Expressional Pattern of Epididymal Protease Inhibitor (EPPIN) in the Male Syrian Hamsters.,2018,10.12717/dr.2018.22.3.253,https://pubmed.ncbi.nlm.nih.gov/30324162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,32044375,Epididymal protease inhibitor (EPPIN) is a protein hub for seminal vesicle-secreted protein SVS2 binding in mouse spermatozoa.,2020,10.1016/j.mce.2020.110754,https://pubmed.ncbi.nlm.nih.gov/32044375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,33607572,siRNA-mediated Eppin testicular silencing causes changes in sperm motility and calcium currents in mice.,2021,10.1016/j.repbio.2021.100485,https://pubmed.ncbi.nlm.nih.gov/33607572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,19801999,Localization of epididymal protease inhibitor in adult rat and its transcription profile in testis during postnatal development.,2009,10.1038/aja.2009.66,https://pubmed.ncbi.nlm.nih.gov/19801999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,23070980,Epididymal protease inhibitor (EPPIN) is differentially expressed in the male rat reproductive tract and immunolocalized in maturing spermatozoa.,2012,10.1002/mrd.22119,https://pubmed.ncbi.nlm.nih.gov/23070980/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,29672554,"Inhibition of sperm motility in male macaques with EP055, a potential non-hormonal male contraceptive.",2018,10.1371/journal.pone.0195953,https://pubmed.ncbi.nlm.nih.gov/29672554/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,25289806,Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret.,2015,10.1016/j.mce.2014.09.029,https://pubmed.ncbi.nlm.nih.gov/25289806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,26593445,Non-hormonal male contraception: A review and development of an Eppin based contraceptive.,2016,10.1016/j.pharmthera.2015.11.004,https://pubmed.ncbi.nlm.nih.gov/26593445/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,21461566,Distribution of Eppin in mouse and human testis.,2011,10.3892/mmr.2010.403,https://pubmed.ncbi.nlm.nih.gov/21461566/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,21936831,Functional studies of eppin.,2011,10.1042/bst0391447,https://pubmed.ncbi.nlm.nih.gov/21936831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,28705940,Characterisation of eppin function: expression and activity in the lung.,2017,10.1183/13993003.01937-2016,https://pubmed.ncbi.nlm.nih.gov/28705940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,33931201,Emerging approaches to male contraception.,2021,10.1016/j.fertnstert.2021.03.047,https://pubmed.ncbi.nlm.nih.gov/33931201/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,21441428,Epididymal protein targets: a brief history of the development of epididymal protease inhibitor as a contraceptive.,2011,10.2164/jandrol.110.012781,https://pubmed.ncbi.nlm.nih.gov/21441428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,24358212,Correlation of epididymal protease inhibitor and fibronectin in human semen.,2013,10.1371/journal.pone.0082600,https://pubmed.ncbi.nlm.nih.gov/24358212/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,25424926,Nasal immunization using a mimovirus vaccine based on the Eppin B-cell epitope induced suppressed fertility in mice.,2014,10.4161/hv.29200,https://pubmed.ncbi.nlm.nih.gov/25424926/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,21892195,Preparation and immunogenicity of tag-free recombinant human eppin.,2011,10.1038/aja.2011.89,https://pubmed.ncbi.nlm.nih.gov/21892195/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,25673547,Development of antifertility vaccine using sperm specific proteins.,2014,,https://pubmed.ncbi.nlm.nih.gov/25673547/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,40425996,"First-in-line subcutaneous injectable for reversible, non-hormonal male contraception.",2026,10.1007/s13346-025-01871-3,https://pubmed.ncbi.nlm.nih.gov/40425996/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,37141450,Advances in non-hormonal male contraception targeting sperm motility.,2023,10.1093/humupd/dmad008,https://pubmed.ncbi.nlm.nih.gov/37141450/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,21908656,Induction of specific immune response and suppression of fertility by B-cell-epitope-based mimovirus vaccine.,2011,10.1530/rep-11-0161,https://pubmed.ncbi.nlm.nih.gov/21908656/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,34804955,"Gastrointestinal Goblet Cell Adenocarcinomas Harbor Distinctive Clinicopathological, Immune, and Genomic Landscape.",2021,10.3389/fonc.2021.758643,https://pubmed.ncbi.nlm.nih.gov/34804955/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,20005859,Screening and identification of dominant functional fragments of human epididymal protease inhibitor.,2010,10.1016/j.vaccine.2009.11.080,https://pubmed.ncbi.nlm.nih.gov/20005859/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,21817855,A highly specific antibody response after protein prime-peptide boost immunization with Eppin/B-cell epitope in mice.,2011,10.4161/hv.7.8.16279,https://pubmed.ncbi.nlm.nih.gov/21817855/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,19041353,Protein prime-peptide boost as a new strategy induced an Eppin dominant B-cell epitope specific immune response and suppressed fertility.,2009,10.1016/j.vaccine.2008.11.025,https://pubmed.ncbi.nlm.nih.gov/19041353/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,30602479,Male Contraceptive Development: Update on Novel Hormonal and Nonhormonal Methods.,2019,10.1373/clinchem.2018.295089,https://pubmed.ncbi.nlm.nih.gov/30602479/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,17345778,[Advances in the studies of epididymal protease inhibitor--Eppin].,2007,,https://pubmed.ncbi.nlm.nih.gov/17345778/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,26469117,Brdt Bromodomains Inhibitors and Other Modern Means of Male Contraception.,2015,10.17219/acem/33827,https://pubmed.ncbi.nlm.nih.gov/26469117/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,16333968,[Advances in the study of epididymal protease inhibitor].,2005,,https://pubmed.ncbi.nlm.nih.gov/16333968/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EPPIN,ENSG00000101448,Unsafe,11404006,Cloning and sequencing of human Eppin: a novel family of protease inhibitors expressed in the epididymis and testis.,2001,10.1016/s0378-1119(01)00462-0,https://pubmed.ncbi.nlm.nih.gov/11404006/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,42459306,"ERCC6L in human cancers: oncogenic functions, molecular mechanisms, and clinical implications as a prognostic biomarker and therapeutic target.",2026,10.3389/fonc.2026.1812829,https://pubmed.ncbi.nlm.nih.gov/42459306/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,41981724,PICH facilitates iPSC reprogramming by alleviating genomic instability induced by DNA replication stress.,2026,10.1111/febs.70550,https://pubmed.ncbi.nlm.nih.gov/41981724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,42063149,ERCC6L drives lung adenocarcinoma metastasis: a PJA2/p53 ubiquitination-dependent mechanism.,2026,10.1186/s12931-026-03692-5,https://pubmed.ncbi.nlm.nih.gov/42063149/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,42847039,Primary Intraosseous Cavernous Hemangioma of the Petrous Bone Involving the Jugular Fossa Mimicking a Jugular Paraganglioma: A Radiologic-Pathologic Correlation and Review of Relevant Literature.,2026,10.7759/cureus.115906,https://pubmed.ncbi.nlm.nih.gov/42847039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,41564924,ERCC6L promotes cutaneous melanoma progression via PLK1-mediated aerobic glycolysis: Mechanisms and therapeutic implications.,2026,10.1016/j.lfs.2026.124216,https://pubmed.ncbi.nlm.nih.gov/41564924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,41467366,Pediatric Intracerebral Hemorrhage Management-Consensus Statement of the International Pediatric Stroke Organization-Part 1: Acute Phase and Workup.,2026,10.1161/jaha.124.039594,https://pubmed.ncbi.nlm.nih.gov/41467366/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,40691138,ERCC6L-mediated stabilization of HIF-1α enhances glycolysis and stemness properties of lung adenocarcinoma cells.,2025,10.1038/s41419-025-07879-4,https://pubmed.ncbi.nlm.nih.gov/40691138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,42714618,Rapidly involuting congenital hemangioma of the suprasellar region.,2026,10.1007/s00247-026-06780-2,https://pubmed.ncbi.nlm.nih.gov/42714618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,39561207,RAD52 and ERCC6L/PICH have a compensatory relationship for genome stability in mitosis.,2024,10.1371/journal.pgen.1011479,https://pubmed.ncbi.nlm.nih.gov/39561207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,40672391,Prognostic and tumor microenvironmental features of gastric cancer revealed by macrophage polarization and protein lactylation-related genes.,2025,10.3389/fgene.2025.1541489,https://pubmed.ncbi.nlm.nih.gov/40672391/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,40442039,PICH deficiency attenuates the progression of lung adenocarcinoma and disrupts the DNA damage response.,2025,10.1002/ctm2.70349,https://pubmed.ncbi.nlm.nih.gov/40442039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,38253636,PICH deficiency limits the progression of MYC-induced B-cell lymphoma.,2024,10.1038/s41408-024-00979-y,https://pubmed.ncbi.nlm.nih.gov/38253636/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,39919802,PICH impacts the spindle assembly checkpoint via its DNA translocase and SUMO-interaction activities.,2025,10.26508/lsa.202403140,https://pubmed.ncbi.nlm.nih.gov/39919802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,41805126,Mitotic BLM functions are required to maintain genomic stability.,2026,10.1093/nar/gkag199,https://pubmed.ncbi.nlm.nih.gov/41805126/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,40469341,Primary intraosseous cavernous hemangioma of the clivus in a pediatric patient: A case report and review of the literature.,2025,10.25259/sni_1125_2024,https://pubmed.ncbi.nlm.nih.gov/40469341/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,41659917,Is early venous thromboembolism prophylaxis safe and effective in trauma patients requiring urgent neurosurgical interventions: analysis of the prospective multicenter CLOTT study.,2026,10.1136/tsaco-2025-001884,https://pubmed.ncbi.nlm.nih.gov/41659917/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,40983188,Evaluation of the association between sex-linked genes and treatment response in lung cancer.,2025,10.1016/j.radonc.2025.111159,https://pubmed.ncbi.nlm.nih.gov/40983188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,40621993,The impact of hemorrhage extension on external ventricular drain associated infections in patients with non-aneurysmal primary intracerebral and/or intraventricular hemorrhage.,2026,10.1080/01616412.2025.2529568,https://pubmed.ncbi.nlm.nih.gov/40621993/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,39704103,The interplay of the translocase activity and protein recruitment function of PICH in ultrafine anaphase bridge resolution and genomic stability.,2025,10.1093/nar/gkae1249,https://pubmed.ncbi.nlm.nih.gov/39704103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,36550435,A pan-cancer analysis of the oncogenic role of ERCC6L.,2022,10.1186/s12885-022-10452-3,https://pubmed.ncbi.nlm.nih.gov/36550435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,39988478,Characterization of Immune Landscape Based on Homologous Recombination Deficiency Associated Signatures and Identification of Knockdown of ERCC6L to Promote Radiosensitivity in Breast Cancer.,2025,10.1002/jgm.70012,https://pubmed.ncbi.nlm.nih.gov/39988478/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,40499517,An inside job-CHIP infiltrates and promotes cancer.,2025,10.1016/j.immuni.2025.05.014,https://pubmed.ncbi.nlm.nih.gov/40499517/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,38618713,Predicting Progression of Intracranial Hemorrhage in the Prehospital TXA for TBI Trial.,2024,10.1089/neu.2023.0626,https://pubmed.ncbi.nlm.nih.gov/38618713/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,39195326,Postoperative Acute Intracranial Hemorrhage and Venous Thromboembolism in Patients with Brain Metastases Receiving Acetylsalicylic Acid Perioperatively.,2024,10.3390/curroncol31080343,https://pubmed.ncbi.nlm.nih.gov/39195326/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,35285582,Identification of tumor antigens and immune subtypes of glioma for mRNA vaccine development.,2022,10.1002/cam4.4633,https://pubmed.ncbi.nlm.nih.gov/35285582/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,37854939,Pan-genomic comparison of a potential solvent-tolerant alkaline protease-producing Exiguobacterium sp. TBG-PICH-001 isolated from a marine habitat.,2023,10.1007/s13205-023-03796-5,https://pubmed.ncbi.nlm.nih.gov/37854939/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,38781120,Mitotic deacetylase complex (MiDAC) recognizes the HIV-1 core promoter to control activated viral gene expression.,2024,10.1371/journal.ppat.1011821,https://pubmed.ncbi.nlm.nih.gov/38781120/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,37936456,Systematic Analysis of Tumor Stem Cell-related Gene Characteristics to Predict the PD-L1 Immunotherapy and Prognosis of Gastric Cancer.,2024,10.2174/0109298673278775231101064235,https://pubmed.ncbi.nlm.nih.gov/37936456/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,38664976,Degradation-Based Protein Profiling: A Case Study of Celastrol.,2024,10.1002/advs.202308186,https://pubmed.ncbi.nlm.nih.gov/38664976/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,37314427,Early venous thromboembolism prophylaxis in patients with trauma intracranial hemorrhage: Analysis of the prospective multicenter Consortium of Leaders in Traumatic Thromboembolism study.,2023,10.1097/ta.0000000000004007,https://pubmed.ncbi.nlm.nih.gov/37314427/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,38947387,"Derived from fangchinoline, LYY-35 exhibits an inhibiting effect on human NSCLC cancer A549 cells.",2024,10.7150/jca.96582,https://pubmed.ncbi.nlm.nih.gov/38947387/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,38323183,Development and validation of a novel stemness-related prognostic model for neuroblastoma using integrated machine learning and bioinformatics analyses.,2024,10.21037/tp-23-582,https://pubmed.ncbi.nlm.nih.gov/38323183/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,36985652,New Protic Ionic Liquids as Potential Additives to Lubricate Si-Based MEMS/NEMS.,2023,10.3390/molecules28062678,https://pubmed.ncbi.nlm.nih.gov/36985652/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,31382848,Fibrinolytic Activation in Patients with Progressive Intracranial Hemorrhage after Traumatic Brain Injury.,2021,10.1089/neu.2018.6234,https://pubmed.ncbi.nlm.nih.gov/31382848/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC6L,ENSG00000186871,Unsafe,33656476,Incorporating Immunoproteins in the Development of Classification Models of Progression of Intracranial Hemorrhage After Traumatic Brain Injury.,2021,10.1097/htr.0000000000000654,https://pubmed.ncbi.nlm.nih.gov/33656476/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,42531030,AAV-mediated gene therapy demonstrates phenotypic rescue in a mouse model of Cockayne syndrome.,2026,10.1172/jci196689,https://pubmed.ncbi.nlm.nih.gov/42531030/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,41749901,Repurposing Alkylating Agents in Melanoma via ERCC8 Silencing: A Novel Therapeutic Strategy.,2026,10.3390/cancers18040647,https://pubmed.ncbi.nlm.nih.gov/41749901/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,40302207,Pleiotropic effects of MORC2 derive from its epigenetic signature.,2026,10.1093/brain/awaf159,https://pubmed.ncbi.nlm.nih.gov/40302207/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,41299792,Clinical and molecular genetic analysis of a Chinese patient with Cockayne syndrome caused by ERCC8 gene synonymous variant at splicing site and exon 1 deletion.,2025,10.1186/s13023-025-03808-y,https://pubmed.ncbi.nlm.nih.gov/41299792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,42137269,Design and initial characterization of a novel mini-promoter for gene therapies targeting the central nervous system.,2026,10.1016/j.omta.2026.201681,https://pubmed.ncbi.nlm.nih.gov/42137269/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,42807679,Clinical and genomic characterization of corpus callosum abnormalities (CCA) in 107 Tunisian patients using a stepwise diagnostic approach.,2026,10.3389/fgene.2026.1815268,https://pubmed.ncbi.nlm.nih.gov/42807679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,40842628,"Clinical and genetic analysis of &lt;i&gt;ERCC8&lt;/i&gt;-Related cockayne syndrome: hepatic dysfunction as a biomarker, anhidrosis as a rare feature, and rehabilitation outcomes for ankle contractures.",2025,10.3389/fgene.2025.1591551,https://pubmed.ncbi.nlm.nih.gov/40842628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,41459025,A Truncating Variant in the &lt;i&gt;ERCC6&lt;/i&gt; Gene With Three Different Phenotypes: Significant Effects of Modifier Genes.,2025,10.1155/genr/7396691,https://pubmed.ncbi.nlm.nih.gov/41459025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,39187681,Biallelic structural variants in three patients with ERCC8-related Cockayne syndrome and a potential pitfall of copy number variation analysis.,2024,10.1038/s41598-024-70831-7,https://pubmed.ncbi.nlm.nih.gov/39187681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,39621529,Homozygous Microdeletion Involving Exon 1 of ERCC8 and NDUFAF2 With Uniparental Isodisomy of Chromosome 5.,2024,10.1002/mgg3.70037,https://pubmed.ncbi.nlm.nih.gov/39621529/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,36231052,A Novel Missense Mutation in &lt;i&gt;ERCC8&lt;/i&gt; Co-Segregates with Cerebellar Ataxia in a Consanguineous Pakistani Family.,2022,10.3390/cells11193090,https://pubmed.ncbi.nlm.nih.gov/36231052/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,40144890,A rare variation of ERCC8 gene cause Cockayne syndrome in a Chinese family.,2025,10.3389/fgene.2025.1531832,https://pubmed.ncbi.nlm.nih.gov/40144890/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,39582530,Characterization of the function and clinical value of ERCC family genes in lung adenocarcinoma.,2024,10.3389/fonc.2024.1476100,https://pubmed.ncbi.nlm.nih.gov/39582530/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,39511141,A mild case of Cockayne syndrome with a novel start-loss variant of ERCC8.,2024,10.1038/s41439-024-00297-6,https://pubmed.ncbi.nlm.nih.gov/39511141/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,36454558,Insufficient Dose of ERCC8 Protein Caused by a Frameshift Mutation Is Associated With Keratoconus With Congenital Cataracts.,2022,10.1167/iovs.63.13.1,https://pubmed.ncbi.nlm.nih.gov/36454558/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,40076972,A Truncated Mutation of TP53 Promotes Chemoresistance in Tongue Squamous Cell Carcinoma.,2025,10.3390/ijms26052353,https://pubmed.ncbi.nlm.nih.gov/40076972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,40570619,"Altered pathways in Cockayne syndrome: Involvement of MAPK, PI3K-Akt, extracellular matrix, inflammation, and neuronal signaling.",2025,10.1016/j.dnarep.2025.103861,https://pubmed.ncbi.nlm.nih.gov/40570619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,38603937,Molecular genetic foundation of a sex-linked tailless trait in Hongshan chicken by whole genome data analysis.,2024,10.1016/j.psj.2024.103685,https://pubmed.ncbi.nlm.nih.gov/38603937/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,35748794,Cockayne syndrome without UV-sensitivity in Vietnamese siblings with novel ERCC8 variants.,2022,10.18632/aging.204139,https://pubmed.ncbi.nlm.nih.gov/35748794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,38855094,Lipidomic analysis of grain quality variation in high quality aromatic japonica rice.,2024,10.1016/j.fochx.2024.101473,https://pubmed.ncbi.nlm.nih.gov/38855094/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,42634649,Surgical correction of severe rigid equinovarus deformity in Cockayne syndrome: perioperative challenges and multidisciplinary management-a case report.,2026,10.1093/jscr/rjag732,https://pubmed.ncbi.nlm.nih.gov/42634649/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,40157541,Transcription blocking properties and transcription-coupled repair of N&lt;sup&gt;2&lt;/sup&gt;-alkylguanine adducts as a model for aldehyde-induced DNA damage.,2025,10.1016/j.jbc.2025.108459,https://pubmed.ncbi.nlm.nih.gov/40157541/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,33277540,Integrative genomic analysis implicates ERCC6 and its interaction with ERCC8 in susceptibility to breast cancer.,2020,10.1038/s41598-020-77037-7,https://pubmed.ncbi.nlm.nih.gov/33277540/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,37592445,Next-generation sequencing through multi-gene panel testing for the diagnosis of a Chinese patient with atypical Cockayne syndrome.,2023,10.1002/mgg3.2254,https://pubmed.ncbi.nlm.nih.gov/37592445/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,37684436,Exploration of Key Immune-Related Transcriptomes Associated with Doxorubicin-Induced Cardiotoxicity in Patients with Breast Cancer.,2023,10.1007/s12012-023-09806-5,https://pubmed.ncbi.nlm.nih.gov/37684436/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,36791574,The Spectrum of MORC2-Related Disorders: A Potential Link to Cockayne Syndrome.,2023,10.1016/j.pediatrneurol.2023.01.011,https://pubmed.ncbi.nlm.nih.gov/36791574/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,35041720,Integration of gene co-expression analysis and multi-class SVM specifies the functional players involved in determining the fate of HTLV-1 infection toward the development of cancer (ATLL) or neurological disorder (HAM/TSP).,2022,10.1371/journal.pone.0262739,https://pubmed.ncbi.nlm.nih.gov/35041720/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,34440306,Upregulation of 15 Antisense Long Non-Coding RNAs in Osteosarcoma.,2021,10.3390/genes12081132,https://pubmed.ncbi.nlm.nih.gov/34440306/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,35377194,Association of Glyphosate Exposure with Blood DNA Methylation in a Cross-Sectional Study of Postmenopausal Women.,2022,10.1289/ehp10174,https://pubmed.ncbi.nlm.nih.gov/35377194/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,27374179,Cumulative defects in DNA repair pathways drive the PARP inhibitor response in high-grade serous epithelial ovarian cancer cell lines.,2017,10.18632/oncotarget.10308,https://pubmed.ncbi.nlm.nih.gov/27374179/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,29262528,Overexpression of parkin rescues the defective mitochondrial phenotype and the increased apoptosis of Cockayne Syndrome A cells.,2017,10.18632/oncotarget.9913,https://pubmed.ncbi.nlm.nih.gov/29262528/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,23892139,Effects of bisphosphonate treatment on DNA methylation in osteonecrosis of the jaw.,2013,10.1016/j.mrgentox.2013.07.003,https://pubmed.ncbi.nlm.nih.gov/23892139/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERCC8,ENSG00000049167,Unsafe,8596535,Rodent complementation group 8 (ERCC8) corresponds to Cockayne syndrome complementation group A.,1996,10.1016/0921-8777(95)00046-1,https://pubmed.ncbi.nlm.nih.gov/8596535/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERICH2,ENSG00000204334,Unsafe,32561905,CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity.,2020,10.1093/biolre/ioaa084,https://pubmed.ncbi.nlm.nih.gov/32561905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,41854718,Proteomic analyses of human islets reveal potential markers of β cell dysfunction during prediabetes.,2026,10.1172/jci.insight.182135,https://pubmed.ncbi.nlm.nih.gov/41854718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,40264416,Single-cell transcriptomic data reveal the cellular heterogeneity of glutamine metabolism in gastric premalignant lesions and early gastric cancer.,2025,10.3724/abbs.2025061,https://pubmed.ncbi.nlm.nih.gov/40264416/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,41377444,Identification of potential molecular targets for thyroid cancer using multiple-omics analysis and machine learning.,2025,10.1097/ms9.0000000000004019,https://pubmed.ncbi.nlm.nih.gov/41377444/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,40257028,Identification and Validation of Amino Acid Metabolism-Related Biomarkers and Investigation of their Potential Mechanisms in Lung Adenocarcinoma.,2025,10.2174/0115665232364091250203090710,https://pubmed.ncbi.nlm.nih.gov/40257028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,35568702,Establishment of prognostic risk model and drug sensitivity based on prognostic related genes of esophageal cancer.,2022,10.1038/s41598-022-11760-1,https://pubmed.ncbi.nlm.nih.gov/35568702/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,36223009,Effects of oocyte vitrification on gene expression in the liver and kidney tissues of adult offspring.,2022,10.1007/s10815-022-02611-z,https://pubmed.ncbi.nlm.nih.gov/36223009/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,36846594,Validating expression of beta cell maturation-associated genes in human pancreas development.,2023,10.3389/fcell.2023.1103719,https://pubmed.ncbi.nlm.nih.gov/36846594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,36639413,Deficiency of transcription factor Nkx6.1 does not prevent insulin secretion in INS-1E cells.,2023,10.1038/s41598-023-27985-7,https://pubmed.ncbi.nlm.nih.gov/36639413/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,39029818,Comprehensive analysis of miRNAs-lncRNAs-mRNAs modules and ceRNA network in acute liver failure: Hsa-miR3175 and C-reactive protein determination.,2024,10.1016/j.ijbiomac.2024.133919,https://pubmed.ncbi.nlm.nih.gov/39029818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,37814076,Plasma cell signatures predict prognosis and treatment efficacy for lung adenocarcinoma.,2024,10.1007/s13402-023-00883-w,https://pubmed.ncbi.nlm.nih.gov/37814076/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,37314747,Single ethanol binge causes severe liver injury in mice fed Western diet.,2023,10.1097/hc9.0000000000000174,https://pubmed.ncbi.nlm.nih.gov/37314747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,36552760,SARS-CoV-2 Pattern Provides a New Scoring System and Predicts the Prognosis and Immune Therapeutic Response in Glioma.,2022,10.3390/cells11243997,https://pubmed.ncbi.nlm.nih.gov/36552760/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,36109769,Genetic regulation of RNA splicing in human pancreatic islets.,2022,10.1186/s13059-022-02757-0,https://pubmed.ncbi.nlm.nih.gov/36109769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,38967666,Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h.,2024,10.1007/s00125-024-06214-4,https://pubmed.ncbi.nlm.nih.gov/38967666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,36303784,Diagnostic AI Modeling and Pseudo Time Series Profiling of AD and PD Based on Individualized Serum Proteome Data.,2021,10.3389/fbinf.2021.764497,https://pubmed.ncbi.nlm.nih.gov/36303784/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,38238732,Proteomic associations with forced expiratory volume: a Mendelian randomisation study.,2024,10.1186/s12931-023-02587-z,https://pubmed.ncbi.nlm.nih.gov/38238732/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,28177904,Genome-scale analysis identifies GJB2 and ERO1LB as prognosis markers in patients with pancreatic cancer.,2017,10.18632/oncotarget.15068,https://pubmed.ncbi.nlm.nih.gov/28177904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,32021278,Transcriptome Analysis Reveals Key Genes and Pathways Associated with Metastasis in Breast Cancer.,2020,10.2147/ott.s226770,https://pubmed.ncbi.nlm.nih.gov/32021278/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,32235589,Uncovering Prognosis-Related Genes and Pathways by Multi-Omics Analysis in Lung Cancer.,2020,10.3390/biom10040524,https://pubmed.ncbi.nlm.nih.gov/32235589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,24997997,Proteomic analysis of solid pseudopapillary tumor of the pancreas reveals dysfunction of the endoplasmic reticulum protein processing pathway.,2014,10.1074/mcp.m114.038786,https://pubmed.ncbi.nlm.nih.gov/24997997/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,20308425,"ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis.",2010,10.1083/jcb.200911086,https://pubmed.ncbi.nlm.nih.gov/20308425/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,16012172,Tissue-specific expression and dimerization of the endoplasmic reticulum oxidoreductase Ero1beta.,2005,10.1074/jbc.m505023200,https://pubmed.ncbi.nlm.nih.gov/16012172/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERO1B,ENSG00000086619,Unsafe,10818100,"Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response.",2000,10.1074/jbc.m003061200,https://pubmed.ncbi.nlm.nih.gov/10818100/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,41749969,Circulating &lt;i&gt;ERVFRD-1&lt;/i&gt; and &lt;i&gt;MFSD2A&lt;/i&gt; Are Associated with Immunotherapy Response in Metastatic Clear Cell Renal Cell Carcinoma.,2026,10.3390/cancers18040716,https://pubmed.ncbi.nlm.nih.gov/41749969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,41346767,Prediction of microRNAs affecting the syncytin-1 (HERV-W) and syncytin-2 (HERV-FRD) genes regulation in endometriosis and miscarriage.,2026,10.22099/mbrc.2025.54457.2225,https://pubmed.ncbi.nlm.nih.gov/41346767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,37780849,Endogenous retrovirus group FRD member 1 is a potential biomarker for prognosis and immunotherapy for kidney renal clear cell carcinoma.,2023,10.3389/fcimb.2023.1252905,https://pubmed.ncbi.nlm.nih.gov/37780849/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,38408442,Human Endogenous Retroviruses in Breast Cancer: Altered Expression Pattern Implicates Divergent Roles in Carcinogenesis.,2024,10.1159/000538021,https://pubmed.ncbi.nlm.nih.gov/38408442/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,34811492,Transcript-targeted analysis reveals isoform alterations and double-hop fusions in breast cancer.,2021,10.1038/s42003-021-02833-4,https://pubmed.ncbi.nlm.nih.gov/34811492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,37385477,Effects of valproic acid on syncytialization in human placental trophoblast cell lines.,2023,10.1016/j.taap.2023.116611,https://pubmed.ncbi.nlm.nih.gov/37385477/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,38968109,TFEB safeguards trophoblast syncytialization in humans and mice.,2024,10.1073/pnas.2404062121,https://pubmed.ncbi.nlm.nih.gov/38968109/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,37800606,Impact of Metabolic Stress on BeWo Syncytiotrophoblast Function.,2023,10.1002/cbic.202300410,https://pubmed.ncbi.nlm.nih.gov/37800606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,38997889,Optimized CRISPR-based knockout in BeWo cells.,2025,10.1016/j.placenta.2024.07.005,https://pubmed.ncbi.nlm.nih.gov/38997889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,39290630,Effect of a FOXO1 inhibitor on trophoblast differentiation from human pluripotent stem cells and ERV-associated gene expression.,2024,10.1016/j.reth.2024.08.020,https://pubmed.ncbi.nlm.nih.gov/39290630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,35816776,Beyond fusion: A novel role for ERVW-1 in trophoblast proliferation and type I interferon receptor expression.,2022,10.1016/j.placenta.2022.06.012,https://pubmed.ncbi.nlm.nih.gov/35816776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,36711387,Association between night shift work and methylation of a subset of immune-related genes.,2022,10.3389/fpubh.2022.1083826,https://pubmed.ncbi.nlm.nih.gov/36711387/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,33504453,Syncytins expressed in human placental trophoblast.,2021,10.1016/j.placenta.2021.01.006,https://pubmed.ncbi.nlm.nih.gov/33504453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,36595448,Silver nanoparticles suppress forskolin-induced syncytialization in BeWo cells.,2022,10.1080/17435390.2022.2162994,https://pubmed.ncbi.nlm.nih.gov/36595448/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,31278978,Effects of Bisphenol A on endogenous retroviral envelopes expression and trophoblast fusion in BeWo cells.,2019,10.1016/j.reprotox.2019.07.001,https://pubmed.ncbi.nlm.nih.gov/31278978/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,21771862,"Epigenetic regulation of transcription and splicing of syncytins, fusogenic glycoproteins of retroviral origin.",2011,10.1093/nar/gkr562,https://pubmed.ncbi.nlm.nih.gov/21771862/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,32092105,Reactive oxygen species from mitochondria impacts trophoblast fusion and the production of endocrine hormones by syncytiotrophoblasts.,2020,10.1371/journal.pone.0229332,https://pubmed.ncbi.nlm.nih.gov/32092105/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,28302141,DNA hypomethylation and aberrant expression of the human endogenous retrovirus ERVWE1/syncytin-1 in seminomas.,2017,10.1186/s12977-017-0342-9,https://pubmed.ncbi.nlm.nih.gov/28302141/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,29237055,The epigenetic control of transposable elements and imprinted genes in newborns is affected by the mode of conception: ART versus spontaneous conception without underlying infertility.,2018,10.1093/humrep/dex366,https://pubmed.ncbi.nlm.nih.gov/29237055/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,26992684,Expression patterns of ERVWE1/Syncytin-1 and other placentally expressed human endogenous retroviruses along the malignant transformation process of hydatidiform moles.,2016,10.1016/j.placenta.2016.01.011,https://pubmed.ncbi.nlm.nih.gov/26992684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVFRD-1,ENSG00000244476,Unsafe,12970426,Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.,2003,10.1128/jvi.77.19.10414-10422.2003,https://pubmed.ncbi.nlm.nih.gov/12970426/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,42652124,"Differential Expression and Co-Variation of HERV-Associated Transcripts, IL-17 Cytokines, and NFκB in Paired Colorectal Cancer Tissues.",2026,10.3390/biomedicines14081741,https://pubmed.ncbi.nlm.nih.gov/42652124/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,42077749,Association Between the ERVW-1 Gene Polymorphism (rs4727276) and the Pathogenesis of Preeclampsia: A Case-Control Study in Women From Northeast Brazil.,2026,10.7759/cureus.106233,https://pubmed.ncbi.nlm.nih.gov/42077749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,41754588,ERVWE1 Impairs Mitochondrial Homeostasis and Promotes Neuronal Apoptosis via the miR-27b-3p/BNIP3 Axis in Schizophrenia.,2026,10.3390/v18020245,https://pubmed.ncbi.nlm.nih.gov/41754588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,42549210,Asthma reconsidered: a cumulative data perspective on airway smooth muscle.,2026,10.1183/23120541.00261-2026,https://pubmed.ncbi.nlm.nih.gov/42549210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,42798596,Alterations of placental HERV expression as a result of gestational COVID-19 disease.,2026,10.3389/fmicb.2026.1901506,https://pubmed.ncbi.nlm.nih.gov/42798596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,40419114,Human endogenous retrovirus W family envelope protein (ERVWE1) regulates macroautophagy activation and micromitophagy inhibition via NOXA1 in schizophrenia.,2025,10.1016/j.virs.2025.05.007,https://pubmed.ncbi.nlm.nih.gov/40419114/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,42826626,Impaired syncytin-1-CXCR4 crosstalk contributes to trophoblast migration defects in preeclampsia.,2026,10.1016/j.placenta.2026.09.019,https://pubmed.ncbi.nlm.nih.gov/42826626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,37690733,Ancient dormant virus remnant ERVW-1 drives ferroptosis via degradation of GPX4 and SLC3A2 in schizophrenia.,2024,10.1016/j.virs.2023.09.001,https://pubmed.ncbi.nlm.nih.gov/37690733/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,39543767,"Ancestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2.",2024,10.1186/s13578-024-01318-1,https://pubmed.ncbi.nlm.nih.gov/39543767/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,41346767,Prediction of microRNAs affecting the syncytin-1 (HERV-W) and syncytin-2 (HERV-FRD) genes regulation in endometriosis and miscarriage.,2026,10.22099/mbrc.2025.54457.2225,https://pubmed.ncbi.nlm.nih.gov/41346767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,39018608,"Lower ERVW-1 and higher VEGF, FLT-1 and HIF-1 gene expression in placentae of low birth babies from Indonesia.",2024,10.1016/j.placenta.2024.07.006,https://pubmed.ncbi.nlm.nih.gov/39018608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,37376599,ERVW-1 Activates ATF6-Mediated Unfolded Protein Response by Decreasing GANAB in Recent-Onset Schizophrenia.,2023,10.3390/v15061298,https://pubmed.ncbi.nlm.nih.gov/37376599/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,37990254,Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms.,2023,10.1186/s13578-023-01167-4,https://pubmed.ncbi.nlm.nih.gov/37990254/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,41240505,Adenosine promotes trophoblast proliferation without inducing differentiation or apoptosis.,2025,10.1016/j.placenta.2025.11.005,https://pubmed.ncbi.nlm.nih.gov/41240505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,42218517,Integrative single-cell and bulk transcriptomics define cell death patterns and ZDHHC22 in gastric cancer progression.,2026,10.1186/s12920-026-02405-7,https://pubmed.ncbi.nlm.nih.gov/42218517/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,38408442,Human Endogenous Retroviruses in Breast Cancer: Altered Expression Pattern Implicates Divergent Roles in Carcinogenesis.,2024,10.1159/000538021,https://pubmed.ncbi.nlm.nih.gov/38408442/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,38403160,"The impact of wound-healing assay, phorbol myristate acetate (PMA) stimulation and siRNA-mediated FURIN gene silencing on endogenous retroviral ERVW-1 expression level in U87-MG astrocytoma cells.",2024,10.1016/j.advms.2024.02.007,https://pubmed.ncbi.nlm.nih.gov/38403160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,36680208,ERVWE1 Reduces Hippocampal Neuron Density and Impairs Dendritic Spine Morphology through Inhibiting Wnt/JNK Non-Canonical Pathway via miR-141-3p in Schizophrenia.,2023,10.3390/v15010168,https://pubmed.ncbi.nlm.nih.gov/36680208/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,34638599,"Could the Human Endogenous Retrovirus-Derived Syncytialization Inhibitor, Suppressyn, Limit Heterotypic Cell Fusion Events in the Decidua?",2021,10.3390/ijms221910259,https://pubmed.ncbi.nlm.nih.gov/34638599/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,35816776,Beyond fusion: A novel role for ERVW-1 in trophoblast proliferation and type I interferon receptor expression.,2022,10.1016/j.placenta.2022.06.012,https://pubmed.ncbi.nlm.nih.gov/35816776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,37385477,Effects of valproic acid on syncytialization in human placental trophoblast cell lines.,2023,10.1016/j.taap.2023.116611,https://pubmed.ncbi.nlm.nih.gov/37385477/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,35134484,Effects of tumor necrosis factor on undifferentiated and syncytialized placental choriocarcinoma BeWo cells.,2022,10.1016/j.tiv.2022.105327,https://pubmed.ncbi.nlm.nih.gov/35134484/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,36769337,HERV-W ENV Induces Innate Immune Activation and Neuronal Apoptosis via linc01930/cGAS Axis in Recent-Onset Schizophrenia.,2023,10.3390/ijms24033000,https://pubmed.ncbi.nlm.nih.gov/36769337/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,34434177,An Ancestral Retrovirus Envelope Protein Regulates Persistent Gammaherpesvirus Lifecycles.,2021,10.3389/fmicb.2021.708404,https://pubmed.ncbi.nlm.nih.gov/34434177/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,31278978,Effects of Bisphenol A on endogenous retroviral envelopes expression and trophoblast fusion in BeWo cells.,2019,10.1016/j.reprotox.2019.07.001,https://pubmed.ncbi.nlm.nih.gov/31278978/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,33322628,The Relationship of the Mechanisms of the Pathogenesis of Multiple Sclerosis and the Expression of Endogenous Retroviruses.,2020,10.3390/biology9120464,https://pubmed.ncbi.nlm.nih.gov/33322628/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,36711387,Association between night shift work and methylation of a subset of immune-related genes.,2022,10.3389/fpubh.2022.1083826,https://pubmed.ncbi.nlm.nih.gov/36711387/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,32092105,Reactive oxygen species from mitochondria impacts trophoblast fusion and the production of endocrine hormones by syncytiotrophoblasts.,2020,10.1371/journal.pone.0229332,https://pubmed.ncbi.nlm.nih.gov/32092105/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,24186980,Cell fusion induced by ERVWE1 or measles virus causes cellular senescence.,2013,10.1101/gad.227512.113,https://pubmed.ncbi.nlm.nih.gov/24186980/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,24098463,Expression of human endogenous retrovirus-w including syncytin-1 in cutaneous T-cell lymphoma.,2013,10.1371/journal.pone.0076281,https://pubmed.ncbi.nlm.nih.gov/24098463/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,22238282,The molecular role of connexin 43 in human trophoblast cell fusion.,2012,10.1095/biolreprod.111.096925,https://pubmed.ncbi.nlm.nih.gov/22238282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,21771862,"Epigenetic regulation of transcription and splicing of syncytins, fusogenic glycoproteins of retroviral origin.",2011,10.1093/nar/gkr562,https://pubmed.ncbi.nlm.nih.gov/21771862/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,22131944,Human endogenous retroviruses in multiple sclerosis: potential for novel neuro-pharmacological research.,2011,10.2174/157015911795596568,https://pubmed.ncbi.nlm.nih.gov/22131944/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,32401642,Autophagy in the physiological endometrium and cancer.,2021,10.1080/15548627.2020.1752548,https://pubmed.ncbi.nlm.nih.gov/32401642/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,15507602,A retroviral promoter and a cellular enhancer define a bipartite element which controls env ERVWE1 placental expression.,2004,10.1128/jvi.78.22.12157-12168.2004,https://pubmed.ncbi.nlm.nih.gov/15507602/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,15452578,Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination.,2004,10.1038/nn1319,https://pubmed.ncbi.nlm.nih.gov/15452578/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,12970426,Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.,2003,10.1128/jvi.77.19.10414-10422.2003,https://pubmed.ncbi.nlm.nih.gov/12970426/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,10708449,An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor.,2000,10.1128/jvi.74.7.3321-3329.2000,https://pubmed.ncbi.nlm.nih.gov/10708449/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ERVW-1,ENSG00000242950,Unsafe,10693809,Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis.,2000,10.1038/35001608,https://pubmed.ncbi.nlm.nih.gov/10693809/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,42677418,[Functional study of &lt;i&gt;Esco2&lt;/i&gt; in promoting proliferation and survival of acute myeloid leukemia cells].,2026,10.13294/j.aps.2026.0055,https://pubmed.ncbi.nlm.nih.gov/42677418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,42277036,Targeting SMC3 deacetylation synergizes with XPO1 inhibition to reprogram the epigenetic landscape and suppress NPM1-mutated acute myeloid leukemia.,2026,10.1038/s41467-026-74343-y,https://pubmed.ncbi.nlm.nih.gov/42277036/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,42305461,Carcinogenic role of ESCO2 in cholangiocarcinoma: integration of bioinformatics analysis and experimental validation.,2026,10.21037/tcr-2025-1-2695,https://pubmed.ncbi.nlm.nih.gov/42305461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,41053890,The expression of establishment of cohesion 1 homolog 2 (ESCO2) in tumor cells and its research progress as a therapeutic target.,2025,10.1186/s40001-025-03164-4,https://pubmed.ncbi.nlm.nih.gov/41053890/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,40657363,ESCO2 promotes the proliferation of hepatocellular carcinoma through the PI3K/AKT/ mTOR signaling pathway.,2025,10.7150/jca.112087,https://pubmed.ncbi.nlm.nih.gov/40657363/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,40708936,ESCO2 inhibition induces cell cycle arrest and apoptosis in breast cancer via the P53-CDK1 axis and the BAX/Bcl2/caspase signaling cascade.,2025,10.3389/fonc.2025.1585945,https://pubmed.ncbi.nlm.nih.gov/40708936/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,42438665,Roberts syndrome presenting with bilateral Cryptophthalmos: a case report.,2026,10.1093/omcr/omag128,https://pubmed.ncbi.nlm.nih.gov/42438665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,41243968,Pathogenic expansion: fibroblast proliferation fuels fibrosis.,2025,10.1172/jci199180,https://pubmed.ncbi.nlm.nih.gov/41243968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,40796045,ESCO2 drives breast cancer proliferation and metastasis through PI3K/AKT/mTOR phosphorylation: A potential therapeutic target.,2025,10.1016/j.bbamcr.2025.120043,https://pubmed.ncbi.nlm.nih.gov/40796045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,38605349,ESCO2's oncogenic role in human tumors: a pan-cancer analysis and experimental validation.,2024,10.1186/s12885-024-12213-w,https://pubmed.ncbi.nlm.nih.gov/38605349/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,41902797,A Tumor Microenvironment-Derived CAF-VEGF Model and Its Application in Biomarker Screening for HCC.,2026,10.1002/cbf.70204,https://pubmed.ncbi.nlm.nih.gov/41902797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,42103667,[Characterization of copy number variations in concomitant exotropia using single nucleotide polymorphism microarray].,2026,10.3760/cma.j.cn112142-20250815-00350,https://pubmed.ncbi.nlm.nih.gov/42103667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,41255663,"Exploring Roberts syndrome, unique manifestations in a four-month-old infant and genetic findings: A case report.",2025,10.5409/wjcp.v14.i4.110750,https://pubmed.ncbi.nlm.nih.gov/41255663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,41286177,Discovery and validation of proliferative exhausted T cells as a favorable prognostic biomarker in esophageal squamous cell carcinoma.,2025,10.1038/s41598-025-25535-x,https://pubmed.ncbi.nlm.nih.gov/41286177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,20301332,ESCO2 Spectrum Disorder,1993,,https://pubmed.ncbi.nlm.nih.gov/20301332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,39527939,The Potential of ESCO2 as a Prognostic and Immunotherapeutic Marker of Pan-Cancer and Its Role in Anti-PD-1 Treatment of Bladder Cancer.,2025,10.1159/000542188,https://pubmed.ncbi.nlm.nih.gov/39527939/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,37968576,ESCO2 promotes hypopharyngeal carcinoma progression in a STAT1-dependent manner.,2023,10.1186/s12885-023-11527-5,https://pubmed.ncbi.nlm.nih.gov/37968576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,42617351,Machine learning-enabled multi-omics discovery of prognostic biomarkers and signaling targets in pancreatic cancer.,2026,10.1016/j.compbiolchem.2026.109320,https://pubmed.ncbi.nlm.nih.gov/42617351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,40396618,Protein turnover downstream of the Nipbl/CRL4 axis contributes to abnormal development in zebrafish embryos.,2026,10.1002/dvdy.70037,https://pubmed.ncbi.nlm.nih.gov/40396618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,38288163,Case report: The evolving phenotype of ESCO2 spectrum disorder in a 15-year-old Malaysian child.,2023,10.3389/fgene.2023.1286489,https://pubmed.ncbi.nlm.nih.gov/38288163/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,36708487,The cohesin modifier ESCO2 is stable during DNA replication.,2023,10.1007/s10577-023-09711-1,https://pubmed.ncbi.nlm.nih.gov/36708487/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,38447274,Differential anti-viral response to respiratory syncytial virus A in preterm and term infants.,2024,10.1016/j.ebiom.2024.105044,https://pubmed.ncbi.nlm.nih.gov/38447274/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,37702151,CRISPR screens in sister chromatid cohesion defective cells reveal PAXIP1-PAGR1 as regulator of chromatin association of cohesin.,2023,10.1093/nar/gkad756,https://pubmed.ncbi.nlm.nih.gov/37702151/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,37297299,Silver Nanoparticles Induced Changes in DNA Methylation and Histone H3 Methylation in a Mouse Model of Breast Cancer.,2023,10.3390/ma16114163,https://pubmed.ncbi.nlm.nih.gov/37297299/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,38013320,Research on the resistance of isoviolanthin to hydrogen peroxide-triggered injury of skin keratinocytes based on Transcriptome sequencing and molecular docking.,2023,10.1097/md.0000000000036119,https://pubmed.ncbi.nlm.nih.gov/38013320/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,29084713,Cohesin mediates Esco2-dependent transcriptional regulation in a zebrafish regenerating fin model of Roberts Syndrome.,2017,10.1242/bio.026013,https://pubmed.ncbi.nlm.nih.gov/29084713/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,35484177,Identification and validation of prognosis-associated DNA repair gene signatures in colorectal cancer.,2022,10.1038/s41598-022-10561-w,https://pubmed.ncbi.nlm.nih.gov/35484177/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,30746609,Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes.,2019,10.1007/s13365-018-0715-4,https://pubmed.ncbi.nlm.nih.gov/30746609/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,26729373,Improved transcription and translation with L-leucine stimulation of mTORC1 in Roberts syndrome.,2016,10.1186/s12864-015-2354-y,https://pubmed.ncbi.nlm.nih.gov/26729373/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,25744204,Mice lacking the cerebral cortex develop normal song: insights into the foundations of vocal learning.,2015,10.1038/srep08808,https://pubmed.ncbi.nlm.nih.gov/25744204/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,27501381,Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo.,2016,10.3791/54218,https://pubmed.ncbi.nlm.nih.gov/27501381/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,24690595,Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.,2014,10.1093/toxsci/kfu038,https://pubmed.ncbi.nlm.nih.gov/24690595/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,31516082,The expanding phenotypes of cohesinopathies: one ring to rule them all!,2019,10.1080/15384101.2019.1658476,https://pubmed.ncbi.nlm.nih.gov/31516082/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESCO2,ENSG00000171320,Unsafe,15821733,"Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion.",2005,10.1038/ng1548,https://pubmed.ncbi.nlm.nih.gov/15821733/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,41573655,Extra-pancreatic solid pseudopapillary neoplasm: a case report of primary testis origin and review of the literature.,2025,10.3389/fonc.2025.1691249,https://pubmed.ncbi.nlm.nih.gov/41573655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,42879492,FOXG1 spatiotemporally orchestrates subtype fate specification and patch/matrix identity of striatal spiny projection neurons.,2026,10.1073/pnas.2603031123,https://pubmed.ncbi.nlm.nih.gov/42879492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,42160510,Long isoforms of Espin and Espin-Like proteins are essential for development and maintenance of mechanotransducing stereocilia.,2026,10.1091/mbc.e25-07-0360,https://pubmed.ncbi.nlm.nih.gov/42160510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,41876635,Fusobacterium nucleatum promotes tumor extravasation and metastasis in head and neck cancer via TLR4/MYB/ESPN axis.,2026,10.1038/s42003-026-09913-3,https://pubmed.ncbi.nlm.nih.gov/41876635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,41700725,Bone turnover markers in the management of CKD-associated osteoporosis-a European consensus.,2026,10.1093/ndt/gfag033,https://pubmed.ncbi.nlm.nih.gov/41700725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,40346630,ESPN activates ZEB1-mediated EMT through the PI3K/AKT/mTOR axis to promote osteosarcoma metastasis.,2025,10.1186/s12967-025-06500-8,https://pubmed.ncbi.nlm.nih.gov/40346630/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,41761680,Transcontinental Practice Patterns in Pediatric Recurrent Focal Segmental Glomerulosclerosis: Barriers to Consensus and Adequately Powered Studies.,2026,10.1111/petr.70280,https://pubmed.ncbi.nlm.nih.gov/41761680/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,40175630,The state of targeted therapeutic pharmacological approaches in pediatric neurosurgery: report from the European Society for Pediatric Neurosurgery (ESPN) Consensus Conference 2024.,2025,10.1007/s00381-025-06799-0,https://pubmed.ncbi.nlm.nih.gov/40175630/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,39794284,Dent disease: clinical practice recommendations.,2025,10.1093/ndt/gfaf003,https://pubmed.ncbi.nlm.nih.gov/39794284/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,39457374,"Diversity, Distribution and Structural Prediction of the Pathogenic Bacterial Effectors EspN and EspS.",2024,10.3390/genes15101250,https://pubmed.ncbi.nlm.nih.gov/39457374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,39673454,"Diagnosis, management and treatment of the Alport syndrome - 2024 guideline on behalf of ERKNet, ERA and ESPN.",2025,10.1093/ndt/gfae265,https://pubmed.ncbi.nlm.nih.gov/39673454/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,40544678,Curcumin alleviates proliferation dysfunction in chicken granulosa cells under oxidative stress through AKT-Raf1-ERK1/2 signaling pathway.,2025,10.1016/j.psj.2025.105342,https://pubmed.ncbi.nlm.nih.gov/40544678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,42757209,Assessing Return to Performance After Surgery in National Football League Quarterbacks: A Comparative Analysis of Performance Metrics.,2026,10.7759/cureus.114758,https://pubmed.ncbi.nlm.nih.gov/42757209/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,39875204,"The role of nutritional vitamin D in chronic kidney disease-mineral and bone disorder in children and adults with chronic kidney disease, on dialysis, and after kidney transplantation-a European consensus statement.",2025,10.1093/ndt/gfae293,https://pubmed.ncbi.nlm.nih.gov/39875204/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,42502501,Short-Term Workload Patterns Before Achilles Tendon Rupture in National Basketball Association Players: A Descriptive Epidemiology Study.,2026,10.1177/23259671261463385,https://pubmed.ncbi.nlm.nih.gov/42502501/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,38445877,"The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in &lt;i&gt;M. marinum&lt;/i&gt;.",2024,10.1128/mbio.03357-23,https://pubmed.ncbi.nlm.nih.gov/38445877/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,40365278,Shh agonist enhances maturation in homotypic Lgr5-positive inner ear organoids.,2025,10.7150/thno.107345,https://pubmed.ncbi.nlm.nih.gov/40365278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,41501585,Vascular access for hemodialysis and catheter-related bloodstream infections: a survey on preventive measures and treatment strategies by the EPDWG and ESPN Dialysis Working Group.,2026,10.1007/s00431-025-06703-7,https://pubmed.ncbi.nlm.nih.gov/41501585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,40428348,Whole-Genome DNA Methylation Analysis in Age-Related Hearing Loss.,2025,10.3390/genes16050526,https://pubmed.ncbi.nlm.nih.gov/40428348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,42147990,Beyond Living Donor Kidney Transplantation in COL4 Nephropathy - A Real-World Clinical Dilemma in Light of Current Guidelines.,2025,10.2478/bjmg-2025-00022,https://pubmed.ncbi.nlm.nih.gov/42147990/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,39989336,Kidney Transplantation in Children and Adolescents With C3 Glomerulopathy or Immune Complex Membranoproliferative Glomerulonephritis: An International Survey of Current Practice.,2025,10.1111/petr.70048,https://pubmed.ncbi.nlm.nih.gov/39989336/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,39984743,"Global access to management of primary hyperoxaluria: a survey on behalf of OxalEurope, G&amp;K Working Group of the ERA and ESPN.",2025,10.1093/ndt/gfaf035,https://pubmed.ncbi.nlm.nih.gov/39984743/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,38916228,"Comparative Whole-Genome Sequencing Analysis of In-situ and Invasive Acral Lentiginous Melanoma: Markedly Increased Copy Number Gains of GAB2 , PAK1 , UCP2 , and CCND1 are Associated with Melanoma Invasion.",2024,10.1097/pas.0000000000002273,https://pubmed.ncbi.nlm.nih.gov/38916228/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,34432141,"Abstracts of the 53rd ESPN Annual Meeting, Amsterdam, The Netherlands, September 2021.",2021,10.1007/s00467-021-05210-9,https://pubmed.ncbi.nlm.nih.gov/34432141/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,35532778,Protocol for the multicentre prospective paediatric craniectomy and cranioplasty registry (pedCCR) under the auspices of the European Society for Paediatric Neurosurgery (ESPN).,2022,10.1007/s00381-022-05540-5,https://pubmed.ncbi.nlm.nih.gov/35532778/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,38456922,Intracranial complications of sinogenic and otogenic infections in children: an ESPN survey on their occurrence in the pre-COVID and post-COVID era.,2024,10.1007/s00381-024-06332-9,https://pubmed.ncbi.nlm.nih.gov/38456922/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,36786859,Diagnosis and management of mineral and bone disorders in infants with CKD: clinical practice points from the ESPN CKD-MBD and Dialysis working groups and the Pediatric Renal Nutrition Taskforce.,2023,10.1007/s00467-022-05825-6,https://pubmed.ncbi.nlm.nih.gov/36786859/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,39031848,"Asciminib, a novel allosteric inhibitor of BCR-ABL1, shows synergistic effects when used in combination with imatinib with or without drug resistance.",2024,10.1002/prp2.1214,https://pubmed.ncbi.nlm.nih.gov/39031848/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,34971403,Impact of coronavirus disease-2019 on pediatric nephrology practice and education: an ESPN survey.,2022,10.1007/s00467-021-05226-1,https://pubmed.ncbi.nlm.nih.gov/34971403/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,39759883,"Achievements, priorities and strategies in pediatric nephrology in Europe: need for unifying approaches or acceptance of differences?",2024,10.3389/fped.2024.1458003,https://pubmed.ncbi.nlm.nih.gov/39759883/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,33514942,Management of congenital nephrotic syndrome: consensus recommendations of the ERKNet-ESPN Working Group.,2021,10.1038/s41581-020-00384-1,https://pubmed.ncbi.nlm.nih.gov/33514942/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,36059470,Identification of necroptosis-related subtypes and prognosis model in triple negative breast cancer.,2022,10.3389/fimmu.2022.964118,https://pubmed.ncbi.nlm.nih.gov/36059470/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPN,ENSG00000187017,Unsafe,37014530,Rituximab-associated hypogammaglobulinemia in children with idiopathic nephrotic syndrome: results of an ESPN survey.,2023,10.1007/s00467-023-05913-1,https://pubmed.ncbi.nlm.nih.gov/37014530/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPNL,ENSG00000144488,Unsafe,42160510,Long isoforms of Espin and Espin-Like proteins are essential for development and maintenance of mechanotransducing stereocilia.,2026,10.1091/mbc.e25-07-0360,https://pubmed.ncbi.nlm.nih.gov/42160510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPNL,ENSG00000144488,Unsafe,41866947,Nucleolin is essential for hair cell stereocilia maintenance and auditory function in mice.,2026,10.1242/jcs.264793,https://pubmed.ncbi.nlm.nih.gov/41866947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPNL,ENSG00000144488,Unsafe,26926603,Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like.,2016,10.1038/ncomms10833,https://pubmed.ncbi.nlm.nih.gov/26926603/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPNL,ENSG00000144488,Unsafe,30320886,A Whole Methylome Study of Ethanol Exposure in Brain and Blood: An Exploration of the Utility of Peripheral Blood as Proxy Tissue for Brain in Alcohol Methylation Studies.,2018,10.1111/acer.13905,https://pubmed.ncbi.nlm.nih.gov/30320886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPNL,ENSG00000144488,Unsafe,33151556,Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness.,2021,10.1113/jp280670,https://pubmed.ncbi.nlm.nih.gov/33151556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPNL,ENSG00000144488,Unsafe,33188484,Identification of immune-related gene signature predicting survival in the tumor microenvironment of lung adenocarcinoma.,2020,10.1007/s00251-020-01189-z,https://pubmed.ncbi.nlm.nih.gov/33188484/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPNL,ENSG00000144488,Unsafe,30898391,Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.,2019,10.1016/j.ygyno.2019.02.023,https://pubmed.ncbi.nlm.nih.gov/30898391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESPNL,ENSG00000144488,Unsafe,25582750,Identification of stage-specific markers during differentiation of hair cells from mouse inner ear stem cells or progenitor cells in vitro.,2015,10.1016/j.biocel.2014.12.024,https://pubmed.ncbi.nlm.nih.gov/25582750/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42791807,Establishment and Characterization of a Brain-Derived Cell Line from Japanese Eel (&lt;i&gt;Anguilla Japonica&lt;/i&gt;) and Transcriptomic Analysis of Its Responses to Sex Steroid Hormones.,2026,10.3390/ani16182951,https://pubmed.ncbi.nlm.nih.gov/42791807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,41054802,"Polychlorinated Biphenyls Alter Estrogen Receptor β-mediated Epigenetic Regulation, Promoting Endometriosis.",2025,10.1210/endocr/bqaf146,https://pubmed.ncbi.nlm.nih.gov/41054802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42896796,Exploratory chromosome 14-focused transcriptomic profiling of PSEN1-associated familial Alzheimer's disease across brain regions.,2026,10.1016/j.bbapap.2026.141192,https://pubmed.ncbi.nlm.nih.gov/42896796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42795391,"Prenatal and Lactation Exposure to Bisphenol A (BPA) at the Global Mean Daily Intake Level Leads to Sex-Dependent Changes in Microglial State, Gene Expression, and Behavioral Patterns in Newborn and Juvenile Wistar Rat Offspring.",2026,10.3390/life16091526,https://pubmed.ncbi.nlm.nih.gov/42795391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,41470754,Anthocyanin-Rich Blackcurrant Pomace Mitigates Oxidative Stress and Affects Steroid Metabolism in the Testes of Rats Exposed to Silver Nanoparticles.,2025,10.3390/nu17243809,https://pubmed.ncbi.nlm.nih.gov/41470754/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42216964,Synaptic Mitochondrial Respiration Differs Between the Prefrontal Cortex and Hippocampus in C57Bl/6NTac Mice.,2026,10.1007/s12035-026-05961-2,https://pubmed.ncbi.nlm.nih.gov/42216964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,41543558,Optimized selection of specific antibodies against rodent ESR1 proteins and their application for immunohistochemistry and dual immunohistofluorescence with the specific anti-ESR2 antibody PPZ0506.,2026,10.1007/s00418-025-02454-6,https://pubmed.ncbi.nlm.nih.gov/41543558/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42219575,Estrogen receptor β regulates sex-dependent airway mechanics and inflammation in a murine model of allergen exposure.,2026,10.14814/phy2.70948,https://pubmed.ncbi.nlm.nih.gov/42219575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,41744679,ESR2 Regulates Granulosa Cell Proliferation and Steroidogenesis via the PI3K/AKT/mTOR Signaling Pathway in Wuding Chickens.,2026,10.3390/biology15040370,https://pubmed.ncbi.nlm.nih.gov/41744679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42395267,"Methylation of the &lt;i&gt;BMP6&lt;/i&gt;, &lt;i&gt;BRCA1&lt;/i&gt;, &lt;i&gt;ESR2&lt;/i&gt;, &lt;i&gt;GSTP1&lt;/i&gt; and &lt;i&gt;TIMP3&lt;/i&gt; genes in Mexican women with breast cancer and benign disease.",2026,10.3892/ol.2026.15723,https://pubmed.ncbi.nlm.nih.gov/42395267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42248903,Effect of ESR1 and ESR2 polymorphisms on ovarian response in assisted reproductive technology cycles: a systematic review and meta-analysis.,2026,10.1038/s41598-026-53350-5,https://pubmed.ncbi.nlm.nih.gov/42248903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,41715211,Sex chromosome-dependent epigenetic regulation underlies sex-specific H4 acetylation at the aromatase promoter in the developing mouse amygdala.,2026,10.1186/s13293-026-00854-4,https://pubmed.ncbi.nlm.nih.gov/41715211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,39201394,Genes Co-Expressed with ESR2 Influence Clinical Outcomes in Cancer Patients: TCGA Data Analysis.,2024,10.3390/ijms25168707,https://pubmed.ncbi.nlm.nih.gov/39201394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42794985,Comparative Gene Expression Analysis of Epithelioid Pleural and Peritoneal Mesothelioma.,2026,10.3390/cancers18183018,https://pubmed.ncbi.nlm.nih.gov/42794985/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42208172,Maternal protein undernutrition during lactation reduces body weight gain and adiposity and delays pubertal onset in male Wistar offspring.,2026,10.1016/j.nut.2026.113247,https://pubmed.ncbi.nlm.nih.gov/42208172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42750181,Restraint stress impairs oocyte maturation via dysregulating stage-dependent estradiol-BMAL 1 rhythm in mice.,2026,10.1093/reprod/xaag118,https://pubmed.ncbi.nlm.nih.gov/42750181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,41563281,Matrix Stiffness Directs Early Injury and Ketogenesis Programs to Prime Kidney Repair.,2026,10.1681/asn.0000000967,https://pubmed.ncbi.nlm.nih.gov/41563281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42202562,FOXO3 regulated granulosa cells apoptosis and AKT1 phosphorylation in Muscovy duck follicles (Cairina moschata).,2026,10.1016/j.psj.2026.107041,https://pubmed.ncbi.nlm.nih.gov/42202562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,41153361,In Silico Characterization of Pathogenic &lt;i&gt;ESR2&lt;/i&gt; Coding and UTR Variants as Oncogenic Potential Biomarkers in Hormone-Dependent Cancers.,2025,10.3390/genes16101144,https://pubmed.ncbi.nlm.nih.gov/41153361/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,40890245,"LBX1, ESR1, and ESR2 genes DNA methylation level in idiopathic scoliosis.",2025,10.1038/s41598-025-15804-0,https://pubmed.ncbi.nlm.nih.gov/40890245/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42853327,Mechanistic assessment of hepato-reproductive toxicity of Mentha pulegium L. essential oil in rats.,2026,10.1007/s11033-026-12842-3,https://pubmed.ncbi.nlm.nih.gov/42853327/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42177213,"Exploring the mechanism of stigmasterol against androgenetic alopecia using geometry optimization, network pharmacology, molecular docking, and molecular dynamics studies.",2026,10.1038/s41598-026-52929-2,https://pubmed.ncbi.nlm.nih.gov/42177213/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42064774,"Cadmium chloride and erectile dysfunction: integrative evidence from network toxicology, Mendelian randomization, and &lt;i&gt;in vitro&lt;/i&gt; validation.",2026,10.3389/fendo.2026.1798494,https://pubmed.ncbi.nlm.nih.gov/42064774/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,40512387,A network toxicology approach to decipher paraben-induced molecular dysregulation in breast cancer pathogenesis.,2025,10.1007/s12672-025-02884-7,https://pubmed.ncbi.nlm.nih.gov/40512387/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,41372233,Repurposing clinically safe drugs for DNA repair pathway choice in CRISPR genome editing and synthetic lethality.,2025,10.1038/s41467-025-67243-0,https://pubmed.ncbi.nlm.nih.gov/41372233/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,41601053,Exploring key genes related to air pollutants in polycystic ovary syndrome: A comprehensive analysis from transcriptome and single-cell analysis combined with network toxicology.,2026,10.1016/j.ecoenv.2025.119623,https://pubmed.ncbi.nlm.nih.gov/41601053/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42600487,Integrative computational toxicology and experimental validation unveils ESR1-mediated steroidogenic disruption in triphenyl phosphate-induced female reproductive toxicity.,2026,10.1016/j.envint.2026.110458,https://pubmed.ncbi.nlm.nih.gov/42600487/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42721757,"Chronic labetalol exposure induced dose-dependent testicular toxicity via disruptingt HPG-axis, spermatogenesis and steroidogenic pathways: A biochemical, molecular and histopathological evidence.",2026,10.1016/j.tice.2026.103924,https://pubmed.ncbi.nlm.nih.gov/42721757/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42345808,"The Effects of Bisphosphonates Used in Osteoporosis Treatment on Breast Cancer: Analysis with Integrative Bioinformatics Methods, DFT, ADMET and Molecular Docking Analysis.",2026,10.3390/biology15120952,https://pubmed.ncbi.nlm.nih.gov/42345808/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42119666,"FSH mediated endocrine disruption potential of Dibutyl phthalate in cultured ovine ovarian granulosa cells: Cytotoxicity, oxidative stress, steroidogenesis, cell senescence, and expression of related key developmental genes.",2026,10.1016/j.reprotox.2026.109262,https://pubmed.ncbi.nlm.nih.gov/42119666/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,41601079,Association between gestational and lactational DCBQ exposure and developmental toxicity in female offspring: Potential role of gut microbiota dysbiosis.,2026,10.1016/j.ecoenv.2025.119654,https://pubmed.ncbi.nlm.nih.gov/41601079/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42889033,Female hormones enhance skin T cell expansion and suppress IFN-γ production.,2026,10.3389/fimmu.2026.1903552,https://pubmed.ncbi.nlm.nih.gov/42889033/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42224416,Environmental Levels of Sodium p-Perfluorous Nonenoxybenzene Sulfonate Induce Nephritis in Renal Proximal Tubular Epithelial Cells via Modulation of Estrogen Signaling Pathways.,2026,10.1002/jbt.70948,https://pubmed.ncbi.nlm.nih.gov/42224416/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,41865090,"Investigating the mechanistic link between pesticide DDT and breast cancer through network toxicology, molecular docking, and molecular dynamics simulation.",2026,10.1038/s41598-025-20169-5,https://pubmed.ncbi.nlm.nih.gov/41865090/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,41737726,Sex-informed estrogen receptor modulation in schizophrenia: a male-focused ERβ/GPER1 framework for cognitive and negative symptoms.,2025,10.3389/fpsyt.2025.1714569,https://pubmed.ncbi.nlm.nih.gov/41737726/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,39891710,Interaction between Estrogen Receptors and p53: A Broader Role for Tamoxifen?,2025,10.1210/endocr/bqaf020,https://pubmed.ncbi.nlm.nih.gov/39891710/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,41386056,Investigating the mechanism by which nonylphenol disrupts human sperm motility via network toxicology.,2026,10.1016/j.ecoenv.2025.119553,https://pubmed.ncbi.nlm.nih.gov/41386056/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,42168279,Computational screening of natural compounds from traditional Persian medicinal plant for the finding of potential antidepressant.,2026,10.1038/s41598-026-53032-2,https://pubmed.ncbi.nlm.nih.gov/42168279/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESR2,ENSG00000140009,Unsafe,9636657,Cloning and characterization of human estrogen receptor beta isoforms.,1998,10.1006/bbrc.1998.8738,https://pubmed.ncbi.nlm.nih.gov/9636657/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,40032835,Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites.,2025,10.1038/s41467-025-57405-5,https://pubmed.ncbi.nlm.nih.gov/40032835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,42134546,"Quantitative FRET FLIM imaging reveals multiple interactions between proteins of the ESYT, ORP, and VAP families at the endoplasmic reticulum membrane.",2026,10.1016/j.jbc.2026.113144,https://pubmed.ncbi.nlm.nih.gov/42134546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,41466414,"Genome-wide association for sarcoidosis identifies novel risk loci and genetic heritability in African and European ancestries: a meta-analysis from the Finngen, Million Veteran Program, UK Biobank, and Biobank Japan datasets.",2025,10.1186/s13023-025-04097-1,https://pubmed.ncbi.nlm.nih.gov/41466414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,38245550,Early-stage idiopathic Parkinson's disease is associated with reduced circular RNA expression.,2024,10.1038/s41531-024-00636-y,https://pubmed.ncbi.nlm.nih.gov/38245550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,36129976,The genetic architecture of phenotypic diversity in the Betta fish (Betta splendens).,2022,10.1126/sciadv.abm4955,https://pubmed.ncbi.nlm.nih.gov/36129976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,32879390,The short isoform of extended synaptotagmin-2 controls Ca2+ dynamics in T cells via interaction with STIM1.,2020,10.1038/s41598-020-71489-7,https://pubmed.ncbi.nlm.nih.gov/32879390/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,27555542,A large-scale analysis of alternative splicing reveals a key role of QKI in lung cancer.,2016,10.1016/j.molonc.2016.08.001,https://pubmed.ncbi.nlm.nih.gov/27555542/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,25486202,"Loss of Extended Synaptotagmins ESyt2 and ESyt3 does not affect mouse development or viability, but in vitro cell migration and survival under stress are affected.",2014,10.4161/15384101.2014.943573,https://pubmed.ncbi.nlm.nih.gov/25486202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,27348751,Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction.,2016,10.1371/journal.pone.0158295,https://pubmed.ncbi.nlm.nih.gov/27348751/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,30499115,Membrane proteome characterization of periodontal ligament cell sets from deciduous and permanent teeth.,2019,10.1002/jper.18-0217,https://pubmed.ncbi.nlm.nih.gov/30499115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,34509914,Chemoproteomic profiling reveals cellular targets of nitro-fatty acids.,2021,10.1016/j.redox.2021.102126,https://pubmed.ncbi.nlm.nih.gov/34509914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,35117599,Data independent acquisition-mass spectrometry (DIA-MS)-based comprehensive profiling of bone metastatic cancers revealed molecular fingerprints to assist clinical classifications for bone metastasis of unknown primary (BMUP).,2020,10.21037/tcr.2020.03.41,https://pubmed.ncbi.nlm.nih.gov/35117599/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,25922075,"Extended Synaptotagmin Interaction with the Fibroblast Growth Factor Receptor Depends on Receptor Conformation, Not Catalytic Activity.",2015,10.1074/jbc.m115.656918,https://pubmed.ncbi.nlm.nih.gov/25922075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,28577945,Systematic identification of cancer-related long noncoding RNAs and aberrant alternative splicing of quintuple-negative lung adenocarcinoma through RNA-Seq.,2017,10.1016/j.lungcan.2017.04.009,https://pubmed.ncbi.nlm.nih.gov/28577945/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,24013099,Combined deletion of two Condensin II system genes (NCAPG2 and MCPH1) in a case of severe microcephaly and mental deficiency.,2013,10.1016/j.ejmg.2013.07.007,https://pubmed.ncbi.nlm.nih.gov/24013099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,29154949,A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic.,2018,10.1016/j.bbamcr.2017.11.009,https://pubmed.ncbi.nlm.nih.gov/29154949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,28075048,The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis.,2017,10.1002/jcb.25880,https://pubmed.ncbi.nlm.nih.gov/28075048/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,27772752,Role of neurodevelopment involved genes in psychiatric comorbidities and modulation of inflammatory processes in Alzheimer's disease.,2016,10.1016/j.jns.2016.09.053,https://pubmed.ncbi.nlm.nih.gov/27772752/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,22248381,Proteomic study of the mucin granulae in an intestinal goblet cell model.,2012,10.1021/pr2010988,https://pubmed.ncbi.nlm.nih.gov/22248381/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,19661783,Candidate genes associated with malignant pheochromocytomas by genome-wide expression profiling.,2009,10.1097/sla.0b013e3181b248bb,https://pubmed.ncbi.nlm.nih.gov/19661783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ESYT2,ENSG00000117868,Unsafe,17360437,"E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains.",2007,10.1073/pnas.0611725104,https://pubmed.ncbi.nlm.nih.gov/17360437/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETFBKMT,ENSG00000139160,Unsafe,41539647,"Energy production is suppressed by vcircRNA_000048- bom-miR-2753-METTL20 regulatory axis in the BmCPV-infected silkworm, Bombyx mori.",2026,10.1016/j.ibmb.2026.104496,https://pubmed.ncbi.nlm.nih.gov/41539647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETFBKMT,ENSG00000139160,Unsafe,42190389,"Mechanisms of testicular toxicity uncovered by multi-omics: 9,10-epoxy stearic acid as a foodborne contaminant in mice.",2026,10.1016/j.ecoenv.2026.120299,https://pubmed.ncbi.nlm.nih.gov/42190389/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETFBKMT,ENSG00000139160,Unsafe,39809816,"Integrated TWAS, GWAS, and RNAseq results identify candidate genes associated with reproductive traits in cows.",2025,10.1038/s41598-024-82448-x,https://pubmed.ncbi.nlm.nih.gov/39809816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETFBKMT,ENSG00000139160,Unsafe,41652423,Antitumor efficacy and molecular mechanism of lenvatinib combined with vitamin K2 against hepatocellular carcinoma.,2026,10.1186/s12957-026-04235-4,https://pubmed.ncbi.nlm.nih.gov/41652423/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETFBKMT,ENSG00000139160,Unsafe,37563198,A cryptic microdeletion del(12)(p11.21p11.23) within an unbalanced translocation t(7;12)(q21.13;q23.1) implicates new candidate loci for intellectual disability and Kallmann syndrome.,2023,10.1038/s41598-023-40037-4,https://pubmed.ncbi.nlm.nih.gov/37563198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETFBKMT,ENSG00000139160,Unsafe,29352221,Role of METTL20 in regulating β-oxidation and heat production in mice under fasting or ketogenic conditions.,2018,10.1038/s41598-018-19615-4,https://pubmed.ncbi.nlm.nih.gov/29352221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETFBKMT,ENSG00000139160,Unsafe,37668531,Mediator subunit MED1 deficiency prevents carbon tetrachloride-induced hepatic fibrosis in mice.,2023,10.1152/ajpgi.00076.2023,https://pubmed.ncbi.nlm.nih.gov/37668531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETFBKMT,ENSG00000139160,Unsafe,31937794,Exploring the Novel Susceptibility Gene Variants for Primary Open-Angle Glaucoma in East Asian Cohorts: The GLAU-GENDISK Study.,2020,10.1038/s41598-019-57066-7,https://pubmed.ncbi.nlm.nih.gov/31937794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETFBKMT,ENSG00000139160,Unsafe,25416781,Human METTL20 is a mitochondrial lysine methyltransferase that targets the β subunit of electron transfer flavoprotein (ETFβ) and modulates its activity.,2015,10.1074/jbc.m114.614115,https://pubmed.ncbi.nlm.nih.gov/25416781/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETFBKMT,ENSG00000139160,Unsafe,26929405,The METTL20 Homologue from Agrobacterium tumefaciens Is a Dual Specificity Protein-lysine Methyltransferase That Targets Ribosomal Protein L7/L12 and the β Subunit of Electron Transfer Flavoprotein (ETFβ).,2016,10.1074/jbc.m115.709261,https://pubmed.ncbi.nlm.nih.gov/26929405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETFBKMT,ENSG00000139160,Unsafe,25023281,Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondria.,2014,10.1074/jbc.m114.580464,https://pubmed.ncbi.nlm.nih.gov/25023281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETFRF1,ENSG00000205707,Unsafe,36266680,"orsai, the Drosophila homolog of human ETFRF1, links lipid catabolism to growth control.",2022,10.1186/s12915-022-01417-w,https://pubmed.ncbi.nlm.nih.gov/36266680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETFRF1,ENSG00000205707,Unsafe,35402183,CircPTN promotes angiogenesis via the MiR-595/LYRM5 signaling pathway in non-small cell lung cancer.,2022,10.21037/tcr-22-195,https://pubmed.ncbi.nlm.nih.gov/35402183/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETFRF1,ENSG00000205707,Unsafe,27499296,Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.,2016,10.1016/j.molcel.2016.06.033,https://pubmed.ncbi.nlm.nih.gov/27499296/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,42457676,Targeting the microglial phosphatidylethanolamine synthesis pathway promotes GABARAP-associated phagocytosis and Aβ clearance in Alzheimer's disease.,2026,10.1038/s41392-026-02789-z,https://pubmed.ncbi.nlm.nih.gov/42457676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,42003071,Cyclophosphamide Induces Autophagy-Dependent Ferroptosis Through Promoting ETNK1 Expression in Breast Cancer Cells.,2026,10.1002/ddr.70289,https://pubmed.ncbi.nlm.nih.gov/42003071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,40040525,Analysis of Differentially Expressed Proteins in Bovine Mammary Glands Infected with &lt;i&gt;Staphylococcus aureus&lt;/i&gt;.,2026,10.1089/fpd.2024.0179,https://pubmed.ncbi.nlm.nih.gov/40040525/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,42180928,Lipid metabolism-related gene expression predicts prognostic outcomes in lung adenocarcinoma.,2026,10.21037/tcr-2025-1-2665,https://pubmed.ncbi.nlm.nih.gov/42180928/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,40937562,Integrated metabolomics and transcriptomics analyses reveal changes in metabolites and their associated gene expression in the blood of patients with recurrent HSV‑2 genital herpes.,2025,10.3892/mmr.2025.13681,https://pubmed.ncbi.nlm.nih.gov/40937562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,40074445,Comprehensive systems biology analysis of microRNA-101-3p regulatory network identifies crucial genes and pathways in hepatocellular carcinoma.,2025,10.1016/j.jgeb.2025.100471,https://pubmed.ncbi.nlm.nih.gov/40074445/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,40949920,Comprehensive analysis of a lipid metabolism-related gene signature for ulcerative colitis.,2025,10.21037/tp-2025-161,https://pubmed.ncbi.nlm.nih.gov/40949920/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,38694857,MiR-103a-3p Promotes Tumorigenesis of Breast Cancer by Targeting ETNK1.,2024,10.18502/ijph.v53i1.14697,https://pubmed.ncbi.nlm.nih.gov/38694857/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,40149693,Proteome-Wide Analysis of Autoantibodies in Open-Angle Glaucoma in Japanese Population: A Pilot Study.,2025,10.3390/biomedicines13030718,https://pubmed.ncbi.nlm.nih.gov/40149693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,41378161,Atypical chronic myeloid leukemia: From diagnosis to molecular features and therapeutic options.,2025,10.1002/hem3.70270,https://pubmed.ncbi.nlm.nih.gov/41378161/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,40712585,HIF-independent oxygen sensing via KDM6A regulates ferroptosis.,2025,10.1016/j.molcel.2025.07.001,https://pubmed.ncbi.nlm.nih.gov/40712585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,41463042,An Exploratory Study of Machine Learning-Based Open-Angle Glaucoma Detection Using Specific Autoantibodies.,2025,10.3390/biomedicines13123031,https://pubmed.ncbi.nlm.nih.gov/41463042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,41772422,Multi-omics reveals glycolipid metabolism processes during the early development of largemouth bass (Micropterus salmoides).,2026,10.1186/s12864-026-12692-0,https://pubmed.ncbi.nlm.nih.gov/41772422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,37809692,miR-708-3p promotes gastric cancer progression through downregulating ETNK1.,2023,10.1016/j.heliyon.2023.e19544,https://pubmed.ncbi.nlm.nih.gov/37809692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,36987411,Lncrna FEZf1-as1 negatively regulates ETNK1 to promote malignant progression of renal cell carcinoma.,2023,10.5937/jomb0-39710,https://pubmed.ncbi.nlm.nih.gov/36987411/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,39042872,Molecular and clinical characterization of ETNK1-mutated myeloid neoplasms: the Mayo Clinic experience.,2024,10.1182/bloodadvances.2024013255,https://pubmed.ncbi.nlm.nih.gov/39042872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,40977549,Identification of metabolism regulators as diagnostic markers for ulcerative colitis and their correlation with immune infiltration.,2025,10.5114/pjp.2025.153972,https://pubmed.ncbi.nlm.nih.gov/40977549/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,38066919,Atypical CML: diagnosis and treatment.,2023,10.1182/hematology.2023000448,https://pubmed.ncbi.nlm.nih.gov/38066919/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,38130634,A pan-cancer analysis of the oncogenic role of Golgi transport 1B in human tumors.,2023,10.2478/jtim-2023-0002,https://pubmed.ncbi.nlm.nih.gov/38130634/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,38157930,Acquisition of Drug Resistance in Basal Cell Nevus Syndrome Tumors through Basal to Squamous Cell Carcinoma Transition.,2024,10.1016/j.jid.2023.10.040,https://pubmed.ncbi.nlm.nih.gov/38157930/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,35745070,Screening of Specific and Common Pathways in Breast Cancer Cell Lines MCF-7 and MDA-MB-231 Treated with Chlorophyllides Composites.,2022,10.3390/molecules27123950,https://pubmed.ncbi.nlm.nih.gov/35745070/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,32962122,Atypical Chronic Myeloid Leukemia: Where Are We Now?,2020,10.3390/ijms21186862,https://pubmed.ncbi.nlm.nih.gov/32962122/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,34234346,Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine.,2021,10.1038/s41586-021-03692-z,https://pubmed.ncbi.nlm.nih.gov/34234346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,34884997,Integrated Clinical Genotype-Phenotype Characteristics of Blastic Plasmacytoid Dendritic Cell Neoplasm.,2021,10.3390/cancers13235888,https://pubmed.ncbi.nlm.nih.gov/34884997/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,21875690,Metabolic link between phosphatidylethanolamine and triacylglycerol metabolism in the yeast Saccharomyces cerevisiae.,2011,10.1016/j.bbalip.2011.08.007,https://pubmed.ncbi.nlm.nih.gov/21875690/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,20217129,Identification of genes related to a synergistic effect of taxane and suberoylanilide hydroxamic acid combination treatment in gastric cancer cells.,2010,10.1007/s00432-010-0849-0,https://pubmed.ncbi.nlm.nih.gov/20217129/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,22208759,Analysis of the toxicogenomic effects of exposure to persistent organic pollutants (POPs) in Slovakian girls: correlations between gene expression and disease risk.,2012,10.1016/j.envint.2011.09.003,https://pubmed.ncbi.nlm.nih.gov/22208759/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETNK1,ENSG00000139163,Unsafe,11044454,Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway.,2001,10.1074/jbc.m008794200,https://pubmed.ncbi.nlm.nih.gov/11044454/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,42585327,TAL1 is indispensable in ETV2-primed human endothelial cell fate determination.,2026,10.1126/sciadv.aef9769,https://pubmed.ncbi.nlm.nih.gov/42585327/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,41814973,ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models.,2026,10.1002/adhm.202504849,https://pubmed.ncbi.nlm.nih.gov/41814973/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,42811800,ETV2 functions as a pioneer factor and regulates endothelial progenitor cell proliferation.,2026,10.1080/15384101.2026.2736317,https://pubmed.ncbi.nlm.nih.gov/42811800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,41272813,APPswe mutation causes functional deficits in endothelial cells generated by transient ETV2 overexpression in human iPSCs.,2025,10.1186/s12987-025-00728-8,https://pubmed.ncbi.nlm.nih.gov/41272813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,39811655,"ETV2/ER71 regulates hematovascular lineage generation and vascularization through an H3K9 demethylase, KDM4A.",2025,10.1016/j.isci.2024.111538,https://pubmed.ncbi.nlm.nih.gov/39811655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,42808469,Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia-Like Cells.,2026,10.1002/advs.77668,https://pubmed.ncbi.nlm.nih.gov/42808469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,42287924,ETV2 for endothelial fate specification.,2026,10.1016/j.gde.2026.102502,https://pubmed.ncbi.nlm.nih.gov/42287924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,41351841,Protocol for generation of endothelial cells from human-derived iPSCs and integration into mouse brain explants.,2025,10.1016/j.xpro.2025.104239,https://pubmed.ncbi.nlm.nih.gov/41351841/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,41307047,The Role of Vitamin D Metabolism-Related Genes in Recurrent Pregnancy Loss and Their Immune Microenvironmental Changes.,2025,10.2147/jmdh.s541670,https://pubmed.ncbi.nlm.nih.gov/41307047/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,40612712,mRNA-based &lt;i&gt;in vivo&lt;/i&gt; induction of ETV2 to restore blood flow in a preclinical mouse hindlimb ischemia model.,2025,10.1016/j.omtn.2025.102592,https://pubmed.ncbi.nlm.nih.gov/40612712/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,41420864,"Distinct contributions of Etv2&lt;sup&gt;+&lt;/sup&gt; and Flk1&lt;sup&gt;+&lt;/sup&gt; progenitors to endothelial, hematopoietic, and cardiac lineages.",2026,10.1016/j.celrep.2025.116733,https://pubmed.ncbi.nlm.nih.gov/41420864/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,42446805,Generation of synthetic vascular organoids via orthogonal programming of human pluripotent stem cells.,2026,10.1186/s13619-026-00298-6,https://pubmed.ncbi.nlm.nih.gov/42446805/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,36927793,"ETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogramming.",2023,10.1186/s13287-023-03267-x,https://pubmed.ncbi.nlm.nih.gov/36927793/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,42288671,ETS-guided iPSC-endothelial models recapitulate malaria pathogenesis.,2026,10.1038/s44321-026-00467-9,https://pubmed.ncbi.nlm.nih.gov/42288671/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,41892358,Glycolytic Enzymes Are Part of an Oncogenic Network in AML.,2026,10.3390/cells15060569,https://pubmed.ncbi.nlm.nih.gov/41892358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,41950328,Vasculogenic tissue nanotransfection accelerates functional recovery after peripheral nerve injury.,2026,10.1126/sciadv.aeb7631,https://pubmed.ncbi.nlm.nih.gov/41950328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,41447524,Protocol for generating human vascular organoids via orthogonal activation of ETV2 and NKX3.1.,2026,10.1016/j.xpro.2025.104294,https://pubmed.ncbi.nlm.nih.gov/41447524/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,40832854,"The pioneer factor, ETV2, regulates networks to specify the embryonic endothelial lineage.",2025,10.1093/cvr/cvaf127,https://pubmed.ncbi.nlm.nih.gov/40832854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,41957080,Accelerated reprogramming of hiPSCs into functional brain endothelial-like cells using multiplexed CRISPR activation.,2026,10.1038/s41598-026-46961-5,https://pubmed.ncbi.nlm.nih.gov/41957080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,41491209,Vascularized human brain organoids as a model of the brain-peripheral axis in HIV-1 neuropathogenesis.,2026,10.1038/s41598-025-33940-5,https://pubmed.ncbi.nlm.nih.gov/41491209/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,42600038,Integration of Bulk RNA Sequencing and Single-Cell Sequencing to Identify Prognostic Genes Associated With MCDRGs in Neuroblastoma.,2026,10.1096/fj.202601255r,https://pubmed.ncbi.nlm.nih.gov/42600038/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,42123704,An Integrative ATAC-Seq and RNA-Seq Analysis of Spleen Tissues from Largemouth Bass (&lt;i&gt;Micropterus salmoides&lt;/i&gt;) Infected with Iridovirus (LMBV).,2026,10.3390/ijms27094124,https://pubmed.ncbi.nlm.nih.gov/42123704/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,38570190,"ETV2 induces endothelial, but not hematopoietic, lineage specification in birds.",2024,10.26508/lsa.202402694,https://pubmed.ncbi.nlm.nih.gov/38570190/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,38549772,ETV2 regulating PHD2-HIF-1α axis controls metabolism reprogramming promotes vascularized bone regeneration.,2024,10.1016/j.bioactmat.2024.02.014,https://pubmed.ncbi.nlm.nih.gov/38549772/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,39075623,BCL6B-dependent suppression of ETV2 hampers endothelial cell differentiation.,2024,10.1186/s13287-024-03832-y,https://pubmed.ncbi.nlm.nih.gov/39075623/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,31534512,ETV2/ER71 Transcription Factor as a Therapeutic Vehicle for Cardiovascular Disease.,2019,10.7150/thno.35300,https://pubmed.ncbi.nlm.nih.gov/31534512/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,41390669,Targeted CRISPR-Cas9 screening identifies core transcription factors controlling murine haemato-endothelial fate commitment.,2025,10.1038/s41467-025-66230-9,https://pubmed.ncbi.nlm.nih.gov/41390669/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,38306610,Rapid Generation of hPSC-Derived High Endothelial Venule Organoids with In Vivo Ectopic Lymphoid Tissue Capabilities.,2024,10.1002/adma.202308760,https://pubmed.ncbi.nlm.nih.gov/38306610/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,41708889,miR126-mediated alteration of vascular integrity in Rett syndrome.,2026,10.1038/s41380-026-03492-9,https://pubmed.ncbi.nlm.nih.gov/41708889/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,39922133,Transcriptome and chromatin accessibility landscape of ovarian development at different egg-laying stages in taihe black-bone silky fowls.,2025,10.1016/j.psj.2025.104864,https://pubmed.ncbi.nlm.nih.gov/39922133/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,37353106,LSD1 promotes the egress of hematopoietic stem and progenitor cells into the bloodstream during the endothelial-to-hematopoietic transition.,2023,10.1016/j.ydbio.2023.06.012,https://pubmed.ncbi.nlm.nih.gov/37353106/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ETV2,ENSG00000105672,Unsafe,40079219,The zebrafish ETS transcription factor Fli1b functions upstream of Scl/Tal1 during embryonic hematopoiesis.,2025,10.1242/bio.061948,https://pubmed.ncbi.nlm.nih.gov/40079219/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,42909385,EXO1 inhibition selectively kills replication repair-deficient cancer cells.,2026,10.1093/narcan/zcag029,https://pubmed.ncbi.nlm.nih.gov/42909385/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,42729530,A phenotype- and potency-gated extracellular vesicle allocation hypothesis for autism.,2026,10.3389/frcha.2026.1942419,https://pubmed.ncbi.nlm.nih.gov/42729530/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,42170255,Accelerating tumor evolution and enhancing immunotherapy efficacy in lung adenocarcinoma based on EXO1 inhibition.,2026,10.21037/tlcr-2025-1-1357,https://pubmed.ncbi.nlm.nih.gov/42170255/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,41741471,The nuclease EXO1 promotes genomic instability by degrading nascent DNA in BRCA-proficient cells.,2026,10.1038/s41467-026-69981-1,https://pubmed.ncbi.nlm.nih.gov/41741471/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,40074873,"EXO1's pan-cancer roles: diagnostic, prognostic, and immunological analyses through bioinformatics.",2025,10.1007/s12672-025-02045-w,https://pubmed.ncbi.nlm.nih.gov/40074873/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,40946999,Role of SIX5-mediated EXO1 overexpression in driving glioblastoma progression: Insights into tumor cell migration and angiogenesis.,2025,10.1016/j.brainres.2025.149930,https://pubmed.ncbi.nlm.nih.gov/40946999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,40433389,Deciphering the multifaceted role of &lt;i&gt;EXO1&lt;/i&gt; in female-related cancers: implications for prognosis and therapeutic responsiveness.,2025,10.3389/fimmu.2025.1591505,https://pubmed.ncbi.nlm.nih.gov/40433389/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,40530129,Construction and validation of a prognostic model for glioma: an analysis based on mismatch repair-related genes and their correlation with clinicopathological features.,2025,10.21037/tcr-24-2045,https://pubmed.ncbi.nlm.nih.gov/40530129/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,42830602,Redundant mispair excision mechanisms in eukaryotic DNA mismatch repair.,2026,10.1080/19491034.2026.2741514,https://pubmed.ncbi.nlm.nih.gov/42830602/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,41841497,Genome-wide CRISPR screens identify the EXO1-CAF-1 pathway suppressing R-loop-associated DNA damage.,2026,10.1093/nar/gkag226,https://pubmed.ncbi.nlm.nih.gov/41841497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,42792682,"BUB1 and CDK4/6 Dual Inhibition Increases Radiation Sensitivity in Glioblastoma, Lung Cancer, and Triple-Negative Breast Cancer.",2026,10.3390/biomedicines14091940,https://pubmed.ncbi.nlm.nih.gov/42792682/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,39893221,EXO1 is a key gene for lung-resident memory T cells and has diagnostic and predictive values for lung adenocarcinoma.,2025,10.1038/s41598-025-88126-w,https://pubmed.ncbi.nlm.nih.gov/39893221/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,42413327,Molecular effects of ovarian stimulation for fertility preservation in breast cancer: a paired-biopsy analysis.,2026,10.1016/j.esmoop.2026.108281,https://pubmed.ncbi.nlm.nih.gov/42413327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,42234659,Exploring hypoxia-related genes as prognostic indicators in lung adenocarcinoma.,2026,10.1371/journal.pone.0349820,https://pubmed.ncbi.nlm.nih.gov/42234659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,41323735,EXO1 overexpression induces homologous recombination deficiency and enhances PARP inhibitor sensitivity in ER-positive breast cancer: modulation by N4BP2L2-Mediated restoration.,2025,10.3389/fcell.2025.1695627,https://pubmed.ncbi.nlm.nih.gov/41323735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,42633728,Carbohydrate dynamics and transcriptomic changes during floral development in heterodichogamous Ziziphus jujuba.,2026,10.1016/j.plaphy.2026.111679,https://pubmed.ncbi.nlm.nih.gov/42633728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,39465585,Transcriptomic analysis of the gonads of Locusta migratoria (Orthoptera: Acrididae) following infection with Paranosema locustae.,2024,10.1017/s0007485324000592,https://pubmed.ncbi.nlm.nih.gov/39465585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,42564071,"Bacterial and gut microbiota-derived extracellular vesicles as emerging sources of cancer biomarkers: molecular mechanisms, diagnostic approaches, and therapeutic applications.",2026,10.3389/fcimb.2026.1806945,https://pubmed.ncbi.nlm.nih.gov/42564071/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,42314223,Response of MRC-5 human lung fibroblasts to FLASH and conventional radiotherapy: A study on differential DNA damage and transcriptomic response.,2026,10.1016/j.compbiolchem.2026.109198,https://pubmed.ncbi.nlm.nih.gov/42314223/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,39777332,The bioinformatics analysis and experimental validation of the carcinogenic role of EXO1 in lung adenocarcinoma.,2024,10.3389/fonc.2024.1492725,https://pubmed.ncbi.nlm.nih.gov/39777332/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,42914913,Earthworm-assisted enrichment of specific indigenous soil microbes for the preferential degradation of hexaconazole R-enantiomer.,2026,10.1016/j.jhazmat.2026.143986,https://pubmed.ncbi.nlm.nih.gov/42914913/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,40214853,"EXO1 as a potential biomarker for prognosis, immune infiltration, and immunotherapy in pan-cancer analysis.",2025,10.1007/s10142-025-01586-1,https://pubmed.ncbi.nlm.nih.gov/40214853/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,42219787,Computational Analysis of Differentially Expressed Genes in Arsenic-Induced Carcinogenesis and Their Effect on Human Repair Mechanisms.,2026,10.1002/em.70060,https://pubmed.ncbi.nlm.nih.gov/42219787/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,41310864,Molecular subtyping and a seven-gene immune signature reveal heterogeneity in tumor microenvironment and prognosis of lung adenocarcinoma.,2025,10.1186/s40001-025-03544-w,https://pubmed.ncbi.nlm.nih.gov/41310864/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,41642819,High-throughput analyses of a reconstituted diversity-generating retroelement identify intrinsic and extrinsic determinants of diversification.,2026,10.1371/journal.pgen.1012038,https://pubmed.ncbi.nlm.nih.gov/41642819/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,42273677,Identification of a novel PANoptosis-associated prognostic signature and immune landscape analysis in neuroblastoma with experimental validation.,2026,10.3389/fimmu.2026.1853357,https://pubmed.ncbi.nlm.nih.gov/42273677/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,39569972,Modification of Azo-Aminopyrimidines as Potent Multitarget Inhibitors of Insect Chitinolytic Enzymes OfChi-h and OfHex1.,2024,10.1021/acs.jafc.4c06797,https://pubmed.ncbi.nlm.nih.gov/39569972/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,10856833,Identification of factors interacting with hMSH2 in the fetal liver utilizing the yeast two-hybrid system. In vivo interaction through the C-terminal domains of hEXO1 and hMSH2 and comparative expression analysis.,2000,10.1016/s0921-8777(00)00012-4,https://pubmed.ncbi.nlm.nih.gov/10856833/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,9823303,"Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombination.",1998,,https://pubmed.ncbi.nlm.nih.gov/9823303/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,9788596,Human exonuclease I interacts with the mismatch repair protein hMSH2.,1998,,https://pubmed.ncbi.nlm.nih.gov/9788596/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
EXO1,ENSG00000174371,Unsafe,9685493,Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1.,1998,10.1093/nar/26.16.3762,https://pubmed.ncbi.nlm.nih.gov/9685493/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,41730960,"VPS13B, gene responsible for Cohen syndrome, regulates gingival epithelial barrier function via intracellular trafficking of coxsackievirus and adenovirus receptor.",2026,10.1038/s41598-026-40840-9,https://pubmed.ncbi.nlm.nih.gov/41730960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,42819782,"Brain endothelial homeostasis in psychiatric disorders: mechanisms, evidence, and translational opportunities.",2026,10.3389/fncel.2026.1901256,https://pubmed.ncbi.nlm.nih.gov/42819782/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,42242044,"Furosemide induces dose-dependent testicular toxicity via disrupting blood-testis barrier, inflammation, and apoptosis: A comprehensive biochemical, hormonal, and histopathological study.",2026,10.1016/j.tice.2026.103659,https://pubmed.ncbi.nlm.nih.gov/42242044/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,40881345,"&lt;i&gt;HAX1&lt;/i&gt;, gene responsible for Kostmann syndrome, regulates gingival epithelial barrier function via intracellular trafficking of JAM1.",2025,10.3389/fcell.2025.1624718,https://pubmed.ncbi.nlm.nih.gov/40881345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,41412328,MEG3 Promoter Methylation and F11 Receptor (F11R) Overexpression Define a High-Risk Subtype of Diabetic Pancreatic Cancer.,2026,10.1016/j.modpat.2025.100953,https://pubmed.ncbi.nlm.nih.gov/41412328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,42206057,Stress accelerates hepatocellular carcinoma progression via a gut microbial-metabolite axis.,2026,10.3389/fimmu.2026.1790214,https://pubmed.ncbi.nlm.nih.gov/42206057/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,42461884,12-HHT is associated with epithelial barrier enhancement and reduced inflammatory responses in colon organoids of normoganglionosis in Hirschsprung's disease.,2026,10.1371/journal.pone.0344140,https://pubmed.ncbi.nlm.nih.gov/42461884/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,42770193,Intestinal Epithelial-Protective Effects of &lt;i&gt;Leuconostoc mesenteroides&lt;/i&gt; H40 in LPS-Stimulated HT-29 Cells.,2026,10.4014/jmb.2607.07028,https://pubmed.ncbi.nlm.nih.gov/42770193/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,41058282,Downregulation of F11R in Colorectal Cancer and Tumour Progression.,2025,10.29271/jcpsp.2025.10.1269,https://pubmed.ncbi.nlm.nih.gov/41058282/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,42204384,Junctional Adhesion Molecule-A (JAM-A) Associates With High-Risk Disease in Multiple Myeloma Patients and a Structure-Based Rationally-Designed Peptide Inhibitor Attenuates Tumorigenic Features In Vitro and In Vivo.,2026,10.1111/ejh.70225,https://pubmed.ncbi.nlm.nih.gov/42204384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,40381037,3'UTR RNA editing driven by ADAR1 modulates MDM2 expression in breast cancer cells.,2025,10.1007/s10142-025-01611-3,https://pubmed.ncbi.nlm.nih.gov/40381037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,41616848,Ligand-receptor hotspots in dendritic-T cell niches expose targets in autoimmunity.,2026,10.1016/j.trsl.2026.01.006,https://pubmed.ncbi.nlm.nih.gov/41616848/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,42206911,Stage-specific biomarkers in triple-negative breast cancer: Preliminary findings from bioinformatics approaches.,2026,10.1177/18758592261454886,https://pubmed.ncbi.nlm.nih.gov/42206911/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,42467765,Mesenchymal stem cells receive adaptive islet-derived &lt;i&gt;miR-151&lt;/i&gt;-containing sEVs to promote β cell compensation in obesity.,2026,10.1126/sciadv.adu4196,https://pubmed.ncbi.nlm.nih.gov/42467765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,42637667,Identification of a novel high-prevalence red blood cell antigen on junctional adhesion molecule-A defines a new blood group system.,2026,10.1111/vox.70352,https://pubmed.ncbi.nlm.nih.gov/42637667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,39433915,"SLC37A4, gene responsible for glycogen storage disease type 1b, regulates gingival epithelial barrier function via JAM1 expression.",2024,10.1038/s41598-024-75524-9,https://pubmed.ncbi.nlm.nih.gov/39433915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,42483197,Proteomic profiling of single extracellular vesicles reveals association of CD31&lt;sup&gt;+&lt;/sup&gt; EV subpopulation with immune dysregulation in people living with HIV.,2026,10.3389/fimmu.2026.1871641,https://pubmed.ncbi.nlm.nih.gov/42483197/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,40132981,Homophilic Interactions of Platelet F11R/JAM-A with its Surface-Bound Counterpart Facilitate Thrombus Formation.,2026,10.1055/a-2565-9496,https://pubmed.ncbi.nlm.nih.gov/40132981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,40793975,F11r Deficiency-Mediated Disruption of Crosstalk Between Decidual Epithelial Cells and Macrophages is Detrimental to Female Pregnancy.,2025,10.1096/fj.202403397rr,https://pubmed.ncbi.nlm.nih.gov/40793975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,39129220,Plasma Olink Proteomics Reveals Novel Biomarkers for Prediction and Diagnosis in Dilated Cardiomyopathy with Heart Failure.,2024,10.1021/acs.jproteome.4c00522,https://pubmed.ncbi.nlm.nih.gov/39129220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,40128571,Unveiling the role of PPIF and macrophage subtypes in LSCC progression via single-cell and exosome RNA sequencing.,2025,10.1038/s41598-025-93584-3,https://pubmed.ncbi.nlm.nih.gov/40128571/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,39632279,Chromosome 1 Alterations in Multiple Myeloma: Considerations for Precision Therapy.,2025,10.1111/ejh.14352,https://pubmed.ncbi.nlm.nih.gov/39632279/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,41532082,"Ellagic acid mitigates rotavirus-induced intestinal injury via bidirectional ""immune-microbiota"" regulatory effect.",2025,10.3389/fcimb.2025.1686918,https://pubmed.ncbi.nlm.nih.gov/41532082/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,39061997,Identification and Validation of JAM-A as a Novel Prognostic and Immune Factor in Human Tumors.,2024,10.3390/biomedicines12071423,https://pubmed.ncbi.nlm.nih.gov/39061997/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,41356186,MAP3K3 Contributes to Myocardial Ischemia/Reperfusion Injury by Promoting Myeloid Cell Diapedesis through TAL1/JAM-A Pathway.,2026,10.7150/thno.122130,https://pubmed.ncbi.nlm.nih.gov/41356186/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,37563645,Triple negative breast cancer metastasis is hindered by a peptide antagonist of F11R/JAM‑A protein.,2023,10.1186/s12935-023-03023-4,https://pubmed.ncbi.nlm.nih.gov/37563645/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,41680500,Protein networks are influenced by maternal BMI and differentiate preterm birth types.,2026,10.1038/s43856-026-01376-1,https://pubmed.ncbi.nlm.nih.gov/41680500/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,34533648,The F11 Receptor (F11R)/Junctional Adhesion Molecule-A (JAM-A) (F11R/JAM-A) in cancer progression.,2022,10.1007/s11010-021-04259-2,https://pubmed.ncbi.nlm.nih.gov/34533648/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,41147554,[Identification of human genes potentially involved in the pathogenesis of viral hepatitis C based on multi-network bioinformatics analysis].,2025,10.36233/0507-4088-314,https://pubmed.ncbi.nlm.nih.gov/41147554/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,39348809,Identification of Immune-Related Genes as Potential Biomarkers in Early Septic Shock.,2025,10.1159/000540949,https://pubmed.ncbi.nlm.nih.gov/39348809/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,40808866,Identifying inflammatory bowel disease subtypes: a comprehensive exploration of transcriptomic data and machine learning-based approaches.,2025,10.1177/17562848251362391,https://pubmed.ncbi.nlm.nih.gov/40808866/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,35402226,The Long Non-Coding RNA HOXC-AS3 Promotes Glioma Progression by Sponging miR-216 to Regulate F11R Expression.,2022,10.3389/fonc.2022.845009,https://pubmed.ncbi.nlm.nih.gov/35402226/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F11R,ENSG00000158769,Unsafe,11812992,JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes.,2002,10.1038/ni755,https://pubmed.ncbi.nlm.nih.gov/11812992/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,42525541,A screen for adherens junction proteins regulating collective cell migration and testis morphogenesis reveals important roles for the Rab GAP RN-tre and the kinase Par-1.,2026,10.1091/mbc.e26-05-0234,https://pubmed.ncbi.nlm.nih.gov/42525541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,40626835,The polarity protein Par3 enhances renal cell carcinoma metastasis &lt;i&gt;via&lt;/i&gt; YAP/TAZ activation.,2025,10.20892/j.issn.2095-3941.2024.0297,https://pubmed.ncbi.nlm.nih.gov/40626835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,41559805,Polarity protein Par3 deficiency promotes metastasis of bladder cancer via interaction of Ppp1r12c.,2026,10.1186/s13062-026-00727-1,https://pubmed.ncbi.nlm.nih.gov/41559805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,41274508,Polarity protein Par3L deletion causes chromosomal segregation defects and tumorigenesis.,2026,10.1016/j.jbc.2025.110966,https://pubmed.ncbi.nlm.nih.gov/41274508/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,42541493,Breast Cancer-Derived AZU1 Educates Neutrophils to Promote Tumor Progression and Metastasis Through PAD4-Dependent Extracellular Trap Formation.,2026,10.1002/mc.70159,https://pubmed.ncbi.nlm.nih.gov/42541493/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,41478470,RASSF9: A modulator of PAR3 condensates in polarity signaling.,2026,10.1016/j.ijbiomac.2025.149965,https://pubmed.ncbi.nlm.nih.gov/41478470/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,41339651,Integrated profiling reveals polarity protein dysregulation during oral cancer progression.,2025,10.1038/s41598-025-27447-2,https://pubmed.ncbi.nlm.nih.gov/41339651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,40750003,Reduced microRNA-5572 in thyroid eye disease orbital fibroblasts promotes fibrosis by targeting F2RL2.,2025,10.1016/j.exer.2025.110565,https://pubmed.ncbi.nlm.nih.gov/40750003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,42285921,"PAR3-mediated coordination of hepatocyte proliferation, maturation, and architecture in liver development and regeneration.",2026,10.1038/s41467-026-73856-w,https://pubmed.ncbi.nlm.nih.gov/42285921/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,41616029,Application of the Er:YAG laser in pulpotomy for mature permanent teeth with pulpitis: An animal study.,2026,10.1371/journal.pone.0341017,https://pubmed.ncbi.nlm.nih.gov/41616029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,40766339,The protease-activated receptors are expressed in glioblastoma and differentially modulate adherent versus stem-like growth of LN-18 GBM cells.,2025,10.3389/fonc.2025.1582996,https://pubmed.ncbi.nlm.nih.gov/40766339/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,41566508,IIIG9 and PP1α form a protein complex in the adherens junctions of polarized ependymal and MDCK cells.,2026,10.1186/s12987-026-00762-0,https://pubmed.ncbi.nlm.nih.gov/41566508/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,39700430,aPKC/Par3/Par6 polarity complexes regulate podocyte motility and crescent formation in the progression of ANCA-associated vasculitis.,2025,10.1093/rheumatology/keae700,https://pubmed.ncbi.nlm.nih.gov/39700430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,42784876,Machine learning identification of biomarkers for vascular endothelial damage in obstructive sleep apnea.,2026,10.1016/j.clinsp.2026.101165,https://pubmed.ncbi.nlm.nih.gov/42784876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,42007152,A novel prognostic signature based on epithelial-mesenchymal transition-associated genes for the prognosis and immune status in breast cancer.,2026,10.62347/jqqx7009,https://pubmed.ncbi.nlm.nih.gov/42007152/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,42708509,Centrosome migration and apical membrane formation during epithelial polarization in MDCK cysts.,2026,10.7554/elife.101088,https://pubmed.ncbi.nlm.nih.gov/42708509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,39128653,BET Inhibition Rescues Acinar-Ductal-Metaplasia and Ciliogenesis and Ameliorates Chronic Pancreatitis-Driven Changes in Mice With Loss of the Polarity Protein Par3.,2024,10.1016/j.jcmgh.2024.101389,https://pubmed.ncbi.nlm.nih.gov/39128653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,39869832,Protection of β2GPI-deficient mice from thrombosis reflects a defect in PAR3-facilitated platelet activation.,2025,10.1182/blood.2024024469,https://pubmed.ncbi.nlm.nih.gov/39869832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,40740562,Identification of Prognostic and Diagnostic Biomarkers for Glioma Utilizing Immune System Gene Profiling.,2025,10.47176/mjiri.39.49,https://pubmed.ncbi.nlm.nih.gov/40740562/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,41315260,Deciphering the role of complement system genes in pancreatic cancer susceptibility and prognosis.,2025,10.1038/s41467-025-65811-y,https://pubmed.ncbi.nlm.nih.gov/41315260/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,40777024,Identification of a coagulation-related classification and signature that predict disease heterogeneity for colorectal cancer and pan-cancer patients.,2025,10.3389/fimmu.2025.1572701,https://pubmed.ncbi.nlm.nih.gov/40777024/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,40224973,Identification of novel neutrophil-extracellular-traps-related genes as biomarkers for breast cancer prognosis and immunotherapy.,2025,10.21037/tcr-24-1826,https://pubmed.ncbi.nlm.nih.gov/40224973/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,39045101,Loss of the polarity protein Par3 promotes dendritic spine neoteny and enhances learning and memory.,2024,10.1016/j.isci.2024.110308,https://pubmed.ncbi.nlm.nih.gov/39045101/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,37939567,Identification of novel NRF2-dependent genes as regulators of lead and arsenic toxicity in neural progenitor cells.,2024,10.1016/j.jhazmat.2023.132906,https://pubmed.ncbi.nlm.nih.gov/37939567/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,38588631,Identification and validation of regulatory T cell-associated gene signatures to predict colon adenocarcinoma prognosis.,2024,10.1016/j.intimp.2024.112034,https://pubmed.ncbi.nlm.nih.gov/38588631/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,36588538,Identification of an Immune-Related Gene Signature Associated with Prognosis and Tumor Microenvironment in Esophageal Cancer.,2022,10.1155/2022/7413535,https://pubmed.ncbi.nlm.nih.gov/36588538/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,41665817,Mast Cell Chymase and Human Lung Fibroblast Interaction: Mechanisms and Implications for Asthma.,2026,10.1007/s10753-026-02460-3,https://pubmed.ncbi.nlm.nih.gov/41665817/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,38589651,A missense mutation in human INSC causes peripheral neuropathy.,2024,10.1038/s44321-024-00062-w,https://pubmed.ncbi.nlm.nih.gov/38589651/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,38479138,"Impact of fine particulate matter on liver injury: evidence from human, mice and cells.",2024,10.1016/j.jhazmat.2024.133958,https://pubmed.ncbi.nlm.nih.gov/38479138/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,40252157,ADAMTSL2 is an independent predictor for the prognosis of gastric cancer.,2025,10.1007/s12672-025-02259-y,https://pubmed.ncbi.nlm.nih.gov/40252157/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,37838223,Stem cell-derived paracrine factors by modulated reactive oxygen species to enhance cancer immunotherapy.,2023,10.1016/j.jconrel.2023.10.011,https://pubmed.ncbi.nlm.nih.gov/37838223/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,35875120,Dual Function of Par3 in Tumorigenesis.,2022,10.3389/fonc.2022.915957,https://pubmed.ncbi.nlm.nih.gov/35875120/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,37635877,Nox1-based NADPH oxidase regulates the Par protein complex activity to control cell polarization.,2023,10.3389/fcell.2023.1231489,https://pubmed.ncbi.nlm.nih.gov/37635877/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,36105107,Identification of hub genes related to CD4+ memory T cell infiltration with gene co-expression network predicts prognosis and immunotherapy effect in colon adenocarcinoma.,2022,10.3389/fgene.2022.915282,https://pubmed.ncbi.nlm.nih.gov/36105107/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,36221049,Novel six-gene prognostic signature based on colon adenocarcinoma immune-related genes.,2022,10.1186/s12859-022-04909-2,https://pubmed.ncbi.nlm.nih.gov/36221049/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,33931921,"Loss of polarity protein Par3, via transcription factor Snail, promotes bladder cancer metastasis.",2021,10.1111/cas.14920,https://pubmed.ncbi.nlm.nih.gov/33931921/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
F2RL2,ENSG00000164220,Unsafe,9614115,The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization in vascular endothelial cells and platelets.,1998,10.1074/jbc.273.24.15061,https://pubmed.ncbi.nlm.nih.gov/9614115/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FABP12,ENSG00000197416,Unsafe,40717587,Fatty acid-binding proteins in cancers.,2025,10.1097/js9.0000000000003049,https://pubmed.ncbi.nlm.nih.gov/40717587/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FABP12,ENSG00000197416,Unsafe,40324257,Exploring the causal association between fatty acid-binding proteins and anaphylactic shock due to adverse reactions to medications: A two-sample Mendelian randomization study.,2025,10.1097/md.0000000000042171,https://pubmed.ncbi.nlm.nih.gov/40324257/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FABP12,ENSG00000197416,Unsafe,39273616,Docetaxel-Induced Cell Death Is Regulated by a Fatty Acid-Binding Protein 12-Slug-Survivin Pathway in Prostate Cancer Cells.,2024,10.3390/ijms25179669,https://pubmed.ncbi.nlm.nih.gov/39273616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FABP12,ENSG00000197416,Unsafe,40890473,Fatty acid-binding proteins as potential biomarkers for human cancer prognosis.,2025,10.1038/s41598-025-17992-1,https://pubmed.ncbi.nlm.nih.gov/40890473/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FABP12,ENSG00000197416,Unsafe,33031638,The FABP12/PPARγ pathway promotes metastatic transformation by inducing epithelial-to-mesenchymal transition and lipid-derived energy production in prostate cancer cells.,2020,10.1002/1878-0261.12818,https://pubmed.ncbi.nlm.nih.gov/33031638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FABP12,ENSG00000197416,Unsafe,38292656,Fatty acid binding protein 5 is a novel therapeutic target for hepatocellular carcinoma.,2024,10.5306/wjco.v15.i1.130,https://pubmed.ncbi.nlm.nih.gov/38292656/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FABP12,ENSG00000197416,Unsafe,34680577,Expression Profiles and Prognostic Value of FABPs in Colorectal Adenocarcinomas.,2021,10.3390/biomedicines9101460,https://pubmed.ncbi.nlm.nih.gov/34680577/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FABP12,ENSG00000197416,Unsafe,37454837,Influence of dietary bioactive compounds on the bioavailability and excretion of PFOA and its alternative HFPO-TA: Mechanism exploration.,2023,10.1016/j.scitotenv.2023.165560,https://pubmed.ncbi.nlm.nih.gov/37454837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FABP12,ENSG00000197416,Unsafe,33035272,Hypolipidemic effect of Alisma orientale (Sam.) Juzep on gut microecology and liver transcriptome in diabetic rats.,2020,10.1371/journal.pone.0240616,https://pubmed.ncbi.nlm.nih.gov/33035272/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FABP12,ENSG00000197416,Unsafe,18786628,A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis.,2008,10.1016/j.ygeno.2008.08.003,https://pubmed.ncbi.nlm.nih.gov/18786628/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FABP12,ENSG00000197416,Unsafe,21504868,The human fatty acid-binding protein family: evolutionary divergences and functions.,2011,10.1186/1479-7364-5-3-170,https://pubmed.ncbi.nlm.nih.gov/21504868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FABP12,ENSG00000197416,Unsafe,23962454,"Cell-type-specific regulation of genes involved in testicular lipid metabolism: fatty acid-binding proteins, diacylglycerol acyltransferases, and perilipin 2.",2013,10.1530/rep-13-0199,https://pubmed.ncbi.nlm.nih.gov/23962454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FABP12,ENSG00000197416,Unsafe,26644202,Common variants associated with changes in levels of circulating free fatty acids after administration of glucose-insulin-potassium (GIK) therapy in the IMMEDIATE trial.,2017,10.1038/tpj.2015.84,https://pubmed.ncbi.nlm.nih.gov/26644202/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,42228561,Faf1 accelerates p97-mediated protein unfolding by promoting ubiquitin engagement.,2026,10.1016/j.celrep.2026.117393,https://pubmed.ncbi.nlm.nih.gov/42228561/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,42067912,A non-complement role for C1R rewires integrin and death-receptor signaling to drive renal cancer metastasis.,2026,10.1186/s12943-026-02677-8,https://pubmed.ncbi.nlm.nih.gov/42067912/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,41790892,"The accessory adapters FAF1, FAF2, and UBXN7 accelerate proteasomal degradation by increasing prior p97-mediated substrate unfolding.",2026,10.1126/sciadv.aea7381,https://pubmed.ncbi.nlm.nih.gov/41790892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,36766229,Expression and Localization of Fas-Associated Factor 1 in Testicular Tissues of Different Ages and Ovaries at Different Reproductive Cycle Phases of Bos grunniens.,2023,10.3390/ani13030340,https://pubmed.ncbi.nlm.nih.gov/36766229/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,39881045,Evaluation of the role of circular RNA (circ-FAF1) as a diagnostic biomarker for breast cancer in a cohort of Egyptian breast cancer patients.,2025,10.1007/s11033-024-10210-7,https://pubmed.ncbi.nlm.nih.gov/39881045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,41294004,Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC).,2025,10.7554/elife.101496,https://pubmed.ncbi.nlm.nih.gov/41294004/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,42603836,FAF1 and FAF2 enhance unfolding by p97-UFD1-NPL4 complex enabling rational design of p97 activators.,2026,10.1038/s44318-026-00894-x,https://pubmed.ncbi.nlm.nih.gov/42603836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,39793039,VCP controls KCC2 degradation through FAF1 recruitment and accelerates emergence from anesthesia.,2025,10.1073/pnas.2414016122,https://pubmed.ncbi.nlm.nih.gov/39793039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,37999107,High Expression of Fas-Associated Factor 1 Indicates a Poor Prognosis in Non-Small-Cell Lung Cancer.,2023,10.3390/curroncol30110687,https://pubmed.ncbi.nlm.nih.gov/37999107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,42805974,Risk of drug-induced liver injury in multiple system atrophy patients treated with KM-819 is potentially associated with the HLA-DPB1*05:01:01:01 allele.,2026,10.1038/s41397-026-00431-3,https://pubmed.ncbi.nlm.nih.gov/42805974/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,38172660,Sumoylation of SAP130 regulates its interaction with FAF1 as well as its protein stability and transcriptional repressor function.,2024,10.1186/s12860-023-00498-x,https://pubmed.ncbi.nlm.nih.gov/38172660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,41633774,eRNAs modulate mRNA stability and translation efficiency to bridge transcriptional and post-transcriptional gene regulation.,2026,10.1261/rna.080681.125,https://pubmed.ncbi.nlm.nih.gov/41633774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,40614258,Caspar modulates primordial germ cell fate both in an Oskar-dependent and Oskar-independent manner.,2025,10.1242/bio.062119,https://pubmed.ncbi.nlm.nih.gov/40614258/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,38578382,Inhibition of circ_0073932 attenuates myocardial ischemia‒reperfusion injury via miR-493-3p/FAF1/JNK.,2024,10.1007/s11626-024-00900-8,https://pubmed.ncbi.nlm.nih.gov/38578382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,35704671,The complex of Fas-associated factor 1 with Hsp70 stabilizes the adherens junction integrity by suppressing RhoA activation.,2022,10.1093/jmcb/mjac037,https://pubmed.ncbi.nlm.nih.gov/35704671/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,38065537,FAF1 Gene Involvement in Pituitary Corticotroph Tumors.,2024,10.1055/a-2192-1761,https://pubmed.ncbi.nlm.nih.gov/38065537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,39862324,Identification of Novel Biomarkers for Ischemic Stroke Through Integrated Bioinformatics Analysis and Machine Learning.,2025,10.1007/s12031-025-02309-8,https://pubmed.ncbi.nlm.nih.gov/39862324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,37929693,EARLY FLOWERING is a dominant gain-of-function allele of FANTASTIC FOUR 1/2c that promotes early flowering in tomato.,2024,10.1111/pbi.14217,https://pubmed.ncbi.nlm.nih.gov/37929693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,41910647,Prolonged Mild Sleep Restriction Changes Epigenome-Wide DNA Methylation in Peripheral Blood Cells: A Randomized Crossover Trial.,2026,10.14336/ad.2025.1261,https://pubmed.ncbi.nlm.nih.gov/41910647/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,38031027,"Identification of copy neutral loss of heterozygosity on chromosomes 1p, 1q, and 6p among nonsyndromic cleft lip and/or without cleft palate with hypodontia.",2023,10.1186/s12903-023-03464-3,https://pubmed.ncbi.nlm.nih.gov/38031027/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,38365777,"Exploring the role of ubiquitin regulatory X domain family proteins in cancers: bioinformatics insights, mechanisms, and implications for therapy.",2024,10.1186/s12967-024-04890-9,https://pubmed.ncbi.nlm.nih.gov/38365777/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,40356929,Mystery machine: the complex roles of NLRX1 in viral infection.,2025,10.3389/fimmu.2025.1581313,https://pubmed.ncbi.nlm.nih.gov/40356929/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,38474516,"Rat Pharmacokinetics and In Vitro Metabolite Identification of KM-819, a Parkinson's Disease Candidate, Using LC-MS/MS and LC-HRMS.",2024,10.3390/molecules29051004,https://pubmed.ncbi.nlm.nih.gov/38474516/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,38770398,Chorioretinal Atrophic Lesions Evolution in Patients with Quiescent Myopic Choroidal Neovascularization Followed for More Than 10 Years.,2024,10.2147/opth.s461515,https://pubmed.ncbi.nlm.nih.gov/38770398/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,34644576,USP7 and VCP&lt;sup&gt;FAF1&lt;/sup&gt; define the SUMO/Ubiquitin landscape at the DNA replication fork.,2021,10.1016/j.celrep.2021.109819,https://pubmed.ncbi.nlm.nih.gov/34644576/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,32831099,"A novel function of FAF1, which induces dopaminergic neuronal death through cell-to-cell transmission.",2020,10.1186/s12964-020-00632-8,https://pubmed.ncbi.nlm.nih.gov/32831099/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,37240373,Parkin Precipitates on Mitochondria via Aggregation and Autoubiquitination.,2023,10.3390/ijms24109027,https://pubmed.ncbi.nlm.nih.gov/37240373/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,35446841,A locus conferring tolerance to Theileria infection in African cattle.,2022,10.1371/journal.pgen.1010099,https://pubmed.ncbi.nlm.nih.gov/35446841/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,38911262,Analysis of 206 whole-genome resequencing reveals selection signatures associated with breed-specific traits in Hu sheep.,2024,10.1111/eva.13697,https://pubmed.ncbi.nlm.nih.gov/38911262/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,31412082,Fas-associated factor 1 mediates NADPH oxidase-induced reactive oxygen species production and proinflammatory responses in macrophages against Listeria infection.,2019,10.1371/journal.ppat.1008004,https://pubmed.ncbi.nlm.nih.gov/31412082/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,35377453,"Caspar, an adapter for VAPB and TER94, modulates the progression of ALS8 by regulating IMD/NFκB-mediated glial inflammation in a Drosophila model of human disease.",2022,10.1093/hmg/ddac076,https://pubmed.ncbi.nlm.nih.gov/35377453/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,36234935,Torularhodin Alleviates Hepatic Dyslipidemia and Inflammations in High-Fat Diet-Induced Obese Mice via PPARα Signaling Pathway.,2022,10.3390/molecules27196398,https://pubmed.ncbi.nlm.nih.gov/36234935/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,27664323,"Subacute toxicity evaluation of KR-33493, FAF1 inhibitor for a new anti-parkinson's disease agent, after oral administration in rats and dogs.",2016,10.1016/j.yrtph.2016.09.022,https://pubmed.ncbi.nlm.nih.gov/27664323/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,31731522,Transcriptome Profile Alteration with Cadmium Selenide/Zinc Sulfide Quantum Dots in Saccharomyces cerevisiae.,2019,10.3390/biom9110653,https://pubmed.ncbi.nlm.nih.gov/31731522/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,32676027,Neurorestorative Effects of a Novel Fas-Associated Factor 1 Inhibitor in the MPTP Model: An [18F]FE-PE2I Positron Emission Tomography Analysis Study.,2020,10.3389/fphar.2020.00953,https://pubmed.ncbi.nlm.nih.gov/32676027/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,26811330,Fas-Associated Factor 1 Negatively Regulates the Antiviral Immune Response by Inhibiting Translocation of Interferon Regulatory Factor 3 to the Nucleus.,2016,10.1128/mcb.00744-15,https://pubmed.ncbi.nlm.nih.gov/26811330/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,30992659,"A first-in-human study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of KM-819 (FAS-associated factor 1 inhibitor), a drug for Parkinson's disease, in healthy volunteers.",2019,10.2147/dddt.s198753,https://pubmed.ncbi.nlm.nih.gov/30992659/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAF1,ENSG00000185104,Unsafe,10462485,"Identification and characterization of human Fas associated factor 1, hFAF1.",1999,10.1006/bbrc.1999.1217,https://pubmed.ncbi.nlm.nih.gov/10462485/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,40814172,FAHD1-mediated pyruvate metabolism in hepatocellular carcinoma: Multi-omics and causal genetic evidence.,2025,10.1016/j.xhgg.2025.100494,https://pubmed.ncbi.nlm.nih.gov/40814172/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,41041519,FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS-STING pathway.,2025,10.1515/med-2025-1200,https://pubmed.ncbi.nlm.nih.gov/41041519/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,41286267,Catalytic activity of FAHD1 correlates with nuclear morphology and proteomic states in human osteosarcoma cells.,2025,10.1038/s41598-025-29460-x,https://pubmed.ncbi.nlm.nih.gov/41286267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,39642098,FAHD1 and mitochondrial metabolism: a decade of pioneering discoveries.,2025,10.1111/febs.17345,https://pubmed.ncbi.nlm.nih.gov/39642098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,38649439,Mitochondrial enzyme FAHD1 reduces ROS in osteosarcoma.,2024,10.1038/s41598-024-60012-x,https://pubmed.ncbi.nlm.nih.gov/38649439/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,39741754,Single-Cell and Transcriptome Analysis of Periodontitis: Molecular Subtypes and Biomarkers Linked to Mitochondrial Dysfunction and Immunity.,2024,10.2147/jir.s498739,https://pubmed.ncbi.nlm.nih.gov/39741754/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,40316856,Integrating analysis of multi-omics summary data identifies novel plasma protein biomarkers and drug targets for bladder cancer.,2025,10.1007/s12672-025-02476-5,https://pubmed.ncbi.nlm.nih.gov/40316856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,41831914,Root inoculation with Trichoderma harzianum primes metabolic and stress-response pathways underlying growth and resistance in Brassica rapa.,2026,10.1016/j.pestbp.2026.107053,https://pubmed.ncbi.nlm.nih.gov/41831914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,35962472,The mitochondrial enzyme FAHD1 regulates complex II activity in breast cancer cells and is indispensable for basal BT-20 cells in vitro.,2022,10.1002/1873-3468.14462,https://pubmed.ncbi.nlm.nih.gov/35962472/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,39202427,DNA Methylation of Postnatal Liver Development in Pigs.,2024,10.3390/genes15081067,https://pubmed.ncbi.nlm.nih.gov/39202427/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,34440809,High Glycolytic Activity Enhances Stem Cell Reprogramming of Fahd1-KO Mouse Embryonic Fibroblasts.,2021,10.3390/cells10082040,https://pubmed.ncbi.nlm.nih.gov/34440809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,32068790,Structural and functional comparison of fumarylacetoacetate domain containing protein 1 in human and mouse.,2020,10.1042/bsr20194431,https://pubmed.ncbi.nlm.nih.gov/32068790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,35253790,Extraction and Purification of FAHD1 Protein from Swine Kidney and Mouse Liver.,2022,10.3791/63333,https://pubmed.ncbi.nlm.nih.gov/35253790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,38047707,Bacillus subtilis YisK possesses oxaloacetate decarboxylase activity and exhibits Mbl-dependent localization.,2024,10.1128/jb.00202-23,https://pubmed.ncbi.nlm.nih.gov/38047707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,34443596,Inhibitors of Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1).,2021,10.3390/molecules26165009,https://pubmed.ncbi.nlm.nih.gov/34443596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,32574647,Regulation of cellular senescence by eukaryotic members of the FAH superfamily - A role in calcium homeostasis?,2020,10.1016/j.mad.2020.111284,https://pubmed.ncbi.nlm.nih.gov/32574647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,31412049,Modulation of serotonin signaling by the putative oxaloacetate decarboxylase FAHD-1 in Caenorhabditis elegans.,2019,10.1371/journal.pone.0220434,https://pubmed.ncbi.nlm.nih.gov/31412049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,30055189,Oxaloacetate decarboxylase FAHD1 - a new regulator of mitochondrial function and senescence.,2019,10.1016/j.mad.2018.07.007,https://pubmed.ncbi.nlm.nih.gov/30055189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,30348641,Structural basis for the bi-functionality of human oxaloacetate decarboxylase FAHD1.,2018,10.1042/bcj20180750,https://pubmed.ncbi.nlm.nih.gov/30348641/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,31282888,"Expression, Purification, Crystallization, and Enzyme Assays of Fumarylacetoacetate Hydrolase Domain-Containing Proteins.",2019,10.3791/59729,https://pubmed.ncbi.nlm.nih.gov/31282888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,31231467,Prioritization of metabolic genes as novel therapeutic targets in estrogen-receptor negative breast tumors using multi-omics data and text mining.,2019,10.18632/oncotarget.26995,https://pubmed.ncbi.nlm.nih.gov/31231467/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,20705418,Fine mapping and expression of candidate genes within the chromosome 10 QTL region of the high and low alcohol-drinking rats.,2010,10.1016/j.alcohol.2010.06.004,https://pubmed.ncbi.nlm.nih.gov/20705418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAHD1,ENSG00000180185,Unsafe,21878618,Identification of human fumarylacetoacetate hydrolase domain-containing protein 1 (FAHD1) as a novel mitochondrial acylpyruvase.,2011,10.1074/jbc.m111.264770,https://pubmed.ncbi.nlm.nih.gov/21878618/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM118B,ENSG00000197798,Unsafe,41863510,FAM118B Promotes Colorectal Carcinogenesis Through a Novel Mechanism Involving Enhanced RelA Transactivation and Subsequent SELENOF-Dependent Glycolytic Activity.,2026,10.1096/fj.202504389r,https://pubmed.ncbi.nlm.nih.gov/41863510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM118B,ENSG00000197798,Unsafe,41249820,Filament formation and NAD processing by noncanonical human FAM118 sirtuins.,2025,10.1038/s41594-025-01715-1,https://pubmed.ncbi.nlm.nih.gov/41249820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM118B,ENSG00000197798,Unsafe,39301650,Low-grade glial/glioneuronal tumor with YAP1::FAM118B fusion: A novel molecular finding.,2025,10.1093/jnen/nlae103,https://pubmed.ncbi.nlm.nih.gov/39301650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM118B,ENSG00000197798,Unsafe,41511336,"An Exceptionally Complex Chromosome Rearrangement in the Great Tit &lt;i&gt;(Parus major)&lt;/i&gt;: Genetic Composition, Meiotic Behavior and Population Frequency.",2025,10.3390/cells15010052,https://pubmed.ncbi.nlm.nih.gov/41511336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM118B,ENSG00000197798,Unsafe,37929446,"C11orf95-RELA, YAP1-MAMLD1, and YAP1-FAM118B Fusion Negative Anaplastic Ependymoma with Lipogenic Differentiation.",2023,10.4103/0028-3886.388099,https://pubmed.ncbi.nlm.nih.gov/37929446/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM118B,ENSG00000197798,Unsafe,33074854,YAP1-FAM118B Fusion Defines a Rare Subset of Childhood and Young Adulthood Meningiomas.,2021,10.1097/pas.0000000000001597,https://pubmed.ncbi.nlm.nih.gov/33074854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM118B,ENSG00000197798,Unsafe,33228790,Phenotypic characterization with somatic genome editing and gene transfer reveals the diverse oncogenicity of ependymoma fusion genes.,2020,10.1186/s40478-020-01080-8,https://pubmed.ncbi.nlm.nih.gov/33228790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM118B,ENSG00000197798,Unsafe,32675324,Comparison of tumor-associated YAP1 fusions identifies a recurrent set of functions critical for oncogenesis.,2020,10.1101/gad.338681.120,https://pubmed.ncbi.nlm.nih.gov/32675324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM118B,ENSG00000197798,Unsafe,37272434,[Verification of the diagnosis of supratentorial ependymomas by real-time PCR].,2023,10.17116/patol2023850315,https://pubmed.ncbi.nlm.nih.gov/37272434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM118B,ENSG00000197798,Unsafe,24569877,"Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability.",2014,10.1242/jcs.143453,https://pubmed.ncbi.nlm.nih.gov/24569877/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM118B,ENSG00000197798,Unsafe,33903940,A coordinated approach for the assessment of molecular subgroups in pediatric ependymomas using low-cost methods.,2021,10.1007/s00109-021-02074-2,https://pubmed.ncbi.nlm.nih.gov/33903940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM118B,ENSG00000197798,Unsafe,29354850,C11orf95-RELA fusions and upregulated NF-KB signalling characterise a subset of aggressive supratentorial ependymomas that express L1CAM and nestin.,2018,10.1007/s11060-018-2767-y,https://pubmed.ncbi.nlm.nih.gov/29354850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM133A,ENSG00000179083,Unsafe,37222076,Chemical features of melanoma tumor resident TRG CDR3s associated with better survival probabilities.,2023,10.1097/cmr.0000000000000899,https://pubmed.ncbi.nlm.nih.gov/37222076/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM133A,ENSG00000179083,Unsafe,35677036,Recurrence- and Malignant Progression-Associated Biomarkers in Low-Grade Gliomas and Their Roles in Immunotherapy.,2022,10.3389/fimmu.2022.899710,https://pubmed.ncbi.nlm.nih.gov/35677036/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM133A,ENSG00000179083,Unsafe,36110952,An emerging prognosis prediction model for multiple myeloma: Hypoxia-immune related microenvironmental gene signature.,2022,10.3389/fonc.2022.992387,https://pubmed.ncbi.nlm.nih.gov/36110952/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM133A,ENSG00000179083,Unsafe,29885519,Methylation-mediated miR-155-FAM133A axis contributes to the attenuated invasion and migration of IDH mutant gliomas.,2018,10.1016/j.canlet.2018.06.007,https://pubmed.ncbi.nlm.nih.gov/29885519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM133A,ENSG00000179083,Unsafe,34567094,Integrating Genetic and Transcriptomic Data to Reveal Pathogenesis and Prognostic Markers of Pancreatic Adenocarcinoma.,2021,10.3389/fgene.2021.747270,https://pubmed.ncbi.nlm.nih.gov/34567094/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM133A,ENSG00000179083,Unsafe,31960101,Associations between catechol-O-methyltransferase (COMT) genotypes at rs4818 and rs4680 and gene expression in human dorsolateral prefrontal cortex.,2020,10.1007/s00221-020-05730-0,https://pubmed.ncbi.nlm.nih.gov/31960101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM133A,ENSG00000179083,Unsafe,34108992,Multi-Omics Data Analyses Construct a Six Immune-Related Genes Prognostic Model for Cervical Cancer in Tumor Microenvironment.,2021,10.3389/fgene.2021.663617,https://pubmed.ncbi.nlm.nih.gov/34108992/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM133A,ENSG00000179083,Unsafe,32922554,Clinical significance of long non-coding RNA DUXAP8 and its protein coding genes in hepatocellular carcinoma.,2020,10.7150/jca.47902,https://pubmed.ncbi.nlm.nih.gov/32922554/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM133A,ENSG00000179083,Unsafe,30278442,The Profile of Genetic Mutations in Papillary Thyroid Cancer Detected by Whole Exome Sequencing.,2018,10.1159/000493966,https://pubmed.ncbi.nlm.nih.gov/30278442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM133A,ENSG00000179083,Unsafe,27321945,Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.,2016,10.1016/j.ajhg.2016.05.006,https://pubmed.ncbi.nlm.nih.gov/27321945/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,42009625,Unusual presentation of cone dysfunction consequent upon a homozygous &lt;i&gt;FAM161A&lt;/i&gt; variant.,2026,10.1080/13816810.2026.2653146,https://pubmed.ncbi.nlm.nih.gov/42009625/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,38504136,Fine-tuning FAM161A gene augmentation therapy to restore retinal function.,2024,10.1038/s44321-024-00053-x,https://pubmed.ncbi.nlm.nih.gov/38504136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,37580905,Gene augmentation therapy attenuates retinal degeneration in a knockout mouse model of Fam161a retinitis pigmentosa.,2023,10.1016/j.ymthe.2023.08.011,https://pubmed.ncbi.nlm.nih.gov/37580905/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,39062732,Exonic Short Interspersed Nuclear Element Insertion in FAM161A Is Associated with Autosomal Recessive Progressive Retinal Atrophy in the English Shepherd.,2024,10.3390/genes15070952,https://pubmed.ncbi.nlm.nih.gov/39062732/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,38168044,The evolution of centriole degradation in mouse sperm.,2024,10.1038/s41467-023-44411-8,https://pubmed.ncbi.nlm.nih.gov/38168044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,39255847,Fly Fam161 is an essential centriole and cilium transition zone protein with unique and diverse cell type-specific localizations.,2024,10.1098/rsob.240036,https://pubmed.ncbi.nlm.nih.gov/39255847/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,39451224,A Comparative Analysis of Models for AAV-Mediated Gene Therapy for Inherited Retinal Diseases.,2024,10.3390/cells13201706,https://pubmed.ncbi.nlm.nih.gov/39451224/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,39543170,An interaction network of inner centriole proteins organised by POC1A-POC1B heterodimer crosslinks ensures centriolar integrity.,2024,10.1038/s41467-024-54247-5,https://pubmed.ncbi.nlm.nih.gov/39543170/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,36233334,"Interactions between C8orf37 and FAM161A, Two Ciliary Proteins Essential for Photoreceptor Survival.",2022,10.3390/ijms231912033,https://pubmed.ncbi.nlm.nih.gov/36233334/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,41153400,Inherited Retinal Diseases with High Myopia: A Review.,2025,10.3390/genes16101183,https://pubmed.ncbi.nlm.nih.gov/41153400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,35408898,Translational Read-Through Drugs (TRIDs) Are Able to Restore Protein Expression and Ciliogenesis in Fibroblasts of Patients with Retinitis Pigmentosa Caused by a Premature Termination Codon in FAM161A.,2022,10.3390/ijms23073541,https://pubmed.ncbi.nlm.nih.gov/35408898/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,37729904,Gene augmentation in FAM161A ciliopathy: Toward functional vision rescue.,2023,10.1016/j.ymthe.2023.09.005,https://pubmed.ncbi.nlm.nih.gov/37729904/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,38743010,Poc1 bridges basal body inner junctions to promote triplet microtubule integrity and connections.,2024,10.1083/jcb.202311104,https://pubmed.ncbi.nlm.nih.gov/38743010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,39596218,Radial Data Visualization-Based Step-by-Step Eliminative Algorithm to Predict Colorectal Cancer Patients' Response to FOLFOX Therapy.,2024,10.3390/ijms252212149,https://pubmed.ncbi.nlm.nih.gov/39596218/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,36420180,Retinal Structure and Function in a Knock-in Mouse Model for the FAM161A-p.Arg523∗ Human Nonsense Pathogenic Variant.,2023,10.1016/j.xops.2022.100229,https://pubmed.ncbi.nlm.nih.gov/36420180/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,38927740,Genetic and Clinical Analyses of the &lt;i&gt;KIZ&lt;/i&gt;-c.226C&gt;T Variant Resulting in a Dual Mutational Mechanism.,2024,10.3390/genes15060804,https://pubmed.ncbi.nlm.nih.gov/38927740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,37937284,Case Report: Identification of microduplication in the chromosomal 2p16.1p15 region in an infant suffering from pulmonary arterial hypertension.,2023,10.3389/fcvm.2023.1219480,https://pubmed.ncbi.nlm.nih.gov/37937284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,39062705,Genetic Analysis of 252 Index Cases with Inherited Retinal Diseases Using a Panel of 351 Retinal Genes.,2024,10.3390/genes15070926,https://pubmed.ncbi.nlm.nih.gov/39062705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,33479377,A new mouse model for retinal degeneration due to Fam161a deficiency.,2021,10.1038/s41598-021-81414-1,https://pubmed.ncbi.nlm.nih.gov/33479377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,33093951,Structural bioinformatics predicts that the Retinitis Pigmentosa-28 protein of unknown function FAM161A is a homologue of the microtubule nucleation factor Tpx2.,2020,10.12688/f1000research.25870.1,https://pubmed.ncbi.nlm.nih.gov/33093951/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,37107551,RNA-Seq Profiling between Commercial and Indigenous Iranian Chickens Highlights Differences in Innate Immune Gene Expression.,2023,10.3390/genes14040793,https://pubmed.ncbi.nlm.nih.gov/37107551/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,20705278,Nonsense mutations in FAM161A cause RP28-associated recessive retinitis pigmentosa.,2010,10.1016/j.ajhg.2010.07.018,https://pubmed.ncbi.nlm.nih.gov/20705278/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM161A,ENSG00000170264,Unsafe,20705279,Homozygosity mapping reveals null mutations in FAM161A as a cause of autosomal-recessive retinitis pigmentosa.,2010,10.1016/j.ajhg.2010.07.022,https://pubmed.ncbi.nlm.nih.gov/20705279/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,40071489,Fam163a knockdown and mitochondrial stress in the arcuate nucleus of hypothalamus reduce AgRP neuron activity and differentially regulate mitochondrial dynamics in mice.,2025,10.1111/apha.70020,https://pubmed.ncbi.nlm.nih.gov/40071489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,38716368,Naodesheng Pills Ameliorate Cerebral Ischemia Reperfusion-Induced Ferroptosis via Inhibition of the ERK1/2 Signaling Pathway.,2024,10.2147/dddt.s443479,https://pubmed.ncbi.nlm.nih.gov/38716368/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,41530586,Abnormal PLK2 expression is associated with specific subtypes and may help risk stratification in acute myeloid leukemia.,2026,10.1007/s12672-026-04390-w,https://pubmed.ncbi.nlm.nih.gov/41530586/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,40430058,Effect of Corticosterone on Gene Expression in the Context of Global Hippocampal Transcription.,2025,10.3390/ijms26104889,https://pubmed.ncbi.nlm.nih.gov/40430058/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,31496741,"FAM163A, a positive regulator of ERK signaling pathway, interacts with 14-3-3β and promotes cell proliferation in squamous cell lung carcinoma.",2019,10.2147/ott.s214731,https://pubmed.ncbi.nlm.nih.gov/31496741/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,35303940,BRD4 inhibitor GNE987 exerts anti-cancer effects by targeting super-enhancers in neuroblastoma.,2022,10.1186/s13578-022-00769-8,https://pubmed.ncbi.nlm.nih.gov/35303940/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,33505164,NDSP 09: Risk Assessment of Pakistani Individual for Diabetes (RAPID) - Findings from Second National Diabetes Survey of Pakistan (NDSP) 2016-2017.,2021,10.2147/dmso.s277998,https://pubmed.ncbi.nlm.nih.gov/33505164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,35391800,"Comprehensive Analysis of RNA-Seq in Endometriosis Reveals Competing Endogenous RNA Network Composed of circRNA, lncRNA and mRNA.",2022,10.3389/fgene.2022.828238,https://pubmed.ncbi.nlm.nih.gov/35391800/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,35617703,NDSP-10: The Cardiometabolic Risk Profile with Various Degrees of Dysglycemia in Younger and Older Adults: Findings from the Second National Diabetes Survey of Pakistan 2016-2017.,2022,10.1089/met.2021.0154,https://pubmed.ncbi.nlm.nih.gov/35617703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,31731486,The Role of Aberrant DNA Methylation in Misregulation of Gene Expression in Gonadotroph Nonfunctioning Pituitary Tumors.,2019,10.3390/cancers11111650,https://pubmed.ncbi.nlm.nih.gov/31731486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,37139048,Prediction of drug sensitivity based on multi-omics data using deep learning and similarity network fusion approaches.,2023,10.3389/fbioe.2023.1156372,https://pubmed.ncbi.nlm.nih.gov/37139048/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,32423963,Glycated hemoglobin (HbA1c) as diagnostic criteria for diabetes: the optimal cut-off points values for the Pakistani population; a study from second National Diabetes Survey of Pakistan (NDSP) 2016-2017.,2020,10.1136/bmjdrc-2019-001058,https://pubmed.ncbi.nlm.nih.gov/32423963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,30918751,Identification of an eight-gene signature for survival prediction for patients with hepatocellular carcinoma based on integrated bioinformatics analysis.,2019,10.7717/peerj.6548,https://pubmed.ncbi.nlm.nih.gov/30918751/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,19671756,Neuroblastoma-derived secretory protein is a novel secreted factor overexpressed in neuroblastoma.,2009,10.1158/1535-7163.mct-08-1132,https://pubmed.ncbi.nlm.nih.gov/19671756/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,30082350,"Prevalence of diabetes, pre-diabetes and associated risk factors: second National Diabetes Survey of Pakistan (NDSP), 2016-2017.",2018,10.1136/bmjopen-2017-020961,https://pubmed.ncbi.nlm.nih.gov/30082350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,26325041,Nuclear Receptor Signaling Atlas: Opening Access to the Biology of Nuclear Receptor Signaling Pathways.,2015,10.1371/journal.pone.0135615,https://pubmed.ncbi.nlm.nih.gov/26325041/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,30643443,Current management strategies to target the increasing incidence of diabetes within Pakistan.,2019,10.2147/dmso.s141356,https://pubmed.ncbi.nlm.nih.gov/30643443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,17208556,Neuroblastoma-derived secretory protein messenger RNA levels correlate with high-risk neuroblastoma.,2007,10.1016/j.jpedsurg.2006.09.064,https://pubmed.ncbi.nlm.nih.gov/17208556/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,25612291,Borderline personality disorder and childhood maltreatment: a genome-wide methylation analysis.,2015,10.1111/gbb.12197,https://pubmed.ncbi.nlm.nih.gov/25612291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,30776324,"Cognitive Behavioral Treatment for Acute Posttrauma Distress: A Randomized, Controlled Proof-of-Concept Study Among Hospitalized Adults With Burns.",2020,10.1016/j.apmr.2018.11.027,https://pubmed.ncbi.nlm.nih.gov/30776324/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM163A,ENSG00000143340,Unsafe,31519426,The association between maternal occupation and down syndrome: A report from the national Down syndrome project.,2020,10.1016/j.ijheh.2019.09.001,https://pubmed.ncbi.nlm.nih.gov/31519426/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,41591662,FAM168B identified as a novel candidate target for chimeric antigen receptor T cell-based cancer therapy.,2026,10.1007/s12672-025-03876-3,https://pubmed.ncbi.nlm.nih.gov/41591662/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,42368318,Intergenic trans-splicing-driven formation of a chimeric FAM168B::ANKRD42 transcript in prostate cancer.,2026,10.1007/s13205-026-04920-x,https://pubmed.ncbi.nlm.nih.gov/42368318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,42105569,Aberrant activation of FAM168B via chimeric PLEKHB2::FAM168B mRNA promotes breast invasive cancer progression.,2026,10.1016/j.bbrc.2026.153894,https://pubmed.ncbi.nlm.nih.gov/42105569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,42695583,UPP1 as a Diagnostic Biomarker: Insights from Integrative Bioinformatics and Immune Infiltration Analyses in COPD.,2026,10.3791/72242,https://pubmed.ncbi.nlm.nih.gov/42695583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,42662032,"Cone -beam computed tomographic (CBCT) analysis of root canal volume changes with OneShape, standard Mani -silk and BlueFlex acer file: An &lt;i&gt;in vivo&lt;/i&gt; study.",2026,10.6026/973206300222895,https://pubmed.ncbi.nlm.nih.gov/42662032/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,42412756,Bond strength of debonded orthodontic brackets after different reconditioning and priming protocols: An in vitro study.,2026,10.1371/journal.pone.0353265,https://pubmed.ncbi.nlm.nih.gov/42412756/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,40896030,Effect of Soft Tissue Thickness on Crestal Bone Levels and Implant Stability With Platform-Switched Abutments: A Prospective Study.,2025,10.7759/cureus.88994,https://pubmed.ncbi.nlm.nih.gov/40896030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,40689384,Profile of mild/moderate asthma patients: Baseline data from the MANI cohort.,2025,10.1016/j.waojou.2025.101082,https://pubmed.ncbi.nlm.nih.gov/40689384/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,42535751,Retraction Note.,2026,10.26355/eurrev_202607_37880,https://pubmed.ncbi.nlm.nih.gov/42535751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,39234232,Management of Potential Organ Donor: Indian Society of Critical Care Medicine-Position Statement.,2024,10.5005/jp-journals-10071-24698,https://pubmed.ncbi.nlm.nih.gov/39234232/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,42630753,"Contribution to the genus &lt;i&gt;Balcha&lt;/i&gt; Walker (Hymenoptera, Chalcidoidea, Eupelmidae) of China, with description of a new species and DNA data.",2026,10.3897/zookeys.1289.199128,https://pubmed.ncbi.nlm.nih.gov/42630753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,40546826,Subword Complexes and Kalai's Conjecture on Reconstruction of Spheres.,2025,10.1007/s00454-025-00733-6,https://pubmed.ncbi.nlm.nih.gov/40546826/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,40825844,Exploring weighting schemes for the discovery of informative generalized between pathway models to uncover pathways in genetic interaction networks.,2025,10.1038/s41598-025-16353-2,https://pubmed.ncbi.nlm.nih.gov/40825844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,41578785,Danger in the Classroom: Elemental Mercury Poisoning in Primary School Students.,2025,10.5152/eurasianjmed.2025.251062,https://pubmed.ncbi.nlm.nih.gov/41578785/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,40995718,Impact of Different Nickel-titanium Instruments on Apical Micro-cracks Formation and Residual Amount of Root Canal Filling Materials Following Retreatment Procedure.,2025,10.14744/eej.2025.09226,https://pubmed.ncbi.nlm.nih.gov/40995718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,40671008,Effect of sterilization on the cutting efficiency of two different rotary NiTi instruments (An In- vitro Study).,2025,10.1186/s12903-025-06534-w,https://pubmed.ncbi.nlm.nih.gov/40671008/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,41070466,COVID-19 and Mania: A Case with a One-year Follow UP.,2025,10.5080/u27284,https://pubmed.ncbi.nlm.nih.gov/41070466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,37416084,Interproximal Reduction Facilitating Orthodontic Teeth Extraction.,2023,10.7759/cureus.41403,https://pubmed.ncbi.nlm.nih.gov/37416084/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,40443586,"A Comparison of Disinfecting Ability of Peracetic Acid, Glutaraldehyde and Autoclaving on Endodontic K-files Tested Against Enterococcus faecalis: An In-Vitro Study.",2025,10.7759/cureus.83168,https://pubmed.ncbi.nlm.nih.gov/40443586/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,32745624,Copper stress induces zebrafish central neural system myelin defects via WNT/NOTCH-hoxb5b signaling and pou3f1/fam168a/fam168b DNA methylation.,2020,10.1016/j.bbagrm.2020.194612,https://pubmed.ncbi.nlm.nih.gov/32745624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,41631609,Survival and life history of Psix saccharicola (Hymenoptera: Scelionidae) in frozen host eggs and after cold storage as pupae.,2026,10.1093/jee/toag005,https://pubmed.ncbi.nlm.nih.gov/41631609/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,40470854,[Pilot study of a cluster randomized controlled trial to assess the efficacy of ultraviolet light in improving hand hygiene in hospital staff].,2025,10.1702/4514.45117,https://pubmed.ncbi.nlm.nih.gov/40470854/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,40682562,"Parasitism of Acrosternum arabicum (Hemiptera: Pentatomidae) by the egg parasitoid, Psix saccharicola (Hymenoptera: Scelionidae) as a function of female age, host age, and host density.",2025,10.1093/jee/toaf183,https://pubmed.ncbi.nlm.nih.gov/40682562/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,41670930,"Asthma Awareness Questionnaire: Development, Psychometric Validation, and Extent.",2026,10.1007/s41030-026-00342-5,https://pubmed.ncbi.nlm.nih.gov/41670930/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,40940090,Biosensors based on DNA aptamers for detection of bacterial pathogens in food.,2025,10.1016/bs.afnr.2025.04.007,https://pubmed.ncbi.nlm.nih.gov/40940090/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,42474613,Global research trends in sexual function outcomes after robot-assisted radical prostatectomy: a bibliometric and visualization study.,2026,10.1007/s11701-026-03672-3,https://pubmed.ncbi.nlm.nih.gov/42474613/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,40034932,Frequency of &lt;i&gt;Human Papillomavirus&lt;/i&gt; Genotypes among Women with Genital Wart Using Molecular Hybridization Methods.,2024,10.30699/ijp.2024.2013097.3182,https://pubmed.ncbi.nlm.nih.gov/40034932/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,34174937,Recommendations for designing and analysing multi-arm non-inferiority trials: a review of methodology and current practice.,2021,10.1186/s13063-021-05364-9,https://pubmed.ncbi.nlm.nih.gov/34174937/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,38683414,New suture probe canaloplasty combined with suprachoroidal collagen implantation.,2024,10.1007/s10792-024-03135-4,https://pubmed.ncbi.nlm.nih.gov/38683414/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,36540585,The Effect of Commonly Used Fixed-Dose Single Pill Combinations of Renin-Angiotensin-System Blockers and Calcium Channel Blockers on HOMA-IR Index in Hypertensive Patients with Impaired Fasting Glucose: a 12-Week Randomized Open-Label Prospective Study.,2022,10.26574/maedica.2022.17.3.561,https://pubmed.ncbi.nlm.nih.gov/36540585/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,39748358,Comparison of the pull-out force of different microtube-based methods in fractured endodontic instrument removal: An in-vitro study.,2025,10.1186/s12903-024-05370-8,https://pubmed.ncbi.nlm.nih.gov/39748358/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,38263557,A novel technique to detect cover screw location at stage two uncovery surgery over conventional technique - A randomized controlled trial.,2024,10.4103/jips.jips_395_23,https://pubmed.ncbi.nlm.nih.gov/38263557/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,38477011,Indian Society of Critical Care Medicine and Indian Association of Palliative Care Expert Consensus and Position Statements for End-of-life and Palliative Care in the Intensive Care Unit.,2024,10.5005/jp-journals-10071-24661,https://pubmed.ncbi.nlm.nih.gov/38477011/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM168B,ENSG00000152102,Unsafe,20716133,The novel protein MANI modulates neurogenesis and neurite-cone growth.,2011,10.1111/j.1582-4934.2010.01134.x,https://pubmed.ncbi.nlm.nih.gov/20716133/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM181A,ENSG00000140067,Unsafe,36482943,Decreased Expression of a Novel lncRNA FAM181A-AS1 is Associated with Poor Prognosis and Immune Infiltration in Lung Adenocarcinoma.,2022,10.2147/pgpm.s384901,https://pubmed.ncbi.nlm.nih.gov/36482943/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM181A,ENSG00000140067,Unsafe,34253288,"Knockout of the family with sequence similarity 181, member A (Fam181a) gene does not impair spermatogenesis or male fertility in the mouse.",2021,10.1071/rd21150,https://pubmed.ncbi.nlm.nih.gov/34253288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM181A,ENSG00000140067,Unsafe,33080570,LncRNA FAM181A-AS1 promotes gliomagenesis by sponging miR-129-5p and upregulating ZRANB2.,2020,10.18632/aging.103391,https://pubmed.ncbi.nlm.nih.gov/33080570/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM181A,ENSG00000140067,Unsafe,36060266,"A cuproptosis-related lncRNAs signature for prognosis, chemotherapy, and immune checkpoint blockade therapy of low-grade glioma.",2022,10.3389/fmolb.2022.966843,https://pubmed.ncbi.nlm.nih.gov/36060266/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM181A,ENSG00000140067,Unsafe,35642209,Identification of Three Prognosis-Related Differentially Expressed lncRNAs Driven by Copy Number Variation in Thyroid Cancer.,2022,10.1155/2022/9203796,https://pubmed.ncbi.nlm.nih.gov/35642209/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM181A,ENSG00000140067,Unsafe,31697419,Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors.,2020,10.1002/pro.3775,https://pubmed.ncbi.nlm.nih.gov/31697419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM181A,ENSG00000140067,Unsafe,35345333,Machine learning on thyroid disease: a review.,2022,10.31083/j.fbl2703101,https://pubmed.ncbi.nlm.nih.gov/35345333/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM181A,ENSG00000140067,Unsafe,26407640,"Analysis of the Fam181 gene family during mouse development reveals distinct strain-specific expression patterns, suggesting a role in nervous system development and function.",2016,10.1016/j.gene.2015.09.035,https://pubmed.ncbi.nlm.nih.gov/26407640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM181A,ENSG00000140067,Unsafe,25288825,Epigenome variation in severe asthma.,2015,10.1177/1099800414553463,https://pubmed.ncbi.nlm.nih.gov/25288825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM181A,ENSG00000140067,Unsafe,27287773,Genome-wide association for milk production and female fertility traits in Canadian dairy Holstein cattle.,2016,10.1186/s12863-016-0386-1,https://pubmed.ncbi.nlm.nih.gov/27287773/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM209A,ENSG00000124103,Unsafe,37118964,Differential Proteomic Analysis of Human Sperm: A Systematic Review to Identify Candidate Targets to Monitor Sperm Quality.,2024,10.5534/wjmh.220262,https://pubmed.ncbi.nlm.nih.gov/37118964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM209A,ENSG00000124103,Unsafe,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM209B,ENSG00000213714,Unsafe,41074104,Saliva as a potential and non-invasive approach to identify upregulated genes associated with comorbidities of T1DM: a brief report.,2025,10.1186/s40001-025-03105-1,https://pubmed.ncbi.nlm.nih.gov/41074104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM209B,ENSG00000213714,Unsafe,37867507,Identification of biomarkers associated with immune scores in diabetic retinopathy.,2023,10.3389/fendo.2023.1228843,https://pubmed.ncbi.nlm.nih.gov/37867507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM229A,ENSG00000225828,Unsafe,35708078,Genome-Wide CRISPR-Cas9 Screening and Identification of Potential Genes Promoting Prostate Cancer Growth and Metastasis.,2022,10.2174/1568009622666220615154137,https://pubmed.ncbi.nlm.nih.gov/35708078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM229B,ENSG00000203778,Unsafe,32295841,Learning-induced mRNA alterations in olfactory bulb mitral cells in neonatal rats.,2020,10.1101/lm.051177.119,https://pubmed.ncbi.nlm.nih.gov/32295841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,42159844,FAM72A Knockdown Drives Cell Mitophagy and Pyroptosis in Ovarian Cancer Via the PINK1/Parkin Pathway.,2026,10.1007/s12010-026-05718-6,https://pubmed.ncbi.nlm.nih.gov/42159844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,42174281,FAM72A is associated with lung cancer proliferation and migration via the NF‑κB signaling pathway.,2026,10.1007/s00438-026-02450-y,https://pubmed.ncbi.nlm.nih.gov/42174281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,42892655,"Multimodal substrate recruitment enables CTLH&lt;sup&gt;MKLN1&lt;/sup&gt; E3 ligase to target acetylated N-, C-, and internal degrons.",2026,10.1038/s41467-026-78311-4,https://pubmed.ncbi.nlm.nih.gov/42892655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,41414706,Cell cycle-regulated expression of Fam72a from the |Srgap2-Fam72a| master gene leads to Mis18a downregulation.,2026,10.1080/15384101.2025.2602824,https://pubmed.ncbi.nlm.nih.gov/41414706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,40604025,FAM72A promotes UNG2 degradation and mutagenesis in human cancer cells.,2025,10.1038/s41598-025-07723-x,https://pubmed.ncbi.nlm.nih.gov/40604025/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,41378103,Systematic analysis of the expression profiles and prognostic values of the FAM72 family in liver cancer.,2025,10.1016/j.bbrep.2025.102358,https://pubmed.ncbi.nlm.nih.gov/41378103/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,41071453,FAM72A Promotes Colorectal Cancer Progression by Regulating Reactive Oxygen Species and Inhibiting Cellular Pyroptosis.,2026,10.1007/s10620-025-09416-x,https://pubmed.ncbi.nlm.nih.gov/41071453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,41114845,FAM72A promotes cervical cancer progression by regulating the PI3K pathway.,2025,10.1007/s10142-025-01735-6,https://pubmed.ncbi.nlm.nih.gov/41114845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,40838616,MKLN1-dependent GID4/CTLH E3 ubiquitin ligase complex assemblies are required to support B-cell antibody diversification.,2025,10.1093/jimmun/vkaf201,https://pubmed.ncbi.nlm.nih.gov/40838616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,39129160,Expression and Function of FAM72A Gene in Multiple MyelomaFAM72A.,2025,10.2174/0113892010311258240729080309,https://pubmed.ncbi.nlm.nih.gov/39129160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,39215025,FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation.,2024,10.1038/s41467-024-52009-x,https://pubmed.ncbi.nlm.nih.gov/39215025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,38370373,Erratum: FAM72A promotes glioma progression by regulating mitophagy through the Pink1/Parkin signaling pathway: Erratum.,2024,10.7150/jca.93189,https://pubmed.ncbi.nlm.nih.gov/38370373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,37151394,FAM72A promotes glioma progression by regulating mitophagy through the Pink1/Parkin signaling pathway.,2023,10.7150/jca.82949,https://pubmed.ncbi.nlm.nih.gov/37151394/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,36613817,Prognostic and Immunological Implications of FAM72A in Pan-Cancer and Functional Validations.,2022,10.3390/ijms24010375,https://pubmed.ncbi.nlm.nih.gov/36613817/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,40688037,The identification of novel missense variant in &lt;i&gt;ChAT&lt;/i&gt; gene in a patient with gestational diabetes denotes plausible genetic association.,2025,10.1515/med-2025-1225,https://pubmed.ncbi.nlm.nih.gov/40688037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,40081285,FAM72 family members serves as prognostic biomarker in liver hepatocellular carcinoma.,2025,10.1016/j.prp.2025.155893,https://pubmed.ncbi.nlm.nih.gov/40081285/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,36483027,"Integrated systemic analysis of FAM72A to identify its clinical relevance, biological function, and relationship to drug sensitivity in hepatocellular carcinoma.",2022,10.3389/fonc.2022.1046473,https://pubmed.ncbi.nlm.nih.gov/36483027/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,36757015,The pan-cancer analysis of the oncogenic role of FAM72A as a BRCA prognostic biomarker and immunotherapeutic target.,2023,10.1002/tox.23751,https://pubmed.ncbi.nlm.nih.gov/36757015/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,41351409,Epirubicin Induces Cell Cycle Arrest in Multiple Myeloma Cells by Downregulating CDC20 Expression.,2025,10.31083/fbl46326,https://pubmed.ncbi.nlm.nih.gov/41351409/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,37086493,Family with Sequence Similarity 72 (FAM72) - A prospective biomarker for poor prognosis in patients with oral squamous cell carcinoma.,2023,10.1016/j.archoralbio.2023.105695,https://pubmed.ncbi.nlm.nih.gov/37086493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,37275958,"FAM family gene prediction model reveals heterogeneity, stemness and immune microenvironment of UCEC.",2023,10.3389/fmolb.2023.1200335,https://pubmed.ncbi.nlm.nih.gov/37275958/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,33686947,FAM72 serves as a biomarker of poor prognosis in human lung adenocarcinoma.,2021,10.18632/aging.202625,https://pubmed.ncbi.nlm.nih.gov/33686947/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,34819670,FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.,2021,10.1038/s41586-021-04144-4,https://pubmed.ncbi.nlm.nih.gov/34819670/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,33962170,Immunogenicity and structural efficacy of P41 of Plasmodium sp. as potential cross-species blood-stage malaria vaccine.,2021,10.1016/j.compbiolchem.2021.107493,https://pubmed.ncbi.nlm.nih.gov/33962170/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,33940529,Structural and immunogenicity analysis of reconstructed ancestral and consensus P48/45 for cross-species anti malaria transmission-blocking vaccine.,2021,10.1016/j.compbiolchem.2021.107495,https://pubmed.ncbi.nlm.nih.gov/33940529/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,34646501,Sequence diversity and evolution of infectious bursal disease virus in Iraq.,2021,10.12688/f1000research.28421.2,https://pubmed.ncbi.nlm.nih.gov/34646501/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,35368665,A Novel Prognostic Model for Identifying the Risk of Hepatocellular Carcinoma Based on Angiogenesis Factors.,2022,10.3389/fgene.2022.857215,https://pubmed.ncbi.nlm.nih.gov/35368665/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,33868990,Identification of Mitochondrial-Related Prognostic Biomarkers Associated With Primary Bile Acid Biosynthesis and Tumor Microenvironment of Hepatocellular Carcinoma.,2021,10.3389/fonc.2021.587479,https://pubmed.ncbi.nlm.nih.gov/33868990/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM72A,ENSG00000196550,Unsafe,18676834,"Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase.",2008,10.1158/0008-5472.can-08-1259,https://pubmed.ncbi.nlm.nih.gov/18676834/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM76B,ENSG00000077458,Unsafe,39912396,miR-448-3p/miR-1264-3p Participates in Intermittent Hypoxic Response in Hippocampus by Regulating Fam76b/hnRNPA2B1.,2025,10.1111/cns.70239,https://pubmed.ncbi.nlm.nih.gov/39912396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM76B,ENSG00000077458,Unsafe,38421448,FAM76B regulates PI3K/Akt/NF-κB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA.,2024,10.1007/s00018-024-05133-2,https://pubmed.ncbi.nlm.nih.gov/38421448/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM76B,ENSG00000077458,Unsafe,37643469,FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1.,2023,10.7554/elife.85659,https://pubmed.ncbi.nlm.nih.gov/37643469/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM76B,ENSG00000077458,Unsafe,37838209,Expression and functional analysis of fam76b in zebrafish.,2023,10.1016/j.fsi.2023.109161,https://pubmed.ncbi.nlm.nih.gov/37838209/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM76B,ENSG00000077458,Unsafe,41097675,Novel &lt;i&gt;MAML2&lt;/i&gt; Fusions in Human Malignancy.,2025,10.3390/cancers17193146,https://pubmed.ncbi.nlm.nih.gov/41097675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM76B,ENSG00000077458,Unsafe,39285408,Clinicopathological characteristics and genetic features of young and senior Ewing sarcoma patients.,2024,10.1186/s13000-024-01548-4,https://pubmed.ncbi.nlm.nih.gov/39285408/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM76B,ENSG00000077458,Unsafe,27018871,Production and Characterization of Monoclonal Antibodies against Human Nuclear Protein FAM76B.,2016,10.1371/journal.pone.0152237,https://pubmed.ncbi.nlm.nih.gov/27018871/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM76B,ENSG00000077458,Unsafe,31756428,Comprehensive analysis of long non-coding RNAs expression pattern in the pathogenesis of pulmonary tuberculosis.,2020,10.1016/j.ygeno.2019.11.009,https://pubmed.ncbi.nlm.nih.gov/31756428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM76B,ENSG00000077458,Unsafe,32920024,"Looking for Sunshine: Genetic Predisposition to Sun Seeking in 265,000 Individuals of European Ancestry.",2021,10.1016/j.jid.2020.08.014,https://pubmed.ncbi.nlm.nih.gov/32920024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM76B,ENSG00000077458,Unsafe,35425820,Association of Circulating Cathepsin B Levels With Blood Pressure and Aortic Dilation.,2022,10.3389/fcvm.2022.762468,https://pubmed.ncbi.nlm.nih.gov/35425820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM76B,ENSG00000077458,Unsafe,40753849,Deletion of FAM76B histidine-rich region enhances macrophage-mediated osteosarcoma inhibition via liquid-liquid phase separation.,2025,10.1016/j.intimp.2025.115289,https://pubmed.ncbi.nlm.nih.gov/40753849/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM78B,ENSG00000188859,Unsafe,42174678,Sex differences in cardiac recovery and ventricular gene expression in a rat model of donation after circulatory death.,2026,10.1186/s13293-026-00915-8,https://pubmed.ncbi.nlm.nih.gov/42174678/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM78B,ENSG00000188859,Unsafe,39467528,Thiamine-Responsive Megaloblastic Anemia Syndrome Mimicking Myelodysplastic Neoplasm.,2025,10.1159/000542286,https://pubmed.ncbi.nlm.nih.gov/39467528/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM78B,ENSG00000188859,Unsafe,34124712,Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes.,2021,10.37349/emed.2021.00032,https://pubmed.ncbi.nlm.nih.gov/34124712/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM78B,ENSG00000188859,Unsafe,25813534,Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study.,2015,10.3892/ijmm.2015.2151,https://pubmed.ncbi.nlm.nih.gov/25813534/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM81B,ENSG00000153347,Unsafe,42589347,Genetic Architecture of Growth Traits in Turbot (&lt;i&gt;Scophthalmus maximus&lt;/i&gt;) Revealed by Genome-Wide Association Studies.,2026,10.3390/ijms27156689,https://pubmed.ncbi.nlm.nih.gov/42589347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM81B,ENSG00000153347,Unsafe,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM81B,ENSG00000153347,Unsafe,33965253,Histopathological typing in diffuse malignant epithelioid mesothelioma: implication for prognosis and molecular basis.,2021,10.1016/j.pathol.2021.01.010,https://pubmed.ncbi.nlm.nih.gov/33965253/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM81B,ENSG00000153347,Unsafe,27491861,LRG1 mRNA expression in breast cancer associates with PIK3CA genotype and with aromatase inhibitor therapy outcome.,2016,10.1016/j.molonc.2016.07.004,https://pubmed.ncbi.nlm.nih.gov/27491861/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,39867833,Cancer-associated fibroblast-derived exosomal FAM83F regulates KIF23 expression to promote the malignant progression and reduce radiosensitivity in non-small cell lung cancer.,2025,10.1007/s10616-025-00713-x,https://pubmed.ncbi.nlm.nih.gov/39867833/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,39437839,Zebrafish reveal new roles for Fam83f in hatching and the DNA damage-mediated autophagic response.,2024,10.1098/rsob.240194,https://pubmed.ncbi.nlm.nih.gov/39437839/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,38104106,Upregulation of FAM83F by c-Myc promotes cervical cancer growth and aerobic glycolysis via Wnt/β-catenin signaling activation.,2023,10.1038/s41419-023-06377-9,https://pubmed.ncbi.nlm.nih.gov/38104106/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,35650627,"Comprehensive analysis of the expression, prognostic significance, and function of FAM83 family members in breast cancer.",2022,10.1186/s12957-022-02636-9,https://pubmed.ncbi.nlm.nih.gov/35650627/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,33361109,FAM83F regulates canonical Wnt signalling through an interaction with CK1α.,2021,10.26508/lsa.202000805,https://pubmed.ncbi.nlm.nih.gov/33361109/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,36206095,Blocking circ_0010235 suppresses acquired paclitaxel resistance of non-small cell lung cancer by sponging miR-512-5p to modulate FAM83F expression.,2022,10.1097/cad.0000000000001388,https://pubmed.ncbi.nlm.nih.gov/36206095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,30692643,Fam83F induces p53 stabilisation and promotes its activity.,2019,10.1038/s41418-019-0281-1,https://pubmed.ncbi.nlm.nih.gov/30692643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,30881348,The Highly Expressed FAM83F Protein in Papillary Thyroid Cancer Exerts a Pro-Oncogenic Role in Thyroid Follicular Cells.,2019,10.3389/fendo.2019.00134,https://pubmed.ncbi.nlm.nih.gov/30881348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,33361334,IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling.,2021,10.26508/lsa.202000804,https://pubmed.ncbi.nlm.nih.gov/33361334/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,33560141,"Circ_0000735 enhances the proliferation, metastasis and glycolysis of non-small cell lung cancer by regulating the miR-635/FAM83F axis.",2021,10.1080/01902148.2021.1881188,https://pubmed.ncbi.nlm.nih.gov/33560141/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,39505304,An integrative lipidomics and transcriptomics study revealing Bavachin and Icariin synergistically induce idiosyncratic liver injury.,2024,10.1080/08923973.2024.2424293,https://pubmed.ncbi.nlm.nih.gov/39505304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,30556880,MiR-650 inhibits the progression of glioma by targeting FAM83F.,2018,10.26355/eurrev_201812_16537,https://pubmed.ncbi.nlm.nih.gov/30556880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,32783691,Serum-Derived Exosomes-Mediated Circular RNA ARHGAP10 Modulates the Progression of Non-Small Cell Lung Cancer Through the miR-638/FAM83F Axis.,2022,10.1089/cbr.2019.3534,https://pubmed.ncbi.nlm.nih.gov/32783691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,31595558,MiR-1827 functions as a tumor suppressor in lung adenocarcinoma by targeting MYC and FAM83F.,2020,10.1002/jcb.29402,https://pubmed.ncbi.nlm.nih.gov/31595558/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,30280778,MiR-940 inhibits the progression of NSCLC by targeting FAM83F.,2018,10.26355/eurrev_201809_15927,https://pubmed.ncbi.nlm.nih.gov/30280778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,28770965,MiR-455-3p acts as a prognostic marker and inhibits the proliferation and invasion of esophageal squamous cell carcinoma by targeting FAM83F.,2017,,https://pubmed.ncbi.nlm.nih.gov/28770965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,26758433,miR-143 inhibits tumor progression by targeting FAM83F in esophageal squamous cell carcinoma.,2016,10.1007/s13277-015-4760-9,https://pubmed.ncbi.nlm.nih.gov/26758433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,33447073,Identification of Four Genes as Prognosis Signatures in Lung Adenocarcinoma Microenvironment.,2021,10.2147/pgpm.s283414,https://pubmed.ncbi.nlm.nih.gov/33447073/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM83F,ENSG00000133477,Unsafe,28088687,Whole-Genome DNA Methylation Profiling Identifies Epigenetic Signatures of Uterine Carcinosarcoma.,2017,10.1016/j.neo.2016.12.009,https://pubmed.ncbi.nlm.nih.gov/28088687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM90A1,ENSG00000171847,Unsafe,41866138,DNA methylation as a predictor of pituitary neuroendocrine tumour behaviour: A systematic review.,2026,10.1111/jne.70167,https://pubmed.ncbi.nlm.nih.gov/41866138/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM90A1,ENSG00000171847,Unsafe,41052974,Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants.,2025,10.1038/s41398-025-03578-y,https://pubmed.ncbi.nlm.nih.gov/41052974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM90A1,ENSG00000171847,Unsafe,41013918,Sequencing Analysis Demonstrates That a Complex Genetic Architecture Contributes to Risk for Spina Bifida.,2025,10.1002/bdr2.2533,https://pubmed.ncbi.nlm.nih.gov/41013918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM90A1,ENSG00000171847,Unsafe,32015217,Integrated analysis of DNA methylation and mRNA expression profiles to identify key genes involved in the regrowth of clinically non-functioning pituitary adenoma.,2020,10.18632/aging.102751,https://pubmed.ncbi.nlm.nih.gov/32015217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9B,ENSG00000177138,Unsafe,37594251,Scrutinizing the human TEX genes in the context of human male infertility.,2024,10.1111/andr.13511,https://pubmed.ncbi.nlm.nih.gov/37594251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9B,ENSG00000177138,Unsafe,34507348,FAM9B serves as a novel meiosis-related protein localized in meiotic chromosome cores and is associated with human gametogenesis.,2021,10.1371/journal.pone.0257248,https://pubmed.ncbi.nlm.nih.gov/34507348/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9B,ENSG00000177138,Unsafe,36017582,Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia.,2022,10.1111/andr.13269,https://pubmed.ncbi.nlm.nih.gov/36017582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9B,ENSG00000177138,Unsafe,38233393,"X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements.",2024,10.1038/s41467-024-44709-1,https://pubmed.ncbi.nlm.nih.gov/38233393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9B,ENSG00000177138,Unsafe,35022708,Ancestry- and sex-specific effects underlying inguinal hernia susceptibility identified in a multiethnic genome-wide association study meta-analysis.,2022,10.1093/hmg/ddac003,https://pubmed.ncbi.nlm.nih.gov/35022708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9B,ENSG00000177138,Unsafe,29325096,Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men.,2018,10.1210/jc.2017-02060,https://pubmed.ncbi.nlm.nih.gov/29325096/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9B,ENSG00000177138,Unsafe,29371518,Preliminary Evidence for Aortopathy and an X-Linked Parent-of-Origin Effect on Aortic Valve Malformation in a Mouse Model of Turner Syndrome.,2015,10.3390/jcdd2030190,https://pubmed.ncbi.nlm.nih.gov/29371518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9B,ENSG00000177138,Unsafe,30362198,Comprehensive analysis of coexpressed long noncoding RNAs and genes in breast cancer.,2019,10.1111/jog.13840,https://pubmed.ncbi.nlm.nih.gov/30362198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9B,ENSG00000177138,Unsafe,22936694,Genome-wide association study identifies a new locus JMJD1C at 10q21 that may influence serum androgen levels in men.,2012,10.1093/hmg/dds361,https://pubmed.ncbi.nlm.nih.gov/22936694/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9B,ENSG00000177138,Unsafe,21998597,Genetic determinants of serum testosterone concentrations in men.,2011,10.1371/journal.pgen.1002313,https://pubmed.ncbi.nlm.nih.gov/21998597/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9B,ENSG00000177138,Unsafe,12213195,A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region.,2002,10.1006/geno.2002.6834,https://pubmed.ncbi.nlm.nih.gov/12213195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9C,ENSG00000187268,Unsafe,36017582,Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia.,2022,10.1111/andr.13269,https://pubmed.ncbi.nlm.nih.gov/36017582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9C,ENSG00000187268,Unsafe,23836295,FAM9C plays an anti-apoptotic role through activation of the PI3K/Akt pathway in human hepatocellular carcinoma.,2013,10.3892/or.2013.2592,https://pubmed.ncbi.nlm.nih.gov/23836295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FAM9C,ENSG00000187268,Unsafe,12213195,A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region.,2002,10.1006/geno.2002.6834,https://pubmed.ncbi.nlm.nih.gov/12213195/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,42432871,Prenatal Diagnosis of a Fetus With Congenital Malformations Caused by Compound Heterozygous Mutations in FANCA: A Case Report and Literature Review.,2026,10.1002/mgg3.70259,https://pubmed.ncbi.nlm.nih.gov/42432871/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,42436270,Aurora kinase A is a synthetic lethal target in FANCA-deficient cancers.,2026,10.1038/s41698-026-01596-7,https://pubmed.ncbi.nlm.nih.gov/42436270/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,42755940,Integrative proteomics defines FANCA as a multifunctional hub linking DNA repair to translation.,2026,10.1016/j.isci.2026.117461,https://pubmed.ncbi.nlm.nih.gov/42755940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,42102045,Using fractal model and factor analysis for FACA modeling and its application in deep mineral prediction.,2026,10.1371/journal.pone.0348494,https://pubmed.ncbi.nlm.nih.gov/42102045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,42302790,FANCA-dependent FEN1 recruitment suppresses transcription-replication conflicts and PARPi sensitivity.,2026,10.1016/j.molcel.2026.05.027,https://pubmed.ncbi.nlm.nih.gov/42302790/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,41124260,"An overhead-reduced, efficient, fully analog neural-network computing hardware.",2025,10.1126/sciadv.adv7555,https://pubmed.ncbi.nlm.nih.gov/41124260/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,41764196,Beyond readthrough: ataluren restores mitochondrial function and reduces oxidative stress in FANCA-mutated cells via mTOR-DRP1 modulation.,2026,10.1038/s41420-026-02983-6,https://pubmed.ncbi.nlm.nih.gov/41764196/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,40146775,Oncogenic properties of wild-type DNA repair gene FANCA in breast cancer.,2025,10.1016/j.celrep.2025.115480,https://pubmed.ncbi.nlm.nih.gov/40146775/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,42704849,Large-scale pleiotropic analysis across cancers reveals shared genetic mechanisms and identifies novel functional genes.,2026,10.1093/bib/bbag479,https://pubmed.ncbi.nlm.nih.gov/42704849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,41733882,Differential genetic analysis of ectrodactyly in a Fanconi anemia pedigree with FANCA mutations.,2026,10.1007/s11684-026-1202-6,https://pubmed.ncbi.nlm.nih.gov/41733882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,39375712,FANCA promotes lung adenocarcinoma progression and is a potential target for epitope vaccine immunotherapy.,2024,10.1186/s12967-024-05675-w,https://pubmed.ncbi.nlm.nih.gov/39375712/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,42691050,EIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathy.,2026,10.1371/journal.pone.0355473,https://pubmed.ncbi.nlm.nih.gov/42691050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,41171815,A porcine model of Fanconi anemia.,2025,10.1371/journal.pone.0335854,https://pubmed.ncbi.nlm.nih.gov/41171815/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,41746738,Insights and modulation of RNA polymerase-dependent R-loop and dsRNA in Fanconi anemia hematopoietic stem cells.,2026,10.1172/jci.insight.192126,https://pubmed.ncbi.nlm.nih.gov/41746738/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,40544182,Development of translational read-through-inducing drugs as novel therapeutic options for patients with Fanconi anemia.,2025,10.1038/s41420-025-02571-0,https://pubmed.ncbi.nlm.nih.gov/40544182/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,42881567,Fanconi Anemia: Matrix Remodeling and Oral Carcinogenesis.,2026,10.1177/00220345261478636,https://pubmed.ncbi.nlm.nih.gov/42881567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,39885916,Unveiling a pathogenic FANCA gene variant in a Mexican family with Fanconi anemia through next‑generation sequencing.,2025,10.3892/etm.2025.12798,https://pubmed.ncbi.nlm.nih.gov/39885916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,42405007,Case of Myelodysplastic Syndrome 15 Years After Kidney Transplantation Under Long-Term Immunosuppression.,2026,10.1155/crh/1471228,https://pubmed.ncbi.nlm.nih.gov/42405007/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,42489677,A Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02.,2026,10.1158/1078-0432.ccr-25-1114,https://pubmed.ncbi.nlm.nih.gov/42489677/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,42587126,Excess folate elevates formaldehyde genotoxicity in cell lines but not in mice or humans.,2026,10.1038/s44321-026-00504-7,https://pubmed.ncbi.nlm.nih.gov/42587126/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,42196345,Squamous Cell Carcinoma of the Skin in a Teenager with Fanconi Anemia: A Challenging Treatment.,2026,10.3390/ijms27104366,https://pubmed.ncbi.nlm.nih.gov/42196345/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,41794844,DNA Repair gene alterations and efficacy from gemcitabine and nab-paclitaxel with/without durvalumab and tremelimumab in metastatic pancreatic ductal adenocarcinoma.,2026,10.1038/s41467-026-70120-z,https://pubmed.ncbi.nlm.nih.gov/41794844/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,41231232,BrUOG360: A Phase Ib/II Study of Copanlisib in Combination with Rucaparib in Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC).,2025,10.1158/2767-9764.crc-25-0651,https://pubmed.ncbi.nlm.nih.gov/41231232/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,42061199,Spectral prediction of the botanical identity of organ powders from Zanthoxylum zanthoxyloides (Lam.) Zepernick and Timler.,2026,10.1016/j.saa.2026.127965,https://pubmed.ncbi.nlm.nih.gov/42061199/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,40066447,Case Report: Complete response to four cycles of camrelizumab in a PD-L1 negative patient with advanced oral squamous cancer.,2025,10.3389/fimmu.2025.1476455,https://pubmed.ncbi.nlm.nih.gov/40066447/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,40617222,Environmental arsenic hijacks DDX5-mediated FANCA splicing to impair R-loops resolution and drive ovarian aging.,2025,10.1016/j.ecoenv.2025.118605,https://pubmed.ncbi.nlm.nih.gov/40617222/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,41991439,Efficacy and safety of gene therapy in pediatric patients with Fanconi anemia: a systematic review.,2026,10.1016/j.anpede.2026.504176,https://pubmed.ncbi.nlm.nih.gov/41991439/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,39640282,A phase II study evaluating safety and efficacy of niraparib in patients with previously treated homologous recombination defective metastatic esophageal/gastroesophageal junction/proximal gastric adenocarcinoma.,2024,10.3389/fonc.2024.1435056,https://pubmed.ncbi.nlm.nih.gov/39640282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,41587107,Evolution of AR and Non-AR Alterations in ctDNA of Patients with Metastatic Prostate Cancer Treated in the Phase III Alliance A031201 Trial.,2026,10.1158/1078-0432.ccr-25-2779,https://pubmed.ncbi.nlm.nih.gov/41587107/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCA,ENSG00000187741,Unsafe,42649894,Real-World Germline Testing Patterns and Clinical Implications of HRR-Associated Germline Variants in Pancreatic Ductal Adenocarcinoma.,2026,10.3390/cancers18162580,https://pubmed.ncbi.nlm.nih.gov/42649894/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,42715099,FANCM is required for the PAX3::FOXO1-driven oncogenic program in rhabdomyosarcoma.,2026,10.1016/j.celrep.2026.117960,https://pubmed.ncbi.nlm.nih.gov/42715099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,42606197,Disulfide engineering of the FANCM-MHF complex reveals constraints on crosslink design in symmetric oligomers.,2026,10.1002/pro.70761,https://pubmed.ncbi.nlm.nih.gov/42606197/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,42760352,The BRCA1 coiled-coil domain is dispensable for suppression of tandem duplications and tolerance of FANCM loss.,2026,10.1038/s44318-026-00913-x,https://pubmed.ncbi.nlm.nih.gov/42760352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,42778593,MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness.,2026,10.1038/s41586-026-11048-8,https://pubmed.ncbi.nlm.nih.gov/42778593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,38927643,FANCM Gene Variants in a Male Diagnosed with Sertoli Cell-Only Syndrome and Diffuse Astrocytoma.,2024,10.3390/genes15060707,https://pubmed.ncbi.nlm.nih.gov/38927643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,42494996,"Concordant high-grade glioma in monozygotic twins with germline variants in ATM, FANCC, and FANCM: a case report on combined DNA repair deficiency.",2026,10.1093/noajnl/vdag172,https://pubmed.ncbi.nlm.nih.gov/42494996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,41223770,Large-scale meta-analysis and precision functional assays identify FANCM regions in which PTVs confer different risks for ER-negative and triple-negative breast cancer.,2026,10.1016/j.breast.2025.104619,https://pubmed.ncbi.nlm.nih.gov/41223770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,40832744,"Homozygous FANCM Variant c.5101C&gt;T p.(Gln1701*) in a Patient With Early Onset Breast Cancer, Chemotherapy Toxicity, and Chromosome Fragility: A Case Report.",2025,10.1002/cnr2.70283,https://pubmed.ncbi.nlm.nih.gov/40832744/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,42098304,SLX4IP limits replication stress globally and at ALT telomeres.,2026,10.1038/s44318-026-00790-4,https://pubmed.ncbi.nlm.nih.gov/42098304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,41973757,Chronic replication stress-mediated genomic instability disrupts placenta development in mice.,2026,10.1371/journal.pgen.1012111,https://pubmed.ncbi.nlm.nih.gov/41973757/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,41533569,The SMC5/SMC6 complex is critical for resolving R-loop-induced transcription-replication conflicts.,2026,10.1093/nar/gkaf1537,https://pubmed.ncbi.nlm.nih.gov/41533569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,41719405,RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity.,2026,10.1126/sciadv.aea5932,https://pubmed.ncbi.nlm.nih.gov/41719405/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,40125273,Targeting FANCM by antisense oligonucleotides in ALT-positive cancers.,2025,10.1016/j.omtn.2025.102492,https://pubmed.ncbi.nlm.nih.gov/40125273/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,42858234,Fanconi anemia pathway disruption drives lomustine sensitivity in glioma.,2026,10.1093/neuonc/noag254,https://pubmed.ncbi.nlm.nih.gov/42858234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,41070293,"Association of Genetic Risk Variants in SETBP1, FANCM, and LSP1 with Familial Breast Cancer in the Pakistani Pashtun Population.",2025,10.12669/pjms.41.9.12324,https://pubmed.ncbi.nlm.nih.gov/41070293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,42380125,Multi-omics analysis in suspected hereditary breast and ovarian cancer cases reveals novel candidate susceptibility factors.,2026,10.1038/s41523-026-01003-1,https://pubmed.ncbi.nlm.nih.gov/42380125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,40447800,Structural basis of Fanconi anemia pathway activation by FANCM.,2025,10.1038/s44318-025-00468-3,https://pubmed.ncbi.nlm.nih.gov/40447800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,40918063,A high-resolution meiotic crossover map from single-nucleus ATAC-seq reveals insights into the recombination landscape in mammals.,2025,10.1093/nargab/lqaf122,https://pubmed.ncbi.nlm.nih.gov/40918063/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,37601968,Fancm has dual roles in the limiting of meiotic crossovers and germ cell maintenance in mammals.,2023,10.1016/j.xgen.2023.100349,https://pubmed.ncbi.nlm.nih.gov/37601968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,39190991,Novel insights into the mechanisms of seasonal cyclicity of testicles by proteomics and transcriptomics analyses in goose breeder lines.,2024,10.1016/j.psj.2024.104213,https://pubmed.ncbi.nlm.nih.gov/39190991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,41881068,Predisposition to ALL and Solid Tumors Rather Than Bone Marrow Failure in &lt;i&gt;FANCM&lt;/i&gt;-Associated Fanconi Anemia.,2026,10.1200/po-25-01089,https://pubmed.ncbi.nlm.nih.gov/41881068/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,40503178,Targeting FANCM using the antisense oligonucleotides to treat the ALT-positive cancers.,2025,10.1016/j.omtn.2025.102558,https://pubmed.ncbi.nlm.nih.gov/40503178/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,40642874,"Recessive FANCM cancer syndrome with high cancer risks, chemotherapy toxicity, chromosome fragility, and gonadal failure.",2025,10.1016/j.gim.2025.101521,https://pubmed.ncbi.nlm.nih.gov/40642874/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,42649894,Real-World Germline Testing Patterns and Clinical Implications of HRR-Associated Germline Variants in Pancreatic Ductal Adenocarcinoma.,2026,10.3390/cancers18162580,https://pubmed.ncbi.nlm.nih.gov/42649894/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,42346589,Genetic Determinants of T-Cell Homeostasis in Critical Illness: An Exploratory Analysis of Immune Gene Variants and TREC Dynamics.,2026,10.3390/jpm16060278,https://pubmed.ncbi.nlm.nih.gov/42346589/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,39838474,RAB3GAP2 dysregulation in adult T-cell leukemia/lymphoma (ATLL) compared to acute lymphoblastic leukemia (ALL): a molecular perspective.,2025,10.1186/s13104-025-07084-8,https://pubmed.ncbi.nlm.nih.gov/39838474/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,40386611,Primary gastric squamous cell carcinoma in a young adult with immunotherapy complications: a case report.,2025,10.21037/jgo-2024-884,https://pubmed.ncbi.nlm.nih.gov/40386611/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,41346410,TSN Disrupts Fanconi Anemia Pathway Activation Through JAK/STAT1-Mediated Transcriptional Repression of FA Core Subunits in Bladder Cancer.,2025,10.1177/15593258251406039,https://pubmed.ncbi.nlm.nih.gov/41346410/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,40344211,Genomic variant profiling in blast-phase paediatric chronic myeloid leukaemia: Predisposing and driving alterations.,2025,10.1111/bjh.20133,https://pubmed.ncbi.nlm.nih.gov/40344211/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,40009290,Population-based study of recurrent DNA damage response gene variants in breast cancer cases.,2025,10.1007/s10549-025-07634-5,https://pubmed.ncbi.nlm.nih.gov/40009290/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,34568721,Ovarian Failure Preceding Head and Neck Squamous Cell Carcinoma Identifies an Adult-Onset Cancer-Prone Syndrome Caused by FANCM Mutations.,2021,10.1200/po.21.00110,https://pubmed.ncbi.nlm.nih.gov/34568721/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,39400928,Comparative sequencing study of mismatch repair and homology-directed repair genes in endometrial cancer and breast cancer patients from Kazakhstan.,2025,10.1002/ijc.35215,https://pubmed.ncbi.nlm.nih.gov/39400928/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,37646306,Angioimmunoblastic T-cell lymphoma: Novel recurrent mutations and prognostic biomarkers by cell-free DNA profiling.,2023,10.1111/bjh.19089,https://pubmed.ncbi.nlm.nih.gov/37646306/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,41465280,Complex Relationships Between Homologous Recombination Deficiency (HRD) Score and Mutational Status of Homologous Recombination Repair (HRR) Genes in Prostate Carcinomas.,2025,10.3390/ijms262411851,https://pubmed.ncbi.nlm.nih.gov/41465280/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,37555818,Mannich Base PIP-199 Is a Chemically Unstable Pan-Assay Interference Compound.,2023,10.1021/acs.jmedchem.3c00674,https://pubmed.ncbi.nlm.nih.gov/37555818/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,39421870,Somatic gene mutations involved in DNA damage response/Fanconi anemia signaling are tissue- and cell-type specific in human solid tumors.,2024,10.3389/fmed.2024.1462810,https://pubmed.ncbi.nlm.nih.gov/39421870/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,30075111,Bi-allelic Recessive Loss-of-Function Variants in FANCM Cause Non-obstructive Azoospermia.,2018,10.1016/j.ajhg.2018.07.005,https://pubmed.ncbi.nlm.nih.gov/30075111/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANCM,ENSG00000187790,Unsafe,29231814,A homozygous FANCM mutation underlies a familial case of non-syndromic primary ovarian insufficiency.,2017,10.7554/elife.30490,https://pubmed.ncbi.nlm.nih.gov/29231814/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,31086747,Normal spermatogenesis in Fank1 (fibronectin type 3 and ankyrin repeat domains 1) mutant mice.,2019,10.7717/peerj.6827,https://pubmed.ncbi.nlm.nih.gov/31086747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,38259468,Pharmacogenomics of intravenous immunoglobulin response in Kawasaki disease.,2023,10.3389/fimmu.2023.1287094,https://pubmed.ncbi.nlm.nih.gov/38259468/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,31373619,"COP9 signalosome complex subunit 5, an IFT20 binding partner, is essential to maintain male germ cell survival and acrosome biogenesis†.",2020,10.1093/biolre/ioz154,https://pubmed.ncbi.nlm.nih.gov/31373619/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,33784512,YAF2 exerts anti-apoptotic effect in human tumor cells in a FANK1- and phosphorylation-dependent manner.,2021,10.1016/j.bbrc.2021.03.105,https://pubmed.ncbi.nlm.nih.gov/33784512/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,37219934,Identification of Distinct Genetic Profiles of Palindromic Rheumatism Using Whole-Exome Sequencing.,2023,10.1002/art.42614,https://pubmed.ncbi.nlm.nih.gov/37219934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,30867990,Transcriptome sequencing and comparative analysis of adult ovary and testis identify potential gonadal maintenance-related genes in Mauremys reevesii with temperature-dependent sex determination.,2019,10.7717/peerj.6557,https://pubmed.ncbi.nlm.nih.gov/30867990/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,35589867,Evaluation of cfDNA as an early detection assay for dense tissue breast cancer.,2022,10.1038/s41598-022-12457-1,https://pubmed.ncbi.nlm.nih.gov/35589867/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,24369145,Testis-specific Fank1 gene in knockdown mice produces oligospermia via apoptosis.,2014,10.4103/1008-682x.122592,https://pubmed.ncbi.nlm.nih.gov/24369145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,29661797,Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium.,2018,10.1242/bio.033944,https://pubmed.ncbi.nlm.nih.gov/29661797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,33819739,Single-cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progression.,2021,10.1016/j.ebiom.2021.103315,https://pubmed.ncbi.nlm.nih.gov/33819739/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,32398127,Promoter methylation changes in ALOX12 and AIRE1: novel epigenetic markers for atherosclerosis.,2020,10.1186/s13148-020-00846-0,https://pubmed.ncbi.nlm.nih.gov/32398127/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,27060496,Proapoptotic RYBP interacts with FANK1 and induces tumor cell apoptosis through the AP-1 signaling pathway.,2016,10.1016/j.cellsig.2016.03.012,https://pubmed.ncbi.nlm.nih.gov/27060496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,26399483,Chromosomal Rearrangements as Barriers to Genetic Homogenization between Archaic and Modern Humans.,2015,10.1093/molbev/msv204,https://pubmed.ncbi.nlm.nih.gov/26399483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,20978819,Fank1 interacts with Jab1 and regulates cell apoptosis via the AP-1 pathway.,2011,10.1007/s00018-010-0559-4,https://pubmed.ncbi.nlm.nih.gov/20978819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,17604233,Fank1 is a testis-specific gene encoding a nuclear protein exclusively expressed during the transition from the meiotic to the haploid phase of spermatogenesis.,2007,10.1016/j.modgep.2007.05.005,https://pubmed.ncbi.nlm.nih.gov/17604233/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,29097723,Genome-wide linkage and association study implicates the 10q26 region as a major genetic contributor to primary nonsyndromic vesicoureteric reflux.,2017,10.1038/s41598-017-15062-9,https://pubmed.ncbi.nlm.nih.gov/29097723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,26548368,DNA hypermethylation of extracellular matrix-related genes in human periodontal fibroblasts induced by stimulation for a prolonged period with lipopolysaccharide derived from Porphyromonas gingivalis.,2016,10.1111/jre.12330,https://pubmed.ncbi.nlm.nih.gov/26548368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,15803458,Specific maternal transcripts in bovine oocytes and cleavaged embryos: identification with novel DDRT-PCR methods.,2005,10.1002/mrd.20282,https://pubmed.ncbi.nlm.nih.gov/15803458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FANK1,ENSG00000203780,Unsafe,18682798,Genes to diseases (G2D) computational method to identify asthma candidate genes.,2008,10.1371/journal.pone.0002907,https://pubmed.ncbi.nlm.nih.gov/18682798/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42883351,N6-Methyladenosine and 5-Methylcytosine Epitranscriptomic Regulation of Male Reproduction and Fertility.,2026,10.3390/biology15191678,https://pubmed.ncbi.nlm.nih.gov/42883351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42294762,Metabolic Adaptation in Acute Ischemic Events: The Critical Role of Acyl-Coenzyme A Synthetase Family in Myocardial Infarction and Ischemic Stroke.,2026,10.1161/jaha.125.047469,https://pubmed.ncbi.nlm.nih.gov/42294762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42432034,SPINK2 in hematopoiesis and cancer: Biology and clinical implications.,2026,10.1038/s41420-026-03206-8,https://pubmed.ncbi.nlm.nih.gov/42432034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42724597,Targeting glutathione peroxidase 4 in ferroptosis: from immune regulation to pharmacological development and translational applications.,2026,10.3389/fphar.2026.1834222,https://pubmed.ncbi.nlm.nih.gov/42724597/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42787258,"ZAK kinase at the crossroads of cellular stress: functional plasticity, human pathobiology, and precision therapeutics.",2026,10.3389/fcell.2026.1909993,https://pubmed.ncbi.nlm.nih.gov/42787258/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42617062,Drosophila beanbag (beba) encodes an insect receptor tyrosine kinase associated with reproductive niche organization.,2026,10.1093/g3journal/jkag227,https://pubmed.ncbi.nlm.nih.gov/42617062/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42883834,The Role of &lt;i&gt;Amh&lt;/i&gt; in Gonadal Development and Its Response to Exogenous Hormones in Blotched Snakehead (&lt;i&gt;Channa maculata&lt;/i&gt;).,2026,10.3390/ijms27198588,https://pubmed.ncbi.nlm.nih.gov/42883834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,40737742,FATE1: A cancer testis antigen with oncogenic functions - Prognostic biomarker and JAK2/STAT1-driven autophagy regulator in breast cancer.,2025,10.1016/j.bbrc.2025.152342,https://pubmed.ncbi.nlm.nih.gov/40737742/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42747955,Protocol for high-sensitivity detection of microRNAs in adult Drosophila tissues using hybridization chain reaction.,2026,10.1016/j.xpro.2026.104840,https://pubmed.ncbi.nlm.nih.gov/42747955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42603290,Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation.,2026,10.1002/advs.77027,https://pubmed.ncbi.nlm.nih.gov/42603290/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42340257,"Signalling through RXRβ and its agonist, bexarotene, promotes neuron formation in Xenopus laevis embryos.",2026,10.1242/bio.062675,https://pubmed.ncbi.nlm.nih.gov/42340257/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42368454,Mechanotransduction in glioma stem cell fate determination: from niche mechanics to therapeutic vulnerability and state plasticity.,2026,10.3389/fcell.2026.1849535,https://pubmed.ncbi.nlm.nih.gov/42368454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42886204,In vivo virus-free lineage tracing and live imaging reveal that NeuroD1 does not reprogram microglia into neurons.,2026,10.7554/elife.112083,https://pubmed.ncbi.nlm.nih.gov/42886204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,41677645,SMG6's PIN (PilT N-Terminus) Domain Is Required for Nonsense-Mediated mRNA Decay (NMD) &lt;i&gt;In Vivo&lt;/i&gt;.,2026,10.3390/cells15030282,https://pubmed.ncbi.nlm.nih.gov/41677645/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42213824,SRSF3 determines T&lt;sub&gt;reg&lt;/sub&gt; cell fate in antitumor immunity and autoimmunity.,2026,10.1126/sciadv.aeh1671,https://pubmed.ncbi.nlm.nih.gov/42213824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42543487,AID-Mediated Protein Knockdown Reveals the Requirement of NANOS2 in Prenatal Gonocytes for Establishing Functional Spermatogonial Stem Cells.,2026,10.1111/dgd.70064,https://pubmed.ncbi.nlm.nih.gov/42543487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42589190,Genome-Wide Identification and Characterization of the &lt;i&gt;Wnt&lt;/i&gt; Gene Family in Donkey (&lt;i&gt;Equus asinus&lt;/i&gt;): Phylogenetic Analysis and Expression Profiling.,2026,10.3390/biology15151323,https://pubmed.ncbi.nlm.nih.gov/42589190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42903334,Engrailed-1 in eccrine sweat gland development and regeneration: from evolutionary innovation to therapeutic perspectives.,2026,10.3389/fcell.2026.1917336,https://pubmed.ncbi.nlm.nih.gov/42903334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42596705,Evolutionary Conservation and Functional Diversification of the Rbm24/38 Family in Metazoans.,2026,10.1002/wrna.70054,https://pubmed.ncbi.nlm.nih.gov/42596705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,41957362,A single-nucleotide enhancer mutation overrides chromosomal sex to drive XX male development.,2026,10.1038/s41467-026-71328-9,https://pubmed.ncbi.nlm.nih.gov/41957362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42688140,"CDK4/6 inhibitors as conditional immune-priming agents in breast cancer: therapeutic windows, sequencing strategies, and rational combinations with immunotherapy, radiotherapy, and antibody-drug conjugates.",2026,10.3389/fimmu.2026.1934879,https://pubmed.ncbi.nlm.nih.gov/42688140/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42717345,Targeting E3 ubiquitin ligases: Mechanistic breakthroughs and novel clinical translation pathways for tumor radioimmunotherapy.,2026,10.1186/s12943-026-02739-x,https://pubmed.ncbi.nlm.nih.gov/42717345/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42347334,Smart Nanomaterials and Natural Biologics for Innate-Adaptive Immune Reprogramming: A Nanobiotechnology Framework for Translational Medicine.,2026,10.3390/nano16120770,https://pubmed.ncbi.nlm.nih.gov/42347334/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42764884,Nanomaterial-mediated functional remodeling of antigen-presenting cells: A novel strategy to break tumor immune escape.,2026,10.1016/j.apsb.2026.06.038,https://pubmed.ncbi.nlm.nih.gov/42764884/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42910276,CHK1 and CHK2 as Context-Dependent Rheostats of Genotoxic Stress: Implications for Cell Fate and Tumor Immunity.,2026,10.7150/ijbs.139580,https://pubmed.ncbi.nlm.nih.gov/42910276/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42711726,"Recent advances in molecular mechanisms to improve the efficacy of CAR-T cell therapy for viral diseases, cancer, and autoimmune diseases.",2026,10.1186/s13287-026-05266-0,https://pubmed.ncbi.nlm.nih.gov/42711726/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42609836,Vγ9Vδ2 T cells in tuberculosis: protective immunity and translational perspectives.,2026,10.3389/fimmu.2026.1884056,https://pubmed.ncbi.nlm.nih.gov/42609836/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42694406,Imaging the fate of CAR-T cells &lt;i&gt;in vivo&lt;/i&gt;.,2026,10.3389/fimmu.2026.1922326,https://pubmed.ncbi.nlm.nih.gov/42694406/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42837695,State-matched redox nanomedicine for cell fate control and multicompartment therapeutic windows.,2026,10.1016/j.redox.2026.104426,https://pubmed.ncbi.nlm.nih.gov/42837695/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42796639,Polysaccharide-Modified Gold Nanorod and Polydopamine Nanocarriers for Near-Infrared Light-Responsive Biomedical Applications: A Comparative Review.,2026,10.3390/molecules31183356,https://pubmed.ncbi.nlm.nih.gov/42796639/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42917227,An NIR-II-Traceable Nanovaccine Programs Systemic Antigen Residence to Establish Checkpoint-Responsive Progenitor-Exhausted CD8-Positive T-Cell Reservoirs for Effective Cancer Immunotherapy.,2026,10.1021/acsnano.6c12073,https://pubmed.ncbi.nlm.nih.gov/42917227/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42689286,Engineered Nanozymes for Colorectal Cancer Therapy: Catalytic Reprogramming of the Tumor Microenvironment.,2026,10.2147/ijn.s640248,https://pubmed.ncbi.nlm.nih.gov/42689286/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42039157,Advances in IL-15-Based Cancer Immunotherapy and Divergent Immunological Effects of IL-2 and IL-15 Signaling via the Shared IL-2Rβγ Receptor.,2026,10.3389/fimmu.2026.1791059,https://pubmed.ncbi.nlm.nih.gov/42039157/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42389526,Fusion protein-mediated costimulation in engineered T cells: from intrinsic signaling to tumor microenvironment rewiring.,2026,10.3389/fimmu.2026.1819470,https://pubmed.ncbi.nlm.nih.gov/42389526/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42382829,"Extracellular vesicles in osteosarcoma: bridging resistance, immunity, and clinical translation.",2026,10.1016/j.jbo.2026.100777,https://pubmed.ncbi.nlm.nih.gov/42382829/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,41930573,T cell fate regulation in EBV‑associated nasopharyngeal carcinoma (Review).,2026,10.3892/or.2026.9111,https://pubmed.ncbi.nlm.nih.gov/41930573/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42471718,"Copper homeostasis and cuproptosis rewire the tumor microenvironment: mechanisms, immune modulation, and therapeutic opportunities.",2026,10.1186/s13045-026-01831-5,https://pubmed.ncbi.nlm.nih.gov/42471718/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42811336,"Cellular senescence and regulated cell death in cancer: mechanisms, cross-regulatory networks and therapeutic implications.",2026,10.1186/s13045-026-01847-x,https://pubmed.ncbi.nlm.nih.gov/42811336/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42582274,Rewriting CAR-T cell fate: CRISPR/Cas gene editing for solid tumor therapy.,2026,10.3389/fimmu.2026.1910092,https://pubmed.ncbi.nlm.nih.gov/42582274/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,42222335,T cell exhaustion landscapes and therapeutic modulation in cancer immunity.,2026,10.3389/fcell.2026.1827716,https://pubmed.ncbi.nlm.nih.gov/42222335/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,12865919,Identification of two novel CT antigens and their capacity to elicit antibody response in hepatocellular carcinoma patients.,2003,10.1038/sj.bjc.6601062,https://pubmed.ncbi.nlm.nih.gov/12865919/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FATE1,ENSG00000147378,Unsafe,11694338,Human FATE is a novel X-linked gene expressed in fetal and adult testis.,2001,10.1016/s0303-7207(01)00666-9,https://pubmed.ncbi.nlm.nih.gov/11694338/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL13,ENSG00000161040,Unsafe,42477522,"Multi-omics integration of F&lt;sub&gt;st&lt;/sub&gt;, GWAS, TWAS and transcriptomics revealed candidate genes and pathways associated with pneumonia lesion scores in pigs.",2026,10.1186/s12864-026-13203-x,https://pubmed.ncbi.nlm.nih.gov/42477522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL13,ENSG00000161040,Unsafe,31961863,Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice.,2020,10.1371/journal.pgen.1008585,https://pubmed.ncbi.nlm.nih.gov/31961863/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL13,ENSG00000161040,Unsafe,38650655,Effects of &lt;i&gt;Tcte1&lt;/i&gt; knockout on energy chain transportation and spermatogenesis: implications for male infertility.,2024,10.1093/hropen/hoae020,https://pubmed.ncbi.nlm.nih.gov/38650655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL13,ENSG00000161040,Unsafe,40509051,Study of the Association Between SNPs and External Pelvimetry Measurements in Romanian Simmental Cattle.,2025,10.3390/ani15111586,https://pubmed.ncbi.nlm.nih.gov/40509051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL13,ENSG00000161040,Unsafe,40341176,OTX2 expression contributes progression of gastric cancer in young adults.,2025,10.1038/s41598-025-99632-2,https://pubmed.ncbi.nlm.nih.gov/40341176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL13,ENSG00000161040,Unsafe,29348145,FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.,2018,10.15252/embr.201744799,https://pubmed.ncbi.nlm.nih.gov/29348145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL13,ENSG00000161040,Unsafe,35023977,Genome-Wide Association Study and Genetic Correlation Scan Provide Insights into Its Genetic Architecture of Sleep Health Score in the UK Biobank Cohort.,2022,10.2147/nss.s326818,https://pubmed.ncbi.nlm.nih.gov/35023977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL13,ENSG00000161040,Unsafe,36718060,Hub Genes and Immune Cell Infiltration in Hypoxia-Induced Pulmonary Hypertension: Bioinformatics Analysis and In Vivo Validation.,2023,10.2174/1386207326666230130093325,https://pubmed.ncbi.nlm.nih.gov/36718060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL13,ENSG00000161040,Unsafe,33428145,Identification of Serum Exosomal MicroRNA Expression Profiling in Menopausal Females with Osteoporosis by High-throughput Sequencing.,2020,10.1007/s11596-020-2306-x,https://pubmed.ncbi.nlm.nih.gov/33428145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL13,ENSG00000161040,Unsafe,25649863,Identifying genetic interactions associated with late-onset Alzheimer's disease.,2014,10.1186/s13040-014-0035-z,https://pubmed.ncbi.nlm.nih.gov/25649863/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL13,ENSG00000161040,Unsafe,29257106,A Genome-Wide Association Study and Complex Network Identify Four Core Hub Genes in Bipolar Disorder.,2017,10.3390/ijms18122763,https://pubmed.ncbi.nlm.nih.gov/29257106/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL13,ENSG00000161040,Unsafe,27889101,Highly heterogeneous genomic landscape of uterine leiomyomas by whole exome sequencing and genome-wide arrays.,2017,10.1016/j.fertnstert.2016.10.035,https://pubmed.ncbi.nlm.nih.gov/27889101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL13,ENSG00000161040,Unsafe,24165912,Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.,2013,10.1161/circgenetics.113.000307,https://pubmed.ncbi.nlm.nih.gov/24165912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,41706863,Tuning of the RBR1-E2F/DP transcriptional module by the F-box protein FBL17.,2026,10.1126/sciadv.adz2439,https://pubmed.ncbi.nlm.nih.gov/41706863/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,39307307,Oxygen-dependent regulation of F-box proteins in Toxoplasma gondii is mediated by Skp1 glycosylation.,2024,10.1016/j.jbc.2024.107801,https://pubmed.ncbi.nlm.nih.gov/39307307/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,35869491,FBXL17/spastin axis as a novel therapeutic target of hereditary spastic paraplegia.,2022,10.1186/s13578-022-00851-1,https://pubmed.ncbi.nlm.nih.gov/35869491/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,41661474,Analysis of genetic mutation characteristics in 40 Chinese patients with hepatocellular carcinoma.,2026,10.1007/s13258-026-01743-1,https://pubmed.ncbi.nlm.nih.gov/41661474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,39504958,Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress.,2024,10.1016/j.cell.2024.10.012,https://pubmed.ncbi.nlm.nih.gov/39504958/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,38302916,Circadian clock-related genome-wide mendelian randomization identifies putatively genes for ulcerative colitis and its comorbidity.,2024,10.1186/s12864-024-10003-z,https://pubmed.ncbi.nlm.nih.gov/38302916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,32414898,The F-Box-Like Protein FBL17 Is a Regulator of DNA-Damage Response and Colocalizes with RETINOBLASTOMA RELATED1 at DNA Lesion Sites.,2020,10.1104/pp.20.00188,https://pubmed.ncbi.nlm.nih.gov/32414898/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,33574575,A novel WEE1 pathway for replication stress responses.,2021,10.1038/s41477-021-00855-8,https://pubmed.ncbi.nlm.nih.gov/33574575/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,31560077,Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation.,2020,10.1007/s00018-019-03306-y,https://pubmed.ncbi.nlm.nih.gov/31560077/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,34573389,Common and Unique Genetic Background between Attention-Deficit/Hyperactivity Disorder and Excessive Body Weight.,2021,10.3390/genes12091407,https://pubmed.ncbi.nlm.nih.gov/34573389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,34838041,A two-stage genome-wide association study of radiation-induced acute toxicity in head and neck cancer.,2021,10.1186/s12967-021-03145-1,https://pubmed.ncbi.nlm.nih.gov/34838041/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,33204104,A Novel ROS1-FBXL17 Fusion Co-Existing with CD74-ROS1 Fusion May Improve Sensitivity to Crizotinib and Prolong Progression-Free Survival of Patients with Lung Adenocarcinoma.,2020,10.2147/ott.s278907,https://pubmed.ncbi.nlm.nih.gov/33204104/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,32814905,Structural basis for dimerization quality control.,2020,10.1038/s41586-020-2636-7,https://pubmed.ncbi.nlm.nih.gov/32814905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,35165267,Genetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans.,2022,10.1038/s41467-022-28276-x,https://pubmed.ncbi.nlm.nih.gov/35165267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,27234298,SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.,2016,10.15252/embj.201593374,https://pubmed.ncbi.nlm.nih.gov/27234298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,28883095,Lipopolysaccharide modulates p300 and Sirt1 to promote PRMT1 stability via an SCFFbxl17-recognized acetyldegron.,2017,10.1242/jcs.206904,https://pubmed.ncbi.nlm.nih.gov/28883095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,36626244,Profiling of a novel circadian clock-related prognostic signature and its role in immune function and response to molecular targeted therapy in pancreatic cancer.,2023,10.18632/aging.204462,https://pubmed.ncbi.nlm.nih.gov/36626244/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,25944099,The Control of Arabidopsis thaliana Growth by Cell Proliferation and Endoreplication Requires the F-Box Protein FBL17.,2015,10.1105/tpc.114.135301,https://pubmed.ncbi.nlm.nih.gov/25944099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,33130294,Host genetics influences the relationship between the gut microbiome and psychiatric disorders.,2021,10.1016/j.pnpbp.2020.110153,https://pubmed.ncbi.nlm.nih.gov/33130294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXL17,ENSG00000145743,Unsafe,28007836,Single Locus Maintains Large Variation of Sex Reversal in Half-Smooth Tongue Sole (Cynoglossus semilaevis).,2017,10.1534/g3.116.036822,https://pubmed.ncbi.nlm.nih.gov/28007836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,41999223,H3K27me3 Modified FBXO10 Promotes Golgi Stress to Accelerate Traumatic Brain Injury via Activation of the RAS/ERK Axis.,2026,10.1096/fj.202503776rr,https://pubmed.ncbi.nlm.nih.gov/41999223/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,42567455,F-box only protein 10 protects against pathological myocardial hypertrophy by counteracting ferroptotic cell death in cardiomyocytes via destabilization of ACSL4.,2026,10.1016/j.taap.2026.117987,https://pubmed.ncbi.nlm.nih.gov/42567455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,42819184,Integrative multi-omics analysis unveils the regulatory landscape of diabetic cardiomyopathy: from chromatin accessibility to transcript isoforms and epitranscriptome.,2026,10.3389/fendo.2026.1928778,https://pubmed.ncbi.nlm.nih.gov/42819184/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,40699790,FBXO10 Drives Hepatocellular Carcinoma Proliferation via K63-Linked Ubiquitination and Stabilization of FRMPD1.,2025,10.3390/cimb47060391,https://pubmed.ncbi.nlm.nih.gov/40699790/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,40616744,FBXO10 inhibits ferroptosis and promotes the progression of esophageal squamous cell carcinoma by post-translational mediation of ACSL4 degradation.,2025,10.1007/s10735-025-10497-1,https://pubmed.ncbi.nlm.nih.gov/40616744/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,42009969,Thr3/Ser90 phosphorylation-stabilized S100A8 regulates cholesterol metabolism in glioblastoma stem cells.,2026,10.1038/s41388-026-03799-5,https://pubmed.ncbi.nlm.nih.gov/42009969/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,39306844,Geranylgeranylated SCFFBXO10 regulates selective outer mitochondrial membrane proteostasis and function.,2024,10.1016/j.celrep.2024.114783,https://pubmed.ncbi.nlm.nih.gov/39306844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,40050614,HAT1/HDAC2 mediated ACSL4 acetylation confers radiosensitivity by inducing ferroptosis in nasopharyngeal carcinoma.,2025,10.1038/s41419-025-07477-4,https://pubmed.ncbi.nlm.nih.gov/40050614/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,34492157,FBXO10 prevents chronic unpredictable stress-induced behavioral despair and cognitive impairment through promoting RAGE degradation.,2021,10.1111/cns.13727,https://pubmed.ncbi.nlm.nih.gov/34492157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,34244497,Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury.,2021,10.1038/s41467-021-24469-y,https://pubmed.ncbi.nlm.nih.gov/34244497/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,33914737,"Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice.",2021,10.1371/journal.pone.0237830,https://pubmed.ncbi.nlm.nih.gov/33914737/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,38205686,Melatonin alleviates ischemic stroke by inhibiting ferroptosis through the CYP1B1/ACSL4 pathway.,2024,10.1002/tox.24136,https://pubmed.ncbi.nlm.nih.gov/38205686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,38867047,Genetic drivers and cellular selection of female mosaic X chromosome loss.,2024,10.1038/s41586-024-07533-7,https://pubmed.ncbi.nlm.nih.gov/38867047/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,37059712,CYP1B1 inhibits ferroptosis and induces anti-PD-1 resistance by degrading ACSL4 in colorectal cancer.,2023,10.1038/s41419-023-05803-2,https://pubmed.ncbi.nlm.nih.gov/37059712/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,37011862,Heat shock protein 90 facilitates SARS-CoV-2 structural protein-mediated virion assembly and promotes virus-induced pyroptosis.,2023,10.1016/j.jbc.2023.104668,https://pubmed.ncbi.nlm.nih.gov/37011862/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,34278484,Whole‑genome identification and systematic analysis of lncRNA‑mRNA co‑expression profiles in patients with cutaneous basal cell carcinoma.,2021,10.3892/mmr.2021.12270,https://pubmed.ncbi.nlm.nih.gov/34278484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,26187670,FBXO11 represses cellular response to hypoxia by destabilizing hypoxia-inducible factor-1α mRNA.,2015,10.1016/j.bbrc.2015.07.037,https://pubmed.ncbi.nlm.nih.gov/26187670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,35910206,Analysis of Competitive Endogenous Mechanism and Survival Prognosis of Serum Exosomes in Ovarian Cancer Patients Based on Sequencing Technology and Bioinformatics.,2022,10.3389/fgene.2022.850089,https://pubmed.ncbi.nlm.nih.gov/35910206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,24008983,Differential 12-O-Tetradecanoylphorbol-13-acetate-induced activation of rat mammary carcinoma susceptibility Fbxo10 variant promoters via a PKC-AP1 pathway.,2015,10.1002/mc.22081,https://pubmed.ncbi.nlm.nih.gov/24008983/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,27157620,FBXO10 deficiency and BTK activation upregulate BCL2 expression in mantle cell lymphoma.,2016,10.1038/onc.2016.155,https://pubmed.ncbi.nlm.nih.gov/27157620/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,32545767,Well-Differentiated Papillary Mesothelioma of the Peritoneum Is Genetically Distinct from Malignant Mesothelioma.,2020,10.3390/cancers12061568,https://pubmed.ncbi.nlm.nih.gov/32545767/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,23431138,Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma.,2013,10.1073/pnas.1217271110,https://pubmed.ncbi.nlm.nih.gov/23431138/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,23138933,Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF).,2014,10.1002/mc.21977,https://pubmed.ncbi.nlm.nih.gov/23138933/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,25786224,Novel genetic locus implicated for HIV-1 acquisition with putative regulatory links to HIV replication and infectivity: a genome-wide association study.,2015,10.1371/journal.pone.0118149,https://pubmed.ncbi.nlm.nih.gov/25786224/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,21914726,An insulator loop resides between the synthetically interacting elements of the human/rat conserved breast cancer susceptibility locus MCS5A/Mcs5a.,2012,10.1093/nar/gkr610,https://pubmed.ncbi.nlm.nih.gov/21914726/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO10,ENSG00000147912,Unsafe,21846333,The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions.,2011,10.1186/bcr2933,https://pubmed.ncbi.nlm.nih.gov/21846333/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,41626181,Identify and validate a novel ubiquitination-related biomarker for thyroid cancer prognosis and immunotherapy.,2025,10.3389/fonc.2025.1542784,https://pubmed.ncbi.nlm.nih.gov/41626181/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,41268268,F-box in breast cancer: mechanism of action and therapeutic potential.,2025,10.62347/devn4395,https://pubmed.ncbi.nlm.nih.gov/41268268/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,41401169,Diagnostic yield of exome sequencing in nonobstructive azoospermia (NOA): A systematic review and meta-analysis.,2025,10.1371/journal.pone.0338892,https://pubmed.ncbi.nlm.nih.gov/41401169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,39541666,Gastrodin reduces Aβ brain levels in an Alzheimer's disease mouse model by inhibiting P-glycoprotein ubiquitination.,2024,10.1016/j.phymed.2024.156229,https://pubmed.ncbi.nlm.nih.gov/39541666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,40457403,Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania.,2025,10.1186/s12920-025-02164-x,https://pubmed.ncbi.nlm.nih.gov/40457403/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,34083507,FBXO15 plays a critical suppressive functional role in regulation of breast cancer progression.,2021,10.1038/s41392-021-00605-4,https://pubmed.ncbi.nlm.nih.gov/34083507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,33159144,Oroxylin A alleviates immunoparalysis of CLP mice by degrading CHOP through interacting with FBXO15.,2020,10.1038/s41598-020-76285-x,https://pubmed.ncbi.nlm.nih.gov/33159144/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,27786305,RSK1 protects P-glycoprotein/ABCB1 against ubiquitin-proteasomal degradation by downregulating the ubiquitin-conjugating enzyme E2 R1.,2016,10.1038/srep36134,https://pubmed.ncbi.nlm.nih.gov/27786305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,34982428,The protective effect of Metformin/Donepezil in diabetic mice brain: evidence from bioinformatics analysis and experiments.,2021,10.26355/eurrev_202112_27613,https://pubmed.ncbi.nlm.nih.gov/34982428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,27649508,"SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus.",2016,10.1371/journal.ppat.1005899,https://pubmed.ncbi.nlm.nih.gov/27649508/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,34201347,A Novel Signature of CCNF-Associated E3 Ligases Collaborate and Counter Each Other in Breast Cancer.,2021,10.3390/cancers13122873,https://pubmed.ncbi.nlm.nih.gov/34201347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,23465077,FBXO15 regulates P-glycoprotein/ABCB1 expression through the ubiquitin--proteasome pathway in cancer cells.,2013,10.1111/cas.12145,https://pubmed.ncbi.nlm.nih.gov/23465077/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,32302560,Developmental IL-6 Exposure Favors Production of PDGF-Responsive Multipotential Progenitors at the Expense of Neural Stem Cells and Other Progenitors.,2020,10.1016/j.stemcr.2020.03.019,https://pubmed.ncbi.nlm.nih.gov/32302560/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,34347012,Ubiquitination-Related miRNA-mRNA Interaction Is a Potential Mechanism in the Progression of Retinoblastoma.,2021,10.1167/iovs.62.10.3,https://pubmed.ncbi.nlm.nih.gov/34347012/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,24703837,E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia.,2014,10.1016/j.celrep.2014.02.048,https://pubmed.ncbi.nlm.nih.gov/24703837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,28319092,The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells.,2017,10.1038/ncb3491,https://pubmed.ncbi.nlm.nih.gov/28319092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,37249397,Evaluation of Genetic and Nongenetic Risk Factors for Degenerative Cervical Myelopathy.,2023,10.1097/brs.0000000000004735,https://pubmed.ncbi.nlm.nih.gov/37249397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,12665572,Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development.,2003,10.1128/mcb.23.8.2699-2708.2003,https://pubmed.ncbi.nlm.nih.gov/12665572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,23408906,A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.,2013,10.1371/journal.pgen.1003266,https://pubmed.ncbi.nlm.nih.gov/23408906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO15,ENSG00000141665,Unsafe,17554338,Generation of germline-competent induced pluripotent stem cells.,2007,10.1038/nature05934,https://pubmed.ncbi.nlm.nih.gov/17554338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,42801694,"GNAS-AS1 Promotes M2-Like Macrophage Polarization, Contributing to Cervical Cancer Growth, Angiogenesis, and Metastasis Through the miR-518c-5p/FBXO38 Axis and MAPK Signaling.",2026,10.1002/mc.70110,https://pubmed.ncbi.nlm.nih.gov/42801694/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,41546764,Chebulagic acid targets FBXO38 to enhance natural killer cell-mediated anti-tumor immunity in lung adenocarcinoma.,2026,10.1007/s13577-026-01347-7,https://pubmed.ncbi.nlm.nih.gov/41546764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,40313652,FBXO38 Regulates Nox1 Stability to Reduce Vascular Endothelial Damage Induced by Low Oscillatory Shear Stress.,2025,10.1155/cdr/4506032,https://pubmed.ncbi.nlm.nih.gov/40313652/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,39469623,Identification and experimental validation of hub genes underlying depressive-like behaviors induced by chronic social defeat stress.,2024,10.3389/fphar.2024.1472468,https://pubmed.ncbi.nlm.nih.gov/39469623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,40798880,Overlap between COPD genetic association results and transcriptional quantitative trait loci.,2026,10.1016/j.xhgg.2025.100493,https://pubmed.ncbi.nlm.nih.gov/40798880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,39294504,Cytoplasmic FBXO38 mediates PD-1 degradation.,2024,10.1038/s44319-024-00254-y,https://pubmed.ncbi.nlm.nih.gov/39294504/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,38990095,The E3 Ubiquitin Ligase FBXO38 Maintains the Antitumor Function of Natural Killer Cells by Sustaining IL15R Signaling.,2024,10.1158/2326-6066.cir-23-1061,https://pubmed.ncbi.nlm.nih.gov/38990095/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,37821621,FBXO38 regulates macrophage polarization to control the development of cancer and colitis.,2023,10.1038/s41423-023-01081-2,https://pubmed.ncbi.nlm.nih.gov/37821621/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,39266770,FBXO38 is dispensable for PD-1 regulation.,2024,10.1038/s44319-024-00220-8,https://pubmed.ncbi.nlm.nih.gov/39266770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,39116343,PTBP3 Mediates IL-18 Exon Skipping to Promote Immune Escape in Gallbladder Cancer.,2024,10.1002/advs.202406633,https://pubmed.ncbi.nlm.nih.gov/39116343/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,38277817,FBXO38 deficiency promotes lysosome-dependent STING degradation and inhibits cGAS-STING pathway activation.,2024,10.1016/j.neo.2024.100973,https://pubmed.ncbi.nlm.nih.gov/38277817/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,35769260,FBXO38 Ubiquitin Ligase Controls Sertoli Cell Maturation.,2022,10.3389/fcell.2022.914053,https://pubmed.ncbi.nlm.nih.gov/35769260/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,37161806,[Effects of herbal cake separated moxibustion on Tim-4 and ubiquitination of PD-1 in rabbits with immunosuppression].,2023,10.13703/j.0255-2930.20220216-k0001,https://pubmed.ncbi.nlm.nih.gov/37161806/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,38759092,Large-Scale Alternative Polyadenylation-Wide Association Studies to Identify Putative Cancer Susceptibility Genes.,2024,10.1158/0008-5472.can-24-0521,https://pubmed.ncbi.nlm.nih.gov/38759092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,35813202,FBXO38 Ubiquitin Ligase Controls Centromere Integrity via ZXDA/B Stability.,2022,10.3389/fcell.2022.929288,https://pubmed.ncbi.nlm.nih.gov/35813202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,36654786,Disruption of CISH promotes the antitumor activity of human T cells and decreases PD-1 expression levels.,2023,10.1016/j.omto.2022.12.003,https://pubmed.ncbi.nlm.nih.gov/36654786/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,31269066,Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene.,2019,10.1371/journal.pgen.1008229,https://pubmed.ncbi.nlm.nih.gov/31269066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,35633411,Tumor-derived IL-8 facilitates lymph node metastasis of gastric cancer via PD-1 up-regulation in CD8+ T cells.,2022,10.1007/s00262-022-03223-3,https://pubmed.ncbi.nlm.nih.gov/35633411/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,30804394,USP7 Regulates Cytokinesis through FBXO38 and KIF20B.,2019,10.1038/s41598-019-39368-y,https://pubmed.ncbi.nlm.nih.gov/30804394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,37735597,Defining E3 ligase-substrate relationships through multiplex CRISPR screening.,2023,10.1038/s41556-023-01229-2,https://pubmed.ncbi.nlm.nih.gov/37735597/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,37938970,FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation.,2023,10.1016/j.celrep.2023.113362,https://pubmed.ncbi.nlm.nih.gov/37938970/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,30609969,FBXO38 Drives PD-1 to Destruction.,2019,10.1016/j.it.2018.12.005,https://pubmed.ncbi.nlm.nih.gov/30609969/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,30487606,FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.,2018,10.1038/s41586-018-0756-0,https://pubmed.ncbi.nlm.nih.gov/30487606/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO38,ENSG00000145868,Unsafe,34103343,"Improving the efficacy of exome sequencing at a quaternary care referral centre: novel mutations, clinical presentations and diagnostic challenges in rare neurogenetic diseases.",2021,10.1136/jnnp-2020-325437,https://pubmed.ncbi.nlm.nih.gov/34103343/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,42343437,FBXO5 regulates RPL23A to promote MDM2-mediated p53 degradation and facilitate malignant progression of breast cancer.,2026,10.1186/s13058-026-02335-3,https://pubmed.ncbi.nlm.nih.gov/42343437/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,42315647,CD8 T lymphocytes deploy embryonic cell cycle control mechanisms for rapid cell proliferation.,2026,10.1038/s44319-026-00830-4,https://pubmed.ncbi.nlm.nih.gov/42315647/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,41240879,FBXO5 alleviates apical periodontitis by facilitating TP53 protein degradation.,2026,10.1016/j.identj.2025.103948,https://pubmed.ncbi.nlm.nih.gov/41240879/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,41234846,FBXO5 drives hepatocellular carcinoma progression and is a target for tea polyphenol-mediated inhibition.,2025,10.21037/tcr-2025-1462,https://pubmed.ncbi.nlm.nih.gov/41234846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,42547832,"A VIM2/4 deletion, and premature truncations of CMT2 and FBX5, drive DNA methylation changes after colonization of a novel habitat.",2026,10.1038/s41477-026-02352-2,https://pubmed.ncbi.nlm.nih.gov/42547832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,41250776,CircUSP36 promotes FBXO5 expression to accelerate cervical cancer progression by targeting miR-520d-5p.,2025,10.1007/s10616-025-00852-1,https://pubmed.ncbi.nlm.nih.gov/41250776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,42374998,EXPRESSION OF CONCERN: An Upstream Open Reading Frame Regulates Vasculogenic Mimicry of Glioma via ZNRD1-AS1/miR-499a-5p/ELF1/EMI1 Pathway.,2026,10.1111/jcmm.71268,https://pubmed.ncbi.nlm.nih.gov/42374998/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,40775408,Integrative analysis identifies FBXO5 as a critical mediator of CRPC progression and bone metastatic potential.,2025,10.1007/s12672-025-03069-y,https://pubmed.ncbi.nlm.nih.gov/40775408/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,40577599,NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β-TrCP1/FBXO5 Axis.,2025,10.1002/advs.202500798,https://pubmed.ncbi.nlm.nih.gov/40577599/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,39714552,Role of arbutin in the inhibition of FBXO5 in hepatocellular carcinoma.,2024,10.1007/s12672-024-01729-z,https://pubmed.ncbi.nlm.nih.gov/39714552/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,39057099,Downregulation of Splicing Factor PTBP1 Curtails FBXO5 Expression to Promote Cellular Senescence in Lung Adenocarcinoma.,2024,10.3390/cimb46070458,https://pubmed.ncbi.nlm.nih.gov/39057099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,41045986,Targeting the FBXO5-DOK6 axis to overcome temozolomide resistance in glioblastoma via proteasome-cytomechanics regulation.,2025,10.1016/j.canlet.2025.218072,https://pubmed.ncbi.nlm.nih.gov/41045986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,41467813,Thalidomide Synergistically Regulates Cell Cycle and Endoplasmic Reticulum Stress to Alleviate RPE Oxidative Damage Through the E2F2-FBXO5 Pathway.,2026,10.1096/fj.202502444r,https://pubmed.ncbi.nlm.nih.gov/41467813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,40378113,"CPI203, a BET inhibitor, down-regulates a consistent set of DNA synthesis genes across a wide array of glioblastoma lines.",2025,10.1371/journal.pone.0306846,https://pubmed.ncbi.nlm.nih.gov/40378113/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,39061113,METTL16 regulates the mRNA stability of FBXO5 via m6A modification to facilitate the malignant behavior of breast cancer.,2024,10.1186/s40170-024-00351-5,https://pubmed.ncbi.nlm.nih.gov/39061113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,38212299,FBXO5-mediated RNF183 degradation prevents endoplasmic reticulum stress-induced apoptosis and promotes colon cancer progression.,2024,10.1038/s41419-024-06421-2,https://pubmed.ncbi.nlm.nih.gov/38212299/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,39358461,Loss of EMI1 compromises chromosome stability and is associated with cellular transformation in colonic epithelial cell contexts.,2024,10.1038/s41416-024-02855-9,https://pubmed.ncbi.nlm.nih.gov/39358461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,41420753,Differential Gene Expression Across Species Following Spinal Cord Injury: A Systematic Review and Meta-Analysis.,2025,10.1007/s12035-025-05496-y,https://pubmed.ncbi.nlm.nih.gov/41420753/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,37168048,"Expression significance of Emi1, UBCH10 and CyclinB1 in esophageal squamous cell carcinoma.",2023,10.3389/pore.2023.1611081,https://pubmed.ncbi.nlm.nih.gov/37168048/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,39567505,Cryo-EM structures of apo-APC/C and APC/CCDH1:EMI1 complexes provide insights into APC/C regulation.,2024,10.1038/s41467-024-54398-5,https://pubmed.ncbi.nlm.nih.gov/39567505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,35720327,Prognostic Significance and Immunological Role of FBXO5 in Human Cancers: A Systematic Pan-Cancer Analysis.,2022,10.3389/fimmu.2022.901784,https://pubmed.ncbi.nlm.nih.gov/35720327/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,37859622,Licochalcone A induces cell cycle arrest and apoptosis via suppressing MAPK signaling pathway and the expression of FBXO5 in lung squamous cell cancer.,2023,10.3892/or.2023.8651,https://pubmed.ncbi.nlm.nih.gov/37859622/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,39687194,Interspecies transcriptome profiles of human T cell activation and liver inflammation in a xenogeneic graft-versus-host disease model.,2024,10.1016/j.heliyon.2024.e40559,https://pubmed.ncbi.nlm.nih.gov/39687194/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,36037385,Adaptive exchange sustains cullin-RING ubiquitin ligase networks and proper licensing of DNA replication.,2022,10.1073/pnas.2205608119,https://pubmed.ncbi.nlm.nih.gov/36037385/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,37073955,Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells.,2023,10.7554/elife.80254,https://pubmed.ncbi.nlm.nih.gov/37073955/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,36170228,Gene expression profiling identifies candidate biomarkers for new latent tuberculosis infections. A cohort study.,2022,10.1371/journal.pone.0274257,https://pubmed.ncbi.nlm.nih.gov/36170228/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,33822486,The FBXW7-NOTCH interactome: A ubiquitin proteasomal system-induced crosstalk modulating oncogenic transformation in human tissues.,2021,10.1002/cnr2.1369,https://pubmed.ncbi.nlm.nih.gov/33822486/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,33536540,Detection of selection signatures for response to Aleutian mink disease virus infection in American mink.,2021,10.1038/s41598-021-82522-8,https://pubmed.ncbi.nlm.nih.gov/33536540/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,27347110,Enhanced expression of early mitotic inhibitor-1 predicts a poor prognosis in esophageal squamous cell carcinoma patients.,2016,10.3892/ol.2016.4611,https://pubmed.ncbi.nlm.nih.gov/27347110/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,33622332,Systematic analysis of the expression and prognosis relevance of FBXO family reveals the significance of FBXO1 in human breast cancer.,2021,10.1186/s12935-021-01833-y,https://pubmed.ncbi.nlm.nih.gov/33622332/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FBXO5,ENSG00000112029,Unsafe,34262130,CRIP1 cooperates with BRCA2 to drive the nuclear enrichment of RAD51 and to facilitate homologous repair upon DNA damage induced by chemotherapy.,2021,10.1038/s41388-021-01932-0,https://pubmed.ncbi.nlm.nih.gov/34262130/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FER1L6,ENSG00000214814,Unsafe,41692868,Laboratory and genetic characteristic associated with gallbladder-related outcomes in sickle cell disease in Brazil: results from the REDS-III multicenter cohort study.,2026,10.1007/s00277-026-06800-z,https://pubmed.ncbi.nlm.nih.gov/41692868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FER1L6,ENSG00000214814,Unsafe,37538852,Otoferlin as a multirole Ca2+ signaling protein: from inner ear synapses to cancer pathways.,2023,10.3389/fncel.2023.1197611,https://pubmed.ncbi.nlm.nih.gov/37538852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FER1L6,ENSG00000214814,Unsafe,36696506,"Testis-enriched ferlin, FER1L5, is required for Ca&lt;sup&gt;2+&lt;/sup&gt;-activated acrosome reaction and male fertility.",2023,10.1126/sciadv.ade7607,https://pubmed.ncbi.nlm.nih.gov/36696506/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FER1L6,ENSG00000214814,Unsafe,35385957,[Preliminary study on the diagnostic value of serum-derived exosomal lncRNA in epithelial ovarian cancer].,2022,10.3760/cma.j.cn112141-20220114-00022,https://pubmed.ncbi.nlm.nih.gov/35385957/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FER1L6,ENSG00000214814,Unsafe,37808112,"Transcriptome profiling in rumen, reticulum, omasum, and abomasum tissues during the developmental transition of pre-ruminant to the ruminant in yaks.",2023,10.3389/fvets.2023.1204706,https://pubmed.ncbi.nlm.nih.gov/37808112/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FER1L6,ENSG00000214814,Unsafe,38745021,Transcriptomic characteristics according to tumor size and SUVmax in papillary thyroid cancer patients.,2024,10.1038/s41598-024-61839-0,https://pubmed.ncbi.nlm.nih.gov/38745021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FER1L6,ENSG00000214814,Unsafe,30516436,Fer1l6 is essential for the development of vertebrate muscle tissue in zebrafish.,2019,10.1091/mbc.e18-06-0401,https://pubmed.ncbi.nlm.nih.gov/30516436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FER1L6,ENSG00000214814,Unsafe,35957660,Three new genes associated with longevity in the European Bison.,2022,10.1016/j.vas.2022.100266,https://pubmed.ncbi.nlm.nih.gov/35957660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FER1L6,ENSG00000214814,Unsafe,31985086,Gastric-type gene expression and phenotype in non-terminal respiratory unit type adenocarcinoma of the lung with invasive mucinous adenocarcinoma morphology.,2020,10.1111/his.14077,https://pubmed.ncbi.nlm.nih.gov/31985086/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FER1L6,ENSG00000214814,Unsafe,35901179,Redefining the architecture of ferlin proteins: Insights into multi-domain protein structure and function.,2022,10.1371/journal.pone.0270188,https://pubmed.ncbi.nlm.nih.gov/35901179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FER1L6,ENSG00000214814,Unsafe,33109206,Identification of potential causal variants for premature ovarian failure by whole exome sequencing.,2020,10.1186/s12920-020-00813-x,https://pubmed.ncbi.nlm.nih.gov/33109206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FER1L6,ENSG00000214814,Unsafe,29643985,Replication-incompetent gammaretroviral and lentiviral vector-based insertional mutagenesis screens identify prostate cancer progression genes.,2018,10.18632/oncotarget.24503,https://pubmed.ncbi.nlm.nih.gov/29643985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FER1L6,ENSG00000214814,Unsafe,26707827,Ferlins Show Tissue-Specific Expression and Segregate as Plasma Membrane/Late Endosomal or Trans-Golgi/Recycling Ferlins.,2016,10.1111/tra.12370,https://pubmed.ncbi.nlm.nih.gov/26707827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,41219904,Metabolic sexual dimorphism in hypothalamic Fezf1 neuron-specific BDNF knockout.,2025,10.1186/s13293-025-00770-z,https://pubmed.ncbi.nlm.nih.gov/41219904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,40778223,FEZF1-AS1 drives autophagy-mediated progression of colon cancer and reduces chemosensitivity through inhabiting the PI3K/AKT/mTOR signaling pathway.,2025,10.3389/fgene.2025.1514205,https://pubmed.ncbi.nlm.nih.gov/40778223/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,41331461,LncRNA FEZF1-AS1 regulates the gene expression and alternative splicing associated with osteosarcoma.,2025,10.1186/s13018-025-06357-z,https://pubmed.ncbi.nlm.nih.gov/41331461/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,41085851,Long non-coding RNA FEZF1-AS1 suppresses ferroptosis in multiple myeloma cells through KIAA1429-mediated m6A modification.,2025,10.1007/s13577-025-01274-z,https://pubmed.ncbi.nlm.nih.gov/41085851/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,41073638,LncRNA FEZF1-AS1 promotes the tumorigenesis and suppresses ferroptosis in non-small cell lung cancer through the TNF-α/NF-κB pathway.,2026,10.1007/s12094-025-04071-0,https://pubmed.ncbi.nlm.nih.gov/41073638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,39472569,LncRNA FEZF1-AS1 promotes pulmonary fibrosis via up-regulating EZH2 and targeting miR-200c-3p to regulate the ZEB1 pathway.,2024,10.1038/s41598-024-74570-7,https://pubmed.ncbi.nlm.nih.gov/39472569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,39005663,LncRNA FEZF1-AS1 facilitates cisplatin resistance in non-small cell lung cancer through modulating the miR-32-5p-glutaminase axis.,2024,10.62347/wukn6549,https://pubmed.ncbi.nlm.nih.gov/39005663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,40537980,A novel non-invasive mRNA-lncRNA biomarker panel for accurate prediction of cervical squamous cell carcinoma and adenocarcinoma.,2025,10.3802/jgo.2025.36.e81,https://pubmed.ncbi.nlm.nih.gov/40537980/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,39503758,The Role of lncRNA FEZF1-AS1 in Colorectal Cancer Progression Via the P53 Signaling Pathway.,2025,10.1089/dna.2024.0184,https://pubmed.ncbi.nlm.nih.gov/39503758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,37872600,Preeclampsia-associated lncRNA FEZF1-AS1 regulates cell proliferation and apoptosis in placental trophoblast cells through the ELAVL1/NOC2L axis.,2023,10.1186/s13008-023-00101-x,https://pubmed.ncbi.nlm.nih.gov/37872600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,40869924,Gene-by-Environment Interactions Involving Maternal Exposures with Orofacial Cleft Risk in Filipinos.,2025,10.3390/genes16080876,https://pubmed.ncbi.nlm.nih.gov/40869924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,38862441,[Overexpression of lncRNA FEZF1-AS1 promotes progression of non-small cell lung cancer via the miR-130a-5p/CCND1 axis].,2024,10.12122/j.issn.1673-4254.2024.05.05,https://pubmed.ncbi.nlm.nih.gov/38862441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,37364417,"Up-regulation of BOK-AS1, FAM215A and FEZF1-AS1 lncRNAs and their potency as moderate diagnostic biomarkers in gastric cancer.",2023,10.1016/j.prp.2023.154639,https://pubmed.ncbi.nlm.nih.gov/37364417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,40428373,Statistical Analysis of Reproductive Traits in Jinwu Pig and Identification of Genome-Wide Association Loci.,2025,10.3390/genes16050550,https://pubmed.ncbi.nlm.nih.gov/40428373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,38702606,Unraveling the genetic architecture of blood unfolded p-53 among non-demented elderlies: novel candidate genes for early Alzheimer's disease.,2024,10.1186/s12864-024-10363-6,https://pubmed.ncbi.nlm.nih.gov/38702606/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,39073683,The role of EZH2 and its regulatory lncRNAs as a serum-based biomarker in Alzheimer's disease.,2024,10.1007/s11033-024-09802-0,https://pubmed.ncbi.nlm.nih.gov/39073683/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,41405758,Identification of novel ceRNA networks associated with system hemostasis and their prognostic implication in lung squamous cell carcinoma.,2026,10.1007/s11239-025-03218-8,https://pubmed.ncbi.nlm.nih.gov/41405758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,41103242,Integrative Transcriptomic and Metabolomic Analysis Reveals Aberrant Glycosylation as a Hallmark of Lung Adenocarcinoma.,2025,10.1177/15578100251387518,https://pubmed.ncbi.nlm.nih.gov/41103242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,37125488,LncRNA FEZF1-AS1 accelerates multiple myeloma progression by regulating IGF2BP1/BZW2 signaling.,2023,10.1002/hon.3157,https://pubmed.ncbi.nlm.nih.gov/37125488/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,29348628,FEZF1-AS1/miR-107/ZNF312B axis facilitates progression and Warburg effect in pancreatic ductal adenocarcinoma.,2018,10.1038/s41419-017-0052-1,https://pubmed.ncbi.nlm.nih.gov/29348628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,35607960,Long non-coding RNA FEZF1-AS1 promotes rectal cancer progression by competitively binding miR-632 with FAM83A.,2022,10.3724/abbs.2022022,https://pubmed.ncbi.nlm.nih.gov/35607960/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,36987411,Lncrna FEZf1-as1 negatively regulates ETNK1 to promote malignant progression of renal cell carcinoma.,2023,10.5937/jomb0-39710,https://pubmed.ncbi.nlm.nih.gov/36987411/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,34877908,RETRACTED ARTICLE: Down-regulation of lncRNA FEZF1-AS1 mediates regulatory T cell differentiation and further blocks immune escape in colon cancer.,2022,10.1080/14737159.2022.2012157,https://pubmed.ncbi.nlm.nih.gov/34877908/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,37792268,Exploring the Therapeutic Potential of Fe3O4@Glu-Oleuropein Nanoparticles in Targeting KRAS Pathway-Regulating lncRNAs in Colorectal Cancer Cells.,2024,10.1007/s12011-023-03892-w,https://pubmed.ncbi.nlm.nih.gov/37792268/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,32901841,"lncRNA FEZF1‑AS1 promotes migration, invasion and epithelial‑mesenchymal transition of retinoblastoma cells by targeting miR‑1236‑3p.",2020,10.3892/mmr.2020.11478,https://pubmed.ncbi.nlm.nih.gov/32901841/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,30410597,FEZF1 is an Independent Predictive Factor for Recurrence and Promotes Cell Proliferation and Migration in Cervical Cancer.,2018,10.7150/jca.26073,https://pubmed.ncbi.nlm.nih.gov/30410597/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,29709443,Upregulation of LncRNA FEZF-AS1 is associated with advanced clinical stages and family history of cancer in patients with NSCLC.,2018,10.1016/j.prp.2018.04.014,https://pubmed.ncbi.nlm.nih.gov/29709443/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,32020063,Long non-coding RNA dysregulation is a frequent event in non-small cell lung carcinoma pathogenesis.,2020,10.1038/s41416-020-0742-9,https://pubmed.ncbi.nlm.nih.gov/32020063/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,39394128,"Nucleotide sequence variants, gene expression and serum profile of immune and antioxidant markers associated with bacterial diarrhea susceptibility in Barki lambs.",2024,10.1186/s12917-024-04288-1,https://pubmed.ncbi.nlm.nih.gov/39394128/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FEZF1,ENSG00000128610,Unsafe,19318583,Human ZNF312b promotes the progression of gastric cancer by transcriptional activation of the K-ras gene.,2009,10.1158/0008-5472.can-08-2240,https://pubmed.ncbi.nlm.nih.gov/19318583/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FHAD1,ENSG00000142621,Unsafe,42010243,A high-resolution spatial map of cilia-associated proteins in the human fallopian tube.,2026,10.1038/s41467-026-71692-6,https://pubmed.ncbi.nlm.nih.gov/42010243/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FHAD1,ENSG00000142621,Unsafe,38563001,Forkhead-associated phosphopeptide binding domain 1 (FHAD1) deficiency impaired murine sperm motility.,2024,10.7717/peerj.17142,https://pubmed.ncbi.nlm.nih.gov/38563001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FHAD1,ENSG00000142621,Unsafe,41352571,Uterine artery transcriptomic signatures of e-cigarette aerosol exposure in pregnancy.,2026,10.1016/j.reprotox.2025.109133,https://pubmed.ncbi.nlm.nih.gov/41352571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FHAD1,ENSG00000142621,Unsafe,41007912,Uncovering Genetic Diversity and Adaptive Candidate Genes in the Mugalzhar Horse Breed Using Whole-Genome Sequencing Data.,2025,10.3390/ani15182667,https://pubmed.ncbi.nlm.nih.gov/41007912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FHAD1,ENSG00000142621,Unsafe,40421160,Combining long-read DNA and RNA sequencing to enhance molecular understanding of structural variations leading to copy gains.,2025,10.1016/j.csbj.2025.04.031,https://pubmed.ncbi.nlm.nih.gov/40421160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FHAD1,ENSG00000142621,Unsafe,36533556,Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants.,2022,10.1242/dmm.049568,https://pubmed.ncbi.nlm.nih.gov/36533556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FHAD1,ENSG00000142621,Unsafe,31127295,A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.,2019,10.1093/hmg/ddz070,https://pubmed.ncbi.nlm.nih.gov/31127295/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FHAD1,ENSG00000142621,Unsafe,27358489,Epigenome-Wide Tumor DNA Methylation Profiling Identifies Novel Prognostic Biomarkers of Metastatic-Lethal Progression in Men Diagnosed with Clinically Localized Prostate Cancer.,2017,10.1158/1078-0432.ccr-16-0549,https://pubmed.ncbi.nlm.nih.gov/27358489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FHAD1,ENSG00000142621,Unsafe,27716579,"The transcription factor, Nuclear factor, erythroid 2 (Nfe2), is a regulator of the oxidative stress response during Danio rerio development.",2016,10.1016/j.aquatox.2016.09.019,https://pubmed.ncbi.nlm.nih.gov/27716579/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FHAD1,ENSG00000142621,Unsafe,31429579,Cell Type-Specific Expression of Testis Elevated Genes Based on Transcriptomics and Antibody-Based Proteomics.,2019,10.1021/acs.jproteome.9b00351,https://pubmed.ncbi.nlm.nih.gov/31429579/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,42594276,A regulatory adaptor for RAD51's AAA+ unfoldase promotes homologous recombination-mediated DNA repair and genome stability.,2026,10.1073/pnas.2531632123,https://pubmed.ncbi.nlm.nih.gov/42594276/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,39319820,Exploring the Effect of Fidgetin-Like 1 on Colorectal Cancer Through Tissue Chip and In Vitro Experiments,2024,10.4274/balkanmedj.galenos.2024.2024-7-9,https://pubmed.ncbi.nlm.nih.gov/39319820/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,39147779,FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading.,2024,10.1038/s41467-024-51458-8,https://pubmed.ncbi.nlm.nih.gov/39147779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,39636933,Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin.,2025,10.1126/science.adr7920,https://pubmed.ncbi.nlm.nih.gov/39636933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,42905517,An engineered probiotic for diagnosis and mucosal healing in inflammatory bowel disease.,2026,10.1016/j.celrep.2026.118171,https://pubmed.ncbi.nlm.nih.gov/42905517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,42291750,Pharmacologic inhibition of RBBP4/p300-mediated homologous recombination activity enhances glioblastoma sensitivity to temozolomide.,2026,10.1093/noajnl/vdag141,https://pubmed.ncbi.nlm.nih.gov/42291750/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,37929733,FIGNL1 Promotes Hepatocellular Carcinoma Formation via Remodeling ECM-receptor Interaction Pathway Mediated by HMMR.,2024,10.2174/0115665232274223231017052707,https://pubmed.ncbi.nlm.nih.gov/37929733/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,37891173,FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.,2023,10.1038/s41467-023-42576-w,https://pubmed.ncbi.nlm.nih.gov/37891173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,42754673,ZEP1 orchestrates template choice and crossover pathways to ensure meiotic genome integrity in rice.,2026,10.1038/s44318-026-00910-0,https://pubmed.ncbi.nlm.nih.gov/42754673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,41091262,Identification of an E2Fs-based gene signature for predicting prognosis and therapeutic response in colorectal cancer.,2025,10.1007/s12672-025-02615-y,https://pubmed.ncbi.nlm.nih.gov/41091262/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,38597669,Human AAA+ ATPase FIGNL1 suppresses RAD51-mediated ultra-fine bridge formation.,2024,10.1093/nar/gkae263,https://pubmed.ncbi.nlm.nih.gov/38597669/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,38133958,Reconstitution of the antagonistic effect between C1orf112/FIRRM-FIGNL1 and BRCA2 on RAD51 filament stabilization.,2024,10.1016/j.xpro.2023.102791,https://pubmed.ncbi.nlm.nih.gov/38133958/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,39481482,Evolution and functional divergence of the Fidgetin family.,2025,10.1016/j.bbamcr.2024.119870,https://pubmed.ncbi.nlm.nih.gov/39481482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,39901712,Detection of single nucleotide polymorphisms associated with litter size in goats using genotyping-by-sequencing and association analysis.,2025,10.5713/ab.24.0533,https://pubmed.ncbi.nlm.nih.gov/39901712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,37556550,FIRRM cooperates with FIGNL1 to promote RAD51 disassembly during DNA repair.,2023,10.1126/sciadv.adf4082,https://pubmed.ncbi.nlm.nih.gov/37556550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,37740949,"Loss of function of FIGNL1, a DNA damage response gene, causes human ovarian dysgenesis.",2023,10.1093/ejendo/lvad127,https://pubmed.ncbi.nlm.nih.gov/37740949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,35232348,FIGNL1 Expression and its Prognostic Significance in Pan-cancer Analysis.,2022,10.2174/1386207325666220301110517,https://pubmed.ncbi.nlm.nih.gov/35232348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,37439366,The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart.,2023,10.1093/nar/gkad596,https://pubmed.ncbi.nlm.nih.gov/37439366/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,38286805,FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress.,2024,10.1038/s41467-024-45139-9,https://pubmed.ncbi.nlm.nih.gov/38286805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,35791674,FIGNL1 is a potential biomarker of cisplatin resistance in non-small cell lung cancer.,2022,10.1177/03936155221110249,https://pubmed.ncbi.nlm.nih.gov/35791674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,38612384,3-Methyl-4-nitrophenol Exposure Deteriorates Oocyte Maturation by Inducing Spindle Instability and Mitochondrial Dysfunction.,2024,10.3390/ijms25073572,https://pubmed.ncbi.nlm.nih.gov/38612384/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIGNL1,ENSG00000132436,Unsafe,34306022,Analysis of DNA Methylation Profiles in Mandibular Condyle of Chicks With Crossed Beaks Using Whole-Genome Bisulfite Sequencing.,2021,10.3389/fgene.2021.680115,https://pubmed.ncbi.nlm.nih.gov/34306022/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,42130655,Hypereosinophilic endocarditis presenting with intracardiac mass and severe mitral regurgitation: a case report of FIP1L1-PDGFRA positive myeloid neoplasm.,2026,10.1093/ehjcr/ytag296,https://pubmed.ncbi.nlm.nih.gov/42130655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,42135668,Myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions (FIP1L1::PDGFRA) complicated by Loeffler's endocarditis leading to stroke.,2026,10.1186/s12883-026-04890-w,https://pubmed.ncbi.nlm.nih.gov/42135668/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,41743957,Acute hemiplegia as initial presentation in FIP1L1-PDGFRA-rearranged myeloid neoplasm with eosinophilia: a case report.,2026,10.3389/fonc.2026.1628690,https://pubmed.ncbi.nlm.nih.gov/41743957/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,41668313,Recurrent Orogenital Ulcers: A Rare Case of Myeloid Neoplasm Associated with FIP1L1-PDGFRA Rearrangement with Rapid Response to Imatinib.,2026,10.4103/idoj.idoj_730_25,https://pubmed.ncbi.nlm.nih.gov/41668313/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,41532370,Ulcers and Eosinophils: A Rare Presentation of PDGFRA-Rearranged Myeloid Neoplasm Responding to Imatinib.,2026,10.1177/23247096251414051,https://pubmed.ncbi.nlm.nih.gov/41532370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,41655321,Myeloid neoplasm with eosinophilia associated with FIP1L1-PDGFRA presenting as femoral avascular necrosis: a rare case report.,2026,10.1016/j.htct.2026.106258,https://pubmed.ncbi.nlm.nih.gov/41655321/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,41426279,A rare case of variant acute promyelocytic leukemia with &lt;i&gt;FIP1L1-RARA&lt;/i&gt; fusion gene: case report and literature review.,2026,10.1016/j.lrr.2025.100553,https://pubmed.ncbi.nlm.nih.gov/41426279/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,41379052,Loeffler Syndrome in FIP1L1-PDGFRA-Positive Myeloid Neoplasm.,2026,10.1016/j.jaccas.2025.106296,https://pubmed.ncbi.nlm.nih.gov/41379052/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,41814313,Novel LUC7L::NUTM1 fusion in PDGFRA-rearranged myeloproliferative neoplasm with eosinophilia: a case report.,2026,10.1186/s12957-026-04298-3,https://pubmed.ncbi.nlm.nih.gov/41814313/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,39996417,FIP1L1::PDGFRA Fusion in a Pediatric Patient Presenting With B-Cell Lymphoblastic Leukemia.,2025,10.1002/gcc.70037,https://pubmed.ncbi.nlm.nih.gov/39996417/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,40454332,FIP1L1-PDGFRA Positive Chronic Eosinophilic Leukemia Presenting With Vestibular Neuritis.,2025,10.1002/ccr3.70554,https://pubmed.ncbi.nlm.nih.gov/40454332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,38887335,When Blood Cell Counts Matter: Hypereosinophilic Syndrome as a Rare Cause of Ischemic Strokes.,2024,10.7759/cureus.60557,https://pubmed.ncbi.nlm.nih.gov/38887335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,41935182,Comparison of gene fusion detection algorithms reveals frequently overlooked driver fusions in hematologic malignancies.,2026,10.1038/s41698-026-01397-y,https://pubmed.ncbi.nlm.nih.gov/41935182/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,40144421,Chronic Eosinophilic Leukemia Positive for FIP1L1-PDGFRa.,2025,10.7759/cureus.79548,https://pubmed.ncbi.nlm.nih.gov/40144421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,37238279,FIP1L1-PDGFRα-Positive Loeffler Endocarditis-A Distinct Cause of Heart Failure in a Young Male: The Role of Multimodal Diagnostic Tools.,2023,10.3390/diagnostics13101795,https://pubmed.ncbi.nlm.nih.gov/37238279/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,42301176,Loeffler Endocarditis: Multimodality Imaging of a Common Cardiac Phenotype in Distinct Hypereosinophilic Syndromes.,2026,10.1016/j.jaccas.2026.108674,https://pubmed.ncbi.nlm.nih.gov/42301176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,41587275,"First-in-Class Dual PDGFR/Carbonic Anhydrase IX/XII Inhibitors: 6,7-Dimethoxyquinoline-Sulfonamides as Promising Antileukemic Agents.",2026,10.1021/acs.jmedchem.5c03037,https://pubmed.ncbi.nlm.nih.gov/41587275/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,40384954,Loeffler endocarditis revealing chronic eosinophilic leukaemia with FIP1L1-PDGFRA rearrangement: a case report.,2025,10.1093/ehjcr/ytaf218,https://pubmed.ncbi.nlm.nih.gov/40384954/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,42513483,Organ Involvement and Constitutional Symptoms in Idiopathic Hypereosinophilic Syndrome: A 72-Patient Single-Centre Cohort.,2026,10.3390/jcm15145569,https://pubmed.ncbi.nlm.nih.gov/42513483/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,42074016,A Whole-Exome Sequencing-Based Exploration of Chronic Kidney Disease of Unknown Etiology (CKDu) in an Endemic Population in Sri Lanka.,2026,10.3390/ijms27083369,https://pubmed.ncbi.nlm.nih.gov/42074016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,42822811,Sustained low disease activity during long-term mepolizumab treatment in FIP1L1::PDGFRA-negative hypereosinophilic syndrome: a multicenter real-world study.,2026,10.1016/j.jaip.2026.09.021,https://pubmed.ncbi.nlm.nih.gov/42822811/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,41917160,"Benralizumab versus placebo for hypereosinophilic syndrome: a randomized, placebo-controlled phase 3 trial.",2026,10.1038/s41591-026-04315-8,https://pubmed.ncbi.nlm.nih.gov/41917160/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,42669182,Hypereosinophilic syndrome and suspected myeloid neoplasia in relapsed Hodgkin lymphoma during immune checkpoint inhibitor therapy: a rare case.,2026,10.1080/10428194.2026.2725345,https://pubmed.ncbi.nlm.nih.gov/42669182/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,37725576,Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma.,2023,10.1158/1078-0432.ccr-22-2562,https://pubmed.ncbi.nlm.nih.gov/37725576/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,40141849,Therapeutic Challenges and Emerging Strategies for &lt;i&gt;T674I&lt;/i&gt; and &lt;i&gt;PTPN11&lt;/i&gt; Mutations in a &lt;i&gt;FIP1L1-PDGFRA&lt;/i&gt;-Positive Myeloproliferative Neoplasm: A Case Report.,2025,10.3390/life15030505,https://pubmed.ncbi.nlm.nih.gov/40141849/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,40396537,Hypereosinophilia: clinical and therapeutic approach in 2025.,2025,10.1097/aci.0000000000001078,https://pubmed.ncbi.nlm.nih.gov/40396537/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,39389908,Phase II trial of imatinib mesylate in patients with PDGFRA/B-negative hypereosinophilic syndrome.,2024,10.1111/bjh.19828,https://pubmed.ncbi.nlm.nih.gov/39389908/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,39468717,Imatinib is effective in some PDGFRA/B-negative hypereosinophilic syndromes: A step closer to unveiling underlying mechanisms.,2024,10.1111/bjh.19853,https://pubmed.ncbi.nlm.nih.gov/39468717/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,37102594,"Novel FIP1L1::KIT fusion in a myeloid neoplasm with eosinophilia, T-lymphoblastic transformation, and dasatinib response.",2023,10.3324/haematol.2022.282636,https://pubmed.ncbi.nlm.nih.gov/37102594/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,41254115,Long read nanopore DNA sequencing with adaptive sampling to identify tyrosine kinase fusion genes.,2026,10.1038/s41375-025-02801-5,https://pubmed.ncbi.nlm.nih.gov/41254115/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,41131416,Novel BMP2K::PDGFRA fusion in an unusual myeloid/lymphoid neoplasm with eosinophilia.,2025,10.1007/s12308-025-00661-7,https://pubmed.ncbi.nlm.nih.gov/41131416/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,42106910,Hypereosinophilia of persistent/unknown cause: a bone marrow-based study integrating WHO-HAEM5 criteria and myeloid next-generation sequencing.,2026,10.1093/ajcp/aqag031,https://pubmed.ncbi.nlm.nih.gov/42106910/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,32269633,Imatinib therapy in acute myeloid leukemia with DEK-NUP214 and FIP1L1-PDGFRA rearrangement: A case report.,2020,10.3892/ol.2020.11455,https://pubmed.ncbi.nlm.nih.gov/32269633/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,31737382,An Intriguing Case of Eosinophilia with FIP1L1/PDGFRA Rearrangement Who Presented as Thrombotic Thrombocytopenic Purpura.,2019,10.1155/2019/2820954,https://pubmed.ncbi.nlm.nih.gov/31737382/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIP1L1,ENSG00000145216,Unsafe,37285821,False-Negative Testing for FIP1L1::PDGFRA by Fluorescence in situ Hybridization Is a Frequent Cause of Diagnostic Delay.,2023,10.1159/000528046,https://pubmed.ncbi.nlm.nih.gov/37285821/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,42594276,A regulatory adaptor for RAD51's AAA+ unfoldase promotes homologous recombination-mediated DNA repair and genome stability.,2026,10.1073/pnas.2531632123,https://pubmed.ncbi.nlm.nih.gov/42594276/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,42444944,C1ORF112 drives lung adenocarcinoma progression through e2f8-mediated transcriptional activation.,2026,10.21037/jtd-2026-1-0085,https://pubmed.ncbi.nlm.nih.gov/42444944/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,41878691,C1orf112 promotes breast cancer growth by modulating the cell cycle.,2026,10.3389/fbioe.2026.1717768,https://pubmed.ncbi.nlm.nih.gov/41878691/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,42007975,Novel driver gene FIRRM regulates the cell cycle for promoting tumor growth in hepatocellular carcinoma.,2026,10.1007/s00535-026-02380-x,https://pubmed.ncbi.nlm.nih.gov/42007975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,38133958,Reconstitution of the antagonistic effect between C1orf112/FIRRM-FIGNL1 and BRCA2 on RAD51 filament stabilization.,2024,10.1016/j.xpro.2023.102791,https://pubmed.ncbi.nlm.nih.gov/38133958/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,41239389,Molecular mechanisms by which C1orf112 promotes endometrial cancer progression and the development and validation of a clinical scoring model.,2025,10.1186/s13148-025-02003-x,https://pubmed.ncbi.nlm.nih.gov/41239389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,37256941,FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks.,2023,10.1126/sciadv.adf4409,https://pubmed.ncbi.nlm.nih.gov/37256941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,39147779,FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading.,2024,10.1038/s41467-024-51458-8,https://pubmed.ncbi.nlm.nih.gov/39147779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,39797737,Extensive homologous recombination safeguards oocyte genome integrity in mammals.,2025,10.1093/nar/gkae1304,https://pubmed.ncbi.nlm.nih.gov/39797737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,33625522,"Evolution, structure and emerging roles of C1ORF112 in DNA replication, DNA damage responses, and cancer.",2021,10.1007/s00018-021-03789-8,https://pubmed.ncbi.nlm.nih.gov/33625522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,34880897,High Expression of C1ORF112 Predicts a Poor Outcome: A Potential Target for the Treatment of Low-Grade Gliomas.,2021,10.3389/fgene.2021.710944,https://pubmed.ncbi.nlm.nih.gov/34880897/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,37556550,FIRRM cooperates with FIGNL1 to promote RAD51 disassembly during DNA repair.,2023,10.1126/sciadv.adf4082,https://pubmed.ncbi.nlm.nih.gov/37556550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,38769167,Deprivation of methionine inhibits osteosarcoma growth and metastasis via C1orf112-mediated regulation of mitochondrial functions.,2024,10.1038/s41419-024-06727-1,https://pubmed.ncbi.nlm.nih.gov/38769167/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,34490347,Pan-Cancer Analysis Identified C1ORF112 as a Potential Biomarker for Multiple Tumor Types.,2021,10.3389/fmolb.2021.693651,https://pubmed.ncbi.nlm.nih.gov/34490347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,39464736,Machine learning-based gene expression biomarkers to distinguish Zika and Dengue virus infections: implications for diagnosis.,2024,10.1007/s13337-024-00885-8,https://pubmed.ncbi.nlm.nih.gov/39464736/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,38286805,FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress.,2024,10.1038/s41467-024-45139-9,https://pubmed.ncbi.nlm.nih.gov/38286805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,34260926,Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation.,2021,10.1016/j.celrep.2021.109343,https://pubmed.ncbi.nlm.nih.gov/34260926/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,38453655,Bioinformatics identification of characteristic genes of cervical cancer via an artificial neural network.,2024,10.21037/cco-23-139,https://pubmed.ncbi.nlm.nih.gov/38453655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,33134315,Prognostic Prediction Using a Stemness Index-Related Signature in a Cohort of Gastric Cancer.,2020,10.3389/fmolb.2020.570702,https://pubmed.ncbi.nlm.nih.gov/33134315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,35117216,Comprehensive analysis of transcriptome data stemness indices identifies key genes for controlling cancer stem cell characteristics in gastric cancer.,2020,10.21037/tcr-20-704,https://pubmed.ncbi.nlm.nih.gov/35117216/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FIRRM,ENSG00000000460,Unsafe,33859719,Comprehensive Analysis of the Control of Cancer Stem Cell Characteristics in Endometrial Cancer by Network Analysis.,2021,10.1155/2021/6653295,https://pubmed.ncbi.nlm.nih.gov/33859719/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FLACC1,ENSG00000155749,Unsafe,33156557,FLACC1 is testis-specific but dispensable for fertility in mice.,2020,10.1002/mrd.23435,https://pubmed.ncbi.nlm.nih.gov/33156557/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FLACC1,ENSG00000155749,Unsafe,38724937,Genetic markers of cardiac autonomic neuropathy in the Kazakh population.,2024,10.1186/s12872-024-03912-0,https://pubmed.ncbi.nlm.nih.gov/38724937/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FLACC1,ENSG00000155749,Unsafe,29230837,Alterations in DNA methylation patterns and gene expression in spermatozoa of subfertile males.,2018,10.1111/and.12934,https://pubmed.ncbi.nlm.nih.gov/29230837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FLACC1,ENSG00000155749,Unsafe,25855136,New basal cell carcinoma susceptibility loci.,2015,10.1038/ncomms7825,https://pubmed.ncbi.nlm.nih.gov/25855136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FLACC1,ENSG00000155749,Unsafe,21402173,Expression of a sperm flagellum component encoded by the Als2cr12 gene.,2011,10.1016/j.gep.2011.03.003,https://pubmed.ncbi.nlm.nih.gov/21402173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FLACC1,ENSG00000155749,Unsafe,28801529,Silencing of Repetitive DNA Is Controlled by a Member of an Unusual Caenorhabditis elegans Gene Family.,2017,10.1534/genetics.117.300134,https://pubmed.ncbi.nlm.nih.gov/28801529/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FLACC1,ENSG00000155749,Unsafe,30753320,Association of genetic variants in CHEK2 with oesophageal squamous cell carcinoma in the South African Black population.,2019,10.1093/carcin/bgz026,https://pubmed.ncbi.nlm.nih.gov/30753320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FLACC1,ENSG00000155749,Unsafe,26795348,Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus.,2016,10.1158/0008-5472.can-15-1629,https://pubmed.ncbi.nlm.nih.gov/26795348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FLACC1,ENSG00000155749,Unsafe,29394417,Association Analysis Identifies New Risk Loci for Coal Workers' Pneumoconiosis in Han Chinese Men.,2018,10.1093/toxsci/kfy017,https://pubmed.ncbi.nlm.nih.gov/29394417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FLACC1,ENSG00000155749,Unsafe,27197191,"Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.",2016,10.1158/0008-5472.can-15-2980,https://pubmed.ncbi.nlm.nih.gov/27197191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FLACC1,ENSG00000155749,Unsafe,28542283,Shared susceptibility loci at 2q33 region for lung and esophageal cancers in high-incidence areas of esophageal cancer in northern China.,2017,10.1371/journal.pone.0177504,https://pubmed.ncbi.nlm.nih.gov/28542283/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FLACC1,ENSG00000155749,Unsafe,25168388,Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk.,2015,10.1093/hmg/ddu431,https://pubmed.ncbi.nlm.nih.gov/25168388/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FLACC1,ENSG00000155749,Unsafe,22323360,Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies.,2012,10.1093/hmg/dds029,https://pubmed.ncbi.nlm.nih.gov/22323360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMC1,ENSG00000164898,Unsafe,42295981,RPL27 Promotes Gastric Cancer Progression by Enhancing Oxidative Phosphorylation Via FMC1.,2026,10.1002/cbin.70178,https://pubmed.ncbi.nlm.nih.gov/42295981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMC1,ENSG00000164898,Unsafe,37864947,Fusogenic liposomes encapsulating mitochondria as a promising delivery system for osteoarthritis therapy.,2023,10.1016/j.biomaterials.2023.122350,https://pubmed.ncbi.nlm.nih.gov/37864947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMC1,ENSG00000164898,Unsafe,28719601,"CLIC, a tool for expanding biological pathways based on co-expression across thousands of datasets.",2017,10.1371/journal.pcbi.1005653,https://pubmed.ncbi.nlm.nih.gov/28719601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMC1,ENSG00000164898,Unsafe,25686363,Eukaryotic LYR Proteins Interact with Mitochondrial Protein Complexes.,2015,10.3390/biology4010133,https://pubmed.ncbi.nlm.nih.gov/25686363/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMC1,ENSG00000164898,Unsafe,22320183,Pericellular pH homeostasis is a primary function of the Warburg effect: inversion of metabolic systems to control lactate steady state in tumor cells.,2012,10.1111/j.1349-7006.2012.02206.x,https://pubmed.ncbi.nlm.nih.gov/22320183/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMC1,ENSG00000164898,Unsafe,15975925,Increasing mitochondrial substrate-level phosphorylation can rescue respiratory growth of an ATP synthase-deficient yeast.,2005,10.1074/jbc.m501831200,https://pubmed.ncbi.nlm.nih.gov/15975925/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMC1,ENSG00000164898,Unsafe,11096112,Identification of a nuclear gene (FMC1) required for the assembly/stability of yeast mitochondrial F(1)-ATPase in heat stress conditions.,2001,10.1074/jbc.m009557200,https://pubmed.ncbi.nlm.nih.gov/11096112/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMC1,ENSG00000164898,Unsafe,6240431,Monoclonal antibody-defined B cell subsets in aging humans and Down's syndrome.,1984,10.1159/000212661,https://pubmed.ncbi.nlm.nih.gov/6240431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMC1,ENSG00000164898,Unsafe,7950919,Peripheral blood lymphocyte surface antigen expression and prognosis in myeloma: Australian Leukaemia Study Group Study.,1994,10.3109/10428199409049682,https://pubmed.ncbi.nlm.nih.gov/7950919/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMC1,ENSG00000164898,Unsafe,2785969,Alterations in function and subpopulations of peripheral blood mononuclear leukocytes in children with portal hypertension. Leukocyte subtypes and function in portal hypertension.,1989,10.1159/000234823,https://pubmed.ncbi.nlm.nih.gov/2785969/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMC1,ENSG00000164898,Unsafe,6970772,Human lymphocyte markers defined by antibodies derived from somatic cell hybrids. IV. A monoclonal antibody reacting specifically with a subpopulation of human B lymphocytes.,1981,10.4049/jimmunol.126.4.1373,https://pubmed.ncbi.nlm.nih.gov/6970772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMC1,ENSG00000164898,Unsafe,23468261,Pharmacokinetic study of hydroxypropylmethylcellulose microparticles loaded with cimetidine.,2013,,https://pubmed.ncbi.nlm.nih.gov/23468261/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMC1,ENSG00000164898,Unsafe,6602365,The nature of hairy cells - a study with a panel of monoclonal antibodies.,1983,10.1111/j.1600-0609.1983.tb01479.x,https://pubmed.ncbi.nlm.nih.gov/6602365/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMC1,ENSG00000164898,Unsafe,3690893,Peripheral blood leucocyte subpopulations in patients splenectomized for trauma.,1987,,https://pubmed.ncbi.nlm.nih.gov/3690893/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,42706891,Integrated Genome-Wide Association Studies and Selection Signature Analysis Reveal the Genetic Architecture of the Wattle Trait in Goats.,2026,10.1002/age.70198,https://pubmed.ncbi.nlm.nih.gov/42706891/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,42393685,Structural-functional network decoupling in early stage amyotrophic lateral sclerosis reveals cell-type specific transcriptional signatures.,2026,10.1186/s12916-026-04932-7,https://pubmed.ncbi.nlm.nih.gov/42393685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,40316024,Nuclear protein FNBP4: A novel inhibitor of non-diaphanous formin FMN1-mediated actin cytoskeleton dynamics.,2025,10.1016/j.jbc.2025.108550,https://pubmed.ncbi.nlm.nih.gov/40316024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,39822733,A proteomic atlas of glypican-3 interacting partners: Identification of alpha-fetoprotein and other extracellular proteins as potential immunotherapy targets in liver cancer.,2024,10.1002/pgr2.70004,https://pubmed.ncbi.nlm.nih.gov/39822733/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,37095197,DHX9/DNA-tandem repeat-dependent downregulation of ciRNA-Fmn1 in the dorsal horn is required for neuropathic pain.,2023,10.1038/s41401-023-01082-x,https://pubmed.ncbi.nlm.nih.gov/37095197/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,42123621,Insights into Copy Number Variation Architecture in Black Bengal Goat Genome.,2026,10.3390/ijms27094045,https://pubmed.ncbi.nlm.nih.gov/42123621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,38188541,Probing the ligand binding specificity of FNBP4 WW domains and interaction with FH1 domain of FMN1.,2024,10.1016/j.crstbi.2023.100119,https://pubmed.ncbi.nlm.nih.gov/38188541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,40143670,Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations.,2025,10.1080/15592294.2025.2477850,https://pubmed.ncbi.nlm.nih.gov/40143670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,36498797,Screening and Identification of Key Biomarkers in Metastatic Uveal Melanoma: Evidence from a Bioinformatic Analysis.,2022,10.3390/jcm11237224,https://pubmed.ncbi.nlm.nih.gov/36498797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,37249599,A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk.,2023,10.1158/0008-5472.can-22-3713,https://pubmed.ncbi.nlm.nih.gov/37249599/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,40346907,Single-Cell Profiling of Mononuclear Cells Identifies Transcriptomics Signatures Differentiating Prostate Cancer From Benign Prostatic Hyperplasia.,2025,10.1002/gcc.70051,https://pubmed.ncbi.nlm.nih.gov/40346907/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,34559979,Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion.,2021,10.1016/j.devcel.2021.09.007,https://pubmed.ncbi.nlm.nih.gov/34559979/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,37407848,Immune micro-environment analysis and establishment of response prediction model for PD-1 blockade immunotherapy in glioblastoma based on transcriptome deconvolution.,2023,10.1007/s00432-023-05026-0,https://pubmed.ncbi.nlm.nih.gov/37407848/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,36093837,Distinct roles of the Chlamydia trachomatis effectors TarP and TmeA in the regulation of formin and Arp2/3 during entry.,2022,10.1242/jcs.260185,https://pubmed.ncbi.nlm.nih.gov/36093837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,37800836,Gastric cancer metastasis-related NT5DC2 indicates unfavorable prognosis of patients.,2023,10.1097/md.0000000000035030,https://pubmed.ncbi.nlm.nih.gov/37800836/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,34045313,Uncovering Modifier Genes of X-Linked Alport Syndrome Using a Novel Multiparent Mouse Model.,2021,10.1681/asn.2020060777,https://pubmed.ncbi.nlm.nih.gov/34045313/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,36014574,MOBT Alleviates Pulmonary Fibrosis through an lncITPF-hnRNP-l-Complex-Mediated Signaling Pathway.,2022,10.3390/molecules27165336,https://pubmed.ncbi.nlm.nih.gov/36014574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,36766725,Macrophages Promote Ovarian Cancer-Mesothelial Cell Adhesion by Upregulation of ITGA2 and VEGFC in Mesothelial Cells.,2023,10.3390/cells12030384,https://pubmed.ncbi.nlm.nih.gov/36766725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,35993291,Unique genetic signature and selection footprints in Dutch population of German Longhaired Pointer dogs.,2022,10.1111/age.13253,https://pubmed.ncbi.nlm.nih.gov/35993291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,31937228,Placental effects on the maternal brain revealed by disrupted placental gene expression in mouse hybrids.,2020,10.1098/rspb.2019.2563,https://pubmed.ncbi.nlm.nih.gov/31937228/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,36051697,COVID-19 in pediatrics: Genetic susceptibility.,2022,10.3389/fgene.2022.928466,https://pubmed.ncbi.nlm.nih.gov/36051697/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,32054832,FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism.,2020,10.1038/s41467-020-14525-4,https://pubmed.ncbi.nlm.nih.gov/32054832/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,35559993,A fertilin-derived peptide improves in vitro maturation and ploidy of human oocytes.,2022,10.1016/j.xfss.2021.10.004,https://pubmed.ncbi.nlm.nih.gov/35559993/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,24760772,Formin 1 and filamin B physically interact to coordinate chondrocyte proliferation and differentiation in the growth plate.,2014,10.1093/hmg/ddu186,https://pubmed.ncbi.nlm.nih.gov/24760772/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,29945573,Gene promoter and exon DNA methylation changes in colon cancer development - mRNA expression and tumor mutation alterations.,2018,10.1186/s12885-018-4609-x,https://pubmed.ncbi.nlm.nih.gov/29945573/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,26353782,DKK1 is a potential novel mediator of cisplatin-refractoriness in non-small cell lung cancer cell lines.,2015,10.1186/s12885-015-1635-9,https://pubmed.ncbi.nlm.nih.gov/26353782/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,25984239,Gene expression profiling reveals potential prognostic biomarkers associated with the progression of heart failure.,2015,10.1186/s13073-015-0149-z,https://pubmed.ncbi.nlm.nih.gov/25984239/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,19096130,Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients.,2008,10.1155/2008/426764,https://pubmed.ncbi.nlm.nih.gov/19096130/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FMN1,ENSG00000248905,Unsafe,20871662,"Identification of Diabetic Retinopathy Genes through a Genome-Wide Association Study among Mexican-Americans from Starr County, Texas.",2010,10.1155/2010/861291,https://pubmed.ncbi.nlm.nih.gov/20871662/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,42801553,LAPTM5 Downregulation-Driven VAMP8 Phosphorylation Impairs Autophagosome-Lysosome Fusion and Aggravates Septic Acute Lung Injury.,2026,10.1002/advs.78024,https://pubmed.ncbi.nlm.nih.gov/42801553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,41832353,Increased susceptibility to 4-HNE-induced toxicity and impaired development in a model of ALDH4A1-deficient pediatric epilepsy carrying the S352L variant.,2026,10.1038/s42003-026-09845-y,https://pubmed.ncbi.nlm.nih.gov/41832353/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,41905288,Genome-wide identification and expression profiling of Fox gene family reveals the potential functions of sex determination in Crassostrea gigas.,2026,10.1016/j.cbd.2026.101819,https://pubmed.ncbi.nlm.nih.gov/41905288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,38300670,"Chemo- and optogenetic activation of hypothalamic Foxb1-expressing neurons and their terminal endings in the rostral-dorsolateral PAG leads to tachypnea, bradycardia, and immobility.",2024,10.7554/elife.86737,https://pubmed.ncbi.nlm.nih.gov/38300670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,40468989,Integrated genomics and metabolomics to identify cause-specific biomarkers for chronic kidney disease in a Korean population.,2026,10.23876/j.krcp.24.135,https://pubmed.ncbi.nlm.nih.gov/40468989/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,40568194,Identifying key genes associated with recurrence in non-small cell lung cancer through TCGA and single-cell analysis.,2025,10.3389/fmed.2025.1549969,https://pubmed.ncbi.nlm.nih.gov/40568194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,39075111,Epigenetic aging studies of pair bonding in prairie voles.,2024,10.1038/s41598-024-67641-2,https://pubmed.ncbi.nlm.nih.gov/39075111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,39622796,"Comparative transcriptomic, epigenomic and immunological analyses identify drivers of disparity in high-grade serous ovarian cancer.",2024,10.1038/s41525-024-00448-2,https://pubmed.ncbi.nlm.nih.gov/39622796/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,39585426,Forkhead box P1 transcriptionally activates IGF-1 to lighten ox-LDL-induced endothelial cellular senescence by inactivating NLRP3 inflammasome.,2024,10.1007/s10522-024-10151-5,https://pubmed.ncbi.nlm.nih.gov/39585426/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,39725721,High-resolution DNA methylation changes reveal biomarkers of heart failure with preserved ejection fraction versus reduced ejection fraction.,2025,10.1007/s00395-024-01093-7,https://pubmed.ncbi.nlm.nih.gov/39725721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,35196094,A circuit from dorsal hippocampal CA3 to parvafox nucleus mediates chronic social defeat stress-induced deficits in preference for social novelty.,2022,10.1126/sciadv.abe8828,https://pubmed.ncbi.nlm.nih.gov/35196094/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,32802975,Interleukin 12-containing influenza virus-like-particle vaccine elevate its protective activity against heterotypic influenza virus infection.,2020,10.1016/j.heliyon.2020.e04543,https://pubmed.ncbi.nlm.nih.gov/32802975/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,28725186,Foxb1 Regulates Negatively the Proliferation of Oligodendrocyte Progenitors.,2017,10.3389/fnana.2017.00053,https://pubmed.ncbi.nlm.nih.gov/28725186/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,30027487,"Overexpression of a virus-like particle influenza vaccine in Eri silkworm pupae, using Autographa californica nuclear polyhedrosis virus and host-range expansion.",2018,10.1007/s00705-018-3941-4,https://pubmed.ncbi.nlm.nih.gov/30027487/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,33555045,Combinatorial transcription factor activities on open chromatin induce embryonic heterogeneity in vertebrates.,2021,10.15252/embj.2020104913,https://pubmed.ncbi.nlm.nih.gov/33555045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,26764531,Birthdate of parvalbumin-neurons in the Parvafox-nucleus of the lateral hypothalamus.,2016,10.1016/j.brainres.2015.12.054,https://pubmed.ncbi.nlm.nih.gov/26764531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,28167900,Parvalbumin-Neurons of the Ventrolateral Hypothalamic Parvafox Nucleus Receive a Glycinergic Input: A Gene-Microarray Study.,2017,10.3389/fnmol.2017.00008,https://pubmed.ncbi.nlm.nih.gov/28167900/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,26578897,LIM homeobox protein 5 (Lhx5) is essential for mamillary body development.,2015,10.3389/fnana.2015.00136,https://pubmed.ncbi.nlm.nih.gov/26578897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,27292133,The Foxb1-expressing neurons of the ventrolateral hypothalamic parvafox nucleus project to defensive circuits.,2016,10.1002/cne.24057,https://pubmed.ncbi.nlm.nih.gov/27292133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,30315416,The orbitofrontal cortex projects to the parvafox nucleus of the ventrolateral hypothalamus and to its targets in the ventromedial periaqueductal grey matter.,2019,10.1007/s00429-018-1771-5,https://pubmed.ncbi.nlm.nih.gov/30315416/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXB1,ENSG00000171956,Unsafe,26635092,A genome-wide association study of asthma symptoms in Latin American children.,2015,10.1186/s12863-015-0296-7,https://pubmed.ncbi.nlm.nih.gov/26635092/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,42841500,METTL3-Associated FOXD1 Regulation Promotes Lung Squamous Cell Carcinoma Progression: A Multimodel Experimental Approach.,2026,10.3791/73588,https://pubmed.ncbi.nlm.nih.gov/42841500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,42639061,"Notch-1 induces M2 polarization of tumor-associated macrophages via the YAP/EZH2/FOXD1/CD47 signaling axis, thereby driving non-small cell lung cancer progression.",2026,10.3389/fmed.2026.1801942,https://pubmed.ncbi.nlm.nih.gov/42639061/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,42701051,FOXD1 upregulates DARS2-mediated glycolysis to drive cisplatin resistance in bladder cancer.,2026,10.1016/j.urolonc.2026.07.027,https://pubmed.ncbi.nlm.nih.gov/42701051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,42361916,USP13-mediated stabilization of FOXD1 activates aerobic glycolysis to drive osteogenic differentiation and mitigate osteoporosis.,2026,10.1016/j.bcp.2026.118190,https://pubmed.ncbi.nlm.nih.gov/42361916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,41358813,Defects in nephrogenesis result in an expansion of the Foxd1+ stromal progenitor population.,2026,10.1242/dev.204964,https://pubmed.ncbi.nlm.nih.gov/41358813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,41214670,"FOXD1, a hypoxia-related gene, accelerates prostate cancer cell growth by increasing glycolysis under hypoxia conditions.",2025,10.1186/s12896-025-01061-6,https://pubmed.ncbi.nlm.nih.gov/41214670/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,40401803,Tumor-associated macrophage-derived exosomes modulate the immunotherapeutic sensitivity of SHH-medulloblastoma by targeting m6A-modified FOXD1.,2025,10.1093/neuonc/noaf123,https://pubmed.ncbi.nlm.nih.gov/40401803/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,42636108,Nephron and interstitial progenitor fates are plastic at the onset of mammalian kidney development.,2026,10.1016/j.celrep.2026.117893,https://pubmed.ncbi.nlm.nih.gov/42636108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,41632505,The transcription factor Tcf21 is necessary for adoption of cell fates by &lt;i&gt;Foxd1&lt;/i&gt;&lt;sup&gt;+&lt;/sup&gt; stromal progenitors during kidney development.,2026,10.1152/ajprenal.00345.2025,https://pubmed.ncbi.nlm.nih.gov/41632505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,40999468,The FOXD1/NAT10 positive feedback loop drives nasopharyngeal carcinoma progression.,2025,10.1186/s41065-025-00555-9,https://pubmed.ncbi.nlm.nih.gov/40999468/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,41897393,Dose-Dependent and Non-Autonomous Signaling in CAKUT: A Lineage-Specific Framework from Conditional Knockout Studies.,2026,10.3390/biom16030458,https://pubmed.ncbi.nlm.nih.gov/41897393/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,40210238,Neural crest-associated gene FOXD1 induces an immunosuppressive microenvironment by regulating myeloid-derived suppressor cells in melanoma.,2025,10.1136/jitc-2024-010352,https://pubmed.ncbi.nlm.nih.gov/40210238/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,38827805,Prognostic and clinicopathological significance of FOXD1 in various cancers: a meta and bioinformation analysis.,2024,10.2144/fsoa-2023-0085,https://pubmed.ncbi.nlm.nih.gov/38827805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,41241216,Ureteric stromal progenitors give rise to kidney inner cortical pericytes via an arterial mural cell intermediate.,2026,10.1016/j.ydbio.2025.11.005,https://pubmed.ncbi.nlm.nih.gov/41241216/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,40183774,Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation.,2025,10.7554/elife.100854,https://pubmed.ncbi.nlm.nih.gov/40183774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,40241815,Acupotomy Ameliorates KOA Related Chondrocyte Premature Senescence Through YAP/FOXD1 Pathway.,2025,10.2147/jpr.s475829,https://pubmed.ncbi.nlm.nih.gov/40241815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,40083705,Targeting ALG3/FOXD1/BNIP3 Axis Prevents Mitophagy and Gemcitabine Resistance of Nasopharyngeal Carcinoma.,2025,10.7150/ijbs.101585,https://pubmed.ncbi.nlm.nih.gov/40083705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,41803943,Integrated cross-sectional study and functional validation indicate the association of lactobacillus crispatus-derived D-lactic acid with cervical gene expression and precancerous cervical lesions.,2026,10.1186/s12967-026-07982-w,https://pubmed.ncbi.nlm.nih.gov/41803943/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,39805916,Transcription factor FOXD1 and miRNA-204-5p play a major role in B4GALNT2 downregulation in colon cancer.,2025,10.1038/s41598-025-85450-z,https://pubmed.ncbi.nlm.nih.gov/39805916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,38424240,"Assessing the fate and contribution of Foxd1-expressing embryonic precursors and their progeny in palatal development, homeostasis and excisional repair.",2024,10.1038/s41598-024-55486-8,https://pubmed.ncbi.nlm.nih.gov/38424240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,41614944,The Senescence-SASP Landscape in Colon Adenocarcinoma: Prognostic and Therapeutic Implications.,2026,10.3390/cimb48010114,https://pubmed.ncbi.nlm.nih.gov/41614944/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,41089440,Lower early-stage rectal cancer surgical approaches: therapeutic options and cancer biomarker alterations.,2025,10.3389/fsurg.2025.1656343,https://pubmed.ncbi.nlm.nih.gov/41089440/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,38517478,Long non-coding RNAFOXD1-AS1 modulated CTCs epithelial-mesenchymal transition and immune escape in hepatocellular carcinoma in vitro by sponging miR-615-3p.,2024,10.1002/cnr2.2050,https://pubmed.ncbi.nlm.nih.gov/38517478/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,38027647,FOXD1 expression-based prognostic model for uveal melanoma.,2023,10.1016/j.heliyon.2023.e21333,https://pubmed.ncbi.nlm.nih.gov/38027647/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,39757274,Integrated singlecell and bulk RNA-seq analysis identifies a prognostic signature related to inflammation in colorectal cancer.,2025,10.1038/s41598-024-84998-6,https://pubmed.ncbi.nlm.nih.gov/39757274/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,35607308,"The Expression and Survival Significance of FOXD1 in Lung Squamous Cell Carcinoma: A Meta-Analysis, Immunohistochemistry Validation, and Bioinformatics Analysis.",2022,10.1155/2022/7798654,https://pubmed.ncbi.nlm.nih.gov/35607308/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,39368544,A modified model of PANoptosisto identify prognosis and immunotherapy response in bladder cancer.,2024,10.1016/j.biocel.2024.106672,https://pubmed.ncbi.nlm.nih.gov/39368544/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,37563111,miR-30e-5p-mediated FOXD1 promotes cell proliferation by blocking cellular senescence and apoptosis through p21/CDK2/Rb signaling in head and neck carcinoma.,2023,10.1038/s41420-023-01571-2,https://pubmed.ncbi.nlm.nih.gov/37563111/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,41510109,"The role of microRNAs in gastritis, intestinal metaplasia, and gastric cancer: a narrative review.",2025,10.21037/tcr-2025-1-2642,https://pubmed.ncbi.nlm.nih.gov/41510109/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,37203394,FOXD1 promotes chemotherapy resistance by enhancing cell stemness in colorectal cancer through β‑catenin nuclear localization.,2023,10.3892/or.2023.8571,https://pubmed.ncbi.nlm.nih.gov/37203394/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,38512513,Integrative analysis with machine learning identifies diagnostic and prognostic signatures in neuroblastoma based on differentially DNA methylated enhancers between INSS stage 4 and 4S neuroblastoma.,2024,10.1007/s00432-024-05650-4,https://pubmed.ncbi.nlm.nih.gov/38512513/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,37234983,FOXD1 is associated with poor outcome and maintains tumor-promoting enhancer-gene programs in basal-like breast cancer.,2023,10.3389/fonc.2023.1156111,https://pubmed.ncbi.nlm.nih.gov/37234983/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXD1,ENSG00000251493,Unsafe,39494294,Forkhead box D subfamily genes in colorectal cancer: potential biomarkers and therapeutic targets.,2024,10.7717/peerj.18406,https://pubmed.ncbi.nlm.nih.gov/39494294/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,41862116,Foxg1 regulates the development of microvillous cells in the olfactory epithelium.,2026,10.1016/j.ydbio.2026.03.009,https://pubmed.ncbi.nlm.nih.gov/41862116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,42879492,FOXG1 spatiotemporally orchestrates subtype fate specification and patch/matrix identity of striatal spiny projection neurons.,2026,10.1073/pnas.2603031123,https://pubmed.ncbi.nlm.nih.gov/42879492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,42481467,Analysis of 14q12 microdeletions reveals novel regulatory loci for the neurodevelopmental disorder-related gene FOXG1.,2026,10.1038/s41467-026-75694-2,https://pubmed.ncbi.nlm.nih.gov/42481467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,42236689,Non-coding structural variants disrupt FOXG1 transcriptional regulation in early neurodevelopment.,2026,10.1038/s41467-026-73770-1,https://pubmed.ncbi.nlm.nih.gov/42236689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,42586389,PRMT6 drives hearing loss by promoting asymmetric arginine dimethylation-mediated FOXG1 degradation and suppressing mitophagy.,2026,10.1016/j.exger.2026.113278,https://pubmed.ncbi.nlm.nih.gov/42586389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,42912189,FOXG1 Enhances Paclitaxel Resistance in Prostate Cancer via NANOG-Mediated Cellular Stemness.,2026,10.1177/15579883261500924,https://pubmed.ncbi.nlm.nih.gov/42912189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,42063249,"Early Isoflurane Exposure Is Associated With Delayed Adolescent Neurobehavioral Deficits, Accompanied by Dysregulation of FOXG1 and EB3.",2026,10.1002/dneu.70033,https://pubmed.ncbi.nlm.nih.gov/42063249/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,42799825,"Disruption of FOXG1 Impairs the Development of Striatal dSPNs, Thereby Contributing to ASD-Like Phenotypes.",2026,10.1007/s12264-026-01727-x,https://pubmed.ncbi.nlm.nih.gov/42799825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,42182986,The H3K9me2-FOXG1-microRNA axis reduces cochlear hair cells damage by modulating autophagy in age-related hearing loss.,2026,10.3389/fnmol.2026.1834102,https://pubmed.ncbi.nlm.nih.gov/42182986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,39301848,foxg1a is required for hair cell development and regeneration in the zebrafish lateral line.,2024,10.1242/bio.060580,https://pubmed.ncbi.nlm.nih.gov/39301848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,41390674,miR-101/METTL3 axis induces autophagy by interrupting FOXG1/EIF3J-AS1 binding in gliomas.,2025,10.1038/s41419-025-08285-6,https://pubmed.ncbi.nlm.nih.gov/41390674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,38378191,Evolutionarily conserved roles of foxg1a in the developing subpallium of zebrafish embryos.,2024,10.1111/dgd.12917,https://pubmed.ncbi.nlm.nih.gov/38378191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,42062284,Functional impact of genetic background on variable expressivity in neurodevelopmental disorders.,2026,10.1038/s41467-026-72598-z,https://pubmed.ncbi.nlm.nih.gov/42062284/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,41997343,Integrating molecular studies and clinical disease models to provide mechanistic insight into neurodevelopment: guidance from FOXG1 syndrome.,2026,10.1016/j.ydbio.2026.04.005,https://pubmed.ncbi.nlm.nih.gov/41997343/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,41895646,Ciprofloxacin exposure impairs neurogenesis and E/I balance in human cortical organoids.,2026,10.1016/j.neuropharm.2026.110931,https://pubmed.ncbi.nlm.nih.gov/41895646/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,40548942,The lincRNA Pantr1 is a FOXG1 target gene conferring site-specific chromatin binding of FOXG1.,2025,10.1093/nar/gkaf539,https://pubmed.ncbi.nlm.nih.gov/40548942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,42803093,FOXG1 syndrome: genetic background revealed by trio WES in case of a critically ill neonate.,2026,10.18071/isz.79.0351,https://pubmed.ncbi.nlm.nih.gov/42803093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,40524015,Functional defects in FOXG1 variants predict the severity of brain anomalies in FOXG1 syndrome.,2025,10.1038/s41380-025-03077-y,https://pubmed.ncbi.nlm.nih.gov/40524015/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,41627775,FOXG1 Hierarchically Shapes Synaptic Functions in Striatal iSPNs and Contributes to ASD Etiology.,2026,10.1007/s12264-025-01573-3,https://pubmed.ncbi.nlm.nih.gov/41627775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,41994447,"KDM5B recruits FOXG1 to suppress the IFN response, leading to malignant progression and immune evasion in cervical cancer.",2026,10.3389/fmed.2026.1749536,https://pubmed.ncbi.nlm.nih.gov/41994447/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,41136907,"Longitudinal characterization of clinical, developmental, and behavioral phenotypes in 101 children and adults with FOXG1 syndrome.",2025,10.1186/s11689-025-09653-1,https://pubmed.ncbi.nlm.nih.gov/41136907/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,40561474,Foxg1 gene mutation impairs auditory cortex response and reduces sound tolerance.,2025,10.1093/cercor/bhaf166,https://pubmed.ncbi.nlm.nih.gov/40561474/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,38843374,FOXG1 Syndrome,1993,,https://pubmed.ncbi.nlm.nih.gov/38843374/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,40882535,Natural history of epilepsy in FOXG1 Syndrome.,2025,10.1016/j.eplepsyres.2025.107644,https://pubmed.ncbi.nlm.nih.gov/40882535/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,40461535,Forebrain neural progenitors effectively integrate into host brain circuits and improve neural function after ischemic stroke.,2025,10.1038/s41467-025-60187-5,https://pubmed.ncbi.nlm.nih.gov/40461535/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,42352918,Rapid and Robust Generation of Human Cortical Interneurons from Induced Neural Stem Cells.,2026,10.3390/ijms27125194,https://pubmed.ncbi.nlm.nih.gov/42352918/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,41893700,Preliminary Transcriptomic Insights into the Combined Pathogenesis of Avian Leukosis Virus and &lt;i&gt;Salmonella pullorum&lt;/i&gt; Co-Infection.,2026,10.3390/vetsci13030283,https://pubmed.ncbi.nlm.nih.gov/41893700/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,40903954,Foxg1 and companions: Not only transcription factors.,2026,10.4103/nrr.nrr-d-25-00439,https://pubmed.ncbi.nlm.nih.gov/40903954/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,41244709,RNA-based therapies for neurodevelopmental disorders: innovative tools for molecular correction.,2025,10.3389/fmolb.2025.1681647,https://pubmed.ncbi.nlm.nih.gov/41244709/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,39624968,FOXG1 interaction with SATB2 promotes autophagy to alleviate neuroinflammation and mechanical abnormal pain in rats with lumbar disc herniation.,2024,10.1080/07853890.2024.2399967,https://pubmed.ncbi.nlm.nih.gov/39624968/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,39183266,"Foxg1 regulates translation of neocortical neuronal genes, including the main NMDA receptor subunit gene, Grin1.",2024,10.1186/s12915-024-01979-x,https://pubmed.ncbi.nlm.nih.gov/39183266/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,38932521,FoxG1/BNIP3 axis promotes mitophagy and blunts cisplatin resistance in osteosarcoma.,2024,10.1111/cas.16242,https://pubmed.ncbi.nlm.nih.gov/38932521/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,38582517,Menin Deficiency Induces Autism-Like Behaviors by Regulating Foxg1 Transcription and Participates in Foxg1-Related Encephalopathy.,2024,10.1002/advs.202307953,https://pubmed.ncbi.nlm.nih.gov/38582517/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,39135718,Drug repurposing in Rett and Rett-like syndromes: a promising yet underrated opportunity?,2024,10.3389/fmed.2024.1425038,https://pubmed.ncbi.nlm.nih.gov/39135718/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,40560632,"Atoh1 is required for the formation of lateral line electroreceptors and hair cells, whereas FoxG1 represses an electrosensory fate.",2025,10.7554/elife.96285,https://pubmed.ncbi.nlm.nih.gov/40560632/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,41999986,Self-organized anteroposterior regionalization of early midbrain and hindbrain/spinal cords using micropatterned human pluripotent stem cells.,2026,10.1016/j.slast.2026.100419,https://pubmed.ncbi.nlm.nih.gov/41999986/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXG1,ENSG00000176165,Unsafe,7959731,"Human brain factor 1, a new member of the fork head gene family.",1994,10.1006/geno.1994.1313,https://pubmed.ncbi.nlm.nih.gov/7959731/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,42610666,Age-Opposed Rewiring of Upstream Translation-Initiation Pattern Across Different Types of Human Cancers.,2026,10.1177/15578100261479259,https://pubmed.ncbi.nlm.nih.gov/42610666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,41803108,Epilepsy-associated FOXJ3 variants link a transcriptional program of the PTEN-mTOR pathway to neuronal specification and cortical lamination.,2026,10.1038/s41467-026-69241-2,https://pubmed.ncbi.nlm.nih.gov/41803108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,42226735,OutFOXed: FOXJ3 Variants Disrupt PTEN-mTOR Signaling in Focal Epilepsy.,2026,10.1177/15357597261455996,https://pubmed.ncbi.nlm.nih.gov/42226735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,42291103,SOX2 promotes the progression of hepatocellular carcinoma by targeting FOXJ3 and activating the PI3K/AKT pathway to regulate autophagy and mitophagy.,2026,10.25259/cytojournal_164_2025,https://pubmed.ncbi.nlm.nih.gov/42291103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,41268239,Targeting the FoxJ3/FoxO6 axis suppresses hepatocellular carcinoma growth by inducing cell cycle arrest and apoptosis.,2025,10.62347/pvig8848,https://pubmed.ncbi.nlm.nih.gov/41268239/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,41268592,FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis.,2026,10.3892/mmr.2025.13760,https://pubmed.ncbi.nlm.nih.gov/41268592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,40837006,Transcriptome Combined with Mendelian Randomization to Identify and Validate Biomarkers Associated with Parthanatos in Sepsis.,2025,10.2147/jir.s532066,https://pubmed.ncbi.nlm.nih.gov/40837006/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,40522413,Foxj3 represses TGF-β signals-responsive transcriptions in Xenopus early development.,2025,10.1007/s13258-025-01654-7,https://pubmed.ncbi.nlm.nih.gov/40522413/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,42368450,Aging-associated transcriptional programming of mitochondrial respiration in alveolar type II epithelial cells.,2026,10.3389/fcell.2026.1740661,https://pubmed.ncbi.nlm.nih.gov/42368450/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,41202951,Identification of a novel RET::FOXJ3 fusion in lung adenocarcinoma associated with lack of response to pralsetinib.,2026,10.1016/j.canlet.2025.218100,https://pubmed.ncbi.nlm.nih.gov/41202951/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,39907030,"Super-Enhancer Target Gene CBP/p300-Interacting Transactivator With Glu/Asp-Rich C-Terminal Domain, 2 Cooperates With Transcription Factor Forkhead Box J3 to Inhibit Pulmonary Vascular Remodeling.",2025,10.1111/cpr.13817,https://pubmed.ncbi.nlm.nih.gov/39907030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,42190389,"Mechanisms of testicular toxicity uncovered by multi-omics: 9,10-epoxy stearic acid as a foodborne contaminant in mice.",2026,10.1016/j.ecoenv.2026.120299,https://pubmed.ncbi.nlm.nih.gov/42190389/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,39811681,"FOXJ3, a novel tumor suppressor in neuroblastoma.",2025,10.1016/j.omton.2024.200914,https://pubmed.ncbi.nlm.nih.gov/39811681/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,40700217,Transcriptional Signatures of Aerobic Exercise-Induced Muscle Adaptations in Humans.,2025,10.3390/jfmk10030281,https://pubmed.ncbi.nlm.nih.gov/40700217/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,37939221,Foxj3 Regulates Thermogenesis of Brown and Beige Fat Via Induction of PGC-1α.,2024,10.2337/db23-0454,https://pubmed.ncbi.nlm.nih.gov/37939221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,41729176,Genome-Wide Association Study of Leukocyte Traits Reveals Candidate Genes Associated With Immunity in Holstein Cattle From Southern China.,2026,10.1002/vms3.70858,https://pubmed.ncbi.nlm.nih.gov/41729176/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,39596356,Exosomal mRNA Signatures as Predictive Biomarkers for Risk and Age of Onset in Alzheimer's Disease.,2024,10.3390/ijms252212293,https://pubmed.ncbi.nlm.nih.gov/39596356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,37351974,FOXJ3 Regulates Cell Proliferation and Motility Through Modulating Snail Expression in Breast Cancer Cells.,2023,10.21873/anticanres.16470,https://pubmed.ncbi.nlm.nih.gov/37351974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,40001606,Omics Investigations of Prostate Cancer Cells Exposed to Simulated Microgravity Conditions.,2025,10.3390/biom15020303,https://pubmed.ncbi.nlm.nih.gov/40001606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXJ3,ENSG00000198815,Unsafe,34724864,Circular RNA circSLC8A1 inhibits the proliferation and invasion of non-small cell lung cancer cells through targeting the miR-106b-5p /FOXJ3 axis.,2021,10.1080/15384101.2021.1995968,https://pubmed.ncbi.nlm.nih.gov/34724864/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,40487439,"&lt;i&gt;p21&lt;/i&gt;, &lt;i&gt;ccng1&lt;/i&gt;, &lt;i&gt;foxo3b&lt;/i&gt;, and &lt;i&gt;fbxw7&lt;/i&gt; contribute to &lt;i&gt;p53&lt;/i&gt;-dependent cell cycle arrest.",2025,10.1016/j.isci.2025.112558,https://pubmed.ncbi.nlm.nih.gov/40487439/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,34880903,Gestational Age Dependence of the Maternal Circulating Long Non-Coding RNA Transcriptome During Normal Pregnancy Highlights Antisense and Pseudogene Transcripts.,2021,10.3389/fgene.2021.760849,https://pubmed.ncbi.nlm.nih.gov/34880903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,37976965,Identification of lncRNA-based regulatory mechanisms of Takifugu rubripes growth traits in fast and slow-growing family lines.,2024,10.1016/j.cbd.2023.101164,https://pubmed.ncbi.nlm.nih.gov/37976965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,32502192,Zebrafish rbm8a and magoh mutants reveal EJC developmental functions and new 3'UTR intron-containing NMD targets.,2020,10.1371/journal.pgen.1008830,https://pubmed.ncbi.nlm.nih.gov/32502192/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,29925039,A splice junction-targeted CRISPR approach (spJCRISPR) reveals human FOXO3B to be a protein-coding gene.,2018,10.1016/j.gene.2018.06.048,https://pubmed.ncbi.nlm.nih.gov/29925039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,36061477,Effects of a Topical Anti-aging Formulation on Skin Aging Biomarkers.,2022,,https://pubmed.ncbi.nlm.nih.gov/36061477/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,27777301,Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL).,2016,10.1074/jbc.m116.745471,https://pubmed.ncbi.nlm.nih.gov/27777301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,27815423,Zebrafish foxo3b Negatively Regulates Antiviral Response through Suppressing the Transactivity of irf3 and irf7.,2016,10.4049/jimmunol.1601187,https://pubmed.ncbi.nlm.nih.gov/27815423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,26960338,Foxo3b but not Foxo3a activates cyp19a1a in Epinephelus coioides.,2016,10.1530/jme-15-0251,https://pubmed.ncbi.nlm.nih.gov/26960338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,24445282,Zebrafish eaf1 suppresses foxo3b expression to modulate transcriptional activity of gata1 and spi1 in primitive hematopoiesis.,2014,10.1016/j.ydbio.2014.01.005,https://pubmed.ncbi.nlm.nih.gov/24445282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,30905685,FOXO genes in channel catfish and their response after bacterial infection.,2019,10.1016/j.dci.2019.03.010,https://pubmed.ncbi.nlm.nih.gov/30905685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,21915332,Zebrafish foxo3b negatively regulates canonical Wnt signaling to affect early embryogenesis.,2011,10.1371/journal.pone.0024469,https://pubmed.ncbi.nlm.nih.gov/21915332/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,25843800,Knockdown of transcription factor forkhead box O3 (FOXO3) suppresses erythroid differentiation in human cells and zebrafish.,2015,10.1016/j.bbrc.2015.03.128,https://pubmed.ncbi.nlm.nih.gov/25843800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,32544425,Modulation of redox and insulin signaling underlie the anti-hyperglycemic and antioxidant effects of diphenyl diselenide in zebrafish.,2020,10.1016/j.freeradbiomed.2020.06.002,https://pubmed.ncbi.nlm.nih.gov/32544425/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,32758839,"Emerging contaminant 1,3,6,8-tetrabromocarbazole induces oxidative damage and apoptosis during the embryonic development of zebrafish (Danio rerio).",2020,10.1016/j.scitotenv.2020.140753,https://pubmed.ncbi.nlm.nih.gov/32758839/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,26390814,Characterization of F-spondin in Japanese flounder (Paralichthys olivaceus) and its role in the nervous system development of teleosts.,2016,10.1016/j.gene.2015.09.037,https://pubmed.ncbi.nlm.nih.gov/26390814/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,22459618,FOXO3 gene variants and human aging: coding variants may not be key players.,2012,10.1093/gerona/gls067,https://pubmed.ncbi.nlm.nih.gov/22459618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,28204905,Transcriptome assembly and identification of genes and SNPs associated with growth traits in largemouth bass (Micropterus salmoides).,2017,10.1007/s10709-017-9956-z,https://pubmed.ncbi.nlm.nih.gov/28204905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXO3B,ENSG00000240445,Unsafe,22588664,Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B.,2013,10.1038/ejhg.2012.83,https://pubmed.ncbi.nlm.nih.gov/22588664/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42529738,&lt;i&gt;FOXP3&lt;/i&gt; deep intronic variant underlying IPEX.,2026,10.70962/jhi.20260021,https://pubmed.ncbi.nlm.nih.gov/42529738/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42450051,&lt;i&gt;FOXP3&lt;/i&gt; Mutations and Instability as Determinants of Regulatory T-Cell Plasticity in Endocrine Autoimmunity.,2026,10.3390/ijms27135778,https://pubmed.ncbi.nlm.nih.gov/42450051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,41909206,Refractory infantile IPEX with Treg-restricted FOXP3null expression caused by a novel variant in &lt;i&gt;FOXP3&lt;/i&gt;.,2026,10.70962/jhi.20250249,https://pubmed.ncbi.nlm.nih.gov/41909206/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42693276,Targeting the FOXP3-T-bet interaction to restore Treg stability in IFN-γ-driven autoimmunity.,2026,10.1038/s41423-026-01468-x,https://pubmed.ncbi.nlm.nih.gov/42693276/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42676327,Case Report: Effective IL-4/IL-13 axis suppression and resolution of severe atopic dermatitis by dupilumab monotherapy in a patient with IPEX syndrome.,2026,10.3389/fimmu.2026.1923415,https://pubmed.ncbi.nlm.nih.gov/42676327/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42509742,First Comprehensive Analysis of Full-Length and Δ2 Foxp3 Isoforms Distribution in PBMCs from Healthy Volunteers.,2026,10.3390/biom16070948,https://pubmed.ncbi.nlm.nih.gov/42509742/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,41653277,Pediatric IPEX-Associated Dermatitis Responds To Dupilumab: Evidence from Skin Transcriptomics and Immune Profiling.,2026,10.1007/s10875-025-01979-8,https://pubmed.ncbi.nlm.nih.gov/41653277/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,41117878,Beyond the Classical Triad: Atypical Presentations and Regulatory T Cell Phenotyping in a Cohort of IPEX Patients.,2025,10.1007/s10875-025-01934-7,https://pubmed.ncbi.nlm.nih.gov/41117878/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42092823,"X-Linked immune dysregulation, polyendocrinopathy, and enteropathy (IPEX) syndrome with concurrent membranous and IgA nephropathy: a case report.",2026,10.1186/s12882-026-05015-8,https://pubmed.ncbi.nlm.nih.gov/42092823/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42169995,Except the unexpected: A TIPIC syndrome in a child with IPEX.,2026,10.70962/jhi.20250246,https://pubmed.ncbi.nlm.nih.gov/42169995/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42626447,Tumor cell-specific exon 3-deleted FOXP3 isoform promotes growth and metastasis via STAT3 in non-small cell lung cancer.,2026,10.1093/lifemedi/lnag024,https://pubmed.ncbi.nlm.nih.gov/42626447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42694788,FOXP3 Stability-Adaptation Paradox: Reshaping Treg-Based Therapies for Intestinal Diseases.,2026,10.7150/ijbs.137066,https://pubmed.ncbi.nlm.nih.gov/42694788/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42883805,Regulatory T Cells Across Oral Diseases: A Narrative Review on a Functional Perspective.,2026,10.3390/ijms27198555,https://pubmed.ncbi.nlm.nih.gov/42883805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42213824,SRSF3 determines T&lt;sub&gt;reg&lt;/sub&gt; cell fate in antitumor immunity and autoimmunity.,2026,10.1126/sciadv.aeh1671,https://pubmed.ncbi.nlm.nih.gov/42213824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42703812,Role of Epigenetic Modifications in The Aberrant Expression of The &lt;i&gt;FOXP3&lt;/i&gt; Gene in Endometriosis: A Case-Control Study.,2026,10.22074/ijfs.2025.2042585.1770,https://pubmed.ncbi.nlm.nih.gov/42703812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42709426,Targeting FOXP3 and Regulatory T Cells in Systemic Lupus Erythematosus: Emerging Therapeutic Strategies and Clinical Prospects.,2026,10.1002/jcb.70124,https://pubmed.ncbi.nlm.nih.gov/42709426/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,41728887,"Immune Dysregulation, Polyendocrinopathy and Enteropathy X-Linked Syndrome with Neonatal Onset: A Case Report.",2026,10.20344/amp.23795,https://pubmed.ncbi.nlm.nih.gov/41728887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,41832599,Preclinical efficacy and safety assessment of engineered regulatory T cells for treatment of IPEX and other autoimmune disorders.,2026,10.1016/j.ymthe.2026.03.017,https://pubmed.ncbi.nlm.nih.gov/41832599/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42890837,Association of phenotypic and functional characteristics of regulatory T cells from minor salivary glands with expression of the delta 7 FoxP3 splice variant in patients with Sjögren's disease.,2026,10.3389/fimmu.2026.1959200,https://pubmed.ncbi.nlm.nih.gov/42890837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,39136284,"A splice of life: the discovery, function, and clinical implications of FOXP3 isoforms in autoimmune disease.",2024,10.1093/intimm/dxae049,https://pubmed.ncbi.nlm.nih.gov/39136284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42638924,Biomarker-driven neoadjuvant immunotherapy in triple-negative breast cancer: emerging therapeutic targets FOXP3 and WT1.,2026,10.3389/fimmu.2026.1851289,https://pubmed.ncbi.nlm.nih.gov/42638924/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42603165,Regulatory T cells: From Foxp3 to tolerance-inducing therapies.,2026,10.1016/j.jid.2026.05.009,https://pubmed.ncbi.nlm.nih.gov/42603165/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42328446,"RMAD1, a Novel Cell-Penetrating Peptide Derived from ADARB2: Preclinical Insights into Antigen Uptake and T Cell Activation.",2026,10.7150/ijbs.132948,https://pubmed.ncbi.nlm.nih.gov/42328446/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42794439,Integrated Immune Escape in Cervical Cancer: HLA-I Dysfunction and Immune Checkpoint Signaling.,2026,10.3390/ijms27188009,https://pubmed.ncbi.nlm.nih.gov/42794439/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42043781,Phase I Trial of Ipatasertib plus Atezolizumab Enhances PI3K/AKT Pathway Immune Responses in Solid Tumors and Refractory Glioblastoma.,2026,10.1158/1078-0432.ccr-25-4364,https://pubmed.ncbi.nlm.nih.gov/42043781/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,41655742,Regulatory T cells from concept to clinic: The 2025 Nobel Prize and its implications for immune-mediated diseases and cancer.,2026,10.1016/j.bj.2026.100959,https://pubmed.ncbi.nlm.nih.gov/41655742/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42542574,Encapsulated cell therapy for local anti-CTLA-4 delivery in cancer immunotherapy.,2026,10.1016/j.isci.2026.116938,https://pubmed.ncbi.nlm.nih.gov/42542574/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,42514958,Targeting CDK4/6 in Combination with Phage-Based Anti-HER2 Vaccination Overcomes Immune Evasion and Enhances the Anticancer Response in Breast Cancer.,2026,10.3390/pharmaceutics18070881,https://pubmed.ncbi.nlm.nih.gov/42514958/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FOXP3,ENSG00000049768,Unsafe,41758930,Regulatory-like FOXP3+Helios+CD4+ T conventional cells correlate with T-cell activation after Orca-T immunotherapy.,2026,10.1182/blood.2025031545,https://pubmed.ncbi.nlm.nih.gov/41758930/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FRMPD1,ENSG00000070601,Unsafe,42878851,Alternative splicing dynamics in pig tissues under soybean oil supplementation.,2026,10.1007/s00335-026-10279-4,https://pubmed.ncbi.nlm.nih.gov/42878851/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FRMPD1,ENSG00000070601,Unsafe,40699790,FBXO10 Drives Hepatocellular Carcinoma Proliferation via K63-Linked Ubiquitination and Stabilization of FRMPD1.,2025,10.3390/cimb47060391,https://pubmed.ncbi.nlm.nih.gov/40699790/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FRMPD1,ENSG00000070601,Unsafe,40525903,Identification of protein-coding genes associated with metastatic prostate cancer.,2025,10.1530/erc-25-0070,https://pubmed.ncbi.nlm.nih.gov/40525903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FRMPD1,ENSG00000070601,Unsafe,36180221,Frmpd1 Facilitates Trafficking of G-Protein Transducin and Modulates Synaptic Function in Rod Photoreceptors of Mammalian Retina.,2022,10.1523/eneuro.0348-22.2022,https://pubmed.ncbi.nlm.nih.gov/36180221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FRMPD1,ENSG00000070601,Unsafe,31114375,FRMPD1 activates the Hippo pathway via interaction with WWC3 to suppress the proliferation and invasiveness of lung cancer cells.,2019,10.2147/cmar.s194512,https://pubmed.ncbi.nlm.nih.gov/31114375/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FRMPD1,ENSG00000070601,Unsafe,30445545,Targeted deletion of an NRL- and CRX-regulated alternative promoter specifically silences FERM and PDZ domain containing 1 (Frmpd1) in rod photoreceptors.,2019,10.1093/hmg/ddy388,https://pubmed.ncbi.nlm.nih.gov/30445545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FRMPD1,ENSG00000070601,Unsafe,18566450,The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins.,2008,10.1074/jbc.m803497200,https://pubmed.ncbi.nlm.nih.gov/18566450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FRMPD1,ENSG00000070601,Unsafe,25664792,Structural basis for the recognition of the scaffold protein Frmpd4/Preso1 by the TPR domain of the adaptor protein LGN.,2015,10.1107/s2053230x14028143,https://pubmed.ncbi.nlm.nih.gov/25664792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FRMPD1,ENSG00000070601,Unsafe,17404222,Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk.,2007,10.1073/pnas.0701687104,https://pubmed.ncbi.nlm.nih.gov/17404222/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FRMPD1,ENSG00000070601,Unsafe,25786224,Novel genetic locus implicated for HIV-1 acquisition with putative regulatory links to HIV replication and infectivity: a genome-wide association study.,2015,10.1371/journal.pone.0118149,https://pubmed.ncbi.nlm.nih.gov/25786224/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FRMPD1,ENSG00000070601,Unsafe,22074847,Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN).,2011,10.1073/pnas.1110951108,https://pubmed.ncbi.nlm.nih.gov/22074847/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,42593172,The characteristics and expression profile of follicle-stimulating hormone and luteinizing hormone during gonadal development in silver pomfret.,2026,10.1111/jfb.70576,https://pubmed.ncbi.nlm.nih.gov/42593172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,42609294,Expression and RNAi characterization of neuropeptides underlying developmental regulation in the Colorado potato beetle.,2026,10.3389/finsc.2026.1862257,https://pubmed.ncbi.nlm.nih.gov/42609294/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,41024941,Expression of Follicle-Stimulating Hormone Receptor in Von Hippel-Lindau Associated Tumors and Cysts: An Immunohistochemical Study.,2025,10.15586/jkc.v12i3.409,https://pubmed.ncbi.nlm.nih.gov/41024941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,42621710,[Mechanism of acupuncture regulating cAMP signaling pathway to improve ovarian dysfunction in sleep-deprived mice].,2026,10.13702/j.1000-0607.20251079,https://pubmed.ncbi.nlm.nih.gov/42621710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,39773308,Atlas of Fshr expression from novel reporter mice.,2025,10.7554/elife.93413,https://pubmed.ncbi.nlm.nih.gov/39773308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,41465365,Integrated Role of Arginine Vasotocin in the Control of Spermatogenesis in Zebrafish.,2025,10.3390/ijms262411938,https://pubmed.ncbi.nlm.nih.gov/41465365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,41916974,FSHR and LHR functional compensation reveals the mechanism and treatment of Ovarian Hyperstimulation Syndrome.,2026,10.1038/s41467-026-71338-7,https://pubmed.ncbi.nlm.nih.gov/41916974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,42800552,"Implications of neuropeptide Y in the regulation of testicular functions in wall lizard, Hemidactylus flaviviridis.",2026,10.1016/j.cbpa.2026.112079,https://pubmed.ncbi.nlm.nih.gov/42800552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,41825718,Molecular characterization and differential regulation of sex steroids on the gonadotropin ligand-receptor system in mandarin fish (Siniperca chuatsi).,2026,10.1016/j.jsbmb.2026.106990,https://pubmed.ncbi.nlm.nih.gov/41825718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,41339973,"N-acetylcysteine Improved Expression of FSHR, LHCGR, Catsper-1, Catsper-2, and SF-1 Genes in Testis of Rats with Varicocele.",2026,10.1007/s43032-025-02018-y,https://pubmed.ncbi.nlm.nih.gov/41339973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,42730635,In vivo evidence for Urotensin II as a regulator of reproduction in GIFT tilapia (Oreochromis niloticus).,2026,10.1093/biolre/ioag197,https://pubmed.ncbi.nlm.nih.gov/42730635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,39633277,Revisiting the follicle-stimulation hormone receptor expression and function in human myometrium and adipose tissue.,2024,10.1186/s10020-024-01015-2,https://pubmed.ncbi.nlm.nih.gov/39633277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,42552301,Single-cell atlas of reproductive endocrine organs reveals transcriptomic responses to type 1 diabetes mellitus in nonhuman primates.,2026,10.1038/s41421-026-00908-2,https://pubmed.ncbi.nlm.nih.gov/42552301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,41955481,Fosl2 Regulates FSH-Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling.,2026,10.1002/advs.75223,https://pubmed.ncbi.nlm.nih.gov/41955481/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,42442675,Follicle-stimulating hormone and cancer.,2026,10.1016/j.cellsig.2026.112738,https://pubmed.ncbi.nlm.nih.gov/42442675/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,42085637,Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target.,2026,10.1002/advs.75523,https://pubmed.ncbi.nlm.nih.gov/42085637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,42412303,From Gene Function to Precision Intervention: CRISPR/Cas9 and Stem Cell-Based Strategies as Emerging Disease-Modifying Approaches in PMOS.,2026,10.1007/s12015-026-11188-4,https://pubmed.ncbi.nlm.nih.gov/42412303/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,41876092,The role of the follicle-stimulating hormone receptor in supporting male reproduction: A narrative review.,2026,10.5653/cerm.2025.08571,https://pubmed.ncbi.nlm.nih.gov/41876092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,42325707,Spontaneous ovarian hyperstimulation syndrome with a previously undescribed gene mutation of the follicle-stimulating hormone receptor gene: a case report.,2026,10.1016/j.xfre.2026.03.006,https://pubmed.ncbi.nlm.nih.gov/42325707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,41844581,C/EBPβ dictates postmenopausal FSHβ transcription and blockade of AEP/C/EBPβ pathway alleviates osteoporosis.,2026,10.1038/s41413-026-00510-y,https://pubmed.ncbi.nlm.nih.gov/41844581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,39741875,Targeting the FSH/FSHR axis in ovarian cancer: advanced treatment using nanotechnology and immunotherapy.,2024,10.3389/fendo.2024.1489767,https://pubmed.ncbi.nlm.nih.gov/39741875/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,41795109,Identification of novel therapeutic targets for ovarian hypofunction through hormonal pathway regulation.,2026,10.1186/s12896-026-01110-8,https://pubmed.ncbi.nlm.nih.gov/41795109/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,41202450,FSHR-GnRH bispecific vaccine suppresses the fertility of female rats.,2026,10.1016/j.theriogenology.2025.117742,https://pubmed.ncbi.nlm.nih.gov/41202450/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,41145057,FSHβ/FSHR subunit vaccines attenuate high-fat diet-induced adipose deposition in female rats.,2026,10.1016/j.theriogenology.2025.117724,https://pubmed.ncbi.nlm.nih.gov/41145057/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,41813798,CD28 co-stimulatory domain enhances efficacy of CER T cell therapy compared to 4-1BB in an ovarian cancer mouse model.,2026,10.1038/s41598-026-43225-0,https://pubmed.ncbi.nlm.nih.gov/41813798/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,41377277,"Harnessing the anticancer potential of &lt;i&gt;Moringa oleifera&lt;/i&gt;: a safer, multi-targeted adjunct.",2025,10.1097/ms9.0000000000004227,https://pubmed.ncbi.nlm.nih.gov/41377277/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,40399468,Targeting FSHR is a highly promising strategy for improving cognitive impairment in postmenopausal women.,2025,10.1038/s41380-025-03048-3,https://pubmed.ncbi.nlm.nih.gov/40399468/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,42816913,Differential Gene Expression of Mesenchymal Stromal Cell and Granulosa Cell Markers in Equine Follicular Aspirates.,2026,10.1111/rda.70288,https://pubmed.ncbi.nlm.nih.gov/42816913/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,42721757,"Chronic labetalol exposure induced dose-dependent testicular toxicity via disruptingt HPG-axis, spermatogenesis and steroidogenic pathways: A biochemical, molecular and histopathological evidence.",2026,10.1016/j.tice.2026.103924,https://pubmed.ncbi.nlm.nih.gov/42721757/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,42641055,"Optimisation of Dietary Lipid in Genetically Selected Clarias magur in Term of Gonadal Growth, Reproductive Performance, and Expression of Reproduction-Related Genes.",2026,10.1111/jpn.70103,https://pubmed.ncbi.nlm.nih.gov/42641055/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,42119666,"FSH mediated endocrine disruption potential of Dibutyl phthalate in cultured ovine ovarian granulosa cells: Cytotoxicity, oxidative stress, steroidogenesis, cell senescence, and expression of related key developmental genes.",2026,10.1016/j.reprotox.2026.109262,https://pubmed.ncbi.nlm.nih.gov/42119666/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,41131503,Exploring genotype-phenotype correlation of FSHR polymorphisms in polycystic ovary syndrome.,2025,10.1186/s12902-025-01979-0,https://pubmed.ncbi.nlm.nih.gov/41131503/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,40490708,Targeted destruction of follicle stimulating hormone receptor-positive cancer cells in vitro and in vivo by a lytic peptide Phor21-FSHβ conjugate.,2025,10.1186/s10020-025-01292-5,https://pubmed.ncbi.nlm.nih.gov/40490708/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,40368516,Melatonin reverses bisphenol A-induced toxicity in granulosa cells: Restoration of FSHR and connexin 43 expression.,2025,10.1016/j.tjog.2025.02.003,https://pubmed.ncbi.nlm.nih.gov/40368516/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,42703834,Phenotype-Specific Association of &lt;i&gt;LHCGR&lt;/i&gt; rs13405728 Polymorphism with Anovulatory Infertility in Malay Women with Polycystic Ovary Syndrome: A Case-Control Study.,2026,10.22074/ijfs.2025.2065767.1908,https://pubmed.ncbi.nlm.nih.gov/42703834/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSHR,ENSG00000170820,Unsafe,36509287,A mAb against surface-expressed FSHR engineered to engage adaptive immunity for ovarian cancer immunotherapy.,2022,10.1172/jci.insight.162553,https://pubmed.ncbi.nlm.nih.gov/36509287/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,41097635,The FSIP Family: Roles in Health and Cancer.,2025,10.3390/cancers17193107,https://pubmed.ncbi.nlm.nih.gov/41097635/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,41794281,Interleukin-27 promotes oral squamous cell carcinoma pathogenesis via FSIP1-mediated activation of the PI3K-Akt signaling pathway.,2026,10.1016/j.bbagen.2026.130926,https://pubmed.ncbi.nlm.nih.gov/41794281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,38737444,Elevated mRNA level indicates FSIP1 promotes EMT and gastric cancer progression by regulating fibroblasts in tumor microenvironment.,2024,10.1515/med-2024-0964,https://pubmed.ncbi.nlm.nih.gov/38737444/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,39530064,FOXN3 Regulates Autophagic Activity to Suppress Drug Resistance in Melanoma Cells.,2024,10.2147/ccid.s462854,https://pubmed.ncbi.nlm.nih.gov/39530064/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,37460715,FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway.,2023,10.1007/s11427-023-2343-y,https://pubmed.ncbi.nlm.nih.gov/37460715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,33901807,Bi-allelic mutation in Fsip1 impairs acrosome vesicle formation and attenuates flagellogenesis in mice.,2021,10.1016/j.redox.2021.101969,https://pubmed.ncbi.nlm.nih.gov/33901807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,35692888,FSIP1 Is Associated with Poor Prognosis and Can Be Used to Construct a Prognostic Model in Gastric Cancer.,2022,10.1155/2022/2478551,https://pubmed.ncbi.nlm.nih.gov/35692888/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,32699582,Clinical significance of expression of fibrous sheath interacting protein 1 in colon cancer.,2020,10.4251/wjgo.v12.i6.677,https://pubmed.ncbi.nlm.nih.gov/32699582/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,30814489,Over-expression of FSIP1 promotes breast cancer progression and confers resistance to docetaxel via MRP1 stabilization.,2019,10.1038/s41419-018-1248-8,https://pubmed.ncbi.nlm.nih.gov/30814489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,30509973,FSIP1 regulates autophagy in breast cancer.,2018,10.1073/pnas.1809681115,https://pubmed.ncbi.nlm.nih.gov/30509973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,29670371,Knockdown of fibrous sheath interacting protein 1 expression reduces bladder urothelial carcinoma cell proliferation and induces apoptosis via inhibition of the PI3K/AKT pathway.,2018,10.2147/ott.s158275,https://pubmed.ncbi.nlm.nih.gov/29670371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,31713931,FSIP1 is correlated with estrogen receptor status and poor prognosis.,2020,10.1002/mc.23134,https://pubmed.ncbi.nlm.nih.gov/31713931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,28086239,Elevated fibrous sheath interacting protein 1 levels are associated with poor prognosis in non-small cell lung cancer patients.,2017,10.18632/oncotarget.14575,https://pubmed.ncbi.nlm.nih.gov/28086239/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,28860802,Fibrous sheath interacting protein 1 overexpression is associated with unfavorable prognosis in bladder cancer: a potential therapeutic target.,2017,10.2147/ott.s143491,https://pubmed.ncbi.nlm.nih.gov/28860802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,28674022,FSIP1 binds HER2 directly to regulate breast cancer growth and invasiveness.,2017,10.1073/pnas.1621486114,https://pubmed.ncbi.nlm.nih.gov/28674022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,32305967,RNA-seq analysis identified hormone-related genes associated with prognosis of triple negative breast cancer.,2020,10.7555/jbr.34.20190111,https://pubmed.ncbi.nlm.nih.gov/32305967/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,23905897,Elevated expression of cancer/testis antigen FSIP1 in ER-positive breast tumors.,2013,10.2217/bmm.13.58,https://pubmed.ncbi.nlm.nih.gov/23905897/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,25826084,Expression and clinicopathological significance of FSIP1 in breast cancer.,2015,10.18632/oncotarget.3381,https://pubmed.ncbi.nlm.nih.gov/25826084/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,32717308,Loss-of-function variants in FSIP1 identified by targeted sequencing are associated with one particular subtype of mucosal melanoma.,2020,10.1016/j.gene.2020.144964,https://pubmed.ncbi.nlm.nih.gov/32717308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,30915882,Novel DNA methylation sites associated with cigarette smoking among African Americans.,2019,10.1080/15592294.2019.1588683,https://pubmed.ncbi.nlm.nih.gov/30915882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP1,ENSG00000150667,Unsafe,22869527,Multiple cancer testis antigens function to support tumor cell mitotic fidelity.,2012,10.1128/mcb.00686-12,https://pubmed.ncbi.nlm.nih.gov/22869527/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,42169611,Novel biallelic FSIP2 variants cause male infertility with multiple morphological abnormalities of sperm flagella in humans.,2026,10.4103/aja202611,https://pubmed.ncbi.nlm.nih.gov/42169611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,42667560,Biallelic FSIP2 variants are associated with sperm defective chromatin condensation beyond MMAF and acrosomal abnormalities.,2026,10.1007/s10815-026-04017-7,https://pubmed.ncbi.nlm.nih.gov/42667560/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,41097635,The FSIP Family: Roles in Health and Cancer.,2025,10.3390/cancers17193107,https://pubmed.ncbi.nlm.nih.gov/41097635/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,41809782,Homozygous &lt;i&gt;Myo7A&lt;/i&gt; mutation associations teratozoospermia and intracytoplasmic sperm injection failure in humans and mice.,2026,10.21037/tau-2025-474,https://pubmed.ncbi.nlm.nih.gov/41809782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,40968718,Novel mutations in FSIP2 cause male infertility through multiple morphological abnormalities of the sperm flagella.,2026,10.4103/aja202542,https://pubmed.ncbi.nlm.nih.gov/40968718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,41566433,Sperm RNA landscape during sexual maturation in Duroc boars.,2026,10.1186/s12864-025-12490-0,https://pubmed.ncbi.nlm.nih.gov/41566433/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,39972276,Identification of key genes related to unilateral cryptorchidism in sheep by comprehensive transcriptomics and proteomics analyses.,2025,10.1186/s12864-024-11166-5,https://pubmed.ncbi.nlm.nih.gov/39972276/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,39753944,Novel variants of FSIP2 and SPEF2 cause varying degrees of spermatozoa damage in MMAF patients and favorable ART outcomes.,2025,10.1007/s10815-024-03378-1,https://pubmed.ncbi.nlm.nih.gov/39753944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,41725028,Whole Exome Sequencing of Feline Oral Squamous Cell Carcinoma Reveals Genomic Parallels With Human Head and Neck Squamous Cell Carcinoma.,2026,10.1111/vco.70054,https://pubmed.ncbi.nlm.nih.gov/41725028/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,41115892,Identifying potential genetic biomarkers for sperm dysfunction through whole-genome sequencing.,2025,10.1038/s41598-025-23897-w,https://pubmed.ncbi.nlm.nih.gov/41115892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,41209567,Mapping the Somatic Mutation Landscape of Familial NF2-Related Schwannomatosis using Whole-Exome Sequencing.,2025,10.7150/ijms.121550,https://pubmed.ncbi.nlm.nih.gov/41209567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,36632462,Novel FSIP2 Variants Induce Super-Length Mitochondrial Sheath and Asthenoteratozoospermia in Humans.,2023,10.7150/ijbs.76051,https://pubmed.ncbi.nlm.nih.gov/36632462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,39349455,CEP112 coordinates translational regulation of essential fertility genes during spermiogenesis through phase separation in humans and mice.,2024,10.1038/s41467-024-52705-8,https://pubmed.ncbi.nlm.nih.gov/39349455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,37979751,Comprehensive analyses of 435 goat transcriptomes provides insight into male reproduction.,2024,10.1016/j.ijbiomac.2023.127942,https://pubmed.ncbi.nlm.nih.gov/37979751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,40783785,METTL5 deficiency induces oligoasthenoteratozoospermia via impaired 18S rRNA m&lt;sup&gt;6&lt;/sup&gt;A methylation in humans and mice.,2025,10.1016/j.ymthe.2025.08.009,https://pubmed.ncbi.nlm.nih.gov/40783785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,39267058,Whole exome sequencing analysis of 167 men with primary infertility.,2024,10.1186/s12920-024-02005-3,https://pubmed.ncbi.nlm.nih.gov/39267058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,39842729,Genome-Wide and Rare Variant Association Studies of Amblyopia in the All of Us Research Program.,2025,10.1016/j.ophtha.2025.01.013,https://pubmed.ncbi.nlm.nih.gov/39842729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,40376536,Establishment and clinical significance of genetic factor screening method for patients with nonobstructive azoospermia based on whole exon sequencing technology.,2025,10.21037/tau-2024-676,https://pubmed.ncbi.nlm.nih.gov/40376536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,33162809,FSIP2 can serve as a predictive biomarker for Clear Cell Renal Cell Carcinoma prognosis.,2020,10.7150/ijms.48971,https://pubmed.ncbi.nlm.nih.gov/33162809/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,41578300,"Adjuvant tislelizumab, lenvatinib, and capecitabine for resected biliary tract cancer: a prospective phase II trial.",2026,10.1186/s12916-026-04650-0,https://pubmed.ncbi.nlm.nih.gov/41578300/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,34113648,Association Between FSIP2 Mutation and an Improved Efficacy of Immune Checkpoint Inhibitors in Patients With Skin Cutaneous Melanoma.,2021,10.3389/fmolb.2021.629330,https://pubmed.ncbi.nlm.nih.gov/34113648/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,34513706,Combination of 35-Gene Mutation Profile and Radiotherapy Dosimetry Predicts the Therapeutic Outcome of Definitive Chemoradiation in Patients With Esophageal Squamous Cell Carcinoma.,2021,10.3389/fonc.2021.729418,https://pubmed.ncbi.nlm.nih.gov/34513706/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,37932811,"Genomic signatures of selection, local adaptation and production type characterisation of East Adriatic sheep breeds.",2023,10.1186/s40104-023-00936-y,https://pubmed.ncbi.nlm.nih.gov/37932811/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,34095982,A novel genomic classification system of gastric cancer via integrating multidimensional genomic characteristics.,2021,10.1007/s10120-021-01201-9,https://pubmed.ncbi.nlm.nih.gov/34095982/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,35222516,Comprehensive Genomic and Epigenomic Analyses on Transcriptomic Regulation in Stomach Adenocarcinoma.,2021,10.3389/fgene.2021.778095,https://pubmed.ncbi.nlm.nih.gov/35222516/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,28027327,Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis.,2016,10.1371/journal.pmed.1002201,https://pubmed.ncbi.nlm.nih.gov/28027327/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
FSIP2,ENSG00000188738,Unsafe,30137358,Whole-exome sequencing identifies mutations in FSIP2 as a recurrent cause of multiple morphological abnormalities of the sperm flagella.,2018,10.1093/humrep/dey264,https://pubmed.ncbi.nlm.nih.gov/30137358/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,42551538,Exposure to environmentally relevant concentrations of zearalenone disrupts blood-testis barrier via inositol-requiring enzyme 1α-dependent GA binding protein transcription factor α mRNA decay.,2026,10.1016/j.cbi.2026.112276,https://pubmed.ncbi.nlm.nih.gov/42551538/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,42820930,The IKKε-GABPA axis regulates STING transcription to orchestrate antiviral immunity and inflammation.,2026,10.1084/jem.20252599,https://pubmed.ncbi.nlm.nih.gov/42820930/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,42527997,Investigating the Role of Oxidative Stress Parameters in the Spectrum of Preschool Anxiety Disorders.,2026,10.1111/eip.70242,https://pubmed.ncbi.nlm.nih.gov/42527997/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,42538229,GABPA recruits the Integrator endonuclease complex to promote transcription elongation.,2026,10.1016/j.scib.2026.07.060,https://pubmed.ncbi.nlm.nih.gov/42538229/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,42378254,Phosphorylated DEK sustains leukemia stem cells by enabling PBX3-driven transcriptional reprogramming.,2026,10.1182/blood.2025032710,https://pubmed.ncbi.nlm.nih.gov/42378254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,42638197,scRNA-Seq Links CD8 Effector T Cells to Periodontitis via Transcriptional Reprogramming and Enhanced PARs Signaling.,2026,10.1111/odi.70423,https://pubmed.ncbi.nlm.nih.gov/42638197/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,41422226,Suppressing the OTUD7A/KDM5B/GABPA axis enhances the sensitivity of cisplatin through inducing ferroptosis in KRAS-mutant LUAD.,2025,10.1038/s41419-025-08337-x,https://pubmed.ncbi.nlm.nih.gov/41422226/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,40813762,The ETS transcription factor GABPA inhibits bladder cancer aggressiveness by repressing extracellular matrix deposition and mechanotransduction signaling.,2025,10.1038/s41419-025-07935-z,https://pubmed.ncbi.nlm.nih.gov/40813762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,41545595,Single-cell atlas of the developing Down syndrome brain cortex.,2026,10.1038/s41591-026-04211-1,https://pubmed.ncbi.nlm.nih.gov/41545595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,40818967,"Multi-omics approach reveals CCND1, GABPA, HIF1A, and SOX6 as key regulators and prognostic markers in heart failure.",2025,10.1186/s41065-025-00536-y,https://pubmed.ncbi.nlm.nih.gov/40818967/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,39759007,miR-450b-5p promotes development of endometriosis by inhibiting the GABPA/HOXD10 axis.,2024,10.1016/j.isci.2024.111487,https://pubmed.ncbi.nlm.nih.gov/39759007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,41484630,Hypoxia-induced PRMT6 expression promotes temozolomide chemoresistance in glioblastoma via G3BP1.,2026,10.1186/s12967-025-07618-5,https://pubmed.ncbi.nlm.nih.gov/41484630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,41817108,DDX21 Links &lt;i&gt;BRAF&lt;sup&gt;V600E&lt;/sup&gt;&lt;/i&gt; and TERT to Promote Thyroid Cancer Progression.,2026,10.1177/10507256261417697,https://pubmed.ncbi.nlm.nih.gov/41817108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,39489850,GABPA inhibits tumorigenesis in clear cell renal cell carcinoma by regulating ferroptosis through ACSL4.,2024,10.1038/s41598-024-78441-z,https://pubmed.ncbi.nlm.nih.gov/39489850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,40332239,Transcriptional Regulators in the Cerebellum in Chronic Schizophrenia: Novel Possible Targets for Pharmacological Interventions.,2025,10.3390/ijms26083653,https://pubmed.ncbi.nlm.nih.gov/40332239/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,42346129,The Reconstitution of the Macrophage Niche Reveals Dynamic Transcriptional and Renal Macrophage-Epithelial Communication Networks.,2026,10.3390/cells15121102,https://pubmed.ncbi.nlm.nih.gov/42346129/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,38628657,"Crucial role of lncRNA NONHSAG037054.2 and GABPA, and their related functional networks, in ankylosing spondylitis.",2024,10.3892/etm.2024.12525,https://pubmed.ncbi.nlm.nih.gov/38628657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,39747581,The transcription factor GABPA is a master regulator of naive pluripotency.,2025,10.1038/s41556-024-01554-0,https://pubmed.ncbi.nlm.nih.gov/39747581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,40749747,HMGB1 activates caspase-1 and induces hepatic stellate cell activation via GABPA-ASC.,2025,10.1016/j.bbamcr.2025.120032,https://pubmed.ncbi.nlm.nih.gov/40749747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,39151728,A transcriptional regulatory mechanism of genes in the tricarboxylic acid cycle in the heart.,2024,10.1016/j.jbc.2024.107677,https://pubmed.ncbi.nlm.nih.gov/39151728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,41300749,Integrative Bioinformatics Analysis Reveals Key Regulatory Genes and Therapeutic Targets in Ulcerative Colitis Pathogenesis.,2025,10.3390/genes16111296,https://pubmed.ncbi.nlm.nih.gov/41300749/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,39141674,Induction of Thymus Atrophy and Disruption of Thymocyte Development by Fipronil through Dysregulation of IL-7-Associated Genes.,2024,10.1021/acs.chemrestox.4c00060,https://pubmed.ncbi.nlm.nih.gov/39141674/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,39461328,Inhibition of KDM4A restricts SQLE transcription and induces oxidative stress imbalance to suppress bladder cancer.,2024,10.1016/j.redox.2024.103407,https://pubmed.ncbi.nlm.nih.gov/39461328/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,34306255,GABPA Expression in Endometrial Carcinoma: A Prognostic Marker.,2021,10.1155/2021/5552614,https://pubmed.ncbi.nlm.nih.gov/34306255/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,41144480,Weighted gene co-expression network analysis identifies functional modules related to bovine respiratory disease.,2025,10.1371/journal.pone.0334688,https://pubmed.ncbi.nlm.nih.gov/41144480/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,35958019,Up-Regulation of RACGAP1 Promotes Progressions of Hepatocellular Carcinoma Regulated by GABPA via PI3K/AKT Pathway.,2022,10.1155/2022/3034150,https://pubmed.ncbi.nlm.nih.gov/35958019/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,38188177,Multi-omics reveals changed energy metabolism of liver and muscle by caffeine after mice swimming.,2024,10.7717/peerj.16677,https://pubmed.ncbi.nlm.nih.gov/38188177/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,34781940,Hub microRNAs and genes in the development of atrial fibrillation identified by weighted gene co-expression network analysis.,2021,10.1186/s12920-021-01124-5,https://pubmed.ncbi.nlm.nih.gov/34781940/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,37798647,IL-33 priming and antigenic stimulation synergistically promote the transcription of proinflammatory cytokine and chemokine genes in human skin mast cells.,2023,10.1186/s12864-023-09702-w,https://pubmed.ncbi.nlm.nih.gov/37798647/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,35693634,Expression Profile and Molecular Basis of Cyclin-Dependent Kinases Regulatory Subunit 2 in Endometrial Carcinoma Detected by Diversified Methods.,2022,10.3389/pore.2022.1610307,https://pubmed.ncbi.nlm.nih.gov/35693634/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,31280495,Leukocyte transcriptional signatures dependent on LPS dosage in human endotoxemia.,2019,10.1002/jlb.4a0219-050r,https://pubmed.ncbi.nlm.nih.gov/31280495/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,31482761,Breakdown of multiple sclerosis genetics to identify an integrated disease network and potential variant mechanisms.,2019,10.1152/physiolgenomics.00120.2018,https://pubmed.ncbi.nlm.nih.gov/31482761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,23284628,The ETS transcription factors ELK1 and GABPA regulate different gene networks to control MCF10A breast epithelial cell migration.,2012,10.1371/journal.pone.0049892,https://pubmed.ncbi.nlm.nih.gov/23284628/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,29915361,AMP kinase promotes glioblastoma bioenergetics and tumour growth.,2018,10.1038/s41556-018-0126-z,https://pubmed.ncbi.nlm.nih.gov/29915361/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,27911079,Trans-acting epigenetic effects of chromosomal aneuploidies: lessons from Down syndrome and mouse models.,2017,10.2217/epi-2016-0138,https://pubmed.ncbi.nlm.nih.gov/27911079/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABPA,ENSG00000154727,Unsafe,21705494,"GABP transcription factor is required for myeloid differentiation, in part, through its control of Gfi-1 expression.",2011,10.1182/blood-2010-07-298802,https://pubmed.ncbi.nlm.nih.gov/21705494/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,42450712,Transcriptomic Profiling of Canine Testicular Leydig Cell Tumors Uncovers Key Upregulated Gene Pathways.,2026,10.3390/ani16132005,https://pubmed.ncbi.nlm.nih.gov/42450712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,42034645,Single-cell profiling reveals distinct populations of tumor-associated macrophages and metastatic tumor cells in breast cancer brain metastasis.,2026,10.1038/s41419-026-08807-w,https://pubmed.ncbi.nlm.nih.gov/42034645/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,41999225,GABRB3 Gene Polymorphisms Influences the Analgesic Response to Acupuncture Treatment in Patients With Chronic Knee Pain: A Randomized Controlled Neuroimaging Transcriptomics Study.,2026,10.1096/fj.202600031r,https://pubmed.ncbi.nlm.nih.gov/41999225/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,40542409,Clinical and functional characterization of the GABRB3 p.Met80Val variant in early-onset epilepsy with long-term follow-up.,2025,10.1186/s13052-025-02046-z,https://pubmed.ncbi.nlm.nih.gov/40542409/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,41019480,"A &lt;i&gt;GABRB3&lt;/i&gt; mutation (c.5G&gt;A, p.Trp2*) in twins with generalized epilepsy with febrile seizures: A case report.",2025,10.3892/etm.2025.12963,https://pubmed.ncbi.nlm.nih.gov/41019480/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,41504861,Children with Autism Spectrum Disorder and Chronic Gastrointestinal Symptoms Have Alterations in Intestinal Neurotransmitter Pathways.,2026,10.1007/s10620-026-09667-2,https://pubmed.ncbi.nlm.nih.gov/41504861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,41118267,Zebrafish models of developmental epileptic encephalopathy accurately reflect clinical electrographic biomarkers.,2026,10.1111/epi.18681,https://pubmed.ncbi.nlm.nih.gov/41118267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,41523331,"Excitatory/Inhibitory balance in autism spectrum disorders: Integrating genetic, neurotransmitter and computational perspectives.",2025,10.3934/neuroscience.2025031,https://pubmed.ncbi.nlm.nih.gov/41523331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,41273056,Adolescent White Matter Maturation Mediates Epigenetic Associations With Cognitive Development.,2026,10.1002/dneu.70000,https://pubmed.ncbi.nlm.nih.gov/41273056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,40686338,Counterbalancing O-GlcNAcylation and STAT3 Phosphorylation in Ventral Tegmental Area Dopaminergic Neurons Mediates Behavioral Adaptations to Acute Restraint Stress.,2025,10.1002/advs.202502701,https://pubmed.ncbi.nlm.nih.gov/40686338/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,39737842,A novel de novo GABRA2 gene missense variant causing developmental epileptic encephalopathy in a Chinese patient.,2025,10.1002/acn3.52262,https://pubmed.ncbi.nlm.nih.gov/39737842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,41603155,Predictive value of seizure onset for gross motor dysfunction in individuals with pathogenic GABRB2 and GABRB3 variants.,2026,10.1002/epi.70096,https://pubmed.ncbi.nlm.nih.gov/41603155/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,41491842,"RO4938581, a GABA&lt;sub&gt;A&lt;/sub&gt;-α5 negative allosteric modulator rescued behavioral and EEG phenotypes of a mouse model of Dup15q syndrome.",2026,10.1038/s41380-025-03247-y,https://pubmed.ncbi.nlm.nih.gov/41491842/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,42274296,Cannabidiol reduces atypical absence seizures and epileptic spasms in a Gabrb3&lt;sup&gt;+/D120N&lt;/sup&gt; mouse model of Lennox-Gastaut syndrome.,2026,10.1002/epi4.70289,https://pubmed.ncbi.nlm.nih.gov/42274296/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,39711511,Proteomic signatures of Alzheimer's disease and Lewy body dementias: A comparative analysis.,2025,10.1002/alz.14375,https://pubmed.ncbi.nlm.nih.gov/39711511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,39595908,High Expression of GABAA Receptor β Subunit Genes Is Associated with Longer Overall Survival in Medulloblastoma.,2024,10.3390/brainsci14111146,https://pubmed.ncbi.nlm.nih.gov/39595908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,42546502,Accurate prediction of gain- and loss-of-function missense variants in GABA&lt;sub&gt;A&lt;/sub&gt; receptors.,2026,10.1016/j.ebiom.2026.106417,https://pubmed.ncbi.nlm.nih.gov/42546502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,42017314,Collapse of feed-forward inhibition underpins hyperexcitability in GABAA gain-of-function epilepsy.,2026,10.1093/brain/awag119,https://pubmed.ncbi.nlm.nih.gov/42017314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,38287309,Integrated analysis identifies GABRB3 as a biomarker in prostate cancer.,2024,10.1186/s12920-024-01816-8,https://pubmed.ncbi.nlm.nih.gov/38287309/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,41630268,"Adjunctive cannabidiol in intractable pediatric epilepsy: A retrospective study on tolerability, efficacy, and safety across genetic and nongenetic etiologies.",2026,10.1097/md.0000000000047425,https://pubmed.ncbi.nlm.nih.gov/41630268/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,42679582,Structure-dependent visual toxic mechanisms of benzothiazoles in zebrafish larvae (Danio rerio).,2026,10.1016/j.jhazmat.2026.143464,https://pubmed.ncbi.nlm.nih.gov/42679582/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,40136528,Neural Excitatory/Inhibitory Imbalance in Motor Aging: From Genetic Mechanisms to Therapeutic Challenges.,2025,10.3390/biology14030272,https://pubmed.ncbi.nlm.nih.gov/40136528/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,42158950,Employing zebrafish to understand genetic drivers of epilepsy-related comorbid behaviors.,2026,10.3389/fphar.2026.1781517,https://pubmed.ncbi.nlm.nih.gov/42158950/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,37176165,GABA&lt;sub&gt;A&lt;/sub&gt; Receptor β3 Subunit Mutation N328D Heterozygous Knock-in Mice Have Lennox-Gastaut Syndrome.,2023,10.3390/ijms24098458,https://pubmed.ncbi.nlm.nih.gov/37176165/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,36495145,Heterozygous GABAA receptor β3 subunit N110D knock-in mice have epileptic spasms.,2023,10.1111/epi.17470,https://pubmed.ncbi.nlm.nih.gov/36495145/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,36446382,Gabrb3 is required for the functional integration of pyramidal neuron subtypes in the somatosensory cortex.,2023,10.1016/j.neuron.2022.10.037,https://pubmed.ncbi.nlm.nih.gov/36446382/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,40993075,Genetic and Epigenetic Approaches to Opioid Use Disorder.,2025,10.1017/erm.2025.10024,https://pubmed.ncbi.nlm.nih.gov/40993075/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,35318369,"Gabrb3 endothelial cell-specific knockout mice display abnormal blood flow, hypertension, and behavioral dysfunction.",2022,10.1038/s41598-022-08806-9,https://pubmed.ncbi.nlm.nih.gov/35318369/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,40242660,A chronopharmacological comparison of ciprofol and propofol: focus on sedation and side effects.,2025,10.3389/fnmol.2025.1567453,https://pubmed.ncbi.nlm.nih.gov/40242660/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,36077081,Variable Expression of GABAA Receptor Subunit Gamma 2 Mutation in a Nuclear Family Displaying Developmental and Encephalopathic Phenotype.,2022,10.3390/ijms23179683,https://pubmed.ncbi.nlm.nih.gov/36077081/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRB3,ENSG00000166206,Unsafe,35799789,Characterization of Different Subtypes of Immune Cell Infiltration in Glioblastoma to Aid Immunotherapy.,2022,10.3389/fimmu.2022.799509,https://pubmed.ncbi.nlm.nih.gov/35799789/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,42151442,MSK1 mediates BDNF-dependent MeCP2-S421 phosphorylation in postnatal striatal development and psychiatric-relevant behaviours.,2026,10.1038/s41380-026-03630-3,https://pubmed.ncbi.nlm.nih.gov/42151442/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,41491842,"RO4938581, a GABA&lt;sub&gt;A&lt;/sub&gt;-α5 negative allosteric modulator rescued behavioral and EEG phenotypes of a mouse model of Dup15q syndrome.",2026,10.1038/s41380-025-03247-y,https://pubmed.ncbi.nlm.nih.gov/41491842/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,41023051,Distinctive GABA A receptor subunit expression modulates cell specific EMT and functional responses in glioblastoma breast and ovarian cancer.,2025,10.1038/s41598-025-18894-y,https://pubmed.ncbi.nlm.nih.gov/41023051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,38388464,Paternal cocaine-seeking motivation defines offspring's vulnerability to addiction by down-regulating GABAergic GABRG3 in the ventral tegmental area.,2024,10.1038/s41398-024-02835-w,https://pubmed.ncbi.nlm.nih.gov/38388464/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,40999355,Genomic diversity in Chinese Holstein cattle and genome-wide association study for body conformation traits.,2025,10.1186/s12864-025-12002-0,https://pubmed.ncbi.nlm.nih.gov/40999355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,39564730,"Blood Plasma Methylated DNA Markers in the Detection of Lymphoma: Discovery, Validation, and Clinical Pilot.",2025,10.1002/ajh.27533,https://pubmed.ncbi.nlm.nih.gov/39564730/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,40862667,"Open-Field Blast Injury Disrupts Corneal Gene Expression Linked to Ion Transport, Sensory Perception, and Neural Signaling.",2025,10.1167/iovs.66.11.68,https://pubmed.ncbi.nlm.nih.gov/40862667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,41375450,Genome-Wide Egg Hunt: Unhiding Candidate Genes for Egg Component Traits in Layers of an F&lt;sub&gt;2&lt;/sub&gt; Resource Population.,2025,10.3390/ani15233391,https://pubmed.ncbi.nlm.nih.gov/41375450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,35403940,SNP-PCR genotyping links alterations in the GABAA receptor (GABRG3: rs208129) and RELN (rs73670) genes to autism spectrum disorder among peadiatric Iraqi Arabs.,2022,10.1007/s11033-022-07388-z,https://pubmed.ncbi.nlm.nih.gov/35403940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,40315019,Single-nucleus RNA sequencing of rostral ventromedial medulla in mice with trigeminal neuralgia.,2026,10.1080/00207454.2025.2499863,https://pubmed.ncbi.nlm.nih.gov/40315019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,40890164,Identification of candidate gene networks affecting the number of somatic cells count and milk production in Iranian Holstein cows using Genome-wide association study.,2025,10.1038/s41598-025-09103-x,https://pubmed.ncbi.nlm.nih.gov/40890164/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,36943547,Gamma-Aminobutyric Acid Type A Receptor Variants are Associated with Autism Spectrum Disorders.,2023,10.1007/s12031-023-02113-2,https://pubmed.ncbi.nlm.nih.gov/36943547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,38674362,Genetic Alterations in a Large Population of Italian Patients Affected by Neurodevelopmental Disorders.,2024,10.3390/genes15040427,https://pubmed.ncbi.nlm.nih.gov/38674362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,37672226,Genes positively regulated by Mef2c in cortical neurons are enriched for common genetic variation associated with IQ and educational attainment.,2023,10.1093/hmg/ddad142,https://pubmed.ncbi.nlm.nih.gov/37672226/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,37019319,"Association of GABRG3, GABRB3, HTR2A gene variants with autism spectrum disorder.",2023,10.1016/j.gene.2023.147399,https://pubmed.ncbi.nlm.nih.gov/37019319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,34779508,Expanding the clinico-molecular spectrum of Angelman syndrome phenotype with the GABRG3 gene: Evidence from methylation and sequencing studies.,2022,10.1111/ahg.12449,https://pubmed.ncbi.nlm.nih.gov/34779508/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,34530807,"An association study in the Taiwan Biobank elicits the GABAA receptor genes GABRB3, GABRA5, and GABRG3 as candidate loci for sleep duration in the Taiwanese population.",2021,10.1186/s12920-021-01083-x,https://pubmed.ncbi.nlm.nih.gov/34530807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,37658353,Genome-wide association study of abnormal elevation of ALT in patients exposed to atabecestat.,2023,10.1186/s12864-023-09625-6,https://pubmed.ncbi.nlm.nih.gov/37658353/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,30108208,Association study and mutation sequencing of genes on chromosome 15q11-q13 identified GABRG3 as a susceptibility gene for autism in Chinese Han population.,2018,10.1038/s41398-018-0197-4,https://pubmed.ncbi.nlm.nih.gov/30108208/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,37212113,Aberrant Expression of GABA-Related Genes in the Hippocampus of 3xTg-AD Model Mice from the Early to End Stages of Alzheimer's Disease.,2023,10.3233/jad-230078,https://pubmed.ncbi.nlm.nih.gov/37212113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,35624665,Genome-Wide Association Study of Fluorescent Oxidation Products Accounting for Tobacco Smoking Status in Adults from the French EGEA Study.,2022,10.3390/antiox11050802,https://pubmed.ncbi.nlm.nih.gov/35624665/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,35456477,Electrophysiological and Behavioral Evidence for Hyper- and Hyposensitivity in Rare Genetic Syndromes Associated with Autism.,2022,10.3390/genes13040671,https://pubmed.ncbi.nlm.nih.gov/35456477/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,32606685,Low-Dose Exposure of Silica Nanoparticles Induces Neurotoxicity via Neuroactive Ligand-Receptor Interaction Signaling Pathway in Zebrafish Embryos.,2020,10.2147/ijn.s254480,https://pubmed.ncbi.nlm.nih.gov/32606685/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,32914196,A panel of extracellular vesicle long noncoding RNAs in seminal plasma for predicting testicular spermatozoa in nonobstructive azoospermia patients.,2020,10.1093/humrep/deaa184,https://pubmed.ncbi.nlm.nih.gov/32914196/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,31469419,Identification of novel epithelial ovarian cancer loci in women of African ancestry.,2020,10.1002/ijc.32653,https://pubmed.ncbi.nlm.nih.gov/31469419/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,29538177,Genetic Determinants for Leisure-Time Physical Activity.,2018,10.1249/mss.0000000000001607,https://pubmed.ncbi.nlm.nih.gov/29538177/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,23663378,"Paradoxical worsening of seizure activity with pregabalin in an adult with isodicentric 15 (IDIC-15) syndrome involving duplications of the GABRB3, GABRA5 and GABRG3 genes.",2013,10.1186/1471-2377-13-43,https://pubmed.ncbi.nlm.nih.gov/23663378/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,22253714,GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats.,2012,10.1371/journal.pone.0029369,https://pubmed.ncbi.nlm.nih.gov/22253714/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRG3,ENSG00000182256,Unsafe,8719414,Expression and pharmacology of human GABAA receptors containing gamma 3 subunits.,1995,10.1016/0922-4106(95)90070-5,https://pubmed.ncbi.nlm.nih.gov/8719414/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,40862667,"Open-Field Blast Injury Disrupts Corneal Gene Expression Linked to Ion Transport, Sensory Perception, and Neural Signaling.",2025,10.1167/iovs.66.11.68,https://pubmed.ncbi.nlm.nih.gov/40862667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,38886664,Selection signatures of wool color in Gangba sheep revealed by genome-wide SNP discovery.,2024,10.1186/s12864-024-10464-2,https://pubmed.ncbi.nlm.nih.gov/38886664/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,37414911,Genome-wide DNA methylation analysis in schizophrenia with tardive dyskinesia: a preliminary study.,2023,10.1007/s13258-023-01414-5,https://pubmed.ncbi.nlm.nih.gov/37414911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,31451629,The GABA receptor GABRR1 is expressed on and functional in hematopoietic stem cells and megakaryocyte progenitors.,2019,10.1073/pnas.1906251116,https://pubmed.ncbi.nlm.nih.gov/31451629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,31444245,Maintenance of Melanocyte Stem Cell Quiescence by GABA-A Signaling in Larval Zebrafish.,2019,10.1534/genetics.119.302416,https://pubmed.ncbi.nlm.nih.gov/31444245/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,34448502,Adipose-derived stem cell-derived extracellular vesicles inhibit neuroblastoma growth by regulating GABBR1 activity through LINC00622-mediated transcription factor AR.,2022,10.1002/jlb.1mia0321-164r,https://pubmed.ncbi.nlm.nih.gov/34448502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,36714595,"Overweight/obesity-related transcriptomic signature as a correlate of clinical outcome, immune microenvironment, and treatment response in hepatocellular carcinoma.",2022,10.3389/fendo.2022.1061091,https://pubmed.ncbi.nlm.nih.gov/36714595/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,35798032,Genome and chromosome wide association studies for growth traits in Simmental and Simbrah cattle.,2023,10.5713/ab.21.0517,https://pubmed.ncbi.nlm.nih.gov/35798032/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,31789422,Identification of novel diagnostic and prognostic biomarkers for hepatocellular carcinoma.,2020,10.3892/or.2019.7415,https://pubmed.ncbi.nlm.nih.gov/31789422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,28699326,Gamma-Aminobutyric Acid (Gaba) Receptors Rho (Gabrr) Gene Polymorphisms and Risk for Migraine.,2017,10.1111/head.13122,https://pubmed.ncbi.nlm.nih.gov/28699326/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,27959334,Implication of NOTCH1 gene in susceptibility to anxiety and depression among sexual abuse victims.,2016,10.1038/tp.2016.248,https://pubmed.ncbi.nlm.nih.gov/27959334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,29720720,Gamma-aminobutyric acid (GABA) receptors genes polymorphisms and risk for restless legs syndrome.,2018,10.1038/s41397-018-0023-7,https://pubmed.ncbi.nlm.nih.gov/29720720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,31646556,A comprehensive understanding of ovarian carcinoma survival prognosis by novel biomarkers.,2019,10.26355/eurrev_201910_19136,https://pubmed.ncbi.nlm.nih.gov/31646556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,34609116,Genetic associated complications of type 2 diabetes mellitus.,2022,10.23736/s0031-0808.21.04285-3,https://pubmed.ncbi.nlm.nih.gov/34609116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,32917921,Single-step genome-wide association study for social genetic effects and direct genetic effects on growth in Landrace pigs.,2020,10.1038/s41598-020-71647-x,https://pubmed.ncbi.nlm.nih.gov/32917921/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,29445327,"Missense Gamma-Aminobutyric Acid Receptor Polymorphisms Are Associated with Reaction Time, Motor Time, and Ethanol Effects in Vivo.",2018,10.3389/fncel.2018.00010,https://pubmed.ncbi.nlm.nih.gov/29445327/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,27020472,Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.,2016,10.1038/ncomms11008,https://pubmed.ncbi.nlm.nih.gov/27020472/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,29703844,A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.,2018,10.2337/db17-0914,https://pubmed.ncbi.nlm.nih.gov/29703844/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,19536785,"GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence.",2010,10.1002/ajmg.b.30995,https://pubmed.ncbi.nlm.nih.gov/19536785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,20820800,Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor.,2011,10.1007/s00415-010-5708-z,https://pubmed.ncbi.nlm.nih.gov/20820800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,32269590,"Genome-Wide Association of Genetic Variants With Refraction, Axial Length, and Corneal Curvature: A Longitudinal Study of Chinese Schoolchildren.",2020,10.3389/fgene.2020.00276,https://pubmed.ncbi.nlm.nih.gov/32269590/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,9585594,"A major locus for autosomal recessive retinitis pigmentosa on 6q, determined by homozygosity mapping of chromosomal regions that contain gamma-aminobutyric acid-receptor clusters.",1998,10.1086/301866,https://pubmed.ncbi.nlm.nih.gov/9585594/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR1,ENSG00000146276,Unsafe,1849271,Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.,1991,10.1073/pnas.88.7.2673,https://pubmed.ncbi.nlm.nih.gov/1849271/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR3,ENSG00000183185,Unsafe,41023051,Distinctive GABA A receptor subunit expression modulates cell specific EMT and functional responses in glioblastoma breast and ovarian cancer.,2025,10.1038/s41598-025-18894-y,https://pubmed.ncbi.nlm.nih.gov/41023051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR3,ENSG00000183185,Unsafe,34099874,Functional analysis of distinct populations of subthalamic nucleus neurons on Parkinson's disease and OCD-like behaviors in mice.,2021,10.1038/s41380-021-01162-6,https://pubmed.ncbi.nlm.nih.gov/34099874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR3,ENSG00000183185,Unsafe,35798032,Genome and chromosome wide association studies for growth traits in Simmental and Simbrah cattle.,2023,10.5713/ab.21.0517,https://pubmed.ncbi.nlm.nih.gov/35798032/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR3,ENSG00000183185,Unsafe,29720720,Gamma-aminobutyric acid (GABA) receptors genes polymorphisms and risk for restless legs syndrome.,2018,10.1038/s41397-018-0023-7,https://pubmed.ncbi.nlm.nih.gov/29720720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR3,ENSG00000183185,Unsafe,28699326,Gamma-Aminobutyric Acid (Gaba) Receptors Rho (Gabrr) Gene Polymorphisms and Risk for Migraine.,2017,10.1111/head.13122,https://pubmed.ncbi.nlm.nih.gov/28699326/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR3,ENSG00000183185,Unsafe,29445327,"Missense Gamma-Aminobutyric Acid Receptor Polymorphisms Are Associated with Reaction Time, Motor Time, and Ethanol Effects in Vivo.",2018,10.3389/fncel.2018.00010,https://pubmed.ncbi.nlm.nih.gov/29445327/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR3,ENSG00000183185,Unsafe,24363211,Peripherally restricted acute phase response to a viral mimic alters hippocampal gene expression.,2014,10.1007/s11011-013-9471-6,https://pubmed.ncbi.nlm.nih.gov/24363211/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR3,ENSG00000183185,Unsafe,20820800,Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor.,2011,10.1007/s00415-010-5708-z,https://pubmed.ncbi.nlm.nih.gov/20820800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR3,ENSG00000183185,Unsafe,28026009,Transcriptomic profiling of platelet senescence and platelet extracellular vesicles.,2017,10.1111/trf.13896,https://pubmed.ncbi.nlm.nih.gov/28026009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR3,ENSG00000183185,Unsafe,23376243,Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing.,2013,10.1016/j.mad.2013.01.005,https://pubmed.ncbi.nlm.nih.gov/23376243/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GABRR3,ENSG00000183185,Unsafe,19078961,Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.,2010,10.1038/mp.2008.66,https://pubmed.ncbi.nlm.nih.gov/19078961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE12F,ENSG00000236362,Unsafe,37106775,Electrostatic Complementarities of Glioblastoma-Resident T-Cell Receptors and Cancer Testis Antigens Linked to Poor Outcomes and High Levels of Sphingosine Kinase-2 Expression.,2023,10.3390/biology12040575,https://pubmed.ncbi.nlm.nih.gov/37106775/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE12F,ENSG00000236362,Unsafe,38217083,An integrative analysis of GEO data to identify possible therapeutic biomarkers of prostate cancer and targeting potential protein through &lt;i&gt;Zea mays&lt;/i&gt; phytochemicals by virtual screening approaches.,2025,10.1080/07391102.2023.2283163,https://pubmed.ncbi.nlm.nih.gov/38217083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE12G,ENSG00000215269,Unsafe,38217083,An integrative analysis of GEO data to identify possible therapeutic biomarkers of prostate cancer and targeting potential protein through &lt;i&gt;Zea mays&lt;/i&gt; phytochemicals by virtual screening approaches.,2025,10.1080/07391102.2023.2283163,https://pubmed.ncbi.nlm.nih.gov/38217083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE12J,ENSG00000224659,Unsafe,33601878,Identification of hub genes and pathways in the development of gastric cancer by gene co‑expression network analysis.,2021,10.23812/20-478-a,https://pubmed.ncbi.nlm.nih.gov/33601878/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE12J,ENSG00000224659,Unsafe,29167000,[Study on Genetype in Lung Squamous Carcinoma by High-throughput of 
Transcriptome Sequence].,2017,10.3779/j.issn.1009-3419.2017.11.01,https://pubmed.ncbi.nlm.nih.gov/29167000/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE2E,ENSG00000275113,Unsafe,38217083,An integrative analysis of GEO data to identify possible therapeutic biomarkers of prostate cancer and targeting potential protein through &lt;i&gt;Zea mays&lt;/i&gt; phytochemicals by virtual screening approaches.,2025,10.1080/07391102.2023.2283163,https://pubmed.ncbi.nlm.nih.gov/38217083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAGE2E,ENSG00000275113,Unsafe,34386035,Predictive Biomarkers of Dicycloplatin Resistance or Susceptibility in Prostate Cancer.,2021,10.3389/fgene.2021.669605,https://pubmed.ncbi.nlm.nih.gov/34386035/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,40962834,GALNTL5 binds GalNAc and is required for migration through the uterotubal junction and sperm-zona pellucida binding.,2025,10.1038/s41467-025-63805-4,https://pubmed.ncbi.nlm.nih.gov/40962834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,41630042,Mechanistic insights into EOC-PMCs-Induced macrophage polarization via the Galnt15-PPARγ pathway.,2026,10.1186/s13048-026-02002-3,https://pubmed.ncbi.nlm.nih.gov/41630042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,42892435,"Pathogenic variants in GALNT3, GALNT8, and GALNTL5 are associated with distinct sperm defects in human asthenoteratozoospermia.",2026,10.1016/j.fertnstert.2026.10.009,https://pubmed.ncbi.nlm.nih.gov/42892435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,39695134,"GALNTL5, which is restricted to mouse spermatids, impairs endoplasmic reticulum (ER) function through direct interaction with ER chaperone proteins.",2024,10.1038/s41420-024-02252-4,https://pubmed.ncbi.nlm.nih.gov/39695134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,42230027,Structure characteristics of a polysaccharide isolated from safflower and its neuroprotective effects against cerebral ischemia/reperfusion injury by LASSO regression analysis of transcriptomic and metabolomic data.,2026,10.1016/j.carbpol.2026.125425,https://pubmed.ncbi.nlm.nih.gov/42230027/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,39209927,Polypeptide N-acetylgalactosaminyltransferase-15 regulates adipogenesis in human SGBS cells.,2024,10.1038/s41598-024-70930-5,https://pubmed.ncbi.nlm.nih.gov/39209927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,40485044,Identification of new candidate genes affecting drip loss in pigs based on genomics and transcriptomics data.,2025,10.1093/jas/skaf177,https://pubmed.ncbi.nlm.nih.gov/40485044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,40723553,"The Effect of rs80860411 Polymorphism on Fattening, Slaughter, and Pork Quality Traits in Polish Large White and Pulawska Breeds.",2025,10.3390/ani15142090,https://pubmed.ncbi.nlm.nih.gov/40723553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,40814892,Comprehensive Analysis of Glycosyltransferase-Related Genes Reveals their Prognostic and Therapeutic Implications in Stomach Adenocarcinoma.,2026,10.2174/0113892037388672250728071209,https://pubmed.ncbi.nlm.nih.gov/40814892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,41585535,Reciprocal regulation of rumen microbiota and epithelial genes in response to small peptide supplementation for feed efficiency in beef cattle.,2025,10.3389/fvets.2025.1714827,https://pubmed.ncbi.nlm.nih.gov/41585535/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,33426787,Combined RNA/tissue profiling identifies novel Cancer/testis genes.,2021,10.1002/1878-0261.12900,https://pubmed.ncbi.nlm.nih.gov/33426787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,39764877,"The hematopoietic function, histological characteristics, and transcriptome profiling of Wanxi white geese ovary during nesting and late-laying stages.",2025,10.1016/j.psj.2025.104764,https://pubmed.ncbi.nlm.nih.gov/39764877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,39816229,An 11-gene glycosyltransferases-related model for the prognosis of patients with bladder urothelial carcinoma: development and validation based on TCGA and GEO datasets.,2024,10.21037/tau-2024-632,https://pubmed.ncbi.nlm.nih.gov/39816229/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,38840920,GLT8D2 is a prognostic biomarker and regulator of immune cell infiltration in gastric cancer.,2024,10.3389/fimmu.2024.1370367,https://pubmed.ncbi.nlm.nih.gov/38840920/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,27173285,A novel splice variant of the bovine GALNTL5 gene identified in Chinese Holstein bull testis tissue and its mRNA expression.,2016,10.4238/gmr.15027723,https://pubmed.ncbi.nlm.nih.gov/27173285/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,36769150,Overnight Corticosterone and Gene Expression in Mouse Hippocampus: Time Course during Resting Period.,2023,10.3390/ijms24032828,https://pubmed.ncbi.nlm.nih.gov/36769150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,36139132,"Comparative Transcriptomic Analysis of mRNAs, miRNAs and lncRNAs in the Longissimus dorsi Muscles between Fat-Type and Lean-Type Pigs.",2022,10.3390/biom12091294,https://pubmed.ncbi.nlm.nih.gov/36139132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,24398516,A heterozygous mutation of GALNTL5 affects male infertility with impairment of sperm motility.,2014,10.1073/pnas.1310777111,https://pubmed.ncbi.nlm.nih.gov/24398516/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,38347496,Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis.,2024,10.1186/s12711-024-00882-x,https://pubmed.ncbi.nlm.nih.gov/38347496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,38664359,Evaluation of an Updated Gene Panel as a Diagnostic Tool for Both Male and Female Infertility.,2024,10.1007/s43032-024-01553-4,https://pubmed.ncbi.nlm.nih.gov/38664359/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,35046993,Identification of Five Cytotoxicity-Related Genes Involved in the Progression of Triple-Negative Breast Cancer.,2021,10.3389/fgene.2021.723477,https://pubmed.ncbi.nlm.nih.gov/35046993/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GALNTL5,ENSG00000106648,Unsafe,28720099,Association between genome-wide copy number variation and arsenic-induced skin lesions: a prospective study.,2017,10.1186/s12940-017-0283-8,https://pubmed.ncbi.nlm.nih.gov/28720099/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,41843882,Sperm-Specific Glyceraldehyde-3-Phosphate Dehydrogenase and Energy Metabolism in Melanoma Cells.,2026,10.1134/s0006297925603417,https://pubmed.ncbi.nlm.nih.gov/41843882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,42655810,Screening of Stable Reference Genes in &lt;i&gt;Solea senegalensis&lt;/i&gt; Juveniles for Nervous Necrosis Virus (NNV) Vaccination Assays.,2026,10.3390/vetsci13080790,https://pubmed.ncbi.nlm.nih.gov/42655810/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,42822119,All about sperm-specific GAPDH: A key enzyme in sperm energy metabolism and potential biomarker for sperm motility and male fertility.,2026,10.1016/j.repbio.2026.101291,https://pubmed.ncbi.nlm.nih.gov/42822119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,42236530,Identification and validation of reference genes for quantitative real-time PCR in Corydalis saxicola under various abiotic stresses.,2026,10.1038/s41598-026-54993-0,https://pubmed.ncbi.nlm.nih.gov/42236530/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,41793517,Dysregulated methylation of the human BOLL promoter hinders germ cell development from spermatogonia to spermatids.,2026,10.1007/s11033-026-11633-0,https://pubmed.ncbi.nlm.nih.gov/41793517/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,37711387,The role of sperm-specific glyceraldehyde-3-phosphate dehydrogenase in the development of pathologies-from asthenozoospermia to carcinogenesis.,2023,10.3389/fmolb.2023.1256963,https://pubmed.ncbi.nlm.nih.gov/37711387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,41484952,Genome-wide identification of GAPDH gene family and functional analysis of CaGAPC2-mediated autophagy during BWYV infection in pepper.,2026,10.1186/s12864-025-12436-6,https://pubmed.ncbi.nlm.nih.gov/41484952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,39587844,Localization and expression analysis of sperm-specific glyceraldehyde 3-phosphate dehydrogenase in bull spermatozoa with contrasting sperm motility.,2025,10.1111/andr.13810,https://pubmed.ncbi.nlm.nih.gov/39587844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,41475355,Exploration of real-time fluorescence quantitative PCR by analyzing effective reference genes in Galleria mellonella (Lepidoptera: Pyralidae).,2025,10.1093/jisesa/ieaf103,https://pubmed.ncbi.nlm.nih.gov/41475355/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,39826747,Functional characterization of GAPDH2 through overexpression and dsRNA-mediated RNA interference in Synechocystis.,2025,10.1016/j.ijbiomac.2025.139967,https://pubmed.ncbi.nlm.nih.gov/39826747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,40303431,Beyond glycolysis: multifunctional roles of glyceraldehyde-3-phosphate dehydrogenases in plants.,2025,10.1093/hr/uhaf070,https://pubmed.ncbi.nlm.nih.gov/40303431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,35149585,A Short Isoform of Spermatogenic Enzyme GAPDHS Functions as a Metabolic Switch and Limits Metastasis in Melanoma.,2022,10.1158/0008-5472.can-21-2062,https://pubmed.ncbi.nlm.nih.gov/35149585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,41508175,[Reference genes screening and expression analysis of genes involved in terpenoid biosynthesis in Curcuma kwangsiensis].,2025,10.19540/j.cnki.cjcmm.20250607.103,https://pubmed.ncbi.nlm.nih.gov/41508175/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,41240463,TMT-based proteomic analysis reveals key proteins involved in cryoinjury of Nubian goat spermatozoa.,2025,10.1016/j.cryobiol.2025.105542,https://pubmed.ncbi.nlm.nih.gov/41240463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,39156775,Key genes and regulatory networks for diabetic retinopathy based on hypoxia-related genes: a bioinformatics analysis.,2024,10.18240/ijo.2024.08.04,https://pubmed.ncbi.nlm.nih.gov/39156775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,41045737,Lambda-cyhalothrin exposure enhances the development of atherosclerosis in ApoE&lt;sup&gt;-/-&lt;/sup&gt; mice.,2025,10.1016/j.ecoenv.2025.119165,https://pubmed.ncbi.nlm.nih.gov/41045737/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,36672976,Sorted Bulls' X-Chromosome-Bearing Spermatozoa Show Increased GAPDHS Activity Correlating with Motility.,2023,10.3390/genes14010235,https://pubmed.ncbi.nlm.nih.gov/36672976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,36306217,Testis-specific serine kinase 3 is required for sperm morphogenesis and male fertility.,2023,10.1111/andr.13314,https://pubmed.ncbi.nlm.nih.gov/36306217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,41534738,"Combined histopathological, immunoenzymatic and transcriptomic analyses reveal the immune response mechanisms of silver pomfret infected by Vibrio parahaemolyticus.",2026,10.1016/j.fsi.2026.111124,https://pubmed.ncbi.nlm.nih.gov/41534738/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,40046063,A novel glycolysis-related gene signature for predicting prognosis and immunotherapy efficacy in breast cancer.,2025,10.3389/fimmu.2025.1512859,https://pubmed.ncbi.nlm.nih.gov/40046063/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,36449552,Two apicoplast dwelling glycolytic enzymes provide key substrates for metabolic pathways in the apicoplast and are critical for Toxoplasma growth.,2022,10.1371/journal.ppat.1011009,https://pubmed.ncbi.nlm.nih.gov/36449552/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,39134555,Plant viruses exploit insect salivary GAPDH to modulate plant defenses.,2024,10.1038/s41467-024-51369-8,https://pubmed.ncbi.nlm.nih.gov/39134555/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,34741939,Multi-omics analyses reveal the mechanisms of Arsenic-induced male reproductive toxicity in mice.,2022,10.1016/j.jhazmat.2021.127548,https://pubmed.ncbi.nlm.nih.gov/34741939/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,37141450,Advances in non-hormonal male contraception targeting sperm motility.,2023,10.1093/humupd/dmad008,https://pubmed.ncbi.nlm.nih.gov/37141450/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,33058314,"Chlamydia trachomatis glyceraldehyde 3-phosphate dehydrogenase: Enzyme kinetics, high-resolution crystal structure, and plasminogen binding.",2020,10.1002/pro.3975,https://pubmed.ncbi.nlm.nih.gov/33058314/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,29025010,"Sperm function, protein phosphorylation, and metabolism differ in mice lacking successive sperm-specific glycolytic enzymes.",2017,10.1093/biolre/iox103,https://pubmed.ncbi.nlm.nih.gov/29025010/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,25308277,Chemical targeting of GAPDH moonlighting function in cancer cells reveals its role in tubulin regulation.,2014,10.1016/j.chembiol.2014.08.017,https://pubmed.ncbi.nlm.nih.gov/25308277/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,26660717,"The proline-rich region of glyceraldehyde-3-phosphate dehydrogenase from human sperm may bind SH3 domains, as revealed by a bioinformatic study of low-complexity protein segments.",2016,10.1002/mrd.22606,https://pubmed.ncbi.nlm.nih.gov/26660717/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,26921398,"Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme.",2016,10.1093/molehr/gaw016,https://pubmed.ncbi.nlm.nih.gov/26921398/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,26984398,Genome-wide identification and characterization of Glyceraldehyde-3-phosphate dehydrogenase genes family in wheat (Triticum aestivum).,2016,10.1186/s12864-016-2527-3,https://pubmed.ncbi.nlm.nih.gov/26984398/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,22017642,Secreted glyceraldehyde-3-phosphate dehydrogenase as a broad spectrum vaccine candidate against microbial infection in aquaculture.,2012,10.1111/j.1472-765x.2011.03164.x,https://pubmed.ncbi.nlm.nih.gov/22017642/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,31743950,"The formation of hybrid complexes between isoenzymes of glyceraldehyde-3-phosphate dehydrogenase regulates its aggregation state, the glycolytic activity and sphingolipid status in Saccharomyces cerevisiae.",2020,10.1111/1751-7915.13513,https://pubmed.ncbi.nlm.nih.gov/31743950/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,25286935,Structure of Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase holoenzyme reveals a novel surface.,2014,10.1107/s2053230x14019517,https://pubmed.ncbi.nlm.nih.gov/25286935/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,25742975,Vaccine efficacy of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from Edwardsiella ictaluri against E. tarda in tilapia.,2014,10.2323/jgam.60.241,https://pubmed.ncbi.nlm.nih.gov/25742975/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAPDHS,ENSG00000105679,Unsafe,23213680,[Inhibitory effect of (S)-chlorohydrin on rat sperm motility and hyperactivation].,2012,,https://pubmed.ncbi.nlm.nih.gov/23213680/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN1A,ENSG00000205085,Unsafe,38935810,Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads.,2024,10.1371/journal.pgen.1011337,https://pubmed.ncbi.nlm.nih.gov/38935810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN1A,ENSG00000205085,Unsafe,34714330,FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice.,2021,10.1242/dev.199644,https://pubmed.ncbi.nlm.nih.gov/34714330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN1A,ENSG00000205085,Unsafe,33450964,Differential DNA Methylation in Prostate Tumors from Puerto Rican Men.,2021,10.3390/ijms22020733,https://pubmed.ncbi.nlm.nih.gov/33450964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN1A,ENSG00000205085,Unsafe,23465480,"Commentary on ""predicting metastasized seminoma using gene expression."" Ruf CG, Linbecker M, Port M, Riecke A, Schmelz HU, Wagner W, Meineke V, Abend M, Department of Urology, Federal Armed Forces Hospital, Hamburg, Germany: BJU Int 2012;110:E14.",2013,10.1016/j.urolonc.2013.02.009,https://pubmed.ncbi.nlm.nih.gov/23465480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN1A,ENSG00000205085,Unsafe,22243760,Predicting metastasized seminoma using gene expression.,2012,10.1111/j.1464-410x.2011.10778.x,https://pubmed.ncbi.nlm.nih.gov/22243760/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN4,ENSG00000162771,Unsafe,38935810,Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads.,2024,10.1371/journal.pgen.1011337,https://pubmed.ncbi.nlm.nih.gov/38935810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN4,ENSG00000162771,Unsafe,29969634,Genetic variants with gene regulatory effects are associated with diisocyanate-induced asthma.,2018,10.1016/j.jaci.2018.06.022,https://pubmed.ncbi.nlm.nih.gov/29969634/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN5A,ENSG00000142530,Unsafe,38935810,Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads.,2024,10.1371/journal.pgen.1011337,https://pubmed.ncbi.nlm.nih.gov/38935810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN5A,ENSG00000142530,Unsafe,36048437,Identification of 5 Potential Predictive Biomarkers for Alzheimer's Disease by Integrating the Unified Test for Molecular Signatures and Weighted Gene Coexpression Network Analysis.,2023,10.1093/gerona/glac179,https://pubmed.ncbi.nlm.nih.gov/36048437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GARIN5A,ENSG00000142530,Unsafe,29884787,Whole Exome Sequencing of Patients from Multicase Families with Systemic Lupus Erythematosus Identifies Multiple Rare Variants.,2018,10.1038/s41598-018-26274-y,https://pubmed.ncbi.nlm.nih.gov/29884787/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42898284,GART expression is associated with a proliferative and purine-metabolic ISC-like epithelial state in ulcerative colitis.,2026,10.3389/fimmu.2026.1913904,https://pubmed.ncbi.nlm.nih.gov/42898284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42188194,NPF-Driven &lt;i&gt;Gart&lt;/i&gt; Expression Fuels Gut Absorption and Modulates Feeding via a Negative Feedback Loop.,2026,10.3390/insects17050528,https://pubmed.ncbi.nlm.nih.gov/42188194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42668808,Identification and validation of novel platelet-related genes in ulcerative colitis using bioinformatics and machine learning strategies.,2026,10.7717/peerj.21655,https://pubmed.ncbi.nlm.nih.gov/42668808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42225708,Identification and validation of palmitoylation-associated biomarkers in major depressive disorder.,2026,10.1038/s41598-026-54509-w,https://pubmed.ncbi.nlm.nih.gov/42225708/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42031779,Identification of NFE2L2 as a key biomarker associated with pyroptosis in gliomas through bioinformatics and experiments.,2026,10.1038/s41598-026-43219-y,https://pubmed.ncbi.nlm.nih.gov/42031779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42874724,"Purine and citrate metabolism in urolithiasis and bladder cancer: An integrated genetic, gene-expression, and targeted metabolite analysis.",2026,10.1016/j.bbadis.2026.168500,https://pubmed.ncbi.nlm.nih.gov/42874724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42650051,Identification of Pyroptosis-Related Gene Signatures Associated with Predicted Immune-Cell Enrichment in Atrial Fibrillation.,2026,10.3390/genes17080858,https://pubmed.ncbi.nlm.nih.gov/42650051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,41136446,The impact of PANoptosis-related genes on immune profiles and subtype classification in ischemic stroke.,2025,10.1038/s41598-025-20997-5,https://pubmed.ncbi.nlm.nih.gov/41136446/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42332776,Development and validation of palmitoylation-related genes characteristics for prediction of prognosis and immune landscape in endometrial cancer.,2026,10.1186/s41065-026-00699-2,https://pubmed.ncbi.nlm.nih.gov/42332776/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42123585,Allogeneic Platelet-Rich Gel Supernatant Reprograms the Cytokine and Growth Factor Microenvironment in an Equine In Vitro Inflammatory Tendon System.,2026,10.3390/ijms27094006,https://pubmed.ncbi.nlm.nih.gov/42123585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42069724,Evaluation and expression-level verification of the prognostic value of palmitoylation-related genes in ovarian cancer.,2026,10.1038/s41598-026-50074-4,https://pubmed.ncbi.nlm.nih.gov/42069724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42703821,Gene Expression Dynamics and Network Analysis Reveal Key Molecular Pathways in Spermatogenic Progression from Spermatogonial Stem Cells to Round Spermatids.,2026,10.22074/ijfs.2025.2064261.1893,https://pubmed.ncbi.nlm.nih.gov/42703821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42623752,Nanoplastics exacerbate DSS-induced colitis via histone lactate axis.,2026,10.1016/j.ecoenv.2026.120688,https://pubmed.ncbi.nlm.nih.gov/42623752/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,41677975,Pan-cancer multi-omics dissection of podosome-related genes reveals their dual roles in tumor invasion and immune modulation.,2026,10.1007/s12672-026-04558-4,https://pubmed.ncbi.nlm.nih.gov/41677975/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,41473675,"Analysis of PANoptosis-related genes in septic cardiomyopathy by bioinformatics, machine learning and experimental validation.",2026,10.3892/etm.2025.13050,https://pubmed.ncbi.nlm.nih.gov/41473675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42218414,Exploring the functional role of palmitoylation genes in clear cell renal cell carcinoma and their impact on tumor microenvironment.,2026,10.1186/s12863-026-01443-5,https://pubmed.ncbi.nlm.nih.gov/42218414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42332538,Polyamine-related 4-gene prognostic signature in hepatocellular carcinoma.,2026,10.1097/md.0000000000049410,https://pubmed.ncbi.nlm.nih.gov/42332538/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42196106,Multivariate Temporal Inflammatory-Regenerative Signatures of Bovine Platelet-Rich Gel Supernatants Under Different Storage Temperatures.,2026,10.3390/gels12050422,https://pubmed.ncbi.nlm.nih.gov/42196106/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42172897,Exploration and validation of potential diagnostic biomarkers of PANoptosis in periodontitis using bioinformatics approaches.,2026,10.1016/j.bbrc.2026.153963,https://pubmed.ncbi.nlm.nih.gov/42172897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,41465897,Identification and experimental validation of biomarkers associated with paraptosis in meningioma.,2025,10.1097/md.0000000000047116,https://pubmed.ncbi.nlm.nih.gov/41465897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42856656,"A palmitoylation-associated three-gene signature predicts prognosis, immune features, and drug sensitivity in gastric cancer: functional validation of CTHRC1.",2026,10.3389/fimmu.2026.1893438,https://pubmed.ncbi.nlm.nih.gov/42856656/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42367221,"Based on comprehensive analysis of ScRNA-seq and bulk RNA-seq, identification of palmitoylation-related genes as biomarkers to evaluate prognosis and immune landscape in stomach adenocarcinoma.",2026,10.1007/s10616-026-01014-7,https://pubmed.ncbi.nlm.nih.gov/42367221/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,41967212,Licochalcone A from Ma-Xing-Shi-Gan decoction to prevent Asthma through the inhibition of ferroptosis CD4+ T Cell by GART/HSP90α signaling pathway.,2026,10.1016/j.intimp.2026.116549,https://pubmed.ncbi.nlm.nih.gov/41967212/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42079738,Integrated analysis identifies a palmitoylation-associated prognostic model (ACSM5/SKA3) for lung adenocarcinoma across multiple cohorts.,2026,10.7717/peerj.21160,https://pubmed.ncbi.nlm.nih.gov/42079738/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,41619135,A novel signature of palmitoylation for predicting prognosis and therapeutic response of hepatocellular carcinoma.,2026,10.1007/s12672-026-04544-w,https://pubmed.ncbi.nlm.nih.gov/41619135/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,41249490,Integrative multiomics analysis of platelet-related genes unveils molecular subtypes and prognostic signatures in acute myeloid leukemia.,2025,10.1038/s41698-025-01137-8,https://pubmed.ncbi.nlm.nih.gov/41249490/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,40805276,Advances in Bidirectional Therapy for Peritoneal Metastases: A Systematic Review of Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) Combined with Systemic Chemotherapy.,2025,10.3390/cancers17152580,https://pubmed.ncbi.nlm.nih.gov/40805276/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42355611,Pressurized Intraperitoneal Aerosol Chemotherapy for Platinum-Resistant Ovarian Cancer: A Systematic Review and Meta-Analysis of Clinical Outcomes.,2026,10.3390/jcm15124443,https://pubmed.ncbi.nlm.nih.gov/42355611/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,41438490,Development of Novel PANoptosis-Related Gene Signatures to Predict the Prognosis of Patients With Stomach Adenocarcinoma.,2025,10.1155/humu/5319444,https://pubmed.ncbi.nlm.nih.gov/41438490/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,41208987,Single-cell and machine learning-based pyroptosis-related gene signature predicts prognosis and immunotherapy response in glioblastoma.,2025,10.3389/fimmu.2025.1693940,https://pubmed.ncbi.nlm.nih.gov/41208987/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,41490727,Constructing a PANoptosis-based prognostic signature to evaluate the immune landscape and therapeutic response in clear cell renal cell carcinoma.,2025,10.1631/jzus.b2400132,https://pubmed.ncbi.nlm.nih.gov/41490727/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,41273616,A prognostic model derived from PANoptosis-associated subtypes unveils immunological features and therapeutic vulnerabilities in cervical cancer.,2025,10.1007/s12672-025-04115-5,https://pubmed.ncbi.nlm.nih.gov/41273616/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,42023218,"Integrating bulk, single-cell, and spatial transcriptomics to identify a novel pyroptosis-related gene signature for predicting prognosis and tumor immune landscape in triple-negative breast cancer.",2026,10.3389/fimmu.2026.1743222,https://pubmed.ncbi.nlm.nih.gov/42023218/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GART,ENSG00000159131,Unsafe,41004487,Multi-omics analysis of parthanatos related molecular subgroup and prognostic model development in stomach adenocarcinoma.,2025,10.1371/journal.pone.0332988,https://pubmed.ncbi.nlm.nih.gov/41004487/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,42900236,CCKBR signalling controls human definitive endoderm specification and pancreatic lineage differentiation.,2026,10.1007/s00125-026-06905-0,https://pubmed.ncbi.nlm.nih.gov/42900236/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,41635853,Oral tolerogenic vaccine combined with gastrin restores immune tolerance and beta-cell function in NOD mice with Type 1 diabetes.,2025,10.3389/fimmu.2025.1740385,https://pubmed.ncbi.nlm.nih.gov/41635853/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,42724882,The prognostic value and molecular mechanisms of &lt;i&gt;Porphyromonas gingivalis&lt;/i&gt; infection-associated differentially expressed genes in oral squamous cell carcinoma.,2026,10.21037/tcr-2026-0747,https://pubmed.ncbi.nlm.nih.gov/42724882/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,42251258,Plasma protein signatures altered before and after tuberculosis diagnosis in a population-based cohort.,2026,10.1186/s12014-026-09602-7,https://pubmed.ncbi.nlm.nih.gov/42251258/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,40900699,Next generation sequencing as a panacea for antibiotic susceptibility testing: yea or nay?,2025,10.3389/fpubh.2025.1650925,https://pubmed.ncbi.nlm.nih.gov/40900699/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,41719850,GAST-NET: A multi-modal and multi-task deep learning framework for preoperative prediction of perineural invasion and prognostic risk in gastric cancer.,2026,10.1016/j.ijmedinf.2026.106348,https://pubmed.ncbi.nlm.nih.gov/41719850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,40805163,Bioinformatics Screening of Tumor-Derived Neuropeptides Mediating Neuroimmune Axis of Head and Neck Cancer.,2025,10.3390/cancers17152464,https://pubmed.ncbi.nlm.nih.gov/40805163/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,40753405,hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway.,2025,10.1186/s13287-025-04328-z,https://pubmed.ncbi.nlm.nih.gov/40753405/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,41511880,Gastrin for the treatment of acute graft-versus-host disease of the stomach.,2026,10.1182/blood.2025031080,https://pubmed.ncbi.nlm.nih.gov/41511880/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,42380428,OsWRKY11 Regulates Rice Leaf Angle Via Transcriptional Activation of OsGSR1.,2026,10.1186/s12284-026-00929-1,https://pubmed.ncbi.nlm.nih.gov/42380428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,40234147,Retrospective 3D analysis of changes in the masseter muscles and soft tissues following orthognathic surgery for patients with maxillomandibular asymmetry: 12-month CBCT study.,2025,10.1016/j.ijom.2025.04.002,https://pubmed.ncbi.nlm.nih.gov/40234147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,39593834,The Representative Points of Generalized Alpha Skew-t Distribution and Applications.,2024,10.3390/e26110889,https://pubmed.ncbi.nlm.nih.gov/39593834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,40281224,Epigenetic markers of disease risk and psychotherapy response in anxiety disorders - a longitudinal analysis of the DNA methylome.,2025,10.1038/s41380-025-03038-5,https://pubmed.ncbi.nlm.nih.gov/40281224/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,42017488,Integrated network toxicology and multi-omics analysis reveals Benzo(a)pyrene-driven molecular networks and prognostic biomarkers in colon cancer.,2026,10.1080/09603123.2026.2660833,https://pubmed.ncbi.nlm.nih.gov/42017488/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,39607028,Higher AMPK activation in mouse oxidative compared with glycolytic muscle does not correlate with LKB1 or CaMKKβ expression.,2025,10.1152/ajpendo.00261.2024,https://pubmed.ncbi.nlm.nih.gov/39607028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,38732462,Genome-Wide Identification of GAST Family Members and Their Potential Roles in Epicotyl Dormancy in Chinese Cork Oak (Quercus variabilis).,2024,10.3390/plants13091247,https://pubmed.ncbi.nlm.nih.gov/38732462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,37606041,Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity.,2023,10.1172/jci.insight.166386,https://pubmed.ncbi.nlm.nih.gov/37606041/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,40753649,Progastrin Promotes Colorectal Cancer Stem Cell-Like Properties via the Receptor PZR.,2025,10.1002/advs.202502136,https://pubmed.ncbi.nlm.nih.gov/40753649/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,38906914,GnRH agonist early follicular challenge test as a predictor of ovarian response in antagonist cycles for fertility preservation.,2024,10.1038/s41598-024-65059-4,https://pubmed.ncbi.nlm.nih.gov/38906914/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,40611840,Gastroesophageal reflux disease over time in endoscopic versus surgical myotomy for treatment of achalasia: Systematic review and meta-analysis.,2025,10.1055/a-2621-5421,https://pubmed.ncbi.nlm.nih.gov/40611840/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,41978184,Effects of Menthol Mouth Rinsing on Performance and Surface EMG Activity During Heat-Stressed Cycling.,2026,10.3390/nu18071134,https://pubmed.ncbi.nlm.nih.gov/41978184/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,40659880,Unrecognized mutations in DPYD* 2 A wild-type rectal cancer patients receiving postoperative 5-FU-based chemotherapy - do they have a clinical impact?,2025,10.1007/s00280-025-04787-4,https://pubmed.ncbi.nlm.nih.gov/40659880/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,41042779,Vehicle rescue path planning for urban traffic waterlogging disaster based on GAST model.,2025,10.1371/journal.pone.0332989,https://pubmed.ncbi.nlm.nih.gov/41042779/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,36588538,Identification of an Immune-Related Gene Signature Associated with Prognosis and Tumor Microenvironment in Esophageal Cancer.,2022,10.1155/2022/7413535,https://pubmed.ncbi.nlm.nih.gov/36588538/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,38168759,RNA sequencing and proteomic profiling reveal alterations by MPTP in chronic stomach mucosal injury in tree shrew Chinese (Tupaia belangeri chinensis).,2024,10.1038/s41598-023-50820-y,https://pubmed.ncbi.nlm.nih.gov/38168759/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,37777726,A combined clinical and specific genes' model to predict live birth for in vitro fertilization and embryo transfer patients.,2023,10.1186/s12884-023-05988-6,https://pubmed.ncbi.nlm.nih.gov/37777726/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,37837103,Assessment of Number of Critical Satellites for Ground-Based Augmentation System Continuity Allocation to Support Category II/III Precision Approaches.,2023,10.3390/s23198273,https://pubmed.ncbi.nlm.nih.gov/37837103/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,39282247,Seven Immune-Related Genes' Prognostic Value and Correlation with Treatment Outcome in Head and Neck Squamous Cell Carcinoma.,2023,10.1155/2023/8533476,https://pubmed.ncbi.nlm.nih.gov/39282247/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GAST,ENSG00000184502,Unsafe,36567723,Development and validation of a predictive model for immune-related genes in patients with tongue squamous cell carcinoma.,2022,10.1515/biol-2022-0469,https://pubmed.ncbi.nlm.nih.gov/36567723/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,41941629,AI-derived therapeutic development of a serotonin receptor-targeting drug for the treatment of opioid use disorder.,2026,10.1073/pnas.2516807123,https://pubmed.ncbi.nlm.nih.gov/41941629/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,42901929,Spatial partitioning of NSD2 defines H3K36me2 as an active mark for repetitive sequence activation.,2026,10.1038/s41467-026-77898-y,https://pubmed.ncbi.nlm.nih.gov/42901929/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,42123550,Operon™ Platform-Enabled for Cardiometabolic Biomarker Screening and Precision Treatment Strategies: A Type 2 Diabetes-Centered Review with Cardiovascular Extension.,2026,10.3390/ijms27093969,https://pubmed.ncbi.nlm.nih.gov/42123550/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,42092767,Temperature-dependent dynamics of DNA methylation and plasmid copy number in Yersinia pestis.,2026,10.1186/s12864-026-12915-4,https://pubmed.ncbi.nlm.nih.gov/42092767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,41261854,Distribution of DNA gyrase cleavage sites across the Streptococcus pneumoniae genome: relation to transcription and methylation at GATC sites.,2025,10.1093/nar/gkaf1183,https://pubmed.ncbi.nlm.nih.gov/41261854/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,40563272,Ganoapplanilactone C from &lt;i&gt;Ganoderma applanatum&lt;/i&gt; Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK/mTOR-Mediated Lipid Regulation in Zebrafish.,2025,10.3390/antiox14060637,https://pubmed.ncbi.nlm.nih.gov/40563272/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,42241453,Phenotypic heterogeneity optimizes trade-offs during adaptive deployment of the type VI secretion system.,2026,10.1371/journal.pbio.3003838,https://pubmed.ncbi.nlm.nih.gov/42241453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,40295218,"Adaptive Evolution of GatC, a Component of the Galactitol Phosphotransferase System, for Glucose Transport in &lt;i&gt;Escherichia coli&lt;/i&gt;.",2025,10.4014/jmb.2502.02021,https://pubmed.ncbi.nlm.nih.gov/40295218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,41913962,How Genomic and Structural Context Could Shape JAK-STAT Variant Pathogenicity.,2026,10.1017/thg.2026.10054,https://pubmed.ncbi.nlm.nih.gov/41913962/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,41197728,Tetramerization of the DNA mismatch repair protein MutS enhances daughter strand incision preferentially in the vicinity of replication errors.,2025,10.1016/j.jbc.2025.110881,https://pubmed.ncbi.nlm.nih.gov/41197728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,40698946,Epigenetic control of the ferric uptake regulator (Fur) and fumarate nitrate reductase (FNR) master regulatory proteins contributes to &lt;i&gt;Haemophilus influenzae&lt;/i&gt; survival during lung infection.,2025,10.1128/mbio.01355-25,https://pubmed.ncbi.nlm.nih.gov/40698946/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,40177680,Decoding the genome and epigenome of avian &lt;i&gt;Escherichia coli&lt;/i&gt; strains by R10.4.1 nanopore sequencing.,2025,10.3389/fvets.2025.1541964,https://pubmed.ncbi.nlm.nih.gov/40177680/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,40985779,Dam-dependent epigenetic memory regulates prophage reintegration in Salmonella.,2025,10.1093/nar/gkaf951,https://pubmed.ncbi.nlm.nih.gov/40985779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,40985635,DNA adenine methylation influences gene expression and biofilm formation in &lt;i&gt;Streptococcus mutans&lt;/i&gt;.,2025,10.1128/aem.01094-25,https://pubmed.ncbi.nlm.nih.gov/40985635/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,41005475,AlphaFold3-guided optimization of a photoactivatable endonuclease for top-down genome engineering.,2025,10.1016/j.jbc.2025.110762,https://pubmed.ncbi.nlm.nih.gov/41005475/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,36362281,Light Dependent Changes in Adenylate Methylation of the Promoter of the Mitochondrial Citrate Synthase Gene in Maize (Zea mays L.) Leaves.,2022,10.3390/ijms232113495,https://pubmed.ncbi.nlm.nih.gov/36362281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,39660654,Genome-wide mapping of spontaneous DNA replication error-hotspots using mismatch repair proteins in rapidly proliferating Escherichia coli.,2025,10.1093/nar/gkae1196,https://pubmed.ncbi.nlm.nih.gov/39660654/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,39624001,Decoding Adenine DNA Methylation Effects in Streptococcus Mutans: Insights Into Self-DNA Protection and Autoaggregation.,2025,10.1111/omi.12489,https://pubmed.ncbi.nlm.nih.gov/39624001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,40248715,Development of a multi-epitope vaccine from outer membrane proteins and identification of novel drug targets against &lt;i&gt;Francisella tularensis&lt;/i&gt;: an &lt;i&gt;In Silico&lt;/i&gt; approach.,2025,10.3389/fimmu.2025.1479862,https://pubmed.ncbi.nlm.nih.gov/40248715/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,38112443,Distinct epigenetic signatures of classical and hypervirulent &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt;.,2024,10.1128/msphere.00464-23,https://pubmed.ncbi.nlm.nih.gov/38112443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,42710346,XenoSoM: A deep learning framework for site of metabolism prediction of xenobiotics.,2026,10.1016/j.ejmech.2026.119312,https://pubmed.ncbi.nlm.nih.gov/42710346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,41538317,Machine learning reveals sequence and methylation determinants of SaCas9-PAM interactions in bacteria.,2026,10.1093/nar/gkaf1520,https://pubmed.ncbi.nlm.nih.gov/41538317/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,36985272,Investigation of a Listeria monocytogenes Chromosomal Immigration Control Region Reveals Diverse Restriction Modification Systems with Complete Sequence Type Conservation.,2023,10.3390/microorganisms11030699,https://pubmed.ncbi.nlm.nih.gov/36985272/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,37780356,Single-Nucleotide Resolution Mapping of N6-Methyladenine in Genomic DNA.,2023,10.1021/acscentsci.3c00481,https://pubmed.ncbi.nlm.nih.gov/37780356/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,37436062,Hemin availability induces coordinated DNA methylation and gene expression changes in Porphyromonas gingivalis.,2023,10.1128/msystems.01193-22,https://pubmed.ncbi.nlm.nih.gov/37436062/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,29857077,The Role of Vitamin D Receptor Polymorphisms in Predicting the Response to Therapy for Nonmuscle Invasive Bladder Carcinoma.,2018,10.1016/j.juro.2018.05.120,https://pubmed.ncbi.nlm.nih.gov/29857077/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,34413503,Identification of Tse8 as a Type VI secretion system toxin from Pseudomonas aeruginosa that targets the bacterial transamidosome to inhibit protein synthesis in prey cells.,2021,10.1038/s41564-021-00950-8,https://pubmed.ncbi.nlm.nih.gov/34413503/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,36802234,Synergistic Effect of SOS Response and GATC Methylome Suppression on Antibiotic Stress Survival in Escherichia coli.,2023,10.1128/aac.01392-22,https://pubmed.ncbi.nlm.nih.gov/36802234/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,26998690,A role for the bacterial GATC methylome in antibiotic stress survival.,2016,10.1038/ng.3530,https://pubmed.ncbi.nlm.nih.gov/26998690/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,27174933,Dual daughter strand incision is processive and increases the efficiency of DNA mismatch repair.,2016,10.1093/nar/gkw411,https://pubmed.ncbi.nlm.nih.gov/27174933/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GATC,ENSG00000257218,Unsafe,31216025,"Regulation of bistability in the std fimbrial operon of Salmonella enterica by DNA adenine methylation and transcription factors HdfR, StdE and StdF.",2019,10.1093/nar/gkz530,https://pubmed.ncbi.nlm.nih.gov/31216025/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,40519143,De Novo Variant in GBX1 Gene Associated With Developmental Delay and Focal Epilepsy.,2025,10.1002/mgg3.70114,https://pubmed.ncbi.nlm.nih.gov/40519143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,41844159,GABAergic Gbx1 neurons of the superficial dorsal horn are critical elements of a spinal circuit for stress-induced analgesia.,2026,10.1016/j.neuron.2026.01.033,https://pubmed.ncbi.nlm.nih.gov/41844159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,41620616,MER57E3 transposable elements regulate gene expression in a human cell model of neural development.,2026,10.1186/s13059-026-03946-x,https://pubmed.ncbi.nlm.nih.gov/41620616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,38570112,A role for Retinoblastoma 1 in hindbrain morphogenesis by regulating GBX family.,2024,10.1016/j.jgg.2024.03.008,https://pubmed.ncbi.nlm.nih.gov/38570112/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,40062616,Inferring gene regulatory networks from time-series scRNA-seq data via GRANGER causal recurrent autoencoders.,2025,10.1093/bib/bbaf089,https://pubmed.ncbi.nlm.nih.gov/40062616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,32244588,Gbx1 and Gbx2 Are Essential for Normal Patterning and Development of Interneurons and Motor Neurons in the Embryonic Spinal Cord.,2020,10.3390/jdb8020009,https://pubmed.ncbi.nlm.nih.gov/32244588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,27396829,Dynamic Local Polymorphisms in the Gbx1 Homeodomain Induced by DNA Binding.,2016,10.1016/j.str.2016.05.013,https://pubmed.ncbi.nlm.nih.gov/27396829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,23418536,Characterization of the Gbx1-/- mouse mutant: a requirement for Gbx1 in normal locomotion and sensorimotor circuit development.,2013,10.1371/journal.pone.0056214,https://pubmed.ncbi.nlm.nih.gov/23418536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,24010020,The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord.,2013,10.7717/peerj.142,https://pubmed.ncbi.nlm.nih.gov/24010020/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,24318815,Real-time PCR quantification of gene expression in embryonic mouse tissue.,2014,10.1007/978-1-60327-292-6_6,https://pubmed.ncbi.nlm.nih.gov/24318815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,22826214,Effects of retinoic acid and Gbx1 on feather-bud formation and epidermal transdifferentiation in chick embryonic cultured dorsal skin.,2012,10.1002/dvdy.23834,https://pubmed.ncbi.nlm.nih.gov/22826214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,29289755,The role of gastrulation brain homeobox 2 (gbx2) in the development of the ventral telencephalon in zebrafish embryos.,2018,10.1016/j.diff.2017.12.005,https://pubmed.ncbi.nlm.nih.gov/29289755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,19341460,Zebrafish gbx1 refines the midbrain-hindbrain boundary border and mediates the Wnt8 posteriorization signal.,2009,10.1186/1749-8104-4-12,https://pubmed.ncbi.nlm.nih.gov/19341460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,24183937,Cerebellar development in the absence of Gbx function in zebrafish.,2014,10.1016/j.ydbio.2013.10.026,https://pubmed.ncbi.nlm.nih.gov/24183937/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,29945667,Analysis of novel caudal hindbrain genes reveals different regulatory logic for gene expression in rhombomere 4 versus 5/6 in embryonic zebrafish.,2018,10.1186/s13064-018-0112-y,https://pubmed.ncbi.nlm.nih.gov/29945667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,22252490,"Tgm2/Gh, Gbx1 and TGF-beta are involved in retinoic acid-induced transdifferentiation from epidermis to mucosal epithelium.",2011,10.1387/ijdb.113326ao,https://pubmed.ncbi.nlm.nih.gov/22252490/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,16193514,The homeodomain transcription factor Gbx1 identifies a subpopulation of late-born GABAergic interneurons in the developing dorsal spinal cord.,2005,10.1002/dvdy.20568,https://pubmed.ncbi.nlm.nih.gov/16193514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,12799077,Cloning and embryonic expression analysis of the mouse Gbx1 gene.,2003,10.1016/s1567-133x(03)00041-3,https://pubmed.ncbi.nlm.nih.gov/12799077/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,11801365,The homeobox genes Lhx7 and Gbx1 are expressed in the basal forebrain cholinergic system.,2002,10.1016/s0306-4522(01)00466-3,https://pubmed.ncbi.nlm.nih.gov/11801365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,16597639,cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles.,2006,10.1093/molehr/gal035,https://pubmed.ncbi.nlm.nih.gov/16597639/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GBX1,ENSG00000164900,Unsafe,42464188,Glioblastoma immune-related gene landscape and its prognostic significance identified with integrative multiomics.,2026,10.1186/s12885-026-16507-z,https://pubmed.ncbi.nlm.nih.gov/42464188/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,42617052,Two Paralogues as They Like It: Conserved and Divergent Evolution of Vertebrate Gcm Genes.,2026,10.1111/ede.70057,https://pubmed.ncbi.nlm.nih.gov/42617052/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,42217332,Characterizing glial cells missing transcription factor 1 (GCM1)'s role in regulating placental gene expression.,2026,10.1016/j.placenta.2026.05.031,https://pubmed.ncbi.nlm.nih.gov/42217332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,42438639,The Gastro-Circadian Metabolic Axis: A Comprehensive Framework for Chronotherapy in Gastroenterology.,2026,10.7759/cureus.110724,https://pubmed.ncbi.nlm.nih.gov/42438639/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,41217685,Gcm1 Orchestrates Lef1 Expression in Folate Deficiency-Induced Neural Tube Defects.,2025,10.1007/s12035-025-05346-x,https://pubmed.ncbi.nlm.nih.gov/41217685/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,41323267,Glial cells missing 1 triggers gliosis and angiogenesis after neonatal brain injury.,2025,10.1016/j.isci.2025.113860,https://pubmed.ncbi.nlm.nih.gov/41323267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,42745947,The placental maturation inflection point: an integrative biological framework for understanding early-onset versus late-onset preeclampsia.,2026,10.3389/fendo.2026.1899767,https://pubmed.ncbi.nlm.nih.gov/42745947/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,42168247,Placental dysfunction reflects endocrine impairment and trophoblast alterations in polycystic ovarian syndrome.,2026,10.1038/s41598-026-51085-x,https://pubmed.ncbi.nlm.nih.gov/42168247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,42692008,Insulin receptor substrate 2 regulates placental syncytiotrophoblast differentiation at the maternal-fetal interface.,2026,10.1016/j.stemcr.2026.103061,https://pubmed.ncbi.nlm.nih.gov/42692008/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,41537828,Evolution and expression of glial cells missing (GCM1 and GCM2) in monotremes suggest an ancient role in reproduction.,2025,10.1098/rsob.250083,https://pubmed.ncbi.nlm.nih.gov/41537828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,40280139,Hypoxia and loss of GCM1 expression prevent differentiation and contact inhibition in human trophoblast stem cells.,2025,10.1016/j.stemcr.2025.102481,https://pubmed.ncbi.nlm.nih.gov/40280139/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,41117589,Functional Interaction of GCM1 and LINC01118 Regulates Syncytiotrophoblast Differentiation.,2025,10.1096/fj.202501013rr,https://pubmed.ncbi.nlm.nih.gov/41117589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,41811437,Directed differentiation of bovine trophoblast stem cells: A useful in vitro model for placenta development.,2026,10.1073/pnas.2600783123,https://pubmed.ncbi.nlm.nih.gov/41811437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,41123510,Activity of the SWI/SNF complex is indispensable for syncytiotrophoblast formation.,2025,10.1242/dev.204770,https://pubmed.ncbi.nlm.nih.gov/41123510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,42374437,Single-cell profiling of gastric cancer ascites reveals an epithelial-immune dual phenotype signature predictive for anti-PD-1 immunotherapy responses.,2026,10.1186/s12916-026-05017-1,https://pubmed.ncbi.nlm.nih.gov/42374437/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,40523492,Chitosan-based enzyme-immobilized nanocomposite cryogels with controlled biodegradation profile.,2025,10.1016/j.ijbiomac.2025.145275,https://pubmed.ncbi.nlm.nih.gov/40523492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,40295383,Rosiglitazone-Mediated Activation of PPARγ Induces PlGF Expression in Trophoblast Cells.,2025,10.1007/s43032-025-01868-w,https://pubmed.ncbi.nlm.nih.gov/40295383/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,40300673,Cadmium exposure causes trophoblast abnormal syncytization and endocrine dysfunction in preeclampsia.,2025,10.1016/j.reprotox.2025.108934,https://pubmed.ncbi.nlm.nih.gov/40300673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,42391000,Rotational trophoblast organoids reveal biomechanical regulation of trophoblast differentiation.,2026,10.1016/j.celrep.2026.117637,https://pubmed.ncbi.nlm.nih.gov/42391000/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,41278212,Reduced Wiskott-Aldrich syndrome protein expression in preeclampsia placenta impairs trophoblast syncytialization by modulating syncytin-2 via FAK/β-catenin pathway.,2025,10.3389/fcell.2025.1678878,https://pubmed.ncbi.nlm.nih.gov/41278212/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,40733804,Molecular insights into the mechanism between the structural and mechanical properties of glycol chitosan methacrylate hydrogels.,2025,10.1016/j.carbpol.2025.123872,https://pubmed.ncbi.nlm.nih.gov/40733804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,33664222,Aberrant Gcm1 expression mediates Wnt/β-catenin pathway activation in folate deficiency involved in neural tube defects.,2021,10.1038/s41419-020-03313-z,https://pubmed.ncbi.nlm.nih.gov/33664222/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,40458123,Nodal and cripto-1: distinct functions regulate trophoblast specification in mouse pregnancy.,2025,10.3389/fcell.2025.1608976,https://pubmed.ncbi.nlm.nih.gov/40458123/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,38534330,Cannabidiol Disrupts Mitochondrial Respiration and Metabolism and Dysregulates Trophoblast Cell Differentiation.,2024,10.3390/cells13060486,https://pubmed.ncbi.nlm.nih.gov/38534330/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,38085778,CRISPR screening in human trophoblast stem cells reveals both shared and distinct aspects of human and mouse placental development.,2023,10.1073/pnas.2311372120,https://pubmed.ncbi.nlm.nih.gov/38085778/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,29755409,Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter.,2018,10.3389/fendo.2018.00195,https://pubmed.ncbi.nlm.nih.gov/29755409/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,26899996,GATA3 inhibits GCM1 activity and trophoblast cell invasion.,2016,10.1038/srep21630,https://pubmed.ncbi.nlm.nih.gov/26899996/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,36241699,Naïve pluripotent-like characteristics of non-tumorigenic Muse cells isolated from human amniotic membrane.,2022,10.1038/s41598-022-22282-1,https://pubmed.ncbi.nlm.nih.gov/36241699/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,31278978,Effects of Bisphenol A on endogenous retroviral envelopes expression and trophoblast fusion in BeWo cells.,2019,10.1016/j.reprotox.2019.07.001,https://pubmed.ncbi.nlm.nih.gov/31278978/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,34238364,Transcriptomic analysis of equine chorioallantois reveals immune networks and molecular mechanisms involved in nocardioform placentitis.,2021,10.1186/s13567-021-00972-4,https://pubmed.ncbi.nlm.nih.gov/34238364/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,32319609,In vitro fertilization and embryo transfer alter human placental function through trophoblasts in early pregnancy.,2020,10.3892/mmr.2020.10971,https://pubmed.ncbi.nlm.nih.gov/32319609/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,23300953,DREAM mediated regulation of GCM1 in the human placental trophoblast.,2013,10.1371/journal.pone.0051837,https://pubmed.ncbi.nlm.nih.gov/23300953/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,32092105,Reactive oxygen species from mitochondria impacts trophoblast fusion and the production of endocrine hormones by syncytiotrophoblasts.,2020,10.1371/journal.pone.0229332,https://pubmed.ncbi.nlm.nih.gov/32092105/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,22109522,Identification of a link between Wnt/β-catenin signalling and the cell fusion             pathway.,2011,10.1038/ncomms1551,https://pubmed.ncbi.nlm.nih.gov/22109522/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,22238282,The molecular role of connexin 43 in human trophoblast cell fusion.,2012,10.1095/biolreprod.111.096925,https://pubmed.ncbi.nlm.nih.gov/22238282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,27917469,Association of dysfunctional synapse defective 1 (SYDE1) with restricted fetal growth - SYDE1 regulates placental cell migration and invasion.,2017,10.1002/path.4835,https://pubmed.ncbi.nlm.nih.gov/27917469/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GCM1,ENSG00000137270,Unsafe,10542267,A GCM motif protein is involved in placenta-specific expression of human aromatase gene.,1999,10.1074/jbc.274.45.32279,https://pubmed.ncbi.nlm.nih.gov/10542267/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDAP2,ENSG00000196505,Unsafe,42633453,Progressive Slurred Speech as an Atypical Presentation of GDAP2-Related Spinocerebellar Ataxia: A Case Report.,2026,10.7759/cureus.113246,https://pubmed.ncbi.nlm.nih.gov/42633453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDAP2,ENSG00000196505,Unsafe,40469082,Autosomal Recessive Cerebellar Ataxia-27 Caused by a Novel Loss-of-Function Variant of Ganglioside-Induced Differentiation Associated Protein 2 in a Spanish Family.,2025,10.1212/nxg.0000000000200268,https://pubmed.ncbi.nlm.nih.gov/40469082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDAP2,ENSG00000196505,Unsafe,40205793,"Dimm targets GDAP2 to regulate larval development in the silkworm, Bombyx mori.",2026,10.1111/1744-7917.70032,https://pubmed.ncbi.nlm.nih.gov/40205793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDAP2,ENSG00000196505,Unsafe,40332832,"CRISPR/Cas9-Mediated Knockout of &lt;i&gt;BmGDAP2&lt;/i&gt; in the Silkworm, &lt;i&gt;Bombyx mori&lt;/i&gt;: Extended Lifespan and Altered Gene Expression Impacting Developmental Pathways.",2025,10.3390/insects16040354,https://pubmed.ncbi.nlm.nih.gov/40332832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDAP2,ENSG00000196505,Unsafe,41755704,Matching heterogeneous cohorts by projected principal components reveals two novel Alzheimer's disease-associated genes in the Hispanic population.,2026,10.1002/alz.71189,https://pubmed.ncbi.nlm.nih.gov/41755704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDAP2,ENSG00000196505,Unsafe,37070050,Isolated Dystonia as an Initial Presentation of GDAP2-Related Disorder.,2023,10.1002/mdc3.13682,https://pubmed.ncbi.nlm.nih.gov/37070050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDAP2,ENSG00000196505,Unsafe,38587696,Genetic aspects of ataxias in a cohort of Turkish patients.,2024,10.1007/s10072-024-07484-x,https://pubmed.ncbi.nlm.nih.gov/38587696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDAP2,ENSG00000196505,Unsafe,35158016,GDAP2 Overexpression Affects the Development of Neurons and Dysregulates Neuronal Excitatory Synaptic Transmission.,2022,10.1016/j.neuroscience.2022.02.005,https://pubmed.ncbi.nlm.nih.gov/35158016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDAP2,ENSG00000196505,Unsafe,36555072,Comparative Silk Transcriptomics Illuminates Distinctive Impact of Artificial Selection in Silkworm Modern Breeding.,2022,10.3390/insects13121163,https://pubmed.ncbi.nlm.nih.gov/36555072/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDAP2,ENSG00000196505,Unsafe,32428220,A homozygous GDAP2 loss-of-function variant in a patient with adult-onset cerebellar ataxia.,2020,10.1093/brain/awaa120,https://pubmed.ncbi.nlm.nih.gov/32428220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDAP2,ENSG00000196505,Unsafe,30084953,GDAP2 mutations implicate susceptibility to cellular stress in a new form of cerebellar ataxia.,2018,10.1093/brain/awy198,https://pubmed.ncbi.nlm.nih.gov/30084953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDAP2,ENSG00000196505,Unsafe,32428197,Reply: A homozygous GDAP2 loss-of-function variant in a patient with adult-onset cerebellar ataxia; and Novel GDAP2 pathogenic variants cause autosomal recessive spinocerebellar ataxia-27 (SCAR27) in a Chinese family.,2020,10.1093/brain/awaa122,https://pubmed.ncbi.nlm.nih.gov/32428197/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDAP2,ENSG00000196505,Unsafe,32658981,Erratum to: Reply: Novel GDAP2 pathogenic variants cause autosomal recessive spinocerebellar ataxia-27 (SCAR27) in a Chinese family.,2020,10.1093/brain/awaa191,https://pubmed.ncbi.nlm.nih.gov/32658981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDAP2,ENSG00000196505,Unsafe,32437512,Novel GDAP2 pathogenic variants cause autosomal recessive spinocerebellar ataxia-27 (SCAR27) in a Chinese family.,2020,10.1093/brain/awaa121,https://pubmed.ncbi.nlm.nih.gov/32437512/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDAP2,ENSG00000196505,Unsafe,33636189,Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors.,2021,10.1016/j.pbiomolbio.2021.02.002,https://pubmed.ncbi.nlm.nih.gov/33636189/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,42893735,"Aerobic exercise ameliorates cardiac function in HFpEF mice by suppressing ALCAT1, neuroinflammation and oxidative stress in the paraventricular nucleus and nucleus tractus solitarius.",2026,10.1016/j.bbi.2026.107078,https://pubmed.ncbi.nlm.nih.gov/42893735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,42494496,GDF5 modulation of MuSC pool as a potential therapeutic benefit for DMD.,2026,10.1016/j.omtn.2026.103005,https://pubmed.ncbi.nlm.nih.gov/42494496/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,42395953,Research on the Improvement of Oxidative Stress Regulation in Periodontal Ligament Stem Cells and the Promotion of Periodontal Bone Tissue Regeneration by GDF5/ROS-Responsive Degradable Hydrogel.,2026,10.1021/acsomega.5c13610,https://pubmed.ncbi.nlm.nih.gov/42395953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,42834521,GDF5 promotes proliferation and inhibits apoptosis of Hu sheep ovarian granulosa cells via the NGF pathway.,2026,10.1093/jas/skag319,https://pubmed.ncbi.nlm.nih.gov/42834521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,41981216,The Versatile Role of GDF5 in Chondrogenic Progenitor Cell-mediated Cartilage Regeneration via a Hyaluronic Acid-fibrin IPN Hydrogel Platform.,2026,10.1007/s11095-026-04079-3,https://pubmed.ncbi.nlm.nih.gov/41981216/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,41701540,GDF5 Exacerbates Tubulointerstitial Injury by Inducing Partial Epithelial-Mesenchymal Transition of Tubular Epithelial Cells in Diabetic Kidney Disease.,2026,10.2337/db25-0599,https://pubmed.ncbi.nlm.nih.gov/41701540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,42106819,Tilorone suppresses TGF-β-driven fibroblast activation and restores BMP-Smad1/5/8 signaling: implications for laryngotracheal fibrosis.,2026,10.1186/s12967-026-08188-w,https://pubmed.ncbi.nlm.nih.gov/42106819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,41751511,Exploratory Analysis of Candidate Gene Variants in Developmental Dysplasia of the Hip: Evidence for the Role of GDF5 rs143384.,2026,10.3390/genes17020129,https://pubmed.ncbi.nlm.nih.gov/41751511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,42248342,Signaling and transcriptional networks governing late synovial joint development.,2026,10.1016/j.ydbio.2026.05.010,https://pubmed.ncbi.nlm.nih.gov/42248342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,41751596,"The Role of &lt;i&gt;COL1A1&lt;/i&gt;, &lt;i&gt;COL5A1&lt;/i&gt;, &lt;i&gt;ACTN3&lt;/i&gt;, &lt;i&gt;MMP3&lt;/i&gt;, and &lt;i&gt;GDF5&lt;/i&gt; Gene Variants in Common Sports Injuries: Systematic Review of ACL Rupture, Achilles Tendinopathy, and Stress Fractures.",2026,10.3390/genes17020212,https://pubmed.ncbi.nlm.nih.gov/41751596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,41465193,The &lt;i&gt;GDF5&lt;/i&gt; rs143384 Polymorphism Is Associated with the Severity of Knee Osteoarthritis and Shorter Stature in Female Brazilian Patients: A Cross-Sectional Study.,2025,10.3390/genes16121520,https://pubmed.ncbi.nlm.nih.gov/41465193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,41135529,"The roles of TGF-β, Wnt, and MAPK signaling pathways in joint lineage specification in vitro and ex vivo.",2025,10.1016/j.stemcr.2025.102685,https://pubmed.ncbi.nlm.nih.gov/41135529/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,42470017,Exploring the cognitive effects of arthritis: A Mendelian randomization study and cross-sectional analysis of NHANES data.,2026,10.1097/md.0000000000049805,https://pubmed.ncbi.nlm.nih.gov/42470017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,41693133,Exploring Injectable Scaffolded Spheroids for Nucleus Pulposus Therapy in Degenerated Intervertebral Discs.,2026,10.1021/acsami.5c24306,https://pubmed.ncbi.nlm.nih.gov/41693133/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,40507824,&lt;i&gt;GDF5&lt;/i&gt; rs143384 Polymorphism Associated with Developmental Dysplasia of the Hip in Brazilian Patients: A Case-Control Study.,2025,10.3390/ijms26115012,https://pubmed.ncbi.nlm.nih.gov/40507824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,40356240,Complex Regulatory Interactions at GDF5 Shape Joint Morphology and Osteoarthritis Disease Risk.,2025,10.1002/art.43231,https://pubmed.ncbi.nlm.nih.gov/40356240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,42520269,Bowman's glands act as facultative stem cells following olfactory epithelial lesion.,2026,10.1093/chemse/bjag023,https://pubmed.ncbi.nlm.nih.gov/42520269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,41133505,Molecular Pathogenesis of Joint Hypermobility: The Role of Intergenic Interactions.,2025,10.3390/medsci13040223,https://pubmed.ncbi.nlm.nih.gov/41133505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,40301343,PDGFRα signaling regulates cartilage and fibrous tissue differentiation during synovial joint development.,2025,10.1038/s41467-025-59207-1,https://pubmed.ncbi.nlm.nih.gov/40301343/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,41530564,Multi-omics and molecular testing: A new insight into the genetic mechanisms of sarcopenia and arthritis.,2026,10.1007/s10238-025-01985-5,https://pubmed.ncbi.nlm.nih.gov/41530564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,40510624,Growth differentiation factor 5 improves meniscal healing in a pilot study on rats.,2025,10.1002/jeo2.70309,https://pubmed.ncbi.nlm.nih.gov/40510624/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,42466588,Genome-Wide Resequencing Reveals Genetic Diversity and Selection Signatures in Two Indigenous Goat Populations From Xizang.,2026,10.1002/age.70162,https://pubmed.ncbi.nlm.nih.gov/42466588/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,38836497,The role of GDF5 in regulating enthesopathy development in the Hyp mouse model of XLH.,2024,10.1093/jbmr/zjae086,https://pubmed.ncbi.nlm.nih.gov/38836497/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,39847883,Associations and potential epigenetic changes between air pollution and osteoarthritis risk and survival: Insights from a prospective cohort study.,2025,10.1016/j.ecoenv.2025.117770,https://pubmed.ncbi.nlm.nih.gov/39847883/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,40153751,Comprehensive analysis of GDFs as therapeutic targets and prognosis biomarkers in gastric cancer.,2025,10.1097/md.0000000000041976,https://pubmed.ncbi.nlm.nih.gov/40153751/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,39953483,"A cross-sectional study on the assessment of COLL11A1, VEGF, and GDF5 gene polymorphisms in Turkish patients with primary knee osteoarthritis.",2025,10.1186/s12891-025-08396-3,https://pubmed.ncbi.nlm.nih.gov/39953483/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,39684678,Transcriptomic Analysis Reveals the Potential Mechanism of &lt;i&gt;Cardamine circaeoides&lt;/i&gt; Hook.f. &amp; Thomson in Lowering Serum Uric Acid by Reducing Inflammatory State Through CCR7 Target.,2024,10.3390/ijms252312967,https://pubmed.ncbi.nlm.nih.gov/39684678/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,40430278,Curcumin-Induced Molecular Mechanisms in U-87 MG Glioblastoma Cells: Insights from Global Gene Expression Profiling.,2025,10.3390/molecules30102108,https://pubmed.ncbi.nlm.nih.gov/40430278/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,41096844,Transcriptomic Analysis of the Effects of Hydroxysafflor Yellow A on hUC-MSC Senescence via the ECM-Receptor Interaction Pathway.,2025,10.3390/ijms26199579,https://pubmed.ncbi.nlm.nih.gov/41096844/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,39248710,Decisive gene strategy on osteoarthritis: a comprehensive whole-literature based approach for conclusive gene targets.,2024,10.18632/aging.206094,https://pubmed.ncbi.nlm.nih.gov/39248710/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,39596594,Transcriptome Sequencing Analysis of Genes Associated with Different Developmental Periods of the Ovarian Follicle in the Duolang Sheep.,2024,10.3390/genes15111394,https://pubmed.ncbi.nlm.nih.gov/39596594/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,39156961,Molecular mechanisms and genetic factors contributing to the developmental dysplasia of the hip.,2024,10.3389/fgene.2024.1413500,https://pubmed.ncbi.nlm.nih.gov/39156961/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,33542911,Systemic Overexpression of GDF5 in Adipocytes but Not Hepatocytes Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver in Mice.,2021,10.1155/2021/8894685,https://pubmed.ncbi.nlm.nih.gov/33542911/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,36618945,Morroniside ameliorates inflammatory skeletal muscle atrophy &lt;i&gt;via&lt;/i&gt; inhibiting canonical and non-canonical NF-κB and regulating protein synthesis/degradation.,2022,10.3389/fphar.2022.1056460,https://pubmed.ncbi.nlm.nih.gov/36618945/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,31660079,3D-bioprinting a genetically inspired cartilage scaffold with GDF5-conjugated BMSC-laden hydrogel and polymer for cartilage repair.,2019,10.7150/thno.38061,https://pubmed.ncbi.nlm.nih.gov/31660079/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,36089590,Single nucleotide polymorphism genes and mitochondrial DNA haplogroups as biomarkers for early prediction of knee osteoarthritis structural progressors: use of supervised machine learning classifiers.,2022,10.1186/s12916-022-02491-1,https://pubmed.ncbi.nlm.nih.gov/36089590/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,32928309,Association between growth differentiation factor 5 rs143383 genetic polymorphism and the risk of knee osteoarthritis among Caucasian but not Asian: a meta-analysis.,2020,10.1186/s13075-020-02306-9,https://pubmed.ncbi.nlm.nih.gov/32928309/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF5,ENSG00000125965,Unsafe,11276205,A CD14-independent LPS receptor cluster.,2001,10.1038/86342,https://pubmed.ncbi.nlm.nih.gov/11276205/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,42313493,Distal enhancer-insulator module of GDF6 is essential for cochlear formation.,2026,10.1172/jci.insight.195462,https://pubmed.ncbi.nlm.nih.gov/42313493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,42521041,A multifunctional injectable hydrogel co-delivering GDF6 and MnO&lt;sub&gt;2&lt;/sub&gt; nanozymes alleviates intervertebral disc degeneration by mitigating oxidative stress and promoting anabolic repair.,2026,10.1016/j.freeradbiomed.2026.07.045,https://pubmed.ncbi.nlm.nih.gov/42521041/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,42363592,Interplay between genomic architecture alterations and GDF6 regulation: A candidate mechanism in Nablus mask-like facial syndrome.,2026,10.1016/j.xhgg.2026.100640,https://pubmed.ncbi.nlm.nih.gov/42363592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,42569572,Unveiling differential gene expression and pathways in clear cell renal cell carcinoma with sarcomatoid transformation.,2026,10.7717/peerj.21552,https://pubmed.ncbi.nlm.nih.gov/42569572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,40699648,Dual-Faced Role of GDF6 in Cancer: Mechanistic Insights into Its Context-Dependent Regulation of Metastasis and Immune Evasion Across Human Malignancies.,2025,10.3390/cimb47040249,https://pubmed.ncbi.nlm.nih.gov/40699648/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,41462947,GDF6 Alleviates Pathological Cardiac Hypertrophy via AMPKα Signaling Pathway.,2025,10.3390/biomedicines13122935,https://pubmed.ncbi.nlm.nih.gov/41462947/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,42528056,Nuclear and Mitochondrial DNA Variants in Chiari Malformation Type 1: Insights from an East Coast Malaysian Cohort.,2026,10.5152/eurasianjmed.2026.251209,https://pubmed.ncbi.nlm.nih.gov/42528056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,41677637,Three-Dimensional Human Liver Micro Organoids and Bone Co-Culture Mimics Alcohol-Induced BMP Dysregulation and Bone Remodeling Defects.,2026,10.3390/cells15030274,https://pubmed.ncbi.nlm.nih.gov/41677637/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,41828918,Transcriptome Analysis of Different Stages in the Early Ovarian Development of the Greater Amberjack (&lt;i&gt;Seriola dumerili&lt;/i&gt;).,2026,10.3390/ani16050709,https://pubmed.ncbi.nlm.nih.gov/41828918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,39788971,The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization.,2025,10.1038/s41467-025-55899-7,https://pubmed.ncbi.nlm.nih.gov/39788971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,41421225,The expression profile of the SYT1 gene in laryngeal cancer and its influences on the biological behavior of laryngeal cancer cells.,2026,10.1016/j.bbrc.2025.153092,https://pubmed.ncbi.nlm.nih.gov/41421225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,41210966,Transcriptomic profiling of endothelial progenitor cells in post-COVID-19 patients: Insights at 3 and 6-month post-infection.,2025,10.1016/j.isci.2025.113731,https://pubmed.ncbi.nlm.nih.gov/41210966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,39474078,The GDF6-FTO axis modulates the innate immune and inflammatory response to human respiratory syncytial virus.,2024,10.1016/j.isci.2024.111038,https://pubmed.ncbi.nlm.nih.gov/39474078/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,41118452,METTL3: A dual regulator of oral tissue regeneration and malignancy with therapeutic implications for stem cell therapy and chemoresistance.,2025,10.1177/00368504251389718,https://pubmed.ncbi.nlm.nih.gov/41118452/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,40965795,Neurological and neuropsychological correlates of Klippel-Feil syndrome.,2025,10.1007/s10072-025-08454-7,https://pubmed.ncbi.nlm.nih.gov/40965795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,42243969,Targeted delivery of TGF-β inhibitor via LHRH-NanoTi reverses the NAT10/ac4C-mediated cisplatin-induced immunosuppressive tumor microenvironment in ovarian cancer.,2026,10.1186/s12951-026-04631-8,https://pubmed.ncbi.nlm.nih.gov/42243969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,42450734,Genome-Wide Characterization of the TGF-β Gene Family in Donkey (&lt;i&gt;Equus asinus&lt;/i&gt;) Reveals Lineage-Specific Gene Duplications and Deleterious Mutations.,2026,10.3390/ani16132028,https://pubmed.ncbi.nlm.nih.gov/42450734/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,38850874,GDF6 in gastric cancer upregulated by helicobacter pylori induces epithelial-mesenchymal translation via the TGF-β/SMAD3 signaling pathway.,2024,10.1016/j.prp.2024.155384,https://pubmed.ncbi.nlm.nih.gov/38850874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,37446238,Bone Morphogenetic Protein 13 Has Protumorigenic Effects on Hepatocellular Carcinoma Cells In Vitro.,2023,10.3390/ijms241311059,https://pubmed.ncbi.nlm.nih.gov/37446238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,40434970,Proliferative arrest induces neuronal differentiation and innate immune responses in normal and Creutzfeldt-Jakob Disease agent (CJ) infected rat septal neurons.,2025,10.1371/journal.pone.0323825,https://pubmed.ncbi.nlm.nih.gov/40434970/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,41550415,Emerging concepts in osteoarthritis and musculoskeletal diseases: Insights from the University of Debrecen Musculoskeletal Symposium 2025.,2026,10.1016/j.ocarto.2025.100728,https://pubmed.ncbi.nlm.nih.gov/41550415/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,41967197,Comparative phenotypic and transcriptomic analysis of equine ovarian follicular aspirates-derived mesenchymal stromal cells and dermal fibroblasts.,2026,10.1016/j.anireprosci.2026.108179,https://pubmed.ncbi.nlm.nih.gov/41967197/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,39440060,Construction and validation of a comprehensive metabolism-associated prognostic model for predicting survival and immunotherapy benefits in ovarian cancer.,2024,10.7150/jca.100796,https://pubmed.ncbi.nlm.nih.gov/39440060/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,38074896,Exosomal miRNA-155-5p from M1-polarized macrophages suppresses angiogenesis by targeting GDF6 to interrupt diabetic wound healing.,2023,10.1016/j.omtn.2023.102074,https://pubmed.ncbi.nlm.nih.gov/38074896/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,38821217,Transforming growth factor-β (TGF-β): A master signal pathway in teleost sex determination.,2024,10.1016/j.ygcen.2024.114561,https://pubmed.ncbi.nlm.nih.gov/38821217/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,35565057,Potential Biomarkers and Drugs for Nanoparticle-Induced Cytotoxicity in the Retina: Based on Regulation of Inflammatory and Apoptotic Genes.,2022,10.3390/ijerph19095664,https://pubmed.ncbi.nlm.nih.gov/35565057/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,33147457,GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth.,2020,10.1016/j.celrep.2020.108332,https://pubmed.ncbi.nlm.nih.gov/33147457/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,32737436,Rare heterozygous GDF6 variants in patients with renal anomalies.,2020,10.1038/s41431-020-0678-9,https://pubmed.ncbi.nlm.nih.gov/32737436/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,27311402,Growth differentiation factor 6 derived from mesenchymal stem/stromal cells reduces age-related functional deterioration in multiple tissues.,2016,10.18632/aging.100982,https://pubmed.ncbi.nlm.nih.gov/27311402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,29202482,Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma.,2018,10.1172/jci92513,https://pubmed.ncbi.nlm.nih.gov/29202482/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,33330428,Non-viral Gene Delivery Methods for Bone and Joints.,2020,10.3389/fbioe.2020.598466,https://pubmed.ncbi.nlm.nih.gov/33330428/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,17010201,Eye and neural defects associated with loss of GDF6.,2006,10.1186/1471-213x-6-43,https://pubmed.ncbi.nlm.nih.gov/17010201/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,23307924,Contribution of growth differentiation factor 6-dependent cell survival to early-onset retinal dystrophies.,2013,10.1093/hmg/dds560,https://pubmed.ncbi.nlm.nih.gov/23307924/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDF6,ENSG00000156466,Unsafe,19521550,BMP13 prevents the effects of annular injury in an ovine model.,2009,10.7150/ijbs.5.388,https://pubmed.ncbi.nlm.nih.gov/19521550/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,42545071,Identification of a Duplication in the RP17 Locus in an Individual With Pathogenic CEP290 Variants: Implications for RP17 Variant Classification.,2026,10.1167/iovs.67.10.1,https://pubmed.ncbi.nlm.nih.gov/42545071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,42270842,Bulk and single-cell transcriptomics reveal prognostic signatures of phosphoinositide metabolism in lung adenocarcinoma.,2026,10.1038/s41598-026-56684-2,https://pubmed.ncbi.nlm.nih.gov/42270842/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,42278330,A Metabolic-Related Gene Signature for Predicting Biochemical Recurrence After Radical Prostatectomy: An Integrative Analysis and Targeted Therapeutic Validation.,2026,10.3390/ijms27114797,https://pubmed.ncbi.nlm.nih.gov/42278330/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,42083781,PHR1 mediates rapid high light responses and acclimation to high photosynthetic activity.,2026,10.1111/tpj.70901,https://pubmed.ncbi.nlm.nih.gov/42083781/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,42256269,Structural variation drives praziquantel response and host adaptation in &lt;i&gt;Schistosoma japonicum&lt;/i&gt;.,2026,10.1016/j.isci.2026.116118,https://pubmed.ncbi.nlm.nih.gov/42256269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,41326985,The non-tandem CCCH zinc finger protein AtC3H26 modulates salt stress response and phosphate starvation response through its ribonuclease activity in Arabidopsis.,2025,10.1186/s12870-025-07857-0,https://pubmed.ncbi.nlm.nih.gov/41326985/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,39882172,Glycerophosphodiester phosphodiesterase 1 mediates G3P accumulation for Eureka lemon resistance to citrus yellow vein clearing virus.,2025,10.1093/hr/uhae287,https://pubmed.ncbi.nlm.nih.gov/39882172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,38945353,Alteration of N6-methyladenosine modification profiles in the neutrophilic RNAs following ischemic stroke.,2024,10.1016/j.neuroscience.2024.06.014,https://pubmed.ncbi.nlm.nih.gov/38945353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,34673020,Development of a selective fluorescence-based enzyme assay for glycerophosphodiesterase family members GDE4 and GDE7.,2021,10.1016/j.jlr.2021.100141,https://pubmed.ncbi.nlm.nih.gov/34673020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,35538151,A viral interferon regulatory factor degrades RNA-binding protein hnRNP Q1 to enhance aerobic glycolysis via recruiting E3 ubiquitin ligase KLHL3 and decaying GDPD1 mRNA.,2022,10.1038/s41418-022-01011-1,https://pubmed.ncbi.nlm.nih.gov/35538151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,39507620,Identification of novel 3D-genome altering and complex structural variants underlying retinitis pigmentosa type 17 through a multistep and high-throughput approach.,2024,10.3389/fgene.2024.1469686,https://pubmed.ncbi.nlm.nih.gov/39507620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,33022222,Structural Variants Create New Topological-Associated Domains and Ectopic Retinal Enhancer-Gene Contact in Dominant Retinitis Pigmentosa.,2020,10.1016/j.ajhg.2020.09.002,https://pubmed.ncbi.nlm.nih.gov/33022222/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,31794025,"Characterization of glycerophosphodiesterase 4-interacting molecules Gαq/11 and Gβ, which mediate cellular lysophospholipase D activity.",2019,10.1042/bcj20190666,https://pubmed.ncbi.nlm.nih.gov/31794025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,38534364,Characterization of Lysophospholipase D Activity in Mammalian Cell Membranes.,2024,10.3390/cells13060520,https://pubmed.ncbi.nlm.nih.gov/38534364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,25528375,New members of the mammalian glycerophosphodiester phosphodiesterase family: GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity.,2015,10.1074/jbc.m114.614537,https://pubmed.ncbi.nlm.nih.gov/25528375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,25596343,Glycerophosphodiesterase GDE4 as a novel lysophospholipase D: a possible involvement in bioactive N-acylethanolamine biosynthesis.,2015,10.1016/j.bbalip.2015.01.002,https://pubmed.ncbi.nlm.nih.gov/25596343/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,31455729,Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice.,2019,10.1073/pnas.1908736116,https://pubmed.ncbi.nlm.nih.gov/31455729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,34782205,Hepatotoxicity induced by PPⅥ and PPⅦ in zebrafish were related to the Cholesterol disorder.,2022,10.1016/j.phymed.2021.153787,https://pubmed.ncbi.nlm.nih.gov/34782205/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,28843504,Mammalian enzymes responsible for the biosynthesis of N-acylethanolamines.,2017,10.1016/j.bbalip.2017.08.006,https://pubmed.ncbi.nlm.nih.gov/28843504/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,18991142,"Isolation, characterization and molecular 3D model of human GDE4, a novel membrane protein containing glycerophosphodiester phosphodiesterase domain.",2008,10.1080/09687680802537605,https://pubmed.ncbi.nlm.nih.gov/18991142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,27637550,Calcium-dependent generation of N-acylethanolamines and lysophosphatidic acids by glycerophosphodiesterase GDE7.,2016,10.1016/j.bbalip.2016.09.008,https://pubmed.ncbi.nlm.nih.gov/27637550/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GDPD1,ENSG00000153982,Unsafe,16147865,"A novel splice variant of human gene NPL, mainly expressed in human liver, kidney and peripheral blood leukocyte.",2005,10.1080/10425170400020373,https://pubmed.ncbi.nlm.nih.gov/16147865/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,41977222,Reduced &lt;i&gt;GEN1&lt;/i&gt; Expression Is Associated with Elevated DNA Damage and Impaired Proliferation in Endometriosis-Derived Endometrial Organoids.,2026,10.3390/ijms27073034,https://pubmed.ncbi.nlm.nih.gov/41977222/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,42271441,Association analysis of germline variants in GEN1 with a susceptibility to prostate cancer in Polish men.,2026,10.1186/s13053-026-00343-0,https://pubmed.ncbi.nlm.nih.gov/42271441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,42623469,RAD51 stabilizes neutrophil extracellular traps to compartmentalize inflammation.,2026,10.1126/science.aed9286,https://pubmed.ncbi.nlm.nih.gov/42623469/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,40837761,"&lt;i&gt;GEN1&lt;/i&gt; regulates cell proliferation, migration, apoptosis and ferroptosis in gastric cancer.",2025,10.4251/wjgo.v17.i8.106781,https://pubmed.ncbi.nlm.nih.gov/40837761/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,40649769,Analysis of &lt;i&gt;GEN1&lt;/i&gt; as a Breast Cancer Susceptibility Gene in Polish Women.,2025,10.3390/ijms26135991,https://pubmed.ncbi.nlm.nih.gov/40649769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,42620630,Integrative evolutionary and structural modeling of leaf rust resistance genes in wheat (&lt;i&gt;Triticum aestivum&lt;/i&gt; subsp. and &lt;i&gt;T. monococcum&lt;/i&gt;).,2026,10.3389/fpls.2026.1867181,https://pubmed.ncbi.nlm.nih.gov/42620630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,42257465,Integrative multi-omics analysis-based Mendelian randomization identifies association of DNA repair-related genes with oral cancer.,2026,10.1177/18758592261455209,https://pubmed.ncbi.nlm.nih.gov/42257465/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,41267141,Engaging longitudinal cohort participants in a research priority setting process for the Raine Study.,2025,10.1186/s40900-025-00805-0,https://pubmed.ncbi.nlm.nih.gov/41267141/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,40405248,Host genome drives the microbiota enrichment of beneficial microbes in shrimp: exploring the hologenome perspective.,2025,10.1186/s42523-025-00414-y,https://pubmed.ncbi.nlm.nih.gov/40405248/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,38890669,Functional genetic variants of GEN1 predict overall survival of Chinese epithelial ovarian cancer patients.,2024,10.1186/s12967-024-05236-1,https://pubmed.ncbi.nlm.nih.gov/38890669/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,40920868,A novel DNA repair-independent role for Gen nuclease in promoting unscheduled polyploidy cell proliferation.,2025,10.1371/journal.pgen.1011605,https://pubmed.ncbi.nlm.nih.gov/40920868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,38654324,GEN1 as a risk factor for human congenital anomalies of the kidney and urinary tract.,2024,10.1186/s40246-024-00606-8,https://pubmed.ncbi.nlm.nih.gov/38654324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,42124239,Structural Optimization of Magnesium Alloy Rib Claw and Evaluation of Its Mechanical Reliability In Vitro and In Vivo.,2026,10.3390/ma19091833,https://pubmed.ncbi.nlm.nih.gov/42124239/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,39837652,Comparative image quality and dosimetric performance of two generations of dedicated breast CT systems.,2025,10.1002/mp.17623,https://pubmed.ncbi.nlm.nih.gov/39837652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,41614900,Exploration and Preliminary Investigation of Wiled Tinospora crispa: A Medicinal Plant with Promising Anti-Inflammatory and Antioxidant Properties.,2026,10.3390/cimb48010070,https://pubmed.ncbi.nlm.nih.gov/41614900/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,42105598,"Efficacy of olaparib in advanced cancers with somatic or germline mutations in BAP1, BARD1, BRIP1 and PALB2.",2026,10.1016/j.esmoop.2026.107693,https://pubmed.ncbi.nlm.nih.gov/42105598/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,41059097,Bidirectional dynamic threshold SNN for enhanced object detection with rich spike information.,2025,10.3389/fnins.2025.1661916,https://pubmed.ncbi.nlm.nih.gov/41059097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,38945198,Involvement of multiple epigenetic mechanisms by altered DNA methylation from the early stage of renal carcinogenesis before proliferative lesion formation upon repeated administration of ochratoxin A.,2024,10.1016/j.tox.2024.153875,https://pubmed.ncbi.nlm.nih.gov/38945198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,41201978,Monogenic Contributions to Familial Endometriosis: A Scoping Review.,2026,10.1159/000549442,https://pubmed.ncbi.nlm.nih.gov/41201978/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,37840312,Reverse Transcription-PCR-based Sanger Sequencing-confirmed Exon-skipping Effect of a Novel GEN1 Intronic Variant (c.1408+4A>G).,2024,10.3343/alm.2023.0163,https://pubmed.ncbi.nlm.nih.gov/37840312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,39640282,A phase II study evaluating safety and efficacy of niraparib in patients with previously treated homologous recombination defective metastatic esophageal/gastroesophageal junction/proximal gastric adenocarcinoma.,2024,10.3389/fonc.2024.1435056,https://pubmed.ncbi.nlm.nih.gov/39640282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,41228802,PMRVT: Parallel Attention Multilayer Perceptron Recurrent Vision Transformer for Object Detection with Event Cameras.,2025,10.3390/s25216580,https://pubmed.ncbi.nlm.nih.gov/41228802/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,41255557,Efficient and real-time perception: a survey on end-to-end event-based object detection in autonomous driving.,2025,10.3389/frobt.2025.1674421,https://pubmed.ncbi.nlm.nih.gov/41255557/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,36190107,The structure-selective endonucleases GEN1 and MUS81 mediate complementary functions in safeguarding the genome of proliferating B lymphocytes.,2022,10.7554/elife.77073,https://pubmed.ncbi.nlm.nih.gov/36190107/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,38012657,"Testing the association between shoulder pain prevalence and occupational, physical activity, and mental health factors in two generations of Australian adults.",2023,10.1186/s12998-023-00520-1,https://pubmed.ncbi.nlm.nih.gov/38012657/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,35962345,Germline genetic biomarkers to stratify patients for personalized radiation treatment.,2022,10.1186/s12967-022-03561-x,https://pubmed.ncbi.nlm.nih.gov/35962345/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,34928393,Canonical and novel non-canonical activities of the Holliday junction resolvase Yen1.,2022,10.1093/nar/gkab1225,https://pubmed.ncbi.nlm.nih.gov/34928393/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,39178368,DNA-Damaging Therapies in Patients With Prostate Cancer and Pathogenic Alterations in Homologous Recombination Repair Genes.,2024,10.1200/po.24.00014,https://pubmed.ncbi.nlm.nih.gov/39178368/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,39544409,Pressure and cold pain threshold reference values in a pain-free older adult population.,2025,10.1177/20494637241276104,https://pubmed.ncbi.nlm.nih.gov/39544409/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,32729768,Has the Sun Protection Campaign in Australia Reduced the Need for Pterygium Surgery Nationally?,2021,10.1080/09286586.2020.1797120,https://pubmed.ncbi.nlm.nih.gov/32729768/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,29414053,Collaboration in the actions of Brh2 with resolving functions during DNA repair and replication stress in Ustilago maydis.,2018,10.1016/j.dnarep.2018.01.010,https://pubmed.ncbi.nlm.nih.gov/29414053/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,26682650,Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage.,2015,10.7554/elife.12256,https://pubmed.ncbi.nlm.nih.gov/26682650/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,36429961,Associations between Prenatal Exposure to Phthalates and Features of the Metabolic Syndrome in Males from Childhood into Adulthood.,2022,10.3390/ijerph192215244,https://pubmed.ncbi.nlm.nih.gov/36429961/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GEN1,ENSG00000178295,Unsafe,33497062,Prenatal Exposure to General Anesthesia and Childhood Behavioral Deficit.,2021,10.1213/ane.0000000000005389,https://pubmed.ncbi.nlm.nih.gov/33497062/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,42670403,Nano guar gum triphenyl phosphonium conjugated rutin complex ameliorates hypertrophy in H9c2 cells via mitochondrial-mediated pathways.,2026,10.1007/s10616-026-01045-0,https://pubmed.ncbi.nlm.nih.gov/42670403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,40586835,Functional remodeling of tissue-resident macrophages leads to distinct immune microenvironment evolution and clinical manifestations in lung adenocarcinoma.,2025,10.1007/s10238-025-01760-6,https://pubmed.ncbi.nlm.nih.gov/40586835/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,42152310,Spectral CT imaging in quantitative analysis of GGN: A primary feasibility study.,2026,10.1097/md.0000000000048720,https://pubmed.ncbi.nlm.nih.gov/42152310/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,42294453,Multiple ground-glass nodules after lobectomy for multiple primary lung cancer: a case report.,2026,10.3389/fsurg.2026.1842030,https://pubmed.ncbi.nlm.nih.gov/42294453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,40887608,Relationships between growth rate and Ki-67 and immune indices in ground-glass nodule-featured lung adenocarcinoma.,2025,10.1186/s12885-025-14078-z,https://pubmed.ncbi.nlm.nih.gov/40887608/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,41676285,Predictive value of the combined application of oxidative stress indicators and carcinoembryonic antigen for patients with early lung adenocarcinoma.,2026,10.62347/zwfw6679,https://pubmed.ncbi.nlm.nih.gov/41676285/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,41310662,Association of multi-site microbial features with malignancy risk in pulmonary ground-glass nodules and identification of predictive biomarkers: a prospective multicenter cohort study.,2025,10.1186/s12967-025-07483-2,https://pubmed.ncbi.nlm.nih.gov/41310662/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,42890222,Stage-specific transcriptional atlas of goose satellite cells uncovers sex-biased molecular dynamics associated with embryonic skeletal muscle development.,2026,10.3389/fcell.2026.1957937,https://pubmed.ncbi.nlm.nih.gov/42890222/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,41958752,Robotic-Assisted CT-Guided Synchronous Percutaneous Lung Biopsy and Cryoablation for Pulmonary Sub-Solid Nodule: A Case Report.,2026,10.1002/rcr2.70436,https://pubmed.ncbi.nlm.nih.gov/41958752/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,39580469,Single-cell RNA sequencing reveals immune microenvironment niche transitions during the invasive and metastatic processes of ground-glass nodules and part-solid nodules in lung adenocarcinoma.,2024,10.1186/s12943-024-02177-7,https://pubmed.ncbi.nlm.nih.gov/39580469/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,40031964,GGN repeat length of the androgen receptor gene is associated with antral follicle count in Chinese women undergoing controlled ovarian stimulation.,2025,10.12122/j.issn.1673-4254.2025.02.01,https://pubmed.ncbi.nlm.nih.gov/40031964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,41625584,Primary pulmonary adenoid cystic carcinoma presenting with ground-glass opacity nodules coexisting with male breast adenoid cystic carcinoma: A case report.,2026,10.1016/j.radcr.2025.12.035,https://pubmed.ncbi.nlm.nih.gov/41625584/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,39839794,A novel interplay between bacteria and metabolites in different early-stage lung cancer: an integrated microbiome and metabolome analysis.,2024,10.3389/fonc.2024.1492571,https://pubmed.ncbi.nlm.nih.gov/39839794/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,40948741,MiRNA sequencing of platelet and exosome revealed platelet miR-199b-3p as a potential biomarker in lung adenocarcinoma.,2025,10.3389/fimmu.2025.1619448,https://pubmed.ncbi.nlm.nih.gov/40948741/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,41473045,Decoding intertumoral heterogeneity in multifocal ground-glass nodule lung cancers: Clonal evolutionary insight for precision management.,2025,10.1016/j.xjon.2025.09.009,https://pubmed.ncbi.nlm.nih.gov/41473045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,40636359,Assessment of extracellular vesicle microRNAs detection in predicting benign and malignant pulmonary ground glass nodules.,2025,10.3389/fmed.2025.1600429,https://pubmed.ncbi.nlm.nih.gov/40636359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,42421696,Atypical Spread With Lung Shrinkage and Cystic Changes in Bilateral Lepidic Adenocarcinoma.,2026,10.1002/rcr2.70666,https://pubmed.ncbi.nlm.nih.gov/42421696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,40242403,Novel causes and assessments of intrapulmonary metastasis.,2025,10.1016/j.bbrep.2025.102004,https://pubmed.ncbi.nlm.nih.gov/40242403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,41960092,Cryoablation for ground-glass nodules: Indications and short-term outcomes.,2026,10.1016/j.xjon.2025.101548,https://pubmed.ncbi.nlm.nih.gov/41960092/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,41790651,Predictive value of high-resolution computed tomography radiomics for assessing the invasiveness of pulmonary adenocarcinoma presenting as ground-glass nodules: A retrospective study.,2026,10.1097/md.0000000000047964,https://pubmed.ncbi.nlm.nih.gov/41790651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,41182404,"The impact of tislelizumab immunotherapy on multiple primary lung cancer presenting as ground-glass nodules: preliminary results analysis from a single-arm, phase II trial.",2025,10.1007/s00262-025-04212-y,https://pubmed.ncbi.nlm.nih.gov/41182404/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,41985057,Prediction of minimum inhibitory concentration of antibacterial peptides using geometric graph networks and dynamic loss functions.,2026,10.1093/bib/bbag170,https://pubmed.ncbi.nlm.nih.gov/41985057/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,42415465,GGOC-AD: a mHealth tool to challenge obsessive-compulsive related maladaptive beliefs in Spanish community adolescents: a randomized controlled trial.,2026,10.1111/camh.70110,https://pubmed.ncbi.nlm.nih.gov/42415465/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,41981520,Application of percutaneous cryoablation for pulmonary nodules and influence in pulmonary function.,2026,10.1186/s12885-026-15929-z,https://pubmed.ncbi.nlm.nih.gov/41981520/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,42266216,Research advances of tubeless thoracic surgery for pulmonary nodules: current status and future challenges.,2026,10.3389/fsurg.2026.1834893,https://pubmed.ncbi.nlm.nih.gov/42266216/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,42017975,Artificial intelligence construction: a review of the bridge between CT imaging features of lung ground-glass nodules adenocarcinoma and carcinogenic driver genes.,2026,10.1007/s00432-026-06465-1,https://pubmed.ncbi.nlm.nih.gov/42017975/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,42701479,Efficacy and safety of the RC120 navigation system for the computed tomography-guided localization of pulmonary ground-glass nodules: a prospective study with historical controls.,2026,10.21037/qims-2026-1-0300,https://pubmed.ncbi.nlm.nih.gov/42701479/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,41045356,"Microwave ablation for residual ground-glass nodule-like lung cancer after video-assisted thoracoscopic surgery: a retrospective, large-sample, multicenter study.",2026,10.1007/s11547-025-02112-w,https://pubmed.ncbi.nlm.nih.gov/41045356/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,42903588,"Reconstruction-aware radiomics for risk stratification of subsolid pulmonary nodules: technical evidence, clinical limits, and translation priorities.",2026,10.3389/fmed.2026.1955926,https://pubmed.ncbi.nlm.nih.gov/42903588/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,39197870,Safety and efficacy of a novel transbronchial radiofrequency ablation system for lung tumours: One year follow-up from the first multi-centre large-scale clinical trial (BRONC-RFII).,2025,10.1111/resp.14822,https://pubmed.ncbi.nlm.nih.gov/39197870/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,41697887,CT-guided Preoperative Localization of Pulmonary Nodules Using a Glucose Test and Tissue Adhesive.,2026,10.3791/69161,https://pubmed.ncbi.nlm.nih.gov/41697887/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGN,ENSG00000179168,Unsafe,39235522,Immunogenomic features of radiologically distinctive nodules in multiple primary lung cancer.,2024,10.1007/s00262-024-03807-1,https://pubmed.ncbi.nlm.nih.gov/39235522/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGTLC2,ENSG00000100121,Unsafe,42499506,Correction: Crocin promotes ferroptosis in gastric cancer via the Nrf2/GGTLC2 pathway.,2026,10.3389/fphar.2026.1901759,https://pubmed.ncbi.nlm.nih.gov/42499506/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGTLC2,ENSG00000100121,Unsafe,40191433,Crocin promotes ferroptosis in gastric cancer via the Nrf2/GGTLC2 pathway.,2025,10.3389/fphar.2025.1527481,https://pubmed.ncbi.nlm.nih.gov/40191433/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGTLC2,ENSG00000100121,Unsafe,40397220,"The ferroptosis-related gene GGTLC2 is identified as a novel biomarker for gastric cancer within the GGT family, with associations to immune infiltration and liver metastasis.",2025,10.1007/s10142-025-01614-0,https://pubmed.ncbi.nlm.nih.gov/40397220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGTLC2,ENSG00000100121,Unsafe,35143416,A web-based calculator for predicting the prognosis of patients with sarcoma on the basis of antioxidant gene signatures.,2022,10.18632/aging.203885,https://pubmed.ncbi.nlm.nih.gov/35143416/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGTLC2,ENSG00000100121,Unsafe,19027161,Array CGH analysis of chronic lymphocytic leukemia reveals frequent cryptic monoallelic and biallelic deletions of chromosome 22q11 that include the PRAME gene.,2009,10.1016/j.leukres.2008.10.010,https://pubmed.ncbi.nlm.nih.gov/19027161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GGTLC2,ENSG00000100121,Unsafe,18357469,The human gamma-glutamyltransferase gene family.,2008,10.1007/s00439-008-0487-7,https://pubmed.ncbi.nlm.nih.gov/18357469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,42178336,"VISFATIN: a novel modulator of placental endocrinology under physiological and pathological conditions-in vitro studies involving INSR, ERK1/2, and PKA signalling pathways.",2026,10.1038/s41598-026-52422-w,https://pubmed.ncbi.nlm.nih.gov/42178336/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,42293194,Excess folic acid disrupts placental endocrine function &lt;i&gt;in vitro&lt;/i&gt;: a potential mechanism linking elevated folic acid exposure with gestational diabetes mellitus.,2026,10.3389/fnut.2026.1813142,https://pubmed.ncbi.nlm.nih.gov/42293194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,40524488,The 20 kDa isoform of the human growth hormone variant alters adipose and muscle gene expression differently than human growth hormone.,2025,10.1111/jne.70059,https://pubmed.ncbi.nlm.nih.gov/40524488/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,42795541,Segment-Specific Gut Microbiome and Bile Acid Profiles in Grazing and Stall-Fed Yaks.,2026,10.3390/microorganisms14091960,https://pubmed.ncbi.nlm.nih.gov/42795541/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,42353160,Differential Biotransformation of Glycyrrhizin by Licorice-Derived Endophytic Fungi and Accumulation-Promoting Effects of Fungal Inoculation.,2026,10.3390/ijms27125444,https://pubmed.ncbi.nlm.nih.gov/42353160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,40635069,Division of the large and multifunctional glycoside hydrolase family 2: high functional specificity and biochemical assays in the uncharacterized subfamilies.,2025,10.1186/s13068-025-02669-8,https://pubmed.ncbi.nlm.nih.gov/40635069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,38656801,Nkd1 functions downstream of Axin2 to attenuate Wnt signaling.,2024,10.1091/mbc.e24-02-0059-t,https://pubmed.ncbi.nlm.nih.gov/38656801/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,40944254,"Maternal Folate Excess, Placental Hormones, and Gestational Diabetes Mellitus: Findings from Prospective Cohorts Before and After Mandatory Folic Acid Food Fortification.",2025,10.3390/nu17172863,https://pubmed.ncbi.nlm.nih.gov/40944254/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,41487261,A GH42 β‑Galactosidase from the Human Isolate &lt;i&gt;Bifidobacterium breve&lt;/i&gt; DSM 20213: Biochemical and Transgalactosylation Properties Reveal the Potential for Galacto-oligosaccharides Synthesis.,2025,10.1021/acsomega.5c06811,https://pubmed.ncbi.nlm.nih.gov/41487261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,39287299,Effect of different growth hormone pretreatment times in assisted reproductive therapy for patients with diminished ovarian reserve: A retrospective pilot cohort study.,2024,10.1097/md.0000000000039645,https://pubmed.ncbi.nlm.nih.gov/39287299/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,36848146,Evolution of the Growth Hormone Gene Duplication in Passerine Birds.,2023,10.1093/gbe/evad033,https://pubmed.ncbi.nlm.nih.gov/36848146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,41200871,"Association of Human Cytomegalovirus Glycoprotein B, H, and O Variants and MBL2 Gene Polymorphisms With Clinical Manifestations in CMV-Infected Neonates in Shanghai.",2025,10.1002/jmv.70689,https://pubmed.ncbi.nlm.nih.gov/41200871/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,40362658,Evidence for Pituitary Repression of the Human Growth Hormone-Related Placental Lactogen Genes and a Role for P Sequences.,2025,10.3390/ijms26094421,https://pubmed.ncbi.nlm.nih.gov/40362658/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,41833387,Physiological and biochemical changes and microbial community succession during the postharvest rot process of Stropharia rugosoannulata.,2026,10.2323/jgam.2026.03.001,https://pubmed.ncbi.nlm.nih.gov/41833387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,41491304,A disulfide redox switch mechanism regulates glycoside hydrolase function.,2026,10.1038/s41467-025-67225-2,https://pubmed.ncbi.nlm.nih.gov/41491304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,41810553,Sequence-Based and Functional Analysis for the Discovery of N-Glycan Degrading Glycosidases From the Microbial Metagenome of the Infant Gut.,2026,10.1002/mbo3.70264,https://pubmed.ncbi.nlm.nih.gov/41810553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,41011365,"Characterization and Optimization of Fermentation Conditions of &lt;i&gt;Roseateles&lt;/i&gt; sp. L2-2, a Novel Chitin-Degrading Bacterium from the Intestine of &lt;i&gt;Odorrana margaretae&lt;/i&gt;.",2025,10.3390/microorganisms13092033,https://pubmed.ncbi.nlm.nih.gov/41011365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,40277444,"Quaternary stabilization of a GH2 β-galactosidase from the psychrophile A. ikkensis, a flexible and unstable dimeric enzyme.",2025,10.1002/pro.70141,https://pubmed.ncbi.nlm.nih.gov/40277444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,41302403,Characterization of a β-Galactosidase from &lt;i&gt;Kosakonia oryzendophytica&lt;/i&gt; and Its Heterologous Expression in &lt;i&gt;Bacillus subtilis&lt;/i&gt; for Galactooligosaccharides Production.,2025,10.3390/molecules30224343,https://pubmed.ncbi.nlm.nih.gov/41302403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,40105703,Evolution of the Complex Growth Hormone Gene Cluster in Macaques.,2025,10.1210/endocr/bqaf056,https://pubmed.ncbi.nlm.nih.gov/40105703/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,42459333,&lt;i&gt;In-silico&lt;/i&gt; analysis of &lt;i&gt;Bifidobacterium bifidum&lt;/i&gt; strain 900791 genome in the context of the &lt;i&gt;B. bifidum&lt;/i&gt; pangenome.,2026,10.3389/fcimb.2026.1744409,https://pubmed.ncbi.nlm.nih.gov/42459333/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,42784842,Intestinal mucus promotes microbial degradation of bamboo fiber in an in vitro giant panda gut fermentation system.,2026,10.1093/jambio/lxag242,https://pubmed.ncbi.nlm.nih.gov/42784842/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,40274137,C-terminal domains of β-galactosidase from Paenibacillus macquariensis modulate product distribution by altering substrate binding conformation.,2025,10.1016/j.ijbiomac.2025.143412,https://pubmed.ncbi.nlm.nih.gov/40274137/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,40779185,Comparative genomic analysis of Paraclostridium bifermentans in the intestinal microbiome of Hu sheep.,2025,10.1007/s11259-025-10854-1,https://pubmed.ncbi.nlm.nih.gov/40779185/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,39113357,T-cell specific in vivo gene delivery with DART-AAVs targeted to CD8.,2024,10.1016/j.ymthe.2024.08.002,https://pubmed.ncbi.nlm.nih.gov/39113357/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,41514431,Bioconversion of lignin and food waste into vanillin and biohydrogen by Escherichia coli MC3: a novel dual-functional bacteria.,2026,10.1186/s13068-025-02728-0,https://pubmed.ncbi.nlm.nih.gov/41514431/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,40263859,Fermentation of Ngoc Linh ginseng (Panax vietnamensis Ha et Grushv.) root extract using Levilactobacillus brevis QD-1: Changes in majonoside R2 content and pharmacological activities.,2025,10.1016/j.foodres.2025.116275,https://pubmed.ncbi.nlm.nih.gov/40263859/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,40564325,"Multi-Omics Revealed the Effects of Different Feeding Systems on Rumen Microorganisms, Cellulose Degradation, and Metabolites in Mongolian Cattle.",2025,10.3390/ani15121774,https://pubmed.ncbi.nlm.nih.gov/40564325/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,38111384,Milk-y Way: the impact of single-nucleotide polymorphisms on milk production traits in Kilis dairy goats.,2023,10.5194/aab-66-369-2023,https://pubmed.ncbi.nlm.nih.gov/38111384/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,40636496,Host-driven remodeling of rumen microbiota supports lactation metabolism in buffalo.,2025,10.3389/fmicb.2025.1617388,https://pubmed.ncbi.nlm.nih.gov/40636496/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,39256599,Impact of ginsenoside Rb1 on gut microbiome and associated changes in pharmacokinetics in rats.,2024,10.1038/s41598-024-72225-1,https://pubmed.ncbi.nlm.nih.gov/39256599/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,37049394,"Elevated Maternal Folate Status and Changes in Maternal Prolactin, Placental Lactogen and Placental Growth Hormone Following Folic Acid Food Fortification: Evidence from Two Prospective Pregnancy Cohorts.",2023,10.3390/nu15071553,https://pubmed.ncbi.nlm.nih.gov/37049394/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GH2,ENSG00000136487,Unsafe,34729380,Lentiviral and adeno-associated vectors efficiently transduce mouse T lymphocytes when targeted to murine CD8.,2021,10.1016/j.omtm.2021.09.014,https://pubmed.ncbi.nlm.nih.gov/34729380/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,42903841,GINS1 suppresses ferroptosis by inhibiting the Hippo pathway in neuroblastoma.,2026,10.1080/23723556.2026.2715868,https://pubmed.ncbi.nlm.nih.gov/42903841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,41776634,Unraveling the oncogenic and immunomodulatory roles of GINS1: a systematic pan-cancer study.,2026,10.1186/s12935-026-04252-z,https://pubmed.ncbi.nlm.nih.gov/41776634/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,42295485,"Multi-omics analysis identifies GINS1 as a prognostic biomarker in lung adenocarcinoma, linked to macrophage polarization and tumor cell survival.",2026,10.1007/s12672-026-05454-7,https://pubmed.ncbi.nlm.nih.gov/42295485/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,41242545,Oncogenic GINS1 facilitates cervical cancer progression via FYN-mediated EMT regulation.,2026,10.1016/j.lfs.2025.124090,https://pubmed.ncbi.nlm.nih.gov/41242545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,40713555,Epicatechin attenuates the stemness of liver cancer stem cells and tumorigenesis through DNA methylation-mediated inactivation of GINS1/HRAS.,2025,10.1186/s12967-025-06790-y,https://pubmed.ncbi.nlm.nih.gov/40713555/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,42050845,A Unified Framework for Statistical Inference and Power Analysis of Single and Comparative $$ {F}_{\beta } $$ Scores.,2026,10.1002/sim.70557,https://pubmed.ncbi.nlm.nih.gov/42050845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,40197379,GINS1 facilitates the development of lung adenocarcinoma via Wnt/β-catenin activation.,2025,10.1186/s12957-025-03786-2,https://pubmed.ncbi.nlm.nih.gov/40197379/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,41689265,Expanding Phenotype of GINS1 Deficiency: A Case Report and Review of the Literature.,2026,10.1111/cge.70147,https://pubmed.ncbi.nlm.nih.gov/41689265/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,40123906,GINS1 is a prognostic biomarker and correlated with methylation and immune escape in liver hepatocellular carcinoma.,2025,10.3389/fonc.2025.1492599,https://pubmed.ncbi.nlm.nih.gov/40123906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,41893924,"Role of POLE2/GINS1-mediated AKT/mTOR pathway in RCC autophagy, proliferation, and metastasis: evidences from bioinformatic, clinical, and experimental data.",2026,10.1007/s10495-025-02206-w,https://pubmed.ncbi.nlm.nih.gov/41893924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,40957326,Pan-cancer analysis of GINS1 identifies its prognostic and immunotherapy predictive value with in vitro experimental validation in nasopharyngeal carcinoma.,2025,10.1016/j.imbio.2025.153114,https://pubmed.ncbi.nlm.nih.gov/40957326/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,40381037,3'UTR RNA editing driven by ADAR1 modulates MDM2 expression in breast cancer cells.,2025,10.1007/s10142-025-01611-3,https://pubmed.ncbi.nlm.nih.gov/40381037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,39631830,"[GINS1 Enhances Glycolysis, Proliferation and Metastasis in Lung Adenocarcinoma Cells by Activating the Notch/PI3K/AKT/mTORC1 Signaling Pathway].",2024,10.3779/j.issn.1009-3419.2024.101.27,https://pubmed.ncbi.nlm.nih.gov/39631830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,39210373,"OTU deubiquitinase, ubiquitin aldehyde binding 2  (OTUB2) modulates the stemness feature, chemoresistance, and epithelial-mesenchymal transition of colon cancer via regulating GINS complex subunit 1 (GINS1) expression.",2024,10.1186/s12964-024-01789-2,https://pubmed.ncbi.nlm.nih.gov/39210373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,36482653,Progress of Psf1 and prospects in the tumor: A review.,2022,10.1097/md.0000000000031811,https://pubmed.ncbi.nlm.nih.gov/36482653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,40723231,MicroRNA Signatures in Lung Adenocarcinoma Metastases: Exploring the Oncogenic Targets of Tumor-Suppressive &lt;i&gt;miR-195-5p&lt;/i&gt; and &lt;i&gt;miR-195-3p&lt;/i&gt;.,2025,10.3390/cancers17142348,https://pubmed.ncbi.nlm.nih.gov/40723231/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,39280654,"Comprehensive analysis of GINS subunit expression, prognostic value, and immune infiltration in clear cell renal cell carcinoma.",2024,10.21037/tau-24-95,https://pubmed.ncbi.nlm.nih.gov/39280654/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,41975518,Cross-species single-cell transcriptomic analyses reveal evolutionary conservation and diversification of ovarian tissues.,2026,10.1186/s40104-026-01383-1,https://pubmed.ncbi.nlm.nih.gov/41975518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,38880324,GINS1 promotes the initiation and progression of bladder cancer by activating the AKT/mTOR/c-Myc signaling pathway.,2024,10.1016/j.yexcr.2024.114125,https://pubmed.ncbi.nlm.nih.gov/38880324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,37576391,FOXP1-GINS1 axis promotes DLBCL proliferation and directs doxorubicin resistance.,2023,10.7150/jca.85906,https://pubmed.ncbi.nlm.nih.gov/37576391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,40653247,A cold-adapted endo-fucoidanase Psf1 from Pseudoalteromonas sp. that catalyzes production of T-cell activating fucoidan oligosaccharides from Saccharina latissima fucoidan.,2025,10.1016/j.ijbiomac.2025.145930,https://pubmed.ncbi.nlm.nih.gov/40653247/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,37180662,Identification of GINS1 as a potential prognostic biomarker for sarcoma using bioinformatic analysis.,2023,10.21037/tcr-23-524,https://pubmed.ncbi.nlm.nih.gov/37180662/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,37221950,PAX5 and circ1857 affected DLBCL progression and B-cell proliferation through regulating GINS1.,2023,10.1111/cas.15856,https://pubmed.ncbi.nlm.nih.gov/37221950/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,37904396,Roles of DSCC1 and GINS1 in gastric cancer.,2023,10.1097/md.0000000000035681,https://pubmed.ncbi.nlm.nih.gov/37904396/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,38301047,Complementary biomarkers of computed tomography for diagnostic grading of gastric cancer: DSCC1 and GINS1.,2024,10.18632/aging.205491,https://pubmed.ncbi.nlm.nih.gov/38301047/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,40312720,Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma.,2025,10.1186/s12943-025-02333-7,https://pubmed.ncbi.nlm.nih.gov/40312720/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,38809096,Replication Stress in Activated Human NK Cells Induces Sensitivity to Apoptosis.,2024,10.4049/jimmunol.2300843,https://pubmed.ncbi.nlm.nih.gov/38809096/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,40510848,Expanding the phenotypic and genetic landscape of congenital neutropenia through whole-exome and genome sequencing.,2025,10.1002/hem3.70150,https://pubmed.ncbi.nlm.nih.gov/40510848/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,39811603,Functional Analysis and Experimental Validation of the Prognostic and Immune Effects of the Oncogenic Protein CDC45 in Breast Cancer.,2025,10.2147/bctt.s497975,https://pubmed.ncbi.nlm.nih.gov/39811603/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,41409294,Identification of MUC5B as a lymph node metastasis-associated gene in lung adenocarcinoma through integrated transcriptomic and machine learning approaches.,2025,10.3389/fimmu.2025.1666240,https://pubmed.ncbi.nlm.nih.gov/41409294/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,36092720,Comprehensive analysis of GINS subunits prognostic value and ceRNA network in sarcoma.,2022,10.3389/fcell.2022.951363,https://pubmed.ncbi.nlm.nih.gov/36092720/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS1,ENSG00000101003,Unsafe,36345721,Gene interaction perturbation network deciphers a high-resolution taxonomy in colorectal cancer.,2022,10.7554/elife.81114,https://pubmed.ncbi.nlm.nih.gov/36345721/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,42575893,Nuclear compartmentalization at the G1/S transition plays a key role in DNA replication control.,2026,10.1038/s41467-026-75264-6,https://pubmed.ncbi.nlm.nih.gov/42575893/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,41192616,The α5-nAChR/GINS4 axis contributed to nicotine-promoted lung adenocarcinoma progression.,2026,10.1016/j.fct.2025.115828,https://pubmed.ncbi.nlm.nih.gov/41192616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,41144169,GINS4 Promotes Neonatal Bronchopulmonary Dysplasia via Driving Phosphorylation and Acetylation of p65 NF-κB.,2026,10.1007/s12033-025-01505-6,https://pubmed.ncbi.nlm.nih.gov/41144169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,40768335,Allelic bias contributes to heterogeneous phenotypes of NK cell deficiency.,2025,10.1016/j.celrep.2025.116102,https://pubmed.ncbi.nlm.nih.gov/40768335/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,40081544,"GINS4 silencing mediates hepatocellular cancer cell proliferation, cycle and ferroptosis through POLE2.",2025,10.1016/j.cellsig.2025.111742,https://pubmed.ncbi.nlm.nih.gov/40081544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,36345943,Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia.,2022,10.1172/jci.insight.154948,https://pubmed.ncbi.nlm.nih.gov/36345943/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,41409294,Identification of MUC5B as a lymph node metastasis-associated gene in lung adenocarcinoma through integrated transcriptomic and machine learning approaches.,2025,10.3389/fimmu.2025.1666240,https://pubmed.ncbi.nlm.nih.gov/41409294/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,37018198,GINS4 suppresses ferroptosis by antagonizing p53 acetylation with Snail.,2023,10.1073/pnas.2219585120,https://pubmed.ncbi.nlm.nih.gov/37018198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,37508549,The Molecular Pathogenesis of Tumor-Suppressive miR-486-5p and miR-486-3p Target Genes: GINS4 Facilitates Aggressiveness in Lung Adenocarcinoma.,2023,10.3390/cells12141885,https://pubmed.ncbi.nlm.nih.gov/37508549/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,34556022,Overexpression of GINS4 is associated with poor prognosis and survival in glioma patients.,2021,10.1186/s10020-021-00378-0,https://pubmed.ncbi.nlm.nih.gov/34556022/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,39811603,Functional Analysis and Experimental Validation of the Prognostic and Immune Effects of the Oncogenic Protein CDC45 in Breast Cancer.,2025,10.2147/bctt.s497975,https://pubmed.ncbi.nlm.nih.gov/39811603/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,37866880,Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7.,2024,10.1002/1878-0261.13537,https://pubmed.ncbi.nlm.nih.gov/37866880/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,36482653,Progress of Psf1 and prospects in the tumor: A review.,2022,10.1097/md.0000000000031811,https://pubmed.ncbi.nlm.nih.gov/36482653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,36273455,MicroRNA-133a-3p Inhibits Lung Adenocarcinoma Development and Cisplatin Resistance through Targeting GINS4.,2024,10.1159/000527684,https://pubmed.ncbi.nlm.nih.gov/36273455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,40963613,Assessment of gene signatures following the inhibition of IL-23: a study to evaluate the mechanistic effects behind the clinical efficacy of guselkumab in patients with psoriatic arthritis.,2025,10.3389/fimmu.2025.1672667,https://pubmed.ncbi.nlm.nih.gov/40963613/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,39778868,Cell cycle progression of under-replicated cells.,2025,10.1093/nar/gkae1311,https://pubmed.ncbi.nlm.nih.gov/39778868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,38809096,Replication Stress in Activated Human NK Cells Induces Sensitivity to Apoptosis.,2024,10.4049/jimmunol.2300843,https://pubmed.ncbi.nlm.nih.gov/38809096/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,35411239,A pan-cancer analysis of GINS complex subunit 4 to identify its potential role as a biomarker in multiple human cancers.,2022,,https://pubmed.ncbi.nlm.nih.gov/35411239/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,33842367,Overexpression of GINS4 Is Associated With Tumor Progression and Poor Survival in Hepatocellular Carcinoma.,2021,10.3389/fonc.2021.654185,https://pubmed.ncbi.nlm.nih.gov/33842367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,40577589,Mutational analysis of the Drosophila CMG helicase reveals relationships among chromosome integrity and the maintenance of spindle and centrosome structure.,2025,10.1093/genetics/iyaf124,https://pubmed.ncbi.nlm.nih.gov/40577589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,35365175,GINS4 might be a novel prognostic immune-related biomarker of not only esophageal squamous cell carcinoma and other cancers.,2022,10.1186/s12920-022-01223-x,https://pubmed.ncbi.nlm.nih.gov/35365175/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,40510848,Expanding the phenotypic and genetic landscape of congenital neutropenia through whole-exome and genome sequencing.,2025,10.1002/hem3.70150,https://pubmed.ncbi.nlm.nih.gov/40510848/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,34882534,Multiple RNA virus matrix proteins interact with SLD5 to manipulate host cell cycle.,2021,10.1099/jgv.0.001697,https://pubmed.ncbi.nlm.nih.gov/34882534/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,36819577,Identification of novel key genes associated with uterine corpus endometrial carcinoma progression and prognosis.,2023,10.21037/atm-22-6461,https://pubmed.ncbi.nlm.nih.gov/36819577/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,36345721,Gene interaction perturbation network deciphers a high-resolution taxonomy in colorectal cancer.,2022,10.7554/elife.81114,https://pubmed.ncbi.nlm.nih.gov/36345721/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,35896011,"Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma.",2022,10.18632/aging.204191,https://pubmed.ncbi.nlm.nih.gov/35896011/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,33725952,Expression and prognosis analysis of GINS subunits in human breast cancer.,2021,10.1097/md.0000000000024827,https://pubmed.ncbi.nlm.nih.gov/33725952/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,31637868,Psf3 as a possible biomarker of postoperative chemotherapy for patients with early pulmonary adenocarcinoma.,2019,10.1111/1759-7714.13230,https://pubmed.ncbi.nlm.nih.gov/31637868/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,30446701,"Unique, Intersecting, and Overlapping Roles of C/EBP β and CREB in Cells of the Innate Immune System.",2018,10.1038/s41598-018-35184-y,https://pubmed.ncbi.nlm.nih.gov/30446701/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GINS4,ENSG00000147536,Unsafe,17611626,Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression.,2007,10.1371/journal.pone.0000594,https://pubmed.ncbi.nlm.nih.gov/17611626/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42907365,Glucose-dependent insulinotropic polypeptide receptor regulates steroidogenic gene expression in the mouse testis and is modulated by metabolic and intracellular signaling factors.,2026,10.1292/jvms.26-0476,https://pubmed.ncbi.nlm.nih.gov/42907365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42470158,Molecular identification and functional characterization of glucose-dependent insulinotropic peptide (GIP) and its receptor (GIPR) in Micropterus salmoides.,2026,10.1111/jfb.70549,https://pubmed.ncbi.nlm.nih.gov/42470158/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42792587,Adipocytes as a Mechanistic Link Between Incretin-Based Therapies and Hair Loss.,2026,10.3390/biology15181642,https://pubmed.ncbi.nlm.nih.gov/42792587/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,41710720,Revitalizing GIP: Therapeutic Potential in Metabolic and Neurodegenerative Disorders.,2026,10.2147/dmso.s559587,https://pubmed.ncbi.nlm.nih.gov/41710720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42789930,The Role and Mechanism of Incretins in Gynaecologic Diseases.,2026,10.1002/edm2.70340,https://pubmed.ncbi.nlm.nih.gov/42789930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42754900,"Impact of GLP-1 and GLP-1/GIP receptor agonists before, during, and after pregnancy: a narrative review.",2026,10.1186/s13098-026-02235-8,https://pubmed.ncbi.nlm.nih.gov/42754900/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42595008,Conditional overexpression of PPARα in intestinal epithelium diminishes GIP enteroendocrine cells and circulating hormone levels.,2026,10.1016/j.molmet.2026.102429,https://pubmed.ncbi.nlm.nih.gov/42595008/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42907720,Glucose-dependent insulinotropic polypeptide (GIP) signaling in visceral and subcutaneous adipose tissue: implications for obesity and metabolic disease-a narrative review with a structured literature search.,2026,10.1007/s11154-026-10098-7,https://pubmed.ncbi.nlm.nih.gov/42907720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42794619,GLP-1 and Dual GIP/GLP-1 Receptor Agonists in Pediatric Obesity: From Neuroendocrine Mechanisms to Clinical Application.,2026,10.3390/ijms27188191,https://pubmed.ncbi.nlm.nih.gov/42794619/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42712058,Additive Glucagonotropic and Insulinotropic Effects of Glucose-Dependent Insulinotropic Polypeptide and Alanine in Fasted Healthy Men.,2026,10.1111/dom.71273,https://pubmed.ncbi.nlm.nih.gov/42712058/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42325559,Sleeve gastrectomy improves cognition by enhancing central ERK/CREB/BDNF pathway through increased GIP secretion.,2026,10.1016/j.isci.2026.116292,https://pubmed.ncbi.nlm.nih.gov/42325559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42899073,The incretin-bone axis: molecular mechanisms and clinical implications.,2026,10.3389/fendo.2026.1907875,https://pubmed.ncbi.nlm.nih.gov/42899073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42496592,GIP Acutely Blunts Insulin- and GLP-1-Induced Muscle Microvascular Perfusion.,2026,10.2337/db25-1009,https://pubmed.ncbi.nlm.nih.gov/42496592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42473065,Peptide LKLKLL is a more effective component of &lt;i&gt;Akkermansia muciniphila&lt;/i&gt; which regulate glucolipid metabolism through GLP-1/GIP dual modulation.,2026,10.1080/19490976.2026.2687937,https://pubmed.ncbi.nlm.nih.gov/42473065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42675474,Glucose-dependent insulinotropic polypeptide receptor agonism improves heart failure with antifibrosis through Akt-dependent nitric oxide signaling.,2026,10.1186/s12929-026-01288-1,https://pubmed.ncbi.nlm.nih.gov/42675474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42209267,GIP in Cardiovascular and Kidney Disease: From Physiology to Pharmacology.,2026,10.1111/dom.70888,https://pubmed.ncbi.nlm.nih.gov/42209267/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42487666,Personalization of incretin therapy: can GLP-1 and GIP receptor polymorphisms influence therapy response?,2026,10.1210/jendso/bvag149,https://pubmed.ncbi.nlm.nih.gov/42487666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42452530,Changes in GLP-1 and GIP During Endurance Training in Competitive Triathletes: A Pilot Observational Study.,2026,10.3390/jcm15135069,https://pubmed.ncbi.nlm.nih.gov/42452530/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,39951489,Glucose-Dependent Insulinotropic Polypeptide in Incretin Physiology: Role in Health and Disease.,2025,10.1210/endrev/bnaf006,https://pubmed.ncbi.nlm.nih.gov/39951489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,41596254,The Role of Glucose-Dependent Insulinotropic Polypeptide (GIP) in Bone Metabolism.,2026,10.3390/ijms27020600,https://pubmed.ncbi.nlm.nih.gov/41596254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42199348,Modulation of the tumor microenvironment by incretins and glucagon: Metabolic and immune mechanisms (Review).,2026,10.3892/etm.2026.13178,https://pubmed.ncbi.nlm.nih.gov/42199348/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42728528,The Expanding Role of GLP-1 Receptor Agonists and Dual GIP/GLP-1 Agonists in Dermatology: From Immunometabolism to Clinical Practice.,2026,10.1007/s13555-026-01916-6,https://pubmed.ncbi.nlm.nih.gov/42728528/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42624955,"GLP-1 and dual GIP/GLP-1 receptor agonists' psychopharmacology and putative neuropsychiatric associated effects: a Bradford Hill-informed, systematic, evaluation.",2026,10.1007/s11920-026-01709-w,https://pubmed.ncbi.nlm.nih.gov/42624955/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42857939,Preconception incretin therapy reduces pregnancy and cardiometabolic outcomes in polycystic ovary syndrome.,2026,10.1210/clinem/dgag423,https://pubmed.ncbi.nlm.nih.gov/42857939/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42388369,Biomimetic dual-driven STING nanoagonist orchestrates neoadjuvant mild photo-immunotherapy for fibrosarcoma.,2026,10.1016/j.mtbio.2026.103386,https://pubmed.ncbi.nlm.nih.gov/42388369/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42474400,Mucoadhesive Antioxidant Nanoadjuvant Delivers Enhanced Intranasal Influenza Vaccine Immunogenicity.,2026,10.1021/acsami.6c07805,https://pubmed.ncbi.nlm.nih.gov/42474400/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42819943,Cardiovascular protection beyond glucose lowering: GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonism in contemporary cardiology.,2026,10.3389/fcvm.2026.1926629,https://pubmed.ncbi.nlm.nih.gov/42819943/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42764407,"Preclinical and First-In-Human Evaluation of Ribupatide (HRS9531), a Dual GLP-1/GIP Receptor Agonist.",2026,10.1111/dom.71218,https://pubmed.ncbi.nlm.nih.gov/42764407/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42808923,"Gastrointestinal adverse effects of GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists: A narrative expert review of approved therapies, oral formulations, and pipeline agents.",2026,10.1002/ncp.70180,https://pubmed.ncbi.nlm.nih.gov/42808923/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42791090,Glucagon-Like Peptide-1 Receptor Agonist-Associated Hepatotoxicity.,2026,10.1016/j.clinthera.2026.09.002,https://pubmed.ncbi.nlm.nih.gov/42791090/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42712041,"Safety, Pharmacokinetics and Pharmacodynamics of the GLP-1/GIP/GCG Receptor Agonist UBT251 Injection: A Randomized, Placebo-Controlled Phase 1a/1b Study.",2026,10.1111/dom.71327,https://pubmed.ncbi.nlm.nih.gov/42712041/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42724131,Comparative Efficacy of Promising Targets in the Treatment of Metabolic Dysfunction-associated Steatotic Liver Disease and Steatohepatitis: A Systematic Review and Network Meta-analysis.,2026,10.14218/jcth.2025.00596,https://pubmed.ncbi.nlm.nih.gov/42724131/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42767989,Prior Enteral Feeding and the Interpretation of GIP in the EDEN Trial.,2026,10.1093/ajrccm/aamag493,https://pubmed.ncbi.nlm.nih.gov/42767989/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,42767988,Reply to Wu: Prior Enteral Feeding and the Interpretation of GIP in the EDEN Trial.,2026,10.1093/ajrccm/aamag494,https://pubmed.ncbi.nlm.nih.gov/42767988/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GIP,ENSG00000159224,Unsafe,41902330,Exposure-adjusted safety and efficacy of GLP-I and GLP-1/GIP receptor agonists compared with non-GLP-I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects.,2026,10.1002/bcp.70515,https://pubmed.ncbi.nlm.nih.gov/41902330/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,42577652,Mapping of CELF1-RNA interactions reveals post-transcriptional control of lens development.,2026,10.1093/narmme/ugag037,https://pubmed.ncbi.nlm.nih.gov/42577652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,42827312,Identification of Variants in Two Families With Congenital Cataract by Whole Exome Sequencing.,2026,10.1002/mgg3.70313,https://pubmed.ncbi.nlm.nih.gov/42827312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,42650885,Characterization of Ocular Developmental Disorders in the Israeli Population: Genotype-Phenotype Correlations and Novel Candidate Genes.,2026,10.3390/biom16081219,https://pubmed.ncbi.nlm.nih.gov/42650885/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,40792073,A review on the relationship between the distal 1q21.1 microdeletion and schizophrenia.,2025,10.3389/fgene.2025.1612654,https://pubmed.ncbi.nlm.nih.gov/40792073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,39263294,Genetic association of GJA8 with long-segment Hirschsprung's disease in southern Chinese children.,2024,10.21037/tp-24-153,https://pubmed.ncbi.nlm.nih.gov/39263294/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,40301690,GJA8-associated developmental eye disorders: a new multicentre study highlights mutational hotspots and genotype-phenotype correlations.,2025,10.1038/s41431-025-01843-8,https://pubmed.ncbi.nlm.nih.gov/40301690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,41953648,Exploring the molecular basis of microphthalmia and anophthalmia: Insights from an Egyptian cohort.,2026,,https://pubmed.ncbi.nlm.nih.gov/41953648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,39421685,Dual diagnosis of &lt;i&gt;UQCRFS1&lt;/i&gt;-related mitochondrial complex III deficiency and recessive &lt;i&gt;GJA8&lt;/i&gt;-related cataracts.,2024,10.1016/j.rare.2024.100040,https://pubmed.ncbi.nlm.nih.gov/39421685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,38052906,Association of variants in GJA8 with familial acorea-microphthalmia-cataract syndrome.,2024,10.1038/s41431-023-01503-9,https://pubmed.ncbi.nlm.nih.gov/38052906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,40868138,Genetic Landscape of Congenital Cataracts in a Swiss Cohort: Addressing Diagnostic Oversights in Nance-Horan Syndrome.,2025,10.3390/biomedicines13081883,https://pubmed.ncbi.nlm.nih.gov/40868138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,37294706,Characterization of a Novel Gja8 (Cx50) Mutation in a New Cataract Rat Model.,2023,10.1167/iovs.64.7.18,https://pubmed.ncbi.nlm.nih.gov/37294706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,36915480,CRYAA and GJA8 promote visual development after whisker tactile deprivation.,2023,10.1016/j.heliyon.2023.e13897,https://pubmed.ncbi.nlm.nih.gov/36915480/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,35980487,Identification and functional analysis of two GJA8 variants in Chinese families with eye anomalies.,2022,10.1007/s00438-022-01939-6,https://pubmed.ncbi.nlm.nih.gov/35980487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,40229141,Identification of Genetic Variants Causing Paediatric Cataract in Myanmar.,2025,10.1111/cge.14755,https://pubmed.ncbi.nlm.nih.gov/40229141/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,37680296,Identification of a Missense Mutation in GJA8 Gene in an Iranian Family with Autosomal Dominant Congenital Cataract.,2023,10.4103/joco.joco_2_22,https://pubmed.ncbi.nlm.nih.gov/37680296/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,35726576,Identification of novel cis-mutations in the GJA8 gene in a 3-generation Iranian family with autosomal dominant congenital nuclear cataract.,2022,10.1080/13816810.2022.2089363,https://pubmed.ncbi.nlm.nih.gov/35726576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,37651414,Potential of GJA8 gene variants in predicting age-related cataract: A comparison of supervised machine learning methods.,2023,10.1371/journal.pone.0286243,https://pubmed.ncbi.nlm.nih.gov/37651414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,41822754,Genetic analysis and clinical characteristics of sporadic and familial congenital cataracts in southern Chinese families.,2026,10.3389/fgene.2026.1744173,https://pubmed.ncbi.nlm.nih.gov/41822754/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,36359912,Generation of Lens Progenitor Cells and Lentoid Bodies from Pluripotent Stem Cells: Novel Tools for Human Lens Development and Ocular Disease Etiology.,2022,10.3390/cells11213516,https://pubmed.ncbi.nlm.nih.gov/36359912/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,35223995,Mutations of CX46/CX50 and Cataract Development.,2022,10.3389/fmolb.2022.842399,https://pubmed.ncbi.nlm.nih.gov/35223995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,26912477,CRISPR/Cas9-mediated GJA8 knockout in rabbits recapitulates human congenital cataracts.,2016,10.1038/srep22024,https://pubmed.ncbi.nlm.nih.gov/26912477/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,35011756,First Results from the Prospective German Registry for Childhood Glaucoma: Phenotype-Genotype Association.,2021,10.3390/jcm11010016,https://pubmed.ncbi.nlm.nih.gov/35011756/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,30991053,Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia.,2019,10.1016/j.exer.2019.03.024,https://pubmed.ncbi.nlm.nih.gov/30991053/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,24281366,"Exome sequencing in developmental eye disease leads to identification of causal variants in GJA8, CRYGC, PAX6 and CYP1B1.",2014,10.1038/ejhg.2013.268,https://pubmed.ncbi.nlm.nih.gov/24281366/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,22553694,Epidemiology and molecular genetics of congenital cataracts.,2011,10.3980/j.issn.2222-3959.2011.04.20,https://pubmed.ncbi.nlm.nih.gov/22553694/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,27871290,Heterozygous connexin 50 mutation affects metabolic syndrome attributes in spontaneously hypertensive rat.,2016,10.1186/s12944-016-0376-3,https://pubmed.ncbi.nlm.nih.gov/27871290/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,22669729,A missense mutation in CRYGD linked with autosomal dominant congenital cataract of aculeiform type.,2012,10.1007/s11010-012-1355-2,https://pubmed.ncbi.nlm.nih.gov/22669729/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,23508780,"Whole exome sequencing in dominant cataract identifies a new causative factor, CRYBA2, and a variety of novel alleles in known genes.",2013,10.1007/s00439-013-1289-0,https://pubmed.ncbi.nlm.nih.gov/23508780/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GJA8,ENSG00000121634,Unsafe,19756179,"The GJA8 allele encoding CX50I247M is a rare polymorphism, not a cataract-causing mutation.",2009,,https://pubmed.ncbi.nlm.nih.gov/19756179/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GKAP1,ENSG00000165113,Unsafe,42790802,Protective effects of sarcopenia-related traits on spinal degenerative diseases: A large prospective cohort study.,2026,10.1016/j.bone.2026.118113,https://pubmed.ncbi.nlm.nih.gov/42790802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GKAP1,ENSG00000165113,Unsafe,33820494,"Discovery of a rare GKAP1-NTRK2 fusion in a pediatric low-grade glioma, leading to targeted treatment with TRK-inhibitor larotrectinib.",2021,10.1080/15384047.2021.1899573,https://pubmed.ncbi.nlm.nih.gov/33820494/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GKAP1,ENSG00000165113,Unsafe,39014476,NTRK-fused central nervous system tumours: clinicopathological and genetic insights and response to TRK inhibitors.,2024,10.1186/s40478-024-01798-9,https://pubmed.ncbi.nlm.nih.gov/39014476/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GKAP1,ENSG00000165113,Unsafe,31318116,Functional role of GKAP1 in the regulation of male germ cell spontaneous apoptosis and sperm number.,2019,10.1002/mrd.23236,https://pubmed.ncbi.nlm.nih.gov/31318116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GKAP1,ENSG00000165113,Unsafe,37509153,Exome Survey and Candidate Gene Re-Sequencing Identifies Novel Exstrophy Candidate Genes and Implicates LZTR1 in Disease Formation.,2023,10.3390/biom13071117,https://pubmed.ncbi.nlm.nih.gov/37509153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GKAP1,ENSG00000165113,Unsafe,32175184,A preliminary study of the effect of a high-salt diet on transcriptome dynamics in rat hypothalamic forebrain and brainstem cardiovascular control centers.,2020,10.7717/peerj.8528,https://pubmed.ncbi.nlm.nih.gov/32175184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GKAP1,ENSG00000165113,Unsafe,25586176,Tumor necrosis factor (TNF)-α-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Iα causes insulin resistance in 3T3-L1 adipocytes.,2015,10.1074/jbc.m114.624759,https://pubmed.ncbi.nlm.nih.gov/25586176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GKAP1,ENSG00000165113,Unsafe,30476680,Characterization of acute myeloid leukemia with del(9q) - Impact of the genes in the minimally deleted region.,2019,10.1016/j.leukres.2018.11.007,https://pubmed.ncbi.nlm.nih.gov/30476680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GKAP1,ENSG00000165113,Unsafe,10671526,Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha.,2000,10.1074/jbc.275.7.4897,https://pubmed.ncbi.nlm.nih.gov/10671526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GKAP1,ENSG00000165113,Unsafe,28165652,Candidate susceptibility variants for esophageal squamous cell carcinoma.,2017,10.1002/gcc.22448,https://pubmed.ncbi.nlm.nih.gov/28165652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GKAP1,ENSG00000165113,Unsafe,16015647,Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia.,2005,10.1002/gcc.20236,https://pubmed.ncbi.nlm.nih.gov/16015647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GKAP1,ENSG00000165113,Unsafe,15028281,Quantitative analysis of the cardiac fibroblast transcriptome-implications for NO/cGMP signaling.,2004,10.1016/j.ygeno.2003.10.002,https://pubmed.ncbi.nlm.nih.gov/15028281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLIPR1L2,ENSG00000180481,Unsafe,41233666,Exploring the mediating role of potential therapeutic genes in the pathogenesis of hypopituitarism through the metabolites from a genomic perspective.,2025,10.1007/s00335-025-10169-1,https://pubmed.ncbi.nlm.nih.gov/41233666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLIPR1L2,ENSG00000180481,Unsafe,29299071,Lung function discordance in monozygotic twins and associated differences in blood DNA methylation.,2017,10.1186/s13148-017-0427-2,https://pubmed.ncbi.nlm.nih.gov/29299071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLIPR1L2,ENSG00000180481,Unsafe,16714093,"Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster.",2006,10.1016/j.ygeno.2006.03.021,https://pubmed.ncbi.nlm.nih.gov/16714093/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLIPR1L2,ENSG00000180481,Unsafe,20219979,"Glioma pathogenesis-related 1-like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte binding.",2010,10.1210/en.2009-1255,https://pubmed.ncbi.nlm.nih.gov/20219979/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,42737479,Molecular and Cellular Mechanisms of Synaptogenesis and Synaptic Refinement During Cerebellar Circuit Formation.,2026,10.3390/ijms27177576,https://pubmed.ncbi.nlm.nih.gov/42737479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,42358604,Transsynaptic complex dysfunction in the hippocampus of Alzheimer's disease patients.,2026,10.3389/fnagi.2026.1837327,https://pubmed.ncbi.nlm.nih.gov/42358604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,42270762,GluD1 is localized at cholinergic synapses and is an acetylcholine receptor.,2026,10.1038/s41380-026-03675-4,https://pubmed.ncbi.nlm.nih.gov/42270762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,38791334,Evolution of Glutamate Metabolism via GLUD2 Enhances Lactate-Dependent Synaptic Plasticity and Complex Cognition.,2024,10.3390/ijms25105297,https://pubmed.ncbi.nlm.nih.gov/38791334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,38020911,A comparative analysis of fruit fly and human glutamate dehydrogenases in Drosophila melanogaster sperm development.,2023,10.3389/fcell.2023.1281487,https://pubmed.ncbi.nlm.nih.gov/38020911/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,38673928,"Evolutionary Changes in Primate Glutamate Dehydrogenases 1 and 2 Influence the Protein Regulation by Ligands, Targeting and Posttranslational Modifications.",2024,10.3390/ijms25084341,https://pubmed.ncbi.nlm.nih.gov/38673928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,40957579,Delta-type glutamate receptors are ligand-gated ion channels.,2025,10.1038/s41586-025-09610-x,https://pubmed.ncbi.nlm.nih.gov/40957579/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,42687380,AAV-mediated CBLN1 replacement rescues hereditary ataxia caused by bi-allelic CBLN1 variants.,2026,10.1016/j.ymthe.2026.09.003,https://pubmed.ncbi.nlm.nih.gov/42687380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,39890638,D-Serine disrupts Cbln1 and GluD1 interaction and affects Cbln1-dependent synaptic effects and nocifensive responses in the central amygdala.,2025,10.1007/s00018-024-05554-z,https://pubmed.ncbi.nlm.nih.gov/39890638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,38333701,Glutamate-specific gene linked to human brain evolution enhances synaptic plasticity and cognitive processes.,2024,10.1016/j.isci.2024.108821,https://pubmed.ncbi.nlm.nih.gov/38333701/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,39052831,Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.,2024,10.1073/pnas.2406655121,https://pubmed.ncbi.nlm.nih.gov/39052831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,40824568,Glutamate delta-1 receptors regulate a tonic excitatory conductance in the mouse bed nucleus of the stria terminalis and influence neuronal function.,2026,10.1007/s00213-025-06876-x,https://pubmed.ncbi.nlm.nih.gov/40824568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,42605218,Ion binding sites and intermediate domain closure induced by D-serine in the GluD1 ligand-binding domain.,2026,10.1111/febs.70702,https://pubmed.ncbi.nlm.nih.gov/42605218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,38658571,Functional synergy of a human-specific and an ape-specific metabolic regulator in human neocortex development.,2024,10.1038/s41467-024-47437-8,https://pubmed.ncbi.nlm.nih.gov/38658571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,39806458,Phosphatidylinositol promoted the proliferation and invasion of pituitary adenoma cells by regulating POU1F1 expression.,2025,10.1186/s40170-024-00372-0,https://pubmed.ncbi.nlm.nih.gov/39806458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,41287930,Age-Progressive Synaptic and Axonal Dysregulation Induced by Purkinje Cell-Targeted AAV Expression of SCA14 PKCγ in Mice.,2025,10.1111/jnc.70305,https://pubmed.ncbi.nlm.nih.gov/41287930/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,37944084,"Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants.",2024,10.1093/hmg/ddad188,https://pubmed.ncbi.nlm.nih.gov/37944084/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,38614076,Toward clinical exomes in diagnostics and management of male infertility.,2024,10.1016/j.ajhg.2024.03.013,https://pubmed.ncbi.nlm.nih.gov/38614076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,33443132,Absence of GluD2 Antibodies in Patients With Opsoclonus-Myoclonus Syndrome.,2021,10.1212/wnl.0000000000011410,https://pubmed.ncbi.nlm.nih.gov/33443132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,37488606,C1ql1-Bai3 signaling is necessary for climbing fiber synapse formation in mature Purkinje cells in coordination with neuronal activity.,2023,10.1186/s13041-023-01048-4,https://pubmed.ncbi.nlm.nih.gov/37488606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,39875978,Alzheimer's disease: an integrative bioinformatics and machine learning analysis reveals glutamine metabolism-associated gene biomarkers.,2025,10.1186/s40360-025-00852-z,https://pubmed.ncbi.nlm.nih.gov/39875978/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,39684939,"Characterising a Novel Therapeutic Target for Psoriasis, TYK2, Using Functional Genomics.",2024,10.3390/ijms252313229,https://pubmed.ncbi.nlm.nih.gov/39684939/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,38150033,Genetic Discrimination of Grade 3 and Grade 4 Gliomas by Artificial Neural Network.,2023,10.1007/s10571-023-01448-z,https://pubmed.ncbi.nlm.nih.gov/38150033/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,37268894,Bioinformatics and experimental analyses of glutamate receptor and its targets genes in myocardial and cerebral ischemia.,2023,10.1186/s12864-023-09408-z,https://pubmed.ncbi.nlm.nih.gov/37268894/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,36692643,Metabolic heterogeneity in early-stage lung adenocarcinoma revealed by RNA-seq and scRNA-seq.,2023,10.1007/s12094-023-03082-z,https://pubmed.ncbi.nlm.nih.gov/36692643/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,30045961,Glutamate receptor δ2 serum antibodies in pediatric opsoclonus myoclonus ataxia syndrome.,2018,10.1212/wnl.0000000000006035,https://pubmed.ncbi.nlm.nih.gov/30045961/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,27820843,Involvement of GluD2 in Fear-Conditioned Bradycardia in Mice.,2016,10.1371/journal.pone.0166144,https://pubmed.ncbi.nlm.nih.gov/27820843/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,27118840,Mice carrying a human GLUD2 gene recapitulate aspects of human transcriptome and metabolome development.,2016,10.1073/pnas.1519261113,https://pubmed.ncbi.nlm.nih.gov/27118840/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,35304260,Glutamate delta 1 receptor regulates autophagy mechanisms and affects excitatory synapse maturation in the somatosensory cortex.,2022,10.1016/j.phrs.2022.106144,https://pubmed.ncbi.nlm.nih.gov/35304260/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,32917661,Ammonia inhibits energy metabolism in astrocytes in a rapid and glutamate dehydrogenase 2-dependent manner.,2020,10.1242/dmm.047134,https://pubmed.ncbi.nlm.nih.gov/32917661/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,34158618,Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors.,2021,10.1038/s41380-021-01187-x,https://pubmed.ncbi.nlm.nih.gov/34158618/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,25225364,Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma.,2014,10.1073/pnas.1409653111,https://pubmed.ncbi.nlm.nih.gov/25225364/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,32727118,Upregulation of GLS1 Isoforms KGA and GAC Facilitates Mitochondrial Metabolism and Cell Proliferation in Epstein-Barr Virus Infected Cells.,2020,10.3390/v12080811,https://pubmed.ncbi.nlm.nih.gov/32727118/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,23431139,The δ2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites.,2013,10.1073/pnas.1218380110,https://pubmed.ncbi.nlm.nih.gov/23431139/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,19683518,Glutamate dehydrogenase activity in lymphocytes of B-cell chronic lymphocytic leukaemia patients.,2009,10.1016/j.clinbiochem.2009.08.003,https://pubmed.ncbi.nlm.nih.gov/19683518/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,19826450,Gain-of-function variant in GLUD2 glutamate dehydrogenase modifies Parkinson's disease onset.,2010,10.1038/ejhg.2009.179,https://pubmed.ncbi.nlm.nih.gov/19826450/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,27903723,"Cerebellar Shank2 Regulates Excitatory Synapse Density, Motor Coordination, and Specific Repetitive and Anxiety-Like Behaviors.",2016,10.1523/jneurosci.1849-16.2016,https://pubmed.ncbi.nlm.nih.gov/27903723/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GLUD2,ENSG00000182890,Unsafe,8207021,Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene.,1994,10.1016/s0021-9258(19)89484-x,https://pubmed.ncbi.nlm.nih.gov/8207021/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMCL1,ENSG00000087338,Unsafe,41553759,GMCL1 controls 53BP1 stability and modulates taxane sensitivity.,2026,10.7554/elife.106730,https://pubmed.ncbi.nlm.nih.gov/41553759/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMCL1,ENSG00000087338,Unsafe,42897663,"Exome-wide association study reveals common and rare coding variants shaping chronic pain in 327,642 UK biobank participants.",2026,10.1186/s13073-026-01732-9,https://pubmed.ncbi.nlm.nih.gov/42897663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMCL1,ENSG00000087338,Unsafe,41887696,[Analysis of potential association of alcohol exposure with femoral head osteonecrosis and construction of a diagnostic model using machine learning].,2026,10.12122/j.issn.1673-4254.2026.03.10,https://pubmed.ncbi.nlm.nih.gov/41887696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMCL1,ENSG00000087338,Unsafe,30544396,An in silico analysis of human sperm genes associated with asthenozoospermia and its implication in male infertility.,2018,10.1097/md.0000000000013338,https://pubmed.ncbi.nlm.nih.gov/30544396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMCL1,ENSG00000087338,Unsafe,35395503,Epigenome-wide association analyses of active injection drug use.,2022,10.1016/j.drugalcdep.2022.109431,https://pubmed.ncbi.nlm.nih.gov/35395503/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMCL1,ENSG00000087338,Unsafe,36048845,Exome sequencing and functional analyses revealed CETN1 variants leads to impaired cell division and male fertility.,2023,10.1093/hmg/ddac216,https://pubmed.ncbi.nlm.nih.gov/36048845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMCL1,ENSG00000087338,Unsafe,32728162,Altered mechanisms of genital development identified through integration of DNA methylation and genomic measures in hypospadias.,2020,10.1038/s41598-020-69725-1,https://pubmed.ncbi.nlm.nih.gov/32728162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMCL1,ENSG00000087338,Unsafe,30967136,Novel potential causative genes in carotid paragangliomas.,2019,10.1186/s12881-019-0770-6,https://pubmed.ncbi.nlm.nih.gov/30967136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMCL1,ENSG00000087338,Unsafe,20432501,1q12 chromosome translocations form aberrant heterochromatic foci associated with changes in nuclear architecture and gene expression in B cell lymphoma.,2010,10.1002/emmm.201000067,https://pubmed.ncbi.nlm.nih.gov/20432501/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMCL1,ENSG00000087338,Unsafe,17010969,Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages.,2006,10.1016/j.yexcr.2006.07.019,https://pubmed.ncbi.nlm.nih.gov/17010969/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMCL2,ENSG00000244234,Unsafe,41553759,GMCL1 controls 53BP1 stability and modulates taxane sensitivity.,2026,10.7554/elife.106730,https://pubmed.ncbi.nlm.nih.gov/41553759/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMCL2,ENSG00000244234,Unsafe,16201836,Emergence of young human genes after a burst of retroposition in primates.,2005,10.1371/journal.pbio.0030357,https://pubmed.ncbi.nlm.nih.gov/16201836/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,42488677,Dysregulated lipid metabolites GML and GMO were associated with cytotoxic T cell function and serve as biomarkers for acute pulmonary embolism.,2026,10.3389/fimmu.2026.1756977,https://pubmed.ncbi.nlm.nih.gov/42488677/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,42291204,Pathological extracellular matrix changes in decellularized normal appearing gray matter and subpial multiple sclerosis lesions.,2026,10.1016/j.isci.2026.116020,https://pubmed.ncbi.nlm.nih.gov/42291204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,42792208,Glycerol Monolaurate Supplementation in Extruded Diets Enhances Immune Function and Antioxidant Capacity and Alters the Gut Microbiota and Fecal Metabolome in Cats.,2026,10.3390/antiox15091169,https://pubmed.ncbi.nlm.nih.gov/42792208/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,42278009,"Effects of Dietary Glycerol Monolaurate on Growth Performance, Bile Acid Metabolism, and Intestinal Health in Asian Swamp Eel (&lt;i&gt;Monopterus albus&lt;/i&gt;).",2026,10.3390/ani16111575,https://pubmed.ncbi.nlm.nih.gov/42278009/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,42357770,Dietary Glycerol Monolaurate Enhances Growth and Immune Function in Calves via Hepatic Immunometabolic Reprogramming.,2026,10.3390/vetsci13060572,https://pubmed.ncbi.nlm.nih.gov/42357770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,42300754,Antibacterial activity of glycerol monolaurate formulated in petrolatum.,2026,10.1128/spectrum.00613-26,https://pubmed.ncbi.nlm.nih.gov/42300754/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,41876946,Lauric Acid and Glycerol Monolaurate Inhibit the Activity of Cyprinid Herpesvirus 2 and Enhance Host Immune Reaction.,2026,10.1111/jfd.70174,https://pubmed.ncbi.nlm.nih.gov/41876946/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,41998759,Glycerol monolaurate attenuates necrotic enteritis in broilers by improving gut-liver health and remodeling the gut microbiota.,2026,10.1186/s40104-026-01388-w,https://pubmed.ncbi.nlm.nih.gov/41998759/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,42866580,"A tributyrin-monolaurin complex protects piglets against PEDV infection via viral inhibition, lipid metabolism restoration, and microbiota modulation.",2026,10.1016/j.aninu.2026.04.006,https://pubmed.ncbi.nlm.nih.gov/42866580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,42645088,Beyond Infection: Mitochondrial Reprogramming and Immunometabolic Adaptation in &lt;i&gt;Helicobacter pylori&lt;/i&gt;-Associated Gastric MALT Lymphoma.,2026,10.3390/diseases14080280,https://pubmed.ncbi.nlm.nih.gov/42645088/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,42351767,Unveiling the Importance of the Expression of LY6/UPAR Gene Family Members in Urothelial Carcinoma of the Urinary Bladder.,2026,10.3390/biomedicines14061339,https://pubmed.ncbi.nlm.nih.gov/42351767/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,41512667,Research note: Exploring the effects of glycerol monolaurate on lipid metabolism in young broilers based on molecular dynamics simulation and 16S rRNA analysis.,2026,10.1016/j.psj.2026.106383,https://pubmed.ncbi.nlm.nih.gov/41512667/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,41764300,Beyond RBD: covert REM sleep abnormalities in Parkinson's disease.,2026,10.1038/s41531-026-01295-x,https://pubmed.ncbi.nlm.nih.gov/41764300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,41574689,Potent Inhibitory Effects of Lauric Acid and Glycerol Monolaurate Against CyHV-2 and the Viral Envelope.,2026,10.1111/jfd.70129,https://pubmed.ncbi.nlm.nih.gov/41574689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,40722887,Dietary Glyceryl Monolaurate Supplementation During Pregnancy Enhances Fetal Intrauterine Development and Antioxidant Capacity in Sows via Microbiota Modulation.,2025,10.3390/antiox14070783,https://pubmed.ncbi.nlm.nih.gov/40722887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,40794302,Dietary glycerol monolaurate mitigates heat stress-induced disruption of intestinal homeostasis and hepatic lipid metabolism in laying hens.,2025,10.1007/s44154-025-00243-8,https://pubmed.ncbi.nlm.nih.gov/40794302/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,41265486,Optimal ratio of laurate and butyrate from glyceride forms improves nutrient digestibility and health in weaned piglets.,2026,10.5713/ab.250645,https://pubmed.ncbi.nlm.nih.gov/41265486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,41301971,"Dietary Glycerol Monolaurate Effect on Growth Performance, Intestinal Barrier Function, and Gut Microbiota in Weaned Piglets Challenged by Lipopolysaccharide.",2025,10.3390/ani15223263,https://pubmed.ncbi.nlm.nih.gov/41301971/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,42536216,Effect of vestibular depth on root coverage predictability in Cairo recession type 2 labial gingival recession treated with minimally invasive technique using connective tissue graft: Prospective cohort study.,2026,10.1007/s00784-026-07055-8,https://pubmed.ncbi.nlm.nih.gov/42536216/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,41964566,Accelerating Excited-State Calculations of Large Systems with Restricted Boltzmann Machines.,2026,10.1021/acs.jctc.6c00168,https://pubmed.ncbi.nlm.nih.gov/41964566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,41829146,Strategically Designed Coaxial Electrospun Nanofibers of Polylactic Acid/Glycerol Monolaurate Hydroxypropyl-&lt;i&gt;γ&lt;/i&gt;-Cyclodextrin Inclusion Compound with Sustained Release for Active Food Packaging.,2026,10.3390/foods15050872,https://pubmed.ncbi.nlm.nih.gov/41829146/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,41036846,"Antifungal, antibacterial, and anti-inflammatory activity of glycerol dithionomonolaurate, an analog of glycerol monolaurate.",2025,10.1128/msphere.00318-25,https://pubmed.ncbi.nlm.nih.gov/41036846/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,42605015,Selective Enzymatic Synthesis of Glucose Fatty Acid Esters in a Choline Chloride-Glucose Reactive Deep Eutectic Solvent.,2026,10.1002/cssc.70963,https://pubmed.ncbi.nlm.nih.gov/42605015/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,42426686,Efficacy of Leukocyte and Platelet-Rich Fibrin (L-PRF) as an adjunct to Open Flap Debridement (OFD) in periodontal intrabony defects: a systematic review and meta-analysis.,2026,10.1186/s12903-026-09163-z,https://pubmed.ncbi.nlm.nih.gov/42426686/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,38607375,Genotoxicity and safety pharmacology of the rVSVInd(GML)-mspSGtc vaccine against SARS-CoV-2 in Sprague-Dawley rats and Beagle dogs.,2024,10.1007/s00204-024-03746-x,https://pubmed.ncbi.nlm.nih.gov/38607375/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,42522415,Vitamins A- and C-augmented platelet-rich fibrin in periodontal intraosseous defects: A randomized clinical trial.,2026,10.1002/jper.70173,https://pubmed.ncbi.nlm.nih.gov/42522415/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,37821316,Nonclinical safety assessment and immunogenicity of rVSVInd(GML)-mspSGtc vaccine for SARS-CoV-2 in rabbits.,2023,10.1016/j.vaccine.2023.10.008,https://pubmed.ncbi.nlm.nih.gov/37821316/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GML,ENSG00000104499,Unsafe,41716843,"Dietary supplementation of glycerol monolaurate improves growth performance, meat quality, and gut microbiota in black pigs.",2026,10.1016/j.aninu.2025.09.005,https://pubmed.ncbi.nlm.nih.gov/41716843/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,41193599,Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids.,2026,10.1038/s44319-025-00621-3,https://pubmed.ncbi.nlm.nih.gov/41193599/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,40223815,Genome-Wide Association Study of Grain Manganese Content in Bread Wheat (&lt;i&gt;Triticum aestivum&lt;/i&gt; L.) Under Four Environments.,2025,10.1002/fsn3.70170,https://pubmed.ncbi.nlm.nih.gov/40223815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,41381974,Deep neural networks and genome-wide associations reveal the polygenic architecture of local brain aging.,2026,10.1007/s11357-025-02046-1,https://pubmed.ncbi.nlm.nih.gov/41381974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,42014397,"GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy.",2026,10.1038/s41467-026-71682-8,https://pubmed.ncbi.nlm.nih.gov/42014397/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,39468302,Ependymal cell lineage reprogramming as a potential therapeutic intervention for hydrocephalus.,2024,10.1038/s44321-024-00156-5,https://pubmed.ncbi.nlm.nih.gov/39468302/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,41413096,Zmynd10 drives centriole biogenesis and multiciliogenesis through the transcriptional regulation of E2f4.,2025,10.1038/s41598-025-27956-0,https://pubmed.ncbi.nlm.nih.gov/41413096/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,40207459,Differential contribution of P73+ Cajal-Retzius cells and Reelin to cortical morphogenesis.,2025,10.1242/dev.204451,https://pubmed.ncbi.nlm.nih.gov/40207459/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,42686618,Ependymal Cells and Hydrocephalus: Recent Advances in Molecular Mechanisms.,2026,10.1248/bpb.b26-00284,https://pubmed.ncbi.nlm.nih.gov/42686618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,39805841,Genome-wide association study unravels mechanisms of brain glymphatic activity.,2025,10.1038/s41467-024-55706-9,https://pubmed.ncbi.nlm.nih.gov/39805841/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,35322202,Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development.,2022,10.1038/s41418-022-00950-z,https://pubmed.ncbi.nlm.nih.gov/35322202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,42840284,Epigenetic profiling of preterm birth: a dual-tissue methylation patterns using long-read sequencing.,2025,10.3389/freae.2025.1644521,https://pubmed.ncbi.nlm.nih.gov/42840284/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,36932059,GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program.,2023,10.1038/s41419-023-05720-4,https://pubmed.ncbi.nlm.nih.gov/36932059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,37822511,Genome-wide association study of hippocampal blood-oxygen-level-dependent-cerebral blood flow correlation in Chinese Han population.,2023,10.1016/j.isci.2023.108005,https://pubmed.ncbi.nlm.nih.gov/37822511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,36516767,p53/p21 pathway activation contributes to the ependymal fate decision downstream of GemC1.,2022,10.1016/j.celrep.2022.111810,https://pubmed.ncbi.nlm.nih.gov/36516767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,38438384,Genetic architecture of the structural connectome.,2024,10.1038/s41467-024-46023-2,https://pubmed.ncbi.nlm.nih.gov/38438384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,39457408,Nongenetic and Genetic Factors Associated with White Matter Brain Aging: Exposome-Wide and Genome-Wide Association Study.,2024,10.3390/genes15101285,https://pubmed.ncbi.nlm.nih.gov/39457408/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,39895399,Motile cilia: Key developmental and functional roles in reproductive systems.,2025,10.1111/andr.70007,https://pubmed.ncbi.nlm.nih.gov/39895399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,39662468,Actin-based deformations of the nucleus control mouse multiciliated ependymal cell differentiation.,2025,10.1016/j.devcel.2024.11.008,https://pubmed.ncbi.nlm.nih.gov/39662468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,37321213,Repurposing of the multiciliation gene regulatory network in fate specification of Cajal-Retzius neurons.,2023,10.1016/j.devcel.2023.05.011,https://pubmed.ncbi.nlm.nih.gov/37321213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,40420860,Mapping of the QTLs governing grain nutrients in wheat (&lt;i&gt;Triticum aestivum&lt;/i&gt; L.) under nitrogen treatment using high-density SNP markers.,2025,10.3389/fpls.2025.1553525,https://pubmed.ncbi.nlm.nih.gov/40420860/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,32734627,Mucosal-associated invariant T (MAIT) cells are activated in the gastrointestinal tissue of patients with combination ipilimumab and nivolumab therapy-related colitis in a pathology distinct from ulcerative colitis.,2020,10.1111/cei.13502,https://pubmed.ncbi.nlm.nih.gov/32734627/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,36066633,Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers.,2022,10.1007/s00401-022-02454-z,https://pubmed.ncbi.nlm.nih.gov/36066633/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,37539664,Genome-Wide Meta-Analysis of Cerebrospinal Fluid Biomarkers in Alzheimer's Disease and Parkinson's Disease Cohorts.,2023,10.1002/mds.29511,https://pubmed.ncbi.nlm.nih.gov/37539664/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,34610312,Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain.,2021,10.1016/j.celrep.2021.109775,https://pubmed.ncbi.nlm.nih.gov/34610312/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,35346299,Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease.,2022,10.1186/s13024-022-00521-3,https://pubmed.ncbi.nlm.nih.gov/35346299/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,33223526,Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset.,2020,10.1038/s41398-020-01074-z,https://pubmed.ncbi.nlm.nih.gov/33223526/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,29967939,Sex-specific genetic predictors of Alzheimer's disease biomarkers.,2018,10.1007/s00401-018-1881-4,https://pubmed.ncbi.nlm.nih.gov/29967939/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,21344959,Difficulties with recruiting into neurosurgical clinical trials: the Surgical Trial in IntraCerebral Haemorrhage II as an example.,2011,10.3109/02688697.2010.539718,https://pubmed.ncbi.nlm.nih.gov/21344959/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GMNC,ENSG00000205835,Unsafe,23562540,GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.,2013,10.1016/j.neuron.2013.02.026,https://pubmed.ncbi.nlm.nih.gov/23562540/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,41387123,The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal&lt;sup&gt;+/-&lt;/sup&gt; Mouse Model of DYT25 Dystonia.,2026,10.1002/advs.202512942,https://pubmed.ncbi.nlm.nih.gov/41387123/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,41674994,GNAL-driven calcium signaling reshapes the spatiotemporal immune landscape in ER&lt;sup&gt;+&lt;/sup&gt; breast cancer: causal insights and prognostic implications.,2026,10.21037/tcr-2025-1796,https://pubmed.ncbi.nlm.nih.gov/41674994/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,41632233,Long-term efficiency of pallidal DBS and the role of Levodopa treatment in DYT-GNAL and 18p deletion syndrome associated dystonia: an observational study and review of literature.,2026,10.1007/s00702-026-03109-z,https://pubmed.ncbi.nlm.nih.gov/41632233/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,42782347,"GNAL-associated dystonia: clinical spectrum, genetic features, and genotype-phenotype correlations.",2026,10.1007/s00702-026-03298-7,https://pubmed.ncbi.nlm.nih.gov/42782347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,42710563,Cu disrupts the olfacto-retinal centrifugal pathway and mediates reduced feeding-related behavior in zebrafish (Danio rerio).,2026,10.1016/j.envpol.2026.129126,https://pubmed.ncbi.nlm.nih.gov/42710563/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,41400152,"Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia.",2026,10.1002/acn3.70285,https://pubmed.ncbi.nlm.nih.gov/41400152/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,38960060,Neuron specific quantitation of Gα&lt;sub&gt;olf&lt;/sub&gt; expression and signaling in murine brain tissue.,2024,10.1016/j.brainres.2024.149105,https://pubmed.ncbi.nlm.nih.gov/38960060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,38686055,Multi-cohort comprehensive analysis unveiling the clinical value and therapeutic effect of GNAL in glioma.,2024,10.32604/or.2024.045769,https://pubmed.ncbi.nlm.nih.gov/38686055/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,40902679,Characterization of mice with cell type-specific Gnal loss of function provides insights on GNAL-linked dystonia.,2025,10.1016/j.nbd.2025.107071,https://pubmed.ncbi.nlm.nih.gov/40902679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,38182074,Loss-of-function of GNAL dystonia gene impairs striatal dopamine receptors-mediated adenylyl cyclase/ cyclic AMP signaling pathway.,2024,10.1016/j.nbd.2024.106403,https://pubmed.ncbi.nlm.nih.gov/38182074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,41496077,Mendelian randomization identifies circulating miRNAs as causal mediators of gastric cancer susceptibility and survival outcomes.,2026,10.1097/md.0000000000046833,https://pubmed.ncbi.nlm.nih.gov/41496077/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,41491140,4D-DIA proteomics analysis revealed the network pharmacological mechanism of Astragaloside IV for the treatment of diabetic retinopathy.,2026,10.1080/00498254.2025.2612600,https://pubmed.ncbi.nlm.nih.gov/41491140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,42194935,Clinical Phenotype Comparison in Polish Patient Cohorts with and Without Molecular Diagnosis of Dystonia.,2026,10.3390/jcm15103975,https://pubmed.ncbi.nlm.nih.gov/42194935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,42610089,Effects of glucocorticoid on cardiac chronotropic responsiveness in cirrhotic rats: A possible role for dopamine receptors.,2026,10.22038/ijbms.2026.91247.19739,https://pubmed.ncbi.nlm.nih.gov/42610089/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,38736233,Tremulous Dystonia Due to GNAL Haploinsufficiency Caused by 18p Deletion Syndrome.,2024,10.14802/jmd.24080,https://pubmed.ncbi.nlm.nih.gov/38736233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,38850091,"Pediatric Onset of Generalized Dystonia, Cognitive Impairment, and Dysmorphic Features in a Patient Carrying Compound Heterozygous GNAL Mutations.",2024,10.1002/mdc3.14124,https://pubmed.ncbi.nlm.nih.gov/38850091/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,40806237,Large-Scale Profiling of Coding and Long Noncoding Transcriptomes in the Hippocampus of Mice Acutely Exposed to Vaporized CBD or THC.,2025,10.3390/ijms26157106,https://pubmed.ncbi.nlm.nih.gov/40806237/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,42308683,"The genetic landscape of childhood-onset dystonia in a nationwide Turkish cohort: Clinical spectrum, molecular diagnostics, and therapeutic implications.",2026,10.1016/j.ejpn.2026.06.003,https://pubmed.ncbi.nlm.nih.gov/42308683/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,39387560,An integrative analysis based on multiple cell death patterns identifies an immunosuppressive subtype and establishes a prognostic signature in lower-grade glioma.,2024,10.1080/07853890.2024.2412831,https://pubmed.ncbi.nlm.nih.gov/39387560/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,42063640,Comparative Analysis Reveals the Adaptive Evolution of Olfactory System in the Swamp Eel (&lt;i&gt;Monopterus albus&lt;/i&gt;) Based on the Chromosome-Level Genome.,2026,10.1002/ece3.73586,https://pubmed.ncbi.nlm.nih.gov/42063640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,36937704,Autoantibodies involved in primary and secondary adrenal insufficiency following treatment with immune checkpoint inhibitors.,2023,10.1016/j.iotech.2023.100374,https://pubmed.ncbi.nlm.nih.gov/36937704/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,38612382,Genetic Update and Treatment for Dystonia.,2024,10.3390/ijms25073571,https://pubmed.ncbi.nlm.nih.gov/38612382/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,35699413,Functional abnormalities in the cerebello-thalamic pathways in a mouse model of DYT25 dystonia.,2022,10.7554/elife.79135,https://pubmed.ncbi.nlm.nih.gov/35699413/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,31158945,The Effect of Globus Pallidus Interna Deep Brain Stimulation on a Dystonia Patient with the GNAL Mutation Compared to Patients with DYT1 and DYT6.,2019,10.14802/jmd.19006,https://pubmed.ncbi.nlm.nih.gov/31158945/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,37008785,"Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum of Shank3 mutant mice.",2023,10.3389/fnmol.2023.1139118,https://pubmed.ncbi.nlm.nih.gov/37008785/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,31611368,Autoimmune antibodies correlate with immune checkpoint therapy-induced toxicities.,2019,10.1073/pnas.1908079116,https://pubmed.ncbi.nlm.nih.gov/31611368/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,28546310,Heterozygous Gnal Mice Are a Novel Animal Model with Which to Study Dystonia Pathophysiology.,2017,10.1523/jneurosci.1529-16.2017,https://pubmed.ncbi.nlm.nih.gov/28546310/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,27222887,Homozygous GNAL mutation associated with familial childhood-onset generalized dystonia.,2016,10.1212/nxg.0000000000000078,https://pubmed.ncbi.nlm.nih.gov/27222887/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,33577922,Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression.,2021,10.1016/j.nbd.2021.105289,https://pubmed.ncbi.nlm.nih.gov/33577922/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,27123488,Clinical and genetic features of cervical dystonia in a large multicenter cohort.,2016,10.1212/nxg.0000000000000069,https://pubmed.ncbi.nlm.nih.gov/27123488/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAL,ENSG00000141404,Unsafe,8243272,Human G(olf) alpha: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous system.,1993,10.1210/endo.133.6.8243272,https://pubmed.ncbi.nlm.nih.gov/8243272/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,41954843,Autosomal dominant Riggs-type congenital stationary night blindness with fundus sheen and retinal atrophy due to a novel GNAT1 p.Gln200Arg variant.,2026,10.1007/s10633-026-10100-2,https://pubmed.ncbi.nlm.nih.gov/41954843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,42814154,"Photoperiod driven modulation of behavior, gut microbiota, and brain transcriptomics in zebrafish.",2026,10.1007/s00424-026-03214-8,https://pubmed.ncbi.nlm.nih.gov/42814154/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,41107067,"Dysfunction of Unc119, a Transducin-Binding Protein, Leads to Cone-Rod Dystrophy through Activating JAK-Stat and NF-κB Inflammatory Pathways in the Mouse Retina.",2025,10.1523/jneurosci.2245-24.2025,https://pubmed.ncbi.nlm.nih.gov/41107067/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,41707820,"Negative effects of microcystin-LR on larval zebrafish: Focus on visual function, behavior, and circadian rhythm regulation.",2026,10.1016/j.cbpc.2026.110488,https://pubmed.ncbi.nlm.nih.gov/41707820/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,41594868,ORY-1001 Delays Retinal Photoreceptor Degeneration in rd10 Mice by Inhibiting H3K4me2 Demethylation.,2026,10.3390/biology15020132,https://pubmed.ncbi.nlm.nih.gov/41594868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,41353195,"Microstructure and transcriptomics reveal rapid light-induced visual plasticity in the non-obligate cave dweller Oreolalax rhodostigmatus (Megophryidae, Anura).",2025,10.1186/s12864-025-12379-y,https://pubmed.ncbi.nlm.nih.gov/41353195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,41484209,Comprehensive transcriptomic analysis reveals canonical and novel pathways modulated by nanoceria in mammalian retinal degeneration.,2026,10.1038/s41598-025-33260-8,https://pubmed.ncbi.nlm.nih.gov/41484209/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,40943038,"Sakuranetin, A Laxative Component from Peach Leaves and Its Intervention in Metabolism.",2025,10.3390/ijms26178112,https://pubmed.ncbi.nlm.nih.gov/40943038/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,42685483,Transcriptomics reveals the gene expression dynamics during embryonic development of largemouth bass (Micropterus nigricans) at the endogenous nutrition stage.,2026,10.1016/j.cbd.2026.101994,https://pubmed.ncbi.nlm.nih.gov/42685483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,40013354,Monogenic Retinal Diseases Associated With Genes Encoding Phototransduction Proteins: A Review.,2025,10.1111/ceo.14511,https://pubmed.ncbi.nlm.nih.gov/40013354/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,39349166,"The Plastidial Protein Acetyltransferase GNAT1 Forms a Complex With GNAT2, yet Their Interaction Is Dispensable for State Transitions.",2024,10.1016/j.mcpro.2024.100850,https://pubmed.ncbi.nlm.nih.gov/39349166/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,41980279,A comprehensive evaluation of the effects and mechanisms of naringenin on zebrafish embryo development.,2026,10.1016/j.ecoenv.2026.120131,https://pubmed.ncbi.nlm.nih.gov/41980279/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,42161108,Adverse outcome pathway-based analysis of vanillic acid-induced neurodevelopmental toxicity and cellular senescence in zebrafish.,2026,10.1016/j.ecoenv.2026.120287,https://pubmed.ncbi.nlm.nih.gov/42161108/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,41294855,Loss of BAP31 Is Detrimentally Aging Photoreceptors Through ER Stress-Mediated Retinal Degeneration.,2025,10.3390/cells14221802,https://pubmed.ncbi.nlm.nih.gov/41294855/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,41375993,"Identification of Bitter Peptides in &lt;i&gt;Lilium lancifolium&lt;/i&gt; Thunb.; Peptidomics, Computational Simulation and Cellular Functional Assays.",2025,10.3390/foods14234056,https://pubmed.ncbi.nlm.nih.gov/41375993/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,40570846,Photoreceptor degeneration induces homeostatic rewiring of rod bipolar cells.,2025,10.1016/j.cub.2025.05.057,https://pubmed.ncbi.nlm.nih.gov/40570846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,38599212,Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin/β-catenin signaling.,2024,10.1016/j.neuron.2024.03.011,https://pubmed.ncbi.nlm.nih.gov/38599212/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,36605613,Robust visual cortex evoked potentials (VEP) in Gnat1 and Gnat2 knockout mice.,2022,10.3389/fncel.2022.1090037,https://pubmed.ncbi.nlm.nih.gov/36605613/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,35008877,Depletion of Retinal Dopaminergic Activity in a Mouse Model of Rod Dysfunction Exacerbates Experimental Autoimmune Uveoretinitis: A Role for the Gateway Reflex.,2021,10.3390/ijms23010453,https://pubmed.ncbi.nlm.nih.gov/35008877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,39089885,Synchronized Photoactivation of T4K Rhodopsin Causes a Chromophore-Dependent Retinal Degeneration That Is Moderated by Interaction with Phototransduction Cascade Components.,2024,10.1523/jneurosci.0453-24.2024,https://pubmed.ncbi.nlm.nih.gov/39089885/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,39924290,Gibberellic acid (GA) induces developmental toxicity in zebrafish (Danio rerio) embryos via oxidative stress.,2025,10.1016/j.aquatox.2025.107247,https://pubmed.ncbi.nlm.nih.gov/39924290/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,34995633,Antagonistic effects and mechanisms of carbendazim and chlorpyrifos on the neurobehavior of larval zebrafish.,2022,10.1016/j.chemosphere.2022.133522,https://pubmed.ncbi.nlm.nih.gov/34995633/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,32721018,Stimulus-Driven Retinal Intrinsic Signal Optical Imaging in Mouse Demonstrates a Dominant Rod-Driven Component.,2020,10.1167/iovs.61.8.37,https://pubmed.ncbi.nlm.nih.gov/32721018/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,33731211,Maternal antibiotic treatment affects offspring gastric sensing for umami taste and ghrelin regulation in the pig.,2021,10.1186/s40104-021-00557-3,https://pubmed.ncbi.nlm.nih.gov/33731211/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,34099749,Variations in photoreceptor throughput to mouse visual cortex and the unique effects on tuning.,2021,10.1038/s41598-021-90650-4,https://pubmed.ncbi.nlm.nih.gov/34099749/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,30947334,A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness.,2019,10.1167/iovs.19-26560,https://pubmed.ncbi.nlm.nih.gov/30947334/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,30064895,Retained Plasticity and Substantial Recovery of Rod-Mediated Visual Acuity at the Visual Cortex in Blind Adult Mice with Retinal Dystrophy.,2018,10.1016/j.ymthe.2018.07.012,https://pubmed.ncbi.nlm.nih.gov/30064895/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,31978605,Light deprivation reduces the severity of experimental diabetic retinopathy.,2020,10.1016/j.nbd.2020.104754,https://pubmed.ncbi.nlm.nih.gov/31978605/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,28085063,Retinoic Acid Protects and Rescues the Development of Zebrafish Embryonic Retinal Photoreceptor Cells from Exposure to Paclobutrazol.,2017,10.3390/ijms18010130,https://pubmed.ncbi.nlm.nih.gov/28085063/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,29500274,Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function.,2018,10.1085/jgp.201711815,https://pubmed.ncbi.nlm.nih.gov/29500274/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,22190596,GNAT1 associated with autosomal recessive congenital stationary night blindness.,2012,10.1167/iovs.11-8026,https://pubmed.ncbi.nlm.nih.gov/22190596/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT1,ENSG00000114349,Unsafe,1614872,Characterization of the human rod transducin alpha-subunit gene.,1992,10.1093/nar/20.11.2865,https://pubmed.ncbi.nlm.nih.gov/1614872/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,42869808,"[Mechanism of total iridoids from Gardeniae Fructus in treating ulcerative colitis based on ""bitterness drying dampness"" theory].",2026,10.19540/j.cnki.cjcmm.20260203.402,https://pubmed.ncbi.nlm.nih.gov/42869808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,42482221,"Topical nano-chitosan mitigates alendronate-induced lingual mucosal injury in rats: histological, immunohistochemical, molecular, and ultrastructural study.",2026,10.1186/s12903-026-09249-8,https://pubmed.ncbi.nlm.nih.gov/42482221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,41596643,Defining the Critical Role of α-Gustducin for NF-κB Inhibition and Anti-Inflammatory Signal Transduction by Bitter Agonists in Lung Epithelium.,2026,10.3390/ijms27020997,https://pubmed.ncbi.nlm.nih.gov/41596643/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,42542055,Berberine inhibits inflammatory bone resorption via bitter taste receptors.,2026,10.1016/j.phymed.2026.158637,https://pubmed.ncbi.nlm.nih.gov/42542055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,41755400,Postnatal developmental changes in the laryngeal chemosensory cell clusters of rats.,2026,10.1111/joa.70128,https://pubmed.ncbi.nlm.nih.gov/41755400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,42105813,The landscape of taste receptors in glioblastoma.,2026,10.1016/j.bcp.2026.118036,https://pubmed.ncbi.nlm.nih.gov/42105813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,41977441,Bitter Taste Signalling via TAS2R43 Enhances Temozolomide Efficacy in Glioblastoma Cells.,2026,10.3390/ijms27073262,https://pubmed.ncbi.nlm.nih.gov/41977441/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,41142782,Contribution of the bitter taste signaling pathway to lung inflammation during &lt;i&gt;Staphylococcus aureus&lt;/i&gt;-induced pneumonia.,2025,10.3389/fimmu.2025.1647780,https://pubmed.ncbi.nlm.nih.gov/41142782/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,42466736,Sublingual Caruncle Taste Buds Drive Taste Perception and Salivary Reflexes.,2026,10.1177/00220345261451849,https://pubmed.ncbi.nlm.nih.gov/42466736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,38155461,Genetic mutation of Tas2r104/Tas2r105/Tas2r114 cluster leads to a loss of taste perception to denatonium benzoate and cucurbitacin B.,2024,10.1002/ame2.12357,https://pubmed.ncbi.nlm.nih.gov/38155461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,40755411,Pig Taste Cell-derived Organoids Synthesize Insulin.,2025,10.1210/endocr/bqaf126,https://pubmed.ncbi.nlm.nih.gov/40755411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,38605968,Salicin alleviates periodontitis via Tas2r143/gustducin signaling in fibroblasts.,2024,10.3389/fimmu.2024.1374900,https://pubmed.ncbi.nlm.nih.gov/38605968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,38128683,Chronic social defeat stress broadly inhibits gene expression in the peripheral taste system and alters taste responses in mice.,2024,10.1016/j.physbeh.2023.114446,https://pubmed.ncbi.nlm.nih.gov/38128683/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,34422887,Drinking Non-nutritive Sweetness Solution of Sodium Saccharin or Rebaudioside a for Guinea Pigs: Influence on Histologic Change and Expression of Sweet Taste Receptors in Testis and Epididymis.,2021,10.3389/fnut.2021.720889,https://pubmed.ncbi.nlm.nih.gov/34422887/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,37262979,Immunohistochemical analysis of glutamatergic and serotonergic signaling pathways in chemosensory cell clusters in the pharynx and larynx of rats.,2023,10.1016/j.tice.2023.102122,https://pubmed.ncbi.nlm.nih.gov/37262979/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,39349166,"The Plastidial Protein Acetyltransferase GNAT1 Forms a Complex With GNAT2, yet Their Interaction Is Dispensable for State Transitions.",2024,10.1016/j.mcpro.2024.100850,https://pubmed.ncbi.nlm.nih.gov/39349166/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,32882403,The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice.,2021,10.1016/j.jcmgh.2020.08.011,https://pubmed.ncbi.nlm.nih.gov/32882403/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,36973308,Endocannabinoid administration affects taste preference and the expression of cannabinoid and opioid receptors in the amygdala of early lactating cows.,2023,10.1038/s41598-023-31724-3,https://pubmed.ncbi.nlm.nih.gov/36973308/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,36452076,Recovery of sweet taste preference in adult rats following bilateral chorda tympani nerve transection.,2022,10.7717/peerj.14455,https://pubmed.ncbi.nlm.nih.gov/36452076/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,38595815,Case report: EGFR fusion mutation combined with EGFR amplification responds to EGFR-TKI therapy.,2024,10.3389/fonc.2024.1347282,https://pubmed.ncbi.nlm.nih.gov/38595815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,33609226,Expression of TAS2R14 in the intestinal endocrine cells of non-human primates.,2021,10.1007/s13258-021-01054-7,https://pubmed.ncbi.nlm.nih.gov/33609226/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,31005972,New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances.,2019,10.1093/ajcn/nqz043,https://pubmed.ncbi.nlm.nih.gov/31005972/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,29683002,Short-term evaluation of hepatic toxicity of titanium dioxide nanofiber (TDNF).,2019,10.1080/01480545.2018.1459671,https://pubmed.ncbi.nlm.nih.gov/29683002/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,32138214,Oral Microbiota Profile Associates with Sugar Intake and Taste Preference Genes.,2020,10.3390/nu12030681,https://pubmed.ncbi.nlm.nih.gov/32138214/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,30055548,Short-Term Effects of Titanium Dioxide Nanofiber on the Renal Function of Male Sprague Dawley Rats.,2018,10.1615/jenvironpatholtoxicoloncol.2018025351,https://pubmed.ncbi.nlm.nih.gov/30055548/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,23818598,Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility.,2013,10.1073/pnas.1302827110,https://pubmed.ncbi.nlm.nih.gov/23818598/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,30891559,Ablation of NTPDase2+ cells inhibits the formation of filiform papillae in tongue tip.,2018,10.1002/ame2.12021,https://pubmed.ncbi.nlm.nih.gov/30891559/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,30369865,Ccl5 Mediates Proper Wiring of Feedforward and Lateral Inhibition Pathways in the Inner Retina.,2018,10.3389/fnins.2018.00702,https://pubmed.ncbi.nlm.nih.gov/30369865/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,27010324,A Comparison of Collection Techniques for Gene Expression Analysis of Human Oral Taste Tissue.,2016,10.1371/journal.pone.0152157,https://pubmed.ncbi.nlm.nih.gov/27010324/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,17376151,Perception of sweet taste is important for voluntary alcohol consumption in mice.,2008,10.1111/j.1601-183x.2007.00309.x,https://pubmed.ncbi.nlm.nih.gov/17376151/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,26633761,"Individual Differences Among Children in Sucrose Detection Thresholds: Relationship With Age, Gender, and Bitter Taste Genotype.",2016,10.1097/nnr.0000000000000138,https://pubmed.ncbi.nlm.nih.gov/26633761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,17724332,T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1.,2007,10.1073/pnas.0706678104,https://pubmed.ncbi.nlm.nih.gov/17724332/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,17021831,Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa.,2007,10.1007/s00359-006-0168-8,https://pubmed.ncbi.nlm.nih.gov/17021831/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,16728727,Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon.,2006,10.1152/ajpgi.00074.2006,https://pubmed.ncbi.nlm.nih.gov/16728727/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNAT3,ENSG00000214415,Unsafe,8015379,Human taste cells express the G protein alpha-gustducin and neuron-specific enolase.,1994,10.1016/0169-328x(94)90047-7,https://pubmed.ncbi.nlm.nih.gov/8015379/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,41836115,Astragaloside IV Ameliorates Diabetic Cardiomyopathy by Suppressing the GNG2/MRAS-ERK Signaling Pathway.,2026,10.2147/ijgm.s544287,https://pubmed.ncbi.nlm.nih.gov/41836115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,39805936,GNG2 inhibits brain metastases from colorectal cancer via PI3K/AKT/mTOR signaling pathway.,2025,10.1038/s41598-025-85592-0,https://pubmed.ncbi.nlm.nih.gov/39805936/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,42026034,Identification of susceptibility modules and genes through WGCNA and ceRNA network analysis in neuropathic pain-induced anxiodepression.,2026,10.1038/s41398-026-04041-2,https://pubmed.ncbi.nlm.nih.gov/42026034/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,41758220,PLCG1 promotes sevoflurane-induced neuronal ferroptosis by enhancing K63-linked ubiquitination and proteasomal degradation of LAMP2A.,2026,10.1007/s00221-026-07233-w,https://pubmed.ncbi.nlm.nih.gov/41758220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,40877393,Immune metabolic changes identify causal candidate genes and enable diagnostic frameworks in MAFLD.,2025,10.1038/s41598-025-17406-2,https://pubmed.ncbi.nlm.nih.gov/40877393/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,40530118,The prognostic and immune significance of fibronectin type III domain-containing 1 gene in pan-cancer and its relationship with proliferation and migration of stomach adenocarcinoma.,2025,10.21037/tcr-2024-2279,https://pubmed.ncbi.nlm.nih.gov/40530118/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,36497065,MAP4K4/JNK Signaling Pathway Stimulates Proliferation and Suppresses Apoptosis of Human Spermatogonial Stem Cells and Lower Level of MAP4K4 Is Associated with Male Infertility.,2022,10.3390/cells11233807,https://pubmed.ncbi.nlm.nih.gov/36497065/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,41075892,NONO and LncRNA NEAT1 orchestrate embryo implantation by paraspeckle-dependent CDC42SE1 mRNA nuclear retention.,2025,10.1016/j.ijbiomac.2025.148231,https://pubmed.ncbi.nlm.nih.gov/41075892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,40499775,Investigating the potential molecular mechanisms of dibutyltin dilaurate induced brain injury: a network toxicology and molecular docking approach.,2025,10.1016/j.envpol.2025.126642,https://pubmed.ncbi.nlm.nih.gov/40499775/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,35322009,GNG2 acts as a tumor suppressor in breast cancer through stimulating MRAS signaling.,2022,10.1038/s41419-022-04690-3,https://pubmed.ncbi.nlm.nih.gov/35322009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,35401859,Machine learning model for predicting Major Depressive Disorder using RNA-Seq data: optimization of classification approach.,2022,10.1007/s11571-021-09724-8,https://pubmed.ncbi.nlm.nih.gov/35401859/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,39595264,Genome-Wide Selection Signals Reveal Candidate Genes Associated with Plateau Adaptation in Tibetan Sheep.,2024,10.3390/ani14223212,https://pubmed.ncbi.nlm.nih.gov/39595264/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,34212982,"Interference with KCNJ2 inhibits proliferation, migration and EMT progression of apillary thyroid carcinoma cells by upregulating GNG2 expression.",2021,10.3892/mmr.2021.12261,https://pubmed.ncbi.nlm.nih.gov/34212982/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,37457231,Pharmacogenomics in the Management of Pulmonary Arterial Hypertension: Current Perspectives.,2023,10.2147/pgpm.s361222,https://pubmed.ncbi.nlm.nih.gov/37457231/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,38561663,Mining key circRNA-associated-ceRNA networks for milk fat metabolism in cows with varying milk fat percentages.,2024,10.1186/s12864-024-10252-y,https://pubmed.ncbi.nlm.nih.gov/38561663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,37720935,LncRNA-associated competing endogenous RNA network analysis uncovered key lncRNAs involved in temozolomide resistance and tumor recurrence of glioblastoma.,2023,10.1002/jmr.3060,https://pubmed.ncbi.nlm.nih.gov/37720935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,34580608,Identification of Potential Core Genes in Parkinson's Disease Using Bioinformatics Analysis.,2021,10.1155/2021/1690341,https://pubmed.ncbi.nlm.nih.gov/34580608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,34347369,Transcriptome profiling of five brain regions in a 6-hydroxydopamine rat model of Parkinson's disease.,2021,10.1111/cns.13702,https://pubmed.ncbi.nlm.nih.gov/34347369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,37927610,Differential drug response in pulmonary arterial hypertension: The potential for precision medicine.,2023,10.1002/pul2.12304,https://pubmed.ncbi.nlm.nih.gov/37927610/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,36603559,Identification of Hub Genes Correlated with the Initiation and Development in Chronic Kidney Disease via Bioinformatics Analysis.,2023,10.1159/000528870,https://pubmed.ncbi.nlm.nih.gov/36603559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,34630563,Molecular Analysis of Prognosis and Immune Pathways of Pancreatic Cancer Based on TNF Family Members.,2021,10.1155/2021/2676996,https://pubmed.ncbi.nlm.nih.gov/34630563/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,36504895,Enhancing progestin therapy via HDAC inhibitors in endometrial cancer.,2022,,https://pubmed.ncbi.nlm.nih.gov/36504895/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,35045088,Comparative analysis of protein-protein interaction networks in metastatic breast cancer.,2022,10.1371/journal.pone.0260584,https://pubmed.ncbi.nlm.nih.gov/35045088/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,34938350,circFAT1(e2) Inhibits Cell Apoptosis and Facilitates Progression in Vascular Smooth Muscle Cells through miR-298/MYB Axis.,2021,10.1155/2021/1922366,https://pubmed.ncbi.nlm.nih.gov/34938350/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,30927276,Pathway genes and metabolites in thiopurine therapy in Korean children with acute lymphoblastic leukaemia.,2019,10.1111/bcp.13943,https://pubmed.ncbi.nlm.nih.gov/30927276/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,33922375,Integrative Analysis of miRNA and mRNA Expression Profiles in Mammary Glands of Holstein Cows Artificially Infected with Staphylococcus aureus.,2021,10.3390/pathogens10050506,https://pubmed.ncbi.nlm.nih.gov/33922375/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,34532115,Identification of hub genes and functional modules in colon adenocarcinoma based on public databases by bioinformatics analysis.,2021,10.21037/jgo-21-415,https://pubmed.ncbi.nlm.nih.gov/34532115/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,28704922,Transcriptome Differences in Porcine Alveolar Macrophages from Tongcheng and Large White Pigs in Response to Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection.,2017,10.3390/ijms18071475,https://pubmed.ncbi.nlm.nih.gov/28704922/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,24624911,Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes.,2014,10.2217/pgs.13.226,https://pubmed.ncbi.nlm.nih.gov/24624911/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNG2,ENSG00000186469,Unsafe,10833460,"Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit.",2000,10.1006/bbrc.2000.2832,https://pubmed.ncbi.nlm.nih.gov/10833460/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,42590797,Single-Cell and Bulk Transcriptomics Identify GNGT1-High Malignant Epithelial Cells Associated With Immune Suppression in Esophageal Squamous Cell Carcinoma.,2026,10.1111/cbdd.70381,https://pubmed.ncbi.nlm.nih.gov/42590797/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,39958208,GNGT1 remodels the tumor microenvironment and promotes immune escape through enhancing tumor stemness and modulating the fibrinogen beta chain-neutrophil extracellular trap signaling axis in lung adenocarcinoma.,2025,10.21037/tlcr-2024-1200,https://pubmed.ncbi.nlm.nih.gov/39958208/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,40594780,GNGT1 is a potential prognostic and immunologic biomarker in gastric cancer.,2025,10.1038/s41598-025-08297-4,https://pubmed.ncbi.nlm.nih.gov/40594780/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,42671654,"Physiology and comparative transcriptomic analyses reveal the effects of food enrichment on the brain of yellow drum Nibea albiflora (Richardson, 1846).",2026,10.1007/s10695-026-01782-1,https://pubmed.ncbi.nlm.nih.gov/42671654/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,38928167,Maternal Hypermethylated Genes Contribute to Intrauterine Growth Retardation of Piglets in Rongchang Pigs.,2024,10.3390/ijms25126462,https://pubmed.ncbi.nlm.nih.gov/38928167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,41205780,Revealing the genetic blueprint: A transcriptomic approach to deciphering blue iris color formation in Nili-Ravi buffalo.,2026,10.1016/j.gene.2025.149878,https://pubmed.ncbi.nlm.nih.gov/41205780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,39739972,Identifying the NEAT1/miR-26b-5p/S100A2 axis as a regulator in Parkinson's disease based on the ferroptosis-related genes.,2024,10.1371/journal.pone.0316179,https://pubmed.ncbi.nlm.nih.gov/39739972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,39729945,Comparative proteomic analysis reveals the response mechanism of freshwater leech (Whitmania pigra) under heat-stress challenge.,2025,10.1016/j.cbd.2024.101406,https://pubmed.ncbi.nlm.nih.gov/39729945/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,38594908,The landscape of allelic expression and DNA methylation at the bovine SGCE/PEG10 locus.,2024,10.1111/age.13429,https://pubmed.ncbi.nlm.nih.gov/38594908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,33505535,Identified GNGT1 and NMU as Combined Diagnosis Biomarker of Non-Small-Cell Lung Cancer Utilizing Bioinformatics and Logistic Regression.,2021,10.1155/2021/6696198,https://pubmed.ncbi.nlm.nih.gov/33505535/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,34017995,Identification of potential diagnostic and prognostic biomarkers for LUAD based on TCGA and GEO databases.,2021,10.1042/bsr20204370,https://pubmed.ncbi.nlm.nih.gov/34017995/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,35939447,Regulation of rod photoreceptor function by farnesylated G-protein γ-subunits.,2022,10.1371/journal.pone.0272506,https://pubmed.ncbi.nlm.nih.gov/35939447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,36388046,"Expression of NMU, PPBP and GNG4 in colon cancer and their influences on prognosis.",2022,10.21037/tcr-22-1377,https://pubmed.ncbi.nlm.nih.gov/36388046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,34544905,Key genes affecting the progression of nasopharyngeal carcinoma identified by RNA-sequencing and bioinformatic analysis.,2021,10.18632/aging.203521,https://pubmed.ncbi.nlm.nih.gov/34544905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,38018267,Cross-species single-cell landscape of vertebrate pineal gland.,2024,10.1111/jpi.12927,https://pubmed.ncbi.nlm.nih.gov/38018267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,35394695,Role of hemoglobin alpha and hemoglobin beta in non-small-cell lung cancer based on bioinformatics analysis.,2022,10.1002/mc.23404,https://pubmed.ncbi.nlm.nih.gov/35394695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,35282133,Development of a prognostic nomogram based on an eight-gene signature for esophageal squamous cell carcinoma by weighted gene co-expression network analysis (WGCNA).,2022,10.21037/atm-21-6935,https://pubmed.ncbi.nlm.nih.gov/35282133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,35990977,Identification of key genes for hypertrophic cardiomyopathy using integrated network analysis of differential lncRNA and gene expression.,2022,10.3389/fcvm.2022.946229,https://pubmed.ncbi.nlm.nih.gov/35990977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,36202277,Five hub genes contributing to the oncogenesis and trastuzumab-resistance in gastric cancer.,2023,10.1016/j.gene.2022.146942,https://pubmed.ncbi.nlm.nih.gov/36202277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,34220331,The underlying molecular mechanism and drugs for treatment in adrenal cortical carcinoma.,2021,10.7150/ijms.60261,https://pubmed.ncbi.nlm.nih.gov/34220331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,41344185,Visual toxicity of imidacloprid in zebrafish: Unraveling the pathways from ocular morphology to behavior via phototransduction dysregulation.,2026,10.1016/j.jhazmat.2025.140693,https://pubmed.ncbi.nlm.nih.gov/41344185/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,34995633,Antagonistic effects and mechanisms of carbendazim and chlorpyrifos on the neurobehavior of larval zebrafish.,2022,10.1016/j.chemosphere.2022.133522,https://pubmed.ncbi.nlm.nih.gov/34995633/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,29278617,Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci.,2018,10.1097/fpc.0000000000000318,https://pubmed.ncbi.nlm.nih.gov/29278617/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,29524779,Transcriptomic analyses of tributyltin-induced sexual dimorphisms in rare minnow (Gobiocypris rarus) brains.,2018,10.1016/j.ecoenv.2018.02.049,https://pubmed.ncbi.nlm.nih.gov/29524779/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,30760287,Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke.,2019,10.1186/s12967-019-1790-x,https://pubmed.ncbi.nlm.nih.gov/30760287/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,30652029,Predicting responses to platin chemotherapy agents with biochemically-inspired machine learning.,2019,10.1038/s41392-018-0034-5,https://pubmed.ncbi.nlm.nih.gov/30652029/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GNGT1,ENSG00000127928,Unsafe,17655910,Identification of novel retinal target genes of thyroid hormone in the human WERI cells by expression microarray analysis.,2007,10.1016/j.visres.2007.04.023,https://pubmed.ncbi.nlm.nih.gov/17655910/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,42072025,Transcriptional and Alternative Splicing Regulation of Autophagy and Vesicle Transport Pathways in Large Yellow Croaker Cells During Megalocytivirus Infection.,2026,10.3390/ani16081259,https://pubmed.ncbi.nlm.nih.gov/42072025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,41532421,Overexpression of Gopc Promotes Cardiomyocyte Proliferation but Delays Overall Heart Regeneration in Zebrafish.,2026,10.1002/cbin.70123,https://pubmed.ncbi.nlm.nih.gov/41532421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,41147487,Trans-synaptic signaling through GRID1/glutamate receptor delta-1 and CBLN1/cerebellin-1 facilitates autophagic flux in central amygdala and prevents chronic pain.,2025,10.1080/15548627.2025.2574968,https://pubmed.ncbi.nlm.nih.gov/41147487/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,42444827,Case Report: A case series on actionable genomic alterations guiding effective targeted therapy in rare sarcomas.,2026,10.3389/fonc.2026.1842108,https://pubmed.ncbi.nlm.nih.gov/42444827/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,41044121,Discovering periodontitis biomarkers and therapeutic targets through bioinformatics and ensemble learning analysis.,2025,10.1038/s41598-025-18017-7,https://pubmed.ncbi.nlm.nih.gov/41044121/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,41840584,TCOF1 affects Golgi secretory pathway contributing to the angiogenesis in renal cancer.,2026,10.1186/s12964-026-02796-1,https://pubmed.ncbi.nlm.nih.gov/41840584/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,40718865,Understanding oncological and sexual function outcomes with gynaecological organ preserving cystectomy in women with bladder cancer; a systematic review.,2025,10.1002/bco2.70053,https://pubmed.ncbi.nlm.nih.gov/40718865/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,41790556,Functionally distinct ALK and ROS1 fusions detected in infant-type hemispheric gliomas converge on STAT3 and SHP2 activation.,2026,10.1016/j.celrep.2026.117046,https://pubmed.ncbi.nlm.nih.gov/41790556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,38845690,Prolonged response to entrectinib in an adult patient with recurrent glioblastoma harboring a GOPC::ROS1 fusion.,2024,10.1093/noajnl/vdae077,https://pubmed.ncbi.nlm.nih.gov/38845690/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,42871792,Molecular genetic analysis of a case report of undifferentiated pleomorphic sarcoma with rhabdomyosarcomatous differentiation: insights from whole-exome sequencing and literature review.,2026,10.21037/acr-2026-0106,https://pubmed.ncbi.nlm.nih.gov/42871792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,41152457,Alginate encapsulated cell blocks improve diagnostic consistency and long term specimen integrity in routine pathological diagnostics and cancer research.,2025,10.1038/s41598-025-21615-0,https://pubmed.ncbi.nlm.nih.gov/41152457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,41260362,Proteome-wide multi-trait association analyses prioritize candidate proteins and therapeutic targets for psychiatric disorders.,2026,10.1016/j.jad.2025.120712,https://pubmed.ncbi.nlm.nih.gov/41260362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,41668650,Actin-related protein T3 is required for acrosome biogenesis and sperm function in mice.,2026,10.1242/dev.205283,https://pubmed.ncbi.nlm.nih.gov/41668650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,38436022,Identification of m6A-associated autophagy genes in non-alcoholic fatty liver.,2024,10.7717/peerj.17011,https://pubmed.ncbi.nlm.nih.gov/38436022/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,40853519,Treponema pallidum inhibits CD4+ T-cell proliferation through METAP2: insights from Mendelian randomization analysis.,2025,10.1186/s13568-025-01940-3,https://pubmed.ncbi.nlm.nih.gov/40853519/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,34870349,Zona Pellucida sperm-binding protein 3 receptor distribution during Gopc-/- globozoospermic spermatogenesis.,2022,10.1002/jemt.24009,https://pubmed.ncbi.nlm.nih.gov/34870349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,34383253,The Golgi-Associated PDZ Domain Protein Gopc/PIST Is Required for Synaptic Targeting of mGluR5.,2021,10.1007/s12035-021-02504-9,https://pubmed.ncbi.nlm.nih.gov/34383253/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,36660680,Methylation-based epigenetic studies and gene integration analysis of preeclampsia.,2022,10.21037/atm-22-5556,https://pubmed.ncbi.nlm.nih.gov/36660680/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,37596590,"Drug landscape in patients receiving general outpatient palliative care in Germany: results from a retrospective analysis of 10,464 patients.",2023,10.1186/s12904-023-01231-3,https://pubmed.ncbi.nlm.nih.gov/37596590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,38195220,Clinicopathological analysis of BRAF and non-BRAF MAPK pathway-altered gliomas in paediatric and adult patients: a single-institution study of 40 patients.,2025,10.1136/jcp-2023-209318,https://pubmed.ncbi.nlm.nih.gov/38195220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,41814533,The Impact of Initiating the Older Adult Surgical Inpatient Service on the Quantity and Quality of Goals of Patient Care Documentation.,2026,10.1111/ajag.70146,https://pubmed.ncbi.nlm.nih.gov/41814533/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,42680433,Chronic glyphosate exposure compromises male reproductive health: Golgi dysfunction mediating spermatogenesis impairment.,2026,10.1016/j.jes.2026.03.018,https://pubmed.ncbi.nlm.nih.gov/42680433/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,42424348,Who chooses telehealth? A cross-sectional cohort study of diabetic patients in outpatient clinic follow-up.,2026,10.1371/journal.pdig.0001545,https://pubmed.ncbi.nlm.nih.gov/42424348/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,41941948,Economic burden of smoking: evidence from a 1.6 million cohort in Hong Kong.,2026,10.1016/j.amjmed.2026.03.034,https://pubmed.ncbi.nlm.nih.gov/41941948/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,38902080,Effectiveness of post-COVID-19 primary care attendance in improving survival in very old patients with multimorbidity: a territory-wide target trial emulation.,2024,10.3399/bjgp24x737517,https://pubmed.ncbi.nlm.nih.gov/38902080/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,39934825,Experiences and reflections of doctors on the operations of designated clinics during the COVID-19 pandemic in Hong Kong: a qualitative study.,2025,10.1186/s12913-025-12390-9,https://pubmed.ncbi.nlm.nih.gov/39934825/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,37666787,Influenza vaccine uptake and associated factors in adult patients with type 2 diabetes in a general outpatient clinic in Hong Kong.,2023,10.31128/ajgp-11-22-6621,https://pubmed.ncbi.nlm.nih.gov/37666787/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,34076666,Evaluation of Crizotinib Treatment in a Patient With Unresectable GOPC-ROS1 Fusion Agminated Spitz Nevi.,2021,10.1001/jamadermatol.2021.0025,https://pubmed.ncbi.nlm.nih.gov/34076666/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,36053834,ROS1 genomic rearrangements are rare actionable drivers in microsatellite stable colorectal cancer.,2022,10.1002/ijc.34257,https://pubmed.ncbi.nlm.nih.gov/36053834/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,33027661,Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation.,2020,10.1016/j.celrep.2020.108235,https://pubmed.ncbi.nlm.nih.gov/33027661/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,37954374,Prediction of the interaction between Calloselasma rhodostoma venom-derived peptides and cancer-associated hub proteins: A computational study.,2023,10.1016/j.heliyon.2023.e21149,https://pubmed.ncbi.nlm.nih.gov/37954374/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,11707463,A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression.,2002,10.1074/jbc.m110177200,https://pubmed.ncbi.nlm.nih.gov/11707463/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,11384996,Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6.,2001,10.1074/jbc.m104137200,https://pubmed.ncbi.nlm.nih.gov/11384996/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GOPC,ENSG00000047932,Unsafe,11162552,PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10.,2001,10.1006/bbrc.2000.4160,https://pubmed.ncbi.nlm.nih.gov/11162552/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,42148317,"Integrative analysis identifies DCBLD2 and immune-related biomarkers for major depressive disorder: evidence from human peripheral blood, post-mortem brain, and rat models.",2026,10.3389/fnhum.2026.1770103,https://pubmed.ncbi.nlm.nih.gov/42148317/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,41828395,Integrative Proteomic and Transcriptomic Profiling Identifies Candidate Biomarkers for Discriminating Anaphylactic from Cardiac Sudden Death.,2026,10.3390/ijms27052166,https://pubmed.ncbi.nlm.nih.gov/41828395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,42717812,Coagulation Factor VII (FVII 401G&gt;T) and glycoprotein Ib alpha (GP1BA Kozak -5C/T) gene variants as predictors of acute coronary syndrome in Indians: evidence from a case-control study.,2026,10.1080/17520363.2026.2729224,https://pubmed.ncbi.nlm.nih.gov/42717812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,41340014,Revealing Causal Protein Biomarkers and Potential Therapeutic Targets for Histologic-Specific Lung Cancer.,2025,10.1111/jcmm.70866,https://pubmed.ncbi.nlm.nih.gov/41340014/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,41357175,NETs promote invasive behavior of fibroblast-like synoviocytes through GPIbα in rheumatoid arthritis.,2025,10.3389/fimmu.2025.1667319,https://pubmed.ncbi.nlm.nih.gov/41357175/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,42299353,Proteomics in myelodysplastic syndromes: towards novel prognostic and diagnostic biomarkers.,2026,10.11613/bm.2026.020504,https://pubmed.ncbi.nlm.nih.gov/42299353/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,42229093,Molecular genetic diagnosis of Bernard-Soulier syndrome in Iranian patients: reporting three novel mutations.,2026,10.1016/j.transci.2026.104456,https://pubmed.ncbi.nlm.nih.gov/42229093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,42500573,"miR-320d Is Associated with Reduced Nasopharyngeal Carcinoma Progression, Potentially through the NF-κB/IL-8 Axis-Mediated Inhibition of Neutrophil Extracellular Trap Formation.",2026,10.32604/or.2026.081869,https://pubmed.ncbi.nlm.nih.gov/42500573/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,42411742,Dysregulated proteins in plasma distinguishing Loeys-Dietz syndrome from other heritable thoracic aortic disease - an explorative study.,2026,10.1080/14017431.2026.2699504,https://pubmed.ncbi.nlm.nih.gov/42411742/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,42445529,"Several antiplatelet gene SNPs, their haplotypes and &lt;i&gt;G&lt;/i&gt; × &lt;i&gt;E&lt;/i&gt; interactions on premature coronary artery disease.",2026,10.3389/fcvm.2026.1875319,https://pubmed.ncbi.nlm.nih.gov/42445529/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,40597893,A novel gene signature for forecasting time to next relapse in multiple sclerosis using peripheral blood mononuclear cells.,2025,10.1186/s12883-025-04231-3,https://pubmed.ncbi.nlm.nih.gov/40597893/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,42873976,"SGLT1/2 inhibitor sotagliflozin, but not SGLT2-selective inhibitor empagliflozin, attenuates platelet activation and thrombosis.",2026,10.1172/jci201899,https://pubmed.ncbi.nlm.nih.gov/42873976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,40045897,Increased RhoA pathway activation downstream of αIIbβ3/SRC contributes to heterozygous Bernard Soulier syndrome.,2025,10.3324/haematol.2024.286424,https://pubmed.ncbi.nlm.nih.gov/40045897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,42158830,From Extracellular Vesicles-Related Genes to Angiogenesis: KRT7 as a Modulator of the VEGF/VEGFR signaling-dependent angiogenesis in Pancreatic Adenocarcinoma.,2026,10.7150/ijms.129654,https://pubmed.ncbi.nlm.nih.gov/42158830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,39554251,Integrated analysis of multi-omics data for the discovery of biomarkers and therapeutic targets for juvenile idiopathic arthritis.,2024,10.1016/j.jtauto.2024.100256,https://pubmed.ncbi.nlm.nih.gov/39554251/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,42150413,Integrative transcriptomics elucidates core regulatory network governing human megakaryopoiesis: Insights from CD34&lt;sup&gt;+&lt;/sup&gt;-derived megakaryocyte maturation.,2026,10.1016/j.thromres.2026.109709,https://pubmed.ncbi.nlm.nih.gov/42150413/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,42406052,Deep Dive into Evolution: How Cetaceans Adapt Their Anticoagulant Genes for Underwater Survival.,2026,10.1007/s00239-026-10326-3,https://pubmed.ncbi.nlm.nih.gov/42406052/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,40941697,Clinical Utility of a Targeted Next-Generation Sequencing Panel for Inherited Platelet Disorders in Children.,2025,10.3390/diagnostics15172210,https://pubmed.ncbi.nlm.nih.gov/40941697/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,40022872,Quantitative serum proteomic analysis for biomarker discovery in post-COVID-19 postural orthostatic tachycardia syndrome (PC-POTS) patients.,2025,10.1016/j.autneu.2025.103247,https://pubmed.ncbi.nlm.nih.gov/40022872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,40806633,"Genetic Associations of &lt;i&gt;ITGB3&lt;/i&gt;, &lt;i&gt;FGG&lt;/i&gt;, &lt;i&gt;GP1BA&lt;/i&gt;, &lt;i&gt;PECAM1&lt;/i&gt;, and &lt;i&gt;PEAR1&lt;/i&gt; Polymorphisms and the Platelet Activation Pathway with Recurrent Pregnancy Loss in the Korean Population.",2025,10.3390/ijms26157505,https://pubmed.ncbi.nlm.nih.gov/40806633/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,40777024,Identification of a coagulation-related classification and signature that predict disease heterogeneity for colorectal cancer and pan-cancer patients.,2025,10.3389/fimmu.2025.1572701,https://pubmed.ncbi.nlm.nih.gov/40777024/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,42224635,Identification of Novel Genetic Risk Variants Associated With Early-Onset Ischemic Stroke in Taiwan.,2026,10.1212/wnl.0000000000218126,https://pubmed.ncbi.nlm.nih.gov/42224635/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,42258512,Plasma proteomics improves risk prediction in heart failure and reveals unique biology in chronic chagas cardiomyopathy.,2026,10.1371/journal.pntd.0014370,https://pubmed.ncbi.nlm.nih.gov/42258512/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,40775216,Murine hematopoietic progenitor cell lines with erythroid and megakaryocyte potential.,2025,10.1038/s41467-025-62668-z,https://pubmed.ncbi.nlm.nih.gov/40775216/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,38299390,"Genetic Polymorphisms of GP1BA, PEAR1, and PAI-1 may be Associated with Serum sIgE and Blood Eosinophil Levels in Chinese Patients with Allergic Diseases.",2024,10.2174/0118715303285101240118062549,https://pubmed.ncbi.nlm.nih.gov/38299390/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,37622117,Megakaryocyte NLRP3 hyperactivation induces mild anemia and potentiates inflammatory response in mice.,2023,10.3389/fimmu.2023.1226196,https://pubmed.ncbi.nlm.nih.gov/37622117/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,41301514,Plasma Extracellular Vesicles Contain Protein Biomarkers for Capturing Stages of Metabolic Dysfunction-Associated Steatotic Liver Disease: A Preliminary Exploratory Study.,2025,10.3390/biom15111596,https://pubmed.ncbi.nlm.nih.gov/41301514/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,40527822,Exploring potential therapeutic targets for cardiomyopathy: A proteome-wide Mendelian randomization analysis.,2025,10.1097/md.0000000000042681,https://pubmed.ncbi.nlm.nih.gov/40527822/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,37586776,Model based on single-nucleotide polymorphism to discriminate aspirin resistance patients.,2024,10.1136/svn-2022-002228,https://pubmed.ncbi.nlm.nih.gov/37586776/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,36911417,The 4G/5G polymorphism of plasminogen activator inhibitor type 1 is a predictor of allergic cough.,2023,10.3389/fgene.2023.1139813,https://pubmed.ncbi.nlm.nih.gov/36911417/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,34333846,The Copenhagen founder variant GP1BA c.58T>G is the most frequent cause of inherited thrombocytopenia in Denmark.,2021,10.1111/jth.15479,https://pubmed.ncbi.nlm.nih.gov/34333846/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GP1BA,ENSG00000185245,Unsafe,39859144,The Platelet-Specific Gene Signature in the Immunoglobulin G4-Related Disease Transcriptome.,2025,10.3390/medicina61010162,https://pubmed.ncbi.nlm.nih.gov/39859144/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,42761201,Repurposed metformin-apigenin combination therapy for metabolic dysfunction-associated steatohepatitis: from integrative multi-omics discovery to &lt;i&gt;in vivo&lt;/i&gt; validation.,2026,10.3389/fphar.2026.1857676,https://pubmed.ncbi.nlm.nih.gov/42761201/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,42340815,Triiodothyroacetic acid exerts tissue-specific thyromimetic effects without tachycardia and hyperthermia in male mice.,2026,10.1530/etj-26-0102,https://pubmed.ncbi.nlm.nih.gov/42340815/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,42157969,Multi-omics Mendelian randomization identifies mitochondrial genes associated with immune microenvironment signatures in endometriosis.,2026,10.3389/frph.2026.1747031,https://pubmed.ncbi.nlm.nih.gov/42157969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,42625051,Bifidobacterium longum engineered with artificial enzymes alleviates high-altitude colitis via inhibition of GPD2-dependent ferroptosis.,2026,10.1007/s00709-026-02251-5,https://pubmed.ncbi.nlm.nih.gov/42625051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,41981083,Glycerol enhances mitochondrial metabolism and inflammatory response in pro-inflammatory macrophages.,2026,10.1038/s44319-026-00747-y,https://pubmed.ncbi.nlm.nih.gov/41981083/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,41313944,The role of GPD2 on ferroptosis in sepsis-induced acute lung injury.,2026,10.1016/j.bbrc.2025.153066,https://pubmed.ncbi.nlm.nih.gov/41313944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,41068957,The role of GPD2 and glycolysis-related genes in cholangiocarcinoma: insights into prognostic biomarkers and tumor-immune interactions.,2025,10.1186/s12935-025-03965-x,https://pubmed.ncbi.nlm.nih.gov/41068957/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,41759568,"Electrical acceleration of the glycerophosphate shuttle by the VDAC1,2-hexokinase complexes of mitochondria.",2026,10.1016/j.bbabio.2026.149586,https://pubmed.ncbi.nlm.nih.gov/41759568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,42004709,Integrating co-expression network analysis and machine learning to reveal the regulatory landscape of &lt;i&gt;GPD&lt;/i&gt; genes in &lt;i&gt;Chlamydomonas reinhardtii&lt;/i&gt; under salinity stress.,2026,10.7717/peerj.21060,https://pubmed.ncbi.nlm.nih.gov/42004709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,40074769,Integrated analysis and experimental validation reveal the prognostic and immunological features associated with coagulation in hepatocellular carcinoma.,2025,10.1038/s41598-025-85491-4,https://pubmed.ncbi.nlm.nih.gov/40074769/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,42821293,Multi-omics analyses prioritize potential biomarkers and drug targets for obstructive sleep apnea.,2026,10.1093/sleep/zsag262,https://pubmed.ncbi.nlm.nih.gov/42821293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,41828845,A Novel Wogonin Derivative Induces Apoptosis in PC-3M Cells by Targeting Mitochondrial Dysfunction and Activating the ROS-p38/MAPK Pathway.,2026,10.3390/molecules31050859,https://pubmed.ncbi.nlm.nih.gov/41828845/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,40682019,GPD2 inhibition impairs coagulation function via ROS/NF-κB/P2Y12 pathway.,2025,10.1186/s11658-025-00759-x,https://pubmed.ncbi.nlm.nih.gov/40682019/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,41151774,Effects of Eicosapentaenoic Acid on the Glycerophosphate Shuttle-Regulated Inflammatory and Thermogenic Responses.,2026,10.1002/oby.70053,https://pubmed.ncbi.nlm.nih.gov/41151774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,41007695,Identification of Key Biomarkers Related to Lipid Metabolism in Acute Pancreatitis and Their Regulatory Mechanisms Based on Bioinformatics and Machine Learning.,2025,10.3390/biomedicines13092132,https://pubmed.ncbi.nlm.nih.gov/41007695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,39054490,KM04416 suppressed lung adenocarcinoma progression by promoting immune infiltration.,2024,10.1186/s13019-024-02971-w,https://pubmed.ncbi.nlm.nih.gov/39054490/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,38689091,Glycerol 3-phosphate dehydrogenases (1 and 2) in cancer and other diseases.,2024,10.1038/s12276-024-01222-1,https://pubmed.ncbi.nlm.nih.gov/38689091/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,41099664,Impact of CRISPRi-Mediated Titration of &lt;i&gt;GPD&lt;/i&gt; Genes on the Fermentative Performance of &lt;i&gt;S. cerevisiae&lt;/i&gt;.,2025,10.1021/acssynbio.5c00316,https://pubmed.ncbi.nlm.nih.gov/41099664/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,41281601,Areca nut extract exposure disrupts myogenesis and metabolism in C2C12 cells.,2025,10.1016/j.crtox.2025.100264,https://pubmed.ncbi.nlm.nih.gov/41281601/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,41508879,Long Duration of Type 2 Diabetes Drives Erythrocyte-Induced Vascular Endothelial Dysfunction: A Link to miRNA-210-3p.,2026,10.2337/db25-0463,https://pubmed.ncbi.nlm.nih.gov/41508879/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,42785618,Integrating multi-omics and machine learning to predict microplastic cytotoxicity under leave-one-polymer-out validation.,2026,10.1016/j.envpol.2026.129208,https://pubmed.ncbi.nlm.nih.gov/42785618/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,41350307,"Discovering bioactive pharmaceuticals from natural products for type 2 diabetes mellitus using network pharmacology, molecular docking, and molecular dynamics.",2025,10.1038/s41598-025-27173-9,https://pubmed.ncbi.nlm.nih.gov/41350307/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,41620417,Targeting glycerophospholipid biosynthesis overcomes chemoresistance driven by SLFN11 loss in Ewing sarcoma.,2026,10.1038/s41419-026-08432-7,https://pubmed.ncbi.nlm.nih.gov/41620417/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,42188014,Prolonged Deltamethrin Exposure Induces Dose-Dependent Glycerol Overproduction and Efficient Deltamethrin Removal by &lt;i&gt;Saccharomyces cerevisiae&lt;/i&gt;.,2026,10.3390/metabo16050305,https://pubmed.ncbi.nlm.nih.gov/42188014/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,41301882,An Integrated Multi-Omics Analysis Identifies Oxeiptosis-Related Biomarkers in Diabetic Retinopathy.,2025,10.3390/biomedicines13112789,https://pubmed.ncbi.nlm.nih.gov/41301882/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,40427441,Guanidinoacetic Acid and Methionine Supplementation Improve the Growth Performance of Beef Cattle via Regulating the Antioxidant Levels and Protein and Lipid Metabolisms in Serum and Liver.,2025,10.3390/antiox14050559,https://pubmed.ncbi.nlm.nih.gov/40427441/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,35749365,A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria.,2022,10.1073/pnas.2121987119,https://pubmed.ncbi.nlm.nih.gov/35749365/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPD2,ENSG00000115159,Unsafe,40999319,Integrated HS-SPME-GC/MS and RNA sequencing analysis reveals metabolic differences of flavor compounds of muscle tissues with different intramuscular fat contents from Tibetan sheep.,2025,10.1186/s12864-025-11997-w,https://pubmed.ncbi.nlm.nih.gov/40999319/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,42848422,Transcriptional regulation and function of GPR18 in macrophage subtype specification.,2026,10.1073/pnas.2612173123,https://pubmed.ncbi.nlm.nih.gov/42848422/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,42719828,Mechanistic Insights into Maxing Shigan Decoction in Community-Acquired Pneumonia Based on Bioinformatics and Experimental Validation.,2026,10.2147/idr.s637858,https://pubmed.ncbi.nlm.nih.gov/42719828/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,42114685,"Targeting GPR18: Structural modelling, ligand discovery, and therapeutic potential in neuroinflammatory disorders.",2026,10.1016/j.bcp.2026.118038,https://pubmed.ncbi.nlm.nih.gov/42114685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,41596488,GPR18 Deletion in Mice Inversely Affects Vasoactive Signaling and Passive Biomechanical Properties of the Thoracic Aorta and Femoral Artery.,2026,10.3390/ijms27020841,https://pubmed.ncbi.nlm.nih.gov/41596488/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,41294926,S1P&lt;sub&gt;3&lt;/sub&gt; Receptor Mediates the Proinflammatory Effect of the Endocannabinoid 2-Arachidonoylglycerol in Endometriotic Epithelial Cells.,2025,10.1096/fj.202502415r,https://pubmed.ncbi.nlm.nih.gov/41294926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,42203173,Intestinal colonization of germ-free mice with indole-producing E. coli modulates the central and peripheral endocannabinoidome.,2026,10.1016/j.jlr.2026.101070,https://pubmed.ncbi.nlm.nih.gov/42203173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,41324396,Vascular Bed-Specific Endothelial Dysfunction and Age-Dependent Circadian Hypertension in Mice Lacking the Resolvin D2 Receptor GPR18.,2025,10.1096/fj.202503386r,https://pubmed.ncbi.nlm.nih.gov/41324396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,42572649,Emerging roles of cannabinoid pathways in renal injury and repair.,2026,10.3389/fphar.2026.1777644,https://pubmed.ncbi.nlm.nih.gov/42572649/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,42777907,Identification and functional experimental verification of efferocytosis-related diagnostic biomarkers for sepsis.,2026,10.1016/j.biocel.2026.107037,https://pubmed.ncbi.nlm.nih.gov/42777907/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,41699832,Differential Expression of Endocannabinoid Receptors in Lesional and Non-Lesional Skin of Psoriasis Patients: Insights Into Pathogenesis and Potential Therapeutic Targets.,2026,10.1177/12034754251355199,https://pubmed.ncbi.nlm.nih.gov/41699832/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,39320982,Resolvin D2/GPR18 signaling enhances monocytic myeloid-derived suppressor cell function to mitigate abdominal aortic aneurysm formation.,2024,10.1096/fj.202400414rrr,https://pubmed.ncbi.nlm.nih.gov/39320982/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,38542895,Uncovering the Power of GPR18 Signalling: How RvD2 and Other Ligands Could Have the Potential to Modulate and Resolve Inflammation in Various Health Disorders.,2024,10.3390/molecules29061258,https://pubmed.ncbi.nlm.nih.gov/38542895/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,39490925,Resolvin D2/GPR 18 axis ameliorates pressure overload-induced heart failure by inhibiting pro-inflammatory macrophage polarization.,2024,10.1016/j.jlr.2024.100679,https://pubmed.ncbi.nlm.nih.gov/39490925/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,41282589,Repolarization of inflammatory macrophages into reparative stage targeting cannabinoid receptor2: a potential perspective to dampen lung injury/ARDS.,2025,10.3389/fphar.2025.1623857,https://pubmed.ncbi.nlm.nih.gov/41282589/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,39816195,Lipid-mediated resolution of inflammation and survival in amyotrophic lateral sclerosis.,2025,10.1093/braincomms/fcae402,https://pubmed.ncbi.nlm.nih.gov/39816195/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,41872506,Engineering NK and T cells with metabolite-sensing receptors to target solid tumors.,2026,10.1038/s41590-026-02473-y,https://pubmed.ncbi.nlm.nih.gov/41872506/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,41875505,G protein-coupled receptors and inflammation resolution signaling networks in the heart: Pharmacology and potential for innovative therapeutics.,2026,10.1016/j.pharmr.2026.100129,https://pubmed.ncbi.nlm.nih.gov/41875505/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,40886662,Integrative bioinformatic discovery and in vivo validation of immune-related hub genes in renal interstitial fibrosis.,2026,10.1016/j.compbiolchem.2025.108632,https://pubmed.ncbi.nlm.nih.gov/40886662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,41335534,G protein coupled receptor 18 activation during experimental colitis in mice.,2025,10.26402/jpp.2025.4.06,https://pubmed.ncbi.nlm.nih.gov/41335534/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,40759181,Resolvin D2 limits senescent cell accumulation in atherosclerotic plaques.,2025,10.1016/j.vph.2025.107527,https://pubmed.ncbi.nlm.nih.gov/40759181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,41158255,Establishment of a prognostic model and immune profiling based on phagocytic regulatory genes in hepatocellular carcinoma.,2025,10.21037/tcr-2025-207,https://pubmed.ncbi.nlm.nih.gov/41158255/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,39559348,Identification of novel markers for neuroblastoma immunoclustering using machine learning.,2024,10.3389/fimmu.2024.1446273,https://pubmed.ncbi.nlm.nih.gov/39559348/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,37038675,"GPR18 and GPR55-related Ligands Serving as Antagonists or Agonists: Current Situation, Challenges and Perspectives.",2023,10.2174/1573406419666230406095220,https://pubmed.ncbi.nlm.nih.gov/37038675/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,38255280,Immunosuppression in Sepsis: Biomarkers and Specialized Pro-Resolving Mediators.,2024,10.3390/biomedicines12010175,https://pubmed.ncbi.nlm.nih.gov/38255280/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,37717941,Resolvin D2-G-Protein Coupled Receptor 18 Enhances Bone Marrow Function and Limits Steatosis and Hepatic Collagen Accumulation in Aging.,2023,10.1016/j.ajpath.2023.08.011,https://pubmed.ncbi.nlm.nih.gov/37717941/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,37240392,"Novel GPR18 Ligands in Rodent Pharmacological Tests: Effects on Mood, Pain, and Eating Disorders.",2023,10.3390/ijms24109046,https://pubmed.ncbi.nlm.nih.gov/37240392/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,36389671,CD4+-mediated colitis in mice is independent of the GPR183 and GPR18 pathways.,2022,10.3389/fimmu.2022.1034648,https://pubmed.ncbi.nlm.nih.gov/36389671/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,39867577,Depression-related innate immune genes and pan-cancer gene analysis and validation.,2024,10.3389/fgene.2024.1521238,https://pubmed.ncbi.nlm.nih.gov/39867577/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,37128607,N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+T cell responsiveness.,2023,10.1016/j.isci.2023.106578,https://pubmed.ncbi.nlm.nih.gov/37128607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,38216984,The synthetic cannabinoids menace: a review of health risks and toxicity.,2024,10.1186/s40001-023-01443-6,https://pubmed.ncbi.nlm.nih.gov/38216984/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,40649782,Resolvin D2 and Its Effects on the Intestinal Mucosa of Crohn's Disease Patients: A Promising Immune Modulation Therapeutic Target.,2025,10.3390/ijms26136003,https://pubmed.ncbi.nlm.nih.gov/40649782/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,36982628,The Mechanisms of GPR55 Receptor Functional Selectivity during Apoptosis and Proliferation Regulation in Cancer Cells.,2023,10.3390/ijms24065524,https://pubmed.ncbi.nlm.nih.gov/36982628/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,27572937,Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18.,2016,10.1038/srep32255,https://pubmed.ncbi.nlm.nih.gov/27572937/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR18,ENSG00000125245,Unsafe,16844083,Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.,2006,10.1016/j.bbrc.2006.06.175,https://pubmed.ncbi.nlm.nih.gov/16844083/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,41582432,G Protein-Coupled Receptor 32 Contributes to Inflammation Resolution and Neuronal Excitability Dysfunction in Patients With Focal Cortical Dysplasia IIb and Tuberous Sclerosis Complex.,2026,10.1111/nan.70062,https://pubmed.ncbi.nlm.nih.gov/41582432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,39816195,Lipid-mediated resolution of inflammation and survival in amyotrophic lateral sclerosis.,2025,10.1093/braincomms/fcae402,https://pubmed.ncbi.nlm.nih.gov/39816195/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,41161773,"Unraveling Shared Diagnostic Biomarkers: Integrated Bioinformatics Identification of CGB7, MYCNUT, and GPR32 in Gestational Diabetes Mellitus and Retinopathy of Prematurity.",2026,10.1620/tjem.2025.j118,https://pubmed.ncbi.nlm.nih.gov/41161773/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,41026459,Elucidate biomarkers and the molecular pathways associated with genetic variants that contribute to the etiology of Parkinson's disease.,2025,10.1007/s13760-025-02897-7,https://pubmed.ncbi.nlm.nih.gov/41026459/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,41875505,G protein-coupled receptors and inflammation resolution signaling networks in the heart: Pharmacology and potential for innovative therapeutics.,2026,10.1016/j.pharmr.2026.100129,https://pubmed.ncbi.nlm.nih.gov/41875505/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,35808844,Expression and function of resolvin RvD1n-3 DPA receptors in oral epithelial cells.,2022,10.1111/eos.12883,https://pubmed.ncbi.nlm.nih.gov/35808844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,34699386,The resolvin D1 receptor GPR32 transduces inflammation resolution and atheroprotection.,2021,10.1172/jci142883,https://pubmed.ncbi.nlm.nih.gov/34699386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,39959641,Inflammatory Gene Signature Identified by Machine Algorithms Reveals Novel Biomarkers of Coronary Artery Disease.,2025,10.2147/jir.s496046,https://pubmed.ncbi.nlm.nih.gov/39959641/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,36416879,Resolvin D1 modulates periodontal ligament fibroblast function.,2023,10.1002/jper.22-0462,https://pubmed.ncbi.nlm.nih.gov/36416879/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,37242769,Lung Inflammation Resolution by RvD1 and RvD2 in a Receptor-Dependent Manner.,2023,10.3390/pharmaceutics15051527,https://pubmed.ncbi.nlm.nih.gov/37242769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,34907914,Proresolving receptor tames inflammation in atherosclerosis.,2021,10.1172/jci155240,https://pubmed.ncbi.nlm.nih.gov/34907914/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,37925045,Lipoxin-mediated signaling: ALX/FPR2 interaction and beyond.,2023,10.1016/j.phrs.2023.106982,https://pubmed.ncbi.nlm.nih.gov/37925045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,34162770,Specialized Proresolving Mediators for Therapeutic Interventions Targeting Metabolic and Inflammatory Disorders.,2021,10.4062/biomolther.2021.094,https://pubmed.ncbi.nlm.nih.gov/34162770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,34847389,Specialized pro-resolving receptors are expressed in salivary glands with Sjögren's syndrome.,2022,10.1016/j.anndiagpath.2021.151865,https://pubmed.ncbi.nlm.nih.gov/34847389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,37721095,Effects of polyunsaturated fatty acid supplementation on plasma and follicular fluid resolvin D1 concentration and mRNA abundance in granulosa cells in ewes.,2023,10.1093/jas/skad310,https://pubmed.ncbi.nlm.nih.gov/37721095/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,32670289,Distinct Profiles of Specialized Pro-resolving Lipid Mediators and Corresponding Receptor Gene Expression in Periodontal Inflammation.,2020,10.3389/fimmu.2020.01307,https://pubmed.ncbi.nlm.nih.gov/32670289/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,31562618,Immunoresolvent Resolvin D1 Maintains the Health of the Ocular Surface.,2019,10.1007/978-3-030-21735-8_3,https://pubmed.ncbi.nlm.nih.gov/31562618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,30487747,Lipoxin and Resolvin Receptors Transducing the Resolution of Inflammation in Cardiovascular Disease.,2018,10.3389/fphar.2018.01273,https://pubmed.ncbi.nlm.nih.gov/30487747/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,33324446,Multi-Omics Analysis Reveals Novel Subtypes and Driver Genes in Glioblastoma.,2020,10.3389/fgene.2020.565341,https://pubmed.ncbi.nlm.nih.gov/33324446/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,32259091,New Advances in Targeting the Resolution of Inflammation: Implications for Specialized Pro-Resolving Mediator GPCR Drug Discovery.,2020,10.1021/acsptsci.9b00075,https://pubmed.ncbi.nlm.nih.gov/32259091/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,32317985,Resolvin D1 Protects Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Increasing Treg Percentages via the ALX/FPR2 Pathway.,2020,10.3389/fphys.2020.00285,https://pubmed.ncbi.nlm.nih.gov/32317985/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,27559094,"Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses.",2016,10.1126/scitranslmed.aaf7483,https://pubmed.ncbi.nlm.nih.gov/27559094/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,30052486,Resolution of inflammation is altered in chronic heart failure and entails a dysfunctional responsiveness of T lymphocytes.,2019,10.1096/fj.201801017r,https://pubmed.ncbi.nlm.nih.gov/30052486/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,29563331,Pro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli-driven acute inflammation.,2018,10.1172/jci.insight.94463,https://pubmed.ncbi.nlm.nih.gov/29563331/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,24588652,"Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7.",2014,10.1111/bph.12665,https://pubmed.ncbi.nlm.nih.gov/24588652/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,28079976,Maresin 1 induces a novel pro-resolving phenotype in human platelets.,2017,10.1111/jth.13620,https://pubmed.ncbi.nlm.nih.gov/28079976/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,23462912,Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion.,2013,10.1038/mi.2013.7,https://pubmed.ncbi.nlm.nih.gov/23462912/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,23186989,"1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients.",2013,10.3233/jad-121735,https://pubmed.ncbi.nlm.nih.gov/23186989/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR32,ENSG00000142511,Unsafe,26969756,Resolvin D1 Polarizes Primary Human Macrophages toward a Proresolution Phenotype through GPR32.,2016,10.4049/jimmunol.1501701,https://pubmed.ncbi.nlm.nih.gov/26969756/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,42903481,15-hydroxyeicosatetraenoic acid (15-HETE)-GPR39 axis: a potential therapeutic target in eosinophilic asthma.,2026,10.3389/fphar.2026.1880829,https://pubmed.ncbi.nlm.nih.gov/42903481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,41851960,"Synthesis, Radiochemistry, and Preclinical Assessment of the First GPR39 PET Imaging Agent.",2026,10.1021/acs.jmedchem.5c03351,https://pubmed.ncbi.nlm.nih.gov/41851960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,41784884,Obestatin: canonical and unexpected functions.,2026,10.1007/s11154-026-10021-0,https://pubmed.ncbi.nlm.nih.gov/41784884/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,42615414,Selective pharmacological blockade of GPR39 markedly reduces no-reflow and infarct volumes in rat acute myocardial infarction when administered before reperfusion.,2026,10.1152/ajpheart.01008.2025,https://pubmed.ncbi.nlm.nih.gov/42615414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,42274610,Zinc Signaling in Acute Kidney Injury.,2026,10.3390/cells15111018,https://pubmed.ncbi.nlm.nih.gov/42274610/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,42786606,15-Hydroxyeicosatetraenoic Acid and G-Protein Coupled Receptor 39 Together Orchestrate Coronary Autoregulation: A Comprehensive Metabolomic Analysis.,2026,10.1161/jaha.125.048864,https://pubmed.ncbi.nlm.nih.gov/42786606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,42162244,Enhanced expression of spinal PTP1B contributes to peripheral inflammation- induced glycinergic disinhibition and mechanical pain.,2026,10.1038/s42003-026-10318-5,https://pubmed.ncbi.nlm.nih.gov/42162244/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,42572499,GPR39 Suppresses Ferroptosis via the Nrf2/SLC7A11 Axis and Reduces the Sensitivity of Colorectal Cancer to Anti-PD-1 Immunotherapy.,2026,10.1155/cjgh/5689742,https://pubmed.ncbi.nlm.nih.gov/42572499/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,41651415,GPR39-mediated molecular signaling by bile acids.,2026,10.1016/j.jbc.2026.111241,https://pubmed.ncbi.nlm.nih.gov/41651415/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,42888346,"A genome-wide association study of cognitive impairment in a Chinese cohort of 1,040 individuals.",2026,10.1007/s00439-026-02887-6,https://pubmed.ncbi.nlm.nih.gov/42888346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,41041978,"The Role of GPR39 in Regulating Osteoblast Function, Bone Matrix Quality, and Gender-Specific Bone Homeostasis.",2025,10.1002/jcp.70095,https://pubmed.ncbi.nlm.nih.gov/41041978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,41117931,TPEN attenuates neuronal ferroptosis in ischemic brain injury via GPR39-mediated PI3K/AKT signaling activation.,2025,10.1080/01616412.2025.2578343,https://pubmed.ncbi.nlm.nih.gov/41117931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,41494658,GPR39 activation inhibits AQP2 trafficking and alters cytoskeletal organization.,2026,10.1152/ajpcell.00748.2025,https://pubmed.ncbi.nlm.nih.gov/41494658/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,40017509,"The zinc receptor, ZnR/GPR39, modulates taste sensitivity by regulating ion secretion in mouse salivary gland.",2025,10.1016/j.isci.2025.111912,https://pubmed.ncbi.nlm.nih.gov/40017509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,41996347,Novel Roles of GPCRs in the Renal Collecting Duct.,2026,10.1152/physiol.00005.2026,https://pubmed.ncbi.nlm.nih.gov/41996347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,41541654,Obestatin Treatment Counteracts Muscle Wasting by Reactivation of Autophagy in Duchenne Muscular Dystrophy.,2026,10.1002/mco2.70563,https://pubmed.ncbi.nlm.nih.gov/41541654/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,40499698,Orphan receptor GPR39: A potential therapeutic target for inflammatory diseases.,2025,10.1016/j.gene.2025.149625,https://pubmed.ncbi.nlm.nih.gov/40499698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,39581978,"Loss of the zinc receptor ZnR/GPR39 in mice enhances anxiety-related behavior and motor deficits, and modulates KCC2 expression in the amygdala.",2024,10.1186/s12993-024-00254-x,https://pubmed.ncbi.nlm.nih.gov/39581978/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,41508425,The role of zinc homeostasis in major depressive disorder: heterogeneous pathological mechanisms and therapeutic implications.,2026,10.1080/07853890.2025.2611191,https://pubmed.ncbi.nlm.nih.gov/41508425/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,40026072,Zinc Alleviates Diabetic Muscle Atrophy via Modulation of the SIRT1/FoxO1 Autophagy Pathway Through GPR39.,2025,10.1002/jcsm.13771,https://pubmed.ncbi.nlm.nih.gov/40026072/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,39500998,Targeting GPR39 in structure-based drug discovery reduces Ang II-induced hypertension.,2024,10.1038/s42003-024-07132-2,https://pubmed.ncbi.nlm.nih.gov/39500998/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,40172982,Renal Ghrelin-Family GPR39 Receptor and Urinary Concentrating Ability.,2025,10.1681/asn.0000000687,https://pubmed.ncbi.nlm.nih.gov/40172982/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,40827131,An Agonist of Zinc-Sensing G-Protein Coupled Receptor 39 Accelerates Skin Wound Healing and Protects Against UVB-Induced Keratinocyte Damage.,2025,10.2147/jep.s531431,https://pubmed.ncbi.nlm.nih.gov/40827131/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,39684342,The GPR39 Receptor Plays an Important Role in the Pathogenesis of Overactive Bladder and Corticosterone-Induced Depression.,2024,10.3390/ijms252312630,https://pubmed.ncbi.nlm.nih.gov/39684342/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,40842347,Ultrafast Tyrosinase-Mediated Biotinylation of Living Cell Surface Analysis Reveals Novel Cell Surface Proteins Responsible for Influenza A Virus Entry.,2025,10.1021/jacs.5c12360,https://pubmed.ncbi.nlm.nih.gov/40842347/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,38306424,GPR39 regulated spinal glycinergic inhibition and mechanical inflammatory pain.,2024,10.1126/sciadv.adj3808,https://pubmed.ncbi.nlm.nih.gov/38306424/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,35357432,Activation of the zinc-sensing receptor GPR39 promotes T-cell reconstitution after hematopoietic cell transplant in mice.,2022,10.1182/blood.2021013950,https://pubmed.ncbi.nlm.nih.gov/35357432/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,36942516,Signaling pathway mechanisms of neurological diseases induced by G protein-coupled receptor 39.,2023,10.1111/cns.14174,https://pubmed.ncbi.nlm.nih.gov/36942516/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,36292986,Functions of the Zinc-Sensing Receptor GPR39 in Regulating Intestinal Health in Animals.,2022,10.3390/ijms232012133,https://pubmed.ncbi.nlm.nih.gov/36292986/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,38599157,GPR39-mediated ERK1/2 signaling reduces permethrin-induced proliferation of estrogen receptor α-negative cells.,2024,10.1016/j.ecoenv.2024.116303,https://pubmed.ncbi.nlm.nih.gov/38599157/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,37185787,TC-G 1008 facilitates epileptogenesis by acting selectively at the GPR39 receptor but non-selectively activates CREB in the hippocampus of pentylenetetrazole-kindled mice.,2023,10.1007/s00018-023-04766-z,https://pubmed.ncbi.nlm.nih.gov/37185787/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,42269381,International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors.,2026,10.1016/j.pharmr.2026.100141,https://pubmed.ncbi.nlm.nih.gov/42269381/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,35875352,GPR39 Deficiency Impairs Memory and Alters Oxylipins and Inflammatory Cytokines Without Affecting Cerebral Blood Flow in a High-Fat Diet Mouse Model of Cognitive Impairment.,2022,10.3389/fncel.2022.893030,https://pubmed.ncbi.nlm.nih.gov/35875352/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,38540076,Dietary Zn Deficiency Inhibits Cell Proliferation via the GPR39-Mediated Suppression of the PI3K/AKT/mTOR Signaling Pathway in the Jejunum of Broilers.,2024,10.3390/ani14060979,https://pubmed.ncbi.nlm.nih.gov/38540076/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR39,ENSG00000183840,Unsafe,9441746,Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors.,1997,10.1006/geno.1997.5069,https://pubmed.ncbi.nlm.nih.gov/9441746/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,42662813,GPR55 Inhibits Inflammatory Factor TNF-α-Mediated RhoA/ROCK2/IκBα/p65 Signaling Pathway to Alleviate Diabetic Cardiomyopathy in Rats.,2026,10.2147/ijgm.s624354,https://pubmed.ncbi.nlm.nih.gov/42662813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,42568689,GPR55 and PINK1 as emerging therapeutic targets in Glioma: insights into their modulation by phytochemicals and plant extracts.,2026,10.3389/fphar.2026.1760169,https://pubmed.ncbi.nlm.nih.gov/42568689/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,41957642,Astrocytic GPR55 receptors promote glycolysis.,2026,10.1186/s42238-026-00407-x,https://pubmed.ncbi.nlm.nih.gov/41957642/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,42756304,GPR55 deletion increases anxiety- and depression-like behaviors and modifies amygdalar GABA&lt;sub&gt;A&lt;/sub&gt;α2 expression.,2026,10.3389/fphar.2026.1766492,https://pubmed.ncbi.nlm.nih.gov/42756304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,41823054,"Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions.",2026,10.1111/liv.70576,https://pubmed.ncbi.nlm.nih.gov/41823054/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,41981055,Activating GPR55 protects cochlear hair cells against cisplatin-induced ototoxicity via inhibiting MAPK pathway.,2026,10.1038/s41598-026-48548-6,https://pubmed.ncbi.nlm.nih.gov/41981055/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,41394912,"Cannabinoid and cannabinoid related receptors in fibroblasts, inflammatory and endothelial cells of the equine hoof with and without laminitis: novel pharmacological target.",2025,10.3389/fvets.2025.1723160,https://pubmed.ncbi.nlm.nih.gov/41394912/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,41424074,Endocannabinoid system gene expression in mesocorticolimbic brain regions of individuals with alcohol use disorder: A descriptive study.,2026,10.1111/add.70293,https://pubmed.ncbi.nlm.nih.gov/41424074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,42078490,Modulation of the endocannabinoid system reduces inflammatory signalling in canine mammary carcinoma cells.,2026,10.1002/vro2.70034,https://pubmed.ncbi.nlm.nih.gov/42078490/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,41836312,Coactivation of CB1 and GPR55 promotes GABA release and motor behavior at striatonigral terminals through increased dimerization induced by CB1 activation.,2026,10.3389/fnmol.2026.1717829,https://pubmed.ncbi.nlm.nih.gov/41836312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,42475352,Chronic CBD treatment differentially modulates neurobehavioral outcomes and endocannabinoid signaling in an aged HIV-1 Tat transgenic mouse model.,2026,10.1371/journal.pone.0353267,https://pubmed.ncbi.nlm.nih.gov/42475352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,42284890,Role of GPR55 in glutamatergic and dopaminergic signaling: A review of preclinical evidence in neuropsychiatric disorders.,2026,10.1016/j.molpha.2026.100131,https://pubmed.ncbi.nlm.nih.gov/42284890/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,41945640,Increased reluctant vesicles underlie synaptic depression by GPR55 in axon terminals of rat cerebellar Purkinje cells.,2026,10.7554/elife.105268,https://pubmed.ncbi.nlm.nih.gov/41945640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,42661811,"Depression of synaptic outputs by reduction of Ca&lt;sup&gt;2+&lt;/sup&gt; influx, but not RRP vesicles, becomes evident upon CB2R hyper-expression at cerebellar Purkinje cell terminals.",2026,10.3389/fnmol.2026.1842304,https://pubmed.ncbi.nlm.nih.gov/42661811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,41776092,Neuroprotective Role of Cannabinoid CB&lt;sub&gt;1&lt;/sub&gt; and GPR55 Receptors in a Cell Model of Multiple Sclerosis.,2026,10.1007/s12035-026-05780-5,https://pubmed.ncbi.nlm.nih.gov/41776092/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,41005974,Decreased GPR55 expression links B-cell activation and vascular remodelling in atherosclerosis in patients with early rheumatoid arthritis.,2025,10.1136/rmdopen-2025-005820,https://pubmed.ncbi.nlm.nih.gov/41005974/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,41407043,GPR55 deficiency exacerbates cognitive impairments and Alzheimer's disease-like pathology in mice.,2026,10.1016/j.neuint.2025.106105,https://pubmed.ncbi.nlm.nih.gov/41407043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,42555531,An agonist of the cannabinoid-sensing G-protein coupled receptor 55 promotes wound healing and protects against UVB-induced keratinocyte damage.,2026,10.1080/21688370.2026.2713791,https://pubmed.ncbi.nlm.nih.gov/42555531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,42203173,Intestinal colonization of germ-free mice with indole-producing E. coli modulates the central and peripheral endocannabinoidome.,2026,10.1016/j.jlr.2026.101070,https://pubmed.ncbi.nlm.nih.gov/42203173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,42572649,Emerging roles of cannabinoid pathways in renal injury and repair.,2026,10.3389/fphar.2026.1777644,https://pubmed.ncbi.nlm.nih.gov/42572649/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,42418020,GPR55 negatively regulates CD8&lt;sup&gt;+&lt;/sup&gt; intraepithelial lymphocyte migration dynamics in oral lichen planus.,2026,10.1007/s10735-026-10889-x,https://pubmed.ncbi.nlm.nih.gov/42418020/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,39885986,GPR55 in the tumor microenvironment of pancreatic cancer controls tumorigenesis.,2024,10.3389/fimmu.2024.1513547,https://pubmed.ncbi.nlm.nih.gov/39885986/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,42653650,Neuropharmacology of Cannabinoids: A Comprehensive Review of Preclinical and Clinical Evidence for Hemp-Derived Extracts and Active Compounds.,2026,10.3390/ph19081151,https://pubmed.ncbi.nlm.nih.gov/42653650/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,42039760,Mixed squaramide thioesters as phosphate group analogues for non-competitive antagonists of the phospholipid-sensing G protein-coupled receptor GPR55.,2026,10.1039/d5cb00231a,https://pubmed.ncbi.nlm.nih.gov/42039760/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,42424869,"Cannabidiol and epilepsy: therapeutic, mechanistic and clinical significance.",2026,10.1016/j.seizure.2026.06.014,https://pubmed.ncbi.nlm.nih.gov/42424869/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,41257868,"Cannabidiol in pancreatic ductal adenocarcinoma: preclinical evidence, molecular mechanisms, and translational challenges.",2025,10.1186/s12935-025-04062-9,https://pubmed.ncbi.nlm.nih.gov/41257868/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,40565152,"Evaluating the Antitumor Potential of Cannabichromene, Cannabigerol, and Related Compounds from &lt;i&gt;Cannabis sativa&lt;/i&gt; and &lt;i&gt;Piper nigrum&lt;/i&gt; Against Malignant Glioma: An In Silico to In Vitro Approach.",2025,10.3390/ijms26125688,https://pubmed.ncbi.nlm.nih.gov/40565152/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,42797481,Neurotoxicity of Synthetic Cannabinoid Receptor Agonist Cumyl-PINACA: An In Vitro Study on Rat Cortical Neurons and Astrocytes.,2026,10.3390/ph19091436,https://pubmed.ncbi.nlm.nih.gov/42797481/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,40429822,GPR55 Antagonist CID16020046 Suppresses Collagen-Induced Rheumatoid Arthritis by Suppressing Th1/Th17 Cells in Mice.,2025,10.3390/ijms26104680,https://pubmed.ncbi.nlm.nih.gov/40429822/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,41463324,"Pharmacological and Pharmacokinetic Profile of Cannabidiol in Human Epilepsy: A Review of Metabolism, Therapeutic Drug Monitoring, and Interactions with Antiseizure Medications.",2025,10.3390/biom15121668,https://pubmed.ncbi.nlm.nih.gov/41463324/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,41242751,LPC18:0 Secreted by Exogenous Neural Stem Cells Potentiates Neurogenesis and Functional Recovery via GPR55-Mediated Signalling in Spinal Cord Injury.,2026,10.1111/cpr.70146,https://pubmed.ncbi.nlm.nih.gov/41242751/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,37688769,A comprehensive survival and prognosis analysis of GPR55 expression in hepatocellular carcinoma.,2023,10.18632/aging.205008,https://pubmed.ncbi.nlm.nih.gov/37688769/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,37544935,Lysophosphatidylglucoside/GPR55 signaling promotes foam cell formation in human M2c macrophages.,2023,10.1038/s41598-023-39904-x,https://pubmed.ncbi.nlm.nih.gov/37544935/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,36523570,GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation.,2022,10.1038/s44161-022-00155-0,https://pubmed.ncbi.nlm.nih.gov/36523570/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,19805329,The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo.,2009,10.1073/pnas.0902743106,https://pubmed.ncbi.nlm.nih.gov/19805329/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR55,ENSG00000135898,Unsafe,9931487,"Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain.",1999,10.1016/s0169-328x(98)00277-0,https://pubmed.ncbi.nlm.nih.gov/9931487/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR89B,ENSG00000188092,Unsafe,40695280,Human-specific gene expansions contribute to brain evolution.,2025,10.1016/j.cell.2025.06.037,https://pubmed.ncbi.nlm.nih.gov/40695280/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR89B,ENSG00000188092,Unsafe,32554864,Serum exosomal long noncoding RNAs lnc-FAM72D-3 and lnc-EPC1-4 as diagnostic biomarkers for hepatocellular carcinoma.,2020,10.18632/aging.103355,https://pubmed.ncbi.nlm.nih.gov/32554864/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR89B,ENSG00000188092,Unsafe,30342663,Prenatal diagnosis of a familial 1q21.1-q21.2 microdeletion in a fetus with polydactyly of left foot on prenatal ultrasound.,2018,10.1016/j.tjog.2018.08.024,https://pubmed.ncbi.nlm.nih.gov/30342663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR89B,ENSG00000188092,Unsafe,31759543,Detection of a familial 1q21.1 microdeletion and concomitant CHD1L mutation in a fetus with oligohydramnios and bilateral renal dysplasia on prenatal ultrasound.,2019,10.1016/j.tjog.2019.07.031,https://pubmed.ncbi.nlm.nih.gov/31759543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GPR89B,ENSG00000188092,Unsafe,18794847,GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus.,2008,10.1038/ncb1773,https://pubmed.ncbi.nlm.nih.gov/18794847/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,42477371,Identification of a novel glutamate receptor 2 mutation in mice presenting progressive cerebellar ataxia.,2026,10.1038/s41598-026-62082-5,https://pubmed.ncbi.nlm.nih.gov/42477371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,41151789,Chorea in a Patient With GRID2-Related Disorder: Expanding the Phenotypic Spectrum Beyond Cerebellar Ataxia and Tonic Upgaze.,2026,10.14802/jmd.25205,https://pubmed.ncbi.nlm.nih.gov/41151789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,41371357,Peripheral GRID2 DNA methylation as a diagnostic biomarker for adolescent depression: Linking self-compassion to glutamatergic epigenetic changes.,2026,10.1016/j.jad.2025.120861,https://pubmed.ncbi.nlm.nih.gov/41371357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,40897174,Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth.,2025,10.1016/j.neuron.2025.08.005,https://pubmed.ncbi.nlm.nih.gov/40897174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,42137963,Comprehensive profiling and molecular characterization of alternative splicing regulation in synaptic remodelling associated with neuropathic pain induced by chronic constrictive injury in a rat model.,2026,10.1080/15476286.2026.2675080,https://pubmed.ncbi.nlm.nih.gov/42137963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,41327020,Integrated ATAC-seq and RNA-seq analysis identifies Grid2 and Reln as potential regulatory genes in migraine pathophysiology.,2025,10.1186/s10194-025-02228-4,https://pubmed.ncbi.nlm.nih.gov/41327020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,39312122,De Novo GRID2 Variant as a Cause of Ataxia with Oculomotor Apraxia and Alpha-Fetoprotein Elevation.,2024,10.1007/s12311-024-01743-5,https://pubmed.ncbi.nlm.nih.gov/39312122/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,41930175,Comprehensive Bioinformatics Analysis and Experimental Verification RNF186 Is a Recurrence Signature Gene of Hepatocellular Carcinoma that Promotes Cell Proliferation.,2026,10.32604/or.2026.071617,https://pubmed.ncbi.nlm.nih.gov/41930175/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,42774553,A comprehensive overview of genetic mutations in Iranian patients with Bardet-Biedl syndrome.,2026,10.1016/j.ymgmr.2026.101357,https://pubmed.ncbi.nlm.nih.gov/42774553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,40981016,Potential Benefits of a Noninvasive Neuromodulation Protocol in Autism Spectrum Disorder with Multiple Comorbidities: A Case Report.,2025,10.3390/pediatric17050092,https://pubmed.ncbi.nlm.nih.gov/40981016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,37944084,"Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants.",2024,10.1093/hmg/ddad188,https://pubmed.ncbi.nlm.nih.gov/37944084/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,40281964,Molecular Mechanism of the &lt;i&gt;Grid&lt;/i&gt; Gene Family Regulating Growth Size Heteromorphism in &lt;i&gt;Cynoglossus semilaevis&lt;/i&gt;.,2025,10.3390/ani15081130,https://pubmed.ncbi.nlm.nih.gov/40281964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,35159210,"Neurodevelopmental Syndrome with Intellectual Disability, Speech Impairment, and Quadrupedia Is Associated with Glutamate Receptor Delta 2 Gene Defect.",2022,10.3390/cells11030400,https://pubmed.ncbi.nlm.nih.gov/35159210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,37964339,Grid2 interacting protein is a potential biomarker related to immune infiltration in colorectal cancer.,2023,10.1186/s40001-023-01468-x,https://pubmed.ncbi.nlm.nih.gov/37964339/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,42589016,Effects of the Temperature-Humidity Index on Milk Production Traits and Gene-Environment Interactions in Chinese Holstein Cows.,2026,10.3390/ani16152379,https://pubmed.ncbi.nlm.nih.gov/42589016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,36162328,GRID2 aberration leads to disturbance in neuroactive ligand-receptor interactions via changes to the species richness and composition of gut microbes.,2022,10.1016/j.bbrc.2022.09.006,https://pubmed.ncbi.nlm.nih.gov/36162328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,39325889,Cross-species single-cell spatial transcriptomic atlases of the cerebellar cortex.,2024,10.1126/science.ado3927,https://pubmed.ncbi.nlm.nih.gov/39325889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,37459550,Mycoplasma DnaK increases DNA copy number variants in vivo.,2023,10.1073/pnas.2219897120,https://pubmed.ncbi.nlm.nih.gov/37459550/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,38986358,"Whole genome resequencing reveals the adaptability of native chickens to drought, tropical and frigid environments in Xinjiang.",2024,10.1016/j.psj.2024.103947,https://pubmed.ncbi.nlm.nih.gov/38986358/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,40658082,"Genomic Insights into the Origin, High Fecundity and Environmental Adaptation of Hu Sheep.",2025,10.1002/advs.202506492,https://pubmed.ncbi.nlm.nih.gov/40658082/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,37344884,Whole genome sequencing across clinical trials identifies rare coding variants in GPR68 associated with chemotherapy-induced peripheral neuropathy.,2023,10.1186/s13073-023-01193-4,https://pubmed.ncbi.nlm.nih.gov/37344884/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,34746127,Identification of an Autophagy-Related Risk Signature Correlates With Immunophenotype and Predicts Immune Checkpoint Blockade Efficacy of Neuroblastoma.,2021,10.3389/fcell.2021.731380,https://pubmed.ncbi.nlm.nih.gov/34746127/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,38397218,Identification of Candidate Genes and Pathways Linked to the Temperament Trait in Sheep.,2024,10.3390/genes15020229,https://pubmed.ncbi.nlm.nih.gov/38397218/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,36660425,An integrated analysis of prognostic mRNA signature in early- and progressive-stage gastric adenocarcinoma.,2022,10.3389/fmolb.2022.1022056,https://pubmed.ncbi.nlm.nih.gov/36660425/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,37830614,"In Cerebellar Atrophy of 12-Month-Old ATM-Null Mice, Transcriptome Upregulations Concern Most Neurotransmission and Neuropeptide Pathways, While Downregulations Affect Prominently Itpr1, Usp2 and Non-Coding RNA.",2023,10.3390/cells12192399,https://pubmed.ncbi.nlm.nih.gov/37830614/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,36419462,Thyroid hormone elicits intergenerational epigenetic effects on adult social behavior and fetal brain expression of autism susceptibility genes.,2022,10.3389/fnins.2022.1055116,https://pubmed.ncbi.nlm.nih.gov/36419462/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,36210389,An eleven autophagy-related genes-based prognostic signature for endometrial carcinoma.,2022,10.1186/s43046-022-00135-2,https://pubmed.ncbi.nlm.nih.gov/36210389/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,29782851,Glycosylation of Cblns attenuates their receptor binding.,2018,10.1016/j.brainres.2018.05.022,https://pubmed.ncbi.nlm.nih.gov/29782851/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,36230283,Genome-Wide Association Study for Udder Conformation Traits in Chinese Holstein Cattle.,2022,10.3390/ani12192542,https://pubmed.ncbi.nlm.nih.gov/36230283/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,35701443,Deletion in chromosome 6 spanning alpha-synuclein and multimerin1 loci in the Rab27a/b double knockout mouse.,2022,10.1038/s41598-022-13557-8,https://pubmed.ncbi.nlm.nih.gov/35701443/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,38075686,A genome-wide association study reveals novel SNP markers associated with resilience traits in two Mediterranean dairy sheep breeds.,2023,10.3389/fgene.2023.1294573,https://pubmed.ncbi.nlm.nih.gov/38075686/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,34790823,Identification of Autophagy-Related Prognostic Signature and Analysis of Immune Cell Infiltration in Low-Grade Gliomas.,2021,10.1155/2021/7918693,https://pubmed.ncbi.nlm.nih.gov/34790823/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,34335109,Prognostic Signature of Osteosarcoma Based on 14 Autophagy-Related Genes.,2021,10.3389/pore.2021.1609782,https://pubmed.ncbi.nlm.nih.gov/34335109/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRID2,ENSG00000152208,Unsafe,30883267,A systematic review of genome-wide association studies of antipsychotic response.,2019,10.2217/pgs-2018-0163,https://pubmed.ncbi.nlm.nih.gov/30883267/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,42450213,Glutamate Ionotropic Kainate Receptors as Therapeutic Targets in Enzalutamide-Resistant and Neuroendocrine Prostate Cancer.,2026,10.3390/ijms27135945,https://pubmed.ncbi.nlm.nih.gov/42450213/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,42184490,GRIK2 drives LUAD progression via the cAMP/PKA/CREB pathway.,2026,10.1016/j.tice.2026.103622,https://pubmed.ncbi.nlm.nih.gov/42184490/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,41917044,Trisomy 21 Drives ADARB1 Overexpression and Premature RNA Recoding in the Developing Fetal Brain.,2026,10.1038/s41467-026-70217-5,https://pubmed.ncbi.nlm.nih.gov/41917044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,41905875,Thermal Stress-Induced Alterations to Oxylipin Signal Receptors in the Cnidarian-Dinoflagellate Symbiosis.,2026,10.1111/1462-2920.70269,https://pubmed.ncbi.nlm.nih.gov/41905875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,42737835,Sarcosine Remodels DNA Methylation-Linked Transcriptional Networks During Epileptogenesis in the Rat Rapid Hippocampal Kindling Model.,2026,10.3390/ijms27177938,https://pubmed.ncbi.nlm.nih.gov/42737835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,41327126,Association between GRIK1 rs363598 and intergenic rs360932 variants and susceptibility to autism spectrum disorders in Egyptian children.,2025,10.1186/s12887-025-06229-9,https://pubmed.ncbi.nlm.nih.gov/41327126/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,41391686,Pathological gain-of-function human variants in the GRIK2 kainate receptor gene cause wide-ranging behavioral dysfunction and seizures in mouse models.,2026,10.1016/j.nbd.2025.107226,https://pubmed.ncbi.nlm.nih.gov/41391686/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,40694278,Microarray and Single-Cell RNA Sequencing Reveals G-Protein Gene Expression Signatures of Spermatogonia Stem Cell.,2025,10.1007/s12015-025-10942-4,https://pubmed.ncbi.nlm.nih.gov/40694278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,42317296,"Social isolation during adolescence alters novel object recognition memory, brain and gut gene expression, and microbiota composition in a sex-specific manner.",2026,10.1016/j.bbih.2026.101284,https://pubmed.ncbi.nlm.nih.gov/42317296/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,42820876,Left Stellate Ganglion Pulsed Radiofrequency Suppresses Ischemic Ventricular Arrhythmias: A Translational Study.,2026,10.1016/j.jacep.2026.08.019,https://pubmed.ncbi.nlm.nih.gov/42820876/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,42833504,Antidepressant treatment alters both suicide-candidate gene expression levels and mitochondrial bioenergetic function in human microglial HMC3 cell line.,2026,10.1016/j.pnpbp.2026.111961,https://pubmed.ncbi.nlm.nih.gov/42833504/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,39614348,ASXL1 truncating variants in BOS and myeloid leukemia drive shared disruption of Wnt-signaling pathways but have differential isoform usage of RUNX3.,2024,10.1186/s12920-024-02039-7,https://pubmed.ncbi.nlm.nih.gov/39614348/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,39429724,A novel AAV9-dual microRNA-vector targeting GRIK2 in the hippocampus as a treatment for mesial temporal lobe epilepsy.,2024,10.1016/j.omtm.2024.101342,https://pubmed.ncbi.nlm.nih.gov/39429724/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,40295836,Ursolic acid derivative UA312 ameliorates ionizing radiation-induced cardiotoxicity and neurodevelopmental toxicity in zebrafish via targeting chrna3 and grik5.,2025,10.1038/s41401-025-01564-0,https://pubmed.ncbi.nlm.nih.gov/40295836/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,40295632,Single-nucleus RNA sequencing reveals a preclinical model for the most common subtype of glioblastoma.,2025,10.1038/s42003-025-08092-x,https://pubmed.ncbi.nlm.nih.gov/40295632/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,38590740,GRIK phosphorylates and activates KIN10 which also promotes its degradation.,2024,10.3389/fpls.2024.1375471,https://pubmed.ncbi.nlm.nih.gov/38590740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,40943499,Neurotransmitter Genes in the Nucleus Accumbens That Are Involved in the Development of a Behavioral Pathology After Positive Fighting Experiences and Their Deprivation: A Conceptual Paradigm for Data Analysis.,2025,10.3390/ijms26178580,https://pubmed.ncbi.nlm.nih.gov/40943499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,40527340,Influence of Glutamate Neurotransmission Genes on the Outcomes of Antipsychotic Treatments.,2025,10.1055/a-2603-0871,https://pubmed.ncbi.nlm.nih.gov/40527340/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,41408324,HDAC2 as a therapeutic target in bladder cancer: insights into the altered epigenetic regulation and lysine lactylation.,2025,10.1186/s13046-025-03610-5,https://pubmed.ncbi.nlm.nih.gov/41408324/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,40103938,Gene mutations linked to drug-resistant epilepsy in astrocytoma.,2025,10.3389/fneur.2025.1523468,https://pubmed.ncbi.nlm.nih.gov/40103938/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,40702505,Determination of high-grade serous ovarian cancer stem cell-based subtypes and prognostic model and identification of highly expressed VSIG4 and STAB1 in macrophages.,2025,10.1186/s13048-025-01747-7,https://pubmed.ncbi.nlm.nih.gov/40702505/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,42278079,Genomic Signatures of Selection Reveal Breed-Specific and Shared Adaptive Regions in South African Beef Cattle.,2026,10.3390/ani16111645,https://pubmed.ncbi.nlm.nih.gov/42278079/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,38535448,Differential Proteomic Analysis of Low-Dose Chronic Paralytic Shellfish Poisoning.,2024,10.3390/md22030108,https://pubmed.ncbi.nlm.nih.gov/38535448/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,39022075,"A novel signature of seven aging-related genes for risk stratification, prognosis prediction and benefit evaluation of chemotherapy, and immunotherapy in elderly patients with lung adenocarcinoma.",2024,10.1016/j.heliyon.2024.e33268,https://pubmed.ncbi.nlm.nih.gov/39022075/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,34405274,GRIK2 is a target for bladder cancer stem-like cell-targeting immunotherapy.,2022,10.1007/s00262-021-03025-z,https://pubmed.ncbi.nlm.nih.gov/34405274/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,34872356,A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency.,2021,10.1128/mbio.02980-21,https://pubmed.ncbi.nlm.nih.gov/34872356/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,38099288,Neurotransmitter receptor-related gene signature as potential prognostic and therapeutic biomarkers in colorectal cancer.,2023,10.3389/fcell.2023.1202193,https://pubmed.ncbi.nlm.nih.gov/38099288/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,36686818,Alternative splicing event associated with immunological features in bladder cancer.,2022,10.3389/fonc.2022.966088,https://pubmed.ncbi.nlm.nih.gov/36686818/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIK5,ENSG00000105737,Unsafe,37968596,Changes in ADAR RNA editing patterns in CMV and ZIKV congenital infections.,2023,10.1186/s12864-023-09778-4,https://pubmed.ncbi.nlm.nih.gov/37968596/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,41255364,Gastric bypass surgery improves lipid metabolism and mitochondrial function through the glutamate receptor Grin3a-mediated CaMKKβ/AMPK pathway in a rat model of type 2 diabetes.,2026,10.1111/dme.70170,https://pubmed.ncbi.nlm.nih.gov/41255364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,42298735,Integrating machine learning and retrospective cohort to explore the effects of AEDs on the prognosis of LGG and identify related molecular targets.,2026,10.1186/s40360-026-01167-3,https://pubmed.ncbi.nlm.nih.gov/42298735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,41642561,GRIN3A defines an immunosuppressive niche in advanced prostate cancer.,2026,10.1007/s12032-026-03244-3,https://pubmed.ncbi.nlm.nih.gov/41642561/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,41011178,Isoliquiritigenin as a Neuronal Radiation Mitigant: Mitigating Radiation-Induced Anhedonia Tendency Targeting Grik3/Grm8/Grin3a via Integrated Proteomics and AI-Driven Discovery.,2025,10.3390/ph18091307,https://pubmed.ncbi.nlm.nih.gov/41011178/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,41693787,Integrating network pharmacology and transcriptomics to reveal the therapeutic effect of Long Mu Ning Xin Decoction on attention-deficit/hyperactivity disorder by regulating cAMP and PI3K/AKT pathways.,2026,10.3389/fphar.2026.1744709,https://pubmed.ncbi.nlm.nih.gov/41693787/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,39396906,Hippocampal tau-induced GRIN3A deficiency in Alzheimer's disease.,2024,10.1002/2211-5463.13904,https://pubmed.ncbi.nlm.nih.gov/39396906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,41303586,"Dose-Dependent Effects of Myo-Inositol on Kainic Acid-Induced Epilepsy: Electrophysiological, Behavioral, Transcriptomic, and DNA Methylome Studies.",2025,10.3390/ijms262211102,https://pubmed.ncbi.nlm.nih.gov/41303586/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,42150879,GluN3A Is Required for Coordinated Postnatal Development of Axonal and Dendritic Branching Patterns in Mouse L2/3 Callosal Projection Neurons.,2026,10.1523/jneurosci.0156-25.2026,https://pubmed.ncbi.nlm.nih.gov/42150879/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,41720779,Genetic modifiers of APOE-ε4-associated cognitive decline.,2026,10.1038/s41467-026-68933-z,https://pubmed.ncbi.nlm.nih.gov/41720779/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,38944914,GRIN3A: A biomarker associated with a cribriform pattern and poor prognosis in prostate cancer.,2024,10.1016/j.neo.2024.101023,https://pubmed.ncbi.nlm.nih.gov/38944914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,40823742,Alterations of NMDAR Subunits in the Cerebrospinal Fluid Across Neurodegenerative and Immunological Disorders.,2025,10.1111/jnc.70192,https://pubmed.ncbi.nlm.nih.gov/40823742/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,40527340,Influence of Glutamate Neurotransmission Genes on the Outcomes of Antipsychotic Treatments.,2025,10.1055/a-2603-0871,https://pubmed.ncbi.nlm.nih.gov/40527340/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,40943499,Neurotransmitter Genes in the Nucleus Accumbens That Are Involved in the Development of a Behavioral Pathology After Positive Fighting Experiences and Their Deprivation: A Conceptual Paradigm for Data Analysis.,2025,10.3390/ijms26178580,https://pubmed.ncbi.nlm.nih.gov/40943499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,38028990,Roux-en-Y Gastric Bypass Improves Insulin Sensitivity in Obese Rats with Type 2 Diabetes Mellitus by Regulating the Grin3a/AMPK Signal Axis in Hypothalamic Arcuate Nucleus.,2023,10.2147/dmso.s430445,https://pubmed.ncbi.nlm.nih.gov/38028990/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,39756548,Incidence of alternative splicing associated with sex and opioid effects in the axon guidance pathway.,2025,10.1016/j.gene.2025.149215,https://pubmed.ncbi.nlm.nih.gov/39756548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,41904502,A lactylation-associated gene signature predicts prognosis in neuroblastoma and identifies RPS6KA6 as a candidate biomarker.,2026,10.1186/s12885-026-15911-9,https://pubmed.ncbi.nlm.nih.gov/41904502/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,39449864,Erratum: Roux-En-Y Gastric Bypass Improves Insulin Sensitivity in Obese Rats with Type 2 Diabetes Mellitus by Regulating the Grin3a/AMPK Signal Axis in Hypothalamic Arcuate Nucleus [Corrigendum].,2024,10.2147/dmso.s501050,https://pubmed.ncbi.nlm.nih.gov/39449864/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,41002374,Trisomy 21 Disrupts Thyroid Hormones Signaling During Human iPSC-Derived Neural Differentiation In Vitro.,2025,10.3390/cells14181407,https://pubmed.ncbi.nlm.nih.gov/41002374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,37485581,Strain hypothesis and additional evidence of the GluN3A deficiency-mediated pathogenesis of Alzheimer's disease.,2023,10.1002/alz.13374,https://pubmed.ncbi.nlm.nih.gov/37485581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,37404751,Bioinformatic-based genetic characterizations of neural regulation in skin cutaneous melanoma.,2023,10.3389/fonc.2023.1166373,https://pubmed.ncbi.nlm.nih.gov/37404751/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,34406079,A GRIN3A polymorphism may be associated with glucocorticoid-induced symptomatic osteonecrosis in children with acute lymphoblastic leukemia.,2021,10.2217/pme-2020-0167,https://pubmed.ncbi.nlm.nih.gov/34406079/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,35144563,Micronutrient supplementation affects DNA methylation in male gonads with potential intergenerational epigenetic inheritance involving the embryonic development through glutamate receptor-associated genes.,2022,10.1186/s12864-022-08348-4,https://pubmed.ncbi.nlm.nih.gov/35144563/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,35899178,The Association of lncRNA and mRNA Changes in Adipose Tissue with Improved Insulin Resistance in Type 2 Obese Diabetes Mellitus Rats after Roux-en-Y Gastric Bypass.,2022,10.1155/2022/8902916,https://pubmed.ncbi.nlm.nih.gov/35899178/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,38075685,A pharmacogenetic study of perampanel: association between rare variants of glutamate receptor genes and outcomes.,2023,10.3389/fgene.2023.1215493,https://pubmed.ncbi.nlm.nih.gov/38075685/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,34912722,Identification of the Nerve-Cancer Cross-Talk-Related Prognostic Gene Model in Head and Neck Squamous Cell Carcinoma.,2021,10.3389/fonc.2021.788671,https://pubmed.ncbi.nlm.nih.gov/34912722/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,30059533,"Impacts of GRIN3A, GRM6 and TPH2 genetic polymorphisms on quality of life in methadone maintenance therapy population.",2018,10.1371/journal.pone.0201408,https://pubmed.ncbi.nlm.nih.gov/30059533/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,35903056,"Differential Gene Expression in the Hippocampi of Nonhuman Primates Chronically Exposed to Methamphetamine, Cocaine, or Heroin.",2022,10.30773/pi.2022.0004,https://pubmed.ncbi.nlm.nih.gov/35903056/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,24278430,Association between GRIN3A gene polymorphism in Kawasaki disease and coronary artery aneurysms in Taiwanese children.,2013,10.1371/journal.pone.0081384,https://pubmed.ncbi.nlm.nih.gov/24278430/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,35007623,The effects of predator odor (TMT) exposure and mGlu3 NAM pretreatment on behavioral and NMDA receptor adaptations in the brain.,2022,10.1016/j.neuropharm.2022.108943,https://pubmed.ncbi.nlm.nih.gov/35007623/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,22914463,Association of polymorphisms in neuroprotection and oxidative stress genes and neurodevelopmental outcomes after preterm birth.,2012,10.1097/aog.0b013e318265f232,https://pubmed.ncbi.nlm.nih.gov/22914463/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRIN3A,ENSG00000198785,Unsafe,25450229,The contribution of rare and common variants in 30 genes to risk nicotine dependence.,2015,10.1038/mp.2014.156,https://pubmed.ncbi.nlm.nih.gov/25450229/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,42596829,G protein‑coupled receptor kinase 4 governs early kidney development via STAT3 and Nhe3a.,2026,10.3892/ijmm.2026.5953,https://pubmed.ncbi.nlm.nih.gov/42596829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,41915656,Salidroside protects against high-altitude hypoxia-induced kidney injury via regulation of renal dopamine D1-like receptors.,2026,10.1371/journal.pone.0344999,https://pubmed.ncbi.nlm.nih.gov/41915656/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,41407053,GRK4 R65L causes salt-sensitive hypertension by augmenting renal Hao2-mediated oxidative stress via increasing the phosphorylation of TPI1 and promoting H3K27ac expression.,2026,10.1016/j.freeradbiomed.2025.12.017,https://pubmed.ncbi.nlm.nih.gov/41407053/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,41351606,PM2.5-induced hypertension via renal GRK4/Nedd4L/ENaC axis: epigenetic and post-translational mechanisms.,2025,10.1080/08037051.2025.2600133,https://pubmed.ncbi.nlm.nih.gov/41351606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,40055267,The Role of G-Protein-Coupled Receptor Kinase 4 in Modulating Mitophagy and Oxidative Stress in Cerebral Ischemia-Reperfusion Injury.,2025,10.1007/s12017-025-08843-3,https://pubmed.ncbi.nlm.nih.gov/40055267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,39558015,A cross-tissue transcriptome-wide association study reveals GRK4 as a novel susceptibility gene for COPD.,2024,10.1038/s41598-024-80122-w,https://pubmed.ncbi.nlm.nih.gov/39558015/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,40763158,Role of G-protein-coupled receptor kinase 4 on the dysfunction of renal Mas receptor in hypertension.,2025,10.1371/journal.pone.0329547,https://pubmed.ncbi.nlm.nih.gov/40763158/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,41161545,Omentin-1 attenuates salt-sensitive hypertension via GRK4/AT&lt;sub&gt;1&lt;/sub&gt;R downregulation mediated by the ROS/c-Myc pathway.,2026,10.1016/j.bcp.2025.117489,https://pubmed.ncbi.nlm.nih.gov/41161545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,40484036,Inhibition of GRK4 reduces arrhythmia susceptibility and alleviates connexin43 dysregulation after myocardial infarction.,2025,10.1016/j.bcp.2025.117035,https://pubmed.ncbi.nlm.nih.gov/40484036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,38638965,Quantitative proteomics assay reveals G protein-coupled receptor kinase 4-induced HepG2 cell growth inhibition.,2024,10.1016/j.heliyon.2024.e29514,https://pubmed.ncbi.nlm.nih.gov/38638965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,39743506,Genetic variants of accessory proteins and G proteins in human genetic disease.,2025,10.1080/10408363.2024.2431853,https://pubmed.ncbi.nlm.nih.gov/39743506/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,37994311,"GRK4, A Potential Link between Hypertension and Breast Cancer.",2022,,https://pubmed.ncbi.nlm.nih.gov/37994311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,34103922,The Hypertension Related Gene G-Protein Coupled Receptor Kinase 4 Contributes to Breast Cancer Proliferation.,2021,10.1177/11782234211015753,https://pubmed.ncbi.nlm.nih.gov/34103922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,38951961,"Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6, ADRB1, ADRB2, ADRA2C, GRK4, and GRK5 Genotypes and Beta-Blocker Therapy.",2024,10.1002/cpt.3351,https://pubmed.ncbi.nlm.nih.gov/38951961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,40285373,The Beta-Blocker Pharmacogenetic Puzzle: More Pieces of Evidence for Pharmacodynamic Candidate Variants.,2025,10.1111/cts.70239,https://pubmed.ncbi.nlm.nih.gov/40285373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,36810260,Kinase Activity Is Not Required for G Protein-Coupled Receptor Kinase 4 Restraining mTOR Signaling during Cilia and Kidney Development.,2023,10.1681/asn.0000000000000082,https://pubmed.ncbi.nlm.nih.gov/36810260/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,35487286,Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics.,2022,10.1016/j.pharmthera.2022.108194,https://pubmed.ncbi.nlm.nih.gov/35487286/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,37641972,Effect of GRK4 on renal gastrin receptor regulation in hypertension.,2023,10.1080/10641963.2023.2245580,https://pubmed.ncbi.nlm.nih.gov/37641972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,35769816,G Protein-Coupled Receptor Kinase 4 Is a Novel Prognostic Factor in Hepatocellular Carcinoma.,2022,10.1155/2022/2628879,https://pubmed.ncbi.nlm.nih.gov/35769816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,36669643,Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury.,2023,10.1016/j.kint.2022.12.023,https://pubmed.ncbi.nlm.nih.gov/36669643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,38706793,Dissecting the shared genetic architecture between Alzheimer's disease and frailty: a cross-trait meta-analyses of genome-wide association studies.,2024,10.3389/fgene.2024.1376050,https://pubmed.ncbi.nlm.nih.gov/38706793/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,37562012,Implications of In Vitro Multi-Serine Phosphorylation of Alpha-Synuclein in Aggregation and Cytotoxicity.,2023,10.1021/acschemneuro.3c00234,https://pubmed.ncbi.nlm.nih.gov/37562012/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,30115642,Computational modeling and confirmation of leukemia-associated minor histocompatibility antigens.,2018,10.1182/bloodadvances.2018022475,https://pubmed.ncbi.nlm.nih.gov/30115642/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,31555351,Elimination of HER3-expressing breast cancer cells using aptamer-siRNA chimeras.,2019,10.3892/etm.2019.7753,https://pubmed.ncbi.nlm.nih.gov/31555351/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,34621245,Identification of mRNA Prognostic Markers for TGCT by Integration of Co-Expression and CeRNA Network.,2021,10.3389/fendo.2021.743155,https://pubmed.ncbi.nlm.nih.gov/34621245/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,38633331,Pharmacogenomics of Hypertension in Africa: Paving the Way for a Pharmacogenetic-Based Approach for the Treatment of Hypertension in Africans.,2023,10.1155/2023/9919677,https://pubmed.ncbi.nlm.nih.gov/38633331/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,34164528,A narrative review on the interaction between genes and the treatment of hypertension and breast cancer.,2021,10.21037/atm-21-2133,https://pubmed.ncbi.nlm.nih.gov/34164528/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,36878964,"Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs.",2023,10.1038/s41380-023-01998-0,https://pubmed.ncbi.nlm.nih.gov/36878964/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,32573992,Normal Ethanol Sensitivity and Rapid Tolerance Require the G Protein Receptor Kinase 2 in Ellipsoid Body Neurons in Drosophila.,2020,10.1111/acer.14396,https://pubmed.ncbi.nlm.nih.gov/32573992/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,27792639,Downregulation of Renal G Protein-Coupled Receptor Kinase Type 4 Expression via Ultrasound-Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats.,2016,10.1161/jaha.116.004028,https://pubmed.ncbi.nlm.nih.gov/27792639/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,28969913,Genetic predisposition to bevacizumab-induced hypertension.,2017,10.1016/j.ygyno.2017.09.017,https://pubmed.ncbi.nlm.nih.gov/28969913/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,22949529,G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension.,2012,10.1161/hypertensionaha.112.198721,https://pubmed.ncbi.nlm.nih.gov/22949529/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,32391018,ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins.,2020,10.3389/fimmu.2020.00720,https://pubmed.ncbi.nlm.nih.gov/32391018/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,22278145,A comparison of the natriuretic and kaliuretic effects of cicletanine and hydrochlorothiazide in prehypertensive and hypertensive humans.,2012,10.1097/hjh.0b013e32835022a8,https://pubmed.ncbi.nlm.nih.gov/22278145/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,19119263,G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions.,2009,10.1038/ajh.2008.341,https://pubmed.ncbi.nlm.nih.gov/19119263/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,22987918,Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter.,2012,10.1161/hypertensionaha.112.196071,https://pubmed.ncbi.nlm.nih.gov/22987918/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,16636192,Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression.,2006,10.1161/01.hyp.0000222004.74872.17,https://pubmed.ncbi.nlm.nih.gov/16636192/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRK4,ENSG00000125388,Unsafe,8626439,Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants.,1996,10.1074/jbc.271.11.6403,https://pubmed.ncbi.nlm.nih.gov/8626439/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,42722693,Structural basis of active state coupling of metabotropic glutamate receptor 8 to beta-arrestins.,2026,10.1038/s41467-026-77556-3,https://pubmed.ncbi.nlm.nih.gov/42722693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,42134565,"Metabotropic glutamate receptors in the testis: An integrative bioinformatic review of neuroendocrine, reproductive, and Neuropsychopharmacological aspects.",2026,10.1016/j.pnpbp.2026.111744,https://pubmed.ncbi.nlm.nih.gov/42134565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,41667769,Neuronal antibody targeting metabotropic glutamate receptor 8 in five cases and its pathogenicity.,2026,10.1007/s00415-026-13657-9,https://pubmed.ncbi.nlm.nih.gov/41667769/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,41554730,Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder.,2026,10.1038/s41467-026-68351-1,https://pubmed.ncbi.nlm.nih.gov/41554730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,40747360,Screening and Verification COPD-OSA Overlap Syndrome Core Genes Using Bioinformatics.,2025,10.2147/copd.s528703,https://pubmed.ncbi.nlm.nih.gov/40747360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,42722688,Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins.,2026,10.1038/s41467-026-77555-4,https://pubmed.ncbi.nlm.nih.gov/42722688/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,42364358,Inflammation-associated alterations in mGluR transcript expression in the human nucleus accumbens independent of schizophrenia diagnosis.,2026,10.1016/j.schres.2026.06.020,https://pubmed.ncbi.nlm.nih.gov/42364358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,39396906,Hippocampal tau-induced GRIN3A deficiency in Alzheimer's disease.,2024,10.1002/2211-5463.13904,https://pubmed.ncbi.nlm.nih.gov/39396906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,41011178,Isoliquiritigenin as a Neuronal Radiation Mitigant: Mitigating Radiation-Induced Anhedonia Tendency Targeting Grik3/Grm8/Grin3a via Integrated Proteomics and AI-Driven Discovery.,2025,10.3390/ph18091307,https://pubmed.ncbi.nlm.nih.gov/41011178/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,40800604,Computational identification of key genetic drivers in COPD: A first step towards uncovering candidate biomarkers in smokers.,2025,10.1016/j.bbrep.2025.102193,https://pubmed.ncbi.nlm.nih.gov/40800604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,42239799,Spatiotemporal patterns of gene expression changes in the mouse dentate gyrus following entorhinal denervation.,2026,10.3389/fnmol.2026.1758390,https://pubmed.ncbi.nlm.nih.gov/42239799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,38644811,Rare CRHR2 and GRM8 variants identified as candidate factors associated with eating disorders in Japanese patients by whole exome sequencing.,2024,10.1016/j.heliyon.2024.e28643,https://pubmed.ncbi.nlm.nih.gov/38644811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,40133378,Developmental differentiation of mouse inner ear neuron subpopulations resolved with a peripherin-promoter reporter within the Grm8 locus.,2025,10.1038/s41598-025-94011-3,https://pubmed.ncbi.nlm.nih.gov/40133378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,38918065,Thalamocortical mGlu8 Modulates Dorsal Thalamus Excitatory Transmission and Sensorimotor Activity.,2024,10.1523/jneurosci.0119-24.2024,https://pubmed.ncbi.nlm.nih.gov/38918065/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,42650067,"Multi-Omic Analysis of Cerebrospinal Fluid Metabolites in Autism Spectrum Disorder: Biomarker Identification, Metabolic Genetics Insights, and Network Toxicology.",2026,10.3390/genes17080874,https://pubmed.ncbi.nlm.nih.gov/42650067/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,39384625,Psychotic symptoms associated increased CpG methylation of metabotropic glutamate receptor 8 gene in Chinese Han males with schizophrenia and methamphetamine induced psychotic disorder: a longitudinal study.,2024,10.1038/s41537-024-00506-9,https://pubmed.ncbi.nlm.nih.gov/39384625/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,40527340,Influence of Glutamate Neurotransmission Genes on the Outcomes of Antipsychotic Treatments.,2025,10.1055/a-2603-0871,https://pubmed.ncbi.nlm.nih.gov/40527340/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,40010564,Red nucleus mGluR4 and mGluR8 inhibit nociception and the development of neuropathic pain by restraining the expressions of TNF-α and IL-1β.,2025,10.1016/j.neuropharm.2025.110387,https://pubmed.ncbi.nlm.nih.gov/40010564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,41942605,Extensive genetic interactions (epistasis) linked to alcohol use disorder in a high-risk population.,2026,10.1038/s42003-026-09971-7,https://pubmed.ncbi.nlm.nih.gov/41942605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,38414734,Elucidating shared biomarkers in gastroesophageal reflux disease and idiopathic pulmonary fibrosis: insights into novel therapeutic targets and the role of angelicae sinensis radix.,2024,10.3389/fphar.2024.1348708,https://pubmed.ncbi.nlm.nih.gov/38414734/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,38694033,Exploration of prognostic and treatment markers in hepatocellular carcinoma via GPCR-related genes analysis.,2024,10.1016/j.heliyon.2024.e29659,https://pubmed.ncbi.nlm.nih.gov/38694033/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,39298028,"Group III metabotropic glutamate receptors: guardians against excitotoxicity in ischemic brain injury, with implications for neonatal contexts.",2024,10.1007/s43440-024-00651-z,https://pubmed.ncbi.nlm.nih.gov/39298028/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,33661276,Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation.,2021,10.1084/jem.20201290,https://pubmed.ncbi.nlm.nih.gov/33661276/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,32299001,GRM8 genotype is associated with externalizing disorders and greater inter-trial variability in brain activation during a response inhibition task.,2020,10.1016/j.clinph.2020.02.031,https://pubmed.ncbi.nlm.nih.gov/32299001/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,36213225,Expression of group II and III mGluRs in the carotid body and its role in the carotid chemoreceptor response to acute hypoxia.,2022,10.3389/fphys.2022.1008073,https://pubmed.ncbi.nlm.nih.gov/36213225/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,35772967,Meclizine and Metabotropic Glutamate Receptor Agonists Attenuate Severe Pain and Ca2+ Activity of Primary Sensory Neurons in Chemotherapy-Induced Peripheral Neuropathy.,2022,10.1523/jneurosci.1064-21.2022,https://pubmed.ncbi.nlm.nih.gov/35772967/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,35368665,A Novel Prognostic Model for Identifying the Risk of Hepatocellular Carcinoma Based on Angiogenesis Factors.,2022,10.3389/fgene.2022.857215,https://pubmed.ncbi.nlm.nih.gov/35368665/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,31210112,The Modulation of Pain by Metabotropic Glutamate Receptors 7 and 8 in the Dorsal Striatum.,2020,10.2174/1570159x17666190618121859,https://pubmed.ncbi.nlm.nih.gov/31210112/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,30970677,Metabotropic Glutamate Receptor 5 and 8 Modulate the Ameliorative Effect of Ultramicronized Palmitoylethanolamide on Cognitive Decline Associated with Neuropathic Pain.,2019,10.3390/ijms20071757,https://pubmed.ncbi.nlm.nih.gov/30970677/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,33816256,Novel Molecular Hallmarks of Group 3 Medulloblastoma by Single-Cell Transcriptomics.,2021,10.3389/fonc.2021.622430,https://pubmed.ncbi.nlm.nih.gov/33816256/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,34233526,Deep learning prediction of attention-deficit hyperactivity disorder in African Americans by copy number variation.,2021,10.1177/15353702211018970,https://pubmed.ncbi.nlm.nih.gov/34233526/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,25918841,A genome wide association study links glutamate receptor pathway to sporadic Creutzfeldt-Jakob disease risk.,2014,10.1371/journal.pone.0123654,https://pubmed.ncbi.nlm.nih.gov/25918841/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,36923478,Changes in DNA methylation profile in liver tissue during progression of HCV-induced fibrosis to hepatocellular carcinoma.,2023,10.18699/vjgb-23-10,https://pubmed.ncbi.nlm.nih.gov/36923478/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,36211978,Attention-deficit/hyperactive disorder updates.,2022,10.3389/fnmol.2022.925049,https://pubmed.ncbi.nlm.nih.gov/36211978/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRM8,ENSG00000179603,Unsafe,20080129,Sex-dependent cognitive phenotype of mice lacking mGluR8.,2010,10.1016/j.bbr.2010.01.006,https://pubmed.ncbi.nlm.nih.gov/20080129/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,41917816,Expression and regulation of lncRNAs in the testes of Yili geese with high and low sperm motility.,2026,10.1186/s12864-026-12731-w,https://pubmed.ncbi.nlm.nih.gov/41917816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,42255817,Schinzel-Giedion Syndrome in One of Dizygotic Twins: Confirmation of a De Novo SET Binding Protein 1 (SETBP1) Variant and Classic Multisystem Phenotype.,2026,10.7759/cureus.108270,https://pubmed.ncbi.nlm.nih.gov/42255817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,41430327,Genes linked to hearing and vestibular phenotypes in humans and mice: an interspecies systematic review.,2025,10.1186/s40246-025-00891-x,https://pubmed.ncbi.nlm.nih.gov/41430327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,39858137,Uncovering Molecular Mechanisms of Feed Efficiency in Pigs Through Multi-Omics Analysis of the Jejunum.,2025,10.3390/ani15020137,https://pubmed.ncbi.nlm.nih.gov/39858137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,35235570,Grxcr1 regulates hair bundle morphogenesis and is required for normal mechanoelectrical transduction in mouse cochlear hair cells.,2022,10.1371/journal.pone.0261530,https://pubmed.ncbi.nlm.nih.gov/35235570/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,34366792,Murine GRXCR1 Has a Different Function Than GRXCR2 in the Morphogenesis of Stereocilia.,2021,10.3389/fncel.2021.714070,https://pubmed.ncbi.nlm.nih.gov/34366792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,36980911,Genome-Wide Analysis of lncRNA and mRNA Expression in the Uterus of Laying Hens during Aging.,2023,10.3390/genes14030639,https://pubmed.ncbi.nlm.nih.gov/36980911/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,30380418,Grxcr1 Promotes Hair Bundle Development by Destabilizing the Physical Interaction between Harmonin and Sans Usher Syndrome Proteins.,2018,10.1016/j.celrep.2018.10.005,https://pubmed.ncbi.nlm.nih.gov/30380418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,33693626,Common and Rare Genetic Variants That Could Contribute to Severe Otitis Media in an Australian Aboriginal Population.,2021,10.1093/cid/ciab216,https://pubmed.ncbi.nlm.nih.gov/33693626/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,34472303,[Analysis of apple postharment damage under high CO₂ concentration by transcriptome combined with metabolome].,2021,10.13345/j.cjb.200547,https://pubmed.ncbi.nlm.nih.gov/34472303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,32641180,Genome-wide screen to identify genetic loci associated with cognitive decline in late-life depression.,2024,10.1017/s1041610220001143,https://pubmed.ncbi.nlm.nih.gov/32641180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,20137778,Homozygosity mapping reveals mutations of GRXCR1 as a cause of autosomal-recessive nonsyndromic hearing impairment.,2010,10.1016/j.ajhg.2009.12.017,https://pubmed.ncbi.nlm.nih.gov/20137778/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,35237186,Genome-Wide Association Study on Three Behaviors Tested in an Open Field in Heterogeneous Stock Rats Identifies Multiple Loci Implicated in Psychiatric Disorders.,2022,10.3389/fpsyt.2022.790566,https://pubmed.ncbi.nlm.nih.gov/35237186/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,35848598,Identification of key candidate genes for wing length-related traits by whole-genome resequencing in 772 geese.,2022,10.1080/00071668.2022.2102889,https://pubmed.ncbi.nlm.nih.gov/35848598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,32211215,Characterization of the transcriptomes of Atoh1-induced hair cells in the mouse cochlea.,2020,,https://pubmed.ncbi.nlm.nih.gov/32211215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,20137774,Mutations in Grxcr1 are the basis for inner ear dysfunction in the pirouette mouse.,2010,10.1016/j.ajhg.2010.01.016,https://pubmed.ncbi.nlm.nih.gov/20137774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,30157177,Grxcr2 is required for stereocilia morphogenesis in the cochlea.,2018,10.1371/journal.pone.0201713,https://pubmed.ncbi.nlm.nih.gov/30157177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,34523824,Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease.,2021,10.1002/jcsm.12782,https://pubmed.ncbi.nlm.nih.gov/34523824/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,17918732,An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss.,2008,10.1002/humu.20617,https://pubmed.ncbi.nlm.nih.gov/17918732/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,21185188,THRUMIN1 is a light-regulated actin-bundling protein involved in chloroplast motility.,2011,10.1016/j.cub.2010.11.059,https://pubmed.ncbi.nlm.nih.gov/21185188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GRXCR1,ENSG00000215203,Unsafe,31389194,Sequence variants in genes causing nonsyndromic hearing loss in a Pakistani cohort.,2019,10.1002/mgg3.917,https://pubmed.ncbi.nlm.nih.gov/31389194/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSG1,ENSG00000111305,Unsafe,42754520,Population-specific rare variants influence age at diagnosis in Korean inflammatory bowel disease.,2026,10.3904/kjim.2026.055,https://pubmed.ncbi.nlm.nih.gov/42754520/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSG1,ENSG00000111305,Unsafe,37673338,Differential regulation of tetramerization of the AMPA receptor glutamate-gated ion channel by auxiliary subunits.,2023,10.1016/j.jbc.2023.105227,https://pubmed.ncbi.nlm.nih.gov/37673338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSG1,ENSG00000111305,Unsafe,35663320,The Role of Testosterone in Spermatogenesis: Lessons From Proteome Profiling of Human Spermatozoa in Testosterone Deficiency.,2022,10.3389/fendo.2022.852661,https://pubmed.ncbi.nlm.nih.gov/35663320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSG1,ENSG00000111305,Unsafe,35070935,Estrogen exposure causes the progressive growth of SK-Hep1-derived tumor in ovariectomized mice.,2022,10.1007/s43188-021-00100-6,https://pubmed.ncbi.nlm.nih.gov/35070935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSG1,ENSG00000111305,Unsafe,30269365,Identification and functional analysis of spermatogenesis-associated gene modules in azoospermia by weighted gene coexpression network analysis.,2019,10.1002/jcb.27677,https://pubmed.ncbi.nlm.nih.gov/30269365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSG1,ENSG00000111305,Unsafe,36672520,A Novel Frameshift &lt;i&gt;CHD4&lt;/i&gt; Variant Leading to Sifrim-Hitz-Weiss Syndrome in a Proband with a Subclinical Familial t(17;19) and a Large dup(2)(q14.3q21.1).,2022,10.3390/biomedicines11010012,https://pubmed.ncbi.nlm.nih.gov/36672520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSG1,ENSG00000111305,Unsafe,28199486,"Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar Interneurons in the Mouse Retina.",2017,10.1167/iovs.16-19767,https://pubmed.ncbi.nlm.nih.gov/28199486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSG1,ENSG00000111305,Unsafe,18325338,Germ cell-specific gene 1 targets testis-specific poly(A) polymerase to the endoplasmic reticulum through protein-protein interactions.,2008,10.1016/j.febslet.2008.01.065,https://pubmed.ncbi.nlm.nih.gov/18325338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSG1,ENSG00000111305,Unsafe,24012201,Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis.,2013,10.1016/j.fertnstert.2013.07.1999,https://pubmed.ncbi.nlm.nih.gov/24012201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSG1,ENSG00000111305,Unsafe,9504908,Yeast meiotic mutants proficient for the induction of ectopic recombination.,1998,10.1093/genetics/148.2.581,https://pubmed.ncbi.nlm.nih.gov/9504908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSG1,ENSG00000111305,Unsafe,18421856,[Change of chart genes expression in small intestines of mouse induced by electromagnetic pulse irradiation].,2008,,https://pubmed.ncbi.nlm.nih.gov/18421856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSG1,ENSG00000111305,Unsafe,16079147,"Trs85 (Gsg1), a component of the TRAPP complexes, is required for the organization of the preautophagosomal structure during selective autophagy via the Cvt pathway.",2005,10.1074/jbc.m501701200,https://pubmed.ncbi.nlm.nih.gov/16079147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,42537487,Betaine protects bovine granulosa cells from oxidative stress involving STAT3-associated regulation of GSTA5.,2026,10.1016/j.theriogenology.2026.118107,https://pubmed.ncbi.nlm.nih.gov/42537487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,42641857,Polypropylene microplastics orchestrate oxidative stress microenvironment and trigger metabolic reprogramming in mouse kidney as revealed by Raman spectra and metabolomics.,2026,10.1016/j.envpol.2026.129000,https://pubmed.ncbi.nlm.nih.gov/42641857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,40375987,Integrative single-cell RNA sequencing and bulk RNA sequencing reveals the characteristics of glutathione metabolism and protective role of GSTA4 gene in pancreatic cancer.,2025,10.3389/fimmu.2025.1571431,https://pubmed.ncbi.nlm.nih.gov/40375987/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,38832034,Nrf2 pathway activation promotes the expression of genes related to glutathione metabolism in alcohol-exposed astrocytes.,2024,10.7717/peerj.17541,https://pubmed.ncbi.nlm.nih.gov/38832034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,40762741,Exploring the causal relationship between hemoglobin and pancreatic cancer and its potential mechanisms through bioinformatics and Mendelian randomization.,2025,10.1007/s12672-025-03352-y,https://pubmed.ncbi.nlm.nih.gov/40762741/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,40381828,Transcriptomic profiling provide insights into swainsonine-induced toxic responses and activation of the aryl hydrocarbon receptor pathway.,2025,10.1016/j.fct.2025.115556,https://pubmed.ncbi.nlm.nih.gov/40381828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,37372010,Polygenic Variants Linked to Oxidative Stress and the Antioxidant System Are Associated with Type 2 Diabetes Risk and Interact with Lifestyle Factors.,2023,10.3390/antiox12061280,https://pubmed.ncbi.nlm.nih.gov/37372010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,39181079,Gut dysbiosis of Rana zhenhaiensis tadpoles after lead (Pb) exposure based on integrated analysis of microbiota and gut transcriptome.,2024,10.1016/j.ecoenv.2024.116922,https://pubmed.ncbi.nlm.nih.gov/39181079/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,39036455,"Deciphering Molecular Mechanisms of Cutaneous Leishmaniasis, Pathogenesis and Drug Repurposing through Systems Biology",2024,10.61186/ibj.4177,https://pubmed.ncbi.nlm.nih.gov/39036455/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,40369321,Robust hierarchical co-clustering for exploring toxicogenomic biomarkers and their chemical regulators.,2025,10.1038/s41598-025-99568-7,https://pubmed.ncbi.nlm.nih.gov/40369321/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,36098941,Oral Exposure to Lead Acetate for 28 Days Reduces the Number of Neural Progenitor Cells but Increases the Number and Synaptic Plasticity of Newborn Granule Cells in Adult Hippocampal Neurogenesis of Young-Adult Rats.,2022,10.1007/s12640-022-00577-5,https://pubmed.ncbi.nlm.nih.gov/36098941/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,33658803,Renal Transcriptomics Reveals the Carcinogenic Mechanism of Ethyl Carbamate in Musalais.,2021,10.2147/ott.s282125,https://pubmed.ncbi.nlm.nih.gov/33658803/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,33909675,Characterization of glutathione S-transferase enzymes in Dictyostelium discoideum suggests a functional role for the GSTA2 isozyme in cell proliferation and development.,2021,10.1371/journal.pone.0250704,https://pubmed.ncbi.nlm.nih.gov/33909675/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,32949369,"Transcriptomic analysis of the effect of (E)-3-(3,5-dimethoxyphenyl)-1-(2-methoxyphenyl) prop-2-en-1-one (DPP23) on reactive oxygen species generation in MIA PaCa-2 pancreatic cancer cells.",2020,10.1007/s13258-020-00994-w,https://pubmed.ncbi.nlm.nih.gov/32949369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,26995790,"Treatment of experimental human breast cancer and lung cancer brain metastases in mice by macitentan, a dual antagonist of endothelin receptors, combined with paclitaxel.",2016,10.1093/neuonc/now037,https://pubmed.ncbi.nlm.nih.gov/26995790/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,32586242,A Knock-Down Cell-Based Study for the Functional Analysis of Chloride Intracellular Channel 1 (CLIC1): Integrated Proteomics and Microarray Study.,2021,10.2174/0929866527666200625204650,https://pubmed.ncbi.nlm.nih.gov/32586242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,30262974,Toxic Dose prediction of Chemical Compounds to Biomarkers using an ANOVA based Gene Expression Analysis.,2018,10.6026/97320630014369,https://pubmed.ncbi.nlm.nih.gov/30262974/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,23827461,Systematic identification and characterization of glutathione S-transferases in cynomolgus macaque.,2013,10.1016/j.bcp.2013.06.022,https://pubmed.ncbi.nlm.nih.gov/23827461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,31398888,Assessment of Drugs Toxicity and Associated Biomarker Genes Using Hierarchical Clustering.,2019,10.3390/medicina55080451,https://pubmed.ncbi.nlm.nih.gov/31398888/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,33203707,Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations.,2021,10.2337/dc20-1328,https://pubmed.ncbi.nlm.nih.gov/33203707/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,24388910,Impact of long term Fe³⁺ toxicity on expression of glutathione system in rat liver.,2014,10.1016/j.etap.2013.12.007,https://pubmed.ncbi.nlm.nih.gov/24388910/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,10085232,"Determinants of specificity for aflatoxin B1-8,9-epoxide in alpha-class glutathione S-transferases.",1999,10.1042/bj3390095,https://pubmed.ncbi.nlm.nih.gov/10085232/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,20200426,Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.,2010,10.1158/1055-9965.epi-09-0871,https://pubmed.ncbi.nlm.nih.gov/20200426/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,22545673,Testing an aflatoxin B1 gene signature in rat archival tissues.,2012,10.1021/tx3000945,https://pubmed.ncbi.nlm.nih.gov/22545673/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,21390191,Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy.,2011,10.1593/neo.11112,https://pubmed.ncbi.nlm.nih.gov/21390191/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,9620880,Growth hormone- and testosterone-dependent regulation of glutathione transferase subunit A5 in rat liver.,1998,10.1042/bj3320763,https://pubmed.ncbi.nlm.nih.gov/9620880/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTA5,ENSG00000182793,Unsafe,19800383,Glutathione S-transferase expression and isoenzyme composition during cell differentiation of Caco-2 cells.,2009,10.1016/j.tox.2009.09.017,https://pubmed.ncbi.nlm.nih.gov/19800383/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,42298232,Haploid Parthenotes Have Higher Demand for Glucose and Pyruvate Compared to Normally Fertilized Embryos During their In Vitro Development.,2026,10.1007/s43032-026-02130-7,https://pubmed.ncbi.nlm.nih.gov/42298232/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,37609638,Remote regulation of rs80245547 and rs72673891 mediated by transcription factors C-Jun and CREB1 affect GSTCD expression.,2023,10.1016/j.isci.2023.107383,https://pubmed.ncbi.nlm.nih.gov/37609638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,41687531,EcoToxChip reveals immune and metabolic pathway disruption in fish chronically exposed to stormwater-impacted environments.,2026,10.1016/j.aquatox.2026.107748,https://pubmed.ncbi.nlm.nih.gov/41687531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,39418301,Partial correlation network analysis identifies coordinated gene expression within a regional cluster of COPD genome-wide association signals.,2024,10.1371/journal.pcbi.1011079,https://pubmed.ncbi.nlm.nih.gov/39418301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,39595264,Genome-Wide Selection Signals Reveal Candidate Genes Associated with Plateau Adaptation in Tibetan Sheep.,2024,10.3390/ani14223212,https://pubmed.ncbi.nlm.nih.gov/39595264/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,31370853,Defining a role for lung function associated gene GSTCD in cell homeostasis.,2019,10.1186/s12931-019-1146-3,https://pubmed.ncbi.nlm.nih.gov/31370853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,31513609,Exposure to lipopolysaccharide (LPS) reduces contractile response of small airways from GSTCD-/- mice.,2019,10.1371/journal.pone.0221899,https://pubmed.ncbi.nlm.nih.gov/31513609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,33574492,Investigation of Proteus vulgaris and Elizabethkingia meningoseptica invasion on muscle oxidative stress and autophagy in Chinese soft-shelled turtle (Pelodiscus sinensis).,2021,10.1038/s41598-021-83388-6,https://pubmed.ncbi.nlm.nih.gov/33574492/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,24058608,GSTCD and INTS12 regulation and expression in the human lung.,2013,10.1371/journal.pone.0074630,https://pubmed.ncbi.nlm.nih.gov/24058608/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,34941886,"Hepatic transcriptome analysis identifies genes, polymorphisms and pathways involved in the fatty acids metabolism in sheep.",2021,10.1371/journal.pone.0260514,https://pubmed.ncbi.nlm.nih.gov/34941886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,36263427,Genome-wide analysis identified candidate variants and genes associated with heat stress adaptation in Egyptian sheep breeds.,2022,10.3389/fgene.2022.898522,https://pubmed.ncbi.nlm.nih.gov/36263427/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,34556755,"Clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus among children in Qatar.",2021,10.1038/s41598-021-98460-4,https://pubmed.ncbi.nlm.nih.gov/34556755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,28335732,Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways.,2017,10.1186/s12864-017-3628-3,https://pubmed.ncbi.nlm.nih.gov/28335732/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,30658572,A global analysis of CNVs in diverse yak populations using whole-genome resequencing.,2019,10.1186/s12864-019-5451-5,https://pubmed.ncbi.nlm.nih.gov/30658572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,24929828,Genome-wide association analysis identifies six new loci associated with forced vital capacity.,2014,10.1038/ng.3011,https://pubmed.ncbi.nlm.nih.gov/24929828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,24915237,"Interaction effects of long-term air pollution exposure and variants in the GSTP1, GSTT1 and GSTCD genes on risk of acute myocardial infarction and hypertension: a case-control study.",2014,10.1371/journal.pone.0099043,https://pubmed.ncbi.nlm.nih.gov/24915237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,20010834,Genome-wide association study identifies five loci associated with lung function.,2010,10.1038/ng.501,https://pubmed.ncbi.nlm.nih.gov/20010834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,23541324,Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients.,2013,10.1016/j.jaci.2013.01.051,https://pubmed.ncbi.nlm.nih.gov/23541324/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,27236378,Genome-wide association study for sperm membrane integrity in frozen-thawed semen of Holstein-Friesian bulls.,2016,10.1016/j.anireprosci.2016.05.002,https://pubmed.ncbi.nlm.nih.gov/27236378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,21965014,"Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function.",2011,10.1164/rccm.201102-0192oc,https://pubmed.ncbi.nlm.nih.gov/21965014/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GSTCD,ENSG00000138780,Unsafe,21659657,The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility.,2011,10.1165/rcmb.2011-0055oc,https://pubmed.ncbi.nlm.nih.gov/21659657/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTF2A1L,ENSG00000242441,Unsafe,40427364,Search for Ancient Selection Traces in Faverolle Chicken Breed (&lt;i&gt;Gallus gallus domesticus&lt;/i&gt;) Based on Runs of Homozygosity Analysis.,2025,10.3390/ani15101487,https://pubmed.ncbi.nlm.nih.gov/40427364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTF2A1L,ENSG00000242441,Unsafe,38672173,Obesity-Dependent Association of the rs10454142 PPP1R21 with Breast Cancer.,2024,10.3390/biomedicines12040818,https://pubmed.ncbi.nlm.nih.gov/38672173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTF2A1L,ENSG00000242441,Unsafe,36506088,Reduced LYNX1 expression in transcriptome of human iPSC-derived neural progenitors modeling fragile X syndrome.,2022,10.3389/fcell.2022.1034679,https://pubmed.ncbi.nlm.nih.gov/36506088/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTF2A1L,ENSG00000242441,Unsafe,23770943,Aberrant methylation of the TDMR of the GTF2A1L promoter does not affect fertilisation rates via TESE in patients with hypospermatogenesis.,2013,10.1038/aja.2013.56,https://pubmed.ncbi.nlm.nih.gov/23770943/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTF2A1L,ENSG00000242441,Unsafe,25374392,"Association of single nucleotide polymorphisms in the USF1, GTF2A1L and OR2W3 genes with non-obstructive azoospermia in the Chinese population.",2015,10.1007/s10815-014-0369-y,https://pubmed.ncbi.nlm.nih.gov/25374392/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTF2A1L,ENSG00000242441,Unsafe,28775256,A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration.,2017,10.1038/s41598-017-07526-9,https://pubmed.ncbi.nlm.nih.gov/28775256/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTF2A1L,ENSG00000242441,Unsafe,26305227,Systems Genetics Reveals the Functional Context of PCOS Loci and Identifies Genetic and Molecular Mechanisms of Disease Heterogeneity.,2015,10.1371/journal.pgen.1005455,https://pubmed.ncbi.nlm.nih.gov/26305227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTF2A1L,ENSG00000242441,Unsafe,16525715,Involvement of ALF in human spermatogenesis and male infertility.,2006,10.3892/ijmm.17.4.599,https://pubmed.ncbi.nlm.nih.gov/16525715/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTF2A1L,ENSG00000242441,Unsafe,10364255,Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis.,1999,10.1074/jbc.274.25.18040,https://pubmed.ncbi.nlm.nih.gov/10364255/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTPBP10,ENSG00000105793,Unsafe,42767572,Metabolic reprogramming of decidual macrophages impairs maternal-fetal interface homeostasis and contributes to recurrent spontaneous abortion.,2026,10.1016/j.bcp.2026.118493,https://pubmed.ncbi.nlm.nih.gov/42767572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTPBP10,ENSG00000105793,Unsafe,35210471,MicroRNA editing patterns in Huntington's disease.,2022,10.1038/s41598-022-06970-6,https://pubmed.ncbi.nlm.nih.gov/35210471/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTPBP10,ENSG00000105793,Unsafe,38042949,Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome.,2023,10.1038/s41467-023-43599-z,https://pubmed.ncbi.nlm.nih.gov/38042949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTPBP10,ENSG00000105793,Unsafe,30321378,Human GTPBP10 is required for mitoribosome maturation.,2018,10.1093/nar/gky938,https://pubmed.ncbi.nlm.nih.gov/30321378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTPBP10,ENSG00000105793,Unsafe,35320117,Pan-cancer analysis revealed the significance of the GTPBP family in cancer.,2022,10.18632/aging.203952,https://pubmed.ncbi.nlm.nih.gov/35320117/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTPBP10,ENSG00000105793,Unsafe,36595475,A comprehensive landscape of transcription profiles and data resources for human leukemia.,2023,10.1182/bloodadvances.2022008410,https://pubmed.ncbi.nlm.nih.gov/36595475/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTPBP10,ENSG00000105793,Unsafe,32735630,RCC1L (WBSCR16) isoforms coordinate mitochondrial ribosome assembly through their interaction with GTPases.,2020,10.1371/journal.pgen.1008923,https://pubmed.ncbi.nlm.nih.gov/32735630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTPBP10,ENSG00000105793,Unsafe,30085210,The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis.,2018,10.1093/nar/gky701,https://pubmed.ncbi.nlm.nih.gov/30085210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTPBP10,ENSG00000105793,Unsafe,34315873,A distinct assembly pathway of the human 39S late pre-mitoribosome.,2021,10.1038/s41467-021-24818-x,https://pubmed.ncbi.nlm.nih.gov/34315873/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTPBP10,ENSG00000105793,Unsafe,33264405,Dual function of GTPBP6 in biogenesis and recycling of human mitochondrial ribosomes.,2020,10.1093/nar/gkaa1132,https://pubmed.ncbi.nlm.nih.gov/33264405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTPBP10,ENSG00000105793,Unsafe,32652011,Human GTPBP5 (MTG2) fuels mitoribosome large subunit maturation by facilitating 16S rRNA methylation.,2020,10.1093/nar/gkaa592,https://pubmed.ncbi.nlm.nih.gov/32652011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTPBP10,ENSG00000105793,Unsafe,26863628,Integrative radiogenomic analysis for multicentric radiophenotype in glioblastoma.,2016,10.18632/oncotarget.7115,https://pubmed.ncbi.nlm.nih.gov/26863628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTPBP10,ENSG00000105793,Unsafe,27409348,Identification and validation of regulatory SNPs that modulate transcription factor chromatin binding and gene expression in prostate cancer.,2016,10.18632/oncotarget.10520,https://pubmed.ncbi.nlm.nih.gov/27409348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,41866755,The MYBL2-GTSE1 axis promotes laryngeal squamous cell carcinoma progression by regulating PI3K/AKT-dependent glycolytic reprogramming.,2026,10.1080/15384047.2026.2648193,https://pubmed.ncbi.nlm.nih.gov/41866755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,42278425,45A ncRNA Expression Leads to Chromosomal Instability and Cytoskeletal Dynamics Impairment by Modulating GTSE1/p53/AurB Subcellular Localization.,2026,10.3390/ijms27114892,https://pubmed.ncbi.nlm.nih.gov/42278425/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,41668065,EIF3B regulates the cell cycle of lung adenocarcinoma cells by activating the GTSE1 mediated ERK/MAPK pathway.,2026,10.1186/s12931-026-03559-9,https://pubmed.ncbi.nlm.nih.gov/41668065/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,40405148,METTL16 accelerates lung adenocarcinoma progression by inducing N6-methyladenosine modification of GTSE1 to regulate p53 pathway and cell cycle.,2025,10.1186/s13008-025-00156-y,https://pubmed.ncbi.nlm.nih.gov/40405148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,42852766,"Identification and Functional Characterization of CDK1, CCNB1, CCNB2, RRM2, and GTSE1 Associated with Replicative Senescence of Human Umbilical Cord-Derived Mesenchymal Stem Cells.",2026,10.2174/011574888x508076260925100358,https://pubmed.ncbi.nlm.nih.gov/42852766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,39342428,GTSE1-driven ZEB1 stabilization promotes pulmonary fibrosis through the epithelial-to-mesenchymal transition.,2024,10.1016/j.ymthe.2024.09.029,https://pubmed.ncbi.nlm.nih.gov/39342428/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,40272409,Stabilization of GTSE1 by cyclin D1-CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosis.,2025,10.7554/elife.101075,https://pubmed.ncbi.nlm.nih.gov/40272409/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,42301774,The physiological relevance of downstream effectors of p53 activity.,2026,10.1073/pnas.2536303123,https://pubmed.ncbi.nlm.nih.gov/42301774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,39629227,"Comprehensive analysis of the diagnostic and therapeutic value, immune infiltration, and drug treatment mechanisms of GTSE1 in lung adenocarcinoma.",2024,10.3389/fmed.2024.1433601,https://pubmed.ncbi.nlm.nih.gov/39629227/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,38715380,GTSE1: A potential prognostic and diagnostic biomarker in various tumors including lung adenocarcinoma.,2024,10.1111/crj.13757,https://pubmed.ncbi.nlm.nih.gov/38715380/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,38518054,G2 and S phase-expressed protein 1 is a biomarker for poor prognosis in lung adenocarcinoma.,2024,10.1097/md.0000000000037358,https://pubmed.ncbi.nlm.nih.gov/38518054/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,40831537,GTSE1-expressed osteoblastic cells facilitate formation of pro-metastatic tumor microenvironment in osteosarcoma.,2025,10.1016/j.gendis.2025.101591,https://pubmed.ncbi.nlm.nih.gov/40831537/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,42431167,An integrated genetic approach prioritizes closely linked candidate genes underlying an open-field behavior QTL on chicken chromosome 1.,2026,10.1016/j.psj.2026.107390,https://pubmed.ncbi.nlm.nih.gov/42431167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,42335766,Single-cell transcriptome profiling of primordial germ cells reveals differences between right and left gonads in chickens.,2026,10.1016/j.psj.2026.107247,https://pubmed.ncbi.nlm.nih.gov/42335766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,38774096,Novel cancer-fighting role of ticagrelor inhibits GTSE1-induced EMT by regulating PI3K/Akt/NF-κB signaling pathway in malignant glioma.,2024,10.1016/j.heliyon.2024.e30833,https://pubmed.ncbi.nlm.nih.gov/38774096/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,37653815,Pan-cancer analyses reveal GTSE1 as a biomarker for the immunosuppressive tumor microenvironment.,2023,10.1097/md.0000000000034996,https://pubmed.ncbi.nlm.nih.gov/37653815/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,39068590,The Overexpression of NUSAP1 and GTSE1 Could Predict An Unfavourable Prognosis and Shorter Disease Free Survival in ccRenal Cell Carcinoma.,2024,10.31557/apjcp.2024.25.7.2551,https://pubmed.ncbi.nlm.nih.gov/39068590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,38698443,GTSE1 promotes nasopharyngeal carcinoma proliferation and angiogenesis by upregulating STMN1.,2024,10.1186/s13008-024-00119-9,https://pubmed.ncbi.nlm.nih.gov/38698443/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,39154935,Engineered lipid nanoparticles enable therapeutic gene silencing of GTSE1 for the treatment of liver fibrosis.,2024,10.1016/j.jconrel.2024.08.012,https://pubmed.ncbi.nlm.nih.gov/39154935/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,41857699,A dual-mechanism model of Selinexor in DLBCL: p53 reactivation and metabolic reprogramming.,2026,10.1186/s12967-026-08014-3,https://pubmed.ncbi.nlm.nih.gov/41857699/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,41902775,Evolution of Aptamer Materials Maps Exosomal Surface Proteins at the Nano-Bio Interface.,2026,10.1021/acs.nanolett.6c00387,https://pubmed.ncbi.nlm.nih.gov/41902775/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,36999057,"High GTSE1 expression promotes cell proliferation, metastasis and cisplatin resistance in ccRCC and is associated with immune infiltrates and poor prognosis.",2023,10.3389/fgene.2023.996362,https://pubmed.ncbi.nlm.nih.gov/36999057/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,40273626,"Vitamin K2 mitigates cognitive, and motor impairments induced by multiple surgery with anesthesia and analgesia in neonatal stage.",2025,10.1016/j.bbrc.2025.151784,https://pubmed.ncbi.nlm.nih.gov/40273626/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,38617927,Characterization of a G2M checkpoint-related gene model and subtypes associated with immunotherapy response for clear cell renal cell carcinoma.,2024,10.1016/j.heliyon.2024.e29289,https://pubmed.ncbi.nlm.nih.gov/38617927/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,35912542,CTPS1 inhibition suppresses proliferation and migration in colorectal cancer cells.,2022,10.1080/15384101.2022.2105084,https://pubmed.ncbi.nlm.nih.gov/35912542/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,39940790,Identification of MCM2-Interacting Proteins Associated with Replication Initiation Using APEX2-Based Proximity Labeling Technology.,2025,10.3390/ijms26031020,https://pubmed.ncbi.nlm.nih.gov/39940790/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,32202046,Knockdown GTSE1 enhances radiosensitivity in non-small-cell lung cancer through DNA damage repair pathway.,2020,10.1111/jcmm.15165,https://pubmed.ncbi.nlm.nih.gov/32202046/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSE1,ENSG00000075218,Unsafe,32082966,"GTSE1, CDC20, PCNA, and MCM6 Synergistically Affect Regulations in Cell Cycle and Indicate Poor Prognosis in Liver Cancer.",2019,10.1155/2019/1038069,https://pubmed.ncbi.nlm.nih.gov/32082966/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,42162075,Uncovering hidden spermatogenesis: INPP1 and GTSF1 as non-invasive predictors of sperm retrieval in non-obstructive azoospermia.,2026,10.1038/s41598-026-47513-7,https://pubmed.ncbi.nlm.nih.gov/42162075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,42652500,Gametocyte-Specific Factor 1 Is Essential for Male Fertility and Transposon Homeostasis in &lt;i&gt;Plutella xylostella&lt;/i&gt;.,2026,10.3390/insects17080846,https://pubmed.ncbi.nlm.nih.gov/42652500/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,40369846,Memory T-Cell Phenotype in Cutaneous T-Cell Lymphoma Is Modified by Germline Gene Gametocyte Specific Factor 1.,2025,10.1111/exd.70123,https://pubmed.ncbi.nlm.nih.gov/40369846/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,41344056,piR-43452 suppresses bladder cancer progression and enhances gemcitabine sensitivity via GTSF1/PIWIL4-mediated LRP1 mRNA destabilization.,2026,10.1016/j.tranon.2025.102626,https://pubmed.ncbi.nlm.nih.gov/41344056/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,40786706,Single-cell RNA and bulk sequencing analysis reveals that formononetin inhibits GTSF1 to exert anti-osteosarcoma effects.,2025,10.1063/5.0266780,https://pubmed.ncbi.nlm.nih.gov/40786706/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,40520861,GTSF1 promotes stemness in uterine carcinosarcoma through CCL1-mediated M1 macrophage aggregation.,2025,10.62347/maxh5742,https://pubmed.ncbi.nlm.nih.gov/40520861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,40912244,A conserved PIWI silencing complex detects piRNA-target engagement.,2025,10.1016/j.molcel.2025.08.010,https://pubmed.ncbi.nlm.nih.gov/40912244/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,40493187,Abundant piRNA production mediated by the &lt;i&gt;Drosophila&lt;/i&gt; GTSF1 homolog Tpp ensures Aubergine localization and germ plasm assembly.,2025,10.1073/pnas.2419375122,https://pubmed.ncbi.nlm.nih.gov/40493187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,41528842,Structure of the MIWI endoribonuclease bound to pachytene piRNAs from mouse testes.,2026,10.1016/j.celrep.2025.116804,https://pubmed.ncbi.nlm.nih.gov/41528842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,42668316,An evolutionarily conserved N-terminal domain of RRF-3 governs GTSF-1 binding in nematodes.,2026,10.1038/s44319-026-00914-1,https://pubmed.ncbi.nlm.nih.gov/42668316/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,39966702,Comprehensive analysis of long non-coding RNA and mRNA expression patterns during seminiferous tubules maturation in Guanzhong dairy goats.,2025,10.1186/s12864-025-11320-7,https://pubmed.ncbi.nlm.nih.gov/39966702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,41784387,Positive Selection Targeted Primate Genes that Encode Transposable Element Repressors.,2026,10.1093/gbe/evag059,https://pubmed.ncbi.nlm.nih.gov/41784387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,39122675,"Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertility.",2024,10.1038/s41467-024-50930-9,https://pubmed.ncbi.nlm.nih.gov/39122675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,39441077,GTSF1 is required for transposon silencing in the unicellular eukaryote Paramecium tetraurelia.,2024,10.1093/nar/gkae925,https://pubmed.ncbi.nlm.nih.gov/39441077/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,39571614,The PIWI-interacting protein Gtsf1 controls the selective degradation of small RNAs in Paramecium.,2025,10.1093/nar/gkae1055,https://pubmed.ncbi.nlm.nih.gov/39571614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,42038475,Multi-omics analysis reveals key genes associated with clear cell renal cell carcinoma.,2026,10.7717/peerj.21057,https://pubmed.ncbi.nlm.nih.gov/42038475/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,40077805,Depletion of Gtsf1L impairs development of eupyrene sperm and ovary in Bombyx mori.,2025,10.1111/imb.12988,https://pubmed.ncbi.nlm.nih.gov/40077805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,39814893,Structural insights into RNA cleavage by PIWI Argonaute.,2025,10.1038/s41586-024-08438-1,https://pubmed.ncbi.nlm.nih.gov/39814893/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,35108755,Developmental roles and molecular mechanisms of Asterix/GTSF1.,2022,10.1002/wrna.1716,https://pubmed.ncbi.nlm.nih.gov/35108755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,39980308,Transcriptomic Profiles for Elucidating Response of Bladder Intracavitary Hyperthermic Perfusion Chemotherapy in High-Risk Nonmuscular Invasive Bladder Cancer.,2025,10.1002/cam4.70672,https://pubmed.ncbi.nlm.nih.gov/39980308/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,40687263,Retrospective prognostic evaluation and single-cell transcriptomic analyses of non-small cell lung carcinoma with malignant pleural effusion.,2025,10.21037/tcr-2024-2581,https://pubmed.ncbi.nlm.nih.gov/40687263/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,39141072,Mechanism exploration of synergistic photo-immunotherapy strategy based on a novel exosome-like nanosystem for remodeling the immune microenvironment of HCC.,2024,10.1186/s40580-024-00441-6,https://pubmed.ncbi.nlm.nih.gov/39141072/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,33310860,Piwi suppresses transcription of Brahma-dependent transposons via Maelstrom in ovarian somatic cells.,2020,10.1126/sciadv.aaz7420,https://pubmed.ncbi.nlm.nih.gov/33310860/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,34528236,Transcriptomic changes during stage progression of mycosis fungoides.,2022,10.1111/bjd.20760,https://pubmed.ncbi.nlm.nih.gov/34528236/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,24850846,Ectopic expression of cancer-testis antigens in cutaneous T-cell lymphoma patients.,2014,10.1158/1078-0432.ccr-14-0307,https://pubmed.ncbi.nlm.nih.gov/24850846/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,28638728,Gene expression analysis in Cutaneous T-Cell Lymphomas (CTCL) highlights disease heterogeneity and potential diagnostic and prognostic indicators.,2017,10.1080/2162402x.2017.1306618,https://pubmed.ncbi.nlm.nih.gov/28638728/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,25779945,The Use of Transcriptional Profiling to Improve Personalized Diagnosis and Management of Cutaneous T-cell Lymphoma (CTCL).,2015,10.1158/1078-0432.ccr-14-3322,https://pubmed.ncbi.nlm.nih.gov/25779945/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,22513784,A meta-analysis of gene expression data identifies a molecular signature characteristic for tumor-stage mycosis fungoides.,2012,10.1038/jid.2012.117,https://pubmed.ncbi.nlm.nih.gov/22513784/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GTSF1,ENSG00000170627,Unsafe,23936488,Gene expression profiling of histiocytic sarcomas in a canine model: the predisposed flatcoated retriever dog.,2013,10.1371/journal.pone.0071094,https://pubmed.ncbi.nlm.nih.gov/23936488/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,42869145,Protein inhibitor of retinal membrane guanylyl cyclase rescues photoreceptors from degeneration induced by mutated guanylyl cyclase activating protein.,2026,10.1016/j.jbc.2026.113636,https://pubmed.ncbi.nlm.nih.gov/42869145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,40962054,Protein inhibitor of retinal membrane guanylyl cyclase suppresses cGMP synthesis in photoreceptors.,2025,10.1016/j.jbc.2025.110718,https://pubmed.ncbi.nlm.nih.gov/40962054/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,41448181,Rebalancing NTRK2 isoforms promotes vascular regeneration in bronchopulmonary dysplasia.,2026,10.1016/j.stem.2025.12.006,https://pubmed.ncbi.nlm.nih.gov/41448181/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,42057040,Comprehensive multiomics analyses identify guanylate cyclase activator 1A as a photoreceptor-specific target in a murine model of oxygen-induced retinopathy.,2026,10.1186/s12967-026-08207-w,https://pubmed.ncbi.nlm.nih.gov/42057040/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,42299446,Circulating Protein-Mediated Pathways in Basal Cell Carcinoma: Mendelian Randomization Reveals STAT3 and GUCA1A as Key Regulatory Hubs.,2026,10.2147/ccid.s597844,https://pubmed.ncbi.nlm.nih.gov/42299446/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,42085217,Mast cells and endothelial cells mediate interleukin-33 and ST2 responses in distal chronic obstructive pulmonary disease lungs.,2026,10.1093/ajrccm/aamag079,https://pubmed.ncbi.nlm.nih.gov/42085217/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,42873417,Early emergence of inter-lobar heterogeneity in mouse embryonic lung.,2026,10.1186/s13619-026-00303-y,https://pubmed.ncbi.nlm.nih.gov/42873417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,41819313,Structural and functional investigation of RD3-GCAP1 interaction in retinal photoreceptors under normal and disease conditions.,2026,10.1016/j.ijbiomac.2026.151333,https://pubmed.ncbi.nlm.nih.gov/41819313/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,39909376,Phosphodiesterase 5 expression in photoreceptors rescues retinal degeneration induced by deregulation of membrane guanylyl cyclase.,2025,10.1016/j.jbc.2025.108265,https://pubmed.ncbi.nlm.nih.gov/39909376/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,42727837,HIF-2α-mediated PLVAP suppression in gCap drives immune infiltration in chronic hypoxia-induced pulmonary edema.,2026,10.1016/j.cellsig.2026.112888,https://pubmed.ncbi.nlm.nih.gov/42727837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,42331110,The C-terminal domain of RD3 enables accumulation of retinal membrane guanylyl cyclase (RetGC) in photoreceptor outer segment.,2026,10.1016/j.jbc.2026.113277,https://pubmed.ncbi.nlm.nih.gov/42331110/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,40917842,New perspectives on the progression of pulmonary fibrosis: the cascade from aberrant microvascular endothelial cell activation to fibrosis.,2025,10.3389/fmed.2025.1639043,https://pubmed.ncbi.nlm.nih.gov/40917842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,41468121,Can We Develop Glioma Subtype-Specific Precision Medicines? An Integrative Machine Learning Pipeline for Biomarker Discovery and Drug Repurposing for Glioblastoma and Low-Grade Glioma.,2026,10.1177/15578100251408278,https://pubmed.ncbi.nlm.nih.gov/41468121/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,41500346,Protein delivery to the eye: assessing therapeutic potential across inner and outer retina.,2026,10.1016/j.ijpharm.2026.126568,https://pubmed.ncbi.nlm.nih.gov/41500346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,40125780,TrkB signaling promotes alveolar capillary angiogenesis following perinatal hyperoxic damage.,2025,10.1152/ajplung.00334.2023,https://pubmed.ncbi.nlm.nih.gov/40125780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,40013354,Monogenic Retinal Diseases Associated With Genes Encoding Phototransduction Proteins: A Review.,2025,10.1111/ceo.14511,https://pubmed.ncbi.nlm.nih.gov/40013354/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,31882816,Normal GCAPs partly compensate for altered cGMP signaling in retinal dystrophies associated with mutations in GUCA1A.,2019,10.1038/s41598-019-56606-5,https://pubmed.ncbi.nlm.nih.gov/31882816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,39969478,"Clinical, Genetic, Imaging and Electrophysiological Findings in a Cohort of Patients With GUCA1A-Associated Retinopathy.",2025,10.1167/iovs.66.2.50,https://pubmed.ncbi.nlm.nih.gov/39969478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,39286023,Identification and validation of potential prognostic biomarkers in glioblastoma via the mesenchymal stem cell infiltration level.,2024,10.3389/fonc.2024.1406186,https://pubmed.ncbi.nlm.nih.gov/39286023/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,37008786,Evolution of visual guanylyl cyclases and their activating proteins with respect to clade and species-specific visual system adaptation.,2023,10.3389/fnmol.2023.1131093,https://pubmed.ncbi.nlm.nih.gov/37008786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,38373991,Machine learning-based extrachromosomal DNA identification in large-scale cohorts reveals its clinical implications in cancer.,2024,10.1038/s41467-024-45479-6,https://pubmed.ncbi.nlm.nih.gov/38373991/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,37620651,Identifying the serious clinical outcomes of adverse reactions to drugs by a multi-task deep learning framework.,2023,10.1038/s42003-023-05243-w,https://pubmed.ncbi.nlm.nih.gov/37620651/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,38001384,Recombinant protein delivery enables modulation of the phototransduction cascade in mouse retina.,2023,10.1007/s00018-023-05022-0,https://pubmed.ncbi.nlm.nih.gov/38001384/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,34072225,Usefulness of a Colonoscopy Cap with an External Grid for the Measurement of Small-Sized Colorectal Polyps: A Prospective Randomized Trial.,2021,10.3390/jcm10112365,https://pubmed.ncbi.nlm.nih.gov/34072225/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,39175413,Allosteric Communication of the Dimerization and the Catalytic Domain in Photoreceptor Guanylate Cyclase.,2024,10.1021/acs.biochem.4c00170,https://pubmed.ncbi.nlm.nih.gov/39175413/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,36467073,Deficiency of endothelial FGFR1 alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice.,2022,10.3389/fphar.2022.1039103,https://pubmed.ncbi.nlm.nih.gov/36467073/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,32999240,Rapidly Progressing Aseptic Abscesses in a Patient with Ulcerative Colitis.,2021,10.2169/internalmedicine.5733-20,https://pubmed.ncbi.nlm.nih.gov/32999240/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,29440717,Molecular determinants of Guanylate Cyclase Activating Protein subcellular distribution in photoreceptor cells of the retina.,2018,10.1038/s41598-018-20893-1,https://pubmed.ncbi.nlm.nih.gov/29440717/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,28125083,GUCA1A mutation causes maculopathy in a five-generation family with a wide spectrum of severity.,2017,10.1038/gim.2016.217,https://pubmed.ncbi.nlm.nih.gov/28125083/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,35879310,Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis.,2022,10.1038/s41467-022-31890-4,https://pubmed.ncbi.nlm.nih.gov/35879310/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,30255496,Global Capnography Project (GCAP): implementation of capnography in Malawi - an international anaesthesia quality improvement project.,2019,10.1111/anae.14426,https://pubmed.ncbi.nlm.nih.gov/30255496/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,23082185,Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice.,2012,10.1371/journal.pone.0047637,https://pubmed.ncbi.nlm.nih.gov/23082185/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,36283964,Remarkable sex-specific differences at single-cell resolution in neonatal hyperoxic lung injury.,2023,10.1152/ajplung.00269.2022,https://pubmed.ncbi.nlm.nih.gov/36283964/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,33928237,Retinal imaging in inherited retinal diseases.,2020,10.21037/aes-20-81,https://pubmed.ncbi.nlm.nih.gov/33928237/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,24352742,Disease progression in autosomal dominant cone-rod dystrophy caused by a novel mutation (D100G) in the GUCA1A gene.,2014,10.1007/s10633-013-9420-z,https://pubmed.ncbi.nlm.nih.gov/24352742/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCA1A,ENSG00000048545,Unsafe,9620085,The localization of guanylyl cyclase-activating proteins in the mammalian retina.,1998,,https://pubmed.ncbi.nlm.nih.gov/9620085/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,42510828,Developmental and Light-Induced Expression Patterns of Phototransduction Pathway Genes in Large Yellow Croaker (&lt;i&gt;Larimichthys crocea&lt;/i&gt;).,2026,10.3390/genes17070788,https://pubmed.ncbi.nlm.nih.gov/42510828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,42685483,Transcriptomics reveals the gene expression dynamics during embryonic development of largemouth bass (Micropterus nigricans) at the endogenous nutrition stage.,2026,10.1016/j.cbd.2026.101994,https://pubmed.ncbi.nlm.nih.gov/42685483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,41751868,Exome-Wide Association Analysis Identifies Rare Germline Susceptibility Variants in Early-Onset Breast Cancer Among Saudi Women.,2026,10.3390/ijms27041732,https://pubmed.ncbi.nlm.nih.gov/41751868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,37361352,Development of an AAV-CRISPR-Cas9-based treatment for dominant cone-rod dystrophy 6.,2023,10.1016/j.omtm.2023.05.020,https://pubmed.ncbi.nlm.nih.gov/37361352/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,36292254,Pulmonary Hypertension Associated Genetic Variants in Sarcoidosis Associated Pulmonary Hypertension.,2022,10.3390/diagnostics12102564,https://pubmed.ncbi.nlm.nih.gov/36292254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,37008786,Evolution of visual guanylyl cyclases and their activating proteins with respect to clade and species-specific visual system adaptation.,2023,10.3389/fnmol.2023.1131093,https://pubmed.ncbi.nlm.nih.gov/37008786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,21598940,Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors.,2011,10.1021/bi200491b,https://pubmed.ncbi.nlm.nih.gov/21598940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,34537244,Retinal degeneration-3 protein attenuates photoreceptor degeneration in transgenic mice expressing dominant mutation of human retinal guanylyl cyclase.,2021,10.1016/j.jbc.2021.101201,https://pubmed.ncbi.nlm.nih.gov/34537244/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,30069494,Inferring Novel Tumor Suppressor Genes with a Protein-Protein Interaction Network and Network Diffusion Algorithms.,2018,10.1016/j.omtm.2018.06.007,https://pubmed.ncbi.nlm.nih.gov/30069494/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,36157073,Structural basis of retinal membrane guanylate cyclase regulation by GCAP1 and RD3.,2022,10.3389/fnmol.2022.988142,https://pubmed.ncbi.nlm.nih.gov/36157073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,33919796,Impaired Ca2+ Sensitivity of a Novel GCAP1 Variant Causes Cone Dystrophy and Leads to Abnormal Synaptic Transmission Between Photoreceptors and Bipolar Cells.,2021,10.3390/ijms22084030,https://pubmed.ncbi.nlm.nih.gov/33919796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,33887693,Determination of the key ccRCC-related molecules from monolayer network to three-layer network.,2021,10.1016/j.cancergen.2021.03.005,https://pubmed.ncbi.nlm.nih.gov/33887693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,22623665,Retinal guanylyl cyclase isozyme 1 is the preferential in vivo target for constitutively active GCAP1 mutants causing congenital degeneration of photoreceptors.,2012,10.1523/jneurosci.0976-12.2012,https://pubmed.ncbi.nlm.nih.gov/22623665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,22378290,Gucy2f zebrafish knockdown--a model for Gucy2d-related leber congenital amaurosis.,2012,10.1038/ejhg.2012.10,https://pubmed.ncbi.nlm.nih.gov/22378290/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,28329817,Early-Life Benzo[a]Pyrene Exposure Causes Neurodegenerative Syndromes in Adult Zebrafish (Danio rerio) and the Mechanism Involved.,2017,10.1093/toxsci/kfx028,https://pubmed.ncbi.nlm.nih.gov/28329817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,23210611,AAV-mediated gene therapy in the guanylate cyclase (RetGC1/RetGC2) double knockout mouse model of Leber congenital amaurosis.,2013,10.1089/hum.2012.193,https://pubmed.ncbi.nlm.nih.gov/23210611/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,23082185,Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice.,2012,10.1371/journal.pone.0047637,https://pubmed.ncbi.nlm.nih.gov/23082185/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,20012162,Novel functions of photoreceptor guanylate cyclases revealed by targeted deletion.,2010,10.1007/s11010-009-0322-z,https://pubmed.ncbi.nlm.nih.gov/20012162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,25616661,Evaluating the role of retinal membrane guanylyl cyclase 1 (RetGC1) domains in binding guanylyl cyclase-activating proteins (GCAPs).,2015,10.1074/jbc.m114.629642,https://pubmed.ncbi.nlm.nih.gov/25616661/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,24860425,Insights gained from gene therapy in animal models of retGC1 deficiency.,2014,10.3389/fnmol.2014.00043,https://pubmed.ncbi.nlm.nih.gov/24860425/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,17949773,A model for transport of membrane-associated phototransduction polypeptides in rod and cone photoreceptor inner segments.,2008,10.1016/j.visres.2007.08.020,https://pubmed.ncbi.nlm.nih.gov/17949773/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
GUCY2F,ENSG00000101890,Unsafe,7777544,"Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2.",1995,10.1073/pnas.92.12.5535,https://pubmed.ncbi.nlm.nih.gov/7777544/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,40104216,Unveiling racial disparities in prostate cancer using an integrative genomic and transcriptomic analysis.,2025,10.1016/j.cellin.2025.100238,https://pubmed.ncbi.nlm.nih.gov/40104216/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,41858377,CANT1 as a novel prognostic biomarker in triple-negative breast cancer.,2026,10.3892/ol.2026.15519,https://pubmed.ncbi.nlm.nih.gov/41858377/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,41614924,Ensemble Machine Learning on Bulk RNA-Seq Identifies 17-Gene Signature Predicting Neoadjuvant Chemotherapy Response in Breast Cancer.,2026,10.3390/cimb48010094,https://pubmed.ncbi.nlm.nih.gov/41614924/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,41225847,Characterization of &lt;i&gt;Caleosin&lt;/i&gt; Genes in &lt;i&gt;Carica papaya&lt;/i&gt; and Insights into Lineage-Specific Family Evolution in Brassicales.,2025,10.3390/plants14213296,https://pubmed.ncbi.nlm.nih.gov/41225847/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,40368256,Trichilia silvatica extracts modulate the oxinflammatory response: an in vitro analysis.,2025,10.1016/j.jep.2025.119973,https://pubmed.ncbi.nlm.nih.gov/40368256/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,41214392,Novel voriconazole-loaded hyalurosomes optimized for enhanced skin penetration and antifungal activity against Candida albicans.,2026,10.1007/s13346-025-02007-3,https://pubmed.ncbi.nlm.nih.gov/41214392/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,37385390,Epigenetic alternations and targeted therapy in intrauterine adhesion: A comparative study.,2023,10.1016/j.ygeno.2023.110673,https://pubmed.ncbi.nlm.nih.gov/37385390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,29983878,Prostate cancer susceptibility gene HIST1H1A is a modulator of androgen receptor signaling and epithelial to mesenchymal transition.,2018,10.18632/oncotarget.25536,https://pubmed.ncbi.nlm.nih.gov/29983878/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,34946949,Spatial and Temporal Expression of High-Mobility-Group Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with Cognition in Individuals with Down Syndrome.,2021,10.3390/genes12122000,https://pubmed.ncbi.nlm.nih.gov/34946949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,41856620,[Study on the characteristics and differences of intestinal microbiota in children with allergic diseases].,2026,10.3760/cma.j.cn112150-20251015-00988,https://pubmed.ncbi.nlm.nih.gov/41856620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,36164372,E2F1 Affects the Therapeutic Response to Neoadjuvant Therapy in Breast Cancer.,2022,10.1155/2022/8168517,https://pubmed.ncbi.nlm.nih.gov/36164372/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,34663856,"Brain age estimation at tract group level and its association with daily life measures, cardiac risk factors and genetic variants.",2021,10.1038/s41598-021-99153-8,https://pubmed.ncbi.nlm.nih.gov/34663856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,40772459,Affordable Non-Invasive Machine-Aided Phenotyping Identifies Phenotypic Variation to Soil Stress Across the Arabidopsis thaliana Life Cycle.,2025,10.1111/ppl.70427,https://pubmed.ncbi.nlm.nih.gov/40772459/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,39002312,Proteome overview of exosome derived from plasma of cows infected with Mycobacterium bovis.,2024,10.1016/j.tube.2024.102541,https://pubmed.ncbi.nlm.nih.gov/39002312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,38921546,Methanolic Extract and Brominated Compound from the Brazilian Marine Sponge Aplysina fulva Are Neuroprotective and Modulate Inflammatory Profile of Microglia.,2024,10.3390/md22060235,https://pubmed.ncbi.nlm.nih.gov/38921546/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,34745064,"Nitrogeniibacter aestuarii sp. nov., a Novel Nitrogen-Fixing Bacterium Affiliated to the Family Zoogloeaceae and Phylogeny of the Family Zoogloeaceae Revisited.",2021,10.3389/fmicb.2021.755908,https://pubmed.ncbi.nlm.nih.gov/34745064/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,29382826,Ubiquitin C decrement plays a pivotal role in replicative senescence of bone marrow mesenchymal stromal cells.,2018,10.1038/s41419-017-0032-5,https://pubmed.ncbi.nlm.nih.gov/29382826/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,32518846,Multifunctional properties of spherical silver nanoparticles fabricated by different microbial taxa.,2020,10.1016/j.heliyon.2020.e03943,https://pubmed.ncbi.nlm.nih.gov/32518846/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,36551476,In Vitro Assessment of Antimicrobial Activity of Phytobiotics Composition towards of Avian Pathogenic Escherichia coli (APEC) and Other E. coli Strains Isolated from Broiler Chickens.,2022,10.3390/antibiotics11121818,https://pubmed.ncbi.nlm.nih.gov/36551476/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,25302706,Transcriptome analysis reveals the contribution of thermal and the specific effects in cellular response to millimeter wave exposure.,2014,10.1371/journal.pone.0109435,https://pubmed.ncbi.nlm.nih.gov/25302706/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,42894016,Dynamical signatures of conventional and asymptotic quantum many-body scars on a trapped ion simulator.,2026,10.1038/s41467-026-77411-5,https://pubmed.ncbi.nlm.nih.gov/42894016/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,41339725,Entanglement teleportation along a regenerating hamster-wheel graph state.,2025,10.1038/s41598-025-30301-0,https://pubmed.ncbi.nlm.nih.gov/41339725/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,37289995,Modeling Singlet Fission on a Quantum Computer.,2023,10.1021/acs.jpclett.3c01106,https://pubmed.ncbi.nlm.nih.gov/37289995/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,34896172,Iron oxide nanoparticles doped biochar ameliorates trace elements induced phytotoxicity in tomato by modulation of physiological and biochemical responses: Implications for human health risk.,2022,10.1016/j.chemosphere.2021.133203,https://pubmed.ncbi.nlm.nih.gov/34896172/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,22532829,Single endemic genotype of measles virus continuously circulating in China for at least 16 years.,2012,10.1371/journal.pone.0034401,https://pubmed.ncbi.nlm.nih.gov/22532829/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,25411967,"A systems genetics approach identifies CXCL14, ITGAX, and LPCAT2 as novel aggressive prostate cancer susceptibility genes.",2014,10.1371/journal.pgen.1004809,https://pubmed.ncbi.nlm.nih.gov/25411967/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-1,ENSG00000124610,Unsafe,1079346,Thymus-derived rat lymphocyte receptor for cell surface antigens is a nonserologically defined product of the major histocompatibility gene complex.,1975,10.1073/pnas.72.3.1147,https://pubmed.ncbi.nlm.nih.gov/1079346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-7,ENSG00000187166,Unsafe,42816179,Epigenetic role of miR-574 in sperm chromatin remodeling and developmental gene networks in male infertility.,2026,10.1071/rd26110,https://pubmed.ncbi.nlm.nih.gov/42816179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-7,ENSG00000187166,Unsafe,40210827,Associations of epigenetic aging and COVID- 19: A 3-year longitudinal study.,2025,10.1007/s11357-025-01635-4,https://pubmed.ncbi.nlm.nih.gov/40210827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-7,ENSG00000187166,Unsafe,29673127,Cstf2t Regulates expression of histones and histone-like proteins in male germ cells.,2018,10.1111/andr.12488,https://pubmed.ncbi.nlm.nih.gov/29673127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-7,ENSG00000187166,Unsafe,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-7,ENSG00000187166,Unsafe,33407810,Genome-wide occupancy reveals the localization of H1T2 (H1fnt) to repeat regions and a subset of transcriptionally active chromatin domains in rat spermatids.,2021,10.1186/s13072-020-00376-2,https://pubmed.ncbi.nlm.nih.gov/33407810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-7,ENSG00000187166,Unsafe,39774465,Evidence of avian and human influenza A virus infection in farmed Siamese crocodiles (Crocodylus siamensis) in Thailand.,2025,10.1371/journal.pone.0317035,https://pubmed.ncbi.nlm.nih.gov/39774465/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-7,ENSG00000187166,Unsafe,18987332,"HMGB4, a novel member of the HMGB family, is preferentially expressed in the mouse testis and localizes to the basal pole of elongating spermatids.",2009,10.1095/biolreprod.108.070243,https://pubmed.ncbi.nlm.nih.gov/18987332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-7,ENSG00000187166,Unsafe,35145529,Responses of Barley to High Ambient Temperature Are Modulated by Vernalization.,2021,10.3389/fpls.2021.776982,https://pubmed.ncbi.nlm.nih.gov/35145529/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-7,ENSG00000187166,Unsafe,16055721,"HANP1/H1T2, a novel histone H1-like protein involved in nuclear formation and sperm fertility.",2005,10.1128/mcb.25.16.7107-7119.2005,https://pubmed.ncbi.nlm.nih.gov/16055721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-7,ENSG00000187166,Unsafe,16533358,Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein.,2006,10.1111/j.1365-2605.2005.00600.x,https://pubmed.ncbi.nlm.nih.gov/16533358/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-7,ENSG00000187166,Unsafe,18614164,Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation.,2008,10.1016/j.ydbio.2008.05.553,https://pubmed.ncbi.nlm.nih.gov/18614164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-7,ENSG00000187166,Unsafe,22020252,The first bromodomain of the testis-specific double bromodomain protein Brdt is required for chromocenter organization that is modulated by genetic background.,2011,10.1016/j.ydbio.2011.10.005,https://pubmed.ncbi.nlm.nih.gov/22020252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-7,ENSG00000187166,Unsafe,32548133,Extraction and Detection of Avian Influenza Virus From Wetland Sediment Using Enrichment-Based Targeted Resequencing.,2020,10.3389/fvets.2020.00301,https://pubmed.ncbi.nlm.nih.gov/32548133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-7,ENSG00000187166,Unsafe,1849550,Binding of brain and atrial natriuretic peptides to cultured mouse astrocytes and effect on cyclic GMP.,1991,10.1111/j.1471-4159.1991.tb02068.x,https://pubmed.ncbi.nlm.nih.gov/1849550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-7,ENSG00000187166,Unsafe,19396472,Impairment of mitochondrial beta-oxidation in rats under cold-hypoxic environment.,2009,10.1007/s00484-009-0224-5,https://pubmed.ncbi.nlm.nih.gov/19396472/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-7,ENSG00000187166,Unsafe,200911,Studies on the mechanism of phosphorylation of synthetic polypeptides by a calf thymus cyclic AMP-dependent protein kinase.,1977,10.1073/pnas.74.10.4261,https://pubmed.ncbi.nlm.nih.gov/200911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,41456095,A positive feedback loop formed between OsFTIP9 and OSH1 orchestrates temperature-sensitive seed germination in rice.,2026,10.1016/j.molp.2025.12.028,https://pubmed.ncbi.nlm.nih.gov/41456095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,42393842,"A Novel Rice Gene, OsEBR1, Promotes Brassinosteroid Signalling and Is Transcriptionally Repressed by Both OsOFP22 and OsBZR1.",2026,10.1111/pce.70705,https://pubmed.ncbi.nlm.nih.gov/42393842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,41549841,OsPHI-2 Controls Rice Growth and Development Through OSH1-Dependent Transcriptional Repression.,2026,10.1111/ppl.70739,https://pubmed.ncbi.nlm.nih.gov/41549841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,41812483,Liquid-liquid phase separation of OsvWA36 fine-tunes brassinosteroid signaling and leaf angle in rice.,2026,10.1016/j.plaphy.2026.111198,https://pubmed.ncbi.nlm.nih.gov/41812483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,40025368,Heterologous expression of bovine histone H1foo into porcine fibroblasts alters the transcriptome profile but not embryo development following nuclear transfer.,2025,10.1007/s10815-025-03437-1,https://pubmed.ncbi.nlm.nih.gov/40025368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,41928049,"A Novel Homeobox Family Gene, ScH1-33, Promotes Tillering and Enhances Cold Tolerance in Sugarcane.",2026,10.1111/pce.70501,https://pubmed.ncbi.nlm.nih.gov/41928049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,38701780,H1FOO-DD promotes efficiency and uniformity in reprogramming to naive pluripotency.,2024,10.1016/j.stemcr.2024.04.005,https://pubmed.ncbi.nlm.nih.gov/38701780/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,41475621,Implications of early-life BPS-induced thyroid disruption on adult female reproductive disorders.,2026,10.1016/j.cbi.2025.111891,https://pubmed.ncbi.nlm.nih.gov/41475621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,36429134,The Oocyte-Specific Linker Histone H1FOO Is Not Essential for Mouse Oogenesis and Fertility.,2022,10.3390/cells11223706,https://pubmed.ncbi.nlm.nih.gov/36429134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,37642817,Gene expression and demographic analyses in women with the poor ovarian response: a computational approach.,2023,10.1007/s10815-023-02919-4,https://pubmed.ncbi.nlm.nih.gov/37642817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,39481760,Mutation of rice SM1 enhances solid leaf midrib formation and increases methane emissions.,2025,10.1016/j.plantsci.2024.112312,https://pubmed.ncbi.nlm.nih.gov/39481760/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,39514093,SUMOylation of rice DELLA SLR1 modulates transcriptional responses and improves yield under salt stress.,2024,10.1007/s00425-024-04565-1,https://pubmed.ncbi.nlm.nih.gov/39514093/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,36001353,Linker histone H1FOO is required for bovine preimplantation development by regulating lineage specification and chromatin structure†.,2022,10.1093/biolre/ioac167,https://pubmed.ncbi.nlm.nih.gov/36001353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,37384532,The OsbHLH002/OsICE1-OSH1 module orchestrates secondary cell wall formation in rice.,2023,10.1016/j.celrep.2023.112702,https://pubmed.ncbi.nlm.nih.gov/37384532/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,40644666,JAGGED and DROOPING LEAF synergistically establish sexual organs and terminate floral meristem in rice.,2025,10.1111/tpj.70346,https://pubmed.ncbi.nlm.nih.gov/40644666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,35666814,Involvement of the linker histone H1Foo in the regulation of oogenesis.,2022,10.1530/rep-21-0233,https://pubmed.ncbi.nlm.nih.gov/35666814/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,34773305,"Rice RS2-9, which is bound by transcription factor OSH1, blocks enhancer-promoter interactions in plants.",2022,10.1111/tpj.15574,https://pubmed.ncbi.nlm.nih.gov/34773305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,34023782,Oocyte-specific linker histone H1foo interacts with Esrrb to induce chromatin decondensation at specific gene loci.,2021,10.1016/j.bbrc.2021.05.033,https://pubmed.ncbi.nlm.nih.gov/34023782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,39206939,"Adaxial-abaxial bipolar leaf genes encode a putative cytokinin receptor and HD-Zip III, and control the formation of ectopic shoot meristems in rice.",2024,10.1242/dev.202607,https://pubmed.ncbi.nlm.nih.gov/39206939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,35498659,OsbZIP47 Is an Integrator for Meristem Regulators During Rice Plant Growth and Development.,2022,10.3389/fpls.2022.865928,https://pubmed.ncbi.nlm.nih.gov/35498659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,38305492,STAMENLESS1 activates SUPERWOMAN 1 and FLORAL ORGAN NUMBER 1 to control floral organ identities and meristem fate in rice.,2024,10.1111/tpj.16637,https://pubmed.ncbi.nlm.nih.gov/38305492/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,31892265,Identification and Characterization of an OSH1 Thiol Reductase from Populus Trichocarpa.,2019,10.3390/cells9010076,https://pubmed.ncbi.nlm.nih.gov/31892265/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,31231579,Novel GFP-fused protein probes for detecting phosphatidylinositol-4-phosphate in the plasma membrane.,2019,10.1080/19768354.2019.1599424,https://pubmed.ncbi.nlm.nih.gov/31231579/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,37232925,Selection of a Novel DNA Aptamer Specific for 5-Hydroxymethylfurfural Using Capture-SELEX.,2023,10.3390/bios13050564,https://pubmed.ncbi.nlm.nih.gov/37232925/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,28847935,LATERAL FLORET 1 induced the three-florets spikelet in rice.,2017,10.1073/pnas.1700504114,https://pubmed.ncbi.nlm.nih.gov/28847935/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,31928972,pH Biosensing by PI4P Regulates Cargo Sorting at the TGN.,2020,10.1016/j.devcel.2019.12.010,https://pubmed.ncbi.nlm.nih.gov/31928972/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,33857182,Structure of human ORP3 ORD reveals conservation of a key function and ligand specificity in OSBP-related proteins.,2021,10.1371/journal.pone.0248781,https://pubmed.ncbi.nlm.nih.gov/33857182/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,26053026,Adverse Effects of High Concentrations of Fluoride on Characteristics of the Ovary and Mature Oocyte of Mouse.,2015,10.1371/journal.pone.0129594,https://pubmed.ncbi.nlm.nih.gov/26053026/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,23458164,Identifying candidate oocyte reprogramming factors using cross-species global transcriptional analysis.,2013,10.1089/cell.2012.0060,https://pubmed.ncbi.nlm.nih.gov/23458164/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,21689253,Osh proteins regulate membrane sterol organization but are not required for sterol movement between the ER and PM.,2011,10.1111/j.1600-0854.2011.01234.x,https://pubmed.ncbi.nlm.nih.gov/21689253/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,11238399,Overlapping functions of the yeast oxysterol-binding protein homologues.,2001,10.1093/genetics/157.3.1117,https://pubmed.ncbi.nlm.nih.gov/11238399/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,14990068,[Characteristics of immunoglobulin heavy chain variable region genes in childhood B-cell acute lymphoblastic leukemia].,2004,,https://pubmed.ncbi.nlm.nih.gov/14990068/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,9212308,Further evidence for a high incidence of nocturnal hypoglycaemia in IDDM: no effect of dose for dose transfer between human and porcine insulins.,1997,10.1002/(sici)1096-9136(199706)14:6<442::aid-did386>3.0.co;2-w,https://pubmed.ncbi.nlm.nih.gov/9212308/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,8854778,[The preventive effect of weekly high-dose 5-FU infusion (WHF) after resection of hepatic metastasis from colorectal cancer].,1996,,https://pubmed.ncbi.nlm.nih.gov/8854778/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H1-8,ENSG00000178804,Unsafe,12711322,Structure and expression of the human oocyte-specific histone H1 gene elucidated by direct RT-nested PCR of a single oocyte.,2003,10.1016/s0006-291x(03)00610-7,https://pubmed.ncbi.nlm.nih.gov/12711322/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AC1,ENSG00000164508,Unsafe,38355687,Potential Alzheimer's early biomarkers in a transgenic rat model and benefits of diazoxide/dibenzoylmethane co-treatment on spatial memory and AD-pathology.,2024,10.1038/s41598-024-54156-z,https://pubmed.ncbi.nlm.nih.gov/38355687/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AC1,ENSG00000164508,Unsafe,31534549,Prostaglandin E2 induces DNA hypermethylation in gastric cancer in vitro and in vivo.,2019,10.7150/thno.35766,https://pubmed.ncbi.nlm.nih.gov/31534549/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AC1,ENSG00000164508,Unsafe,27914986,Identification of epigenetically downregulated Tmem70 and Ube2e2 in rat liver after 28-day treatment with hepatocarcinogenic thioacetamide showing gene product downregulation in hepatocellular preneoplastic and neoplastic lesions produced by tumor promotion.,2017,10.1016/j.toxlet.2016.11.022,https://pubmed.ncbi.nlm.nih.gov/27914986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AC1,ENSG00000164508,Unsafe,26403067,Gene expression profile of necrotizing enterocolitis model in neonatal mice.,2015,10.1016/j.ijsu.2015.09.049,https://pubmed.ncbi.nlm.nih.gov/26403067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2AC1,ENSG00000164508,Unsafe,16098230,Comparative analysis of expression of histone H2a genes in mouse.,2005,10.1186/1471-2164-6-108,https://pubmed.ncbi.nlm.nih.gov/16098230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC12L,ENSG00000234289,Unsafe,39680331,METTL3-Mediated m6A Methylation of USP21 Contributes to Hepatocellular Carcinoma Progression by Stabilizing H2BFS Through Deubiquitination.,2025,10.1007/s10528-024-10992-2,https://pubmed.ncbi.nlm.nih.gov/39680331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC12L,ENSG00000234289,Unsafe,33044785,Poly(ADP-ribose) glycohydrolase silencing-mediated H2B expression inhibits benzo(a)pyrene-induced carcinogenesis.,2021,10.1002/tox.23034,https://pubmed.ncbi.nlm.nih.gov/33044785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC12L,ENSG00000234289,Unsafe,36371414,Identification of novel interferon responsive protein partners of human leukocyte antigen A (HLA-A) using cross-linking mass spectrometry (CLMS) approach.,2022,10.1038/s41598-022-21393-z,https://pubmed.ncbi.nlm.nih.gov/36371414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC12L,ENSG00000234289,Unsafe,22622828,Possible novel roles of poly(rC)-binding protein 1 in SH-SY5Y neurocytes: an analysis using a dynamic Bayesian network.,2012,10.1007/s12264-012-1242-6,https://pubmed.ncbi.nlm.nih.gov/22622828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC3,ENSG00000276410,Unsafe,41416491,Blood gene expression network expression strongly relates to brain amyloid burden.,2025,10.1002/alz.70982,https://pubmed.ncbi.nlm.nih.gov/41416491/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC3,ENSG00000276410,Unsafe,41327695,Analysis of key genes and pathways of knee osteoarthritis based on GEO data mining.,2025,10.1097/md.0000000000046250,https://pubmed.ncbi.nlm.nih.gov/41327695/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC3,ENSG00000276410,Unsafe,39907412,Microbial signatures in head and neck squamous cell carcinoma: an in silico study.,2025,10.1590/1678-7757-2024-0392,https://pubmed.ncbi.nlm.nih.gov/39907412/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC3,ENSG00000276410,Unsafe,39295860,Integrated transcriptomic analysis and machine learning for characterizing diagnostic biomarkers and immune cell infiltration in fetal growth restriction.,2024,10.3389/fimmu.2024.1381795,https://pubmed.ncbi.nlm.nih.gov/39295860/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC3,ENSG00000276410,Unsafe,36845147,DKK3's protective role in prostate cancer is partly due to the modulation of immune-related pathways.,2023,10.3389/fimmu.2023.978236,https://pubmed.ncbi.nlm.nih.gov/36845147/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC3,ENSG00000276410,Unsafe,32581010,HIST1H2BB and MAGI2 Methylation and Somatic Mutations as Precision Medicine Biomarkers for Diagnosis and Prognosis of High-grade Serous Ovarian Cancer.,2020,10.1158/1940-6207.capr-19-0412,https://pubmed.ncbi.nlm.nih.gov/32581010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC3,ENSG00000276410,Unsafe,35356930,Investigation of hub genes involved in Turner syndrome using biological informatics methods.,2022,10.1097/md.0000000000029069,https://pubmed.ncbi.nlm.nih.gov/35356930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC3,ENSG00000276410,Unsafe,36407085,"Downregulation of hsa-miR-135b-5p Inhibits Cell Proliferation, Migration, and Invasion in Colon Adenocarcinoma.",2022,10.1155/2022/2907554,https://pubmed.ncbi.nlm.nih.gov/36407085/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC3,ENSG00000276410,Unsafe,32235312,Frequent FOXA1-Activating Mutations in Extramammary Paget's Disease.,2020,10.3390/cancers12040820,https://pubmed.ncbi.nlm.nih.gov/32235312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC3,ENSG00000276410,Unsafe,33044785,Poly(ADP-ribose) glycohydrolase silencing-mediated H2B expression inhibits benzo(a)pyrene-induced carcinogenesis.,2021,10.1002/tox.23034,https://pubmed.ncbi.nlm.nih.gov/33044785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC3,ENSG00000276410,Unsafe,31075877,Bioinformatic Analysis of Gene Variants from Gastroschisis Recurrence Identifies Multiple Novel Pathogenetic Pathways: Implication for the Closure of the Ventral Body Wall.,2019,10.3390/ijms20092295,https://pubmed.ncbi.nlm.nih.gov/31075877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC3,ENSG00000276410,Unsafe,29470511,"Preliminary analysis of proteome alterations in non-aneurysmal, internal mammary artery tissue from patients with abdominal aortic aneurysms.",2018,10.1371/journal.pone.0192957,https://pubmed.ncbi.nlm.nih.gov/29470511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC3,ENSG00000276410,Unsafe,28484590,Histone 3.3 hotspot mutations in conventional osteosarcomas: a comprehensive clinical and molecular characterization of six H3F3A mutated cases.,2017,10.1186/s13569-017-0075-5,https://pubmed.ncbi.nlm.nih.gov/28484590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC3,ENSG00000276410,Unsafe,30713489,Identification of Altered Developmental Pathways in Human Juvenile HD iPSC With 71Q and 109Q Using Transcriptome Profiling.,2018,10.3389/fncel.2018.00528,https://pubmed.ncbi.nlm.nih.gov/30713489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H2BC3,ENSG00000276410,Unsafe,29608426,Identification of Hub Genes and Pathways in Zika Virus Infection Using RNA-Seq Data: A Network-Based Computational Approach.,2018,10.1089/vim.2017.0116,https://pubmed.ncbi.nlm.nih.gov/29608426/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,42248887,The eutherian-specific histone H3.4 promotes germ cell development and reproductive fitness.,2026,10.1038/s41467-026-73954-9,https://pubmed.ncbi.nlm.nih.gov/42248887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,40241305,Coupling deep phenotypic quantification with next-generation phenotyping for 192 individuals with germline histonopathies.,2025,10.1016/j.xhgg.2025.100440,https://pubmed.ncbi.nlm.nih.gov/40241305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,41133746,Genomic Drivers of Pyrethroid Resistance Escalation in the Malaria Vector Anopheles funestus Across Africa.,2025,10.1093/molbev/msaf251,https://pubmed.ncbi.nlm.nih.gov/41133746/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,33523913,B7-H3×4-1BB bispecific antibody augments antitumor immunity by enhancing terminally differentiated CD8+ tumor-infiltrating lymphocytes.,2021,10.1126/sciadv.aax3160,https://pubmed.ncbi.nlm.nih.gov/33523913/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,39405936,Single-cell sequencing reveals the heterogeneity of immune landscape in drug users with HIV infection.,2024,10.1016/j.intimp.2024.113338,https://pubmed.ncbi.nlm.nih.gov/39405936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,36305094,"Distinct clinicopathological characteristics, genomic alteration and prognosis in breast cancer with concurrent TP53 mutation and MYC amplification.",2022,10.1111/1759-7714.14703,https://pubmed.ncbi.nlm.nih.gov/36305094/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,40485922,"Biomechanics of elite handcyclists are highly individual-a case series on kinetics, kinematics, and muscular activity.",2025,10.3389/fspor.2025.1581301,https://pubmed.ncbi.nlm.nih.gov/40485922/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,38795259,Unravelling the molecular mechanistic pathway underlying the anticancer effects of kaempferol in colorectal cancer: a reverse pharmacology network approach.,2025,10.1007/s11030-024-10890-0,https://pubmed.ncbi.nlm.nih.gov/38795259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,36553353,"Study on Nutritional Knowledge, Attitude and Behavior of Chinese School Football Players.",2022,10.3390/children9121910,https://pubmed.ncbi.nlm.nih.gov/36553353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,39511294,"Evaluating the antidiabetes and antioxidant activities of halogenated Schiff bases derived from 4-(diethylamino)salicylaldehyde: in vitro antidiabetes, antioxidant and computational investigation.",2024,10.1038/s41598-024-78460-w,https://pubmed.ncbi.nlm.nih.gov/39511294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,32006051,Clinical application of immune checkpoints in targeted immunotherapy of prostate cancer.,2020,10.1007/s00018-020-03459-1,https://pubmed.ncbi.nlm.nih.gov/32006051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,25445010,Pathway analysis for a genome-wide association study of pneumoconiosis.,2015,10.1016/j.toxlet.2014.10.028,https://pubmed.ncbi.nlm.nih.gov/25445010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,32810596,Plasma fibrin clot proteomics in patients with acute pulmonary embolism: Association with clot properties.,2020,10.1016/j.jprot.2020.103946,https://pubmed.ncbi.nlm.nih.gov/32810596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,30223148,"New azafluorenones with cytotoxic and carbonic anhydrase inhibitory properties: 2-Aryl-4-(4-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-5-ones.",2018,10.1016/j.bioorg.2018.09.013,https://pubmed.ncbi.nlm.nih.gov/30223148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,26073357,The effects of various mixing solutions on the biocompatibility of mineral trioxide aggregate.,2016,10.1111/iej.12483,https://pubmed.ncbi.nlm.nih.gov/26073357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,27926813,Perturbation of H3K27me3-Associated Epigenetic Processes Increases Agrobacterium-Mediated Transformation.,2017,10.1094/mpmi-12-16-0250-r,https://pubmed.ncbi.nlm.nih.gov/27926813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,19038236,Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.,2009,10.1016/j.cbi.2008.10.051,https://pubmed.ncbi.nlm.nih.gov/19038236/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,21705643,Transcription factor-dependent chromatin remodeling at heat shock and copper-responsive promoters in Chlamydomonas reinhardtii.,2011,10.1105/tpc.111.085266,https://pubmed.ncbi.nlm.nih.gov/21705643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,29494324,Correlation of Radiation Dose Estimates by DIC with the METREPOL Hematological Classes of Disease Severity.,2018,10.1667/rr14936.1,https://pubmed.ncbi.nlm.nih.gov/29494324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,24316866,Histamine induces chemotaxis and phagocytosis in murine bone marrow-derived macrophages and RAW 264.7 macrophage-like cells via histamine H4-receptor.,2014,10.1007/s00011-013-0694-0,https://pubmed.ncbi.nlm.nih.gov/24316866/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,19789320,A phase I dose-finding study of 5-azacytidine in combination with sodium phenylbutyrate in patients with refractory solid tumors.,2009,10.1158/1078-0432.ccr-09-0567,https://pubmed.ncbi.nlm.nih.gov/19789320/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,12719580,Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120.,2003,10.1128/jvi.77.10.5863-5876.2003,https://pubmed.ncbi.nlm.nih.gov/12719580/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3-4,ENSG00000168148,Unsafe,17805310,Altered memory capacities and response to stress in p300/CBP-associated factor (PCAF) histone acetylase knockout mice.,2008,10.1038/sj.npp.1301551,https://pubmed.ncbi.nlm.nih.gov/17805310/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,42734902,Cell Type-Resolved Causal Inference and Spatial Transcriptomic Integration Reveal Immune-Specific Genetic Drivers of Autoimmune and Malignant Thyroid Disease.,2026,10.1111/iji.70066,https://pubmed.ncbi.nlm.nih.gov/42734902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,42166442,Molecular and structural reprogramming of gastric cancer revealed by systems-level transcriptomic analysis.,2026,10.1371/journal.pone.0344143,https://pubmed.ncbi.nlm.nih.gov/42166442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,40241895,Plasma methylated &lt;i&gt;HIST1H3G&lt;/i&gt; as a non-invasive biomarker for diagnostic modeling of hepatocellular carcinoma.,2025,10.3389/fmed.2025.1571737,https://pubmed.ncbi.nlm.nih.gov/40241895/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,42272657,Case Report: Cutaneous niche-restricted malignant phenotypes in PTCL-NOS revealed by single-cell sequencing.,2026,10.3389/fonc.2026.1827539,https://pubmed.ncbi.nlm.nih.gov/42272657/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,41420251,Novel DNA methylation biomarkers in urine for non-invasive diagnosis of bladder urothelial carcinoma.,2025,10.1186/s13148-025-01964-3,https://pubmed.ncbi.nlm.nih.gov/41420251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,39258138,Gene Expression Levels Related to Histone Acetylation are Altered in Parkinson Disease Patients.,2024,10.29399/npa.28700,https://pubmed.ncbi.nlm.nih.gov/39258138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,42219787,Computational Analysis of Differentially Expressed Genes in Arsenic-Induced Carcinogenesis and Their Effect on Human Repair Mechanisms.,2026,10.1002/em.70060,https://pubmed.ncbi.nlm.nih.gov/42219787/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,41628438,Primary subdural tumor mimicking subdural hematoma: illustrative case.,2026,10.3171/case25849,https://pubmed.ncbi.nlm.nih.gov/41628438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,40406416,Genetic mechanisms of hemispheric functional connectivity in diabetic retinopathy: a joint neuroimaging and transcriptomic study.,2025,10.3389/fcell.2025.1590627,https://pubmed.ncbi.nlm.nih.gov/40406416/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,42911469,CLU attenuates sepsis-associated acute lung injury by inhibiting Bax-mediated mitochondrial damage.,2026,10.1007/s11033-026-12794-8,https://pubmed.ncbi.nlm.nih.gov/42911469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,40841384,Genomic analysis identifies TJP3 as a prognostic marker for radiotherapy and chemoradiotherapy in oral squamous cell carcinoma.,2025,10.1038/s41598-025-05025-w,https://pubmed.ncbi.nlm.nih.gov/40841384/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,39095857,Analysis of miR-497/195 cluster identifies new therapeutic targets in cervical cancer.,2024,10.1186/s13104-024-06876-8,https://pubmed.ncbi.nlm.nih.gov/39095857/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,34257654,Network Pharmacology and Bioinformatics Methods Reveal the Mechanism of Zao-Jiao-Ci in the Treatment of LSCC.,2021,10.1155/2021/8862821,https://pubmed.ncbi.nlm.nih.gov/34257654/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,42177073,Transcriptomic insights into epigenetic and immunomodulatory roles of nuclear histone genes in bladder cancer: A bioinformatics approach.,2026,10.1016/bs.apcsb.2026.01.002,https://pubmed.ncbi.nlm.nih.gov/42177073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,37818718,H3K27M mutant glioma: Disease definition and biological underpinnings.,2024,10.1093/neuonc/noad164,https://pubmed.ncbi.nlm.nih.gov/37818718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,40566633,Transcriptomic and miRNA Signatures of ChAdOx1 nCoV-19 Vaccine Response Using Machine Learning.,2025,10.3390/life15060981,https://pubmed.ncbi.nlm.nih.gov/40566633/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,40213693,Celastrol reduces cisplatin-induced nephrotoxicity by downregulating SNORD3A level in kidney organoids derived from human iPSCs.,2025,10.3389/fphar.2025.1464525,https://pubmed.ncbi.nlm.nih.gov/40213693/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,38728468,NR1I2 as a core biological target in chronic venous ulcer tissues treated with ultrasound therapy.,2024,10.1097/md.0000000000038092,https://pubmed.ncbi.nlm.nih.gov/38728468/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,39138148,Chromatin remodeling-driven autophagy activation induces cisplatin resistance in oral squamous cell carcinoma.,2024,10.1038/s41419-024-06975-1,https://pubmed.ncbi.nlm.nih.gov/39138148/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,39456545,"H3K27me3 Loss in Central Nervous System Tumors: Diagnostic, Prognostic, and Therapeutic Implications.",2024,10.3390/cancers16203451,https://pubmed.ncbi.nlm.nih.gov/39456545/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,37152806,Pediatric diffuse midline glioma: Understanding the mechanisms and assessing the next generation of personalized therapeutics.,2023,10.1093/noajnl/vdad040,https://pubmed.ncbi.nlm.nih.gov/37152806/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,38997544,Prioritizing drug targets in systemic lupus erythematosus from a genetic perspective: a druggable genome-wide Mendelian randomization study.,2024,10.1007/s10067-024-07059-3,https://pubmed.ncbi.nlm.nih.gov/38997544/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,36313990,Synthetic antibody-derived immunopeptide provides neuroprotection in glaucoma through molecular interaction with retinal protein histone H3.1.,2022,10.3389/fmed.2022.993351,https://pubmed.ncbi.nlm.nih.gov/36313990/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,40206344,Integrating single-cell sequencing and clinical insights to explore malignant transformation in odontogenic keratocyst.,2025,10.1016/j.csbj.2025.03.027,https://pubmed.ncbi.nlm.nih.gov/40206344/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,39054369,Combined inhibition of EZH2 and CDK4/6 perturbs endoplasmic reticulum-mitochondrial homeostasis and increases antitumor activity against glioblastoma.,2024,10.1038/s41698-024-00653-3,https://pubmed.ncbi.nlm.nih.gov/39054369/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,33086884,Fucoxanthin may inhibit cervical cancer cell proliferation via downregulation of HIST1H3D.,2020,10.1177/0300060520964011,https://pubmed.ncbi.nlm.nih.gov/33086884/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,40589756,Transcriptomic and proteomic signatures of host NK cells delineate distinct immune states across tuberculosis infection statuses.,2025,10.3389/fimmu.2025.1607770,https://pubmed.ncbi.nlm.nih.gov/40589756/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,38831441,Single-cell and genome-wide Mendelian randomization identifies causative genes for gout.,2024,10.1186/s13075-024-03348-z,https://pubmed.ncbi.nlm.nih.gov/38831441/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,34759345,Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies.,2022,10.1038/s41388-021-02102-y,https://pubmed.ncbi.nlm.nih.gov/34759345/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,33732456,Genetic signature and treatment of pediatric high-grade glioma.,2021,10.3892/mco.2021.2232,https://pubmed.ncbi.nlm.nih.gov/33732456/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H3C12,ENSG00000197153,Unsafe,33807733,Advanced Pediatric Diffuse Pontine Glioma Murine Models Pave the Way towards Precision Medicine.,2021,10.3390/cancers13051114,https://pubmed.ncbi.nlm.nih.gov/33807733/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,42807222,HIST1H4L promotes small cell lung cancer tumorigenesis by regulating the PI3K/Akt pathway and serves as a potential diagnostic biomarker.,2026,10.3389/fonc.2026.1959848,https://pubmed.ncbi.nlm.nih.gov/42807222/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,42177073,Transcriptomic insights into epigenetic and immunomodulatory roles of nuclear histone genes in bladder cancer: A bioinformatics approach.,2026,10.1016/bs.apcsb.2026.01.002,https://pubmed.ncbi.nlm.nih.gov/42177073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,41620483,Evaluating the prognostic significance of HIST1H4C in breast cancer: implications for neoadjuvant therapy.,2026,10.1038/s41598-026-36983-4,https://pubmed.ncbi.nlm.nih.gov/41620483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,41204370,Identification of potential blood biomarkers of coronary artery disease using a cuproptosis gene set.,2025,10.1186/s40001-025-03276-x,https://pubmed.ncbi.nlm.nih.gov/41204370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,42138757,Identification of oxidative stress-related hub genes and immune infiltration characterization in chronic spontaneous urticaria.,2026,10.1007/s00438-026-02441-z,https://pubmed.ncbi.nlm.nih.gov/42138757/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,41805714,Systems biology analysis uncovers a ROS-associated gene signature and immunomodulatory role of CLEC4E in ischemic stroke.,2026,10.1371/journal.pone.0344443,https://pubmed.ncbi.nlm.nih.gov/41805714/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,40618071,Nasopharyngeal carcinoma detected noninvasively in the real world using three gene methylation analyses from automatically processed bilateral nasal swab samples.,2025,10.1186/s12885-025-14508-y,https://pubmed.ncbi.nlm.nih.gov/40618071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,37291167,Bioinformatics and system biology approach to identify potential common pathogenesis for COVID-19 infection and osteoarthritis.,2023,10.1038/s41598-023-32555-y,https://pubmed.ncbi.nlm.nih.gov/37291167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,32196466,Network-based computational approach to identify genetic links between cardiomyopathy and its risk factors.,2020,10.1049/iet-syb.2019.0074,https://pubmed.ncbi.nlm.nih.gov/32196466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,41317394,Genome-Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes.,2026,10.1002/advs.202500852,https://pubmed.ncbi.nlm.nih.gov/41317394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,38115290,"SEPT9, H4C6, and RASSF1A methylation in nasopharyngeal swabs: A reflection of potential minimally invasive biomarkers for early screening of nasopharyngeal cancer.",2023,10.1097/md.0000000000036583,https://pubmed.ncbi.nlm.nih.gov/38115290/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,41094424,Integrating urinary dual-gene methylation and VI-RADS score to predict residual tumors after TURBT in NMIBC: a nomogram-based model.,2025,10.1186/s12894-025-01857-w,https://pubmed.ncbi.nlm.nih.gov/41094424/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,40406416,Genetic mechanisms of hemispheric functional connectivity in diabetic retinopathy: a joint neuroimaging and transcriptomic study.,2025,10.3389/fcell.2025.1590627,https://pubmed.ncbi.nlm.nih.gov/40406416/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,41257806,Metabolomic biomarkers of psychotic conversion in ultra-high-risk subjects: a pilot study.,2025,10.1038/s41398-025-03679-8,https://pubmed.ncbi.nlm.nih.gov/41257806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,40011626,Analysis the diagnostic performance of H4C6/SOX1-OT gene methylation in bladder cancer based on urine sample.,2025,10.1038/s41598-025-91337-w,https://pubmed.ncbi.nlm.nih.gov/40011626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,40847031,A prediction model based on cfDNA concentration and cfDNA methylation biomarkers for lung cancer detection.,2025,10.1038/s41598-025-15273-5,https://pubmed.ncbi.nlm.nih.gov/40847031/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,42803887,Palmitoleic acid n7 improves glucose uptake and metabolism and attenuates oxidative stress in human visceral adipocytes.,2026,10.1007/s12020-026-04766-6,https://pubmed.ncbi.nlm.nih.gov/42803887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,38584417,Endometrial Cancer Detection by DNA Methylation Analysis in Cervical Papanicolaou Brush Samples.,2024,10.1177/15330338241242637,https://pubmed.ncbi.nlm.nih.gov/38584417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,35868868,"Bioinformatics analysis of microarray data to identify hub genes, as diagnostic biomarker of HELLP syndrome: System biology approach.",2022,10.1111/jog.15363,https://pubmed.ncbi.nlm.nih.gov/35868868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,35922383,Transcriptome and genome sequencing investigating the molecular characteristics of patients with varicocele infertility.,2022,10.1111/and.14542,https://pubmed.ncbi.nlm.nih.gov/35922383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,42908912,Antibody-drug conjugates in advanced small-cell lung cancer: a systematic review and single-arm meta-analysis of later-line monotherapy.,2026,10.3389/fimmu.2026.1929911,https://pubmed.ncbi.nlm.nih.gov/42908912/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,42767768,"Phase 1 study of KHK2455, a long-acting, potent and selective IDO1 inhibitor, in combination with avelumab in patients with locally advanced or metastatic urothelial carcinoma.",2026,10.1136/jitc-2026-015178,https://pubmed.ncbi.nlm.nih.gov/42767768/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,42577949,"Nivolumab + Doxorubicin, Vinblastine, and Dacarbazine in HIV-Associated Advanced-Stage Classic Hodgkin Lymphoma.",2026,10.1200/oa-25-00143,https://pubmed.ncbi.nlm.nih.gov/42577949/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,40180420,Phase I study on neoadjuvant combination immunotherapy with mogamulizumab and nivolumab for solid tumors.,2025,10.1136/jitc-2024-010634,https://pubmed.ncbi.nlm.nih.gov/40180420/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,42575113,8-year vaccine protection following a single dose of Vi-tetanus toxoid conjugate vaccine in children in Nepal (TyVOID): a prospective cohort follow-up study of the TyVAC Nepal randomised controlled trial.,2026,10.1016/j.langlo.2026.104009,https://pubmed.ncbi.nlm.nih.gov/42575113/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,41229044,Exploring genetic linkage between rheumatoid arthritis and systemic lupus erythematosus through biological networks and prioritizing omega-3 fatty acids as a potent therapeutic.,2025,10.15586/aei.v53i6.1492,https://pubmed.ncbi.nlm.nih.gov/41229044/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,40540446,Efficacy and safety of immunotherapy-based neoadjuvant regimens in locally advanced gastric cancer: a meta-analysis based on high-quality clinical trials.,2025,10.1097/js9.0000000000002815,https://pubmed.ncbi.nlm.nih.gov/40540446/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,41136986,Characterizing immune profiles in hepatocellular carcinoma patients benefiting from pembrolizumab and lenvatinib using machine learning.,2025,10.1186/s12885-025-14945-9,https://pubmed.ncbi.nlm.nih.gov/41136986/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,40273550,"A phase I clinical trial of radiation therapy, durvalumab and tremelimumab in recurrent gynecologic cancer.",2025,10.1016/j.ygyno.2025.04.006,https://pubmed.ncbi.nlm.nih.gov/40273550/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,42731887,Integrated metabolomics and DNA methylation signatures and their association with flare remission in SLE.,2026,10.1136/lupus-2026-002017,https://pubmed.ncbi.nlm.nih.gov/42731887/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,42555603,"Feasibility, safety and tolerability of intradialytic creatine supplementation in hemodialysis: A double-blind, randomized, placebo-controlled pilot study.",2026,10.1371/journal.pone.0354883,https://pubmed.ncbi.nlm.nih.gov/42555603/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,42364736,Clinical outcomes of myeloablative allogeneic peripheral blood stem cell transplantation for relapsed/refractory T-ALL/LBL: A single-center study.,2026,10.1016/j.trim.2026.102413,https://pubmed.ncbi.nlm.nih.gov/42364736/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,40104740,Genome-wide profiling of a prognostic RNA-binding protein signature in esophageal cancer.,2025,10.21037/tcr-2024-2561,https://pubmed.ncbi.nlm.nih.gov/40104740/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,42410427,Evidence-based nursing practice for the removal of peripheral arterial catheters in adult patients.,2026,10.1186/s12912-026-04999-w,https://pubmed.ncbi.nlm.nih.gov/42410427/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,41285561,Intermittent hypoxia and caffeine in infants born preterm: the ICAF Randomized Clinical Trial.,2026,10.1136/archdischild-2025-329230,https://pubmed.ncbi.nlm.nih.gov/41285561/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,42465842,Predictors for identifying autoimmune encephalitis in pediatric patients.,2026,10.3389/fcimb.2026.1827367,https://pubmed.ncbi.nlm.nih.gov/42465842/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,41704941,Interventions to improve pneumococcal vaccination coverage: A systematic review and meta-analysis.,2026,10.1016/j.imj.2026.100238,https://pubmed.ncbi.nlm.nih.gov/41704941/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
H4C6,ENSG00000274618,Unsafe,41630865,"Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 (TYK2) inhibitor, in patients with moderate to severe scalp psoriasis: Efficacy and safety results through week 16 in a phase 3b/4, multicenter, randomized, double-blinded, placebo-controlled trial (PSORIATYK SCALP).",2026,10.1016/j.jdin.2025.09.022,https://pubmed.ncbi.nlm.nih.gov/41630865/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HARBI1,ENSG00000180423,Unsafe,41769318,Duplication of the prothrombin gene is associated with a significant increase in thrombin generation.,2026,10.1016/j.rpth.2026.103386,https://pubmed.ncbi.nlm.nih.gov/41769318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HARBI1,ENSG00000180423,Unsafe,41077360,Identification of PcHARBI1-5 in Pugionium cornutum reveals its negative involvement in tolerance to divergent abiotic stresses.,2025,10.1016/j.gene.2025.149821,https://pubmed.ncbi.nlm.nih.gov/41077360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HARBI1,ENSG00000180423,Unsafe,39902812,OsHARBI1-1 enhances cadmium tolerance in yeast through YAP1 mediated modulation of cell wall integrity genes and catalase genes.,2025,10.1096/fj.202400111r,https://pubmed.ncbi.nlm.nih.gov/39902812/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HARBI1,ENSG00000180423,Unsafe,35665839,Discovery and functional characterization of novel cotton promoters with potential application to pest control.,2022,10.1007/s00299-022-02880-z,https://pubmed.ncbi.nlm.nih.gov/35665839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HARBI1,ENSG00000180423,Unsafe,33775357,"MdHARBI1, a MdATG8i-interacting protein, plays a positive role in plant thermotolerance.",2021,10.1016/j.plantsci.2021.110850,https://pubmed.ncbi.nlm.nih.gov/33775357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HARBI1,ENSG00000180423,Unsafe,29680489,Molecular characterization of shrimp harbinger transposase derived 1 (HARBI1)-like and its role in white spot syndrome virus and Vibrio alginolyticus infection.,2018,10.1016/j.fsi.2018.04.032,https://pubmed.ncbi.nlm.nih.gov/29680489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HARBI1,ENSG00000180423,Unsafe,31216437,Differentially expressed genes of the shrimp Marsupenaeus japonicus in response to infection by white spot syndrome virus or Vibrio alginolyticus.,2019,10.1016/j.fsi.2019.06.034,https://pubmed.ncbi.nlm.nih.gov/31216437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HARBI1,ENSG00000180423,Unsafe,15169610,Harbinger transposons and an ancient HARBI1 gene derived from a transposase.,2004,10.1089/104454904323090949,https://pubmed.ncbi.nlm.nih.gov/15169610/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HARBI1,ENSG00000180423,Unsafe,18339812,Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes.,2008,10.1073/pnas.0707746105,https://pubmed.ncbi.nlm.nih.gov/18339812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HARBI1,ENSG00000180423,Unsafe,22045999,A living fossil in the genome of a living fossil: Harbinger transposons in the coelacanth genome.,2012,10.1093/molbev/msr267,https://pubmed.ncbi.nlm.nih.gov/22045999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,40846850,Conserved function of the HAUS6 calponin homology domain in anchoring augmin for microtubule branching.,2025,10.1038/s41467-025-63165-z,https://pubmed.ncbi.nlm.nih.gov/40846850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,41286847,HAUS6 as a potential prognostic and immunological biomarker: validation from pan-cancer analysis to hepatocellular carcinoma.,2025,10.1186/s12935-025-04081-6,https://pubmed.ncbi.nlm.nih.gov/41286847/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,41173848,How augmin establishes the angle of the microtubule branch site.,2025,10.1038/s41467-025-64650-1,https://pubmed.ncbi.nlm.nih.gov/41173848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,38759391,Bioinformatics analysis and validation of HAUS6 as a key prognostic gene in squamous cell carcinoma of the tongue.,2024,10.1016/j.archoralbio.2024.106000,https://pubmed.ncbi.nlm.nih.gov/38759391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,35883570,Genetic Control of Kinetochore-Driven Microtubule Growth in Drosophila Mitosis.,2022,10.3390/cells11142127,https://pubmed.ncbi.nlm.nih.gov/35883570/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,35096810,Down-Regulating HAUS6 Suppresses Cell Proliferation by Activating the p53/p21 Pathway in Colorectal Cancer.,2021,10.3389/fcell.2021.772077,https://pubmed.ncbi.nlm.nih.gov/35096810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,37161065,A prognostic model based on the Augmin family genes for LGG patients.,2023,10.1038/s41598-023-34779-4,https://pubmed.ncbi.nlm.nih.gov/37161065/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,34427181,Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development.,2021,10.7554/elife.67989,https://pubmed.ncbi.nlm.nih.gov/34427181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,37540242,Transcriptome-wide association study-derived genes as potential visceral adipose tissue-specific targets for type 2 diabetes.,2023,10.1007/s00125-023-05978-5,https://pubmed.ncbi.nlm.nih.gov/37540242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,29514856,Mitotic spindle assembly and γ-tubulin localisation depend on the integral nuclear membrane protein Samp1.,2018,10.1242/jcs.211664,https://pubmed.ncbi.nlm.nih.gov/29514856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,31043753,A transcriptome-wide association study of high-grade serous epithelial ovarian cancer identifies new susceptibility genes and splice variants.,2019,10.1038/s41588-019-0395-x,https://pubmed.ncbi.nlm.nih.gov/31043753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,35054443,B Chromosomes' Sequences in Yellow-Necked Mice Apodemus flavicollis-Exploring the Transcription.,2021,10.3390/life12010050,https://pubmed.ncbi.nlm.nih.gov/35054443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,36324506,Identification of genes modified by N6-methyladenosine in patients with colorectal cancer recurrence.,2022,10.3389/fgene.2022.1043297,https://pubmed.ncbi.nlm.nih.gov/36324506/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,33290408,A powerful method for pleiotropic analysis under composite null hypothesis identifies novel shared loci between Type 2 Diabetes and Prostate Cancer.,2020,10.1371/journal.pgen.1009218,https://pubmed.ncbi.nlm.nih.gov/33290408/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,32526247,mRNA and microRNA selection for breast cancer molecular subtype stratification using meta-heuristic based algorithms.,2020,10.1016/j.ygeno.2020.06.014,https://pubmed.ncbi.nlm.nih.gov/32526247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,19596795,"FAM29A, a target of Plk1 regulation, controls the partitioning of NEDD1 between the mitotic spindle and the centrosomes.",2009,10.1242/jcs.048223,https://pubmed.ncbi.nlm.nih.gov/19596795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,28351835,Cross-linking mass spectrometry identifies new interfaces of Augmin required to localise the γ-tubulin ring complex to the mitotic spindle.,2017,10.1242/bio.022905,https://pubmed.ncbi.nlm.nih.gov/28351835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,19029337,FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle.,2008,10.1083/jcb.200807046,https://pubmed.ncbi.nlm.nih.gov/19029337/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,19641730,Microtubule amplification in the assembly of mitotic spindle and the maturation of kinetochore fibers.,2009,10.4161/cib.2.3.7875,https://pubmed.ncbi.nlm.nih.gov/19641730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HAUS6,ENSG00000147874,Unsafe,22239941,A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians.,2012,10.1186/1471-2350-13-5,https://pubmed.ncbi.nlm.nih.gov/22239941/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,42116066,A new 308 A-G substitution in HBG2 in an acyanotic newborn: case report.,2026,10.1186/s13052-026-02275-w,https://pubmed.ncbi.nlm.nih.gov/42116066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,42740835,Evolution of the α-Glucosidase Gene Family in Apoidea.,2026,10.1002/ece3.74342,https://pubmed.ncbi.nlm.nih.gov/42740835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,42443740,"Molecular Epidemiology of δβ-Thalassemia and Hereditary Persistence of Fetal Hemoglobin (HPFH) in the Quanzhou Childbearing-Age Population, China.",2026,10.1080/03630269.2026.2692950,https://pubmed.ncbi.nlm.nih.gov/42443740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,42341077,Direct and indirect regulation of fetal globin transcript by the RNA-binding protein IGF2BP1.,2026,10.1182/blood.2025031840,https://pubmed.ncbi.nlm.nih.gov/42341077/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,41697720,Placental iron utilisation in fetal growth restriction: alterations in mitochondrial haem synthesis and iron-sulphur cluster assembly pathways.,2026,10.1113/jp289451,https://pubmed.ncbi.nlm.nih.gov/41697720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,41413825,Novel LRF/ZBTB7A variants and known HbF-modulating SNPs in transfusion-dependent β-thalassemia.,2025,10.1186/s12920-025-02275-5,https://pubmed.ncbi.nlm.nih.gov/41413825/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,42509210,Genetic Analysis of Two Patients with Compound Thalassemia Presenting with Elevated HbF and Normal HbA&lt;sub&gt;2&lt;/sub&gt; Levels.,2026,10.1080/03630269.2026.2703233,https://pubmed.ncbi.nlm.nih.gov/42509210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,42657270,Global genetic modifiers of fetal hemoglobin in sickle cell disease: Systematic review and meta-analysis.,2026,10.1016/j.isci.2026.116997,https://pubmed.ncbi.nlm.nih.gov/42657270/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,40278921,Decoding HbF reactivation by hydroxyurea in hemoglobinopathy patients through microRNA signatures.,2025,10.1007/s00277-025-06252-x,https://pubmed.ncbi.nlm.nih.gov/40278921/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,40613211,"Genetic Modifiers of HbF in HbAA and HbAS Women From São Tomé e Príncipe: An Association Study of Common Genetic Variants in &lt;i&gt;BCL11A&lt;/i&gt;, &lt;i&gt;MYB&lt;/i&gt;, &lt;i&gt;HBG2&lt;/i&gt;, and &lt;i&gt;BGLT3&lt;/i&gt;.",2025,10.31083/fbs38388,https://pubmed.ncbi.nlm.nih.gov/40613211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,41070331,Genetic Profiling and frequencies of Modifiers in Transfusion-Dependent Thalassemia.,2025,10.12669/pjms.41.9.11571,https://pubmed.ncbi.nlm.nih.gov/41070331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,42755327,CRISPR-Based Mediated Reactivation of Fetal Hemoglobin as a Therapeutic Strategy for Hemoglobinopathies: Evidence from Preclinical to Clinical Trials in Sickle Cell Disease and β-Thalassemia.,2026,10.1080/03630269.2026.2729189,https://pubmed.ncbi.nlm.nih.gov/42755327/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,40156013,A one-base therapeutic insertion in the HBG2 distal promoter reactivates γ-globin expression.,2025,10.1186/s40164-025-00626-7,https://pubmed.ncbi.nlm.nih.gov/40156013/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,41931048,CRISPR-Cas12a Gene Editing of &lt;i&gt;HBG1&lt;/i&gt; and &lt;i&gt;HBG2&lt;/i&gt; Promoters to Treat β-Thalassemia.,2026,10.1056/nejmoa2501277,https://pubmed.ncbi.nlm.nih.gov/41931048/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,41113105,G2B: an optimized lentiviral vector with enhanced titer and β-globin expression for improved β-thalassemia gene therapy.,2025,10.1097/bs9.0000000000000253,https://pubmed.ncbi.nlm.nih.gov/41113105/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,40963580,Machine learning-based integration develops an immune-derived signature for diagnosing high-altitude pulmonary hypertension.,2025,10.3389/fmed.2025.1603140,https://pubmed.ncbi.nlm.nih.gov/40963580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,41931046,Base Editing of &lt;i&gt;HBG1&lt;/i&gt; and &lt;i&gt;HBG2&lt;/i&gt; Promoters for Sickle Cell Disease.,2026,10.1056/nejmoa2504835,https://pubmed.ncbi.nlm.nih.gov/41931046/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,40140352,Molecular Characterization of Complex Thalassemia with Multiple Variants in β-Globin Gene Cluster and the Identification of a Novel Structural Rearrangement in γ-Globin Gene.,2025,10.1080/03630269.2025.2484236,https://pubmed.ncbi.nlm.nih.gov/40140352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,40715076,Removal of promoter CpG methylation by epigenome editing reverses HBG silencing.,2025,10.1038/s41467-025-62177-z,https://pubmed.ncbi.nlm.nih.gov/40715076/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,40971495,Infusion of peripheral blood mononuclear cells alleviates amyloid accumulation and cognitive deficits in Alzheimer's disease.,2025,10.1093/gerona/glaf193,https://pubmed.ncbi.nlm.nih.gov/40971495/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,41931047,CRISPR-Cas12a Gene Editing of &lt;i&gt;HBG1&lt;/i&gt; and &lt;i&gt;HBG2&lt;/i&gt; Promoters to Treat Sickle Cell Disease.,2026,10.1056/nejmoa2415550,https://pubmed.ncbi.nlm.nih.gov/41931047/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,41951736,Clinical application of base editing for treating β-thalassaemia.,2026,10.1038/s41586-026-10342-9,https://pubmed.ncbi.nlm.nih.gov/41951736/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,37646679,CRISPR-Cas9 Editing of the &lt;i&gt;HBG1&lt;/i&gt; and &lt;i&gt;HBG2&lt;/i&gt; Promoters to Treat Sickle Cell Disease.,2023,10.1056/nejmoa2215643,https://pubmed.ncbi.nlm.nih.gov/37646679/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,38673849,Pharmacogenomics of Drugs Used in β-Thalassemia and Sickle-Cell Disease: From Basic Research to Clinical Applications.,2024,10.3390/ijms25084263,https://pubmed.ncbi.nlm.nih.gov/38673849/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,39086133,Development and IND-enabling studies of a novel Cas9 genome-edited autologous CD34&lt;sup&gt;+&lt;/sup&gt; cell therapy to induce fetal hemoglobin for sickle cell disease.,2024,10.1016/j.ymthe.2024.07.022,https://pubmed.ncbi.nlm.nih.gov/39086133/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,37298481,Precision Editing as a Therapeutic Approach for β-Hemoglobinopathies.,2023,10.3390/ijms24119527,https://pubmed.ncbi.nlm.nih.gov/37298481/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,39026269,Towards genomic medicine: a tailored next-generation sequencing panel for hydroxyurea pharmacogenomics in Tanzania.,2024,10.1186/s12920-024-01924-5,https://pubmed.ncbi.nlm.nih.gov/39026269/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,35741184,"Single Nucleotide Polymorphisms in XMN1-HBG2, HBS1L-MYB, and BCL11A and Their Relation to High Fetal Hemoglobin Levels That Alleviate Anemia.",2022,10.3390/diagnostics12061374,https://pubmed.ncbi.nlm.nih.gov/35741184/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,37090825,The HBG2 rs7482144 (C > T) Polymorphism is Linked to HbF Levels but not to the Severity of Sickle Cell Anemia.,2023,10.1055/s-0041-1733950,https://pubmed.ncbi.nlm.nih.gov/37090825/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,35656314,Induction of Fetal Hemoglobin by Introducing Natural Hereditary Persistence of Fetal Hemoglobin Mutations in the γ-Globin Gene Promoters for Genome Editing Therapies for β-Thalassemia.,2022,10.3389/fgene.2022.881937,https://pubmed.ncbi.nlm.nih.gov/35656314/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,33509438,Epigenetic regulation of hemoglobin switching in non-human primates.,2021,10.1053/j.seminhematol.2020.12.001,https://pubmed.ncbi.nlm.nih.gov/33509438/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBG2,ENSG00000196565,Unsafe,35553407,Targeting Genetic Modifiers of HBG Gene Expression in Sickle Cell Disease: The miRNA Option.,2022,10.1007/s40291-022-00589-z,https://pubmed.ncbi.nlm.nih.gov/35553407/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,42448285,HTLV-1 HBZ inhibits DHX9 to reprogram circRNA biogenesis in ATLL.,2026,10.1016/j.tvr.2026.200347,https://pubmed.ncbi.nlm.nih.gov/42448285/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,42240309,HTLV-1 Tax and HBZ cooperatively promote leukemogenesis through miR-155-mediated PTEN suppression and PI3K-Akt activation.,2026,10.1128/jvi.00554-26,https://pubmed.ncbi.nlm.nih.gov/42240309/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,42449645,The HTLV-1 HBZ Oncoprotein and Its Role in Adult T-Cell Leukemia/Lymphoma.,2026,10.3390/cancers18132101,https://pubmed.ncbi.nlm.nih.gov/42449645/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,42761267,Integrated bioinformatics and feature selection-based discovery of ADP-ribosylation-associated biomarkers in non-small cell lung cancer.,2026,10.3892/ol.2026.15852,https://pubmed.ncbi.nlm.nih.gov/42761267/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,42710656,A transcription factor-focused CRISPR screen identifies SKI as a BCL11A-independent repressor of ζ-globin.,2026,10.1016/j.jgg.2026.09.003,https://pubmed.ncbi.nlm.nih.gov/42710656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,42106909,Real-time diagnosis of adult T-cell leukemia/lymphoma using HBZ RNA in situ hybridization.,2026,10.1093/ajcp/aqag030,https://pubmed.ncbi.nlm.nih.gov/42106909/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,42115154,HTLV-1 subverts the innate immune effector gene IRF7 by viral HBZ protein for oncogenesis.,2026,10.1038/s41467-026-72980-x,https://pubmed.ncbi.nlm.nih.gov/42115154/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,42588710,Rewiring of the Apoptotic Rheostat in HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma.,2026,10.3390/cancers18152494,https://pubmed.ncbi.nlm.nih.gov/42588710/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,42693121,Author Correction: High expression of Rex-orf-I and HBZ mRNAs and bronchiectasis in lung of HTLV-1A/C infected macaques.,2026,10.1038/s41467-026-77329-y,https://pubmed.ncbi.nlm.nih.gov/42693121/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,40720552,Splicing-dependent restriction of the HBZ gene by Tax underlies biphasic HTLV-1 infection.,2025,10.1371/journal.ppat.1013381,https://pubmed.ncbi.nlm.nih.gov/40720552/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,42492180,Immunophenotype and proviral landscape of HTLV-1c infection and pulmonary disease.,2026,10.1016/j.ebiom.2026.106403,https://pubmed.ncbi.nlm.nih.gov/42492180/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,42667516,CRISPR-mediated excision of HTLV-1 reduces proviral loads in PBMCs from HAM/TSP patients.,2026,10.1007/s13365-026-01333-7,https://pubmed.ncbi.nlm.nih.gov/42667516/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,41107293,Viral oncogenes drive biphenotypic lymphoproliferative malignancy in transgenic mice.,2025,10.1038/s41598-025-20098-3,https://pubmed.ncbi.nlm.nih.gov/41107293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,42230398,From serologic uncertainty to diagnostic clarity in unusual adult T-cell leukemia/lymphoma via HBZ in situ hybridization.,2026,10.1007/s12308-026-00705-6,https://pubmed.ncbi.nlm.nih.gov/42230398/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,41613316,Identification of iron metabolism-related key genes and exploration of their potential mechanisms in hemophagocytic lymphohistiocytosis based on transcriptome sequencing.,2025,10.3389/fmed.2025.1685793,https://pubmed.ncbi.nlm.nih.gov/41613316/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,40549917,JunB-HBZ nuclear translocation by TGF-β is a key driver in HTLV-1-mediated leukemogenesis.,2025,10.1073/pnas.2420756122,https://pubmed.ncbi.nlm.nih.gov/40549917/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,42822251,HTLV-1 and ATL: Decoding Molecular Pathogenesis for Next-Generation Therapies.,2026,10.1016/j.leukres.2026.108326,https://pubmed.ncbi.nlm.nih.gov/42822251/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,41361471,Intra-pol proviral open region of HTLV-1 controls the transcription from both long terminal repeats.,2025,10.1186/s12977-025-00671-4,https://pubmed.ncbi.nlm.nih.gov/41361471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,39892646,Investigating the circadian rhythm signaling pathway in HTLV-1 pathogenesis using Boolean analysis.,2025,10.1016/j.virusres.2025.199539,https://pubmed.ncbi.nlm.nih.gov/39892646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,40431738,HTLV-I Basic Leucine Zipper Factor (sHBZ) Actively Associates with Nucleophosmin (B23) in the Nucleolus.,2025,10.3390/v17050727,https://pubmed.ncbi.nlm.nih.gov/40431738/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,41948833,Highly sensitive HBZ RNA in situ hybridization enables routine pathologic diagnosis of adult T-cell leukemia/lymphoma.,2026,10.1093/ajcp/aqag022,https://pubmed.ncbi.nlm.nih.gov/41948833/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,42201388,Exploiting the Notch pathway in HTLV-1-driven adult T-cell leukemia/lymphoma: a mini-review.,2026,10.1007/s00277-026-07087-w,https://pubmed.ncbi.nlm.nih.gov/42201388/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,40895309,Human T-cell leukemia virus type 1: oncogenic potential and vaccine development strategies.,2025,10.3389/fcimb.2025.1587802,https://pubmed.ncbi.nlm.nih.gov/40895309/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,40431676,"Human T-Lymphotropic Virus (HTLV): Epidemiology, Genetic, Pathogenesis, and Future Challenges.",2025,10.3390/v17050664,https://pubmed.ncbi.nlm.nih.gov/40431676/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,40597293,Intron-oriented HTLV-1 integration in an adult T-cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA.,2025,10.1002/1873-3468.70104,https://pubmed.ncbi.nlm.nih.gov/40597293/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,6539334,Human hemoglobin Portland II (zeta 2 beta 2). Isolation and characterization of Portland hemoglobin components and their constituent globin chains.,1984,10.1016/s0021-9258(17)39875-7,https://pubmed.ncbi.nlm.nih.gov/6539334/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HBZ,ENSG00000130656,Unsafe,6171809,Structure of the zeta chain of human embryonic hemoglobin.,1981,10.1073/pnas.78.10.6076,https://pubmed.ncbi.nlm.nih.gov/6171809/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEATR4,ENSG00000187105,Unsafe,37261792,Genome-Wide Association Study of CKD Progression.,2023,10.1681/asn.0000000000000170,https://pubmed.ncbi.nlm.nih.gov/37261792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEATR9,ENSG00000270379,Unsafe,39884456,Multiomic Sequencing of Intermediate- to High-Risk Cutaneous Squamous Cell Carcinoma Identifies Critical Genes and Expression Patterns Associated with Disease and Poor Outcomes.,2025,10.1016/j.jid.2025.01.015,https://pubmed.ncbi.nlm.nih.gov/39884456/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEATR9,ENSG00000270379,Unsafe,32678841,Heatr9 is an infection responsive gene that affects cytokine production in alveolar epithelial cells.,2020,10.1371/journal.pone.0236195,https://pubmed.ncbi.nlm.nih.gov/32678841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEATR9,ENSG00000270379,Unsafe,35433461,Integrated Multi-Omics Analysis Identified PTPRG and CHL1 as Key Regulators of Immunophenotypes in Clear Cell Renal Cell Carcinoma(ccRCC).,2022,10.3389/fonc.2022.832027,https://pubmed.ncbi.nlm.nih.gov/35433461/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEATR9,ENSG00000270379,Unsafe,33995500,Genome-Wide Analysis Reveals Selection Signatures Involved in Meat Traits and Local Adaptation in Semi-Feral Maremmana Cattle.,2021,10.3389/fgene.2021.675569,https://pubmed.ncbi.nlm.nih.gov/33995500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,41212051,Genetic variants in HELB contribute to premature ovarian insufficiency and early age of natural menopause.,2025,10.1172/jci.insight.191122,https://pubmed.ncbi.nlm.nih.gov/41212051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,40496644,Rare SNP in the &lt;i&gt;HELB&lt;/i&gt; gene interferes with RPA interaction and cellular function of HELB.,2025,10.1093/narmme/ugaf019,https://pubmed.ncbi.nlm.nih.gov/40496644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,41057762,Selective sweeps for mutations increasing height impede identification of causative mutations for fertility and other correlated traits in cattle.,2025,10.1186/s12711-025-01004-x,https://pubmed.ncbi.nlm.nih.gov/41057762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,39939714,"Exome sequencing identifies HELB as a novel susceptibility gene for non-mucinous, non-high-grade-serous epithelial ovarian cancer.",2025,10.1038/s41431-025-01786-0,https://pubmed.ncbi.nlm.nih.gov/39939714/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,40612938,"A novel, rapid, and practical prognostic model for sepsis patients based on dysregulated immune cell lactylation.",2025,10.3389/fimmu.2025.1625311,https://pubmed.ncbi.nlm.nih.gov/40612938/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,40837069,Genome-Wide Association Study and Rare Variant Association Studies of Strabismus in the &lt;i&gt;All of Us&lt;/i&gt; Research Program.,2025,10.1016/j.xops.2025.100873,https://pubmed.ncbi.nlm.nih.gov/40837069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,35385349,Human HELB is a processive motor protein that catalyzes RPA clearance from single-stranded DNA.,2022,10.1073/pnas.2112376119,https://pubmed.ncbi.nlm.nih.gov/35385349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,38577929,Induction of the human CDC45 gene promoter activity by natural compound trans‑resveratrol.,2024,10.3892/mmr.2024.13216,https://pubmed.ncbi.nlm.nih.gov/38577929/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,35391795,Whole-Genome Analyses Reveal Genomic Characteristics and Selection Signatures of Lincang Humped Cattle at the China-Myanmar Border.,2022,10.3389/fgene.2022.833503,https://pubmed.ncbi.nlm.nih.gov/35391795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,32455610,Genome Maintenance by DNA Helicase B.,2020,10.3390/genes11050578,https://pubmed.ncbi.nlm.nih.gov/32455610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,32478505,The Expression of Human DNA Helicase B Is Affected by G-Quadruplexes in the Promoter.,2020,10.1021/acs.biochem.0c00218,https://pubmed.ncbi.nlm.nih.gov/32478505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,36983731,High-Throughput Sequencing Reveals That Rotundine Inhibits Colorectal Cancer by Regulating Prognosis-Related Genes.,2023,10.3390/jpm13030550,https://pubmed.ncbi.nlm.nih.gov/36983731/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,32460767,Selection signatures in tropical cattle are enriched for promoter and coding regions and reveal missense mutations in the damage response gene HELB.,2020,10.1186/s12711-020-00546-6,https://pubmed.ncbi.nlm.nih.gov/32460767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,27079536,Characterization of the 5'-flanking region of the human DNA helicase B (HELB) gene and its response to trans-Resveratrol.,2016,10.1038/srep24510,https://pubmed.ncbi.nlm.nih.gov/27079536/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,26774285,HELB Is a Feedback Inhibitor of DNA End Resection.,2016,10.1016/j.molcel.2015.12.013,https://pubmed.ncbi.nlm.nih.gov/26774285/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,32377740,Effect of the natural compound trans‑resveratrol on human MCM4 gene transcription.,2020,10.3892/or.2020.7598,https://pubmed.ncbi.nlm.nih.gov/32377740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,35131473,Signatures of selection in Nelore cattle revealed by whole-genome sequencing data.,2022,10.1016/j.ygeno.2022.110304,https://pubmed.ncbi.nlm.nih.gov/35131473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,35493704,Rare coding variants in DNA damage repair genes associated with timing of natural menopause.,2022,10.1016/j.xhgg.2021.100079,https://pubmed.ncbi.nlm.nih.gov/35493704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,30567999,"Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination.",2019,10.1101/gad.315978.118,https://pubmed.ncbi.nlm.nih.gov/30567999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,23785023,"Genome-wide association study for inhibin, luteinizing hormone, insulin-like growth factor 1, testicular size and semen traits in bovine species.",2013,10.1111/j.2047-2927.2013.00101.x,https://pubmed.ncbi.nlm.nih.gov/23785023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELB,ENSG00000127311,Unsafe,12181327,A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication.,2002,10.1074/jbc.m208067200,https://pubmed.ncbi.nlm.nih.gov/12181327/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,42806713,HELQ &amp; Hel308: ancient enzymes of DNA repair and recombination.,2026,10.1042/bst20250255,https://pubmed.ncbi.nlm.nih.gov/42806713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,42812823,ABRAXAS1-HELQ is a candidate class-matched reference chimeric RNA and contributes to prostate cell motility through MCOLN2.,2026,10.3389/fonc.2026.1935441,https://pubmed.ncbi.nlm.nih.gov/42812823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,42055550,The DNA helicase HELQ promotes replication fork reversal in coordination with BRCA2- and FANCD2-mediated repair pathways.,2026,10.1093/nar/gkag332,https://pubmed.ncbi.nlm.nih.gov/42055550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,37921071,HELQ as a DNA helicase: Its novel role in normal cell function and tumorigenesis (Review).,2023,10.3892/or.2023.8657,https://pubmed.ncbi.nlm.nih.gov/37921071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,40381483,HELQ upregulates PARP1 to drive platinum resistance and predict therapeutic response in ovarian cancer.,2025,10.1016/j.tranon.2025.102416,https://pubmed.ncbi.nlm.nih.gov/40381483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,41748611,An information theory approach to quantifying the sequence-dependent response of nucleic acid motors with applications to nanopore DNA sequencing.,2026,10.1038/s41467-026-69867-2,https://pubmed.ncbi.nlm.nih.gov/41748611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,40542648,HELQ Maintains Genome Stability of Primordial Germ Cells by Inhibiting LINE-1 Expression.,2025,10.1096/fj.202403260r,https://pubmed.ncbi.nlm.nih.gov/40542648/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,41713536,Integration of TWAS with single-cell and spatial transcriptomics identifies TLR1 as a susceptibility gene and therapeutic target in the breast cancer tumor microenvironment.,2026,10.1016/j.ijbiomac.2026.150951,https://pubmed.ncbi.nlm.nih.gov/41713536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,37409572,Archaeal Hel308 suppresses recombination through a catalytic switch that controls DNA annealing.,2023,10.1093/nar/gkad572,https://pubmed.ncbi.nlm.nih.gov/37409572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,39965657,The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution.,2025,10.1098/rsob.240112,https://pubmed.ncbi.nlm.nih.gov/39965657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,38720471,HELQ deficiency impairs the induction of primordial germ cell-like cells.,2024,10.1002/2211-5463.13810,https://pubmed.ncbi.nlm.nih.gov/38720471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,39201320,Helicase HELQ: Molecular Characters Fit for DSB Repair Function.,2024,10.3390/ijms25168634,https://pubmed.ncbi.nlm.nih.gov/39201320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,38540391,A Human Homozygous HELQ Missense Variant Does Not Cause Premature Ovarian Insufficiency in a Mouse Model.,2024,10.3390/genes15030333,https://pubmed.ncbi.nlm.nih.gov/38540391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,39530221,CRISPR knockout genome-wide screens identify the HELQ-RAD52 axis in regulating the repair of cisplatin-induced single-stranded DNA gaps.,2024,10.1093/nar/gkae998,https://pubmed.ncbi.nlm.nih.gov/39530221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,37897354,Human HELQ regulates DNA end resection at DNA double-strand breaks and stalled replication forks.,2023,10.1093/nar/gkad940,https://pubmed.ncbi.nlm.nih.gov/37897354/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,40082407,FAN1-mediated translesion synthesis and POLQ/HELQ-mediated end joining generate interstrand crosslink-induced mutations.,2025,10.1038/s41467-025-57764-z,https://pubmed.ncbi.nlm.nih.gov/40082407/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,36183369,HELQ suppresses migration and proliferation of non-small cell lung cancer cells by repairing DNA damage and inducing necrosis.,2023,10.1002/cbin.11922,https://pubmed.ncbi.nlm.nih.gov/36183369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,38500564,Evolutionary and functional insights into the Ski2-like helicase family in Archaea: a comparison of Thermococcales ASH-Ski2 and Hel308 activities.,2024,10.1093/nargab/lqae026,https://pubmed.ncbi.nlm.nih.gov/38500564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,36718939,Interaction of human HelQ with DNA polymerase delta halts DNA synthesis and stimulates DNA single-strand annealing.,2023,10.1093/nar/gkad032,https://pubmed.ncbi.nlm.nih.gov/36718939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,37777152,Mitotic DNA Synthesis in Untransformed Human Cells Preserves Common Fragile Site Stability via a FANCD2-Driven Mechanism That Requires HELQ.,2023,10.1016/j.jmb.2023.168294,https://pubmed.ncbi.nlm.nih.gov/37777152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,33485349,HELQ and EGR3 expression correlate with IGHV mutation status and prognosis in chronic lymphocytic leukemia.,2021,10.1186/s12967-021-02708-6,https://pubmed.ncbi.nlm.nih.gov/33485349/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,27792995,Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.,2016,10.18632/oncotarget.12818,https://pubmed.ncbi.nlm.nih.gov/27792995/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,32706021,Mechanistic insights into Lhr helicase function in DNA repair.,2020,10.1042/bcj20200379,https://pubmed.ncbi.nlm.nih.gov/32706021/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,26636256,Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.,2015,10.1016/j.str.2015.10.014,https://pubmed.ncbi.nlm.nih.gov/26636256/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,28118297,Genetic variants of age at menopause are not related to timing of ovarian failure in breast cancer survivors.,2017,10.1097/gme.0000000000000817,https://pubmed.ncbi.nlm.nih.gov/28118297/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,22267201,Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.,2012,10.1038/ng.1051,https://pubmed.ncbi.nlm.nih.gov/22267201/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HELQ,ENSG00000163312,Unsafe,23504502,Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population.,2013,10.1093/carcin/bgt094,https://pubmed.ncbi.nlm.nih.gov/23504502/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,41681505,GWAS-Identified SNPs and Candidate Genes Influencing Sex in Loach (&lt;i&gt;Misgurnus anguillicaudatus&lt;/i&gt;).,2026,10.3390/ani16030524,https://pubmed.ncbi.nlm.nih.gov/41681505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,39374784,Upregulation of nuclear protein Hemgn by transcriptional repressor Gfi1 through repressing PU.1 contributes to the anti-apoptotic activity of Gfi1.,2024,10.1016/j.jbc.2024.107860,https://pubmed.ncbi.nlm.nih.gov/39374784/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,36563642,Cancer/testis antigen HEMGN correlated with immune infiltration serves as a prognostic biomarker in lung adenocarcinoma.,2023,10.1016/j.molimm.2022.12.008,https://pubmed.ncbi.nlm.nih.gov/36563642/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,40262274,Bcl-xL is important for the antiapoptotic activity of Gfi1 and is upregulated by Gfi1 through hemgn.,2025,10.1093/jimmun/vkae066,https://pubmed.ncbi.nlm.nih.gov/40262274/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,40963580,Machine learning-based integration develops an immune-derived signature for diagnosing high-altitude pulmonary hypertension.,2025,10.3389/fmed.2025.1603140,https://pubmed.ncbi.nlm.nih.gov/40963580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,39273679,Short Communication: Novel Di- and Triselenoesters as Effective Therapeutic Agents Inhibiting Multidrug Resistance Proteins in Breast Cancer Cells.,2024,10.3390/ijms25179732,https://pubmed.ncbi.nlm.nih.gov/39273679/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,33203523,Circ_PSD3 promotes the progression of papillary thyroid carcinoma via the miR-637/HEMGN axis.,2021,10.1016/j.lfs.2020.118622,https://pubmed.ncbi.nlm.nih.gov/33203523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,34923767,Hemgn Protects Hematopoietic Stem and Progenitor Cells Against Transplantation Stress Through Negatively Regulating IFN-γ Signaling.,2022,10.1002/advs.202103838,https://pubmed.ncbi.nlm.nih.gov/34923767/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,39063006,Di- and Triselenoesters-Promising Drug Candidates for the Future Therapy of Triple-Negative Breast Cancer.,2024,10.3390/ijms25147764,https://pubmed.ncbi.nlm.nih.gov/39063006/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,34573441,Genetic Regulation of Avian Testis Development.,2021,10.3390/genes12091459,https://pubmed.ncbi.nlm.nih.gov/34573441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,33451334,HEMGN and SLC2A1 might be potential diagnostic biomarkers of steroid-induced osteonecrosis of femoral head: study based on WGCNA and DEGs screening.,2021,10.1186/s12891-021-03958-7,https://pubmed.ncbi.nlm.nih.gov/33451334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,37760841,Establishing Molecular Subgroups of CD8+ T Cell-Associated Genes in the Ovarian Cancer Tumour Microenvironment and Predicting the Immunotherapy Response.,2023,10.3390/biomedicines11092399,https://pubmed.ncbi.nlm.nih.gov/37760841/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,32350948,EDAG mediates Hsp70 nuclear localization in erythroblasts and rescues dyserythropoiesis in myelodysplastic syndrome.,2020,10.1096/fj.201902946r,https://pubmed.ncbi.nlm.nih.gov/32350948/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,35581635,The m6A methylation regulates gonadal sex differentiation in chicken embryo.,2022,10.1186/s40104-022-00710-6,https://pubmed.ncbi.nlm.nih.gov/35581635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,37791839,Single-cell RNA seq analysis of erythroid cells reveals a specific sub-population of stress erythroid progenitors.,2023,10.1080/16078454.2023.2261802,https://pubmed.ncbi.nlm.nih.gov/37791839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,38139431,DNA Copy Number Alterations and Copy Neutral Loss of Heterozygosity in Adult Ph-Negative Acute B-Lymphoblastic Leukemia: Focus on the Genes Involved.,2023,10.3390/ijms242417602,https://pubmed.ncbi.nlm.nih.gov/38139431/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,33903625,Gene network and biological pathways associated with susceptibility to differentiated thyroid carcinoma.,2021,10.1038/s41598-021-88253-0,https://pubmed.ncbi.nlm.nih.gov/33903625/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,35514346,Single Cell RNA-Seq Analysis of Human Red Cells.,2022,10.3389/fphys.2022.828700,https://pubmed.ncbi.nlm.nih.gov/35514346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,29324880,EDAG promotes the expansion and survival of human CD34+ cells.,2018,10.1371/journal.pone.0190794,https://pubmed.ncbi.nlm.nih.gov/29324880/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,26278353,The busulfan metabolite EdAG irreversibly glutathionylates glutaredoxins.,2015,10.1016/j.abb.2015.08.005,https://pubmed.ncbi.nlm.nih.gov/26278353/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,26501085,Supporting data for characterization of the busulfan metabolite EdAG and the Glutaredoxins that it adducts.,2015,10.1016/j.dib.2015.09.002,https://pubmed.ncbi.nlm.nih.gov/26501085/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,26907258,Assessment of Radiation Induced Therapeutic Effect and Cytotoxicity in Cancer Patients Based on Transcriptomic Profiling.,2016,10.3390/ijms17020250,https://pubmed.ncbi.nlm.nih.gov/26907258/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,18791061,Dehydroalanine analog of glutathione: an electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1.,2008,10.1124/jpet.108.142208,https://pubmed.ncbi.nlm.nih.gov/18791061/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,15522166,[Expression of EDAG-1 gene in human leukemia and lymphoma cell lines].,2004,,https://pubmed.ncbi.nlm.nih.gov/15522166/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,23436708,Scanning of novel cancer/testis proteins by human testis proteomic analysis.,2013,10.1002/pmic.201200489,https://pubmed.ncbi.nlm.nih.gov/23436708/,annotation citations | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,25803042,T-cell activation and early gene response in dogs.,2015,10.1371/journal.pone.0121169,https://pubmed.ncbi.nlm.nih.gov/25803042/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,21343615,Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells.,2011,10.1182/blood-2010-12-323212,https://pubmed.ncbi.nlm.nih.gov/21343615/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,15920494,High expression of EDAG and its significance in AML.,2005,10.1038/sj.leu.2403808,https://pubmed.ncbi.nlm.nih.gov/15920494/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,15332117,EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-kappa B.,2004,10.1038/sj.cdd.4401490,https://pubmed.ncbi.nlm.nih.gov/15332117/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,14730214,Down-regulation of human NDR gene in megakaryocytic differentiation of erythroleukemia K562 cells.,2004,10.1007/bf02256553,https://pubmed.ncbi.nlm.nih.gov/14730214/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,14648837,Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis.,2003,10.1002/dvdy.10399,https://pubmed.ncbi.nlm.nih.gov/14648837/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HEMGN,ENSG00000136929,Unsafe,11404085,"Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms.",2001,10.1016/s0925-4773(01)00376-8,https://pubmed.ncbi.nlm.nih.gov/11404085/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,42343633,HENMT1: an RNA methyltransferase in biology and disease.,2026,10.1631/jzus.b2500059,https://pubmed.ncbi.nlm.nih.gov/42343633/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,42625859,"Dysregulation of piRNA biogenesis-associated proteins in cancer: mechanisms, evidence, and translational constraints.",2026,10.3389/fmolb.2026.1906635,https://pubmed.ncbi.nlm.nih.gov/42625859/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,39318356,A homozygous nonsense variant in HENMT1 causes male infertility in humans and mice.,2025,10.1111/andr.13767,https://pubmed.ncbi.nlm.nih.gov/39318356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,39849452,Development and validation of a novel artificial intelligence algorithm for precise prediction the postoperative prognosis of esophageal squamous cell carcinoma.,2025,10.1186/s12885-025-13520-6,https://pubmed.ncbi.nlm.nih.gov/39849452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,39120570,Phenotypic continuum and poor intracytoplasmic sperm injection intracytoplasmic sperm injection prognosis in patients harboring HENMT1 variants.,2025,10.1111/andr.13730,https://pubmed.ncbi.nlm.nih.gov/39120570/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,38065897,Screening of potential key genes in esophageal cancer based on RBP and expression verification of HENMT1.,2023,10.1097/md.0000000000036544,https://pubmed.ncbi.nlm.nih.gov/38065897/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,39118140,DNA methylation correlates of chronological age in diverse human tissue types.,2024,10.1186/s13072-024-00546-6,https://pubmed.ncbi.nlm.nih.gov/39118140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,38198468,Molecular basis of the reaction mechanism of the methyltransferase HENMT1.,2024,10.1371/journal.pone.0293243,https://pubmed.ncbi.nlm.nih.gov/38198468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,40645105,Novel homozygous variants in piRNA pathway factors lead to male infertility in humans.,2025,10.1016/j.rbmo.2025.104974,https://pubmed.ncbi.nlm.nih.gov/40645105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,32375858,Integrative analyses of the RNA modification machinery reveal tissue- and cancer-specific signatures.,2020,10.1186/s13059-020-02009-z,https://pubmed.ncbi.nlm.nih.gov/32375858/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,35449547,Exploring Potential Regulatory Anesthetic Drugs Based on RNA Binding Protein and Constructing CESC Prognosis Model: A Study Based on TCGA Database.,2022,10.3389/fsurg.2022.823566,https://pubmed.ncbi.nlm.nih.gov/35449547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,35172124,Whole-exome sequencing improves the diagnosis and care of men with non-obstructive azoospermia.,2022,10.1016/j.ajhg.2022.01.011,https://pubmed.ncbi.nlm.nih.gov/35172124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,32542340,3'-Terminal 2'-O-methylation of lung cancer miR-21-5p enhances its stability and association with Argonaute 2.,2020,10.1093/nar/gkaa504,https://pubmed.ncbi.nlm.nih.gov/32542340/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,34590701,HENMT1 is involved in the maintenance of normal female fertility in the mouse.,2021,10.1093/molehr/gaab061,https://pubmed.ncbi.nlm.nih.gov/34590701/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,28676534,Expression patterns of HENMT1 and PIWIL1 in human testis: implications for transposon expression.,2017,10.1530/rep-16-0586,https://pubmed.ncbi.nlm.nih.gov/28676534/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,36626444,The exploration of new biomarkers for oral cancer through the ceRNA network and immune microenvironment analysis.,2022,10.1097/md.0000000000032249,https://pubmed.ncbi.nlm.nih.gov/36626444/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,26496356,HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse.,2015,10.1371/journal.pgen.1005620,https://pubmed.ncbi.nlm.nih.gov/26496356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,35739227,Construction of a four-mRNA prognostic signature with its ceRNA network in CESC.,2022,10.1038/s41598-022-14732-7,https://pubmed.ncbi.nlm.nih.gov/35739227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,33374923,A Comprehensive Molecular and Clinical Analysis of the piRNA Pathway Genes in Ovarian Cancer.,2020,10.3390/cancers13010004,https://pubmed.ncbi.nlm.nih.gov/33374923/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HENMT1,ENSG00000162639,Unsafe,34863153,Expression profile of RNA binding protein in cervical cancer using bioinformatics approach.,2021,10.1186/s12935-021-02319-7,https://pubmed.ncbi.nlm.nih.gov/34863153/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,42055552,The interferon-stimulated gene product HERC5 inhibits human LINE-1 retrotransposition with an ISGylation-independent mechanism.,2026,10.1093/nar/gkag334,https://pubmed.ncbi.nlm.nih.gov/42055552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,42858644,Integrative bulk and single-cell transcriptomics identifies a HERC5-linked immune-attenuated risk program for pulmonary metastasis/relapse in osteosarcoma.,2026,10.1016/j.tranon.2026.103070,https://pubmed.ncbi.nlm.nih.gov/42858644/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,42442365,"Understanding protein ISGylation, a multifaceted posttranslational modification.",2026,10.1016/j.chembiol.2026.06.006,https://pubmed.ncbi.nlm.nih.gov/42442365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,42436521,Modification of PCNA by ISG15 plays a crucial role in porcine deltacoronavirus infection.,2026,10.1186/s13567-026-01802-1,https://pubmed.ncbi.nlm.nih.gov/42436521/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,42595063,TBX15 increases ferroptosis to overcome sorafenib resistance via HERC5-mediated cGAS ISGylation in hepatocellular carcinoma.,2026,10.1016/j.freeradbiomed.2026.08.027,https://pubmed.ncbi.nlm.nih.gov/42595063/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,40045362,E3 ligase HERC5-catalyzed UGDH isgylation promotes SNAI1-mediated tumor metastasis and cisplatin resistance in oral squamous cell carcinoma.,2025,10.1186/s13062-025-00622-1,https://pubmed.ncbi.nlm.nih.gov/40045362/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,41404913,Albendazole Suppresses SARS-CoV-2 Replication by Enhancing HERC5-Mediated ISGylation of Nucleocapsid Protein.,2025,10.1002/jmv.70751,https://pubmed.ncbi.nlm.nih.gov/41404913/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,42023152,ISGylation is disrupted by &lt;i&gt;UBA7&lt;/i&gt; gene variants identified in individuals with neurodevelopmental disorder phenotypes.,2026,10.1016/j.isci.2026.115454,https://pubmed.ncbi.nlm.nih.gov/42023152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,41432807,"HERC5, IFI6, IFIT3, and OASL as potential diagnostic biomarkers for systemic lupus erythematosus: an integrated bioinformatics, machine learning and clinical validation.",2026,10.1007/s10067-025-07880-4,https://pubmed.ncbi.nlm.nih.gov/41432807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,39911484,Sequential transcriptome profiling: comparative analysis of normal and canine lymphoma preceding detailed T-cell and B-cell subtype comparison.,2024,10.3389/fvets.2024.1473421,https://pubmed.ncbi.nlm.nih.gov/39911484/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,39776018,HERC5/ISG15 Enhances Glioblastoma Stemness and Tumor Progression by mediating SERBP1protein stability.,2025,10.1007/s12017-024-08826-w,https://pubmed.ncbi.nlm.nih.gov/39776018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,39062994,"Fish HERC7: Phylogeny, Characterization, and Potential Implications for Antiviral Immunity in European Sea Bass.",2024,10.3390/ijms25147751,https://pubmed.ncbi.nlm.nih.gov/39062994/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,42393313,ISGylation-mediated stabilization of CYP4Z1 fuels breast cancer initiation and progression.,2026,10.1038/s12276-026-01766-4,https://pubmed.ncbi.nlm.nih.gov/42393313/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,41551039,COVID-19 immunopathological features for the prediction and prevention of future emerging respiratory viral infections.,2026,10.1016/j.csbj.2025.12.024,https://pubmed.ncbi.nlm.nih.gov/41551039/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,41748950,CDK8 phosphorylates SOX2 to maintain stemness of pituitary adenoma.,2026,10.1038/s41388-026-03710-2,https://pubmed.ncbi.nlm.nih.gov/41748950/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,41081462,EBV genome-guided transcriptomic re-annotation reveals molecular subtypes of nasopharyngeal carcinoma informing prognosis and treatment.,2026,10.4193/rhin25.274,https://pubmed.ncbi.nlm.nih.gov/41081462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,42177068,Transcriptomic profiling reveals immune pathway dysregulation and key interferon-responsive genes in Systemic Lupus Erythematosus.,2026,10.1016/bs.apcsb.2025.10.003,https://pubmed.ncbi.nlm.nih.gov/42177068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,39254691,Identification of novel protein biomarkers and therapeutic targets for ankylosing spondylitis using human circulating plasma proteomics and genome analysis.,2024,10.1007/s00216-024-05521-4,https://pubmed.ncbi.nlm.nih.gov/39254691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,38605423,HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis.,2024,10.1186/s13046-024-03020-z,https://pubmed.ncbi.nlm.nih.gov/38605423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,41098736,&lt;i&gt;CLEC4E&lt;/i&gt; as a molecular biomarker in systemic lupus erythematosus: integrating bioinformatics and clinical data to assess its prognostic value.,2025,10.3389/fimmu.2025.1617878,https://pubmed.ncbi.nlm.nih.gov/41098736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,40280045,Insight into mechanism of ALKBH5-mediated N&lt;sup&gt;6&lt;/sup&gt;-methyladenosine (m&lt;sup&gt;6&lt;/sup&gt;A) regulating porcine epidemic diarrhea virus infection in IPEC-J2 cells.,2025,10.1016/j.ijbiomac.2025.143501,https://pubmed.ncbi.nlm.nih.gov/40280045/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,38444851,Immunological signatures unveiled by integrative systems vaccinology characterization of dengue vaccination trials and natural infection.,2024,10.3389/fimmu.2024.1282754,https://pubmed.ncbi.nlm.nih.gov/38444851/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,39722731,Molecular Differences in Glomerular Compartment to Distinguish Immunoglobulin A Nephropathy and Lupus Nephritis.,2024,10.2147/jir.s496138,https://pubmed.ncbi.nlm.nih.gov/39722731/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,41915616,"Gut Microbiome, Immune Cells, and Heart Failure: A Multi-Omics Mendelian Randomization Study.",2026,10.1159/000550655,https://pubmed.ncbi.nlm.nih.gov/41915616/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,39073262,Autophagy Deficiency Induced by SAT1 Potentiates Tumor Progression in Triple-Negative Breast Cancer.,2024,10.1002/advs.202309903,https://pubmed.ncbi.nlm.nih.gov/39073262/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,40020829,Whole-exome sequencing identifies EP300 variants associated with visceral leishmaniasis relapse.,2025,10.1016/j.ijbiomac.2025.141533,https://pubmed.ncbi.nlm.nih.gov/40020829/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,40996888,Genome-Wide Aggregated Trans-Effects Analysis Implicates Deficient Type III Interferon Signaling as a Key Cause of Inflammatory Bowel Disease.,2025,10.1093/ibd/izaf214,https://pubmed.ncbi.nlm.nih.gov/40996888/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,39512937,Suppression of SARS-CoV-2 nucleocapsid protein dimerization by ISGylation and its counteraction by viral PLpro.,2024,10.3389/fmicb.2024.1490944,https://pubmed.ncbi.nlm.nih.gov/39512937/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,37417777,African swine fever virus MGF-360-10L is a novel and crucial virulence factor that mediates ubiquitination and degradation of JAK1 by recruiting the E3 ubiquitin ligase HERC5.,2023,10.1128/mbio.00606-23,https://pubmed.ncbi.nlm.nih.gov/37417777/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,36807122,Metastasis-Related Signature for Clinically Predicting Prognosis and Tumor Immune Microenvironment of Osteosarcoma Patients.,2023,10.1007/s12033-023-00681-7,https://pubmed.ncbi.nlm.nih.gov/36807122/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,40184173,MDA5 ISGylation is crucial for immune signaling to control viral replication and pathogenesis.,2025,10.1073/pnas.2420190122,https://pubmed.ncbi.nlm.nih.gov/40184173/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,39120134,SARS-CoV-2 papain-like protease inhibits ISGylation of the viral nucleocapsid protein to evade host anti-viral immunity.,2024,10.1128/jvi.00855-24,https://pubmed.ncbi.nlm.nih.gov/39120134/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,38507132,Identification of EPSTI1 as a new potential biomarker for SLE based on GEO database.,2024,10.1007/s10067-024-06881-z,https://pubmed.ncbi.nlm.nih.gov/38507132/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,15331633,"HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells.",2004,10.1242/jcs.01338,https://pubmed.ncbi.nlm.nih.gov/15331633/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HERC5,ENSG00000138646,Unsafe,10581175,A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins.,1999,10.1006/bbrc.1999.1777,https://pubmed.ncbi.nlm.nih.gov/10581175/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HINT3,ENSG00000111911,Unsafe,40755357,The Role of HINT3 in Myocardial Ischemia-Reperfusion Injury in Male Mice: Mechanisms Involving SDHA and its Acetylation.,2025,10.1002/advs.202503109,https://pubmed.ncbi.nlm.nih.gov/40755357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HINT3,ENSG00000111911,Unsafe,40376595,USP11 Promotes Endothelial Apoptosis-Resistance in Pulmonary Arterial Hypertension by Deubiquitinating HINT3.,2025,10.70322/jrbtm.2025.10002,https://pubmed.ncbi.nlm.nih.gov/40376595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HINT3,ENSG00000111911,Unsafe,41516028,Endometriosis: From Genes to Global Burden.,2025,10.3390/ijms27010151,https://pubmed.ncbi.nlm.nih.gov/41516028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HINT3,ENSG00000111911,Unsafe,37203409,HINT3 suppresses AKT/mTOR signaling pathway activity during breast cancer tumorigenesis through PTEN transcriptional activation.,2023,10.3892/ijmm.2023.5257,https://pubmed.ncbi.nlm.nih.gov/37203409/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HINT3,ENSG00000111911,Unsafe,39164264,Haplotype analysis identifies functional elements in monoclonal gammopathy of unknown significance.,2024,10.1038/s41408-024-01121-8,https://pubmed.ncbi.nlm.nih.gov/39164264/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HINT3,ENSG00000111911,Unsafe,37311930,Integrated Machine Learning and Bioinformatic Analyses Constructed a Network Between Mitochondrial Dysfunction and Immune Microenvironment of Periodontitis.,2023,10.1007/s10753-023-01851-0,https://pubmed.ncbi.nlm.nih.gov/37311930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HINT3,ENSG00000111911,Unsafe,38033384,"A Systems Biology Approach for Investigating Significant Biomarkers and Drug Targets Common Among Patients with Gonorrhea, Chlamydia, and Prostate Cancer: A Pilot Study.",2023,10.1177/11779322231214445,https://pubmed.ncbi.nlm.nih.gov/38033384/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HINT3,ENSG00000111911,Unsafe,38245717,The integration of multidisciplinary approaches revealed PTGES3 as a novel drug target for breast cancer treatment.,2024,10.1186/s12967-024-04899-0,https://pubmed.ncbi.nlm.nih.gov/38245717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HINT3,ENSG00000111911,Unsafe,34504491,The Role of Hemoglobin Subunit Delta in the Immunopathy of Multiple Sclerosis: Mitochondria Matters.,2021,10.3389/fimmu.2021.709173,https://pubmed.ncbi.nlm.nih.gov/34504491/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HINT3,ENSG00000111911,Unsafe,36520227,Redox homeostasis at SAM: a new role of HINT protein.,2022,10.1007/s00425-022-04044-5,https://pubmed.ncbi.nlm.nih.gov/36520227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HINT3,ENSG00000111911,Unsafe,12748294,The histidine triad protein Hint is not required for murine development or Cdk7 function.,2003,10.1128/mcb.23.11.3929-3935.2003,https://pubmed.ncbi.nlm.nih.gov/12748294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HINT3,ENSG00000111911,Unsafe,21303680,Monocyte-mediated regulation of genes by the amyloid and prion peptides in SH-SY5Y neuroblastoma cells.,2011,10.1016/j.neuint.2011.01.019,https://pubmed.ncbi.nlm.nih.gov/21303680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HINT3,ENSG00000111911,Unsafe,23298258,All-trans retinoic acid protects hepatocellular carcinoma cells against serum-starvation-induced cell death by upregulating collagen 8A2.,2013,10.1111/febs.12122,https://pubmed.ncbi.nlm.nih.gov/23298258/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,42371219,HIPK3 silencing promotes M2 macrophage polarization through NF-κB signaling pathway to enhance oral cancer progression.,2026,10.1007/s00438-026-02476-2,https://pubmed.ncbi.nlm.nih.gov/42371219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,40862172,"MiR-15a-5p, c-MYB, and circHIPK3 Axis as a Potential Diagnostic and Clinicopathological-Related Network in Acute Myeloid Leukemia.",2025,10.4103/abr.abr_252_24,https://pubmed.ncbi.nlm.nih.gov/40862172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,40696229,Circ-Hipk3 in Adipose Derived Stem Cells Exosome Alleviates Myocardial Infarction Induced Myocardial Damage by Regulation miR-138-5p/Sirt1 Axis Mediated Autophagy.,2026,10.1007/s10528-025-11173-5,https://pubmed.ncbi.nlm.nih.gov/40696229/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,40280416,WWP1 mediates the ubiquitination and degradation of HIPK3 in bladder cancer cells.,2025,10.1016/j.jbc.2025.108528,https://pubmed.ncbi.nlm.nih.gov/40280416/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,39602044,HIPK3 hypomethylation as a potential epigenetic biomarker in rheumatic immune diseases with emphasis on rheumatoid arthritis.,2025,10.1007/s10067-024-07158-1,https://pubmed.ncbi.nlm.nih.gov/39602044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,38105269,Overexpression of microRNA-205-5p promotes cholangiocarcinoma growth by reducing expression of homeodomain-interacting protein kinase 3.,2023,10.1038/s41598-023-49694-x,https://pubmed.ncbi.nlm.nih.gov/38105269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,41132727,From miRNA sponges to mTOR blockades: mapping the multidimensional landscape of ameloblastoma pathogenesis and precision targeting.,2025,10.3389/fonc.2025.1651236,https://pubmed.ncbi.nlm.nih.gov/41132727/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,39572643,Circular RNA HIPK3 mediates epithelial-mesenchymal transition of retinal pigment epithelial cells by sponging multiple microRNAs.,2024,10.1038/s41598-024-71119-6,https://pubmed.ncbi.nlm.nih.gov/39572643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,40505000,"Evaluation of CD73, PD-1, circHIPK3, and circNRIP1 expression in the peripheral blood of patients with colorectal cancer.",2025,10.1093/labmed/lmaf015,https://pubmed.ncbi.nlm.nih.gov/40505000/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,39137856,Exploring the role of circ-0091579/miR-1225-5p and circ-HIPK3/miR-338-3p axes in the pathogenesis of postmenopausal osteoporosis.,2024,10.1016/j.ijbiomac.2024.134688,https://pubmed.ncbi.nlm.nih.gov/39137856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,39503793,"Immune Regulatory Circular RNAs, circRasGEF1B and circHIPK3, are Upregulated in Peripheral Blood Mononuclear Cells of COVID-19 Patients.",2024,10.1089/gtmb.2024.0337,https://pubmed.ncbi.nlm.nih.gov/39503793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,42149098,circHIPK3 Sustains Ribosome Biogenesis and Protects Against Cardiac Aging by Stabilizing Ncl mRNA and Supporting its LLPS.,2026,10.14336/ad.2026.0142,https://pubmed.ncbi.nlm.nih.gov/42149098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,42594677,"Discovery of 2, 4-disubstituted pyrimidine derivatives as selective HIPK2 inhibitors for potential treatment of chronic kidney disease.",2026,10.1016/j.ejmech.2026.119215,https://pubmed.ncbi.nlm.nih.gov/42594677/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,40374541,Development and Evaluation of a Droplet Digital PCR Assay for the Accurately Detecting the CircHIPK3 in Plasma Samples from Patients with Hepatocellular Carcinoma.,2025,10.4014/jmb.2412.12048,https://pubmed.ncbi.nlm.nih.gov/40374541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,40316684,PDGF-BB promotes oral submucosal fibrosis by driving phenotypic transformation and autophagy in oral mucosal fibroblasts through downregulation of circHIPK3.,2025,10.1038/s41598-025-99753-8,https://pubmed.ncbi.nlm.nih.gov/40316684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,38322996,Exosomal miR-3174 induced by hypoxia promotes angiogenesis and metastasis of hepatocellular carcinoma by inhibiting HIPK3.,2024,10.1016/j.isci.2024.108955,https://pubmed.ncbi.nlm.nih.gov/38322996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,37581369,MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by regulating HIPK3 expression.,2023,10.1042/bsr20230014,https://pubmed.ncbi.nlm.nih.gov/37581369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,40673270,Overexpression of GDF15 protects kidneys from ischemia reperfusion injury and affects circular RNA expression.,2025,10.3389/fcell.2025.1577625,https://pubmed.ncbi.nlm.nih.gov/40673270/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,37865877,"Role of The circ-HIPK3, circ-PVT1, miR-25, and miR-149 in Response of Breast Cancer Cells to Ionizing Radiation.",2023,10.22074/cellj.2023.1995943.1255,https://pubmed.ncbi.nlm.nih.gov/37865877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,36703984,DNA methylation change of HIPK3 in Chinese rheumatoid arthritis and its effect on inflammation.,2022,10.3389/fimmu.2022.1087279,https://pubmed.ncbi.nlm.nih.gov/36703984/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,39318256,[Research Progress of Circular RNA CircHIPK3 in Non-small Cell Lung Cancer].,2024,10.3779/j.issn.1009-3419.2024.106.20,https://pubmed.ncbi.nlm.nih.gov/39318256/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,35434020,MiR-146a upregulates FOXP3 and suppresses inflammation by targeting HIPK3/STAT3 in allergic conjunctivitis.,2022,10.21037/atm-22-982,https://pubmed.ncbi.nlm.nih.gov/35434020/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,34741261,Inhibition of HIPK3 by AST487 Ameliorates Mutant HTT-Induced Neurotoxicity and Apoptosis via Enhanced Autophagy.,2022,10.1007/s12264-021-00783-9,https://pubmed.ncbi.nlm.nih.gov/34741261/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,33495417,Identification of HIPK3 as a potential biomarker and an inhibitor of clear cell renal cell carcinoma.,2021,10.18632/aging.202294,https://pubmed.ncbi.nlm.nih.gov/33495417/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,32021434,Circular RNA HIPK3 Promotes EMT of Cervical Cancer Through Sponging miR-338-3p to Up-Regulate HIF-1α.,2020,10.2147/cmar.s232235,https://pubmed.ncbi.nlm.nih.gov/32021434/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,37269429,CircHIPK3 negatively regulates autophagy by blocking VCP binding to the Beclin 1 complex in bladder cancer.,2023,10.1007/s12672-023-00689-0,https://pubmed.ncbi.nlm.nih.gov/37269429/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,30498360,The expression level and prognostic value of HIPK3 among non-small-cell lung cancer patients in China.,2018,10.2147/ott.s166878,https://pubmed.ncbi.nlm.nih.gov/30498360/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,31597523,Circular RNA HIPK3 induces cell proliferation and inhibits apoptosis in non-small cell lung cancer through sponging miR-149.,2020,10.1080/15384047.2019.1669995,https://pubmed.ncbi.nlm.nih.gov/31597523/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,33628038,CircHIPK3 Alleviates High Glucose Toxicity to Human Renal Tubular Epithelial HK-2 Cells Through Regulation of miR-326/miR-487a-3p/SIRT1.,2021,10.2147/dmso.s289624,https://pubmed.ncbi.nlm.nih.gov/33628038/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,29134957,Hunting for the mutant without the MAP(K).,2017,10.1038/cr.2017.140,https://pubmed.ncbi.nlm.nih.gov/29134957/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,29151587,Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models.,2017,10.1038/cr.2017.113,https://pubmed.ncbi.nlm.nih.gov/29151587/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,34326381,Kras-driven intratumoral heterogeneity triggers infiltration of M2 polarized macrophages via the circHIPK3/PTK2 immunosuppressive circuit.,2021,10.1038/s41598-021-94671-x,https://pubmed.ncbi.nlm.nih.gov/34326381/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,32550826,CircHIPK3 promotes proliferation and metastasis and inhibits apoptosis of renal cancer cells by inhibiting MiR-485-3p.,2020,10.1186/s12935-020-01319-3,https://pubmed.ncbi.nlm.nih.gov/32550826/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,27050392,Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs.,2016,10.1038/ncomms11215,https://pubmed.ncbi.nlm.nih.gov/27050392/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,31152681,"Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide.",2019,10.1002/1878-0261.12524,https://pubmed.ncbi.nlm.nih.gov/31152681/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,33402817,Silencing of circHIPK3 Inhibits Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction by Sponging miR-185-3p.,2020,10.2147/dddt.s245199,https://pubmed.ncbi.nlm.nih.gov/33402817/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,28779122,4β-Hydroxywithanolide E Modulates Alternative Splicing of Apoptotic Genes in Human Hepatocellular Carcinoma Huh-7 Cells.,2017,10.1038/s41598-017-07472-6,https://pubmed.ncbi.nlm.nih.gov/28779122/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,24586573,Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2).,2014,10.1371/journal.pone.0089176,https://pubmed.ncbi.nlm.nih.gov/24586573/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,11034606,FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation.,2000,10.1084/jem.192.8.1165,https://pubmed.ncbi.nlm.nih.gov/11034606/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,9725910,Activation of androgen receptor function by a novel nuclear protein kinase.,1998,10.1091/mbc.9.9.2527,https://pubmed.ncbi.nlm.nih.gov/9725910/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK3,ENSG00000110422,Unsafe,9373137,"Identification and sequence of human PKY, a putative kinase with increased expression in multidrug-resistant cells, with homology to yeast protein kinase Yak1.",1997,10.1016/s0378-1119(97)00350-8,https://pubmed.ncbi.nlm.nih.gov/9373137/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK4,ENSG00000160396,Unsafe,42597842,&lt;i&gt;HIPK4&lt;/i&gt; is a novel gene associated with teratozoospermia and male infertility.,2026,10.1093/hropen/hoag066,https://pubmed.ncbi.nlm.nih.gov/42597842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK4,ENSG00000160396,Unsafe,42837211,Small-Molecule Modulators of HIPK4 Activity and Proteostasis.,2026,10.1021/jacs.6c10097,https://pubmed.ncbi.nlm.nih.gov/42837211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK4,ENSG00000160396,Unsafe,42720483,Macrocyclization of Broad-Spectrum Kinase Inhibitor Bosutinib Leads to Potent and Selective Quinoline-Based HIPK4 Inhibitor AZ137.,2026,10.1021/acs.jmedchem.6c01320,https://pubmed.ncbi.nlm.nih.gov/42720483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK4,ENSG00000160396,Unsafe,40316017,HIPK4 accelerates cutaneous squamous cell carcinoma progression by phosphorylating TAp63 and inhibiting EFEMP1 expression.,2025,10.1016/j.jbc.2025.108564,https://pubmed.ncbi.nlm.nih.gov/40316017/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK4,ENSG00000160396,Unsafe,35931115,Homeodomain-interacting protein kinase HIPK4 regulates phosphorylation of manchette protein RIMBP3 during spermiogenesis.,2022,10.1016/j.jbc.2022.102327,https://pubmed.ncbi.nlm.nih.gov/35931115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK4,ENSG00000160396,Unsafe,32163033,HIPK4 is essential for murine spermiogenesis.,2020,10.7554/elife.50209,https://pubmed.ncbi.nlm.nih.gov/32163033/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK4,ENSG00000160396,Unsafe,37370521,"Evaluation of the Genetic Diversity, Population Structure and Selection Signatures of Three Native Chinese Pig Populations.",2023,10.3390/ani13122010,https://pubmed.ncbi.nlm.nih.gov/37370521/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK4,ENSG00000160396,Unsafe,28966120,An RNAi Screen Reveals an Essential Role for HIPK4 in Human Skin Epithelial Differentiation from iPSCs.,2017,10.1016/j.stemcr.2017.08.023,https://pubmed.ncbi.nlm.nih.gov/28966120/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK4,ENSG00000160396,Unsafe,31228193,Genetic cooperativity in multi-layer networks implicates cell survival and senescence in the striatum of Huntington's disease mice synchronous to symptoms.,2020,10.1093/bioinformatics/btz514,https://pubmed.ncbi.nlm.nih.gov/31228193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK4,ENSG00000160396,Unsafe,25630557,Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).,2015,10.1186/s12964-014-0082-6,https://pubmed.ncbi.nlm.nih.gov/25630557/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK4,ENSG00000160396,Unsafe,20508833,Characterization of Human Homeodomain-interacting Protein Kinase 4 (HIPK4) as a Unique Member of the HIPK Family.,2010,,https://pubmed.ncbi.nlm.nih.gov/20508833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK4,ENSG00000160396,Unsafe,27632927,Genome-wide association analysis reveals variants on chromosome 19 that contribute to childhood risk of chronic otitis media with effusion.,2016,10.1038/srep33240,https://pubmed.ncbi.nlm.nih.gov/27632927/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK4,ENSG00000160396,Unsafe,18022393,"Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9.",2007,10.1016/j.febslet.2007.11.022,https://pubmed.ncbi.nlm.nih.gov/18022393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK4,ENSG00000160396,Unsafe,24225127,Integration of stress signals by homeodomain interacting protein kinases.,2014,10.1515/hsz-2013-0264,https://pubmed.ncbi.nlm.nih.gov/24225127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HIPK4,ENSG00000160396,Unsafe,30602479,Male Contraceptive Development: Update on Novel Hormonal and Nonhormonal Methods.,2019,10.1373/clinchem.2018.295089,https://pubmed.ncbi.nlm.nih.gov/30602479/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,42321518,"HJURP upregulation, driven by transcription factor NFYA, promotes endometrial carcinoma progression via regulating RASSF8 ubiquitination.",2026,10.1007/s10142-026-01904-1,https://pubmed.ncbi.nlm.nih.gov/42321518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,42456538,tRNA-derived fragment AS-tDR-008272 promotes NSCLC tumorigenesis by propelling glycolytic metabolism via regulating HJURP.,2026,10.1016/j.tranon.2026.102908,https://pubmed.ncbi.nlm.nih.gov/42456538/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,42384816,Remote homology and functional genetics unmask deeply preserved Scm3/HJURP orthologs in metazoans.,2026,10.1126/sciadv.aeg5356,https://pubmed.ncbi.nlm.nih.gov/42384816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,41180845,Unveiling HJURP as a Biomarker of Poor Prognosis and Immunotherapy Resistance in Lung Adenocarcinoma: A Multicenter Study.,2025,10.1177/11795549251388872,https://pubmed.ncbi.nlm.nih.gov/41180845/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,41507393,Dual pathways via CENP-C and Mis18C recruit HJURP for CENP-A deposition into vertebrate centromeres.,2026,10.1038/s44318-025-00674-z,https://pubmed.ncbi.nlm.nih.gov/41507393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,42635181,Dual Roads of CENP-A for Centromere Identification.,2026,10.1002/bies.70177,https://pubmed.ncbi.nlm.nih.gov/42635181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,40290723,HJURP modulates cell proliferation and chemoresistance via the MYC/TOP2A transcriptional axis in gastric cancer.,2025,10.3389/fmolb.2025.1566293,https://pubmed.ncbi.nlm.nih.gov/40290723/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,42715337,The CENP-A chaperone complex spatially organizes centromeres.,2026,10.1126/sciadv.aef1579,https://pubmed.ncbi.nlm.nih.gov/42715337/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,42080449,Dysregulation of microRNAs and Centromere Protein Genes in Prostate Cancer and Metastatic Progression.,2026,10.5152/tud.2026.26143,https://pubmed.ncbi.nlm.nih.gov/42080449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,37958340,The Clinical Impact of Death Domain-Associated Protein and Holliday Junction Recognition Protein Expression in Cancer: Unmasking the Driving Forces of Neoplasia.,2023,10.3390/cancers15215165,https://pubmed.ncbi.nlm.nih.gov/37958340/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,39649097,"Holliday junction recognition protein (HJURP) could reflect the clinical outcomes of lung adenocarcinoma patients, and impact the choice of precision therapy.",2024,10.3389/fgene.2024.1475511,https://pubmed.ncbi.nlm.nih.gov/39649097/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,39736453,Oncogenic HJURP enhancer promotes the aggressive behavior of triple-negative breast cancer in association with p53/E2F1/FOXM1-axis.,2025,10.1016/j.canlet.2024.217423,https://pubmed.ncbi.nlm.nih.gov/39736453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,41681894,Comprehensive Characterization of Stem Cell Landscape Identifies Novel Stemness-Relevant Genes for Nasopharyngeal Carcinoma Therapy.,2026,10.3390/cancers18030422,https://pubmed.ncbi.nlm.nih.gov/41681894/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,39725623,[Holliday junction-recognizing protein is a potential predictive and prognostic biomarker for kidney renal clear cell carcinoma].,2024,10.12122/j.issn.1673-4254.2024.12.10,https://pubmed.ncbi.nlm.nih.gov/39725623/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,42236945,Centromeric footprints preserve telomere integrity in ALT cancers.,2026,10.1038/s41586-026-10598-1,https://pubmed.ncbi.nlm.nih.gov/42236945/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,41007424,Ferroptosis-Linked Six-Gene Panel Enables Machine Learning-Assisted Diagnosis and Therapeutic Guidance in Lung Adenocarcinoma.,2025,10.3390/biology14091280,https://pubmed.ncbi.nlm.nih.gov/41007424/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,41629527,M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans.,2026,10.1038/s44318-026-00698-z,https://pubmed.ncbi.nlm.nih.gov/41629527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,39405980,HJURP inhibits sensitivity to ferroptosis inducers in prostate cancer cells by enhancing the peroxidase activity of PRDX1.,2024,10.1016/j.redox.2024.103392,https://pubmed.ncbi.nlm.nih.gov/39405980/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,41370334,Evidence of centromeric histone 3 chaperone involved in DNA damage repair pathway in budding yeast.,2025,10.7554/elife.104431,https://pubmed.ncbi.nlm.nih.gov/41370334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,38561384,Identification of ASF1A and HJURP by global H3-H4 histone chaperone analysis as a prognostic two-gene model in hepatocellular carcinoma.,2024,10.1038/s41598-024-58368-1,https://pubmed.ncbi.nlm.nih.gov/38561384/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,40660314,Kinesin-related genes stratified the prognosis and immune responses of clear cell renal cell carcinoma.,2025,10.1186/s40001-025-02880-1,https://pubmed.ncbi.nlm.nih.gov/40660314/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,40299539,A Senescence-Associated Gene Signature for Prognostic Prediction and Therapeutic Targeting in Adrenocortical Carcinoma.,2025,10.3390/biomedicines13040894,https://pubmed.ncbi.nlm.nih.gov/40299539/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,40592939,Identification of novel gene-based risk score for prognosis in prostate cancer.,2025,10.1038/s41598-025-03800-3,https://pubmed.ncbi.nlm.nih.gov/40592939/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,35783358,Holliday Cross-Recognition Protein HJURP: Association With the Tumor Microenvironment in Hepatocellular Carcinoma and With Patient Prognosis.,2022,10.3389/pore.2022.1610506,https://pubmed.ncbi.nlm.nih.gov/35783358/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,38124367,Identification of novel potential homologous repair deficiency-associated genes in pancreatic adenocarcinoma via WGCNA coexpression network analysis and machine learning.,2023,10.1080/15384101.2023.2293594,https://pubmed.ncbi.nlm.nih.gov/38124367/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,33235818,Anti-cancer immunotherapy using cancer-derived multiple epitope-peptides cocktail vaccination clinical studies in patients with refractory/persistent disease of uterine cervical cancer and ovarian cancer [phase 2].,2020,10.1080/2162402x.2020.1838189,https://pubmed.ncbi.nlm.nih.gov/33235818/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,36460821,Pan-cancer analysis based on epigenetic modification explains the value of HJURP in the tumor microenvironment.,2022,10.1038/s41598-022-25439-0,https://pubmed.ncbi.nlm.nih.gov/36460821/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,38084929,The cysteine-rich domain in CENP-A chaperone Scm3HJURP ensures centromere targeting and kinetochore integrity.,2024,10.1093/nar/gkad1182,https://pubmed.ncbi.nlm.nih.gov/38084929/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,37025176,"Advances in holliday junction recognition protein (HJURP): Structure, molecular functions, and roles in cancer.",2023,10.3389/fcell.2023.1106638,https://pubmed.ncbi.nlm.nih.gov/37025176/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,40251374,Construction of a prognostic model and identification of key genes in liver hepatocellular carcinoma based on multi-omics data.,2025,10.1038/s41598-025-98038-4,https://pubmed.ncbi.nlm.nih.gov/40251374/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,17823411,Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells.,2007,10.1158/0008-5472.can-07-1307,https://pubmed.ncbi.nlm.nih.gov/17823411/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HJURP,ENSG00000123485,Unsafe,17256767,Identification of FAKTS as a novel 14-3-3-associated nuclear protein.,2007,10.1002/prot.21288,https://pubmed.ncbi.nlm.nih.gov/17256767/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42180941,Prognostic value and therapeutic implications of HMGA2 in EGFR-mutant non-small cell lung cancer.,2026,10.21037/tcr-2025-aw-2371,https://pubmed.ncbi.nlm.nih.gov/42180941/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42807219,Associations of &lt;i&gt;HMGA2&lt;/i&gt; single-nucleotide polymorphisms with clinicopathological features of tongue squamous cell carcinoma in Taiwanese men with distinct lifestyle-related risk factors.,2026,10.7150/jca.139096,https://pubmed.ncbi.nlm.nih.gov/42807219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42910299,HMGA2 Stabilizes hnRNPK to Drive YAP-Dependent Liver Metastasis in Pancreatic Cancer.,2026,10.7150/ijbs.133139,https://pubmed.ncbi.nlm.nih.gov/42910299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42369036,&lt;i&gt;HMGA2&lt;/i&gt; regulates fear and growth: Canine GWAS and functional evidence.,2026,10.1016/j.isci.2026.116429,https://pubmed.ncbi.nlm.nih.gov/42369036/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42190867,Hmga2-dependent cAMP signaling drives UVB-induced melanocyte stem cell activation.,2026,10.1016/j.jid.2026.05.007,https://pubmed.ncbi.nlm.nih.gov/42190867/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42869161,LncRNA SNHG4 sponges miR-let-7d-5p to drive rare earth-induced pulmonary epithelial-mesenchymal transition via HMGA2.,2026,10.1016/j.cbi.2026.112381,https://pubmed.ncbi.nlm.nih.gov/42869161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,41516076,AI/ML-Assisted Detection of &lt;i&gt;HMGA2&lt;/i&gt; RNA Isoforms in Prostate Cancer Patient Tissue.,2025,10.3390/ijms27010196,https://pubmed.ncbi.nlm.nih.gov/41516076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42342150,IGF2BP1-Mediated m⁶A Modification Stabilizes HMGA2 mRNA to Promote Intrahepatic Cholangiocarcinoma Progression.,2026,10.1016/j.jcmgh.2026.101837,https://pubmed.ncbi.nlm.nih.gov/42342150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42716196,Houshiheisan modulates angiogenic responses after ischemic stroke in association with miR-126/PIK3R2 and miR-21/Hmga2/WWP1 signaling.,2026,10.1016/j.jep.2026.122371,https://pubmed.ncbi.nlm.nih.gov/42716196/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42583679,HMGA2 is a highly sensitive marker for DICER1-related tumours.,2026,10.1111/his.70255,https://pubmed.ncbi.nlm.nih.gov/42583679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42068395,Emerging roles for SNRPB2 in governing the cell cycle and steering tumor immune modulation in breast cancer.,2026,10.1007/s11033-026-11874-z,https://pubmed.ncbi.nlm.nih.gov/42068395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,40518465,High mobility group protein 2 (HMGA2) is highly expressed in a broad range of benign and malignant tumors.,2025,10.1007/s00428-025-04142-1,https://pubmed.ncbi.nlm.nih.gov/40518465/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42151936,LncRNA HMGA2-AS1 promotes postoperative recurrence in non-muscle-invasive bladder cancer by sponging miR-367-3p to activate YAP1.,2026,10.1186/s12957-026-04391-7,https://pubmed.ncbi.nlm.nih.gov/42151936/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42169592,HMGA2 Overexpression Is Associated with Poor Prognosis and EGFR Signaling Activation in Oral Squamous Cell Carcinoma.,2026,10.31557/apjcp.2026.27.5.1855,https://pubmed.ncbi.nlm.nih.gov/42169592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42908240,The Largest Cohort Study of Intravenous Leiomyomatosis Reveals HMGA2 and Collagen Gene Alterations as Cooperative Drivers.,2026,10.1097/pas.0000000000002637,https://pubmed.ncbi.nlm.nih.gov/42908240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42589587,Inhibition of the AT-Hook DNA-Binding Domain Attenuates HMGA2-Mediated Epithelial Mesenchyme Transition in Esophageal Cancer Cells.,2026,10.3390/ijms27156933,https://pubmed.ncbi.nlm.nih.gov/42589587/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42265324,HMGA2 identified via m6A-senescence multi-omics in laryngeal squamous cell carcinoma.,2026,10.1038/s41598-026-55980-1,https://pubmed.ncbi.nlm.nih.gov/42265324/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42801071,HMGA2-Rearranged Lipoblastoma in an Adult Patient With Novel GRIP1 Gene Fusion Partner.,2026,10.7759/cureus.115291,https://pubmed.ncbi.nlm.nih.gov/42801071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42745033,SMC1A is required for fate determinations of human spermatogonial stem cells and male fertility by interacting with YBX1 and stabilizing HMGA2 mRNA via an m&lt;sup&gt;5&lt;/sup&gt;C modification.,2026,10.1038/s41418-026-01872-w,https://pubmed.ncbi.nlm.nih.gov/42745033/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,41817622,Proteomic analysis reveals the pro-proliferative role of the LIN28B/HMGA2 axis in hepatoblastoma.,2026,10.1007/s00383-026-06385-8,https://pubmed.ncbi.nlm.nih.gov/41817622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,41290257,HMGA2 links morphological evolution and microenvironment dynamics to systemic therapy response in clear cell renal cell carcinoma.,2025,10.1136/jitc-2025-012568,https://pubmed.ncbi.nlm.nih.gov/41290257/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,40703517,Prognostic significance and immune infiltration analysis of HMGA2 in endometrial cancer.,2025,10.3389/fimmu.2025.1559278,https://pubmed.ncbi.nlm.nih.gov/40703517/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42444878,Integrated hypoxia and metabolic gene signature to predict clinical outcomes and therapeutic vulnerabilities in lung adenocarcinoma.,2026,10.21037/jtd-2026-1370,https://pubmed.ncbi.nlm.nih.gov/42444878/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42220428,The Role of HPV and Hormone in Cervical Precancer and Cancer: Molecular Pathophysiology and Cell Biology of Disease and Treatment.,2026,10.32604/or.2026.078219,https://pubmed.ncbi.nlm.nih.gov/42220428/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,41319578,Waterpipe Smoke-Induced N6-Methyladenosine Modification Promotes the Progression of Oral Squamous Cell Carcinoma.,2026,10.1016/j.identj.2025.109295,https://pubmed.ncbi.nlm.nih.gov/41319578/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,41713747,Posaconazole attenuates arsenic trioxide toxicity and enhances safety and efficacy while reducing invasion and metastasis in non-small-cell lung cancer.,2026,10.1016/j.pupt.2026.102412,https://pubmed.ncbi.nlm.nih.gov/41713747/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,40626038,The Role of EZH2 in Initiating Epigenetic Regulation of CRSwNP.,2025,10.2147/jir.s525688,https://pubmed.ncbi.nlm.nih.gov/40626038/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,41469334,Single-nucleus RNA sequencing reveals the distinct heterogeneity of primary pulmonary sarcomas (PPS) and pulmonary sarcomatoid carcinoma (PSC).,2026,10.1002/ctm2.70566,https://pubmed.ncbi.nlm.nih.gov/41469334/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,41964890,Single-cell RNA sequencing reveals HMGA2 involvement in neoplastic aggressiveness and endothelial cell senescence in chondrosarcoma.,2026,10.1007/s10565-026-10188-x,https://pubmed.ncbi.nlm.nih.gov/41964890/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42104168,Leveraging mitochondrial dynamics-related risk signatures to predict the prognosis and tumor microenvironment of lung adenocarcinoma.,2026,10.1007/s12672-026-05038-5,https://pubmed.ncbi.nlm.nih.gov/42104168/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,42519790,"Locus-specific HERV expression identifies an aggressive, NK-depleted, checkpoint-refractory acral melanoma phenotype.",2026,10.3389/fmed.2026.1834744,https://pubmed.ncbi.nlm.nih.gov/42519790/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,41818173,Keratin-Positive Giant Cell-Rich Tumor in Early Infancy: Metastatic Presentation and Imatinib Response.,2026,10.1097/mph.0000000000003177,https://pubmed.ncbi.nlm.nih.gov/41818173/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,40884260,Single-Cell Transcriptome Analysis Reveals That Hmga2 Regulates Neuroinflammation and Retinal Function by Modulating Müller Cell Autophagy Through PI3K/AKT Signaling Following MCAO-Induced Retinal Ischemia.,2025,10.1002/advs.202502534,https://pubmed.ncbi.nlm.nih.gov/40884260/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,40686969,Integrating Multiomics and Machine Learning: Senescence-Regulated ALMS1-IT1/miR-7c-5p/HMGA2 Axis as a Novel Therapeutic Target for Head and Neck Squamous Cell Carcinoma.,2025,10.1021/acsomega.4c11093,https://pubmed.ncbi.nlm.nih.gov/40686969/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGA2,ENSG00000149948,Unsafe,39680021,"HMGA2 Expression Predicts Subtype, Survival, and Treatment Outcome in Pancreatic Ductal Adenocarcinoma.",2025,10.1158/1078-0432.ccr-24-2200,https://pubmed.ncbi.nlm.nih.gov/39680021/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,42310973,Expression and Survival Analysis Show High Mobility Group (HMG) Family as Prognostic Biomarkers in Breast Cancer.,2026,10.4274/ejbh.galenos.2025.2025-10-10,https://pubmed.ncbi.nlm.nih.gov/42310973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,42748838,Protamine gene expression is associated with sperm motility in rams: An integrative experimental and gene network analysis.,2026,10.1016/j.anireprosci.2026.108317,https://pubmed.ncbi.nlm.nih.gov/42748838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,40649876,Age-Associated Proteomic Changes in Human Spermatozoa.,2025,10.3390/ijms26136099,https://pubmed.ncbi.nlm.nih.gov/40649876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,38731262,Single-Cell Transcriptome Sequencing Reveals Molecular Expression Differences and Marker Genes in Testes during the Sexual Maturation of Mongolian Horses.,2024,10.3390/ani14091258,https://pubmed.ncbi.nlm.nih.gov/38731262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,36446526,Transcriptome analyses in infertile men reveal germ cell-specific expression and splicing patterns.,2023,10.26508/lsa.202201633,https://pubmed.ncbi.nlm.nih.gov/36446526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,41706575,ChIP-MS in Plant Systems: Mapping the H3K27ac Proteome During the Greening Process.,2026,10.1111/ppl.70797,https://pubmed.ncbi.nlm.nih.gov/41706575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,40646788,"Genetic Parameters, Linear Associations, and Genome-Wide Association Study for Endotoxin-Induced Cortisol Response in &lt;i&gt;Holstein heifers&lt;/i&gt;.",2025,10.3390/ani15131890,https://pubmed.ncbi.nlm.nih.gov/40646788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,39961484,Comparative proteomics and phosphoproteomics analysis reveals differential sperm motility in Mediterranean buffalo semen.,2025,10.1016/j.jprot.2025.105401,https://pubmed.ncbi.nlm.nih.gov/39961484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,33428061,The role of high mobility group protein B3 (HMGB3) in tumor proliferation and drug resistance.,2021,10.1007/s11010-020-04015-y,https://pubmed.ncbi.nlm.nih.gov/33428061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,27608812,HMGB4 is expressed by neuronal cells and affects the expression of genes involved in neural differentiation.,2016,10.1038/srep32960,https://pubmed.ncbi.nlm.nih.gov/27608812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,28096358,Repair shielding of platinum-DNA lesions in testicular germ cell tumors by high-mobility group box protein 4 imparts cisplatin hypersensitivity.,2017,10.1073/pnas.1615327114,https://pubmed.ncbi.nlm.nih.gov/28096358/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,36105089,An integrative analysis of DNA methylation and gene expression to predict lung adenocarcinoma prognosis.,2022,10.3389/fgene.2022.970507,https://pubmed.ncbi.nlm.nih.gov/36105089/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,22901013,Binding interaction of HMGB4 with cisplatin-modified DNA.,2012,10.1021/bi300649v,https://pubmed.ncbi.nlm.nih.gov/22901013/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,18987332,"HMGB4, a novel member of the HMGB family, is preferentially expressed in the mouse testis and localizes to the basal pole of elongating spermatids.",2009,10.1095/biolreprod.108.070243,https://pubmed.ncbi.nlm.nih.gov/18987332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,33069132,RNA-Seq analysis reveals functionally relevant coding and non-coding RNAs in crossbred bull spermatozoa.,2020,10.1016/j.anireprosci.2020.106621,https://pubmed.ncbi.nlm.nih.gov/33069132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,25609838,Combining RNA and protein profiling data with network interactions identifies genes associated with spermatogenesis in mouse and human.,2015,10.1095/biolreprod.114.126250,https://pubmed.ncbi.nlm.nih.gov/25609838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,30616326,[Clinical application of high mobility group box nuclear protein 1 subcomponent in the progression of liver cancer].,2018,10.3760/cma.j.issn.1007-3418.2018.11.014,https://pubmed.ncbi.nlm.nih.gov/30616326/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,22655796,High-mobility group boxes mediate cell proliferation and radiosensitivity via retinoblastoma-interaction-dependent and -independent mechanisms.,2012,10.1089/cbr.2012.1199,https://pubmed.ncbi.nlm.nih.gov/22655796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMGB4,ENSG00000176256,Unsafe,17169924,"Characterization of transgenic Arabidopsis plants overexpressing high mobility group B proteins under high salinity, drought or cold stress.",2007,10.1093/pcp/pcl057,https://pubmed.ncbi.nlm.nih.gov/17169924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMHB1,ENSG00000158497,Unsafe,9892612,A human minor histocompatibility antigen specific for B cell acute lymphoblastic leukemia.,1999,10.1084/jem.189.2.301,https://pubmed.ncbi.nlm.nih.gov/9892612/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMHB1,ENSG00000158497,Unsafe,8992968,Recognition of a B cell leukemia-associated minor histocompatibility antigen by CTL.,1997,10.4049/jimmunol.158.2.560,https://pubmed.ncbi.nlm.nih.gov/8992968/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,42789195,"Expression of long non‑coding RNAs DIAPH3‑AS1, HMMR‑AS1, and SPATA3‑AS1 in patients with colorectal cancer: association with chemotherapy response and clinicopathological features.",2026,10.1007/s11033-026-12789-5,https://pubmed.ncbi.nlm.nih.gov/42789195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,41254645,HMMR in human cancers: regulatory mechanism and biological function.,2025,10.1186/s12967-025-07260-1,https://pubmed.ncbi.nlm.nih.gov/41254645/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,42706229,HMMR&lt;sup&gt;+&lt;/sup&gt; stromal cells drive human uterine development.,2026,10.1038/s41421-026-00921-5,https://pubmed.ncbi.nlm.nih.gov/42706229/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,42908476,Hyaluronan-Mediated Motility Receptor Potentiates Colorectal Carcinoma Progression Through PI3K/AKT/mTOR Pathway Modulation.,2026,10.1111/ajco.70200,https://pubmed.ncbi.nlm.nih.gov/42908476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,42748147,RHAMM drives formation of polyploid cancer cells and confers resistance to ER-targeted therapy in breast cancer.,2026,10.1073/pnas.2535342123,https://pubmed.ncbi.nlm.nih.gov/42748147/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,42741478,Hmmr&lt;sup&gt;+&lt;/sup&gt; Fibroblasts Facilitate Hair Regeneration by Biomechanical Sensing of Extracellular Matrix Viscoelasticity.,2026,10.34133/research.1430,https://pubmed.ncbi.nlm.nih.gov/42741478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,40661163,The truncated isoform of the receptor for hyaluronan-mediated motility (RHAMM&lt;sup&gt;Δ163&lt;/sup&gt;) modulates shelterin and telomerase reverse transcriptase transcription affecting telomerase activity.,2025,10.3389/fragi.2025.1604051,https://pubmed.ncbi.nlm.nih.gov/40661163/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,42142272,Mechanism analysis of transgene expression induced by chitosan/hyaluronic acid nanoparticles in CD44v9/RHAMM co-expressed gastric cancer cells: contribution of hyaluronic acid to RHAMM-mediated intracellular transport.,2026,10.1007/s10719-026-10218-0,https://pubmed.ncbi.nlm.nih.gov/42142272/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,42326385,HMMR as a robust prognostic biomarker correlates with immune infiltration and cell cycle pathways in oral squamous cell carcinoma: a multi-cohort bioinformatics analysis based on TCGA and GEO databases.,2026,10.3389/fgene.2026.1764943,https://pubmed.ncbi.nlm.nih.gov/42326385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,42555355,A pontine-specific niche supports de novo gliomagenesis.,2026,10.1016/j.celrep.2026.117796,https://pubmed.ncbi.nlm.nih.gov/42555355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,41168860,Hyaluronan-mediated motility receptor regulating the Wnt/β-catenin signaling resulting in hepatocellular carcinoma by inhibiting the phosphorylation activity of GSK-3β.,2025,10.1186/s40001-025-03372-y,https://pubmed.ncbi.nlm.nih.gov/41168860/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,41550726,HMMR/RHAMM recruits SACK1D/FAM83D-CK1α complex at the mitotic spindle to control spindle alignment.,2026,10.1016/j.isci.2025.114417,https://pubmed.ncbi.nlm.nih.gov/41550726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,42021279,ASPM promotes the progression of esophageal squamous cell carcinoma by upregulating the expression of HMMR.,2026,10.1186/s12935-026-04300-8,https://pubmed.ncbi.nlm.nih.gov/42021279/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,41253884,HMMR has oncoprotein-like properties in neuroblastoma cells and high HMMR expression has independent prognostic potential in neuroblastomas.,2025,10.1038/s41598-025-23141-5,https://pubmed.ncbi.nlm.nih.gov/41253884/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,42860388,Epigenetic Silencing of CYYR1 Promotes Lung Adenocarcinoma Progression Through TRIM21-Dependent Regulation of HMMR Stability.,2026,10.1002/advs.77890,https://pubmed.ncbi.nlm.nih.gov/42860388/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,42605368,Screening of Metabolic Reprogramming-Related Diagnostic Biomarkers and Analysis of Immune Heterogeneity in Atopic Dermatitis Based on Multi-Cohort Validation.,2026,10.2147/ccid.s622509,https://pubmed.ncbi.nlm.nih.gov/42605368/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,41083782,HMMR mediates progression of nasopharyngeal carcinoma by inhibiting FAM83D ubiquitination and activating beta-catenin signaling pathway.,2025,10.1038/s41598-025-19641-z,https://pubmed.ncbi.nlm.nih.gov/41083782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,41301516,"A Novel Role of Hyaluronan and Its Membrane Receptors, CD44 and RHAMM, in Obesity-Related Kidney Pathology.",2025,10.3390/biom15111598,https://pubmed.ncbi.nlm.nih.gov/41301516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,42389755,The myofascial rheostat: hyaluronan molecular weight dynamics and purinergic signalling as a physiological feedback system.,2026,10.3389/fphys.2026.1854585,https://pubmed.ncbi.nlm.nih.gov/42389755/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,40806330,"Targeting RHAMM in Cancer: Crosstalk with Non-Coding RNAs and Emerging Therapeutic Strategies Including Peptides, Oligomers, Antibodies, and Vaccines.",2025,10.3390/ijms26157198,https://pubmed.ncbi.nlm.nih.gov/40806330/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,42551718,An oxidative stress - and immunotherapy-related six-gene signature defines immune subtypes and predicts prognosis and immunotherapy response in hepatocellular carcinoma.,2026,10.1016/j.gene.2026.150335,https://pubmed.ncbi.nlm.nih.gov/42551718/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,39698582,Identification of BIRC5 and HMMR as prognostic biomarkers for immune infiltration in prostate cancer.,2024,10.21037/tau-24-359,https://pubmed.ncbi.nlm.nih.gov/39698582/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,40612677,Decoding the Tumor Microenvironment: Exosome-Mediated Macrophage Polarization and Therapeutic Frontiers.,2025,10.7150/ijbs.114222,https://pubmed.ncbi.nlm.nih.gov/40612677/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,39789627,miR-9-5p/HMMR regulates the tumorigenesis and progression of clear cell renal cell carcinoma through EMT and JAK1/STAT1 signaling pathway.,2025,10.1186/s12967-024-05988-w,https://pubmed.ncbi.nlm.nih.gov/39789627/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,41488674,PSMD14 drives lung adenocarcinoma progression through HMMR stabilization and dual activation of TGF-β/Smad and PI3K/AKT/mTOR signaling.,2025,10.3389/fimmu.2025.1720799,https://pubmed.ncbi.nlm.nih.gov/41488674/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,42724831,A model of cellular proliferation and mitochondrial biogenesis predicts prognosis and immunotherapy response in lung adenocarcinoma.,2026,10.21037/tcr-2025-1-2721,https://pubmed.ncbi.nlm.nih.gov/42724831/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,41155434,"Hyaluronic Acid in Liver Fibrosis: Role in Inflammation, Tissue Remodeling, and Disease Progression.",2025,10.3390/ijms262010139,https://pubmed.ncbi.nlm.nih.gov/41155434/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,41234898,Integrative single-cell and bulk transcriptomes analyses reveal T cell-related prognostic risk model and tumor immune microenvironment modulation in colorectal cancer.,2025,10.21037/tcr-2025-1104,https://pubmed.ncbi.nlm.nih.gov/41234898/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,38633247,Coupled scRNA-seq and Bulk-seq reveal the role of HMMR in hepatocellular carcinoma.,2024,10.3389/fimmu.2024.1363834,https://pubmed.ncbi.nlm.nih.gov/38633247/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,41948730,Hyaluronic acid: emerging roles and biomaterial innovations in Alzheimer's and Parkinson's disease therapy.,2026,10.3389/fphar.2026.1772172,https://pubmed.ncbi.nlm.nih.gov/41948730/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,41613804,Esketamine Enhances the Chemosensitivity of Colorectal Adenocarcinoma Cells to 5-Fluorouracil via AMPK/mTOR/HMMR Signaling Pathway.,2026,10.32604/or.2025.072563,https://pubmed.ncbi.nlm.nih.gov/41613804/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,40824331,Identification of glycolysis-related molecular subtypes and prognostic model in intrahepatic cholangiocarcinoma.,2025,10.1007/s12672-025-03314-4,https://pubmed.ncbi.nlm.nih.gov/40824331/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,42329455,Identification of circadian rhythm-associated key genes in metabolic dysfunction-associated fatty liver disease.,2026,10.1007/s10238-026-02234-z,https://pubmed.ncbi.nlm.nih.gov/42329455/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,39692931,Identification of potential biomarkers for hepatocellular carcinoma based on machine learning and bioinformatics analysis.,2024,10.1007/s12672-024-01667-w,https://pubmed.ncbi.nlm.nih.gov/39692931/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,22965910,Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation.,2012,10.1083/jcb.201202112,https://pubmed.ncbi.nlm.nih.gov/22965910/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HMMR,ENSG00000072571,Unsafe,8890751,The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains.,1996,10.1016/0378-1119(96)00080-7,https://pubmed.ncbi.nlm.nih.gov/8890751/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,41526502,A comprehensive study integrating bioinformatics analysis and experimental results on HROB as a potential biomarker for the prognosis of lung adenocarcinoma.,2026,10.1038/s41598-026-35798-7,https://pubmed.ncbi.nlm.nih.gov/41526502/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,41184881,HROB is a novel prognostic biomarker correlated with immune cell infiltration and tumor progression in lung adenocarcinoma.,2025,10.1186/s12957-025-04070-z,https://pubmed.ncbi.nlm.nih.gov/41184881/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,41878782,Biallelic Germline Inactivation of HROB Causes Primary Gonadal Insufficiency and is Potentially Associated with Colonic Polyposis Predisposition.,2026,10.1002/ajmg.a.70128,https://pubmed.ncbi.nlm.nih.gov/41878782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,40654113,HROB Induces Lung Adenocarcinoma Progression via ZC3HC1-CCNB1 Axis Regulation and Cell Cycle Dysregulation.,2025,10.1111/cas.70141,https://pubmed.ncbi.nlm.nih.gov/40654113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,39766854,HROB Is Implicated in DNA Replication.,2024,10.3390/genes15121587,https://pubmed.ncbi.nlm.nih.gov/39766854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,38678026,Mechanism of DNA unwinding by MCM8-9 in complex with HROB.,2024,10.1038/s41467-024-47936-8,https://pubmed.ncbi.nlm.nih.gov/38678026/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,41237481,MCM8/9 and FANCD2 interact within a shared pathway in response to replication stress caused by DNA crosslinks.,2025,10.1016/j.dnarep.2025.103909,https://pubmed.ncbi.nlm.nih.gov/41237481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,38600407,Long-term quality of life after hybrid robot-assisted and open Ivor Lewis esophagectomy for esophageal cancer in a single center: a comparative analysis.,2024,10.1007/s00423-024-03310-2,https://pubmed.ncbi.nlm.nih.gov/38600407/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,35903352,Pan-Cancer Analysis Identified Homologous Recombination Factor With OB-Fold (HROB) as a Potential Biomarker for Various Tumor Types.,2022,10.3389/fgene.2022.904060,https://pubmed.ncbi.nlm.nih.gov/35903352/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,42456411,"5-Fluorouracil loaded copper‑aluminum layered double hydroxides inhibit colorectal cancer cells by inducing oxidative stress, mitochondrial membrane depolarization, apoptosis, and cell cycle arrest.",2026,10.1016/j.bioorg.2026.110241,https://pubmed.ncbi.nlm.nih.gov/42456411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,36470143,Identification and analysis of C17orf53 as a prognostic signature for hepatocellular carcinoma.,2023,10.1016/j.compbiomed.2022.106348,https://pubmed.ncbi.nlm.nih.gov/36470143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,36099812,Genetic landscape of a large cohort of Primary Ovarian Insufficiency: New genes and pathways and implications for personalized medicine.,2022,10.1016/j.ebiom.2022.104246,https://pubmed.ncbi.nlm.nih.gov/36099812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,34707299,Meiotic genes in premature ovarian insufficiency: variants in HROB and REC8 as likely genetic causes.,2022,10.1038/s41431-021-00977-9,https://pubmed.ncbi.nlm.nih.gov/34707299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,32853826,C17orf53 is identified as a novel gene involved in inter-strand crosslink repair.,2020,10.1016/j.dnarep.2020.102946,https://pubmed.ncbi.nlm.nih.gov/32853826/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,36344674,Low-molecular-weight cyclin E deregulates DNA replication and damage repair to promote genomic instability in breast cancer.,2022,10.1038/s41388-022-02527-z,https://pubmed.ncbi.nlm.nih.gov/36344674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,31575675,"Ways to unwind with HROB, a new player in homologous recombination.",2019,10.1101/gad.331850.119,https://pubmed.ncbi.nlm.nih.gov/31575675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,37535404,Structural and mechanistic insights into the MCM8/9 helicase complex.,2023,10.7554/elife.87468,https://pubmed.ncbi.nlm.nih.gov/37535404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,30370607,Why SNP rs227584 is associated with human BMD and fracture risk? A molecular and cellular study in bone cells.,2019,10.1111/jcmm.13991,https://pubmed.ncbi.nlm.nih.gov/30370607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,32528060,MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage.,2020,10.1038/s41467-020-16718-3,https://pubmed.ncbi.nlm.nih.gov/32528060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,31713854,The impact of the Medicaid high-risk ob care management program in New York State.,2020,10.1111/1475-6773.13236,https://pubmed.ncbi.nlm.nih.gov/31713854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,37207675,Factors Associated with Guideline Concordant Clinician Counseling about Low-Dose Aspirin to Prevent Preeclampsia in Nulliparous Patients.,2024,10.1055/a-2096-3466,https://pubmed.ncbi.nlm.nih.gov/37207675/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HROB,ENSG00000125319,Unsafe,24921060,Maternal differences and birth outcome disparities: Diversity within a high risk prenatal clinic.,2014,10.1007/s40615-013-0002-2,https://pubmed.ncbi.nlm.nih.gov/24921060/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,42101182,Expression of sulfate pathway genes in human neurodevelopment.,2026,10.1080/01677063.2026.2649162,https://pubmed.ncbi.nlm.nih.gov/42101182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,41162332,Differential Impact of BMI-Associated Genetic Variants on Breast Cancer Risk: Insights From Mediation Analysis.,2026,10.1111/cas.70239,https://pubmed.ncbi.nlm.nih.gov/41162332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,40018519,Deciphering novel mitochondrial signatures: multi-omics analysis uncovers cross-disease markers and oligodendrocyte pathways in Alzheimer's disease and glioblastoma.,2025,10.3389/fnagi.2025.1536142,https://pubmed.ncbi.nlm.nih.gov/40018519/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,39079175,Genome wide association study of clinical duration and age at onset of sporadic CJD.,2024,10.1371/journal.pone.0304528,https://pubmed.ncbi.nlm.nih.gov/39079175/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,37107618,Genomic Regions Associated with Milk Composition and Fertility Traits in Spring-Calved Dairy Cows in New Zealand.,2023,10.3390/genes14040860,https://pubmed.ncbi.nlm.nih.gov/37107618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,28017727,Silencing HS6ST3 inhibits growth and progression of breast cancer cells through suppressing IGF1R and inducing XAF1.,2017,10.1016/j.yexcr.2016.12.019,https://pubmed.ncbi.nlm.nih.gov/28017727/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,35205240,Investigation of the Genetic Architecture of Pigs Subjected to Breeding Intensification.,2022,10.3390/genes13020197,https://pubmed.ncbi.nlm.nih.gov/35205240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,31921621,Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications.,2019,10.3389/fonc.2019.01328,https://pubmed.ncbi.nlm.nih.gov/31921621/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,26330360,Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma.,2015,10.1038/srep13750,https://pubmed.ncbi.nlm.nih.gov/26330360/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,25761692,Heparan sulfate 6-O-sulfotransferase 3 is involved in bone marrow mesenchymal stromal cell osteogenic differentiation‍.,2015,10.1134/s000629791503013x,https://pubmed.ncbi.nlm.nih.gov/25761692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,32147644,Differential Effect of Polymorphisms on Body Mass Index Across the Life Course of Japanese: The Japan Multi-Institutional Collaborative Cohort Study.,2021,10.2188/jea.je20190296,https://pubmed.ncbi.nlm.nih.gov/32147644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,31320595,Impact of AAV2 and Hepatitis B Virus Integration Into Genome on Development of Hepatocellular Carcinoma in Patients with Prior Hepatitis B Virus Infection.,2019,10.1158/1078-0432.ccr-18-4041,https://pubmed.ncbi.nlm.nih.gov/31320595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,24412195,Changes in glycosaminoglycan structure on differentiation of human embryonic stem cells towards mesoderm and endoderm lineages.,2014,10.1016/j.bbagen.2014.01.007,https://pubmed.ncbi.nlm.nih.gov/24412195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,21951307,Analysis of axon guidance defects at the optic chiasm in heparan sulphate sulphotransferase compound mutant mice.,2011,10.1111/j.1469-7580.2011.01432.x,https://pubmed.ncbi.nlm.nih.gov/21951307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,23563607,Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.,2013,10.1038/ng.2606,https://pubmed.ncbi.nlm.nih.gov/23563607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,27863428,Impact of diabetes-related gene polymorphisms on the clinical characteristics of type 2 diabetes Chinese Han population.,2016,10.18632/oncotarget.13399,https://pubmed.ncbi.nlm.nih.gov/27863428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,22903264,Cartilage tumour progression is characterized by an increased expression of heparan sulphate 6O-sulphation-modifying enzymes.,2012,10.1007/s00428-012-1300-5,https://pubmed.ncbi.nlm.nih.gov/22903264/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,18837045,Tetra-amelia and lung hypo/aplasia syndrome: new case report and review.,2008,10.1002/ajmg.a.32489,https://pubmed.ncbi.nlm.nih.gov/18837045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HS6ST3,ENSG00000185352,Unsafe,21310492,Genome-wide association study of diabetic retinopathy in a Taiwanese population.,2011,10.1016/j.ophtha.2010.07.020,https://pubmed.ncbi.nlm.nih.gov/21310492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,42278287,Multi-Omics Integration and Causal Inference Identify HSD17B1 as a Potential Nobiletin Target Linking Neurosteroid Metabolism to Alzheimer's Disease.,2026,10.3390/ijms27114756,https://pubmed.ncbi.nlm.nih.gov/42278287/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,42210128,"Reduced HSD17B1 expression in preeclampsia: integrated transcriptomic, summary Mendelian randomization, immune deconvolution, and experimental validation.",2026,10.1186/s12884-026-09317-5,https://pubmed.ncbi.nlm.nih.gov/42210128/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,41219171,Female Mice with HSD17B1 Inactivation Show Mild Hyperandrogenism without Notable Impact on Reproductive Function or Bone.,2025,10.1210/endocr/bqaf167,https://pubmed.ncbi.nlm.nih.gov/41219171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,42068772,Genome-wide identification and transcriptomic reprogramming of the hsd17b gene family during endocrine-induced sex reversal in mandarin fish (Siniperca chuatsi).,2026,10.1016/j.cbd.2026.101851,https://pubmed.ncbi.nlm.nih.gov/42068772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,42705557,Postnatal expression of phoenixin-14 and GPR173 gene and protein in the mice testis and its effect on steroidogenesis in the early stage.,2027,10.1016/j.jsbmb.2026.107119,https://pubmed.ncbi.nlm.nih.gov/42705557/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,41629966,Sex-specific gonadal transcriptome during early development of Siberian sturgeon.,2026,10.1186/s13293-025-00810-8,https://pubmed.ncbi.nlm.nih.gov/41629966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,42196271,"The Expression of Placental 17β-Hydroxysteroid Dehydrogenase Genes Is Associated with the Elevation of Active Androgens and Estrogens in Pregnant Women, but Does Not Affect 11-Oxygenated C19 Steroids.",2026,10.3390/ijms27104290,https://pubmed.ncbi.nlm.nih.gov/42196271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,40394177,HSD17B1-mediated trophoblast differentiation lowers estrogen levels in early-onset preeclampsia.,2025,10.1038/s41598-025-02490-1,https://pubmed.ncbi.nlm.nih.gov/40394177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,41226409,The Anti-Cancer Potential of Genistein: Single-Cell RNA Sequencing Analysis and Spatial Transcriptome Reveal That Genistein Targets HSD17B1 to Inhibit the Progression of Gastric Adenocarcinoma.,2025,10.3390/ijms262110369,https://pubmed.ncbi.nlm.nih.gov/41226409/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,42008046,Gonadal Transcriptomic Atlas Reveals Conserved and Sex-Biased Regulatory Networks in Black-Spotted Croaker (Protonibea diacanthus).,2026,10.1007/s10126-026-10613-6,https://pubmed.ncbi.nlm.nih.gov/42008046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,42665132,Endocrine disrupting effects of estrone on male Siniperca chuatsi: From gonadal remodeling to gene regulation.,2027,10.1016/j.jsbmb.2026.107107,https://pubmed.ncbi.nlm.nih.gov/42665132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,39949363,Dietary DHA Regulated the Androgen Production in Male Chinese Tongue Sole Cynoglossus semilaevis.,2025,10.1155/anu/9318358,https://pubmed.ncbi.nlm.nih.gov/39949363/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,41469704,17β-Hydroxysteroid dehydrogenases 1 and 2: potential markers for breast cancer recurrence and tamoxifen resistance among premenopausal women diagnosed with breast cancer in Denmark.,2025,10.1186/s13058-025-02196-2,https://pubmed.ncbi.nlm.nih.gov/41469704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,41514836,"Comparative RNA-Seq Analysis of Differentially Expressed Genes in the Testis and Ovary of Mudskipper, &lt;i&gt;Boleophthalmus pectinirostris&lt;/i&gt;.",2026,10.3390/ani16010150,https://pubmed.ncbi.nlm.nih.gov/41514836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,41390424,Deciphering the gonadal cell atlas of Monopterus albus and cell fate during sex reversal based on single-cell RNA sequencing.,2025,10.1186/s13287-025-04810-8,https://pubmed.ncbi.nlm.nih.gov/41390424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,42232754,FCGBP links hormonal imbalance and hepatic steatosis in PCOS-NAFLD comorbidity: an integrative bioinformatics and experimental study.,2026,10.3389/fendo.2026.1750425,https://pubmed.ncbi.nlm.nih.gov/42232754/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,38994724,Steroid metabolism and hormonal dynamics in normal and malignant ovaries.,2024,10.1042/ebc20240028,https://pubmed.ncbi.nlm.nih.gov/38994724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,40257693,Impact of Missense Variants on the Structure and Function of Polycystic Ovary Syndrome-Associated HSD17B1 Gene.,2026,10.1007/s10528-025-11106-2,https://pubmed.ncbi.nlm.nih.gov/40257693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,42794115,"Dietary Fermented Strawberry Pomace Improves Yolk Lipid Quality and Modulates Reproductive Endocrine Activity, Intestinal Barrier Status, and Cecal Microbiota in Laying Hens.",2026,10.3390/foods15183331,https://pubmed.ncbi.nlm.nih.gov/42794115/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,41027258,MicroRNA mediated downregulation of HSD17B1 impairs estrone-to-estradiol conversion in polycystic ovarian syndrome.,2025,10.1016/j.repbio.2025.101085,https://pubmed.ncbi.nlm.nih.gov/41027258/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,41689082,"Correction to: An integrated approach of network pharmacology, molecular docking, and experimental verification uncovers kaempferol as the effective modulator of HSD17B1 for treatment of endometrial cancer.",2026,10.1186/s12967-026-07698-x,https://pubmed.ncbi.nlm.nih.gov/41689082/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,41601040,Exposure to paraben in early gestational period: Impact on placental estrogen biosynthesis and fetal growth restriction.,2026,10.1016/j.ecoenv.2025.119605,https://pubmed.ncbi.nlm.nih.gov/41601040/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,42349562,Curcuminoids-enriched standardized extract of Haridra (Curcuma longa) rhizome restored the level of dehydroepiandrosterone (DHEA) and hemodynamics in a rodent model of hypertension.,2026,10.1016/j.fitote.2026.107350,https://pubmed.ncbi.nlm.nih.gov/42349562/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,42863735,Halogenated disinfectants inhibit human and rat 17β-Hydroxysteroid dehydrogenase 1 activity and disrupt estradiol synthesis: Implications for endocrine disruption.,2026,10.1016/j.cbi.2026.112383,https://pubmed.ncbi.nlm.nih.gov/42863735/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,42903404,Bisphenol M Impairs Ovarian Function through Disrupting Estrogen Synthesis in Female Mice: A Comparative Study with Bisphenol A.,2026,10.1021/envhealth.6c00098,https://pubmed.ncbi.nlm.nih.gov/42903404/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,42833507,Dimethomorph exposure alters human granulosa cells and mouse ovarian physiology.,2026,10.1016/j.tox.2026.154609,https://pubmed.ncbi.nlm.nih.gov/42833507/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,42710202,Association of organophosphate flame retardant exposure with female infertility: Cross-sectional and mechanistic evidence.,2026,10.1016/j.ecoenv.2026.120780,https://pubmed.ncbi.nlm.nih.gov/42710202/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,42119666,"FSH mediated endocrine disruption potential of Dibutyl phthalate in cultured ovine ovarian granulosa cells: Cytotoxicity, oxidative stress, steroidogenesis, cell senescence, and expression of related key developmental genes.",2026,10.1016/j.reprotox.2026.109262,https://pubmed.ncbi.nlm.nih.gov/42119666/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,38850011,Identification of Hydroxysteroid Dehydrogenase Type 1 As a Potential Bladder Tumor Marker.,2024,10.61186/ibj.4068,https://pubmed.ncbi.nlm.nih.gov/38850011/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,39075554,Development of a propionate metabolism-related gene-based molecular subtypes and scoring system for predicting prognosis in bladder cancer.,2024,10.1186/s40001-024-01982-6,https://pubmed.ncbi.nlm.nih.gov/39075554/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,41966789,Ligand-based directed differentiation to produce granulosa-like cells expressing steroidogenic enzyme genes.,2026,10.1016/j.scr.2026.103978,https://pubmed.ncbi.nlm.nih.gov/41966789/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,40741887,Target-Specific Potency and Drug-Ability Profile of Flavonoids Against Lung Cancer: An Integrative Multi-Omics Approach for Lead Identification.,2025,10.1002/ddr.70131,https://pubmed.ncbi.nlm.nih.gov/40741887/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,36932403,"An integrated approach of network pharmacology, molecular docking, and experimental verification uncovers kaempferol as the effective modulator of HSD17B1 for treatment of endometrial cancer.",2023,10.1186/s12967-023-04048-z,https://pubmed.ncbi.nlm.nih.gov/36932403/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,41626053,Effect of &lt;i&gt;Cordyceps militaris&lt;/i&gt; Extract on Visceral Adipose Tissue Changes After Ovariectomy in Rodents.,2026,10.1155/ije/6699051,https://pubmed.ncbi.nlm.nih.gov/41626053/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,37758070,Single and mixture toxicity evaluation of avobenzone and homosalate to male zebrafish and H295R cells.,2023,10.1016/j.chemosphere.2023.140271,https://pubmed.ncbi.nlm.nih.gov/37758070/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B1,ENSG00000108786,Unsafe,37987225,"Selenium reduces acrylamide-induced testicular toxicity in rats by regulating HSD17B1, StAR, and CYP17A1 expression, oxidative stress, inflammation, apoptosis, autophagy, and DNA damage.",2024,10.1002/tox.23996,https://pubmed.ncbi.nlm.nih.gov/37987225/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,42745784,Study on the mechanism of SW inhibiting testosterone synthesis in mouse Leydig cells.,2026,10.3389/fvets.2026.1912572,https://pubmed.ncbi.nlm.nih.gov/42745784/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,42441894,Chlorogenic Acid Attenuates Busulfan-Induced Azoospermia in Rats: Antioxidant-Mediated Restoration of Spermatogenesis and Steroidogenesis - A Stereological and Molecular Analysis.,2026,10.5935/1518-0557.20260037,https://pubmed.ncbi.nlm.nih.gov/42441894/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,41392108,Methoxsalen deteriorative effects on the testicular parenchyma and testosterone synthesis gene expression in male rats.,2025,10.1038/s41598-025-32683-7,https://pubmed.ncbi.nlm.nih.gov/41392108/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,42665423,Ramelteon Mitigates Cisplatin-induced Testicular Dysfunction in Rats.,2026,10.21873/invivo.14434,https://pubmed.ncbi.nlm.nih.gov/42665423/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,42390145,Clinical management and genetic variation analysis of patients with 17β-hydroxysteroid dehydrogenase deficiency.,2026,10.1177/03000605261463063,https://pubmed.ncbi.nlm.nih.gov/42390145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,41158715,Therapeutic Potential of &lt;i&gt;Cynara scolymus&lt;/i&gt; Extract and &lt;i&gt;Bifidobacterium longum&lt;/i&gt; in Alleviating Diabetes-Induced Male Reproductive Dysfunction.,2025,10.1155/ije/5884930,https://pubmed.ncbi.nlm.nih.gov/41158715/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,42741146,Long-term testicular changes caused by the temporary suspension of puberty initiated at different stages of development.,2026,10.3389/fcell.2026.1936689,https://pubmed.ncbi.nlm.nih.gov/42741146/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,42807274,Novel circNSD2 promotes proliferation and testosterone synthesis while inhibiting apoptosis in bovine Leydig cells.,2026,10.3389/fvets.2026.1932131,https://pubmed.ncbi.nlm.nih.gov/42807274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,42298429,Multi-omics unravels testis-regulated genetic mechanism of musk secretion in muskrat (Ondatra zibethicus).,2026,10.1186/s12864-026-13019-9,https://pubmed.ncbi.nlm.nih.gov/42298429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,40336300,Functional Analysis of HSD17B3-Deficient Male Mice Reveals Roles for HSD17B7 and HSD17B12 in Testosterone Biosynthesis.,2025,10.1210/endocr/bqaf078,https://pubmed.ncbi.nlm.nih.gov/40336300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,42196271,"The Expression of Placental 17β-Hydroxysteroid Dehydrogenase Genes Is Associated with the Elevation of Active Androgens and Estrogens in Pregnant Women, but Does Not Affect 11-Oxygenated C19 Steroids.",2026,10.3390/ijms27104290,https://pubmed.ncbi.nlm.nih.gov/42196271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,41934337,Testosterone Exposure During Fetal Masculinization Programming Window Determines the Kidney Size in Adult Mice.,2026,10.1096/fj.202500761rr,https://pubmed.ncbi.nlm.nih.gov/41934337/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,41013757,Genetic variants (Lhcgr&lt;sup&gt;W495X/+&lt;/sup&gt;) and environmental toxicants (DEHP) synergistically induce DSD by interfering with steroidogenic gene expression.,2025,10.1186/s13293-025-00753-0,https://pubmed.ncbi.nlm.nih.gov/41013757/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,42834443,Prepubertal exposure to SARS-CoV-2 single-stranded RNA disrupts spermatogenesis and causes intergenerational effects in mice.,2026,10.1093/molehr/gaag059,https://pubmed.ncbi.nlm.nih.gov/42834443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,39139451,Dynamics of HSD17B3 expression in human fetal testis: implications for the role of Sertoli cells in fetal testosterone biosynthesis.,2024,10.3389/fcell.2024.1429292,https://pubmed.ncbi.nlm.nih.gov/39139451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,39556387,Compensatory mechanisms that maintain androgen production in mice lacking key androgen biosynthetic enzymes.,2024,10.1096/fj.202402093r,https://pubmed.ncbi.nlm.nih.gov/39556387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,41594515,Transcriptomics Analysis of Testis Development in Thamnaconus septentrionalis Responding to a Rise in Temperature.,2026,10.3390/ani16020327,https://pubmed.ncbi.nlm.nih.gov/41594515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,42603415,Hsd3b7 regulates ovarian development and maturation via steroidogenesis and lipid metabolism in Qihe gibel carp (Carassius gibelio var. Qihe).,2026,10.1016/j.anireprosci.2026.108310,https://pubmed.ncbi.nlm.nih.gov/42603415/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,41470754,Anthocyanin-Rich Blackcurrant Pomace Mitigates Oxidative Stress and Affects Steroid Metabolism in the Testes of Rats Exposed to Silver Nanoparticles.,2025,10.3390/nu17243809,https://pubmed.ncbi.nlm.nih.gov/41470754/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,42320039,Fibroblast Growth Factor 9 promotes rat Leydig cell development via H3K4me3 histone modifications.,2026,10.1093/reprod/xaag076,https://pubmed.ncbi.nlm.nih.gov/42320039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,41605281,Early-life BPS exposure induces reproductive toxicity in offspring mice via ferroptosis.,2026,10.1016/j.reprotox.2026.109175,https://pubmed.ncbi.nlm.nih.gov/41605281/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,42064059,Shared molecular features and potential diagnostic biomarkers between ulcerative colitis and sarcopenia: an integrative bioinformatics analysis with preliminary experimental validation.,2026,10.3389/fimmu.2026.1801914,https://pubmed.ncbi.nlm.nih.gov/42064059/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,40398521,Bisphenol Z inhibits the function of Leydig cells via upregulation of METTL3 expression in adult male rats.,2025,10.1016/j.jsbmb.2025.106786,https://pubmed.ncbi.nlm.nih.gov/40398521/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,41730512,"Morphological, histopathological, and transcriptomic analyses of gonads reveal reproductive impacts of levonorgestrel (LNG) exposure on Gambusia affinis.",2026,10.1016/j.jsbmb.2026.106966,https://pubmed.ncbi.nlm.nih.gov/41730512/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,40954150,"Co-administration of Spirulina and L-carnitine preserves ovarian reserve in a rat model of premature ovarian insufficiency via SIRT1 regulation of oxidative stress, inflammation, and apoptosis.",2025,10.1038/s41598-025-11143-2,https://pubmed.ncbi.nlm.nih.gov/40954150/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,40602269,Reproductive toxicity of glyphosate and its main metabolite aminomethyl phosphonic acid (AMPA) on zebrafish (Danio rerio).,2025,10.1016/j.chemosphere.2025.144548,https://pubmed.ncbi.nlm.nih.gov/40602269/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,41038008,Reproductive toxicity of chronic exposure to cortisone in western mosquitofish (Gambusia affinis).,2025,10.1016/j.aquatox.2025.107587,https://pubmed.ncbi.nlm.nih.gov/41038008/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,40155689,Synergistic endocrine disruption and cellular toxicity of polyethylene microplastics and bisphenol A in MLTC-1 cells and zebrafish.,2025,10.1038/s41598-025-94902-5,https://pubmed.ncbi.nlm.nih.gov/40155689/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,40816056,Dietary supplementation of selenium nanoparticle improves the vitellogenesis and fecundity of female zebrafish.,2025,10.1016/j.cbd.2025.101604,https://pubmed.ncbi.nlm.nih.gov/40816056/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,41031455,Role of the Maillard reaction products of oyster peptides and chitosan oligosaccharide in chelation with zinc: restoring testicular injury and the testosterone synthesis pathway.,2025,10.1039/d5fo01313e,https://pubmed.ncbi.nlm.nih.gov/41031455/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,38590960,Prenatal DEHP exposure induces lifelong testicular toxicity by continuously interfering with steroidogenic gene expression.,2024,10.21037/tau-23-503,https://pubmed.ncbi.nlm.nih.gov/38590960/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,39919587,Bisphenol B restrains rat leydig cell function via H3K27me3/H3K9me3 histone modifications.,2025,10.1016/j.ecoenv.2025.117847,https://pubmed.ncbi.nlm.nih.gov/39919587/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD17B3,ENSG00000130948,Unsafe,8075637,Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3.,1994,10.1038/ng0594-34,https://pubmed.ncbi.nlm.nih.gov/8075637/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,42237942,Knockout of &lt;i&gt;hsd3b1&lt;/i&gt; disrupts steroid hormone homeostasis and compromises gonadal development in zebrafish.,2026,10.24272/j.issn.2095-8137.2025.329,https://pubmed.ncbi.nlm.nih.gov/42237942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,42450712,Transcriptomic Profiling of Canine Testicular Leydig Cell Tumors Uncovers Key Upregulated Gene Pathways.,2026,10.3390/ani16132005,https://pubmed.ncbi.nlm.nih.gov/42450712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,42294886,HSD3B1 links ileal steroid metabolism to bile acid regulation in patients with prostate cancer.,2026,10.1172/jci202725,https://pubmed.ncbi.nlm.nih.gov/42294886/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,42765541,"Integrative Genetic and Bioinformatic Analysis of Androgen Pathway Gene Polymorphisms, Testosterone, and PSA Levels in Prostate Cancer.",2026,10.1177/19450265261488655,https://pubmed.ncbi.nlm.nih.gov/42765541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,42518214,3beta-HSD1-mediated steroid back-conversion maintains androgen signaling in prostate cancer.,2026,10.1158/1541-7786.mcr-26-0243,https://pubmed.ncbi.nlm.nih.gov/42518214/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,42882994,Chronic Energy Restriction Is Associated with Impaired Follicular Development and Hepatic Bile Acid Remodeling in Mice.,2026,10.3390/ani16193025,https://pubmed.ncbi.nlm.nih.gov/42882994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,42008046,Gonadal Transcriptomic Atlas Reveals Conserved and Sex-Biased Regulatory Networks in Black-Spotted Croaker (Protonibea diacanthus).,2026,10.1007/s10126-026-10613-6,https://pubmed.ncbi.nlm.nih.gov/42008046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,42342004,Chlorocholine chloride disrupts differentiation of rat stem/progenitor Leydig cells: A combined in vivo and in vitro study by Leydig cell regeneration model.,2026,10.1016/j.etap.2026.105085,https://pubmed.ncbi.nlm.nih.gov/42342004/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,41514836,"Comparative RNA-Seq Analysis of Differentially Expressed Genes in the Testis and Ovary of Mudskipper, &lt;i&gt;Boleophthalmus pectinirostris&lt;/i&gt;.",2026,10.3390/ani16010150,https://pubmed.ncbi.nlm.nih.gov/41514836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,42869354,Maternal cannabis use during pregnancy associates with alterations in placental endocannabinoid- and steroid-homeostasis and morphology.,2026,10.1016/j.taap.2026.118080,https://pubmed.ncbi.nlm.nih.gov/42869354/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,41437114,MSI2 in the dentate gyrus and ovary regulates the reproductive endocrine homeostasis of female mice.,2025,10.1038/s42003-025-09086-5,https://pubmed.ncbi.nlm.nih.gov/41437114/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,41204352,Sexually dimorphic responses in androgen metabolism and signalling in the non-human primate placenta to moderate maternal undernutrition.,2025,10.1186/s13293-025-00771-y,https://pubmed.ncbi.nlm.nih.gov/41204352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,41023281,Association between CYP17A1 and HSD3B1 gene polymorphisms and testosterone levels in Nigerian prostate cancer patients.,2025,10.1038/s41598-025-18752-x,https://pubmed.ncbi.nlm.nih.gov/41023281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,42571812,Disruption of progesterone synthesis by PBDEs: Potent inhibition of human and rat placental 3β-hydroxysteroid dehydrogenase by the metabolite 4-Bromodiphenyl ether.,2026,10.1016/j.taap.2026.117989,https://pubmed.ncbi.nlm.nih.gov/42571812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,40329180,Combining ATAC-seq and RNA-seq reveals key genes for gonadal abnormalities in one-month-old XX-DSD pigs.,2025,10.1186/s12864-025-11613-x,https://pubmed.ncbi.nlm.nih.gov/40329180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,42511920,"Functional In Vitro Model of the Canine Corpus Luteum: Isolation, Culture and Characterization of Steroidogenically Active Luteal Cells.",2026,10.3390/biomedicines14071444,https://pubmed.ncbi.nlm.nih.gov/42511920/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,41664980,Loss of GPR133 Promotes Enzalutamide Resistance in Prostate Cancer by Upregulating HSD3B1 and Intratumoral Androgen Synthesis.,2026,10.1002/pros.70138,https://pubmed.ncbi.nlm.nih.gov/41664980/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,41352196,"Effect of selenium-enriched Ganoderma lucidum powder in testicular tissues, oxidative stress biomarkers and antiapoptotic capacities in roosters.",2026,10.1016/j.psj.2025.106185,https://pubmed.ncbi.nlm.nih.gov/41352196/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,41787812,SF-1 Downregulation and Steroidogenic Disruption in Male Rats Exposed to Silica Nanoparticles (SiO&lt;sub&gt;2&lt;/sub&gt;) for 90 Days.,2026,10.1002/jat.70135,https://pubmed.ncbi.nlm.nih.gov/41787812/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,42118438,Effects of intracerebroventricular Metrnl administration on the hypothalamic-pituitary-testicular axis in male rats.,2026,10.1007/s11033-026-11938-0,https://pubmed.ncbi.nlm.nih.gov/42118438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,40744833,Prostate cancer germline variants with therapeutic implications.,2026,10.1016/j.molmed.2025.07.004,https://pubmed.ncbi.nlm.nih.gov/40744833/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,40544998,HSD3B1 upregulation via LRH1 sustains estrogen receptor signaling and promotes endocrine resistance in breast cancer.,2025,10.1016/j.jbc.2025.110405,https://pubmed.ncbi.nlm.nih.gov/40544998/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,42913038,Mindfulness-based stress reduction during pregnancy is associated with changes in placental fatty acid metabolism and endocrine function.,2026,10.1016/j.placenta.2026.10.004,https://pubmed.ncbi.nlm.nih.gov/42913038/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,39168093,HSD3B1 genotype and outcomes in metastatic hormone-sensitive prostate cancer with androgen deprivation therapy and enzalutamide: ARCHES.,2024,10.1016/j.xcrm.2024.101644,https://pubmed.ncbi.nlm.nih.gov/39168093/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,42070867,Environmentally relevant concentrations of nanoplastic increase the accumulation and endocrine effects of BDE47 and its metabolite 6-OH-BDE-47 in male frogs' testes.,2026,10.1016/j.jes.2025.10.023,https://pubmed.ncbi.nlm.nih.gov/42070867/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,42570474,"Effects and mechanisms of NMB knockdown on cell proliferation, apoptosis and steroidogenesis in porcine ovarian granulosa cells.",2026,10.1016/j.theriogenology.2026.118125,https://pubmed.ncbi.nlm.nih.gov/42570474/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,41252049,Utilizing a novel mitochondrial-related gene signature for predicting the prognosis and immunological impact in bladder cancer.,2025,10.1007/s12672-025-03927-9,https://pubmed.ncbi.nlm.nih.gov/41252049/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,41601040,Exposure to paraben in early gestational period: Impact on placental estrogen biosynthesis and fetal growth restriction.,2026,10.1016/j.ecoenv.2025.119605,https://pubmed.ncbi.nlm.nih.gov/41601040/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,42710202,Association of organophosphate flame retardant exposure with female infertility: Cross-sectional and mechanistic evidence.,2026,10.1016/j.ecoenv.2026.120780,https://pubmed.ncbi.nlm.nih.gov/42710202/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,41534335,Crosstalk with the cholinergic pathway may be responsible for chlorpyrifos-induced reproductive toxicity in fish.,2026,10.1016/j.aquatox.2026.107710,https://pubmed.ncbi.nlm.nih.gov/41534335/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,40282446,"The Influence of the Germline &lt;i&gt;HSD3B1&lt;/i&gt; Adrenal-Permissive Allele (c.1100 C) on the Somatic Alteration Landscape, the Transcriptome, and Immune Cell Infiltration in Prostate Cancer.",2025,10.3390/cancers17081270,https://pubmed.ncbi.nlm.nih.gov/40282446/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,39718999,"A Novel Organophosphate Ester, Tris(2,4-di&lt;i&gt;tert&lt;/i&gt;-butylphenyl) Phosphate, Induced Reproductive Toxicity in Male Zebrafish at Environmentally Relevant Concentrations.",2025,10.1021/acs.est.4c10931,https://pubmed.ncbi.nlm.nih.gov/39718999/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,39286977,Survival of men with metastatic hormone-sensitive prostate cancer and adrenal-permissive HSD3B1 inheritance.,2024,10.1172/jci183583,https://pubmed.ncbi.nlm.nih.gov/39286977/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,41990565,Swainsonine induces granulosa cell apoptosis and steroidogenic impairment associated with oxidative stress and mitochondrial dysfunction.,2026,10.1016/j.anireprosci.2026.108177,https://pubmed.ncbi.nlm.nih.gov/41990565/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,40565184,&lt;i&gt;HSD3B1&lt;/i&gt; (c.1100C) Genotype Is Associated with Distinct Tumoral and Clinical Outcomes in Breast and Endometrial Cancers.,2025,10.3390/ijms26125720,https://pubmed.ncbi.nlm.nih.gov/40565184/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,42119666,"FSH mediated endocrine disruption potential of Dibutyl phthalate in cultured ovine ovarian granulosa cells: Cytotoxicity, oxidative stress, steroidogenesis, cell senescence, and expression of related key developmental genes.",2026,10.1016/j.reprotox.2026.109262,https://pubmed.ncbi.nlm.nih.gov/42119666/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSD3B1,ENSG00000203857,Unsafe,1401999,"Characterization, expression, and immunohistochemical localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in human skin.",1992,10.1111/1523-1747.ep12616131,https://pubmed.ncbi.nlm.nih.gov/1401999/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,42669620,ANGII Initiated HSF2 Trans-Activating HIF-1α Through Induction of ER Stress to Promote Cardiac Hypertrophy.,2026,10.1111/1440-1681.70153,https://pubmed.ncbi.nlm.nih.gov/42669620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,41914024,Heat shock transcription factors in development and disease.,2026,10.1242/dmm.052700,https://pubmed.ncbi.nlm.nih.gov/41914024/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,41913266,Testis-specific lncRNA Teshl regulates acrosome biogenesis to maintain sperm structure and function.,2026,10.1186/s13578-026-01563-6,https://pubmed.ncbi.nlm.nih.gov/41913266/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,40318841,HDAC1 is involved in the destabilization of the HSF2 protein under nonstress and stress conditions.,2025,10.1016/j.cstres.2025.100079,https://pubmed.ncbi.nlm.nih.gov/40318841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,40901953,HSF2 drives breast cancer progression by acting as a stage-specific switch between proliferation and invasion.,2025,10.1126/sciadv.ady1289,https://pubmed.ncbi.nlm.nih.gov/40901953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,41995727,HSF2-HSP110 axis supports genome stability via RNA polymerase II transcription and DNA repair.,2026,10.1083/jcb.202508059,https://pubmed.ncbi.nlm.nih.gov/41995727/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,38641046,"Hsf1 and Hsf2 in normal, healthy human tissues: Immunohistochemistry provokes new questions.",2024,10.1016/j.cstres.2024.04.004,https://pubmed.ncbi.nlm.nih.gov/38641046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,42176908,CHD4 is a copper sensor linking chromatin remodeling to cuproptosis.,2026,10.1016/j.freeradbiomed.2026.05.314,https://pubmed.ncbi.nlm.nih.gov/42176908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,42854502,Integrative transcriptomic analysis reveals tissue associated molecular responses to heat stress in chickens.,2026,10.1016/j.psj.2026.107884,https://pubmed.ncbi.nlm.nih.gov/42854502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,38458311,Comprehensive analysis of human tissues reveals unique expression and localization patterns of HSF1 and HSF2.,2024,10.1016/j.cstres.2024.03.001,https://pubmed.ncbi.nlm.nih.gov/38458311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,40427320,The Function of Heat Shock Transcription Factors in Sex Differentiation in &lt;i&gt;Cynoglossus semilaevis&lt;/i&gt;.,2025,10.3390/ani15101443,https://pubmed.ncbi.nlm.nih.gov/40427320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,40440295,Heat shock transcription factor 2 reduces mitochondrial pathway apoptosis in intestinal epithelial cells by inhibiting the increase in mitochondrial membrane permeability in ulcerative colitis.,2025,10.1371/journal.pone.0325275,https://pubmed.ncbi.nlm.nih.gov/40440295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,41966299,Functional interplay between heat shock protein 90 (HSP90) and heat shock factors (HSFs).,2026,10.1016/j.cstres.2026.100177,https://pubmed.ncbi.nlm.nih.gov/41966299/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,42821571,"Transcription factor activity divergence across muscle atrophy conditions: A comparative analysis of spaceflight, aging, and disuse using decoupleR.",2026,10.1371/journal.pone.0359659,https://pubmed.ncbi.nlm.nih.gov/42821571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,40245053,Heat shock factor 2 regulates oncogenic gamma-herpesvirus gene expression by remodeling the chromatin at the ORF50 and BZLF1 promoter.,2025,10.1371/journal.ppat.1013108,https://pubmed.ncbi.nlm.nih.gov/40245053/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,38791628,The Expression and Epigenetic Characteristics of the HSF2 Gene in Cattle-Yak and the Correlation with Its Male Sterility.,2024,10.3390/ani14101410,https://pubmed.ncbi.nlm.nih.gov/38791628/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,36430241,"Heat Shock Transcription Factor 2 Is Significantly Involved in Neurodegenerative Diseases, Inflammatory Bowel Disease, Cancer, Male Infertility, and Fetal Alcohol Spectrum Disorder: The Novel Mechanisms of Several Severe Diseases.",2022,10.3390/ijms232213763,https://pubmed.ncbi.nlm.nih.gov/36430241/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,39285620,Proteomic profiling identifies a direct interaction between heat shock transcription factor 2 and the focal adhesion adapter talin-1.,2024,10.1111/febs.17271,https://pubmed.ncbi.nlm.nih.gov/39285620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,39950604,Loss of lncRNAs 1700101O22Rik and 1700027A15Rik causes sperm malformation and subfertility.,2025,10.1111/andr.70011,https://pubmed.ncbi.nlm.nih.gov/39950604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,41982165,Ubiquitin-dependent degradation of MBD3 by TRIM59 promotes lung adenocarcinoma.,2026,10.3724/abbs.2026044,https://pubmed.ncbi.nlm.nih.gov/41982165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,38459027,Structural basis for self-discrimination by neoantigen-specific TCRs.,2024,10.1038/s41467-024-46367-9,https://pubmed.ncbi.nlm.nih.gov/38459027/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,34917120,Integrated Bioinformatics Analysis Identifies Heat Shock Factor 2 as a Prognostic Biomarker Associated With Immune Cell Infiltration in Hepatocellular Carcinoma.,2021,10.3389/fgene.2021.668516,https://pubmed.ncbi.nlm.nih.gov/34917120/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,35087869,"Pan-Cancer Integrated Analysis of HSF2 Expression, Prognostic Value and Potential Implications for Cancer Immunity.",2021,10.3389/fmolb.2021.789703,https://pubmed.ncbi.nlm.nih.gov/35087869/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,41009536,Genes Encoding Heat Shock Proteins Are Associated with Risk and Clinical Course of Severe COVID-19: A Pilot Study.,2025,10.3390/ijms26188967,https://pubmed.ncbi.nlm.nih.gov/41009536/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,37077914,Establishment and validation of exhausted CD8+ T cell feature as a prognostic model of HCC.,2023,10.3389/fimmu.2023.1166052,https://pubmed.ncbi.nlm.nih.gov/37077914/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,37999421,Toxicogenomic Effects of Dissolved Saxitoxin on the Early Life Stages of the Longfin Yellowtail (Seriola rivoliana).,2023,10.3390/md21110597,https://pubmed.ncbi.nlm.nih.gov/37999421/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,38998041,Use of Microalgae-Derived Astaxanthin to Improve Cytoprotective Capacity in the Ileum of Heat-Induced Oxidative Stressed Broilers.,2024,10.3390/ani14131932,https://pubmed.ncbi.nlm.nih.gov/38998041/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,38200094,Strong selection signatures for Aleutian disease tolerance acting on novel candidate genes linked to immune and cellular responses in American mink (Neogale vison).,2024,10.1038/s41598-023-51039-7,https://pubmed.ncbi.nlm.nih.gov/38200094/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,39615322,"Genome-wide analyses of genomic diversity, population structure and selection signatures in Italian turkey populations.",2025,10.1016/j.psj.2024.104543,https://pubmed.ncbi.nlm.nih.gov/39615322/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,34331200,Gambogic acid and gambogenic acid induce a thiol-dependent heat shock response and disrupt the interaction between HSP90 and HSF1 or HSF2.,2021,10.1007/s12192-021-01222-4,https://pubmed.ncbi.nlm.nih.gov/34331200/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,32607595,The proteostasis guardian HSF1 directs the transcription of its paralog and interactor HSF2 during proteasome dysfunction.,2021,10.1007/s00018-020-03568-x,https://pubmed.ncbi.nlm.nih.gov/32607595/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,34118349,The protective effect of nnano-selenium against cadmium-induced cerebellar injury via the heat shock protein pathway in chicken.,2021,10.1016/j.fct.2021.112332,https://pubmed.ncbi.nlm.nih.gov/34118349/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,34725587,The Role of Heat Shock Proteins in Cellular Homeostasis and Cell Survival.,2021,10.7759/cureus.18316,https://pubmed.ncbi.nlm.nih.gov/34725587/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,29180262,Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy.,2018,10.1016/j.ijcard.2017.10.102,https://pubmed.ncbi.nlm.nih.gov/29180262/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2,ENSG00000025156,Unsafe,29270451,Data supporting the angiotensin II activates MEL18 to deSUMOylate HSF2 for hypertension-related heart failure.,2018,10.1016/j.dib.2017.11.040,https://pubmed.ncbi.nlm.nih.gov/29270451/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,42259788,SUMOylation-driven nuclear translocation of HSF2BP alleviates MASLD via COX6A1-dependent mitochondrial reprogramming.,2026,10.1038/s41419-026-08935-3,https://pubmed.ncbi.nlm.nih.gov/42259788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,42854377,Meiotic recombination proteins in cancer.,2026,10.1016/j.dnarep.2026.103963,https://pubmed.ncbi.nlm.nih.gov/42854377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,41083582,HSF2BP modulates lung adenocarcinoma proliferation and immune microenvironment via BNC1/TGF-β/SMAD3 signaling pathway.,2025,10.1038/s41598-025-19564-9,https://pubmed.ncbi.nlm.nih.gov/41083582/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,39095423,MEILB2-BRME1 forms a V-shaped DNA clamp upon BRCA2-binding in meiotic recombination.,2024,10.1038/s41467-024-50920-x,https://pubmed.ncbi.nlm.nih.gov/39095423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,36964632,Overexpression of HSF2 binding protein suppresses endoplasmic reticulum stress via regulating subcellular localization of CDC73 in hepatocytes.,2023,10.1186/s13578-023-01010-w,https://pubmed.ncbi.nlm.nih.gov/36964632/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,36167792,HSF2BP protects against acute liver injury by regulating HSF2/HSP70/MAPK signaling in mice.,2022,10.1038/s41419-022-05282-x,https://pubmed.ncbi.nlm.nih.gov/36167792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,37889963,BRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombination.,2023,10.1126/sciadv.adi7352,https://pubmed.ncbi.nlm.nih.gov/37889963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,30760716,A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination.,2019,10.1038/s41467-019-08676-2,https://pubmed.ncbi.nlm.nih.gov/30760716/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,34326328,BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination.,2021,10.1038/s41467-021-24871-6,https://pubmed.ncbi.nlm.nih.gov/34326328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,34373645,Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites.,2021,10.1038/s41594-021-00635-0,https://pubmed.ncbi.nlm.nih.gov/34373645/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,35435115,Heat shock factor 2-binding protein promotes tumor progression via activation of MAPK signaling pathway in lung adenocarcinoma.,2022,10.1080/21655979.2022.2063561,https://pubmed.ncbi.nlm.nih.gov/35435115/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,37781246,Molecular landscapes of glioblastoma cell lines revealed a group of patients that do not benefit from WWOX tumor suppressor expression.,2023,10.3389/fnins.2023.1260409,https://pubmed.ncbi.nlm.nih.gov/37781246/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,32460033,Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic Recombination.,2020,10.1016/j.celrep.2020.107686,https://pubmed.ncbi.nlm.nih.gov/32460033/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,34790765,Prognostic significance of HSF2BP in lung adenocarcinoma.,2021,10.21037/atm-21-4935,https://pubmed.ncbi.nlm.nih.gov/34790765/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,32345962,The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.,2020,10.1038/s41467-020-15954-x,https://pubmed.ncbi.nlm.nih.gov/32345962/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,32845237,A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1.,2020,10.7554/elife.56996,https://pubmed.ncbi.nlm.nih.gov/32845237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,35174157,Pathogenic Variations of Homologous Recombination Gene HSF2BP Identified in Sporadic Patients With Premature Ovarian Insufficiency.,2021,10.3389/fcell.2021.768123,https://pubmed.ncbi.nlm.nih.gov/35174157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,32463460,MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis.,2020,10.1093/nar/gkaa406,https://pubmed.ncbi.nlm.nih.gov/32463460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,35624308,A truncating variant of RAD51B associated with primary ovarian insufficiency provides insights into its meiotic and somatic functions.,2022,10.1038/s41418-022-01021-z,https://pubmed.ncbi.nlm.nih.gov/35624308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,31960047,HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair.,2020,10.1093/nar/gkz1219,https://pubmed.ncbi.nlm.nih.gov/31960047/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,36356085,Immune and Genomic Analysis of Boxer Dog Breed and Its Relationship with Leishmania infantum Infection.,2022,10.3390/vetsci9110608,https://pubmed.ncbi.nlm.nih.gov/36356085/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,31270560,Exploring the dark genome: implications for precision medicine.,2019,10.1007/s00335-019-09809-0,https://pubmed.ncbi.nlm.nih.gov/31270560/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,31242413,HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.,2019,10.1016/j.celrep.2019.05.096,https://pubmed.ncbi.nlm.nih.gov/31242413/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSF2BP,ENSG00000160207,Unsafe,9651507,Novel testis-specific protein that interacts with heat shock factor 2.,1998,10.1016/s0378-1119(98)00208-x,https://pubmed.ncbi.nlm.nih.gov/9651507/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,42510767,"Genetic Analysis of the &lt;i&gt;HSPA1A&lt;/i&gt;, &lt;i&gt;HSPA1B&lt;/i&gt;, and &lt;i&gt;HSPA1L&lt;/i&gt; Genes in Patients with Schizophrenia from Taiwan.",2026,10.3390/genes17070727,https://pubmed.ncbi.nlm.nih.gov/42510767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,42677951,Changes in Activity of Heat Shock Protein-70 Family Genes Is Associated With Early Acute Pancreatitis Severity.,2026,10.1097/mpa.0000000000002686,https://pubmed.ncbi.nlm.nih.gov/42677951/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,42072126,Hesperidin from Chenpi Ameliorates Skin Photoaging by Targeting HSPA1L to Stabilize GPX4 and Suppress Ferroptosis.,2026,10.3390/antiox15040484,https://pubmed.ncbi.nlm.nih.gov/42072126/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,40788012,Heat shock protein A1L restricts influenza A virus by ubiquitination of NA.,2025,10.1128/jvi.00771-25,https://pubmed.ncbi.nlm.nih.gov/40788012/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,42402786,Complement System-Related Genes in Diabetic Nephropathy: Screening for Potential Targets of the Mechanism.,2026,10.1155/jdr/7117751,https://pubmed.ncbi.nlm.nih.gov/42402786/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,42216028,Physical exercise in combination with audiovisual stimulation alleviates cognitive and affective impairments in Alzheimer's disease model mice via restoring lysosomal membrane integrity.,2026,10.1186/s13195-026-02075-8,https://pubmed.ncbi.nlm.nih.gov/42216028/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,39972276,Identification of key genes related to unilateral cryptorchidism in sheep by comprehensive transcriptomics and proteomics analyses.,2025,10.1186/s12864-024-11166-5,https://pubmed.ncbi.nlm.nih.gov/39972276/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,39875989,VEGFR3 mitigates hypertensive nephropathy by enhancing mitophagy via regulating crotonylation of HSPA1L.,2025,10.1186/s12964-025-02045-x,https://pubmed.ncbi.nlm.nih.gov/39875989/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,40376285,Recent insights into depression from transcriptomic analysis.,2025,10.5114/ppn.2025.149873,https://pubmed.ncbi.nlm.nih.gov/40376285/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,42039770,"Evaluating the Effect of RNA Interference of Two Heat Shock Proteins (&lt;i&gt;HSPA1L&lt;/i&gt;, &lt;i&gt;HSP90B1&lt;/i&gt;) in Inducing Apoptosis in &lt;i&gt;Acyrthosiphon Pisum&lt;/i&gt;.",2026,,https://pubmed.ncbi.nlm.nih.gov/42039770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,42862824,Integrated bioinformatics analysis identifies an immune-related gene signature associated with non-obstructive azoospermia.,2026,10.1371/journal.pone.0360305,https://pubmed.ncbi.nlm.nih.gov/42862824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,41064490,Comprehensive Analysis and Experimental Validation of Immune-Related Biomarkers and Immune Microenvironment in Diabetic Nephropathy.,2025,10.2147/jir.s541886,https://pubmed.ncbi.nlm.nih.gov/41064490/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,42754162,Dynamic reprogramming and A-to-I RNA editing in neutrophils in response to tumor induction.,2026,10.1016/j.jbc.2026.113569,https://pubmed.ncbi.nlm.nih.gov/42754162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,41751191,Deciphering the Role of Postbiotics Derived from &lt;i&gt;Bacillus subtilis natto&lt;/i&gt; on LPS-Induced Endothelial Cell Dysfunction.,2026,10.3390/biomedicines14020293,https://pubmed.ncbi.nlm.nih.gov/41751191/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,40474128,Exploring heat shock protein-related biomarkers and subgroups in osteoarthritis using Gene Expression Omnibus data sets.,2025,10.1186/s12891-025-08827-1,https://pubmed.ncbi.nlm.nih.gov/40474128/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,39454876,Deciphering the role of heat shock protein HSPA1L: biomarker discovery and prognostic insights in Parkinson's disease and glioma.,2024,10.1016/j.slast.2024.100212,https://pubmed.ncbi.nlm.nih.gov/39454876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,42025242,Genome-wide identification and evolutionary analysis of the Hsp70 gene family in mandarin fish (Siniperca chuatsi): Insights into their differential expression under thermal and bacterial stress.,2026,10.1016/j.cbd.2026.101842,https://pubmed.ncbi.nlm.nih.gov/42025242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,32231871,The heat shock protein family gene Hspa1l in male mice is dispensable for fertility.,2020,10.7717/peerj.8702,https://pubmed.ncbi.nlm.nih.gov/32231871/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,41639228,"Bidirectional association between immune-mediated diseases and major depressive disorder: evidence from cohort, genome-wide pleiotropic, and experimental studies.",2026,10.1038/s41380-026-03459-w,https://pubmed.ncbi.nlm.nih.gov/41639228/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,41235944,Bioresponsive Nar-Zn@GelMA Hydrogel Reprograms the Diabetic Wound Microenvironment via Antioxidant and Immunoregulatory Synergy.,2026,10.1002/adhm.202503417,https://pubmed.ncbi.nlm.nih.gov/41235944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,42870608,"Lactylation-Related Gene Expression as a Predictor for Lung Adenocarcinoma Prognosis, Microenvironment Characteristics, and Therapeutic Reactions.",2026,10.1615/jenvironpatholtoxicoloncol.2025054335,https://pubmed.ncbi.nlm.nih.gov/42870608/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,39747468,"Comprehensive analysis of heat shock protein 110, 90, 70, 60 families and tumor immune microenvironment characterization in clear cell renal cell carcinoma.",2025,10.1038/s41598-024-84834-x,https://pubmed.ncbi.nlm.nih.gov/39747468/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,41465102,Surviving the Heat: Genetic Diversity and Adaptation in Sudanese Butana Cattle.,2025,10.3390/genes16121429,https://pubmed.ncbi.nlm.nih.gov/41465102/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,39200825,Preliminary Data on SNP of Transplantation-Related Genes after Haploidentical Stem Cell Transplantation.,2024,10.3390/jcm13164681,https://pubmed.ncbi.nlm.nih.gov/39200825/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,38835753,Genetic associations in ankylosing spondylitis: circulating proteins as drug targets and biomarkers.,2024,10.3389/fimmu.2024.1394438,https://pubmed.ncbi.nlm.nih.gov/38835753/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,36631012,[Identify the characteristic genes of dilated cardiomyopathy and immune cell infiltration based on bioinformatics and machine learning].,2023,,https://pubmed.ncbi.nlm.nih.gov/36631012/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,40206231,Polymorphisms of &lt;i&gt;HSP70&lt;/i&gt; genes are involved in the pathogenesis of idiopathic inflammatory myopathy.,2025,10.5114/reum/196740,https://pubmed.ncbi.nlm.nih.gov/40206231/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,37908310,Genetic overlap for ten cardiovascular diseases: A comprehensive gene-centric pleiotropic association analysis and Mendelian randomization study.,2023,10.1016/j.isci.2023.108150,https://pubmed.ncbi.nlm.nih.gov/37908310/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,32971893,HSPA1L Enhances Cancer Stem Cell-Like Properties by Activating IGF1Rβ and Regulating β-Catenin Transcription.,2020,10.3390/ijms21186957,https://pubmed.ncbi.nlm.nih.gov/32971893/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA1L,ENSG00000204390,Unsafe,9685725,Genomic structure of the spermatid-specific hsp70 homolog gene located in the class III region of the major histocompatibility complex of mouse and man.,1998,10.1093/oxfordjournals.jbchem.a022118,https://pubmed.ncbi.nlm.nih.gov/9685725/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,39991973,Mammalian heat shock protein A4 family ortholog Hsc70Cb is required for two phases of spermatogenesis in D. melanogaster.,2025,10.1530/rep-24-0458,https://pubmed.ncbi.nlm.nih.gov/39991973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,40919662,Methyltransferase-Like 3-Mediated m6A Modification of Heat Shock Protein Family A Member 4-Like Facilitates Interleukin-1β-Induced Chondrocyte Injury to Promote Osteoarthritis Progression.,2025,10.1002/jbt.70492,https://pubmed.ncbi.nlm.nih.gov/40919662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,39972276,Identification of key genes related to unilateral cryptorchidism in sheep by comprehensive transcriptomics and proteomics analyses.,2025,10.1186/s12864-024-11166-5,https://pubmed.ncbi.nlm.nih.gov/39972276/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,38654926,Proteomic biomarkers in seminal plasma as predictors of reproductive potential in azoospermic men.,2024,10.3389/fendo.2024.1327800,https://pubmed.ncbi.nlm.nih.gov/38654926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,41422114,Molecular signatures and machine learning driven stress biomarkers for rainbow trout aquaculture and climate adaptation.,2025,10.1038/s41598-025-30120-3,https://pubmed.ncbi.nlm.nih.gov/41422114/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,41613202,Transcriptomic changes induced by controlled cyclical heat stress in the bovine mammary gland during lactation.,2025,10.3168/jdsc.2025-0760,https://pubmed.ncbi.nlm.nih.gov/41613202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,38912589,Protein disulfide isomerase is essential for spermatogenesis in mice.,2024,10.1172/jci.insight.177743,https://pubmed.ncbi.nlm.nih.gov/38912589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,37574561,Human umbilical cord mesenchymal stem cells (hUC-MSCs) alleviate paclitaxel-induced spermatogenesis defects and maintain male fertility.,2023,10.1186/s40659-023-00459-w,https://pubmed.ncbi.nlm.nih.gov/37574561/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,39106693,The combination of RNA-seq transcriptomics and data-independent acquisition proteomics reveal the mechanisms and function of different gooses testicular development at different stages of laying cycle.,2024,10.1016/j.psj.2024.104007,https://pubmed.ncbi.nlm.nih.gov/39106693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,39747468,"Comprehensive analysis of heat shock protein 110, 90, 70, 60 families and tumor immune microenvironment characterization in clear cell renal cell carcinoma.",2025,10.1038/s41598-024-84834-x,https://pubmed.ncbi.nlm.nih.gov/39747468/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,36921580,Parkinson's Disease as a Risk Factor for Prostate Adenocarcinoma: A Molecular Point of View.,2023,10.1159/000530088,https://pubmed.ncbi.nlm.nih.gov/36921580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,36012584,"Expression of TXNRD1, HSPA4L and ATP1B1 Genes Associated with the Freezability of Boar Sperm.",2022,10.3390/ijms23169320,https://pubmed.ncbi.nlm.nih.gov/36012584/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,30914484,Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo.,2019,10.1126/scisignal.aao7232,https://pubmed.ncbi.nlm.nih.gov/30914484/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,30637842,Decreased expression of heat shock protein A4L in spermatozoa is positively related to poor human sperm quality.,2019,10.1002/mrd.23113,https://pubmed.ncbi.nlm.nih.gov/30637842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,35066604,GIT1 is an untolerized autoantigen involved in immunologic disturbance of spermatogenesis.,2022,10.1007/s00418-021-02061-1,https://pubmed.ncbi.nlm.nih.gov/35066604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,38563097,Biosynthesis of Apigenin Glucosides in Engineered Corynebacterium glutamicum.,2024,10.4014/jmb.2401.01017,https://pubmed.ncbi.nlm.nih.gov/38563097/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,33894646,Heat shock protein A4L is a potent autoantigen for testicular autoimmunity in mice.,2021,10.1016/j.jri.2021.103318,https://pubmed.ncbi.nlm.nih.gov/33894646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,26952955,Expression and function of HSP110 family in mouse testis after vasectomy.,2017,10.4103/1008-682x.164197,https://pubmed.ncbi.nlm.nih.gov/26952955/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,34405404,miR-434 and miR-242 have a potential role in heat stress response in rainbow trout (Oncorhynchus mykiss).,2021,10.1111/jfb.14881,https://pubmed.ncbi.nlm.nih.gov/34405404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,32503176,Could the Heat Shock Proteins 70 Family Members Exacerbate the Immune Response in Multiple Sclerosis? An in Silico Study.,2020,10.3390/genes11060615,https://pubmed.ncbi.nlm.nih.gov/32503176/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,35401661,Genetic Basis for Resistance Against Viral Nervous Necrosis: GWAS and Potential of Genomic Prediction Explored in Farmed European Sea Bass (Dicentrarchus labrax).,2022,10.3389/fgene.2022.804584,https://pubmed.ncbi.nlm.nih.gov/35401661/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,37720575,Ginsenoside Rk1 inhibits HeLa cell proliferation through an endoplasmic reticulum signaling pathway.,2023,10.1016/j.jgr.2023.04.004,https://pubmed.ncbi.nlm.nih.gov/37720575/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,30875555,iTRAQ-based proteomics analysis reveals the deregulated proteins related to liver toxicity induced by melamine with or without cyanuric acid in mice.,2019,10.1016/j.ecoenv.2019.03.030,https://pubmed.ncbi.nlm.nih.gov/30875555/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,27114530,Extended survival of misfolded G85R SOD1-linked ALS mice by transgenic expression of chaperone Hsp110.,2016,10.1073/pnas.1604885113,https://pubmed.ncbi.nlm.nih.gov/27114530/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,32483666,Decoding social behaviors in a glycerol dependent bacterial consortium during Reactive Blue 28 degradation.,2020,10.1007/s42770-020-00303-3,https://pubmed.ncbi.nlm.nih.gov/32483666/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,17588478,"Identification of an overexpressed gene, HSPA4L, the product of which can provoke prevalent humoral immune responses in leukemia patients.",2007,10.1016/j.exphem.2007.03.015,https://pubmed.ncbi.nlm.nih.gov/17588478/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,23018186,Characterization of the constitutive pig ovary heat shock chaperone machinery and its response to acute thermal stress or to seasonal variations.,2012,10.1095/biolreprod.112.104018,https://pubmed.ncbi.nlm.nih.gov/23018186/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HSPA4L,ENSG00000164070,Unsafe,25798051,"Upregulation of heat shock proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in tumour tissues is associated with poor outcomes from HBV-related early-stage hepatocellular carcinoma.",2015,10.7150/ijms.10735,https://pubmed.ncbi.nlm.nih.gov/25798051/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,42773748,Expression GWAS and Differential Methylome Profiling Reveal Upstream Regulators of Drought Memory Genes in Arabidopsis thaliana.,2026,10.1111/pce.70914,https://pubmed.ncbi.nlm.nih.gov/42773748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,42450010,Loss of ASMT Function in Arabidopsis Affects Hormone Pathways and the Ability to Withstand Drought Stress.,2026,10.3390/ijms27135737,https://pubmed.ncbi.nlm.nih.gov/42450010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,40122789,Comprehensive characterization and diversity analysis of the HIS1 gene family in rice subpopulations for herbicide resistance.,2025,10.1186/s12870-025-06379-z,https://pubmed.ncbi.nlm.nih.gov/40122789/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,40507844,Exploring the Healing Powers of Histatins: From Oral Health to Therapeutics.,2025,10.3390/ijms26115019,https://pubmed.ncbi.nlm.nih.gov/40507844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,41673772,Genome-Edited Maize Expressing Two Native Genes Confers Broad-Spectrum Resistance to Northern Corn Leaf Blight.,2026,10.1111/mpp.70205,https://pubmed.ncbi.nlm.nih.gov/41673772/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,42015745,TaSRO1 recruits the histone deacetylase TaHIS1 to repress TaABI5 and fine-tune ABA signaling during seed dormancy release in wheat.,2026,10.1093/plcell/koag121,https://pubmed.ncbi.nlm.nih.gov/42015745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,39032670,Allergic fungal rhinosinusitis linked to other hyper-IgE syndromes through defective TH17 responses.,2024,10.1016/j.jaci.2024.06.022,https://pubmed.ncbi.nlm.nih.gov/39032670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,39201484,Comparison of Peptidomes Extracted from Healthy Tissue and Tumor Tissue of the Parotid Glands and Saliva Samples.,2024,10.3390/ijms25168799,https://pubmed.ncbi.nlm.nih.gov/39201484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,37889164,Photosynthetic Costs and Impact on Epidemiological Parameters Associated with Ht Resistance Genes in Maize Lines Infected with Exserohilum turcicum.,2024,10.1094/phyto-07-23-0247-r,https://pubmed.ncbi.nlm.nih.gov/37889164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,39396174,IN VITRO ANTICANCER ACTIVITY OF HISTATIN-1 COMBINATION WITH CISPLATIN IN HEAD AND NECK CANCER CELL LINES.,2024,10.15407/exp-oncology.2024.02.101,https://pubmed.ncbi.nlm.nih.gov/39396174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,35489730,"Association Between PD-L1 and Histatin1, 3 Expression in Advanced Head and Neck Squamous Cell Carcinoma.",2022,10.21873/anticanres.15747,https://pubmed.ncbi.nlm.nih.gov/35489730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,38433262,"Evolutionary and synteny analysis of HIS1, BADH2, GBSS1, and GBSS2 in rice: insights for effective introgression breeding strategies.",2024,10.1038/s41598-024-55581-w,https://pubmed.ncbi.nlm.nih.gov/38433262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,40956442,Multi-omics reveals glucose repression of citric acid catabolism in Pichia kudriavzevii.,2025,10.1007/s00253-025-13590-3,https://pubmed.ncbi.nlm.nih.gov/40956442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,37452022,A seven-transmembrane methyltransferase catalysing N-terminal histidine methylation of lytic polysaccharide monooxygenases.,2023,10.1038/s41467-023-39875-7,https://pubmed.ncbi.nlm.nih.gov/37452022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,41062549,A systematic comparison of CRISPR-Cas9 allele editing in Candida auris demonstrates unreliable cassette integration and effective episomal plasmid-based editing.,2025,10.1038/s41598-025-19115-2,https://pubmed.ncbi.nlm.nih.gov/41062549/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,35474141,Linker histone variant HIS1-3 and WRKY1 oppositely regulate salt stress tolerance in Arabidopsis.,2022,10.1093/plphys/kiac174,https://pubmed.ncbi.nlm.nih.gov/35474141/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,34521467,Expanding the toolbox: another auxotrophic marker for targeted gene integrations in Trichoderma reesei.,2021,10.1186/s40694-021-00116-5,https://pubmed.ncbi.nlm.nih.gov/34521467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,34608958,Catalytic promiscuity of rice 2-oxoglutarate/Fe(II)-dependent dioxygenases supports xenobiotic metabolism.,2021,10.1093/plphys/kiab293,https://pubmed.ncbi.nlm.nih.gov/34608958/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,35395133,Ectopic expression of a rice triketone dioxygenase gene confers mesotrione tolerance in soybean.,2022,10.1002/ps.6904,https://pubmed.ncbi.nlm.nih.gov/35395133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,33391321,Diversity of Expression Types of Ht Genes Conferring Resistance in Maize to Exserohilum turcicum.,2020,10.3389/fpls.2020.607850,https://pubmed.ncbi.nlm.nih.gov/33391321/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,37723773,Dynamic structural analysis-based epitope prediction of Exendin-4 in aqueous solution.,2023,10.1103/physreve.108.024403,https://pubmed.ncbi.nlm.nih.gov/37723773/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,39924164,Design of Histidine Sequence-Associated Tripeptide Sequences for Recognition of Copper Ions and Their Application to Live Cells.,2025,10.1002/bio.70095,https://pubmed.ncbi.nlm.nih.gov/39924164/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,35785376,Intermittent orthodromic capture of the earliest activation site during atrial pacing in a case with reentrant atrial tachycardia originating from the atrioventricular node vicinity.,2022,10.1002/joa3.12702,https://pubmed.ncbi.nlm.nih.gov/35785376/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,33415497,Exploring Natural Allelic Variations of the β-Triketone Herbicide Resistance Gene HIS1 for Application in indica Rice and Particularly in Two-Line Hybrid Rice.,2021,10.1186/s12284-020-00448-7,https://pubmed.ncbi.nlm.nih.gov/33415497/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,32734817,AHA/ACC-defined stage 1 hypertensive adults do not display cutaneous microvascular endothelial dysfunction.,2020,10.1152/ajpheart.00179.2020,https://pubmed.ncbi.nlm.nih.gov/32734817/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,32849670,Production of Herbicide-Sensitive Strain to Prevent Volunteer Rice Infestation Using a CRISPR-Cas9 Cytidine Deaminase Fusion.,2020,10.3389/fpls.2020.00925,https://pubmed.ncbi.nlm.nih.gov/32849670/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,33319847,Genome-wide association studies in tropical maize germplasm reveal novel and known genomic regions for resistance to Northern corn leaf blight.,2020,10.1038/s41598-020-78928-5,https://pubmed.ncbi.nlm.nih.gov/33319847/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,32436216,"Signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide.",2020,10.1111/bph.15134,https://pubmed.ncbi.nlm.nih.gov/32436216/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,30355670,Functional Mapping of Transcription Factor Grf10 That Regulates Adenine-Responsive and Filamentation Genes in Candida albicans.,2018,10.1128/msphere.00467-18,https://pubmed.ncbi.nlm.nih.gov/30355670/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,25674162,Recent Progress in the Use of Glucagon and Glucagon Receptor Antago-nists in the Treatment of Diabetes Mellitus.,2014,10.2174/1874104501408010028,https://pubmed.ncbi.nlm.nih.gov/25674162/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,15927871,Genotoxicity of stannous chloride in yeast and bacteria.,2005,10.1016/j.mrgentox.2005.03.003,https://pubmed.ncbi.nlm.nih.gov/15927871/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,10438744,"Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae.",1999,10.1128/jb.181.16.4774-4779.1999,https://pubmed.ncbi.nlm.nih.gov/10438744/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,3528759,"The isolation and characterization of ngm2, a mutation that affects nitrosoguanidine mutagenesis in yeast.",1986,10.1007/bf00330193,https://pubmed.ncbi.nlm.nih.gov/3528759/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,9257844,B cell responses to a peptide epitope: IV. Subtle sequence changes in flanking residues modulate immunogenicity.,1997,10.4049/jimmunol.159.4.1809,https://pubmed.ncbi.nlm.nih.gov/9257844/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,2547606,Properties of vasoactive-intestinal-peptide receptors and beta-adrenoceptors in the murine radiation leukemia-virus-induced lymphoma cell line BL/VL3.,1989,10.1111/j.1432-1033.1989.tb14922.x,https://pubmed.ncbi.nlm.nih.gov/2547606/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN1,ENSG00000126550,Unsafe,17503797,Tyrosine polysulfation of human salivary histatin 1. A post-translational modification specific of the submandibular gland.,2007,10.1021/pr0700706,https://pubmed.ncbi.nlm.nih.gov/17503797/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,42664892,A cross-platform validated biomarker signature for mucoepidermoid carcinoma identified by integrated WGCNA and machine learning.,2026,10.1016/j.compbiolchem.2026.109338,https://pubmed.ncbi.nlm.nih.gov/42664892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,41876383,The Cys2/His2-type zinc finger transcription factor CsZAT10 positively regulates Cucumis sativus resistance against Bemisia tabaci by activating the plant defense system.,2026,10.1002/ps.70747,https://pubmed.ncbi.nlm.nih.gov/41876383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,42895067,Integrative analysis reveals extensive interactions among C2H2 zinc finger proteins at chromatin loop anchors.,2026,10.1093/nar/gkag1004,https://pubmed.ncbi.nlm.nih.gov/42895067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,41135303,RPA-CRISPR-Cas12a/RPA-CRISPR-Cas12a-LFD: Two detection platforms for the rapid identification of five forensic body fluids.,2026,10.1016/j.fsigen.2025.103376,https://pubmed.ncbi.nlm.nih.gov/41135303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,42153578,20-Hydroxyecdysone primary response gene LmBlimp-1 controls locust molt and survival by regulating chitin metabolism.,2026,10.1002/ps.70944,https://pubmed.ncbi.nlm.nih.gov/42153578/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,42260296,"Apple ZAT11, a C2H2-type zinc finger protein, enhances resistance to Penicillium expansum by affecting jasmonic acid biosynthesis in apple.",2026,10.1111/nph.71312,https://pubmed.ncbi.nlm.nih.gov/42260296/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,40507844,Exploring the Healing Powers of Histatins: From Oral Health to Therapeutics.,2025,10.3390/ijms26115019,https://pubmed.ncbi.nlm.nih.gov/40507844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,41042447,Rice Transcription Factor HSTL Regulates Plant Height and Salt Stress Response by Modulating Gibberellin Homeostasis.,2025,10.1186/s12284-025-00851-y,https://pubmed.ncbi.nlm.nih.gov/41042447/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,41892231,"The Structure, Classification, Functional Diversity and Regulatory Mechanism of Plant C2H2 Transcription Factors.",2026,10.3390/biology15060471,https://pubmed.ncbi.nlm.nih.gov/41892231/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,39115578,"Characterization of the ZCTs, a subgroup of Cys2-His2 zinc finger transcription factors regulating alkaloid biosynthesis in Catharanthus roseus.",2024,10.1007/s00299-024-03295-8,https://pubmed.ncbi.nlm.nih.gov/39115578/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,40427698,Genome-Wide Identification and Cold Stress Response Mechanism of Barley Di19 Gene Family.,2025,10.3390/biology14050508,https://pubmed.ncbi.nlm.nih.gov/40427698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,41763554,ZFP151 enhances drought tolerance in rice through direct activation of NCED4 expression.,2026,10.1016/j.jgg.2026.02.022,https://pubmed.ncbi.nlm.nih.gov/41763554/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,39201484,Comparison of Peptidomes Extracted from Healthy Tissue and Tumor Tissue of the Parotid Glands and Saliva Samples.,2024,10.3390/ijms25168799,https://pubmed.ncbi.nlm.nih.gov/39201484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,42162812,Ecdysone-inducible SP transcription factor SPTF3L controls wing development by regulating cell proliferation and metabolic homeostasis in Locusta migratoria.,2026,10.1016/j.ibmb.2026.104587,https://pubmed.ncbi.nlm.nih.gov/42162812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,40562228,"The Cys2-His2 zinc finger transcription factor NsdC regulates hyphal branching, conidiation and mycelial pellet morphology in Aspergillus oryzae.",2025,10.1016/j.fgb.2025.104019,https://pubmed.ncbi.nlm.nih.gov/40562228/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,39981045,"TaZFP 23, a new Cys2/His2-type zinc-finger protein, is a regulator of wheat (&lt;i&gt;Triticum aestivum&lt;/i&gt; L.) growth and abiotic stresses.",2025,10.7717/peerj.18956,https://pubmed.ncbi.nlm.nih.gov/39981045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,38682454,PON3::LCN1 and HTN3::MSANTD3 Gene Fusions With NR4A3/NR4A2 Expression in Salivary Acinic Cell Carcinoma.,2024,10.1097/pas.0000000000002219,https://pubmed.ncbi.nlm.nih.gov/38682454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,35489730,"Association Between PD-L1 and Histatin1, 3 Expression in Advanced Head and Neck Squamous Cell Carcinoma.",2022,10.21873/anticanres.15747,https://pubmed.ncbi.nlm.nih.gov/35489730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,39263604,Krüppel-like factors family in health and disease.,2024,10.1002/mco2.723,https://pubmed.ncbi.nlm.nih.gov/39263604/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,39062521,Role of Specificity Protein 1 (SP1) in Cardiovascular Diseases: Pathological Mechanisms and Therapeutic Potentials.,2024,10.3390/biom14070807,https://pubmed.ncbi.nlm.nih.gov/39062521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,39924164,Design of Histidine Sequence-Associated Tripeptide Sequences for Recognition of Copper Ions and Their Application to Live Cells.,2025,10.1002/bio.70095,https://pubmed.ncbi.nlm.nih.gov/39924164/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,36834567,ZNF385A and ZNF346 Serve as Prognostic Biomarkers Associated with an Inflamed Immunosuppressive Tumor Microenvironment in Hepatocellular Carcinoma.,2023,10.3390/ijms24043155,https://pubmed.ncbi.nlm.nih.gov/36834567/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,39798569,DNA-binding affinity and specificity determine the phenotypic diversity in BCL11B-related disorders.,2025,10.1016/j.ajhg.2024.12.012,https://pubmed.ncbi.nlm.nih.gov/39798569/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,37952794,The role of renal denervation in cardiology and beyond: An updated comprehensive review and future directives.,2024,10.1016/j.cpcardiol.2023.102196,https://pubmed.ncbi.nlm.nih.gov/37952794/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,33920657,pH-Sensitive Chitosan Nanoparticles for Salivary Protein Delivery.,2021,10.3390/nano11041028,https://pubmed.ncbi.nlm.nih.gov/33920657/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,38816933,Coordinated control for the auricle asymmetric development by ZmIDD14 and ZmIDD15 fine-tune the high-density planting adaption in maize.,2024,10.1111/pbi.14382,https://pubmed.ncbi.nlm.nih.gov/38816933/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,38873116,Identification and expression of the Di19 gene family in response to abiotic stress in common bean (Phaseolus vulgaris L.).,2024,10.3389/fgene.2024.1401011,https://pubmed.ncbi.nlm.nih.gov/38873116/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,37511831,Genome Editing and Improvement of Abiotic Stress Tolerance in Crop Plants.,2023,10.3390/life13071456,https://pubmed.ncbi.nlm.nih.gov/37511831/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,35492028,KLF10 promotes nonalcoholic steatohepatitis progression through transcriptional activation of zDHHC7.,2022,10.15252/embr.202154229,https://pubmed.ncbi.nlm.nih.gov/35492028/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,33712084,Deciphering the functional role of EGR1 in Prostaglandin F2 alpha induced luteal regression applying CRISPR in corpus luteum of buffalo.,2021,10.1186/s40659-021-00333-7,https://pubmed.ncbi.nlm.nih.gov/33712084/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,27228432,"Renal denervation in treatment-resistant essential hypertension. A randomized, SHAM-controlled, double-blinded 24-h blood pressure-based trial.",2016,10.1097/hjh.0000000000000977,https://pubmed.ncbi.nlm.nih.gov/27228432/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,25866937,Direct protein delivery to mammalian cells using cell-permeable Cys2-His2 zinc-finger domains.,2015,10.3791/52814,https://pubmed.ncbi.nlm.nih.gov/25866937/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,27733093,Biomarker Discovery by Modeling Behçet's Disease with Patient-Specific Human Induced Pluripotent Stem Cells.,2017,10.1089/scd.2016.0181,https://pubmed.ncbi.nlm.nih.gov/27733093/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,26691387,"A novel Cys2/His2 zinc finger protein gene from sweetpotato, IbZFP1, is involved in salt and drought tolerance in transgenic Arabidopsis.",2016,10.1007/s00425-015-2443-9,https://pubmed.ncbi.nlm.nih.gov/26691387/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,27401554,The C2H2-ZF transcription factor Zfp335 recognizes two consensus motifs using separate zinc finger arrays.,2016,10.1101/gad.279406.116,https://pubmed.ncbi.nlm.nih.gov/27401554/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,28860938,Early growth response 2 and Egr3 are unique regulators in immune system.,2017,10.5114/ceji.2017.69363,https://pubmed.ncbi.nlm.nih.gov/28860938/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTN3,ENSG00000205649,Unsafe,25629384,Renal denervation: unde venis et quo vadis?,2015,10.1055/s-0034-1385526,https://pubmed.ncbi.nlm.nih.gov/25629384/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,41237175,"Comprehensive bioinformatic analysis of HTR7: A potential biomarker for diagnosis, survival, and immunotherapy in pan-cancer.",2025,10.1371/journal.pone.0335398,https://pubmed.ncbi.nlm.nih.gov/41237175/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,42242601,Jinhuang San alleviates plasma cell mastitis by restoring Th17/Treg balance through the HTR7/IL-6/JAK2/STAT3 axis.,2026,10.1016/j.jep.2026.121965,https://pubmed.ncbi.nlm.nih.gov/42242601/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,41866101,Ropivacaine attenuates cerebral ischemia-reperfusion injury in young male mice by reducing endothelial oxidative stress through activation of the Htr7/cAMP-PKA signaling.,2026,10.1016/j.jstrokecerebrovasdis.2026.108613,https://pubmed.ncbi.nlm.nih.gov/41866101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,42221301,Platelets Orchestrate a Neuroimmune Axis Driving Cutaneous Inflammation and Itch.,2026,10.34133/research.1294,https://pubmed.ncbi.nlm.nih.gov/42221301/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,40534501,Elevated 5-HTR7 deteriorates dysregulated megakaryocytopoiesis in immune thrombocytopenic purpura via upregulating the PKA/Orai1/ERK1/2 pathway.,2025,10.3324/haematol.2024.287287,https://pubmed.ncbi.nlm.nih.gov/40534501/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,42541488,"Sodium Overload-Related Molecular Subtypes and a Four-Gene Prognostic Signature Predict Survival, Immune Landscape, and Therapeutic Response in Acute Myeloid Leukemia.",2026,10.1002/mc.70158,https://pubmed.ncbi.nlm.nih.gov/42541488/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,42184065,Brain Serotonin Deficiency Impairs Ovarian Reserve Function via the Hypothalamic-Pituitary-Ovarian Axis.,2026,10.1007/s12264-026-01636-z,https://pubmed.ncbi.nlm.nih.gov/42184065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,42237266,Integrated analysis of miRNA and transcription factor gene expression profiles associated with anti-tuberculosis treatment responses.,2026,10.1186/s12879-026-13676-x,https://pubmed.ncbi.nlm.nih.gov/42237266/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,41308908,Impact of 5-HT7 receptor gene deletion on memory and affective behaviors in young and aged mice.,2026,10.1016/j.neuroscience.2025.11.035,https://pubmed.ncbi.nlm.nih.gov/41308908/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,42676783,Promising therapeutic efficacy of kolaviron against prenatal valproate-induced autism spectrum disorder.,2026,10.22038/ijbms.2026.94595.20399,https://pubmed.ncbi.nlm.nih.gov/42676783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,41614094,"Lack of striatal-enriched protein tyrosine phosphatase affected the serotonin system, behavior, and brain morphology in mice.",2025,10.3389/fpsyt.2025.1730197,https://pubmed.ncbi.nlm.nih.gov/41614094/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,39334486,Tryptophan-rich diet and its effects on Htr7+ Tregs in alleviating neuroinflammation and cognitive impairment induced by lipopolysaccharide.,2024,10.1186/s12974-024-03239-9,https://pubmed.ncbi.nlm.nih.gov/39334486/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,41301734,A Prognostic Neuromodulation-Related Gene Signature Identifies Immunomodulation and Tumour-Associated Hallmarks in Glioblastoma.,2025,10.3390/biomedicines13112640,https://pubmed.ncbi.nlm.nih.gov/41301734/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,42002767,"Genome-wide mapping of stress-responsive lncRNA, uc.104, reveals the chromatin-mediated regulation of stress and plasticity-related genes in the hippocampus of chronic restraint rats.",2026,10.1186/s13041-026-01304-3,https://pubmed.ncbi.nlm.nih.gov/42002767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,40901952,"Supplementing HIV-ART with cannabinoids increases serotonin, BHB, and Ahr signaling while reducing secondary bile acids and acylcholines.",2025,10.1126/sciadv.adw4021,https://pubmed.ncbi.nlm.nih.gov/40901952/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,41219608,The molecular footprint of the serotoninergic system in human glioblastoma cells.,2025,10.1007/s10735-025-10647-5,https://pubmed.ncbi.nlm.nih.gov/41219608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,40362261,Restraint Stress Disrupted Intestinal Homeostasis via 5-HT/HTR7/Wnt/β-Catenin/NF-kB Signaling.,2025,10.3390/ijms26094021,https://pubmed.ncbi.nlm.nih.gov/40362261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,41254172,Impact of pesticide diazinon on gastric cancer cell lines and the alteration of cholinergic and serotonergic pathway genes affecting cell proliferation.,2025,10.1038/s41598-025-24414-9,https://pubmed.ncbi.nlm.nih.gov/41254172/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,39027123,"Effect of amisulpride on the expression of serotonin receptors, neurotrophic factor BDNF and its receptors in mice with overexpression of the aggregation-prone [R406W] mutant tau protein.",2024,10.18699/vjgb-24-45,https://pubmed.ncbi.nlm.nih.gov/39027123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,39455564,Mouse enteric neurons control intestinal plasmacytoid dendritic cell function via serotonin-HTR7 signaling.,2024,10.1038/s41467-024-53545-2,https://pubmed.ncbi.nlm.nih.gov/39455564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,42913635,Lung neuroendocrine cancer induces immunosuppressive macrophages via serotonin to drive resistance to the T cell engager tarlatamab.,2026,10.1016/j.ccell.2026.09.016,https://pubmed.ncbi.nlm.nih.gov/42913635/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,41393793,"Network pharmacology, molecular docking and molecular dynamics simulation suggest CE-326597 as an antimalarial molecule.",2026,10.1007/s40203-025-00508-0,https://pubmed.ncbi.nlm.nih.gov/41393793/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,38686049,A genetic variant study of bortezomib-induced peripheral neuropathy in Chinese multiple myeloma patients.,2024,10.32604/or.2023.043922,https://pubmed.ncbi.nlm.nih.gov/38686049/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,40243950,Neurotransmitter 5-HT Further Promotes LL-37-Induced Rosacea-like Inflammation Through HTR3A.,2025,10.3390/ijms26073156,https://pubmed.ncbi.nlm.nih.gov/40243950/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,36335540,Targeting the brain 5-HT7 receptor to prevent hypomyelination in a rodent model of perinatal white matter injuries.,2023,10.1007/s00702-022-02556-8,https://pubmed.ncbi.nlm.nih.gov/36335540/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,40563358,Restorative Effects of Synbiotics on Colonic Ultrastructure and Oxidative Stress in Dogs with Chronic Enteropathy.,2025,10.3390/antiox14060727,https://pubmed.ncbi.nlm.nih.gov/40563358/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,38519480,Serotonergic modulation of vigilance states in zebrafish and mice.,2024,10.1038/s41467-024-47021-0,https://pubmed.ncbi.nlm.nih.gov/38519480/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,35090573,Serotonin receptors and their association with the immune system in the gastrointestinal tract of weaning piglets.,2022,10.1186/s40813-022-00250-5,https://pubmed.ncbi.nlm.nih.gov/35090573/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HTR7,ENSG00000148680,Unsafe,9084407,Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization.,1997,10.1046/j.1471-4159.1997.68041372.x,https://pubmed.ncbi.nlm.nih.gov/9084407/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,42688829,Development of humanized mouse models for the preclinical evaluation of NK cell-based therapies.,2026,10.3389/fimmu.2026.1887623,https://pubmed.ncbi.nlm.nih.gov/42688829/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,40598530,Hormonally upregulated neu tumor-associated kinase (HUNK) modulates gastric cancer progression through the regulation of cell homeostasis.,2025,10.1186/s12964-025-02329-2,https://pubmed.ncbi.nlm.nih.gov/40598530/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,40441033,Modulating hormonally upregulated neu-associated kinase (HUNK) activity in breast cancer: The development of HUNK inhibitors.,2025,10.1016/j.jpet.2025.103604,https://pubmed.ncbi.nlm.nih.gov/40441033/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,41487817,Bioinformatic Analysis of RNF43 and Its Co-expressors As Prognostic Biomarkers for Gastric Cancer.,2025,10.7759/cureus.98422,https://pubmed.ncbi.nlm.nih.gov/41487817/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,40371234,lncSLERT Promotes Liver Metastasis in Colorectal Cancer by Down-Regulating HUNK Expression via RBM15-Mediated m6A Modification.,2025,10.2147/ott.s514001,https://pubmed.ncbi.nlm.nih.gov/40371234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,38307028,Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer.,2024,10.1016/j.chembiol.2024.01.001,https://pubmed.ncbi.nlm.nih.gov/38307028/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,38846083,HUNK as a key regulator of tumor-associated macrophages in triple negative breast cancer.,2024,10.1080/2162402x.2024.2364382,https://pubmed.ncbi.nlm.nih.gov/38846083/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,36551828,HUNK Gene Alterations in Breast Cancer.,2022,10.3390/biomedicines10123072,https://pubmed.ncbi.nlm.nih.gov/36551828/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,37793312,Hypoxia inhibits HUNK kinase activity to induce epithelial-mesenchymal transition.,2023,10.1016/j.bbrc.2023.09.074,https://pubmed.ncbi.nlm.nih.gov/37793312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,41284867,"GWAS for behavioral traits in golden retrievers identifies genes implicated in human temperament, mental health, and cognition.",2025,10.1073/pnas.2421757122,https://pubmed.ncbi.nlm.nih.gov/41284867/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,37193711,HUNK inhibits epithelial-mesenchymal transition of CRC via direct phosphorylation of GEF-H1 and activating RhoA/LIMK-1/CFL-1.,2023,10.1038/s41419-023-05849-2,https://pubmed.ncbi.nlm.nih.gov/37193711/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,38430550,Autophagy markers are decreased in bone of osteoporotic patients: a monocentric comparative study.,2024,10.1093/ejendo/lvae017,https://pubmed.ncbi.nlm.nih.gov/38430550/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,32430012,Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells.,2020,10.1186/s13148-020-00839-z,https://pubmed.ncbi.nlm.nih.gov/32430012/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,32676513,HUNK Signaling in Metastatic Breast Cancer.,2020,10.18632/oncoscience.504,https://pubmed.ncbi.nlm.nih.gov/32676513/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,31597954,HUNK phosphorylates EGFR to regulate breast cancer metastasis.,2020,10.1038/s41388-019-1046-5,https://pubmed.ncbi.nlm.nih.gov/31597954/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,33958726,Correction: HUNK phosphorylates EGFR to regulate breast cancer metastasis.,2021,10.1038/s41388-021-01797-3,https://pubmed.ncbi.nlm.nih.gov/33958726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,30542510,"Staurosporine, an inhibitor of hormonally up-regulated neu-associated kinase.",2018,10.18632/oncotarget.26311,https://pubmed.ncbi.nlm.nih.gov/30542510/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,28189783,Hormonally up-regulated neu-associated kinase: A novel target for breast cancer progression.,2017,10.1016/j.phrs.2017.02.007,https://pubmed.ncbi.nlm.nih.gov/28189783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,31752345,HUNK Phosphorylates Rubicon to Support Autophagy.,2019,10.3390/ijms20225813,https://pubmed.ncbi.nlm.nih.gov/31752345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,25881306,Hunk/Mak-v is a negative regulator of intestinal cell proliferation.,2015,10.1186/s12885-015-1087-2,https://pubmed.ncbi.nlm.nih.gov/25881306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,34745101,International Prognostic Index-Based Immune Prognostic Model for Diffuse Large B-Cell Lymphoma.,2021,10.3389/fimmu.2021.732006,https://pubmed.ncbi.nlm.nih.gov/34745101/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HUNK,ENSG00000142149,Unsafe,9102242,[Septic arthritis in newborns and infants. Treatment of hip arthritis].,1996,,https://pubmed.ncbi.nlm.nih.gov/9102242/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,41197736,Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA.,2025,10.1016/j.jbc.2025.110886,https://pubmed.ncbi.nlm.nih.gov/41197736/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,38638566,Frequent loss of &lt;i&gt;FAM126A&lt;/i&gt; expression in colorectal cancer results in selective &lt;i&gt;FAM126B&lt;/i&gt; dependency.,2024,10.1016/j.isci.2024.109646,https://pubmed.ncbi.nlm.nih.gov/38638566/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,39705356,Molecular basis for plasma membrane recruitment of PI4KA by EFR3.,2024,10.1126/sciadv.adp6660,https://pubmed.ncbi.nlm.nih.gov/39705356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,41971655,The computational analysis of tumor cell sensitivity to supertarget deletion.,2026,10.18699/vjgb-26-02,https://pubmed.ncbi.nlm.nih.gov/41971655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,39216471,Structure of calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A.,2024,10.1016/j.str.2024.08.007,https://pubmed.ncbi.nlm.nih.gov/39216471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,40524177,"Discovery and validation of cell-free DNA methylation markers for specific diagnosis, differentiation from benign tumors, and prognosis of breast cancer.",2025,10.1186/s13058-025-02066-x,https://pubmed.ncbi.nlm.nih.gov/40524177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,42382508,Expanding the Phenotype and Genotype Spectrum of a Novel Mutation in Hypomyelinating Leukodystrophy-5 With a Review of the Literature on 42 Cases.,2025,10.32598/bcn.2024.6930.1,https://pubmed.ncbi.nlm.nih.gov/42382508/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,35513377,FAM126A interacted with ENO1 mediates proliferation and metastasis in pancreatic cancer via PI3K/AKT signaling pathway.,2022,10.1038/s41420-022-01047-9,https://pubmed.ncbi.nlm.nih.gov/35513377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,38891888,A Combination of Microarray-Based Profiling and Biocomputational Analysis Identified miR331-3p and hsa-let-7d-5p as Potential Biomarkers of Ulcerative Colitis Progression to Colorectal Cancer.,2024,10.3390/ijms25115699,https://pubmed.ncbi.nlm.nih.gov/38891888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,38230215,"n6-methyladenosine-modified circular RNA family with sequence similarity 126, member A affects cholesterol synthesis and malignant progression of prostate cancer cells by targeting microRNA-505-3p to mediate calnexin.",2024,10.7150/jca.89135,https://pubmed.ncbi.nlm.nih.gov/38230215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,20301737,Hypomyelination and Congenital Cataract,1993,,https://pubmed.ncbi.nlm.nih.gov/20301737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,34026180,Hypomyelination and Congenital Cataract: Identification of a Novel likely pathogenic c.414+1G>A in FAM126A gene Variant.,2021,10.1002/ccr3.4171,https://pubmed.ncbi.nlm.nih.gov/34026180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,34894559,"Hyccin/FAM126A deficiency reduces glial enrichment and axonal sheath, which are rescued by overexpression of a plasma membrane-targeting PI4KIIIα in Drosophila.",2022,10.1016/j.bbrc.2021.11.106,https://pubmed.ncbi.nlm.nih.gov/34894559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,34415310,"Biallelic PI4KA variants cause neurological, intestinal and immunological disease.",2021,10.1093/brain/awab313,https://pubmed.ncbi.nlm.nih.gov/34415310/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,34663815,Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane.,2021,10.1038/s41467-021-26326-4,https://pubmed.ncbi.nlm.nih.gov/34663815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,34975848,A Novel Homozygous TTC7A Missense Mutation Results in Familial Multiple Intestinal Atresia and Combined Immunodeficiency.,2021,10.3389/fimmu.2021.759308,https://pubmed.ncbi.nlm.nih.gov/34975848/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,34192786,"Hypomyelination and Congenital Cataract: Clinical, Imaging, and Genetic Findings in Three Tunisian Families and Literature Review.",2021,10.1055/s-0041-1728654,https://pubmed.ncbi.nlm.nih.gov/34192786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,26571211,The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane.,2016,10.1038/ncb3271,https://pubmed.ncbi.nlm.nih.gov/26571211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,24417797,Hypomyelinating leukodystrophy-associated missense mutant of FAM126A/hyccin/DRCTNNB1A aggregates in the endoplasmic reticulum.,2014,10.1016/j.jocn.2013.09.014,https://pubmed.ncbi.nlm.nih.gov/24417797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,33531944,Hypomyelination and Congenital Cataract: Three Siblings Presentation.,2020,10.4103/jpn.jpn_161_18,https://pubmed.ncbi.nlm.nih.gov/33531944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,30103315,TTC7 and Hyccin Regulate Neuronal Aβ42 Accumulation and its Associated Neural Deficits in Aβ42-Expressing Drosophila.,2018,10.3233/jad-170907,https://pubmed.ncbi.nlm.nih.gov/30103315/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYCC1,ENSG00000122591,Unsafe,10910037,"Isolation and characterization of a novel human gene, DRCTNNB1A, the expression of which is down-regulated by beta-catenin.",2000,,https://pubmed.ncbi.nlm.nih.gov/10910037/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,42888219,RNA sequencing significantly improves HYDIN diagnosis and defines the effects of common deletions in primary ciliary dyskinesia.,2026,10.1038/s41431-026-02243-2,https://pubmed.ncbi.nlm.nih.gov/42888219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,41969585,Whole-exome sequencing unveils novel potential gene mutations involved in primary renal small cell carcinoma.,2026,10.3892/ol.2026.15556,https://pubmed.ncbi.nlm.nih.gov/41969585/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,39850822,The relationship between HYDIN and fallopian tubal cilia loss in patients with epithelial ovarian cancer.,2024,10.3389/fonc.2024.1495753,https://pubmed.ncbi.nlm.nih.gov/39850822/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,41346656,Long-Read Sequencing as a Diagnostic Tool for Primary Ciliary Dyskinesia.,2025,10.1155/crig/5109434,https://pubmed.ncbi.nlm.nih.gov/41346656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,42200202,Comprehensive genomic profiling of neuroendocrine neoplasms of the colorectum.,2026,10.3389/fgene.2026.1792341,https://pubmed.ncbi.nlm.nih.gov/42200202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,41073067,Towards a practical tool to identify &lt;i&gt;HYDIN&lt;/i&gt; genotype using high-speed videomicroscopy.,2025,10.1136/thorax-2025-223584,https://pubmed.ncbi.nlm.nih.gov/41073067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,42420839,Consensus-based detection of aetiologic copy number variants for syndromic orofacial clefts utilising whole exome sequencing of case parent trios.,2026,10.1186/s12863-026-01466-y,https://pubmed.ncbi.nlm.nih.gov/42420839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,39291810,HYDIN variants cause primary ciliary dyskinesia in the Finnish population.,2024,10.1002/ppul.27267,https://pubmed.ncbi.nlm.nih.gov/39291810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,40473901,In situ structure of the mouse sperm central apparatus reveals mechanistic insights into asthenozoospermia.,2025,10.1038/s41422-025-01135-2,https://pubmed.ncbi.nlm.nih.gov/40473901/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,39579181,Hydin as the Candidate Master Sex Determination Gene in Channel Catfish (Ictalurus punctatus) and Its Epigenetic Regulation.,2024,10.1007/s10126-024-10387-9,https://pubmed.ncbi.nlm.nih.gov/39579181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,42072084,Transcriptomic Analysis of Fermented Chinese Chive Selectively Attenuating Deoxynivalenol-Induced Ovarian Toxicity in Mice.,2026,10.3390/antiox15040442,https://pubmed.ncbi.nlm.nih.gov/42072084/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,41115892,Identifying potential genetic biomarkers for sperm dysfunction through whole-genome sequencing.,2025,10.1038/s41598-025-23897-w,https://pubmed.ncbi.nlm.nih.gov/41115892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,38605126,"Combined approaches, including long-read sequencing, address the diagnostic challenge of HYDIN in primary ciliary dyskinesia.",2024,10.1038/s41431-024-01599-7,https://pubmed.ncbi.nlm.nih.gov/38605126/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,41375450,Genome-Wide Egg Hunt: Unhiding Candidate Genes for Egg Component Traits in Layers of an F&lt;sub&gt;2&lt;/sub&gt; Resource Population.,2025,10.3390/ani15233391,https://pubmed.ncbi.nlm.nih.gov/41375450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,38956598,Impact of aquaporin-4 and CD11c + microglia in the development of ependymal cells in the aqueduct: inferences to hydrocephalus.,2024,10.1186/s12987-024-00548-2,https://pubmed.ncbi.nlm.nih.gov/38956598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,40205238,Epigenetic profiles integrated with transcriptomic reveal the difference between COPD and PRISm in KOCOSS-NIH.,2025,10.1007/s10142-025-01593-2,https://pubmed.ncbi.nlm.nih.gov/40205238/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,36873931,"Pathogenic gene variants in CCDC39, CCDC40, RSPH1, RSPH9, HYDIN, and SPEF2 cause defects of sperm flagella composition and male infertility.",2023,10.3389/fgene.2023.1117821,https://pubmed.ncbi.nlm.nih.gov/36873931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,36742411,Novel HYDIN variants associated with male infertility in two Chinese families.,2023,10.3389/fendo.2023.1118841,https://pubmed.ncbi.nlm.nih.gov/36742411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,37595251,HYDIN mutation status as a potential predictor of immune checkpoint inhibitor efficacy in melanoma.,2023,10.18632/aging.204925,https://pubmed.ncbi.nlm.nih.gov/37595251/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,41913828,"Coexistence of Rheumatoid Arthritis, Cerebrovascular Disease, and Alzheimer's Disease: A Case Study With Genetic Insights.",2026,10.7759/cureus.104395,https://pubmed.ncbi.nlm.nih.gov/41913828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,38581027,Association study of FLT4 and HYDIN single nucleotide polymorphisms with atrial septal defect susceptibility in the Han Chinese population of Southwest China.,2024,10.1186/s13052-024-01630-z,https://pubmed.ncbi.nlm.nih.gov/38581027/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,39447114,Long-Term Lung Function and &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; Infection in Genotyped Primary Ciliary Dyskinesia.,2025,10.1513/annalsats.202404-340oc,https://pubmed.ncbi.nlm.nih.gov/39447114/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,39123171,Genomic landscape of hepatocellular carcinoma in Egyptian patients by whole exome sequencing.,2024,10.1186/s12920-024-01965-w,https://pubmed.ncbi.nlm.nih.gov/39123171/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,34395248,Immune Microenvironment Signatures as Biomarkers to Predict Early Recurrence of Stage Ia-b Lung Cancer.,2021,10.3389/fonc.2021.680287,https://pubmed.ncbi.nlm.nih.gov/34395248/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,34012644,Genome variation in colorectal cancer patient with liver metastasis measured by whole-exome sequencing.,2021,10.21037/jgo-21-9,https://pubmed.ncbi.nlm.nih.gov/34012644/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,30810461,"Comparative analyses of sperm DNA methylomes among human, mouse and cattle provide insights into epigenomic evolution and complex traits.",2019,10.1080/15592294.2019.1582217,https://pubmed.ncbi.nlm.nih.gov/30810461/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,17296796,Chlamydomonas reinhardtii hydin is a central pair protein required for flagellar motility.,2007,10.1083/jcb.200611115,https://pubmed.ncbi.nlm.nih.gov/17296796/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
HYDIN,ENSG00000157423,Unsafe,27486773,Integrated analysis miRNA and mRNA profiling in patients with severe oligozoospermia reveals miR-34c-3p downregulates PLCXD3 expression.,2016,10.18632/oncotarget.10947,https://pubmed.ncbi.nlm.nih.gov/27486773/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,42544324,Biallelic variants in IBA57 with multiple mitochondrial dysfunction syndrome 3.,2026,10.3389/fgene.2026.1815601,https://pubmed.ncbi.nlm.nih.gov/42544324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,41559004,Multiple Mitochondrial Dysfunction Syndrome Caused by IBA57 Gene Mutation: A Case Report and Literature Review.,2026,10.1002/mgg3.70200,https://pubmed.ncbi.nlm.nih.gov/41559004/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,42251905,Lactate-related diagnostic signature in rheumatoid arthritis: WGCNA and LASSO analysis with experimental validation.,2026,10.1016/j.imlet.2026.107200,https://pubmed.ncbi.nlm.nih.gov/42251905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,42523149,Novel blood lncRNA biomarkers associated with clinical severity and specific cognitive dimensions in Alzheimer's disease.,2026,10.1177/13872877261470430,https://pubmed.ncbi.nlm.nih.gov/42523149/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,41108822,"Establishment of human induced pluripotent stem cell line, NIMHi020-A from fibroblasts of a patient with IBA57 variant (p.Tyr113Cys).",2025,10.1016/j.scr.2025.103853,https://pubmed.ncbi.nlm.nih.gov/41108822/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,40602968,The first report of a successful birth by preimplantation genetic testing for leukodystrophy induced by IBA57 gene.,2025,10.1016/j.tjog.2025.01.007,https://pubmed.ncbi.nlm.nih.gov/40602968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,42529052,OMNIS: a spatially informed multi-omics deep-learning framework for tumor recurrence prediction and primary-metastatic tumor differentiation title page.,2026,10.3389/frai.2026.1817043,https://pubmed.ncbi.nlm.nih.gov/42529052/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,38923322,Clinical characteristics of a case of multiple mitochondrial dysfunction syndrome 3.,2024,10.1002/mgg3.2485,https://pubmed.ncbi.nlm.nih.gov/38923322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,39408793,Defects in the Maturation of Mitochondrial Iron-Sulfur Proteins: Biophysical Investigation of the MMDS3 Causing Gly104Cys Variant of IBA57.,2024,10.3390/ijms251910466,https://pubmed.ncbi.nlm.nih.gov/39408793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,37588046,A novel IBA57 variant is associated with mitochondrial iron-sulfur protein deficiency and necrotizing myelopathy in dogs.,2023,10.3389/fgene.2023.1190222,https://pubmed.ncbi.nlm.nih.gov/37588046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,41895631,Parental DEHP exposure induces sex-specific reproductive toxicity in zebrafish and behavioral deficits in unexposed offspring.,2026,10.1016/j.envpol.2026.128025,https://pubmed.ncbi.nlm.nih.gov/41895631/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,36385109,Systematic analysis of expression profiles and prognostic significance for MMDS-related iron-sulfur proteins in renal clear cell carcinoma.,2022,10.1038/s41598-022-22479-4,https://pubmed.ncbi.nlm.nih.gov/36385109/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,39227420,Phenotypic spectrum of iron-sulfur cluster assembly gene IBA57 mutations: c.286 T &gt; C identified as a hotspot mutation in Chinese patients with a stable natural history.,2025,10.1038/s10038-024-01291-0,https://pubmed.ncbi.nlm.nih.gov/39227420/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,37903659,"Clinical, radiological, biochemical and molecular characterization of a new case with multiple mitochondrial dysfunction syndrome due to IBA57: Lysine and tryptophan metabolites as potential biomarkers.",2023,10.1016/j.ymgme.2023.107710,https://pubmed.ncbi.nlm.nih.gov/37903659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,40642800,Isa2p is essential in &lt;i&gt;Saccharomyces cerevisiae&lt;/i&gt; for mitochondrial function and stress resistance by allowing Rip1p subunit assembly into cytochrome &lt;i&gt;bc&lt;/i&gt;&lt;sub&gt;1&lt;/sub&gt; complex.,2025,,https://pubmed.ncbi.nlm.nih.gov/40642800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,36075292,The iron-sulfur cluster assembly (ISC) protein Iba57 executes a tetrahydrofolate-independent function in mitochondrial [4Fe-4S] protein maturation.,2022,10.1016/j.jbc.2022.102465,https://pubmed.ncbi.nlm.nih.gov/36075292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,36360281,Multiple Mitochondrial Dysfunction Syndrome Type 3: A Likely Pathogenic Homozygous Variant Affecting a Patient of Cuban Descent and Literature Review.,2022,10.3390/genes13112044,https://pubmed.ncbi.nlm.nih.gov/36360281/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,36902159,Essentiality of the Escherichia coli YgfZ Protein for the In Vivo Thiomethylation of Ribosomal Protein S12 by the RimO Enzyme.,2023,10.3390/ijms24054728,https://pubmed.ncbi.nlm.nih.gov/36902159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,34709542,Novel IBA57 mutations in two chinese patients and literature review of multiple mitochondrial dysfunction syndrome.,2022,10.1007/s11011-021-00856-8,https://pubmed.ncbi.nlm.nih.gov/34709542/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,33890810,Unique and abnormal subependymal pseudocysts in a newborn with mitochondrial disease.,2021,10.1177/00368504211011873,https://pubmed.ncbi.nlm.nih.gov/33890810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,30258207,Expanding the phenotype of IBA57 mutations: related leukodystrophy can remain asymptomatic.,2018,10.1038/s10038-018-0516-x,https://pubmed.ncbi.nlm.nih.gov/30258207/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,35263578,CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH.,2022,10.1016/j.celrep.2022.110493,https://pubmed.ncbi.nlm.nih.gov/35263578/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,24028658,Reactive oxygen species production induced by ethanol in Saccharomyces cerevisiae increases because of a dysfunctional mitochondrial iron-sulfur cluster assembly system.,2013,10.1111/1567-1364.12090,https://pubmed.ncbi.nlm.nih.gov/24028658/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,20862391,Erythropoiesis and iron sulfur cluster biogenesis.,2010,10.1155/2010/329394,https://pubmed.ncbi.nlm.nih.gov/20862391/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,30838228,An Update on the Hereditary Spastic Paraplegias: New Genes and New Disease Models.,2015,10.1002/mdc3.12184,https://pubmed.ncbi.nlm.nih.gov/30838228/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IBA57,ENSG00000181873,Unsafe,23462291,Mutation of the iron-sulfur cluster assembly gene IBA57 causes severe myopathy and encephalopathy.,2013,10.1093/hmg/ddt107,https://pubmed.ncbi.nlm.nih.gov/23462291/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,40991444,&lt;i&gt;Inseparable/IER3IP1&lt;/i&gt; are essential for cytokinesis in &lt;i&gt;Drosophila&lt;/i&gt; neuroblasts and human cells.,2025,10.1073/pnas.2415361122,https://pubmed.ncbi.nlm.nih.gov/40991444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,42490363,Integrating Multi-Omics Mendelian Randomization and Functional Validation to Identify Novel Apoptosis Regulators in Follicular Lymphoma.,2026,10.1177/15330338261471599,https://pubmed.ncbi.nlm.nih.gov/42490363/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,41200581,"Microcephaly, Epilepsy, and Diabetes Syndrome 1: A Moroccan Case Report of Novel Compound Heterozygous &lt;i&gt;IER3IP1&lt;/i&gt; Mutations and Literature Review.",2025,10.2478/bjmg-2025-0006,https://pubmed.ncbi.nlm.nih.gov/41200581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,40112159,An Essential Role of IER3IP1 in β-Cell Development and Proinsulin Trafficking.,2025,10.2337/dbi24-0045,https://pubmed.ncbi.nlm.nih.gov/40112159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,39441964,IER3IP1 Mutations Cause Neonatal Diabetes Due to Impaired Proinsulin Trafficking.,2025,10.2337/db24-0119,https://pubmed.ncbi.nlm.nih.gov/39441964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,39115595,IER3IP1-mutations cause microcephaly by selective inhibition of ER-Golgi transport.,2024,10.1007/s00018-024-05386-x,https://pubmed.ncbi.nlm.nih.gov/39115595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,40924476,"Recessive TMEM167A variants cause neonatal diabetes, microcephaly, and epilepsy syndrome.",2025,10.1172/jci195756,https://pubmed.ncbi.nlm.nih.gov/40924476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,37934820,Essential requirement for IER3IP1 in B cell development.,2023,10.1073/pnas.2312810120,https://pubmed.ncbi.nlm.nih.gov/37934820/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,36322741,IER3IP1 is critical for maintaining glucose homeostasis through regulating the endoplasmic reticulum function and survival of β cells.,2022,10.1073/pnas.2204443119,https://pubmed.ncbi.nlm.nih.gov/36322741/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,36416459,"A New Variant of the IER3IP1 Gene: The First Case of Microcephaly, Epilepsy, and Diabetes Syndrome 1 from Turkey",2024,10.4274/jcrpe.galenos.2022.2022-8-12,https://pubmed.ncbi.nlm.nih.gov/36416459/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,37689631,"Safe use of the ketogenic diet in an infant with microcephaly, epilepsy, and diabetes syndrome: a case report.",2023,10.1186/s12887-023-04272-y,https://pubmed.ncbi.nlm.nih.gov/37689631/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,32886284,Changes in expressions of genes involved in the regulation of cellular processes in mucopolysaccharidoses as assessed by fibroblast culture-based transcriptomic analyses.,2020,10.1007/s11011-020-00614-2,https://pubmed.ncbi.nlm.nih.gov/32886284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,33122427,A human tissue screen identifies a regulator of ER secretion as a brain-size determinant.,2020,10.1126/science.abb5390,https://pubmed.ncbi.nlm.nih.gov/33122427/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,28915629,IER3IP1 deficiency leads to increased β-cell death and decreased β-cell proliferation.,2017,10.18632/oncotarget.18179,https://pubmed.ncbi.nlm.nih.gov/28915629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,21835305,"Microcephaly with simplified gyration, epilepsy, and infantile diabetes linked to inappropriate apoptosis of neural progenitors.",2011,10.1016/j.ajhg.2011.07.006,https://pubmed.ncbi.nlm.nih.gov/21835305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,24138066,"Microcephaly, epilepsy, and neonatal diabetes due to compound heterozygous mutations in IER3IP1: insights into the natural history of a rare disorder.",2014,10.1111/pedi.12086,https://pubmed.ncbi.nlm.nih.gov/24138066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,22991235,"A homozygous IER3IP1 mutation causes microcephaly with simplified gyral pattern, epilepsy, and permanent neonatal diabetes syndrome (MEDS).",2012,10.1002/ajmg.a.35583,https://pubmed.ncbi.nlm.nih.gov/22991235/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,34417961,Preliminary study of genome-wide association identifies novel susceptibility genes for serum mineral elements in the Chinese Han population.,2022,10.1007/s12011-021-02854-4,https://pubmed.ncbi.nlm.nih.gov/34417961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,19885854,Transcriptional regulation of IER3IP1 gene by tumor necrosis factor-alpha and Sp family proteins.,2010,10.1002/cbf.1613,https://pubmed.ncbi.nlm.nih.gov/19885854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,19951536,[Effect of IER3IP1 gene expression on the proliferation and erythroid differentiation of K562 cells].,2009,,https://pubmed.ncbi.nlm.nih.gov/19951536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IER3IP1,ENSG00000134049,Unsafe,15276200,"Cloning and characterization of a novel endoplasmic reticulum localized G-patch domain protein, IER3IP1.",2004,10.1016/j.gene.2004.04.033,https://pubmed.ncbi.nlm.nih.gov/15276200/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,42178579,FLNB and TTC26 regulate ciliary Hedgehog signaling to maintain intervertebral disc matrix homeostasis in adolescent idiopathic scoliosis.,2026,10.1186/s13059-026-04107-w,https://pubmed.ncbi.nlm.nih.gov/42178579/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,41352382,Genetic background influences the extent and severity of cilia-related congenital anomalies in Ift56/Ttc26 mutant mice.,2026,10.1016/j.ydbio.2025.12.003,https://pubmed.ncbi.nlm.nih.gov/41352382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,42006908,TTC26 scaffolds MINDY3-mediated RACK1 deubiquitination to drive osteoclastogenesis and pathological bone resorption.,2026,10.1016/j.jot.2026.101086,https://pubmed.ncbi.nlm.nih.gov/42006908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,40599775,"Identification of anoikis-related subtypes and a risk score prognosis model, the association with TME landscapes and therapeutic responses in hepatocellular carcinoma.",2025,10.3389/fimmu.2025.1602831,https://pubmed.ncbi.nlm.nih.gov/40599775/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,42124546,Identifying pleiotropic genes for backfat thickness and semen traits in pigs using GWAS summary data.,2026,10.1093/jas/skag150,https://pubmed.ncbi.nlm.nih.gov/42124546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,38135897,"A novel TTC26 variant in a patient with hexadactyly, pituitary stalk interruption, hepatopathy, nephropathy, and bilateral lip-palate cleft: A case report and expansion of the phenotype.",2024,10.1002/ajmg.a.63515,https://pubmed.ncbi.nlm.nih.gov/38135897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,35210288,Hop Mice Display Synchronous Hindlimb Locomotion and a Ventrally Fused Lumbar Spinal Cord Caused by a Point Mutation in Ttc26.,2022,10.1523/eneuro.0518-21.2022,https://pubmed.ncbi.nlm.nih.gov/35210288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,34177428,"Identification of the TTC26 Splice Variant in a Novel Complex Ciliopathy Syndrome with Biliary, Renal, Neurological, and Skeletal Manifestations.",2021,10.1159/000513829,https://pubmed.ncbi.nlm.nih.gov/34177428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,36273201,Biallelic mutations of TTC12 and TTC21B were identified in Chinese patients with multisystem ciliopathy syndromes.,2022,10.1186/s40246-022-00421-z,https://pubmed.ncbi.nlm.nih.gov/36273201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,36533556,Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants.,2022,10.1242/dmm.049568,https://pubmed.ncbi.nlm.nih.gov/36533556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,32617964,Pituitary stalk interruption syndrome broadens the clinical spectrum of the TTC26 ciliopathy.,2020,10.1111/cge.13805,https://pubmed.ncbi.nlm.nih.gov/32617964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,35530270,Construction of AP003469.4-miRNAs-mRNAs ceRNA network to reveal potential biomarkers for hepatocellular carcinoma.,2022,,https://pubmed.ncbi.nlm.nih.gov/35530270/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,28264835,IFT56 regulates vertebrate developmental patterning by maintaining IFTB complex integrity and ciliary microtubule architecture.,2017,10.1242/dev.143255,https://pubmed.ncbi.nlm.nih.gov/28264835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,31595528,Biallelic Mutations in Tetratricopeptide Repeat Domain 26 (Intraflagellar Transport 56) Cause Severe Biliary Ciliopathy in Humans.,2020,10.1002/hep.30982,https://pubmed.ncbi.nlm.nih.gov/31595528/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,27927754,Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E.,2017,10.1242/jcs.197004,https://pubmed.ncbi.nlm.nih.gov/27927754/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,22718903,Knockdown of ttc26 disrupts ciliogenesis of the photoreceptor cells and the pronephros in zebrafish.,2012,10.1091/mbc.e12-01-0019,https://pubmed.ncbi.nlm.nih.gov/22718903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,25340710,A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling.,2014,10.1371/journal.pgen.1004689,https://pubmed.ncbi.nlm.nih.gov/25340710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,26980730,Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex.,2016,10.1074/jbc.m116.713883,https://pubmed.ncbi.nlm.nih.gov/26980730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,28077622,Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46-IFT56 as well as on its nuclear localization signal.,2017,10.1091/mbc.e16-09-0648,https://pubmed.ncbi.nlm.nih.gov/28077622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,32381728,Exome sequencing analysis identifies frequent oligogenic involvement and FLNB variants in adolescent idiopathic scoliosis.,2020,10.1136/jmedgenet-2019-106411,https://pubmed.ncbi.nlm.nih.gov/32381728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT56,ENSG00000105948,Unsafe,28215051,(Pro)renin receptor (ATP6AP2) depletion arrests As4.1 cells in the G0/G1 phase thereby increasing formation of primary cilia.,2017,10.1111/jcmm.13069,https://pubmed.ncbi.nlm.nih.gov/28215051/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT70A,ENSG00000197557,Unsafe,42673838,Comprehensive bioinformatics analysis identifies candidate ciliogenesis-related genes preferentially associated with N0-stage lung squamous cell carcinoma.,2026,10.1016/j.compbiomed.2026.111902,https://pubmed.ncbi.nlm.nih.gov/42673838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT70A,ENSG00000197557,Unsafe,38074101,Paralog-specific TTC30 regulation of Sonic hedgehog signaling.,2023,10.3389/fmolb.2023.1268722,https://pubmed.ncbi.nlm.nih.gov/38074101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT70A,ENSG00000197557,Unsafe,34548398,Ttc30a affects tubulin modifications in a model for ciliary chondrodysplasia with polycystic kidney disease.,2021,10.1073/pnas.2106770118,https://pubmed.ncbi.nlm.nih.gov/34548398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT70A,ENSG00000197557,Unsafe,35885974,TTC30A and TTC30B Redundancy Protects IFT Complex B Integrity and Its Pivotal Role in Ciliogenesis.,2022,10.3390/genes13071191,https://pubmed.ncbi.nlm.nih.gov/35885974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT70A,ENSG00000197557,Unsafe,31735294,Bi-allelic Mutations in TTC29 Cause Male Subfertility with Asthenoteratospermia in Humans and Mice.,2019,10.1016/j.ajhg.2019.10.010,https://pubmed.ncbi.nlm.nih.gov/31735294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT70A,ENSG00000197557,Unsafe,29654116,Robust interaction of IFT70 with IFT52-IFT88 in the IFT-B complex is required for ciliogenesis.,2018,10.1242/bio.033241,https://pubmed.ncbi.nlm.nih.gov/29654116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT70B,ENSG00000196659,Unsafe,42673838,Comprehensive bioinformatics analysis identifies candidate ciliogenesis-related genes preferentially associated with N0-stage lung squamous cell carcinoma.,2026,10.1016/j.compbiomed.2026.111902,https://pubmed.ncbi.nlm.nih.gov/42673838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT70B,ENSG00000196659,Unsafe,41786235,HOXD12 a candidate gene for a novel form of synpolydactyly.,2026,10.1016/j.bone.2026.117842,https://pubmed.ncbi.nlm.nih.gov/41786235/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT70B,ENSG00000196659,Unsafe,38074101,Paralog-specific TTC30 regulation of Sonic hedgehog signaling.,2023,10.3389/fmolb.2023.1268722,https://pubmed.ncbi.nlm.nih.gov/38074101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT70B,ENSG00000196659,Unsafe,35885974,TTC30A and TTC30B Redundancy Protects IFT Complex B Integrity and Its Pivotal Role in Ciliogenesis.,2022,10.3390/genes13071191,https://pubmed.ncbi.nlm.nih.gov/35885974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT70B,ENSG00000196659,Unsafe,31306809,A rare TTC30B variant is identified as a candidate for synpolydactyly in a Chinese pedigree.,2019,10.1016/j.bone.2019.07.012,https://pubmed.ncbi.nlm.nih.gov/31306809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT70B,ENSG00000196659,Unsafe,23810713,Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17.,2013,10.1016/j.yexcr.2013.06.010,https://pubmed.ncbi.nlm.nih.gov/23810713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT70B,ENSG00000196659,Unsafe,29654116,Robust interaction of IFT70 with IFT52-IFT88 in the IFT-B complex is required for ciliogenesis.,2018,10.1242/bio.033241,https://pubmed.ncbi.nlm.nih.gov/29654116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IFT70B,ENSG00000196659,Unsafe,21737642,Etomidate induces cytotoxic effects and gene expression in a murine leukemia macrophage cell line (RAW264.7).,2011,,https://pubmed.ncbi.nlm.nih.gov/21737642/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42814409,ZBP1-mediated Treg cell dysfunction exacerbates neuroimmune dysregulation in Alzheimer's disease under metabolic stress.,2026,10.1002/alz.71896,https://pubmed.ncbi.nlm.nih.gov/42814409/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42653476,"ZBP1 in Neuroinflammation and Neurodegeneration: Z-Nucleic-Acid Sensing, RHIM Signalling and Therapeutic Targeting.",2026,10.3390/ijms27167478,https://pubmed.ncbi.nlm.nih.gov/42653476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42478124,SERPINE1 Alternative Polyadenylation Influences Gastric Cancer Prognosis via N6-Methyladenosine Modification.,2026,10.1111/cas.70464,https://pubmed.ncbi.nlm.nih.gov/42478124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42311118,Biological consequences of Z-nucleic acid sensing by ZBP1 and ADAR1.,2026,10.1080/15476286.2026.2691476,https://pubmed.ncbi.nlm.nih.gov/42311118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42905946,ADAR1 Inhibits ZBP1-Driven Neuronal Necroptosis After Intracerebral Hemorrhage.,2026,10.1096/fj.202504806rrrr,https://pubmed.ncbi.nlm.nih.gov/42905946/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42712988,TSG From &lt;i&gt;Polygonum multiflorum&lt;/i&gt; Thunb. Attenuates Experimental Premature Ovarian Insufficiency in Association With Reduced ZBP1/PANoptosis Signaling.,2026,10.1002/fsn3.72347,https://pubmed.ncbi.nlm.nih.gov/42712988/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42782762,METTL3/IGF2BP1 Axis Orchestrates m6A-Dependent NCAM1 Preservation to Combat Age-Related Cognitive Decline.,2026,10.3390/cells15181662,https://pubmed.ncbi.nlm.nih.gov/42782762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42847477,Exosomal let-7c-5p From AMI Patient Plasma Modulates Neuronal PANoptosis via ZBP1 In Vitro.,2026,10.1002/cbf.70318,https://pubmed.ncbi.nlm.nih.gov/42847477/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42571453,ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt;-induced sepsis.,2026,10.1016/j.mmr.2026.100059,https://pubmed.ncbi.nlm.nih.gov/42571453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42445387,METTL3- and IGF2BP1-associated m6A regulation of FADS2 contributes to lipid droplet accumulation and malignant progression in non-small cell lung cancer.,2026,10.21037/tcr-2026-1-0380,https://pubmed.ncbi.nlm.nih.gov/42445387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42261838,KRT14 Drives Basal Muscle-Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and Stabilizing IGF2BP1.,2026,10.1002/advs.75900,https://pubmed.ncbi.nlm.nih.gov/42261838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42460020,Hypoglycemia aggravates cognitive degeneration by activating endothelial ZBP1-mediated PANoptosis in type 2 diabetic mice.,2026,10.3389/fphar.2026.1825677,https://pubmed.ncbi.nlm.nih.gov/42460020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42436309,Human ZBP1 is a potent inducer of cell death through mechanisms divergent from mouse ZBP1.,2026,10.1038/s44319-026-00866-6,https://pubmed.ncbi.nlm.nih.gov/42436309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42273694,Emapunil attenuates ulcerative colitis by suppressing Z-DNA binding protein 1 driven pyroptosis and pro-inflammatory polarization in macrophages.,2026,10.3389/fimmu.2026.1813664,https://pubmed.ncbi.nlm.nih.gov/42273694/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42658872,HDAC2 restrains IGF2BP1-associated m6A dysregulation in cervical cancer immunotherapy resistance.,2026,10.1371/journal.pone.0355606,https://pubmed.ncbi.nlm.nih.gov/42658872/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42725716,Helicobacter pylori-Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis.,2026,10.1002/advs.77677,https://pubmed.ncbi.nlm.nih.gov/42725716/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42465019,IGF2BP1 orchestrates glycolytic reprogramming via HK2 to accelerate hepatocellular carcinoma malignancy.,2026,10.62347/ezps5229,https://pubmed.ncbi.nlm.nih.gov/42465019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42362538,ZBP1-driven pyroptosis-associated alveolar macrophages exacerbate epithelial dysfunction in sepsis.,2026,10.1038/s41419-026-09043-y,https://pubmed.ncbi.nlm.nih.gov/42362538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42152061,Lnc RNA GAPLINC affects triple-negative breast cancer progression through the miR-331-3p/IGF2BP1 axis.,2026,10.1186/s12957-026-04387-3,https://pubmed.ncbi.nlm.nih.gov/42152061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42570417,Novel mitophagy activator TJ0113 restricts cytosolic mtDNA to suppress ZBP1-driven inflammation in acute lung injury.,2026,10.1016/j.redox.2026.104337,https://pubmed.ncbi.nlm.nih.gov/42570417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42800308,Tumour-associated dsRNA accumulation and innate immune activation: mechanistic basis and therapeutic strategies.,2026,10.1016/j.ebiom.2026.106493,https://pubmed.ncbi.nlm.nih.gov/42800308/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42581605,PCAT6 Regulates IGF2BP1/PD-L1 to Promote Immune Escape in Breast Cancer.,2026,10.1002/jgm.70105,https://pubmed.ncbi.nlm.nih.gov/42581605/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42097226,Delivery of a ZBP1 agonist enhances radiotherapy-induced antitumour immunity in hepatocellular carcinoma.,2026,10.1016/j.jconrel.2026.114991,https://pubmed.ncbi.nlm.nih.gov/42097226/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42350387,KAT2A-IGF2BP1-CXCL2 axis in the high lactate tumor microenvironment facilitates resistance to anti-PD-1 therapy in lung adenocarcinoma by recruiting myeloid-derived suppressor cells.,2026,10.1038/s41419-026-09018-z,https://pubmed.ncbi.nlm.nih.gov/42350387/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42853659,IGF2BP1 in 17q-gain cooperates with MYCN to regulate purine biosynthesis and immunotherapy efficacy in neuroblastoma.,2026,10.1073/pnas.2524540123,https://pubmed.ncbi.nlm.nih.gov/42853659/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42873377,ZBP1 at the Interface of Nucleic-Acid Stress and Inflammatory Cell Death After Intracerebral Hemorrhage: A Hypothesis-Driven Overview.,2026,10.1007/s11064-026-04921-5,https://pubmed.ncbi.nlm.nih.gov/42873377/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42189863,ZBP1 Drives CD8+ T cell-mediated anti-tumor immunity in head and neck squamous cell carcinoma.,2026,10.1371/journal.pgen.1012107,https://pubmed.ncbi.nlm.nih.gov/42189863/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,41328513,"IGF2BP1 fosters an immunosuppressive tumor microenvironment in high-risk neuroblastoma, contributing to their resistance to immunotherapy.",2025,10.1080/2162402x.2025.2584408,https://pubmed.ncbi.nlm.nih.gov/41328513/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42840615,ZBP1 and IFI16: novel innate sensors and inflammation regulation under infection stress.,2026,10.3389/fimmu.2026.1869593,https://pubmed.ncbi.nlm.nih.gov/42840615/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42504531,ZC3H13-mediated m6A stabilization of CCND1 promotes malignant progression and is associated with poor anti-PD-1 response in HNSCC.,2026,10.1002/ctm2.70750,https://pubmed.ncbi.nlm.nih.gov/42504531/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42061147,Activating ZBP1-centered PANoptosis and a collaborative innate-adaptive immune response sensitizes glioblastoma to PD-1 blockade.,2026,10.1016/j.drup.2026.101395,https://pubmed.ncbi.nlm.nih.gov/42061147/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42140461,"Mechanistic insights and regulatory strategies of ZBP1 in tumorigenesis, progression, and cancer therapy.",2026,10.1016/j.critrevonc.2026.105379,https://pubmed.ncbi.nlm.nih.gov/42140461/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42107984,KCTD10 weakens m6A modification of IL-11 in a ubiquitin-dependent manner to repress tumour immune escape in lung adenocarcinoma.,2026,10.1111/bph.70490,https://pubmed.ncbi.nlm.nih.gov/42107984/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42467537,PANoptosis and Immune Remodeling in the Tumor Microenvironment.,2026,10.1096/fj.202601211r,https://pubmed.ncbi.nlm.nih.gov/42467537/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42780332,Neobractatin mediated ZBP1 induces PANoptosis of xenografted breast tumors.,2026,10.3389/fphar.2026.1913482,https://pubmed.ncbi.nlm.nih.gov/42780332/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,40966083,ZBP1 pathway promotes tumor immunogenicity in the combination of anti-HER2 therapy and epigenetic therapy.,2025,10.1016/j.celrep.2025.116314,https://pubmed.ncbi.nlm.nih.gov/40966083/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,42573560,Ferroptosis Suppression by the M&lt;sup&gt;6&lt;/sup&gt;A Reader IGF2BP1 Underlies Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma.,2026,10.1002/advs.77048,https://pubmed.ncbi.nlm.nih.gov/42573560/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,17255263,Increased expression of insulin-like growth factor-II messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer.,2007,10.1158/1078-0432.ccr-06-1297,https://pubmed.ncbi.nlm.nih.gov/17255263/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,16049158,Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer.,2005,10.1530/rep.1.00664,https://pubmed.ncbi.nlm.nih.gov/16049158/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,12921532,Nuclear transit of human zipcode-binding protein IMP1.,2003,10.1042/bj20030943,https://pubmed.ncbi.nlm.nih.gov/12921532/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP1,ENSG00000159217,Unsafe,9891060,A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development.,1999,10.1128/mcb.19.2.1262,https://pubmed.ncbi.nlm.nih.gov/9891060/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42567885,IGF2BP3-mediated regulation of the RNA isoform and modification landscape in pancreatic cancer.,2026,10.1038/s41388-026-03933-3,https://pubmed.ncbi.nlm.nih.gov/42567885/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,41989644,Unknotting the Role of circRNAs and IGF2BP3 in Alzheimer's Disease.,2026,10.1007/s10571-026-01724-8,https://pubmed.ncbi.nlm.nih.gov/41989644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42775431,A Metabolic-Epigenetic Axis of AARS1/IGF2BP3-K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence.,2026,10.1002/advs.77757,https://pubmed.ncbi.nlm.nih.gov/42775431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,41748276,Testing insulin-like growth factor messenger RNA-binding protein 3 as a surrogate immunohistochemical marker for indeterminate thyroid nodules with THADA fusion in both cytologic and surgical specimens.,2026,10.1002/cncy.70076,https://pubmed.ncbi.nlm.nih.gov/41748276/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42277127,Circulating IGF2BP3 enables risk stratification and predicts treatment response in Ewing sarcoma.,2026,10.1038/s41598-026-55275-5,https://pubmed.ncbi.nlm.nih.gov/42277127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42277199,IGF2BP3 promotes epithelial ovarian cancer progression by regulating FASN expression.,2026,10.1038/s41598-026-57059-3,https://pubmed.ncbi.nlm.nih.gov/42277199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42780509,IGF2BP3 remodels RISC occupancy to control microRNA targeting in leukemia.,2026,10.1093/narcan/zcag025,https://pubmed.ncbi.nlm.nih.gov/42780509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42340494,IGF2BP3 promotes glycolysis of osteosarcoma stem cells by reading RNA m⁶A to stabilize ENO1 and promote malignant biological behavior of osteosarcoma.,2026,10.1007/s10565-026-10218-8,https://pubmed.ncbi.nlm.nih.gov/42340494/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42589647,Targeting IGF2BP3 in Cancer: From Molecular Structure and Biology to Early Drug Discovery.,2026,10.3390/ijms27156992,https://pubmed.ncbi.nlm.nih.gov/42589647/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42658558,Pre-Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair.,2026,10.1002/advs.202522170,https://pubmed.ncbi.nlm.nih.gov/42658558/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42180918,IGF2BP3 promotes immune evasion and predicts poor prognosis in head and neck squamous cell carcinoma.,2026,10.21037/tcr-2025-1-2742,https://pubmed.ncbi.nlm.nih.gov/42180918/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42491749,IGF2BP3 is essential for the growth heterogeneity of colorectal adenoma cells by regulating MYC.,2026,10.1016/j.isci.2026.116535,https://pubmed.ncbi.nlm.nih.gov/42491749/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,41913519,Multiple Roles of Protamine Kinase SRPK1 and Phosphatase PP1γ in Sperm Development.,2026,10.1002/pmic.70121,https://pubmed.ncbi.nlm.nih.gov/41913519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42566145,IGF2BP3 promotes early angiogenesis in pulmonary fibrosis by stabilizing HIF-1α.,2026,10.1007/s11010-026-05684-x,https://pubmed.ncbi.nlm.nih.gov/42566145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42068022,IGF2BP3 promotes gastric cancer progression by inhibiting ferroptosis through ETV4-mediated regulation of GCH1.,2026,10.1080/15384047.2026.2664967,https://pubmed.ncbi.nlm.nih.gov/42068022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42554930,m&lt;sup&gt;6&lt;/sup&gt;A-Mediated Stabilization of S100A10 mRNA by IGF2BP3 Aggravates Environmental Cigarette Smoke-Induced Asthma in Children.,2026,10.1007/s12010-026-05863-y,https://pubmed.ncbi.nlm.nih.gov/42554930/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42449704,MKRN2-Mediated Degradation of IGF2BP3 Suppresses MYC and Enhances CDK4/6 Inhibitor Sensitivity in Bladder Cancer.,2026,10.3390/cancers18132164,https://pubmed.ncbi.nlm.nih.gov/42449704/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42618981,IGF2BP3 Overexpression Accelerates Osteoarthritis Progression by Promoting Glycolysis via m&lt;sup&gt;6&lt;/sup&gt;A-Dependent Stabilization of ECM1 mRNA.,2026,10.1002/kjm2.70280,https://pubmed.ncbi.nlm.nih.gov/42618981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42893454,HECTD1 Directs HIF-1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis.,2026,10.1002/advs.78339,https://pubmed.ncbi.nlm.nih.gov/42893454/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42631825,ARAP3 Facilitates Glioma Progression via IGF2BP3-Mediated m6A Modification Stabilization.,2026,10.1007/s12013-026-02135-8,https://pubmed.ncbi.nlm.nih.gov/42631825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42592954,IGF2BP3-Mediated m6A Modification of OLR1 mRNA Promotes Immune Evasion in CRC via the PI3K/AKT/mTOR Pathway.,2026,10.1097/cji.0000000000000613,https://pubmed.ncbi.nlm.nih.gov/42592954/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42638562,The Role of IGF2BP3-Mediated Immune Response Activation in Enhancing Immunotherapy of Koumine for Gastric Cancer.,2026,10.1111/cas.70514,https://pubmed.ncbi.nlm.nih.gov/42638562/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42491134,Epitranscriptomic regulation by m6A in immunity and autoimmune disorders: emerging mechanisms and clinical perspectives.,2026,10.3389/fimmu.2026.1887190,https://pubmed.ncbi.nlm.nih.gov/42491134/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,41634702,The molecular mechanism of IGF2BP3 promoting the malignant progression of lung cancer.,2026,10.1186/s12935-026-04217-2,https://pubmed.ncbi.nlm.nih.gov/41634702/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,41491528,USP5 inhibition stimulates immunogenic ferroptosis that enhances immunotherapy in diffuse large B-cell lymphoma.,2026,10.1186/s12964-025-02617-x,https://pubmed.ncbi.nlm.nih.gov/41491528/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,41579989,RBM15/IGF2BP3 promotes immune escape in bladder cancer by enhancing m6A modification of PFKFB4.,2026,10.1016/j.ijbiomac.2026.150142,https://pubmed.ncbi.nlm.nih.gov/41579989/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,40801655,IGF2BP3 as a Novel Prognostic Biomarker and Therapeutic Target in Lung Adenocarcinoma.,2025,10.3390/cells14151222,https://pubmed.ncbi.nlm.nih.gov/40801655/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42525957,KRAS Mutations Reprogram RNA m6A Modifications to Drive CD73-Dependent Immune Evasion in Colorectal Cancer.,2026,10.1158/0008-5472.can-26-0403,https://pubmed.ncbi.nlm.nih.gov/42525957/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,41993588,Single-cell and spatial dissection of IGF2BP3-driven endothelial reprogramming underlying microvascular invasion in hepatocellular carcinoma.,2026,10.3389/fphar.2026.1781301,https://pubmed.ncbi.nlm.nih.gov/41993588/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42436798,Prognostic and immunological implications of a mitophagy-associated gene signature in bladder cancer.,2026,10.21037/tau-2026-1-0147,https://pubmed.ncbi.nlm.nih.gov/42436798/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,42157936,METTL3-IGF2BP3 as a glucose sensor in hyperglycemic microenvironment promotes tumorigenesis and glycolysis.,2026,10.7150/ijbs.125135,https://pubmed.ncbi.nlm.nih.gov/42157936/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,41702895,Exogenous Epstein-Barr virus nuclear antigen 1 induces ADAR1-driven tumor resistance against immunotherapy.,2026,10.1038/s41392-026-02574-y,https://pubmed.ncbi.nlm.nih.gov/41702895/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,41038069,PARK7-driven IGF2BP3-K76 lactylation mediates ferroptosis and HAIC resistance in hepatocellular carcinoma.,2025,10.1016/j.redox.2025.103869,https://pubmed.ncbi.nlm.nih.gov/41038069/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,17192788,IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression.,2007,10.1038/modpathol.3800735,https://pubmed.ncbi.nlm.nih.gov/17192788/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,16814207,Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study.,2006,10.1016/s1470-2045(06)70732-x,https://pubmed.ncbi.nlm.nih.gov/16814207/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,16049158,Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer.,2005,10.1530/rep.1.00664,https://pubmed.ncbi.nlm.nih.gov/16049158/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,15644775,KOC (K homology domain containing protein overexpressed in cancer): a novel molecular marker that distinguishes between benign and malignant lesions of the pancreas.,2005,10.1097/01.pas.0000149688.98333.54,https://pubmed.ncbi.nlm.nih.gov/15644775/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,12161597,"Characterisation of the growth regulating gene IMP3, a candidate for Silver-Russell syndrome.",2002,10.1136/jmg.39.8.575,https://pubmed.ncbi.nlm.nih.gov/12161597/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,10525192,Expression of the highly conserved RNA binding protein KOC in embryogenesis.,1999,10.1016/s0925-4773(99)00160-4,https://pubmed.ncbi.nlm.nih.gov/10525192/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,9891060,A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development.,1999,10.1128/mcb.19.2.1262,https://pubmed.ncbi.nlm.nih.gov/9891060/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGF2BP3,ENSG00000136231,Unsafe,9178771,Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein.,1997,10.1038/sj.onc.1201110,https://pubmed.ncbi.nlm.nih.gov/9178771/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,39141178,Prognostic Value of Insulin Growth Factor-Like Receptor 1 (IGFLR1) in Stage II and III Colorectal Cancer and Its Association with Immune Cell Infiltration.,2025,10.1007/s12010-024-05006-1,https://pubmed.ncbi.nlm.nih.gov/39141178/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,41850335,Genome-wide meta-analysis in lichen sclerosus identifies 14 genomic risk loci.,2026,10.1093/bjd/ljag088,https://pubmed.ncbi.nlm.nih.gov/41850335/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,42396560,Matched embryo-endometrium RNA-seq reveals coordinated but asymmetric transcriptomic reprogramming at the onset of early equine pregnancy.,2026,10.3389/fcell.2026.1840498,https://pubmed.ncbi.nlm.nih.gov/42396560/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,40873572,Combined single-cell RNA-seq and bulk RNA-seq construction of M2 TAMs signature for predicting HNSCC prognosis and immunotherapy.,2025,10.3389/fimmu.2025.1620931,https://pubmed.ncbi.nlm.nih.gov/40873572/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,40597402,Exploring the impact of coffee consumption and caffeine intake on cognitive performance in older adults: a comprehensive analysis using NHANES data and gene correlation analysis.,2025,10.1186/s12937-025-01173-x,https://pubmed.ncbi.nlm.nih.gov/40597402/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,33324675,IGFLR1 as a Novel Prognostic Biomarker in Clear Cell Renal Cell Cancer Correlating With Immune Infiltrates.,2020,10.3389/fmolb.2020.565173,https://pubmed.ncbi.nlm.nih.gov/33324675/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,37396042,The diagnostic significance of the ZNF gene family in pancreatic cancer: a bioinformatics and experimental study.,2023,10.3389/fgene.2023.1089023,https://pubmed.ncbi.nlm.nih.gov/37396042/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,39052598,Prostaglandin D2 receptor 2 downstream signaling and modulation of type 2 innate lymphoid cells from patients with asthma.,2024,10.1371/journal.pone.0307750,https://pubmed.ncbi.nlm.nih.gov/39052598/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,39109335,Deciphering the genomic insights into the coexistence of congenital scoliosis and congenital anomalies of the kidney and urinary tract.,2024,10.3389/fgene.2024.1399604,https://pubmed.ncbi.nlm.nih.gov/39109335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,34306592,Integrated Analysis of the Roles of RNA Binding Proteins and Their Prognostic Value in Clear Cell Renal Cell Carcinoma.,2021,10.1155/2021/5568411,https://pubmed.ncbi.nlm.nih.gov/34306592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,35513791,Construction and validation of a prognostic model of RNA binding proteins in clear cell renal carcinoma.,2022,10.1186/s12882-022-02801-y,https://pubmed.ncbi.nlm.nih.gov/35513791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,21454693,"Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1.",2011,10.1074/jbc.m111.224626,https://pubmed.ncbi.nlm.nih.gov/21454693/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,34445339,Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin.,2021,10.3390/ijms22168634,https://pubmed.ncbi.nlm.nih.gov/34445339/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,35748966,LncRNA Pnky Positively Regulates Neural Stem Cell Migration by Modulating mRNA Splicing and Export of Target Genes.,2023,10.1007/s10571-022-01241-4,https://pubmed.ncbi.nlm.nih.gov/35748966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,37143720,Identification of bicalutamide resistance-related genes and prognosis prediction in patients with prostate cancer.,2023,10.3389/fendo.2023.1125299,https://pubmed.ncbi.nlm.nih.gov/37143720/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,29100035,The role of human chorionic gonadotropin in regulation of naïve and memory T cells activity in vitro.,2018,10.1016/j.intimp.2017.10.029,https://pubmed.ncbi.nlm.nih.gov/29100035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,31699218,Understanding tumor-infiltrating lymphocytes by single cell RNA sequencing.,2019,10.1016/bs.ai.2019.08.004,https://pubmed.ncbi.nlm.nih.gov/31699218/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,26085358,"Effects of Immunoregulatory Cytokines (IL-2, IL-7, and IL-15) on Expression of Gfi1 and U2afll4 Genes in T Cells at Different Stages of Differentiation.",2015,10.1007/s10517-015-2931-8,https://pubmed.ncbi.nlm.nih.gov/26085358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,31922947,Molecular and genomic characterization of a novel equine molluscum contagiosum-like virus.,2021,10.1099/jgv.0.001357,https://pubmed.ncbi.nlm.nih.gov/31922947/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,23246698,Human PSENEN and U2AF1L4 genes are concertedly regulated by a genuine bidirectional promoter.,2013,10.1016/j.gene.2012.11.058,https://pubmed.ncbi.nlm.nih.gov/23246698/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,30479382,Lineage tracking reveals dynamic relationships of T cells in colorectal cancer.,2018,10.1038/s41586-018-0694-x,https://pubmed.ncbi.nlm.nih.gov/30479382/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,24466755,[Dose-response effect of steroid hormones on the Gfi1 and U2afil4 gene expression in T lymphocytes at different stages of differentiation].,2013,10.7868/s0026898413040095,https://pubmed.ncbi.nlm.nih.gov/24466755/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGFLR1,ENSG00000126246,Unsafe,25193853,"Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy.",2014,10.18632/oncotarget.2374,https://pubmed.ncbi.nlm.nih.gov/25193853/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,42347245,Caco-2 Cell Co-Culture Alters the Molecular Size of Igl1 and Its Extracellular Fragments in &lt;i&gt;Entamoeba histolytica&lt;/i&gt;.,2026,10.3390/pathogens15060633,https://pubmed.ncbi.nlm.nih.gov/42347245/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,40011803,Transcriptomic analysis offers deep insights into the Increased Grain Length 1 (IGL1) regulation of grain length.,2025,10.1186/s12870-025-06279-2,https://pubmed.ncbi.nlm.nih.gov/40011803/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,41490289,H195Y mutation of IKZF3 identified in a mouse model of precursor B cell acute lymphoblastic leukemia impairs transcriptional repression activity and increases protein stability.,2026,10.1093/jleuko/qiag001,https://pubmed.ncbi.nlm.nih.gov/41490289/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,40443574,Two case reports of B-cell lymphopenia associated with &lt;i&gt;IGLL1&lt;/i&gt; variants identified through newborn screening in Ukraine.,2025,10.3389/fped.2025.1566867,https://pubmed.ncbi.nlm.nih.gov/40443574/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,42754520,Population-specific rare variants influence age at diagnosis in Korean inflammatory bowel disease.,2026,10.3904/kjim.2026.055,https://pubmed.ncbi.nlm.nih.gov/42754520/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,40910197,Prognostic Value and Immune Characterization of Genes Associated with Childhood Acute Leukemia applying Single-Cell RNA Sequencing.,2026,10.2174/0118715303420113250818064855,https://pubmed.ncbi.nlm.nih.gov/40910197/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,42131086,Circulating plasma protein biomarkers associated with risk of negative clinical outcomes in virally suppressed people with HIV receiving medications for opioid use disorder.,2026,10.3389/fmolb.2026.1728953,https://pubmed.ncbi.nlm.nih.gov/42131086/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,40640242,Integrative proteomics and metabolomics reveal important pathways and potential biomarkers in high-altitude pulmonary hypertension.,2025,10.1038/s41598-025-09477-y,https://pubmed.ncbi.nlm.nih.gov/40640242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,39846187,Ribosome profiling and single-cell RNA sequencing identify the unfolded protein response as a key regulator of pigeon lactation.,2025,10.24272/j.issn.2095-8137.2024.336,https://pubmed.ncbi.nlm.nih.gov/39846187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,37551468,[Expression of IGLL1 Gene and Its Clinical Significance in Pediatric T-ALL].,2023,10.19746/j.cnki.issn.1009-2137.2023.04.011,https://pubmed.ncbi.nlm.nih.gov/37551468/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,41459527,"Newborn screening for SCID and severe T- and B-cell lymphopenia in Ukraine: the first analysis of the results, 2022-2025.",2025,10.3389/fimmu.2025.1709657,https://pubmed.ncbi.nlm.nih.gov/41459527/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,40394466,Splenic comparative transcriptome analysis reveals the immunological mode of undomesticated Gayal (Bos frontalis) for adapting to harsh environments.,2025,10.1186/s12864-025-11718-3,https://pubmed.ncbi.nlm.nih.gov/40394466/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,37767202,Super Enhancer Regulatory Gene FYB1 Promotes the Progression of T Cell Acute Lymphoblastic Leukemia by Activating IGLL1.,2023,10.1155/2023/3804605,https://pubmed.ncbi.nlm.nih.gov/37767202/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,39594201,Proteomic Profiling of COVID-19 Patients Sera: Differential Expression with Varying Disease Stage and Potential Biomarkers.,2024,10.3390/diagnostics14222533,https://pubmed.ncbi.nlm.nih.gov/39594201/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,38388382,HERVK-mediated regulation of neighboring genes: implications for breast cancer prognosis.,2024,10.1186/s12977-024-00636-z,https://pubmed.ncbi.nlm.nih.gov/38388382/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,40174917,BCG induced innate immune response heterogeneity and susceptibility to pediatric tuberculosis.,2025,10.1093/jimmun/vkae062,https://pubmed.ncbi.nlm.nih.gov/40174917/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,37409118,A novel stemness classification in acute myeloid leukemia by the stemness index and the identification of cancer stem cell-related biomarkers.,2023,10.3389/fimmu.2023.1202825,https://pubmed.ncbi.nlm.nih.gov/37409118/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,39848208,Comprehensive analysis of gene expressions in ileal mucosa of chickens fed paddy rice and their IgA response to oral vaccination.,2025,10.1016/j.psj.2025.104823,https://pubmed.ncbi.nlm.nih.gov/39848208/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,34637826,CircRNA-IGLL1/miR-15a/RNF43 axis mediates ammonia-induced autophagy in broilers jejunum via Wnt/β-catenin pathway.,2022,10.1016/j.envpol.2021.118332,https://pubmed.ncbi.nlm.nih.gov/34637826/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,38752789,Comparative analysis of dynamic transcriptomes reveals specific COVID-19 features and pathogenesis of immunocompromised populations.,2024,10.1128/msystems.01385-23,https://pubmed.ncbi.nlm.nih.gov/38752789/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,39147326,Variants in IGLL1 cause a broad phenotype from agammaglobulinemia to transient hypogammaglobulinemia.,2024,10.1016/j.jaci.2024.08.002,https://pubmed.ncbi.nlm.nih.gov/39147326/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,36702834,Cross center single-cell RNA sequencing study of the immune microenvironment in rapid progressing multiple myeloma.,2023,10.1038/s41525-022-00340-x,https://pubmed.ncbi.nlm.nih.gov/36702834/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,36311706,Evolution of surrogate light chain in tetrapods and the relationship between lengths of CDR H3 and VpreB tails.,2022,10.3389/fimmu.2022.1001134,https://pubmed.ncbi.nlm.nih.gov/36311706/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,33907270,Tumor mutation burden (TMB)-associated signature constructed to predict survival of lung squamous cell carcinoma patients.,2021,10.1038/s41598-021-88694-7,https://pubmed.ncbi.nlm.nih.gov/33907270/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,36138806,Genetic Diversity and Selective Signature in Dabieshan Cattle Revealed by Whole-Genome Resequencing.,2022,10.3390/biology11091327,https://pubmed.ncbi.nlm.nih.gov/36138806/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,31291582,MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition.,2019,10.1016/j.celrep.2019.06.029,https://pubmed.ncbi.nlm.nih.gov/31291582/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IGLL1,ENSG00000128322,Unsafe,2128466,"The immunoglobulin lambda-like gene cluster (14.1, 16.1 and F lambda 1) contains gene(s) selectively expressed in pre-B cells and is the human counterpart of the mouse lambda 5 gene.",1990,10.1093/intimm/2.3.201,https://pubmed.ncbi.nlm.nih.gov/2128466/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,40761106,IKZF3 promotes gastric cancer progression via Hedgehog signaling activation and is targetable by SANT-1.,2025,10.3724/abbs.2025103,https://pubmed.ncbi.nlm.nih.gov/40761106/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,41820205,IKZF3 Promotes Gastric cancer Progression and Oxaliplatin Resistance via PI3K/AKT/mTOR Activation.,2026,10.1111/jgh.70331,https://pubmed.ncbi.nlm.nih.gov/41820205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,42118707,Mezigdomide reverses T-cell exhaustion through degradation of IKZF1/IKZF3 and reinvigoration of cytokine production pathways.,2026,10.1182/blood.2025030873,https://pubmed.ncbi.nlm.nih.gov/42118707/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,41490289,H195Y mutation of IKZF3 identified in a mouse model of precursor B cell acute lymphoblastic leukemia impairs transcriptional repression activity and increases protein stability.,2026,10.1093/jleuko/qiag001,https://pubmed.ncbi.nlm.nih.gov/41490289/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,41746515,Fatal Systemic Granulomatous Disease Associated with Vaccine-Derived Rubella Virus in AIOLOS-Associated Immunodeficiency.,2026,10.1007/s10875-026-01990-7,https://pubmed.ncbi.nlm.nih.gov/41746515/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,42624209,Proteomic Insights Into Human Induced Regulatory T Cells: The Role of LPXN and CD160 in Immune Suppression.,2026,10.1016/j.mcpro.2026.101644,https://pubmed.ncbi.nlm.nih.gov/42624209/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,41841545,Single-Cell and Mendelian Randomization Analyses Identify Key Genes Common to COVID-19 and Multiple Sclerosis.,2026,10.1177/08828245261426986,https://pubmed.ncbi.nlm.nih.gov/41841545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,42793205,"Associations of &lt;i&gt;ASIC2&lt;/i&gt;, &lt;i&gt;IKZF3&lt;/i&gt;, and &lt;i&gt;GSDMB&lt;/i&gt; Variants with Gestational Diabetes Mellitus and Their Interactions with Environmental Exposures Among Chinese Women.",2026,10.3390/biom16091373,https://pubmed.ncbi.nlm.nih.gov/42793205/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,41581221,Identifying expression and DNA methylation biomarkers for lung adenocarcinoma risk in East Asia.,2026,10.1093/jnci/djag021,https://pubmed.ncbi.nlm.nih.gov/41581221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,42685001,CXXC1-dependent IRF4 activity promotes myeloma cell fitness and sustains lenalidomide resistance.,2026,10.1182/blood.2026033534,https://pubmed.ncbi.nlm.nih.gov/42685001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,41782559,Non-HLA Risk Loci ERBB3/IKZF4 and ERBB2/IKZF3/GSDMB/ORMDL3 Interact to Influence Progression of Autoimmunity in Relatives of T1D Patients.,2026,10.1002/dmrr.70145,https://pubmed.ncbi.nlm.nih.gov/41782559/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,41639521,Single-cell Transcriptomic Profiling Reveals Diagnostic of T Cell-platelet Aggregates in Peripheral Blood for Coronary Vulnerable Plaques.,2026,10.1007/s12265-025-10723-x,https://pubmed.ncbi.nlm.nih.gov/41639521/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,42402721,Oncogenic DNMT3B as a therapeutic target for cervical cancer.,2026,10.1097/cm9.0000000000004130,https://pubmed.ncbi.nlm.nih.gov/42402721/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,41656816,[IKZF3/Aiolos and tumors].,2025,10.11817/j.issn.1672-7347.2025.240584,https://pubmed.ncbi.nlm.nih.gov/41656816/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,42499187,Identification of genetic variants associated with idiopathic inflammatory myopathies via cross-trait analysis with B cell lymphomas.,2026,10.1016/j.xhgg.2026.100658,https://pubmed.ncbi.nlm.nih.gov/42499187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,41248492,Catalytic Inhibition of p300 Preferentially Targets IRF4 Oncogenic Activity and Tumor Growth in Multiple Myeloma.,2026,10.1158/0008-5472.can-25-3440,https://pubmed.ncbi.nlm.nih.gov/41248492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,40123976,Dual CARM1-and IKZF3-targeting: A novel approach to multiple myeloma therapy synergy between CARM1 inhibition and IMiDs.,2025,10.1016/j.omton.2025.200952,https://pubmed.ncbi.nlm.nih.gov/40123976/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,42289349,Transcriptomic Analysis in the Liver of Two Rabbit Lines Divergently Selected for Intramuscular Fat Content.,2026,10.1002/age.70143,https://pubmed.ncbi.nlm.nih.gov/42289349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,41392082,"Aiolos restricts the generation of antigen-inexperienced, virtual memory CD8&lt;sup&gt;+&lt;/sup&gt; T cells in mice.",2025,10.1038/s41467-025-67540-8,https://pubmed.ncbi.nlm.nih.gov/41392082/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,42701819,Genetically Predicted Gene Expression and Circulating Metabolites Associated with Cervical High-Grade Squamous Intraepithelial Lesion: A Mendelian Randomization Study.,2026,10.2147/ijwh.s632165,https://pubmed.ncbi.nlm.nih.gov/42701819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,41651798,Targeting Ikaros and Aiolos: Next-Generation Cereblon E3 Ligase Modulators in MM.,2026,10.1111/ejh.70134,https://pubmed.ncbi.nlm.nih.gov/41651798/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,42720469,"Discovery of Highly Potent and Selective, Orally Bioavailable BTK-Targeting PROTACs Featuring Novel CRBN-Binding Warheads.",2026,10.1021/acs.jmedchem.6c01136,https://pubmed.ncbi.nlm.nih.gov/42720469/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,40817326,Targeting degradation of IKZF1 and IKZF3 through modulation of the E3 ligase substrates in the context of cellular therapies for multiple myeloma.,2025,10.1186/s40364-025-00825-8,https://pubmed.ncbi.nlm.nih.gov/40817326/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,42677819,"Discovery of BMS-986449: A Potent, Selective Degrader of the Transcription Factors IKZF2 (Helios) and IKZF4 (Eos) to Target Regulatory T Cells in Solid Tumors.",2026,10.1021/acs.jmedchem.6c01271,https://pubmed.ncbi.nlm.nih.gov/42677819/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,42378251,A single-cell atlas identifies oncogenic transcriptional programs and immune escape mechanisms in CTCL.,2026,10.1182/blood.2025032507,https://pubmed.ncbi.nlm.nih.gov/42378251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,41876537,A dihydrouracil CRBN ligand mitigates IMiD associated safety liabilities in heterobifunctional targeted protein degrader.,2026,10.1038/s41467-026-70663-1,https://pubmed.ncbi.nlm.nih.gov/41876537/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,41176706,Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells.,2025,10.1021/acschembio.5c00751,https://pubmed.ncbi.nlm.nih.gov/41176706/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,42169761,IKZF-associated inborn errors of immunity.,2025,10.70962/jhi.20250063,https://pubmed.ncbi.nlm.nih.gov/42169761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,39052108,IKZF3 amplification predicts worse prognosis especially in intestinal-type gastric cancer.,2024,10.1007/s00432-024-05868-2,https://pubmed.ncbi.nlm.nih.gov/39052108/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,38610997,Synergy between BRD9- and IKZF3-Targeting as a Therapeutic Strategy for Multiple Myeloma.,2024,10.3390/cancers16071319,https://pubmed.ncbi.nlm.nih.gov/38610997/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IKZF3,ENSG00000161405,Unsafe,17646674,Combinatorial effects of splice variants modulate function of Aiolos.,2007,10.1242/jcs.007344,https://pubmed.ncbi.nlm.nih.gov/17646674/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,42771994,Age-related changes of FCGR3A&lt;sup&gt;+&lt;/sup&gt; natural killer cells and their association with elderly atopic dermatitis.,2026,10.1016/j.ebiom.2026.106489,https://pubmed.ncbi.nlm.nih.gov/42771994/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,41605052,Integrated bioinformatics and machine learning deciphering IL12RB2 and FYN as key immune biomarkers in brucellosis.,2026,10.1016/j.intimp.2026.116268,https://pubmed.ncbi.nlm.nih.gov/41605052/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,42868031,Autoimmune hepatitis and primary biliary cholangitis are among a subset of autoimmune diseases defined by profound co-prevalence and genetic risk association with the IL12 pathway.,2026,10.1097/hep.0000000000001819,https://pubmed.ncbi.nlm.nih.gov/42868031/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,41340014,Revealing Causal Protein Biomarkers and Potential Therapeutic Targets for Histologic-Specific Lung Cancer.,2025,10.1111/jcmm.70866,https://pubmed.ncbi.nlm.nih.gov/41340014/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,41999721,Sex-specific autosomal susceptibility loci in systemic sclerosis: a genome-wide association study.,2026,10.1016/s2665-9913(25)00376-5,https://pubmed.ncbi.nlm.nih.gov/41999721/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,42513348,Patients with Crohn's Disease Achieving Ustekinumab-Induced Remission Are Characterized by Increased Baseline IL-23 Receptor Expression on Lamina Propria Th1 Cells.,2026,10.3390/jcm15145434,https://pubmed.ncbi.nlm.nih.gov/42513348/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,41716396,Comprehensive analysis of molecular immunological characteristics and potential biomarkers in brucellosis.,2026,10.3389/fimmu.2026.1614025,https://pubmed.ncbi.nlm.nih.gov/41716396/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,41576166,Resident CD49a&lt;sup&gt;+&lt;/sup&gt;CD103&lt;sup&gt;+&lt;/sup&gt;NKG2C&lt;sup&gt;+&lt;/sup&gt; NK cells restrict HIV infection in human lymphoid tissue explants.,2026,10.1126/sciadv.adz1565,https://pubmed.ncbi.nlm.nih.gov/41576166/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,41052344,A time-gated PKA-CREB signaling circuit licenses IL-12 responsiveness and Th1 fate in CD4&lt;sup&gt;+&lt;/sup&gt; T cells.,2025,10.1073/pnas.2517132122,https://pubmed.ncbi.nlm.nih.gov/41052344/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,42216402,Genetic mechanisms of primary biliary cholangitis and its association with immune cells using mendelian randomization and biological annotation.,2026,10.1097/md.0000000000049146,https://pubmed.ncbi.nlm.nih.gov/42216402/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,42756106,Real-world insights into genomic reprogramming during CAR-T cell manufacturing in India.,2026,10.3389/fimmu.2026.1912690,https://pubmed.ncbi.nlm.nih.gov/42756106/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,39242583,Gene expression changes in Brodmann's Area 46 differentiate epidermal growth factor and immune system interactions in schizophrenia and mood disorders.,2024,10.1038/s41537-024-00488-8,https://pubmed.ncbi.nlm.nih.gov/39242583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,40705171,PS77: a novel peptide with α-helical structure for targeted anti-inflammatory therapy in biomaterials design.,2025,10.1007/s12026-025-09663-0,https://pubmed.ncbi.nlm.nih.gov/40705171/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,40281224,Epigenetic markers of disease risk and psychotherapy response in anxiety disorders - a longitudinal analysis of the DNA methylome.,2025,10.1038/s41380-025-03038-5,https://pubmed.ncbi.nlm.nih.gov/40281224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,38561234,Chlamydia muridarum Associated Pulmonary and Urogenital Disease and Pathology in a Colony of Enzootically Infected Il12rb2 Deficient and Stat1 Knockout Mice.,2024,10.30802/aalas-cm-24-000002,https://pubmed.ncbi.nlm.nih.gov/38561234/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,41942635,Primary biliary cirrhosis and rheumatoid arthritis: a comprehensive study combining genetics and transcriptomics.,2026,10.1007/s00335-026-10224-5,https://pubmed.ncbi.nlm.nih.gov/41942635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,39814554,Roles of the CDCA gene family in breast carcinoma.,2025,10.1177/00368504241312305,https://pubmed.ncbi.nlm.nih.gov/39814554/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,40576689,Transcriptomic Analysis of Gene Expression in Immune Pathways in the Spleen of Takifugu rubripes After Infection with Scuticociliate Uronema marinum.,2025,10.1007/s11686-025-01076-1,https://pubmed.ncbi.nlm.nih.gov/40576689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,40332391,NK Cells Modulate Dendritic Cell (DC) Signaling Pathways and DC Recruitment in Chlamydial Infection.,2025,10.3390/ijms26083769,https://pubmed.ncbi.nlm.nih.gov/40332391/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,41961589,Immunological dysfunction associated with SARS-CoV-2 persistence in immunocompromised patients.,2026,10.1093/cei/uxag022,https://pubmed.ncbi.nlm.nih.gov/41961589/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,41284062,"Association of IL12RB2, RORC, and class II HLA polymorphisms with severe erythema multiforme of regorafenib in Japanese patients with colorectal cancer.",2025,10.1007/s00280-025-04841-1,https://pubmed.ncbi.nlm.nih.gov/41284062/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,40988251,Genetically proxied glucagon-like peptide-1 receptor agonist is associated with risk of tubulo-interstitial nephritis: A network Mendelian randomization study.,2025,10.1097/md.0000000000044742,https://pubmed.ncbi.nlm.nih.gov/40988251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,36694264,Predictive biomarkers for the responsiveness of recurrent glioblastomas to activated killer cell immunotherapy.,2023,10.1186/s13578-023-00961-4,https://pubmed.ncbi.nlm.nih.gov/36694264/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,38184395,Immunomodulatory properties of bacteriophage derived dsRNA of different size and their use as anticancer vaccine adjuvants.,2024,10.1016/j.vaccine.2023.12.071,https://pubmed.ncbi.nlm.nih.gov/38184395/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,40249873,RyR2-mediated calcium signaling regulates T-cell activation and Th1 differentiation.,2025,10.1093/jimmun/vkaf046,https://pubmed.ncbi.nlm.nih.gov/40249873/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL12RB2,ENSG00000081985,Unsafe,9120388,Selective expression of an interleukin-12 receptor component by human T helper 1 cells.,1997,10.1084/jem.185.5.825,https://pubmed.ncbi.nlm.nih.gov/9120388/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42418669,Mast cell-derived IL-13 as a driver of Crohn disease-associated intestinal fibrosis.,2026,10.1093/ibd/izag127,https://pubmed.ncbi.nlm.nih.gov/42418669/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42692359,Interleukin13 Ameliorates Hepatocellular Steatosis via IL13Rα1/JNK/FOSL2 Signaling Pathway.,2026,10.1016/j.jcmgh.2026.101879,https://pubmed.ncbi.nlm.nih.gov/42692359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42603621,Upadacitinib effectively suppresses IL13RA2 expression in primary human intestinal fibroblasts derived from Crohn's disease tissue.,2026,10.1016/j.bcp.2026.118367,https://pubmed.ncbi.nlm.nih.gov/42603621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42135900,"Type-2-Inflammatory-Diseases Share Comorbidities, Molecular Signatures, IL4/IL13 Genetics, and Response to IL4/IL13 Blockade.",2026,10.1111/all.70380,https://pubmed.ncbi.nlm.nih.gov/42135900/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42532515,Epigenetic Signature of the Metastable Epiallele VTRNA2-1: Adipose Dysfunction and Suboptimal Bariatric Outcomes.,2026,10.1002/oby.70268,https://pubmed.ncbi.nlm.nih.gov/42532515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42270589,Deficiency of G9a boosts muscle regeneration through IL13/Musclin-mediated crosstalk between macrophage and myofiber.,2026,10.1038/s41419-026-08944-2,https://pubmed.ncbi.nlm.nih.gov/42270589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42824269,"Analysis of distribution of IL13 and ADAM33 gene haplotypes in Russians, Khakass, Tuvans in relation to the risk of developing bronchial asthma.",2026,10.18699/vjgb-26-79,https://pubmed.ncbi.nlm.nih.gov/42824269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42350047,IL4Rα blockade inhibits proliferation of malignant lymphocytes and the immunosuppressive tumor microenvironment of mycosis fungoides.,2026,10.1136/jitc-2026-015022,https://pubmed.ncbi.nlm.nih.gov/42350047/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,41422061,Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors.,2025,10.1038/s41467-025-67539-1,https://pubmed.ncbi.nlm.nih.gov/41422061/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42237357,A combination therapy strategy: precision co-targeting of CCR7 and JAK1 with a smart hydrogel for inflammatory skin diseases.,2026,10.1186/s12951-026-04637-2,https://pubmed.ncbi.nlm.nih.gov/42237357/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,39883056,"Tumor cells upregulate neurotransmitter GABA in the choroid plexus through STAT6-Bestrophin1 signaling, promoting leptomeningeal dissemination.",2025,10.1093/neuonc/noaf027,https://pubmed.ncbi.nlm.nih.gov/39883056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,41981183,Lactate treatment improves brain biochemistry and cognitive function in transgenic Alzheimer's and wild-type mice.,2026,10.1038/s41598-026-48154-6,https://pubmed.ncbi.nlm.nih.gov/41981183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42497191,IL5 rs2069812 and IL13 rs1800925 Genetic variants as key determinants of clinically relevant asthma phenotypes.,2026,10.1371/journal.pone.0354597,https://pubmed.ncbi.nlm.nih.gov/42497191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,41814156,Dual and context-dependent role of the interleukin-33/soluble suppression of tumorigenicity 2 axis in obesity and adipose tissue inflammation.,2026,10.1186/s10020-026-01454-z,https://pubmed.ncbi.nlm.nih.gov/41814156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,41964693,Multifunctional 3D-Printed Titanium Alloy Composite-Coated Scaffold for Modulating the Immune Microenvironment and Promoting Osteogenesis.,2026,10.1021/acsami.6c02958,https://pubmed.ncbi.nlm.nih.gov/41964693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,41741455,Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis.,2026,10.1038/s41467-026-69587-7,https://pubmed.ncbi.nlm.nih.gov/41741455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42765450,GPR35-positive mast cells are enriched in primary sclerosing cholangitis and show an enhanced secretory phenotype.,2026,10.1080/00365521.2026.2731959,https://pubmed.ncbi.nlm.nih.gov/42765450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42874124,microRNA expression in macrophages regulates antibody-dependent effector function and B cell lymphoma therapy.,2026,10.1158/2767-9764.crc-25-0485,https://pubmed.ncbi.nlm.nih.gov/42874124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42061927,"Systemic modulation of toll-like receptors, cytokine polarization and inflammasome signaling in dogs with generalized demodicosis.",2026,10.1016/j.vetimm.2026.111127,https://pubmed.ncbi.nlm.nih.gov/42061927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42219389,"Immunoinflammatory Markers in Patients with Affective Disorders: Genetic Polymorphisms, Peripheral Cytokine Levels, and Expression of IL-1β, IL-13, TNF-β, and TGF-α in Peripheral Blood Mononuclear Cells.",2026,10.1134/s0006297926600304,https://pubmed.ncbi.nlm.nih.gov/42219389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,41776988,Characterization of Bronchiolitis and Vaccine-induced Enhanced Respiratory Disease in Syrian Hamsters Caused by Respiratory Syncytial Virus Infection.,2026,10.1093/infdis/jiag136,https://pubmed.ncbi.nlm.nih.gov/41776988/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42061467,Group 2 innate lymphoid cells: Where are we 15 years out?,2026,10.1016/j.jaci.2026.04.013,https://pubmed.ncbi.nlm.nih.gov/42061467/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42643717,Biological treatments for asthma and chronic obstructive pulmonary disease.,2026,10.1136/bmjmed-2025-002195,https://pubmed.ncbi.nlm.nih.gov/42643717/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,41159943,IL4/IL13 Inhibition via Dupilumab Reduces Malignant T-cell Proliferation and Promotes Antitumor Immunity in Sézary Syndrome.,2026,10.1158/2326-6066.cir-25-0677,https://pubmed.ncbi.nlm.nih.gov/41159943/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,37894718,Glioblastoma Immunotherapy: A Systematic Review of the Present Strategies and Prospects for Advancements.,2023,10.3390/ijms242015037,https://pubmed.ncbi.nlm.nih.gov/37894718/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42556471,Targeted Transcriptomic Profiling Identifies Biomarkers and Molecular Features Associated With Immunotherapy Response in Classic Hodgkin Lymphoma.,2026,10.1016/j.modpat.2026.101060,https://pubmed.ncbi.nlm.nih.gov/42556471/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,39662266,DPP4 promotes an immunoenhancing tumor microenvironment through exhausted CD8+ T cells with activating IL13-IL13RA2 axis in papillary thyroid cancer.,2025,10.1016/j.intimp.2024.113760,https://pubmed.ncbi.nlm.nih.gov/39662266/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42886313,Chlorella sorokiniana attenuates deoxynivalenol-exacerbated allergic dermatitis and type 2 immune responses in mice.,2026,10.1007/s12550-026-00686-6,https://pubmed.ncbi.nlm.nih.gov/42886313/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,41730399,Preclinical safety and anti-inflammatory activity of a standardized Justicia pectoralis Jacq. extract in experimental models of respiratory inflammation.,2026,10.1016/j.jep.2026.121411,https://pubmed.ncbi.nlm.nih.gov/41730399/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,41540212,Radiotherapy plus neoadjuvant and concomitant IL-13Rα2-directed immunotoxin therapy for diffuse intrinsic pontine glioma.,2026,10.1038/s42003-025-09155-9,https://pubmed.ncbi.nlm.nih.gov/41540212/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,42252125,Fate mapping reveals a prenatal-to-neonatal wave of ILC2s with a history of Cd3g expression.,2026,10.1093/jimmun/vkag124,https://pubmed.ncbi.nlm.nih.gov/42252125/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,41870278,Molecular and Immune Landscape of Recurrent and/or Distant Metastatic Squamous Cell Carcinoma of the Head and Neck: An EORTC/IMMUCAN Project.,2026,10.1158/1078-0432.ccr-25-3377,https://pubmed.ncbi.nlm.nih.gov/41870278/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,41003230,&lt;i&gt;Candida intermedia&lt;/i&gt; Supplementation Enhances Immune Response and Modulates the Gut Microbiome in SARS-CoV-2 Vaccinated Mice.,2025,10.3390/jof11090685,https://pubmed.ncbi.nlm.nih.gov/41003230/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,39399731,Anticancer and bioactivity effect of the AraA-IL13 fusion protein on the glioblastoma cell line.,2024,10.4103/rps.rps_92_23,https://pubmed.ncbi.nlm.nih.gov/39399731/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13,ENSG00000169194,Unsafe,41835115,Contribution of Immune Responses to &lt;i&gt;Aedes aegypti&lt;/i&gt; Saliva in Dengue Severity Among Patients with Atopic Dermatitis.,2026,10.2147/jir.s580550,https://pubmed.ncbi.nlm.nih.gov/41835115/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,42057694,Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors.,2026,10.1002/advs.202522391,https://pubmed.ncbi.nlm.nih.gov/42057694/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,42603621,Upadacitinib effectively suppresses IL13RA2 expression in primary human intestinal fibroblasts derived from Crohn's disease tissue.,2026,10.1016/j.bcp.2026.118367,https://pubmed.ncbi.nlm.nih.gov/42603621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,40855097,IL-13/IL-13Rα2 axis promotes proliferation of angiosarcoma cells.,2025,10.1038/s41598-025-15933-6,https://pubmed.ncbi.nlm.nih.gov/40855097/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,40663259,Loss of IL13RA2 promotes metastatic tumor growth in triple-negative breast cancer via increased AKT and NF-κB signaling.,2025,10.1007/s10585-025-10362-1,https://pubmed.ncbi.nlm.nih.gov/40663259/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,41624510,Development and evaluation of IL13RA2 targeted drug delivery system based on glioblastoma homing peptide A2b11.,2026,10.1016/j.mtbio.2026.102823,https://pubmed.ncbi.nlm.nih.gov/41624510/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,41151835,Bi-specific T cell-engaging antibody triggers protective immune memory and glioma microenvironment remodeling in immune-competent preclinical models.,2025,10.1136/jitc-2025-011714,https://pubmed.ncbi.nlm.nih.gov/41151835/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,41563717,Combining Cytokine-Related Biomarkers to Better Define Tumor Necrosis Factor-α Antagonist Response in Inflammatory Bowel Disease: An Observational Cohort Study.,2026,10.14309/ctg.0000000000000960,https://pubmed.ncbi.nlm.nih.gov/41563717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,40176156,IL13RA2-integrated genetically engineered mouse model allows for CAR T cells targeting pediatric high-grade gliomas.,2025,10.1186/s40478-025-01991-4,https://pubmed.ncbi.nlm.nih.gov/40176156/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,41182523,Unveiling the expression and mechanistic role of SYCP2 in cervical lesions.,2025,10.1007/s12672-025-03894-1,https://pubmed.ncbi.nlm.nih.gov/41182523/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,41671911,LEF1 and IL13RA2 in testicular sex cord-stromal tumors: LEF1 as a potential diagnostic marker for Sertoli cell tumors.,2026,10.1016/j.anndiagpath.2026.152622,https://pubmed.ncbi.nlm.nih.gov/41671911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,42801784,"Peripheral Blood Immunogenomic Cytokine-receptor Signature (CXCR1, IL11RA, IL13RA2, CD19) Predicts HBV-related Cirrhosis: Public PBMC Transcriptome Mining and Nomogram Development.",2026,10.18502/ijaai.v25i5.22263,https://pubmed.ncbi.nlm.nih.gov/42801784/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,39472405,Unveiling the significance of cancer-testis antigens and their implications for immunotherapy in glioma.,2024,10.1007/s12672-024-01449-4,https://pubmed.ncbi.nlm.nih.gov/39472405/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,42546699,EGFR inhibition promotes functional engraftment and graft survival via donor-derived CHI3L1 in fetal RPE suspension transplantation.,2026,10.1016/j.xcrm.2026.102963,https://pubmed.ncbi.nlm.nih.gov/42546699/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,41880523,Dissecting glioblastoma risk signatures in the tumor immune microenvironment based on multi-dimensional transcriptomics.,2026,10.1093/gigascience/giag035,https://pubmed.ncbi.nlm.nih.gov/41880523/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,42233283,Spatial dissection of antibody-drug conjugate/radiopharmaceutical therapy targets defines heterogeneous expression landscapes and therapeutic implications in rhabdoid tumors.,2026,10.1093/neuonc/noag133,https://pubmed.ncbi.nlm.nih.gov/42233283/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,39220137,IL13RA2 promotes progression of infantile haemangioma by activating glycolysis and the Wnt/β-catenin signaling pathway.,2024,10.32604/or.2024.048315,https://pubmed.ncbi.nlm.nih.gov/39220137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,42461936,"Screening of core targets for Di(2-ethylhexyl) Phthalate-related gastric cancer based on machine learning, molecular docking, and SHAP analysis.",2026,10.1371/journal.pcbi.1014514,https://pubmed.ncbi.nlm.nih.gov/42461936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,40964747,Screening and Validation of Genes Associated With Lysosomal-Dependent Cell Death in Colorectal Cancer.,2025,10.1002/mc.70024,https://pubmed.ncbi.nlm.nih.gov/40964747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,41370379,Decoding the CHI3L1/IL-13Rα2 signaling nexus in MASH-fibrosis pathogenesis.,2025,10.1126/sciadv.adz3223,https://pubmed.ncbi.nlm.nih.gov/41370379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,40797114,Novel IL13RA2-targeted immunocytokines exhibit superior antitumor activities.,2025,10.1038/s41401-025-01611-w,https://pubmed.ncbi.nlm.nih.gov/40797114/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,42410253,OncoMimic peptide-based immunotherapy EO2401 induces shared T cell clusters in patients with adrenal cancer.,2026,10.1038/s43856-026-01755-8,https://pubmed.ncbi.nlm.nih.gov/42410253/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,40138603,Expanding the Therapeutic Reach of Chimeric Antigen Receptor T-Cells and Bispecific T-Cell Engagers Across Solid Tumors.,2025,10.1200/po-24-00753,https://pubmed.ncbi.nlm.nih.gov/40138603/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,38201655,Expression of Interleukin-13 Receptor Alpha 2 in Brainstem Gliomas.,2024,10.3390/cancers16010228,https://pubmed.ncbi.nlm.nih.gov/38201655/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,39662266,DPP4 promotes an immunoenhancing tumor microenvironment through exhausted CD8+ T cells with activating IL13-IL13RA2 axis in papillary thyroid cancer.,2025,10.1016/j.intimp.2024.113760,https://pubmed.ncbi.nlm.nih.gov/39662266/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,40770411,CREB5 promotes tumorigenicity and upregulates druggable cell surface modalities in basal-like breast cancer.,2025,10.1038/s41698-025-01051-z,https://pubmed.ncbi.nlm.nih.gov/40770411/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,40518621,Utilization of universal-targeting mSA2 CAR-T cells for the treatment of glioblastoma.,2025,10.1080/2162402x.2025.2518631,https://pubmed.ncbi.nlm.nih.gov/40518621/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,41511314,Comprehensive Characterization of the Immune Microenvironment of Colorectal and Gastric Signet Ring Cell Cancer.,2025,10.3390/cells15010030,https://pubmed.ncbi.nlm.nih.gov/41511314/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL13RA2,ENSG00000123496,Unsafe,40349527,Dupilumab-associated lymphoproliferative disorders: a comprehensive review on clinicohistopathologic features and underlying mechanisms.,2025,10.1016/j.coi.2025.102563,https://pubmed.ncbi.nlm.nih.gov/40349527/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,42666328,Type 17 T-cell subset divergence in hidradenitis suppurativa versus psoriasis: a comparative single-cell transcriptomic analysis.,2026,10.3389/fimmu.2026.1835460,https://pubmed.ncbi.nlm.nih.gov/42666328/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,42471772,Identification of Prognostic Genes Relevant With the Nuclear Factors of Activated T Cells Based on Transcriptomics in Oral Squamous Cell Carcinoma.,2026,10.1002/cre2.70408,https://pubmed.ncbi.nlm.nih.gov/42471772/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,41939913,Rapamycin treatment ameliorates HLA-B27-mediated gut inflammation and alters the microbiome in experimental spondyloarthritis.,2026,10.3389/fimmu.2026.1755132,https://pubmed.ncbi.nlm.nih.gov/41939913/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,41766817,Transcriptomic profiling reveals distinct molecular signatures among lesion types in hidradenitis suppurativa.,2025,10.3389/fimmu.2025.1715474,https://pubmed.ncbi.nlm.nih.gov/41766817/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,42374093,Diabetes exacerbates experimental peri-implantitis in mice with elevated IL-17A-associated inflammation and IL-17F upregulation.,2026,10.1038/s41598-026-58925-w,https://pubmed.ncbi.nlm.nih.gov/42374093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,41507783,IL17F&lt;sup&gt;+&lt;/sup&gt; naïve and IFNγ&lt;sup&gt;+&lt;/sup&gt; memory CD8 T cells drive hepatic dysfunction in the cecal ligation and puncture model of sepsis.,2026,10.1186/s10020-025-01411-2,https://pubmed.ncbi.nlm.nih.gov/41507783/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,42848102,H2A.J is an epigenetic driver of IL-17-associated inflammation in T&lt;sub&gt;H&lt;/sub&gt;17 cells and keratinocytes.,2026,10.1186/s43556-026-00611-4,https://pubmed.ncbi.nlm.nih.gov/42848102/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,42370858,Investigating the role of single-nucleotide polymorphisms of PTGS2 and IL17 gene with allergic asthma susceptibility in the Indian population.,2026,10.1080/02770903.2026.2696577,https://pubmed.ncbi.nlm.nih.gov/42370858/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,41580158,Bimekizumab long-term response in psoriasis: Mechanistic insights into efficacy level and durability.,2026,10.1016/j.jaci.2025.12.1013,https://pubmed.ncbi.nlm.nih.gov/41580158/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,41918778,Indole-3-Lactic Acid Attenuates IMQ-Induced Psoriasiform Dermatitis in Mice via AhR-Dependent Suppression of IL-17A.,2026,10.2147/ptt.s585731,https://pubmed.ncbi.nlm.nih.gov/41918778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,40531174,RORγt Inhibition Reduces Protumor Inflammation and Decreases Tumor Growth in Experimental Models of Lung Cancer.,2025,10.1158/2326-6066.cir-24-1128,https://pubmed.ncbi.nlm.nih.gov/40531174/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,40163531,Transcriptional and cytokine signatures of Mycobacterium abscessus complex pulmonary disease during disease progression and treatment.,2025,10.1371/journal.pntd.0012943,https://pubmed.ncbi.nlm.nih.gov/40163531/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,42105815,Candidalysin promotes fungal-specific Th17 CD4 T cell differentiation and protective systemic immunogenicity.,2026,10.1016/j.mucimm.2026.100348,https://pubmed.ncbi.nlm.nih.gov/42105815/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,42908915,"High-dose capsaicin exposure is associated with more severe inflammation, intestinal dysregulation, and IL-17 elevation in experimental autoimmune uveitis.",2026,10.3389/fmicb.2026.1952362,https://pubmed.ncbi.nlm.nih.gov/42908915/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,39055908,NOTCH1 is positively correlated with IL17F in Helicobacter pylori infection and a biomarker for mucosal injury.,2024,10.1016/j.isci.2024.110323,https://pubmed.ncbi.nlm.nih.gov/39055908/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,42147334,Unraveling novel therapeutic targets for diffuse large B-cell lymphoma: a plasma multi-omics study.,2026,10.3389/fphar.2026.1833739,https://pubmed.ncbi.nlm.nih.gov/42147334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,41974980,"Association of serum TNF-α, IL-17 A, and IL-17 F levels with disease activity in Yemeni patients with rheumatoid arthritis.",2026,10.1038/s41598-026-48852-1,https://pubmed.ncbi.nlm.nih.gov/41974980/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,41490611,IL17-related gene polymorphisms associated with orbital inflammatory diseases and their clinical features.,2026,10.1016/j.exer.2025.110838,https://pubmed.ncbi.nlm.nih.gov/41490611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,41433124,Single-cell characterization of the gastrointestinal HIV reservoir reveals heterogeneous cellular phenotypes.,2026,10.1172/jci196536,https://pubmed.ncbi.nlm.nih.gov/41433124/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,40985896,Th17 cells with regulatory phenotype are the main IL-17F and IL-26 producers in palmoplantar pustulosis.,2025,10.1172/jci.insight.193038,https://pubmed.ncbi.nlm.nih.gov/40985896/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,42360819,Peripheral Th17 Immune Signature Associates with Excellent Response to Anti-PD-1/Anti-PD-L1 Therapy across Solid Tumors.,2026,10.1158/2326-6066.cir-25-1611,https://pubmed.ncbi.nlm.nih.gov/42360819/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,42368388,Bimekizumab rescue therapy in a patient with relapsing polychondritis-associated aortitis.,2025,10.1016/j.ero.2025.05.005,https://pubmed.ncbi.nlm.nih.gov/42368388/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,41572349,Itaconate and its derivatives ameliorate autoimmunity by suppressing Th17 cells via regulating mitophagy.,2026,10.1186/s12964-025-02621-1,https://pubmed.ncbi.nlm.nih.gov/41572349/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,40847911,Efficacy and tolerability of bimekizumab within patients with moderate-to-severe plaque psoriasis: learnings from real world evidence.,2026,10.1080/14740338.2025.2553058,https://pubmed.ncbi.nlm.nih.gov/40847911/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,40544015,"Mast cells express IL17A, IL17F and RORC in lesional psoriatic skin, are activated before therapy and persist in high numbers in a resting state with IL-17A positivity after treatment.",2025,10.1016/j.jdermsci.2025.05.006,https://pubmed.ncbi.nlm.nih.gov/40544015/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,42274553,Network Toxicology and Transcriptomic Analyses Reveal Ferroptosis-Related Neurotoxicity of Rotenone as an Environmental Hazardous Compound.,2026,10.3390/cells15110959,https://pubmed.ncbi.nlm.nih.gov/42274553/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL17F,ENSG00000112116,Unsafe,11591768,"Identification of a novel cytokine, ML-1, and its expression in subjects with asthma.",2001,10.4049/jimmunol.167.8.4430,https://pubmed.ncbi.nlm.nih.gov/11591768/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42724844,Microplastics and nanoplastics-related genes signature predicts prognosis in pancreatic ductal adenocarcinoma and functional validation of interleukin 1 alpha.,2026,10.21037/tcr-2026-1405,https://pubmed.ncbi.nlm.nih.gov/42724844/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42635977,THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A.,2026,10.1002/advs.77422,https://pubmed.ncbi.nlm.nih.gov/42635977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42338433,Activation of MyD88/IRAK1 axis and downstream proinflammatory signaling in healthy adult and neonatal African American skin.,2026,10.1016/j.xjidi.2026.100488,https://pubmed.ncbi.nlm.nih.gov/42338433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42142275,Integrative bioinformatics and experimental validation identify IL1A as a novel therapeutic target for diabetic wound healing.,2026,10.1007/s10238-026-02121-7,https://pubmed.ncbi.nlm.nih.gov/42142275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42534541,Targeting senescence-associated secretory phenotype macrophage: apigenin inhibits DOT1L-dependent H3K79me2 at &lt;i&gt;IL1A&lt;/i&gt; to fight SASP in senescent macrophages.,2026,10.3389/fmolb.2026.1801780,https://pubmed.ncbi.nlm.nih.gov/42534541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42187624,Interleukin-1 Polymorphisms in Caucasian Adults with Down Syndrome and Advanced Periodontitis: A Cross-Sectional Study.,2026,10.3390/dj14050246,https://pubmed.ncbi.nlm.nih.gov/42187624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,41575618,The prognostic value of miR-323b-5p in non-small cell lung cancer and its mechanism of targeting IL1A in regulating the proliferation and cell cycle of non-small cell lung cancer cells.,2026,10.1007/s12672-026-04409-2,https://pubmed.ncbi.nlm.nih.gov/41575618/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42291621,"Combining Machine Learning, Single-Cell Sequencing Data, and Mendelian Randomization Studies to Explore the Correlation Between Ischemic Stroke and Inflammatory Pathway Genes.",2026,10.1155/ijog/7253270,https://pubmed.ncbi.nlm.nih.gov/42291621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,41728092,IL1A enhances TNF-induced retinal ganglion cell death.,2026,10.3389/fnagi.2026.1754881,https://pubmed.ncbi.nlm.nih.gov/41728092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42730928,Spatially fractionated mini-GRID radiotherapy differentially modulates radiation-induced senescence in murine glioma and normal cells.,2026,10.18632/aging.206410,https://pubmed.ncbi.nlm.nih.gov/42730928/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,40883024,"Identification of &lt;i&gt;CXCL8, IL1A&lt;/i&gt;, and &lt;i&gt;IL1B&lt;/i&gt; as Hub Genes of Therapeutic Resistance in Glioblastoma Multiforme &lt;i&gt;via&lt;/i&gt; Bioinformatics Analysis.",2025,10.21873/cgp.20537,https://pubmed.ncbi.nlm.nih.gov/40883024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42760759,Identification of Inflammatory Cell Death-Related Prognostic Signature and Its Regulatory Mechanism in Lung Adenocarcinoma.,2026,10.1002/cam4.72255,https://pubmed.ncbi.nlm.nih.gov/42760759/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42516405,Single-cell RNA sequencing reveals microglial proliferative bias and neuroinflammatory communication reprogramming following traumatic brain injury.,2026,10.3389/fneur.2026.1789863,https://pubmed.ncbi.nlm.nih.gov/42516405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42731998,A pro-inflammatory metastasis-associated macrophage subset induces tumor-promoting mesothelial cell conversion in ovarian cancer via IL-1α secretion.,2026,10.1038/s41419-026-09280-1,https://pubmed.ncbi.nlm.nih.gov/42731998/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42085637,Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target.,2026,10.1002/advs.75523,https://pubmed.ncbi.nlm.nih.gov/42085637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42893853,Effects of intravaginal infusion of the osteopontin peptide possessing integrin-binding motifs on an inflammation-like response in the endometrium of dairy cows.,2026,10.1262/jrd.2026-058,https://pubmed.ncbi.nlm.nih.gov/42893853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42683095,Adverse Effects of Airborne Heavy Metals on Human Skin Cells: Insights From Sebum Analysis of Indoor and Outdoor Workers.,2026,10.1155/jt/7925949,https://pubmed.ncbi.nlm.nih.gov/42683095/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42146764,High Mobility Group Protein B1 Promotes Interferon Regulatory Factor 1 SUMOylation to Prime Trained Immunity of Circulating Monocytes and Aggravate the Progressive Synovial Inflammation in Knee Osteoarthritis.,2026,10.34133/research.1243,https://pubmed.ncbi.nlm.nih.gov/42146764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,40760541,Roles of JUN and MMP1 in lung cancer brain metastases.,2025,10.1097/md.0000000000042254,https://pubmed.ncbi.nlm.nih.gov/40760541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42384984,"Influence of inflammatory and reninangiotensin system gene polymorphisms ACE2 rs2285666, IL1A rs1800587, and TNF rs1800629 on COVID-19 severity and the persistence of symptoms in the post-COVID-19 phase: a cross-sectional study.",2026,10.31744/einstein_journal/2026ao1503,https://pubmed.ncbi.nlm.nih.gov/42384984/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42647624,Carbon ion irradiation at a clinically used dose rewires super-enhancers to drive necroptosis and systemic immunity.,2026,10.1126/sciadv.aec7590,https://pubmed.ncbi.nlm.nih.gov/42647624/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,41556358,PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma.,2026,10.1002/advs.202515207,https://pubmed.ncbi.nlm.nih.gov/41556358/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,40612864,IL1A: a novel prognostic biomarker and potential therapeutic target for renal clear cell carcinoma.,2025,10.32604/or.2025.061978,https://pubmed.ncbi.nlm.nih.gov/40612864/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42349522,Genome-wide transcriptome profiling in crossbred pigs after challenge with Classical Swine Fever Virus.,2026,10.1016/j.micpath.2026.108659,https://pubmed.ncbi.nlm.nih.gov/42349522/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42316430,Transcriptomic Profiling of Cutaneous Melanoma Metastases Treated With Microwave Ablation-Pilot Study.,2026,10.1111/cts.70638,https://pubmed.ncbi.nlm.nih.gov/42316430/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,41198835,Efferocytosis-related signatures identified via Single-cell analysis and machine learning predict TNBC outcomes and immunotherapy response.,2025,10.1038/s41598-025-22816-3,https://pubmed.ncbi.nlm.nih.gov/41198835/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42033610,Interleukin-1α (IL-1α) in pancreatic ductal adenocarcinoma: implications for immunotherapy and molecular biomarkers.,2026,10.1007/s12094-026-04325-5,https://pubmed.ncbi.nlm.nih.gov/42033610/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,41824427,Elucidating the mechanistic association of xylene inducing non-small cell lung cancer through network toxicology and molecular docking analysis.,2026,10.1371/journal.pone.0341548,https://pubmed.ncbi.nlm.nih.gov/41824427/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,41578551,Propionate metabolism-related molecular subtypes and prognostic signature in lung adenocarcinoma.,2026,10.1097/md.0000000000047270,https://pubmed.ncbi.nlm.nih.gov/41578551/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42108216,Meta-Analysis of Transcriptomic Datasets Reveals Key Immune Gene Profiles and Signaling Pathways in Bos taurus.,2026,10.1002/age.70117,https://pubmed.ncbi.nlm.nih.gov/42108216/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42328458,Targeting IL-1α Sensitizes HNSCC to PDT by Reversing Hypoxia and NF-κB-Driven Oxidative Stress Resistance.,2026,10.7150/ijbs.131696,https://pubmed.ncbi.nlm.nih.gov/42328458/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,41784867,Time-resolved urinary proteomics reveals heme-associated oxidative stress responses in neonatal hypoxic-ischaemic encephalopathy.,2026,10.1186/s40348-026-00222-7,https://pubmed.ncbi.nlm.nih.gov/41784867/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,42156493,Oncolytic vaccinia virus JX-594 shows subtype-specific activity and candidate biomarkers in gastric cancer cell lines.,2026,10.1038/s41598-026-51477-z,https://pubmed.ncbi.nlm.nih.gov/42156493/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,40561608,"Integrating network toxicology, transcriptomics, and metabolomics uncovers the hepatotoxic mechanisms of okadaic acid in LO2 cells.",2025,10.1016/j.ecoenv.2025.118576,https://pubmed.ncbi.nlm.nih.gov/40561608/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL1A,ENSG00000115008,Unsafe,40989165,"A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer.",2025,10.1515/med-2025-1247,https://pubmed.ncbi.nlm.nih.gov/40989165/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,42433376,IL21 is predominantly produced by a CXCL13 associated CD4&lt;sup&gt;+&lt;/sup&gt; T cell subset and shapes the immune microenvironment in colorectal cancer.,2026,10.3389/fimmu.2026.1865519,https://pubmed.ncbi.nlm.nih.gov/42433376/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,42589382,PVR Mediates Resistance to IL21.CD276.CAR-T Therapy in Esophageal Squamous Cell Carcinoma.,2026,10.3390/ijms27156725,https://pubmed.ncbi.nlm.nih.gov/42589382/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,42756494,"PBMC-derive eNK cells was armed and promoted CAR-like response against tumors through armed with 16Fc21, a novel bispecific fusion protein for NK cells.",2026,10.3389/fimmu.2026.1875554,https://pubmed.ncbi.nlm.nih.gov/42756494/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,41686183,The Presence of CD11c+ B Cells with Potent Effector Memory Phenotype in Lung Adenocarcinoma Correlates with Overall Patient Survival.,2026,10.1158/2326-6066.cir-25-0635,https://pubmed.ncbi.nlm.nih.gov/41686183/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,40569285,GPC2-Targeted CAR T Cells Engineered with NFAT-Inducible Membrane-Tethered IL15/IL21 Exhibit Enhanced Activity against Neuroblastoma.,2025,10.1158/2326-6066.cir-24-0975,https://pubmed.ncbi.nlm.nih.gov/40569285/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,41710873,"Aberrant STAT3 activation and overproduction of IL-21 in systemic lupus erythematosus: role of miR-155 and miR-21 in target genes &lt;i&gt;SOCS1, PTEN&lt;/i&gt; and &lt;i&gt;PIAS3&lt;/i&gt;.",2026,10.3389/fimmu.2026.1664409,https://pubmed.ncbi.nlm.nih.gov/41710873/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,41608503,IL21-STAT3 controls the pentose phosphate pathway to support metabolic reprogramming and tumor progression in chronic lymphocytic leukemia.,2026,10.1002/hem3.70292,https://pubmed.ncbi.nlm.nih.gov/41608503/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,42536711,Dynamic expression of IL-21 in effector CD8 T cells helps control chronic infections.,2026,10.1126/sciimmunol.aec5171,https://pubmed.ncbi.nlm.nih.gov/42536711/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,42666328,Type 17 T-cell subset divergence in hidradenitis suppurativa versus psoriasis: a comparative single-cell transcriptomic analysis.,2026,10.3389/fimmu.2026.1835460,https://pubmed.ncbi.nlm.nih.gov/42666328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,42536056,Immune Hallmarks of Recurrent Immune Checkpoint Inhibitor-Mediated Inflammatory Arthritis.,2026,10.1158/2326-6066.cir-25-1639,https://pubmed.ncbi.nlm.nih.gov/42536056/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,41035651,Th17-associated cytokine gene hypomethylation reflects epigenetic dysregulation in graves' disease.,2025,10.3389/fimmu.2025.1635883,https://pubmed.ncbi.nlm.nih.gov/41035651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,41939878,Dynamic progression of ectopic lymphoid structure formation in lacrimal glands of a Sjögren's disease murine model.,2026,10.3389/fimmu.2026.1797691,https://pubmed.ncbi.nlm.nih.gov/41939878/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,42718978,p38γ and p38δ support CD4&lt;sup&gt;+&lt;/sup&gt; T cell responses and T cell-dependent humoral immunity.,2026,10.3389/fimmu.2026.1927358,https://pubmed.ncbi.nlm.nih.gov/42718978/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,42272857,Dietary chicory rhamnogalacturonan-I modulates gut microbiota and immune responses in healthy adults.,2026,10.20517/mrr.2026.04,https://pubmed.ncbi.nlm.nih.gov/42272857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,42409796,Tumor-draining lymph nodes shape the tumor microenvironment through enrichment of tumor-reactive effector-exhausted CD8&lt;sup&gt;+&lt;/sup&gt; T cells.,2026,10.1038/s41392-026-02858-3,https://pubmed.ncbi.nlm.nih.gov/42409796/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,42189985,Epstein-Barr virus (EBV) infection causes human germinal center B cell-derived lymphomas in the absence of EBNA2 expression.,2026,10.1073/pnas.2525164123,https://pubmed.ncbi.nlm.nih.gov/42189985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,41828599,Gene Expression Profiles in the Optic Nerve of Mice with Systemic Acanthamoebiasis.,2026,10.3390/ijms27052382,https://pubmed.ncbi.nlm.nih.gov/41828599/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,42367764,Antigen-scaffolds loaded with hyper-stable neoleukin-2/15 expand antigen-specific T cells with a favorable phenotype for adoptive cell therapy.,2026,10.3389/fimmu.2026.1804678,https://pubmed.ncbi.nlm.nih.gov/42367764/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,39746095,Polymyositis in Kooiker dogs is associated with a 39 kb deletion upstream of the canine IL21/IL2 locus.,2025,10.1371/journal.pgen.1011538,https://pubmed.ncbi.nlm.nih.gov/39746095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,42256627,AhR agonist Ficz modulates T follicular helper cells and ameliorates skin fibrosis in a bleomycin-induced SSc mouse model.,2026,10.1136/jsrd-2026-000006,https://pubmed.ncbi.nlm.nih.gov/42256627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,40062380,Specific Genetic Mutations Impact Chemotherapy Resistance and Therapeutic Efficacy of Oncolytic Viruses in Ovarian Cancer.,2025,10.1158/1535-7163.mct-24-0906,https://pubmed.ncbi.nlm.nih.gov/40062380/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,38289325,IL15 and IL21: Better When Membrane-Tethered Together on Antitumor T Cells.,2024,10.1158/1078-0432.ccr-23-3466,https://pubmed.ncbi.nlm.nih.gov/38289325/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,41205611,Highly functional and prolonged germinal center T follicular helper cell responses are associated with enhanced neutralizing antibody development.,2025,10.1016/j.immuni.2025.10.008,https://pubmed.ncbi.nlm.nih.gov/41205611/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,41576135,Transient disruption of T cell help impairs germinal center dynamics and memory responses.,2026,10.1126/sciimmunol.adu9280,https://pubmed.ncbi.nlm.nih.gov/41576135/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,42148884,Incidence of B-cell Malignancies in Patients with Lung Cancer Receiving PD-1 Blockade Therapy.,2026,10.1158/1078-0432.ccr-25-3406,https://pubmed.ncbi.nlm.nih.gov/42148884/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,42360819,Peripheral Th17 Immune Signature Associates with Excellent Response to Anti-PD-1/Anti-PD-L1 Therapy across Solid Tumors.,2026,10.1158/2326-6066.cir-25-1611,https://pubmed.ncbi.nlm.nih.gov/42360819/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,40036068,The saponin monophosphoryl lipid A nanoparticle adjuvant induces dose-dependent HIV vaccine responses in nonhuman primates.,2025,10.1172/jci185292,https://pubmed.ncbi.nlm.nih.gov/40036068/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,37910044,Cooperative Armoring of CAR and TCR T Cells by T Cell-Restricted IL15 and IL21 Universally Enhances Solid Tumor Efficacy.,2024,10.1158/1078-0432.ccr-23-1872,https://pubmed.ncbi.nlm.nih.gov/37910044/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,39093981,Epigenetic agents plus anti-PD-1 reprogram the tumor microenvironment and restore antitumor efficacy in Hodgkin lymphoma.,2024,10.1182/blood.2024024487,https://pubmed.ncbi.nlm.nih.gov/39093981/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,41566359,Commensal microbe-derived butyrate enhances T follicular helper cell function to boost mucosal vaccine efficacy.,2026,10.1186/s40168-025-02284-7,https://pubmed.ncbi.nlm.nih.gov/41566359/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL21,ENSG00000138684,Unsafe,11081504,Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function.,2000,10.1038/35040504,https://pubmed.ncbi.nlm.nih.gov/11081504/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,42259525,Nonapeptide molecular evolution during the adaptive radiation of Tanganyika cichlids.,2026,10.1111/jne.70203,https://pubmed.ncbi.nlm.nih.gov/42259525/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,40877425,Inactivation mechanisms of Na&lt;sup&gt;+&lt;/sup&gt;/ HCO 3 - cotransporter NBCe1 by phosphorylation.,2025,10.1038/s42003-025-08713-5,https://pubmed.ncbi.nlm.nih.gov/40877425/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,40572022,Mouse genome engineering uncovers 18 genes dispensable for male reproduction.,2026,10.1111/andr.70088,https://pubmed.ncbi.nlm.nih.gov/40572022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,40981401,IGH::IL3-Rearranged B-Cell Precursor Acute Lymphoblastic Leukemia With Hypereosinophilia in a Child With a Novel PAX5 Germline Variant.,2025,10.1002/gcc.70080,https://pubmed.ncbi.nlm.nih.gov/40981401/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,41326769,Machine learning-driven glycolytic subtyping and exosome-based PKM splicing modulation overcome drug resistance in hyper-glycolytic myeloid leukemia.,2025,10.1038/s41746-025-02185-x,https://pubmed.ncbi.nlm.nih.gov/41326769/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,41662271,An upstream secondary DNA motif within the IL3 insulator CTCF binding site is required for enhancer-blocking insulator activity.,2026,10.1371/journal.pone.0340247,https://pubmed.ncbi.nlm.nih.gov/41662271/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,40453143,A novel 3-way translocation involving &lt;i&gt;ETV6&lt;/i&gt;::&lt;i&gt;IL3&lt;/i&gt; drives AML with eosinophilia.,2025,10.1016/j.bneo.2025.100079,https://pubmed.ncbi.nlm.nih.gov/40453143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,42906626,Serodiagnosis of Human Strongyloidiasis in Brazil and Peru Using Strongyloides venezuelensis Antigens: A Comparative Study in Endemic Settings.,2026,10.1111/pim.70109,https://pubmed.ncbi.nlm.nih.gov/42906626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,41829819,Genomic Selection for Lodging-Related Traits in Double-Cropping Rice.,2026,10.3390/plants15050785,https://pubmed.ncbi.nlm.nih.gov/41829819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,39923209,Novel ETV6::RAPGEF6 fusion gene in chronic eosinophilic leukemia: compiling evidence on the role of IL3 overexpression in tumorigenesis.,2025,10.1007/s00277-025-06217-0,https://pubmed.ncbi.nlm.nih.gov/39923209/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,39245720,Human cell surface-AAV interactomes identify LRP6 as blood-brain barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder.,2024,10.1038/s41467-024-52149-0,https://pubmed.ncbi.nlm.nih.gov/39245720/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,38739030,IL3-Driven T Cell-Basophil Crosstalk Enhances Antitumor Immunity.,2024,10.1158/2326-6066.cir-23-0851,https://pubmed.ncbi.nlm.nih.gov/38739030/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,40295408,The predictive value of maternal and neonatal inflammatory biomarkers for necrotizing enterocolitis.,2025,10.1007/s00431-025-06146-0,https://pubmed.ncbi.nlm.nih.gov/40295408/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,39225429,Nanotherapeutic Approaches of Interleukin-3 to Clear the α-Synuclein Pathology in Mouse Models of Parkinson's Disease.,2024,10.1002/advs.202405364,https://pubmed.ncbi.nlm.nih.gov/39225429/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,39525013,Screening of potential key pathogenic and intervention targets of low-grade glioma based on bioinformatics.,2024,10.21037/tcr-24-1662,https://pubmed.ncbi.nlm.nih.gov/39525013/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,42018150,Clinical and Molecular Characterization of a Rare EGFR cis Compound L833V/H835L Mutation in Non-Small Cell Lung Cancer.,2026,10.1158/2767-9764.crc-25-0831,https://pubmed.ncbi.nlm.nih.gov/42018150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,41543339,RRAS and RRAS2 Mutations Are Recurrent Oncogenic Drivers in Lung Cancer and Are Sensitive to the Pan-RAS Inhibitor RMC-6236.,2026,10.1158/1078-0432.ccr-25-2734,https://pubmed.ncbi.nlm.nih.gov/41543339/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,40038148,Identification and differential expression analysis of microRNAs in the liver and spleen tissues of Yunnan Zebu and Holstein cattle.,2025,10.1007/s11250-025-04357-z,https://pubmed.ncbi.nlm.nih.gov/40038148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,41067297,Transcriptome analysis reveals the gene expression changes in Strongyloides ratti tissue-migrating larvae.,2025,10.1016/j.meegid.2025.105839,https://pubmed.ncbi.nlm.nih.gov/41067297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,42475386,Structural and evolutionary insights into DAF-12 interactions with transcriptional coactivators in parasitic nematodes.,2026,10.1371/journal.ppat.1014073,https://pubmed.ncbi.nlm.nih.gov/42475386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,41380757,Developing vaccines against gastrointestinal nematodes of sheep - the model matters.,2026,10.1016/j.ijpara.2025.12.003,https://pubmed.ncbi.nlm.nih.gov/41380757/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,38043008,Correlation between IL3 signaling pathway-related genes and immune checkpoint inhibitor efficacy in patients with renal cell carcinoma.,2023,10.3233/cbm-230226,https://pubmed.ncbi.nlm.nih.gov/38043008/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,39379097,NSGS mice humanized with cord blood mononuclear cells show sustained and functional myeloid-lymphoid representation with limited graft-versus-host disease.,2024,10.1136/jitc-2024-009198,https://pubmed.ncbi.nlm.nih.gov/39379097/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,40598600,Engineering biomimetic bone marrow niche with gene modified mesenchymal stromal cells for ex vivo culture of human hematopoietic stem and progenitor cells.,2025,10.1186/s13287-025-04474-4,https://pubmed.ncbi.nlm.nih.gov/40598600/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,36968189,Targeting FMRP: A new window for cancer immunotherapy.,2023,10.1002/mco2.233,https://pubmed.ncbi.nlm.nih.gov/36968189/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,39861844,The &lt;i&gt;Meq&lt;/i&gt; Genes of Nigerian Marek's Disease Virus (MDV) Field Isolates Contain Mutations Common to Both European and US High Virulence Strains.,2024,10.3390/v17010056,https://pubmed.ncbi.nlm.nih.gov/39861844/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,38577038,Targeted review of IL36RN mutations in patients with generalised pustular psoriasis.,2024,10.1002/ski2.343,https://pubmed.ncbi.nlm.nih.gov/38577038/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,40901831,Identification of immune-related biomarkers associated with allergic rhinitis and development of a sample diagnostic model.,2025,10.1371/journal.pone.0329549,https://pubmed.ncbi.nlm.nih.gov/40901831/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,38952273,Do Not Forget the Granulocytic Compartment's Role in T cell-Mediated Antitumor Immunity.,2024,10.1158/2326-6066.cir-24-0395,https://pubmed.ncbi.nlm.nih.gov/38952273/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,40644785,"Exploring Biginelli hybrids in the AI-driven development of ruthenium complexes: Anticancer activity, DNA/HSA binding study, impacts on apoptosis and BCL-2/BCL-XL suppression.",2025,10.1016/j.jinorgbio.2025.112988,https://pubmed.ncbi.nlm.nih.gov/40644785/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,39776289,Clozapine Induces Agranulocytosis via Inflammatory and Hematopoietic Cytokine Induction of the JAK-STAT Signaling Pathway: Evidence From Network Pharmacology and Molecular Docking.,2025,10.1111/cns.70206,https://pubmed.ncbi.nlm.nih.gov/39776289/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,36285071,A Novel t(5;7)(q31;q21)/CDK6::IL3 in Immature T-cell Acute Lymphoblastic Leukemia With IL3 Expression and Eosinophilia.,2022,10.1097/hs9.0000000000000795,https://pubmed.ncbi.nlm.nih.gov/36285071/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL3,ENSG00000164399,Unsafe,36361533,IL3 Has a Detrimental Effect on Hematopoietic Stem Cell Self-Renewal in Transplantation Settings.,2022,10.3390/ijms232112736,https://pubmed.ncbi.nlm.nih.gov/36361533/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,42495641,Association of IL4I1&lt;sup&gt;+&lt;/sup&gt; M2-like macrophages in tumor microenvironment with poor prognosis in hepatocellular carcinoma: insights from bioinformatics and experimental validation.,2026,10.3389/fimmu.2026.1872272,https://pubmed.ncbi.nlm.nih.gov/42495641/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,41680858,Increased IL4I1 expression predicts poor survival and modulates the immune microenvironment in acute myeloid leukemia.,2026,10.1186/s12967-026-07814-x,https://pubmed.ncbi.nlm.nih.gov/41680858/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,41822356,Machine learning-derived AS and AIS scores leverage BCAA metabolism and IL4I1 activity for prognosis and tailored therapy in ccRCC.,2026,10.3389/fcell.2026.1720910,https://pubmed.ncbi.nlm.nih.gov/41822356/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,41458460,"IDO1, IL4I1: Novel Immune Checkpoints in Breast Cancer Tumor-Associated Macrophages.",2025,10.2147/bctt.s563049,https://pubmed.ncbi.nlm.nih.gov/41458460/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,42762693,Paired bulk transcriptomic analysis of recurrent glioblastoma with primary single-cell reference mapping.,2026,10.1016/j.tranon.2026.103031,https://pubmed.ncbi.nlm.nih.gov/42762693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,41167357,Transcriptomic analysis reveals the mechanism of viral modulation of host immunity facilitating calicivirus replication in Pelteobagrus fulvidraco.,2025,10.1016/j.dci.2025.105503,https://pubmed.ncbi.nlm.nih.gov/41167357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,41431173,IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR-Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma.,2026,10.1002/advs.202513606,https://pubmed.ncbi.nlm.nih.gov/41431173/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,39355609,IL-4-Induced Gene 1: A Potential Player in Myocardial Infarction.,2024,10.31083/j.rcm2509337,https://pubmed.ncbi.nlm.nih.gov/39355609/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,41008831,Proteomic Identification of IL4I1 as a Therapeutic Target in P53-Mutant Endometrial Cancer.,2025,10.3390/cancers17182986,https://pubmed.ncbi.nlm.nih.gov/41008831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,42096911,IL4I1+ macrophages drive hepatocellular carcinoma progression by responding to biomechanical cues.,2026,10.1016/j.jhepr.2026.101782,https://pubmed.ncbi.nlm.nih.gov/42096911/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,41537775,Conditional IL4I1 Inactivation Triggers Tumor-Associated Macrophage Reprogramming and CD8+ T-cell Reactivation to Control Melanoma Progression.,2026,10.1158/2326-6066.cir-24-1159,https://pubmed.ncbi.nlm.nih.gov/41537775/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,42755983,Multi-omics integration reveals macrophage polarization and ferroptosis as key mechanisms underlying kaempferol's therapeutic efficacy in peripheral artery disease.,2026,10.3389/fimmu.2026.1733284,https://pubmed.ncbi.nlm.nih.gov/42755983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,40071723,Tryptophan Metabolic Enzyme IL4I1 Inhibits Ferroptosis by Decreasing Ubiquitination of Nrf2 via I3P in Glioblastoma.,2025,10.1111/cpr.13816,https://pubmed.ncbi.nlm.nih.gov/40071723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,40559961,PM2.5 Induced Nasal Mucosal Barrier Dysfunction and Epithelial-Mesenchymal Transition to Promote Chronic Rhinosinusitis Through IL4I1-AhR Signaling Pathway.,2025,10.3390/toxics13060488,https://pubmed.ncbi.nlm.nih.gov/40559961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,40102177,Differential Effects of IL4I1 Protein on Lymphocytes From Healthy and Multiple Sclerosis Patients.,2025,10.1002/prp2.70062,https://pubmed.ncbi.nlm.nih.gov/40102177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,41690560,Emerging roles of IL4I1 in regulating tumor immunity and ferroptosis.,2026,10.1016/j.bbcan.2026.189553,https://pubmed.ncbi.nlm.nih.gov/41690560/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,42196276,The Tryptophan Paradox: From Microbiome-Mediated Homeostasis to Tumor-Driven Immune Escape.,2026,10.3390/ijms27104296,https://pubmed.ncbi.nlm.nih.gov/42196276/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,40769409,IL4I1 overexpression protects against nonalcoholic fatty liver disease in part by inhibiting the AKT/FOXO1 pathway-mediated Th17 cell differentiation.,2025,10.1016/j.jbc.2025.110560,https://pubmed.ncbi.nlm.nih.gov/40769409/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,42730796,Compensatory pathways in tryptophan metabolism and immune regulation following IDO inhibition.,2026,10.1007/s11033-026-12707-9,https://pubmed.ncbi.nlm.nih.gov/42730796/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,41741455,Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis.,2026,10.1038/s41467-026-69587-7,https://pubmed.ncbi.nlm.nih.gov/41741455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,42252303,Metabolic checkpoint blockade of IL4I1 by ZY-MY-111 reactivates CD8&lt;sup&gt;+&lt;/sup&gt; T cell immunity and suppresses tumor growth.,2026,10.1038/s41401-026-01843-4,https://pubmed.ncbi.nlm.nih.gov/42252303/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,41616522,Decoding IL4I1: The Core role of metabolism-driven immune regulation and new perspectives on disease targeting.,2026,10.1016/j.bioorg.2026.109544,https://pubmed.ncbi.nlm.nih.gov/41616522/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,42309384,IL4I1+ macrophage accumulation in advanced cutaneous T-cell lymphomas suggests a role in tumor immune escape.,2026,10.1016/j.jid.2026.05.033,https://pubmed.ncbi.nlm.nih.gov/42309384/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,40332319,Immunohistochemical Profiling of IDO1 and IL4I1 in Head and Neck Squamous Cell Carcinoma: Interplay for Metabolic Reprogramming?,2025,10.3390/ijms26083719,https://pubmed.ncbi.nlm.nih.gov/40332319/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,41308228,Prognostic and immunological significance of tryptophan metabolic enzymes across endometrial cancer molecular subtypes.,2026,10.1016/j.ygyno.2025.10.039,https://pubmed.ncbi.nlm.nih.gov/41308228/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,39844281,Knockout IL4I1 affects macrophages to improve poor efficacy of CD19 CAR-T combined with PD-1 inhibitor in relapsed/refractory diffuse large B-cell lymphoma.,2025,10.1186/s12967-024-06028-3,https://pubmed.ncbi.nlm.nih.gov/39844281/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,39216468,Collagen extracellular matrix promotes gastric cancer immune evasion by activating IL4I1-AHR signaling.,2024,10.1016/j.tranon.2024.102113,https://pubmed.ncbi.nlm.nih.gov/39216468/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,38873416,IL4I1: a novel molecular biomarker represents an inflamed tumor microenvironment and precisely predicts the molecular subtype and immunotherapy response of bladder cancer.,2024,10.3389/fphar.2024.1365683,https://pubmed.ncbi.nlm.nih.gov/38873416/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,25767141,Human spermatozoa possess an IL4I1 l-amino acid oxidase with a potential role in sperm function.,2015,10.1530/rep-14-0621,https://pubmed.ncbi.nlm.nih.gov/25767141/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,19436310,The novel immunosuppressive enzyme IL4I1 is expressed by neoplastic cells of several B-cell lymphomas and by tumor-associated macrophages.,2009,10.1038/leu.2008.380,https://pubmed.ncbi.nlm.nih.gov/19436310/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,17356132,Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation.,2007,10.1182/blood-2006-07-036210,https://pubmed.ncbi.nlm.nih.gov/17356132/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,12446450,Interleukin 4-induced gene 1 is activated in primary mediastinal large B-cell lymphoma.,2003,10.1182/blood-2002-07-2215,https://pubmed.ncbi.nlm.nih.gov/12446450/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL4I1,ENSG00000104951,Unsafe,12031486,Characterization of the human homolog of the IL-4 induced gene-1 (Fig1).,2002,10.1016/s0167-4781(02)00295-6,https://pubmed.ncbi.nlm.nih.gov/12031486/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,40922486,Spatial profiling reveals complex cellular responses of anti-IL5 treatment with mepolizumab in eosinophilic chronic rhinosinusitis with nasal polyposis.,2026,10.1093/jleuko/qiaf128,https://pubmed.ncbi.nlm.nih.gov/40922486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42414677,Effect of LY2109761 on TGF-β1/TGFβRI/Smad Pathway and Hepatic Fibrosis Cysts Formation in Rats Infected with Echinococcus granulosus: an In Vitro and In Vivo Study.,2026,10.1007/s11686-026-01324-y,https://pubmed.ncbi.nlm.nih.gov/42414677/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42585251,Eosinophil-associated intestinal immune responses following SARS-CoV-2 infection in K18-hACE2 mice.,2026,10.1371/journal.pone.0355607,https://pubmed.ncbi.nlm.nih.gov/42585251/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42402395,Topical administration of testosterone ameliorates atopic dermatitis of KFRS4 rats.,2026,10.1538/expanim.26-0044,https://pubmed.ncbi.nlm.nih.gov/42402395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42814219,Increased group 2 Innate lymphoid cell (ILC2) activity in pediatric familial mediterranean fever patients with spondyloarthropathy.,2026,10.1007/s10238-026-02260-x,https://pubmed.ncbi.nlm.nih.gov/42814219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42497191,IL5 rs2069812 and IL13 rs1800925 Genetic variants as key determinants of clinically relevant asthma phenotypes.,2026,10.1371/journal.pone.0354597,https://pubmed.ncbi.nlm.nih.gov/42497191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42061927,"Systemic modulation of toll-like receptors, cytokine polarization and inflammasome signaling in dogs with generalized demodicosis.",2026,10.1016/j.vetimm.2026.111127,https://pubmed.ncbi.nlm.nih.gov/42061927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42655930,Mepolizumab Modifies Blood Eosinophil Proteome and Transcriptome in Severe Eosinophilic Asthma.,2026,10.1111/all.70491,https://pubmed.ncbi.nlm.nih.gov/42655930/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42061467,Group 2 innate lymphoid cells: Where are we 15 years out?,2026,10.1016/j.jaci.2026.04.013,https://pubmed.ncbi.nlm.nih.gov/42061467/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42644013,"Early Life Exposure to PFOS or F‑53B is Associated with Increased Asthma Susceptibility in Offspring and Alterations in the Pulmonary Barrier, Immune Function, and Gut Microbiota.",2026,10.1021/envhealth.5c00473,https://pubmed.ncbi.nlm.nih.gov/42644013/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42524051,Choosing and switching biologics for patients with severe asthma: Real-world data from the German Asthma Net (GAN).,2026,10.5414/alx02636e,https://pubmed.ncbi.nlm.nih.gov/42524051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42549314,RAG1 deficiency durably alters dermal group 2 innate lymphoid cells and modifies contact hypersensitivity.,2026,10.3389/fimmu.2026.1859649,https://pubmed.ncbi.nlm.nih.gov/42549314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42789457,Update on biologic and small molecules treatments in pediatric allergic diseases.,2026,10.1111/pai.70454,https://pubmed.ncbi.nlm.nih.gov/42789457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42521715,Distinct NK cell dynamics in SARIFA positive colorectal cancer patients indicate persistent patient-intrinsic immune signatures after tumor resection.,2026,10.1038/s41598-026-63238-z,https://pubmed.ncbi.nlm.nih.gov/42521715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,40179741,Long noncoding RNA IDI2-AS1 modulates the expression of interleukin 5 in human cells.,2025,10.1016/j.bbrc.2025.151733,https://pubmed.ncbi.nlm.nih.gov/40179741/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42042546,MicroRNAs as Diagnostic and Therapeutic Biomarkers in Childhood Asthma: A Systematic Review with Bioinformatics Analysis.,2026,10.3390/jpm16040179,https://pubmed.ncbi.nlm.nih.gov/42042546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42079570,Spatial transcriptomics identifies fibroblast-T cell crosstalk as a driver of Th2 polarization in allergic rhinitis.,2026,10.3389/fimmu.2026.1788288,https://pubmed.ncbi.nlm.nih.gov/42079570/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42072084,Transcriptomic Analysis of Fermented Chinese Chive Selectively Attenuating Deoxynivalenol-Induced Ovarian Toxicity in Mice.,2026,10.3390/antiox15040442,https://pubmed.ncbi.nlm.nih.gov/42072084/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,40364837,Transcriptional co-regulator OCA-B/Pou2af1 restricts Th2 differentiation.,2025,10.3389/fimmu.2025.1548636,https://pubmed.ncbi.nlm.nih.gov/40364837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42137123,Introducing ICAM1 as a possible drug target in treatment of eosinophilic esophagitis.,2025,10.22037/ghfbb.v18ispecialissue.3235,https://pubmed.ncbi.nlm.nih.gov/42137123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,41776988,Characterization of Bronchiolitis and Vaccine-induced Enhanced Respiratory Disease in Syrian Hamsters Caused by Respiratory Syncytial Virus Infection.,2026,10.1093/infdis/jiag136,https://pubmed.ncbi.nlm.nih.gov/41776988/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42643717,Biological treatments for asthma and chronic obstructive pulmonary disease.,2026,10.1136/bmjmed-2025-002195,https://pubmed.ncbi.nlm.nih.gov/42643717/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42323367,The suppressive function of ILC2 cells is regulated by β2-adrenergic receptor signaling in breast cancer.,2026,10.1038/s41523-026-00990-5,https://pubmed.ncbi.nlm.nih.gov/42323367/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42914697,The transcriptional repressor Gfi1 is critical for the differentiation of pathogenic Th2 cells.,2026,10.1016/j.bbrc.2026.154767,https://pubmed.ncbi.nlm.nih.gov/42914697/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,39395838,Targeted inhibition of the IL5 axis for immune checkpoint inhibitors eosinophilic-induced adverse events.,2024,10.1136/jitc-2024-009658,https://pubmed.ncbi.nlm.nih.gov/39395838/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,38254772,Beyond PD(L)-1 Blockade in Microsatellite-Instable Cancers: Current Landscape of Immune Co-Inhibitory Receptor Targeting.,2024,10.3390/cancers16020281,https://pubmed.ncbi.nlm.nih.gov/38254772/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,39869499,"CSF cytokine, chemokine and injury biomarker profile of glial fibrillary acidic protein (GFAP) autoimmunity.",2025,10.1002/acn3.52305,https://pubmed.ncbi.nlm.nih.gov/39869499/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,41067871,Fractional exhaled nitric oxide and the response to prednisolone for asthma attacks in patients treated with anti-IL5/5Rα therapy: a prospective observational study.,2025,10.1183/13993003.01229-2025,https://pubmed.ncbi.nlm.nih.gov/41067871/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,41598525,Can Coexisting Allergic Rhinitis in Patients with Severe Eosinophilic Asthma Be a Prognostic Factor for Efficacy of Biological Therapy? Analysis of Eosinophilic Involvement.,2026,10.3390/jcm15020587,https://pubmed.ncbi.nlm.nih.gov/41598525/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,40823190,Cardiovascular safety of biologic therapies in patients with severe asthma: a nationwide cohort study in Belgium.,2025,10.1016/j.lanepe.2025.101420,https://pubmed.ncbi.nlm.nih.gov/40823190/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42762862,Efficacy and Tolerance of a Combination of Targeted Therapies Indicated for Asthma and Chronic Inflammatory Rheumatism.,2026,10.1016/j.jbspin.2026.106144,https://pubmed.ncbi.nlm.nih.gov/42762862/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,42323248,How to monitor response to biologics in children with severe asthma.,2026,10.1016/j.prrv.2026.05.009,https://pubmed.ncbi.nlm.nih.gov/42323248/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,39600395,"Biologics in allergology and clinical immunology: Update on therapies for atopic diseases, urticaria, and angioedema and on safety aspects focusing on hypersensitivity reactions.",2024,10.5414/alx02533e,https://pubmed.ncbi.nlm.nih.gov/39600395/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,40115529,Treatment and Monitoring of Eosinophilic Fasciitis.,2025,10.1007/s40674-024-00222-6,https://pubmed.ncbi.nlm.nih.gov/40115529/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,40443809,Using Olink Proteomics to Identify Inflammatory Biomarkers in the Cerebrospinal Fluid in Guillain-Barré Syndrome.,2025,10.2147/jir.s507515,https://pubmed.ncbi.nlm.nih.gov/40443809/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL5,ENSG00000113525,Unsafe,32211550,Identification of a novel splice variant for mouse and human interleukin-5.,2020,10.1016/j.heliyon.2020.e03586,https://pubmed.ncbi.nlm.nih.gov/32211550/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,42457686,IL7-Receptor-Targeted CAR T-Cell Therapy for T-Cell Acute Lymphoblastic Leukemia.,2026,10.1038/s41467-026-75675-5,https://pubmed.ncbi.nlm.nih.gov/42457686/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,42533289,Gamma Delta T Cells in Shrimp Allergy Express a Unique Cytotoxic Cytokine Profile.,2026,10.1002/clt2.70189,https://pubmed.ncbi.nlm.nih.gov/42533289/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,42434754,Identification of potential vinorelbine-associated prognostic genes in breast cancer through integrative bioinformatics and experimental validation.,2026,10.3389/fonc.2026.1855523,https://pubmed.ncbi.nlm.nih.gov/42434754/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,41970824,An AviTag/BirA Platform for IL7: Minimized Activity Loss over Random Biotinylation.,2026,10.1021/acsomega.5c12146,https://pubmed.ncbi.nlm.nih.gov/41970824/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,42189877,PiggyBac-Engineered Membrane-Bound IL7 TILs Combined with Anti-PD-1 Antibody Demonstrates Efficacy in Recurrent Ovarian Cancer: A First-in-Human Phase I Trial.,2026,10.1158/1078-0432.ccr-25-4130,https://pubmed.ncbi.nlm.nih.gov/42189877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,40386183,IL7-IL7R Interaction Mediates Fibroblast-Driven Macrophage-to-Osteoclast Differentiation in Periodontitis.,2025,10.2147/jir.s524284,https://pubmed.ncbi.nlm.nih.gov/40386183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,41753174,Association of &lt;i&gt;IL7&lt;/i&gt; rs16906115 Polymorphism with Immune-Related Adverse Events in Patients with Advanced Lung Cancer Undergoing Immunotherapy.,2026,10.3390/jcm15041486,https://pubmed.ncbi.nlm.nih.gov/41753174/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,41880597,"NT-I7, a Long-Acting Interleukin 7, Increases Lymphocyte Counts and Induces CD8+ T-cell Clonotype Expansion in Patients with Newly Diagnosed High-Grade Gliomas.",2026,10.1158/1078-0432.ccr-25-2953,https://pubmed.ncbi.nlm.nih.gov/41880597/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,42824315,Clusterin expression and germinal center morphometry help distinguish idiopathic multicentric castleman disease from select lymphadenopathies.,2026,10.3389/fimmu.2026.1872505,https://pubmed.ncbi.nlm.nih.gov/42824315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,42185247,Insulin enables acquisition of the IL7R&lt;sup&gt;+&lt;/sup&gt; memory phenotype in PD1&lt;sup&gt;+&lt;/sup&gt; T cells in RA tissues.,2026,10.1038/s41419-026-08916-6,https://pubmed.ncbi.nlm.nih.gov/42185247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,41523140,"IL7-TBRII, a Dual Cytokine Modulator Targeting IL-7 and TGF-β Pathways, Inhibits Tumor Progression and Metastasis.",2025,10.4110/in.2025.25.e42,https://pubmed.ncbi.nlm.nih.gov/41523140/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,42726640,Endothelial PERK restricts lymphoid regeneration by reducing DLL4-NOTCH3 signaling at the Pre-B niche.,2026,10.1016/j.celrep.2026.117953,https://pubmed.ncbi.nlm.nih.gov/42726640/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,42778197,Targeting pancreatic cancer with adenoviral vectors equipped with transgenes.,2026,10.1158/1535-7163.mct-25-1231,https://pubmed.ncbi.nlm.nih.gov/42778197/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,42298246,Ovarian localization drives IL-7R-dependent CD8 coreceptor expression in peripheral double-negative T cells.,2026,10.1007/s00018-026-06295-x,https://pubmed.ncbi.nlm.nih.gov/42298246/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,42313402,Cerebrospinal Fluid Transcriptional Immune Pathways Linked to Survival in HIV-Associated Tuberculous Meningitis.,2026,10.1093/infdis/jiag313,https://pubmed.ncbi.nlm.nih.gov/42313402/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,42570563,"Serum, milk and saliva cytokines in canine pseudopregnancy. A pilot study.",2026,10.1016/j.rvsc.2026.106351,https://pubmed.ncbi.nlm.nih.gov/42570563/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,38966234,Interleukin-7-based identification of liver lymphatic endothelial cells reveals their unique structural features.,2024,10.1016/j.jhepr.2024.101069,https://pubmed.ncbi.nlm.nih.gov/38966234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,39677294,A Targeted Proteomics Approach Reveals a Serum Protein Signature as a Diagnostic Biomarker for Colorectal Cancer.,2024,10.2147/jir.s492356,https://pubmed.ncbi.nlm.nih.gov/39677294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,40857939,Investigating cytotoxic and inflammatory human IL-7 receptor low effector memory CD8&lt;sup&gt;+&lt;/sup&gt; T cells in lupus.,2025,10.1016/j.ebiom.2025.105898,https://pubmed.ncbi.nlm.nih.gov/40857939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,42209704,Atypical cytokine profiles in people on the autism spectrum: a comprehensive systematic review and meta-analysis including 54 cytokines.,2026,10.1038/s41380-026-03659-4,https://pubmed.ncbi.nlm.nih.gov/42209704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,41266303,Dynamic transcriptional immune landscape in response to NK-cell therapy combined with gemcitabine plus S-1 in advanced pancreatic cancer: a phase 1b/2 trial.,2025,10.1038/s41392-025-02488-1,https://pubmed.ncbi.nlm.nih.gov/41266303/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,41899506,Co-Expression of IL-2 Enhances the Efficacy of FLT3-CAR-γδT Cells in Acute Myeloid Leukemia.,2026,10.3390/cancers18060901,https://pubmed.ncbi.nlm.nih.gov/41899506/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,41542752,Targeted computational design of an interleukin-7 superkine with enhanced folding efficiency and immunotherapeutic efficacy.,2026,10.7554/elife.107671,https://pubmed.ncbi.nlm.nih.gov/41542752/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,39443955,Membrane-bound IL-7 immobilized by the CD8 transmembrane region improves efficacy of CD19 CAR-T cell therapy.,2024,10.1186/s12943-024-02154-0,https://pubmed.ncbi.nlm.nih.gov/39443955/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,38554147,IL7 in combination with radiotherapy stimulates a memory T-cell response to improve outcomes in HNSCC models.,2024,10.1007/s00262-024-03664-y,https://pubmed.ncbi.nlm.nih.gov/38554147/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,39240078,Therapeutic Efficacy of IL7/CCL19-Expressing CAR-T Cells in Intractable Solid Tumor Models of Glioblastoma and Pancreatic Cancer.,2024,10.1158/2767-9764.crc-24-0226,https://pubmed.ncbi.nlm.nih.gov/39240078/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,39186002,Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain.,2024,10.1158/2767-9764.crc-24-0286,https://pubmed.ncbi.nlm.nih.gov/39186002/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IL7,ENSG00000104432,Unsafe,39630308,Identification and construction of prognostic clusters and risk-prognosis model based on aging-immune related genes in bladder cancer.,2024,10.1007/s12672-024-01655-0,https://pubmed.ncbi.nlm.nih.gov/39630308/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMMP1L,ENSG00000148950,Unsafe,34149809,Leveraging Methylation Alterations to Discover Potential Causal Genes Associated With the Survival Risk of Cervical Cancer in TCGA Through a Two-Stage Inference Approach.,2021,10.3389/fgene.2021.667877,https://pubmed.ncbi.nlm.nih.gov/34149809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMMP1L,ENSG00000148950,Unsafe,26449484,Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.,2015,10.1186/s13073-015-0225-4,https://pubmed.ncbi.nlm.nih.gov/26449484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMMP1L,ENSG00000148950,Unsafe,25628759,"A novel 11p13 microdeletion encompassing PAX6 in a Chinese Han family with aniridia, ptosis and mental retardation.",2015,10.1186/s13039-015-0110-2,https://pubmed.ncbi.nlm.nih.gov/25628759/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMMP1L,ENSG00000148950,Unsafe,30572005,Deletion distal to the PAX6 coding region reveals a novel basis for familial cosegregation of aniridia and diabetes mellitus.,2019,10.1016/j.diabres.2018.12.002,https://pubmed.ncbi.nlm.nih.gov/30572005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMMP1L,ENSG00000148950,Unsafe,21321669,A 556 kb deletion in the downstream region of the PAX6 gene causes familial aniridia and other eye anomalies in a Chinese family.,2011,,https://pubmed.ncbi.nlm.nih.gov/21321669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMMP1L,ENSG00000148950,Unsafe,21635818,Mitochondrial inhibition during preimplantation embryogenesis shifts the transcriptional profile of fetal mouse brain.,2011,10.1071/rd10292,https://pubmed.ncbi.nlm.nih.gov/21635818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMMP1L,ENSG00000148950,Unsafe,26419218,A familial pericentric inversion of chromosome 11 associated with a microdeletion of 163 kb and microduplication of 288 kb at 11p13 and 11q22.3 without aniridia or eye anomalies.,2016,10.1002/ajmg.a.37388,https://pubmed.ncbi.nlm.nih.gov/26419218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42567885,IGF2BP3-mediated regulation of the RNA isoform and modification landscape in pancreatic cancer.,2026,10.1038/s41388-026-03933-3,https://pubmed.ncbi.nlm.nih.gov/42567885/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42650103,RNA Splicing Dysregulation in Parkinson's Disease.,2026,10.3390/genes17080911,https://pubmed.ncbi.nlm.nih.gov/42650103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42553678,Gut-testis axis: how microbiota influence male reproductive health.,2026,10.2478/abm-2026-0017,https://pubmed.ncbi.nlm.nih.gov/42553678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,41732172,Proteome-scale autoantibody profiling in PSC: Associations with clinical phenotypes and evidence for neuroendocrine deregulations.,2026,10.1016/j.jhepr.2025.101719,https://pubmed.ncbi.nlm.nih.gov/41732172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42723868,"The double-edged role of SPAG6 in male reproductive toxicity: pro-invasive in leukemia, protective in germ cells.",2026,10.3389/fmed.2026.1855817,https://pubmed.ncbi.nlm.nih.gov/42723868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42001173,Tissue-specific gene dosage disruption is a key feature and pathogenic mechanism of structural variants in the human genome.,2026,10.1186/s13073-026-01653-7,https://pubmed.ncbi.nlm.nih.gov/42001173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42253927,Beyond the Known and Established Neurodegenerative Effects: Roles of APOE Across a Wide Spectrum of Pathophysiological Condition.,2026,10.1002/mco2.70789,https://pubmed.ncbi.nlm.nih.gov/42253927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42424014,Dose-dependent effect of curcumin nanomicelle on autophagy signaling in testis; a study on normal Wistar rats.,2026,10.1007/s11033-026-12189-9,https://pubmed.ncbi.nlm.nih.gov/42424014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42882837,H3K27M Mutation Modulates the Antigenic Landscape in Diffuse Midline Glioma.,2026,10.3390/cancers18193142,https://pubmed.ncbi.nlm.nih.gov/42882837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42014698,Isoform-specific m6A deposition and coordinated splicing shape mammalian transcriptome evolution.,2026,10.1038/s41467-026-72124-1,https://pubmed.ncbi.nlm.nih.gov/42014698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,41586246,Impact of selenium and selenoproteins on idiopathic male infertility: a comprehensive review.,2025,10.3389/fnut.2025.1702028,https://pubmed.ncbi.nlm.nih.gov/41586246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42426023,Tissue-resident neutrophils serve homeostatic and immunological functions in embryos.,2026,10.1038/s41467-026-75410-0,https://pubmed.ncbi.nlm.nih.gov/42426023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42811676,Androgens Modulate Tumor-Immune Interactions in Testicular Germ Cell Tumors.,2026,10.1111/andr.70402,https://pubmed.ncbi.nlm.nih.gov/42811676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42116327,"The relationships between diabetic male infertility, diabetic cognitive impairment, and the neuroendocrine-immune network: A review.",2026,10.1097/md.0000000000048631,https://pubmed.ncbi.nlm.nih.gov/42116327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42637859,Chronic Toxoplasma gondii infection and its influence on semen analysis in rats: controlled experimental animal study.,2026,10.1038/s41598-026-62773-z,https://pubmed.ncbi.nlm.nih.gov/42637859/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42754569,Alternative tandem transcription initiation links noncoding variants to human disease through translational control.,2026,10.1038/s41467-026-76741-8,https://pubmed.ncbi.nlm.nih.gov/42754569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42210743,Micro- and nanoplastics in the human genitourinary system: oncological impact - a systematic review.,2026,10.1111/bju.70326,https://pubmed.ncbi.nlm.nih.gov/42210743/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42476817,Functional divergence of Capicua isoforms explains differential tissue vulnerability in neurological disease.,2026,10.1101/gad.353596.125,https://pubmed.ncbi.nlm.nih.gov/42476817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42505568,From Insight to Impact: Spotlight on the Potential Implications of the Neuronal Nitric Oxide Synthase Isoenzyme (nNOS) in Experimental Chronic Toxoplasmosis.,2026,10.3390/diseases14070240,https://pubmed.ncbi.nlm.nih.gov/42505568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42784045,"Characterization of Dystrophin-Related Syndromes: Carriers, DMD, and BMD.",2026,10.3390/muscles5030060,https://pubmed.ncbi.nlm.nih.gov/42784045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42792661,"Immunotherapy for Digestive System Cancers: Progress, Challenges, and Future Directions.",2026,10.3390/biomedicines14091919,https://pubmed.ncbi.nlm.nih.gov/42792661/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42206048,Therapeutic cancer vaccines: navigating clinical translation and multimodal synergy.,2026,10.3389/fimmu.2026.1818121,https://pubmed.ncbi.nlm.nih.gov/42206048/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42676608,"Optimizing immunotherapy-radiotherapy synergy in triple-negative breast cancer: mechanisms, clinical evidence, and therapeutic windows.",2026,10.3389/fimmu.2026.1861526,https://pubmed.ncbi.nlm.nih.gov/42676608/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42654486,Impact of COVID-19 Vaccination on Patients with Non-Small Cell Lung Cancer Receiving First-Line Immune Checkpoint Inhibitor Therapy: Real-World Evidence from Romania.,2026,10.3390/medicina62081588,https://pubmed.ncbi.nlm.nih.gov/42654486/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42449707,"Rational Immune Checkpoint Inhibitor-Based Combination Immunotherapy in Cancer: Mechanistic Design, Biomarker Selection, and Implications for Oncology Pharmacy.",2026,10.3390/cancers18132163,https://pubmed.ncbi.nlm.nih.gov/42449707/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42344931,Vaccines as treatment for melanoma: an update review.,2026,10.3389/fimmu.2026.1724490,https://pubmed.ncbi.nlm.nih.gov/42344931/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42820064,The Immune Checkpoint Inhibitors Journey: From Early Promise to Lasting Impact.,2026,10.36401/jipo-26-12,https://pubmed.ncbi.nlm.nih.gov/42820064/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42777327,Safety profile of BCG with or without immunotherapy in non-muscle-invasive bladder cancer (NMIBC): a systematic review and meta-analysis.,2026,10.1016/j.esmoop.2026.108529,https://pubmed.ncbi.nlm.nih.gov/42777327/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42720126,The IPTA Nashville Consensus Conference on Post-Transplant Lymphoproliferative Disorders After Solid Organ Transplantation in Children: Updates on Classification and Prevention-2026.,2026,10.1111/petr.70445,https://pubmed.ncbi.nlm.nih.gov/42720126/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42052515,Nanotechnology-Assisted Co-Delivery of Immunotherapeutic Agents for Targeting Ovarian Cancer: Prospects and Challenges.,2026,10.2147/ijn.s603950,https://pubmed.ncbi.nlm.nih.gov/42052515/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42099874,Oncolytic viruses and neoantigen vaccines: opportunities and challenges in priming antitumour immunity.,2026,10.1016/j.lanepe.2026.101659,https://pubmed.ncbi.nlm.nih.gov/42099874/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42366313,Anti-PD-1 Combinations: Triplets and Beyond.,2026,10.1007/s11912-026-01788-1,https://pubmed.ncbi.nlm.nih.gov/42366313/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,41971684,mRNA vaccines in oncology: personalized cancer immunization and neoantigen targeting.,2026,10.1080/23723556.2026.2652613,https://pubmed.ncbi.nlm.nih.gov/41971684/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42614773,Immune Suppression and Somatic Mutation in Endometriosis - An Opportunity for Personalized Immunotherapy.,2026,10.2147/ijwh.s629578,https://pubmed.ncbi.nlm.nih.gov/42614773/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,41878443,"Safety and immunologic impact of neoadjuvant/adjuvant GVAX, cyclophosphamide, pembrolizumab, and anti-CSF1R agent IMC-CS4 in pancreatic adenocarcinoma.",2026,10.3389/fimmu.2026.1715761,https://pubmed.ncbi.nlm.nih.gov/41878443/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,41924551,Key Considerations for Targeting &lt;i&gt;KRAS&lt;/i&gt; in Pancreatic Cancer: Potential Impact on the Treatment Paradigm.,2026,10.2147/dddt.s559325,https://pubmed.ncbi.nlm.nih.gov/41924551/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,41984335,Next-generation neoantigen mRNA vaccines: Immuno-engineering strategies for precision cancer immunotherapy.,2026,10.1007/s13402-026-01199-1,https://pubmed.ncbi.nlm.nih.gov/41984335/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42756099,T-cell redirecting therapies in lung cancer - a comprehensive analysis of clinical trials.,2026,10.3389/fimmu.2026.1917770,https://pubmed.ncbi.nlm.nih.gov/42756099/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,41881999,Cancer vaccines and RNA therapeutics: exploring the impact of microRNAs.,2026,10.1038/s41541-026-01425-9,https://pubmed.ncbi.nlm.nih.gov/41881999/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,42820288,Expanding the therapeutic scope of PARP inhibitors in breast cancer: current indications and future directions.,2026,10.1172/jci207632,https://pubmed.ncbi.nlm.nih.gov/42820288/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,11244491,Human homolog of the mouse imprinted gene Impact resides at the pericentric region of chromosome 18 within the critical region for bipolar affective disorder.,2001,10.1038/sj.mp.4000799,https://pubmed.ncbi.nlm.nih.gov/11244491/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IMPACT,ENSG00000154059,Unsafe,11116084,Comparative genome analysis of the mouse imprinted gene impact and its nonimprinted human homolog IMPACT: toward the structural basis for species-specific imprinting.,2000,10.1101/gr.139200,https://pubmed.ncbi.nlm.nih.gov/11116084/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,37286744,TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m7G methylation of ATF5 mRNA.,2023,10.1038/s41418-023-01179-0,https://pubmed.ncbi.nlm.nih.gov/37286744/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,36425530,The roles of ING5 in cancer: A tumor suppressor.,2022,10.3389/fcell.2022.1012179,https://pubmed.ncbi.nlm.nih.gov/36425530/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,36585686,"Genome-wide placental DNA methylations in fetal overgrowth and associations with leptin, adiponectin and fetal growth factors.",2022,10.1186/s13148-022-01412-6,https://pubmed.ncbi.nlm.nih.gov/36585686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,25525809,Maintenance of leukemia-initiating cells is regulated by the CDK inhibitor Inca1.,2014,10.1371/journal.pone.0115578,https://pubmed.ncbi.nlm.nih.gov/25525809/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,21540187,Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.,2011,10.1074/jbc.m110.203471,https://pubmed.ncbi.nlm.nih.gov/21540187/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,28338058,The role of CREB3L4 in the proliferation of prostate cancer cells.,2017,10.1038/srep45300,https://pubmed.ncbi.nlm.nih.gov/28338058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,21750715,The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects.,2011,10.1371/journal.pone.0021505,https://pubmed.ncbi.nlm.nih.gov/21750715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,18756329,"A novel testis protein, RSB-66, interacting with INCA1 (inhibitor of Cdk interacting with cyclin A1).",2008,10.1139/o08-072,https://pubmed.ncbi.nlm.nih.gov/18756329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,24659297,Dysregulated expression of lipid storage and membrane dynamics factors in Tia1 knockout mouse nervous tissue.,2014,10.1007/s10048-014-0397-x,https://pubmed.ncbi.nlm.nih.gov/24659297/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,25265349,Elucidating the roles of miR-372 in cell proliferation and apoptosis of nasopharyngeal carcinoma TW01 cells.,2014,,https://pubmed.ncbi.nlm.nih.gov/25265349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,15159402,Identification of interaction partners and substrates of the cyclin A1-CDK2 complex.,2004,10.1074/jbc.m401708200,https://pubmed.ncbi.nlm.nih.gov/15159402/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,15800920,Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development.,2005,10.1002/ijc.21034,https://pubmed.ncbi.nlm.nih.gov/15800920/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,22385097,Methylome of fetal and maternal monocytes and macrophages at the feto-maternal interface.,2012,10.1111/j.1600-0897.2012.01108.x,https://pubmed.ncbi.nlm.nih.gov/22385097/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,16148011,Inhibition of the calcineurin-NFAT interaction by small organic molecules reflects binding at an allosteric site.,2005,10.1074/jbc.m502247200,https://pubmed.ncbi.nlm.nih.gov/16148011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,20028601,Trends in food and nutritional intakes of French adults from 1999 to 2007: results from the INCA surveys.,2010,10.1017/s0007114509992625,https://pubmed.ncbi.nlm.nih.gov/20028601/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,18772863,Are eating occasions and their energy content related to child overweight and socioeconomic status?,2008,10.1038/oby.2008.404,https://pubmed.ncbi.nlm.nih.gov/18772863/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,19814837,Trends in food intake in French children from 1999 to 2007: results from the INCA (étude Individuelle Nationale des Consommations Alimentaires) dietary surveys.,2010,10.1017/s0007114509992078,https://pubmed.ncbi.nlm.nih.gov/19814837/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,18030311,Is food portion size a risk factor of childhood overweight?,2009,10.1038/sj.ejcn.1602958,https://pubmed.ncbi.nlm.nih.gov/18030311/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INCA1,ENSG00000196388,Unsafe,18608497,Assessment of dietary exposure of nitrate and nitrite in France.,2008,10.1080/02652030801946561,https://pubmed.ncbi.nlm.nih.gov/18608497/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,42589455,Multi-Omics Analysis of the Effects of &lt;i&gt;INHA&lt;/i&gt; and &lt;i&gt;FNDC1&lt;/i&gt; on Clutch Length in Zi Geese.,2026,10.3390/ijms27156798,https://pubmed.ncbi.nlm.nih.gov/42589455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,41788624,Spinal cord injury-induced overflow incontinence reshapes the activin-follistatin-inhibin axis in mouse bladder and kidney.,2026,10.3389/fmolb.2026.1752395,https://pubmed.ncbi.nlm.nih.gov/41788624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,41090758,Fyn-T Kinase Regulates DHA-Induced Pyroptosis in Immortalized Normal Human Astrocytes.,2025,10.3390/cells14191530,https://pubmed.ncbi.nlm.nih.gov/41090758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,42302511,Identification and functional validation of P4HA1 and INHA as hypoxia-responsive biomarkers in preeclampsia.,2026,10.1016/j.placenta.2026.06.002,https://pubmed.ncbi.nlm.nih.gov/42302511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,42450668,Screening and Preliminary Identification of Inhibin α Subunit-Specific Nanobodies Through High-Throughput Sequencing Combined with Mass Spectrometry.,2026,10.3390/ani16131961,https://pubmed.ncbi.nlm.nih.gov/42450668/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,42450741,Integrative Transcriptomic and Metabolomic Analysis Reveal Mechanisms Underlying Differential Fecundity in Yangtze River Delta White Goat.,2026,10.3390/ani16132034,https://pubmed.ncbi.nlm.nih.gov/42450741/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,42910207,Two Case Reports of Drug-Resistant Tuberculous Pleurisy in Children: Thoracoscopic Pleural Biopsy and PCR-Based Drug-Resistance Testing.,2026,10.2147/idr.s653638,https://pubmed.ncbi.nlm.nih.gov/42910207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,42151375,"Association of pyrazinamide resistance in Mycobacterium tuberculosis with mutations in rpoB, katG, and inhA genes.",2026,10.1038/s41598-026-53296-8,https://pubmed.ncbi.nlm.nih.gov/42151375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,42037600,"Association of &lt;i&gt;katG&lt;/i&gt;, &lt;i&gt;inhA,&lt;/i&gt; and &lt;i&gt;AhpC&lt;/i&gt; Mutations with Isoniazid Resistance of &lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt; in Pulmonary Tuberculosis Patients from Nanjing, China.",2026,10.1177/10766294261446052,https://pubmed.ncbi.nlm.nih.gov/42037600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,42708318,"Computational Discovery of Phytochemicals Targeting InhA of Mycobacterium tuberculosis: Insights from Molecular Docking, MMGBSA, ADME Profiling, and Molecular Dynamics Simulations.",2026,10.2174/0115734099478541260828062328,https://pubmed.ncbi.nlm.nih.gov/42708318/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,39337600,NR5A1/SF-1 Collaborates with Inhibin α and the Androgen Receptor.,2024,10.3390/ijms251810109,https://pubmed.ncbi.nlm.nih.gov/39337600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,42760852,"Design, Synthesis, Antimycobacterial Evaluation, and In Silico Investigation of Benzisothiazole-Based Hydrazide Derivatives as Potential Anti-Tuberculosis Agents.",2026,10.1111/cbdd.70405,https://pubmed.ncbi.nlm.nih.gov/42760852/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,42417797,The potential of molecular testing and mutation analysis for detecting isoniazid and rifampicin-resistant Mycobacterium tuberculosis in Thailand.,2026,10.1590/s1678-9946202668040,https://pubmed.ncbi.nlm.nih.gov/42417797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,38847724,Study on the value of Inhibin B in the diagnosis of nasopharyngeal carcinoma and its correlation with traditional Chinese medicine syndromes: An observational study.,2024,10.1097/md.0000000000038416,https://pubmed.ncbi.nlm.nih.gov/38847724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,42741666,Development of isonicotinoyl-azole hybrids as potential InhA inhibitors for anti-tubercular activity.,2026,10.1039/d6md00438e,https://pubmed.ncbi.nlm.nih.gov/42741666/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,41921200,Molecular and pharmacological impacts of phytochemicals on the enoyl-acyl carrier protein reductase: potential therapeutic implications in tuberculosis.,2026,10.1093/intbio/zyag007,https://pubmed.ncbi.nlm.nih.gov/41921200/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,41868180,"Investigation of Potent Anti-&lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt; Agents Derived from Pyridine Derivatives Targeting the Enoyl Acyl Carrier Protein Reductase (InhA): Design, Synthesis, and Computational Analysis.",2026,10.2147/dddt.s566020,https://pubmed.ncbi.nlm.nih.gov/41868180/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,42318538,Discovery of novel InhA inhibitors through structural bioinformatics and machine learning-driven QSAR screening of natural products.,2026,10.1093/biomethods/bpag015,https://pubmed.ncbi.nlm.nih.gov/42318538/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,41647443,"Design, synthesis, and molecular modeling of novel thiazolopyridine-based inhibitors of enoyl acyl carrier protein reductase (InhA) as anti-&lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt; agents.",2026,10.1039/d5md00997a,https://pubmed.ncbi.nlm.nih.gov/41647443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,40114606,"Obesity alters testicular gene expression in mice, monkeys and humans.",2025,10.1017/s0967199425000061,https://pubmed.ncbi.nlm.nih.gov/40114606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,42767000,"Exploration of novel indolo[2,3-b]quinoxaline hybrids as InhA inhibitors: A multi-disciplinary approach involving synthesis, antimycobacterial evaluation and computational studies.",2026,10.1016/j.ejmech.2026.119317,https://pubmed.ncbi.nlm.nih.gov/42767000/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,42641843,Genetic diversity of clinical Mycobacterium bovis BCG isolates from an immunocompromised patient with BCG infection.,2026,10.1016/j.meegid.2026.106014,https://pubmed.ncbi.nlm.nih.gov/42641843/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,40697459,"Structure-based design, synthesis, computational screening and biological evaluation of novel pyrrole fused pyrimidine derivatives targeting InhA enzyme.",2025,10.1039/d5ra03004h,https://pubmed.ncbi.nlm.nih.gov/40697459/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,41244927,Molecular docking and pharmacokinetic studies of bioactive compounds from medicinal plants as promising inhibitory agents against &lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt; enoyl-acyl carrier protein (ACP)-reductase (InhA).,2025,10.1007/s40203-025-00472-9,https://pubmed.ncbi.nlm.nih.gov/41244927/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,41572760,Targeting InhA for Tuberculosis Therapy: A Review of Recent Advances in Enzyme Inhibition and Drug Development.,2026,10.2174/0113894501399928251216164517,https://pubmed.ncbi.nlm.nih.gov/41572760/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,40729021,A Novel Hypoxia-Immune Signature for Gastric Cancer Prognosis and Immunotherapy: Insights from Bulk and Single-Cell RNA-Seq.,2025,10.3390/cimb47070552,https://pubmed.ncbi.nlm.nih.gov/40729021/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,40926686,Rationally Designed InhA Inhibitors: A Comparative Anti-Tubercular Activity Study of Sulfonate Esters of Isoniazid Hydrazones and Their Structurally Flexible Benzyl Analogues.,2025,10.1111/cbdd.70171,https://pubmed.ncbi.nlm.nih.gov/40926686/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,41099073,"Synthesis and biological evaluation of furan-1,3,4-oxadiazole as antitubercular, antibacterial, and antioxidant agents.",2025,10.1080/17568919.2025.2570972,https://pubmed.ncbi.nlm.nih.gov/41099073/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,42072057,Targeting Inhibin Enhances Wagyu Oocyte Competence and Embryo Quality: A Comparative Study of In Vivo Immunization and In Vitro Antibody Supplementation.,2026,10.3390/antiox15040414,https://pubmed.ncbi.nlm.nih.gov/42072057/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,40901448,"Isoniazid-rhodanine molecular hybrids: design, synthesis, antimycobacterial activity and computational validation.",2025,10.1039/d5ra03641k,https://pubmed.ncbi.nlm.nih.gov/40901448/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,39279702,"Computational Exploration of Isatin Derivatives for InhA Inhibition in Tuberculosis: Molecular Docking, MD Simulations and ADMET Insights.",2025,10.2174/0115734099333313240909103833,https://pubmed.ncbi.nlm.nih.gov/39279702/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,40687024,Designing Novel InhA Inhibitors for Antituberculosis Agents Using ab Initio Fragment Molecular Orbital Calculations.,2025,10.1021/acsomega.5c02912,https://pubmed.ncbi.nlm.nih.gov/40687024/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,40436325,Hybrid virtual screening identifies dipyrazole carboxamide derivatives as novel direct InhA inhibitors with antitubercular activity.,2025,10.1016/j.bbagen.2025.130827,https://pubmed.ncbi.nlm.nih.gov/40436325/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,39345183,Contribution of direct InhA inhibitors to novel drug regimens in a mouse model of tuberculosis.,2024,10.1128/aac.00357-24,https://pubmed.ncbi.nlm.nih.gov/39345183/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,42817100,"1,2,3-Triazole-Based Hybrids as Emerging Therapeutic Agents: Advances in Drug Design, Computational Studies, and Biological Applications.",2026,10.2174/0113895575488034260914054438,https://pubmed.ncbi.nlm.nih.gov/42817100/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INHA,ENSG00000123999,Unsafe,9506758,Loss of the expression and localization of inhibin alpha-subunit in high grade prostate cancer.,1998,10.1210/jcem.83.3.4640,https://pubmed.ncbi.nlm.nih.gov/9506758/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,42863647,Polystyrene nanoplastics perturb macrophage mitochondrial homeostasis and inflammatory responses: Evidence implicating CPEB4.,2026,10.1016/j.envpol.2026.129326,https://pubmed.ncbi.nlm.nih.gov/42863647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,39863741,A cross-tissue transcriptome-wide association study identifies new susceptibility genes for benign prostatic hyperplasia.,2025,10.1038/s41598-025-87651-y,https://pubmed.ncbi.nlm.nih.gov/39863741/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,40918094,Integrative scRNA-seq and transcriptomic analysis initially reveals monocyte/macrophage activation drives EV-A71-induced immune dysregulation and neural injury in severe HFMD.,2025,10.3389/fimmu.2025.1620633,https://pubmed.ncbi.nlm.nih.gov/40918094/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,40927753,PRMT1-Mediated PARP1 Methylation Drives Lung Metastasis and Chemoresistance via P65 Activation in Triple-Negative Breast Cancer.,2025,10.34133/research.0854,https://pubmed.ncbi.nlm.nih.gov/40927753/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,39905263,Machine learning-random forest model was used to construct gene signature associated with cuproptosis to predict the prognosis of gastric cancer.,2025,10.1038/s41598-025-88812-9,https://pubmed.ncbi.nlm.nih.gov/39905263/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,37758722,Comprehensive analysis of TLX2 in pan cancer as a prognostic and immunologic biomarker and validation in ovarian cancer.,2023,10.1038/s41598-023-42171-5,https://pubmed.ncbi.nlm.nih.gov/37758722/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,36062142,Integrative analysis of DNA methylation and gene expression data for the diagnosis and underlying mechanism of Parkinson's disease.,2022,10.3389/fnagi.2022.971528,https://pubmed.ncbi.nlm.nih.gov/36062142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,36896429,The Key Roles of Mycobacterium tuberculosis FadD23 C-terminal Domain in Catalytic Mechanisms.,2023,10.3389/fmicb.2023.1090534,https://pubmed.ncbi.nlm.nih.gov/36896429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,32112393,A GLI3 variant leading to polydactyly in heterozygotes and Pallister-Hall-like syndrome in a homozygote.,2020,10.1111/cge.13730,https://pubmed.ncbi.nlm.nih.gov/32112393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,27555360,Noncoding RNA-regulated gain-of-function of STOX2 in Finnish pre-eclamptic families.,2016,10.1038/srep32129,https://pubmed.ncbi.nlm.nih.gov/27555360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,25143393,Susceptibility allele-specific loss of miR-1324-mediated silencing of the INO80B chromatin-assembly complex gene in pre-eclampsia.,2015,10.1093/hmg/ddu423,https://pubmed.ncbi.nlm.nih.gov/25143393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,31562690,Genome-wide DNA methylation and transcriptome and proteome changes in Mycobacterium tuberculosis with para-aminosalicylic acid resistance.,2020,10.1111/cbdd.13625,https://pubmed.ncbi.nlm.nih.gov/31562690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,27641337,INO80 is required for oncogenic transcription and tumor growth in non-small cell lung cancer.,2017,10.1038/onc.2016.311,https://pubmed.ncbi.nlm.nih.gov/27641337/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,32123834,A novel mutation alters the stability of PapA2 resulting in the complete abrogation of sulfolipids in clinical mycobacterial strains.,2019,10.1096/fba.2018-00039,https://pubmed.ncbi.nlm.nih.gov/32123834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,17259623,Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis.,2007,10.1099/mic.0.2006/003103-0,https://pubmed.ncbi.nlm.nih.gov/17259623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,22208759,Analysis of the toxicogenomic effects of exposure to persistent organic pollutants (POPs) in Slovakian girls: correlations between gene expression and disease risk.,2012,10.1016/j.envint.2011.09.003,https://pubmed.ncbi.nlm.nih.gov/22208759/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,17592143,PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1.,2007,10.1073/pnas.0611649104,https://pubmed.ncbi.nlm.nih.gov/17592143/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,12734547,A new locus for postaxial polydactyly type A/B on chromosome 7q21-q34.,2003,10.1038/sj.ejhg.5200982,https://pubmed.ncbi.nlm.nih.gov/12734547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INO80B,ENSG00000115274,Unsafe,10463389,Urinary antigens as markers of papillary toxicity. II: Application of monoclonal antibodies for the determination of papillary antigens in rat urine.,1999,10.1007/s002040050612,https://pubmed.ncbi.nlm.nih.gov/10463389/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,42899007,INSL3: an informative testis biomarker for assessing the HPG axis in men.,2026,10.3389/fendo.2026.1911172,https://pubmed.ncbi.nlm.nih.gov/42899007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,41921126,Mapping of sex hormones in the testicular vein of healthy men.,2026,10.1210/clinem/dgag070,https://pubmed.ncbi.nlm.nih.gov/41921126/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,42633751,Impact of chemotherapy received prior to testicular tissue cryopreservation on somatic cells from prepubertal to postpubertal males.,2026,10.1093/humrep/deag135,https://pubmed.ncbi.nlm.nih.gov/42633751/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,42440452,The EV-mitochondrial outsourcing network as a therapeutic target for age-related testosterone deficiency: from network collapse to clinical intervention.,2026,10.3389/fendo.2026.1866059,https://pubmed.ncbi.nlm.nih.gov/42440452/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,42850073,Genetic ablation of the adult Leydig cell lineage reveals stem Leydig cells and a peritubular regenerative niche in mice.,2026,10.1210/endocr/bqag113,https://pubmed.ncbi.nlm.nih.gov/42850073/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,40937417,Insulin-like peptide 3 is not a biomarker for pancreatic ductal adenocarcinoma.,2025,10.3389/fendo.2025.1625906,https://pubmed.ncbi.nlm.nih.gov/40937417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,40794697,Revealing the endocrine landscape of INSL3/RXFP2 signaling in hamster.,2025,10.1371/journal.pone.0329696,https://pubmed.ncbi.nlm.nih.gov/40794697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,41978234,"The impact of breast milk relaxin 2, oxytocin, and insulin-like peptide 3 on neonatal growth parameters in early life.",2026,10.1002/jpn3.70438,https://pubmed.ncbi.nlm.nih.gov/41978234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,42565951,INSL3 Preserves Male Reproductive Function Under Inflammatory and Glucocorticoid Stress in Rats.,2026,10.1007/s43032-026-02164-x,https://pubmed.ncbi.nlm.nih.gov/42565951/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,42450625,Trimethylamine N-Oxide and Impaired Spermatogenesis in the Gut-Testis Axis: A Focused Review of Current Evidence.,2026,10.3390/biology15131078,https://pubmed.ncbi.nlm.nih.gov/42450625/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,41219539,Evolutionary relaxation and functional change of INSL3 and RXFP2 may underlie natural cryptorchidism in mammals.,2025,10.1038/s44319-025-00636-w,https://pubmed.ncbi.nlm.nih.gov/41219539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,42588047,Childhood Vitamin D Status and Circulating Insulin-like Peptide 3 as a Marker of Leydig Cell Functional Capacity in Young Adulthood: Findings from the Avon Longitudinal Study of Parents and Children.,2026,10.3390/nu18152426,https://pubmed.ncbi.nlm.nih.gov/42588047/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,42882953,Molecular Mechanisms Underlying α-Linolenic Acid-Enhanced Reproductive Performance in Male Blue Foxes.,2026,10.3390/ani16192984,https://pubmed.ncbi.nlm.nih.gov/42882953/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,41902764,Association between COVID-19 status and Leydig cell functional capacity among men in hospitalized cohorts.,2026,10.1080/13685538.2026.2650000,https://pubmed.ncbi.nlm.nih.gov/41902764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,42299320,Transient gonadotropin suppression by exogenous testosterone decreases INSL3 in early puberty in boys with constitutional delay of growth and puberty.,2026,10.1210/jendso/bvag123,https://pubmed.ncbi.nlm.nih.gov/42299320/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,42495719,A discovery protein panel for brain predicted age discordance using MRI in neurologically healthy individuals.,2026,10.3389/fcell.2026.1833866,https://pubmed.ncbi.nlm.nih.gov/42495719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,41117225,INSL3 Expression in Leydig Cells is a Biomarker for Immunocastration in Boars: Transcriptional Evidence.,2026,10.1111/andr.70136,https://pubmed.ncbi.nlm.nih.gov/41117225/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,41038403,Trem2-dependent Insl3 regulation via Dap12-Syk-PI3K pathway: A new pathogenic mechanism in cryptorchidism.,2025,10.1016/j.ygeno.2025.111120,https://pubmed.ncbi.nlm.nih.gov/41038403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,38791457,Expression of Insl3 Protein in Adult Danio rerio.,2024,10.3390/ijms25105419,https://pubmed.ncbi.nlm.nih.gov/38791457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,40317716,"Effects of &lt;i&gt;INSL3&lt;/i&gt; and &lt;i&gt;WNT2B&lt;/i&gt; gene polymorphisms on seasonal reproductive traits of Xinjiang Qira black sheep, Kazakh sheep and Duolang sheep.",2025,10.1080/10495398.2025.2498677,https://pubmed.ncbi.nlm.nih.gov/40317716/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,42422432,Klinefelter syndrome beyond hypogonadism: multisystem manifestations and a framework for clinical surveillance.,2026,10.3389/fendo.2026.1848181,https://pubmed.ncbi.nlm.nih.gov/42422432/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,42735478,Tetrachlorobisphenol A inhibits steroidogenesis in pubertal rat Leydig cells through disruption of copper homeostasis.,2026,10.1016/j.ecoenv.2026.120801,https://pubmed.ncbi.nlm.nih.gov/42735478/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,41086699,Myclobutanil-induced testis damage and apoptotic germ cell death through ER stress and autophagy in mouse testes.,2025,10.1016/j.ecoenv.2025.119213,https://pubmed.ncbi.nlm.nih.gov/41086699/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,42107477,Nano-selenium attenuates cadmium-induced ER-phagy through inhibition of TFEB nuclear translocation and FAM134B downregulation.,2026,10.1016/j.freeradbiomed.2026.05.011,https://pubmed.ncbi.nlm.nih.gov/42107477/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,41980619,PINK1-PARKIN-dependent mitophagy links diphenyltin exposure to steroidogenic collapse in Rat Leydig Cells during puberty.,2026,10.1016/j.cbi.2026.112081,https://pubmed.ncbi.nlm.nih.gov/41980619/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,37830594,New JAK3-INSL3 Fusion Transcript-An Oncogenic Event in Cutaneous T-Cell Lymphoma.,2023,10.3390/cells12192381,https://pubmed.ncbi.nlm.nih.gov/37830594/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,39765742,Acephate Exposure Induces Transgenerational Ovarian Developmental Toxicity by Altering the Expression of Follicular Growth Markers in Female Rats.,2024,10.3390/biology13121075,https://pubmed.ncbi.nlm.nih.gov/39765742/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,39222519,"Biallelic RXFP2 variants lead to congenital bilateral cryptorchidism and male infertility, supporting a role of RXFP2 in spermatogenesis.",2024,10.1093/humrep/deae195,https://pubmed.ncbi.nlm.nih.gov/39222519/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,41710979,Structure-Activity Relationship Studies toward the Optimization of First-In-Class Selective Small Molecule Agonists of the GPCR Relaxin/Insulin-like Family Peptide Receptor 2.,2026,10.1021/acs.jmedchem.5c03387,https://pubmed.ncbi.nlm.nih.gov/41710979/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,37208861,Bi-allelic variants in INSL3 and RXFP2 cause bilateral cryptorchidism and male infertility.,2023,10.1093/humrep/dead105,https://pubmed.ncbi.nlm.nih.gov/37208861/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,37235781,"Serum Insulin-like Factor 3, Testosterone, and LH in Experimental and Therapeutic Testicular Suppression.",2023,10.1210/clinem/dgad291,https://pubmed.ncbi.nlm.nih.gov/37235781/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,40417115,Immune inflammatory regulation in Anti-NMDAR encephalitis: insights from transcriptome analysis.,2025,10.3389/fneur.2025.1568274,https://pubmed.ncbi.nlm.nih.gov/40417115/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL3,ENSG00000248099,Unsafe,7852540,The human Leydig insulin-like (hLEY I-L) gene is expressed in the corpus luteum and trophoblast.,1995,10.1210/jcem.80.2.7852540,https://pubmed.ncbi.nlm.nih.gov/7852540/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,41489901,DNA-damage dependent isoform switching modulates RIF1 DNA repair complex assembly and phase separation.,2025,10.1016/j.jbc.2025.110857,https://pubmed.ncbi.nlm.nih.gov/41489901/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,40806439,Dysregulated Alternative Splicing in Breast Cancer Subtypes of RIF1 and Other Transcripts.,2025,10.3390/ijms26157308,https://pubmed.ncbi.nlm.nih.gov/40806439/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,42274628,Deciphering the Pleiotropic Role of &lt;i&gt;ARID1a&lt;/i&gt; and &lt;i&gt;RIF1&lt;/i&gt; in Endometrioid Ovarian Cancer.,2026,10.3390/cells15111036,https://pubmed.ncbi.nlm.nih.gov/42274628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,41417274,A busy BOD1-y: the diverse functions of an intracellular signaling regulatory protein family.,2025,10.1042/bst20253107,https://pubmed.ncbi.nlm.nih.gov/41417274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,41542172,Regulatory interplay of cyclin D1 and INSM1 in suppressing INSL6 expression: Implications for breast cancer biology.,2025,10.1016/j.bbrep.2025.102250,https://pubmed.ncbi.nlm.nih.gov/41542172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,40595496,The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress.,2025,10.1038/s41467-025-60817-y,https://pubmed.ncbi.nlm.nih.gov/40595496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,42014854,Chromosome fusion enhances dependency on Rif1 for entanglement resolution during meiosis in S. pombe.,2026,10.1038/s42003-026-10093-3,https://pubmed.ncbi.nlm.nih.gov/42014854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,41285797,53BP1-RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes.,2025,10.1038/s41467-025-65329-3,https://pubmed.ncbi.nlm.nih.gov/41285797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,41168175,Discovery of obesity genes through cross-ancestry analysis.,2025,10.1038/s41467-025-64933-7,https://pubmed.ncbi.nlm.nih.gov/41168175/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,40262611,RIF1 controls replication timing in early mouse embryos independently of lamina-associated nuclear organization.,2025,10.1016/j.devcel.2025.03.016,https://pubmed.ncbi.nlm.nih.gov/40262611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,41595533,Gene Expression-Based Colorectal Cancer Prediction Using Machine Learning and SHAP Analysis.,2026,10.3390/genes17010114,https://pubmed.ncbi.nlm.nih.gov/41595533/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,41881336,YTHDF3 facilitates DNA damage response by recognizing METTL3-mediated m&lt;sup&gt;6&lt;/sup&gt;A modification to promote chemotherapy resistance in glioblastoma.,2026,10.1016/j.canlet.2026.218445,https://pubmed.ncbi.nlm.nih.gov/41881336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,39824820,RIF1 integrates DNA repair and transcriptional requirements during the establishment of humoral immune responses.,2025,10.1038/s41467-025-56166-5,https://pubmed.ncbi.nlm.nih.gov/39824820/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,41243969,GSK3B directs DNA repair choice and determines tumor response to PARP1 inhibition independent of BRCA1.,2025,10.1172/jci189956,https://pubmed.ncbi.nlm.nih.gov/41243969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,42406631,CDW19S coordinates phasic end processing via distinct enzymatic activities.,2026,10.1093/nar/gkag681,https://pubmed.ncbi.nlm.nih.gov/42406631/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,41317429,"Germline lung cancer SNPs dysregulate known (LATS1) and novel (ADCY2) oncogenes through distal, spatially-constrained eQTLs.",2026,10.1016/j.cancergen.2025.11.004,https://pubmed.ncbi.nlm.nih.gov/41317429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,41759527,Shugoshin 2A stabilizes heterochromatin complexes to suppress the 2-cell-like state in embryonic stem cells.,2026,10.1016/j.stemcr.2026.102824,https://pubmed.ncbi.nlm.nih.gov/41759527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,40117291,DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair.,2025,10.1016/j.celrep.2025.115452,https://pubmed.ncbi.nlm.nih.gov/40117291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,41188790,Cross-tissue transcriptome-wide association studies identify genetic susceptibility genes for prostate cancer.,2025,10.1186/s12885-025-14827-0,https://pubmed.ncbi.nlm.nih.gov/41188790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,42072652,NANOG Proximity Proteomics Maps Neighborhood Hubs Linked to Mesenchymal Stem Cell Stemness and Chromatin Control.,2026,10.3390/biom16040531,https://pubmed.ncbi.nlm.nih.gov/42072652/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,41243967,GSK3β guides chromosomal repair pathway selection to support BRCA1-independent PARP inhibitor sensitivity.,2025,10.1172/jci197910,https://pubmed.ncbi.nlm.nih.gov/41243967/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,42172328,53BP1 orchestrates sequence feature of RAG targets to balance DNA repair outcomes during V(D)J recombination.,2026,10.1126/sciadv.aec2231,https://pubmed.ncbi.nlm.nih.gov/42172328/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,36798786,Myocardial Infarction-Induced INSL6 Decrease Contributes to Breast Cancer Progression.,2023,10.1155/2023/8702914,https://pubmed.ncbi.nlm.nih.gov/36798786/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,40121465,Tubercidin enhances apoptosis in serum-starved and hypoxic mouse cardiomyocytes by inducing nuclear speckle condensation.,2025,10.1186/s12872-025-04661-4,https://pubmed.ncbi.nlm.nih.gov/40121465/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,39227718,Shieldin and CST co-orchestrate DNA polymerase-dependent tailed-end joining reactions independently of 53BP1-governed repair pathway choice.,2025,10.1038/s41594-024-01381-9,https://pubmed.ncbi.nlm.nih.gov/39227718/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,40178294,CST Is Epistatic With Shieldin to Limit DNA Double-Strand Break End Resection and Promote Repair During Igh Class Switch Recombination.,2025,10.1002/eji.202451585,https://pubmed.ncbi.nlm.nih.gov/40178294/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,37306046,An AlphaFold2 map of the 53BP1 pathway identifies a direct SHLD3-RIF1 interaction critical for shieldin activity.,2023,10.15252/embr.202356834,https://pubmed.ncbi.nlm.nih.gov/37306046/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,36971904,Rif1 Regulates Self-Renewal and Impedes Mesendodermal Differentiation of Mouse Embryonic Stem Cells.,2023,10.1007/s12015-023-10525-1,https://pubmed.ncbi.nlm.nih.gov/36971904/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,40606259,Comparison of Telomere Structure in Eukaryotes.,2024,10.32592/ari.2024.79.6.1365,https://pubmed.ncbi.nlm.nih.gov/40606259/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,37866880,Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7.,2024,10.1002/1878-0261.13537,https://pubmed.ncbi.nlm.nih.gov/37866880/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,35216668,RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1.,2022,10.1016/j.molcel.2022.01.025,https://pubmed.ncbi.nlm.nih.gov/35216668/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,35838349,A non-transcriptional function of Yap regulates the DNA replication program in Xenopus laevis.,2022,10.7554/elife.75741,https://pubmed.ncbi.nlm.nih.gov/35838349/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,38244928,"Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer.",2024,10.1016/j.annonc.2024.01.003,https://pubmed.ncbi.nlm.nih.gov/38244928/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,39538416,Molecular characterization of human HSPCs with different cell fates in vivo using single-cell transcriptome analysis and lentiviral barcoding technology.,2024,10.1002/ctm2.70085,https://pubmed.ncbi.nlm.nih.gov/39538416/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,39117746,Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks.,2024,10.1038/s41598-024-68926-2,https://pubmed.ncbi.nlm.nih.gov/39117746/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSL6,ENSG00000120210,Unsafe,35177609,RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity.,2022,10.1038/s41467-022-28588-y,https://pubmed.ncbi.nlm.nih.gov/35177609/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,38132452,A Comparative Kidney Transcriptome Analysis of Bicarbonate-Loaded insrr-Null Mice.,2023,10.3390/cimb45120606,https://pubmed.ncbi.nlm.nih.gov/38132452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,42354980,Trimethylamine N-Oxide Derived from a High-Protein Diet Induces Insulin Resistance in Pregnant Mice via Gut Microbiota Remodeling.,2026,10.3390/microorganisms14061356,https://pubmed.ncbi.nlm.nih.gov/42354980/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,39415254,Illuminating the dark kinome: utilizing multiplex peptide activity arrays to functionally annotate understudied kinases.,2024,10.1186/s12964-024-01868-4,https://pubmed.ncbi.nlm.nih.gov/39415254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,36038798,Changes in the Expression of the gapdh Gene in the Organs of insrr Knockout Mice.,2022,10.1134/s0012496622040056,https://pubmed.ncbi.nlm.nih.gov/36038798/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,38984127,Multi-tissue transcriptome-wide association study identifies novel candidate susceptibility genes for cataract.,2024,10.3389/fopht.2024.1362350,https://pubmed.ncbi.nlm.nih.gov/38984127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,37099121,Identification of INSRR as an immune-related gene in the tumor microenvironment of glioblastoma by integrated bioinformatics analysis.,2023,10.1007/s12032-023-02023-8,https://pubmed.ncbi.nlm.nih.gov/37099121/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,39932986,Comparative genomic profiling of SLC26A4-expressing cells in the inner ear and other organs.,2025,10.1371/journal.pone.0318972,https://pubmed.ncbi.nlm.nih.gov/39932986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,40572217,High Protein Diet Contributes to Insulin Resistance in Mice via Shaping Gut Microbiota.,2025,10.3390/microorganisms13061329,https://pubmed.ncbi.nlm.nih.gov/40572217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,36012515,Insulin Receptor-Related Receptor Regulates the Rate of Early Development in &lt;i&gt;Xenopus laevis&lt;/i&gt;.,2022,10.3390/ijms23169250,https://pubmed.ncbi.nlm.nih.gov/36012515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,37168445,Stem Cell-Associated Signatures Help to Predict Diagnosis and Prognosis in Ovarian Serous Cystadenocarcinoma.,2023,10.1155/2023/4500561,https://pubmed.ncbi.nlm.nih.gov/37168445/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,36681680,Epigenomic charting and functional annotation of risk loci in renal cell carcinoma.,2023,10.1038/s41467-023-35833-5,https://pubmed.ncbi.nlm.nih.gov/36681680/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,39529088,"Identification of novel variants and candidate genes in women with 46,XX complete gonadal dysgenesis.",2024,10.1186/s12958-024-01309-4,https://pubmed.ncbi.nlm.nih.gov/39529088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,34196487,Candidate l-methionine target piRNA regulatory networks analysis response to cocaine-conditioned place preference in mice.,2021,10.1002/brb3.2272,https://pubmed.ncbi.nlm.nih.gov/34196487/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,30386171,Early Life Stress and Epigenetics in Late-onset Alzheimer's Dementia: A Systematic Review.,2018,10.2174/1389202919666171229145156,https://pubmed.ncbi.nlm.nih.gov/30386171/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,34002209,The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors.,2021,10.1042/bcj20210144,https://pubmed.ncbi.nlm.nih.gov/34002209/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,29992036,Analysis of protein-protein interaction network based on transcriptome profiling of ovine granulosa cells identifies candidate genes in cyclic recruitment of ovarian follicles.,2018,10.1186/s40781-018-0171-y,https://pubmed.ncbi.nlm.nih.gov/29992036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,26929985,Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer.,2016,10.1080/15592294.2016.1154246,https://pubmed.ncbi.nlm.nih.gov/26929985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,33358171,Identification of functional candidate variants and genes for feed efficiency in Holstein and Jersey cattle breeds using RNA-sequencing.,2021,10.3168/jds.2020-18241,https://pubmed.ncbi.nlm.nih.gov/33358171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,16507138,Genome-wide review of transcriptional complexity in mouse protein kinases and phosphatases.,2006,10.1186/gb-2006-7-1-r5,https://pubmed.ncbi.nlm.nih.gov/16507138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,19956396,Expression profiling of the ovarian surface kinome reveals candidate genes for early neoplastic changes.,2009,10.1593/tlo.09199,https://pubmed.ncbi.nlm.nih.gov/19956396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
INSRR,ENSG00000027644,Unsafe,23234507,Conservation and early expression of zebrafish tyrosine kinases support the utility of zebrafish as a model for tyrosine kinase biology.,2013,10.1089/zeb.2012.0781,https://pubmed.ncbi.nlm.nih.gov/23234507/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,41800303,"The effects of polysaccharides from &lt;i&gt;Inonotus obliquus&lt;/i&gt;, artemisinin, and dihydroartemisinin on the reproductive system of male mice infected with Neospora caninum.",2026,10.3389/fvets.2026.1740054,https://pubmed.ncbi.nlm.nih.gov/41800303/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,38028961,Multi-omics prognostic signatures of IPO11 mRNA expression and clinical outcomes in colorectal cancer using bioinformatics approaches.,2023,10.1007/s13755-023-00259-2,https://pubmed.ncbi.nlm.nih.gov/38028961/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,42360416,"Synthesis and biological evaluation of benzyloxymethyl-substituted imidazo[1,2-a]pyridines as apoptosis-inducing anticancer agents through modulation of BCL-2/Bax signaling and caspase-3 activation.",2026,10.1007/s00210-026-05638-6,https://pubmed.ncbi.nlm.nih.gov/42360416/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,41580526,A single-cell derived spheroid approach to dissect intratumoural heterogeneity in colorectal cancer: cell lines show changes in proteomes and therapeutic response to 5-FU.,2026,10.1007/s00432-025-06418-0,https://pubmed.ncbi.nlm.nih.gov/41580526/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,37195868,Protocol for IPO11 deletion and re-expression in H460 lung cancer cells using CRISPR-Cas9 and plasmid transfection.,2023,10.1016/j.xpro.2023.102317,https://pubmed.ncbi.nlm.nih.gov/37195868/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,36883376,RNA profiling of sEV (small extracellular vesicles)/exosomes reveals biomarkers and vascular endothelial dysplasia with moyamoya disease.,2023,10.1177/0271678x231162184,https://pubmed.ncbi.nlm.nih.gov/36883376/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,38321787,Bioinformatics analysis proposes a possible role for long noncoding RNA MIR17HG in retinoblastoma.,2024,10.1002/cnr2.1933,https://pubmed.ncbi.nlm.nih.gov/38321787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,33571591,The nuclear transporter importin-11 regulates the Wnt/β-catenin pathway and acts as a tumor promoter in glioma.,2021,10.1016/j.ijbiomac.2021.02.043,https://pubmed.ncbi.nlm.nih.gov/33571591/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,35152270,IPO11 regulates the nuclear import of BZW1/2 and is necessary for AML cells and stem cells.,2022,10.1038/s41375-022-01513-4,https://pubmed.ncbi.nlm.nih.gov/35152270/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,32218703,Importin-11 is Essential for Normal Embryonic Development in Mice.,2020,10.7150/ijms.40697,https://pubmed.ncbi.nlm.nih.gov/32218703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,40253697,KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway.,2025,10.1016/j.celrep.2025.115595,https://pubmed.ncbi.nlm.nih.gov/40253697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,33726783,Reproductive injury in male BALB/c mice infected with Neospora caninum.,2021,10.1186/s13071-021-04664-y,https://pubmed.ncbi.nlm.nih.gov/33726783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,39158708,RNA-binding proteins potentially regulate alternative splicing of immune/inflammatory-associated genes during the progression of generalized pustular psoriasis.,2024,10.1007/s00403-024-03283-8,https://pubmed.ncbi.nlm.nih.gov/39158708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,36185355,RPRM negatively regulates ATM levels through its nuclear translocation on irradiation mediated by CDK4/6 and IPO11.,2022,10.1016/j.isci.2022.105115,https://pubmed.ncbi.nlm.nih.gov/36185355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,31881079,IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.,2020,10.1083/jcb.201903017,https://pubmed.ncbi.nlm.nih.gov/31881079/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,36982803,Infection of Trichinella spiralis Affects the Reproductive Capacity of ICR/CD-1 Male Mice by Reducing the Urine Pheromone Contents and Sperm Quality.,2023,10.3390/ijms24065731,https://pubmed.ncbi.nlm.nih.gov/36982803/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,37560480,Marine-derived sea urchin compounds as potential anti-cancer drug candidate against colorectal cancer: In silico and in vitro studies.,2023,10.1016/j.sjbs.2023.103748,https://pubmed.ncbi.nlm.nih.gov/37560480/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,28736931,"Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes.",2018,10.1002/cpt.798,https://pubmed.ncbi.nlm.nih.gov/28736931/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,29602637,"Importin-11 overexpression promotes the migration, invasion, and progression of bladder cancer associated with the deregulation of CDKN1A and THBS1.",2018,10.1016/j.urolonc.2018.03.001,https://pubmed.ncbi.nlm.nih.gov/29602637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IPO11,ENSG00000086200,Unsafe,28193699,Importin-11 keeps PTEN safe from harm.,2017,10.1083/jcb.201612014,https://pubmed.ncbi.nlm.nih.gov/28193699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCD,ENSG00000166578,Unsafe,41602861,"IQ motif family genes in male infertility: pathogenesis, mechanisms, and clinical perspectives.",2025,10.3389/frph.2025.1719934,https://pubmed.ncbi.nlm.nih.gov/41602861/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCD,ENSG00000166578,Unsafe,42274494,A Phenome-Wide Comparative Analysis of Individualized Network Heterogeneity Across Treatment-Response Subphenotypes in Coronary Heart Disease.,2026,10.3390/biology15110843,https://pubmed.ncbi.nlm.nih.gov/42274494/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCD,ENSG00000166578,Unsafe,31039996,"Corrigendum to: IQ motif containing D (IQCD), a new acrosomal protein involved in the acrosome reaction and fertilisation.",2019,10.1071/rd18416_co,https://pubmed.ncbi.nlm.nih.gov/31039996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCD,ENSG00000166578,Unsafe,30712531,"IQ motif containing D (IQCD), a new acrosomal protein involved in the acrosome reaction and fertilisation.",2019,10.1071/rd18416,https://pubmed.ncbi.nlm.nih.gov/30712531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCD,ENSG00000166578,Unsafe,28589840,Characterization of a Sea Urchin IQ Motif Containing Protein D as a Coactivator of Nuclear Receptors.,2017,10.2108/zs160157,https://pubmed.ncbi.nlm.nih.gov/28589840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCD,ENSG00000166578,Unsafe,24804578,Chromosome-centric human proteome project: deciphering proteins associated with glioma and neurodegenerative disorders on chromosome 12.,2014,10.1021/pr500023p,https://pubmed.ncbi.nlm.nih.gov/24804578/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCH,ENSG00000103599,Unsafe,41602861,"IQ motif family genes in male infertility: pathogenesis, mechanisms, and clinical perspectives.",2025,10.3389/frph.2025.1719934,https://pubmed.ncbi.nlm.nih.gov/41602861/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCH,ENSG00000103599,Unsafe,39028117,Deficiency of IQCH causes male infertility in humans and mice.,2024,10.7554/elife.88905,https://pubmed.ncbi.nlm.nih.gov/39028117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCH,ENSG00000103599,Unsafe,36975404,An ancient testis-specific IQ motif-containing H gene regulates specific transcript isoform expression during spermatogenesis.,2023,10.1242/dev.201334,https://pubmed.ncbi.nlm.nih.gov/36975404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCH,ENSG00000103599,Unsafe,37520705,Identification of IQCH as a calmodulin-associated protein required for sperm motility in humans.,2023,10.1016/j.isci.2023.107354,https://pubmed.ncbi.nlm.nih.gov/37520705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCH,ENSG00000103599,Unsafe,42902429,Unraveling circRNAs and ceRNA regulatory networks underlying sex-specific gametogenesis impairment in triploid Pacific oysters (Crassostrea gigas).,2026,10.1186/s13293-026-00958-x,https://pubmed.ncbi.nlm.nih.gov/42902429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCH,ENSG00000103599,Unsafe,41807385,Cell type-specific epigenetic regulatory circuitry of coronary artery disease loci.,2026,10.1038/s41467-026-70216-6,https://pubmed.ncbi.nlm.nih.gov/41807385/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCH,ENSG00000103599,Unsafe,39808350,A comprehensive analysis to reveal the underlying molecular mechanisms of natural killer cell in thyroid carcinoma based on single-cell RNA sequencing data.,2025,10.1007/s12672-025-01779-x,https://pubmed.ncbi.nlm.nih.gov/39808350/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCH,ENSG00000103599,Unsafe,35972306,LncRNA-IQCH-AS1 sensitizes thyroid cancer cells to doxorubicin via modulating the miR-196a-5p/PPP2R1B signalling pathway.,2023,10.1080/1120009x.2022.2082348,https://pubmed.ncbi.nlm.nih.gov/35972306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCH,ENSG00000103599,Unsafe,37898914,A Cuproptosis-Related LncRNA Risk Model for Predicting Prognosis and Immunotherapeutic Efficacy in Patients with Hepatocellular Carcinoma.,2024,10.1007/s10528-023-10539-x,https://pubmed.ncbi.nlm.nih.gov/37898914/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCH,ENSG00000103599,Unsafe,37265662,An exome-wide study of renal operational tolerance.,2022,10.3389/fmed.2022.976248,https://pubmed.ncbi.nlm.nih.gov/37265662/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCH,ENSG00000103599,Unsafe,36510632,Potential serum metabolites and long-chain noncoding RNA biomarkers for endometrial cancer tissue.,2023,10.1111/jog.15494,https://pubmed.ncbi.nlm.nih.gov/36510632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCH,ENSG00000103599,Unsafe,28394258,Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function.,2017,10.1172/jci84840,https://pubmed.ncbi.nlm.nih.gov/28394258/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCH,ENSG00000103599,Unsafe,28089893,Proteomic characterization of the interactions between fish serum proteins and waterborne bacteria reveals the suppression of anti-oxidative defense as a serum-mediated antimicrobial mechanism.,2017,10.1016/j.fsi.2017.01.013,https://pubmed.ncbi.nlm.nih.gov/28089893/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCH,ENSG00000103599,Unsafe,26046917,A Major Gene for Bovine Ovulation Rate.,2015,10.1371/journal.pone.0129025,https://pubmed.ncbi.nlm.nih.gov/26046917/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCH,ENSG00000103599,Unsafe,27132877,Genetic Characteristics of Polycythemia Vera and Essential Thrombocythemia in Korean Patients.,2016,10.1002/jcla.21981,https://pubmed.ncbi.nlm.nih.gov/27132877/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCH,ENSG00000103599,Unsafe,18491143,Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians.,2008,10.1007/s00439-008-0512-x,https://pubmed.ncbi.nlm.nih.gov/18491143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCH,ENSG00000103599,Unsafe,15897968,Identification of a novel testis-specific gene and its potential roles in testis development/spermatogenesis.,2005,10.1111/j.1745-7262.2005.00041.x,https://pubmed.ncbi.nlm.nih.gov/15897968/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCN,ENSG00000130518,Unsafe,41602861,"IQ motif family genes in male infertility: pathogenesis, mechanisms, and clinical perspectives.",2025,10.3389/frph.2025.1719934,https://pubmed.ncbi.nlm.nih.gov/41602861/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCN,ENSG00000130518,Unsafe,40770611,Quantitative Phosphoproteomic Analysis of Testes from &lt;i&gt;Iqcn&lt;/i&gt;-Deficient Mice Highlights the Significance of Calmodulin Signaling in Spermiogenesis.,2025,10.1021/acs.jproteome.5c00440,https://pubmed.ncbi.nlm.nih.gov/40770611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCN,ENSG00000130518,Unsafe,39872118,"Biallelic mutations in IQCN, encoding a novel acroplaxome protein, lead to fertilization failure and male infertility with defects in the acrosome and shaping of the spermatid head in humans and mice.",2023,10.1093/lifemedi/lnac050,https://pubmed.ncbi.nlm.nih.gov/39872118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCN,ENSG00000130518,Unsafe,36321563,IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect.,2022,10.15252/emmm.202216501,https://pubmed.ncbi.nlm.nih.gov/36321563/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCN,ENSG00000130518,Unsafe,39970930,"Beneficial effects of Lactiplantibacillus plantarum BGPKM22 manifest only in interaction with healthy, but not with diseased human bronchial epithelial cells.",2025,10.1163/18762891-bja00060,https://pubmed.ncbi.nlm.nih.gov/39970930/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCN,ENSG00000130518,Unsafe,37184908,Loss-of-function mutations in IQCN cause male infertility in humans and mice owing to total fertilization failure.,2023,10.1093/molehr/gaad018,https://pubmed.ncbi.nlm.nih.gov/37184908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCN,ENSG00000130518,Unsafe,38626700,A prognostic model built on amino acid metabolism patterns in HPV-associated head and neck squamous cell carcinoma.,2024,10.1016/j.archoralbio.2024.105975,https://pubmed.ncbi.nlm.nih.gov/38626700/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCN,ENSG00000130518,Unsafe,38703565,Shared biomarkers and mechanisms in idiopathic pulmonary fibrosis and non-small cell lung cancer.,2024,10.1016/j.intimp.2024.112162,https://pubmed.ncbi.nlm.nih.gov/38703565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCN,ENSG00000130518,Unsafe,22384319,Fine Mapping of a QTL for Fertility on BTA7 and Its Association With a CNV in the Israeli Holsteins.,2011,10.1534/g3.111.000299,https://pubmed.ncbi.nlm.nih.gov/22384319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQCN,ENSG00000130518,Unsafe,37140151,Biallelic variants in IQCN cause sperm flagellar assembly defects and male infertility.,2023,10.1093/humrep/dead079,https://pubmed.ncbi.nlm.nih.gov/37140151/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQUB,ENSG00000164675,Unsafe,41602861,"IQ motif family genes in male infertility: pathogenesis, mechanisms, and clinical perspectives.",2025,10.3389/frph.2025.1719934,https://pubmed.ncbi.nlm.nih.gov/41602861/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQUB,ENSG00000164675,Unsafe,39849482,IQUB mutation induces radial spoke 1 deficiency causing asthenozoospermia with normal sperm morphology in humans and mice.,2025,10.1186/s12964-025-02043-z,https://pubmed.ncbi.nlm.nih.gov/39849482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQUB,ENSG00000164675,Unsafe,42431167,An integrated genetic approach prioritizes closely linked candidate genes underlying an open-field behavior QTL on chicken chromosome 1.,2026,10.1016/j.psj.2026.107390,https://pubmed.ncbi.nlm.nih.gov/42431167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQUB,ENSG00000164675,Unsafe,37732581,[Preparation and application of rabbit polyclonal antibody against mouse IQ and ubiquitin-like domain-containing protein (IQUB)].,2023,,https://pubmed.ncbi.nlm.nih.gov/37732581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQUB,ENSG00000164675,Unsafe,38457249,Mechanisms underlying morphological and functional changes of cilia in fibroblasts derived from patients bearing ARL3&lt;sup&gt;T31A&lt;/sup&gt; and ARL3&lt;sup&gt;T31A/C118F&lt;/sup&gt; mutations.,2024,10.1096/fj.202301906r,https://pubmed.ncbi.nlm.nih.gov/38457249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQUB,ENSG00000164675,Unsafe,36355624,IQUB deficiency causes male infertility by affecting the activity of p-ERK1/2/RSPH3.,2023,10.1093/humrep/deac244,https://pubmed.ncbi.nlm.nih.gov/36355624/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQUB,ENSG00000164675,Unsafe,29968965,Upregulated IQUB promotes cell proliferation and migration via activating Akt/GSK3β/β-catenin signaling pathway in breast cancer.,2018,10.1002/cam4.1568,https://pubmed.ncbi.nlm.nih.gov/29968965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQUB,ENSG00000164675,Unsafe,38617956,Does non-farm employment increase rural households' consumption in western Ethiopia? Empirical evidence from the horo guduru wollega zone.,2024,10.1016/j.heliyon.2024.e26449,https://pubmed.ncbi.nlm.nih.gov/38617956/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQUB,ENSG00000164675,Unsafe,36339449,"Combining bioinformatics, network pharmacology and artificial intelligence to predict the mechanism of celastrol in the treatment of type 2 diabetes.",2022,10.3389/fendo.2022.1030278,https://pubmed.ncbi.nlm.nih.gov/36339449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQUB,ENSG00000164675,Unsafe,37277920,"Transcriptome-wide profile of 1α,25 dihydroxyvitamin D3 in HTR-8/SVneo cells.",2023,10.1111/jog.15685,https://pubmed.ncbi.nlm.nih.gov/37277920/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQUB,ENSG00000164675,Unsafe,26330360,Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma.,2015,10.1038/srep13750,https://pubmed.ncbi.nlm.nih.gov/26330360/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQUB,ENSG00000164675,Unsafe,36276388,"Factors influencing drop-out of households from community based health insurance membership in rural districts of Gurage Zone, Southern Ethiopia: Community based case-control study.",2022,10.3389/fpubh.2022.925309,https://pubmed.ncbi.nlm.nih.gov/36276388/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQUB,ENSG00000164675,Unsafe,24348429,Rare Genomic Variants Link Bipolar Disorder with Anxiety Disorders to CREB-Regulated Intracellular Signaling Pathways.,2013,10.3389/fpsyt.2013.00154,https://pubmed.ncbi.nlm.nih.gov/24348429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQUB,ENSG00000164675,Unsafe,21289087,Functional characterization of putative cilia genes by high-content analysis.,2011,10.1091/mbc.e10-07-0596,https://pubmed.ncbi.nlm.nih.gov/21289087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IQUB,ENSG00000164675,Unsafe,24790831,Participation and significance of self-help groups for social development: exploring the community capacity in Ethiopia.,2014,10.1186/2193-1801-3-189,https://pubmed.ncbi.nlm.nih.gov/24790831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRAK1BP1,ENSG00000146243,Unsafe,42537826,IRAK1BP1 negatively regulated innate immune response via NF-κB signal pathway in blunt snout bream (Megalobrama amblycephala).,2026,10.1016/j.fsi.2026.111611,https://pubmed.ncbi.nlm.nih.gov/42537826/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRAK1BP1,ENSG00000146243,Unsafe,36994215,Identification of IRAK1BP1 as a candidate prognostic factor in lung adenocarcinoma.,2023,10.3389/fonc.2023.1132811,https://pubmed.ncbi.nlm.nih.gov/36994215/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRAK1BP1,ENSG00000146243,Unsafe,40709334,Differential effects of Mediterranean vs. Western diets on coronary atherosclerosis and peripheral artery transcriptomics.,2025,10.3389/fnut.2025.1564741,https://pubmed.ncbi.nlm.nih.gov/40709334/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRAK1BP1,ENSG00000146243,Unsafe,36233348,Biomarkers of Periodontitis and Its Differential DNA Methylation and Gene Expression in Immune Cells: A Systematic Review.,2022,10.3390/ijms231912042,https://pubmed.ncbi.nlm.nih.gov/36233348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRAK1BP1,ENSG00000146243,Unsafe,28883894,Epigenetic regulation of inflammation in localized aggressive periodontitis.,2017,10.1186/s13148-017-0385-8,https://pubmed.ncbi.nlm.nih.gov/28883894/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRAK1BP1,ENSG00000146243,Unsafe,20534545,IRAK1BP1 inhibits inflammation by promoting nuclear translocation of NF-kappaB p50.,2010,10.1073/pnas.1006894107,https://pubmed.ncbi.nlm.nih.gov/20534545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRAK1BP1,ENSG00000146243,Unsafe,22781544,Characterization of interleukin-1 receptor-associated kinase 1 binding protein 1 gene in small abalone Haliotis diversicolor.,2012,10.1016/j.gene.2012.06.038,https://pubmed.ncbi.nlm.nih.gov/22781544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRAK1BP1,ENSG00000146243,Unsafe,25943894,Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA [corrected].,2015,10.1038/srep09887,https://pubmed.ncbi.nlm.nih.gov/25943894/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRAK1BP1,ENSG00000146243,Unsafe,18268037,Forward genetic analysis of Toll-like receptor responses in wild-derived mice reveals a novel antiinflammatory role for IRAK1BP1.,2008,10.1084/jem.20071499,https://pubmed.ncbi.nlm.nih.gov/18268037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRAK1BP1,ENSG00000146243,Unsafe,24097067,Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.,2013,10.1038/ng.2792,https://pubmed.ncbi.nlm.nih.gov/24097067/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRAK1BP1,ENSG00000146243,Unsafe,22759955,Role of IRAK1 on TNF-induced proliferation and NF-ĸB activation in human bone marrow mesenchymal stem cells.,2012,10.1159/000339045,https://pubmed.ncbi.nlm.nih.gov/22759955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IRAK1BP1,ENSG00000146243,Unsafe,24165912,Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.,2013,10.1161/circgenetics.113.000307,https://pubmed.ncbi.nlm.nih.gov/24165912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISM2,ENSG00000100593,Unsafe,42680952,Isthmin-2 is a first-trimester predictor of preeclampsia and fetal growth restriction.,2026,10.1038/s41591-026-04573-6,https://pubmed.ncbi.nlm.nih.gov/42680952/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISM2,ENSG00000100593,Unsafe,41220761,ISM2 as a prognostic biomarker and mediator of immune infiltration in colorectal cancer: evidence from bioinformatics and experimental analysis.,2025,10.21037/jgo-2025-295,https://pubmed.ncbi.nlm.nih.gov/41220761/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISM2,ENSG00000100593,Unsafe,42500561,Integrative Analysis Identified an Eight-Gene Risk Signature Linked to CDK7 and Explored Its Association with HCC Progression via RelA Phosphorylation.,2026,10.32604/or.2026.081711,https://pubmed.ncbi.nlm.nih.gov/42500561/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISM2,ENSG00000100593,Unsafe,33088937,Isthmin 2 is decreased in preeclampsia and highly expressed in choriocarcinoma.,2020,10.1016/j.heliyon.2020.e05096,https://pubmed.ncbi.nlm.nih.gov/33088937/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISM2,ENSG00000100593,Unsafe,36611811,Isthmin-A Multifaceted Protein Family.,2022,10.3390/cells12010017,https://pubmed.ncbi.nlm.nih.gov/36611811/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISM2,ENSG00000100593,Unsafe,37047617,The Labyrinthine Landscape of APP Processing: State of the Art and Possible Novel Soluble APP-Related Molecular Players in Traumatic Brain Injury and Neurodegeneration.,2023,10.3390/ijms24076639,https://pubmed.ncbi.nlm.nih.gov/37047617/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISM2,ENSG00000100593,Unsafe,40837069,Genome-Wide Association Study and Rare Variant Association Studies of Strabismus in the &lt;i&gt;All of Us&lt;/i&gt; Research Program.,2025,10.1016/j.xops.2025.100873,https://pubmed.ncbi.nlm.nih.gov/40837069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISM2,ENSG00000100593,Unsafe,38417673,Comprehensive analysis of a novel subtype of immune microenvironment-derived HPV-infected colorectal cancer.,2024,10.1016/j.micinf.2024.105315,https://pubmed.ncbi.nlm.nih.gov/38417673/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISM2,ENSG00000100593,Unsafe,38956246,ESCCPred: a machine learning model for diagnostic prediction of early esophageal squamous cell carcinoma using autoantibody profiles.,2024,10.1038/s41416-024-02781-w,https://pubmed.ncbi.nlm.nih.gov/38956246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISM2,ENSG00000100593,Unsafe,39194515,Targeting Hypoxia and HIF1α in Triple-Negative Breast Cancer: New Insights from Gene Expression Profiling and Implications for Therapy.,2024,10.3390/biology13080577,https://pubmed.ncbi.nlm.nih.gov/39194515/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISM2,ENSG00000100593,Unsafe,37715129,Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy.,2023,10.1186/s12014-023-09425-w,https://pubmed.ncbi.nlm.nih.gov/37715129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISM2,ENSG00000100593,Unsafe,34177903,A Novel Immune-Related Seventeen-Gene Signature for Predicting Early Stage Lung Squamous Cell Carcinoma Prognosis.,2021,10.3389/fimmu.2021.665407,https://pubmed.ncbi.nlm.nih.gov/34177903/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISM2,ENSG00000100593,Unsafe,21142075,Systematic discovery of ectopic pregnancy serum biomarkers using 3-D protein profiling coupled with label-free quantitation.,2011,10.1021/pr1008866,https://pubmed.ncbi.nlm.nih.gov/21142075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISM2,ENSG00000100593,Unsafe,24324026,Effects of embryo culture media do not persist after implantation: a histological study in mice.,2014,10.1093/humrep/det411,https://pubmed.ncbi.nlm.nih.gov/24324026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISM2,ENSG00000100593,Unsafe,15194193,"TAIL1: an isthmin-like gene, containing type 1 thrombospondin-repeat and AMOP domain, mapped to ARVD1 critical region.",2004,10.1016/j.gene.2004.03.008,https://pubmed.ncbi.nlm.nih.gov/15194193/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISM2,ENSG00000100593,Unsafe,16447100,Pregnancy and delivery after in vitro maturation of naked ICSI-GV oocytes with GH and transfer of a frozen thawed blastocyst: case report.,2006,10.1007/s10815-005-9014-0,https://pubmed.ncbi.nlm.nih.gov/16447100/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISM2,ENSG00000100593,Unsafe,22736328,ART culture conditions change the probability of mouse embryo gestation through defined cellular and molecular responses.,2012,10.1093/humrep/des223,https://pubmed.ncbi.nlm.nih.gov/22736328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,42738349,High Histological Skeletonization as a Measure of Heterogeneity Is Associated with Poor Overall Survival and Death Within 2 Years of Diffuse Large B-Cell Lymphoma.,2026,10.3390/cancers18172828,https://pubmed.ncbi.nlm.nih.gov/42738349/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,42512344,High Histological Entropy Is Correlated with Poor Overall Survival and Death Within the First 2 Years in Diffuse Large B-Cell Lymphoma.,2026,10.3390/cancers18142279,https://pubmed.ncbi.nlm.nih.gov/42512344/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,40609214,Differential expression of lncRNAs and mRNAs in bone marrow-derived mesenchymal stem cells under continuous and intermittent teriparatide treatment.,2025,10.1016/j.biopha.2025.118293,https://pubmed.ncbi.nlm.nih.gov/40609214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,35962262,"Elevated expression of ISY1, APOA-1, SYNE1, MTG1, and MMP10 at HCC initiation: HCC specific protein network involving interactions of key regulators of lipid metabolism, EGFR signaling, MAPK, and splicing pathways.",2023,10.1007/s00709-022-01796-5,https://pubmed.ncbi.nlm.nih.gov/35962262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,40046230,ZNF32 histidine 179 and 183 single-site and double-site mutations promote nuclear speckle formation but differentially regulate the proliferation of breast cancer cells.,2025,10.3389/fcell.2025.1490231,https://pubmed.ncbi.nlm.nih.gov/40046230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,31887540,The splicing component ISY1 regulates APE1 in base excision repair.,2020,10.1016/j.dnarep.2019.102769,https://pubmed.ncbi.nlm.nih.gov/31887540/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,39025375,Lysine lactylation-based insight to understanding the characterization of cervical cancer.,2024,10.1016/j.bbadis.2024.167356,https://pubmed.ncbi.nlm.nih.gov/39025375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,29804889,An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition.,2018,10.1016/j.stem.2018.04.021,https://pubmed.ncbi.nlm.nih.gov/29804889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,33468685,CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs.,2021,10.1128/mbio.02525-20,https://pubmed.ncbi.nlm.nih.gov/33468685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,36628482,Identifying Genetic Susceptibility in Neonates With Hypoxic-Ischemic Encephalopathy: A Retrospective Case Series.,2023,10.1177/08830738221147805,https://pubmed.ncbi.nlm.nih.gov/36628482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,33719345,Identification and Validation of a Novel DNA Damage and DNA Repair Related Genes Based Signature for Colon Cancer Prognosis.,2021,10.3389/fgene.2021.635863,https://pubmed.ncbi.nlm.nih.gov/33719345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,34850936,A distinct complex of PRP19-related and trypanosomatid-specific proteins is required for pre-mRNA splicing in trypanosomes.,2021,10.1093/nar/gkab1152,https://pubmed.ncbi.nlm.nih.gov/34850936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,33978753,A termination-independent role of Rat1 in cotranscriptional splicing.,2021,10.1093/nar/gkab339,https://pubmed.ncbi.nlm.nih.gov/33978753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,33705709,Structural basis for conformational equilibrium of the catalytic spliceosome.,2021,10.1016/j.molcel.2021.02.021,https://pubmed.ncbi.nlm.nih.gov/33705709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,29487104,Prp8 positioning of U5 snRNA is linked to 5' splice site recognition.,2018,10.1261/rna.065458.117,https://pubmed.ncbi.nlm.nih.gov/29487104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,26255770,A Biogenesis Step Upstream of Microprocessor Controls miR-17∼92 Expression.,2015,10.1016/j.cell.2015.07.008,https://pubmed.ncbi.nlm.nih.gov/26255770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,28569192,The Binding Sites of miR-619-5p in the mRNAs of Human and Orthologous Genes.,2017,10.1186/s12864-017-3811-6,https://pubmed.ncbi.nlm.nih.gov/28569192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,29257349,"Competing endogenous RNA network analysis of CD274, IL‑10 and FOXP3 co‑expression in laryngeal squamous cell carcinoma.",2018,10.3892/mmr.2017.8307,https://pubmed.ncbi.nlm.nih.gov/29257349/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,27084940,Tetratricopeptide repeat factor XAB2 mediates the end resection step of homologous recombination.,2016,10.1093/nar/gkw275,https://pubmed.ncbi.nlm.nih.gov/27084940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ISY1,ENSG00000240682,Unsafe,27459055,Cryo-EM structure of the spliceosome immediately after branching.,2016,10.1038/nature19316,https://pubmed.ncbi.nlm.nih.gov/27459055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,42899813,Inter-α-inhibitor heavy chain 4 levels in incident and prevalent patients with primary biliary cholangitis.,2026,10.1080/00365521.2026.2748834,https://pubmed.ncbi.nlm.nih.gov/42899813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,40988056,Long-read sequencing reveals the RNA isoform repertoire of neuropsychiatric risk genes in human brain.,2025,10.1186/s13059-025-03724-1,https://pubmed.ncbi.nlm.nih.gov/40988056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,40404214,Particulate matter-related ITIH4 deficiency is associated with an emphysema phenotype of COPD through JNK-dependent and JNK-independent signalling.,2025,10.1183/13993003.01610-2024,https://pubmed.ncbi.nlm.nih.gov/40404214/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,41805967,Proteomics-based biomarkers of plasma exosomes from patients with acute myocardial infarction.,2026,10.1371/journal.pone.0343804,https://pubmed.ncbi.nlm.nih.gov/41805967/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,41998424,Macrophages with ITIH4 overexpression attenuate inflammatory responses and regulate intestinal epithelial cells.,2026,10.1007/s00011-026-02247-0,https://pubmed.ncbi.nlm.nih.gov/41998424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,42395052,Illustration of the gut-immune-liver axis in early-stage alcohol-related liver disease: role and non-invasive potentiation of biomarkers and peptidomic signatures.,2026,10.1038/s44355-026-00072-0,https://pubmed.ncbi.nlm.nih.gov/42395052/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,42439352,Proteome-Wide Mendelian Randomization Identifies Novel Plasma Protein Targets in Osteoarthritis.,2026,10.2174/0109298673436657260615102240,https://pubmed.ncbi.nlm.nih.gov/42439352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,41134855,Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) in saliva of pigs: evaluation of two commercially available ELISA kits for its measurement and distribution of its main components.,2025,10.1371/journal.pone.0335133,https://pubmed.ncbi.nlm.nih.gov/41134855/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,41735691,Role of ITIH4 in Modulating YAP/TAZ-Mediated Apoptosis of Type II Alveolar Epithelium during Acute Respiratory Distress Syndrome.,2026,10.1007/s11095-026-04038-y,https://pubmed.ncbi.nlm.nih.gov/41735691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,42739747,Composition and Function of Decellularized Human Lung Extracellular Matrix from Congenital Pulmonary Airway Malformation.,2026,10.3390/jcm15176742,https://pubmed.ncbi.nlm.nih.gov/42739747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,41890272,Bioinformatics and machine learning identify ITIH4 and ZC3H13 as novel mRNA biomarkers for major depressive disorder that promote microglial M1 polarization.,2026,10.1007/s10616-026-00923-x,https://pubmed.ncbi.nlm.nih.gov/41890272/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,42019823,Integrative multi-omics implicates a CTSB/ITIH-ECM axis in autism spectrum disorder.,2026,10.1016/j.nbd.2026.107402,https://pubmed.ncbi.nlm.nih.gov/42019823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,40410722,ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota.,2025,10.1186/s10020-025-01270-x,https://pubmed.ncbi.nlm.nih.gov/40410722/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,42038593,Parallel Single-Tissue Summary-Data Mendelian Randomization and Functional Validation Identify the ARRDC1 Promoter SNP rs4494021 as a Genetic Marker Associated with Anxiety Disorders.,2026,10.2147/ndt.s593689,https://pubmed.ncbi.nlm.nih.gov/42038593/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,40608509,The role of ITIH4 in regulating the PI3K/Akt signalling in rheumatoid arthritis.,2025,10.1093/rheumatology/keaf363,https://pubmed.ncbi.nlm.nih.gov/40608509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,42686225,Enrichment Performance Assessment of Extracellular Vesicles Using Different Functionalized Magnetic Materials and Application in Urinary Proteomics of Prostate Cancer.,2026,10.1021/acsami.6c12149,https://pubmed.ncbi.nlm.nih.gov/42686225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,39323962,Plasma alpha-trypsin inhibitor heavy chain 4 as an age-specific biomarker in the diagnosis and treatment of major depressive disorder.,2024,10.3389/fpsyt.2024.1449202,https://pubmed.ncbi.nlm.nih.gov/39323962/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,41102784,Integrating single-cell RNA sequencing and Mendelian randomization analysis to identify potential drug targets for dilated cardiomyopathy.,2025,10.1186/s41065-025-00539-9,https://pubmed.ncbi.nlm.nih.gov/41102784/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,41998640,Integrated serum proteomic and liver genomic analyses identify molecular signatures associated with metabolic dysfunction-associated steatotic liver disease: a multi-cohort study.,2026,10.1186/s12916-026-04834-8,https://pubmed.ncbi.nlm.nih.gov/41998640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,40437524,ITIH4 attenuates acute lung injury by Fe-containing particulate matter in mice via Hippo pathway in type II alveolar epithelial cells.,2025,10.1186/s12931-025-03256-z,https://pubmed.ncbi.nlm.nih.gov/40437524/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,40911226,One of These Things is Not Like the Other: Parents' Experience of Family-Focused Substance Use Treatment.,2025,10.1007/s10488-025-01471-w,https://pubmed.ncbi.nlm.nih.gov/40911226/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,41644158,"Doravirine versus dolutegravir-based regimen in antiretroviral treatment-naive people living with HIV-1 (ANRS0392s ELDORADO): protocol for an international, open-label, randomised, non-inferiority, phase III trial.",2026,10.1136/bmjopen-2025-110560,https://pubmed.ncbi.nlm.nih.gov/41644158/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,39454824,Serum proteomic analysis identified ITIH4 as a potential novel biomarker for feline infectious peritonitis.,2025,10.1016/j.jprot.2024.105338,https://pubmed.ncbi.nlm.nih.gov/39454824/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,39311312,ITIH4 in Rheumatoid Arthritis Pathogenesis: Network Pharmacology and Molecular Docking Analysis Identify CXCR4 as a Potential Receptor.,2024,10.3390/pathophysiology31030038,https://pubmed.ncbi.nlm.nih.gov/39311312/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,40820459,A Comprehensive Analysis of the ITIH Family Across Multiple Cancer Types and an Initial Investigation of ITIH1 in Gastric Cancer.,2026,10.2174/0109298673375809250730142009,https://pubmed.ncbi.nlm.nih.gov/40820459/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,39040328,"Discovery, identification and mechanism of chemosensitivity-relate biomarker inter-α-trypsin inhibitor heavy chain 4 in metastatic colorectal cancer.",2024,10.1016/j.heliyon.2024.e33571,https://pubmed.ncbi.nlm.nih.gov/39040328/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,42018468,Correlates of Serum Concentrations of Biomarkers Relevant to Ovarian Cancer Screening.,2026,10.1093/jalm/jfag044,https://pubmed.ncbi.nlm.nih.gov/42018468/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,38216619,Identification of an inflammation-related risk signature for prognosis and immunotherapeutic response prediction in bladder cancer.,2024,10.1038/s41598-024-51158-9,https://pubmed.ncbi.nlm.nih.gov/38216619/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,38480609,Effects of occupational exposure to metal fume PM&lt;sub&gt;2.5&lt;/sub&gt; on lung function and biomarkers among shipyard workers: a 3-year prospective cohort study.,2024,10.1007/s00420-024-02055-1,https://pubmed.ncbi.nlm.nih.gov/38480609/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,39632834,Dynamics of the blood plasma proteome during hyperacute HIV-1 infection.,2024,10.1038/s41467-024-54848-0,https://pubmed.ncbi.nlm.nih.gov/39632834/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,37483617,Network proteomic analysis identifies inter-alpha-trypsin inhibitor heavy chain 4 during early human Achilles tendon healing as a prognostic biomarker of good long-term outcomes.,2023,10.3389/fimmu.2023.1191536,https://pubmed.ncbi.nlm.nih.gov/37483617/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,38637796,"Sparassis latifolia and exercise training as complementary medicine mitigated the 5-fluorouracil potent side effects in mice with colorectal cancer: bioinformatics approaches, novel monitoring pathological metrics, screening signatures, and innovative management tactic.",2024,10.1186/s12935-024-03328-y,https://pubmed.ncbi.nlm.nih.gov/38637796/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,41983062,"Pomegranate-derived nanovesicles as therapeutic agents for acute pancreatitis in a murine model: anti-inflammatory, antioxidant, and endocrine-protective properties.",2026,10.20517/evcna.2025.145,https://pubmed.ncbi.nlm.nih.gov/41983062/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,40659816,"Properdin, transcortin and HGFAC are novel plasma biomarkers in canine chronic inflammatory enteropathies from active disease to remission.",2025,10.1038/s41598-025-11474-0,https://pubmed.ncbi.nlm.nih.gov/40659816/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,7805892,"cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein.",1995,10.1016/0014-5793(94)01364-7,https://pubmed.ncbi.nlm.nih.gov/7805892/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITIH4,ENSG00000055955,Unsafe,7775381,"Cloning and characterization of cDNA for inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP), a novel human plasma glycoprotein.",1995,10.1093/oxfordjournals.jbchem.a124701,https://pubmed.ncbi.nlm.nih.gov/7775381/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITPRIPL1,ENSG00000198885,Unsafe,42728269,ITPRIPL1: A tumor immune-associated biomarker with prognostic and therapeutic implications in gastrointestinal cancer.,2026,10.1038/s41598-026-64178-4,https://pubmed.ncbi.nlm.nih.gov/42728269/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITPRIPL1,ENSG00000198885,Unsafe,40792394,Immune Evasion Mechanism Mediated by ITPRIPL1 and Its Prognostic Implications in Glioma.,2025,10.1002/brb3.70762,https://pubmed.ncbi.nlm.nih.gov/40792394/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITPRIPL1,ENSG00000198885,Unsafe,39211744,A comprehensive pan-cancer analysis revealing the role of ITPRIPL1 as a prognostic and immunological biomarker.,2024,10.3389/fmolb.2024.1452290,https://pubmed.ncbi.nlm.nih.gov/39211744/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITPRIPL1,ENSG00000198885,Unsafe,41365494,Integrated Multiomics Analysis and Experimental Validation Identify ITPRIPL1 as an Immunoregulatory and Prognostic Biomarker in Gastric Adenocarcinoma.,2026,10.1111/jgh.70183,https://pubmed.ncbi.nlm.nih.gov/41365494/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITPRIPL1,ENSG00000198885,Unsafe,42141271,Targeting CD3L1-NRP2 disarms myeloid-driven tumor immune evasion.,2026,10.1038/s44321-026-00451-3,https://pubmed.ncbi.nlm.nih.gov/42141271/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITPRIPL1,ENSG00000198885,Unsafe,38188019,Development of a monoclonal antibody to ITPRIPL1 for immunohistochemical diagnosis of non-small cell lung cancers: accuracy and correlation with CD8+ T cell infiltration.,2023,10.3389/fcell.2023.1297211,https://pubmed.ncbi.nlm.nih.gov/38188019/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITPRIPL1,ENSG00000198885,Unsafe,41298649,CD3L1 expression and its association with the tumor microenvironment in 62 cases of osteosarcoma and Chordoma.,2025,10.1038/s41598-025-25978-2,https://pubmed.ncbi.nlm.nih.gov/41298649/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITPRIPL1,ENSG00000198885,Unsafe,42369204,"Hypoxia-Associated Molecular Subtypes Reveal Immune Checkpoint, Ferroptosis, and m6A Regulatory Heterogeneity in Pediatric Vasculitis.",2026,10.1155/humu/7451086,https://pubmed.ncbi.nlm.nih.gov/42369204/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITPRIPL1,ENSG00000198885,Unsafe,38614099,ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion.,2024,10.1016/j.cell.2024.03.019,https://pubmed.ncbi.nlm.nih.gov/38614099/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITPRIPL1,ENSG00000198885,Unsafe,39202766,Methylated DNA Markers in Voided Urine for the Identification of Clinically Significant Prostate Cancer.,2024,10.3390/life14081024,https://pubmed.ncbi.nlm.nih.gov/39202766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITPRIPL1,ENSG00000198885,Unsafe,40921428,"AARS1 Implicates Malignancy and Immune Infiltration in Head and Neck Squamous Cell Carcinoma, Serving as a Prognostic Predictor.",2025,10.1111/jop.70058,https://pubmed.ncbi.nlm.nih.gov/40921428/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITPRIPL1,ENSG00000198885,Unsafe,37628841,Methylation Profile of Small Breast Cancer Tumors Evaluated by Modified MS-HRM.,2023,10.3390/ijms241612660,https://pubmed.ncbi.nlm.nih.gov/37628841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITPRIPL1,ENSG00000198885,Unsafe,33803633,"Automatic Detection of the Circulating Cell-Free Methylated DNA Pattern of GCM2, ITPRIPL1 and CCDC181 for Detection of Early Breast Cancer and Surgical Treatment Response.",2021,10.3390/cancers13061375,https://pubmed.ncbi.nlm.nih.gov/33803633/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITPRIPL1,ENSG00000198885,Unsafe,41234821,Bulk and single-cell transcriptomics of stomach adenocarcinoma provide prognostic insights via the application of a novel gene signature associated with manganese metabolism.,2025,10.21037/tcr-2025-1826,https://pubmed.ncbi.nlm.nih.gov/41234821/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITPRIPL1,ENSG00000198885,Unsafe,33550903,A Novel 10-Gene Signature Predicts Poor Prognosis in Low Grade Glioma.,2021,10.1177/1533033821992084,https://pubmed.ncbi.nlm.nih.gov/33550903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ITPRIPL1,ENSG00000198885,Unsafe,31558162,Methylation and transcriptome analysis reveal lung adenocarcinoma-specific diagnostic biomarkers.,2019,10.1186/s12967-019-2068-z,https://pubmed.ncbi.nlm.nih.gov/31558162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO4,ENSG00000099840,Unsafe,42829918,WFS1 Deficiency Impairs PIAS4-Associated SUMOylation and Increases Ubiquitin-Mediated Spermatogenesis-Related Protein Degradation Leading to Testicular Male Infertility.,2026,10.1002/advs.78060,https://pubmed.ncbi.nlm.nih.gov/42829918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO4,ENSG00000099840,Unsafe,40760720,Uncovering the Role of IZUMO Family Members in Human Fertilization.,2025,10.1002/mrd.70040,https://pubmed.ncbi.nlm.nih.gov/40760720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO4,ENSG00000099840,Unsafe,40572022,Mouse genome engineering uncovers 18 genes dispensable for male reproduction.,2026,10.1111/andr.70088,https://pubmed.ncbi.nlm.nih.gov/40572022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO4,ENSG00000099840,Unsafe,42187729,Identification of Reproductive Trait-Associated Loci and Candidate Genes in Commercial Pigs via 50K SNP Genotyping and Genome-Wide Association Study.,2026,10.3390/biology15100766,https://pubmed.ncbi.nlm.nih.gov/42187729/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO4,ENSG00000099840,Unsafe,42518043,"Cross-species comparative transcriptomic analysis of spermatozoa reveals species-specific regulatory networks linked to fertilization-associated genes in cattle, sheep and goats.",2026,10.1007/s11427-024-3211-6,https://pubmed.ncbi.nlm.nih.gov/42518043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO4,ENSG00000099840,Unsafe,37046330,New insights into posttranslational modifications of proteins during bull sperm capacitation.,2023,10.1186/s12964-023-01080-w,https://pubmed.ncbi.nlm.nih.gov/37046330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO4,ENSG00000099840,Unsafe,37435199,Identification of key modules and micro RNAs associated with colorectal cancer via a weighted gene co-expression network analysis and competing endogenous RNA network analysis.,2023,10.21037/jgo-23-244,https://pubmed.ncbi.nlm.nih.gov/37435199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO4,ENSG00000099840,Unsafe,39406274,Investigating the effects of COVID-19 on sperm in male smokers: A prospective integrated proteomic and metabolomic study.,2024,10.1016/j.reprotox.2024.108734,https://pubmed.ncbi.nlm.nih.gov/39406274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO4,ENSG00000099840,Unsafe,36685928,Prognostic implication and immunotherapy response prediction of a ubiquitination-related gene signature in breast cancer.,2022,10.3389/fgene.2022.1038207,https://pubmed.ncbi.nlm.nih.gov/36685928/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO4,ENSG00000099840,Unsafe,36714547,High-throughput proteomic characterization of seminal plasma from bulls with contrasting semen quality.,2023,10.1007/s13205-023-03474-6,https://pubmed.ncbi.nlm.nih.gov/36714547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO4,ENSG00000099840,Unsafe,34360666,Bull Sperm Capacitation Is Accompanied by Redox Modifications of Proteins.,2021,10.3390/ijms22157903,https://pubmed.ncbi.nlm.nih.gov/34360666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
IZUMO4,ENSG00000099840,Unsafe,22957301,Positive Selection and the Evolution of izumo Genes in Mammals.,2012,10.1155/2012/958164,https://pubmed.ncbi.nlm.nih.gov/22957301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,42660533,Brain calcification-associated JAM2 pathogenic mutations impair JAM2-JAM3 tight junction structure and the blood-brain barrier integrity.,2026,10.1111/bpa.70139,https://pubmed.ncbi.nlm.nih.gov/42660533/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,42163865,PAX1/JAM3 methylation-a novel biomarker for early detection and accurate management of cervical adenocarcinoma.,2026,10.62347/satu5579,https://pubmed.ncbi.nlm.nih.gov/42163865/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,42830604,Differential diagnostic value of PAX1 and JAM3 methylation for cervical intraepithelial neoplasia between premenopausal and postmenopausal women: a retrospective clinical study in China.,2026,10.1080/07853890.2026.2722566,https://pubmed.ncbi.nlm.nih.gov/42830604/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,42169140,Methylation-based biomarkers from thin-prep cytology test samples for early detection of cervical cancer: application and clinical potential.,2026,10.1186/s13148-026-02154-5,https://pubmed.ncbi.nlm.nih.gov/42169140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,42426866,Preliminary study on PAX1/JAM3 methylation and HPV viral load in CIN3-like squamous cell carcinoma: Are there differences from CIN3 and early invasive carcinoma?,2026,10.1186/s13148-026-02201-1,https://pubmed.ncbi.nlm.nih.gov/42426866/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,41572269,PAX1/JAM3 methylation in cervical exfoliated cells: a robust diagnostic biomarker for cervical high-grade lesions associated with vaginal dysbiosis.,2026,10.1186/s12905-026-04285-6,https://pubmed.ncbi.nlm.nih.gov/41572269/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,40711818,Epigenetic silencing of JAM3 promoted progression in serous ovarian carcinoma through PI3K/AKT pathway.,2025,10.1080/17501911.2025.2535942,https://pubmed.ncbi.nlm.nih.gov/40711818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,42291101,"Comparative evaluation of junctional adhesion molecule 3 and paired box gene 1 methylation, cytology, E6/E7 messenger RNA, and high-risk human papillomavirus testing for detecting precancerous cervical lesions.",2026,10.25259/cytojournal_239_2024,https://pubmed.ncbi.nlm.nih.gov/42291101/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,42428263,Efficacy of 5-aminolevulinic acid photodynamic therapy for the treatment of female lower reproductive tract intraepithelial lesions and its predictive biomarker: DNA methylation.,2026,10.3389/fmed.2026.1828763,https://pubmed.ncbi.nlm.nih.gov/42428263/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,42699011,Diagnostic Accuracy of DNA Methylation Markers for Detecting Cervical Precancer and Cervical Cancer: A Systematic Review and Meta-analysis.,2026,10.22037/aaem.v14i1.3062,https://pubmed.ncbi.nlm.nih.gov/42699011/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,42661176,A combined PAX1/JAM3 methylation and HPV viral load model for exploratory risk stratification of ≥CIN2 among women with positive cervical screening results.,2026,10.1186/s12885-026-16788-4,https://pubmed.ncbi.nlm.nih.gov/42661176/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,41845480,Effectiveness analysis and clinical application potential exploration of combined detection of PAX1/JAM3 gene methylation in early diagnosis of cervical precancerous lesions.,2026,10.1186/s13148-026-02095-z,https://pubmed.ncbi.nlm.nih.gov/41845480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,42351112,"Association of PAX1/JAM3 gene methylation, HR-HPV, and TCT with high-grade cervical lesions in a high-risk cohort: a multinomial logistic regression analysis.",2026,10.1186/s12905-026-04622-9,https://pubmed.ncbi.nlm.nih.gov/42351112/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,41500374,JAM3 orchestrates Mac-1-dependent AKT phosphorylation to facilitate neutrophil extracellular trap-driven meningioma pathogenesis.,2026,10.1016/j.cellsig.2026.112353,https://pubmed.ncbi.nlm.nih.gov/41500374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,42171339,PAX1 and ZNF582 Methylation as a Triage Strategy in Cytologic and hrHPV+ Scrapings in Both Chinese and Dutch Cohorts.,2026,10.1158/1055-9965.epi-26-0015,https://pubmed.ncbi.nlm.nih.gov/42171339/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,39749700,Epigenetic silencing of JAM3 promotes laryngeal squamous cell carcinoma development by inhibiting the Hippo pathway.,2025,10.3892/or.2024.8861,https://pubmed.ncbi.nlm.nih.gov/39749700/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,41935040,Plasma proteome profiling identifies novel biomarkers and predictors for schizophrenia.,2026,10.1038/s41398-026-04017-2,https://pubmed.ncbi.nlm.nih.gov/41935040/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,41239544,Enhanced diagnostic accuracy of high-grade cervical intraepithelial neoplasia in postmenopausal women through PAX1/JAM3 methylation analysis.,2026,10.1002/ijc.70245,https://pubmed.ncbi.nlm.nih.gov/41239544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,39320657,Junctional adhesion molecular 3 (JAM3) is a novel tumor suppressor and improves the prognosis in breast cancer brain metastases via the TGF-β/Smad signal pathway.,2024,10.1007/s11060-024-04797-x,https://pubmed.ncbi.nlm.nih.gov/39320657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,42135963,HPV E6/E7 mRNA vs. HPV DNA in co-testing with ThinPrep cytology for cervical cancer screening: a prospective observational diagnostic accuracy study of methylation biomarkers.,2026,10.3802/jgo.2026.37.e109,https://pubmed.ncbi.nlm.nih.gov/42135963/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,39528979,Cervical cancer screening: efficacy of PAX1 and JAM3 methylation assay in the triage of atypical squamous cell of undetermined significance (ASC-US).,2024,10.1186/s12885-024-13082-z,https://pubmed.ncbi.nlm.nih.gov/39528979/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,38760803,JAM3 promotes cervical cancer metastasis by activating the HIF-1α/VEGFA pathway.,2024,10.1186/s12905-024-03127-7,https://pubmed.ncbi.nlm.nih.gov/38760803/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,40931129,Molecular analysis of lung adenocarcinomas from the SAFIR02-Lung cohort reveals new metastasis-associated copy-number alterations including frequent mutant-specific KRAS-allelic imbalance and identifies CDKN2A homozygous deletions as an independent biomarker of poor prognosis.,2025,10.1038/s41416-025-03183-2,https://pubmed.ncbi.nlm.nih.gov/40931129/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,40646496,Stromal PLAU mediates tumor progression and informs a novel therapeutic target in triple-negative breast cancer.,2025,10.1186/s12935-025-03867-y,https://pubmed.ncbi.nlm.nih.gov/40646496/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,41840107,Genetic basis of immunity in Indian cattle as revealed by comparative analysis of Bos genome.,2026,10.1038/s41598-026-44002-9,https://pubmed.ncbi.nlm.nih.gov/41840107/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,38400838,JAM3: A prognostic biomarker for bladder cancer via epithelial-mesenchymal transition regulation.,2024,10.17305/bb.2024.9979,https://pubmed.ncbi.nlm.nih.gov/38400838/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,39659794,Assessment of PAX1 and JAM3 methylation triage efficacy across HPV genotypes and age groups in high-risk HPV-positive women in China.,2024,10.3389/fonc.2024.1481626,https://pubmed.ncbi.nlm.nih.gov/39659794/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,39726021,Evaluating PAX1/JAM3 methylation for triage in HPV 16/18-infected women.,2024,10.1186/s13148-024-01804-w,https://pubmed.ncbi.nlm.nih.gov/39726021/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,41261613,Prognostic and immune microenvironment of a cancer-associated fibroblast-related genes signature for biochemical recurrence in prostate cancer.,2025,10.1097/md.0000000000045451,https://pubmed.ncbi.nlm.nih.gov/41261613/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,39603822,Triage performance of DNA methylation for women with high-risk human papillomavirus infection.,2025,10.1093/oncolo/oyae324,https://pubmed.ncbi.nlm.nih.gov/39603822/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,38954834,Genetic deletion of JAM-C in preleukemic cells rewires leukemic stem cell gene expression program in AML.,2024,10.1182/bloodadvances.2023011747,https://pubmed.ncbi.nlm.nih.gov/38954834/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,40329965,Comprehensive analysis of lactylation-related gene and immune microenvironment in atrial fibrillation.,2025,10.3389/fcvm.2025.1567310,https://pubmed.ncbi.nlm.nih.gov/40329965/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,20592283,Junctional adhesion molecule-C is a soluble mediator of angiogenesis.,2010,10.4049/jimmunol.1000556,https://pubmed.ncbi.nlm.nih.gov/20592283/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,15994945,Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth.,2005,10.1158/0008-5472.can-04-4012,https://pubmed.ncbi.nlm.nih.gov/15994945/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,15372036,Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C.,2004,10.1038/nature02877,https://pubmed.ncbi.nlm.nih.gov/15372036/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,15194813,JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration.,2004,10.1091/mbc.e04-04-0317,https://pubmed.ncbi.nlm.nih.gov/15194813/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,12208882,The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1.,2002,10.1084/jem.20020267,https://pubmed.ncbi.nlm.nih.gov/12208882/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,11944976,"Narrowing the critical region within 11q24-qter for hypoplastic left heart and identification of a candidate gene, JAM3, expressed during cardiogenesis.",2002,10.1006/geno.2002.6742,https://pubmed.ncbi.nlm.nih.gov/11944976/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JAM3,ENSG00000166086,Unsafe,11590146,Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor.,2001,10.1074/jbc.m105972200,https://pubmed.ncbi.nlm.nih.gov/11590146/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,42095895,Jmjd1c-mediated epigenetic control of autoimmunity and HIT antibody production.,2026,10.1182/blood.2025029593,https://pubmed.ncbi.nlm.nih.gov/42095895/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,42045024,[&lt;i&gt;Jia Wei Qingxin&lt;/i&gt; Lotus Seed Drink improves diabetic kidney disease in mice by regulating the KDM3C/SP1 signaling pathway].,2026,10.12122/j.issn.1673-4254.2026.04.02,https://pubmed.ncbi.nlm.nih.gov/42045024/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,41548765,Endothelial JMJD1C drives pathological ocular neovascularization by activating SREBF2-dependent cholesterol biosynthesis.,2026,10.1016/j.freeradbiomed.2026.01.024,https://pubmed.ncbi.nlm.nih.gov/41548765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,40485981,Enhancer profiling uncovers Jmjd1c as an essential suppressor in neuropathic pain by targeting Socs3.,2025,10.1016/j.gendis.2025.101545,https://pubmed.ncbi.nlm.nih.gov/40485981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,42143165,Exploring dysregulation of cuproptosis-related genes molecular clusters and candidate biomarkers in pterygium.,2026,10.1038/s41598-026-53162-7,https://pubmed.ncbi.nlm.nih.gov/42143165/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,39450904,JMJD1C forms condensate to facilitate a RUNX1-dependent gene expression program shared by multiple types of AML cells.,2025,10.1093/procel/pwae059,https://pubmed.ncbi.nlm.nih.gov/39450904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,42794813,Polymorphic Variant Associated with Sex Hormone-Binding Globulin Level Is a Risk Factor for Preeclampsia.,2026,10.3390/ijms27188387,https://pubmed.ncbi.nlm.nih.gov/42794813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,38926399,Epigenetic roles of KDM3B and KDM3C in tumorigenesis and their therapeutic implications.,2024,10.1038/s41419-024-06850-z,https://pubmed.ncbi.nlm.nih.gov/38926399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,39152304,"BRD4 expression and its regulatory interaction with miR-26a-3p, DLG5-AS1, and JMJD1C-AS1 lncRNAs in gastric cancer progression.",2024,10.1007/s12672-024-01230-7,https://pubmed.ncbi.nlm.nih.gov/39152304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,41190981,Epigenetic repression of hepatocyte FoxO1 disrupts local immune homeostasis and promotes liver inflammation.,2026,10.1097/hep.0000000000001590,https://pubmed.ncbi.nlm.nih.gov/41190981/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,42257465,Integrative multi-omics analysis-based Mendelian randomization identifies association of DNA repair-related genes with oral cancer.,2026,10.1177/18758592261455209,https://pubmed.ncbi.nlm.nih.gov/42257465/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,42585843,Targeted sequencing reveals a distinct genetic alteration landscape in oral multiple primary squamous cell carcinomas.,2026,10.1016/j.archoralbio.2026.106716,https://pubmed.ncbi.nlm.nih.gov/42585843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,38575196,Machine learning identifies novel coagulation genes as diagnostic and immunological biomarkers in ischemic stroke.,2024,10.18632/aging.205706,https://pubmed.ncbi.nlm.nih.gov/38575196/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,39553230,Comprehensive analysis of the oncogenic potential of eukaryotic initiation factor 3M via SAAL1 interaction in lung adenocarcinoma.,2024,10.62347/jktj7904,https://pubmed.ncbi.nlm.nih.gov/39553230/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,38650133,circ_JMJD1C expedites breast cancer progression by regulating miR-182-5p/JMJD1C/SOX4 axis.,2024,10.14715/cmb/2024.70.3.31,https://pubmed.ncbi.nlm.nih.gov/38650133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,38650379,The histone demethylase JMJD1C regulates CPS1 expression and promotes the proliferation of paroxysmal nocturnal haemoglobinuria clones through cell metabolic reprogramming.,2024,10.1111/bjh.19477,https://pubmed.ncbi.nlm.nih.gov/38650379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,41492215,Integrative Bioinformatics Reveals Novel Molecular Mechanisms and Therapeutic Targets in Acute Myeloid Leukaemia.,2026,10.1111/jcmm.71007,https://pubmed.ncbi.nlm.nih.gov/41492215/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,36429088,JMJD1C Regulates Megakaryopoiesis in In Vitro Models through the Actin Network.,2022,10.3390/cells11223660,https://pubmed.ncbi.nlm.nih.gov/36429088/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,39541663,Jia Wei Qingxin Lotus Seed Drink ameliorates epithelial mesenchymal transition injury in diabetic kidney disease via inhibition of JMJD1C/SP1/ZEB1 signaling pathway.,2024,10.1016/j.phymed.2024.156142,https://pubmed.ncbi.nlm.nih.gov/39541663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,41373783,Gene Polymorphisms Determining Sex Hormone-Binding Globulin Levels and Endometriosis Risk.,2025,10.3390/ijms262311630,https://pubmed.ncbi.nlm.nih.gov/41373783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,39915607,Methylstat sensitizes ovarian cancer cells to PARP-inhibition by targeting the histone demethylases JMJD1B/C.,2025,10.1038/s41417-025-00874-z,https://pubmed.ncbi.nlm.nih.gov/39915607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,34475205,AR-negative prostate cancer is vulnerable to loss of JMJD1C demethylase.,2021,10.1073/pnas.2026324118,https://pubmed.ncbi.nlm.nih.gov/34475205/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,40887646,Exploring the genetic intersection of dried fruit intake and breast cancer risk: a multi-trait genomic analysis with epidemiological context.,2025,10.1186/s41043-025-01059-y,https://pubmed.ncbi.nlm.nih.gov/40887646/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,41440942,Pharmacoepigenomics in Personalized Medicine: A Hypothesis-Generating Approach to Introduce CpG-PGx SNPs as New Candidates for a Systematic Insight into Genomic-Epigenomic-Phenomic-Pharmacogenomics (G-E-Ph-PGx) Axis.,2025,10.3390/jpm15120579,https://pubmed.ncbi.nlm.nih.gov/41440942/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,33075016,"JMJD1C knockdown affects myeloid cell lines proliferation, viability, and gemcitabine/carboplatin-sensitivity.",2021,10.1097/fpc.0000000000000422,https://pubmed.ncbi.nlm.nih.gov/33075016/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,34022910,Circular RNA circ_0006168 enhances Taxol resistance in esophageal squamous cell carcinoma by regulating miR-194-5p/JMJD1C axis.,2021,10.1186/s12935-021-01984-y,https://pubmed.ncbi.nlm.nih.gov/34022910/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,33289299,Modulators of histone demethylase JMJD1C selectively target leukemic stem cells.,2021,10.1002/2211-5463.13054,https://pubmed.ncbi.nlm.nih.gov/33289299/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,32017785,Jmjd1c is dispensable for healthy adult hematopoiesis and Jak2V617F-driven myeloproliferative disease initiation in mice.,2020,10.1371/journal.pone.0228362,https://pubmed.ncbi.nlm.nih.gov/32017785/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,35757472,A Novel Necroptosis-Related lncRNA Signature for Predicting Prognosis and Immune Response of Glioma.,2022,10.1155/2022/3742447,https://pubmed.ncbi.nlm.nih.gov/35757472/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,32610558,The Potential Effect of Aberrant Testosterone Levels on Common Diseases: A Mendelian Randomization Study.,2020,10.3390/genes11070721,https://pubmed.ncbi.nlm.nih.gov/32610558/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,36139405,Bioinformatic Analyses of Broad H3K79me2 Domains in Different Leukemia Cell Line Data Sets.,2022,10.3390/cells11182830,https://pubmed.ncbi.nlm.nih.gov/36139405/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMJD1C,ENSG00000171988,Unsafe,38532495,Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis.,2024,10.1186/s13293-024-00602-6,https://pubmed.ncbi.nlm.nih.gov/38532495/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,41748532,Junction-mediating and regulatory protein (JMY) is a promoting protein for radial migration of cortical neurons.,2026,10.1038/s41420-026-02974-7,https://pubmed.ncbi.nlm.nih.gov/41748532/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,42449410,A ROS/HIF-1α/JMY signaling axis drives radiation-induced migration and invasion of neural progenitor cells.,2026,10.1186/s12964-026-03025-5,https://pubmed.ncbi.nlm.nih.gov/42449410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,40788992,PCSK9 Loss-of-Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects.,2025,10.1002/advs.202504291,https://pubmed.ncbi.nlm.nih.gov/40788992/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,40817234,m6A-modified circZNF548 regulates exosomal miR-7108-3p to activate CD3&lt;sup&gt;+&lt;/sup&gt;CD8&lt;sup&gt;+&lt;/sup&gt; T cells and suppress NSCLC growth by JMY.,2025,10.1186/s12915-025-02355-z,https://pubmed.ncbi.nlm.nih.gov/40817234/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,40404909,"JMY powers dendritogenesis and is regulated by CaM revealing a general, critical principle in neuromorphogenesis.",2025,10.1038/s42003-025-08208-3,https://pubmed.ncbi.nlm.nih.gov/40404909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,39736291,Mmu_circ_0001148 promotes endothlial-mesenchymal transition via regulating miR-218-5p/JMY axis and drives progression of atherosclerosis.,2025,10.1016/j.ijbiomac.2024.139305,https://pubmed.ncbi.nlm.nih.gov/39736291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,38069185,Changes of Ex Vivo Cervical Epithelial Cells Due to Electroporation with JMY.,2023,10.3390/ijms242316863,https://pubmed.ncbi.nlm.nih.gov/38069185/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,37142657,p53-dependent DNA repair during the DNA damage response requires actin nucleation by JMY.,2023,10.1038/s41418-023-01170-9,https://pubmed.ncbi.nlm.nih.gov/37142657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,39682503,Identification and Preliminary Analysis of Granulosa Cell Biomarkers to Predict Oocyte In Vitro Maturation Outcome in the Southern White Rhinoceros (&lt;i&gt;Ceratotherium simum simum&lt;/i&gt;).,2024,10.3390/ani14233538,https://pubmed.ncbi.nlm.nih.gov/39682503/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,36012344,The p53 and Calcium Regulated Actin Rearrangement in Model Cells.,2022,10.3390/ijms23169078,https://pubmed.ncbi.nlm.nih.gov/36012344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,36920061,F-actin-rich territories coordinate apoptosome assembly and caspase activation during DNA damage-induced intrinsic apoptosis.,2023,10.1091/mbc.e22-04-0119,https://pubmed.ncbi.nlm.nih.gov/36920061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,39164442,Granulosa cells provide transcriptomic information on ovarian follicle dynamics in southern white rhinoceros.,2024,10.1038/s41598-024-70235-7,https://pubmed.ncbi.nlm.nih.gov/39164442/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,33128011,The HIF1α/JMY pathway promotes glioblastoma stem-like cell invasiveness after irradiation.,2020,10.1038/s41598-020-75300-5,https://pubmed.ncbi.nlm.nih.gov/33128011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,34326916,Exosomal miR-218-5p/miR-363-3p from Endothelial Progenitor Cells Ameliorate Myocardial Infarction by Targeting the p53/JMY Signaling Pathway.,2021,10.1155/2021/5529430,https://pubmed.ncbi.nlm.nih.gov/34326916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,33872315,The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3 complex-mediated intrinsic pathway of apoptosis.,2021,10.1371/journal.pgen.1009512,https://pubmed.ncbi.nlm.nih.gov/33872315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,37791865,Cardiomyopathy associated 5 (CMYA5) implicated as a genetic risk factor for radial hemimelia in Siamese cats.,2023,10.1177/1098612x231193557,https://pubmed.ncbi.nlm.nih.gov/37791865/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,32363797,Role of Junction-Mediating and Regulatory Protein in the Pathogenesis of Glucocorticoid-Induced Endothelial Cell Lesions.,2020,10.1111/os.12680,https://pubmed.ncbi.nlm.nih.gov/32363797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,31660455,"A Maternal Transcription Factor, Junction Mediating and Regulatory Protein is Required for Preimplantation Development in the Mouse.",2019,10.12717/dr.2019.23.3.285,https://pubmed.ncbi.nlm.nih.gov/31660455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,32279424,JMY expression by Sertoli cells contributes to mediating spermatogenesis in mice.,2020,10.1111/febs.15328,https://pubmed.ncbi.nlm.nih.gov/32279424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,34033782,WAVE regulatory complex.,2021,10.1016/j.cub.2021.01.086,https://pubmed.ncbi.nlm.nih.gov/34033782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,31831971,Anticancer activity of &lt;i&gt;Yashada Bhasma&lt;/i&gt; (bioactive nanoparticles of zinc): A human pancreatic cancer cell line study.,2019,10.4103/ayu.ayu_239_17,https://pubmed.ncbi.nlm.nih.gov/31831971/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,35041720,Integration of gene co-expression analysis and multi-class SVM specifies the functional players involved in determining the fate of HTLV-1 infection toward the development of cancer (ATLL) or neurological disorder (HAM/TSP).,2022,10.1371/journal.pone.0262739,https://pubmed.ncbi.nlm.nih.gov/35041720/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,35404226,Does total sleep time substantially increase after cognitive behavioral therapy for insomnia?,2022,10.5664/jcsm.10004,https://pubmed.ncbi.nlm.nih.gov/35404226/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,36713435,Activated autophagy of innate immune cells during the early stages of major trauma.,2022,10.3389/fimmu.2022.1090358,https://pubmed.ncbi.nlm.nih.gov/36713435/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,23758122,JMY polymorphism is related to severity of ankylosing spondylitis in Chinese Han patients.,2013,10.1089/gtmb.2013.0112,https://pubmed.ncbi.nlm.nih.gov/23758122/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,34804222,Comparison of Mechanical Performance between Circular Frames and Biplanar Distraction Devices for Knee Joint Distraction.,2021,10.5005/jp-journals-10080-1530,https://pubmed.ncbi.nlm.nih.gov/34804222/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,31776129,Dramatic increase in gene mutational burden after transformation of follicular lymphoma into TdT+ B-lymphoblastic leukemia/lymphoma.,2020,10.1101/mcs.a004614,https://pubmed.ncbi.nlm.nih.gov/31776129/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,28646090,Cellular functions of WASP family proteins at a glance.,2017,10.1242/jcs.199570,https://pubmed.ncbi.nlm.nih.gov/28646090/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,26305109,Wiskott-Aldrich syndrome proteins in the nucleus: aWASH with possibilities.,2015,10.1080/19491034.2015.1086051,https://pubmed.ncbi.nlm.nih.gov/26305109/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
JMY,ENSG00000152409,Unsafe,20237478,A nucleator arms race: cellular control of actin assembly.,2010,10.1038/nrm2867,https://pubmed.ncbi.nlm.nih.gov/20237478/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL1L,ENSG00000144445,Unsafe,37160609,Knockout mouse models as a resource for the study of rare diseases.,2023,10.1007/s00335-023-09986-z,https://pubmed.ncbi.nlm.nih.gov/37160609/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL1L,ENSG00000144445,Unsafe,42059165,Beyond MDM2 amplification: chromosomal translocations as diagnostic drivers in adipocytic tumours-a histopathological and molecular reappraisal.,2026,,https://pubmed.ncbi.nlm.nih.gov/42059165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL1L,ENSG00000144445,Unsafe,31803734,Screening of Methylation Signature and Gene Functions Associated With the Subtypes of Isocitrate Dehydrogenase-Mutation Gliomas.,2019,10.3389/fbioe.2019.00339,https://pubmed.ncbi.nlm.nih.gov/31803734/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL1L,ENSG00000144445,Unsafe,32692992,"New molecular insights into the pathogenesis of lipoblastomas: clinicopathologic, immunohistochemical, and molecular analysis in pediatric cases.",2020,10.1016/j.humpath.2020.07.016,https://pubmed.ncbi.nlm.nih.gov/32692992/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL1L,ENSG00000144445,Unsafe,32599975,Genome-Wide Association Study for the Identification of Novel Genetic Variants Associated with the Risk of Neuroblastoma in Korean Children.,2020,10.4143/crt.2020.140,https://pubmed.ncbi.nlm.nih.gov/32599975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL1L,ENSG00000144445,Unsafe,32724426,Genomic analysis of biomarkers related to the prognosis of acute myeloid leukemia.,2020,10.3892/ol.2020.11700,https://pubmed.ncbi.nlm.nih.gov/32724426/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL1L,ENSG00000144445,Unsafe,27030133,An evolutionary roadmap to the microtubule-associated protein MAP Tau.,2016,10.1186/s12864-016-2590-9,https://pubmed.ncbi.nlm.nih.gov/27030133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL1L,ENSG00000144445,Unsafe,23558233,Systems analysis of genetic variation in MPTP neurotoxicity in mice.,2013,10.1016/j.neuro.2013.03.010,https://pubmed.ncbi.nlm.nih.gov/23558233/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,41039555,TRAP1 inhibits KANSL3 acetylation to alleviate mitochondrial dysfunction by promoting mitophagy in cardiomyocytes under diabetic conditions.,2025,10.1186/s12964-025-02402-w,https://pubmed.ncbi.nlm.nih.gov/41039555/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,41044006,KANSL3 directs transcriptional programs essential for hepatic metabolism and differentiation.,2025,10.26508/lsa.202503238,https://pubmed.ncbi.nlm.nih.gov/41044006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,42608581,Integrative TWAS and multi-omics analyses prioritize HSPE1 as a candidate risk gene for bipolar disorder with immune cell-specific regulatory evidence.,2026,10.1007/s00406-026-02350-7,https://pubmed.ncbi.nlm.nih.gov/42608581/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,38769918,Loss of KANSL3 leads to defective inner cell mass and early embryonic lethality.,2024,10.1002/mrd.23760,https://pubmed.ncbi.nlm.nih.gov/38769918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,40281029,Gene expression analyses on Dickeya solani strains of diverse virulence levels unveil important pathogenicity factors for this species.,2025,10.1038/s41598-025-98321-4,https://pubmed.ncbi.nlm.nih.gov/40281029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,40100255,Hydrolysed Collagen Supplementation Enhances Patellar Tendon Adaptations to 12 Weeks' Resistance Training in Middle-Aged Men.,2025,10.1002/ejsc.12281,https://pubmed.ncbi.nlm.nih.gov/40100255/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,39639048,Polarization of road target detection under complex weather conditions.,2024,10.1038/s41598-024-80830-3,https://pubmed.ncbi.nlm.nih.gov/39639048/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,37161535,CRISPR-Cas9 knockout screen identifies novel treatment targets in childhood high-grade glioma.,2023,10.1186/s13148-023-01498-6,https://pubmed.ncbi.nlm.nih.gov/37161535/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,35416545,Two distinct males absent on the first (MOF)-containing histone acetyltransferases are involved in the epithelial-mesenchymal transition in different ways in human cells.,2022,10.1007/s00018-022-04258-6,https://pubmed.ncbi.nlm.nih.gov/35416545/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,35409160,The Non-Specific Lethal (NSL) Histone Acetyltransferase Complex Transcriptionally Regulates Yin Yang 1-Mediated Cell Proliferation in Human Cells.,2022,10.3390/ijms23073801,https://pubmed.ncbi.nlm.nih.gov/35409160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,37399316,The NSL complex is required for piRNA production from telomeric clusters.,2023,10.26508/lsa.202302194,https://pubmed.ncbi.nlm.nih.gov/37399316/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,31881804,O-GlcNAc-Modification of NSL3 at Thr755 Site Maintains the Holoenzyme Activity of MOF/NSL Histone Acetyltransfease Complex.,2019,10.3390/ijms21010173,https://pubmed.ncbi.nlm.nih.gov/31881804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,37624894,Transcriptional regulation by the NSL complex enables diversification of IFT functions in ciliated versus nonciliated cells.,2023,10.1126/sciadv.adh5598,https://pubmed.ncbi.nlm.nih.gov/37624894/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,36111046,"Exploration of new therapeutic targets for viral hepatic fibrosis, alcoholic hepatic fibrosis, and non-alcoholic hepatic fibrosis.",2022,10.21037/atm-22-3593,https://pubmed.ncbi.nlm.nih.gov/36111046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,35973998,"EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities.",2022,10.1038/s41419-022-05146-4,https://pubmed.ncbi.nlm.nih.gov/35973998/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,34430844,Influence of muscle fatigue on contractile twitch characteristics in persons with parkinson's disease and older adults: A pilot study.,2021,10.1016/j.prdoa.2021.100103,https://pubmed.ncbi.nlm.nih.gov/34430844/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,28450392,O-Linked N-acetylglucosamine transferase 1 regulates global histone H4 acetylation via stabilization of the nonspecific lethal protein NSL3.,2017,10.1074/jbc.m117.781401,https://pubmed.ncbi.nlm.nih.gov/28450392/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,31527906,RNAi-mediated depletion of the NSL complex subunits leads to abnormal chromosome segregation and defective centrosome duplication in Drosophila mitosis.,2019,10.1371/journal.pgen.1008371,https://pubmed.ncbi.nlm.nih.gov/31527906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,35819797,The integration host factor regulates multiple virulence pathways in bacterial pathogen Dickeya zeae MS2.,2022,10.1111/mpp.13244,https://pubmed.ncbi.nlm.nih.gov/35819797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,34151298,Generation of locus-specific degradable tag knock-ins in mouse and human cell lines.,2021,10.1016/j.xpro.2021.100575,https://pubmed.ncbi.nlm.nih.gov/34151298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,39273455,Genomic Insights into Pseudomonas protegens E1BL2 from Giant Jala Maize: A Novel Bioresource for Sustainable Agriculture and Efficient Management of Fungal Phytopathogens.,2024,10.3390/ijms25179508,https://pubmed.ncbi.nlm.nih.gov/39273455/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,29214169,Reversal of Proximal Renal Tubular Dysfunction after Nucleotide Analogue Withdrawal in Chronic Hepatitis B.,2017,10.1155/2017/4327385,https://pubmed.ncbi.nlm.nih.gov/29214169/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,25101526,Proximal renal tubular dysfunction related to antiretroviral therapy among HIV-infected patients in an HIV clinic in Mexico.,2015,10.1089/apc.2014.0134,https://pubmed.ncbi.nlm.nih.gov/25101526/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,18573931,Chronic administration of tenofovir to rhesus macaques from infancy through adulthood and pregnancy: summary of pharmacokinetics and biological and virological effects.,2008,10.1128/aac.00350-08,https://pubmed.ncbi.nlm.nih.gov/18573931/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,11546945,"The safety and efficacy of adefovir dipivoxil in patients with advanced HIV disease: a randomized, placebo-controlled trial.",2001,10.1097/00002030-200109070-00013,https://pubmed.ncbi.nlm.nih.gov/11546945/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KANSL3,ENSG00000114982,Unsafe,2007544,Cloning and expression in Escherichia coli of the Serratia marcescens metalloprotease gene: secretion of the protease from E. coli in the presence of the Erwinia chrysanthemi protease secretion functions.,1991,10.1128/jb.173.7.2160-2166.1991,https://pubmed.ncbi.nlm.nih.gov/2007544/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,42443317,Novel variants in LINC and TTM complexes of meiotic chromosome dynamics are associated with meiotic arrest and non-obstructive azoospermia.,2026,10.1038/s10038-026-01492-9,https://pubmed.ncbi.nlm.nih.gov/42443317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,36864840,"A homozygous KASH5 frameshift mutation causes diminished ovarian reserve, recurrent miscarriage, and non-obstructive azoospermia in humans.",2023,10.3389/fendo.2023.1128362,https://pubmed.ncbi.nlm.nih.gov/36864840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,36946995,The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein.,2023,10.1083/jcb.202204042,https://pubmed.ncbi.nlm.nih.gov/36946995/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,39086481,Characterization of latently infected EBV+ antibody-secreting B cells isolated from ovarian tumors and malignant ascites.,2024,10.3389/fimmu.2024.1379175,https://pubmed.ncbi.nlm.nih.gov/39086481/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,39545410,Defects in meiosis I contribute to the genesis of androgenetic hydatidiform moles.,2024,10.1172/jci170669,https://pubmed.ncbi.nlm.nih.gov/39545410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,35703493,The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor.,2022,10.7554/elife.78201,https://pubmed.ncbi.nlm.nih.gov/35703493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,33980926,A human infertility-associated KASH5 variant promotes mitochondrial localization.,2021,10.1038/s41598-021-89439-2,https://pubmed.ncbi.nlm.nih.gov/33980926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,35674372,Novel bi-allelic variants in KASH5 are associated with meiotic arrest and non-obstructive azoospermia.,2022,10.1093/molehr/gaac021,https://pubmed.ncbi.nlm.nih.gov/35674372/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,34039995,The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.,2021,10.1038/s41467-021-23550-w,https://pubmed.ncbi.nlm.nih.gov/34039995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,37520465,Molecular mimicry and COVID-19: Potential implications for global fertility.,2023,10.22099/mbrc.2023.47122.1819,https://pubmed.ncbi.nlm.nih.gov/37520465/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,31633067,Electron tomography of mouse LINC complexes at meiotic telomere attachment sites with and without microtubules.,2019,10.1038/s42003-019-0621-1,https://pubmed.ncbi.nlm.nih.gov/31633067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,36732629,Landscape of pathogenic mutations in premature ovarian insufficiency.,2023,10.1038/s41591-022-02194-3,https://pubmed.ncbi.nlm.nih.gov/36732629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,33238277,Fertility Relevance Probability Analysis Shortlists Genetic Markers for Male Fertility Impairment.,2020,10.1159/000511117,https://pubmed.ncbi.nlm.nih.gov/33238277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,24637401,The missing LINC: a mammalian KASH-domain protein coupling meiotic chromosomes to the cytoskeleton.,2014,10.4161/nucl.27819,https://pubmed.ncbi.nlm.nih.gov/24637401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,26842404,Depletion of the LINC complex disrupts cytoskeleton dynamics and meiotic resumption in mouse oocytes.,2016,10.1038/srep20408,https://pubmed.ncbi.nlm.nih.gov/26842404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,25380821,CDK2 regulates nuclear envelope protein dynamics and telomere attachment in mouse meiotic prophase.,2015,10.1242/jcs.154922,https://pubmed.ncbi.nlm.nih.gov/25380821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,37372436,Genomic Landscape of Copy Number Variations and Their Associations with Climatic Variables in the World's Sheep.,2023,10.3390/genes14061256,https://pubmed.ncbi.nlm.nih.gov/37372436/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,33058875,Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.,2020,10.1016/j.jmb.2020.09.019,https://pubmed.ncbi.nlm.nih.gov/33058875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,22826121,"A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.",2012,10.1083/jcb.201204085,https://pubmed.ncbi.nlm.nih.gov/22826121/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,29790874,Point-of-care whole-exome sequencing of idiopathic male infertility.,2018,10.1038/gim.2018.10,https://pubmed.ncbi.nlm.nih.gov/29790874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,27153397,Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation.,2016,10.1016/j.ajhg.2016.03.027,https://pubmed.ncbi.nlm.nih.gov/27153397/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KASH5,ENSG00000161609,Unsafe,35587281,"Homozygous missense mutation in CCDC155 disrupts the transmembrane distribution of CCDC155 and SUN1, resulting in non-obstructive azoospermia and premature ovarian insufficiency in humans.",2022,10.1007/s00439-022-02459-4,https://pubmed.ncbi.nlm.nih.gov/35587281/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,40668235,Fertility is compromised after oocyte-specific deletion of microtubule severing protein Katanin A1.,2025,10.1093/molehr/gaaf034,https://pubmed.ncbi.nlm.nih.gov/40668235/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,37882691,The katanin A-subunits KATNA1 and KATNAL1 act co-operatively in mammalian meiosis and spermiogenesis to achieve male fertility.,2023,10.1242/dev.201956,https://pubmed.ncbi.nlm.nih.gov/37882691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,42183984,Unveiling muscle fatigue: identifying key gene biomarkers and therapeutic targets.,2026,10.1007/s11010-026-05570-6,https://pubmed.ncbi.nlm.nih.gov/42183984/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,35752927,Common genetic variation in KATNAL1 non-coding regions is involved in the susceptibility to severe phenotypes of male infertility.,2022,10.1111/andr.13221,https://pubmed.ncbi.nlm.nih.gov/35752927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,39638877,miR-548az-5p induces amniotic epithelial cell senescence by regulating KATNAL1 expression in labor.,2024,10.1038/s41598-024-82390-y,https://pubmed.ncbi.nlm.nih.gov/39638877/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,39253718,Transcriptome analysis of four types of gonadal tissues in largemouth bass (Micropterus salmoides) to reveal its sex-related genes.,2024,10.3389/fgene.2024.1459427,https://pubmed.ncbi.nlm.nih.gov/39253718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,37758970,Circ-KATNAL1 Knockdown Reduces Neuronal Apoptosis and Alleviates Spinal Cord Injury Through the miR-98-5p/PRDM5 Regulatory Axis.,2024,10.1007/s12033-023-00895-9,https://pubmed.ncbi.nlm.nih.gov/37758970/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,35979014,circ-Katnal1 Enhances Inflammatory Pyroptosis in Sepsis-Induced Liver Injury through the miR-31-5p/GSDMD Axis.,2022,10.1155/2022/8950130,https://pubmed.ncbi.nlm.nih.gov/35979014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,30448058,"KATNAL1 is a more active and stable isoform of katanin, and is expressed dominantly in neurons.",2018,10.1016/j.bbrc.2018.11.048,https://pubmed.ncbi.nlm.nih.gov/30448058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,38692326,Gender-specific effects of polystyrene nanoplastic exposure on triclosan-induced reproductive toxicity in zebrafish (Danio rerio).,2024,10.1016/j.scitotenv.2024.172876,https://pubmed.ncbi.nlm.nih.gov/38692326/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,35635053,Circ_0008068 facilitates the oral squamous cell carcinoma development by microRNA-153-3p/acylgycerol kinase (AGK) axis.,2022,10.1080/21655979.2022.2074106,https://pubmed.ncbi.nlm.nih.gov/35635053/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,29136647,Katanin-like 2 (KATNAL2) functions in multiple aspects of haploid male germ cell development in the mouse.,2017,10.1371/journal.pgen.1007078,https://pubmed.ncbi.nlm.nih.gov/29136647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,33523351,Differential expression analysis and identification of sex-related genes by gonad transcriptome sequencing in estradiol-treated and non-treated Ussuri catfish Pseudobagrus ussuriensis.,2021,10.1007/s10695-021-00932-x,https://pubmed.ncbi.nlm.nih.gov/33523351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,33023587,A novel phenotype of 13q12.3 microdeletion characterized by epilepsy in an Asian child: a case report.,2020,10.1186/s12920-020-00801-1,https://pubmed.ncbi.nlm.nih.gov/33023587/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,22654668,KATNAL1 regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility.,2012,10.1371/journal.pgen.1002697,https://pubmed.ncbi.nlm.nih.gov/22654668/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,28373692,"A missense mutation in Katnal1 underlies behavioural, neurological and ciliary anomalies.",2018,10.1038/mp.2017.54,https://pubmed.ncbi.nlm.nih.gov/28373692/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,24990491,Association between an alternative promoter polymorphism and sperm deformity rate is due to modulation of the expression of KATNAL1 transcripts in Chinese Holstein bulls.,2014,10.1111/age.12182,https://pubmed.ncbi.nlm.nih.gov/24990491/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,29955027,Genomic and transcriptomic analyses reveal selection of genes for puberty in Bama Xiang pigs.,2018,10.24272/j.issn.2095-8137.2018.068,https://pubmed.ncbi.nlm.nih.gov/29955027/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,25506442,A new case of 13q12.2q13.1 microdeletion syndrome contributes to phenotype delineation.,2014,10.1155/2014/470830,https://pubmed.ncbi.nlm.nih.gov/25506442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,26929214,Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing.,2016,10.1074/mcp.m115.056465,https://pubmed.ncbi.nlm.nih.gov/26929214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KATNAL1,ENSG00000102781,Unsafe,28093975,Molecular Modeling and Dynamics Simulation Analysis of KATNAL1 for Identification of Novel Inhibitor of Sperm Maturation.,2017,10.2174/1386207320666170116120104,https://pubmed.ncbi.nlm.nih.gov/28093975/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KBTBD8,ENSG00000163376,Unsafe,41965527,Immune landscape of gingivo-buccal oral cancer indicates high enrichment of immune-related gene sets in tumors of a large proportion of patients.,2026,10.1186/s10020-026-01473-w,https://pubmed.ncbi.nlm.nih.gov/41965527/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KBTBD8,ENSG00000163376,Unsafe,39672234,KBTBD8/RRP15 as a potential novel therapeutic target associates with lenvatinib-inhibited progression in hepatocellular carcinoma both in vitro and in vivo.,2025,10.1016/j.jare.2024.12.017,https://pubmed.ncbi.nlm.nih.gov/39672234/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KBTBD8,ENSG00000163376,Unsafe,40584831,The joint role of the immune microenvironment and N&lt;sup&gt;7&lt;/sup&gt;-methylguanosine for prognosis prediction and targeted therapy in acute myeloid leukemia.,2025,10.3389/fgene.2025.1540992,https://pubmed.ncbi.nlm.nih.gov/40584831/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KBTBD8,ENSG00000163376,Unsafe,33109073,Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression.,2020,10.1186/s10020-020-00226-7,https://pubmed.ncbi.nlm.nih.gov/33109073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KBTBD8,ENSG00000163376,Unsafe,30786262,The ubiquitin ligase KBTBD8 regulates PKM1 levels via Erk1/2 and Aurora A to ensure oocyte quality.,2019,10.18632/aging.101802,https://pubmed.ncbi.nlm.nih.gov/30786262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KBTBD8,ENSG00000163376,Unsafe,37108346,"Effect of Genetic Factors, Age and Sex on Levels of Circulating Extracellular Vesicles and Platelets.",2023,10.3390/ijms24087183,https://pubmed.ncbi.nlm.nih.gov/37108346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KBTBD8,ENSG00000163376,Unsafe,35176998,Evaluating the cytotoxicity and pathogenicity of multi-walled carbon nanotube through weighted gene co-expression network analysis: a nanotoxicogenomics study.,2022,10.1186/s12863-022-01031-3,https://pubmed.ncbi.nlm.nih.gov/35176998/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KBTBD8,ENSG00000163376,Unsafe,29999490,Multisite dependency of an E3 ligase controls monoubiquitylation-dependent cell fate decisions.,2018,10.7554/elife.35407,https://pubmed.ncbi.nlm.nih.gov/29999490/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KBTBD8,ENSG00000163376,Unsafe,31848607,Population History and Gene Divergence in Native Mexicans Inferred from 76 Human Exomes.,2020,10.1093/molbev/msz282,https://pubmed.ncbi.nlm.nih.gov/31848607/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KBTBD8,ENSG00000163376,Unsafe,23578279,"The novel BTB-kelch protein, KBTBD8, is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis.",2013,10.1186/1747-1028-8-3,https://pubmed.ncbi.nlm.nih.gov/23578279/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KBTBD8,ENSG00000163376,Unsafe,26399832,Cell-fate determination by ubiquitin-dependent regulation of translation.,2015,10.1038/nature14978,https://pubmed.ncbi.nlm.nih.gov/26399832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KBTBD8,ENSG00000163376,Unsafe,27539004,Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus.,2017,10.1002/tox.22335,https://pubmed.ncbi.nlm.nih.gov/27539004/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,42793093,&lt;i&gt;Kcna3&lt;/i&gt; Deficiency Promotes Renin-Associated Hypertension Through Ca&lt;sup&gt;2+&lt;/sup&gt;-Dependent AKT-PKA-CREB Signaling.,2026,10.3390/biom16091262,https://pubmed.ncbi.nlm.nih.gov/42793093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,42843269,Modular secondary-antibody-based SERS immunoprobes for detecting membrane-associated proteins in adherent cells.,2026,10.1016/j.saa.2026.128910,https://pubmed.ncbi.nlm.nih.gov/42843269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,41948606,Immunomodulatory Roles and Clinical Significance of GZMM and DDX24 in Sepsis: A Multiomics Integrative Analysis With Experimental Validation.,2026,10.1155/humu/4951633,https://pubmed.ncbi.nlm.nih.gov/41948606/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,42487278,Psoriasis-Obesity-Related Gene COX7C Promotes Keratinocyte Proliferation and Positively Regulates Inflammatory Responses in Psoriasis.,2026,10.1111/jcmm.71277,https://pubmed.ncbi.nlm.nih.gov/42487278/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,41155561,Pharmacological Actions of Potassium Channel Openers on Voltage-Gated Potassium Channels.,2025,10.3390/ph18101446,https://pubmed.ncbi.nlm.nih.gov/41155561/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,42433653,Identification and validation of aging-related genes in patients with multiple myeloma.,2026,10.3892/ol.2026.15739,https://pubmed.ncbi.nlm.nih.gov/42433653/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,42341914,Kv1.3 modulates macrophage M2 polarization via the STAT3 pathway: A novel mechanism and therapeutic target for steroid-resistant asthma.,2026,10.1016/j.trsl.2026.06.020,https://pubmed.ncbi.nlm.nih.gov/42341914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,42158856,Identification of characteristic hub genes in the immune-active phase of chronic hepatitis B.,2026,10.3389/fimmu.2026.1769749,https://pubmed.ncbi.nlm.nih.gov/42158856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,40595897,Integrated analysis identifies key genes underlying the bidirectional association between depression and renal failure.,2025,10.1038/s41598-025-04707-9,https://pubmed.ncbi.nlm.nih.gov/40595897/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,42450133,Comparative Interactome Analysis Reveals Architectural Principles Governing K&lt;sup&gt;+&lt;/sup&gt; Channel Function in Cancer.,2026,10.3390/ijms27135862,https://pubmed.ncbi.nlm.nih.gov/42450133/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,40102965,Fibroblast IRF7-mediated chondrocyte apoptosis affects the progression of collapse in steroid-induced osteonecrosis of the femoral head.,2025,10.1186/s13018-025-05557-x,https://pubmed.ncbi.nlm.nih.gov/40102965/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,40409708,Disease-associated Kv1.3 Variants are Energy Compromised with Impaired Nascent Chain Folding.,2025,10.1016/j.jmb.2025.169226,https://pubmed.ncbi.nlm.nih.gov/40409708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,38898907,"Newly Identified &lt;i&gt;KCNA3&lt;/i&gt; Gene Variants Put the ""Excite""-ment Back in Kv1.3 Channelopathy.",2024,10.1177/15357597241234244,https://pubmed.ncbi.nlm.nih.gov/38898907/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,41082457,Genetic Association in Immunoglobulin G4-Related Disease: A Systematic Review.,2026,10.1159/000548893,https://pubmed.ncbi.nlm.nih.gov/41082457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,40860865,Escalated oxycodone self-administration is associated with expression of voltage gated and calcium activated potassium channels in the mesocorticolimbic system in rats.,2025,10.3389/fphar.2025.1653356,https://pubmed.ncbi.nlm.nih.gov/40860865/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,37650127,Genome-wide methylation profiling identified methylated KCNA3 and OTOP2 as promising diagnostic markers for esophageal squamous cell carcinoma.,2024,10.1097/cm9.0000000000002832,https://pubmed.ncbi.nlm.nih.gov/37650127/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,39998707,Identification of KCNJ5 gene an adverse prognosis associated novel onco-ionchannel in Indian pancreatic cancer cohort.,2025,10.1007/s12672-025-02001-8,https://pubmed.ncbi.nlm.nih.gov/39998707/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,36978819,A Meta-Analysis Study to Infer Voltage-Gated K+ Channels Prognostic Value in Different Cancer Types.,2023,10.3390/antiox12030573,https://pubmed.ncbi.nlm.nih.gov/36978819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,41145087,Cell type-specific methylome-wide association studies of childhood ADHD symptoms.,2025,10.1016/j.euroneuro.2025.09.010,https://pubmed.ncbi.nlm.nih.gov/41145087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,39709429,"Correction: Non-invasive diagnosis of esophageal cancer by a simplified circulating cell-free DNA methylation assay targeting OTOP2 and KCNA3: a double-blinded, multicenter, prospective study.",2024,10.1186/s13045-024-01653-3,https://pubmed.ncbi.nlm.nih.gov/39709429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,40035659,"Consistent Safety and Efficacy of Sotatercept for Pulmonary Arterial Hypertension in &lt;i&gt;BMPR2&lt;/i&gt; Mutation Carriers and Noncarriers: A Planned Analysis of a Phase II, Double-Blind, Placebo-controlled Clinical Trial (PULSAR).",2025,10.1164/rccm.202409-1698oc,https://pubmed.ncbi.nlm.nih.gov/40035659/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,38890756,"Non-invasive diagnosis of esophageal cancer by a simplified circulating cell-free DNA methylation assay targeting OTOP2 and KCNA3: a double-blinded, multicenter, prospective study.",2024,10.1186/s13045-024-01565-2,https://pubmed.ncbi.nlm.nih.gov/38890756/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,34868239,Identification of Immune-Related Key Genes in Ovarian Cancer Based on WGCNA.,2021,10.3389/fgene.2021.760225,https://pubmed.ncbi.nlm.nih.gov/34868239/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,36852591,Characterization of endogenous Kv1.3 channel isoforms in T cells.,2023,10.1002/jcp.30984,https://pubmed.ncbi.nlm.nih.gov/36852591/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,36106139,A Potential Anticancer Mechanism of Finger Root (Boesenbergia rotunda) Extracts against a Breast Cancer Cell Line.,2022,10.1155/2022/9130252,https://pubmed.ncbi.nlm.nih.gov/36106139/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,36091949,Multi-omics analysis to screen potential therapeutic biomarkers for anti-cancer compounds.,2022,10.1016/j.heliyon.2022.e09616,https://pubmed.ncbi.nlm.nih.gov/36091949/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,35864995,Predicted Immune-Related Genes and Subtypes in Systemic Lupus Erythematosus Based on Immune Infiltration Analysis.,2022,10.1155/2022/8911321,https://pubmed.ncbi.nlm.nih.gov/35864995/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,34248635,Loureirin B Exerts its Immunosuppressive Effects by Inhibiting STIM1/Orai1 and KV1.3 Channels.,2021,10.3389/fphar.2021.685092,https://pubmed.ncbi.nlm.nih.gov/34248635/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNA3,ENSG00000177272,Unsafe,31448055,Expression and function of Kv1.3 channel in malignant T cells in Sézary syndrome.,2019,10.18632/oncotarget.27122,https://pubmed.ncbi.nlm.nih.gov/31448055/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,41656275,Crosstalk of KCNH1 and KCNH5 gain-of-function mutations leading to epilepsy and neurodevelopmental disorders.,2026,10.1186/s13041-026-01279-1,https://pubmed.ncbi.nlm.nih.gov/41656275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,38813969,Thalamic activity-dependent specification of sensory input neurons in the developing chick entopallium.,2024,10.1002/cne.25627,https://pubmed.ncbi.nlm.nih.gov/38813969/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,39085070,A Novel De Novo Variant in KCNH5 in a Patient with Refractory Epileptic Encephalopathy.,2025,10.2169/internalmedicine.3999-24,https://pubmed.ncbi.nlm.nih.gov/39085070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,38797494,KCNH5 deletion increases autism susceptibility by regulating neuronal growth through Akt/mTOR signaling pathway.,2024,10.1016/j.bbr.2024.115069,https://pubmed.ncbi.nlm.nih.gov/38797494/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,38708366,Clinical phenotypes of developmental and epileptic encephalopathy-related recurrent KCNH5 missense variant p.R327H in Chinese children.,2024,10.1016/j.ebr.2024.100671,https://pubmed.ncbi.nlm.nih.gov/38708366/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,37697045,A designer peptide against the EAG2-Kvβ2 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma.,2023,10.1038/s43018-023-00626-8,https://pubmed.ncbi.nlm.nih.gov/37697045/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,41110851,Fentanyl blockade of K&lt;sup&gt;+&lt;/sup&gt; channels contributes to wooden chest syndrome.,2026,10.1113/jp289107,https://pubmed.ncbi.nlm.nih.gov/41110851/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,36307226,Neurodevelopmental and Epilepsy Phenotypes in Individuals With Missense Variants in the Voltage-Sensing and Pore Domains of KCNH5.,2023,10.1212/wnl.0000000000201492,https://pubmed.ncbi.nlm.nih.gov/36307226/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,39434833,Voltage-gated potassium channels and genetic epilepsy.,2024,10.3389/fneur.2024.1466075,https://pubmed.ncbi.nlm.nih.gov/39434833/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,35874597,"Clinical Feature, Treatment, and KCNH5 Mutations in Epilepsy.",2022,10.3389/fped.2022.858008,https://pubmed.ncbi.nlm.nih.gov/35874597/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,37372468,Genome-Wide Search for Associations with Meat Production Parameters in Karachaevsky Sheep Breed Using the Illumina BeadChip 600 K.,2023,10.3390/genes14061288,https://pubmed.ncbi.nlm.nih.gov/37372468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,35784838,Integrated Analysis of Expression Profile and Potential Pathogenic Mechanism of Temporal Lobe Epilepsy With Hippocampal Sclerosis.,2022,10.3389/fnins.2022.892022,https://pubmed.ncbi.nlm.nih.gov/35784838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,32097463,Chloride intracellular channel 1 cooperates with potassium channel EAG2 to promote medulloblastoma growth.,2020,10.1084/jem.20190971,https://pubmed.ncbi.nlm.nih.gov/32097463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,33833419,"Regional heritability mapping identifies several novel loci (STAT4, ULK4, and KCNH5) for primary biliary cholangitis in the Japanese population.",2021,10.1038/s41431-021-00854-5,https://pubmed.ncbi.nlm.nih.gov/33833419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,32222671,Rescuing Kv10.2 protein changes cognitive and emotional function in kainic acid-induced status epilepticus rats.,2020,10.1016/j.yebeh.2019.106894,https://pubmed.ncbi.nlm.nih.gov/32222671/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,39855736,Effect of CXCR2 Deficiency in HeLa Cell on the Regulatory Network of Coding Genes and Non-Coding RNAs.,2024,,https://pubmed.ncbi.nlm.nih.gov/39855736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,36928654,Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel.,2023,10.1038/s41467-023-37204-6,https://pubmed.ncbi.nlm.nih.gov/36928654/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,30441852,"Cardiac Targeting Peptide, a Novel Cardiac Vector: Studies in Bio-Distribution, Imaging Application, and Mechanism of Transduction.",2018,10.3390/biom8040147,https://pubmed.ncbi.nlm.nih.gov/30441852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,24759919,Retrotransposon hypomethylation in melanoma and expression of a placenta-specific gene.,2014,10.1371/journal.pone.0095840,https://pubmed.ncbi.nlm.nih.gov/24759919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,33839593,"Comparative analysis of triple-negative breast cancer transcriptomics of Kenyan, African American and Caucasian Women.",2021,10.1016/j.tranon.2021.101086,https://pubmed.ncbi.nlm.nih.gov/33839593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,26258683,EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.,2015,10.1038/nn.4088,https://pubmed.ncbi.nlm.nih.gov/26258683/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,19945765,DNA hypermethylation of tumors from non-small cell lung cancer (NSCLC) patients is associated with gender and histologic type.,2010,10.1016/j.lungcan.2009.11.002,https://pubmed.ncbi.nlm.nih.gov/19945765/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,23647072,Exome sequencing reveals new causal mutations in children with epileptic encephalopathies.,2013,10.1111/epi.12201,https://pubmed.ncbi.nlm.nih.gov/23647072/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,18349282,DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients.,2008,10.1158/1055-9965.epi-07-2518,https://pubmed.ncbi.nlm.nih.gov/18349282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,19850283,"Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.",2010,10.1016/j.biopsych.2009.08.030,https://pubmed.ncbi.nlm.nih.gov/19850283/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNH5,ENSG00000140015,Unsafe,20398362,Functional neural differentiation of human adipose tissue-derived stem cells using bFGF and forskolin.,2010,10.1186/1471-2121-11-25,https://pubmed.ncbi.nlm.nih.gov/20398362/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNJ14,ENSG00000182324,Unsafe,41124752,High KCNJ14 expression is associated with an immunosuppressive tumor microenvironment and advanced pathological features: An RNA in situ hybridization-based analysis of colorectal carcinoma.,2025,10.1016/j.yexmp.2025.105005,https://pubmed.ncbi.nlm.nih.gov/41124752/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNJ14,ENSG00000182324,Unsafe,42523149,Novel blood lncRNA biomarkers associated with clinical severity and specific cognitive dimensions in Alzheimer's disease.,2026,10.1177/13872877261470430,https://pubmed.ncbi.nlm.nih.gov/42523149/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNJ14,ENSG00000182324,Unsafe,42120987,Expanding the genetic and clinical landscapes of hereditary spastic paraplegia (HSP): a cohort study of 103 families.,2026,10.1186/s13023-026-04373-8,https://pubmed.ncbi.nlm.nih.gov/42120987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNJ14,ENSG00000182324,Unsafe,36768373,Comprehensive Analysis of KCNJ14 Potassium Channel as a Biomarker for Cancer Progression and Development.,2023,10.3390/ijms24032049,https://pubmed.ncbi.nlm.nih.gov/36768373/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNJ14,ENSG00000182324,Unsafe,36100894,KCNJ14 knockdown significantly inhibited the proliferation and migration of colorectal cells.,2022,10.1186/s12920-022-01351-4,https://pubmed.ncbi.nlm.nih.gov/36100894/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNJ14,ENSG00000182324,Unsafe,40041860,Identification of cancer-associated fibroblast signature genes for prognostic prediction in colorectal cancer.,2025,10.3389/fgene.2025.1476092,https://pubmed.ncbi.nlm.nih.gov/40041860/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNJ14,ENSG00000182324,Unsafe,34222322,Prognostic Nomogram of Prognosis-Related Genes and Clinicopathological Characteristics to Predict the 5-Year Survival Rate of Colon Cancer Patients.,2021,10.3389/fsurg.2021.681721,https://pubmed.ncbi.nlm.nih.gov/34222322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNJ14,ENSG00000182324,Unsafe,31934309,Novel eye genes systematically discovered through an integrated analysis of mouse transcriptomes and phenome.,2020,10.1016/j.csbj.2019.12.009,https://pubmed.ncbi.nlm.nih.gov/31934309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNJ14,ENSG00000182324,Unsafe,26655723,Electrogenic transport and K(+) ion channel expression by the human endolymphatic sac epithelium.,2015,10.1038/srep18110,https://pubmed.ncbi.nlm.nih.gov/26655723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNJ14,ENSG00000182324,Unsafe,33020178,Cardiophysiological responses of the air-breathing Alaska blackfish to cold acclimation and chronic hypoxic submergence at 5°C.,2020,10.1242/jeb.225730,https://pubmed.ncbi.nlm.nih.gov/33020178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNJ14,ENSG00000182324,Unsafe,29205356,Molecular and functional characterization of inwardly rectifying K+ currents in murine proximal colon.,2018,10.1113/jp275234,https://pubmed.ncbi.nlm.nih.gov/29205356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNJ14,ENSG00000182324,Unsafe,23889090,Altered expression of genes for Kir ion channels in dilated cardiomyopathy.,2013,10.1139/cjpp-2012-0413,https://pubmed.ncbi.nlm.nih.gov/23889090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNJ14,ENSG00000182324,Unsafe,25063199,Molecular cloning of ion channels in Felis catus that are related to periodic paralyses in man: a contribution to the understanding of the genetic susceptibility to feline neck ventroflexion and paralysis.,2014,10.1242/bio.20148003,https://pubmed.ncbi.nlm.nih.gov/25063199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNJ14,ENSG00000182324,Unsafe,23913861,The challenging environment on board the International Space Station affects endothelial cell function by triggering oxidative stress through thioredoxin interacting protein overexpression: the ESA-SPHINX experiment.,2013,10.1096/fj.13-229195,https://pubmed.ncbi.nlm.nih.gov/23913861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNJ14,ENSG00000182324,Unsafe,9592090,Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei.,1998,10.1523/jneurosci.18-11-04096.1998,https://pubmed.ncbi.nlm.nih.gov/9592090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNJ14,ENSG00000182324,Unsafe,10942728,"Cloning and functional expression of human retinal kir2.4, a pH-sensitive inwardly rectifying K(+) channel.",2000,10.1152/ajpcell.2000.279.3.c771,https://pubmed.ncbi.nlm.nih.gov/10942728/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNK13,ENSG00000152315,Unsafe,42829399,Association between BDNF methylation and expression of the NLRP3 inflammasome in the brain is disrupted in Alzheimer's disease.,2026,10.1007/s00702-026-03280-3,https://pubmed.ncbi.nlm.nih.gov/42829399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNK13,ENSG00000152315,Unsafe,38746889,"Discovery of CVN293, a Brain Permeable KCNK13 (THIK-1) Inhibitor Suitable for Clinical Assessment.",2024,10.1021/acsmedchemlett.4c00035,https://pubmed.ncbi.nlm.nih.gov/38746889/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNK13,ENSG00000152315,Unsafe,37718820,Elevated Expression of Two Pore Potassium Channel THIK-1 in Alzheimer's Disease: An Inflammatory Mechanism.,2023,10.3233/jad-230616,https://pubmed.ncbi.nlm.nih.gov/37718820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNK13,ENSG00000152315,Unsafe,33960499,KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of ventral tegmental area neurons by ethanol.,2021,10.1111/acer.14630,https://pubmed.ncbi.nlm.nih.gov/33960499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNK13,ENSG00000152315,Unsafe,40011745,Cryo-EM structure of the human THIK-1 K2P K&lt;sup&gt;+&lt;/sup&gt; channel reveals a lower Y gate regulated by lipids and anesthetics.,2025,10.1038/s41594-025-01497-6,https://pubmed.ncbi.nlm.nih.gov/40011745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNK13,ENSG00000152315,Unsafe,35743793,Researching Mitigation of Alcohol Binge Drinking in Polydrug Abuse: KCNK13 and RASGRF2 Gene(s) Risk Polymorphisms Coupled with Genetic Addiction Risk Severity (GARS) Guiding Precision Pro-Dopamine Regulation.,2022,10.3390/jpm12061009,https://pubmed.ncbi.nlm.nih.gov/35743793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNK13,ENSG00000152315,Unsafe,40256241,The diagnostic and prognostic value of &lt;i&gt;C1orf174&lt;/i&gt; in colorectal cancer.,2025,10.34172/bi.30566,https://pubmed.ncbi.nlm.nih.gov/40256241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNK13,ENSG00000152315,Unsafe,30332606,Ethanol acts on KCNK13 potassium channels in the ventral tegmental area to increase firing rate and modulate binge-like drinking.,2019,10.1016/j.neuropharm.2018.10.008,https://pubmed.ncbi.nlm.nih.gov/30332606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNK13,ENSG00000152315,Unsafe,38236765,"Comparative Gene Signature of Nociceptors Innervating Mouse Molar Teeth, Cranial Meninges, and Cornea.",2024,10.1213/ane.0000000000006816,https://pubmed.ncbi.nlm.nih.gov/38236765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNK13,ENSG00000152315,Unsafe,38082150,Identification of genetic variants and individual genes associated with postpartum hypocalcemia in Holstein cows.,2023,10.1038/s41598-023-49496-1,https://pubmed.ncbi.nlm.nih.gov/38082150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNK13,ENSG00000152315,Unsafe,32860629,TASK-1 channel blockade by AVE1231 increases vasocontractile responses and BP in 1- to 2-week-old but not adult rats.,2020,10.1111/bph.15249,https://pubmed.ncbi.nlm.nih.gov/32860629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNK13,ENSG00000152315,Unsafe,30472253,Cloning and characterization of zebrafish K2P13.1 (THIK-1) two-pore-domain K+ channels.,2019,10.1016/j.yjmcc.2018.11.013,https://pubmed.ncbi.nlm.nih.gov/30472253/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNK13,ENSG00000152315,Unsafe,20673313,Identification and characterization of Cs(+) -permeable K(+) channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation.,2010,10.1111/j.1460-9568.2010.07336.x,https://pubmed.ncbi.nlm.nih.gov/20673313/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNK13,ENSG00000152315,Unsafe,22273507,Leak K⁺ channel mRNAs in dorsal root ganglia: relation to inflammation and spontaneous pain behaviour.,2012,10.1016/j.mcn.2012.01.002,https://pubmed.ncbi.nlm.nih.gov/22273507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNK13,ENSG00000152315,Unsafe,18209473,Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.,2008,10.1159/000113748,https://pubmed.ncbi.nlm.nih.gov/18209473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNK13,ENSG00000152315,Unsafe,38409076,Differential contribution of THIK-1 K+ channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia.,2024,10.1186/s12974-024-03042-6,https://pubmed.ncbi.nlm.nih.gov/38409076/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,41419946,FOXP3-activated KCNMB2-AS1 promotes clear cell renal cell carcinoma through the miR-744-3p/CD1D axis.,2025,10.1186/s13008-025-00177-7,https://pubmed.ncbi.nlm.nih.gov/41419946/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,42529199,"Blood transcriptomic signatures link β-amyloid deposition to molecular pathways across SCD, MCI, and dementia.",2026,10.3389/fnagi.2026.1816733,https://pubmed.ncbi.nlm.nih.gov/42529199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,42010553,Molecular markers for cervical cancer prognosis: a prognostic model using stemness-related lncRNAs and functional analysis of EMX2OS.,2026,10.1186/s12885-026-16022-1,https://pubmed.ncbi.nlm.nih.gov/42010553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,42016167,Association study uncovers obesity-linked variants in mobile elements as potential regulators of gene expression.,2026,10.1016/j.isci.2026.115376,https://pubmed.ncbi.nlm.nih.gov/42016167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,41367010,Investigating the prognostic potential of PTPN11 gene in papillary thyroid carcinoma: A comprehensive study of bulk and single cell transcriptome.,2025,10.1097/md.0000000000046315,https://pubmed.ncbi.nlm.nih.gov/41367010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,37710992,Long noncoding RNA KCNMB2-AS1 acts as an oncogene in ovarian cancer.,2023,10.3724/abbs.2023228,https://pubmed.ncbi.nlm.nih.gov/37710992/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,36157207,Gene Expression Trajectories from Normal Nonsmokers to COPD Smokers and Disease Progression Discriminant Modeling in Response to Cigarette Smoking.,2022,10.1155/2022/9354286,https://pubmed.ncbi.nlm.nih.gov/36157207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,34516362,Long noncoding RNA KCNMB2-AS1 promotes the development of esophageal cancer by modulating the miR-3194-3p/PYGL axis.,2021,10.1080/21655979.2021.1973775,https://pubmed.ncbi.nlm.nih.gov/34516362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,39756494,Transcriptional profiling of exosomes derived from serum of patients with rare earth pneumoconiosis by RNA-sequencing and PI3K/Akt pathway is activated in lung of mice exposed to rare earth Nd2O3.,2025,10.1016/j.toxlet.2025.01.001,https://pubmed.ncbi.nlm.nih.gov/39756494/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,39701680,[Molecular mechanism of Xiangsha Liujunzi Decoction in treating chronic atrophic gastritis based on transcriptome sequencing technology].,2024,10.19540/j.cnki.cjcmm.20240509.401,https://pubmed.ncbi.nlm.nih.gov/39701680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,38473810,Transcriptomic Analysis Reveals Intrinsic Abnormalities in Endometrial Polyps.,2024,10.3390/ijms25052557,https://pubmed.ncbi.nlm.nih.gov/38473810/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,34026626,Long Noncoding RNA KCNMB2-AS1 Promotes SMAD5 by Targeting miR-3194-3p to Induce Bladder Cancer Progression.,2021,10.3389/fonc.2021.649778,https://pubmed.ncbi.nlm.nih.gov/34026626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,36203817,"Effect of an autism-associated KCNMB2 variant, G124R, on BK channel properties.",2022,10.1016/j.crphys.2022.09.001,https://pubmed.ncbi.nlm.nih.gov/36203817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,34367236,KCNMB2-AS1 Promotes Bladder Cancer Progression Through Sponging miR-374a-3p to Upregulate S100A10.,2021,10.3389/fgene.2021.655569,https://pubmed.ncbi.nlm.nih.gov/34367236/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,35979065,Long Noncoding RNA KCNMB2-AS1 Increases ROCK1 Expression by Sponging microRNA-374a-3p to Facilitate the Progression of Non-Small-Cell Lung Cancer [Retraction].,2022,10.2147/cmar.s385608,https://pubmed.ncbi.nlm.nih.gov/35979065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,33335424,Long Noncoding RNA KCNMB2-AS1 Increases ROCK1 Expression by Sponging microRNA-374a-3p to Facilitate the Progression of Non-Small-Cell Lung Cancer.,2020,10.2147/cmar.s270646,https://pubmed.ncbi.nlm.nih.gov/33335424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,34526147,"Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study.",2021,10.1186/s40478-021-01250-2,https://pubmed.ncbi.nlm.nih.gov/34526147/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,33028109,Long Noncoding RNA KCNMB2-AS1 Stabilized by N6-Methyladenosine Modification Promotes Cervical Cancer Growth Through Acting as a Competing Endogenous RNA.,2020,10.1177/0963689720964382,https://pubmed.ncbi.nlm.nih.gov/33028109/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,34707415,Long Noncoding RNA KCNMB2-AS1 Increases ROCK1 Expression by Sponging microRNA-374a-3p to Facilitate the Progression of Non-Small-Cell Lung Cancer [Expression of Concern].,2021,10.2147/cmar.s344580,https://pubmed.ncbi.nlm.nih.gov/34707415/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,30405352,Overexpression of Kcnmb2 in Dorsal CA1 of Offspring Mice Rescues Hippocampal Dysfunction Caused by a Methyl Donor-Rich Paternal Diet.,2018,10.3389/fncel.2018.00360,https://pubmed.ncbi.nlm.nih.gov/30405352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,32371615,Effects of KCNMB2 gene polymorphisms on ritodrine therapy outcomes in women with preterm labor.,2020,10.1097/fpc.0000000000000404,https://pubmed.ncbi.nlm.nih.gov/32371615/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,28373690,A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice.,2018,10.1038/mp.2017.53,https://pubmed.ncbi.nlm.nih.gov/28373690/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,35909518,Bioinformatics Analysis of the Mechanisms of Diabetic Nephropathy via Novel Biomarkers and Competing Endogenous RNA Network.,2022,10.3389/fendo.2022.934022,https://pubmed.ncbi.nlm.nih.gov/35909518/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,28131462,"Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2.",2017,10.1016/j.neurobiolaging.2017.01.003,https://pubmed.ncbi.nlm.nih.gov/28131462/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,27003218,"Hippocampal Sclerosis of Aging, a Common Alzheimer's Disease 'Mimic': Risk Genotypes are Associated with Brain Atrophy Outside the Temporal Lobe.",2016,10.3233/jad-160077,https://pubmed.ncbi.nlm.nih.gov/27003218/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,28189700,CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.,2017,10.1016/j.exger.2017.01.025,https://pubmed.ncbi.nlm.nih.gov/28189700/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,24414257,"IFN-γ-mediated reduction of large-conductance, Ca2+-activated, voltage-dependent K+ (BK) channel activity in airway epithelial cells leads to mucociliary dysfunction.",2014,10.1152/ajplung.00247.2013,https://pubmed.ncbi.nlm.nih.gov/24414257/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,10692449,"Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4.",2000,10.1074/jbc.275.9.6453,https://pubmed.ncbi.nlm.nih.gov/10692449/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,10377337,Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells.,1999,10.1523/jneurosci.19-13-05255.1999,https://pubmed.ncbi.nlm.nih.gov/10377337/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB2,ENSG00000197584,Unsafe,10097176,Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog.,1999,10.1073/pnas.96.7.4137,https://pubmed.ncbi.nlm.nih.gov/10097176/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,41419946,FOXP3-activated KCNMB2-AS1 promotes clear cell renal cell carcinoma through the miR-744-3p/CD1D axis.,2025,10.1186/s13008-025-00177-7,https://pubmed.ncbi.nlm.nih.gov/41419946/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,42529199,"Blood transcriptomic signatures link β-amyloid deposition to molecular pathways across SCD, MCI, and dementia.",2026,10.3389/fnagi.2026.1816733,https://pubmed.ncbi.nlm.nih.gov/42529199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,42010553,Molecular markers for cervical cancer prognosis: a prognostic model using stemness-related lncRNAs and functional analysis of EMX2OS.,2026,10.1186/s12885-026-16022-1,https://pubmed.ncbi.nlm.nih.gov/42010553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,42016167,Association study uncovers obesity-linked variants in mobile elements as potential regulators of gene expression.,2026,10.1016/j.isci.2026.115376,https://pubmed.ncbi.nlm.nih.gov/42016167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,41367010,Investigating the prognostic potential of PTPN11 gene in papillary thyroid carcinoma: A comprehensive study of bulk and single cell transcriptome.,2025,10.1097/md.0000000000046315,https://pubmed.ncbi.nlm.nih.gov/41367010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,37710992,Long noncoding RNA KCNMB2-AS1 acts as an oncogene in ovarian cancer.,2023,10.3724/abbs.2023228,https://pubmed.ncbi.nlm.nih.gov/37710992/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,36157207,Gene Expression Trajectories from Normal Nonsmokers to COPD Smokers and Disease Progression Discriminant Modeling in Response to Cigarette Smoking.,2022,10.1155/2022/9354286,https://pubmed.ncbi.nlm.nih.gov/36157207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,34516362,Long noncoding RNA KCNMB2-AS1 promotes the development of esophageal cancer by modulating the miR-3194-3p/PYGL axis.,2021,10.1080/21655979.2021.1973775,https://pubmed.ncbi.nlm.nih.gov/34516362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,39756494,Transcriptional profiling of exosomes derived from serum of patients with rare earth pneumoconiosis by RNA-sequencing and PI3K/Akt pathway is activated in lung of mice exposed to rare earth Nd2O3.,2025,10.1016/j.toxlet.2025.01.001,https://pubmed.ncbi.nlm.nih.gov/39756494/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,39701680,[Molecular mechanism of Xiangsha Liujunzi Decoction in treating chronic atrophic gastritis based on transcriptome sequencing technology].,2024,10.19540/j.cnki.cjcmm.20240509.401,https://pubmed.ncbi.nlm.nih.gov/39701680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,38473810,Transcriptomic Analysis Reveals Intrinsic Abnormalities in Endometrial Polyps.,2024,10.3390/ijms25052557,https://pubmed.ncbi.nlm.nih.gov/38473810/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,34026626,Long Noncoding RNA KCNMB2-AS1 Promotes SMAD5 by Targeting miR-3194-3p to Induce Bladder Cancer Progression.,2021,10.3389/fonc.2021.649778,https://pubmed.ncbi.nlm.nih.gov/34026626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,37372391,Genome-Wide Assessment of Runs of Homozygosity by Whole-Genome Sequencing in Diverse Horse Breeds Worldwide.,2023,10.3390/genes14061211,https://pubmed.ncbi.nlm.nih.gov/37372391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,36203817,"Effect of an autism-associated KCNMB2 variant, G124R, on BK channel properties.",2022,10.1016/j.crphys.2022.09.001,https://pubmed.ncbi.nlm.nih.gov/36203817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,34367236,KCNMB2-AS1 Promotes Bladder Cancer Progression Through Sponging miR-374a-3p to Upregulate S100A10.,2021,10.3389/fgene.2021.655569,https://pubmed.ncbi.nlm.nih.gov/34367236/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,35979065,Long Noncoding RNA KCNMB2-AS1 Increases ROCK1 Expression by Sponging microRNA-374a-3p to Facilitate the Progression of Non-Small-Cell Lung Cancer [Retraction].,2022,10.2147/cmar.s385608,https://pubmed.ncbi.nlm.nih.gov/35979065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,33335424,Long Noncoding RNA KCNMB2-AS1 Increases ROCK1 Expression by Sponging microRNA-374a-3p to Facilitate the Progression of Non-Small-Cell Lung Cancer.,2020,10.2147/cmar.s270646,https://pubmed.ncbi.nlm.nih.gov/33335424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,34526147,"Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study.",2021,10.1186/s40478-021-01250-2,https://pubmed.ncbi.nlm.nih.gov/34526147/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,33028109,Long Noncoding RNA KCNMB2-AS1 Stabilized by N6-Methyladenosine Modification Promotes Cervical Cancer Growth Through Acting as a Competing Endogenous RNA.,2020,10.1177/0963689720964382,https://pubmed.ncbi.nlm.nih.gov/33028109/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,34707415,Long Noncoding RNA KCNMB2-AS1 Increases ROCK1 Expression by Sponging microRNA-374a-3p to Facilitate the Progression of Non-Small-Cell Lung Cancer [Expression of Concern].,2021,10.2147/cmar.s344580,https://pubmed.ncbi.nlm.nih.gov/34707415/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,32371615,Effects of KCNMB2 gene polymorphisms on ritodrine therapy outcomes in women with preterm labor.,2020,10.1097/fpc.0000000000000404,https://pubmed.ncbi.nlm.nih.gov/32371615/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,28373690,A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice.,2018,10.1038/mp.2017.53,https://pubmed.ncbi.nlm.nih.gov/28373690/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,35909518,Bioinformatics Analysis of the Mechanisms of Diabetic Nephropathy via Novel Biomarkers and Competing Endogenous RNA Network.,2022,10.3389/fendo.2022.934022,https://pubmed.ncbi.nlm.nih.gov/35909518/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,28131462,"Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2.",2017,10.1016/j.neurobiolaging.2017.01.003,https://pubmed.ncbi.nlm.nih.gov/28131462/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,27003218,"Hippocampal Sclerosis of Aging, a Common Alzheimer's Disease 'Mimic': Risk Genotypes are Associated with Brain Atrophy Outside the Temporal Lobe.",2016,10.3233/jad-160077,https://pubmed.ncbi.nlm.nih.gov/27003218/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,23826284,Polyunsaturated Fatty Acids Modulate the Association between PIK3CA-KCNMB3 Genetic Variants and Insulin Resistance.,2013,10.1371/journal.pone.0067394,https://pubmed.ncbi.nlm.nih.gov/23826284/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,28189700,CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.,2017,10.1016/j.exger.2017.01.025,https://pubmed.ncbi.nlm.nih.gov/28189700/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,30819905,Complications of whole-exome sequencing for causal gene discovery in primary platelet secretion defects.,2019,10.3324/haematol.2018.204990,https://pubmed.ncbi.nlm.nih.gov/30819905/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,24414257,"IFN-γ-mediated reduction of large-conductance, Ca2+-activated, voltage-dependent K+ (BK) channel activity in airway epithelial cells leads to mucociliary dysfunction.",2014,10.1152/ajplung.00247.2013,https://pubmed.ncbi.nlm.nih.gov/24414257/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,10766764,Cloning and functional expression of two families of beta-subunits of the large conductance calcium-activated K+ channel.,2000,10.1074/jbc.m910187199,https://pubmed.ncbi.nlm.nih.gov/10766764/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,10692449,"Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4.",2000,10.1074/jbc.275.9.6453,https://pubmed.ncbi.nlm.nih.gov/10692449/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNMB3,ENSG00000171121,Unsafe,10585773,Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2.,1999,10.1006/geno.1999.5975,https://pubmed.ncbi.nlm.nih.gov/10585773/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,42773706,Pre-clinical validation of AAV gene therapy for KCNV2 retinopathy improves visual function and expression in mouse and patient models.,2026,10.1016/j.ymthe.2026.09.025,https://pubmed.ncbi.nlm.nih.gov/42773706/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,42653690,Targeted Sequencing and Haplotype Analysis of Voltage-Gated Potassium Channel Genes Reveal a Potential Association of &lt;i&gt;KCNV2&lt;/i&gt; Haplotypes with Antiseizure Medication Response in Turkish Patients with Epilepsy.,2026,10.3390/ph19081193,https://pubmed.ncbi.nlm.nih.gov/42653690/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,41516321,&lt;i&gt;KCNV2&lt;/i&gt;-Deficient Retinal Organoid Model of Cone Dystrophy-In Vitro Screening for AAV Gene Replacement Therapy.,2025,10.3390/ijms27010449,https://pubmed.ncbi.nlm.nih.gov/41516321/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,41447038,Retinal Sensitivity Loss and Beyond in &lt;i&gt;KCNV2&lt;/i&gt;-Related Retinopathy: The First Genetically Confirmed Case in Türkiye.,2025,10.4274/tjo.galenos.2025.03491,https://pubmed.ncbi.nlm.nih.gov/41447038/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,42106701,Electronegative electroretinography in inherited retinal disease: a systematic review of genotype-phenotype correlations.,2026,10.1186/s12886-026-04858-x,https://pubmed.ncbi.nlm.nih.gov/42106701/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,39200733,Novel and Previously Known Mutations of the KCNV2 Gene Cause Various Variants of the Clinical Course of Cone Dystrophy with Supernormal Rod Response in Children.,2024,10.3390/jcm13164592,https://pubmed.ncbi.nlm.nih.gov/39200733/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,41902434,Loss of Kv8.2 in the Mouse Retina Is Associated With Altered One-Carbon Metabolism.,2026,10.1111/jnc.70420,https://pubmed.ncbi.nlm.nih.gov/41902434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,38454848,Structural and functional characterization of an individual with the M285R &lt;i&gt;KCNV2&lt;/i&gt; hypomorphic allele.,2024,10.1080/13816810.2024.2324046,https://pubmed.ncbi.nlm.nih.gov/38454848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,39083856,Establishment of a human induced pluripotent stem cell line (ABi004-A) carrying a compound heterozygous mutation in the KCNV2 gene.,2024,10.1016/j.scr.2024.103512,https://pubmed.ncbi.nlm.nih.gov/39083856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,39792073,Retinal Sensitivity in KCNV2-Associated Retinopathy.,2025,10.1167/iovs.66.1.26,https://pubmed.ncbi.nlm.nih.gov/39792073/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,37852740,&lt;i&gt;KCNV2&lt;/i&gt;-associated retinopathy: genotype-phenotype correlations - &lt;i&gt;KCNV2&lt;/i&gt; study group report 3.,2024,10.1136/bjo-2023-323640,https://pubmed.ncbi.nlm.nih.gov/37852740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,40423692,A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers.,2025,10.7554/elife.99410,https://pubmed.ncbi.nlm.nih.gov/40423692/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,38443311,Natural history and biomarkers of KCNV2-associated retinopathy.,2024,10.1111/ceo.14373,https://pubmed.ncbi.nlm.nih.gov/38443311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,34535971,Compound heterozygous KCNV2 variants contribute to cone dystrophy with supernormal rod responses in a Chinese family.,2021,10.1002/mgg3.1795,https://pubmed.ncbi.nlm.nih.gov/34535971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,40327004,Distance From the Foveal Center: A Method for the Calculation of Eccentric Fixation.,2025,10.1167/tvst.14.5.9,https://pubmed.ncbi.nlm.nih.gov/40327004/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,33309813,"KCNV2-Associated Retinopathy: Genetics, Electrophysiology, and Clinical Course-KCNV2 Study Group Report 1.",2021,10.1016/j.ajo.2020.11.022,https://pubmed.ncbi.nlm.nih.gov/33309813/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,34641523,Detection of Circulating Serum microRNA/Protein Complexes in ASD Using Functionalized Chips for an Atomic Force Microscope.,2021,10.3390/molecules26195979,https://pubmed.ncbi.nlm.nih.gov/34641523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,32441199,"KCNV2 retinopathy: clinical features, molecular genetics and directions for future therapy.",2020,10.1080/13816810.2020.1766087,https://pubmed.ncbi.nlm.nih.gov/32441199/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,33960280,A novel KCNV2 mutation in a patient taking hydroxychloroquine associated with cone dystrophy with supernormal rod response.,2021,10.1080/13816810.2021.1920039,https://pubmed.ncbi.nlm.nih.gov/33960280/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,33738644,Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report.,2021,10.1007/s10633-021-09828-w,https://pubmed.ncbi.nlm.nih.gov/33738644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,37460904,"Fundus autofluorescence, optical coherence tomography and electroretinography abnormalities in a patient with digoxin retinopathy that resemble those in KCNV2-associated retinopathy.",2023,10.1007/s10633-023-09942-x,https://pubmed.ncbi.nlm.nih.gov/37460904/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,33737031,KCNV2-Associated Retinopathy: Detailed Retinal Phenotype and Structural Endpoints-KCNV2 Study Group Report 2.,2021,10.1016/j.ajo.2021.03.004,https://pubmed.ncbi.nlm.nih.gov/33737031/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,37889708,Genome-Wide Re-Sequencing Data Reveals the Population Structure and Selection Signatures of Tunchang Pigs in China.,2023,10.3390/ani13111835,https://pubmed.ncbi.nlm.nih.gov/37889708/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,30441785,The Impact of Potassium Channel Gene Polymorphisms on Antiepileptic Drug Responsiveness in Arab Patients with Epilepsy.,2018,10.3390/jpm8040037,https://pubmed.ncbi.nlm.nih.gov/30441785/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,30927187,Two-color pupillometry in KCNV2 retinopathy.,2019,10.1007/s10633-019-09691-w,https://pubmed.ncbi.nlm.nih.gov/30927187/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,31405227,"Association between SNPs of Circulating Vascular Endothelial Growth Factor Levels, Hypercholesterolemia and Metabolic Syndrome.",2019,10.3390/medicina55080464,https://pubmed.ncbi.nlm.nih.gov/31405227/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,34063002,"Molecular, Cellular and Functional Changes in the Retinas of Young Adult Mice Lacking the Voltage-Gated K+ Channel Subunits Kv8.2 and K2.1.",2021,10.3390/ijms22094877,https://pubmed.ncbi.nlm.nih.gov/34063002/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,28765276,Vascular Endothelial Growth Factor and Ischemic Heart Disease Risk: A Mendelian Randomization Study.,2017,10.1161/jaha.117.005619,https://pubmed.ncbi.nlm.nih.gov/28765276/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,23440187,Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome.,2013,10.1073/pnas.1217154110,https://pubmed.ncbi.nlm.nih.gov/23440187/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCNV2,ENSG00000168263,Unsafe,12060745,Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome.,2002,10.1073/pnas.122617999,https://pubmed.ncbi.nlm.nih.gov/12060745/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCTD19,ENSG00000168676,Unsafe,41221840,Identification of a Homozygous Nonsense Variant in KCTD19 Causing Meiotic Arrest and Non-Obstructive Azoospermia in Humans.,2026,10.1111/cge.70106,https://pubmed.ncbi.nlm.nih.gov/41221840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCTD19,ENSG00000168676,Unsafe,37921559,ZFP541 and KCTD19 regulate chromatin organization and transcription programs for male meiotic progression.,2024,10.1111/cpr.13567,https://pubmed.ncbi.nlm.nih.gov/37921559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCTD19,ENSG00000168676,Unsafe,38253538,Molecular quantitative trait loci in reproductive tissues impact male fertility in cattle.,2024,10.1038/s41467-024-44935-7,https://pubmed.ncbi.nlm.nih.gov/38253538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCTD19,ENSG00000168676,Unsafe,37485353,Loss-of-function variants in KCTD19 cause non-obstructive azoospermia in humans.,2023,10.1016/j.isci.2023.107193,https://pubmed.ncbi.nlm.nih.gov/37485353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCTD19,ENSG00000168676,Unsafe,40783914,[Immunological mechanism of non-obstructive azoospermia: An exploration based on bioinformatics and machine learning].,2024,,https://pubmed.ncbi.nlm.nih.gov/40783914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCTD19,ENSG00000168676,Unsafe,39318590,Compound heterozygous &lt;i&gt;KCTD19&lt;/i&gt; variants in a man with isolated nonobstructive azoospermia.,2024,10.1002/rmb2.12608,https://pubmed.ncbi.nlm.nih.gov/39318590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCTD19,ENSG00000168676,Unsafe,41074104,Saliva as a potential and non-invasive approach to identify upregulated genes associated with comorbidities of T1DM: a brief report.,2025,10.1186/s40001-025-03105-1,https://pubmed.ncbi.nlm.nih.gov/41074104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCTD19,ENSG00000168676,Unsafe,33961623,KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice.,2021,10.1371/journal.pgen.1009412,https://pubmed.ncbi.nlm.nih.gov/33961623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCTD19,ENSG00000168676,Unsafe,34075040,Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis.,2021,10.1038/s41467-021-23378-4,https://pubmed.ncbi.nlm.nih.gov/34075040/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCTD19,ENSG00000168676,Unsafe,37192818,Biallelic variants in KCTD19 associated with male factor infertility and oligoasthenoteratozoospermia.,2023,10.1093/humrep/dead095,https://pubmed.ncbi.nlm.nih.gov/37192818/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCTD19,ENSG00000168676,Unsafe,36845001,Evaluation of the efficacy of creatine chemical exchange saturation transfer imaging in assessing testicular maturity.,2023,10.1002/rmb2.12507,https://pubmed.ncbi.nlm.nih.gov/36845001/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCTD19,ENSG00000168676,Unsafe,35341968,The ZFP541-KCTD19 complex is essential for pachytene progression by activating meiotic genes during mouse spermatogenesis.,2022,10.1016/j.jgg.2022.03.005,https://pubmed.ncbi.nlm.nih.gov/35341968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCTD19,ENSG00000168676,Unsafe,33257503,Prediction and Validation of Mouse Meiosis-Essential Genes Based on Spermatogenesis Proteome Dynamics.,2021,10.1074/mcp.ra120.002081,https://pubmed.ncbi.nlm.nih.gov/33257503/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCTD19,ENSG00000168676,Unsafe,35222524,Prognostic Model of Eleven Genes Based on the Immune Microenvironment in Patients With Thymoma.,2022,10.3389/fgene.2022.668696,https://pubmed.ncbi.nlm.nih.gov/35222524/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCTD19,ENSG00000168676,Unsafe,26350515,Novel genetic causes for cerebral visual impairment.,2016,10.1038/ejhg.2015.186,https://pubmed.ncbi.nlm.nih.gov/26350515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KCTD19,ENSG00000168676,Unsafe,26466362,A Genome-Wide Screen for Machinery Involved in Downregulation of MHC Class I by HIV-1 Nef.,2015,10.1371/journal.pone.0140404,https://pubmed.ncbi.nlm.nih.gov/26466362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,41680357,Rare KDM4C variants and reduced expression underlie epigenetic dysregulation in rheumatoid arthritis.,2026,10.1007/s12026-026-09751-9,https://pubmed.ncbi.nlm.nih.gov/41680357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,42579361,KDM4C inhibition reinforces NK cell cytotoxicity through the cGAS-STING pathway in TP53-mutated AML.,2026,10.14336/ad.2026.0432,https://pubmed.ncbi.nlm.nih.gov/42579361/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,41490602,The Lysine Demethylase KDM4C Is an Oncogenic Driver and Regulates ERK Activity in KRAS-Mutant Pancreatic Ductal Adenocarcinoma.,2026,10.1158/2767-9764.crc-25-0278,https://pubmed.ncbi.nlm.nih.gov/41490602/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,41661469,Mechanism of FOXP2 in the Hepatocellular Carcinoma Progression via Ferroptosis Through RBM15B-Mediated m6A Modification.,2026,10.1007/s12010-025-05554-0,https://pubmed.ncbi.nlm.nih.gov/41661469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,41217736,Histone demethylase KDM4C confers temozolomide resistance to glioblastoma cells by epigenetically regulating E2F6.,2025,10.1007/s12272-025-01580-y,https://pubmed.ncbi.nlm.nih.gov/41217736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,40635012,Mutation of the histone demethylase Gasc1 causes ASD-like symptoms in mice.,2025,10.1186/s41232-025-00374-5,https://pubmed.ncbi.nlm.nih.gov/40635012/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,40280301,Targeted inhibition of JMJD2C/MALAT1 axis compensates for the deficiency of metformin in reversing ovarian cancer platinum resistance.,2025,10.1016/j.lfs.2025.123663,https://pubmed.ncbi.nlm.nih.gov/40280301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,40711862,Impact of KDM4C on the radiosensitivity of glioblastoma cells.,2025,10.1080/09553002.2025.2534999,https://pubmed.ncbi.nlm.nih.gov/40711862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,40424935,USP35 promotes hepatocellular carcinoma proliferation through GASC1-mediated ROCK2 upregulation.,2025,10.1016/j.tranon.2025.102430,https://pubmed.ncbi.nlm.nih.gov/40424935/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,42432681,8-gingerol from Zingiber officinale induces ER stress-mediated ferroptosis and apoptosis in ovarian cancer involving TRPV1 activation.,2026,10.1186/s12964-026-03014-8,https://pubmed.ncbi.nlm.nih.gov/42432681/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,40457074,KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage.,2025,10.1038/s41588-025-02197-z,https://pubmed.ncbi.nlm.nih.gov/40457074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,40259045,KDM4C works in concert with GATA1 to regulate heme metabolism in head and neck squamous cell carcinoma.,2025,10.1007/s00018-025-05693-x,https://pubmed.ncbi.nlm.nih.gov/40259045/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,40975760,Fumarate activates the IL-6/JAK/STAT3 pathway by inhibiting KDM4C-mediated H3K36me3 demethylation in FH-knockdown renal cancer cells.,2025,10.1038/s41416-025-03195-y,https://pubmed.ncbi.nlm.nih.gov/40975760/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,41505486,Targeting epigenetic regulators: In-silico discovery of natural inhibitors against histone demethylase KDM4C.,2026,10.1371/journal.pone.0340107,https://pubmed.ncbi.nlm.nih.gov/41505486/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,42794600,Peripheral Blood Transcriptomic Profile Associated with Cutaneous Radiation Injury in Cancer Patients Undergoing Radiotherapy.,2026,10.3390/ijms27188168,https://pubmed.ncbi.nlm.nih.gov/42794600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,40716534,KDM4C regulates trophoblast proliferation and migration in preeclampsia via the NFATc4/Wnt pathway.,2025,10.1016/j.ijbiomac.2025.146320,https://pubmed.ncbi.nlm.nih.gov/40716534/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,39285693,A convenient research strategy for functional verification of epigenetic regulators during spermatogenesis.,2025,10.4103/aja202453,https://pubmed.ncbi.nlm.nih.gov/39285693/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,42792941,The Inhibition of Histone Lysine Demethylases Affects Head and Neck Cancer Cell Growth and Response to Cisplatin.,2026,10.3390/genes17091047,https://pubmed.ncbi.nlm.nih.gov/42792941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,38975736,Jmjd2c maintains the ALDH&lt;sup&gt;bri+&lt;/sup&gt; cancer stemness with transcription factor SOX2 in lung squamous cell carcinoma.,2024,10.1080/15384047.2024.2373447,https://pubmed.ncbi.nlm.nih.gov/38975736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,41192807,BACH1 drives ferroptosis in lung ischemia-reperfusion injury through epigenetic suppression of STAT3-Mediated antioxidant defense.,2026,10.1016/j.abb.2025.110669,https://pubmed.ncbi.nlm.nih.gov/41192807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,41635813,Spotlights on ubiquitin-specific proteases in lung cancer: from multifaceted pathophysiological mechanisms to potential therapeutic targets.,2026,10.7717/peerj.20702,https://pubmed.ncbi.nlm.nih.gov/41635813/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,39807336,Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer.,2024,10.1016/j.apsb.2024.07.018,https://pubmed.ncbi.nlm.nih.gov/39807336/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,35121645,Targeting KDM4C enhances CD8+ T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer.,2022,10.1136/jitc-2021-003716,https://pubmed.ncbi.nlm.nih.gov/35121645/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,38252669,"The promotive role of lncRNA MIR205HG in proliferation, invasion, and migration of melanoma cells via the JMJD2C/ALKBH5 axis.",2024,10.1371/journal.pone.0290986,https://pubmed.ncbi.nlm.nih.gov/38252669/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,36709354,The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2V617F mutated cells.,2023,10.1038/s41375-023-01826-y,https://pubmed.ncbi.nlm.nih.gov/36709354/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,38684915,Glutamine-mediated epigenetic regulation of cFLIP underlies resistance to TRAIL in pancreatic cancer.,2024,10.1038/s12276-024-01231-0,https://pubmed.ncbi.nlm.nih.gov/38684915/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,35522148,Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas.,2023,10.3324/haematol.2021.280005,https://pubmed.ncbi.nlm.nih.gov/35522148/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,33469678,JMJD2C triggers the growth of multiple myeloma cells via activation of β‑catenin.,2021,10.3892/or.2021.7934,https://pubmed.ncbi.nlm.nih.gov/33469678/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,39824883,Cross-trait multivariate GWAS confirms health implications of pubertal timing.,2025,10.1038/s41467-025-56191-4,https://pubmed.ncbi.nlm.nih.gov/39824883/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,32411232,GASC1-Adapted Neoadjuvant Chemotherapy for Resectable Esophageal Squamous Cell Carcinoma: A Prospective Clinical Biomarker Trial.,2020,10.1155/2020/1607860,https://pubmed.ncbi.nlm.nih.gov/32411232/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4C,ENSG00000107077,Unsafe,10987278,"Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines.",2000,,https://pubmed.ncbi.nlm.nih.gov/10987278/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,42876627,Histone demethylase JMJD2D promotes macrophage IL-12b expression and contributes to host defense against &lt;i&gt;Listeria monocytogenes&lt;/i&gt; infection.,2026,10.3389/fcimb.2026.1901735,https://pubmed.ncbi.nlm.nih.gov/42876627/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,42325777,KDM4D enhances radiosensitivity in esophageal squamous cell carcinoma through the SRBD1/RPL11/c-Myc/WIP1/CHK1 axis.,2026,10.62347/gwrn1389,https://pubmed.ncbi.nlm.nih.gov/42325777/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,40504421,Histone demethylase JMJD2D emerges as a novel prognostic biomarker and exhibits correlation with immune infiltration in lung adenocarcinoma.,2025,10.1007/s12672-025-02871-y,https://pubmed.ncbi.nlm.nih.gov/40504421/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,42685882,Histone demethylase JMJD2D promotes lung cancer progression by activating Wnt/β-catenin signaling.,2026,10.1016/j.cellsig.2026.112858,https://pubmed.ncbi.nlm.nih.gov/42685882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,42072725,Histone Demethylase JMJD2D Suppresses Influenza A Virus Infection by Promoting RIG-I Expression.,2026,10.3390/biom16040604,https://pubmed.ncbi.nlm.nih.gov/42072725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,42048749,Kdm4dl is expressed in adult mouse testis and encodes a functional KDM4D-like protein.,2026,10.1016/j.bbrc.2026.153765,https://pubmed.ncbi.nlm.nih.gov/42048749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,41546606,KDM4D-RPS5 Complex Promoted Osteo/Dentinogenic Differentiation of DPSCs via CNR1-Maintained Mitochondrial Functional Homeostasis.,2026,10.1111/iej.70102,https://pubmed.ncbi.nlm.nih.gov/41546606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,42195053,Host Gene Signatures Associated with Gastric Cancer-Associated Microbial Taxa: A Descriptive Microbiome-Transcriptome Study.,2026,10.3390/medicina62050799,https://pubmed.ncbi.nlm.nih.gov/42195053/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,39034148,Kdm4d mutant mice show impaired sperm motility and subfertility.,2024,10.1262/jrd.2024-039,https://pubmed.ncbi.nlm.nih.gov/39034148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,38905308,Histone demethylase JMJD2D protects against enteric bacterial infection via up-regulating colonic IL-17F to induce β-defensin expression.,2024,10.1371/journal.ppat.1012316,https://pubmed.ncbi.nlm.nih.gov/38905308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,40325472,Moxibustion regulates KDM4D expression and modulates lipid metabolism to inhibit tumor proliferation in CAC mice.,2025,10.1186/s12935-025-03798-8,https://pubmed.ncbi.nlm.nih.gov/40325472/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,40843439,Investigating the N-terminal linker histone H1 subtypes as substrates for JmjC lysine demethylases.,2025,10.1039/d5cb00083a,https://pubmed.ncbi.nlm.nih.gov/40843439/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,37275914,Control of enhancer and promoter activation in the type I interferon response by the histone demethylase Kdm4d/JMJD2d.,2023,10.3389/fimmu.2023.1146699,https://pubmed.ncbi.nlm.nih.gov/37275914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,35740507,Histone Demethylase JMJD2D: A Novel Player in Colorectal and Hepatocellular Cancers.,2022,10.3390/cancers14122841,https://pubmed.ncbi.nlm.nih.gov/35740507/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,41237778,Derivation of embryonic stem cells from cloned blastocysts using improved somatic cell nuclear transfer in common marmosets.,2025,10.1016/j.stemcr.2025.102710,https://pubmed.ncbi.nlm.nih.gov/41237778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,40715324,Hepatocyte reporter cells and integrated metabolomic and transcriptomic analyses reveal insights into hepatocyte changes in offspring of pregnancies with obesity.,2025,10.1038/s41598-025-10808-2,https://pubmed.ncbi.nlm.nih.gov/40715324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,40624981,Efficient Somatic Cell Nuclear Transfer by Overcoming Both Pre- and Post-Implantation Epigenetic Barriers.,2025,10.1002/advs.202504669,https://pubmed.ncbi.nlm.nih.gov/40624981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,37701334,JMJD2D stabilises and cooperates with HBx protein to promote HBV transcription and replication.,2023,10.1016/j.jhepr.2023.100849,https://pubmed.ncbi.nlm.nih.gov/37701334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,39158700,Iron-dependent KDM4D activity controls the quiescence-activity balance of MSCs via the PI3K-Akt-Foxo1 pathway.,2024,10.1007/s00018-024-05376-z,https://pubmed.ncbi.nlm.nih.gov/39158700/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,38045004,Methylation of the epigenetic JMJD2D protein by SET7/9 promotes prostate tumorigenesis.,2023,10.3389/fonc.2023.1295613,https://pubmed.ncbi.nlm.nih.gov/38045004/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,40088847,USP14 inhibits sensitization-mediated degradation of KDM4D to epigenetically regulate dendritic cell tolerogenic capacity and mitigates airway allergy.,2025,10.1016/j.cellimm.2025.104943,https://pubmed.ncbi.nlm.nih.gov/40088847/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,41762076,A Dual-Key Gated Nuclear-DNA-Targeted Photogenerator for Amplified Photodynamic Immunotherapy of Breast Cancer.,2026,10.1002/anie.202523661,https://pubmed.ncbi.nlm.nih.gov/41762076/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,42371179,Integrated structure-based and fragment-guided design of isonicotinic acid derivatives as potential KDM4A inhibitors: an in silico study.,2026,10.1007/s10822-026-00865-8,https://pubmed.ncbi.nlm.nih.gov/42371179/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,38123979,Targeting MMP9 in CTNNB1 mutant hepatocellular carcinoma restores CD8+ T cell-mediated antitumour immunity and improves anti-PD-1 efficacy.,2024,10.1136/gutjnl-2023-331342,https://pubmed.ncbi.nlm.nih.gov/38123979/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,40395727,Plant polysaccharides influence tumor development based on epigenetics: a review.,2025,10.3389/fphar.2025.1588857,https://pubmed.ncbi.nlm.nih.gov/40395727/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,35027670,Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling.,2022,10.1038/s41388-021-02173-x,https://pubmed.ncbi.nlm.nih.gov/35027670/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,40609216,From mechanism to therapy: How EIPA modulates dendritic cell-mediated allergic responses via IL-12b and TIM4.,2025,10.1016/j.biopha.2025.118285,https://pubmed.ncbi.nlm.nih.gov/40609216/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,33434575,Histone demethylase JMJD2D promotes the self-renewal of liver cancer stem-like cells by enhancing EpCAM and Sox9 expression.,2021,10.1074/jbc.ra120.015335,https://pubmed.ncbi.nlm.nih.gov/33434575/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,37626981,Lysine-Specific Demethylase 4D Is Critical for the Regulation of the Cell Cycle and Antioxidant Capacity in Goat Fibroblast Cells.,2023,10.3390/biology12081095,https://pubmed.ncbi.nlm.nih.gov/37626981/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,36817590,Dieting reverses histone methylation and hypothalamic AgRP regulation in obese rats.,2023,10.3389/fendo.2023.1121829,https://pubmed.ncbi.nlm.nih.gov/36817590/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,34820329,Epigenetic Regulator KDM4D Restricts Tumorigenesis via Modulating SYVN1/HMGB1 Ubiquitination Axis in Esophageal Squamous Cell Carcinoma.,2021,10.3389/fonc.2021.761346,https://pubmed.ncbi.nlm.nih.gov/34820329/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,35145029,TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation.,2022,10.1073/pnas.2113454119,https://pubmed.ncbi.nlm.nih.gov/35145029/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,34732786,The chemotherapeutic drug carboplatin affects macrophage responses to LPS and LPS tolerance via epigenetic modifications.,2021,10.1038/s41598-021-00955-7,https://pubmed.ncbi.nlm.nih.gov/34732786/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,29766333,Treatment of donor cells with recombinant KDM4D protein improves preimplantation development of cloned ovine embryos.,2018,10.1007/s10616-018-0224-6,https://pubmed.ncbi.nlm.nih.gov/29766333/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM4D,ENSG00000186280,Unsafe,32892084,"A UHPLC-MS/MS method for the quantification of JIB-04 in rat plasma: Development, validation and application to pharmacokinetics study.",2020,10.1016/j.jpba.2020.113587,https://pubmed.ncbi.nlm.nih.gov/32892084/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,42858778,Neuronal activity-regulated histone demethylase KDM7A controls hippocampal gene expression and behavior.,2026,10.1016/j.pneurobio.2026.102957,https://pubmed.ncbi.nlm.nih.gov/42858778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,41578150,Histone demethylase KDM7A negatively regulates fibrotic macrophage polarization and lung fibrosis progression.,2026,10.1038/s42003-026-09610-1,https://pubmed.ncbi.nlm.nih.gov/41578150/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,41870972,KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer.,2026,10.1002/1878-0261.70238,https://pubmed.ncbi.nlm.nih.gov/41870972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,37909656,"Kdm7a expression is spatiotemporally regulated in developing Xenopus laevis embryos, and its overexpression influences late retinal development.",2024,10.1002/dvdy.670,https://pubmed.ncbi.nlm.nih.gov/37909656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,39836528,The Histone Lysine Demethylase KDM7A Contributes to Reward Memory via Fscn1-Induced Synaptic Plasticity in the Medial Prefrontal Cortex.,2025,10.1002/advs.202405352,https://pubmed.ncbi.nlm.nih.gov/39836528/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,41296141,JHDM1D-AS1 Facilitates Progression of Colorectal Cancer via the miR-193b-3p/HPRT1 Axis.,2026,10.1007/s10528-025-11298-7,https://pubmed.ncbi.nlm.nih.gov/41296141/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,39136575,Combined expression of JHDM1D/KDM7A gene and long non-coding RNA RP11-363E7.4 as a biomarker for urothelial cancer prognosis.,2024,10.1590/1678-4685-gmb-2023-0265,https://pubmed.ncbi.nlm.nih.gov/39136575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,37751140,"KDM7 Demethylases: Regulation, Function and Therapeutic Targeting.",2023,10.1007/978-3-031-38176-8_8,https://pubmed.ncbi.nlm.nih.gov/37751140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,41028082,Lapachol interferes with the cell cycle and inhibits proliferation and migration of bladder tumor cells with effects on ncRNA expression.,2025,10.1038/s41598-025-04432-3,https://pubmed.ncbi.nlm.nih.gov/41028082/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,38756663,"KDM7A-DT induces genotoxic stress, tumorigenesis, and progression of p53 missense mutation-associated invasive breast cancer.",2024,10.3389/fonc.2024.1227151,https://pubmed.ncbi.nlm.nih.gov/38756663/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,40671466,"Beta-Lapachone: Effects on Proliferation, Survival, Migration, Cell Cycle, and lncRNA Modulation in Bladder Cancer Cells With Distinct TP53 Profiles.",2025,10.1002/ddr.70128,https://pubmed.ncbi.nlm.nih.gov/40671466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,42449712,Overcoming Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma (HNSCC): The Role of Histone Methyltransferase and Demethylase Inhibitors.,2026,10.3390/cancers18132170,https://pubmed.ncbi.nlm.nih.gov/42449712/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,39765675,Epigenetic Modifiers: Exploring the Roles of Histone Methyltransferases and Demethylases in Cancer and Neurodegeneration.,2024,10.3390/biology13121008,https://pubmed.ncbi.nlm.nih.gov/39765675/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,41155336,Kdm7aa Orchestrates an Immunomodulatory Cardiomyocyte Program to Enable Zebrafish Heart Regeneration.,2025,10.3390/ijms262010044,https://pubmed.ncbi.nlm.nih.gov/41155336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,41000061,Antiproliferative Effects of the Triterpene Ursolic Acid Natural Product in Bladder and Ovarian Tumor Cell Lines.,2025,10.1002/ddr.70172,https://pubmed.ncbi.nlm.nih.gov/41000061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,38943031,Nuclear miR-451a activates KDM7A and leads to cetuximab resistance in head and neck squamous cell carcinoma.,2024,10.1007/s00018-024-05324-x,https://pubmed.ncbi.nlm.nih.gov/38943031/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,37565374,The Lysine Demethylase KDM7A Regulates Immediate Early Genes in Neurons.,2023,10.1002/advs.202301367,https://pubmed.ncbi.nlm.nih.gov/37565374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,39509788,Structure-Based identification of a potent KDM7A inhibitor exerts anticancer activity through transcriptionally reducing MKRN1 in taxol- resistant and -sensitive triple-negative breast cancer cells.,2024,10.1016/j.bioorg.2024.107945,https://pubmed.ncbi.nlm.nih.gov/39509788/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,38346941,Histone demethylase KDM7A regulates bone homeostasis through balancing osteoblast and osteoclast differentiation.,2024,10.1038/s41419-024-06521-z,https://pubmed.ncbi.nlm.nih.gov/38346941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,34249916,The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells.,2021,10.3389/fcell.2021.664375,https://pubmed.ncbi.nlm.nih.gov/34249916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,42798758,An atfs-1 loss-of-function screen identifies novel regulators of α-synuclein toxicity in C. elegans dopaminergic neurons.,2026,10.1093/g3journal/jkag273,https://pubmed.ncbi.nlm.nih.gov/42798758/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,41882721,Pharmacogenomic study of the effects of saxagliptin on glucose control and hypoglycemic events.,2026,10.1186/s12920-026-02348-z,https://pubmed.ncbi.nlm.nih.gov/41882721/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,37416723,Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function.,2023,10.1039/d2sc05944d,https://pubmed.ncbi.nlm.nih.gov/37416723/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,37696455,Lysine-specific demethylase 7A (KDM7A): A potential target for disease therapy.,2023,10.1016/j.bcp.2023.115799,https://pubmed.ncbi.nlm.nih.gov/37696455/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,41130303,Dual roles of Makorin ring finger protein 1 in ubiquitination and RNA biology: regulatory mechanisms and therapeutic implications in human diseases.,2026,10.1016/j.bcp.2025.117441,https://pubmed.ncbi.nlm.nih.gov/41130303/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,36903656,LncRNA JHDM1D-AS1 Is a Key Biomarker for Progression and Modulation of Gemcitabine Sensitivity in Bladder Cancer Cells.,2023,10.3390/molecules28052412,https://pubmed.ncbi.nlm.nih.gov/36903656/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,37623314,The dual functions of KDM7A in HBV replication and immune microenvironment.,2023,10.1128/spectrum.01641-23,https://pubmed.ncbi.nlm.nih.gov/37623314/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,35095995,Whole Blood Transcriptome Analysis in Children with Sickle Cell Anemia.,2021,10.3389/fgene.2021.737741,https://pubmed.ncbi.nlm.nih.gov/35095995/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,34484645,An Integrated Bioinformatics Analysis of the Potential Regulatory Effects of miR-21 on T-cell Related Target Genes in Multiple Sclerosis.,2021,10.18502/ajmb.v13i3.6364,https://pubmed.ncbi.nlm.nih.gov/34484645/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,32125007,Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells.,2020,10.15252/embj.2019103949,https://pubmed.ncbi.nlm.nih.gov/32125007/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,39504828,Identification of SNPs and INDELS associated with duck egg quality traits through a genome-wide association analysis.,2024,10.1016/j.psj.2024.104459,https://pubmed.ncbi.nlm.nih.gov/39504828/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KDM7A,ENSG00000006459,Unsafe,36227664,Expression of CD123 Related Long Non-coding RNA in Acute Myeloid Leukemia Bone Marrow Mononuclear Cells and Its Clinical Significance.,2022,10.14715/cmb/2022.68.6.23,https://pubmed.ncbi.nlm.nih.gov/36227664/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDC1,ENSG00000135314,Unsafe,36734243,Upregulation of KHDC1L promotes the proliferation and inhibits apoptosis in head and neck squamous cell carcinoma.,2023,10.1080/15592294.2023.2175168,https://pubmed.ncbi.nlm.nih.gov/36734243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDC1,ENSG00000135314,Unsafe,35441736,Differential expression and analysis of extrachromosomal circular DNAs as serum biomarkers in lung adenocarcinoma.,2022,10.1002/jcla.24425,https://pubmed.ncbi.nlm.nih.gov/35441736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDC1,ENSG00000135314,Unsafe,33162025,Five multicopy gene family genes expressed during the maternal-to-zygotic transition are not essential for mouse development.,2021,10.1016/j.bbrc.2020.11.004,https://pubmed.ncbi.nlm.nih.gov/33162025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDC1,ENSG00000135314,Unsafe,22731819,"KHDC1A, a novel translational repressor, induces endoplasmic reticulum-dependent apoptosis.",2012,10.1089/dna.2012.1682,https://pubmed.ncbi.nlm.nih.gov/22731819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDC1,ENSG00000135314,Unsafe,19129511,"Gene birth, death, and divergence: the different scenarios of reproduction-related gene evolution.",2009,10.1095/biolreprod.108.073684,https://pubmed.ncbi.nlm.nih.gov/19129511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDC1L,ENSG00000256980,Unsafe,41510809,"Identification of KHDC1L, a DUX4-regulated protein, as a novel plasma biomarker in facioscapulohumeral muscular dystrophy.",2026,10.1093/hmg/ddaf183,https://pubmed.ncbi.nlm.nih.gov/41510809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDC1L,ENSG00000256980,Unsafe,42630082,Biomarkers in facioscapulohumeral muscular dystrophy.,2026,10.1097/wco.0000000000001513,https://pubmed.ncbi.nlm.nih.gov/42630082/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDC1L,ENSG00000256980,Unsafe,36734243,Upregulation of KHDC1L promotes the proliferation and inhibits apoptosis in head and neck squamous cell carcinoma.,2023,10.1080/15592294.2023.2175168,https://pubmed.ncbi.nlm.nih.gov/36734243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,42253124,Endothelin-1 overexpression in mice increases vascular Vegfa164 and Vegfa188 alternative splice isoforms via enhanced Khdrbs3 expression.,2026,10.1097/hjh.0000000000004363,https://pubmed.ncbi.nlm.nih.gov/42253124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,41931390,Host microRNA-31-5p regulates KHDRBS3 expression and modulates viral gene expression during KSHV lytic reactivation.,2026,10.1016/j.celrep.2026.117160,https://pubmed.ncbi.nlm.nih.gov/41931390/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,41530494,Sarcomeric remodelling in human heart failure unraveled by single molecule long read sequencing.,2026,10.1038/s44321-025-00370-9,https://pubmed.ncbi.nlm.nih.gov/41530494/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,41417173,Roles of KHDRBS2 and KHDRBS3 in prostate cancer progression and AR-V7 regulation.,2025,10.1007/s12672-025-04294-1,https://pubmed.ncbi.nlm.nih.gov/41417173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,41477642,A transcriptomic atlas at bulk and single-cell levels identifies novel transcriptional and splicing regulators of ECM homeostasis in osteoarthritis.,2025,10.3389/fgene.2025.1690319,https://pubmed.ncbi.nlm.nih.gov/41477642/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,41023014,An efficient deep learning network for brain stroke detection using salp shuffled shepherded optimization.,2025,10.1038/s41598-025-17725-4,https://pubmed.ncbi.nlm.nih.gov/41023014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,42653832,Protective Effects of the Ethanolic Leaf Extract of &lt;i&gt;Ocimum sanctum&lt;/i&gt; L. on Collagen-Induced Human Platelet Aggregation and CCl&lt;sub&gt;4&lt;/sub&gt;-Induced Hepatotoxicity in Rats: Molecular Docking Analysis of Platelet Activation Signaling Targets.,2026,10.3390/molecules31162749,https://pubmed.ncbi.nlm.nih.gov/42653832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,40643493,Modulation of Neurexins Alternative Splicing by Cannabinoid Receptors 1 (CB1) Signaling.,2025,10.3390/cells14130972,https://pubmed.ncbi.nlm.nih.gov/40643493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,41843499,Comparative embryogenesis of two salp species reveals rogue development and evolutionary divergence from sessile tunicates.,2026,10.1371/journal.pbio.3003636,https://pubmed.ncbi.nlm.nih.gov/41843499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,41708805,Alternative splicing and differential gene expression during changes in endometrial receptivity in patients with recurrent implantation failure.,2026,10.1038/s41598-026-40386-w,https://pubmed.ncbi.nlm.nih.gov/41708805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,42905012,Both Membrane-Bound and Soluble Alkaline Phosphatases Bind Cry1Ca to Potentiate Its Toxicity in Spodoptera litura.,2026,10.1021/acs.jafc.6c06572,https://pubmed.ncbi.nlm.nih.gov/42905012/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,38324473,Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development.,2024,10.1093/nar/gkae071,https://pubmed.ncbi.nlm.nih.gov/38324473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,40760232,KHDRBS3-mediated upregulation of circ_0024107 in gastric cancer cells and GC-MSCs synergistically drives gastric cancer cell migration and invasion.,2025,10.1007/s11626-025-01104-4,https://pubmed.ncbi.nlm.nih.gov/40760232/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,40292405,Exosome-Delivered circFOXP1 Upregulates Autophagy and Promotes Hepatocellular Carcinoma Progression Through Its Encoded p196 Protein Targeting the KHDRBS3/ULK1 Axis.,2025,10.2147/ijn.s505157,https://pubmed.ncbi.nlm.nih.gov/40292405/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,41701411,Therapeutic effects of Gardenia jasminoides Ellis on salpingitis in laying hens: mechanisms of inflammatory regulation and egg quality improvement.,2026,10.1007/s11259-026-11118-2,https://pubmed.ncbi.nlm.nih.gov/41701411/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,40651363,Integrated transcriptome analysis and in silico investigations identify KHDRBS3 to target with steroidal lactone in paclitaxel resistance breast cancer.,2025,10.1016/j.bbrc.2025.152332,https://pubmed.ncbi.nlm.nih.gov/40651363/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,42024922,Optimized Gene Selection Using Nomadic People and Salp Swarm Algorithms for Cancer Detection.,2026,10.1109/tcbbio.2026.3687099,https://pubmed.ncbi.nlm.nih.gov/42024922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,39413902,KHDRBS3 facilitates self-renewal and temozolomide resistance of glioblastoma cell lines.,2024,10.1016/j.lfs.2024.123132,https://pubmed.ncbi.nlm.nih.gov/39413902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,42031862,WS-SSA: workflow scheduling in cloud computing using salp swarm algorithm.,2026,10.1038/s41598-026-48037-w,https://pubmed.ncbi.nlm.nih.gov/42031862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,41002872,An Enhanced Knowledge Salp Swarm Algorithm for Solving the Numerical Optimization and Seed Classification Tasks.,2025,10.3390/biomimetics10090638,https://pubmed.ncbi.nlm.nih.gov/41002872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,41286029,Identification of a Treg-related gene signature for predicting prognosis and immunosuppression in skin cutaneous melanoma.,2025,10.1007/s10238-025-01941-3,https://pubmed.ncbi.nlm.nih.gov/41286029/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,42345679,Reverse Mutation for Optimization Learning Artificial Lemming Algorithm and Its Application in Engineering.,2026,10.3390/biomimetics11060389,https://pubmed.ncbi.nlm.nih.gov/42345679/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,40055377,Development of a MVI associated HCC prognostic model through single cell transcriptomic analysis and 101 machine learning algorithms.,2025,10.1038/s41598-025-91475-1,https://pubmed.ncbi.nlm.nih.gov/40055377/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,39571198,Distinct phenotypes of salivaricin-producing Ligilactobacillus salivarius isolated from the gastrointestinal tract of broiler chickens and laying hens.,2025,10.1016/j.psj.2024.104537,https://pubmed.ncbi.nlm.nih.gov/39571198/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,41974868,Arithmetic optimization algorithm based PID control for reduced order motorized wheelchairs with real time MIL SIL PIL validation.,2026,10.1038/s41598-026-47689-y,https://pubmed.ncbi.nlm.nih.gov/41974868/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,40681526,Multi robot exploration using an advanced multi-objective salp swarm algorithm for efficient coverage and performance.,2025,10.1038/s41598-025-08194-w,https://pubmed.ncbi.nlm.nih.gov/40681526/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,39828713,Driver identification in advanced transportation systems using osprey and salp swarm optimized random forest model.,2025,10.1038/s41598-024-84710-8,https://pubmed.ncbi.nlm.nih.gov/39828713/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,40796932,"Design of a liquid cooled battery thermal management system using neural networks, cheetah optimizer and salp swarm algorithm.",2025,10.1038/s41598-025-15359-0,https://pubmed.ncbi.nlm.nih.gov/40796932/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,40258903,Salp Navigation and Competitive based Parrot Optimizer (SNCPO) for efficient extreme learning machine training and global numerical optimization.,2025,10.1038/s41598-025-97661-5,https://pubmed.ncbi.nlm.nih.gov/40258903/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,40634405,Improved salp swarm algorithm-driven deep CNN for brain tumor analysis.,2025,10.1038/s41598-025-09326-y,https://pubmed.ncbi.nlm.nih.gov/40634405/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,40567648,Improved salp swarm algorithm based optimization of mobile task offloading.,2025,10.7717/peerj-cs.2818,https://pubmed.ncbi.nlm.nih.gov/40567648/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,42645258,Hyperspectral Image Classification Based on an Improved Octopus Optimization Algorithm.,2026,10.3390/biomimetics11080542,https://pubmed.ncbi.nlm.nih.gov/42645258/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,39521883,Self-learning salp swarm algorithm for global optimization and its application in multi-layer perceptron model training.,2024,10.1038/s41598-024-77440-4,https://pubmed.ncbi.nlm.nih.gov/39521883/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,38658444,Comparative analysis of ultrasound-guided percutaneous biopsy of native kidneys in children and adults using the free-flank supine antero-lateral decubitus positioning.,2024,10.1007/s00261-024-04316-6,https://pubmed.ncbi.nlm.nih.gov/38658444/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,41807609,Machine learning-assisted evolutionary optimization of hole quality and surface integrity in abrasive waterjet drilling of polycarbonate.,2026,10.1038/s41598-026-42482-3,https://pubmed.ncbi.nlm.nih.gov/41807609/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,39290070,Data-driven drug treatment: enhancing clinical decision-making with SalpPSO-optimized GraphSAGE.,2026,10.1080/10255842.2024.2399012,https://pubmed.ncbi.nlm.nih.gov/39290070/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,10564820,"Salpalpha and Salpbeta, growth-arresting homologs of Sam68.",1999,10.1016/s0378-1119(99)00421-7,https://pubmed.ncbi.nlm.nih.gov/10564820/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,10332027,T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis.,1999,10.1093/hmg/8.6.959,https://pubmed.ncbi.nlm.nih.gov/10332027/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KHDRBS3,ENSG00000131773,Unsafe,10077576,Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis.,1999,10.1073/pnas.96.6.2710,https://pubmed.ncbi.nlm.nih.gov/10077576/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA0825,ENSG00000185261,Unsafe,41010063,Novel &lt;i&gt;KIAA0825&lt;/i&gt; Variants Underlie Nonsyndromic Postaxial Polydactyly.,2025,10.3390/genes16091118,https://pubmed.ncbi.nlm.nih.gov/41010063/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA0825,ENSG00000185261,Unsafe,39908274,Epigenetic insights into fertility: involvement of immune cell methylation in dairy cows reproduction†.,2026,10.1093/biolre/ioaf020,https://pubmed.ncbi.nlm.nih.gov/39908274/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA0825,ENSG00000185261,Unsafe,41618404,Epigenome-wide association study of leukocyte telomere length and their effects on smoking-induced lung tumorigenesis: insights from the Dongfeng-Tongji cohort study.,2026,10.1186/s13148-026-02053-9,https://pubmed.ncbi.nlm.nih.gov/41618404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA0825,ENSG00000185261,Unsafe,42390887,Genomic Landscape and Perinatal Outcomes of Fetal Polydactyly: A Retrospective Cohort Study Integrating CNV-seq and Trio-ES.,2026,10.1002/pd.70216,https://pubmed.ncbi.nlm.nih.gov/42390887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA0825,ENSG00000185261,Unsafe,40676597,"Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease.",2025,10.1186/s13059-025-03564-z,https://pubmed.ncbi.nlm.nih.gov/40676597/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA0825,ENSG00000185261,Unsafe,39819503,Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis.,2025,10.1186/s13148-024-01803-x,https://pubmed.ncbi.nlm.nih.gov/39819503/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA0825,ENSG00000185261,Unsafe,37107627,Identification of GLI1 and KIAA0825 Variants in Two Families with Postaxial Polydactyly.,2023,10.3390/genes14040869,https://pubmed.ncbi.nlm.nih.gov/37107627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA0825,ENSG00000185261,Unsafe,35886013,Prenatal Detection of Novel Compound Heterozygous Splice Site Variants of the &lt;i&gt;KIAA0825&lt;/i&gt; Gene in a Fetus with Postaxial Polydactyly Type A.,2022,10.3390/genes13071230,https://pubmed.ncbi.nlm.nih.gov/35886013/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA0825,ENSG00000185261,Unsafe,30982135,Variants in KIAA0825 underlie autosomal recessive postaxial polydactyly.,2019,10.1007/s00439-019-02000-0,https://pubmed.ncbi.nlm.nih.gov/30982135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA0825,ENSG00000185261,Unsafe,40924252,Landscape genomics analysis reveals the genetic basis underlying cashmere goats and dairy goats adaptation to frigid environments.,2025,10.1007/s44154-025-00254-5,https://pubmed.ncbi.nlm.nih.gov/40924252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA0825,ENSG00000185261,Unsafe,38214344,Regulator of G protein signalling 18 promotes osteocyte proliferation by activating the extracellular signal‑regulated kinase signalling pathway.,2024,10.3892/ijmm.2024.5346,https://pubmed.ncbi.nlm.nih.gov/38214344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA0825,ENSG00000185261,Unsafe,37212316,Integration and viral oncogene expression of human papillomavirus type 16 in oropharyngeal squamous cell carcinoma and gastric cancer.,2023,10.1002/jmv.28761,https://pubmed.ncbi.nlm.nih.gov/37212316/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA0825,ENSG00000185261,Unsafe,39926593,Genome-wide association studies with prolapsed gland of the third eyelid in dogs.,2024,10.3389/fvets.2024.1520155,https://pubmed.ncbi.nlm.nih.gov/39926593/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA0825,ENSG00000185261,Unsafe,33776623,A Frameshift Variant in KIAA0825 Causes Postaxial Polydactyly.,2021,10.1159/000512062,https://pubmed.ncbi.nlm.nih.gov/33776623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA0825,ENSG00000185261,Unsafe,36067927,A novel homozygous variant in the GLI1 underlies postaxial polydactyly in a large consanguineous family with intra familial variable phenotypes.,2022,10.1016/j.ejmg.2022.104599,https://pubmed.ncbi.nlm.nih.gov/36067927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA0825,ENSG00000185261,Unsafe,34721536,A Novel Homozygous Missense Mutation in the Zinc Finger DNA Binding Domain of GLI1 Causes Recessive Post-Axial Polydactyly.,2021,10.3389/fgene.2021.746949,https://pubmed.ncbi.nlm.nih.gov/34721536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA0825,ENSG00000185261,Unsafe,27381092,Estrogen-related receptor gamma implicated in a phenotype including hearing loss and mild developmental delay.,2016,10.1038/ejhg.2016.64,https://pubmed.ncbi.nlm.nih.gov/27381092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1328,ENSG00000150477,Unsafe,28596423,"Integration of over 9,000 mass spectrometry experiments builds a global map of human protein complexes.",2017,10.15252/msb.20167490,https://pubmed.ncbi.nlm.nih.gov/28596423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1328,ENSG00000150477,Unsafe,28407444,Familial 18q12.2 deletion supports the role of RNA-binding protein CELF4 in autism spectrum disorders.,2017,10.1002/ajmg.a.38205,https://pubmed.ncbi.nlm.nih.gov/28407444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1328,ENSG00000150477,Unsafe,15656913,"Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3.",2005,10.1186/1471-2121-6-3,https://pubmed.ncbi.nlm.nih.gov/15656913/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,42567511,O-mannosylation and furin processing are critical maturation events for the KIAA1549 protein implicated in pediatric pilocytic astrocytomas.,2026,10.1016/j.jbc.2026.113403,https://pubmed.ncbi.nlm.nih.gov/42567511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,42714308,O-mannosylation and protein maturation checkpoints represent therapeutic opportunities in BRAF fusion protein oncogenesis.,2026,10.1158/2159-8290.cd-25-1114,https://pubmed.ncbi.nlm.nih.gov/42714308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,42894377,Distinct Clinicogenomic Contexts of BRAF-Altered Gliomas and Glioneuronal Tumors: A Nationwide Real-World Study.,2026,10.1111/cas.70568,https://pubmed.ncbi.nlm.nih.gov/42894377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,42599848,H3K27M-Mutant Diffuse Leptomeningeal Glioneuronal Tumor Presenting as Communicating Hydrocephalus: Case Report and Literature Review.,2026,10.1159/pne/aeiag003,https://pubmed.ncbi.nlm.nih.gov/42599848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,41785221,An ex vivo functional biomarker of treatment response in pediatric low-grade glioma.,2026,10.1371/journal.pone.0331423,https://pubmed.ncbi.nlm.nih.gov/41785221/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,40968574,"Coexistence of IDH1 Mutation and KIAA1549::BRAF Fusion in a Diffuse Glioma: A Case Report With Clinical, Radiological, and Pathological Correlation.",2025,10.1111/neup.70027,https://pubmed.ncbi.nlm.nih.gov/40968574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,42120807,Tectal glioma with pilocytic astrocytoma morphology carrying a histone H3 K27M mutation and malignant transformation: a literature review.,2026,10.1007/s10014-026-00539-1,https://pubmed.ncbi.nlm.nih.gov/42120807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,42414678,Incidence and predictors of hemorrhage in pediatric low-grade glioma.,2026,10.1007/s11060-026-05699-w,https://pubmed.ncbi.nlm.nih.gov/42414678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,40550805,Multi-omics dissection of MAPK-driven senescence unveils therapeutic vulnerabilities in KIAA1549::BRAF-fusion pediatric low-grade glioma models.,2025,10.1038/s41392-025-02279-8,https://pubmed.ncbi.nlm.nih.gov/40550805/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,40240141,IRX2 and NPTX1 differential regulation of β-catenin underlies MEK-mediated proliferation in human neuroglial cells.,2025,10.1101/gad.352508.124,https://pubmed.ncbi.nlm.nih.gov/40240141/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,41659712,Case Report: Novel ASAP1::BRAF fusion in a young adult with low-grade temporal lobe glioma.,2026,10.3389/fonc.2026.1763047,https://pubmed.ncbi.nlm.nih.gov/41659712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,40403356,Comprehensive transcriptomic profiling of fusions and abnormal variant transcripts in pilocytic astrocytoma using NanoString nCounter technology.,2025,10.1016/j.prp.2025.156024,https://pubmed.ncbi.nlm.nih.gov/40403356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,41514664,Targeting the MAPK Pathway in Brain Tumors: Mechanisms and Therapeutic Opportunities.,2026,10.3390/cancers18010156,https://pubmed.ncbi.nlm.nih.gov/41514664/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,41363945,Unexpected [ 18 F] Fluciclovine Uptake in Pilocytic Astrocytoma: A Pediatric Case Report.,2026,10.1097/rlu.0000000000006233,https://pubmed.ncbi.nlm.nih.gov/41363945/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,42720781,Efficacy and safety of trametinib use in pediatric brain tumors in a low- to middle-income country.,2026,10.1007/s00381-026-07464-w,https://pubmed.ncbi.nlm.nih.gov/42720781/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,42088911,Spinal high-grade astrocytoma with piloid features arising in a patient with molecularly confirmed cerebellar pilocytic astrocytoma.,2026,10.1093/noajnl/vdag104,https://pubmed.ncbi.nlm.nih.gov/42088911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,41819797,Multiclass Radiomics-Based Prediction of &lt;i&gt;BRAF&lt;/i&gt; Mutation Status in Pediatric Low-grade Gliomas Using Multisequence MRI.,2026,10.3174/ajnr.a9296,https://pubmed.ncbi.nlm.nih.gov/41819797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,41858343,Case Report: Molecular diagnostics and clinical courses of two adult spinal pilocytic astrocytoma long-term survivors with GTF2I::BRAF fusion.,2026,10.3389/fonc.2026.1670639,https://pubmed.ncbi.nlm.nih.gov/41858343/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,42089945,Nationwide genomic data analysis of central nervous system tumors in Japan based on C-CAT database.,2026,10.1007/s10147-026-03031-0,https://pubmed.ncbi.nlm.nih.gov/42089945/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,42348488,Recurrent Pediatric Pilocytic Astrocytoma with BRAFV600E and TP53 Mutations: Case Report and Literature Review.,2026,10.1159/000553295,https://pubmed.ncbi.nlm.nih.gov/42348488/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,41596345,From Molecular Alterations to the Targeted Therapy: Treatment of Thalamic Glioma in Pediatric Patients.,2026,10.3390/ijms27020695,https://pubmed.ncbi.nlm.nih.gov/41596345/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,41661389,Molecular convergence enables precision medicine for pediatric low grade gliomas.,2026,10.1007/s12672-026-04639-4,https://pubmed.ncbi.nlm.nih.gov/41661389/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,41749803,From Diagnosis Delay to Targeted Therapy: A Retrospective Study of Pediatric DLGNT with a Comprehensive Literature Review.,2026,10.3390/cancers18040549,https://pubmed.ncbi.nlm.nih.gov/41749803/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,40588233,Multi-pronged analysis of pediatric low-grade glioma and ganglioglioma reveals a unique tumor microenvironment associated with BRAF alterations.,2025,10.1111/bpa.70023,https://pubmed.ncbi.nlm.nih.gov/40588233/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,40241281,"A phase 2 PBTC study of selumetinib for recurrent/progressive pediatric low-grade glioma: Strata 2, 5, and 6 with long-term outcomes on strata 1, 3, and 4.",2025,10.1093/neuonc/noaf065,https://pubmed.ncbi.nlm.nih.gov/40241281/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,40737104,Evaluating Gene Fusions as Prognostic Biomarkers and Therapeutic Targets in Immune Checkpoint Blockade-Treated Advanced Melanoma: A Retrospective Analysis.,2025,10.1158/2767-9764.crc-25-0204,https://pubmed.ncbi.nlm.nih.gov/40737104/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,39533816,Unconventional Histopathological Features With &lt;i&gt;KIAA1549::BRAF&lt;/i&gt; Fusion in Advanced Prostatic Adenocarcinoma.,2025,10.1177/10668969241295687,https://pubmed.ncbi.nlm.nih.gov/39533816/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,38723228,State of the Art in Low-Grade Glioma Management: Insights From Isocitrate Dehydrogenase and Beyond.,2024,10.1200/edbk_431450,https://pubmed.ncbi.nlm.nih.gov/38723228/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,38846974,Continuous response despite reduced dose of trametinib as single agent in an adolescent with a relapsed disseminated pediatric low-grade glioma KIAA1549-BRAF fusion positive: a case report and review of the literature.,2024,10.3389/fonc.2024.1381354,https://pubmed.ncbi.nlm.nih.gov/38846974/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,39324010,Heterogeneous SSTR2 target expression and a novel KIAA1549::BRAF fusion clone in a progressive metastatic lesion following 177Lutetium-DOTATATE molecular radiotherapy in neuroblastoma: a case report.,2024,10.3389/fonc.2024.1408729,https://pubmed.ncbi.nlm.nih.gov/39324010/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,41695364,Hepatic carcinosarcoma: a rare and aggressive case with unusual molecular signature!,2026,10.3389/fonc.2026.1759219,https://pubmed.ncbi.nlm.nih.gov/41695364/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,37978951,Everolimus for Children With Recurrent or Progressive Low-Grade Glioma: Results From the Phase II PNOC001 Trial.,2024,10.1200/jco.23.01838,https://pubmed.ncbi.nlm.nih.gov/37978951/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,38291372,"LOGGIC/FIREFLY-2: a phase 3, randomized trial of tovorafenib vs. chemotherapy in pediatric and young adult patients with newly diagnosed low-grade glioma harboring an activating RAF alteration.",2024,10.1186/s12885-024-11820-x,https://pubmed.ncbi.nlm.nih.gov/38291372/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,39847453,Genetic ancestry superpopulations show distinct prevalence and outcomes across pediatric central nervous system tumors from the Pediatric Brain Tumor Atlas and Pediatric Neuro-Oncology Consortium.,2025,10.1093/neuonc/noaf017,https://pubmed.ncbi.nlm.nih.gov/39847453/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1549,ENSG00000122778,Unsafe,30120214,"Homozygous variants in KIAA1549, encoding a ciliary protein, are associated with autosomal recessive retinitis pigmentosa.",2018,10.1136/jmedgenet-2018-105364,https://pubmed.ncbi.nlm.nih.gov/30120214/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1586,ENSG00000168116,Unsafe,41865909,Small Genome-wide association study of insect bite hypersensitivity in Hucul horses.,2026,10.1016/j.jevs.2026.105857,https://pubmed.ncbi.nlm.nih.gov/41865909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1586,ENSG00000168116,Unsafe,31572720,Systematic Characterization of Circular RNA-Associated CeRNA Network Identified Novel circRNA Biomarkers in Alzheimer's Disease.,2019,10.3389/fbioe.2019.00222,https://pubmed.ncbi.nlm.nih.gov/31572720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIAA1586,ENSG00000168116,Unsafe,21540310,A genome-wide association study reveals evidence of association with sarcoidosis at 6p12.1.,2011,10.1183/09031936.00001711,https://pubmed.ncbi.nlm.nih.gov/21540310/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KICS2,ENSG00000174206,Unsafe,39824192,"Bi-allelic KICS2 mutations impair KICSTOR complex-mediated mTORC1 regulation, causing intellectual disability and epilepsy.",2025,10.1016/j.ajhg.2024.12.019,https://pubmed.ncbi.nlm.nih.gov/39824192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KICS2,ENSG00000174206,Unsafe,41401028,FBXO2-mediated KPTN ubiquitination promotes amino acid-dependent mTORC1 signaling and tumor growth.,2026,10.1172/jci195031,https://pubmed.ncbi.nlm.nih.gov/41401028/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KICS2,ENSG00000174206,Unsafe,35776786,Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling.,2022,10.1126/sciadv.abn3868,https://pubmed.ncbi.nlm.nih.gov/35776786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KICS2,ENSG00000174206,Unsafe,33685991,Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors.,2021,10.1158/0008-5472.can-20-3232,https://pubmed.ncbi.nlm.nih.gov/33685991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KICS2,ENSG00000174206,Unsafe,28199306,KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.,2017,10.1038/nature21423,https://pubmed.ncbi.nlm.nih.gov/28199306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KICS2,ENSG00000174206,Unsafe,27609023,A 19-Gene expression signature as a predictor of survival in colorectal cancer.,2016,10.1186/s12920-016-0218-1,https://pubmed.ncbi.nlm.nih.gov/27609023/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,42449106,KIF14 silencing suppresses cell proliferation and enhances chemosensitivity by modulating 53BP1 nucleocytoplasmic shuttling in non-WNT/non-SHH medulloblastoma.,2026,10.1038/s41420-026-03252-2,https://pubmed.ncbi.nlm.nih.gov/42449106/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,40931756,The E2F1-KIF14 axis drives focal adhesion formation and promotes colorectal cancer metastasis.,2026,10.3724/abbs.2025158,https://pubmed.ncbi.nlm.nih.gov/40931756/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,42036047,Ubiquitin E3 ligase MYCBP2 targets KIF14 and contributes to acute myeloid leukemia progression.,2026,10.1016/j.jbc.2026.112204,https://pubmed.ncbi.nlm.nih.gov/42036047/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,41410179,Validation of the important role and prognostic value of KIF14 in triple-negative breast cancer.,2025,10.1080/15384047.2025.2600705,https://pubmed.ncbi.nlm.nih.gov/41410179/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,42083583,KIF14-AKT axis regulates ferroptosis sensitivity in triple-negative breast cancer.,2026,10.1515/biol-2025-1324,https://pubmed.ncbi.nlm.nih.gov/42083583/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,40374610,Identification of tRF-29-79MP9P9NH525 as a biomarker and tumor suppressor of gastric cancer via regulating KIF14/AKT pathway.,2025,10.1038/s41420-025-02514-9,https://pubmed.ncbi.nlm.nih.gov/40374610/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,42843039,Deciphering the role of microplastics-related molecular signatures in cervical cancer progression: Transcriptomic analysis and diagnostic model development.,2026,10.1016/j.bbrc.2026.154678,https://pubmed.ncbi.nlm.nih.gov/42843039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,40186141,KIF14 plays a role in the regulation of the cell cycle and has implications for prognosis in clear cell renal cell carcinoma.,2025,10.1186/s12894-025-01732-8,https://pubmed.ncbi.nlm.nih.gov/40186141/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,41511650,KIF14 in cancer biology: implications for diagnosis and therapy.,2026,10.1007/s10585-025-10389-4,https://pubmed.ncbi.nlm.nih.gov/41511650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,40075652,KIF11 and KIF14 Are a Novel Potential Prognostic Biomarker in Patients with Endometrioid Carcinoma.,2025,10.3390/cancers17050804,https://pubmed.ncbi.nlm.nih.gov/40075652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,40092935,Kinesin family member 14 expression and its clinical implications in colorectal cancer.,2025,10.4251/wjgo.v17.i3.102696,https://pubmed.ncbi.nlm.nih.gov/40092935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,42415117,Targeting HASPIN-mediated H3T3 phosphorylation disrupts an epigenetic-kinesin axis to suppress colorectal cancer mitotic progression.,2026,10.1186/s12943-026-02723-5,https://pubmed.ncbi.nlm.nih.gov/42415117/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,40927771,RCN1 Binds KIF14 and Promotes the Malignant Growth of Cervical Cancer Through the PI3K-AKT Pathway.,2025,10.2147/ijgm.s531003,https://pubmed.ncbi.nlm.nih.gov/40927771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,42651835,Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders.,2026,10.3390/cimb48080837,https://pubmed.ncbi.nlm.nih.gov/42651835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,41026307,Identification of KIF14 as a ferroptosis biomarker for predicting the prognosis and immunotherapy efficacy of bladder cancer.,2025,10.1007/s12672-025-03492-1,https://pubmed.ncbi.nlm.nih.gov/41026307/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,41864930,A 13-gene prognostic model developed using machine learning to predict the response to neoadjuvant chemoradiotherapy in rectal carcinoma.,2026,10.1186/s12935-026-04256-9,https://pubmed.ncbi.nlm.nih.gov/41864930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,42529891,Kinesins in Bladder Cancer: Integrating Molecular Mechanisms and Treatment Approaches.,2026,10.1002/cbin.70191,https://pubmed.ncbi.nlm.nih.gov/42529891/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,41766902,Construction and validation of a novel diagnostic model for esophageal squamous cell carcinoma: an integrated analysis of multi-omics data.,2026,10.3389/fimmu.2026.1685902,https://pubmed.ncbi.nlm.nih.gov/41766902/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,40840079,Disulfidptosis-associated gene signature predicts prognosis and radioresistance in NSCLC.,2025,10.1016/j.tranon.2025.102496,https://pubmed.ncbi.nlm.nih.gov/40840079/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,40951482,Cytoarchitectural changes in the developing cerebellar cortex of the &lt;i&gt;laggard&lt;/i&gt; mutant mouse.,2025,10.52225/narra.v5i2.2075,https://pubmed.ncbi.nlm.nih.gov/40951482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,40547137,"Kinesin family member 14 in digestive tract malignancies: Oncogenic mechanisms, clinical implications, and therapeutic prospects.",2025,10.4251/wjgo.v17.i6.105062,https://pubmed.ncbi.nlm.nih.gov/40547137/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,41016201,Kinesin superfamily proteins in cancer: unveiling their role in chemotherapy.,2025,10.1016/j.intimp.2025.115621,https://pubmed.ncbi.nlm.nih.gov/41016201/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,42180604,Multi-stage transcriptome analysis identifies hub genes and regulatory mechanisms driving cervical cancer progression.,2026,10.7717/peerj.21255,https://pubmed.ncbi.nlm.nih.gov/42180604/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,41751958,FOXM1 Signaling Network Transcriptionally Upregulates Expression of Proteins Involved in Mitotic Progression to Induce High Proliferation and Chromosomal Instability in Androgen Receptor-Low Triple-Negative Breast Cancer.,2026,10.3390/ijms27041823,https://pubmed.ncbi.nlm.nih.gov/41751958/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,36227151,Noncoding RNAs-mediated overexpression of KIF14 is associated with tumor immune infiltration and unfavorable prognosis in lung adenocarcinoma.,2022,10.18632/aging.204332,https://pubmed.ncbi.nlm.nih.gov/36227151/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,38498903,BUB1/KIF14 complex promotes anaplastic thyroid carcinoma progression by inducing chromosome instability.,2024,10.1111/jcmm.18182,https://pubmed.ncbi.nlm.nih.gov/38498903/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,38033864,Novel circular RNA circ-0002727 regulates miR-144-3p/KIF14 pathway to promote lung adenocarcinoma progression.,2023,10.3389/fcell.2023.1249174,https://pubmed.ncbi.nlm.nih.gov/38033864/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,38560563,Development of a cell adhesion-based prognostic model for multiple myeloma: Insights into chemotherapy response and potential reversal of adhesion effects.,2024,10.32604/or.2023.043647,https://pubmed.ncbi.nlm.nih.gov/38560563/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF14,ENSG00000118193,Unsafe,40828203,Integrated Analysis of Bulk and Single-Cell Transcriptomics Identifies Prognostic Biomarkers in Breast Cancer Metastasis.,2026,10.1007/s10528-025-11228-7,https://pubmed.ncbi.nlm.nih.gov/40828203/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,42055325,Kif15 orchestrates neuronal-microglial communication via CX3CL1 to impede nerve regeneration.,2026,10.1016/j.jbc.2026.113090,https://pubmed.ncbi.nlm.nih.gov/42055325/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,42107035,"KIF15 (Kinesin-12): molecular biology, physiological functions, and roles in disease.",2026,10.1007/s00432-026-06501-0,https://pubmed.ncbi.nlm.nih.gov/42107035/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,41935349,In Silico Multi-omics Analyses of Kinesin Family Member 15 in Pan-Cancer and Validation in Tissue Microarray.,2026,10.2174/0115680096420482251130063549,https://pubmed.ncbi.nlm.nih.gov/41935349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,41872824,Identification and validation of Kif15 as a potential diagnostic and prognostic biomarker in colon cancer.,2026,10.1186/s12876-026-04755-z,https://pubmed.ncbi.nlm.nih.gov/41872824/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,40892874,Deficiency of Kif15 impairing synaptic development leads to mood disorder in mice.,2025,10.1371/journal.pgen.1011839,https://pubmed.ncbi.nlm.nih.gov/40892874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,41912772,The YY1-KIF15-PRDX1 axis promotes gastric cancer progression by inducing mitochondrial ROS imbalance.,2026,10.1038/s41388-026-03722-y,https://pubmed.ncbi.nlm.nih.gov/41912772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,41584727,Tumor Microenvironment Characterization Identifies &lt;i&gt;KIF15&lt;/i&gt; as an Immunosuppressive Driver in Breast Cancer.,2026,10.1155/humu/8861116,https://pubmed.ncbi.nlm.nih.gov/41584727/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,39430242,KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300.,2024,10.7150/ijbs.98668,https://pubmed.ncbi.nlm.nih.gov/39430242/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,42651835,Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders.,2026,10.3390/cimb48080837,https://pubmed.ncbi.nlm.nih.gov/42651835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,41381790,Identification and validation of palmitoylation metabolism related biomarkers in osteoarthritis using transcriptomic and single cell RNA sequencing analyses.,2025,10.1038/s41598-025-31218-4,https://pubmed.ncbi.nlm.nih.gov/41381790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,42479720,CDCA8 regulates ATP5F1A protein stability and malignant phenotypes in wilms tumor cells: Prognostic implications and mechanistic insights.,2026,10.1371/journal.pone.0353696,https://pubmed.ncbi.nlm.nih.gov/42479720/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,40817978,The multifaceted role of KIF15 in cancer progression and therapy.,2025,10.1007/s10637-025-01572-1,https://pubmed.ncbi.nlm.nih.gov/40817978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,40087774,Atractylenolide I ameliorated the growth and enzalutamide resistance of castration-resistant prostate cancer by targeting KIF15.,2025,10.1186/s13020-025-01086-1,https://pubmed.ncbi.nlm.nih.gov/40087774/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,40476037,RETRACTION: KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma.,2025,10.1155/ancp/9807235,https://pubmed.ncbi.nlm.nih.gov/40476037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,39914618,Deficiency of KIF15 contributes to oxaliplatin-induced cold hypersensitivity by limiting annexin A2 and enhancing TRPA1 localization in DRG neuronal membrane.,2025,10.1016/j.neuropharm.2025.110343,https://pubmed.ncbi.nlm.nih.gov/39914618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,39752482,Klp2-mediated Rsp1-Mto1 colocalization inhibits microtubule-dependent microtubule assembly in fission yeast.,2025,10.1126/sciadv.adq0670,https://pubmed.ncbi.nlm.nih.gov/39752482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,39504712,METTL3 methylated KIF15 promotes nasopharyngeal carcinoma progression and radiation resistance by blocking ATG7-mediated autophagy through the activation of STAT3 pathway.,2025,10.1016/j.tranon.2024.102161,https://pubmed.ncbi.nlm.nih.gov/39504712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,42306525,Goatpox virus Hrf-063 interacts with host eIF4A1 and is associated with altered expression of antiviral signaling-related factors.,2026,10.3389/fcimb.2026.1840976,https://pubmed.ncbi.nlm.nih.gov/42306525/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,40405591,Identifying prognostic targets in metastatic prostate cancer beyond AR.,2025,10.1002/2211-5463.70059,https://pubmed.ncbi.nlm.nih.gov/40405591/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,40460471,Nitric oxide regulates spindle dynamics to modulate the maturation of goat oocytes.,2025,10.1016/j.theriogenology.2025.117517,https://pubmed.ncbi.nlm.nih.gov/40460471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,39232293,Polystyrene nanoplastics accelerate atherosclerosis: Unraveling the impact on smooth muscle cells through KIF15-mediated migration.,2024,10.1016/j.ecoenv.2024.116983,https://pubmed.ncbi.nlm.nih.gov/39232293/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,41285333,"TOP2A, BUB1B, CENPF, KIF15 and MELK: Key senescence-related genes linked to prognosis and immune infiltration in lung adenocarcinoma.",2026,10.1016/j.ijbiomac.2025.149215,https://pubmed.ncbi.nlm.nih.gov/41285333/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,37266661,The mitotic spindle-related seven-gene predicts the prognosis and immune microenvironment of lung adenocarcinoma.,2023,10.1007/s00432-023-04906-9,https://pubmed.ncbi.nlm.nih.gov/37266661/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,39271768,Integrated machine learning algorithms identify KIF15 as a potential prognostic biomarker and correlated with stemness in triple-negative breast cancer.,2024,10.1038/s41598-024-72406-y,https://pubmed.ncbi.nlm.nih.gov/39271768/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,37894278,Inducing Mitotic Catastrophe as a Therapeutic Approach to Improve Outcomes in Ewing Sarcoma.,2023,10.3390/cancers15204911,https://pubmed.ncbi.nlm.nih.gov/37894278/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,37970344,KIF15 knockdown inhibits colorectal cancer proliferation and migration through affecting the ubiquitination modification of NRAS.,2023,,https://pubmed.ncbi.nlm.nih.gov/37970344/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,37641808,"Kinesin superfamily member 15 knockdown inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma.",2023,10.4196/kjpp.2023.27.5.457,https://pubmed.ncbi.nlm.nih.gov/37641808/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,40367801,Integrative network and computational toxicology reveal the molecular mechanisms in PFOA-induced spermatogenic disorder.,2025,10.1016/j.jenvman.2025.125754,https://pubmed.ncbi.nlm.nih.gov/40367801/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,38500277,Identification and Verification of Metabolism-related Immunotherapy Features and Prognosis in Lung Adenocarcinoma.,2025,10.2174/0109298673293414240314043529,https://pubmed.ncbi.nlm.nih.gov/38500277/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,38312843,Development and verification of a combined immune- and cancer-associated fibroblast related prognostic signature for colon adenocarcinoma.,2024,10.3389/fimmu.2024.1291938,https://pubmed.ncbi.nlm.nih.gov/38312843/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,35359374,Integrative Pan-Cancer Analysis of KIF15 Reveals Its Diagnosis and Prognosis Value in Nasopharyngeal Carcinoma.,2022,10.3389/fonc.2022.772816,https://pubmed.ncbi.nlm.nih.gov/35359374/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,37752167,Identification and verification of microtubule associated genes in lung adenocarcinoma.,2023,10.1038/s41598-023-42985-3,https://pubmed.ncbi.nlm.nih.gov/37752167/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF15,ENSG00000163808,Unsafe,12747765,Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.,2001,,https://pubmed.ncbi.nlm.nih.gov/12747765/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,41925903,"Investigation of ELF5, KIF18A, NPTX1 and COL23A1 genes in the pathophysiology of indirect inguinal hernia in children.",2026,10.1007/s00383-026-06400-y,https://pubmed.ncbi.nlm.nih.gov/41925903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,42647139,Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small Cell Lung Cancer.,2026,10.1158/2767-9764.crc-26-0560,https://pubmed.ncbi.nlm.nih.gov/42647139/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,42328720,KIF18A inhibitor prevents chromosomally unstable osteosarcoma growth by activating spindle assembly checkpoint.,2026,10.1080/15384047.2026.2689181,https://pubmed.ncbi.nlm.nih.gov/42328720/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,42804149,"KIF18A knockdown enhances oxidative phosphorylation, suggesting a metabolic basis for antiviral activity against influenza A virus.",2026,10.1007/s13258-026-01810-7,https://pubmed.ncbi.nlm.nih.gov/42804149/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,42260994,Multi-Omics Integration Reveals Incomplete Reactivation of Developmental Cell-Cycle Programs in Adult Human Infarcted Hearts.,2026,10.1111/cbdd.70337,https://pubmed.ncbi.nlm.nih.gov/42260994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,41091720,Suppression of kinesin family member-18A diminishes progression and induces apoptotic cell death of gemcitabine-resistant cholangiocarcinoma cells by modulating PI3K/Akt/mTOR and NF-κB pathways.,2025,10.1371/journal.pone.0334147,https://pubmed.ncbi.nlm.nih.gov/41091720/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,40596695,Anapc5 and Anapc7 as genetic modifiers of KIF18A function in fertility and mitotic progression.,2025,10.1038/s41598-025-08766-w,https://pubmed.ncbi.nlm.nih.gov/40596695/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,41082523,KIF18A induces the EMT process of hepatoma cells through the 5-LOX-dependent arachidonic acid pathway.,2025,10.1371/journal.pone.0333385,https://pubmed.ncbi.nlm.nih.gov/41082523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,41198558,Deciphering the Role of KIF18A in Osteosarcoma Progression: An Integrative Analysis and Experimental Validation.,2025,10.31083/fbl44663,https://pubmed.ncbi.nlm.nih.gov/41198558/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,40040635,Integrated Profiling Delineated KIF18A as a Significant Biomarker Associated with Both Prognostic Outcomes and Immune Response in Pancreatic Cancer.,2025,10.2147/itt.s497284,https://pubmed.ncbi.nlm.nih.gov/40040635/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,41591363,Loss of JAK1 Function Causes G2-M Cell-Cycle Defects Vulnerable to KIF18A Inhibition.,2026,10.1158/0008-5472.can-25-1423,https://pubmed.ncbi.nlm.nih.gov/41591363/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,41369352,The KIF18A Inhibitor ATX020 Induces Mitotic Arrest and DNA Damage in Chromosomally Instable High-Grade Serous Ovarian Cancer Cells.,2025,10.3390/cells14231863,https://pubmed.ncbi.nlm.nih.gov/41369352/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,39816554,KIF18A and CDK1 as combined therapeutic targets in cervical and endometrial carcinomas: based on bioinformatics analysis and in vitro experiments.,2024,10.21037/tcr-24-1831,https://pubmed.ncbi.nlm.nih.gov/39816554/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,41986639,Early detection of oral squamous cell carcinoma using five tumor-associated autoantibodies and a Naive Bayes-based machine learning model.,2026,10.1038/s41598-026-48821-8,https://pubmed.ncbi.nlm.nih.gov/41986639/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,41569184,Identification and Validation of Prognostic Biomarker Signatures Associated with Overall Survival in Colorectal Cancer: Evidence from Bioinformatics Analysis and an in vivo Study.,2026,10.31557/apjcp.2026.27.1.163,https://pubmed.ncbi.nlm.nih.gov/41569184/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,39747049,Targeting chromosomally unstable tumors with a selective KIF18A inhibitor.,2025,10.1038/s41467-024-55300-z,https://pubmed.ncbi.nlm.nih.gov/39747049/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,40175357,Targeting KIF18A triggers antitumor immunity and enhances efficiency of PD-1 blockade in colorectal cancer with chromosomal instability phenotype.,2025,10.1038/s41420-025-02437-5,https://pubmed.ncbi.nlm.nih.gov/40175357/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,39749722,KIF18A Is a Novel Target of JNK1/c-Jun Signaling Pathway Involved in Cervical Tumorigenesis.,2025,10.1002/jcp.31516,https://pubmed.ncbi.nlm.nih.gov/39749722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,38372748,KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.,2024,10.1007/s00018-024-05114-5,https://pubmed.ncbi.nlm.nih.gov/38372748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,41218610,KIF18A promotes chromosome congression in cooperation with CENP-E downstream of CENP-C.,2025,10.1016/j.celrep.2025.116515,https://pubmed.ncbi.nlm.nih.gov/41218610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,42894563,In silico insights into shared molecular mechanisms and drug repurposing for non‑small cell lung cancer and tuberculosis.,2026,10.1007/s40203-026-00767-5,https://pubmed.ncbi.nlm.nih.gov/42894563/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,41543111,KIF18A inhibition and its rising role in cancer therapy trials: from bench to bedside.,2026,10.1080/13543784.2026.2616752,https://pubmed.ncbi.nlm.nih.gov/41543111/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,39937284,Identification of the entosis-related prognostic signature and tumour microenvironment in hepatocellular carcinoma on the basis of bioinformatics analysis and experimental validation.,2025,10.1007/s10238-025-01580-8,https://pubmed.ncbi.nlm.nih.gov/39937284/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,42613365,Paediatric therapeutic development workshop on osteosarcoma.,2026,10.1038/s41416-026-03572-1,https://pubmed.ncbi.nlm.nih.gov/42613365/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,41975111,Identification of a novel platelet-related prognostic model for hepatocellular carcinoma.,2026,10.1007/s12672-026-04976-4,https://pubmed.ncbi.nlm.nih.gov/41975111/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,39168405,Exploration of inhibitors targeting KIF18A with ploidy-specific lethality.,2024,10.1016/j.drudis.2024.104142,https://pubmed.ncbi.nlm.nih.gov/39168405/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,40255404,Clinical potential and experimental validation of prognostic genes in hepatocellular carcinoma revealed by risk modeling utilizing single cell and transcriptome constructs.,2025,10.3389/fimmu.2025.1541252,https://pubmed.ncbi.nlm.nih.gov/40255404/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF18A,ENSG00000121621,Unsafe,42273677,Identification of a novel PANoptosis-associated prognostic signature and immune landscape analysis in neuroblastoma with experimental validation.,2026,10.3389/fimmu.2026.1853357,https://pubmed.ncbi.nlm.nih.gov/42273677/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,42462712,Targeting mitotic kinesin KIF20A: A differentiation-based therapeutic strategy for glioblastoma stem/progenitor cells.,2026,10.1016/j.stemcr.2026.103013,https://pubmed.ncbi.nlm.nih.gov/42462712/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,41646843,Targeting KIF20A: a new frontier in cancer treatment revealed by multi-omics analysis.,2026,10.3389/fimmu.2026.1744899,https://pubmed.ncbi.nlm.nih.gov/41646843/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,42483440,Unveiling immune-related gene signatures in triple negative breast cancer through integrated transcriptomic analysis.,2026,10.37796/2211-8039.1708,https://pubmed.ncbi.nlm.nih.gov/42483440/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,42426841,Large-scale transcriptome analysis reveals KIF20A as a novel indicator of cisplatin resistance in high-grade serous ovarian cancer.,2026,10.1186/s13048-026-02173-z,https://pubmed.ncbi.nlm.nih.gov/42426841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,41701424,KIF20A suppresses ferroptosis in HCC through HMOX1/SLC7A11/GPX4 signaling pathway.,2026,10.1007/s12672-026-04673-2,https://pubmed.ncbi.nlm.nih.gov/41701424/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,42216528,Kinesin KIF20A Regulated by ATF2 Transcription Promotes Prostate Cancer Proliferation and Invasion.,2026,10.31083/fbl48235,https://pubmed.ncbi.nlm.nih.gov/42216528/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,41776329,KIF20A promotes cervical cancer progression by interacting with CLIP1.,2026,10.1038/s41598-026-42883-4,https://pubmed.ncbi.nlm.nih.gov/41776329/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,41714472,FOXK1 induced upregulation of KIF20A promotes hepatocellular carcinoma progression via Wnt/β-Catenin/EMT signaling.,2026,10.1007/s00018-026-06131-2,https://pubmed.ncbi.nlm.nih.gov/41714472/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,42381127,KIF20A in Human Malignancies: Oncogenic Mechanisms and Therapeutic Targeting Strategies.,2026,10.2174/0113895575441637260522044015,https://pubmed.ncbi.nlm.nih.gov/42381127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,41672965,"KIF20A inhibits TRIM21-dependent ubiquitination of DHX9 to boost SOX2 stability, enhancing OSCC stemness and ferroptosis resistance.",2026,10.1038/s41419-026-08467-w,https://pubmed.ncbi.nlm.nih.gov/41672965/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,41267030,KIF20A as a driver of anti-PD-1 resistance via PD-L1 downregulation in NSCLC: a biomarker validation and tumor microenvironment analysis.,2025,10.1186/s12885-025-15221-6,https://pubmed.ncbi.nlm.nih.gov/41267030/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,41952973,Targeting KIF20A blocks lactylation modification to suppress immune escape in hepatocellular carcinoma.,2026,10.1016/j.isci.2026.115372,https://pubmed.ncbi.nlm.nih.gov/41952973/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,41713545,"KIF20A drives epithelial cell proliferation and migration in gastric adenocarcinoma, facilitating macrophage M2 polarization and subsequent immune evasion.",2026,10.1016/j.ijbiomac.2026.150982,https://pubmed.ncbi.nlm.nih.gov/41713545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,42437826,KIAA1429 promotes gallbladder cancer progression through m6A-dependent post-transcriptional modification of KIF20A.,2026,10.1038/s41598-026-61349-1,https://pubmed.ncbi.nlm.nih.gov/42437826/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,41266758,Crotonoside exerts anti-colorectal cancer effects by suppressing KIF20A to regulate the cell cycle.,2025,10.1038/s41598-025-24969-7,https://pubmed.ncbi.nlm.nih.gov/41266758/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,42309385,X-ray irradiation suppresses keloid growth by inducing G2/M arrest through the phytosphingosine-KIF20A axis.,2026,10.1016/j.jid.2026.06.1270,https://pubmed.ncbi.nlm.nih.gov/42309385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,42726806,Identification of functional genes and immune cell infiltration analysis in liposarcoma.,2026,10.1371/journal.pone.0358180,https://pubmed.ncbi.nlm.nih.gov/42726806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,42405025,Integrative Transcriptomic Analysis Identifies Hypoxia-responsive Cell Cycle Hub Genes as Prognostic Markers in Glioblastoma.,2026,10.1177/09727531261453688,https://pubmed.ncbi.nlm.nih.gov/42405025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,41462522,"Kinesin genes KIF4A, KIF20A and KIF11 as prognostic biomarkers in lung adenocarcinoma by integrative bioinformatic analysis and experimental validation.",2025,10.1038/s41598-025-29206-9,https://pubmed.ncbi.nlm.nih.gov/41462522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,40914946,Hypoxia Triggers ALYREF-Mediated m&lt;sup&gt;5&lt;/sup&gt;C Methylation of KIF20A to Activate KIF20A/BUB1 for Generating Ferroptosis Resistance in Cervical Cancer Cells.,2026,10.1002/kjm2.70093,https://pubmed.ncbi.nlm.nih.gov/40914946/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,41937416,Lactate drives immune resistance &lt;i&gt;via&lt;/i&gt; a pharmaceutically reversible H3K18la-KIF20A-c-Myc-PD-L1 axis in hepatocellular carcinoma.,2026,10.20892/j.issn.2095-3941.2026.0110,https://pubmed.ncbi.nlm.nih.gov/41937416/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,39272816,Advancing Cancer Therapy: The Role of KIF20A as a Target for Inhibitor Development and Immunotherapy.,2024,10.3390/cancers16172958,https://pubmed.ncbi.nlm.nih.gov/39272816/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,42685023,Identification of a cholesterol metabolism-related signature based on KIF20A and NDC80 for prognostic stratification and immunotherapy prediction in hepatocellular carcinoma.,2026,10.1177/18758592261479725,https://pubmed.ncbi.nlm.nih.gov/42685023/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,42529891,Kinesins in Bladder Cancer: Integrating Molecular Mechanisms and Treatment Approaches.,2026,10.1002/cbin.70191,https://pubmed.ncbi.nlm.nih.gov/42529891/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,42144083,Prognostic significance and therapeutic implications of migrasome-related genes in Sorafenib treatment for primary liver cancer.,2026,10.1016/j.ejps.2026.107557,https://pubmed.ncbi.nlm.nih.gov/42144083/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,40896909,PHLA-SiNet: A novel peptide-HLA binding prediction model using heterogeneous Siamese neural networks.,2025,10.1016/j.compbiomed.2025.111017,https://pubmed.ncbi.nlm.nih.gov/40896909/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,39753573,A KIF20A-based thermosensitive hydrogel vaccine effectively potentiates immune checkpoint blockade therapy for hepatocellular carcinoma.,2025,10.1038/s41541-024-01060-2,https://pubmed.ncbi.nlm.nih.gov/39753573/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,41578512,Ferroptosis-related gene signature predicts prognosis and immunotherapy response in hepatocellular carcinoma: A multi-cohort retrospective study.,2026,10.1097/md.0000000000047262,https://pubmed.ncbi.nlm.nih.gov/41578512/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,41392981,Targeting kinesin family member 20A sensitizes stem-like triple-negative breast cancer cells to standard chemotherapy.,2025,10.1172/jci182394,https://pubmed.ncbi.nlm.nih.gov/41392981/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20A,ENSG00000112984,Unsafe,39555078,Bulk- and single cell-RNA sequencing reveal KIF20A as a key driver of hepatocellular carcinoma progression and immune evasion.,2024,10.3389/fimmu.2024.1469827,https://pubmed.ncbi.nlm.nih.gov/39555078/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,42897663,"Exome-wide association study reveals common and rare coding variants shaping chronic pain in 327,642 UK biobank participants.",2026,10.1186/s13073-026-01732-9,https://pubmed.ncbi.nlm.nih.gov/42897663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,42449958,Exploratory LC-MS/MS-Based Proteomic and Lipidomic Profiling of Plasma Samples from Premature Coronary Artery Disease Patients: A Pilot Study in a South Asian Population.,2026,10.3390/ijms27135684,https://pubmed.ncbi.nlm.nih.gov/42449958/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,41650824,Characterizing two subtypes of osteosarcoma using G2M checkpoint-related genes and revealing its immune landscape.,2026,10.1016/j.molimm.2026.01.014,https://pubmed.ncbi.nlm.nih.gov/41650824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,40229707,Inhibition of miR-325 inhibits KIF20B expression and the colorectal cancer cells' invasion &amp; proliferation.,2025,10.1186/s12885-025-13759-z,https://pubmed.ncbi.nlm.nih.gov/40229707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,38426627,Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer.,2024,10.3892/ijo.2024.5631,https://pubmed.ncbi.nlm.nih.gov/38426627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,40348995,Porphyromonas gingivalis outer membrane vesicles augments proliferation and metastasis of oral squamous cell carcinoma cells.,2025,10.1186/s12903-025-05937-z,https://pubmed.ncbi.nlm.nih.gov/40348995/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,38599670,Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus.,2024,10.1136/lupus-2023-001139,https://pubmed.ncbi.nlm.nih.gov/38599670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,38305288,KIF20B Correlates with LUAD Progression and Is an Independent Risk Factor.,2024,10.1615/critreveukaryotgeneexpr.2023050271,https://pubmed.ncbi.nlm.nih.gov/38305288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,39237897,SEPT9: From pan-cancer to lung squamous cell carcinoma.,2024,10.1186/s12885-024-12877-4,https://pubmed.ncbi.nlm.nih.gov/39237897/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,39368370,Comprehensive proteomics analysis reveals novel Nek2-regulated pathways and therapeutic targets in cancer.,2024,10.1016/j.bbrc.2024.150779,https://pubmed.ncbi.nlm.nih.gov/39368370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,38266456,"KIF20B and MET, hub genes of DIAPHs, predict poor prognosis and promote pancreatic cancer progression.",2024,10.1016/j.prp.2023.155046,https://pubmed.ncbi.nlm.nih.gov/38266456/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,37102216,Anti-KIF20B autoantibodies in systemic autoimmune rheumatic diseases: Their high prevalence in systemic lupus erythematosus.,2023,10.1111/1346-8138.16813,https://pubmed.ncbi.nlm.nih.gov/37102216/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,40273626,"Vitamin K2 mitigates cognitive, and motor impairments induced by multiple surgery with anesthesia and analgesia in neonatal stage.",2025,10.1016/j.bbrc.2025.151784,https://pubmed.ncbi.nlm.nih.gov/40273626/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,34065612,"Cancer Testis Antigen, NOL4, Is an Immunogenic Antigen Specifically Expressed in Small-Cell Lung Cancer.",2021,10.3390/curroncol28030179,https://pubmed.ncbi.nlm.nih.gov/34065612/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,30304535,p53 deletion rescues lethal microcephaly in a mouse model with neural stem cell abscission defects.,2019,10.1093/hmg/ddy350,https://pubmed.ncbi.nlm.nih.gov/30304535/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,34539784,KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer.,2021,10.1155/2021/5572402,https://pubmed.ncbi.nlm.nih.gov/34539784/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,37974198,"Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.",2023,10.1186/s12964-023-01335-6,https://pubmed.ncbi.nlm.nih.gov/37974198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,31260385,A Monoclonal Antibody to M-Phase Phosphoprotein 1/Kinesin-Like Protein KIF20B.,2019,10.1089/mab.2019.0016,https://pubmed.ncbi.nlm.nih.gov/31260385/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,35719406,Case Report: Balanced Reciprocal Translocation t (17; 22) (p11.2; q11.2) and 10q23.31 Microduplication in an Infertile Male Patient Suffering From Teratozoospermia.,2022,10.3389/fgene.2022.797813,https://pubmed.ncbi.nlm.nih.gov/35719406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,30191636,Inhibition of kinesin family member 20B sensitizes hepatocellular carcinoma cell to microtubule-targeting agents by blocking cytokinesis.,2018,10.1111/cas.13794,https://pubmed.ncbi.nlm.nih.gov/30191636/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,38203311,An Integrated Multi-Omics Analysis Identifying Immune Subtypes of Pancreatic Cancer.,2023,10.3390/ijms25010142,https://pubmed.ncbi.nlm.nih.gov/38203311/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,29971464,Immunotherapy with cancer peptides in combination with intravesical bacillus Calmette-Guerin for patients with non-muscle invasive bladder cancer.,2018,10.1007/s00262-018-2197-x,https://pubmed.ncbi.nlm.nih.gov/29971464/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,38993370,A Phase 2 Study of S-588410 Maintenance Monotherapy for Platinum-Treated Advanced or Metastatic Urothelial Carcinoma.,2022,10.3233/blc-211592,https://pubmed.ncbi.nlm.nih.gov/38993370/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,29632734,Bladder cancer-associated cancer-testis antigen-derived long peptides encompassing both CTL and promiscuous HLA class II-restricted Th cell epitopes induced CD4+ T cells expressing converged T-cell receptor genes in vitro.,2018,10.1080/2162402x.2017.1415687,https://pubmed.ncbi.nlm.nih.gov/29632734/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,32500232,Exploratory open-label clinical study to determine the S-588410 cancer peptide vaccine-induced tumor-infiltrating lymphocytes and changes in the tumor microenvironment in esophageal cancer patients.,2020,10.1007/s00262-020-02619-3,https://pubmed.ncbi.nlm.nih.gov/32500232/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,30519350,Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor.,2018,10.7150/jca.25279,https://pubmed.ncbi.nlm.nih.gov/30519350/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,37255411,Overlaid Transcriptional and Proteome Analyses Identify Mitotic Kinesins as Important Targets of Arylsulfonamide-Mediated RBM39 Degradation.,2023,10.1158/1541-7786.mcr-22-0541,https://pubmed.ncbi.nlm.nih.gov/37255411/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,34557409,Identification of Novel Molecular Therapeutic Targets and Their Potential Prognostic Biomarkers Among Kinesin Superfamily of Proteins in Pancreatic Ductal Adenocarcinoma.,2021,10.3389/fonc.2021.708900,https://pubmed.ncbi.nlm.nih.gov/34557409/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,38584208,The transcriptomic signature of respiratory sensitizers using an alveolar model.,2024,10.1007/s10565-024-09860-x,https://pubmed.ncbi.nlm.nih.gov/38584208/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,38268915,Exploring KRAS-mutant pancreatic ductal adenocarcinoma: a model validation study.,2023,10.3389/fimmu.2023.1203459,https://pubmed.ncbi.nlm.nih.gov/38268915/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,31403911,"Monoclonal Antibody KIF20B(10C7), MPP1.",2019,10.1089/mab.2019.0029,https://pubmed.ncbi.nlm.nih.gov/31403911/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,36061171,Integrating cell cycle score for precise risk stratification in ovarian cancer.,2022,10.3389/fgene.2022.958092,https://pubmed.ncbi.nlm.nih.gov/36061171/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,27998971,A phase I/II study of cancer peptide vaccine S-288310 in patients with advanced urothelial carcinoma of the bladder.,2017,10.1093/annonc/mdw675,https://pubmed.ncbi.nlm.nih.gov/27998971/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,17409436,"Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer.",2007,10.1158/0008-5472.can-06-3748,https://pubmed.ncbi.nlm.nih.gov/17409436/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF20B,ENSG00000138182,Unsafe,12740395,M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis.,2003,10.1074/jbc.m304522200,https://pubmed.ncbi.nlm.nih.gov/12740395/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,42557021,Exploratory Transcriptomic Profiling of Vein Tissue from Diabetic Patients Undergoing Arteriovenous Fistula Creation for Hemodialysis.,2026,10.5551/jat.66048,https://pubmed.ncbi.nlm.nih.gov/42557021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,35803737,KIF24 depletion induces clustering of supernumerary centrosomes in PDAC cells.,2022,10.26508/lsa.202201470,https://pubmed.ncbi.nlm.nih.gov/35803737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,35748595,Biallelic KIF24 Variants Are Responsible for a Spectrum of Skeletal Disorders Ranging From Lethal Skeletal Ciliopathy to Severe Acromesomelic Dysplasia.,2022,10.1002/jbmr.4639,https://pubmed.ncbi.nlm.nih.gov/35748595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,38137010,Optical Genome Mapping Helps to Identify BCR::JAK2 Rearrangement Arising from Cryptic Complex Chromosomal Aberrations: A Case Report and Literature Review.,2023,10.3390/genes14122188,https://pubmed.ncbi.nlm.nih.gov/38137010/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,37809716,Integrative analysis of cancer-associated fibroblast signature in gastric cancer.,2023,10.1016/j.heliyon.2023.e19217,https://pubmed.ncbi.nlm.nih.gov/37809716/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,36619972,Identifying biomarkers of differential chemotherapy response in TNBC patient-derived xenografts with a CTD/WGCNA approach.,2023,10.1016/j.isci.2022.105799,https://pubmed.ncbi.nlm.nih.gov/36619972/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,37238607,Epigenetic and Tumor Microenvironment for Prognosis of Patients with Gastric Cancer.,2023,10.3390/biom13050736,https://pubmed.ncbi.nlm.nih.gov/37238607/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,34148545,Identification of sixteen novel candidate genes for late onset Parkinson's disease.,2021,10.1186/s13024-021-00455-2,https://pubmed.ncbi.nlm.nih.gov/34148545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,32322170,Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer.,2020,10.1186/s12935-020-01191-1,https://pubmed.ncbi.nlm.nih.gov/32322170/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,26290419,Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle.,2015,10.1038/ncomms9087,https://pubmed.ncbi.nlm.nih.gov/26290419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,30375385,M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole.,2018,10.1038/s41467-018-06990-9,https://pubmed.ncbi.nlm.nih.gov/30375385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,34298439,Driver and novel genes correlated with metastasis of non-small cell lung cancer: A comprehensive analysis.,2021,10.1016/j.prp.2021.153551,https://pubmed.ncbi.nlm.nih.gov/34298439/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,32636717,The plasma peptides of sepsis.,2020,10.1186/s12014-020-09288-5,https://pubmed.ncbi.nlm.nih.gov/32636717/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,27716277,Array-CGH diagnosis in ovarian failure: identification of new molecular actors for ovarian physiology.,2016,10.1186/s13048-016-0272-5,https://pubmed.ncbi.nlm.nih.gov/27716277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,26719793,Current topics of functional links between primary cilia and cell cycle.,2015,10.1186/s13630-015-0021-1,https://pubmed.ncbi.nlm.nih.gov/26719793/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,21663786,A kinesin in command of primary ciliogenesis.,2011,10.1016/j.cell.2011.05.023,https://pubmed.ncbi.nlm.nih.gov/21663786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,29081410,Whole-exome sequencing to identify novel mutations of nevoid basal cell carcinoma syndrome in a Chinese population.,2017,10.3233/cbm-170541,https://pubmed.ncbi.nlm.nih.gov/29081410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,22365849,"Klp10A, a microtubule-depolymerizing kinesin-13, cooperates with CP110 to control Drosophila centriole length.",2012,10.1016/j.cub.2012.01.046,https://pubmed.ncbi.nlm.nih.gov/22365849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,24391143,"Kinesin family deregulation coordinated by bromodomain protein ANCCA and histone methyltransferase MLL for breast cancer cell growth, survival, and tamoxifen resistance.",2014,10.1158/1541-7786.mcr-13-0459,https://pubmed.ncbi.nlm.nih.gov/24391143/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF24,ENSG00000186638,Unsafe,21124853,The expanded Kinesin-13 repertoire of trypanosomes contains only one mitotic Kinesin indicating multiple extra-nuclear roles.,2010,10.1371/journal.pone.0015020,https://pubmed.ncbi.nlm.nih.gov/21124853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,41071932,KIF2A downregulation links amyloid-β to Tau phosphorylation in Alzheimer's disease.,2026,10.1093/brain/awaf382,https://pubmed.ncbi.nlm.nih.gov/41071932/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,42257979,Dysregulated KIF2A correlates with p53 expression pattern in breast cancer.,2026,10.1007/s11010-026-05589-9,https://pubmed.ncbi.nlm.nih.gov/42257979/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,42636674,Consensus subtypes and a generalizable prognostic signature defined by an R-loop score in hepatocellular carcinoma: Multi-omics analyses pinpoint KIF2A-positive proliferative tumor cells.,2026,10.1016/j.prp.2026.156656,https://pubmed.ncbi.nlm.nih.gov/42636674/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,41591845,KIF2A-mediated microtubule-dependent nuclear envelope invagination drives nonhomologous end joining.,2026,10.1093/nar/gkag004,https://pubmed.ncbi.nlm.nih.gov/41591845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,42651835,Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders.,2026,10.3390/cimb48080837,https://pubmed.ncbi.nlm.nih.gov/42651835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,40735840,Long-read RNA-sequencing reveals transcript-specific regulation in human-derived cortical neurons.,2025,10.1098/rsob.250200,https://pubmed.ncbi.nlm.nih.gov/40735840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,40353778,KIF2A stabilizes intercellular bridge microtubules to maintain mouse embryonic stem cell cytokinesis.,2025,10.1083/jcb.202409157,https://pubmed.ncbi.nlm.nih.gov/40353778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,39206808,Loss of Smek1 Induces Tauopathy and Triggers Neurodegeneration by Regulating Microtubule Stability.,2024,10.1002/advs.202400584,https://pubmed.ncbi.nlm.nih.gov/39206808/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,38534420,KIF2A Upregulates PI3K/AKT Signaling through Polo-like Kinase 1 (PLK1) to Affect the Proliferation and Apoptosis Levels of Eriocheir sinensis Spermatogenic Cells.,2024,10.3390/biology13030149,https://pubmed.ncbi.nlm.nih.gov/38534420/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,40302551,Crystal structures of Kif2A complexed with WDR5 reveal the structural plasticity of WIN-S7 sites.,2025,10.3724/abbs.2025066,https://pubmed.ncbi.nlm.nih.gov/40302551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,40213390,KIF2C is essential for meiosis and manchette dynamics in male mice.,2025,10.3389/fcell.2025.1523593,https://pubmed.ncbi.nlm.nih.gov/40213390/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,38974111,"KIF2A correlates with lymphovascular invasion and higher tumor stage, and can be used to predict worse prognosis in patients with endometrial carcinoma.",2024,10.3892/ol.2024.14529,https://pubmed.ncbi.nlm.nih.gov/38974111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,41210694,"Exploring the Glycolytic Mechanisms in ""Driver Gene-Negative"" Lung Adenocarcinoma (LUAD): A Single-Cell RNA Sequencing Approach to Identify the MIF-HIF-1α Axis.",2025,10.7150/jca.119149,https://pubmed.ncbi.nlm.nih.gov/41210694/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,42917548,Mechanisms of Stability of the Metaphase Spindle and Associated Proteins Regulating Microtubule Flux.,2026,10.1021/acs.jpcb.6c04388,https://pubmed.ncbi.nlm.nih.gov/42917548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,39640087,APC orchestrates microtubule dynamics by acting as a positive regulator of KIF2A and a negative regulator of CLASPs.,2025,10.1016/j.cellin.2024.100210,https://pubmed.ncbi.nlm.nih.gov/39640087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,36343267,KIF2A deficiency causes early-onset neurodegeneration.,2022,10.1073/pnas.2209714119,https://pubmed.ncbi.nlm.nih.gov/36343267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,39930500,Tau-tubulin kinase 2 restrains microtubule-depolymerizer KIF2A to support primary cilia growth.,2025,10.1186/s12964-025-02072-8,https://pubmed.ncbi.nlm.nih.gov/39930500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,39587911,Hsa_circ_0088036 promotes tumorigenesis and chemotherapy resistance in hepatocellular carcinoma via the miR-140-3p/KIF2A axis.,2025,10.14670/hh-18-849,https://pubmed.ncbi.nlm.nih.gov/39587911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,38028961,Multi-omics prognostic signatures of IPO11 mRNA expression and clinical outcomes in colorectal cancer using bioinformatics approaches.,2023,10.1007/s13755-023-00259-2,https://pubmed.ncbi.nlm.nih.gov/38028961/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,40893312,Genome-Wide Identification of Microglia-Related RNA-Binding Proteins and Regulated Alternative Splicing in Spinal Cord Injury.,2025,10.1021/acsomega.5c03477,https://pubmed.ncbi.nlm.nih.gov/40893312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,31725680,Prognostic significance of KIF2A and KIF20A expression in human cancer: A systematic review and meta-analysis.,2019,10.1097/md.0000000000018040,https://pubmed.ncbi.nlm.nih.gov/31725680/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,36277155,KIF2A participates in the progression of hepatocellular carcinoma and angiogenesis by interacting with Notch1.,2022,10.3892/etm.2022.11619,https://pubmed.ncbi.nlm.nih.gov/36277155/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,36793588,Characterization of Infiltrating Immune Cells and Secretory or Membrane-Associated Proteins in KRAS Lung Adenocarcinoma.,2023,10.1155/2023/4987832,https://pubmed.ncbi.nlm.nih.gov/36793588/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,36797232,RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling.,2023,10.1038/s41368-023-00216-5,https://pubmed.ncbi.nlm.nih.gov/36797232/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,35313389,"Kinesin family member 2A links with advanced tumor stage, reduced chemosensitivity and worse prognosis in gastric cancer.",2022,10.1002/jcla.24313,https://pubmed.ncbi.nlm.nih.gov/35313389/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,34404749,Modeling Neurodevelopmental Disorders and Epilepsy Caused by Loss of Function of kif2a in Zebrafish.,2021,10.1523/eneuro.0055-21.2021,https://pubmed.ncbi.nlm.nih.gov/34404749/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,34017375,"Kinesin family member 2A promotes cancer cell viability, mobility, stemness, and chemoresistance to cisplatin by activating the PI3K/AKT/VEGF signaling pathway in non-small cell lung cancer.",2021,,https://pubmed.ncbi.nlm.nih.gov/34017375/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,36420308,Potential blood biomarkers for chronic traumatic encephalopathy: The multi-omics landscape of an observational cohort.,2022,10.3389/fnagi.2022.1052765,https://pubmed.ncbi.nlm.nih.gov/36420308/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,34396686,Mechanical Stimulation after Centrifuge-Free Nano-Electroporative Transfection Is Efficient and Maintains Long-Term T Cell Functionalities.,2021,10.1002/smll.202103198,https://pubmed.ncbi.nlm.nih.gov/34396686/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,31919497,Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny.,2020,10.1093/hmg/ddz316,https://pubmed.ncbi.nlm.nih.gov/31919497/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,34827689,Screening Plasma Exosomal RNAs as Diagnostic Markers for Cervical Cancer: An Analysis of Patients Who Underwent Primary Chemoradiotherapy.,2021,10.3390/biom11111691,https://pubmed.ncbi.nlm.nih.gov/34827689/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,34527595,Identification of Glycolysis-Related lncRNAs and the Novel lncRNA WAC-AS1 Promotes Glycolysis and Tumor Progression in Hepatocellular Carcinoma.,2021,10.3389/fonc.2021.733595,https://pubmed.ncbi.nlm.nih.gov/34527595/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,26323509,Increased expression of surface CD44 in hypoxia-DCs skews helper T cells toward a Th2 polarization.,2015,10.1038/srep13674,https://pubmed.ncbi.nlm.nih.gov/26323509/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2A,ENSG00000068796,Unsafe,33029143,A Novel Prognostic Index Based on the Analysis of Glycolysis-Related Genes in Head and Neck Squamous Cell Carcinomas.,2020,10.1155/2020/7353874,https://pubmed.ncbi.nlm.nih.gov/33029143/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,40213390,KIF2C is essential for meiosis and manchette dynamics in male mice.,2025,10.3389/fcell.2025.1523593,https://pubmed.ncbi.nlm.nih.gov/40213390/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,42504935,Disentangling Sex Differences in Sulfonylurea Drug Response With Genome-Wide Association Studies in Individuals With Type 2 Diabetes.,2026,10.1002/cpt.70381,https://pubmed.ncbi.nlm.nih.gov/42504935/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,35866054,KIF26B Is Overexpressed in Medulloblastoma and Promotes Malignant Progression by Activating the PI3K/AKT Pathway.,2022,10.1155/2022/2552397,https://pubmed.ncbi.nlm.nih.gov/35866054/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,34067543,α-Fodrin in Cytoskeletal Organization and the Activity of Certain Key Microtubule Kinesins.,2021,10.3390/genes12050750,https://pubmed.ncbi.nlm.nih.gov/34067543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,34368969,SCFFbxw5 targets kinesin-13 proteins to facilitate ciliogenesis.,2021,10.15252/embj.2021107735,https://pubmed.ncbi.nlm.nih.gov/34368969/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,31179849,Chromosomal instability suppresses the growth of K-Ras-induced lung adenomas.,2019,10.1080/15384101.2019.1629790,https://pubmed.ncbi.nlm.nih.gov/31179849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,30362892,Expression analysis of a panel of cancer-testis antigens in bladder cancer.,2018,10.2217/pme-2018-0049,https://pubmed.ncbi.nlm.nih.gov/30362892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,32017920,A Genetic Toggle for Chemical Control of Individual Plk1 Substrates.,2020,10.1016/j.chembiol.2020.01.007,https://pubmed.ncbi.nlm.nih.gov/32017920/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,27375225,"Expression of dynein, cytoplasmic 2, heavy chain 1 (DHC2) associated with glioblastoma cell resistance to temozolomide.",2016,10.1038/srep28948,https://pubmed.ncbi.nlm.nih.gov/27375225/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,27982129,Phosphorylation of SKAP by GSK3β ensures chromosome segregation by a temporal inhibition of Kif2b activity.,2016,10.1038/srep38791,https://pubmed.ncbi.nlm.nih.gov/27982129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,23087211,The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle.,2012,10.1091/mbc.e12-03-0214,https://pubmed.ncbi.nlm.nih.gov/23087211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,22535524,Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation.,2012,10.1091/mbc.e11-12-1013,https://pubmed.ncbi.nlm.nih.gov/22535524/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,25568341,Kif2a depletion generates chromosome segregation and pole coalescence defects in animal caps and inhibits gastrulation of the Xenopus embryo.,2015,10.1091/mbc.e13-12-0721,https://pubmed.ncbi.nlm.nih.gov/25568341/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,26656453,Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis.,2015,10.1038/ncomms10072,https://pubmed.ncbi.nlm.nih.gov/26656453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,20852589,"CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity.",2010,10.1038/emboj.2010.230,https://pubmed.ncbi.nlm.nih.gov/20852589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,25074805,STAG2 promotes error correction in mitosis by regulating kinetochore-microtubule attachments.,2014,10.1242/jcs.151613,https://pubmed.ncbi.nlm.nih.gov/25074805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,26870257,Nine susceptibility loci for hepatitis B virus-related hepatocellular carcinoma identified by a pilot two-stage genome-wide association study.,2016,10.3892/ol.2015.3958,https://pubmed.ncbi.nlm.nih.gov/26870257/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,19060894,Genome stability is ensured by temporal control of kinetochore-microtubule dynamics.,2009,10.1038/ncb1809,https://pubmed.ncbi.nlm.nih.gov/19060894/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,23554873,Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity.,2013,10.1371/journal.pone.0058048,https://pubmed.ncbi.nlm.nih.gov/23554873/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2B,ENSG00000141200,Unsafe,17538014,"The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.",2007,10.1091/mbc.e07-02-0110,https://pubmed.ncbi.nlm.nih.gov/17538014/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,42602724,The deficiency of KIF2C leads to abnormal distribution of cortical neurons and behavioral deficits in mice.,2026,10.1016/j.isci.2026.117069,https://pubmed.ncbi.nlm.nih.gov/42602724/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,42256274,MCAK/Kif2C centromeric activity level tunes K-fiber turnover through distinct pathways.,2026,10.1016/j.isci.2026.116122,https://pubmed.ncbi.nlm.nih.gov/42256274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,40213390,KIF2C is essential for meiosis and manchette dynamics in male mice.,2025,10.3389/fcell.2025.1523593,https://pubmed.ncbi.nlm.nih.gov/40213390/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,40433108,KIF2C Deletion Causes Meiotic Abnormalities and Nonobstructive Azoospermia in Mice.,2025,10.1002/rmb2.12659,https://pubmed.ncbi.nlm.nih.gov/40433108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,40292920,Elevated KIF2C Expression Drives Osteosarcoma Progression by Modulating the Wnt/β-Catenin Signaling Pathway and Contributing to an Immunosuppressive Tumor Microenvironment.,2025,10.1002/cam4.70915,https://pubmed.ncbi.nlm.nih.gov/40292920/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,41986639,Early detection of oral squamous cell carcinoma using five tumor-associated autoantibodies and a Naive Bayes-based machine learning model.,2026,10.1038/s41598-026-48821-8,https://pubmed.ncbi.nlm.nih.gov/41986639/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,41037059,&lt;i&gt;miR-4484&lt;/i&gt; suppresses hepatocellular carcinoma progression via targeting &lt;i&gt;KIF2C&lt;/i&gt;.,2025,10.1080/15476286.2025.2569192,https://pubmed.ncbi.nlm.nih.gov/41037059/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,40517212,HNF4A promotes tumor progression in gastric cancer by transcriptional activation of KIF2C.,2025,10.1007/s10238-025-01748-2,https://pubmed.ncbi.nlm.nih.gov/40517212/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,41191207,Identification of lactylation-related biomarkers in HNSC by integrating machine learning and Spatial transcriptomics analysis.,2025,10.1007/s12672-025-03849-6,https://pubmed.ncbi.nlm.nih.gov/41191207/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,42792641,"Rewiring of Molecular Networks Induced by the Combination of Loratadine, Raloxifene, and Sorafenib Leads to the Identification of Clinically Relevant Therapeutic Targets in Hepatocellular Carcinoma.",2026,10.3390/biomedicines14091898,https://pubmed.ncbi.nlm.nih.gov/42792641/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,41908151,Exploring prognostic genes related to lactylation and programmed cell death in pancreatic ductal adenocarcinoma: a comprehensive study combining bulk transcriptomics and experimental verification.,2026,10.3389/fgene.2026.1774953,https://pubmed.ncbi.nlm.nih.gov/41908151/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,41038601,KIF2C regulates macrophage M2 polarization and DLBCL progression by regulating the STAT3/IL-10 axis.,2025,10.1016/j.cellsig.2025.112155,https://pubmed.ncbi.nlm.nih.gov/41038601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,42500733,Delafloxacin suppresses DEPDC1 expression and induces G2/M arrest in non-small cell lung cancer cells: A drug repurposing study.,2026,10.1002/smo2.70050,https://pubmed.ncbi.nlm.nih.gov/42500733/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,42714711,AKR7A3 rs1738023 association with susceptibility to female hepatocellular carcinoma and its role in AFB1 metabolism and tumor.,2026,10.1007/s12672-026-05757-9,https://pubmed.ncbi.nlm.nih.gov/42714711/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,41284119,The analysis of TOP2A as a potential target for predicting the prognosis of brain glioma in the TCGA database and in single-center study.,2025,10.1007/s12672-025-04051-4,https://pubmed.ncbi.nlm.nih.gov/41284119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,41937877,A competing TMPO-AS1-let-7b-5p-kinesin superfamily RNA network predicts poor lung cancer patient survival.,2026,10.5603/rpor.108659,https://pubmed.ncbi.nlm.nih.gov/41937877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,41341805,A Machine Learning-Derived Taurine Metabolism Signature Predicts Prognosis and Immune Landscape in Lung Adenocarcinoma via Integrative Single-Cell Analysis.,2025,10.1155/mi/6610564,https://pubmed.ncbi.nlm.nih.gov/41341805/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,38344808,"KIF2C/MCAK a prognostic biomarker and its oncogenic potential in malignant progression, and prognosis of cancer patients: a systematic review and meta-analysis as biomarker.",2024,10.1080/10408363.2024.2309933,https://pubmed.ncbi.nlm.nih.gov/38344808/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,40744233,USP36 suppresses breast cancer cell ferroptosis by regulating the ubiquitination and stability of KIF2C.,2025,10.1016/j.bcp.2025.117196,https://pubmed.ncbi.nlm.nih.gov/40744233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,41323394,Machine learning-based identification of core regulatory genes in hepatocellular carcinoma: insights from lactylation modification and liver regeneration-related genes.,2025,10.3389/fonc.2025.1683704,https://pubmed.ncbi.nlm.nih.gov/41323394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,40715580,The role of glucocorticoids in hepatocellular carcinoma through integrated bioinformatics analysis and experimental validation.,2025,10.1038/s41598-025-12839-1,https://pubmed.ncbi.nlm.nih.gov/40715580/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,38940931,KIF2C as a potential therapeutic target: insights from lung adenocarcinoma subtype classification and functional experiments.,2024,10.1039/d4mo00044g,https://pubmed.ncbi.nlm.nih.gov/38940931/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,41333555,Consensus Integration of Multiomics Data With Machine Learning Algorithms Reveals Heterogeneous Molecular Subtypes and Enables Personalized Treatment Strategies for Hepatocellular Carcinoma.,2025,10.1155/humu/9967779,https://pubmed.ncbi.nlm.nih.gov/41333555/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,42797298,"Protein Expression Dynamics in Breast Cancer Cells Exposed to Nano-Encapsulated Tarin, the Taro Lectin.",2026,10.3390/pharmaceutics18091123,https://pubmed.ncbi.nlm.nih.gov/42797298/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,37969406,Identification of tumor antigens and immune subtypes of hepatocellular carcinoma for mRNA vaccine development.,2023,10.4251/wjgo.v15.i10.1717,https://pubmed.ncbi.nlm.nih.gov/37969406/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,41035644,Deciphering the lactylation landscape in glioma: a novel gene signature predicts patient survival and immunotherapy sensitivity.,2025,10.3389/fimmu.2025.1664347,https://pubmed.ncbi.nlm.nih.gov/41035644/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,37016301,KIF2C is a prognostic biomarker associated with immune cell infiltration in breast cancer.,2023,10.1186/s12885-023-10788-4,https://pubmed.ncbi.nlm.nih.gov/37016301/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,41431383,An integrated microfluidic system for automated extraction of &lt;i&gt;in vitro&lt;/i&gt; transcribed mRNAs &lt;i&gt;via&lt;/i&gt; probe-coated magnetic beads.,2026,10.1039/d5lc00938c,https://pubmed.ncbi.nlm.nih.gov/41431383/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,12383881,"Expression of a novel HsMCAK mRNA splice variant, tsMCAK gene, in human testis.",2002,10.1016/s0024-3205(02)02079-9,https://pubmed.ncbi.nlm.nih.gov/12383881/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF2C,ENSG00000142945,Unsafe,9434124,Cloning and expression of human mitotic centromere-associated kinesin gene.,1997,10.1016/s0167-4889(97)00103-1,https://pubmed.ncbi.nlm.nih.gov/9434124/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,42725385,KIF4A drives esophageal squamous cell carcinoma via Wnt/β‑catenin signaling and predicts poor prognosis.,2026,10.3892/mmr.2026.14013,https://pubmed.ncbi.nlm.nih.gov/42725385/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,42251143,Low KIF4A expression is associated with gastric cancer progression and aggressive phenotypes.,2026,10.1038/s41598-026-56572-9,https://pubmed.ncbi.nlm.nih.gov/42251143/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,42010994,Physical exercise mitigates chronic psychological stress-induced vascular inflammation via the BDNF-Kif4-TARM1 axis.,2026,10.1002/ctm2.70674,https://pubmed.ncbi.nlm.nih.gov/42010994/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,42785594,KIF4A stabilizes TDP43 to promote DNA damage repair and temozolomide resistance in glioblastoma.,2026,10.1016/j.bcp.2026.118504,https://pubmed.ncbi.nlm.nih.gov/42785594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,41361459,KIF4A in disease pathogenesis and therapeutics: from molecular mechanisms to clinical translation.,2025,10.1186/s13062-025-00712-0,https://pubmed.ncbi.nlm.nih.gov/41361459/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,41816564,CPNE3 promotes colorectal cancer progression by regulating KIF4-mediated autophagy.,2026,10.21037/jgo-2025-735,https://pubmed.ncbi.nlm.nih.gov/41816564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,42512966,KIF4A-KIF4B Paralog as a Prognostic Biomarker in Lung Adenocarcinoma.,2026,10.3390/medicina62071424,https://pubmed.ncbi.nlm.nih.gov/42512966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,42171922,Identification of replication factor C subunit 4 as a potential therapeutic target in esophageal squamous cell carcinoma based on bioinformatic analysis and machine learning.,2026,10.1007/s12672-026-05254-z,https://pubmed.ncbi.nlm.nih.gov/42171922/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,41084153,KIF4A Promotes Glioblastoma Malignant Progression and Transmission of Temozolomide Resistance in the Tumor Microenvironment via the HIF1A/VEGFA Axis.,2025,10.1111/cns.70550,https://pubmed.ncbi.nlm.nih.gov/41084153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,41462522,"Kinesin genes KIF4A, KIF20A and KIF11 as prognostic biomarkers in lung adenocarcinoma by integrative bioinformatic analysis and experimental validation.",2025,10.1038/s41598-025-29206-9,https://pubmed.ncbi.nlm.nih.gov/41462522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,42464646,circCACNA1D drives pulmonary fibrosis by regulating pyruvate kinase M2 dimer‑tetramer switching.,2026,10.3892/ijmm.2026.5931,https://pubmed.ncbi.nlm.nih.gov/42464646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,40705827,KIF4A Inhibits Ferroptosis in Glioblastoma via the CHMP4B/GPX4 Axis and Promotes Temozolomide Resistance.,2025,10.1002/mc.70006,https://pubmed.ncbi.nlm.nih.gov/40705827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,42037647,Prognostic biomarkers and regulatory mechanisms associated with lysine β-hydroxybutyrylation modification in prostate cancer.,2026,10.3389/fmolb.2026.1778536,https://pubmed.ncbi.nlm.nih.gov/42037647/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,42529891,Kinesins in Bladder Cancer: Integrating Molecular Mechanisms and Treatment Approaches.,2026,10.1002/cbin.70191,https://pubmed.ncbi.nlm.nih.gov/42529891/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,41516135,Differentially Expressed Genes Associated with the Development of Cervical Cancer.,2025,10.3390/ijms27010258,https://pubmed.ncbi.nlm.nih.gov/41516135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,41937877,A competing TMPO-AS1-let-7b-5p-kinesin superfamily RNA network predicts poor lung cancer patient survival.,2026,10.5603/rpor.108659,https://pubmed.ncbi.nlm.nih.gov/41937877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,41667567,Retraction Note: KIF4A promotes tumor progression of bladder cancer via CXCL5 dependent myeloid-derived suppressor cells recruitment.,2026,10.1038/s41598-026-39297-7,https://pubmed.ncbi.nlm.nih.gov/41667567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,40557825,SP1-Mediated Upregulation of KIF4A Promotes Prostate Cancer Progression via Targeting TWIST1.,2025,10.1002/jbt.70378,https://pubmed.ncbi.nlm.nih.gov/40557825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,36606197,KIF4A drives gliomas growth by transcriptional repression of Rac1/Cdc42 to induce cytoskeletal remodeling in glioma cells.,2022,10.7150/jca.77238,https://pubmed.ncbi.nlm.nih.gov/36606197/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,42491333,A bioinformatics analysis of KIF transcriptomic subtyping reveals prognostic heterogeneity and differential therapeutic responses in cervical cancer.,2026,10.3892/ol.2026.15753,https://pubmed.ncbi.nlm.nih.gov/42491333/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,42459306,"ERCC6L in human cancers: oncogenic functions, molecular mechanisms, and clinical implications as a prognostic biomarker and therapeutic target.",2026,10.3389/fonc.2026.1812829,https://pubmed.ncbi.nlm.nih.gov/42459306/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,40456769,Multi-omics and AI-driven immune subtyping to optimize neoantigen-based vaccines for colorectal cancer.,2025,10.1038/s41598-025-01680-1,https://pubmed.ncbi.nlm.nih.gov/40456769/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,38357945,A Novel KIF4A-related Model for Predicting Immunotherapy Response and Prognosis in Kidney Renal Clear Cell Carcinoma.,2025,10.2174/0113862073296897240212114403,https://pubmed.ncbi.nlm.nih.gov/38357945/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,40523562,RXR agonist S169 inhibits HBV/HDV entry in vitro by disrupting KIF4-dependent NTCP trafficking.,2025,10.1016/j.antiviral.2025.106214,https://pubmed.ncbi.nlm.nih.gov/40523562/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,41704759,SeSA-HCPT: A dual-targeting agent that induces DNA damage and inhibits repair for castration-resistant prostate cancer therapy.,2026,10.1016/j.isci.2026.114824,https://pubmed.ncbi.nlm.nih.gov/41704759/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,41864930,A 13-gene prognostic model developed using machine learning to predict the response to neoadjuvant chemoradiotherapy in rectal carcinoma.,2026,10.1186/s12935-026-04256-9,https://pubmed.ncbi.nlm.nih.gov/41864930/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,36482480,KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway.,2023,10.1083/jcb.202208108,https://pubmed.ncbi.nlm.nih.gov/36482480/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,39354483,Decoding the immune microenvironment: unveiling CD8 + T cell-related biomarkers and developing a prognostic signature for personalized glioma treatment.,2024,10.1186/s12935-024-03517-9,https://pubmed.ncbi.nlm.nih.gov/39354483/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,40660314,Kinesin-related genes stratified the prognosis and immune responses of clear cell renal cell carcinoma.,2025,10.1186/s40001-025-02880-1,https://pubmed.ncbi.nlm.nih.gov/40660314/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,39665820,Injury-induced KIF4A neural expression and its role in Schwann cell proliferation suggest a dual function for this kinesin in neural regeneration.,2026,10.4103/nrr.nrr-d-24-00232,https://pubmed.ncbi.nlm.nih.gov/39665820/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,42441576,Reanalysis of Public Transcriptomes Reveals Shared Immune Signatures Between Major Depressive Disorder And Dermatomyositis With Single-Cell Context.,2026,10.3791/71024,https://pubmed.ncbi.nlm.nih.gov/42441576/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF4A,ENSG00000090889,Unsafe,10978527,"Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein.",2000,10.1016/s0167-4781(00)00151-2,https://pubmed.ncbi.nlm.nih.gov/10978527/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,42348434,The KIF6-RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly.,2026,10.1002/advs.76263,https://pubmed.ncbi.nlm.nih.gov/42348434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,39158699,Distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility.,2024,10.1083/jcb.202312060,https://pubmed.ncbi.nlm.nih.gov/39158699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,38235522,Motor protein Kif6 regulates cilia motility and polarity in brain ependymal cells.,2024,10.1242/dmm.050137,https://pubmed.ncbi.nlm.nih.gov/38235522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,39446171,Distinct roles of two homologous kinesins in mammalian motile cilia.,2024,10.1083/jcb.202409214,https://pubmed.ncbi.nlm.nih.gov/39446171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,40214644,Treatment of Pathological Lymphangiogenesis via Circular RNA-Mediated Cholesterol Metabolism Remodeling.,2025,10.1167/iovs.66.4.26,https://pubmed.ncbi.nlm.nih.gov/40214644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,36833179,KIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection.,2023,10.3390/genes14020252,https://pubmed.ncbi.nlm.nih.gov/36833179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,41009965,Association of Obesity-Related Genetic Variants with Android Fat Patterning and Cardiometabolic Risk in Women.,2025,10.3390/genes16091019,https://pubmed.ncbi.nlm.nih.gov/41009965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,37895049,A Comprehensive Genetic Study of Microtubule-Associated Gene Clusters for Male Infertility in a Taiwanese Cohort.,2023,10.3390/ijms242015363,https://pubmed.ncbi.nlm.nih.gov/37895049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,39251704,Two Tetrahymena kinesin-9 family members exhibit slow plus-end-directed motility in vitro.,2024,10.1038/s41598-024-71280-y,https://pubmed.ncbi.nlm.nih.gov/39251704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,42534588,Exploratory whole-exome analysis of low-density lipoprotein cholesterol and triglyceride response to Mediterranean-style dietary guidance: a focus on plasma lipoprotein pathways.,2026,10.3389/fnut.2026.1827989,https://pubmed.ncbi.nlm.nih.gov/42534588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,30475797,Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development.,2018,10.1371/journal.pgen.1007817,https://pubmed.ncbi.nlm.nih.gov/30475797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,35342690,Impact of 719Trp>Arg Polymorphism of KIF 6 Gene on Contrast Induced Nephropathy in Patients Undergoing Coronary Angiography or Percutaneous Coronary Intervention.,2022,10.5334/gh.1105,https://pubmed.ncbi.nlm.nih.gov/35342690/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,37172942,Nonsize Criteria for Surgical Intervention on the Ascending Thoracic Aorta.,2023,10.1055/s-0043-1766114,https://pubmed.ncbi.nlm.nih.gov/37172942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,34961832,Association between rs20456 and rs6930913 of Kinesin-Like Family 6 and Hypertension in a Chinese Cohort.,2021,10.1155/2021/1061800,https://pubmed.ncbi.nlm.nih.gov/34961832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,25283277,Kinesin family member 6 (kif6) is necessary for spine development in zebrafish.,2014,10.1002/dvdy.24208,https://pubmed.ncbi.nlm.nih.gov/25283277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,33119910,Identification of Functional Genetic Variants Associated With Alcohol Dependence and Related Phenotypes Using a High-Throughput Assay.,2020,10.1111/acer.14492,https://pubmed.ncbi.nlm.nih.gov/33119910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,33290818,Postembryonic screen for mutations affecting spine development in zebrafish.,2021,10.1016/j.ydbio.2020.11.009,https://pubmed.ncbi.nlm.nih.gov/33290818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,33731122,MassARRAY multigene screening combined with LDL-C and sdLDL-C detection for more favorable outcomes in type 2 diabetes mellitus therapy.,2021,10.1186/s12920-021-00937-8,https://pubmed.ncbi.nlm.nih.gov/33731122/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,29295555,"Relationship between Lipid Phenotypes, Overweight, Lipid Lowering Drug Response and KIF6 and HMG-CoA Genotypes in a Subset of the Brisighella Heart Study Population.",2017,10.3390/ijms19010049,https://pubmed.ncbi.nlm.nih.gov/29295555/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,29304815,"Association between KIF6 rs20455 polymorphism and the risk of coronary heart disease (CHD): a pooled analysis of 50 individual studies including 40,059 cases and 64,032 controls.",2018,10.1186/s12944-017-0651-y,https://pubmed.ncbi.nlm.nih.gov/29304815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,37877238,Pharmacogenomic variants affecting efficacy and toxicity of statins in a south Asian population from Sri Lanka.,2023,10.2217/pgs-2023-0149,https://pubmed.ncbi.nlm.nih.gov/37877238/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,30304062,KIF6 gene as a pharmacogenetic marker for lipid-lowering effect in statin treatment.,2018,10.1371/journal.pone.0205430,https://pubmed.ncbi.nlm.nih.gov/30304062/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,28097184,KIF6 719Arg Genetic Variant and Risk for Thoracic Aortic Dissection.,2016,10.12945/j.aorta.2016.16.003,https://pubmed.ncbi.nlm.nih.gov/28097184/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,26997531,Investigation of KIF6 Trp719Arg gene polymorphism in a case-control study of coronary artery disease and non-fatal myocardial infarction in the Eastern Province of Saudi Arabia.,2016,10.5144/0256-4947.2016.21.3.1140,https://pubmed.ncbi.nlm.nih.gov/26997531/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,23585310,Cost effectiveness of targeted high-dose atorvastatin therapy following genotype testing in patients with acute coronary syndrome.,2013,10.1007/s40273-013-0054-5,https://pubmed.ncbi.nlm.nih.gov/23585310/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,26236646,Genotyping and meta-analysis of KIF6 Trp719Arg polymorphism in South Indian Coronary Artery Disease patients: A case-control study.,2015,10.1016/j.mgene.2015.07.001,https://pubmed.ncbi.nlm.nih.gov/26236646/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,31436349,Pharmacogenetics of statins treatment: Efficacy and safety.,2019,10.1111/jcpt.13025,https://pubmed.ncbi.nlm.nih.gov/31436349/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,25562358,Statin pharmacogenomics: opportunities to improve patient outcomes and healthcare costs with genetic testing.,2012,10.3390/jpm2040158,https://pubmed.ncbi.nlm.nih.gov/25562358/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,23979174,Providing patients with pharmacogenetic test results affects adherence to statin therapy: results of the Additional KIF6 Risk Offers Better Adherence to Statins (AKROBATS) trial.,2014,10.1038/tpj.2013.27,https://pubmed.ncbi.nlm.nih.gov/23979174/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,22216121,A common KIF6 polymorphism increases vulnerability to low-density lipoprotein cholesterol: two meta-analyses and a meta-regression analysis.,2011,10.1371/journal.pone.0028834,https://pubmed.ncbi.nlm.nih.gov/22216121/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,23001387,Association of KIF6 variant with lipid level and angiographic coronary artery disease events risk in the Han Chinese population.,2012,10.3390/molecules170911269,https://pubmed.ncbi.nlm.nih.gov/23001387/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,22192511,"KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.",2012,10.1016/j.atherosclerosis.2011.11.037,https://pubmed.ncbi.nlm.nih.gov/22192511/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,21493817,Kinesin-like protein 6 (KIF6) polymorphism and the efficacy of rosuvastatin in primary prevention.,2011,10.1161/circgenetics.110.959353,https://pubmed.ncbi.nlm.nih.gov/21493817/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,21458191,"No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the heart protection study.",2011,10.1016/j.jacc.2011.02.015,https://pubmed.ncbi.nlm.nih.gov/21458191/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,21871624,Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and cardiovascular risk and efficacy of atorvastatin among subjects with diabetes on dialysis: the 4D study.,2011,10.1016/j.atherosclerosis.2011.07.126,https://pubmed.ncbi.nlm.nih.gov/21871624/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,24587901,The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women.,2014,10.1155/2014/328954,https://pubmed.ncbi.nlm.nih.gov/24587901/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,22914592,KIF6 719Arg allele is associated with statin effects on cholesterol levels in amnestic mild cognitive impairment and Alzheimer's disease patients.,2013,10.3233/jad-2012-121015,https://pubmed.ncbi.nlm.nih.gov/22914592/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,21435211,Survival bias and drug interaction can attenuate cross-sectional case-control comparisons of genes with health outcomes. An example of the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism and coronary heart disease.,2011,10.1186/1471-2350-12-42,https://pubmed.ncbi.nlm.nih.gov/21435211/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF6,ENSG00000164627,Unsafe,20886236,Genetic variants in the KIF6 region and coronary event reduction from statin therapy.,2011,10.1007/s00439-010-0892-6,https://pubmed.ncbi.nlm.nih.gov/20886236/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,41765929,Novel SLC16A2 mutations impair thyroid hormone transport and drive neurodevelopmental deficits in Chinese patients with allan-herndon-dudley syndrome.,2026,10.1038/s41598-026-40703-3,https://pubmed.ncbi.nlm.nih.gov/41765929/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,39829171,KIF9 Ameliorates Neuropathology and Cognitive Dysfunction by Promoting Macroautophagy in a Mouse Model of Alzheimer's Disease.,2025,10.1111/acel.14490,https://pubmed.ncbi.nlm.nih.gov/39829171/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,40975050,The kinesin motor Kif9 regulates centriolar satellite positioning during interphase.,2025,10.1016/j.cub.2025.08.064,https://pubmed.ncbi.nlm.nih.gov/40975050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,40538514,Mechanisms underlying hepatocellular carcinoma progression through N6-methyladenosine modifications of long non-coding RNA.,2025,10.3748/wjg.v31.i21.103184,https://pubmed.ncbi.nlm.nih.gov/40538514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,39735272,N6-methyladenosine-modified long non-coding RNA KIF9-AS1 promotes stemness and sorafenib resistance in hepatocellular carcinoma by upregulating SHOX2 expression.,2024,10.3748/wjg.v30.i48.5174,https://pubmed.ncbi.nlm.nih.gov/39735272/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,39158699,Distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility.,2024,10.1083/jcb.202312060,https://pubmed.ncbi.nlm.nih.gov/39158699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,40340968,Value of serum LncRNA KIF9-AS1 combined with CT signs in the diagnosis of benign and malignant early pulmonary nodules and its correlation with prognosis.,2025,10.1186/s13019-025-03438-2,https://pubmed.ncbi.nlm.nih.gov/40340968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,39446171,Distinct roles of two homologous kinesins in mammalian motile cilia.,2024,10.1083/jcb.202409214,https://pubmed.ncbi.nlm.nih.gov/39446171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,40879105,The Kinesin Motor Kif9 Disrupts Primary Cilia Length by Mispositioning Centriolar Satellites.,2025,10.1096/fj.202501115r,https://pubmed.ncbi.nlm.nih.gov/40879105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,36686457,Identification of bi-allelic KIF9 loss-of-function variants contributing to asthenospermia and male infertility in two Chinese families.,2022,10.3389/fendo.2022.1091107,https://pubmed.ncbi.nlm.nih.gov/36686457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,36276278,The lncRNA KIF9-AS1 Accelerates Hepatocellular Carcinoma Growth by Recruiting DNMT1 to Promote RAI2 DNA Methylation.,2022,10.1155/2022/3888798,https://pubmed.ncbi.nlm.nih.gov/36276278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,34526446,The motor domain of testis-enriched kinesin KIF9 is essential for its localization in the mouse flagellum.,2022,10.1538/expanim.21-0082,https://pubmed.ncbi.nlm.nih.gov/34526446/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,34750325,Long noncoding RNA KIF9-AS1 promotes cell apoptosis by targeting the microRNA-148a-3p/suppressor of cytokine signaling axis in inflammatory bowel disease.,2021,10.1097/meg.0000000000002309,https://pubmed.ncbi.nlm.nih.gov/34750325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,39251704,Two Tetrahymena kinesin-9 family members exhibit slow plus-end-directed motility in vitro.,2024,10.1038/s41598-024-71280-y,https://pubmed.ncbi.nlm.nih.gov/39251704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,32072696,Testis-enriched kinesin KIF9 is important for progressive motility in mouse spermatozoa.,2020,10.1096/fj.201902755r,https://pubmed.ncbi.nlm.nih.gov/32072696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,35531639,Kif9 is an active kinesin motor required for ciliary beating and proximodistal patterning of motile axonemes.,2023,10.1242/jcs.259535,https://pubmed.ncbi.nlm.nih.gov/35531639/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,32973955,KIF9-AS1 promotes nasopharyngeal carcinoma progression by suppressing miR-16.,2020,10.3892/ol.2020.12104,https://pubmed.ncbi.nlm.nih.gov/32973955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,35122963,"Coordination of two kinesin superfamily motor proteins, KIF3A and KIF13A, is essential for pericellular matrix degradation by membrane-type 1 matrix metalloproteinase (MT1-MMP) in cancer cells.",2022,10.1016/j.matbio.2022.01.004,https://pubmed.ncbi.nlm.nih.gov/35122963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,29207070,"KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease.",2018,10.3892/mmr.2017.8118,https://pubmed.ncbi.nlm.nih.gov/29207070/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,37004604,Up-regulated lncRNA SNHG9 mediates the pathogenesis of dilated cardiomyopathy via miR-326/EPHB3 axis.,2023,10.1007/s11239-023-02798-7,https://pubmed.ncbi.nlm.nih.gov/37004604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,32549918,Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes.,2020,10.1007/s13167-020-00209-y,https://pubmed.ncbi.nlm.nih.gov/32549918/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,32930942,What Happened in the Hippocampal Axon in a Rat Model of Posttraumatic Stress Disorder.,2022,10.1007/s10571-020-00960-w,https://pubmed.ncbi.nlm.nih.gov/32930942/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,32754889,Association of Maternal DNA Methylation and Offspring Birthweight.,2021,10.1007/s43032-020-00281-9,https://pubmed.ncbi.nlm.nih.gov/32754889/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,27346689,Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases.,2016,10.1016/j.ajhg.2016.05.003,https://pubmed.ncbi.nlm.nih.gov/27346689/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KIF9,ENSG00000088727,Unsafe,20886236,Genetic variants in the KIF6 region and coronary event reduction from statin therapy.,2011,10.1007/s00439-010-0892-6,https://pubmed.ncbi.nlm.nih.gov/20886236/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,41983751,Expressions of Kisspeptin System and Ki-67 in the Reproductive Tissues of Cyclic Bitches.,2026,10.1111/rda.70205,https://pubmed.ncbi.nlm.nih.gov/41983751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,41893538,Cadmium-Induced Neuroendocrine Alterations: Gene Expression of the Kisspeptin-GnRH Axis and Delayed Puberty in Male Rats.,2026,10.3390/toxics14030270,https://pubmed.ncbi.nlm.nih.gov/41893538/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42893863,Evidence that undernutrition increases AgRP signaling to arcuate kisspeptin neurons in male and female lambs.,2026,10.1262/jrd.2026-073,https://pubmed.ncbi.nlm.nih.gov/42893863/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42057695,Kisspeptin made in the preoptic area is required for normal estradiol-induced LH surges and optimal fertility in females.,2026,10.1210/endocr/bqag049,https://pubmed.ncbi.nlm.nih.gov/42057695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42188598,Effects of Zearalenone on the Kiss1/GPR54 System and Related Genes Expression in the Hypothalamus and Pituitary Gland of Weaned Gilts.,2026,10.3390/toxins18050195,https://pubmed.ncbi.nlm.nih.gov/42188598/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42038360,Spatial transcriptional mapping reveals the molecular characteristics of juxtaglomerular cell tumors.,2026,10.3389/fonc.2026.1768296,https://pubmed.ncbi.nlm.nih.gov/42038360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42100207,Vesicular GABA transport expression in kisspeptin cells may contribute to the preovulatory gonadotropin surge.,2026,10.3389/fendo.2026.1807596,https://pubmed.ncbi.nlm.nih.gov/42100207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,41430614,Kisspeptin mediates the impact of chronic psychological stress on reproductive and metabolic dysregulation in polycystic ovary syndrome: evidence from human and rat models.,2025,10.1186/s13048-025-01918-6,https://pubmed.ncbi.nlm.nih.gov/41430614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42385385,Progesterone-KISS1 axis impairs amniotic epithelial cell function and promotes premature rupture of membranes.,2026,10.1016/j.placenta.2026.06.016,https://pubmed.ncbi.nlm.nih.gov/42385385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42680947,Kisspeptin System: A Modulator of Neuroinflammation and Behaviour in Temporal Lobe Epileptic Rats.,2026,10.1007/s12035-026-06171-6,https://pubmed.ncbi.nlm.nih.gov/42680947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42123334,The KISS1/KISS1R Axis in Human Placentation: Molecular Mechanisms and Implications for Foetal Growth Restriction and Pre-Eclampsia.,2026,10.3390/ijms27093748,https://pubmed.ncbi.nlm.nih.gov/42123334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42794587,"Obesity, Oxidative Stress, and Inflammation in Precocious Puberty: Do All Roads Lead to the Hypothalamus?",2026,10.3390/ijms27188159,https://pubmed.ncbi.nlm.nih.gov/42794587/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,41611131,Kiss1-FASN participates fatty acid synthesis via high-fat diet in PgVAT of female mice.,2026,10.1016/j.jlr.2026.100986,https://pubmed.ncbi.nlm.nih.gov/41611131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42196560,The Effect of 2.45 GHz Radiofrequency Electromagnetic Radiation on Components of the Hypothalamic-Pituitary-Gonadal Axis in Male Rats.,2026,10.3390/ijms27104582,https://pubmed.ncbi.nlm.nih.gov/42196560/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42702882,Molecular characterization of circannual interval timing in the preoptic area and anteroventral periventricular nucleus in the Djungarian hamster (Phodopus sungorus).,2026,10.1111/jne.70258,https://pubmed.ncbi.nlm.nih.gov/42702882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42431255,"The endogenous ghrelin antagonist, LEAP2, accelerates puberty onset in conditions of early obesity.",2026,10.1016/j.metabol.2026.156695,https://pubmed.ncbi.nlm.nih.gov/42431255/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,41523580,Pancancer Analyses of KISS1 as a Potential Biomarker for Tumor Metastasis and Immunotherapy and Therapeutic Target for Breast Cancer.,2026,10.1155/ijog/5902518,https://pubmed.ncbi.nlm.nih.gov/41523580/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42287353,In-vitro effects of the urotensin-II peptide and its receptor antagonists on mcf-7 breast cancer cell line.,2026,10.1186/s43046-026-00366-7,https://pubmed.ncbi.nlm.nih.gov/42287353/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42913779,Alterations in Kiss1-Gnrh1 and Testicular Steroidogenic Gene Expression Following α-Terpineol Exposure in Male Rats.,2026,10.1016/j.fct.2026.116467,https://pubmed.ncbi.nlm.nih.gov/42913779/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42810967,Monosynaptic GABAergic projections from a subset of suprachiasmatic nucleus neuromedin S neurons suppress preoptic area kisspeptin neuron firing in female mice.,2026,10.1523/jneurosci.2277-25.2026,https://pubmed.ncbi.nlm.nih.gov/42810967/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42657207,Effect of High Intensity Sweeteners on the Reproductive System: From the Onset of Puberty to Menstrual Health: A Comprehensive Review of Human and Animal Evidence.,2026,10.2147/ijwh.s621813,https://pubmed.ncbi.nlm.nih.gov/42657207/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42873405,"Reassessing the Neoplasm Signal with Fezolinetant: Regulatory Inference, Mechanistic Plausibility, and the Case for Proactive Pharmacovigilance.",2026,10.1007/s40264-026-01737-8,https://pubmed.ncbi.nlm.nih.gov/42873405/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,41771825,GPR54 regulates non-small cell lung cancer development via dopa decarboxylase.,2026,10.1038/s41392-026-02591-x,https://pubmed.ncbi.nlm.nih.gov/41771825/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,41905662,"Effects of contraceptive (gestodene) on hatching, embryo development, and reproduction in Oryzias latipes.",2026,10.1016/j.etap.2026.105006,https://pubmed.ncbi.nlm.nih.gov/41905662/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,40524201,Hypothalamic kisspeptin alleviates myasthenia gravis by regulating Th1/Th17/Treg balance through Inhibition of NF-κB signaling pathway.,2025,10.1186/s12974-025-03486-4,https://pubmed.ncbi.nlm.nih.gov/40524201/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42229642,Anxiety-like behavior and social stress in adult zebrafish induced by 6PPD: Insights from single-cell RNA sequencing.,2026,10.1016/j.etap.2026.105057,https://pubmed.ncbi.nlm.nih.gov/42229642/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,42142733,Atrazine alters kisspeptin signaling and downstream neuroendocrine regulation following embryonic exposure in zebrafish.,2026,10.1016/j.tox.2026.154503,https://pubmed.ncbi.nlm.nih.gov/42142733/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,40541745,Maternal high-fat diet programs reproductive function of female offspring rat through IL-6-mediated regulation of Kiss1 gene methylation.,2025,10.1016/j.reprotox.2025.108975,https://pubmed.ncbi.nlm.nih.gov/40541745/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,38996103,Kisspeptin expression levels in patients with placenta previa: A randomized trial.,2024,10.1097/md.0000000000038866,https://pubmed.ncbi.nlm.nih.gov/38996103/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,41263402,Protective effects of gut originated Indolepropionic acid on testicular health through oxidative stress reduction and metabolic improvement in diabetic rats.,2025,10.1080/13813455.2025.2592024,https://pubmed.ncbi.nlm.nih.gov/41263402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,39880372,The Neuroendocrine Regulation of Reproductive Behavior and Emotional Control by Kisspeptin.,2025,10.1210/clinem/dgaf055,https://pubmed.ncbi.nlm.nih.gov/39880372/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,40564637,The Interplay Between Body Weight and the Onset of Puberty.,2025,10.3390/children12060679,https://pubmed.ncbi.nlm.nih.gov/40564637/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,40430029,Kisspeptin Receptor Agonists and Antagonists: Strategies for Discovery and Implications for Human Health and Disease.,2025,10.3390/ijms26104890,https://pubmed.ncbi.nlm.nih.gov/40430029/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,40320066,Prenatal genistein exposure in rats affects pubertal onset and serum reproductive hormone levels in male offsprings via the hypothalamic-pituitary-gonadal axis.,2025,10.1016/j.fct.2025.115498,https://pubmed.ncbi.nlm.nih.gov/40320066/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,15020672,"Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts.",2004,10.1242/jcs.00971,https://pubmed.ncbi.nlm.nih.gov/15020672/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,12574233,Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans.,2003,10.1210/jc.2002-021235,https://pubmed.ncbi.nlm.nih.gov/12574233/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,12414911,Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells.,2002,10.1210/jc.2002-021093,https://pubmed.ncbi.nlm.nih.gov/12414911/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,11457843,"The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.",2001,10.1074/jbc.m104847200,https://pubmed.ncbi.nlm.nih.gov/11457843/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,11385580,Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.,2001,10.1038/35079135,https://pubmed.ncbi.nlm.nih.gov/11385580/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KISS1,ENSG00000170498,Unsafe,8944003,"KiSS-1, a novel human malignant melanoma metastasis-suppressor gene.",1996,10.1093/jnci/88.23.1731,https://pubmed.ncbi.nlm.nih.gov/8944003/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,42824381,Anti-KLHL11 antibody encephalitis without detectable malignancy: a case report and literature review.,2026,10.3389/fimmu.2026.1913121,https://pubmed.ncbi.nlm.nih.gov/42824381/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,42305527,Clinical heterogeneity and treatment optimization in anti-KLHL11 encephalitis: two case reports and literature review.,2026,10.3389/fimmu.2026.1729540,https://pubmed.ncbi.nlm.nih.gov/42305527/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,41280942,Case Report: KLHL11 encephalitis in a female patient with dual primary malignancies of breast and lung cancer: response to FcRn inhibitor therapy.,2025,10.3389/fimmu.2025.1613070,https://pubmed.ncbi.nlm.nih.gov/41280942/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,41941689,Vestibular and Ocular Motor Phenotype in a Case of Paraneoplastic Autoimmune Kelch-Like Protein-11 Encephalitis.,2026,10.1212/nxi.0000000000200576,https://pubmed.ncbi.nlm.nih.gov/41941689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,42317309,Immune checkpoint inhibitor-related kelch-like protein 11-IgG cerebellitis successfully treated with efgartigimod as rescue therapy: a case report.,2026,10.3389/fimmu.2026.1864182,https://pubmed.ncbi.nlm.nih.gov/42317309/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,42154290,Nationwide screening identifies an expanded clinical spectrum of anti-KLHL11 antibody-associated neurologic disease in Japan.,2026,10.1007/s00415-026-13816-y,https://pubmed.ncbi.nlm.nih.gov/42154290/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,42214057,"Clinical Manifestations, Tumor Associations, and Long-Term Outcomes of Anti-KLHL11 Encephalitis.",2026,10.1212/nxi.0000000000200597,https://pubmed.ncbi.nlm.nih.gov/42214057/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,42039192,"Case Report: Atypical anti-KLHL11 antibody encephalitis: recurrent staring spells, serial negative MRI findings, and a tripartite diagnostic journey.",2026,10.3389/fimmu.2026.1808939,https://pubmed.ncbi.nlm.nih.gov/42039192/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,40676604,Anti-kelch-like protein 11 antibody-associated encephalitis: two case reports and literature review.,2025,10.1186/s12883-025-04308-z,https://pubmed.ncbi.nlm.nih.gov/40676604/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,41624872,Autoimmune encephalitis associated with antibodies against intracellular antigens in children.,2025,10.3389/fimmu.2025.1678497,https://pubmed.ncbi.nlm.nih.gov/41624872/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,39978939,"Paraneoplastic KLHL11 encephalitis presenting with progressive tinnitus, hearing loss and ataxia.",2025,10.1136/pn-2024-004498,https://pubmed.ncbi.nlm.nih.gov/39978939/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,39575244,"Case report: The case report of ofatumumab, a fully human anti-CD20 monoclonal antibody, in the treatment of KLHL11 encephalitis.",2024,10.3389/fimmu.2024.1456840,https://pubmed.ncbi.nlm.nih.gov/39575244/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,40583956,Pediatric case of Kelch-like protein 11 (KLHL11) encephalitis with long-term follow-up: pitfalls in diagnosis of pediatric autoimmune encephalitis.,2025,10.29399/npa.28870,https://pubmed.ncbi.nlm.nih.gov/40583956/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,40936049,Anti-Kelch-like protein 11 antibody encephalitis presenting with progressive cognitive deficits in an older woman: a case report and literature review.,2025,10.1007/s10072-025-08450-x,https://pubmed.ncbi.nlm.nih.gov/40936049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,38148071,Kelch-like Protein 11 (KLHL11) Antibodies in Children With Seizures of Undetermined Cause.,2024,10.21873/invivo.13445,https://pubmed.ncbi.nlm.nih.gov/38148071/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,37982047,Kelch-like Protein-11 Encephalitis Associated With Squamous Cell Carcinoma of Unknown Origin: A Case Report.,2024,10.1212/cpj.0000000000200219,https://pubmed.ncbi.nlm.nih.gov/37982047/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,38484218,Immune Checkpoint Inhibitor-Associated Kelch-Like Protein-11 IgG Brainstem Encephalitis.,2024,10.1212/nxi.0000000000200218,https://pubmed.ncbi.nlm.nih.gov/38484218/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,37954647,Anti-Kelch-like protein 11 antibody encephalitis: a case report and literature review.,2023,10.3389/fneur.2023.1273051,https://pubmed.ncbi.nlm.nih.gov/37954647/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,39735552,"Frequency, characteristics, and immunological accompaniments of ataxia in anti-NMDAR antibody-associated encephalitis.",2024,10.3389/fimmu.2024.1500904,https://pubmed.ncbi.nlm.nih.gov/39735552/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,41349468,"Integrated m6A reader network in acute myeloid leukemia: prognostic modeling, immune modulation, and functional validation of YTHDF3.",2026,10.1016/j.intimp.2025.115976,https://pubmed.ncbi.nlm.nih.gov/41349468/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,42289339,[A case of anti-Kelch-like protein 11 (KLHL11) antibody-positive opsoclonus-myoclonus syndrome associated with small cell lung cancer that improved after immunotherapy and cancer treatment].,2026,10.5692/clinicalneurol.cn-002240,https://pubmed.ncbi.nlm.nih.gov/42289339/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,38772930,Clinical and serological insights into paraneoplastic brachial amyotrophic diplegia.,2024,10.1007/s00415-024-12425-x,https://pubmed.ncbi.nlm.nih.gov/38772930/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL11,ENSG00000178502,Unsafe,34561925,Long-term MRI changes in a patient with Kelch-like protein 11-associated paraneoplastic neurological syndrome.,2021,10.1111/ene.15120,https://pubmed.ncbi.nlm.nih.gov/34561925/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL35,ENSG00000149243,Unsafe,41114922,Comprehensive analysis of KLHL35 expression and its prognostic value in cancer: implications for colorectal cancer diagnosis and therapy.,2025,10.1007/s12672-025-03715-5,https://pubmed.ncbi.nlm.nih.gov/41114922/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL35,ENSG00000149243,Unsafe,42724399,Non-small cell lung cancer and tumor-educated platelets: screening of biomarkers and construction of a prognostic model.,2026,10.21037/tcr-2026-1075,https://pubmed.ncbi.nlm.nih.gov/42724399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL35,ENSG00000149243,Unsafe,35928453,Multi-Omics Analysis of the Tumor Microenvironment in Liver Metastasis of Colorectal Cancer Identified FJX1 as a Novel Biomarker.,2022,10.3389/fgene.2022.960954,https://pubmed.ncbi.nlm.nih.gov/35928453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL35,ENSG00000149243,Unsafe,39920741,Unveiling prognostic value of JAK/STAT signaling pathway related genes in colorectal cancer: a study of Mendelian randomization analysis.,2025,10.1186/s13027-025-00640-8,https://pubmed.ncbi.nlm.nih.gov/39920741/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL35,ENSG00000149243,Unsafe,38478169,"Analysis and experimental validation of necroptosis-related molecular classification, immune signature and feature genes in Alzheimer's disease.",2024,10.1007/s10495-024-01943-8,https://pubmed.ncbi.nlm.nih.gov/38478169/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL35,ENSG00000149243,Unsafe,39449361,Examining the Utility of the Mammalian Methylation Array for Pan-Mammalian Analysis of Monozygotic Twinning.,2024,10.3390/epigenomes8040037,https://pubmed.ncbi.nlm.nih.gov/39449361/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL35,ENSG00000149243,Unsafe,36685979,Developing a pyroptosis-related gene signature to better predict the prognosis and immune status of patients with head and neck squamous cell carcinoma.,2022,10.3389/fgene.2022.988606,https://pubmed.ncbi.nlm.nih.gov/36685979/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL35,ENSG00000149243,Unsafe,37158531,Construction of a Risk Model for Colon Cancer Prognosis Based on Ubiquitin-Related Genes.,2023,10.5152/tjg.2023.22465,https://pubmed.ncbi.nlm.nih.gov/37158531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL35,ENSG00000149243,Unsafe,35500859,Gaseous air pollutants and DNA methylation in a methylome-wide association study of an ethnically and environmentally diverse population of U.S. adults.,2022,10.1016/j.envres.2022.113360,https://pubmed.ncbi.nlm.nih.gov/35500859/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL35,ENSG00000149243,Unsafe,36335815,scBPGRN: Integrating single-cell multi-omics data to construct gene regulatory networks based on BP neural network.,2022,10.1016/j.compbiomed.2022.106249,https://pubmed.ncbi.nlm.nih.gov/36335815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL35,ENSG00000149243,Unsafe,35116695,A special prognostic indicator: tumor mutation burden combined with immune infiltrates in lung adenocarcinoma with TP53 mutation.,2021,10.21037/tcr-21-565,https://pubmed.ncbi.nlm.nih.gov/35116695/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL35,ENSG00000149243,Unsafe,31189705,"Tissue-Specific Gene Expression during Productive Human Papillomavirus 16 Infection of Cervical, Foreskin, and Tonsil Epithelium.",2019,10.1128/jvi.00915-19,https://pubmed.ncbi.nlm.nih.gov/31189705/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL35,ENSG00000149243,Unsafe,22457049,Genome-wide analysis of DNA methylation identifies novel cancer-related genes in hepatocellular carcinoma.,2012,10.1007/s13277-012-0378-3,https://pubmed.ncbi.nlm.nih.gov/22457049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL35,ENSG00000149243,Unsafe,21132003,Genome-wide methylation analysis identifies epigenetically inactivated candidate tumour suppressor genes in renal cell carcinoma.,2011,10.1038/onc.2010.525,https://pubmed.ncbi.nlm.nih.gov/21132003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL35,ENSG00000149243,Unsafe,25993294,The potential role of DNA methylation in abdominal aortic aneurysms.,2015,10.3390/ijms160511259,https://pubmed.ncbi.nlm.nih.gov/25993294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL35,ENSG00000149243,Unsafe,27383059,Maternal Age at Delivery Is Associated with an Epigenetic Signature in Both Newborns and Adults.,2016,10.1371/journal.pone.0156361,https://pubmed.ncbi.nlm.nih.gov/27383059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,42432252,UbiDash: A UPS proteomic atlas for tissue-aware degrader design.,2026,10.1038/s41418-026-01791-w,https://pubmed.ncbi.nlm.nih.gov/42432252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,41796324,Genetic subtraction reveals divergent pathways and targets in anxiety-related and anxiety-independent TMD.,2026,10.1186/s10194-026-02304-3,https://pubmed.ncbi.nlm.nih.gov/41796324/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,40353626,KLHL7 enhances cell viability and cell cycle progression in glioma via glutamine metabolism by activating the β-catenin signaling pathway.,2025,10.4149/neo_2025_241227n539,https://pubmed.ncbi.nlm.nih.gov/40353626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,39865021,[Effects of long non-coding RNA KLHL7-AS1 on the proliferation and apoptosis of nucleus pulposus cells under the environment of oxidative stress and its mechanism].,2025,10.3760/cma.j.cn112137-20240821-01922,https://pubmed.ncbi.nlm.nih.gov/39865021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,37378318,KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2.,2023,10.1016/j.isci.2023.106914,https://pubmed.ncbi.nlm.nih.gov/37378318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,37817908,Testing for Allele-specific Expression from Human Brain Samples.,2023,10.21769/bioprotoc.4832,https://pubmed.ncbi.nlm.nih.gov/37817908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,38333279,PERCHING syndrome caused by variant gene KLHL7 in the first Iranian patient: a case report study.,2024,10.1097/ms9.0000000000001429,https://pubmed.ncbi.nlm.nih.gov/38333279/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,36471356,Bioinformatics analysis identifies potential hub genes and crucial pathways in the pathogenesis of asthenozoospermia.,2022,10.1186/s12920-022-01407-5,https://pubmed.ncbi.nlm.nih.gov/36471356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,35699517,Clinical and molecular genetic findings of Crisponi/cold-induced sweating syndrome (CS/CISS) spectrum in patients from Turkey.,2022,10.1111/cge.14177,https://pubmed.ncbi.nlm.nih.gov/35699517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,39451534,Whole-Exome Sequencing Improves Understanding of Inherited Retinal Dystrophies in Korean Patients.,2024,10.3390/cimb46100654,https://pubmed.ncbi.nlm.nih.gov/39451534/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,39773736,Gastric Adenocarcinoma with Enteroblastic Differentiation.,2025,10.1159/000543330,https://pubmed.ncbi.nlm.nih.gov/39773736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,34212217,Regular football training down-regulates miR-1303 muscle expression in veterans.,2021,10.1007/s00421-021-04733-1,https://pubmed.ncbi.nlm.nih.gov/34212217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,32466770,CICERO: a versatile method for detecting complex and diverse driver fusions using cancer RNA sequencing data.,2020,10.1186/s13059-020-02043-x,https://pubmed.ncbi.nlm.nih.gov/32466770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,30142437,Bi-allelic c.181_183delTGT in BTB domain of KLHL7 is associated with overlapping phenotypes of Crisponi/CISS1-like and Bohring-Opitz like syndrome.,2019,10.1016/j.ejmg.2018.08.009,https://pubmed.ncbi.nlm.nih.gov/30142437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,31953236,A novel PTC mutation in the BTB domain of KLHL7 gene in two patients with Bohring-Opitz syndrome-like features.,2020,10.1016/j.ejmg.2020.103849,https://pubmed.ncbi.nlm.nih.gov/31953236/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,37076692,High diagnostic potential of short and long read genome sequencing with transcriptome analysis in exome-negative developmental disorders.,2023,10.1007/s00439-023-02553-1,https://pubmed.ncbi.nlm.nih.gov/37076692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,32590884,"Congenital mesoblastic nephroma is characterised by kinase mutations including EGFR internal tandem duplications, the ETV6-NTRK3 fusion, and the rare KLHL7-BRAF fusion.",2020,10.1111/his.14194,https://pubmed.ncbi.nlm.nih.gov/32590884/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,28391543,Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson's disease on chromosome 7p15.3.,2017,10.1007/s10048-017-0514-8,https://pubmed.ncbi.nlm.nih.gov/28391543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,29633055,Clinical and biological roles of Kelch-like family member 7 in breast cancer: a marker of poor prognosis.,2018,10.1007/s10549-018-4777-z,https://pubmed.ncbi.nlm.nih.gov/29633055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,35606755,Construction and validation of immune-related LncRNAs classifier to predict prognosis and immunotherapy response in laryngeal squamous cell carcinoma.,2022,10.1186/s12957-022-02608-z,https://pubmed.ncbi.nlm.nih.gov/35606755/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,27392078,Bi-allelic Mutations in KLHL7 Cause a Crisponi/CISS1-like Phenotype Associated with Early-Onset Retinitis Pigmentosa.,2016,10.1016/j.ajhg.2016.05.026,https://pubmed.ncbi.nlm.nih.gov/27392078/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,21828050,Ubiquitin ligase activity of Cul3-KLHL7 protein is attenuated by autosomal dominant retinitis pigmentosa causative mutation.,2011,10.1074/jbc.m111.245126,https://pubmed.ncbi.nlm.nih.gov/21828050/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,19520207,"Mutations in a BTB-Kelch protein, KLHL7, cause autosomal-dominant retinitis pigmentosa.",2009,10.1016/j.ajhg.2009.05.007,https://pubmed.ncbi.nlm.nih.gov/19520207/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,20547956,Phenotype associated with mutation in the recently identified autosomal dominant retinitis pigmentosa KLHL7 gene.,2010,10.1001/archophthalmol.2010.98,https://pubmed.ncbi.nlm.nih.gov/20547956/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLHL7,ENSG00000122550,Unsafe,16918702,Detection of autoantibodies to the BTB-kelch protein KLHL7 in cancer sera.,2006,10.1111/j.1365-3083.2006.01821.x,https://pubmed.ncbi.nlm.nih.gov/16918702/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,40949095,KLK15 alters connective tissues in hypermobile Ehlers-Danlos syndrome.,2025,10.1016/j.isci.2025.113343,https://pubmed.ncbi.nlm.nih.gov/40949095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,41865695,Evaluation of a gene expression panel for prognostic stratification in high-risk prostate cancer.,2026,10.1016/j.ctarc.2026.101164,https://pubmed.ncbi.nlm.nih.gov/41865695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,39413985,Identifying prognostic hub genes and key pathways in pediatric adrenocortical tumors through RNA sequencing and Co-expression analysis.,2024,10.1016/j.mce.2024.112383,https://pubmed.ncbi.nlm.nih.gov/39413985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,29958881,Expression profile of human tissue kallikrein 15 provides preliminary insights into its roles in the prostate and testis.,2018,10.1016/j.clinbiochem.2018.06.017,https://pubmed.ncbi.nlm.nih.gov/29958881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,32334022,"Identification of six novel alternative transcripts of the human kallikrein-related peptidase 15 (KLK15), using 3'RACE and high-throughput sequencing.",2020,10.1016/j.gene.2020.144708,https://pubmed.ncbi.nlm.nih.gov/32334022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,37139608,Prognostic impact of kallikrein-related peptidase transcript levels in prostate cancer.,2023,10.1002/ijc.34551,https://pubmed.ncbi.nlm.nih.gov/37139608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,31515705,Kallikrein-Related Peptidase mRNA Expression in Adenoid Cystic Carcinoma of Salivary Glands: A Polymerase Chain Reaction Study.,2020,10.1007/s12105-019-01076-4,https://pubmed.ncbi.nlm.nih.gov/31515705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,29095848,"Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer.",2017,10.1371/journal.pone.0186847,https://pubmed.ncbi.nlm.nih.gov/29095848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,29928903,Biochemical characterization of human tissue kallikrein 15 and examination of its potential role in cancer.,2018,10.1016/j.clinbiochem.2018.06.007,https://pubmed.ncbi.nlm.nih.gov/29928903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,32592124,Human Tissue Kallikreins in Polymorphous Adenocarcinoma: A Polymerase Chain Reaction and Immunohistochemical Study.,2021,10.1007/s12105-020-01196-2,https://pubmed.ncbi.nlm.nih.gov/32592124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,32366393,Gene Expression of Kallikreins in Breast Cancer Cell Lines.,2020,10.21873/anticanres.14219,https://pubmed.ncbi.nlm.nih.gov/32366393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,23620432,Quantified KLK15 gene expression levels discriminate prostate cancer from benign tumors and constitute a novel independent predictor of disease progression.,2013,10.1002/pros.22667,https://pubmed.ncbi.nlm.nih.gov/23620432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,20067463,Expression analysis and study of the KLK15 mRNA splice variants in prostate cancer and benign prostatic hyperplasia.,2010,10.1111/j.1349-7006.2009.01450.x,https://pubmed.ncbi.nlm.nih.gov/20067463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,29707153,Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types.,2018,10.18632/oncotarget.24947,https://pubmed.ncbi.nlm.nih.gov/29707153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,26224476,Prognostic significance of human tissue kallikrein-related peptidases 11 and 15 in gastric cancer.,2016,10.1007/s13277-015-3802-7,https://pubmed.ncbi.nlm.nih.gov/26224476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,31904348,Kallikrein-related peptidases protein expression in lymphoid tissues suggests potential implications in immune response.,2020,10.1016/j.clinbiochem.2019.12.015,https://pubmed.ncbi.nlm.nih.gov/31904348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,21457553,A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival.,2011,10.1186/1471-2407-11-119,https://pubmed.ncbi.nlm.nih.gov/21457553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,20473923,KLK15 is a prognostic marker for progression-free survival in patients with radical prostatectomy.,2010,10.1002/ijc.25435,https://pubmed.ncbi.nlm.nih.gov/20473923/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,23391636,Association of transcript levels of 10 established or candidate-biomarker gene targets with cancerous versus non-cancerous prostate tissue from radical prostatectomy specimens.,2013,10.1016/j.clinbiochem.2013.01.019,https://pubmed.ncbi.nlm.nih.gov/23391636/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,22132073,Association between Prostinogen (KLK15) genetic variants and prostate cancer risk and aggressiveness in Australia and a meta-analysis of GWAS data.,2011,10.1371/journal.pone.0026527,https://pubmed.ncbi.nlm.nih.gov/22132073/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,25833159,Tamoxifen prevents apoptosis and follicle loss from cyclophosphamide in cultured rat ovaries.,2015,10.1095/biolreprod.114.126136,https://pubmed.ncbi.nlm.nih.gov/25833159/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,19823874,A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33.,2010,10.1007/s00439-009-0751-5,https://pubmed.ncbi.nlm.nih.gov/19823874/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KLK15,ENSG00000174562,Unsafe,11010966,Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer.,2001,10.1074/jbc.m005432200,https://pubmed.ncbi.nlm.nih.gov/11010966/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,41930176,KNL1 Regulates Ferroptosis Resistance and Migration in Lung Adenocarcinoma Cells via AMPK-mTOR Signaling.,2026,10.32604/or.2026.075191,https://pubmed.ncbi.nlm.nih.gov/41930176/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,42384462,Phillyrin protects against myocardial ischemia/reperfusion injury by promoting KNL1 K605 acetylation to inhibit the p53/p21 pathway.,2026,10.3724/abbs.2026104,https://pubmed.ncbi.nlm.nih.gov/42384462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,42338338,MIS12 Is Required for Kinetochore-Microtubule Attachment in Oocyte Meiosis.,2026,10.1002/advs.76171,https://pubmed.ncbi.nlm.nih.gov/42338338/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,42058159,Proteomics reveals extensive phosphoregulation of outer kinetochore protein KNL1.,2026,10.17912/micropub.biology.002102,https://pubmed.ncbi.nlm.nih.gov/42058159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,37928953,Role of Kinetochore Scaffold 1 (KNL1) in Tumorigenesis and Tumor Immune Microenvironment in Pan-Cancer: Bioinformatics Analyses and Validation of Expression.,2023,10.2147/ijgm.s424245,https://pubmed.ncbi.nlm.nih.gov/37928953/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,42338480,"hSpindly dynamics modulate spindle assembly checkpoint signaling, promoting resistance to mitotic inhibitors.",2026,10.1016/j.isci.2026.116312,https://pubmed.ncbi.nlm.nih.gov/42338480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,36904774,The Loss-Function of KNL1 Causes Oligospermia and Asthenospermia in Mice by Affecting the Assembly and Separation of the Spindle through Flow Cytometry and Immunofluorescence.,2023,10.3390/s23052571,https://pubmed.ncbi.nlm.nih.gov/36904774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,39908360,Arabidopsis KNL1 recruits type one protein phosphatase to kinetochores to silence the spindle assembly checkpoint.,2025,10.1126/sciadv.adq4033,https://pubmed.ncbi.nlm.nih.gov/39908360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,40641039,High-throughput screening identifies a previously undescribed checkpoint controlling mitotic progression in response to DNA damage.,2025,10.1111/febs.70183,https://pubmed.ncbi.nlm.nih.gov/40641039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,37661832,A systematic approach identifies p53-DREAM pathway target genes associated with blood or brain abnormalities.,2023,10.1242/dmm.050376,https://pubmed.ncbi.nlm.nih.gov/37661832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,36776306,KNL1 is a prognostic and diagnostic biomarker related to immune infiltration in patients with uterine corpus endometrial carcinoma.,2023,10.3389/fonc.2023.1090779,https://pubmed.ncbi.nlm.nih.gov/36776306/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,38170753,A coadapted KNL1 and spindle assembly checkpoint axis orchestrates precise mitosis in Arabidopsis.,2024,10.1073/pnas.2316583121,https://pubmed.ncbi.nlm.nih.gov/38170753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,38583438,Kinetochore scaffold 1 downregulation suppressed the development of non-small cell lung cancer by inactivating the phosphatidylinositol 3 kinase/protein kinase B (AKT)/nuclear factor-kappa B pathway.,2024,10.26402/jpp.2024.1.05,https://pubmed.ncbi.nlm.nih.gov/38583438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,35034926,CASC5 is a potential cancer-testis gene in human urinary bladder transitional cell carcinoma.,2021,10.5582/ddt.2021.01108,https://pubmed.ncbi.nlm.nih.gov/35034926/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,37009050,A novel long noncoding RNA AC125257.1 facilitates colorectal cancer progression by targeting miR-133a-3p/CASC5 axis.,2023,10.1515/med-2023-0631,https://pubmed.ncbi.nlm.nih.gov/37009050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,41774747,Integrating sequence-based GWAS and comparative genomic analysis reveals conservation and species-specificity of putative functional variants influencing tail length and tail abnormalities in pigs and sheep.,2026,10.1371/journal.pone.0343836,https://pubmed.ncbi.nlm.nih.gov/41774747/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,33566033,[CASC5 Gene Expression Changes Correlate with Targeted Mutations in Leukemia].,2021,10.31857/s002689842101002x,https://pubmed.ncbi.nlm.nih.gov/33566033/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,36685823,High expression of KNL1 in prostate adenocarcinoma is associated with poor prognosis and immune infiltration.,2022,10.3389/fgene.2022.1100787,https://pubmed.ncbi.nlm.nih.gov/36685823/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,38857680,Kaempferol from Alpinia officinarum hance induces G2/M cell cycle arrest in hepatocellular carcinoma cells by regulating the ATM/CHEK2/KNL1 pathway.,2024,10.1016/j.jep.2024.118430,https://pubmed.ncbi.nlm.nih.gov/38857680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,28901661,D40/KNL1/CASC5 and autosomal recessive primary microcephaly.,2017,10.1111/cga.12252,https://pubmed.ncbi.nlm.nih.gov/28901661/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,39687194,Interspecies transcriptome profiles of human T cell activation and liver inflammation in a xenogeneic graft-versus-host disease model.,2024,10.1016/j.heliyon.2024.e40559,https://pubmed.ncbi.nlm.nih.gov/39687194/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,37712330,A bifunctional kinase-phosphatase module balances mitotic checkpoint strength and kinetochore-microtubule attachment stability.,2023,10.15252/embj.2022112630,https://pubmed.ncbi.nlm.nih.gov/37712330/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,38447274,Differential anti-viral response to respiratory syncytial virus A in preterm and term infants.,2024,10.1016/j.ebiom.2024.105044,https://pubmed.ncbi.nlm.nih.gov/38447274/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,39604214,Fibrous corona is reduced in cancer cell lines that attenuate microtubule nucleation from kinetochores.,2025,10.1111/cas.16406,https://pubmed.ncbi.nlm.nih.gov/39604214/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,34663805,Inhibiting microcephaly genes as alternative to microtubule targeting agents to treat brain tumors.,2021,10.1038/s41419-021-04259-6,https://pubmed.ncbi.nlm.nih.gov/34663805/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,36819578,Expression analysis of human glioma susceptibility gene and P53 in human glioma and its clinical significance based on bioinformatics.,2023,10.21037/atm-22-5646,https://pubmed.ncbi.nlm.nih.gov/36819578/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,31315522,Effect of KNL1 on the proliferation and apoptosis of colorectal cancer cells.,2019,10.1177/1533033819858668,https://pubmed.ncbi.nlm.nih.gov/31315522/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,34245124,Genomic analyses of high-grade neuroendocrine gynecological malignancies reveal a unique mutational landscape and therapeutic vulnerabilities.,2021,10.1002/1878-0261.13057,https://pubmed.ncbi.nlm.nih.gov/34245124/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,31649151,Delineating the contribution of Spc105-bound PP1 to spindle checkpoint silencing and kinetochore microtubule attachment regulation.,2019,10.1083/jcb.201810172,https://pubmed.ncbi.nlm.nih.gov/31649151/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,30390708,"Dysregulation of NCAPG, KNL1, miR-148a-3p, miR-193b-3p, and miR-1179 may contribute to the progression of gastric cancer.",2018,10.1186/s40659-018-0192-5,https://pubmed.ncbi.nlm.nih.gov/30390708/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,34944699,Regulation of Oncogenic Targets by Tumor-Suppressive miR-150-3p in Lung Squamous Cell Carcinoma.,2021,10.3390/biomedicines9121883,https://pubmed.ncbi.nlm.nih.gov/34944699/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,33125045,Kinetochore phosphatases suppress autonomous Polo-like kinase 1 activity to control the mitotic checkpoint.,2020,10.1083/jcb.202002020,https://pubmed.ncbi.nlm.nih.gov/33125045/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,33397691,The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.,2021,10.1128/mcb.00333-20,https://pubmed.ncbi.nlm.nih.gov/33397691/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,12618768,Characterization of the MLL partner gene AF15q14 involved in t(11;15)(q23;q14).,2003,10.1038/sj.onc.1206272,https://pubmed.ncbi.nlm.nih.gov/12618768/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,12087463,Frequent expression of new cancer/testis gene D40/AF15q14 in lung cancers of smokers.,2002,10.1038/sj.bjc.6600328,https://pubmed.ncbi.nlm.nih.gov/12087463/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KNL1,ENSG00000137812,Unsafe,10980622,"AF15q14, a novel partner gene fused to the MLL gene in an acute myeloid leukaemia with a t(11;15)(q23;q14).",2000,10.1038/sj.onc.1203789,https://pubmed.ncbi.nlm.nih.gov/10980622/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,42758764,Integrated analysis of bulk transcriptomics and single-cell transcriptomics revealed the association characteristics between heart failure and β-hydroxybutyrylation-related genes.,2026,10.1371/journal.pone.0357103,https://pubmed.ncbi.nlm.nih.gov/42758764/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,42725791,Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9.,2026,10.1002/advs.77724,https://pubmed.ncbi.nlm.nih.gov/42725791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,42331750,KPNA2 Drives Immunosuppression in Ovarian Cancer via CCL2/CCR2-Dependent MDSC Recruitment.,2026,10.1111/cas.70440,https://pubmed.ncbi.nlm.nih.gov/42331750/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,42006340,PTGS2 and KPNA2 as key mediators of DEHP-induced osteoarthritis: From network prediction to machine learning and dynamic simulation validation.,2026,10.1016/j.isci.2026.115388,https://pubmed.ncbi.nlm.nih.gov/42006340/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,42456537,Identification and functional validation of a four-gene signature associated with radiotherapy resistance in oral squamous cell carcinoma.,2026,10.1016/j.tranon.2026.102918,https://pubmed.ncbi.nlm.nih.gov/42456537/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,42848851,KPNA2-Mediated MYC Nuclear Import Enhances CAR-T Cell Memory and Potentiates Antitumor Efficacy.,2026,10.1182/blood.2026034296,https://pubmed.ncbi.nlm.nih.gov/42848851/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,42469441,High KPNA2 expression predicts poor prognosis in pathological T4 colorectal cancer by importing c-Myc into the nucleus to suppress p53-dependent p21 expression.,2026,10.1038/s41416-026-03552-5,https://pubmed.ncbi.nlm.nih.gov/42469441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,42406150,"KPNA2 knockdown suppresses gastric cancer progression through modulation of the β-catenin/EMT signaling axis, inducing cell cycle arrest, apoptosis, and reduced metastatic capacity.",2026,10.1007/s10735-026-10887-z,https://pubmed.ncbi.nlm.nih.gov/42406150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,42310155,NCBP1 promotes the malignant progression of Wilms' tumor through stabilization of KPNA2 mRNA.,2026,10.1038/s41417-026-01050-7,https://pubmed.ncbi.nlm.nih.gov/42310155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,39423201,Normal male fertility in a mouse model of KPNA2 deficiency.,2024,10.1371/journal.pone.0304189,https://pubmed.ncbi.nlm.nih.gov/39423201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,42629199,Activation of the KPNA2-mediated nuclear import of PPARα by KIF13B mitigates alcohol-associated liver steatosis.,2026,10.1136/gutjnl-2026-339656,https://pubmed.ncbi.nlm.nih.gov/42629199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,40785975,KPNA2 promotes lung adenocarcinoma progression by inducing glycolysis-assisted MYC nuclear translocation.,2025,10.1007/s10616-025-00808-5,https://pubmed.ncbi.nlm.nih.gov/40785975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,41413918,A positive feedback loop between KPNA2 and FOXM1 promotes the proliferation of lung adenocarcinoma.,2025,10.1186/s40001-025-03674-1,https://pubmed.ncbi.nlm.nih.gov/41413918/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,42737438,Integrated Transcriptomic Analyses Identify Four Prognosis-Associated Genes in Hepatocellular Carcinoma.,2026,10.3390/ijms27177535,https://pubmed.ncbi.nlm.nih.gov/42737438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,41627517,Dynamic Transcriptomic Profiling of the HPG Axis Reveals Stage-Specific Regulatory Networks Underlying Natural Sex Change in Orange-Spotted Grouper (Epinephelus coioides).,2026,10.1007/s10126-026-10576-8,https://pubmed.ncbi.nlm.nih.gov/41627517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,40830974,"Coordinating oncogenesis and immune evasion: KPNA2, GOLM1, and TK1 as novel CAR T-cell targets in lung adenocarcinoma.",2025,10.1186/s40001-025-02955-z,https://pubmed.ncbi.nlm.nih.gov/40830974/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,40830912,MiR-20a-5p Inhibits Bladder Cancer Proliferation and Migration by Targeting KPNA2.,2025,10.1111/jcmm.70785,https://pubmed.ncbi.nlm.nih.gov/40830912/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,41120255,The deubiquitination enzyme USP14 promotes the tumourigenesis of gastric cancer by enhancing c-MYC nuclear translocation through deubiquitination of KPNA2.,2025,10.1038/s41419-025-08065-2,https://pubmed.ncbi.nlm.nih.gov/41120255/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,39956902,"Tumor-derived exosomal KPNA2 activates fibroblasts and interacts with KIFC1 to promote bladder cancer progression, a process inhibited by miR-26b-5p.",2025,10.1186/s11658-025-00687-w,https://pubmed.ncbi.nlm.nih.gov/39956902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,40665355,Bioinformatics analysis and experimental studies reveal KPNA2 as a novel biomarker of hepatocellular carcinoma progression and telomere maintenance.,2025,10.1186/s40001-025-02866-z,https://pubmed.ncbi.nlm.nih.gov/40665355/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,40912513,KPNA2 expression as a biomarker for immunosuppressive microenvironment predicting response to TKI and immunotherapy in metastatic renal cell carcinoma.,2025,10.1016/j.ejphar.2025.178120,https://pubmed.ncbi.nlm.nih.gov/40912513/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,41896559,High-risk EBV promotes immune evasion in nasopharyngeal carcinoma by upregulating HLA-DP via the encoded BALF2-HR variant.,2026,10.1038/s41467-026-70725-4,https://pubmed.ncbi.nlm.nih.gov/41896559/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,39624961,Multi-omics profiling highlights karyopherin subunit alpha 2 as a promising biomarker for prognosis and immunotherapy respond in pediatric and adult adrenocortical carcinoma.,2024,10.1080/07853890.2024.2397092,https://pubmed.ncbi.nlm.nih.gov/39624961/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,42105160,Identification and validation of a Golgi apparatus related gene signature for prognosis prediction and immune microenvironment profiling in colorectal cancer.,2026,10.1007/s12672-026-05156-0,https://pubmed.ncbi.nlm.nih.gov/42105160/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,39966861,G2M-checkpoint related immune barrier structure and signature for prognosis and immunotherapy response in hepatocellular carcinoma: insights from spatial transcriptome and machine learning.,2025,10.1186/s12967-024-06051-4,https://pubmed.ncbi.nlm.nih.gov/39966861/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,41674779,"TMEM106C, BSG, COPE, CDCA8, KPNA2, LIG1, UQCRH, and CCT5: Predictive of Survival and Immunotherapy Resistance in Hepatocellular Carcinoma.",2026,10.1155/humu/1465989,https://pubmed.ncbi.nlm.nih.gov/41674779/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,39891383,Super-Enhancer Protects Cells From Toxicity of C9orf72 Poly(proline-arginine) by Inducing the Expression of KPNA2/KPNB1.,2025,10.1002/cbf.70053,https://pubmed.ncbi.nlm.nih.gov/39891383/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,41555384,Radiogenomics predicts immune microenvironment heterogeneity and response to combination immunotherapy in hepatocellular carcinoma.,2026,10.1186/s12967-025-07627-4,https://pubmed.ncbi.nlm.nih.gov/41555384/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,38410201,Preparation of hepatocellular carcinoma mRNA vaccines based on potential tumor targets and immunophenotypes.,2024,10.21037/tcr-23-1237,https://pubmed.ncbi.nlm.nih.gov/38410201/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,40216969,KPNA2 promotes osteosarcoma progression by regulating the alternative splicing of DDX3X mediated by YBX1.,2025,10.1038/s41388-025-03375-3,https://pubmed.ncbi.nlm.nih.gov/40216969/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA2,ENSG00000182481,Unsafe,39060340,KPNA2 promotes the progression of gastric cancer by regulating the alternative splicing of related genes.,2024,10.1038/s41598-024-66678-7,https://pubmed.ncbi.nlm.nih.gov/39060340/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA5,ENSG00000196911,Unsafe,40816766,&lt;i&gt;MiR-153&lt;/i&gt; Prevents NRF2 Nuclear Translocation to Drive Hypoperfusion-Related Cognitive Deficits by Targeting &lt;i&gt;KPNA5&lt;/i&gt;.,2025,10.1523/jneurosci.2148-24.2025,https://pubmed.ncbi.nlm.nih.gov/40816766/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA5,ENSG00000196911,Unsafe,40145330,KPNA5 Suppresses Malignant Progression of Ovarian Cancer Through Importing the PTPN4 Into the Nucleus.,2025,10.1002/cam4.70731,https://pubmed.ncbi.nlm.nih.gov/40145330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA5,ENSG00000196911,Unsafe,42235722,Genome-wide association analysis for resistance against iridovirus disease in large yellow croaker (Larimichthys crocea) from a natural outbreak population.,2026,10.1016/j.fsi.2026.111469,https://pubmed.ncbi.nlm.nih.gov/42235722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA5,ENSG00000196911,Unsafe,40872766,The Biophysical Basis for Karyopherin-Dependent Ebola Virus VP24 Nuclear Transport.,2025,10.3390/v17081051,https://pubmed.ncbi.nlm.nih.gov/40872766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA5,ENSG00000196911,Unsafe,42611748,CCL4 as a Potential Immune-Metabolic Biomarker in Acute Myocardial Infarction via Machine Learning and Single-Cell Transcriptomics.,2026,10.3791/72480,https://pubmed.ncbi.nlm.nih.gov/42611748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA5,ENSG00000196911,Unsafe,37259332,LncRNA SNHG6 Upregulates KPNA5 to Overcome Gemcitabine Resistance in Pancreatic Cancer via Sponging miR-944.,2023,10.3390/ph16020184,https://pubmed.ncbi.nlm.nih.gov/37259332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA5,ENSG00000196911,Unsafe,40053206,Mesenchymal Stem Cell-Derived Exosome miR-153-3 Induced M2-Type Polarization of Macrophages to Improve the Healing Effect of Burn Wounds.,2025,10.1007/s12010-025-05196-2,https://pubmed.ncbi.nlm.nih.gov/40053206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA5,ENSG00000196911,Unsafe,35991543,Comprehensive analysis of karyopherin alpha family expression in lung adenocarcinoma: Association with prognostic value and immune homeostasis.,2022,10.3389/fgene.2022.956314,https://pubmed.ncbi.nlm.nih.gov/35991543/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA5,ENSG00000196911,Unsafe,33553736,Molecular profiling of nucleocytoplasmic transport factor genes in breast cancer.,2021,10.1016/j.heliyon.2021.e06039,https://pubmed.ncbi.nlm.nih.gov/33553736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA5,ENSG00000196911,Unsafe,34696514,Effect of Ivermectin and Atorvastatin on Nuclear Localization of Importin Alpha and Drug Target Expression Profiling in Host Cells from Nasopharyngeal Swabs of SARS-CoV-2- Positive Patients.,2021,10.3390/v13102084,https://pubmed.ncbi.nlm.nih.gov/34696514/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA5,ENSG00000196911,Unsafe,26029164,Global Characteristics of CSIG-Associated Gene Expression Changes in Human HEK293 Cells and the Implications for CSIG Regulating Cell Proliferation and Senescence.,2015,10.3389/fendo.2015.00069,https://pubmed.ncbi.nlm.nih.gov/26029164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA5,ENSG00000196911,Unsafe,26052702,BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells.,2015,10.1371/journal.pone.0127707,https://pubmed.ncbi.nlm.nih.gov/26052702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA5,ENSG00000196911,Unsafe,25121748,Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.,2014,10.1016/j.chom.2014.07.008,https://pubmed.ncbi.nlm.nih.gov/25121748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA5,ENSG00000196911,Unsafe,27974555,"VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability.",2017,10.1128/jvi.01715-16,https://pubmed.ncbi.nlm.nih.gov/27974555/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA5,ENSG00000196911,Unsafe,22302350,"Somatic mutations in the Notch, NF-KB, PIK3CA, and Hedgehog pathways in human breast cancers.",2012,10.1002/gcc.21935,https://pubmed.ncbi.nlm.nih.gov/22302350/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA5,ENSG00000196911,Unsafe,25695524,Cross-platform meta-analysis of multiple gene expression profiles identifies novel expression signatures in acquired anthracycline-resistant breast cancer.,2015,10.3892/or.2015.3810,https://pubmed.ncbi.nlm.nih.gov/25695524/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KPNA5,ENSG00000196911,Unsafe,26255028,Lloviu virus VP24 and VP35 proteins function as innate immune antagonists in human and bat cells.,2015,10.1016/j.virol.2015.07.010,https://pubmed.ncbi.nlm.nih.gov/26255028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRBOX1,ENSG00000240747,Unsafe,34204705,In Silico Identification of miRNA-lncRNA Interactions in Male Reproductive Disorder Associated with COVID-19 Infection.,2021,10.3390/cells10061480,https://pubmed.ncbi.nlm.nih.gov/34204705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRBOX1,ENSG00000240747,Unsafe,33015181,Comprehensive Analysis of Differential Immunocyte Infiltration and Potential ceRNA Networks Involved in the Development of Atrial Fibrillation.,2020,10.1155/2020/8021208,https://pubmed.ncbi.nlm.nih.gov/33015181/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRBOX1,ENSG00000240747,Unsafe,28593875,"Intrauterine growth restriction and placental gene expression in severe preeclampsia, comparing early-onset and late-onset forms.",2017,10.1515/jpm-2016-0406,https://pubmed.ncbi.nlm.nih.gov/28593875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRBOX1,ENSG00000240747,Unsafe,28721901,PSMB8 as a Candidate Marker of Responsiveness to Preoperative Radiation Therapy in Rectal Cancer Patients.,2017,10.1016/j.ijrobp.2017.03.023,https://pubmed.ncbi.nlm.nih.gov/28721901/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,42765771,Loss of arap3 drives a cerebral cavernous malformation-like phenotype in zebrafish via Krit1 interaction and RhoA dysregulation.,2026,10.1242/dev.205762,https://pubmed.ncbi.nlm.nih.gov/42765771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,42785997,Loss-Of-Function CCM Gene Variants in Japanese Patients With Cerebral Cavernous Malformations.,2026,10.1111/cge.70253,https://pubmed.ncbi.nlm.nih.gov/42785997/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,42888837,KRIT1 Inhibits TGF-β/Smad-Mediated Endothelial-To-Mesenchymal Transition in Pulmonary Arterial Hypertension.,2026,10.1111/1440-1681.70161,https://pubmed.ncbi.nlm.nih.gov/42888837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,42098603,Identification of the adhesion GPCR ADGRL4/ELTD1 as a novel potential prognostic biomarker for cerebral cavernous malformation disease.,2026,10.1186/s10020-026-01495-4,https://pubmed.ncbi.nlm.nih.gov/42098603/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,42755143,Pediatric Familial Cerebral Cavernous Malformation Associated With a Novel KRIT1 Initiation-Region Frameshift Variant.,2026,10.1002/mgg3.70304,https://pubmed.ncbi.nlm.nih.gov/42755143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,40401429,Improving genetic diagnostic yield in familial and sporadic cerebral cavernous malformations: detection of copy number and deep Intronic variants.,2025,10.1093/hmg/ddaf077,https://pubmed.ncbi.nlm.nih.gov/40401429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,42410678,Endothelial estrogen receptor alpha (ESR1) regulates cerebral cavernous malformation pathogenesis via MEKK3-KLF signaling pathway.,2026,10.1177/0271678x261468891,https://pubmed.ncbi.nlm.nih.gov/42410678/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,42867505,Structure-based discovery of acridone alkaloids as disruptors of the HEG1-KRIT1 protein-protein interaction in cerebral cavernous malformation signaling.,2026,10.1007/s00044-026-03627-1,https://pubmed.ncbi.nlm.nih.gov/42867505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,42108323,KRIT1 nuclear localization does not impair KRIT1-dependent regulation of endothelial barrier permeability and cell homeostasis.,2026,10.1111/febs.70579,https://pubmed.ncbi.nlm.nih.gov/42108323/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,42495466,Partial Oculomotor Nerve Palsy Revealing PDCD10-Related Familial Cerebral Cavernous Malformation in a Child.,2026,10.7759/cureus.111335,https://pubmed.ncbi.nlm.nih.gov/42495466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,42521140,Rebastinib inhibits cerebral cavernous malformation in a chronic mouse model.,2026,10.1016/j.ejphar.2026.179186,https://pubmed.ncbi.nlm.nih.gov/42521140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,41455707,Circumferential actomyosin bundles anchored by CCM1 drive endothelial cell contraction and vessel constriction.,2025,10.1038/s41467-025-67820-3,https://pubmed.ncbi.nlm.nih.gov/41455707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,42859354,"Cerebral cavernous malformations: epidemiology, molecular pathogenesis, diagnosis and therapy.",2026,10.1186/s43556-026-00619-w,https://pubmed.ncbi.nlm.nih.gov/42859354/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,40917023,Unraveling Etiological Indications and Therapeutic Implications of Familial Cerebral Cavernous Malformations in the Dawn of Gene Therapy for Monogenic Conditions.,2025,10.2174/0115665232386151250812105845,https://pubmed.ncbi.nlm.nih.gov/40917023/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,41688454,Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression.,2026,10.1038/s41467-026-69595-7,https://pubmed.ncbi.nlm.nih.gov/41688454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,42265707,Human stem cell models in cerebral cavernous malformations.,2026,10.1186/s13287-026-05081-7,https://pubmed.ncbi.nlm.nih.gov/42265707/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,42216960,Gene burden meta-analysis of 748 879 individuals identifies LGI1-ADAM23 protein complex association with epilepsy.,2026,10.1002/epi.70299,https://pubmed.ncbi.nlm.nih.gov/42216960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,42144952,Knockin expression of human ADAMTS5 impairs cardiovascular development and aggravates cerebral cavernous malformations in mice.,2026,10.1242/dmm.052668,https://pubmed.ncbi.nlm.nih.gov/42144952/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,42074063,Unveiling a Novel Molecular Interaction and Pro-Metastatic Signaling Cascades Driven by KRIT1.,2026,10.3390/ijms27083419,https://pubmed.ncbi.nlm.nih.gov/42074063/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,42341528,Compound Danshen Dripping Pills retards the progression of cerebral cavernous malformations via strengthening vascular integrity and ameliorating inflammatory response.,2026,10.1016/j.phymed.2026.158472,https://pubmed.ncbi.nlm.nih.gov/42341528/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,41561324,Natural history of familial cerebral cavernous malformations: the CCM_Italia cohort study.,2025,10.3389/fneur.2025.1668098,https://pubmed.ncbi.nlm.nih.gov/41561324/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,38612762,Molecular and Cellular Characterization of Primary Endothelial Cells from a Familial Cavernomatosis Patient.,2024,10.3390/ijms25073952,https://pubmed.ncbi.nlm.nih.gov/38612762/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,40360762,Focused ultrasound-microbubble treatment arrests the growth and formation of cerebral cavernous malformations.,2025,10.1038/s41551-025-01390-z,https://pubmed.ncbi.nlm.nih.gov/40360762/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,35444609,A Chinese Family With Cerebral Cavernous Malformation Caused by a Frameshift Mutation of the CCM1 Gene: A Case Report and Review of the Literature.,2022,10.3389/fneur.2022.795514,https://pubmed.ncbi.nlm.nih.gov/35444609/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,41618979,The Role of Immune Infiltration and Oxidative Stress in the Progression of Cerebral Cavernous Malformation.,2026,10.1002/brb3.71237,https://pubmed.ncbi.nlm.nih.gov/41618979/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,38980708,KRIT1 in vascular biology and beyond.,2024,10.1042/bsr20231675,https://pubmed.ncbi.nlm.nih.gov/38980708/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,42650038,Intramedullary Spinal Cord Cavernous Angiomas in Familial Cerebral Cavernous Malformations.,2026,10.3390/genes17080845,https://pubmed.ncbi.nlm.nih.gov/42650038/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,37019926,Impaired retinoic acid signaling in cerebral cavernous malformations.,2023,10.1038/s41598-023-31905-0,https://pubmed.ncbi.nlm.nih.gov/37019926/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,33495402,Modeling paraquat-induced lung fibrosis in C. elegans reveals KRIT1 as a key regulator of collagen gene transcription.,2021,10.18632/aging.202406,https://pubmed.ncbi.nlm.nih.gov/33495402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,35883785,Next-Generation Sequencing Advances the Genetic Diagnosis of Cerebral Cavernous Malformation (CCM).,2022,10.3390/antiox11071294,https://pubmed.ncbi.nlm.nih.gov/35883785/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,38113759,Circulating biomarkers in familial cerebral cavernous malformation.,2024,10.1016/j.ebiom.2023.104914,https://pubmed.ncbi.nlm.nih.gov/38113759/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,36831015,Multidrug-Loaded Lipid Nanoemulsions for the Combinatorial Treatment of Cerebral Cavernous Malformation Disease.,2023,10.3390/biomedicines11020480,https://pubmed.ncbi.nlm.nih.gov/36831015/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,40383158,Focused ultrasound augments the delivery and penetration of model therapeutics into cerebral cavernous malformations.,2025,10.1016/j.jconrel.2025.113861,https://pubmed.ncbi.nlm.nih.gov/40383158/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,40206742,Reproducible occurrence of hiccups during resection of a large pontine cavernous malformation.,2025,10.25259/sni_96_2025,https://pubmed.ncbi.nlm.nih.gov/40206742/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRIT1,ENSG00000001631,Unsafe,9285558,"Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22.",1997,10.1038/sj.onc.1201268,https://pubmed.ncbi.nlm.nih.gov/9285558/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,42511034,Exploring the Cyclic Patterns of Secondary Hair Follicles in Cashmere Goats Based on Skin Transcriptome Data.,2026,10.3390/ani16142156,https://pubmed.ncbi.nlm.nih.gov/42511034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,41096925,Integrated Meta-Analysis of Scalp Transcriptomics and Serum Proteomics Defines Alopecia Areata Subtypes and Core Disease Pathways.,2025,10.3390/ijms26199662,https://pubmed.ncbi.nlm.nih.gov/41096925/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,42488550,Artemisia pollen-induced allergic rhinitis in mice: multi-omics dissection of local and systemic molecular alterations.,2026,10.3389/falgy.2026.1835987,https://pubmed.ncbi.nlm.nih.gov/42488550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,41426600,Diagnosis and treatment of isolated autosomal recessive woolly hair/hypotrichosis.,2025,10.3389/fmed.2025.1605851,https://pubmed.ncbi.nlm.nih.gov/41426600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,41427131,Transcriptome sequencing reveals the key genes associated with hair follicle development in Qianhua Mutton Merino.,2025,10.3389/fvets.2025.1699868,https://pubmed.ncbi.nlm.nih.gov/41427131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,40011909,A comparative proteomic-based study identifies essential factors involved in hair follicle growth in inner Mongolia cashmere goats.,2025,10.1186/s12917-025-04608-z,https://pubmed.ncbi.nlm.nih.gov/40011909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,40029831,Understanding the early molecular changes associated with radiation therapy-A preliminary bulk RNA sequencing study.,2025,10.1371/journal.pone.0316443,https://pubmed.ncbi.nlm.nih.gov/40029831/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,38971547,Study on the expression patterns of inner root sheath-specific genes in Tan sheep hair follicle during different developmental stages.,2024,10.1016/j.gene.2024.148751,https://pubmed.ncbi.nlm.nih.gov/38971547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,36193053,The mRNA Expression Profile of Psoriatic Lesion Distinct from Non-Lesion.,2022,10.2147/ccid.s385894,https://pubmed.ncbi.nlm.nih.gov/36193053/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,36630508,DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation.,2023,10.1126/sciadv.abo7605,https://pubmed.ncbi.nlm.nih.gov/36630508/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,37466550,Association of rs142548867 (EEFSEC) and periodontitis Grade C in a young Brazilian population.,2023,10.1590/1678-7757-2023-0058,https://pubmed.ncbi.nlm.nih.gov/37466550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,38818404,Case report: Exploring autosomal recessive woolly hair: genetic and scanning electron microscopic perspectives on a Japanese patient.,2024,10.3389/fmed.2024.1374222,https://pubmed.ncbi.nlm.nih.gov/38818404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,36482306,Construction of transcriptome atlas of white yak hair follicle during anagen and catagen using single-cell RNA sequencing.,2022,10.1186/s12864-022-09003-8,https://pubmed.ncbi.nlm.nih.gov/36482306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,38873117,"Whole-genome resequencing reveals genetic diversity, differentiation, and selection signatures of yak breeds/populations in southwestern China.",2024,10.3389/fgene.2024.1382128,https://pubmed.ncbi.nlm.nih.gov/38873117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,36183055,Breast cancer prediction with transcriptome profiling using feature selection and machine learning methods.,2022,10.1186/s12859-022-04965-8,https://pubmed.ncbi.nlm.nih.gov/36183055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,36471949,[Proteomics-based screening of differentially expressed protein in bronchial asthma(syndrome of excessive cold)].,2022,10.19540/j.cnki.cjcmm.20220728.502,https://pubmed.ncbi.nlm.nih.gov/36471949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,34194323,TMT-Based Quantitative Proteomic Analysis Reveals the Effect of Bone Marrow Derived Mesenchymal Stem Cell on Hair Follicle Regeneration.,2021,10.3389/fphar.2021.658040,https://pubmed.ncbi.nlm.nih.gov/34194323/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,35047008,Identification and Verification of Five Potential Biomarkers Related to Skin and Thermal Injury Using Weighted Gene Co-Expression Network Analysis.,2021,10.3389/fgene.2021.781589,https://pubmed.ncbi.nlm.nih.gov/35047008/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,36308435,"Trans-ancestry, Bayesian meta-analysis discovers 20 novel risk loci for inflammatory bowel disease in an African American, East Asian and European cohort.",2023,10.1093/hmg/ddac269,https://pubmed.ncbi.nlm.nih.gov/36308435/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,35672687,Gene network analysis reveals candidate genes related with the hair follicle development in sheep.,2022,10.1186/s12864-022-08552-2,https://pubmed.ncbi.nlm.nih.gov/35672687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,25963336,Genetic variation in uncontrolled childhood asthma despite ICS treatment.,2016,10.1038/tpj.2015.36,https://pubmed.ncbi.nlm.nih.gov/25963336/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,30071007,Brain region-dependent gene networks associated with selective breeding for increased voluntary wheel-running behavior.,2018,10.1371/journal.pone.0201773,https://pubmed.ncbi.nlm.nih.gov/30071007/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,16874310,"K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle.",2006,10.1038/sj.jid.5700494,https://pubmed.ncbi.nlm.nih.gov/16874310/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT25,ENSG00000204897,Unsafe,15617563,The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain.,2004,10.1111/j.1432-0436.2004.07209006.x,https://pubmed.ncbi.nlm.nih.gov/15617563/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT28,ENSG00000173908,Unsafe,42232180,"Dendrobium officinale polysaccharide improves hair regrowth in androgenetic alopecia mice and is associated with coordinated changes in local steroid metabolism, ESR1 activation, and keratin-related follicular responses.",2026,10.3389/fphar.2026.1845814,https://pubmed.ncbi.nlm.nih.gov/42232180/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT28,ENSG00000173908,Unsafe,41096925,Integrated Meta-Analysis of Scalp Transcriptomics and Serum Proteomics Defines Alopecia Areata Subtypes and Core Disease Pathways.,2025,10.3390/ijms26199662,https://pubmed.ncbi.nlm.nih.gov/41096925/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT28,ENSG00000173908,Unsafe,40141352,Proteomics Reveals the Role of PLIN2 in Regulating the Secondary Hair Follicle Cycle in Cashmere Goats.,2025,10.3390/ijms26062710,https://pubmed.ncbi.nlm.nih.gov/40141352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT28,ENSG00000173908,Unsafe,40029831,Understanding the early molecular changes associated with radiation therapy-A preliminary bulk RNA sequencing study.,2025,10.1371/journal.pone.0316443,https://pubmed.ncbi.nlm.nih.gov/40029831/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT28,ENSG00000173908,Unsafe,38971547,Study on the expression patterns of inner root sheath-specific genes in Tan sheep hair follicle during different developmental stages.,2024,10.1016/j.gene.2024.148751,https://pubmed.ncbi.nlm.nih.gov/38971547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT28,ENSG00000173908,Unsafe,36630508,DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation.,2023,10.1126/sciadv.abo7605,https://pubmed.ncbi.nlm.nih.gov/36630508/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT28,ENSG00000173908,Unsafe,37210443,Epigenome-wide association study of diabetic chronic kidney disease progression in the Korean population: the KNOW-CKD study.,2023,10.1038/s41598-023-35485-x,https://pubmed.ncbi.nlm.nih.gov/37210443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT28,ENSG00000173908,Unsafe,38967597,Whole-exome sequencing reveals novel cancer genes and actionable targets in biliary tract cancers in primary sclerosing cholangitis.,2024,10.1097/hc9.0000000000000461,https://pubmed.ncbi.nlm.nih.gov/38967597/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT28,ENSG00000173908,Unsafe,36183055,Breast cancer prediction with transcriptome profiling using feature selection and machine learning methods.,2022,10.1186/s12859-022-04965-8,https://pubmed.ncbi.nlm.nih.gov/36183055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT28,ENSG00000173908,Unsafe,33240606,Integrated analysis of lncRNA and mRNA reveals novel insights into cashmere fineness in Tibetan cashmere goats.,2020,10.7717/peerj.10217,https://pubmed.ncbi.nlm.nih.gov/33240606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT28,ENSG00000173908,Unsafe,31580512,Hair follicle differentiation-specific keratin expression in human basal cell carcinoma.,2020,10.1111/ced.14113,https://pubmed.ncbi.nlm.nih.gov/31580512/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT28,ENSG00000173908,Unsafe,16874310,"K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle.",2006,10.1038/sj.jid.5700494,https://pubmed.ncbi.nlm.nih.gov/16874310/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT28,ENSG00000173908,Unsafe,15617563,The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain.,2004,10.1111/j.1432-0436.2004.07209006.x,https://pubmed.ncbi.nlm.nih.gov/15617563/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT33A,ENSG00000006059,Unsafe,42081981,Nanobubble based sonobiopsy reveals circulating protein signatures of BBB opening in healthy and glioblastoma-bearing mice.,2026,10.1016/j.jconrel.2026.114981,https://pubmed.ncbi.nlm.nih.gov/42081981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT33A,ENSG00000006059,Unsafe,39021977,iTRAQ-based quantitative proteomics revealing the therapeutic mechanism of a medicinal and edible formula YH0618 in reducing doxorubicin-induced alopecia by targeting keratins and TGF-β/Smad3 pathway.,2024,10.1016/j.heliyon.2024.e33051,https://pubmed.ncbi.nlm.nih.gov/39021977/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT33A,ENSG00000006059,Unsafe,39548375,Whole-genome sequencing of copy number variation analysis in Ethiopian cattle reveals adaptations to diverse environments.,2024,10.1186/s12864-024-10936-5,https://pubmed.ncbi.nlm.nih.gov/39548375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT33A,ENSG00000006059,Unsafe,34409023,Human iPS Cell-Derived Cell Aggregates Exhibited Dermal Papilla Cell Properties in in vitro Three-Dimensional Assemblage Mimicking Hair Follicle Structures.,2021,10.3389/fcell.2021.590333,https://pubmed.ncbi.nlm.nih.gov/34409023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT33A,ENSG00000006059,Unsafe,36777505,Clinical features of patients with MTAP-deleted bladder cancer.,2023,,https://pubmed.ncbi.nlm.nih.gov/36777505/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT33A,ENSG00000006059,Unsafe,21554405,Annotation of sheep keratin intermediate filament genes and their patterns of expression.,2011,10.1111/j.1600-0625.2011.01274.x,https://pubmed.ncbi.nlm.nih.gov/21554405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT33A,ENSG00000006059,Unsafe,10391933,The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle.,1999,10.1074/jbc.274.28.19874,https://pubmed.ncbi.nlm.nih.gov/10391933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT33A,ENSG00000006059,Unsafe,15617563,The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain.,2004,10.1111/j.1432-0436.2004.07209006.x,https://pubmed.ncbi.nlm.nih.gov/15617563/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT33A,ENSG00000006059,Unsafe,11279113,Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21.,2001,10.1074/jbc.m100657200,https://pubmed.ncbi.nlm.nih.gov/11279113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT33A,ENSG00000006059,Unsafe,9756910,Characterization of a 190-kilobase pair domain of human type I hair keratin genes.,1998,10.1074/jbc.273.41.26683,https://pubmed.ncbi.nlm.nih.gov/9756910/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT33B,ENSG00000131738,Unsafe,41028529,Bioinformatics and machine learning reveal novel prognostic biomarkers in head and neck squamous cell carcinoma.,2025,10.1007/s13353-025-01018-7,https://pubmed.ncbi.nlm.nih.gov/41028529/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT33B,ENSG00000131738,Unsafe,37986320,Construction and validation of a prognostic model for tongue cancer based on three genes signature.,2023,10.1097/md.0000000000036097,https://pubmed.ncbi.nlm.nih.gov/37986320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT33B,ENSG00000131738,Unsafe,34118380,Revealing transcriptional and post-transcriptional regulatory mechanisms of γ-glutamyl transferase and keratin isoforms as novel cooperative biomarkers in low-grade glioma and glioblastoma multiforme.,2021,10.1016/j.ygeno.2021.06.014,https://pubmed.ncbi.nlm.nih.gov/34118380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT33B,ENSG00000131738,Unsafe,32266223,Investigation of miRNA and mRNA Co-expression Network in Ependymoma.,2020,10.3389/fbioe.2020.00177,https://pubmed.ncbi.nlm.nih.gov/32266223/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT33B,ENSG00000131738,Unsafe,24994782,Testosterone regulates keratin 33B expression in rat penis growth through androgen receptor signaling.,2014,10.4103/1008-682x.129935,https://pubmed.ncbi.nlm.nih.gov/24994782/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT33B,ENSG00000131738,Unsafe,21554405,Annotation of sheep keratin intermediate filament genes and their patterns of expression.,2011,10.1111/j.1600-0625.2011.01274.x,https://pubmed.ncbi.nlm.nih.gov/21554405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT33B,ENSG00000131738,Unsafe,11359384,Expression of type I hair keratins in follicular tumours.,2001,10.1046/j.1365-2133.2001.04185.x,https://pubmed.ncbi.nlm.nih.gov/11359384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT33B,ENSG00000131738,Unsafe,10391933,The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle.,1999,10.1074/jbc.274.28.19874,https://pubmed.ncbi.nlm.nih.gov/10391933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,39863862,Identification of novel cytoskeleton protein involved in spermatogenic cells and sertoli cells of non-obstructive azoospermia based on microarray and bioinformatics analysis.,2025,10.1186/s12920-025-02087-7,https://pubmed.ncbi.nlm.nih.gov/39863862/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,40141352,Proteomics Reveals the Role of PLIN2 in Regulating the Secondary Hair Follicle Cycle in Cashmere Goats.,2025,10.3390/ijms26062710,https://pubmed.ncbi.nlm.nih.gov/40141352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,41257584,Integrated transcriptomic and proteomic analysis reveals molecular mechanisms of melatonin-regulated hair follicle growth in cashmere goats and comparative insights across goat breeds.,2025,10.1186/s12864-025-12263-9,https://pubmed.ncbi.nlm.nih.gov/41257584/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,39674634,Correlation and regression analysis of KRT35 and TCHHL1 functional genes for cashmere fineness in Liaoning cashmere goats.,2024,10.1016/j.jgeb.2024.100434,https://pubmed.ncbi.nlm.nih.gov/39674634/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,40214951,"Transcriptome Analysis Reveals Anti-inflammatory, Antiapoptotic, and Milk Synthesis-Promoting Effects of Lithium Chloride in Bovine Mammary Epithelial Cells.",2025,10.1007/s12011-025-04614-0,https://pubmed.ncbi.nlm.nih.gov/40214951/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,36342464,Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness.,2022,10.7554/elife.76911,https://pubmed.ncbi.nlm.nih.gov/36342464/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,33721346,An integrated scalp and blood biomarker approach suggests the systemic nature of alopecia areata.,2021,10.1111/all.14814,https://pubmed.ncbi.nlm.nih.gov/33721346/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,34753940,Screening of cashmere fineness-related genes and their ceRNA network construction in cashmere goats.,2021,10.1038/s41598-021-01203-8,https://pubmed.ncbi.nlm.nih.gov/34753940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,31580512,Hair follicle differentiation-specific keratin expression in human basal cell carcinoma.,2020,10.1111/ced.14113,https://pubmed.ncbi.nlm.nih.gov/31580512/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,30993080,A systematic simulation-based meta-analytical framework for prediction of physiological biomarkers in alopecia.,2019,10.1186/s40709-019-0094-x,https://pubmed.ncbi.nlm.nih.gov/30993080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,34701287,Divergent Role of Intermediate Filaments in Clinical Outcomes of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma.,2021,10.1016/j.ijrobp.2021.07.1090,https://pubmed.ncbi.nlm.nih.gov/34701287/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,30987022,An Integrated Analysis of Cashmere Fineness lncRNAs in Cashmere Goats.,2019,10.3390/genes10040266,https://pubmed.ncbi.nlm.nih.gov/30987022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,28335821,Differential gene expression profiling of endometrium during the mid-luteal phase of the estrous cycle between a repeat breeder (RB) and non-RB cows.,2017,10.1186/s12958-017-0237-6,https://pubmed.ncbi.nlm.nih.gov/28335821/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,28011715,Generation of Hoxc13 knockout pigs recapitulates human ectodermal dysplasia-9.,2017,10.1093/hmg/ddw378,https://pubmed.ncbi.nlm.nih.gov/28011715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,16292560,The HOXC13-controlled expression of early hair keratin genes in the human hair follicle does not involve TALE proteins MEIS and PREP as cofactors.,2006,10.1007/s00403-005-0623-3,https://pubmed.ncbi.nlm.nih.gov/16292560/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,22583695,Increased HOX C13 expression in metastatic melanoma progression.,2012,10.1186/1479-5876-10-91,https://pubmed.ncbi.nlm.nih.gov/22583695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,26661294,Biomarkers of alopecia areata disease activity and response to corticosteroid treatment.,2016,10.1111/exd.12918,https://pubmed.ncbi.nlm.nih.gov/26661294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,19272529,Expression patterns of keratin intermediate filament and keratin associated protein genes in wool follicles.,2009,10.1016/j.diff.2008.10.009,https://pubmed.ncbi.nlm.nih.gov/19272529/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,16441405,"Expression patterns of hair and epithelial keratins and transcription factors HOXC13, LEF1, and beta-catenin in a malignant pilomatricoma: a histological and immunohistochemical study.",2006,10.1111/j.0303-6987.2006.00308.x,https://pubmed.ncbi.nlm.nih.gov/16441405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,21554405,Annotation of sheep keratin intermediate filament genes and their patterns of expression.,2011,10.1111/j.1600-0625.2011.01274.x,https://pubmed.ncbi.nlm.nih.gov/21554405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT35,ENSG00000197079,Unsafe,8823373,Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5.,1996,10.1111/1523-1747.ep12584243,https://pubmed.ncbi.nlm.nih.gov/8823373/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,42499679,A Comparative Study of Genital Lichen Sclerosus Transcriptomes.,2026,10.32607/actanaturae.27889,https://pubmed.ncbi.nlm.nih.gov/42499679/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,40756706,MicroRNA-31 mediated inhibition of keratin 6 by PSORI-CM01: a novel approach to psoriasis amelioration.,2025,10.3389/fchem.2025.1636529,https://pubmed.ncbi.nlm.nih.gov/40756706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,42747744,Downregulating CHI3L2 via the STAT3 Pathway: The Mechanism of Calcitriol in Suppressing Psoriatic Inflammation and Keratinocyte Hyperproliferation.,2026,10.1111/jcmm.71367,https://pubmed.ncbi.nlm.nih.gov/42747744/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,40148322,Keratin-72 restricts HIV-1 infection in resting CD4&lt;sup&gt;+&lt;/sup&gt; T cells by sequestering capsids in intermediate filaments.,2025,10.1038/s41467-025-58218-2,https://pubmed.ncbi.nlm.nih.gov/40148322/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,40941372,Screening of Protein Related to Wool Development and Fineness in Gansu Alpine Fine-Wool Sheep.,2025,10.3390/ani15172578,https://pubmed.ncbi.nlm.nih.gov/40941372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,39513911,"Knockdown of Keratin 6 Within Arsenite-Transformed Human Urothelial Cells Decreases Basal/Squamous Expression, Inhibits Growth, and Increases Cisplatin Sensitivity.",2024,10.3390/cells13211803,https://pubmed.ncbi.nlm.nih.gov/39513911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,42313509,Integrated Bioinformatics Methods Were Employed to Investigate Potential Molecular Links Between Obstructive Sleep Apnea and Sarcoidosis.,2026,10.1155/mi/7909167,https://pubmed.ncbi.nlm.nih.gov/42313509/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,41120280,"CD271 orchestrates skin structure, differentiation, and inflammation via PI3K/Akt and PKCα/ERK pathways.",2025,10.1038/s41419-025-08062-5,https://pubmed.ncbi.nlm.nih.gov/41120280/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,39000463,Assessment of Concentration KRT6 Proteins in Tumor and Matching Surgical Margin from Patients with Head and Neck Squamous Cell Carcinoma.,2024,10.3390/ijms25137356,https://pubmed.ncbi.nlm.nih.gov/39000463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,41904508,Research based on serine metabolism indicates mesenchymal stem cells alleviate psoriasis by regulating the PSPH-PINK1-Parkin-NLRP3 pathway in HaCaT.,2026,10.1186/s13287-026-04964-z,https://pubmed.ncbi.nlm.nih.gov/41904508/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,38398015,"Arecoline Induces ROS Accumulation, Transcription of Proinflammatory Factors, and Expression of KRT6 in Oral Epithelial Cells.",2024,10.3390/biomedicines12020412,https://pubmed.ncbi.nlm.nih.gov/38398015/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,40497153,HIV-1 latency: From acquaintance to confidant.,2025,10.1016/j.jve.2025.100597,https://pubmed.ncbi.nlm.nih.gov/40497153/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,40356407,A genome-wide association study using HapMap cell lines reveals modulators of cellular response to cyclophosphamide.,2025,10.1080/14796694.2025.2501517,https://pubmed.ncbi.nlm.nih.gov/40356407/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,41533904,Establishment of Mouse Meibomian Gland Organoids for In Vitro Modeling of Meibomian Gland Dysfunction.,2026,10.1167/iovs.67.1.6,https://pubmed.ncbi.nlm.nih.gov/41533904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,41695674,Investigating RNA-Seq-based differential gene expression during hair follicle development in Angora goat skin.,2026,10.5187/jast.2024.e104,https://pubmed.ncbi.nlm.nih.gov/41695674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,40406126,"Identification and validation of shared biomarkers and drug repurposing in psoriasis and Crohn's disease: integrating bioinformatics, machine learning, and experimental approaches.",2025,10.3389/fimmu.2025.1587705,https://pubmed.ncbi.nlm.nih.gov/40406126/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,41479908,Keratinocytes as active regulators of cutaneous and mucosal immunity: a systematic review across inflammatory epithelial disorders.,2025,10.3389/fimmu.2025.1694066,https://pubmed.ncbi.nlm.nih.gov/41479908/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,38848163,LncRNA MIR181A2HG inhibits keratinocytes proliferation through miR-223-3p/SOX6 axis.,2024,10.18632/aging.205902,https://pubmed.ncbi.nlm.nih.gov/38848163/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,38736729,LncRNA MIR181A2HG negatively regulates human keratinocytes proliferation by binding SRSF1.,2024,10.1007/s10616-024-00621-6,https://pubmed.ncbi.nlm.nih.gov/38736729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,38971547,Study on the expression patterns of inner root sheath-specific genes in Tan sheep hair follicle during different developmental stages.,2024,10.1016/j.gene.2024.148751,https://pubmed.ncbi.nlm.nih.gov/38971547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,40405049,Construction of lung adenocarcinoma subtype and prognosis model based on fatty acid metabolism-related genes.,2025,10.1007/s12672-025-02613-0,https://pubmed.ncbi.nlm.nih.gov/40405049/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,38542234,Integration Analysis of Hair Follicle Transcriptome and Proteome Reveals the Mechanisms Regulating Wool Fiber Diameter in Angora Rabbits.,2024,10.3390/ijms25063260,https://pubmed.ncbi.nlm.nih.gov/38542234/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,40197419,Application of bioinformatics analysis and molecular docking to study the mechanism of Qingying decoction in treating psoriasis.,2025,10.1186/s41065-025-00421-8,https://pubmed.ncbi.nlm.nih.gov/40197419/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,39596928,The Development of a Human Respiratory Mucosa-on-a-Chip Using Human Turbinate-Derived Mesenchymal Stem Cells.,2024,10.3390/medicina60111741,https://pubmed.ncbi.nlm.nih.gov/39596928/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,39941078,Protective and Anti-Inflammatory Effect of Novel Formulation Based on High and Low Molecular Weight Hyaluronic Acid and &lt;i&gt;Salvia haenkei&lt;/i&gt;.,2025,10.3390/ijms26031310,https://pubmed.ncbi.nlm.nih.gov/39941078/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,38114659,Deep learning and transfer learning identify breast cancer survival subtypes from single-cell imaging data.,2023,10.1038/s43856-023-00414-6,https://pubmed.ncbi.nlm.nih.gov/38114659/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,38730432,Single nucleotide polymorphisms in the KRT82 promoter region modulate irregular thickening and patchiness in the dorsal skin of New Zealand rabbits.,2024,10.1186/s12864-024-10370-7,https://pubmed.ncbi.nlm.nih.gov/38730432/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,37752969,Rehmannioside A Inhibits TRAF6/MAPK Pathway and Improves Psoriasis by Interfering with the Interaction of HaCaT Cells with IL-17A.,2023,10.2147/ccid.s430621,https://pubmed.ncbi.nlm.nih.gov/37752969/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,35745784,Structural and Functional Validation of a Full-Thickness Self-Assembled Skin Equivalent for Disease Modeling.,2022,10.3390/pharmaceutics14061211,https://pubmed.ncbi.nlm.nih.gov/35745784/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,16874310,"K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle.",2006,10.1038/sj.jid.5700494,https://pubmed.ncbi.nlm.nih.gov/16874310/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,12648212,"K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle.",2003,10.1046/j.1523-1747.2003.12087.x,https://pubmed.ncbi.nlm.nih.gov/12648212/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT72,ENSG00000170486,Unsafe,11703281,Keratin K6irs is specific to the inner root sheath of hair follicles in mice and humans.,2001,10.1046/j.1365-2133.2001.04463.x,https://pubmed.ncbi.nlm.nih.gov/11703281/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT82,ENSG00000161850,Unsafe,42738533,Integrative Analysis of the Metabolome and Transcriptome Reveals the Mechanism Underlying Differences in Skin Development Between the New Zealand Rabbit and the Rex Rabbit.,2026,10.3390/ani16172746,https://pubmed.ncbi.nlm.nih.gov/42738533/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT82,ENSG00000161850,Unsafe,40814173,Heterozygous KRT32 variant is responsible for autosomal dominant loose anagen hair syndrome.,2025,10.1016/j.xhgg.2025.100495,https://pubmed.ncbi.nlm.nih.gov/40814173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT82,ENSG00000161850,Unsafe,38730432,Single nucleotide polymorphisms in the KRT82 promoter region modulate irregular thickening and patchiness in the dorsal skin of New Zealand rabbits.,2024,10.1186/s12864-024-10370-7,https://pubmed.ncbi.nlm.nih.gov/38730432/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT82,ENSG00000161850,Unsafe,42543795,Proteomics of Cervical Mineralized Diaphragm in Molar Root-Incisor Malformation.,2026,10.1177/00220345261467270,https://pubmed.ncbi.nlm.nih.gov/42543795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT82,ENSG00000161850,Unsafe,40011909,A comparative proteomic-based study identifies essential factors involved in hair follicle growth in inner Mongolia cashmere goats.,2025,10.1186/s12917-025-04608-z,https://pubmed.ncbi.nlm.nih.gov/40011909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT82,ENSG00000161850,Unsafe,35145093,Whole exome sequencing in Alopecia Areata identifies rare variants in KRT82.,2022,10.1038/s41467-022-28343-3,https://pubmed.ncbi.nlm.nih.gov/35145093/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT82,ENSG00000161850,Unsafe,39762742,Screened of long non-coding RNA related to wool development and fineness in Gansu alpine fine-wool sheep.,2025,10.1186/s12864-024-11195-0,https://pubmed.ncbi.nlm.nih.gov/39762742/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT82,ENSG00000161850,Unsafe,38542234,Integration Analysis of Hair Follicle Transcriptome and Proteome Reveals the Mechanisms Regulating Wool Fiber Diameter in Angora Rabbits.,2024,10.3390/ijms25063260,https://pubmed.ncbi.nlm.nih.gov/38542234/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT82,ENSG00000161850,Unsafe,39336745,Identification of Key Proteins Related to Cashmere Fiber Diameter by Integrated Proteomics and Bioinformatic Analyses in the Alpas and Alxa Goat Breeds.,2024,10.3390/genes15091154,https://pubmed.ncbi.nlm.nih.gov/39336745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT82,ENSG00000161850,Unsafe,39178999,MicroRNA expression profiles reveal wool development and fineness regulation in Gansu alpine fine-wool sheep.,2024,10.1016/j.ygeno.2024.110922,https://pubmed.ncbi.nlm.nih.gov/39178999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT82,ENSG00000161850,Unsafe,36928034,Parallel molecular alteration between Alzheimer's disease and major depressive disorder in the human brain dorsolateral prefrontal cortex: an insight from gene expression and methylation profile analyses.,2023,10.1266/ggs.22-00022,https://pubmed.ncbi.nlm.nih.gov/36928034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT82,ENSG00000161850,Unsafe,34409023,Human iPS Cell-Derived Cell Aggregates Exhibited Dermal Papilla Cell Properties in in vitro Three-Dimensional Assemblage Mimicking Hair Follicle Structures.,2021,10.3389/fcell.2021.590333,https://pubmed.ncbi.nlm.nih.gov/34409023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT82,ENSG00000161850,Unsafe,32202667,RNA Sequencing Reveals Cancer-Associated Changes in Laryngeal Cells Exposed to Non-Acid Pepsin.,2021,10.1002/lary.28636,https://pubmed.ncbi.nlm.nih.gov/32202667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT82,ENSG00000161850,Unsafe,25117815,Identification of 33 candidate oncogenes by screening for base-specific mutations.,2014,10.1038/bjc.2014.429,https://pubmed.ncbi.nlm.nih.gov/25117815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT82,ENSG00000161850,Unsafe,21554405,Annotation of sheep keratin intermediate filament genes and their patterns of expression.,2011,10.1111/j.1600-0625.2011.01274.x,https://pubmed.ncbi.nlm.nih.gov/21554405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRT82,ENSG00000161850,Unsafe,11445569,The catalog of human hair keratins. II. Expression of the six type II members in the hair follicle and the combined catalog of human type I and II keratins.,2001,10.1074/jbc.m103305200,https://pubmed.ncbi.nlm.nih.gov/11445569/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP10-1,ENSG00000215455,Unsafe,38141912,Uncommon Protein-Coding Variants Associated With Suicide Attempt in a Diverse Sample of U.S. Army Soldiers.,2024,10.1016/j.biopsych.2023.12.008,https://pubmed.ncbi.nlm.nih.gov/38141912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP10-1,ENSG00000215455,Unsafe,30210606,Analyzing the disease module associated with osteosarcoma via a network- and pathway-based approach.,2018,10.3892/etm.2018.6506,https://pubmed.ncbi.nlm.nih.gov/30210606/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP10-1,ENSG00000215455,Unsafe,15028290,A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3.,2004,10.1016/j.ygeno.2003.09.024,https://pubmed.ncbi.nlm.nih.gov/15028290/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP10-1,ENSG00000215455,Unsafe,14962103,Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21.,2004,10.1046/j.0022-202x.2003.22128.x,https://pubmed.ncbi.nlm.nih.gov/14962103/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP10-2,ENSG00000205445,Unsafe,41969585,Whole-exome sequencing unveils novel potential gene mutations involved in primary renal small cell carcinoma.,2026,10.3892/ol.2026.15556,https://pubmed.ncbi.nlm.nih.gov/41969585/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP10-2,ENSG00000205445,Unsafe,15028290,A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3.,2004,10.1016/j.ygeno.2003.09.024,https://pubmed.ncbi.nlm.nih.gov/15028290/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP10-2,ENSG00000205445,Unsafe,14962103,Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21.,2004,10.1046/j.0022-202x.2003.22128.x,https://pubmed.ncbi.nlm.nih.gov/14962103/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP10-7,ENSG00000272804,Unsafe,15028290,A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3.,2004,10.1016/j.ygeno.2003.09.024,https://pubmed.ncbi.nlm.nih.gov/15028290/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP10-7,ENSG00000272804,Unsafe,14962103,Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21.,2004,10.1046/j.0022-202x.2003.22128.x,https://pubmed.ncbi.nlm.nih.gov/14962103/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP26-1,ENSG00000197683,Unsafe,38293707,Tumour tissue-derived small extracellular vesicles reflect molecular subtypes of bladder cancer.,2024,10.1002/jev2.12402,https://pubmed.ncbi.nlm.nih.gov/38293707/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP26-1,ENSG00000197683,Unsafe,30544028,Noninvasively diagnosing for fetal trisomy 21 by examining heterozygous single nucleotide polymorphisms in the placental specific genes on chromosome 21.,2019,10.1016/j.ejogrb.2018.09.015,https://pubmed.ncbi.nlm.nih.gov/30544028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP26-1,ENSG00000197683,Unsafe,18647308,Characterization and expression analysis of the hair keratin associated protein KAP26.1.,2008,10.1111/j.1365-2133.2008.08743.x,https://pubmed.ncbi.nlm.nih.gov/18647308/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP5-8,ENSG00000241233,Unsafe,37234773,"Identification of lung adenocarcinoma subtypes and predictive signature for prognosis, immune features, and immunotherapy based on immune checkpoint genes.",2023,10.3389/fcell.2023.1060086,https://pubmed.ncbi.nlm.nih.gov/37234773/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP5-8,ENSG00000241233,Unsafe,15144888,Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11.,2004,10.1016/j.bbrc.2004.04.074,https://pubmed.ncbi.nlm.nih.gov/15144888/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP8-1,ENSG00000183640,Unsafe,41695674,Investigating RNA-Seq-based differential gene expression during hair follicle development in Angora goat skin.,2026,10.5187/jast.2024.e104,https://pubmed.ncbi.nlm.nih.gov/41695674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP8-1,ENSG00000183640,Unsafe,31850197,A Diagnostic Panel of DNA Methylation Biomarkers for Lung Adenocarcinoma.,2019,10.3389/fonc.2019.01281,https://pubmed.ncbi.nlm.nih.gov/31850197/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP8-1,ENSG00000183640,Unsafe,22044071,Search for variation in the ovine KAP7-1 and KAP8-1 genes using polymerase chain reaction-single-stranded conformational polymorphism screening.,2012,10.1089/dna.2011.1346,https://pubmed.ncbi.nlm.nih.gov/22044071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP8-1,ENSG00000183640,Unsafe,25279319,"The sheep KAP8-2 gene, a new KAP8 family member that is absent in humans.",2014,10.1186/2193-1801-3-528,https://pubmed.ncbi.nlm.nih.gov/25279319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP8-1,ENSG00000183640,Unsafe,19930592,A whole genome Bayesian scan for adaptive genetic divergence in West African cattle.,2009,10.1186/1471-2164-10-550,https://pubmed.ncbi.nlm.nih.gov/19930592/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
KRTAP9-2,ENSG00000239886,Unsafe,35524260,"Integrated analysis of lncRNAs and mRNAs by RNA-Seq in secondary hair follicle development and cycling (anagen, catagen and telogen) of Jiangnan cashmere goat (Capra hircus).",2022,10.1186/s12917-022-03253-0,https://pubmed.ncbi.nlm.nih.gov/35524260/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,41776049,L1TD1 promotes colorectal mucinous adenocarcinoma progression by enhancing ABCC3 mRNA stability.,2026,10.1038/s41388-026-03716-w,https://pubmed.ncbi.nlm.nih.gov/41776049/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,42106149,Noncanonical Transcription and Splicing Shape the Colorectal Cancer Immunopeptidome in MSI and MSS Tumors.,2026,10.1016/j.mcpro.2026.101581,https://pubmed.ncbi.nlm.nih.gov/42106149/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,41298451,Microprotein PLUM encoded by Lin28b uORF is a cytoplasmic determinant of pluripotency and embryonic development.,2025,10.1038/s41467-025-66297-4,https://pubmed.ncbi.nlm.nih.gov/41298451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,41559028,Post-transcriptional control of endogenous retroviruses by L1td1 suppresses totipotency acquisition in pluripotent stem cells.,2026,10.1038/s41421-025-00864-3,https://pubmed.ncbi.nlm.nih.gov/41559028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,41560347,Comprehensive Profiling of N&lt;sup&gt;6&lt;/sup&gt;-methyladnosine (m&lt;sup&gt;6&lt;/sup&gt;A) Readouts Reveals Novel m&lt;sup&gt;6&lt;/sup&gt;A Readers That Regulate Human Embryonic Stem Cell Differentiation.,2026,10.1002/advs.202510075,https://pubmed.ncbi.nlm.nih.gov/41560347/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,40112032,The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition.,2025,10.7554/elife.96850,https://pubmed.ncbi.nlm.nih.gov/40112032/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,39912397,"Integrated interactome, proteomic and functional analyses reveal molecular pathways driving L1TD1-induced aggressiveness in CNS embryonal tumor cells.",2025,10.1002/1873-3468.70002,https://pubmed.ncbi.nlm.nih.gov/39912397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,38165001,Dissolution of ribonucleoprotein condensates by the embryonic stem cell protein L1TD1.,2024,10.1093/nar/gkad1244,https://pubmed.ncbi.nlm.nih.gov/38165001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,41551280,Saliva Spectral Signature and LINE-1 Methylation in Oral Cells: Impact of Air Pollution in São Paulo State Residents.,2026,10.1155/sci5/6254270,https://pubmed.ncbi.nlm.nih.gov/41551280/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,38922530,Repurposing metformin as a potential anticancer agent using in silico technique.,2024,10.1007/s40199-024-00523-0,https://pubmed.ncbi.nlm.nih.gov/38922530/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,40016701,Exploration of RNA-binding proteins identified RPS27 as a potential regulator associated with Kaposi's sarcoma development.,2025,10.1186/s12885-025-13790-0,https://pubmed.ncbi.nlm.nih.gov/40016701/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,36806387,Identification and characterization of the long non-coding RNA NFIA-AS2 as a novel locus for body mass index in American Indians.,2023,10.1038/s41366-023-01278-5,https://pubmed.ncbi.nlm.nih.gov/36806387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,31337362,L1TD1 - a prognostic marker for colon cancer.,2019,10.1186/s12885-019-5952-2,https://pubmed.ncbi.nlm.nih.gov/31337362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,38083905,Identification of AP002498.1 and LINC01871 as prognostic biomarkers and therapeutic targets for distant metastasis of colorectal adenocarcinoma.,2024,10.1002/cam4.6823,https://pubmed.ncbi.nlm.nih.gov/38083905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,21637830,"ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency.",2011,10.1371/journal.pone.0020461,https://pubmed.ncbi.nlm.nih.gov/21637830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,33670246,Identification and Validation of New Cancer Stem Cell-Related Genes and Their Regulatory microRNAs in Colorectal Cancerogenesis.,2021,10.3390/biomedicines9020179,https://pubmed.ncbi.nlm.nih.gov/33670246/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,28093071,SPAG6 and L1TD1 are transcriptionally regulated by DNA methylation in non-small cell lung cancers.,2017,10.1186/s12943-016-0568-5,https://pubmed.ncbi.nlm.nih.gov/28093071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,36111489,Intra‑tumor heterogeneity of cancer stem cell‑related genes and their potential regulatory microRNAs in metastasizing colorectal carcinoma.,2022,10.3892/or.2022.8408,https://pubmed.ncbi.nlm.nih.gov/36111489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,33473258,Differential gene expression in cisplatin-resistant and -sensitive testicular germ cell tumor cell lines.,2020,10.18632/oncotarget.27844,https://pubmed.ncbi.nlm.nih.gov/33473258/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,26159230,"Embryonic Stem Cell-Related Protein L1TD1 Is Required for Cell Viability, Neurosphere Formation, and Chemoresistance in Medulloblastoma.",2015,10.1089/scd.2015.0052,https://pubmed.ncbi.nlm.nih.gov/26159230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L1TD1,ENSG00000240563,Unsafe,35501592,Effect of Genetic Polymorphism Including NUP153 and SVEP1 on the Pharmacokinetics and Pharmacodynamics of Ticagrelor in Healthy Chinese Subjects.,2022,10.1007/s40261-022-01154-6,https://pubmed.ncbi.nlm.nih.gov/35501592/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L3MBTL4,ENSG00000154655,Unsafe,42523556,&lt;i&gt;L3MBTL4&lt;/i&gt; methylation is a sensitive marker of DNA-PK inhibitor in pancreatic cancer.,2026,10.37349/etat.2026.1002382,https://pubmed.ncbi.nlm.nih.gov/42523556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L3MBTL4,ENSG00000154655,Unsafe,41876459,Epigenetic silencing &lt;i&gt;L3MBTL4&lt;/i&gt; sensitizes esophageal cancer to DNA-PKcs inhibitor.,2026,10.1080/15384047.2026.2646393,https://pubmed.ncbi.nlm.nih.gov/41876459/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L3MBTL4,ENSG00000154655,Unsafe,41694402,Mendelian randomization and transcriptome analysis reveal depression-driven regulatory patterns of the immune microenvironment in myocardial infarction and heart failure.,2026,10.3389/fimmu.2026.1727699,https://pubmed.ncbi.nlm.nih.gov/41694402/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L3MBTL4,ENSG00000154655,Unsafe,39580773,Evaluation of circANKLE2 &amp; circL3MBTL4 -RNAs Expression in Fertile and Infertile Men.,2025,10.1007/s10528-024-10963-7,https://pubmed.ncbi.nlm.nih.gov/39580773/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L3MBTL4,ENSG00000154655,Unsafe,40379722,A novel LncRNA risk model for disulfidptosis-related prognosis prediction and response to chemotherapy in acute myeloid leukemia.,2025,10.1038/s41598-025-01730-8,https://pubmed.ncbi.nlm.nih.gov/40379722/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L3MBTL4,ENSG00000154655,Unsafe,40542702,KDM3A Modulates Biological Processes in Osteoarthritis Cell Models Via the Wnt/β-Catenin Signaling Pathway.,2026,10.1177/19476035251344878,https://pubmed.ncbi.nlm.nih.gov/40542702/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L3MBTL4,ENSG00000154655,Unsafe,37678876,"IL-27-induced, MSC-derived Exosomes Promote MMP3 Expression Through the miR-206/L3MBTL4 Axis in Synovial Fibroblasts.",2023,,https://pubmed.ncbi.nlm.nih.gov/37678876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L3MBTL4,ENSG00000154655,Unsafe,40595878,LncRNAs regulates cell death in osteosarcoma.,2025,10.1038/s41598-025-04440-3,https://pubmed.ncbi.nlm.nih.gov/40595878/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L3MBTL4,ENSG00000154655,Unsafe,39511641,EZH1/2 plays critical roles in oocyte meiosis prophase I in mice.,2024,10.1186/s40659-024-00564-4,https://pubmed.ncbi.nlm.nih.gov/39511641/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L3MBTL4,ENSG00000154655,Unsafe,33381308,p38/JNK Is Required for the Proliferation and Phenotype Changes of Vascular Smooth Muscle Cells Induced by L3MBTL4 in Essential Hypertension.,2020,10.1155/2020/3123968,https://pubmed.ncbi.nlm.nih.gov/33381308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L3MBTL4,ENSG00000154655,Unsafe,31993418,Time-Course Transcriptome Analysis of Gingiva-Derived Mesenchymal Stem Cells Reveals That Fusobacterium nucleatum Triggers Oncogene Expression in the Process of Cell Differentiation.,2019,10.3389/fcell.2019.00359,https://pubmed.ncbi.nlm.nih.gov/31993418/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L3MBTL4,ENSG00000154655,Unsafe,35461379,Whole-genome sequencing analysis of clozapine-induced myocarditis.,2022,10.1038/s41397-022-00271-x,https://pubmed.ncbi.nlm.nih.gov/35461379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L3MBTL4,ENSG00000154655,Unsafe,35401282,Genotypes of Pain and Analgesia in a Randomized Trial of Irritable Bowel Syndrome.,2022,10.3389/fpsyt.2022.842030,https://pubmed.ncbi.nlm.nih.gov/35401282/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L3MBTL4,ENSG00000154655,Unsafe,27480026,Genome Wide Association Study Identifies L3MBTL4 as a Novel Susceptibility Gene for Hypertension.,2016,10.1038/srep30811,https://pubmed.ncbi.nlm.nih.gov/27480026/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L3MBTL4,ENSG00000154655,Unsafe,20698951,"Loss, mutation and deregulation of L3MBTL4 in breast cancers.",2010,10.1186/1476-4598-9-213,https://pubmed.ncbi.nlm.nih.gov/20698951/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L3MBTL4,ENSG00000154655,Unsafe,30697902,Genome-wide association study of inhaled corticosteroid response in admixed children with asthma.,2019,10.1111/cea.13354,https://pubmed.ncbi.nlm.nih.gov/30697902/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
L3MBTL4,ENSG00000154655,Unsafe,26870257,Nine susceptibility loci for hepatitis B virus-related hepatocellular carcinoma identified by a pilot two-stage genome-wide association study.,2016,10.3892/ol.2015.3958,https://pubmed.ncbi.nlm.nih.gov/26870257/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,42000972,Fiber type-specific expression of LACTB leverages a function in oxidative metabolism.,2026,10.1007/s00418-026-02476-8,https://pubmed.ncbi.nlm.nih.gov/42000972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,42863580,"Auriculasin induces LACTB expression to regulate colorectal cancer cell apoptosis, ferroptosis, invasion, and in vivo tumor growth.",2026,10.1016/j.taap.2026.118082,https://pubmed.ncbi.nlm.nih.gov/42863580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,42800840,The role of autoproteolysis and mitoribosomal proteins in the regulation of the mitochondrial LACTB tumor suppressor.,2026,10.1038/s44319-026-00936-9,https://pubmed.ncbi.nlm.nih.gov/42800840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,41527692,The depletion of serine beta-lactamase-like protein (LACTB) ameliorates metabolic dysfunction-associated steatotic liver disease by reducing ubiquitin-mediated degradation of carnitine palmitoyltransferase 2.,2026,10.1111/dom.70483,https://pubmed.ncbi.nlm.nih.gov/41527692/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,41775345,"LINC00852 inhibits colorectal cancer progression by regulating cell apoptosis, epithelial‒mesenchymal transition, invasion, and cuproptosis through miR-1276/LACTB.",2026,10.1080/15476286.2026.2640489,https://pubmed.ncbi.nlm.nih.gov/41775345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,40603395,Study on the regulation of gastric cancer cell apoptosis by LACTB through mitochondrial autophagy pathway.,2025,10.1038/s41598-025-06047-0,https://pubmed.ncbi.nlm.nih.gov/40603395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,41213373,"Acetylated KLF5 inhibits LACTB transcription, mediates mitochondrial dynamics, and regulates colorectal cancer cell stemness and differentiation.",2025,10.1016/j.ijbiomac.2025.148905,https://pubmed.ncbi.nlm.nih.gov/41213373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,40354832,LACTB promotes cell differentiation and inhibits cell proliferation in colorectal cancer.,2025,10.1016/j.bbagen.2025.130816,https://pubmed.ncbi.nlm.nih.gov/40354832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,39941048,The Pivotal Role of LACTB in the Process of Cancer Development.,2025,10.3390/ijms26031279,https://pubmed.ncbi.nlm.nih.gov/39941048/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,41223265,The tumor suppressor LACTB remodels mitochondria to promote cytochrome c release and apoptosis.,2025,10.1126/sciadv.adx7809,https://pubmed.ncbi.nlm.nih.gov/41223265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,41352943,Synthesis of a hemicyanine-based near-infrared fluorescent probe for the diagnosis of pulmonary fibrosis and acute lung injury.,2026,10.1016/j.aca.2025.344906,https://pubmed.ncbi.nlm.nih.gov/41352943/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,40286848,Discovery and biochemical characterization of the D-aspartyl endopeptidase activity of the serine protease LACTB.,2025,10.1016/j.jbc.2025.108549,https://pubmed.ncbi.nlm.nih.gov/40286848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,42366378,Phenotyping of post-fertilization sperm mitophagy determinants discovered in a mammalian gamete-based cell-free system.,2026,10.1186/s40659-026-00713-x,https://pubmed.ncbi.nlm.nih.gov/42366378/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,41518150,"Genetic Insights Into the Central Role of Serine β-Lactamase-Like Protein in Lipid Metabolism, Metabolic Syndrome, and Chronic Kidney Disease.",2026,10.1002/lipd.70032,https://pubmed.ncbi.nlm.nih.gov/41518150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,40711831,A Near-Infrared Fluorescent Probe for Monitoring of LACTB Activity in NSCLC Diagnosis and Therapy.,2025,10.1021/acs.analchem.5c02094,https://pubmed.ncbi.nlm.nih.gov/40711831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,39561766,Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome.,2025,10.1016/j.cmet.2024.10.007,https://pubmed.ncbi.nlm.nih.gov/39561766/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,39047638,LACTB suppresses liver cancer progression through regulation of ferroptosis.,2024,10.1016/j.redox.2024.103270,https://pubmed.ncbi.nlm.nih.gov/39047638/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,40254645,Age-associated reduction in ER-Mitochondrial contacts impairs mitochondrial lipid metabolism and autophagosome formation in the heart.,2025,10.1038/s41418-025-01511-w,https://pubmed.ncbi.nlm.nih.gov/40254645/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,41021591,Machine learning-based transcriptomic analysis identifies NAMPT and SAT1 as potential biomarkers and therapeutic targets in ferroptosis-associated rheumatoid arthritis.,2025,10.1371/journal.pone.0333556,https://pubmed.ncbi.nlm.nih.gov/41021591/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,39324579,SNPs Give LACTB Oncogene-Like Functions and Prompt Tumor Progression via Dual-Regulating p53.,2024,10.1002/advs.202405907,https://pubmed.ncbi.nlm.nih.gov/39324579/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,38787728,Protocol for identifying OXCT1-mediated LACTB succinylation sites in vitro.,2024,10.1016/j.xpro.2024.103088,https://pubmed.ncbi.nlm.nih.gov/38787728/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,38149985,A potential therapeutic approach for gastric cancer: inhibition of LACTB transcript 1.,2023,10.18632/aging.205345,https://pubmed.ncbi.nlm.nih.gov/38149985/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,37216870,Metabolic enzyme Suclg2 maintains tolerogenicity of regulatory dendritic cells diffDCs by suppressing Lactb succinylation.,2023,10.1016/j.jaut.2023.103048,https://pubmed.ncbi.nlm.nih.gov/37216870/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,40920657,Unveiling the mechanism of Pogostemon cablin (Blanco) Benth in treating heat illnesses via network pharmacology and molecular simulation.,2025,10.1371/journal.pone.0331401,https://pubmed.ncbi.nlm.nih.gov/40920657/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,36078157,"LACTB, a Metabolic Therapeutic Target in Clinical Cancer Application.",2022,10.3390/cells11172749,https://pubmed.ncbi.nlm.nih.gov/36078157/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,34819728,Targeted Nanotherapeutics Using LACTB Gene Therapy Against Melanoma.,2021,10.2147/ijn.s331519,https://pubmed.ncbi.nlm.nih.gov/34819728/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,36375842,LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug.,2023,10.26508/lsa.202201510,https://pubmed.ncbi.nlm.nih.gov/36375842/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,35222724,LACTB suppresses carcinogenesis in lung cancer and regulates the EMT pathway.,2022,10.3892/etm.2022.11172,https://pubmed.ncbi.nlm.nih.gov/35222724/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,36282364,LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer.,2023,10.1007/s10495-022-01775-4,https://pubmed.ncbi.nlm.nih.gov/36282364/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,36562402,Circular RNA circ0104103 inhibits colorectal cancer progression through interactions with HuR and miR-373-5p.,2023,10.1111/cas.15695,https://pubmed.ncbi.nlm.nih.gov/36562402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,37937197,Identification of the methotrexate resistance-related diagnostic markers in osteosarcoma via adaptive total variation netNMF and multi-omics datasets.,2023,10.3389/fgene.2023.1288073,https://pubmed.ncbi.nlm.nih.gov/37937197/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,38384969,"Identification and analysis of mitochondria-related central genes in steroid-induced osteonecrosis of the femoral head, along with drug prediction.",2024,10.3389/fendo.2024.1341366,https://pubmed.ncbi.nlm.nih.gov/38384969/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,28475178,LACTB-mediated tumour suppression by increased mitochondrial lipid metabolism.,2017,10.1038/cdd.2017.60,https://pubmed.ncbi.nlm.nih.gov/28475178/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTB,ENSG00000103642,Unsafe,11707067,"Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain.",2001,10.1006/geno.2001.6643,https://pubmed.ncbi.nlm.nih.gov/11707067/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LACTBL1,ENSG00000215906,Unsafe,35021295,Genome-Wide Association Analysis to Search for New Loci Associated with Lifelong Premature Ejaculation Risk in Chinese Male Han Population.,2022,10.5534/wjmh.210084,https://pubmed.ncbi.nlm.nih.gov/35021295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,42685084,Breast cancer prevention by prophylactic Lalba mRNA-LNP vaccination.,2026,10.1073/pnas.2621855123,https://pubmed.ncbi.nlm.nih.gov/42685084/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,42829930,ELF5-Mediated Enhancer-Promoter Interaction Regulates LALBA Expression in Ovine Mammary Gland.,2026,10.1002/advs.78138,https://pubmed.ncbi.nlm.nih.gov/42829930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,41683981,"Expression Patterns of LALBA and Nucleolin and Their Clinical, Prognostic, and Immune Relevance in Breast Cancer Tissues of Mexican Patients.",2026,10.3390/ijms27031561,https://pubmed.ncbi.nlm.nih.gov/41683981/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,42123613,A Multi-Tissue Transcriptomic Atlas of River Buffalo with a Focus on the Genetic Underpinnings of Lactation Performance Across Four Lactation Stages in the Mammary Gland.,2026,10.3390/ijms27094032,https://pubmed.ncbi.nlm.nih.gov/42123613/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,42433325,"Thiamine modulates the mammary inflammation, antioxidant function and lactation performance in lactating sheep under heat-stress conditions.",2026,10.1016/j.aninu.2026.02.007,https://pubmed.ncbi.nlm.nih.gov/42433325/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,42508477,Hybrid transcriptome sequencing uncovers widespread shifts in transcript usage between midlactation and dry-off in goats.,2026,10.3168/jds.2026-28562,https://pubmed.ncbi.nlm.nih.gov/42508477/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,42774683,From candidate genes to whole-genome approaches: current insights into the genetic architecture of ovine milk production and quality traits.,2026,10.1016/j.vas.2026.100870,https://pubmed.ncbi.nlm.nih.gov/42774683/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,41799555,"Microencapsulated Extracts From Banana Flowers Induce Milk Production in Lactating Rats Through Increased α-Lactalbumin, Aquaporin, and Prolactin Levels.",2026,10.1155/sci5/5148782,https://pubmed.ncbi.nlm.nih.gov/41799555/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,42715686,Fourier-transform infrared-based genome-wide association study identifies candidate genes and variants for sow colostrum composition.,2026,10.1016/j.animal.2026.101929,https://pubmed.ncbi.nlm.nih.gov/42715686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,42088853,Shaping Cell Identity: Global Transcriptome and Pathway Shifts during Mouse Mammary Epithelial Cell Differentiation.,2026,10.34133/csbj.0055,https://pubmed.ncbi.nlm.nih.gov/42088853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,40642922,Comparative Single-Cell Transcriptomic Landscape Reveals the Regulatory Mechanisms of Lactation during Selective Breeding in Asian Water Buffalo.,2025,10.1002/advs.202508847,https://pubmed.ncbi.nlm.nih.gov/40642922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,41220986,Comparison of 4 different RNA sources from lactating dairy cows to assess the mammary transcript abundance.,2025,10.3168/jdsc.2025-0768,https://pubmed.ncbi.nlm.nih.gov/41220986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,41733761,Methods for Preserving Human Milk Cellular and Milk Fat Globule RNA.,2026,10.1007/s10911-026-09601-2,https://pubmed.ncbi.nlm.nih.gov/41733761/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,42324760,Biosynthesis of human milk oligosaccharides (HMOs) in glycoengineered human cells.,2026,10.1093/glycob/cwag048,https://pubmed.ncbi.nlm.nih.gov/42324760/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,39199853,A Comparative Analysis of the Gene Expression Profiles in the Mammary Glands of Lactating and Nonlactating Mares at the Second Month of Gestation.,2024,10.3390/ani14162319,https://pubmed.ncbi.nlm.nih.gov/39199853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,40643968,"Candidate gene search for milk production and composition, milk coagulation properties, and milk protein profile in dairy sheep from a New Zealand flock.",2025,10.1080/10495398.2025.2516688,https://pubmed.ncbi.nlm.nih.gov/40643968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,40444108,"Supplementation of dietary &lt;i&gt;Angelica sinensis&lt;/i&gt; extracts to lactating Wuzhishan sows: effects on milk composition, immune function, milk-derived hormones, and related gene expression.",2025,10.3389/fvets.2025.1524258,https://pubmed.ncbi.nlm.nih.gov/40444108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,38729597,Epigenetic impact of hypothyroidism on the functional differentiation of the mammary gland in rats.,2024,10.1016/j.mce.2024.112267,https://pubmed.ncbi.nlm.nih.gov/38729597/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,38122895,Genetic variability among and within domestic Old and New World camels at the α-lactalbumin gene (LALBA) reveals new alleles and polymorphisms responsible for differential expression.,2024,10.3168/jds.2023-23813,https://pubmed.ncbi.nlm.nih.gov/38122895/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,41276594,Comparative detection of selection signatures in indigenous and crossbred Turkish sheep breeds.,2025,10.1038/s41598-025-29969-1,https://pubmed.ncbi.nlm.nih.gov/41276594/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,40775720,Investigation of growth traits in Turkish Merino lambs using multi-locus GWAS approaches: Karacabey Merino.,2025,10.1186/s12917-025-04957-9,https://pubmed.ncbi.nlm.nih.gov/40775720/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,28916248,Breast cancer vaccines delivered by dendritic cell-targeted lentivectors induce potent antitumor immune responses and protect mice from mammary tumor growth.,2017,10.1016/j.vaccine.2017.09.017,https://pubmed.ncbi.nlm.nih.gov/28916248/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,33243201,Polyherbal formula (ASILACT®) induces Milk production in lactating rats through Upregulation of α-Lactalbumin and aquaporin expression.,2020,10.1186/s12906-020-03152-7,https://pubmed.ncbi.nlm.nih.gov/33243201/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,37895281,"Effect of Supplementation with Curcuma longa and Rosmarinus officinalis Extract Mixture on Acute Phase Protein, Cathelicidin, Defensin and Cytolytic Protein Gene Expression in the Livers of Young Castrated Polish White Improved Bucks.",2023,10.3390/genes14101932,https://pubmed.ncbi.nlm.nih.gov/37895281/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,31852463,"Identification of the complete coding cDNAs and expression analysis of B4GALT1, LALBA, ST3GAL5, ST6GAL1 in the colostrum and milk of the Garganica and Maltese goat breeds to reveal possible implications for oligosaccharide biosynthesis.",2019,10.1186/s12917-019-2206-0,https://pubmed.ncbi.nlm.nih.gov/31852463/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,30744372,"A fast and reliable polymerase chain reaction method based on short interspersed nuclear elements detection for the discrimination of buffalo, cattle, goat, and sheep species in dairy products.",2019,10.5713/ajas.18.0459,https://pubmed.ncbi.nlm.nih.gov/30744372/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,32053966,Ductal Carcinoma In Situ Progression in Dog Model of Breast Cancer.,2020,10.3390/cancers12020418,https://pubmed.ncbi.nlm.nih.gov/32053966/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,32724434,Development and validation of a hypoxia-related prognostic signature for breast cancer.,2020,10.3892/ol.2020.11733,https://pubmed.ncbi.nlm.nih.gov/32724434/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,33081164,Fenugreek Stimulates the Expression of Genes Involved in Milk Synthesis and Milk Flow through Modulation of Insulin/GH/IGF-1 Axis and Oxytocin Secretion.,2020,10.3390/genes11101208,https://pubmed.ncbi.nlm.nih.gov/33081164/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,29886827,Amino Acid Metabolism in Dairy Cows and their Regulation in Milk Synthesis.,2019,10.2174/1389200219666180611084014,https://pubmed.ncbi.nlm.nih.gov/29886827/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,31117949,Development and evaluation of a milk protein transcript depletion method for differential transcriptome analysis in mammary gland tissue.,2019,10.1186/s12864-019-5781-3,https://pubmed.ncbi.nlm.nih.gov/31117949/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,29016691,Generation of beta-lactoglobulin knock-out goats using CRISPR/Cas9.,2017,10.1371/journal.pone.0186056,https://pubmed.ncbi.nlm.nih.gov/29016691/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LALBA,ENSG00000167531,Unsafe,29724161,Transcriptional profiling of swine mammary gland during the transition from colostrogenesis to lactogenesis using RNA sequencing.,2018,10.1186/s12864-018-4719-5,https://pubmed.ncbi.nlm.nih.gov/29724161/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,39934925,Small molecule treatment alleviates photoreceptor cilia defects in LCA5-deficient human retinal organoids.,2025,10.1186/s40478-025-01943-y,https://pubmed.ncbi.nlm.nih.gov/39934925/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,40598770,Recovery of cone-mediated vision in Lebercilin associated retinal ciliopathy after gene therapy: One-year results of a phase I/II trial.,2025,10.1016/j.ymthe.2025.06.035,https://pubmed.ncbi.nlm.nih.gov/40598770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,42667617,Mesenchymal drift in ciliopathy iPSC-derived RPE reveals a convergent pathogenic cell state.,2026,10.1016/j.celrep.2026.117906,https://pubmed.ncbi.nlm.nih.gov/42667617/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,37305852,CRISPR-Cas9 correction of a nonsense mutation in &lt;i&gt;LCA5&lt;/i&gt; rescues lebercilin expression and localization in human retinal organoids.,2023,10.1016/j.omtm.2023.05.012,https://pubmed.ncbi.nlm.nih.gov/37305852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,37071472,Gene augmentation of LCA5-associated Leber congenital amaurosis ameliorates bulge region defects of the photoreceptor ciliary axoneme.,2023,10.1172/jci.insight.169162,https://pubmed.ncbi.nlm.nih.gov/37071472/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,40091069,Associations between RetNet gene polymorphisms and the efficacy of orthokeratology for myopia control: a retrospective clinical study.,2025,10.1186/s40662-025-00426-4,https://pubmed.ncbi.nlm.nih.gov/40091069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,39728598,Leber congenital amaurosis: A clinical and genetic study from a tertiary eye care center.,2025,10.4103/ijo.ijo_545_24,https://pubmed.ncbi.nlm.nih.gov/39728598/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,38892339,Four Unique Genetic Variants in Three Genes Account for 62.7% of Early-Onset Severe Retinal Dystrophy in Chile: Diagnostic and Therapeutic Consequences.,2024,10.3390/ijms25116151,https://pubmed.ncbi.nlm.nih.gov/38892339/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,35713440,Prenatal detection of pure proximal 6q14.1 microduplication encompassing LCA5 gene: A variant of likely benign.,2022,10.1097/md.0000000000029369,https://pubmed.ncbi.nlm.nih.gov/35713440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,36114230,The interaction between LC8 and LCA5 reveals a novel oligomerization function of LC8 in the ciliary-centrosome system.,2022,10.1038/s41598-022-19454-4,https://pubmed.ncbi.nlm.nih.gov/36114230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,35128149,Relative preservation of the extramacular retina in LCA5-associated Leber congenital amaurosis.,2022,10.1016/j.ajoc.2022.101260,https://pubmed.ncbi.nlm.nih.gov/35128149/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,39766915,Phenotypic and Genetic Heterogeneity of a Pakistani Cohort of 15 Consanguineous Families Segregating Variants in Leber Congenital Amaurosis-Associated Genes.,2024,10.3390/genes15121646,https://pubmed.ncbi.nlm.nih.gov/39766915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,32428231,Treatment Potential for LCA5-Associated Leber Congenital Amaurosis.,2020,10.1167/iovs.61.5.30,https://pubmed.ncbi.nlm.nih.gov/32428231/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,29673930,Amelioration of Neurosensory Structure and Function in Animal and Cellular Models of a Congenital Blindness.,2018,10.1016/j.ymthe.2018.03.015,https://pubmed.ncbi.nlm.nih.gov/29673930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,38662103,Clinical and genetic studies for a cohort of patients with Leber congenital amaurosis.,2024,10.1007/s00417-024-06450-9,https://pubmed.ncbi.nlm.nih.gov/38662103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,36369640,Molecular background of Leber congenital amaurosis in a Polish cohort of patients-novel variants discovered by NGS.,2023,10.1007/s13353-022-00733-9,https://pubmed.ncbi.nlm.nih.gov/36369640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,33957996,Clinical exome sequencing facilitates the understanding of genetic heterogeneity in Leber congenital amaurosis patients with variable phenotype in southern India.,2021,10.1186/s40662-021-00243-5,https://pubmed.ncbi.nlm.nih.gov/33957996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,35334008,The early-stage triple-negative breast cancer landscape derives a novel prognostic signature and therapeutic target.,2022,10.1007/s10549-022-06537-z,https://pubmed.ncbi.nlm.nih.gov/35334008/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,27067258,Next-generation Sequencing Extends the Phenotypic Spectrum for LCA5 Mutations: Novel LCA5 Mutations in Cone Dystrophy.,2016,10.1038/srep24357,https://pubmed.ncbi.nlm.nih.gov/27067258/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,37240262,Genetic and Clinical Profile of Retinopathies Due to Disease-Causing Variants in Leber Congenital Amaurosis (LCA)-Associated Genes in a Large German Cohort.,2023,10.3390/ijms24108915,https://pubmed.ncbi.nlm.nih.gov/37240262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,25778467,Genetic modifiers of response to glucose-insulin-potassium (GIK) infusion in acute coronary syndromes and associations with clinical outcomes in the IMMEDIATE trial.,2015,10.1038/tpj.2015.10,https://pubmed.ncbi.nlm.nih.gov/25778467/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,19503738,Leber congenital amaurosis caused by Lebercilin (LCA5) mutation: retained photoreceptors adjacent to retinal disorganization.,2009,,https://pubmed.ncbi.nlm.nih.gov/19503738/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,25775262,Homozygosity mapping and targeted sanger sequencing reveal genetic defects underlying inherited retinal disease in families from pakistan.,2015,10.1371/journal.pone.0119806,https://pubmed.ncbi.nlm.nih.gov/25775262/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5,ENSG00000135338,Unsafe,17546029,"Mutations in LCA5, encoding the ciliary protein lebercilin, cause Leber congenital amaurosis.",2007,10.1038/ng2066,https://pubmed.ncbi.nlm.nih.gov/17546029/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5L,ENSG00000157578,Unsafe,40347941,Multitrait GWAS of non-suicidal self-injury and the polygenetic effects on child psychopathology and brain structures.,2025,10.1016/j.xcrm.2025.102119,https://pubmed.ncbi.nlm.nih.gov/40347941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCA5L,ENSG00000157578,Unsafe,34658353,[Quantitative analysis of differential proteins in liver tissues of patients with non-alcoholic steatohepatitis using iTRAQ technology].,2021,10.12122/j.issn.1673-4254.2021.09.13,https://pubmed.ncbi.nlm.nih.gov/34658353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE2D,ENSG00000187223,Unsafe,38065940,Epigenetic priming of an epithelial enhancer by p63 and CTCF controls expression of a skin-restricted gene XP33.,2023,10.1038/s41420-023-01716-3,https://pubmed.ncbi.nlm.nih.gov/38065940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE2D,ENSG00000187223,Unsafe,30669194,[Detection ofmethylated genes related to allergic rhinitis and establishment of methylation profile].,2019,10.13201/j.issn.1001-1781.2019.01.006,https://pubmed.ncbi.nlm.nih.gov/30669194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE2D,ENSG00000187223,Unsafe,35142951,Differential gene expression and network analysis in head and neck squamous cell carcinoma.,2022,10.1007/s11010-022-04379-3,https://pubmed.ncbi.nlm.nih.gov/35142951/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE2D,ENSG00000187223,Unsafe,25600397,RNA/DNA co-analysis from human skin and contact traces--results of a sixth collaborative EDNAP exercise.,2015,10.1016/j.fsigen.2015.01.002,https://pubmed.ncbi.nlm.nih.gov/25600397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCE2D,ENSG00000187223,Unsafe,15854049,Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.,2005,10.1111/j.0022-202x.2005.23699.x,https://pubmed.ncbi.nlm.nih.gov/15854049/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,42151892,Ligand-dependent corepressor suppresses angiogenesis and macrophage infiltration in gliobl astoma microenvironment via MCP-1 down-regulation.,2026,10.1186/s12896-026-01166-6,https://pubmed.ncbi.nlm.nih.gov/42151892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,41289011,Estrogen receptor signaling drives immune evasion and immunotherapy resistance in HR+ breast cancer.,2026,10.1172/jci193153,https://pubmed.ncbi.nlm.nih.gov/41289011/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,42667366,History of childhood trauma enhances the detrimental effects of recent stressors on brain structure and function in major depressive disorder.,2026,10.1007/s00702-026-03273-2,https://pubmed.ncbi.nlm.nih.gov/42667366/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,41576905,An effective alzheimer disease diagnosis using resting state fmri images and broad learning system.,2026,10.1016/j.pscychresns.2025.112133,https://pubmed.ncbi.nlm.nih.gov/41576905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,40083699,Identification of the LCOR-PLCL1 pathway that restrains lipid accumulation and tumor progression in clear cell renal cell carcinoma.,2025,10.7150/ijbs.107981,https://pubmed.ncbi.nlm.nih.gov/40083699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,40163222,The neurobiology of motivational anhedonia in patients with depression.,2025,10.1007/s11682-025-00999-7,https://pubmed.ncbi.nlm.nih.gov/40163222/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,42123445,Multi-Omics Integration Identifies a Six-Gene Diagnostic Signature for Ankylosing Spondylitis via Metabolic-Immune Crosstalk.,2026,10.3390/ijms27093860,https://pubmed.ncbi.nlm.nih.gov/42123445/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,40614461,m6A-methylated TAL1 exacerbates lipid accumulation in ethylene bisdithiocarbamate metabolite-induced anorectal malformations in rat fetuses via miR-205/LCOR signaling.,2025,10.1016/j.ecoenv.2025.118594,https://pubmed.ncbi.nlm.nih.gov/40614461/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,39080376,TOX2 nuclear-cytosol translocation is linked to leukemogenesis of acute T-cell leukemia by repressing TIM3 transcription.,2024,10.1038/s41418-024-01352-z,https://pubmed.ncbi.nlm.nih.gov/39080376/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,41578398,A genome-wide CRISPR/Cas9 screen reveals novel positive regulators of FTY720 sensitivity in acute lymphoblastic leukemia cells.,2026,10.1186/s13104-026-07654-4,https://pubmed.ncbi.nlm.nih.gov/41578398/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,42546633,Gene regulatory network approach to decipher key transcriptional dynamics driving differentiation of induced pluripotent stem cells to neural lineage.,2026,10.1016/j.compbiolchem.2026.109284,https://pubmed.ncbi.nlm.nih.gov/42546633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,39208261,Osteopontin predicts late-time salience network-related functional connectivity in multiple sclerosis.,2024,10.1371/journal.pone.0309563,https://pubmed.ncbi.nlm.nih.gov/39208261/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,37919687,Does right hemisphere compensate for the left in school-age children with large left middle fossa arachnoid cysts?,2023,10.1186/s12887-023-04148-1,https://pubmed.ncbi.nlm.nih.gov/37919687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,39920371,Plasma miRNAs in polycystic ovary syndrome drive endometrial cancer progression: insights into molecular pathways and therapeutic targets.,2025,10.1007/s12672-025-01861-4,https://pubmed.ncbi.nlm.nih.gov/39920371/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,40845546,Auditory network plasticity in tinnitus across the adult lifespan: Insights from fMRI and structural connectivity.,2025,10.1016/j.heares.2025.109406,https://pubmed.ncbi.nlm.nih.gov/40845546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,38372997,Lifetime Exposure to Depression and Neuroimaging Measures of Brain Structure and Function.,2024,10.1001/jamanetworkopen.2023.56787,https://pubmed.ncbi.nlm.nih.gov/38372997/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,34410950,The Expression of NRIP1 and LCOR in Endometrioid Endometrial Cancer.,2021,10.21873/invivo.12545,https://pubmed.ncbi.nlm.nih.gov/34410950/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,37101115,Technical failure rates for biometry between swept-source and older-generation optical coherence methods: a review and meta-analysis.,2023,10.1186/s12886-023-02926-0,https://pubmed.ncbi.nlm.nih.gov/37101115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,35301507,LCOR mediates interferon-independent tumor immunogenicity and responsiveness to immune-checkpoint blockade in triple-negative breast cancer.,2022,10.1038/s43018-022-00339-4,https://pubmed.ncbi.nlm.nih.gov/35301507/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,37467695,"Estrogens receptors, nuclear coactivator 1 and ligand-dependent corepressor expression are altered early during induced ovarian follicular persistence in dairy cattle.",2023,10.1016/j.theriogenology.2023.07.004,https://pubmed.ncbi.nlm.nih.gov/37467695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,42878215,Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy.,2026,10.1002/1878-0261.70344,https://pubmed.ncbi.nlm.nih.gov/42878215/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,35912168,LCOR Reverses Immune-Checkpoint Inhibitors Therapy Resistance Out of IFN Constraint in Triple-Negative Breast Cancer.,2022,10.3389/fonc.2022.911572,https://pubmed.ncbi.nlm.nih.gov/35912168/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,41412836,A novel mechanism of immunoevasion by ER&lt;sup&gt;+&lt;/sup&gt; breast cancer.,2026,10.1016/j.it.2025.12.003,https://pubmed.ncbi.nlm.nih.gov/41412836/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,35349707,SAHA Enhances Differentiation of CD34+CD45+ Hematopoietic Stem and Progenitor Cells from Pluripotent Stem Cells Concomitant with an Increase in Hemogenic Endothelium.,2022,10.1093/stcltm/szac012,https://pubmed.ncbi.nlm.nih.gov/35349707/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,38020758,Development of a diagnostic and risk prediction model for Alzheimer's disease through integration of single-cell and bulk transcriptomic analysis of glutamine metabolism.,2023,10.3389/fnagi.2023.1275793,https://pubmed.ncbi.nlm.nih.gov/38020758/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,28972158,Ligand-dependent corepressor (LCoR) represses the transcription factor C/EBPβ during early adipocyte differentiation.,2017,10.1074/jbc.m117.793984,https://pubmed.ncbi.nlm.nih.gov/28972158/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,35572439,Does lateralizing the glenosphere center of rotation by 4 mm decrease scapular notching in reverse shoulder arthroplasty with a 135° humeral component?,2022,10.1016/j.jseint.2021.12.005,https://pubmed.ncbi.nlm.nih.gov/35572439/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,31784561,Construction of miRNA-target networks using microRNA profiles of CVB3-infected HeLa cells.,2019,10.1038/s41598-019-54188-w,https://pubmed.ncbi.nlm.nih.gov/31784561/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,31683867,ER-Negative Breast Cancer Is Highly Responsive to Cholesterol Metabolite Signalling.,2019,10.3390/nu11112618,https://pubmed.ncbi.nlm.nih.gov/31683867/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,33444859,Weighted gene co-expression network analysis and drug-gene interaction bioinformatics uncover key genes associated with various presentations of malaria infection in African children and major drug candidates.,2021,10.1016/j.meegid.2021.104723,https://pubmed.ncbi.nlm.nih.gov/33444859/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,34193913,Examining early structural and functional brain alterations in postpartum depression through multimodal neuroimaging.,2021,10.1038/s41598-021-92882-w,https://pubmed.ncbi.nlm.nih.gov/34193913/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCOR,ENSG00000196233,Unsafe,12535528,Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms.,2003,10.1016/s1097-2765(03)00014-5,https://pubmed.ncbi.nlm.nih.gov/12535528/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,42511121,Growth-Associated SNPs of the &lt;i&gt;NCAPG&lt;/i&gt;-&lt;i&gt;LCORL&lt;/i&gt; Locus and Divergent Functions of &lt;i&gt;NCAPG&lt;/i&gt; and &lt;i&gt;LCORL&lt;/i&gt; in Chicken SMSCs.,2026,10.3390/ani16142244,https://pubmed.ncbi.nlm.nih.gov/42511121/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,42662699,The Effects of SNPs in the &lt;i&gt;LCORL&lt;/i&gt; and &lt;i&gt;LTBP2&lt;/i&gt; Genes on Comprehensive Performance Traits in Charolais Sheep.,2026,10.1155/vmi/7393976,https://pubmed.ncbi.nlm.nih.gov/42662699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,40369436,Characterizing differences in the muscle transcriptome between cattle with alternative LCORL-NCAPG haplotypes.,2025,10.1186/s12864-025-11665-z,https://pubmed.ncbi.nlm.nih.gov/40369436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,39638124,"Environmental adaptation and genetic insights: Cloning, bioinformatics, and tissue expression analysis of the LCORL gene in Guangxi Partridge Chicken.",2024,10.1016/j.chemosphere.2024.143893,https://pubmed.ncbi.nlm.nih.gov/39638124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,39467326,LCoRL Regulates Growth and Metabolism.,2024,10.1210/endocr/bqae146,https://pubmed.ncbi.nlm.nih.gov/39467326/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,42603395,Integrated Analysis of SNPs and Structural Variations via High-depth Whole-genome Sequencing Reveals the Genetic Architecture and Optimizes Genomic Prediction in Chickens.,2026,10.1016/j.psj.2026.107561,https://pubmed.ncbi.nlm.nih.gov/42603395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,40094447,LCORL and STC2 Variants Increase Body Size and Growth Rate in Cattle and Other Animals.,2025,10.1093/gpbjnl/qzaf025,https://pubmed.ncbi.nlm.nih.gov/40094447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,38790206,Defining a Haplotype Encompassing the LCORL-NCAPG Locus Associated with Increased Lean Growth in Beef Cattle.,2024,10.3390/genes15050576,https://pubmed.ncbi.nlm.nih.gov/38790206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,42436575,Host genetic architecture and gut microbiota cooperatively regulate early growth in goats.,2026,10.1186/s42523-026-00597-y,https://pubmed.ncbi.nlm.nih.gov/42436575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,41596529,"Impact of Mutations in the &lt;i&gt;NCAPG&lt;/i&gt; and &lt;i&gt;MSTN&lt;/i&gt; Genes on Body Composition, Structural Properties of Skeletal Muscle, Its Fatty Acid Composition, and Meat Quality of Bulls from a Charolais × Holstein F&lt;sub&gt;2&lt;/sub&gt; Cross.",2026,10.3390/ijms27020882,https://pubmed.ncbi.nlm.nih.gov/41596529/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,41514823,Weighted Single-Step Genome-Wide Association Study Identifies Candidate Genes for Carcass Traits and Primal Cut Yields in Hanwoo Cattle.,2026,10.3390/ani16010136,https://pubmed.ncbi.nlm.nih.gov/41514823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,42336005,Whole exome sequencing uncovers key genetic variants in congenital tooth agenesis: an integrative omics approach.,2026,10.1016/j.gene.2026.150278,https://pubmed.ncbi.nlm.nih.gov/42336005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,37289743,Ancient segmentally duplicated LCORL retrocopies in equids.,2023,10.1371/journal.pone.0286861,https://pubmed.ncbi.nlm.nih.gov/37289743/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,41859758,Direct single-nucleotide polymorphism genotyping from whole blood without DNA extraction.,2026,10.1294/jes.37.35,https://pubmed.ncbi.nlm.nih.gov/41859758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,40561828,A significant genomic region underlying growth traits in adult Beijing You chicken identified by genome-wide association analysis.,2025,10.1016/j.psj.2025.105326,https://pubmed.ncbi.nlm.nih.gov/40561828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,42731201,Mining of important genetic loci and evaluation of genetic effects for growth traits in Baicheng You Chicken.,2026,10.1016/j.psj.2026.107063,https://pubmed.ncbi.nlm.nih.gov/42731201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,40919429,Genome-wide association study on dairy goat milk production traits using three models.,2025,10.3389/fgene.2025.1650836,https://pubmed.ncbi.nlm.nih.gov/40919429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,40218384,Application of Omics in Donkey Meat Research: A Review.,2025,10.3390/ani15070991,https://pubmed.ncbi.nlm.nih.gov/40218384/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,40127928,Analysis of canine gene constraint identifies new variants for orofacial clefts and stature.,2025,10.1101/gr.280092.124,https://pubmed.ncbi.nlm.nih.gov/40127928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,40604075,Leveraging genome-wide association analyses with chip and imputed data emerges potential pleiotropic region for four duck growth traits.,2025,10.1038/s41598-025-08852-z,https://pubmed.ncbi.nlm.nih.gov/40604075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,42518597,"Genome-wide association study of the reproductive, body size, and carcass-related latent and directly measured traits in admixed beef heifers.",2026,10.3389/fgene.2026.1653878,https://pubmed.ncbi.nlm.nih.gov/42518597/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,40565519,Comparative Genomic Analysis Across Multiple Species to Identify Candidate Genes Associated with Important Traits in Chickens.,2025,10.3390/genes16060627,https://pubmed.ncbi.nlm.nih.gov/40565519/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,41491007,Modeling genotype-by-environment interactions across climatic conditions reveals environment-specific genomic regions and candidate genes underlying feed efficiency traits in tropical beef cattle.,2026,10.1038/s41598-025-33952-1,https://pubmed.ncbi.nlm.nih.gov/41491007/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,35787790,A genome-wide screen for resilient responses in growing pigs.,2022,10.1186/s12711-022-00739-1,https://pubmed.ncbi.nlm.nih.gov/35787790/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,39567870,Assessment of genome complementarity in three beef-on-dairy crossbreds reveals sire-specific effects on production traits with comparable rates of genomic inbreeding reduction.,2024,10.1186/s12864-024-11029-z,https://pubmed.ncbi.nlm.nih.gov/39567870/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,38492250,New insights into the genetic loci related to egg weight and age at first egg traits in broiler breeder.,2024,10.1016/j.psj.2024.103613,https://pubmed.ncbi.nlm.nih.gov/38492250/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,38003134,Genomic Selection for Live Weight in the 14th Month in Alpine Merino Sheep Combining GWAS Information.,2023,10.3390/ani13223516,https://pubmed.ncbi.nlm.nih.gov/38003134/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,34497859,Identification of Immune-Related Risk Signatures for the Prognostic Prediction in Oral Squamous Cell Carcinoma.,2021,10.1155/2021/6203759,https://pubmed.ncbi.nlm.nih.gov/34497859/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,34977215,Comparative Enhancer Map of Cattle Muscle Genome Annotated by ATAC-Seq.,2021,10.3389/fvets.2021.782409,https://pubmed.ncbi.nlm.nih.gov/34977215/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,35021220,Mapping the Cord Blood Transcriptome of Pregnancies Affected by Early Maternal Anemia to Identify Signatures of Fetal Programming.,2022,10.1210/clinem/dgac010,https://pubmed.ncbi.nlm.nih.gov/35021220/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,34906355,A single-nucleotide mutation within the TBX3 enhancer increased body size in Chinese horses.,2022,10.1016/j.cub.2021.11.052,https://pubmed.ncbi.nlm.nih.gov/34906355/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,34834492,Role of Sex on the Genetic Susceptibility to Childhood Asthma in Latinos and African Americans.,2021,10.3390/jpm11111140,https://pubmed.ncbi.nlm.nih.gov/34834492/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,33226152,"Selection in the Finnhorse, a native all-around horse breed.",2021,10.1111/jbg.12524,https://pubmed.ncbi.nlm.nih.gov/33226152/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,34827868,"Insight into the Candidate Genes and Enriched Pathways Associated with Height, Length, Length to Height Ratio and Body-Weight of Korean Indigenous Breed, Jindo Dog Using Gene Set Enrichment-Based GWAS Analysis.",2021,10.3390/ani11113136,https://pubmed.ncbi.nlm.nih.gov/34827868/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,24278337,Adipose and muscle tissue gene expression of two genes (NCAPG and LCORL) located in a chromosomal region associated with cattle feed intake and gain.,2013,10.1371/journal.pone.0080882,https://pubmed.ncbi.nlm.nih.gov/24278337/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,29860282,Genetic study of multimodal imaging Alzheimer's disease progression score implicates novel loci.,2018,10.1093/brain/awy141,https://pubmed.ncbi.nlm.nih.gov/29860282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,32271776,Whole genome detection of sequence and structural polymorphism in six diverse horses.,2020,10.1371/journal.pone.0230899,https://pubmed.ncbi.nlm.nih.gov/32271776/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LCORL,ENSG00000178177,Unsafe,25281659,A novel common variant in DCST2 is associated with length in early life and height in adulthood.,2015,10.1093/hmg/ddu510,https://pubmed.ncbi.nlm.nih.gov/25281659/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LELP1,ENSG00000203784,Unsafe,41613942,Exploring the effect of skim milk on the membrane stability of frozen-thawed Inner Mongolia cashmere goat sperm based on proteomics.,2025,10.3389/fcell.2025.1701830,https://pubmed.ncbi.nlm.nih.gov/41613942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LELP1,ENSG00000203784,Unsafe,37083227,Deciphering the Molecular Characteristics of Human Idiopathic Nonobstructive Azoospermia from the Perspective of Germ Cells.,2023,10.1002/advs.202206852,https://pubmed.ncbi.nlm.nih.gov/37083227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LELP1,ENSG00000203784,Unsafe,34112911,Gene duplications and gene loss in the epidermal differentiation complex during the evolutionary land-to-water transition of cetaceans.,2021,10.1038/s41598-021-91863-3,https://pubmed.ncbi.nlm.nih.gov/34112911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LELP1,ENSG00000203784,Unsafe,26608070,Association of a Single Nucleotide Polymorphism in a Late Cornified Envelope-like Proline-rich 1 Gene (LELP1) with Atopic Dermatitis.,2016,10.2340/00015555-2301,https://pubmed.ncbi.nlm.nih.gov/26608070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LELP1,ENSG00000203784,Unsafe,28119736,Recent Positive Selection in Genes of the Mammalian Epidermal Differentiation Complex Locus.,2016,10.3389/fgene.2016.00227,https://pubmed.ncbi.nlm.nih.gov/28119736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,42017034,Advances in the molecular mechanisms and clinical applications of LEMD1 in tumor development and progression (Review).,2026,10.3892/mco.2026.2948,https://pubmed.ncbi.nlm.nih.gov/42017034/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,42596831,OLR1 promotes cell proliferation and invasion while represses apoptosis via regulating histone H3 lysine 18 lactylation‑mediated LEMD1 in papillary thyroid cancer.,2026,10.3892/or.2026.9178,https://pubmed.ncbi.nlm.nih.gov/42596831/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,42105037,Andrographis restrains the progression of colorectal cancer by inhibiting the KLF3/LEMD1 axis.,2026,10.1007/s10142-026-01877-1,https://pubmed.ncbi.nlm.nih.gov/42105037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,42099394,Nuclear envelope proteins in cancer: revisiting the significance of LEM-domain proteins.,2026,10.3389/fcell.2026.1789623,https://pubmed.ncbi.nlm.nih.gov/42099394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,42606648,Integrative bulk and single-cell transcriptomics identify a recurrence-prognostic risk model with exploratory associations with treatment-response phenotypes in colorectal cancer.,2026,10.1007/s13577-026-01435-8,https://pubmed.ncbi.nlm.nih.gov/42606648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,37296887,LEM Domain Containing 1 Acts as a Novel Oncogene and Therapeutic Target for Triple-Negative Breast Cancer.,2023,10.3390/cancers15112924,https://pubmed.ncbi.nlm.nih.gov/37296887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,38450186,Humoral immunoprofiling identifies novel biomarkers and an immune suppressive autoantibody phenotype at the site of disease in pancreatic ductal adenocarcinoma.,2024,10.3389/fonc.2024.1330419,https://pubmed.ncbi.nlm.nih.gov/38450186/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,35286235,LEM domain containing 1 promotes pancreatic cancer growth and metastasis by p53 and mTORC1 signaling pathway.,2022,10.1080/21655979.2022.2047404,https://pubmed.ncbi.nlm.nih.gov/35286235/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,36967459,Elevation of LEM Domain Containing 1 Predicts Poor Prognosis of NSCLC Patients and Triggers Malignant Stemness and Invasion of NSCLC Cells by Stimulating PI3K/AKT Pathway.,2024,10.2174/1566524023666230324135330,https://pubmed.ncbi.nlm.nih.gov/36967459/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,35983249,Long Noncoding RNA LEMD1-AS1 Increases LEMD1 Expression and Activates PI3K-AKT Pathway to Promote Metastasis in Oral Squamous Cell Carcinoma.,2022,10.1155/2022/3543948,https://pubmed.ncbi.nlm.nih.gov/35983249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,35294319,LEM domain containing 1 (LEMD1) transcriptionally activated by SRY-related high-mobility-group box 4 (SOX4) accelerates the progression of colon cancer by upregulating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway.,2022,10.1080/21655979.2022.2047556,https://pubmed.ncbi.nlm.nih.gov/35294319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,35968498,"Downregulation of LEMD1-AS1 and Its Influences on the Diagnosis, Prognosis, and Immune Infiltrates of Epithelial Ovarian Cancer.",2022,10.1155/2022/6408879,https://pubmed.ncbi.nlm.nih.gov/35968498/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,33868480,LEM domain containing 1 promotes thyroid cancer cell proliferation and migration by activating the Wnt/β-catenin signaling pathway and epithelial-mesenchymal transition.,2021,10.3892/ol.2021.12703,https://pubmed.ncbi.nlm.nih.gov/33868480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,35619906,A Three-Genes Signature Predicting Colorectal Cancer Relapse Reveals LEMD1 Promoting CRC Cells Migration by RhoA/ROCK1 Signaling Pathway.,2022,10.3389/fonc.2022.823696,https://pubmed.ncbi.nlm.nih.gov/35619906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,35686740,LncRNA LEMD1-AS1 relieves chondrocyte inflammation by targeting miR-944/PGAP1 in osteoarthritis.,2022,10.1080/15384101.2022.2084294,https://pubmed.ncbi.nlm.nih.gov/35686740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,34672237,Long non-coding RNA LINC00958 promotes colorectal cancer progression by enhancing the expression of LEM domain containing 1 via microRNA miR-3064-5p.,2021,10.1080/21655979.2021.1985259,https://pubmed.ncbi.nlm.nih.gov/34672237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,32455867,Sushi Repeat Containing Protein X-linked 2 Is a Downstream Signal of LEM Domain Containing 1 and Acts as a Tumor-Promoting Factor in Oral Squamous Cell Carcinoma.,2020,10.3390/ijms21103655,https://pubmed.ncbi.nlm.nih.gov/32455867/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,32801762,LEMD1-AS1 Suppresses Ovarian Cancer Progression Through Regulating miR-183-5p/TP53 Axis.,2020,10.2147/ott.s250850,https://pubmed.ncbi.nlm.nih.gov/32801762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,31021450,LEM domain containing 1 promotes proliferation via activating the PI3K/Akt signaling pathway in gastric cancer.,2019,10.1002/jcb.28783,https://pubmed.ncbi.nlm.nih.gov/31021450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,37528285,Molecular Characterization of Cuproptosis-related lncRNAs: Defining Molecular Subtypes and a Prognostic Signature of Ovarian Cancer.,2024,10.1007/s12011-023-03780-3,https://pubmed.ncbi.nlm.nih.gov/37528285/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,36003381,A novel tumor mutational burden-based risk model predicts prognosis and correlates with immune infiltration in ovarian cancer.,2022,10.3389/fimmu.2022.943389,https://pubmed.ncbi.nlm.nih.gov/36003381/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,35650630,Collective analysis of the expression and prognosis for LEM-domain proteins in prostate cancer.,2022,10.1186/s12957-022-02640-z,https://pubmed.ncbi.nlm.nih.gov/35650630/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,27280633,LEM domain containing 1 promotes oral squamous cell carcinoma invasion and endothelial transmigration.,2016,10.1038/bjc.2016.167,https://pubmed.ncbi.nlm.nih.gov/27280633/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,20682177,"Expression of two testis-specific genes, SPATA19 and LEMD1, in prostate cancer.",2010,10.1016/j.arcmed.2010.04.003,https://pubmed.ncbi.nlm.nih.gov/20682177/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,32549918,Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes.,2020,10.1007/s13167-020-00209-y,https://pubmed.ncbi.nlm.nih.gov/32549918/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,31752878,Transcriptome-wide analysis of changes in the fetal placenta associated with prenatal arsenic exposure in the New Hampshire Birth Cohort Study.,2019,10.1186/s12940-019-0535-x,https://pubmed.ncbi.nlm.nih.gov/31752878/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LEMD1,ENSG00000186007,Unsafe,15254688,"Isolation of LEM domain-containing 1, a novel testis-specific gene expressed in colorectal cancers.",2004,10.3892/or.12.2.275,https://pubmed.ncbi.nlm.nih.gov/15254688/,annotation citations | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,41734713,Hypoxia-induced LGALS8-AS1 sustains oxidative phosphorylation to drive breast cancer progression.,2026,10.1016/j.bbrc.2026.153488,https://pubmed.ncbi.nlm.nih.gov/41734713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,42709286,Genome-wide Identification and Expression Profiling Reveal the Galectin Gene Family Diversity and their Possible Role in Antibacterial Mucosal Immunity in Japanese Flounder (Paralichthys olivaceus).,2026,10.1007/s10126-026-10699-y,https://pubmed.ncbi.nlm.nih.gov/42709286/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,41882123,Multimerin1 and not Galectin-8 tempers WNT signaling to promote gastric chief cell differentiation.,2026,10.1038/s41598-026-43742-y,https://pubmed.ncbi.nlm.nih.gov/41882123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,40375122,Endogenous Galectin-8 protects against Th17 infiltration and fibrosis following acute kidney injury.,2025,10.1186/s10020-025-01245-y,https://pubmed.ncbi.nlm.nih.gov/40375122/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,40489038,Shared hub genes in membranous nephropathy and kidney renal clear cell carcinoma: investigating molecular overlap and tumor progression.,2025,10.1007/s12672-025-02701-1,https://pubmed.ncbi.nlm.nih.gov/40489038/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,42391674,Integrated multi-omics and single-cell analysis of galectins and immune associations in triple-negative breast cancer.,2026,10.1016/j.tranon.2026.102887,https://pubmed.ncbi.nlm.nih.gov/42391674/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,39722688,Insulin like growth factor 2 mRNA binding protein 2 regulates vascular development in cerebral arteriovenous malformations.,2024,10.3389/fneur.2024.1483016,https://pubmed.ncbi.nlm.nih.gov/39722688/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,41020869,Integration of eQTL and GEO Datasets to Identify Genes Associated with Breast Ductal Carcinoma In Situ.,2025,10.3390/cimb47090747,https://pubmed.ncbi.nlm.nih.gov/41020869/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,37716002,Long noncoding RNA LGALS8-AS1 promotes angiogenesis and brain metastases in non-small cell lung cancer.,2023,10.18388/abp.2020_6501,https://pubmed.ncbi.nlm.nih.gov/37716002/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,42264037,Discovery of endothelial cell antibodies associated with pediatric and adult kidney allograft rejection and assessment of a non-human leukocyte antigen antibody assay.,2026,10.1016/j.ajt.2026.05.2304,https://pubmed.ncbi.nlm.nih.gov/42264037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,38395460,Galectin-8 modulates human osteoclast activity partly through isoform-specific interactions.,2024,10.26508/lsa.202302348,https://pubmed.ncbi.nlm.nih.gov/38395460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,37424827,Galectin-8 alters immune microenvironment and promotes tumor progression.,2023,,https://pubmed.ncbi.nlm.nih.gov/37424827/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,34439592,Transcriptomic Data Analysis Reveals a Down-Expression of Galectin-8 in Schizophrenia Hippocampus.,2021,10.3390/brainsci11080973,https://pubmed.ncbi.nlm.nih.gov/34439592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,40119673,Galectin-3 regulates erythropoiesis and enhances the immunoregulatory properties of CD71+ erythroid cells across developmental stages.,2025,10.1093/jimmun/vkaf020,https://pubmed.ncbi.nlm.nih.gov/40119673/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,36807469,Long non-coding RNA LGALS8-AS1 facilitates PLAGL2-mediated malignant phenotypes in gastric cancer.,2023,10.1002/jgm.3487,https://pubmed.ncbi.nlm.nih.gov/36807469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,34745940,LncRNA LGALS8-AS1 Promotes Breast Cancer Metastasis Through miR-125b-5p/SOX12 Feedback Regulatory Network.,2021,10.3389/fonc.2021.711684,https://pubmed.ncbi.nlm.nih.gov/34745940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,39643769,A New Differential Gene Expression Based Simulated Annealing for Solving Gene Selection Problem: A Case Study on Eosinophilic Esophagitis and Few Other Gastro-intestinal Diseases.,2025,10.1007/s10528-024-10987-z,https://pubmed.ncbi.nlm.nih.gov/39643769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,39288719,Citrus pectin modulates chicken peripheral blood mononuclear cell proteome in vitro.,2024,10.1016/j.psj.2024.104293,https://pubmed.ncbi.nlm.nih.gov/39288719/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,36440350,Co-expression network analysis for identification of novel biomarkers of bronchopulmonary dysplasia model.,2022,10.3389/fped.2022.946747,https://pubmed.ncbi.nlm.nih.gov/36440350/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,38470107,"Activation of the lysosomal damage response and selective autophagy: the coordinated actions of galectins, TRIM proteins, and CGAS-STING1 in providing immunity against Mycobacterium tuberculosis.",2025,10.1080/1040841x.2024.2321494,https://pubmed.ncbi.nlm.nih.gov/38470107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,38824843,Epigenetic footprints: Investigating placental DNA methylation in the context of prenatal exposure to phenols and phthalates.,2024,10.1016/j.envint.2024.108763,https://pubmed.ncbi.nlm.nih.gov/38824843/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,34669463,Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension.,2021,10.1126/sciadv.abh3794,https://pubmed.ncbi.nlm.nih.gov/34669463/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,32209695,A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1.,2020,10.1128/mbio.03155-19,https://pubmed.ncbi.nlm.nih.gov/32209695/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,35814469,Prognostic Value and Biological Function of Galectins in Malignant Glioma.,2022,10.3389/fonc.2022.834307,https://pubmed.ncbi.nlm.nih.gov/35814469/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,29258207,Role of Galectins in Multiple Myeloma.,2017,10.3390/ijms18122740,https://pubmed.ncbi.nlm.nih.gov/29258207/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,25649018,Humoral Immune Response against Nontargeted Tumor Antigens after Treatment with Sipuleucel-T and Its Association with Improved Clinical Outcome.,2015,10.1158/1078-0432.ccr-14-2334,https://pubmed.ncbi.nlm.nih.gov/25649018/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,32065482,A risk signature with four autophagy-related genes for predicting survival of glioblastoma multiforme.,2020,10.1111/jcmm.14938,https://pubmed.ncbi.nlm.nih.gov/32065482/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,27280726,Coexpression Network Analysis of Benign and Malignant Phenotypes of SIV-Infected Sooty Mangabey and Rhesus Macaque.,2016,10.1371/journal.pone.0156170,https://pubmed.ncbi.nlm.nih.gov/27280726/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,34675821,Cross-Talk Between Intestinal Microbiota and Host Gene Expression in Gilthead Sea Bream (&lt;i&gt;Sparus aurata&lt;/i&gt;) Juveniles: Insights in Fish Feeds for Increased Circularity and Resource Utilization.,2021,10.3389/fphys.2021.748265,https://pubmed.ncbi.nlm.nih.gov/34675821/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,25115182,Alternative splicing in osteoclasts and Paget's disease of bone.,2014,10.1186/s12881-014-0098-1,https://pubmed.ncbi.nlm.nih.gov/25115182/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LGALS8,ENSG00000116977,Unsafe,28811319,Galectin-8 activates dendritic cells and stimulates antigen-specific immune response elicitation.,2017,10.1189/jlb.3a0816-357rr,https://pubmed.ncbi.nlm.nih.gov/28811319/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,42900719,"&lt;i&gt;Lhx9&lt;/i&gt; specifically modulates phalanx number, whereas &lt;i&gt;Lhx2&lt;/i&gt; constrains digit length in tetrapods.",2026,10.1073/pnas.2605261123,https://pubmed.ncbi.nlm.nih.gov/42900719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,42326002,Evidence of Sertoli cell lineage contribution to the rete testis population during embryonic development.,2026,10.3389/fcell.2026.1849381,https://pubmed.ncbi.nlm.nih.gov/42326002/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,40802848,"Role of Transcription Factor, LIM Homeobox 9 (LHX9) in Inflammatory Response by PGE2 and Thrombin in SERPINA1-Silencing Endometrial Stromal Cells.",2025,10.1002/mrd.70046,https://pubmed.ncbi.nlm.nih.gov/40802848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,42181240,Temporal control of midline crossing via incoherent feedforward and feedback loops regulating Robo3.,2026,10.1016/j.isci.2026.115912,https://pubmed.ncbi.nlm.nih.gov/42181240/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,40056778,Multi-omics joint analysis and identification of candidate genes for the rate of right ovarian degeneration in geese.,2025,10.1016/j.psj.2025.104966,https://pubmed.ncbi.nlm.nih.gov/40056778/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,39753050,Molecular mechanisms of libido influencing semen quality in geese through the hypothalamic-pituitary-testicular-external genitalia axis.,2025,10.1016/j.psj.2024.104756,https://pubmed.ncbi.nlm.nih.gov/39753050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,40712010,The gene regulatory landscape driving mouse gonadal supporting cell differentiation.,2025,10.1126/sciadv.adv1885,https://pubmed.ncbi.nlm.nih.gov/40712010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,39801921,Whole-Genome Methylation Sequencing Analysis and Functional Verification of LIM-Homeobox Family Genes in Cervical Cancer.,2025,10.2147/ijgm.s451841,https://pubmed.ncbi.nlm.nih.gov/39801921/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,40115255,Targeting glycolysis in esophageal squamous cell carcinoma: single-cell and multi-omics insights for risk stratification and personalized therapy.,2025,10.3389/fphar.2025.1559546,https://pubmed.ncbi.nlm.nih.gov/40115255/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,37980488,"Transcription factor LHX9 (LIM Homeobox 9) enhances pyruvate kinase PKM2 activity to induce glycolytic metabolic reprogramming in cancer stem cells, promoting gastric cancer progression.",2023,10.1186/s12967-023-04658-7,https://pubmed.ncbi.nlm.nih.gov/37980488/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,40102860,FOXL2 drives the differentiation of supporting gonadal cells in early ovarian development.,2025,10.1186/s12958-025-01377-0,https://pubmed.ncbi.nlm.nih.gov/40102860/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,38438260,Excitatory Spinal Lhx9-Derived Interneurons Modulate Locomotor Frequency in Mice.,2024,10.1523/jneurosci.1607-23.2024,https://pubmed.ncbi.nlm.nih.gov/38438260/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,38902711,Genetically evaluating the causal role of peripheral immune cells in colorectal cancer: a two-sample Mendelian randomization study.,2024,10.1186/s12885-024-12515-z,https://pubmed.ncbi.nlm.nih.gov/38902711/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,34536269,"LHX9, a p53-binding protein, inhibits the progression of glioma by suppressing glycolysis.",2021,10.18632/aging.203436,https://pubmed.ncbi.nlm.nih.gov/34536269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,37084273,RNA sequencing and expression analysis reveal a role for Lhx9 in the haploinsufficient adult mouse ovary.,2023,10.1002/mrd.23686,https://pubmed.ncbi.nlm.nih.gov/37084273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,38867378,Spatiotemporal cell landscape of human embryonic tooth development.,2024,10.1111/cpr.13653,https://pubmed.ncbi.nlm.nih.gov/38867378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,35594452,Loss of Raptor induces Sertoli cells into an undifferentiated state in mice.,2022,10.1093/biolre/ioac104,https://pubmed.ncbi.nlm.nih.gov/35594452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,33579692,LIM Homeobox 9 knockdown by morpholino does not affect zebrafish retinal development.,2021,10.1242/bio.056382,https://pubmed.ncbi.nlm.nih.gov/33579692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,39022590,Evo-devo applied to sleep research: an approach whose time has come.,2024,10.1093/sleepadvances/zpae040,https://pubmed.ncbi.nlm.nih.gov/39022590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,35669193,Single-Cell Transcriptomics-Based Study of Transcriptional Regulatory Features in the Non-Obstructive Azoospermia Testis.,2022,10.3389/fgene.2022.875762,https://pubmed.ncbi.nlm.nih.gov/35669193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,34620221,Diagnosis of pulmonary nodules by DNA methylation analysis in bronchoalveolar lavage fluids.,2021,10.1186/s13148-021-01163-w,https://pubmed.ncbi.nlm.nih.gov/34620221/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,34065391,Characterization of Alternative Splicing (AS) Events during Chicken (Gallus gallus) Male Germ-Line Stem Cell Differentiation with Single-Cell RNA-seq.,2021,10.3390/ani11051469,https://pubmed.ncbi.nlm.nih.gov/34065391/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,25725064,Evolutionarily conserved regulation of hypocretin neuron specification by Lhx9.,2015,10.1242/dev.117424,https://pubmed.ncbi.nlm.nih.gov/25725064/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,30212560,Newborn blood DNA epigenetic variations and signaling pathway genes associated with Tetralogy of Fallot (TOF).,2018,10.1371/journal.pone.0203893,https://pubmed.ncbi.nlm.nih.gov/30212560/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,31451602,Homeoprotein Neuroprotection of Embryonic Neuronal Cells.,2019,10.1523/eneuro.0061-19.2019,https://pubmed.ncbi.nlm.nih.gov/31451602/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,29405116,"Developmental evolution of the forebrain in cavefish, from natural variations in neuropeptides to behavior.",2018,10.7554/elife.32808,https://pubmed.ncbi.nlm.nih.gov/29405116/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,23431030,Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation.,2013,10.1101/gad.207654.112,https://pubmed.ncbi.nlm.nih.gov/23431030/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,25931513,Key Role of Amino Acid Repeat Expansions in the Functional Diversification of Duplicated Transcription Factors.,2015,10.1093/molbev/msv103,https://pubmed.ncbi.nlm.nih.gov/25931513/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,19530241,DNA hypermethylation accompanied by transcriptional repression in follicular lymphoma.,2009,10.1002/gcc.20687,https://pubmed.ncbi.nlm.nih.gov/19530241/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,21637844,Directed neural differentiation of mouse embryonic stem cells is a sensitive system for the identification of novel Hox gene effectors.,2011,10.1371/journal.pone.0020197,https://pubmed.ncbi.nlm.nih.gov/21637844/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LHX9,ENSG00000143355,Unsafe,17595868,[Morphogenesis and differentiation of the female genital tract. Genetic determinism and epithelium-stromal interactions].,2007,,https://pubmed.ncbi.nlm.nih.gov/17595868/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIAT1,ENSG00000187624,Unsafe,39081859,tRNA Arg binds in vitro TDP-43 RNA recognition motifs and ligand of Ate1 protein LIAT1.,2024,10.17912/micropub.biology.001224,https://pubmed.ncbi.nlm.nih.gov/39081859/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIAT1,ENSG00000187624,Unsafe,33443146,The Ligand of Ate1 is intrinsically disordered and participates in nucleolar phase separation regulated by Jumonji Domain Containing 6.,2021,10.1073/pnas.2015887118,https://pubmed.ncbi.nlm.nih.gov/33443146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIAT1,ENSG00000187624,Unsafe,25369936,"Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats.",2014,10.1073/pnas.1419587111,https://pubmed.ncbi.nlm.nih.gov/25369936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIAT1,ENSG00000187624,Unsafe,28865488,Distinct transcriptional and metabolic profiles associated with empathy in Buddhist priests: a pilot study.,2017,10.1186/s40246-017-0117-3,https://pubmed.ncbi.nlm.nih.gov/28865488/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,42343416,Non-syndromic premature ovarian insufficiency associated with monoallelic LIG4 mutation via haploinsufficiency.,2026,10.1186/s13048-026-02163-1,https://pubmed.ncbi.nlm.nih.gov/42343416/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,42523098,Ultrasound-triggered platelet vehicles loading fluorescein for targeted sonodynamic therapy of glioblastoma.,2026,10.1080/10717544.2026.2708389,https://pubmed.ncbi.nlm.nih.gov/42523098/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,42678744,Hypomorphic Lig4 gene mutation in mice predisposes to Th1-skewed intestinal inflammation.,2026,10.1172/jci.insight.199040,https://pubmed.ncbi.nlm.nih.gov/42678744/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,42510787,Identification and Preliminary Clinical Assessment of Key Genes Related to Endoplasmic Reticulum Stress and Autophagy in Minimal Change Disease.,2026,10.3390/genes17070747,https://pubmed.ncbi.nlm.nih.gov/42510787/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,40913103,Transcriptional regulation of Ligase IV by an intronic regulatory element directs thymocyte development.,2025,10.1038/s41435-025-00353-3,https://pubmed.ncbi.nlm.nih.gov/40913103/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,42650110,LIG4 Syndrome Presenting with Extensive Cutaneous Viral Warts Caused by Multi-Type HPV Infection.,2026,10.3390/genes17080917,https://pubmed.ncbi.nlm.nih.gov/42650110/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,39673806,Lig3-dependent rescue of mouse viability and DNA double-strand break repair by catalytically inactive Lig4.,2025,10.1093/nar/gkae1216,https://pubmed.ncbi.nlm.nih.gov/39673806/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,41811450,BRCA1-A and LIG4 complexes mediate ecDNA biogenesis and cancer drug resistance.,2026,10.1073/pnas.2530443123,https://pubmed.ncbi.nlm.nih.gov/41811450/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,41813791,Deciphering novel genotypic biomarkers and functional alterations in double strand break repair pathways for Parkinson's disease.,2026,10.1038/s41598-026-43533-5,https://pubmed.ncbi.nlm.nih.gov/41813791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,41843683,Phosphorylation and DNA damage resolution coordinate SOX2-mediated reprogramming in vivo.,2026,10.1073/pnas.2519117123,https://pubmed.ncbi.nlm.nih.gov/41843683/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,41147058,Knockout of Ligase4 gene enhances homology-directed repair efficiency in Plutella xylostella.,2025,10.1111/1744-7917.70184,https://pubmed.ncbi.nlm.nih.gov/41147058/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,41462961,Lactate Enhances Non-Homologous End Joining Repair and Chemoresistance Through Facilitating XRCC4-LIG4 Complex Assembly in Ovarian Cancer.,2025,10.3390/biomedicines13122949,https://pubmed.ncbi.nlm.nih.gov/41462961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,40448271,Manipulating alternative end-joining alters carbon-ion beam-induced genome mutation profiles in Arabidopsis thaliana.,2025,10.1093/dnares/dsaf014,https://pubmed.ncbi.nlm.nih.gov/40448271/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,39698004,A Chinese Girl With LIG4 Syndrome and Hematopoietic Stem Cell Transplantation: A Rare Case Report and Review of the Literature.,2024,10.1002/ccr3.70007,https://pubmed.ncbi.nlm.nih.gov/39698004/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,40744919,PIPKIγ promotes non-homologous end joining through LIG4 to enhance radiotherapy resistance in triple-negative breast cancer.,2025,10.1038/s41419-025-07894-5,https://pubmed.ncbi.nlm.nih.gov/40744919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,40037856,DNA Ligase 4 Inhibition Sensitizes Prostate Cancer to Immune Checkpoint Blockade &lt;i&gt;In Vivo&lt;/i&gt;.,2025,10.21873/anticanres.17476,https://pubmed.ncbi.nlm.nih.gov/40037856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,38351293,Expanding the phenotypic spectrum of LIG4 pathogenic variations: neuro-histopathological description of 4 fetuses with stenosis of the aqueduct.,2024,10.1038/s41431-024-01558-2,https://pubmed.ncbi.nlm.nih.gov/38351293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,42861852,Genome-wide mapping of Cas9-induced sister chromatid exchange across single and over 200 genomic sites in human cells.,2026,10.7554/elife.112073,https://pubmed.ncbi.nlm.nih.gov/42861852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,39375425,Negative feedback loop in the activation of non-homologous end joining DNA repair pathway in Helicobacter pylori infected patients with gastritis.,2024,10.1038/s41598-024-74138-5,https://pubmed.ncbi.nlm.nih.gov/39375425/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,42209588,"Clinical and genetic landscape of SCID in Yunnan, China: identification of two novel RAG2 variants.",2026,10.1038/s41598-026-54172-1,https://pubmed.ncbi.nlm.nih.gov/42209588/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,41902554,An Update on Inborn Errors of V(D)J Recombination.,2026,10.1152/physiol.00004.2026,https://pubmed.ncbi.nlm.nih.gov/41902554/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,42707602,Integrated expression profiling of BCR-ABL and computational identification of ABL1 inhibitors in pediatric acute lymphoblastic leukemia.,2026,10.1007/s40203-026-00731-3,https://pubmed.ncbi.nlm.nih.gov/42707602/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,41705238,Clinical and genetic spectrum of inborn errors of immunity: a retrospective study on outcomes at a single center.,2026,10.3389/fimmu.2026.1758410,https://pubmed.ncbi.nlm.nih.gov/41705238/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,36221079,DNA ligase IV dificiency with elevated serum IgG levels suspected to have myelodysplastic syndrome: a case report.,2022,10.1186/s12887-022-03655-x,https://pubmed.ncbi.nlm.nih.gov/36221079/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,37004747,Autoimmunity and immunodeficiency associated with monoallelic LIG4 mutations via haploinsufficiency.,2023,10.1016/j.jaci.2023.03.022,https://pubmed.ncbi.nlm.nih.gov/37004747/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,40457861,Centralized rapid genetic diagnosis of combined immunodeficiency in Japan.,2025,10.1111/ped.70085,https://pubmed.ncbi.nlm.nih.gov/40457861/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,39060055,"Identification of DNA Repair-related Genes as Biomarkers Reflecting MSI, TMB, and TIL in Colorectal Cancer.",2024,10.21873/anticanres.17179,https://pubmed.ncbi.nlm.nih.gov/39060055/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,32778095,Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.,2020,10.1186/s12885-020-07253-x,https://pubmed.ncbi.nlm.nih.gov/32778095/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,40633676,Tumor-derived CD84 promotes growth of acute myeloid leukemia cells via regulating nonhomologous DNA end-joining pathway.,2025,10.1016/j.mocell.2025.100253,https://pubmed.ncbi.nlm.nih.gov/40633676/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIG4,ENSG00000174405,Unsafe,7760816,"Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination.",1995,10.1128/mcb.15.6.3206,https://pubmed.ncbi.nlm.nih.gov/7760816/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,41975528,LIN28A‒let-7b axis drives the aggressive and proinflammatory phenotype of rheumatoid arthritis fibroblast-like synoviocytes.,2026,10.1186/s13075-026-03809-7,https://pubmed.ncbi.nlm.nih.gov/41975528/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,42445842,Lin28 Represses Hub Cell microRNAs to Maintain &lt;i&gt;Drosophila&lt;/i&gt; Testis Niche Function.,2026,10.12717/dr.2026.30.2.105,https://pubmed.ncbi.nlm.nih.gov/42445842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,42550806,let-7 miRNA and lin-46 mRNA are essential targets of the LIN28 RNA-binding protein in Caenorhabditis elegans developmental timing regulation.,2026,10.1371/journal.pbio.3003892,https://pubmed.ncbi.nlm.nih.gov/42550806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,42656197,Temporal dynamics of intragenic enhancer RNAs regulate Lin28a expression in response to external stimuli in embryonic stem cells.,2026,10.1093/nar/gkag837,https://pubmed.ncbi.nlm.nih.gov/42656197/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,41521656,Mechanistic insights into Lin28-dependent oligo-uridylylation of pre-let-7 by TUT4.,2026,10.1093/nar/gkaf1421,https://pubmed.ncbi.nlm.nih.gov/41521656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,41019289,LIN28-mediated gene regulatory loops synchronize transitions throughout organogenesis.,2025,10.1016/j.bbrep.2025.102226,https://pubmed.ncbi.nlm.nih.gov/41019289/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,42839614,Modulation of Presynaptic Inhibitory Retinal Circuits for Retinal Ganglion Cell Neuroprotection in Glaucoma.,2026,10.1002/advs.78179,https://pubmed.ncbi.nlm.nih.gov/42839614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,41793240,LIN28A blocks the EndMT process of high glucose-induced HRMECs by stabilizing SIRT6 mRNA.,2026,10.1111/jdi.70284,https://pubmed.ncbi.nlm.nih.gov/41793240/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,42208531,ZFHX4 is necessary for dopaminergic neuron differentiation and controls cell cycle by regulating LIN28A.,2026,10.1016/j.stemcr.2026.102930,https://pubmed.ncbi.nlm.nih.gov/42208531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,42886803,Peripheral nerve injury alters metabolic function and neuronal excitability through the Lin28/let-7 pathway.,2026,10.1126/sciadv.aeh6791,https://pubmed.ncbi.nlm.nih.gov/42886803/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,42666440,"Stem cell regulation: conserved pluripotency, transcriptional, and metabolic networks in animals and plants.",2026,10.3389/fcell.2026.1779433,https://pubmed.ncbi.nlm.nih.gov/42666440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,41981464,The transcription factor E4F1 is crucial for spermatogonial differentiation and meiosis progression in mice.,2026,10.1186/s12864-026-12649-3,https://pubmed.ncbi.nlm.nih.gov/41981464/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,39292784,Development of miRNA-based PROTACs targeting Lin28 for breast cancer therapy.,2024,10.1126/sciadv.adp0334,https://pubmed.ncbi.nlm.nih.gov/39292784/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,42519000,The expression of Lin28a in the ovaries and the association of &lt;i&gt;Lin28a&lt;/i&gt; and &lt;i&gt;Lin28b&lt;/i&gt; with litter size in goats.,2025,10.5194/aab-68-435-2025,https://pubmed.ncbi.nlm.nih.gov/42519000/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,41664204,Clinicopathological and prognostic insights into Embryonal Tumors with Multilayered Rosettes (ETMRs).,2026,10.1186/s13000-026-01766-y,https://pubmed.ncbi.nlm.nih.gov/41664204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,40624922,Prognostic significance of Lin28A protein expression in papillary thyroid carcinoma.,2025,10.4103/ijpm.ijpm_358_24,https://pubmed.ncbi.nlm.nih.gov/40624922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,42217413,RBM46 promotes meiotic initiation during oogenesis.,2026,10.1016/j.bbrc.2026.154058,https://pubmed.ncbi.nlm.nih.gov/42217413/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,42033539,The DNA Demethylase TET1 is a Pivotal Regulator of the miR-124/ISX9-Instructed Conversion of Astrocytes to Induced Neurons.,2026,10.1007/s12035-026-05873-1,https://pubmed.ncbi.nlm.nih.gov/42033539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,40680886,Spatial Proteomics Reveals Distinct Protein Patterns in Cortical Migration Disorders Caused by LIN28A Overexpression and WNT Activation.,2025,10.1016/j.mcpro.2025.101037,https://pubmed.ncbi.nlm.nih.gov/40680886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,41527427,LCZ696 (sacubitril/valsartan mixture) promotes cardiac repair and reverses residual remodelling of surgical ventricular reconstruction in post-myocardial infarction mice by targeting circMap4k2/LIN28A/PDK1 pathway.,2026,10.1111/bph.70320,https://pubmed.ncbi.nlm.nih.gov/41527427/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,39478867,LIN28 upregulation in primary human T cells impaired CAR T antitumoral activity.,2024,10.3389/fimmu.2024.1462796,https://pubmed.ncbi.nlm.nih.gov/39478867/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,42519790,"Locus-specific HERV expression identifies an aggressive, NK-depleted, checkpoint-refractory acral melanoma phenotype.",2026,10.3389/fmed.2026.1834744,https://pubmed.ncbi.nlm.nih.gov/42519790/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,41565205,LIN28A-Dependent Kinome and Phosphoproteome Reprogramming Promotes Imatinib Resistance.,2026,10.1016/j.mcpro.2026.101514,https://pubmed.ncbi.nlm.nih.gov/41565205/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,39152528,The role of Lin28A and Lin28B in cancer beyond Let-7.,2024,10.1002/1873-3468.15004,https://pubmed.ncbi.nlm.nih.gov/39152528/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,40526838,STAT1-mediated epigenetic regulation of LIN28A controls iPSC-derived platelet production through the let-7-RALB axis.,2025,10.1182/bloodadvances.2024015557,https://pubmed.ncbi.nlm.nih.gov/40526838/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,41770250,Erzhi pills: a potential aging-modulating agent targeting immunosenescence in mice.,2026,10.1007/s10522-026-10387-3,https://pubmed.ncbi.nlm.nih.gov/41770250/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,37868985,Lin28 regulates thymic growth and involution and correlates with MHCII expression in thymic epithelial cells.,2023,10.3389/fimmu.2023.1261081,https://pubmed.ncbi.nlm.nih.gov/37868985/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,40102931,Enhancing myelinogenesis through LIN28A rescues impaired cognition in PWMI mice.,2025,10.1186/s13287-025-04267-9,https://pubmed.ncbi.nlm.nih.gov/40102931/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,40788992,PCSK9 Loss-of-Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects.,2025,10.1002/advs.202504291,https://pubmed.ncbi.nlm.nih.gov/40788992/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,41430335,"YAP1::MAML2 fusion, a newly identified genetic anomaly in a posterior fossa infant tumor, associated with the methylation class ""embryonal tumor with multilayered rosettes, non-C19MC-altered"" in the Heidelberg central nervous system tumor classifier and ""embryonal tumor with multilayered rosettes-DICER"" in the NIH classifier.",2025,10.1186/s40478-025-02165-y,https://pubmed.ncbi.nlm.nih.gov/41430335/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,38135347,Identification of pan-cancer/testis genes and validation of therapeutic targeting in triple-negative breast cancer: Lin28a-based and Siglece-based vaccination induces antitumor immunity and inhibits metastasis.,2023,10.1136/jitc-2023-007935,https://pubmed.ncbi.nlm.nih.gov/38135347/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,38784453,Live cell screening to identify RNA-binding small molecule inhibitors of the pre-let-7-Lin28 RNA-protein interaction.,2024,10.1039/d4md00123k,https://pubmed.ncbi.nlm.nih.gov/38784453/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,39800739,Developing novel Lin28 inhibitors by computer aided drug design.,2025,10.1038/s41420-024-02281-z,https://pubmed.ncbi.nlm.nih.gov/39800739/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,42328431,"Role of WDR66 in Stemness, Therapy Resistance and Tumor microenvironment modulation in Head and Neck Cancer.",2026,10.7150/ijbs.130010,https://pubmed.ncbi.nlm.nih.gov/42328431/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,42293764,Unraveling Let-7f in oncology: a tumor suppressor with emerging clinical significance.,2026,10.3389/fcell.2026.1825514,https://pubmed.ncbi.nlm.nih.gov/42293764/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,41802683,Lycorine suppresses cell growth and attenuates stemness through PI3K/AKT pathway in ovarian cancer.,2026,10.1016/j.bcp.2026.117876,https://pubmed.ncbi.nlm.nih.gov/41802683/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,40639260,Generation of chicken induced pluripotent stem cells (iPSCs) from somatic cells using multi-lentiviral transduction and OAC2.,2025,10.1016/j.theriogenology.2025.117567,https://pubmed.ncbi.nlm.nih.gov/40639260/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,22118463,Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.,2011,10.1016/j.cell.2011.10.039,https://pubmed.ncbi.nlm.nih.gov/22118463/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,15722555,Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation.,2005,10.1074/jbc.m412247200,https://pubmed.ncbi.nlm.nih.gov/15722555/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,15614775,Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells.,2005,10.1002/dvdy.20247,https://pubmed.ncbi.nlm.nih.gov/15614775/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28A,ENSG00000131914,Unsafe,14688391,The transcriptome profile of human embryonic stem cells as defined by SAGE.,2004,10.1634/stemcells.22-1-51,https://pubmed.ncbi.nlm.nih.gov/14688391/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,42800024,Protocol to prepare PARPi-combined LIN28B siRNA nanoparticles and evaluate therapeutic efficacy of malignant ascites.,2026,10.1016/j.xpro.2026.104854,https://pubmed.ncbi.nlm.nih.gov/42800024/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,40310608,LIN 28B expression is downregulated in mature spermatozoa of oligozoospermic men and associates with genetic variants previously linked to pubertal onset.,2025,10.1530/ec-25-0044,https://pubmed.ncbi.nlm.nih.gov/40310608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,42213620,LIN28B is essential for human fetal B-lymphopoiesis and initiation of KMT2A::AFF1 infant leukemia.,2026,10.1182/blood.2025028877,https://pubmed.ncbi.nlm.nih.gov/42213620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,41905330,Comparative effectiveness of 7 major human let-7-5p isoforms to modulate target gene expression in liver cells.,2026,10.1016/j.dmd.2026.100260,https://pubmed.ncbi.nlm.nih.gov/41905330/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,42861489,Pentagalloylglucose induces ferroptosis-related cell death by disrupting lipid homeostasis through the let-7a-5p/LIN28B/SREBP1 axis in colorectal cancer.,2026,10.1039/d6fo02997c,https://pubmed.ncbi.nlm.nih.gov/42861489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,42693143,CAFs shape the immunosuppressive microenvironment of pancreatic cancer through the Lin28b-STING Axis.,2026,10.1038/s41467-026-76495-3,https://pubmed.ncbi.nlm.nih.gov/42693143/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,41817622,Proteomic analysis reveals the pro-proliferative role of the LIN28B/HMGA2 axis in hepatoblastoma.,2026,10.1007/s00383-026-06385-8,https://pubmed.ncbi.nlm.nih.gov/41817622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,41388151,NRAV promotes HCC stemness via the m6A-regulated let-7c-5p/LIN28B axis.,2026,10.1038/s41417-025-00995-5,https://pubmed.ncbi.nlm.nih.gov/41388151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,41674542,LIN28B Aggravates the Inflammation in Sepsis-Induced Lung Injury by Stabilizing GATA6 mRNA and Upregulating TRAF6.,2026,10.1002/pul2.70259,https://pubmed.ncbi.nlm.nih.gov/41674542/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,40265419,Role of LIN28B in the Regulation of Ribosomal Biogenesis and Lipid Metabolism in Medulloblastoma Brain Cancer Cells.,2025,10.3390/proteomes13020014,https://pubmed.ncbi.nlm.nih.gov/40265419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,41389200,Ribosomal protein control of hematopoietic stem cell transformation through regulation of metabolism.,2025,10.1016/j.celrep.2025.116688,https://pubmed.ncbi.nlm.nih.gov/41389200/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,41572432,PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites.,2026,10.1002/advs.202510547,https://pubmed.ncbi.nlm.nih.gov/41572432/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,40740861,LIN28B promotes the progression of endometrial cancer through upregulating MYC and correlates with immune microenvironment.,2025,10.3389/fonc.2025.1592193,https://pubmed.ncbi.nlm.nih.gov/40740861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,41298451,Microprotein PLUM encoded by Lin28b uORF is a cytoplasmic determinant of pluripotency and embryonic development.,2025,10.1038/s41467-025-66297-4,https://pubmed.ncbi.nlm.nih.gov/41298451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,41604465,A first-in-class small-molecule inhibitor targeting AVIL exhibits safety and antitumor efficacy in preclinical models of glioblastoma.,2026,10.1126/scitranslmed.adt1211,https://pubmed.ncbi.nlm.nih.gov/41604465/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,41427137,miR-379-5p retards the proliferation and differentiation of goat skeletal muscle satellite cells by targeting &lt;i&gt;LIN28B&lt;/i&gt;.,2025,10.3389/fvets.2025.1694160,https://pubmed.ncbi.nlm.nih.gov/41427137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,41805027,First-in-Class Small Molecule Inhibitor of Oncogene &lt;i&gt;AVIL&lt;/i&gt; in Glioblastoma.,2026,10.1177/10445498261431994,https://pubmed.ncbi.nlm.nih.gov/41805027/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,41406550,Target validation and drug discovery for TNBC: Targeting the Lin28B/Let-7/PBK with the ponicidin.,2026,10.1016/j.ejmech.2025.118474,https://pubmed.ncbi.nlm.nih.gov/41406550/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,40800176,&lt;i&gt;LIN28B&lt;/i&gt; hypomethylation drives oncogenic signaling and stratifies poor prognosis in juvenile myelomonocytic leukemia.,2025,10.21037/tp-2025-228,https://pubmed.ncbi.nlm.nih.gov/40800176/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,40419509,HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity.,2025,10.1038/s41467-025-60129-1,https://pubmed.ncbi.nlm.nih.gov/40419509/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,42358008,Incorporation of multiple diversity genes in the TCRδ chain is highly regulated and evolutionarily conserved.,2026,10.1093/jimmun/vkag137,https://pubmed.ncbi.nlm.nih.gov/42358008/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,41930179,Multi-Scale Transcriptomic Sequencing Data Analysis Reveals &lt;i&gt;LINC00467&lt;/i&gt; is Associated with Malignant Progression in Breast Cancer: An &lt;i&gt;In Silico&lt;/i&gt; and &lt;i&gt;In Vitro&lt;/i&gt; Study.,2026,10.32604/or.2026.067601,https://pubmed.ncbi.nlm.nih.gov/41930179/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,39808497,LIN28B-mediated PI3K/AKT pathway activation promotes metastasis in colorectal cancer models.,2025,10.1172/jci186035,https://pubmed.ncbi.nlm.nih.gov/39808497/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,41309865,Uncovering the role of RNA binding proteins in colorectal cancer through single-cell transcriptomic analysis.,2025,10.1038/s41598-025-29678-9,https://pubmed.ncbi.nlm.nih.gov/41309865/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,40143971,Regulation of HSC development and function by Lin28b.,2025,10.3389/fcell.2025.1555877,https://pubmed.ncbi.nlm.nih.gov/40143971/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,39668567,PHAX enhanced LIN28B-mediated PBX3 mRNA stability to promote esophageal cancer development.,2025,10.1111/cas.16420,https://pubmed.ncbi.nlm.nih.gov/39668567/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,36609146,Targeting Lin28 axis enhances glypican-3-CAR T cell efficacy against hepatic tumor initiating cell population.,2023,10.1016/j.ymthe.2023.01.002,https://pubmed.ncbi.nlm.nih.gov/36609146/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,42499246,SARS-CoV-2 and Cancer Biology: Exploring the Mechanistic Links.,2026,10.1002/cnr2.70629,https://pubmed.ncbi.nlm.nih.gov/42499246/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,40746360,A Study to Evaluate the Potential Role and Clinical Application Value of Long Noncoding RNA CASC Family Members in Colorectal Cancer Based on Transcriptomic Data.,2025,10.1155/ijog/3881424,https://pubmed.ncbi.nlm.nih.gov/40746360/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,39152528,The role of Lin28A and Lin28B in cancer beyond Let-7.,2024,10.1002/1873-3468.15004,https://pubmed.ncbi.nlm.nih.gov/39152528/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,22118463,Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.,2011,10.1016/j.cell.2011.10.039,https://pubmed.ncbi.nlm.nih.gov/22118463/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN28B,ENSG00000187772,Unsafe,16971064,Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma.,2006,10.1016/j.gene.2006.07.011,https://pubmed.ncbi.nlm.nih.gov/16971064/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,40021783,Impact of LIN7A silencing on U87 cell invasion and its clinical significance in glioblastoma.,2025,10.1038/s41598-025-91285-5,https://pubmed.ncbi.nlm.nih.gov/40021783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,41506484,Single-cell analysis identifies BASP1 as a driver of drug resistance and cell plasticity in oral squamous cell carcinoma.,2026,10.1016/j.jbc.2025.111126,https://pubmed.ncbi.nlm.nih.gov/41506484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,38957040,Identification and validation of miR-29b-3p and LIN7A as important diagnostic markers for bone non-union by WGCNA.,2024,10.1111/jcmm.18522,https://pubmed.ncbi.nlm.nih.gov/38957040/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,39062857,Inhibiting miR-618 Promotes Keratinocytes Proliferation and Migration to Enhance Wound Healing in Mice.,2024,10.3390/ijms25147617,https://pubmed.ncbi.nlm.nih.gov/39062857/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,38496843,Identification of diagnostic biomarkers for osteoarthritis through bioinformatics and machine learning.,2024,10.1016/j.heliyon.2024.e27506,https://pubmed.ncbi.nlm.nih.gov/38496843/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,38566986,Transcriptomics in idiopathic pulmonary fibrosis unveiled: a new perspective from differentially expressed genes to therapeutic targets.,2024,10.3389/fimmu.2024.1375171,https://pubmed.ncbi.nlm.nih.gov/38566986/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,37273699,Comprehensive analysis of a pyroptosis-related gene signature of clinical and biological values in spinal cord injury.,2023,10.3389/fneur.2023.1141939,https://pubmed.ncbi.nlm.nih.gov/37273699/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,36864492,DNA methylation landscape reveals LIN7A as a decitabine-responsive marker in patients with t(8;21) acute myeloid leukemia.,2023,10.1186/s13148-023-01458-0,https://pubmed.ncbi.nlm.nih.gov/36864492/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,33726762,"The loss of DLG2 isoform 7/8, but not isoform 2, is critical in advanced staged neuroblastoma.",2021,10.1186/s12935-021-01851-w,https://pubmed.ncbi.nlm.nih.gov/33726762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,35962298,Differential Gene Expression in Sporadic and Genetic Forms of Alzheimer's Disease and Frontotemporal Dementia in Brain Tissue and Lymphoblastoid Cell Lines.,2022,10.1007/s12035-022-02969-2,https://pubmed.ncbi.nlm.nih.gov/35962298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,38082497,Identifying genes for regulating osteogenic differentiation of human periodontal ligament stem cells in inflammatory environments by bioinformatics analysis.,2024,10.1111/jre.13215,https://pubmed.ncbi.nlm.nih.gov/38082497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,36185374,Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration.,2022,10.1016/j.isci.2022.105050,https://pubmed.ncbi.nlm.nih.gov/36185374/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,33526581,Golgi localization of the LIN-2/7/10 complex points to a role in basolateral secretion of LET-23 EGFR in the Caenorhabditiselegans vulval precursor cells.,2021,10.1242/dev.194167,https://pubmed.ncbi.nlm.nih.gov/33526581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,37207785,Genetic analysis of cuproptosis subtypes and immunological features in severe influenza.,2023,10.1016/j.micpath.2023.106162,https://pubmed.ncbi.nlm.nih.gov/37207785/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,30408049,Transcriptome profiling of transgenic potato plants provides insights into variability caused by plant transformation.,2018,10.1371/journal.pone.0206055,https://pubmed.ncbi.nlm.nih.gov/30408049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,37036419,Molecular Pathology of Micropapillary Carcinomas: Is Characteristic Morphology Related to Molecular Mechanisms?,2023,10.1097/pai.0000000000001123,https://pubmed.ncbi.nlm.nih.gov/37036419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,30537154,Long noncoding RNA CASC9 promotes LIN7A expression via miR-758-3p to facilitate the malignancy of ovarian cancer.,2019,10.1002/jcp.27903,https://pubmed.ncbi.nlm.nih.gov/30537154/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,31137733,Identification of Crucial Candidate Genes and Pathways in Glioblastoma Multiform by Bioinformatics Analysis.,2019,10.3390/biom9050201,https://pubmed.ncbi.nlm.nih.gov/31137733/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,29749382,microRNA-501-3p suppresses metastasis and progression of hepatocellular carcinoma through targeting LIN7A.,2018,10.1038/s41419-018-0577-y,https://pubmed.ncbi.nlm.nih.gov/29749382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,26887652,LIN7A is a major determinant of cell-polarity defects in breast carcinomas.,2016,10.1186/s13058-016-0680-x,https://pubmed.ncbi.nlm.nih.gov/26887652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,30890323,Extenuation of in utero toxic effects of MeHg in the developing neurons by Fisetin via modulating the expression of synaptic transmission and plasticity regulators in hippocampus of the rat offspring.,2019,10.1016/j.cbi.2019.03.014,https://pubmed.ncbi.nlm.nih.gov/30890323/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,20720508,Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease.,2010,10.1097/nen.0b013e3181ed7a41,https://pubmed.ncbi.nlm.nih.gov/20720508/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIN7A,ENSG00000111052,Unsafe,11311936,VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain.,2001,10.1016/s0167-4781(01)00191-9,https://pubmed.ncbi.nlm.nih.gov/11311936/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,41620535,Identification of RBX1 as a regulator of LIPT1 transcription and its role in copper-induced cell death in GBM cells.,2026,10.1038/s41598-026-37105-w,https://pubmed.ncbi.nlm.nih.gov/41620535/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,41511816,Effect of EGR1/LIPT1 regulatory axis on cuproptosis in chromophobe renal cell carcinoma.,2026,10.1093/bfgp/elaf023,https://pubmed.ncbi.nlm.nih.gov/41511816/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,41337580,Targeting multiple genetic defects of mitochondrial diseases with a single bacterial lipoate protein ligase.,2025,10.1126/sciadv.aea8481,https://pubmed.ncbi.nlm.nih.gov/41337580/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,42066089,LIPT1 loss confers replication stress and PARP inhibitor sensitivity through PrimPol-mediated ssDNA gaps.,2026,10.1126/sciadv.aed8013,https://pubmed.ncbi.nlm.nih.gov/42066089/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,42889184,LncRNA AP003469.2 promotes hepatocellular carcinoma progression by regulating cuproptosis via the miR-4732-3p/LIPT1 axis.,2026,10.3389/fonc.2026.1874176,https://pubmed.ncbi.nlm.nih.gov/42889184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,42471718,"Copper homeostasis and cuproptosis rewire the tumor microenvironment: mechanisms, immune modulation, and therapeutic opportunities.",2026,10.1186/s13045-026-01831-5,https://pubmed.ncbi.nlm.nih.gov/42471718/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,42433268,Integrative analysis of cuproptosis in kidney ischemia-reperfusion injury: biomarker discovery and diagnostic model construction.,2026,10.3389/fmolb.2026.1740289,https://pubmed.ncbi.nlm.nih.gov/42433268/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,42445351,Cuproptosis: A Potential Target for the Treatment of Systemic Lupus Erythematosus.,2026,10.2147/jir.s605979,https://pubmed.ncbi.nlm.nih.gov/42445351/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,42383521,Analysis of end-stage renal disease mediated by cuproptosis-related genes.,2026,10.5414/cn111966,https://pubmed.ncbi.nlm.nih.gov/42383521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,40367233,"Comprehensive analysis and experiment validation of five cuproptosis-related genes in prognosis, immune infiltration and metabolic characterization of pancreatic cancer.",2025,10.1371/journal.pone.0323458,https://pubmed.ncbi.nlm.nih.gov/40367233/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,42506898,ATP7A Orchestrates Tumor Progression and Cuproptosis in Hepatocellular Carcinoma via the LINC02038-miR-506-3p Regulatory Circuit.,2026,10.1002/jbt.71027,https://pubmed.ncbi.nlm.nih.gov/42506898/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,42418063,Copper homeostasis and cuproptosis: molecular mechanisms and therapeutic opportunities.,2026,10.1186/s43556-026-00491-8,https://pubmed.ncbi.nlm.nih.gov/42418063/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,39652607,Identification of cuproptosis-related genes in septic shock based on bioinformatic analysis.,2024,10.1371/journal.pone.0315219,https://pubmed.ncbi.nlm.nih.gov/39652607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,38041690,Cuproptosis-related gene LIPT1 as a prognostic indicator in non-small cell lung cancer: Functional involvement and regulation of ATOX1 expression.,2024,10.17305/bb.2023.9931,https://pubmed.ncbi.nlm.nih.gov/38041690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,40073141,Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair.,2025,10.1126/sciadv.adt1241,https://pubmed.ncbi.nlm.nih.gov/40073141/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,39199267,A Multi-Target Pharmacological Correction of a Lipoyltransferase LIPT1 Gene Mutation in Patient-Derived Cellular Models.,2024,10.3390/antiox13081023,https://pubmed.ncbi.nlm.nih.gov/39199267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,40253387,Endoplasmic reticulum stress related super-enhancers suppress cuproptosis via glycolysis reprogramming in lung adenocarcinoma.,2025,10.1038/s41419-025-07613-0,https://pubmed.ncbi.nlm.nih.gov/40253387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,41469517,Identification and validation of prognostic markers for cuproptosis-related macrophage polarization genes in hepatocellular carcinoma.,2025,10.1007/s12672-025-04373-3,https://pubmed.ncbi.nlm.nih.gov/41469517/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,42551357,Copper homeostasis and cuproptosis: New perspectives on the diagnosis and treatment of metabolic diseases.,2026,10.1016/j.jtemb.2026.127935,https://pubmed.ncbi.nlm.nih.gov/42551357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,40560740,Clinical significance and immune microenvironment association of cuproptosis-related genes in pan-cancer.,2026,10.1113/ep092310,https://pubmed.ncbi.nlm.nih.gov/40560740/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,41170386,"Iron, copper and disulfide dysregulation: molecular crossroads of metabolic cell death in melanoma progression.",2025,10.3389/fphar.2025.1685331,https://pubmed.ncbi.nlm.nih.gov/41170386/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,39068453,"Cuproptosis, the novel type of oxidation-induced cell death in thoracic cancers: can it enhance the success of immunotherapy?",2024,10.1186/s12964-024-01743-2,https://pubmed.ncbi.nlm.nih.gov/39068453/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,39100456,The role of cuproptosis-related genes in pan-cancer and the development of cuproptosis-related risk model in colon adenocarcinoma.,2024,10.1016/j.heliyon.2024.e34011,https://pubmed.ncbi.nlm.nih.gov/39100456/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,42177195,Cuproptosis causes meiotic metaphase I arrest by disrupting mitochondrial functions in oocytes.,2026,10.1038/s41420-026-03168-x,https://pubmed.ncbi.nlm.nih.gov/42177195/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,40568577,"Multi-omics analysis untangles the crosstalk between intratumor microbiome, lactic acid metabolism and immune status in lung squamous cell carcinoma.",2025,10.3389/fimmu.2025.1603822,https://pubmed.ncbi.nlm.nih.gov/40568577/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,40355831,Copper's new role in cancer: how cuproptosis-related genes could revolutionize glioma treatment.,2025,10.1186/s12885-025-14151-7,https://pubmed.ncbi.nlm.nih.gov/40355831/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,40555995,Cuproptosis: a novel therapeutic mechanism in lung cancer.,2025,10.1186/s12935-025-03864-1,https://pubmed.ncbi.nlm.nih.gov/40555995/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,39432636,"Comprehensive analysis of the expression level, prognostic value, and immune infiltration of cuproptosis-related genes in human breast cancer.",2024,10.1097/md.0000000000040132,https://pubmed.ncbi.nlm.nih.gov/39432636/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT1,ENSG00000144182,Unsafe,10103005,"Molecular cloning, structural characterization and chromosomal localization of human lipoyltransferase gene.",1999,10.1046/j.1432-1327.1999.00204.x,https://pubmed.ncbi.nlm.nih.gov/10103005/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,41337580,Targeting multiple genetic defects of mitochondrial diseases with a single bacterial lipoate protein ligase.,2025,10.1126/sciadv.aea8481,https://pubmed.ncbi.nlm.nih.gov/41337580/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,40663606,NEDD4L induces mitochondrial dysfunction and neurodegeneration by promoting LIPT2 degradation in Huntington's disease.,2025,10.1073/pnas.2503342122,https://pubmed.ncbi.nlm.nih.gov/40663606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,38129565,Comprehensive analysis of the potential biological significance of cuproptosis-related gene LIPT2 in pan-cancer prognosis and immunotherapy.,2023,10.1038/s41598-023-50039-x,https://pubmed.ncbi.nlm.nih.gov/38129565/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,38586090,Thorough examination of the potential biological implications of the cuproptosis-related gene LIPT2 in the prognosis and immunotherapy in pan-cancer.,2024,10.62347/qnne5428,https://pubmed.ncbi.nlm.nih.gov/38586090/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,39536593,Biallelic Variants in LIPT2 as a Cause of Infantile-Onset Dystonia: Expanding the Clinical and Molecular Spectrum.,2025,10.1016/j.pediatrneurol.2024.09.013,https://pubmed.ncbi.nlm.nih.gov/39536593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,40355831,Copper's new role in cancer: how cuproptosis-related genes could revolutionize glioma treatment.,2025,10.1186/s12885-025-14151-7,https://pubmed.ncbi.nlm.nih.gov/40355831/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,39913607,Cuproptosis-related lncRNAs and genes: Potential markers for glioblastoma prognosis and treatment.,2025,10.1371/journal.pone.0315927,https://pubmed.ncbi.nlm.nih.gov/39913607/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,38248314,Comparative Transcriptome Analyses Provide New Insights into the Evolution of Divergent Thermal Resistance in Two Eel Gobies.,2023,10.3390/cimb46010012,https://pubmed.ncbi.nlm.nih.gov/38248314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,38159255,Potential impact of cuproptosis-related genes on tumor immunity in esophageal carcinoma.,2023,10.18632/aging.205391,https://pubmed.ncbi.nlm.nih.gov/38159255/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,38703760,Gut-brain bidirectional determination in regulating the residual feed intake of small-sized meat ducks.,2024,10.1016/j.psj.2024.103778,https://pubmed.ncbi.nlm.nih.gov/38703760/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,36523779,Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma.,2022,10.3389/fmed.2022.939776,https://pubmed.ncbi.nlm.nih.gov/36523779/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,38470932,KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation.,2024,10.1371/journal.ppat.1012082,https://pubmed.ncbi.nlm.nih.gov/38470932/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,37259036,The therapeutic and prognostic role of cuproptosis-related genes in triple negative breast cancer.,2023,10.1186/s12859-023-05348-3,https://pubmed.ncbi.nlm.nih.gov/37259036/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,36376617,A novel cuproptosis-related gene signature of prognosis and immune microenvironment in head and neck squamous cell carcinoma cancer.,2023,10.1007/s00432-022-04471-7,https://pubmed.ncbi.nlm.nih.gov/36376617/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,28757203,Biallelic Mutations in LIPT2 Cause a Mitochondrial Lipoylation Defect Associated with Severe Neonatal Encephalopathy.,2017,10.1016/j.ajhg.2017.07.001,https://pubmed.ncbi.nlm.nih.gov/28757203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,36213577,Cuproptosis Combined with lncRNAs Predicts the Prognosis and Immune Microenvironment of Breast Cancer.,2022,10.1155/2022/5422698,https://pubmed.ncbi.nlm.nih.gov/36213577/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,32508887,Progress in the Enzymology of the Mitochondrial Diseases of Lipoic Acid Requiring Enzymes.,2020,10.3389/fgene.2020.00510,https://pubmed.ncbi.nlm.nih.gov/32508887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,33588072,Genetic predictors of gene expression associated with psychiatric comorbidity in patients with inflammatory bowel disease - A pilot study.,2021,10.1016/j.ygeno.2021.02.001,https://pubmed.ncbi.nlm.nih.gov/33588072/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,29987032,Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes.,2018,10.1073/pnas.1805862115,https://pubmed.ncbi.nlm.nih.gov/29987032/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LIPT2,ENSG00000175536,Unsafe,28628643,Mis-targeting of the mitochondrial protein LIPT2 leads to apoptotic cell death.,2017,10.1371/journal.pone.0179591,https://pubmed.ncbi.nlm.nih.gov/28628643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,42759406,Integrative single-cell and spatial transcriptomic analyses identify LMX1B as a tumor suppressor orchestrating the GDF15-ATP4B axis in renal cell carcinoma.,2026,10.1016/j.tranon.2026.103049,https://pubmed.ncbi.nlm.nih.gov/42759406/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,42722687,Proteasome inhibition alleviates proteinuria in Lmx1b knock-in mice with dysfunctional LIM domains.,2026,10.1038/s41467-026-77485-1,https://pubmed.ncbi.nlm.nih.gov/42722687/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,41991696,An Lmx1a/b allelic series reveals the role of Lmx1 genes in cochlear nuclei development.,2026,10.1007/s00441-026-04064-7,https://pubmed.ncbi.nlm.nih.gov/41991696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,42372902,MiR-1281 downregulates LMX1B to inhibit gastric cancer development.,2026,10.1016/j.yexcr.2026.115118,https://pubmed.ncbi.nlm.nih.gov/42372902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,41776344,Non-coding genome in nail-patella syndrome: Genetic diagnosis as a guide for personalized follow-up.,2026,10.1038/s41431-026-02062-5,https://pubmed.ncbi.nlm.nih.gov/41776344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,42903334,Engrailed-1 in eccrine sweat gland development and regeneration: from evolutionary innovation to therapeutic perspectives.,2026,10.3389/fcell.2026.1917336,https://pubmed.ncbi.nlm.nih.gov/42903334/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,42541160,Transient Nephrotic Syndrome in an Infant With Heterozygous Variants of Uncertain Significance in LMX1B and TTC21B.,2026,10.7759/cureus.111908,https://pubmed.ncbi.nlm.nih.gov/42541160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,41556506,Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment.,2026,10.7554/elife.107161,https://pubmed.ncbi.nlm.nih.gov/41556506/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,42813923,Lmx1b is essential for molting and leg integrity in Henosepilachna vigintioctopunctata: Implications for RNA biopesticide development.,2026,10.1111/1744-7917.70372,https://pubmed.ncbi.nlm.nih.gov/42813923/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,42163746,Potential Protective Effect of All-trans Retinoic Acid Against Hypoxia Induced Injury in Renal Tubular Epithelial Cells.,2026,10.2174/0113816128247090251129114904,https://pubmed.ncbi.nlm.nih.gov/42163746/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,42561032,Molecular Ontology Predicts Output Connections From the Nucleus of the Solitary Tract.,2026,10.1002/cne.70188,https://pubmed.ncbi.nlm.nih.gov/42561032/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,40829147,"Characterisation of lmx1b paralogues in zebrafish reveals divergent roles in skeletal, kidney and muscle development.",2025,10.1242/bio.062038,https://pubmed.ncbi.nlm.nih.gov/40829147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,42379263,Differential vulnerability of cochlear nuclei to Lmx1 deficiency: abnormal patterning and implications for auditory circuitry.,2026,10.1016/j.neulet.2026.138669,https://pubmed.ncbi.nlm.nih.gov/42379263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,41437880,Dorsoventral limb patterning in paired appendages emerged via regulatory repurposing of an ancestral posterior fin module.,2026,10.1093/molbev/msaf331,https://pubmed.ncbi.nlm.nih.gov/41437880/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,40721798,Lessons learned from a muscle study in nail-patella syndrome.,2025,10.1186/s13023-025-03911-0,https://pubmed.ncbi.nlm.nih.gov/40721798/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,40168115,&lt;i&gt;LMX1B&lt;/i&gt; missense-perturbation of regulatory element footprints disrupts serotonergic forebrain axon arborization.,2025,10.1073/pnas.2411716122,https://pubmed.ncbi.nlm.nih.gov/40168115/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,41992156,Case report: dual pathology of LMX1B-associated nephropathy and iga nephropathy in a middle-aged woman.,2026,10.1186/s12882-026-04973-3,https://pubmed.ncbi.nlm.nih.gov/41992156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,42397421,Atypical renal phenotype with tubular proteinuria and hypercalciuria in siblings with nail-patella syndrome: evidence for a dual genetic diagnosis.,2026,10.1007/s00467-026-07446-9,https://pubmed.ncbi.nlm.nih.gov/42397421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,40560571,Serotonin neurons are necessary for tonic sodium intake inhibition.,2025,10.1152/ajpregu.00029.2025,https://pubmed.ncbi.nlm.nih.gov/40560571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,42320467,The origin and evolution of dorsal determination mechanisms in vertebrate paired appendages.,2026,10.1016/j.cub.2026.05.046,https://pubmed.ncbi.nlm.nih.gov/42320467/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,41249554,Clinicopathological characteristics and cyclosporine-responsive proteinuria in nail-patella syndrome with a novel LMX1B mutation.,2026,10.1007/s00467-025-07036-1,https://pubmed.ncbi.nlm.nih.gov/41249554/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,42305510,Identification and validation of tumor microenvironment remodeling markers associated with prognosis in differentiated thyroid cancer.,2026,10.21037/tcr-2026-1-0208,https://pubmed.ncbi.nlm.nih.gov/42305510/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,40403211,Molecular Landscape of Endometrial Stromal Tumors.,2025,10.1200/po-24-00779,https://pubmed.ncbi.nlm.nih.gov/40403211/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,37036692,LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons.,2023,10.1083/jcb.202303008,https://pubmed.ncbi.nlm.nih.gov/37036692/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,37014324,ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience.,2023,10.1083/jcb.201910133,https://pubmed.ncbi.nlm.nih.gov/37014324/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,41596573,Spatiotemporal Regulation and Lineage Specification in Embryonic Endochondral Ossification.,2026,10.3390/ijms27020926,https://pubmed.ncbi.nlm.nih.gov/41596573/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,37225860,Phase II trial of delta-tocotrienol in neoadjuvant breast cancer with evaluation of treatment response using ctDNA.,2023,10.1038/s41598-023-35362-7,https://pubmed.ncbi.nlm.nih.gov/37225860/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,39123228,Non-dialyzable uremic toxins and renal tubular cell damage in CKD patients: a systems biology approach.,2024,10.1186/s40001-024-01951-z,https://pubmed.ncbi.nlm.nih.gov/39123228/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,36007322,Triphenyl phosphate disturbs placental tryptophan metabolism and induces neurobehavior abnormal in male offspring.,2022,10.1016/j.ecoenv.2022.113978,https://pubmed.ncbi.nlm.nih.gov/36007322/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,34440426,LMX1B Locus Associated with Low-Risk Baseline Glaucomatous Features in the POAAGG Study.,2021,10.3390/genes12081252,https://pubmed.ncbi.nlm.nih.gov/34440426/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,32960116,LMX1B-associated gankyrin expression predicts poor prognosis in glioma patients.,2020,10.1177/0300060520954764,https://pubmed.ncbi.nlm.nih.gov/32960116/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,40272416,Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma.,2025,10.7554/elife.105576,https://pubmed.ncbi.nlm.nih.gov/40272416/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,36835019,Prolonged Differentiation of Neuron-Astrocyte Co-Cultures Results in Emergence of Dopaminergic Neurons.,2023,10.3390/ijms24043608,https://pubmed.ncbi.nlm.nih.gov/36835019/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LMX1B,ENSG00000136944,Unsafe,30977041,Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin.,2019,10.1007/s12264-019-00373-w,https://pubmed.ncbi.nlm.nih.gov/30977041/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,42674817,Integrated Immunotherapy Target Atlas for Ewing Sarcoma.,2026,10.21873/cgp.20605,https://pubmed.ncbi.nlm.nih.gov/42674817/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,42613899,Whole Exome Sequencing Identified a Novel Mutation in the LOXHD1 Gene in Consanguineous Iranian Families With Hearing Loss.,2026,10.1002/jcla.70327,https://pubmed.ncbi.nlm.nih.gov/42613899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,42131115,Identification of Novel &lt;i&gt;LOXHD1&lt;/i&gt; Variants in Chinese Patients with Non-Syndromic Hearing Loss.,2026,10.26599/joto.2026.9540055,https://pubmed.ncbi.nlm.nih.gov/42131115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,40234527,LOXHD1 is an oncofusion-regulated antigen of ewing sarcoma.,2025,10.1038/s41598-025-96877-9,https://pubmed.ncbi.nlm.nih.gov/40234527/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,40244234,From Genes to Disease: Reassessing &lt;i&gt;LOXHD1&lt;/i&gt; and &lt;i&gt;AGBL1&lt;/i&gt;'s Contribution to Fuchs' Dystrophy.,2025,10.3390/ijms26073343,https://pubmed.ncbi.nlm.nih.gov/40244234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,40771159,Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis-Associated Interstitial Lung Disease.,2026,10.1002/acr.25619,https://pubmed.ncbi.nlm.nih.gov/40771159/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,42231373,Molecular diagnosis of non-syndromic hearing loss in seven Iranian families using whole-exome sequencing.,2026,10.1186/s12920-026-02403-9,https://pubmed.ncbi.nlm.nih.gov/42231373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,39256406,LOXHD1 is indispensable for maintaining TMC1 auditory mechanosensitive channels at the site of force transmission.,2024,10.1038/s41467-024-51850-4,https://pubmed.ncbi.nlm.nih.gov/39256406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,42180433,Targeted sequencing with single-molecule molecular inversion probes highlights a gap in understanding the cause of Fuchs endothelial corneal dystrophy.,2025,,https://pubmed.ncbi.nlm.nih.gov/42180433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,40387827,TCR-Based Therapy Directed against Kallikrein-Related Peptidase 4 Is Safe and Effective against Prostate Cancer.,2025,10.1158/2326-6066.cir-24-0119,https://pubmed.ncbi.nlm.nih.gov/40387827/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,37441688,"Systematic review of SLC4A11, ZEB1, LOXHD1, and AGBL1 variants in the development of Fuchs' endothelial corneal dystrophy.",2023,10.3389/fmed.2023.1153122,https://pubmed.ncbi.nlm.nih.gov/37441688/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,35705030,Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1.,2022,10.1016/j.celrep.2022.110971,https://pubmed.ncbi.nlm.nih.gov/35705030/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,41071356,LOXHD1b knockout alters swimming behavior in zebrafish.,2025,10.1007/s00441-025-04005-w,https://pubmed.ncbi.nlm.nih.gov/41071356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,41774747,Integrating sequence-based GWAS and comparative genomic analysis reveals conservation and species-specificity of putative functional variants influencing tail length and tail abnormalities in pigs and sheep.,2026,10.1371/journal.pone.0343836,https://pubmed.ncbi.nlm.nih.gov/41774747/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,41367487,Whole Genome Sequencing Improves the Identification of Pathogenic and Novel Variation in Nonsyndromic Hearing Loss.,2025,10.1155/humu/6371082,https://pubmed.ncbi.nlm.nih.gov/41367487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,40365278,Shh agonist enhances maturation in homotypic Lgr5-positive inner ear organoids.,2025,10.7150/thno.107345,https://pubmed.ncbi.nlm.nih.gov/40365278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,39757762,Multi-omics profiling reveals key factors involved in Ewing sarcoma metastasis.,2025,10.1002/1878-0261.13788,https://pubmed.ncbi.nlm.nih.gov/39757762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,39773702,Whole-exome sequencing uncovers the genetic basis of hereditary concomitant exotropia in ten Chinese pedigrees.,2025,10.1186/s12920-024-02078-0,https://pubmed.ncbi.nlm.nih.gov/39773702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,33707295,Loxhd1 Mutations Cause Mechanotransduction Defects in Cochlear Hair Cells.,2021,10.1523/jneurosci.0975-20.2021,https://pubmed.ncbi.nlm.nih.gov/33707295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,36505516,Loxhd1b inhibits the hair cell development in zebrafish: Possible relation to the BDNF/TrkB/ERK pathway.,2022,10.3389/fncel.2022.1065309,https://pubmed.ncbi.nlm.nih.gov/36505516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,37474886,"Copper Exposure Induced Chicken Hepatotoxicity: Involvement of Ferroptosis Mediated by Lipid Peroxidation, Ferritinophagy, and Inhibition of FSP1-CoQ10 and Nrf2/SLC7A11/GPX4 Axis.",2024,10.1007/s12011-023-03773-2,https://pubmed.ncbi.nlm.nih.gov/37474886/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,34122521,Prognostic Immune-Related Genes of Patients With Ewing's Sarcoma.,2021,10.3389/fgene.2021.669549,https://pubmed.ncbi.nlm.nih.gov/34122521/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,37760246,Canine Somatic Mutations from Whole-Exome Sequencing of B-Cell Lymphomas in Six Canine Breeds-A Preliminary Study.,2023,10.3390/ani13182846,https://pubmed.ncbi.nlm.nih.gov/37760246/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LOXHD1,ENSG00000167210,Unsafe,30973406,Association of rs613872 and Trinucleotide Repeat Expansion in the TCF4 Gene of German Patients With Fuchs Endothelial Corneal Dystrophy.,2019,10.1097/ico.0000000000001952,https://pubmed.ncbi.nlm.nih.gov/30973406/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,41814341,Integrated omics reveal the effects of vitamin D deficiency on gut microbiota and plasma metabolism in experimental autoimmune uveitis.,2026,10.1186/s12974-026-03765-8,https://pubmed.ncbi.nlm.nih.gov/41814341/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,41252217,Retinol tracing within murine neural retina reveals cell type-specific retinol transport and distribution.,2026,10.1172/jci198648,https://pubmed.ncbi.nlm.nih.gov/41252217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,41044262,tRF-34-86J8WPMN1E8Y2Q promotes the occurrence and development of gastric cancer by combining with LRAT.,2025,10.1007/s00432-025-06332-5,https://pubmed.ncbi.nlm.nih.gov/41044262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,42760268,Changes in gene expression associated with vitamin A metabolism in the corpora lutea and endometria during d 15 of the estrous cycle and throughout gestation in gilts.,2026,10.1093/jas/skag301,https://pubmed.ncbi.nlm.nih.gov/42760268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,41331566,A prognostic model for uveal melanoma in Asian populations: a comparative analysis of clinical features and gene expression patterns using the TRACE and TCGA data.,2025,10.1186/s12886-025-04509-7,https://pubmed.ncbi.nlm.nih.gov/41331566/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,42459125,The Ganoderma atrum Polysaccharide PSG-1 Attenuates Acrylamide-Induced Hepatotoxicity by Modulating the FXR-FGF15-Mediated Gut-Liver Axis.,2026,10.1002/mnfr.70543,https://pubmed.ncbi.nlm.nih.gov/42459125/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,42228943,Non-transcriptional activity of IRF3 promotes liver fibrosis and stress granule assembly via a dsRNA-TLR3-dependent pathway in hepatic stellate cells.,2026,10.1097/hep.0000000000001803,https://pubmed.ncbi.nlm.nih.gov/42228943/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,41517908,Prognostic Impact of Early Recurrence Following Pulsed Field Ablation: A Meta-Analysis.,2026,10.1111/jce.70245,https://pubmed.ncbi.nlm.nih.gov/41517908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,41383212,Brain Transcriptomics Reveals Molecular Mechanisms of Cave Adaptation in &lt;i&gt;Triplophysa&lt;/i&gt; Loaches.,2025,10.1002/ece3.72652,https://pubmed.ncbi.nlm.nih.gov/41383212/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,41854361,ECM1 produced by hepatic stellate cells serves as a gatekeeper of liver homeostasis in hepatic fibrosis.,2026,10.1097/hep.0000000000001715,https://pubmed.ncbi.nlm.nih.gov/41854361/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,41579973,YTHDF2-m6A regulation of DHRS3 at LRAT-organized organelle contacts orchestrates redox to drive radioresistance in esophageal squamous cell carcinoma.,2026,10.1016/j.freeradbiomed.2026.01.026,https://pubmed.ncbi.nlm.nih.gov/41579973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,39792554,The adiponectin-PPARγ axis in hepatic stellate cells regulates liver fibrosis.,2025,10.1016/j.celrep.2024.115165,https://pubmed.ncbi.nlm.nih.gov/39792554/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,39465792,Identification of prognostic biomarkers related to retinoic acid metabolism in gliomas and analysis of their impact on the immune microenvironment.,2024,10.1097/md.0000000000039836,https://pubmed.ncbi.nlm.nih.gov/39465792/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,41621736,Association between early and late atrial tachyarrhythmia recurrences after pulsed field ablation for atrial fibrillation: A systematic review and meta-analysis.,2026,10.1016/j.hrthm.2026.01.034,https://pubmed.ncbi.nlm.nih.gov/41621736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,41035698,Vitamin A deficiency attenuates cardiac rupture in &lt;i&gt;Stra6-&lt;/i&gt;deficient hearts following ischemic injury.,2025,10.3389/fcvm.2025.1626769,https://pubmed.ncbi.nlm.nih.gov/41035698/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,41300398,Multi-Omics Analysis Reveals Biaxial Regulatory Mechanisms of Cardiac Adaptation by Specialized Racing Training in Yili Horses.,2025,10.3390/biology14111609,https://pubmed.ncbi.nlm.nih.gov/41300398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,41126076,Genome loci with selection signatures revealed in a domesticated mandarin fish population.,2025,10.1186/s12864-025-12145-0,https://pubmed.ncbi.nlm.nih.gov/41126076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,42332430,Bakuchiol: From structural mimicry to systems-level skin biology.,2026,10.1111/ics.70116,https://pubmed.ncbi.nlm.nih.gov/42332430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,41194821,Targeting Angiogenesis and Visual Cycle in Age-Related Macular Degeneration: The Role of Stem Cells and Vinpocetine.,2025,10.7759/cureus.93878,https://pubmed.ncbi.nlm.nih.gov/41194821/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,39571829,Integrating transcriptomics and proteomics to understand the molecular mechanisms underlying the pathogenesis of type 2 diabetes mellitus.,2024,10.1016/j.ygeno.2024.110964,https://pubmed.ncbi.nlm.nih.gov/39571829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,42697140,"Neutral and ionic PFAS in coastal Antarctica: Global context, diagnostic ratios, and implications for long-range atmospheric transport.",2026,10.1016/j.ecoenv.2026.120752,https://pubmed.ncbi.nlm.nih.gov/42697140/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,41214191,Insight into the levels of fine particulate matter during 2016-2020 in the two largest cities of Vietnam.,2025,10.1007/s10661-025-14765-1,https://pubmed.ncbi.nlm.nih.gov/41214191/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,41346530,A randomized controlled trial study of a life review art intervention for older adults living alone.,2025,10.3389/fpsyg.2025.1669119,https://pubmed.ncbi.nlm.nih.gov/41346530/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,39933234,"Analysis of toxicity and mechanisms of busulfan in non-obstructive azoospermia: A genomic and toxicological approach integrating molecular docking, single-cell sequencing, and experimentation in vivo.",2025,10.1016/j.ecoenv.2025.117878,https://pubmed.ncbi.nlm.nih.gov/39933234/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,38925335,"Prevalence, timing, and impact of early recurrence of atrial tachyarrhythmias after pulsed field ablation: A secondary analysis of the PULSED AF trial.",2025,10.1016/j.hrthm.2024.06.036,https://pubmed.ncbi.nlm.nih.gov/38925335/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,38351234,Larvicidal and repellent effects of essential oils on the brown dog tick (Rhipicephalus sanguineus Sensu lato) with description of new larval repellent activity test method.,2024,10.1007/s10493-023-00892-2,https://pubmed.ncbi.nlm.nih.gov/38351234/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,39556054,Development and validation of the antibody-dependent cellular phagocytosis-based signature: A prognostic risk model of gastric cancer.,2025,10.17219/acem/189914,https://pubmed.ncbi.nlm.nih.gov/39556054/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,40423470,"Glacial Waters Under Threat: Risk Assessment and Source Identification of Polychlorinated Biphenyls in Meili Snow Mountains, Southeastern Tibetan Plateau.",2025,10.3390/toxics13050391,https://pubmed.ncbi.nlm.nih.gov/40423470/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,39798441,"Occurrence and bioaccumulation of organophosphate flame retardants in high-altitude regions: A comprehensive field survey in Qinghai Province, China.",2025,10.1016/j.ecoenv.2025.117715,https://pubmed.ncbi.nlm.nih.gov/39798441/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,40886596,Gut dysbiosis mediates neurotoxic effects of environmentally relevant tylosin exposure in adult zebrafish.,2025,10.1016/j.ecoenv.2025.118960,https://pubmed.ncbi.nlm.nih.gov/40886596/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,38938026,Immunisation of the somatostatin gene alters hypothalamic-pituitary-liver gene expressions and enhances growth in Dazu black goats.,2024,10.5713/ab.24.0121,https://pubmed.ncbi.nlm.nih.gov/38938026/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,41551413,Single-cell analysis of heterogeneity in reverted hiPSC-derived human hepatic stellate cells.,2026,10.1016/j.jhepr.2025.101669,https://pubmed.ncbi.nlm.nih.gov/41551413/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,18544127,Lecithin: retinol acyltransferase protein is distributed in both hepatic stellate cells and endothelial cells of normal rodent and human liver.,2009,10.1111/j.1478-3231.2008.01773.x,https://pubmed.ncbi.nlm.nih.gov/18544127/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRAT,ENSG00000121207,Unsafe,9920938,Molecular and biochemical characterization of lecithin retinol acyltransferase.,1999,10.1074/jbc.274.6.3834,https://pubmed.ncbi.nlm.nih.gov/9920938/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,41208653,Synaptic and Non-Synaptic Functions of PTPRD: A Receptor Tyrosine Phosphatase at the Crossroads of Neural Circuitry and Metabolism.,2025,10.1111/jnc.70292,https://pubmed.ncbi.nlm.nih.gov/41208653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,40386777,A comprehensive pan-cancer analysis of LRFN4: its potential as a prognostic biomarker and therapeutic target for immunotherapy.,2025,10.3389/fimmu.2025.1539076,https://pubmed.ncbi.nlm.nih.gov/40386777/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,40070576,Significance of &lt;i&gt;LRFN4&lt;/i&gt; in prognosis and tumor microenvironment of lung adenocarcinoma.,2025,10.3389/fphar.2025.1540636,https://pubmed.ncbi.nlm.nih.gov/40070576/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,40605099,"Nordihydroguaiaretic acid inhibits bladder cancer metastasis through suppression of α1,3-mannosyltransferase expression and LRFN4 N-glycosylation.",2025,10.1186/s12967-025-06571-7,https://pubmed.ncbi.nlm.nih.gov/40605099/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,41209572,Comprehensive Analysis of Aberrant m6A RNA Modifications Identifies Prognostic Biomarkers in Non-Small Cell Lung Cancer.,2025,10.7150/ijms.119651,https://pubmed.ncbi.nlm.nih.gov/41209572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,37592110,POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by Hypermethylation-Mediated LRFN4 Downregulation Following Oxaliplatin Treatment.,2023,10.1007/s11064-023-04011-w,https://pubmed.ncbi.nlm.nih.gov/37592110/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,39386842,Identification of a novel prognostic model for gastric cancer utilizing glutamine-related genes.,2024,10.1016/j.heliyon.2024.e37985,https://pubmed.ncbi.nlm.nih.gov/39386842/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,34512711,A Prognostic Signature Constructed by CTHRC1 and LRFN4 in Stomach Adenocarcinoma.,2021,10.3389/fgene.2021.646818,https://pubmed.ncbi.nlm.nih.gov/34512711/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,34981774,Crystallization and low-resolution structure solution of the SALM3-PTPσ synaptic adhesion complex.,2022,10.1107/s2053230x21012905,https://pubmed.ncbi.nlm.nih.gov/34981774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,38706895,Identification of glutamine metabolism-related gene signature to predict colorectal cancer prognosis.,2024,10.7150/jca.91687,https://pubmed.ncbi.nlm.nih.gov/38706895/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,32536098,[Expression and clinical significance of LRFN4 in colorectal cancer tissue].,2020,10.3760/cma.j.cn112137-20190905-01975,https://pubmed.ncbi.nlm.nih.gov/32536098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,34686626,Comprehensive analysis of prognostic genes in gastric cancer.,2021,10.18632/aging.203638,https://pubmed.ncbi.nlm.nih.gov/34686626/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,31089399,High SALM3 Expression in Tumor Cells and Fibroblasts Is Correlated with Poor Prognosis in Gastric Cancer Patients.,2019,10.1155/2019/8282414,https://pubmed.ncbi.nlm.nih.gov/31089399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,32665594,Structural basis of SALM3 dimerization and synaptic adhesion complex formation with PTPσ.,2020,10.1038/s41598-020-68502-4,https://pubmed.ncbi.nlm.nih.gov/32665594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,36506325,Construction of the model for predicting prognosis by key genes regulating EGFR-TKI resistance.,2022,10.3389/fgene.2022.968376,https://pubmed.ncbi.nlm.nih.gov/36506325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,27480238,SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.,2016,10.1038/ncomms12328,https://pubmed.ncbi.nlm.nih.gov/27480238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,28222338,Effect of synaptic adhesion-like molecule 3 on epileptic seizures: Evidence from animal models.,2017,10.1016/j.yebeh.2016.11.023,https://pubmed.ncbi.nlm.nih.gov/28222338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,26321637,Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion.,2015,10.1016/j.celrep.2015.08.002,https://pubmed.ncbi.nlm.nih.gov/26321637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,34277807,Screening and prognostic value of potential biomarkers for ovarian cancer.,2021,10.21037/atm-21-2627,https://pubmed.ncbi.nlm.nih.gov/34277807/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,32908454,Establishment of a 5-gene risk model related to regulatory T cells for predicting gastric cancer prognosis.,2020,10.1186/s12935-020-01502-6,https://pubmed.ncbi.nlm.nih.gov/32908454/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRFN4,ENSG00000173621,Unsafe,36699465,Screening and identifying a novel M-MDSCs-related gene signature for predicting prognostic risk and immunotherapeutic responses in patients with lung adenocarcinoma.,2022,10.3389/fgene.2022.989141,https://pubmed.ncbi.nlm.nih.gov/36699465/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRGUK,ENSG00000155530,Unsafe,42493466,Biallelic Truncating Variant in LRGUK Is Associated With Severe Multiple Morphological Abnormalities of the Sperm Flagella and Sperm Nuclear Defects in Humans.,2026,10.1111/cge.70220,https://pubmed.ncbi.nlm.nih.gov/42493466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRGUK,ENSG00000155530,Unsafe,41391574,Effects of paternal 5G RFR exposure on health of male offspring mice.,2026,10.1016/j.reprotox.2025.109139,https://pubmed.ncbi.nlm.nih.gov/41391574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRGUK,ENSG00000155530,Unsafe,38884051,Unraveling the Genetic Basis of Combined Deafness and Male Infertility Phenotypes through High-Throughput Sequencing in a Unique Cohort from South India.,2024,10.1002/ggn2.202300206,https://pubmed.ncbi.nlm.nih.gov/38884051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRGUK,ENSG00000155530,Unsafe,25781171,LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility.,2015,10.1371/journal.pgen.1005090,https://pubmed.ncbi.nlm.nih.gov/25781171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRGUK,ENSG00000155530,Unsafe,34083607,Composition and function of the C1b/C1f region in the ciliary central apparatus.,2021,10.1038/s41598-021-90996-9,https://pubmed.ncbi.nlm.nih.gov/34083607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRGUK,ENSG00000155530,Unsafe,32174164,Long noncoding RNAs expression profile and long noncoding RNA-mediated competing endogenous RNA network in nonobstructive azoospermia patients.,2020,10.2217/epi-2020-0008,https://pubmed.ncbi.nlm.nih.gov/32174164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRGUK,ENSG00000155530,Unsafe,28003339,LRGUK1 is part of a multiprotein complex required for manchette function and male fertility.,2017,10.1096/fj.201600909r,https://pubmed.ncbi.nlm.nih.gov/28003339/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRGUK,ENSG00000155530,Unsafe,18498660,Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study.,2008,10.1186/1471-2350-9-46,https://pubmed.ncbi.nlm.nih.gov/18498660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRIT1,ENSG00000148602,Unsafe,42201444,"N-Glycosylation of mGluR6 Modulates Receptor Cell-Surface Transport, G-Protein Coupling, and Interactions With Synaptic Adhesion Molecules.",2026,10.1007/s12031-026-02546-5,https://pubmed.ncbi.nlm.nih.gov/42201444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRIT1,ENSG00000148602,Unsafe,29590623,LRIT1 Modulates Adaptive Changes in Synaptic Communication of Cone Photoreceptors.,2018,10.1016/j.celrep.2018.03.008,https://pubmed.ncbi.nlm.nih.gov/29590623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRIT1,ENSG00000148602,Unsafe,29590622,"Lrit1, a Retinal Transmembrane Protein, Regulates Selective Synapse Formation in Cone Photoreceptor Cells and Visual Acuity.",2018,10.1016/j.celrep.2018.03.007,https://pubmed.ncbi.nlm.nih.gov/29590622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,42583477,Alzheimer's Disease DNA Methylation Index (AD-DMI) and its Association with Late-Life Cognitive Function.,2026,10.1038/s44400-026-00085-9,https://pubmed.ncbi.nlm.nih.gov/42583477/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,42754234,Primary Large B-Cell Lymphomas of Immune-Privileged Sites With IRF4 Rearrangement: Clinicopathological and Molecular Characterization.,2026,10.1016/j.modpat.2026.101084,https://pubmed.ncbi.nlm.nih.gov/42754234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,41922918,Genetic architecture of sleep in a genome wide association study of device measured sleep traits.,2026,10.1038/s41467-026-71252-y,https://pubmed.ncbi.nlm.nih.gov/41922918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,41743182,Correlation analysis between plasma circulating tumour deoxyribonucleic acid variations and survival in patients with hepatocellular carcinoma.,2025,10.3389/fonc.2025.1653475,https://pubmed.ncbi.nlm.nih.gov/41743182/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,41065506,LRP1b Loss Predicts Sensitivity to Immunotherapy in Patients with NSCLC: An Analysis of the Phase III CheckMate-026 Randomized Trial.,2025,10.1158/1078-0432.ccr-25-0952,https://pubmed.ncbi.nlm.nih.gov/41065506/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,42865727,Identification and validation of feature genes using a ferroptosis-informed analytical framework in medulloblastoma.,2026,10.3389/fped.2026.1891716,https://pubmed.ncbi.nlm.nih.gov/42865727/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,40346661,DNMT3B promotes the progression of pheochromocytoma by mediating the hypermethylation of LRP1B promoter.,2025,10.1186/s13072-025-00592-8,https://pubmed.ncbi.nlm.nih.gov/40346661/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,42105187,Combining single cell and bulk transcriptomics with Mendelian randomization identifies gut microbiota related prognostic genes and mechanisms in thyroid cancer.,2026,10.1007/s12672-026-05132-8,https://pubmed.ncbi.nlm.nih.gov/42105187/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,40170839,Molecular characteristics and cancer immunity of LRP1B and its relationship with the Hedgehog signaling pathway in colorectal cancer.,2025,10.3389/fimmu.2025.1567102,https://pubmed.ncbi.nlm.nih.gov/40170839/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,42714781,Unveiling novel transcriptomic prognostic biomarkers for specific breast cancer subtypes and treatment regimens.,2026,10.1007/s43440-026-00895-x,https://pubmed.ncbi.nlm.nih.gov/42714781/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,42724192,Molecular differences between poorly and well/moderately differentiated lung adenocarcinoma and their clinical implications.,2026,10.21037/jtd-2026-1344,https://pubmed.ncbi.nlm.nih.gov/42724192/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,40184130,Identification of hub genes and potential molecular mechanisms related to radiotherapy in thyroid cancer.,2025,10.1097/md.0000000000041140,https://pubmed.ncbi.nlm.nih.gov/40184130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,39770638,Targeted Variant Assessments of Human Endogenous Retroviral Regions in Whole Genome Sequencing Data Reveal Retroviral Variants Associated with Papillary Thyroid Cancer.,2024,10.3390/microorganisms12122435,https://pubmed.ncbi.nlm.nih.gov/39770638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,41979358,Single-Nucleus RNA Sequencing Reveals Muscle Fiber Cell Heterogeneity During Human Skeletal Muscle Aging.,2026,10.1111/acel.70485,https://pubmed.ncbi.nlm.nih.gov/41979358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,41725028,Whole Exome Sequencing of Feline Oral Squamous Cell Carcinoma Reveals Genomic Parallels With Human Head and Neck Squamous Cell Carcinoma.,2026,10.1111/vco.70054,https://pubmed.ncbi.nlm.nih.gov/41725028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,42415854,"Integrated Genomic, Transcriptomic, and Circulating Biomarkers Predict Benefit to Immune Checkpoint Inhibitor Plus Chemotherapy in Advanced Non-Small Cell Lung Cancer.",2026,10.1002/mco2.70846,https://pubmed.ncbi.nlm.nih.gov/42415854/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,41696008,Genome-wide association study of nutrient composition in meat from three two-way crossbred pig populations using whole-genome resequencing.,2026,10.3389/fvets.2026.1758076,https://pubmed.ncbi.nlm.nih.gov/41696008/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,40011914,Comprehensive genetic variant analysis reveals combination of KRAS and LRP1B as a predictive biomarker of response to immunotherapy in patients with non-small cell lung cancer.,2025,10.1186/s13046-025-03342-6,https://pubmed.ncbi.nlm.nih.gov/40011914/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,41218518,LRP1B in cancer: From a mutation landscape to predictive biomarkers for precision oncology.,2025,10.1016/j.mrrev.2025.108568,https://pubmed.ncbi.nlm.nih.gov/41218518/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,41437098,Novel insights into hypoxia-driven transcriptomic and epigenetic landscapes in grade 3 meningioma.,2025,10.1186/s12967-025-07606-9,https://pubmed.ncbi.nlm.nih.gov/41437098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,42180801,COPD-Lung Cancer Comorbidity: Mechanistic Insights and Precision Oncology Implications.,2026,10.2147/copd.s606647,https://pubmed.ncbi.nlm.nih.gov/42180801/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,39660409,LRP1B Suppresses Immunotherapy Efficacy in Lung Adenocarcinoma by Preventing Ferroptosis.,2024,10.1002/cam4.70486,https://pubmed.ncbi.nlm.nih.gov/39660409/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,41973182,Integrated network toxicology and immune profiling identify ESR1 as a potential hub linking Benzo[a]pyrene exposure to gastric cancer risk.,2026,10.1007/s12672-026-04939-9,https://pubmed.ncbi.nlm.nih.gov/41973182/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,39686583,LRP1B mutation is associated with lymph node metastasis in endometrial carcinoma: A clinical next-generation sequencing study.,2025,10.1177/03936155241304433,https://pubmed.ncbi.nlm.nih.gov/39686583/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,39678041,Discover Mutational Differences Between Lung Adenocarcinoma and Lung Squamous Cell Carcinoma and Search for More Effective Biomarkers for Immunotherapy.,2024,10.2147/cmar.s491661,https://pubmed.ncbi.nlm.nih.gov/39678041/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,42286843,Comprehensive Genomic Profiles of Patients With Biliary Tract Cancer.,2026,10.1002/cam4.71988,https://pubmed.ncbi.nlm.nih.gov/42286843/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,38381429,Total Neoadjuvant Therapy With PD-1 Blockade for High-Risk Proficient Mismatch Repair Rectal Cancer.,2024,10.1001/jamasurg.2023.7996,https://pubmed.ncbi.nlm.nih.gov/38381429/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,39193390,Efficacy and challenges of anti-PD1 in MSI-H mCRC: a case report on concurrent infections and ir-AIHA.,2024,10.3389/fonc.2024.1407312,https://pubmed.ncbi.nlm.nih.gov/39193390/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,38840771,The combination of tumor mutational burden and T-cell receptor repertoire predicts the response to immunotherapy in patients with advanced non-small cell lung cancer.,2024,10.1002/mco2.604,https://pubmed.ncbi.nlm.nih.gov/38840771/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,37057124,LRP1B mutation is associated with tumor immune microenvironment and progression-free survival in lung adenocarcinoma treated with immune checkpoint inhibitors.,2023,10.21037/tlcr-23-39,https://pubmed.ncbi.nlm.nih.gov/37057124/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP1B,ENSG00000168702,Unsafe,11384978,"The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein.",2001,10.1074/jbc.m102727200,https://pubmed.ncbi.nlm.nih.gov/11384978/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP2BP,ENSG00000109771,Unsafe,39814306,"Identification of key antifibrotic targets FPR1, TAS2R5, and LRP2BP of valsartan in diabetic nephropathy: A transcriptomics-driven study integrating machine learning, molecular docking, and dynamics simulations.",2025,10.1016/j.ijbiomac.2025.139842,https://pubmed.ncbi.nlm.nih.gov/39814306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP2BP,ENSG00000109771,Unsafe,39028495,Identification of hub genes associated with pyroptosis in diabetic nephropathy patients using integrated bioinformatic analysis.,2025,10.1007/s11255-024-04158-7,https://pubmed.ncbi.nlm.nih.gov/39028495/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP2BP,ENSG00000109771,Unsafe,33069728,Exome-Wide Association Analysis Suggests LRP2BP as a Susceptibility Gene for Endothelial Injury in Systemic Sclerosis in the Han Chinese Population.,2021,10.1016/j.jid.2020.07.039,https://pubmed.ncbi.nlm.nih.gov/33069728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP2BP,ENSG00000109771,Unsafe,29363163,LncRNA-RP11-714G18.1 suppresses vascular cell migration via directly targeting LRP2BP.,2018,10.1111/imcb.1028,https://pubmed.ncbi.nlm.nih.gov/29363163/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP2BP,ENSG00000109771,Unsafe,29523860,Allele-specific expression in a family quartet with autism reveals mono-to-biallelic switch and novel transcriptional processes of autism susceptibility genes.,2018,10.1038/s41598-018-22753-4,https://pubmed.ncbi.nlm.nih.gov/29523860/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP2BP,ENSG00000109771,Unsafe,36755113,Dynamic changes of 3'UTR length during oocyte-to-zygote transition of in vitro pig embryos.,2023,10.1111/rda.14327,https://pubmed.ncbi.nlm.nih.gov/36755113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP2BP,ENSG00000109771,Unsafe,28850114,Differential DNA methylation at birth associated with mental disorder in individuals with 22q11.2 deletion syndrome.,2017,10.1038/tp.2017.181,https://pubmed.ncbi.nlm.nih.gov/28850114/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP2BP,ENSG00000109771,Unsafe,28713971,"Systematic analysis of lncRNAs, miRNAs and mRNAs for the identification of biomarkers for osteoporosis in the mandible of ovariectomized mice.",2017,10.3892/ijmm.2017.3062,https://pubmed.ncbi.nlm.nih.gov/28713971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP2BP,ENSG00000109771,Unsafe,19809486,Comprehensive expression analysis of FSHD candidate genes at the mRNA and protein level.,2009,10.1038/ejhg.2009.62,https://pubmed.ncbi.nlm.nih.gov/19809486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP2BP,ENSG00000109771,Unsafe,15809689,Molecular cloning and characterization of a novel human gene containing 4 ankyrin repeat domains.,2005,,https://pubmed.ncbi.nlm.nih.gov/15809689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP2BP,ENSG00000109771,Unsafe,19888305,Analysis of allele-specific RNA transcription in FSHD by RNA-DNA FISH in single myonuclei.,2010,10.1038/ejhg.2009.183,https://pubmed.ncbi.nlm.nih.gov/19888305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRP2BP,ENSG00000109771,Unsafe,17151338,Expression profile of FSHD supports a link between retinal vasculopathy and muscular dystrophy.,2007,10.1212/01.wnl.0000251269.31442.d9,https://pubmed.ncbi.nlm.nih.gov/17151338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC18,ENSG00000165383,Unsafe,42380882,Multi-omics analysis reveals mechanisms of Qingying granules in treating porcine warm disease: dosage optimization and systems biology insights.,2026,10.1186/s12917-026-05664-9,https://pubmed.ncbi.nlm.nih.gov/42380882/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC18,ENSG00000165383,Unsafe,33686958,Identification of key genes in coronary artery disease: an integrative approach based on weighted gene co-expression network analysis and their correlation with immune infiltration.,2021,10.18632/aging.202638,https://pubmed.ncbi.nlm.nih.gov/33686958/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC18,ENSG00000165383,Unsafe,35885976,Microarray-Based Prediction of Polycythemia after Exposure to High Altitudes.,2022,10.3390/genes13071193,https://pubmed.ncbi.nlm.nih.gov/35885976/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC18,ENSG00000165383,Unsafe,36308435,"Trans-ancestry, Bayesian meta-analysis discovers 20 novel risk loci for inflammatory bowel disease in an African American, East Asian and European cohort.",2023,10.1093/hmg/ddac269,https://pubmed.ncbi.nlm.nih.gov/36308435/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC18,ENSG00000165383,Unsafe,22972472,An intronic variant associated with systemic lupus erythematosus changes the binding affinity of Yinyang1 to downregulate WDFY4.,2012,10.1038/gene.2012.33,https://pubmed.ncbi.nlm.nih.gov/22972472/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC18,ENSG00000165383,Unsafe,22718019,"USH1K, a novel locus for type I Usher syndrome, maps to chromosome 10p11.21-q21.1.",2012,10.1038/jhg.2012.79,https://pubmed.ncbi.nlm.nih.gov/22718019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC18,ENSG00000165383,Unsafe,23249952,Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations.,2013,10.1038/ejhg.2012.277,https://pubmed.ncbi.nlm.nih.gov/23249952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC27,ENSG00000148814,Unsafe,35455936,Proteomics and Metabolomics Profiling of Platelets and Plasma Mediators of Thrombo-Inflammation in Gestational Hypertension and Preeclampsia.,2022,10.3390/cells11081256,https://pubmed.ncbi.nlm.nih.gov/35455936/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC27,ENSG00000148814,Unsafe,31937794,Exploring the Novel Susceptibility Gene Variants for Primary Open-Angle Glaucoma in East Asian Cohorts: The GLAU-GENDISK Study.,2020,10.1038/s41598-019-57066-7,https://pubmed.ncbi.nlm.nih.gov/31937794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC27,ENSG00000148814,Unsafe,32527043,Altered Transcription Factor Binding and Gene Bivalency in Islets of Intrauterine Growth Retarded Rats.,2020,10.3390/cells9061435,https://pubmed.ncbi.nlm.nih.gov/32527043/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC27,ENSG00000148814,Unsafe,33198820,DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial.,2020,10.1186/s13073-020-00794-7,https://pubmed.ncbi.nlm.nih.gov/33198820/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC27,ENSG00000148814,Unsafe,34243768,Exposure to arsenic at different life-stages and DNA methylation meta-analysis in buccal cells and leukocytes.,2021,10.1186/s12940-021-00754-7,https://pubmed.ncbi.nlm.nih.gov/34243768/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC28,ENSG00000168904,Unsafe,33417267,miR-218 contributes to drug resistance in multiple myeloma via targeting LRRC28.,2021,10.1002/jcb.29684,https://pubmed.ncbi.nlm.nih.gov/33417267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC28,ENSG00000168904,Unsafe,23045723,The expression of leucine-rich repeat gene family members in colorectal cancer.,2012,10.1258/ebm.2012.012042,https://pubmed.ncbi.nlm.nih.gov/23045723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC28,ENSG00000168904,Unsafe,24940306,Erratum: Differential expressed genes in ECV304 Endothelial-like Cells infected with Human Cytomegalovirus.,2013,10.4314/ahs.v13i4.2,https://pubmed.ncbi.nlm.nih.gov/24940306/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC28,ENSG00000168904,Unsafe,24235919,Global analysis of differential expressed genes in ECV304 Endothelial-like cells infected with human cytomegalovirus.,2013,10.4314/ahs.v13i2.6,https://pubmed.ncbi.nlm.nih.gov/24235919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC28,ENSG00000168904,Unsafe,25086685,Injury-induced immune responses in Hydra.,2014,10.1016/j.smim.2014.06.004,https://pubmed.ncbi.nlm.nih.gov/25086685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC28,ENSG00000168904,Unsafe,17786358,Identification of differential expression of genes in hepatocellular carcinoma by suppression subtractive hybridization combined cDNA microarray.,2007,10.3892/or.18.4.943,https://pubmed.ncbi.nlm.nih.gov/17786358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC28,ENSG00000168904,Unsafe,38444027,Genomic determinants of antibody response to a typhoid vaccine in Indian recipients.,2024,10.1007/s12041-024-01463-z,https://pubmed.ncbi.nlm.nih.gov/38444027/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC34,ENSG00000171757,Unsafe,42208172,Maternal protein undernutrition during lactation reduces body weight gain and adiposity and delays pubertal onset in male Wistar offspring.,2026,10.1016/j.nut.2026.113247,https://pubmed.ncbi.nlm.nih.gov/42208172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC34,ENSG00000171757,Unsafe,42201020,Regulatory Variation at TERT and TERC Shows Limited Association with Early-Onset Alzheimer's Disease in Carriers of the Mexican Founder Mutation &lt;i&gt;PSEN1&lt;/i&gt; A431E.,2026,10.3390/medsci14020228,https://pubmed.ncbi.nlm.nih.gov/42201020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC34,ENSG00000171757,Unsafe,38091523,LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility.,2023,10.7554/elife.90095,https://pubmed.ncbi.nlm.nih.gov/38091523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC34,ENSG00000171757,Unsafe,34549596,Lrrc34 Interacts with Oct4 and Has an Impact on Telomere Length in Mouse Embryonic Stem Cells.,2021,10.1089/scd.2021.0113,https://pubmed.ncbi.nlm.nih.gov/34549596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC34,ENSG00000171757,Unsafe,39986329,"A large-scale genome-wide association study on female genital tract polyps highlights role of DNA repair, cell proliferation, and cell growth.",2025,10.1093/humrep/deaf025,https://pubmed.ncbi.nlm.nih.gov/39986329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC34,ENSG00000171757,Unsafe,32299535,Lrrc34 Is Highly Expressed in SSCs and Is Necessary for SSC Expansion In Vitro.,2020,10.24920/003680,https://pubmed.ncbi.nlm.nih.gov/32299535/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC34,ENSG00000171757,Unsafe,32051256,Variants in LRRC34 reveal distinct mechanisms for predisposition to papillary thyroid carcinoma.,2020,10.1136/jmedgenet-2019-106554,https://pubmed.ncbi.nlm.nih.gov/32051256/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC34,ENSG00000171757,Unsafe,24991885,"Lrrc34, a novel nucleolar protein, interacts with npm1 and ncl and has an impact on pluripotent stem cells.",2014,10.1089/scd.2013.0470,https://pubmed.ncbi.nlm.nih.gov/24991885/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC34,ENSG00000171757,Unsafe,34373545,Pathogenic nsSNPs that increase the risks of cancers among the Orang Asli and Malays.,2021,10.1038/s41598-021-95618-y,https://pubmed.ncbi.nlm.nih.gov/34373545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC34,ENSG00000171757,Unsafe,35073935,Variability in newborn telomere length is explained by inheritance and intrauterine environment.,2022,10.1186/s12916-021-02217-9,https://pubmed.ncbi.nlm.nih.gov/35073935/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC34,ENSG00000171757,Unsafe,32151602,Prepubertal acrylamide exposure causes dose-response decreases in spermatic production and functionality with modulation of genes involved in the spermatogenesis in rats.,2020,10.1016/j.tox.2020.152428,https://pubmed.ncbi.nlm.nih.gov/32151602/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC34,ENSG00000171757,Unsafe,34685603,Terc Gene Cluster Variants Predict Liver Telomere Length in Mice.,2021,10.3390/cells10102623,https://pubmed.ncbi.nlm.nih.gov/34685603/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC34,ENSG00000171757,Unsafe,30559463,The polygenic nature of telomere length and the anti-ageing properties of lithium.,2019,10.1038/s41386-018-0289-0,https://pubmed.ncbi.nlm.nih.gov/30559463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC34,ENSG00000171757,Unsafe,22844512,Identification of novel markers of mouse fetal ovary development.,2012,10.1371/journal.pone.0041683,https://pubmed.ncbi.nlm.nih.gov/22844512/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC34,ENSG00000171757,Unsafe,28460059,Insights into Ciliary Genes and Evolution from Multi-Level Phylogenetic Profiling.,2017,10.1093/molbev/msx146,https://pubmed.ncbi.nlm.nih.gov/28460059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC34,ENSG00000171757,Unsafe,27812514,Association between Genetic Variations Affecting Mean Telomere Length and the Prevalence of Hypertension and Coronary Heart Disease in Koreans.,2016,10.7762/cnr.2016.5.4.249,https://pubmed.ncbi.nlm.nih.gov/27812514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC34,ENSG00000171757,Unsafe,26792595,Genetic susceptibility loci of idiopathic interstitial pneumonia do not represent risk for systemic sclerosis: a case control study in Caucasian patients.,2016,10.1186/s13075-016-0923-3,https://pubmed.ncbi.nlm.nih.gov/26792595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC34,ENSG00000171757,Unsafe,40680372,Epigenome-wide association study of gestational exposure to organophosphate esters and replacement brominated flame retardants with newborn DNA methylation.,2025,10.1016/j.scitotenv.2025.180079,https://pubmed.ncbi.nlm.nih.gov/40680372/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC36,ENSG00000159708,Unsafe,41604006,"A multi-algorithm machine learning framework identifies FGD5, LRRC36, C8B, and MYOC as novel diagnostic biomarkers in lung adenocarcinoma.",2026,10.1007/s12672-026-04505-3,https://pubmed.ncbi.nlm.nih.gov/41604006/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC36,ENSG00000159708,Unsafe,41880302,Composite selection signal analysis: Uncovering candidate genes and quantitative trait loci in Indian sheep breeds.,2026,10.1371/journal.pone.0344299,https://pubmed.ncbi.nlm.nih.gov/41880302/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,41335165,Mendelian randomization analysis integrating GWAS and eQTL data identified potential regulatory genes associated with prostate cancer in neural cells.,2025,10.1007/s12672-025-03711-9,https://pubmed.ncbi.nlm.nih.gov/41335165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,42791463,Brain-Wide Multi-Trait Genetic Integration Implicates Lysosomal and Metabolic Axes Linking Visual Disturbance and Alzheimer's Disease.,2026,10.1007/s12035-026-06211-1,https://pubmed.ncbi.nlm.nih.gov/42791463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,42894650,Identification of platelet-derived biomarker in a cohort of Parkinson's disease.,2027,10.1016/j.gendis.2026.102171,https://pubmed.ncbi.nlm.nih.gov/42894650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,42019823,Integrative multi-omics implicates a CTSB/ITIH-ECM axis in autism spectrum disorder.,2026,10.1016/j.nbd.2026.107402,https://pubmed.ncbi.nlm.nih.gov/42019823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,40055946,Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells.,2025,10.1002/mds.30150,https://pubmed.ncbi.nlm.nih.gov/40055946/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,40411683,Leveraging Alzheimer's Disease Omics to Identify Pleiotropic Genes Contributing to Neurodegeneration in Primary Open-Angle Glaucoma.,2025,10.1007/s12035-025-05074-2,https://pubmed.ncbi.nlm.nih.gov/40411683/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,37744342,Chimeric RNAs reveal putative neoantigen peptides for developing tumor vaccines for breast cancer.,2023,10.3389/fimmu.2023.1188831,https://pubmed.ncbi.nlm.nih.gov/37744342/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,38454350,Genome-wide association studies highlight novel risk loci for septal defects and left-sided congenital heart defects.,2024,10.1186/s12864-024-10172-x,https://pubmed.ncbi.nlm.nih.gov/38454350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,39526243,Proteome-wide Mendelian randomization provides novel insights into the pathogenesis and druggable targets of osteoporosis.,2024,10.3389/fmed.2024.1426261,https://pubmed.ncbi.nlm.nih.gov/39526243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,41559749,Integration of clinical and proteomic risk factors enhances prognostic modelling of incident vascular complications in type 2 diabetes.,2026,10.1186/s12933-026-03083-6,https://pubmed.ncbi.nlm.nih.gov/41559749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,33491552,Differential regulation of LRRC37A2 in gastric cancer by DNA methylation.,2022,10.1080/15592294.2021.1878724,https://pubmed.ncbi.nlm.nih.gov/33491552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,34504106,A transcriptome-wide association study identifies susceptibility genes for Parkinson's disease.,2021,10.1038/s41531-021-00221-7,https://pubmed.ncbi.nlm.nih.gov/34504106/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,37534731,Shared Genetics and Comorbid Genes of Amyotrophic Lateral Sclerosis and Parkinson's Disease.,2023,10.1002/mds.29572,https://pubmed.ncbi.nlm.nih.gov/37534731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,37996402,Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation.,2023,10.1038/s41467-023-43485-8,https://pubmed.ncbi.nlm.nih.gov/37996402/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,37491937,"Single-Nucleus Transcriptome Profiling of Dorsolateral Prefrontal Cortex: Mechanistic Roles for Neuronal Gene Expression, Including the 17q21.31 Locus, in PTSD Stress Response.",2023,10.1176/appi.ajp.20220478,https://pubmed.ncbi.nlm.nih.gov/37491937/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,36794676,An integrated strategy to identify COVID-19 causal genes and characteristics represented by LRRC37A2.,2023,10.1002/jmv.28585,https://pubmed.ncbi.nlm.nih.gov/36794676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,33883344,Detection of novel and recurrent conjoined genes in non-Hodgkin B-cell lymphoma.,2021,10.3960/jslrt.20033,https://pubmed.ncbi.nlm.nih.gov/33883344/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,36716280,Identifying Biomarkers Using Support Vector Machine to Understand the Racial Disparity in Triple-Negative Breast Cancer.,2023,10.1089/cmb.2022.0422,https://pubmed.ncbi.nlm.nih.gov/36716280/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,35774514,A Novel Defined Super-Enhancer Associated Gene Signature to Predict Prognosis in Patients With Diffuse Large B-Cell Lymphoma.,2022,10.3389/fgene.2022.827840,https://pubmed.ncbi.nlm.nih.gov/35774514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,33804213,Transcript Variants of Genes Involved in Neurodegeneration Are Differentially Regulated by the APOE and MAPT Haplotypes.,2021,10.3390/genes12030423,https://pubmed.ncbi.nlm.nih.gov/33804213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC37A2,ENSG00000238083,Unsafe,32829096,Screening non-MAPT genes of the Chr17q21 H1 haplotype in Parkinson's disease.,2020,10.1016/j.parkreldis.2020.07.022,https://pubmed.ncbi.nlm.nih.gov/32829096/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,36798137,LRRC3B and its promoter hypomethylation status predicts response to anti-PD-1 based immunotherapy.,2023,10.3389/fimmu.2023.959868,https://pubmed.ncbi.nlm.nih.gov/36798137/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,40488840,Epigenetic biomarkers of mortality risk in mice under chronic social stress.,2026,10.1007/s11357-025-01721-7,https://pubmed.ncbi.nlm.nih.gov/40488840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,34178643,LRRC3B Polymorphisms Contributed to Breast Cancer Susceptibility in Chinese Han Population.,2021,10.3389/fonc.2021.657168,https://pubmed.ncbi.nlm.nih.gov/34178643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,30185536,DNA Methylation of LRRC3B: A Biomarker for Survival of Early-Stage Non-Small Cell Lung Cancer Patients.,2018,10.1158/1055-9965.epi-18-0454,https://pubmed.ncbi.nlm.nih.gov/30185536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,29085514,Protective role of LRRC3B in preventing breast cancer metastasis and recurrence post-bupivacaine.,2017,10.3892/ol.2017.6773,https://pubmed.ncbi.nlm.nih.gov/29085514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,33173602,GLAD-PCR Assay of R(5mC)GY Sites in the Regulatory Region of Tumor-Suppressor Genes Associated with Gastric Cancer.,2020,10.32607/actanaturae.11070,https://pubmed.ncbi.nlm.nih.gov/33173602/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,27118644,[LRRC3B is Downregulated in Non-small Cell Lung Cancer and Connected with Cell Proliferation and Invasion].,2016,10.3779/j.issn.1009-3419.2016.04.01,https://pubmed.ncbi.nlm.nih.gov/27118644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,26276358,LRRC3B is downregulated in non-small-cell lung cancer and inhibits cancer cell proliferation and invasion.,2016,10.1007/s13277-015-3833-0,https://pubmed.ncbi.nlm.nih.gov/26276358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,24839112,The clinical value of LRRC3B gene expression and promoter hypermethylation in breast carcinomas.,2014,10.1007/s12013-014-0018-1,https://pubmed.ncbi.nlm.nih.gov/24839112/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,33076993,Serious neonatal morbidities are associated with differences in DNA methylation among very preterm infants.,2020,10.1186/s13148-020-00942-1,https://pubmed.ncbi.nlm.nih.gov/33076993/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,24337411,Validation of nucleolar protein 4 as a novel methylated tumor suppressor gene in head and neck cancer.,2014,10.3892/or.2013.2927,https://pubmed.ncbi.nlm.nih.gov/24337411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,23202957,NotI microarrays: novel epigenetic markers for early detection and prognosis of high grade serous ovarian cancer.,2012,10.3390/ijms131013352,https://pubmed.ncbi.nlm.nih.gov/23202957/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,27725787,Concentration and Methylation of Cell-Free DNA from Blood Plasma as Diagnostic Markers of Renal Cancer.,2016,10.1155/2016/3693096,https://pubmed.ncbi.nlm.nih.gov/27725787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,20080187,Odor-evoked gene regulation and visualization in olfactory receptor neurons.,2010,10.1016/j.mcn.2010.01.002,https://pubmed.ncbi.nlm.nih.gov/20080187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,24977159,Epigenetic alterations of chromosome 3 revealed by NotI-microarrays in clear cell renal cell carcinoma.,2014,10.1155/2014/735292,https://pubmed.ncbi.nlm.nih.gov/24977159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,23478628,Novel tumor suppressor candidates on chromosome 3 revealed by NotI-microarrays in cervical cancer.,2013,10.4161/epi.24233,https://pubmed.ncbi.nlm.nih.gov/23478628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,22101383,Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter             in clear cell renal cell carcinomas.,2012,10.3892/mmr.2011.681,https://pubmed.ncbi.nlm.nih.gov/22101383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,23923051,Transcriptome analysis of duck liver and identification of differentially expressed transcripts in response to duck hepatitis A virus genotype C infection.,2013,10.1371/journal.pone.0071051,https://pubmed.ncbi.nlm.nih.gov/23923051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,22321817,LRRC3B gene is frequently epigenetically inactivated in several epithelial malignancies and inhibits cell growth and replication.,2012,10.1016/j.biochi.2012.01.019,https://pubmed.ncbi.nlm.nih.gov/22321817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,18757430,"LRRC3B, encoding a leucine-rich repeat-containing protein, is a putative tumor suppressor gene in gastric cancer.",2008,10.1158/0008-5472.can-08-0667,https://pubmed.ncbi.nlm.nih.gov/18757430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,30979737,Activity and Safety of Palbociclib in Patients with Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib: A Biomarker-driven Phase II Study.,2019,10.1158/1078-0432.ccr-18-3127,https://pubmed.ncbi.nlm.nih.gov/30979737/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC3B,ENSG00000179796,Unsafe,28408707,Admixture Mapping of Subclinical Atherosclerosis and Subsequent Clinical Events Among African Americans in 2 Large Cohort Studies.,2017,10.1161/circgenetics.116.001569,https://pubmed.ncbi.nlm.nih.gov/28408707/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,39515584,The mechanism of Ca&lt;sup&gt;2+&lt;/sup&gt;-independent activation of BKCa channels in mouse inner hair cells and the crucial role of the BK channels in auditory perception.,2025,10.1016/j.jbc.2024.107970,https://pubmed.ncbi.nlm.nih.gov/39515584/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,35014034,The LRRC family of BK channel regulatory subunits: potential roles in health and disease.,2022,10.1113/jp281952,https://pubmed.ncbi.nlm.nih.gov/35014034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,36132147,Use of long non-coding RNAs for the molecular diagnosis of papillary thyroid cancer.,2022,10.3389/fonc.2022.924409,https://pubmed.ncbi.nlm.nih.gov/36132147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,38492360,LncRNAs associated with lymph node metastasis in thyroid cancer based on TCGA database.,2024,10.1016/j.prp.2024.155255,https://pubmed.ncbi.nlm.nih.gov/38492360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,39498893,Pharmacological inhibition of KSper impairs flagellar pH homeostasis of human spermatozoa.,2025,10.1111/andr.13796,https://pubmed.ncbi.nlm.nih.gov/39498893/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,32564653,The Slo3/Lrrc52 complex is sensitive to phosphoinositides.,2020,10.1080/19336950.2020.1778393,https://pubmed.ncbi.nlm.nih.gov/32564653/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,34980136,Homozygous mutation in SLO3 leads to severe asthenoteratozoospermia due to acrosome hypoplasia and mitochondrial sheath malformations.,2022,10.1186/s12958-021-00880-4,https://pubmed.ncbi.nlm.nih.gov/34980136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,31855284,LRRC52-AS1 is associated with clinical progression and regulates cell migration and invasion in papillary thyroid cancer.,2020,10.1111/1440-1681.13229,https://pubmed.ncbi.nlm.nih.gov/31855284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,31348683,Expression of the LRRC52 γ subunit (γ2) may provide Ca2+-independent activation of BK currents in mouse inner hair cells.,2019,10.1096/fj.201900701rr,https://pubmed.ncbi.nlm.nih.gov/31348683/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,31451634,LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells.,2019,10.1073/pnas.1907065116,https://pubmed.ncbi.nlm.nih.gov/31451634/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,35104503,"The leucine-rich repeat domains of BK channel auxiliary γ subunits regulate their expression, trafficking, and channel-modulation functions.",2022,10.1016/j.jbc.2022.101664,https://pubmed.ncbi.nlm.nih.gov/35104503/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,25675513,SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility.,2015,10.1073/pnas.1423869112,https://pubmed.ncbi.nlm.nih.gov/25675513/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,35039093,Epigenetics of single-site and multi-site atherosclerosis in African Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA).,2022,10.1186/s13148-022-01229-3,https://pubmed.ncbi.nlm.nih.gov/35039093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,22084117,"LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel.",2011,10.1073/pnas.1111104108,https://pubmed.ncbi.nlm.nih.gov/22084117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,31665287,Human sperm ion channel (dys)function: implications for fertilization.,2019,10.1093/humupd/dmz032,https://pubmed.ncbi.nlm.nih.gov/31665287/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,22547800,BK potassium channel modulation by leucine-rich repeat-containing proteins.,2012,10.1073/pnas.1205435109,https://pubmed.ncbi.nlm.nih.gov/22547800/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,28600779,The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes.,2017,10.1007/s00439-017-1821-8,https://pubmed.ncbi.nlm.nih.gov/28600779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,31496875,"Onion peel extract and its constituent, quercetin inhibits human Slo3 in a pH and calcium dependent manner.",2019,10.4196/kjpp.2019.23.5.381,https://pubmed.ncbi.nlm.nih.gov/31496875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,25360119,Regulation of BK channels by auxiliary γ subunits.,2014,10.3389/fphys.2014.00401,https://pubmed.ncbi.nlm.nih.gov/25360119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,28280418,"Intracellular calcium-dependent regulation of the sperm-specific calcium-activated potassium channel, hSlo3, by the BKCa activator LDD175.",2017,10.4196/kjpp.2017.21.2.241,https://pubmed.ncbi.nlm.nih.gov/28280418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC52,ENSG00000162763,Unsafe,27052499,Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF.,2016,10.1093/humrep/dew056,https://pubmed.ncbi.nlm.nih.gov/27052499/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC63,ENSG00000173988,Unsafe,42749426,Transcriptomic landscape of airway epithelial repair: Contrasting acute and chronic injury in mustard lung and COPD.,2026,10.1016/j.jgeb.2026.100756,https://pubmed.ncbi.nlm.nih.gov/42749426/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC63,ENSG00000173988,Unsafe,32885674,Identification of key factors associated with early- and late-onset ovarian serous cystadenocarcinoma.,2020,10.2217/fon-2020-0668,https://pubmed.ncbi.nlm.nih.gov/32885674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC63,ENSG00000173988,Unsafe,31650361,Dysregulated Transcription Factor TFAP2A After Peripheral Nerve Injury Modulated Schwann Cell Phenotype.,2019,10.1007/s11064-019-02898-y,https://pubmed.ncbi.nlm.nih.gov/31650361/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC63,ENSG00000173988,Unsafe,27659016,Hypoxia-Inducible Factor 2α Mutation-Related Paragangliomas Classify as Discrete Pseudohypoxic Subcluster.,2016,10.1016/j.neo.2016.07.008,https://pubmed.ncbi.nlm.nih.gov/27659016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC71,ENSG00000160838,Unsafe,42167576,"LRRC71 is essential for sperm motility, fertilization, and male fertility.",2026,10.1016/j.jbc.2026.113176,https://pubmed.ncbi.nlm.nih.gov/42167576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC71,ENSG00000160838,Unsafe,42492775,LRRC71 stabilizes SEPT4 protein to ensure sperm annulus integrity and male fertility.,2026,10.1016/j.jgg.2026.07.008,https://pubmed.ncbi.nlm.nih.gov/42492775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC71,ENSG00000160838,Unsafe,39733410,The G Protein-Coupled Receptor-Related Gene Signatures for Diagnosis and Prognosis in Glioblastoma: A Deep Learning Model Using RNA-Seq Data.,2024,10.31557/apjcp.2024.25.12.4201,https://pubmed.ncbi.nlm.nih.gov/39733410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC71,ENSG00000160838,Unsafe,35044082,Identification of a glioma functional network from gene fitness data using machine learning.,2022,10.1111/jcmm.17182,https://pubmed.ncbi.nlm.nih.gov/35044082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC73,ENSG00000204052,Unsafe,37056868,Comprehensive analysis of transcriptome-wide expression patterns and a circRNA/lncRNA-miRNA-mRNA network in the pathogenesis of cerebral ischemia in Rattus norvegicus.,2023,,https://pubmed.ncbi.nlm.nih.gov/37056868/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,42790701,Biosensor cell array reveals temporal GABA secretion dynamics from pancreatic islets.,2026,10.1016/j.molmet.2026.102447,https://pubmed.ncbi.nlm.nih.gov/42790701/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,41740631,Subunit-specific roles of LRRC8 proteins in determining glutamate permeability of astrocytic volume-regulated anion channels.,2026,10.1152/ajpcell.00597.2025,https://pubmed.ncbi.nlm.nih.gov/41740631/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,42346954,LRRC8D Suppresses Prostate Cancer Growth and Enhances Platinum Sensitivity via Modulation of CAV-1/STAT3 Signaling.,2026,10.3390/membranes16060198,https://pubmed.ncbi.nlm.nih.gov/42346954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,41053424,NAA60 facilitates LRRC8A- and LRRC8D-mediated platinum drug uptake.,2025,10.1038/s42003-025-08826-x,https://pubmed.ncbi.nlm.nih.gov/41053424/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,42310796,Hypoxia and lactate metabolism-related gene COL5A3 promotes triple negative breast cancer progression via DDR1/FAK/PI3K/AKT pathway.,2026,10.1186/s13062-026-00872-7,https://pubmed.ncbi.nlm.nih.gov/42310796/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,40136675,Lateral Ventricular Neural Stem Cells Provide Negative Feedback to Circuit Activation Through GABAergic Signaling.,2025,10.3390/cells14060426,https://pubmed.ncbi.nlm.nih.gov/40136675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,41388024,Assembly and lipid-gating of LRRC8A:D volume-regulated anion channels.,2025,10.1038/s41467-025-67052-5,https://pubmed.ncbi.nlm.nih.gov/41388024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,41601671,Multi-omics integration identifies NK cell dysregulation and a five-gene diagnostic signature in major depressive disorder.,2025,10.3389/fimmu.2025.1700629,https://pubmed.ncbi.nlm.nih.gov/41601671/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,41300786,Chromothriptic Translocation t(1;18): A Paradigm of Genomic Complexity in a Child with Normal Intellectual Development and Pyridoxine-Dependent Epilepsy.,2025,10.3390/genes16111334,https://pubmed.ncbi.nlm.nih.gov/41300786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,41636028,Endothelial LRRC8C Associates With LRRC8A and LRRC8B to Regulate Vascular Reactivity and Blood Pressure.,2026,10.1161/hypertensionaha.125.25889,https://pubmed.ncbi.nlm.nih.gov/41636028/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,38838775,LRRC8/VRAC volume-regulated anion channels are crucial for hearing.,2024,10.1016/j.jbc.2024.107436,https://pubmed.ncbi.nlm.nih.gov/38838775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,36467895,Loss of the volume-regulated anion channel components LRRC8A and LRRC8D limits platinum drug efficacy.,2022,10.1158/2767-9764.crc-22-0208,https://pubmed.ncbi.nlm.nih.gov/36467895/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,35777784,Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy.,2022,10.1681/asn.2021111458,https://pubmed.ncbi.nlm.nih.gov/35777784/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,37467717,A target discovery pipeline identified ILT3 as a target for immunotherapy of multiple myeloma.,2023,10.1016/j.xcrm.2023.101110,https://pubmed.ncbi.nlm.nih.gov/37467717/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,33932953,Oxidant-resistant LRRC8A/C anion channels support superoxide production by NADPH oxidase 1.,2021,10.1113/jp281577,https://pubmed.ncbi.nlm.nih.gov/33932953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,32415200,Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation.,2020,10.1038/s42003-020-0951-z,https://pubmed.ncbi.nlm.nih.gov/32415200/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,36897307,Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly.,2023,10.7554/elife.82431,https://pubmed.ncbi.nlm.nih.gov/36897307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,36719767,Epigenome-Wide Association Study Reveals CpG Sites Associated with Thyroid Function and Regulatory Effects on &lt;i&gt;KLF9&lt;/i&gt;.,2023,10.1089/thy.2022.0373,https://pubmed.ncbi.nlm.nih.gov/36719767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,35645818,Recent Advances in the Structural Biology of the Volume-Regulated Anion Channel LRRC8.,2022,10.3389/fphar.2022.896532,https://pubmed.ncbi.nlm.nih.gov/35645818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,36474183,Differential methylation patterns in lean and obese non-alcoholic steatohepatitis-associated hepatocellular carcinoma.,2022,10.1186/s12885-022-10389-7,https://pubmed.ncbi.nlm.nih.gov/36474183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,32485798,Generation of Stable cisPt Resistant Lung Adenocarcinoma Cells.,2020,10.3390/ph13060109,https://pubmed.ncbi.nlm.nih.gov/32485798/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,33171122,LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP.,2020,10.1016/j.molcel.2020.10.021,https://pubmed.ncbi.nlm.nih.gov/33171122/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,26530471,Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs.,2015,10.15252/embj.201592409,https://pubmed.ncbi.nlm.nih.gov/26530471/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,32650679,Identification of differentially expressed and methylated genes associated with rheumatoid arthritis based on network.,2020,10.1080/08916934.2020.1786069,https://pubmed.ncbi.nlm.nih.gov/32650679/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,27764579,Specific and essential but not sufficient roles of LRRC8A in the activity of volume-sensitive outwardly rectifying anion channel (VSOR).,2017,10.1080/19336950.2016.1247133,https://pubmed.ncbi.nlm.nih.gov/27764579/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC8D,ENSG00000171492,Unsafe,19505301,Molecular signature of cell cycle exit induced in human T lymphoblasts by IL-2 withdrawal.,2009,10.1186/1471-2164-10-261,https://pubmed.ncbi.nlm.nih.gov/19505301/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC9,ENSG00000131951,Unsafe,38663672,Tissue-specific gene expression of genome-wide significant loci associated with major depressive disorder subtypes.,2024,10.1016/j.pnpbp.2024.111019,https://pubmed.ncbi.nlm.nih.gov/38663672/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC9,ENSG00000131951,Unsafe,33854844,A novel predicted ADP-ribosyltransferase-like family conserved in eukaryotic evolution.,2021,10.7717/peerj.11051,https://pubmed.ncbi.nlm.nih.gov/33854844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRC9,ENSG00000131951,Unsafe,24950139,Effects of antagonist of retinoid X receptor (UVI3003) on morphology and gene profile of Xenopus tropicalis embryos.,2014,10.1016/j.etap.2014.05.010,https://pubmed.ncbi.nlm.nih.gov/24950139/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRIQ1,ENSG00000133640,Unsafe,41850652,A Twist1-regulated distal enhancer crucial for Alx1 gene expression and function during craniofacial development.,2026,10.1016/j.ydbio.2026.03.008,https://pubmed.ncbi.nlm.nih.gov/41850652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRIQ1,ENSG00000133640,Unsafe,42262729,Retinoic Acid Informs the Positional Identity of Frontonasal Neural Crest Cells Through Alx Family of Transcription Factors.,2026,10.1096/fj.202601339r,https://pubmed.ncbi.nlm.nih.gov/42262729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRIQ1,ENSG00000133640,Unsafe,36129630,Lrriq1 is an essential factor for fertility by suppressing apoptosis.,2022,10.1007/s10815-022-02623-9,https://pubmed.ncbi.nlm.nih.gov/36129630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRIQ1,ENSG00000133640,Unsafe,34844112,Epididymal mRNA and miRNA transcriptome analyses reveal important genes and miRNAs related to sperm motility in roosters.,2022,10.1016/j.psj.2021.101558,https://pubmed.ncbi.nlm.nih.gov/34844112/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRIQ1,ENSG00000133640,Unsafe,32341457,"Genome-wide association study of semen volume, sperm concentration, testis size, and plasma inhibin B levels.",2020,10.1038/s10038-020-0757-3,https://pubmed.ncbi.nlm.nih.gov/32341457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRIQ1,ENSG00000133640,Unsafe,35117619,Candidate genes for predicting the survival of patients with gastric cancer: a study based on The Cancer Genome Atlas (TCGA) database.,2020,10.21037/tcr.2020.02.82,https://pubmed.ncbi.nlm.nih.gov/35117619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRIQ3,ENSG00000162620,Unsafe,41522471,Characterization of Korean Colorectal Cancer Reveals Novel Driver Gene and Clinically Relevant Mutations.,2026,10.1002/mco2.70584,https://pubmed.ncbi.nlm.nih.gov/41522471/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRIQ3,ENSG00000162620,Unsafe,39416266,SPHK2 Knockdown Inhibits the Proliferation and Migration of Fibroblast-Like Synoviocytes Through the IL-17 Signaling Pathway in Osteoarthritis.,2024,10.2147/jir.s476077,https://pubmed.ncbi.nlm.nih.gov/39416266/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRIQ3,ENSG00000162620,Unsafe,31748543,Identification of novel common variants associated with chronic pain using conditional false discovery rate analysis with major depressive disorder and assessment of pleiotropic effects of LRFN5.,2019,10.1038/s41398-019-0613-4,https://pubmed.ncbi.nlm.nih.gov/31748543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRIQ3,ENSG00000162620,Unsafe,34728798,"Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry.",2021,10.1038/s41380-021-01335-3,https://pubmed.ncbi.nlm.nih.gov/34728798/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRIQ3,ENSG00000162620,Unsafe,23915065,Transcription of a protein-coding gene on B chromosomes of the Siberian roe deer (Capreolus pygargus).,2013,10.1186/1741-7007-11-90,https://pubmed.ncbi.nlm.nih.gov/23915065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRRIQ3,ENSG00000162620,Unsafe,24316942,Prediction of response to preoperative chemoradiotherapy in rectal cancer by using reverse transcriptase polymerase chain reaction analysis of four genes.,2014,10.1097/01.dcr.0000437688.33795.9d,https://pubmed.ncbi.nlm.nih.gov/24316942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,42784246,Machine Learning-Assisted Multiplex Profiling of Plasma-Derived Exosomal miRNAs for Alzheimer's Disease Classification.,2026,10.1021/acssensors.6c02424,https://pubmed.ncbi.nlm.nih.gov/42784246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,41535294,Comprehensive mapping of RNA modification dynamics and crosstalk via deep learning and nanopore direct RNA-sequencing.,2026,10.1038/s41467-026-68419-y,https://pubmed.ncbi.nlm.nih.gov/41535294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,41758930,Regulatory-like FOXP3+Helios+CD4+ T conventional cells correlate with T-cell activation after Orca-T immunotherapy.,2026,10.1182/blood.2025031545,https://pubmed.ncbi.nlm.nih.gov/41758930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,40203731,Germline-specific deletion of testis-highly expressed Lrwd1 reveals nonessential roles in male fertility.,2025,10.1016/j.theriogenology.2025.117426,https://pubmed.ncbi.nlm.nih.gov/40203731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,42252581,Comments on the Evidentiary Framework of the EFCD-ESE-ORCA Guideline on Deep Caries Management.,2026,10.1111/iej.70194,https://pubmed.ncbi.nlm.nih.gov/42252581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,41385341,"Orca-T vs allogeneic hematopoietic stem cell transplantation (Precision-T): a multicenter, randomized phase 3 trial.",2026,10.1182/blood.2025031313,https://pubmed.ncbi.nlm.nih.gov/41385341/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,40747268,"The orca (&lt;i&gt;Orcinus orca&lt;/i&gt;) pituitary gland: an anatomical, immunohistochemical and ultrastructural analysis.",2025,10.3389/fnana.2025.1626079,https://pubmed.ncbi.nlm.nih.gov/40747268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,42511070,Current Advances in Cetacean Semen Cryopreservation and Their Application to Yangtze Finless Porpoise Conservation.,2026,10.3390/ani16142191,https://pubmed.ncbi.nlm.nih.gov/42511070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,42258791,"Development and Preliminary Validation of ORCA-PD, an Online Rapid Cognitive Assessment for Parkinson Disease: Mixed Methods Study.",2026,10.2196/90057,https://pubmed.ncbi.nlm.nih.gov/42258791/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,42805324,TAD Boundary Disruption in Xq27-q28 Deletions Rewires 3D Chromatin Architecture and May Predispose to Primary Skewed X Chromosome Inactivation.,2026,10.1016/j.jmb.2026.170040,https://pubmed.ncbi.nlm.nih.gov/42805324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,42455828,Concentrations of essential and non-essential elements in eastern North Pacific killer whales (Orcinus orca).,2026,10.1371/journal.pone.0353196,https://pubmed.ncbi.nlm.nih.gov/42455828/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,41189662,Comprehensive Analysis Reveals Biomarkers Related to Diabetic Peripheral Neuropathy and Its Molecular Mechanism.,2025,10.2147/ijgm.s544464,https://pubmed.ncbi.nlm.nih.gov/41189662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,42068506,Evaluating different scoring algorithms to assess communication ability for individuals living with Angelman syndrome: the Observer-Reported Communication Ability (ORCA) measure.,2026,10.1186/s41687-026-01072-7,https://pubmed.ncbi.nlm.nih.gov/42068506/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,42038776,Association of Circular RNAs with Sperm Fertility Potential: Implications for Male Infertility Diagnosis.,2025,10.18502/jri.v26i4.21087,https://pubmed.ncbi.nlm.nih.gov/42038776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,38385979,MicroRNA-320a enhances LRWD1 expression through the AGO2/FXR1-dependent pathway to affect cell behaviors and the oxidative stress response in human testicular embryonic carcinoma cells.,2024,10.18632/aging.205571,https://pubmed.ncbi.nlm.nih.gov/38385979/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,41897885,"Variations in Circulating Thyroid Hormone Profiles Across Age, Sex, and Pregnancy Outcomes in Killer Whales (&lt;i&gt;Orcinus orca&lt;/i&gt;) Under Human Care.",2026,10.3390/ani16060907,https://pubmed.ncbi.nlm.nih.gov/41897885/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,41575710,Association of the Observer-Reported Communication Ability (ORCA) Measure with Established Communication Measures: Insights From the Angelman Syndrome Natural History Study.,2026,10.1007/s10803-026-07224-4,https://pubmed.ncbi.nlm.nih.gov/41575710/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,42622323,A Multilevel Modeling Strategy Using GULP-ORCA Integration for Crystalline Materials.,2026,10.1021/acs.jpca.6c03901,https://pubmed.ncbi.nlm.nih.gov/42622323/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,41740652,Caregiver Meaningful Score Differences and Meaningful Score Regions for the Observer-Reported Communication Ability Measure for Individuals with Angelman Syndrome.,2026,10.1016/j.jval.2026.02.002,https://pubmed.ncbi.nlm.nih.gov/41740652/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,41218715,"Kidney Function after Hematopoietic Cell Transplantation with Orca-T, Cyclophosphamide, or Methotrexate Graft-Versus-Host Disease Prophylaxis: A Single-Center Retrospective Study.",2026,10.1016/j.jtct.2025.11.005,https://pubmed.ncbi.nlm.nih.gov/41218715/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,42753097,Orca-T: First Approval.,2026,10.1007/s40291-026-00882-1,https://pubmed.ncbi.nlm.nih.gov/42753097/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,42806776,Cost-effectiveness of Orca-T vs allo-HCT with conventional GVHD prophylaxis for the treatment of advanced hematologic malignancies in the United States.,2026,10.1080/13696998.2026.2732644,https://pubmed.ncbi.nlm.nih.gov/42806776/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,42628650,Observational Comparison of Overall Survival between Phase 1b Orca-T and Registry-Based Post-Transplant Cyclophosphamide Patients.,2026,10.1016/j.jtct.2026.08.037,https://pubmed.ncbi.nlm.nih.gov/42628650/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,42180667,Comparative Effectiveness of Cytisinicline and Varenicline for Smoking Cessation: A Matching-Adjusted Indirect Comparison (MAIC).,2026,10.36469/001c.160017,https://pubmed.ncbi.nlm.nih.gov/42180667/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,41928340,Clinical and translational advances in regulatory T cell-based strategies in allogeneic hematopoietic stem cell transplantation: highlights from ASH 2025.,2026,10.1186/s40164-026-00769-1,https://pubmed.ncbi.nlm.nih.gov/41928340/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,40962497,Cytisinicline for smoking cessation in individuals with self-reported COPD: a post hoc analysis of the ORCA-2 and ORCA-3 trials.,2026,10.1136/thorax-2025-223880,https://pubmed.ncbi.nlm.nih.gov/40962497/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,40716436,Future Directions in Allogeneic Stem Cell Transplantation in Acute Lymphoblastic Leukemia.,2026,10.1159/000547644,https://pubmed.ncbi.nlm.nih.gov/40716436/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,42437374,Improving interprofessional collaboration for palliative primary care teams: results from the Canada-wide CAPACITI randomized controlled trial.,2026,10.1080/13561820.2026.2698726,https://pubmed.ncbi.nlm.nih.gov/42437374/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,42567753,SOHO State of the Art Updates and Next Questions | Best of Stem Cell Transplant: Recent Advances in Allogeneic Hematopoietic Cell Transplantation.,2026,10.1016/j.clml.2026.07.006,https://pubmed.ncbi.nlm.nih.gov/42567753/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,42536219,"Agrochemical residues and food safety: In-depth in silico assessment of the degradation mechanism of chlorpyrifos-oxon by niobium dioxide (NbO₂), a naturally occurring and cost-effective mineral.",2026,10.1007/s00894-026-06865-7,https://pubmed.ncbi.nlm.nih.gov/42536219/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,39465349,"Causal associations of MICB, CTSA, and MMP9 proteins with oral cancer: Mendelian randomization study.",2024,10.1038/s41598-024-77042-0,https://pubmed.ncbi.nlm.nih.gov/39465349/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,42590458,Teardrop Risk Field-Based Spatiotemporal Path Planning Method for Mobile Robots in Dynamic Environments.,2026,10.3390/s26154681,https://pubmed.ncbi.nlm.nih.gov/42590458/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LRWD1,ENSG00000161036,Unsafe,17074343,Identification of ten novel genes involved in human spermatogenesis by microarray analysis of testicular tissue.,2006,10.1016/j.fertnstert.2006.04.039,https://pubmed.ncbi.nlm.nih.gov/17074343/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,42337485,Integrated pan-cancer multi-omics profiling and experimental validation identify LSM12 as a prognostic biomarker and candidate therapeutic target in human cancers.,2026,10.1186/s12885-026-16258-x,https://pubmed.ncbi.nlm.nih.gov/42337485/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,40425760,LSM12 promotes the lung squamous cell carcinoma progression through mediating alternative splicing of ARRB1.,2025,10.1038/s42003-025-08193-7,https://pubmed.ncbi.nlm.nih.gov/40425760/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,41080638,Functional characterization of LSM12 as a driver in uveal melanoma oncogenesis.,2025,10.1016/j.aopr.2025.09.001,https://pubmed.ncbi.nlm.nih.gov/41080638/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,41171827,Construction of a prognostic prediction model for concurrent radiotherapy in cervical cancer using GEO and TCGA databases with preliminary validation analysis.,2025,10.1371/journal.pone.0334281,https://pubmed.ncbi.nlm.nih.gov/41171827/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,41637037,Genome-wide CRISPR/Cas9 knockout screen identifies host factors essential for bovine parainfluenza virus type 3 replication.,2026,10.1007/s11427-025-3142-x,https://pubmed.ncbi.nlm.nih.gov/41637037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,35449073,Identification of RNA-splicing factor Lsm12 as a novel tumor-associated gene and a potent biomarker in Oral Squamous Cell Carcinoma (OSCC).,2022,10.1186/s13046-022-02355-9,https://pubmed.ncbi.nlm.nih.gov/35449073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,37303493,LSM12 facilitates the progression of colorectal cancer by activating the WNT/CTNNB1 signaling pathway.,2022,10.32604/or.2022.028225,https://pubmed.ncbi.nlm.nih.gov/37303493/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,37607218,Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12.,2023,10.1126/scisignal.adg0485,https://pubmed.ncbi.nlm.nih.gov/37607218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,36095303,First description of the t(3;17)(q27;q21)/IGF2BP2::LSM12 translocation in marginal zone lymphoma.,2023,10.1182/bloodadvances.2022008393,https://pubmed.ncbi.nlm.nih.gov/36095303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,35646684,Identification of LSM Family Members as Novel Unfavorable Biomarkers in Hepatocellular Carcinoma.,2022,10.3389/fonc.2022.871771,https://pubmed.ncbi.nlm.nih.gov/35646684/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,40220918,"ATXN2L primarily interacts with NUFIP2, the absence of ATXN2L results in NUFIP2 depletion, and the ATXN2-polyQ expansion triggers NUFIP2 accumulation.",2025,10.1016/j.nbd.2025.106903,https://pubmed.ncbi.nlm.nih.gov/40220918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,34950443,"Potential Prognosis and Diagnostic Value of AKT3, LSM12, MEF2C, and RAB30 in Exosomes in Colorectal Cancer on Spark Framework.",2021,10.1155/2021/8218043,https://pubmed.ncbi.nlm.nih.gov/34950443/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,33362237,LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient.,2020,10.1371/journal.pbio.3001002,https://pubmed.ncbi.nlm.nih.gov/33362237/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,34362892,Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles.,2021,10.1038/s41467-021-24735-z,https://pubmed.ncbi.nlm.nih.gov/34362892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,34810081,NAADP-binding proteins find their identity.,2022,10.1016/j.tibs.2021.10.008,https://pubmed.ncbi.nlm.nih.gov/34810081/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,36371223,Expression profile and prognostic values of LSM family in skin cutaneous melanoma.,2022,10.1186/s12920-022-01395-6,https://pubmed.ncbi.nlm.nih.gov/36371223/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,35561646,Diversity of two-pore channels and the accessory NAADP receptors in intracellular Ca2+ signaling.,2022,10.1016/j.ceca.2022.102594,https://pubmed.ncbi.nlm.nih.gov/35561646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,30366994,Lsm12 Mediates Deubiquitination of DNA Polymerase η To Help Saccharomyces cerevisiae Resist Oxidative Stress.,2019,10.1128/aem.01988-18,https://pubmed.ncbi.nlm.nih.gov/30366994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,32532821,The RNA-associated proteins MKT1 and MKT1L form alternative PBP1-containing complexes in Trypanosoma brucei.,2020,10.1074/jbc.ra120.013306,https://pubmed.ncbi.nlm.nih.gov/32532821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,33584809,Construction of an RNA-Binding Protein-Related Prognostic Model for Pancreatic Adenocarcinoma Based on TCGA and GTEx Databases.,2020,10.3389/fgene.2020.610350,https://pubmed.ncbi.nlm.nih.gov/33584809/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,42224927,JPT2/HN1L functions as an NAADP-binding protein in a cell-type-specific manner.,2026,10.1016/j.ceca.2026.103156,https://pubmed.ncbi.nlm.nih.gov/42224927/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,39431792,Imaging Initial Ca2+ Microdomains in Primary T Cells.,2024,10.3791/67075,https://pubmed.ncbi.nlm.nih.gov/39431792/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,39514105,Use of antibodies against Epstein-Barr virus nuclear antigen 1 for detection of cellular proteins with monomethylated arginine residues that are potentially involved in viral transformation.,2024,10.1007/s00705-024-06172-7,https://pubmed.ncbi.nlm.nih.gov/39514105/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,36443544,NAADP-Evoked Ca2+ Signaling: The DUOX2-HN1L/JPT2-Ryanodine Receptor 1 Axis.,2023,10.1007/164_2022_623,https://pubmed.ncbi.nlm.nih.gov/36443544/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LSM12,ENSG00000161654,Unsafe,33054725,Clinical characteristics and prognostic implications of BRCA-associated tumors in males: a pan-tumor survey.,2020,10.1186/s12885-020-07481-1,https://pubmed.ncbi.nlm.nih.gov/33054725/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,42351767,Unveiling the Importance of the Expression of LY6/UPAR Gene Family Members in Urothelial Carcinoma of the Urinary Bladder.,2026,10.3390/biomedicines14061339,https://pubmed.ncbi.nlm.nih.gov/42351767/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,41009820,Nodal Spread Prediction in Human Oral Tongue Squamous Cell Carcinoma Using a Cancer-Testis Antigen Genes Signature.,2025,10.3390/ijms26189258,https://pubmed.ncbi.nlm.nih.gov/41009820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,39727968,Silencing LY6K Suppresses CD44+ EpCAM+ HCT116 Human Colon Cancer Stem Cells Growth: Insights from In Vitro and In Vivo Evidence.,2024,10.3390/cimb46120840,https://pubmed.ncbi.nlm.nih.gov/39727968/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,41454405,Long non-coding RNAs in the tumor immune microenvironment of non-small cell lung cancer: mechanisms and clinical translational perspectives.,2025,10.1186/s12967-025-07625-6,https://pubmed.ncbi.nlm.nih.gov/41454405/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,37141412,Human LY6 gene family: potential tumor-associated antigens and biomarkers of prognosis in uterine corpus endometrial carcinoma.,2023,10.18632/oncotarget.28409,https://pubmed.ncbi.nlm.nih.gov/37141412/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,36768616,Target Selection for T-Cell Therapy in Epithelial Ovarian Cancer: Systematic Prioritization of Self-Antigens.,2023,10.3390/ijms24032292,https://pubmed.ncbi.nlm.nih.gov/36768616/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,38469708,Upregulation of LY6K induced by FTO-mediated demethylation promotes the tumorigenesis and metastasis of oral squamous cell carcinoma via CAV-1-mediated ERK1/2 signaling activation.,2024,10.14670/hh-18-725,https://pubmed.ncbi.nlm.nih.gov/38469708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,37076981,LY6K depletion modulates TGF-β and EGF signaling.,2023,10.1002/cam4.5940,https://pubmed.ncbi.nlm.nih.gov/37076981/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,37628960,Experimental and Computational Studies Reveal Novel Interaction of Lymphocytes Antigen 6K to TGF-β Receptor Complex.,2023,10.3390/ijms241612779,https://pubmed.ncbi.nlm.nih.gov/37628960/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,36805500,"Lymphocyte antigen 6K signaling to aurora kinase promotes advancement of the cell cycle and the growth of cancer cells, which is inhibited by LY6K-NSC243928 interaction.",2023,10.1016/j.canlet.2023.216094,https://pubmed.ncbi.nlm.nih.gov/36805500/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,35242871,A narrative review of the emerging role of lymphocyte antigen 6 complex locus K in cancer: from basic research to clinical practice.,2022,10.21037/atm-21-5831,https://pubmed.ncbi.nlm.nih.gov/35242871/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,35774118,A Role of the TEX101 Interactome in the Common Aetiology Behind Male Subfertility and Testicular Germ Cell Tumor.,2022,10.3389/fonc.2022.892043,https://pubmed.ncbi.nlm.nih.gov/35774118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,32055849,LY6K promotes glioblastoma tumorigenicity via CAV-1-mediated ERK1/2 signaling enhancement.,2020,10.1093/neuonc/noaa032,https://pubmed.ncbi.nlm.nih.gov/32055849/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,33860139,Prognostic impact of LY6K and CDCA1 expression for patients with esophageal squamous cell carcinoma.,2021,10.1002/ags3.12415,https://pubmed.ncbi.nlm.nih.gov/33860139/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,34980214,Down-regulation of ZNF252P-AS1 alleviates ovarian cancer progression by binding miR-324-3p to downregulate LY6K.,2022,10.1186/s13048-021-00933-7,https://pubmed.ncbi.nlm.nih.gov/34980214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,36680947,Development of fluorophore labeled or biotinylated anticancer small molecule NSC243928.,2023,10.1016/j.bmc.2023.117171,https://pubmed.ncbi.nlm.nih.gov/36680947/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,39300449,The role of KRT7 in metastasis and prognosis of pancreatic cancer.,2024,10.1186/s12935-024-03500-4,https://pubmed.ncbi.nlm.nih.gov/39300449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,32098321,Small Molecule Binds with Lymphocyte Antigen 6K to Induce Cancer Cell Death.,2020,10.3390/cancers12020509,https://pubmed.ncbi.nlm.nih.gov/32098321/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,38356711,Aspartate β-hydroxylase Regulates Expression of Ly6 Genes.,2024,10.7150/jca.90422,https://pubmed.ncbi.nlm.nih.gov/38356711/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,39797413,"Construction of a novel radioresistance-related signature for prediction of prognosis, immune microenvironment and anti-tumour drug sensitivity in non-small cell lung cancer.",2025,10.1080/07853890.2024.2447930,https://pubmed.ncbi.nlm.nih.gov/39797413/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,30791546,A Pilot Study of Vaccine Therapy with Multiple Glioma Oncoantigen/Glioma Angiogenesis-Associated Antigen Peptides for Patients with Recurrent/Progressive High-Grade Glioma.,2019,10.3390/jcm8020263,https://pubmed.ncbi.nlm.nih.gov/30791546/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,36900259,NSC243928 Treatment Induces Anti-Tumor Immune Response in Mouse Mammary Tumor Models.,2023,10.3390/cancers15051468,https://pubmed.ncbi.nlm.nih.gov/36900259/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,25340007,Identification of immunogenic LY6K long peptide encompassing both CD4+ and CD8+ T-cell epitopes and eliciting CD4+ T-cell immunity in patients with malignant disease.,2014,10.4161/onci.28100,https://pubmed.ncbi.nlm.nih.gov/25340007/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,30655778,Transgenic overexpression of human LY6K in mice suppresses mature T cell development in the thymus.,2019,10.3892/ol.2018.9548,https://pubmed.ncbi.nlm.nih.gov/30655778/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,23613128,Phase I clinical trial of vaccination with LY6K-derived peptide in patients with advanced gastric cancer.,2014,10.1007/s10120-013-0258-6,https://pubmed.ncbi.nlm.nih.gov/23613128/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,18089789,Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas.,2007,10.1158/0008-5472.can-07-3243,https://pubmed.ncbi.nlm.nih.gov/18089789/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
LY6K,ENSG00000160886,Unsafe,12516096,"Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma.",2003,10.1002/ijc.10903,https://pubmed.ncbi.nlm.nih.gov/12516096/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,42671480,A Western-style diet exacerbates male infertility in M1ap knockout mice.,2026,10.1093/humrep/deag130,https://pubmed.ncbi.nlm.nih.gov/42671480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,42324855,Variants in ZZS Complex-Associated Genes TEX11 and M1AP Are Responsible for Male Infertility and Nonobstructive Azoospermia.,2026,10.1111/andr.70291,https://pubmed.ncbi.nlm.nih.gov/42324855/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,40374915,Genotype-specific differences in infertile men due to loss-of-function variants in M1AP or ZZS genes.,2025,10.1038/s44321-025-00244-0,https://pubmed.ncbi.nlm.nih.gov/40374915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,38073178,"Genome sequencing of Pakistani families with male infertility identifies deleterious genotypes in SPAG6, CCDC9, TKTL1, TUBA3C, and M1AP.",2025,10.1111/andr.13570,https://pubmed.ncbi.nlm.nih.gov/38073178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,40204913,S100PBP interacts with nucleoporin TPR and facilitates XY crossover formation in mice.,2025,10.1038/s44319-025-00391-y,https://pubmed.ncbi.nlm.nih.gov/40204913/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,36440627,M1AP interacts with the mammalian ZZS complex and promotes male meiotic recombination.,2023,10.15252/embr.202255778,https://pubmed.ncbi.nlm.nih.gov/36440627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,41401169,Diagnostic yield of exome sequencing in nonobstructive azoospermia (NOA): A systematic review and meta-analysis.,2025,10.1371/journal.pone.0338892,https://pubmed.ncbi.nlm.nih.gov/41401169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,32673564,Bi-allelic Mutations in M1AP Are a Frequent Cause of Meiotic Arrest and Severely Impaired Spermatogenesis Leading to Male Infertility.,2020,10.1016/j.ajhg.2020.06.010,https://pubmed.ncbi.nlm.nih.gov/32673564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,40207873,Placental transcriptomic profiling in a mouse model of fetal growth restriction reveals disturbed inflammation and immunity regulation†.,2025,10.1093/biolre/ioaf083,https://pubmed.ncbi.nlm.nih.gov/40207873/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,36230452,F1 Male Sterility in Cattle-Yak Examined through Changes in Testis Tissue and Transcriptome Profiles.,2022,10.3390/ani12192711,https://pubmed.ncbi.nlm.nih.gov/36230452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,37459509,In vivo versus in silico assessment of potentially pathogenic missense variants in human reproductive genes.,2023,10.1073/pnas.2219925120,https://pubmed.ncbi.nlm.nih.gov/37459509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,35341049,Structural analysis of M1AP variants associated with severely impaired spermatogenesis causing male infertility.,2022,10.7717/peerj.12947,https://pubmed.ncbi.nlm.nih.gov/35341049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,40176181,Modified screening of MYC promotor region elements using the CRISPR library in ovarian cancer.,2025,10.1186/s13048-025-01644-z,https://pubmed.ncbi.nlm.nih.gov/40176181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,39325344,Unraveling the mysteries of early embryonic arrest: genetic factors and molecular mechanisms.,2024,10.1007/s10815-024-03259-7,https://pubmed.ncbi.nlm.nih.gov/39325344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,34604049,Genetic Variants of CLPP and M1AP Are Associated With Risk of Non-Small Cell Lung Cancer.,2021,10.3389/fonc.2021.709829,https://pubmed.ncbi.nlm.nih.gov/34604049/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,32411526,CRISPR screening identifies M1AP as a new MYC regulator with a promoter-reporter system.,2020,10.7717/peerj.9046,https://pubmed.ncbi.nlm.nih.gov/32411526/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,32017041,An M1AP homozygous splice-site mutation associated with severe oligozoospermia in a consanguineous family.,2020,10.1111/cge.13712,https://pubmed.ncbi.nlm.nih.gov/32017041/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,23269666,Meiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (M1ap)-deficient mice.,2013,10.1095/biolreprod.111.098673,https://pubmed.ncbi.nlm.nih.gov/23269666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,36265781,A more novel and robust gene signature predicts outcome in patients with esophageal squamous cell carcinoma.,2022,10.1016/j.clinre.2022.102033,https://pubmed.ncbi.nlm.nih.gov/36265781/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
M1AP,ENSG00000159374,Unsafe,27008852,Identification of Genes That Modulate Susceptibility to Formaldehyde and Imatinib by Functional Genomic Screening in Human Haploid KBM7 Cells.,2016,10.1093/toxsci/kfw032,https://pubmed.ncbi.nlm.nih.gov/27008852/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,42625859,"Dysregulation of piRNA biogenesis-associated proteins in cancer: mechanisms, evidence, and translational constraints.",2026,10.3389/fmolb.2026.1906635,https://pubmed.ncbi.nlm.nih.gov/42625859/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,42156581,"Vorinostat unmasks MAEL to enhance DC vaccine-induced CTL killing in hepatocellular carcinoma, potentiated by TIGIT checkpoint inhibition.",2026,10.1007/s00262-026-04410-2,https://pubmed.ncbi.nlm.nih.gov/42156581/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,41831546,"Integrative genomics elucidates the evolutionary, temporal, and developmental origins of a hydrocephalus risk gene.",2026,10.1016/j.expneurol.2026.115725,https://pubmed.ncbi.nlm.nih.gov/41831546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,42765852,RETRACTION: MAEL Expression Links Epithelial-Mesenchymal Transition and Stem Cell Properties in Colorectal Cancer.,2026,10.1002/ijc.70739,https://pubmed.ncbi.nlm.nih.gov/42765852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,38301040,MAEL in human cancers and implications in prognostication and predicting benefit from immunotherapy over VEGFR/mTOR inhibitors in clear cell renal cell carcinoma: a bioinformatic analysis.,2024,10.18632/aging.205470,https://pubmed.ncbi.nlm.nih.gov/38301040/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,39987352,Insights into the role of hnRNPK in spermatogenesis via the piRNA pathway.,2025,10.1038/s41598-025-91081-1,https://pubmed.ncbi.nlm.nih.gov/39987352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,40442410,Genetic and functional analysis reveals novel mutations in meiotic genes underlying non-obstructive azoospermia.,2025,10.1007/s10815-025-03505-6,https://pubmed.ncbi.nlm.nih.gov/40442410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,39331689,Loss-of-function variant in TDRD6 cause male infertility with severe oligo-astheno-teratozoospermia in human and mice.,2024,10.1111/jcmm.18580,https://pubmed.ncbi.nlm.nih.gov/39331689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,36711243,MAEL gene contributes to bovine testicular development through the m5C-mediated splicing.,2023,10.1016/j.isci.2023.105941,https://pubmed.ncbi.nlm.nih.gov/36711243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,39122675,"Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertility.",2024,10.1038/s41467-024-50930-9,https://pubmed.ncbi.nlm.nih.gov/39122675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,36779514,The MAEL expression in mitochondria of human spermatozoa and the association with asthenozoospermia.,2023,10.1111/andr.13408,https://pubmed.ncbi.nlm.nih.gov/36779514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,39874134,A Comprehensive Evaluation of the Neuropharmacological Potential of Methanolic Leaf Extract of Acanthus ebracteatus (Vahl.) Using Experimental and In Silico Approaches.,2025,10.1002/cbdv.202402250,https://pubmed.ncbi.nlm.nih.gov/39874134/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,42510227,Psychometric Evaluation of the Identification with the Country Scale in a Chilean Sample.,2026,10.3390/bs16071106,https://pubmed.ncbi.nlm.nih.gov/42510227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,36476246,Morphine suppresses the immune function of lung cancer by up-regulating MAEL expression.,2022,10.1186/s40360-022-00632-z,https://pubmed.ncbi.nlm.nih.gov/36476246/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,41113352,Time-series transcriptomics and alternative splicing analysis of embryonic development of the asian honeybee (&lt;i&gt;Apis cerana&lt;/i&gt;).,2025,10.3389/fgene.2025.1665548,https://pubmed.ncbi.nlm.nih.gov/41113352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,35740546,MAEL Augments Cancer Stemness Properties and Resistance to Sorafenib in Hepatocellular Carcinoma through the PTGS2/AKT/STAT3 Axis.,2022,10.3390/cancers14122880,https://pubmed.ncbi.nlm.nih.gov/35740546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,33902648,MAEL as a diagnostic marker for the early detection of esophageal squamous cell carcinoma.,2021,10.1186/s13000-021-01098-z,https://pubmed.ncbi.nlm.nih.gov/33902648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,36866961,MAEL facilitates metabolic reprogramming and breast cancer progression by promoting the degradation of citrate synthase and fumarate hydratase via chaperone-mediated autophagy.,2023,10.1111/febs.16768,https://pubmed.ncbi.nlm.nih.gov/36866961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,35513870,Maelstrom promotes tumor metastasis through regulation of FGFR4 and epithelial-mesenchymal transition in epithelial ovarian cancer.,2022,10.1186/s13048-022-00992-4,https://pubmed.ncbi.nlm.nih.gov/35513870/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,35488386,Identification of MAEL as a promoter for the drug resistance model of iPSCs derived from T-ALL.,2022,10.1002/cam4.4712,https://pubmed.ncbi.nlm.nih.gov/35488386/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,42059094,The Impact of Mushroom Management on Nurses' Job Satisfaction: The Mediating Role of Organizational Identification.,2026,10.1155/jonm/8888440,https://pubmed.ncbi.nlm.nih.gov/42059094/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,37752345,Maximum Augmented Empirical Likelihood Estimation of Categorical Marginal Models for Large Sparse Contingency Tables.,2023,10.1007/s11336-023-09932-7,https://pubmed.ncbi.nlm.nih.gov/37752345/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,33310860,Piwi suppresses transcription of Brahma-dependent transposons via Maelstrom in ovarian somatic cells.,2020,10.1126/sciadv.aaz7420,https://pubmed.ncbi.nlm.nih.gov/33310860/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,32365144,Effect of ovarian stimulation on the expression of piRNA pathway proteins.,2020,10.1371/journal.pone.0232629,https://pubmed.ncbi.nlm.nih.gov/32365144/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,29371914,MAEL contributes to gastric cancer progression by promoting ILKAP degradation.,2017,10.18632/oncotarget.22970,https://pubmed.ncbi.nlm.nih.gov/29371914/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,33749163,Identification of an individualized RNA binding protein-based prognostic signature for diffuse large B-cell lymphoma.,2021,10.1002/cam4.3859,https://pubmed.ncbi.nlm.nih.gov/33749163/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,32973212,Novel targets identified by integrated proteomic and phosphoproteomic analysis in spermatogenesis of swamp buffalo (Bubalus bubalis).,2020,10.1038/s41598-020-72353-4,https://pubmed.ncbi.nlm.nih.gov/32973212/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,27597120,Tissue-specific Co-expression of Long Non-coding and Coding RNAs Associated with Breast Cancer.,2016,10.1038/srep32731,https://pubmed.ncbi.nlm.nih.gov/27597120/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,21298349,Epigenomic analysis of aberrantly methylated genes in colorectal cancer identifies genes commonly affected by epigenetic alterations.,2011,10.1245/s10434-011-1573-y,https://pubmed.ncbi.nlm.nih.gov/21298349/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,4990884,Followup of mael and female contacts of patients with gonorrhea.,1970,10.2307/4594022,https://pubmed.ncbi.nlm.nih.gov/4990884/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,69007,Selective response to H-Y antigen by F1 female mice sensitized to F1 male cells.,1977,10.1084/jem.146.2.606,https://pubmed.ncbi.nlm.nih.gov/69007/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAEL,ENSG00000143194,Unsafe,19693694,Identification of a novel human cancer/testis gene MAEL that is regulated by DNA methylation.,2010,10.1007/s11033-009-9741-x,https://pubmed.ncbi.nlm.nih.gov/19693694/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42258745,LDL receptor-mediated lipoprotein uptake fuels human CD4+ T cell polarization toward a c-MAF/IL-10- and FOXP3-driven phenotype.,2026,10.1172/jci.insight.198505,https://pubmed.ncbi.nlm.nih.gov/42258745/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42918401,MAF Transcription Factors: Emerging Key Players in Cardiovascular Health and Disease.,2026,10.1016/j.biocel.2026.107055,https://pubmed.ncbi.nlm.nih.gov/42918401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42603289,Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR-155/MafB Axis.,2026,10.1002/advs.77053,https://pubmed.ncbi.nlm.nih.gov/42603289/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,41455473,Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis.,2026,10.1016/j.immuni.2025.11.022,https://pubmed.ncbi.nlm.nih.gov/41455473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,41827001,Myeloid-derived immunosuppression of chimeric antigen receptor T cells in the neuronal microenvironment of glioblastoma.,2026,10.1186/s12916-026-04783-2,https://pubmed.ncbi.nlm.nih.gov/41827001/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42678350,GWAS of Tau-Neurodegeneration Mismatch Identifies New Risk Loci for Susceptibility to Tau.,2026,10.1002/cns.71125,https://pubmed.ncbi.nlm.nih.gov/42678350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42898638,Biological sex and disease architecture in systemic sclerosis: a multilayer translational framework for precision medicine.,2026,10.3389/fimmu.2026.1978654,https://pubmed.ncbi.nlm.nih.gov/42898638/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42309067,Roles of Metastasis Associated Fibroblasts in Paclitaxel Resistance of Brain Metastatic Tumor Cells: Evaluation in Metastatic Organoids.,2026,10.1080/07357907.2025.2596852,https://pubmed.ncbi.nlm.nih.gov/42309067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,41840659,Lipid droplet-mediated macrophage reprogramming drives fibroblast activation in keloid-associated inflammation.,2026,10.1186/s12964-026-02807-1,https://pubmed.ncbi.nlm.nih.gov/41840659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,41629569,Cerebrospinal fluid cfDNA-based molecular assessment of resection extent and prognosis in glioma.,2026,10.1038/s43856-026-01386-z,https://pubmed.ncbi.nlm.nih.gov/41629569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,41274869,Integrating whole genome and transcriptome sequencing to characterize the genetic architecture of isoform variation.,2025,10.1038/s41467-025-64336-8,https://pubmed.ncbi.nlm.nih.gov/41274869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42274008,USP5-C-MAF Axis Regulates Autophagy-Dependent Neuronal Ferroptosis in Spinal Cord Injury Therapeutics.,2026,10.1002/cns.70854,https://pubmed.ncbi.nlm.nih.gov/42274008/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42730373,Nonbacterial Thrombotic Endocarditis Unmasking Concomitant Monoclonal Gammopathy of Undetermined Significance (MGUS) by Manifesting as Stroke.,2026,10.7759/cureus.114409,https://pubmed.ncbi.nlm.nih.gov/42730373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42010059,Immunopeptidome profiling in pulmonary fibrosis provides a platform for identifying therapeutic targets.,2026,10.1038/s41590-026-02501-x,https://pubmed.ncbi.nlm.nih.gov/42010059/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42620748,GFI1 as a novel regulator of γδ T cell development and the IL-17/IFN-γ lineage commitment.,2026,10.3389/fimmu.2026.1849622,https://pubmed.ncbi.nlm.nih.gov/42620748/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42577896,TCR γδ cell-specific STAT5 gain of function induces a druggable chronic human immune dysregulation.,2026,10.70962/jhi.20250175,https://pubmed.ncbi.nlm.nih.gov/42577896/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42564280,DBENet: Dual-Branch Encoder Network for brain MRI lesion segmentation.,2026,10.3389/fneur.2026.1766271,https://pubmed.ncbi.nlm.nih.gov/42564280/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42861729,Assessment of accommodative function in individuals aged 40-50 years with stage 1 hypertension without hypertensive retinopathy compared with age-matched healthy controls.,2026,10.1080/09273972.2026.2746560,https://pubmed.ncbi.nlm.nih.gov/42861729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42424313,Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis.,2026,10.1084/jem.20252236,https://pubmed.ncbi.nlm.nih.gov/42424313/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42414212,"c-Maf Deletion in Cortical Somatostatin, But Not Parvalbumin, Interneurons Leads to Absence-Like Epileptiform Activity in Mice.",2026,10.1523/eneuro.0257-25.2026,https://pubmed.ncbi.nlm.nih.gov/42414212/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42418224,"Belantamab mafodotin, a BCMA-directed antibody-drug conjugate for multiple myeloma.",2026,10.1080/14796694.2026.2700028,https://pubmed.ncbi.nlm.nih.gov/42418224/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42649924,Anti-PD-1 Treatment Restores Effector Function in Exhausted-like T Cells from Malignant Ascites of Ovarian Cancer Patients.,2026,10.3390/cancers18162612,https://pubmed.ncbi.nlm.nih.gov/42649924/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42631848,Carambola-like metal-AIEgen framework-based fluorescent lateral flow assay for the sensitive detection of zearalenone.,2026,10.1007/s00604-026-08358-z,https://pubmed.ncbi.nlm.nih.gov/42631848/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42193030,"Elevated Allele Frequency of a Common Germline &lt;i&gt;LAG3&lt;/i&gt; Variant Associated with Anemia, Thrombocytopenia and Peripheral Blast Percentage in Acute Myeloid Leukemia.",2026,10.3390/cancers18101671,https://pubmed.ncbi.nlm.nih.gov/42193030/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42430483,"Epigenetic landscape, key transcriptional regulators, and in vivo identification of human Tr1 cells.",2026,10.1126/sciadv.aec6358,https://pubmed.ncbi.nlm.nih.gov/42430483/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42875418,On-demand design of controlled-release systems using an expert-mimic AI framework.,2026,10.1038/s41467-026-77619-5,https://pubmed.ncbi.nlm.nih.gov/42875418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42548792,Pharmacogenomic variation and chemotherapy-related toxicity profiles in pediatric patients with cancer in Tanzania: a cross-sectional study.,2026,10.3389/fphar.2026.1886874,https://pubmed.ncbi.nlm.nih.gov/42548792/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42669144,Prevalence and clinical impact of the uncommon DPYD c.257C&gt;T (Pro86Leu) variant in a multiethnic cohort receiving fluoropyrimidine therapy.,2026,10.1097/fpc.0000000000000616,https://pubmed.ncbi.nlm.nih.gov/42669144/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,41383619,Transcription factor c-Maf: a checkpoint that programs autoimmunity.,2025,10.3389/fimmu.2025.1682098,https://pubmed.ncbi.nlm.nih.gov/41383619/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42500775,A Rare Case of Plasmablastic Myeloma With Dual Kappa and Lambda mRNA Expression Presenting as a Solitary Hard Palate Tumor.,2026,10.7759/cureus.111446,https://pubmed.ncbi.nlm.nih.gov/42500775/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,41728848,Targeting Melanoma-Associated Fibroblasts to Overcome Cancer Stem Cell-Driven Drug Resistance.,2026,10.1097/xcs.0000000000001752,https://pubmed.ncbi.nlm.nih.gov/41728848/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,41578711,A Novel MAF Variant Causing Aymé-Gripp Syndrome With Transient Anemia.,2026,10.1002/cga.70042,https://pubmed.ncbi.nlm.nih.gov/41578711/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42024100,Whole genome sequencing analysis of over 3500 individuals dementia-free over 85 years old.,2026,10.1177/13872877261444302,https://pubmed.ncbi.nlm.nih.gov/42024100/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,42329750,DPYD polymorphisms in Native populations from the Brazilian Amazon: the absence of the variants in currently recommended clinical genotyping panels.,2026,10.1097/fpc.0000000000000611,https://pubmed.ncbi.nlm.nih.gov/42329750/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAF,ENSG00000178573,Unsafe,17897790,CD13/APN transcription is regulated by the proto-oncogene c-Maf via an atypical response element.,2007,10.1016/j.gene.2007.08.010,https://pubmed.ncbi.nlm.nih.gov/17897790/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,41387877,Tumor immune microenvironment score predicts efficacy of immune checkpoint inhibitors-based regimens in advanced non-small cell lung cancer.,2025,10.1186/s12967-025-07408-z,https://pubmed.ncbi.nlm.nih.gov/41387877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,33284140,Re-examination of MAGE-A3 as a T-cell Therapeutic Target.,2021,10.1097/cji.0000000000000348,https://pubmed.ncbi.nlm.nih.gov/33284140/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,34202157,Epigenetic Upregulation of MAGE-A Isoforms Promotes Breast Cancer Cell Aggressiveness.,2021,10.3390/cancers13133176,https://pubmed.ncbi.nlm.nih.gov/34202157/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,40317152,Restricted cubic spline analysis: Age-dependent relationship between MAGEA12 and hepatocellular carcinoma prognosis.,2025,10.4103/jcrt.jcrt_1690_24,https://pubmed.ncbi.nlm.nih.gov/40317152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,34085601,Resveratrol acts via melanoma-associated antigen A12 (MAGEA12)/protein kinase B (Akt) signaling to inhibit the proliferation of oral squamous cell carcinoma cells.,2021,10.1080/21655979.2021.1934242,https://pubmed.ncbi.nlm.nih.gov/34085601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,37866309,Diagnostic performance of anti-MAGEA family protein autoantibodies in esophageal squamous cell carcinoma.,2023,10.1016/j.intimp.2023.111041,https://pubmed.ncbi.nlm.nih.gov/37866309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,38588631,Identification and validation of regulatory T cell-associated gene signatures to predict colon adenocarcinoma prognosis.,2024,10.1016/j.intimp.2024.112034,https://pubmed.ncbi.nlm.nih.gov/38588631/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,28978129,Melanoma antigen A12 regulates cell cycle via tumor suppressor p21 expression.,2017,10.18632/oncotarget.19497,https://pubmed.ncbi.nlm.nih.gov/28978129/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,30615012,Expression of cancer/testis antigens in cutaneous melanoma: a systematic review.,2019,10.1097/cmr.0000000000000569,https://pubmed.ncbi.nlm.nih.gov/30615012/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,30952725,Overexpression and Implications of Melanoma-associated Antigen A12 in Pathogenesis of Human Cutaneous Squamous Cell Carcinoma.,2019,10.21873/anticanres.13292,https://pubmed.ncbi.nlm.nih.gov/30952725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,33931137,Immunological and functional aspects of MAGEA3 cancer/testis antigen.,2021,10.1016/bs.apcsb.2020.08.001,https://pubmed.ncbi.nlm.nih.gov/33931137/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,37535601,"TGM2, HMGA2, FXYD3, and LGALS4 genes as biomarkers in acquired oxaliplatin resistance of human colorectal cancer: A systems biology approach.",2023,10.1371/journal.pone.0289535,https://pubmed.ncbi.nlm.nih.gov/37535601/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,25316266,Melanoma-associated antigen genes: a new trend to predict the prognosis of breast cancer patients.,2014,10.1007/s12032-014-0285-0,https://pubmed.ncbi.nlm.nih.gov/25316266/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,25120790,Expression and clinical significance of cancer-testis genes in clear cell renal cell carcinoma.,2014,,https://pubmed.ncbi.nlm.nih.gov/25120790/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,35126454,A Prognostic Model Based on Nine DNA Methylation-Driven Genes Predicts Overall Survival for Colorectal Cancer.,2021,10.3389/fgene.2021.779383,https://pubmed.ncbi.nlm.nih.gov/35126454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,35142951,Differential gene expression and network analysis in head and neck squamous cell carcinoma.,2022,10.1007/s11010-022-04379-3,https://pubmed.ncbi.nlm.nih.gov/35142951/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,18057533,Expression of MAGE-A12 in oral squamous cell carcinoma.,2008,10.1155/2008/359840,https://pubmed.ncbi.nlm.nih.gov/18057533/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,28043151,Identification of MAGEA12 as a prognostic outlier gene in gastric cancers.,2017,10.4149/neo_2017_210,https://pubmed.ncbi.nlm.nih.gov/28043151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,23090077,Characterization of T-cell receptors directed against HLA-A*01-restricted and C*07-restricted epitopes of MAGE-A3 and MAGE-A12.,2012,10.1097/cji.0b013e31827338ea,https://pubmed.ncbi.nlm.nih.gov/23090077/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,35622212,Identification of a seven-gene signature predicting clinical outcome of liver cancer based on tumor mutational burden.,2022,10.1007/s13577-022-00708-2,https://pubmed.ncbi.nlm.nih.gov/35622212/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,27323861,Expression of tumor antigens on primary ovarian cancer cells compared to established ovarian cancer cell lines.,2016,10.18632/oncotarget.10028,https://pubmed.ncbi.nlm.nih.gov/27323861/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,23377668,Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy.,2013,10.1097/cji.0b013e3182829903,https://pubmed.ncbi.nlm.nih.gov/23377668/,therapy,Discussed in explicit gene adjudication; see its review depth and limitations
MAGEA12,ENSG00000213401,Unsafe,22707303,Identification of novel MAGE-A6- and MAGE-A12-derived HLA-A24-restricted cytotoxic T lymphocyte epitopes using an in silico peptide-docking assay.,2012,10.1007/s00262-012-1298-1,https://pubmed.ncbi.nlm.nih.gov/22707303/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,21149604,A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer.,2011,10.4049/jimmunol.1001775,https://pubmed.ncbi.nlm.nih.gov/21149604/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,12673681,Clinical and immunological evaluation of patients with metastatic melanoma undergoing immunization with the HLA-Cw*0702-associated epitope MAGE-A12:170-178.,2003,10.1002/ijc.11045,https://pubmed.ncbi.nlm.nih.gov/12673681/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,16988823,Selective identification of HLA-DP4 binding T cell epitopes encoded by the MAGE-A gene family.,2007,10.1007/s00262-006-0230-y,https://pubmed.ncbi.nlm.nih.gov/16988823/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,21396841,Expression profile of cancer-testis genes in transitional cell carcinoma of the bladder.,2012,10.1016/j.urolonc.2010.08.017,https://pubmed.ncbi.nlm.nih.gov/21396841/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,24573400,Novel cancer-testis antigen expression on glioma cell lines derived from high-grade glioma patients.,2014,10.3892/or.2014.3049,https://pubmed.ncbi.nlm.nih.gov/24573400/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA12,ENSG00000213401,Unsafe,10820289,Cytolytic T lymphocytes raised against a human bladder carcinoma recognize an antigen encoded by gene MAGE-A12.,2000,10.4049/jimmunol.164.11.6041,https://pubmed.ncbi.nlm.nih.gov/10820289/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,42755095,MAGEA Family Gene Expression Influences Survival in Intestinal-Type Gastric Cancer.,2026,10.1002/cam4.72298,https://pubmed.ncbi.nlm.nih.gov/42755095/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,41759780,Exploring high-affinity MAGE-A3-specific T-cell receptors derived from healthy donor PBMCs: A preclinical evaluation.,2026,10.1016/j.trsl.2026.02.007,https://pubmed.ncbi.nlm.nih.gov/41759780/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,41489697,Serum cancer testis antigen MAGEA3-IgG serves as a diagnostic biomarker in lung adenocarcinoma.,2026,10.1007/s12094-025-04173-9,https://pubmed.ncbi.nlm.nih.gov/41489697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,41452900,Integrated analysis of single-cell and bulk RNA-seq reveals MAGEA3/6-associated immune subtypes and key immune genes in gastric cancer.,2025,10.1371/journal.pone.0338705,https://pubmed.ncbi.nlm.nih.gov/41452900/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,40743771,MAGE-A3 as a target for cancer immunotherapy: A systematic review of clinical and preclinical evidence.,2025,10.1016/j.currproblcancer.2025.101237,https://pubmed.ncbi.nlm.nih.gov/40743771/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,42602890,Investigation and validation of prognostic features associated with transient receptor potential channel genes in gastric cancer.,2026,10.7717/peerj.21468,https://pubmed.ncbi.nlm.nih.gov/42602890/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,42041682,A Pan-Cancer Transcriptomic Signature for Conserved Molecular Programs Underlying Premalignant-Malignant Progression Across Common Carcinomas.,2026,10.3390/dj14040228,https://pubmed.ncbi.nlm.nih.gov/42041682/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,41566414,Melanoma antigen genes A1 and A3 as predictors of treatment response and survival in HCV-associated hepatocellular carcinoma: a prospective study.,2026,10.1186/s12876-025-04574-8,https://pubmed.ncbi.nlm.nih.gov/41566414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,41655433,Targeting hepatocellular carcinoma with MAGE-A3-specific TCR-engineered T cells: A therapeutic approach.,2026,10.1016/j.intimp.2026.116339,https://pubmed.ncbi.nlm.nih.gov/41655433/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,41126072,"Design, synthesis, and evaluation of A therapeutic vaccine candidate against lung cancer based on multi-epitopes of MAGE-A3, TGF-β2, and VEGF-A.",2025,10.1186/s12885-025-14950-y,https://pubmed.ncbi.nlm.nih.gov/41126072/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,41009820,Nodal Spread Prediction in Human Oral Tongue Squamous Cell Carcinoma Using a Cancer-Testis Antigen Genes Signature.,2025,10.3390/ijms26189258,https://pubmed.ncbi.nlm.nih.gov/41009820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,42509244,The Dendritic Cell-based Vaccine PROTEXI leverages Antiviral CD4 T cell Memory to boost anti-tumor immune responses in mice.,2026,10.1038/s41467-026-74891-3,https://pubmed.ncbi.nlm.nih.gov/42509244/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,40342736,Unveiling MAGEA3: a novel predictive biomarker for bevacizumab resistance in colorectal cancer.,2025,10.20517/cdr.2025.35,https://pubmed.ncbi.nlm.nih.gov/40342736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,40791813,DNA-demethylation by DAC induces &lt;i&gt;MAGE&lt;/i&gt; expression and MAGE-specific T cell reactivity against tumors but also healthy cell subsets.,2025,10.1016/j.omton.2025.201018,https://pubmed.ncbi.nlm.nih.gov/40791813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,38555374,Cancer testis antigen MAGEA3 in serum and serum-derived exosomes serves as a promising biomarker in lung adenocarcinoma.,2024,10.1038/s41598-024-58003-z,https://pubmed.ncbi.nlm.nih.gov/38555374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,39450161,Modified Dendritic cell-based T-cell expansion protocol and single-cell multi-omics allow for the selection of the most expanded and &lt;i&gt;in vitro&lt;/i&gt;-effective clonotype via profiling of thousands of MAGE-A3-specific T-cells.,2024,10.3389/fimmu.2024.1470130,https://pubmed.ncbi.nlm.nih.gov/39450161/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,42594762,iPSC-derived polyvalent vaccines as ontogenetically informed immunogens toward overcoming immune refractoriness in microsatellite-stable colorectal cancer: An emerging frontier in cancer immunotherapy.,2026,10.1016/j.molimm.2026.08.008,https://pubmed.ncbi.nlm.nih.gov/42594762/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,41175267,Computational identification of cross-reactive TCR epitopes with ARDitox.,2025,10.1007/s00432-025-06330-7,https://pubmed.ncbi.nlm.nih.gov/41175267/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,39410046,Innovative Cancer Immunotherapy with MAGE-A3 mRNA Cancer Vaccines.,2024,10.3390/cancers16193428,https://pubmed.ncbi.nlm.nih.gov/39410046/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,41173834,S100A9 enhances tumor immune suppression and cancer cell survival in small cell lung cancer.,2025,10.1038/s41419-025-08102-0,https://pubmed.ncbi.nlm.nih.gov/41173834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,41630477,A data-driven cartography of NSCLC vaccine research: Quantifying the paradigm shift toward immuno-oncology combination therapies.,2026,10.1080/21645515.2026.2615515,https://pubmed.ncbi.nlm.nih.gov/41630477/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,41002418,"Advances in Non-Small Cell Lung Cancer Cellular Immunotherapy: A Progress in Dendritic Cell, T-Cell, and NK Cell Vaccines.",2025,10.3390/cells14181453,https://pubmed.ncbi.nlm.nih.gov/41002418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,42889189,Peptide optimization to improve antigen presentation and antitumor responses in sarcoma.,2026,10.3389/fimmu.2026.1960095,https://pubmed.ncbi.nlm.nih.gov/42889189/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,41101155,"Innovative therapeutic cancer vaccine PDC&lt;sup&gt;∗&lt;/sup&gt;lung01 with or without anti-PD-1: an open-label, dose-escalation phase I/II study in non-small-cell lung cancer.",2025,10.1016/j.esmoop.2025.105844,https://pubmed.ncbi.nlm.nih.gov/41101155/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,38890171,"Expression of the tumor antigens NY-ESO-1, tyrosinase, MAGE-A3, and TPTE in pediatric and adult melanoma: a retrospective case control study.",2024,10.1007/s00428-024-03846-0,https://pubmed.ncbi.nlm.nih.gov/38890171/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,37649599,Global analysis of HLA-A2 restricted MAGE-A3 tumor antigen epitopes and corresponding TCRs in non-small cell lung cancer.,2023,10.7150/thno.84710,https://pubmed.ncbi.nlm.nih.gov/37649599/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,41730382,Reprogramming the immune microenvironment in triple-negative breast cancer with mRNA therapeutics.,2026,10.1016/j.canlet.2026.218350,https://pubmed.ncbi.nlm.nih.gov/41730382/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,40008881,Identification of immunogenic HLA-A*02:01 epitopes associated with HCC for immunotherapy development.,2025,10.1097/hc9.0000000000000659,https://pubmed.ncbi.nlm.nih.gov/40008881/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEA3,ENSG00000221867,Unsafe,8113684,Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.,1994,10.1084/jem.179.3.921,https://pubmed.ncbi.nlm.nih.gov/8113684/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,41945953,"Protein Expression of MAGEB2 in Normal Oral Mucosa, Oral Epithelial Dysplasia, and Oral Squamous Cell Carcinoma and Its Association with Clinicopathological Parameters.",2026,10.31557/apjcp.2026.27.4.1359,https://pubmed.ncbi.nlm.nih.gov/41945953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,40141091,Interplay Between TGFβ1 Signaling and Cancer-Testis Antigen MAGEB2: A New Thorn in Cancer's Side?,2025,10.3390/ijms26062448,https://pubmed.ncbi.nlm.nih.gov/40141091/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,41091706,"A survey of human cancer-germline genes: Linking X chromosome localization, DNA methylation and sex-biased expression in early embryos.",2025,10.1371/journal.pgen.1011734,https://pubmed.ncbi.nlm.nih.gov/41091706/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,37304127,MAGEB2-Mediated Degradation of EGR1 Regulates the Proliferation and Apoptosis of Human Spermatogonial Stem Cell Lines.,2023,10.1155/2023/3610466,https://pubmed.ncbi.nlm.nih.gov/37304127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,37341056,Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer.,2023,10.1002/1878-0261.13474,https://pubmed.ncbi.nlm.nih.gov/37341056/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,41544563,Genome-wide interaction analysis of long-term trihalomethane exposure in drinking water and colorectal cancer risk in a Spanish Multicenter Case-Control Study (MCC-Spain).,2026,10.1016/j.envint.2026.110059,https://pubmed.ncbi.nlm.nih.gov/41544563/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,42544649,[Establishment of a Doxorubicin-Resistant Acute Myeloid Leukemia Cell Line and Study on Its Drug Resistance Mechanisms].,2026,10.19746/j.cnki.issn1009-2137.2026.03.004,https://pubmed.ncbi.nlm.nih.gov/42544649/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,39938636,Integrating transcriptome and metabolomics analyses of hepatocellular carcinoma to discover novel biomarkers and drug targets.,2025,10.1016/j.clinre.2025.102546,https://pubmed.ncbi.nlm.nih.gov/39938636/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,36085146,ZNF276 promotes the malignant phenotype of breast carcinoma by activating the CYP1B1-mediated Wnt/β-catenin pathway.,2022,10.1038/s41419-022-05223-8,https://pubmed.ncbi.nlm.nih.gov/36085146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,35937396,Expression Profile of MAGE-B1 Gene and Its Hypomethylation Activation in Colon Cancer.,2022,10.1155/2022/6066567,https://pubmed.ncbi.nlm.nih.gov/35937396/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,38769028,Involvement of circRNA Regulators MBNL1 and QKI in the Progression of Esophageal Squamous Cell Carcinoma.,2024,10.1177/10732748241257142,https://pubmed.ncbi.nlm.nih.gov/38769028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,32692974,Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance.,2020,10.1016/j.molcel.2020.06.037,https://pubmed.ncbi.nlm.nih.gov/32692974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,35618211,Cancer germline antigen gene MAGEB2 promotes cell invasion and correlates with immune microenvironment and immunotherapeutic efficiency in laryngeal cancer.,2022,10.1016/j.clim.2022.109045,https://pubmed.ncbi.nlm.nih.gov/35618211/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,37002972,Ponicidin inhibited gallbladder cancer proliferation and metastasis by decreasing MAGEB2 expression through FOXO4.,2023,10.1016/j.phymed.2023.154785,https://pubmed.ncbi.nlm.nih.gov/37002972/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,36428603,Transcriptomic and Proteomic Profiles for Elucidating Cisplatin Resistance in Head-and-Neck Squamous Cell Carcinoma.,2022,10.3390/cancers14225511,https://pubmed.ncbi.nlm.nih.gov/36428603/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,33741433,Expression of the tumor-expressed protein MageB2 enhances rRNA transcription.,2021,10.1016/j.bbamcr.2021.119015,https://pubmed.ncbi.nlm.nih.gov/33741433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,34827627,Comprehensive Atlas of the Myelin Basic Protein Interaction Landscape.,2021,10.3390/biom11111628,https://pubmed.ncbi.nlm.nih.gov/34827627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,30006881,Specific Features of Transcription Activity of Cancer-Testis Antigens in Patients with Metastatic and Non-Metastatic Breast Cancer.,2018,10.1007/s10517-018-4175-x,https://pubmed.ncbi.nlm.nih.gov/30006881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,26642794,Aberrant demethylation and expression of MAGEB2 in a subset of malignant peripheral nerve sheath tumors from neurofibromatosis type 1.,2016,10.1016/j.jdermsci.2015.11.004,https://pubmed.ncbi.nlm.nih.gov/26642794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,33005105,Identification and validation of methylation-driven genes prognostic signature for recurrence of laryngeal squamous cell carcinoma by integrated bioinformatics analysis.,2020,10.1186/s12935-020-01567-3,https://pubmed.ncbi.nlm.nih.gov/33005105/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,35660381,Low-dose hexavalent chromium(VI) exposure promotes prostate cancer cell proliferation by activating MAGEB2-AR signal pathway.,2022,10.1016/j.ecoenv.2022.113724,https://pubmed.ncbi.nlm.nih.gov/35660381/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,30122941,Cancer/testis antigens (CTAs) expression in resected lung cancer.,2018,10.2147/ott.s159491,https://pubmed.ncbi.nlm.nih.gov/30122941/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,27563821,"AIRE polymorphism, melanoma antigen-specific T cell immunity, and susceptibility to melanoma.",2016,10.18632/oncotarget.11506,https://pubmed.ncbi.nlm.nih.gov/27563821/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,34307667,Trophinin Is an Important Biomarker and Prognostic Factor in Osteosarcoma: Data Mining from Oncomine and the Cancer Genome Atlas Databases.,2021,10.1155/2021/6885897,https://pubmed.ncbi.nlm.nih.gov/34307667/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,26468294,"Human MageB2 Protein Expression Enhances E2F Transcriptional Activity, Cell Proliferation, and Resistance to Ribotoxic Stress.",2015,10.1074/jbc.m115.671982,https://pubmed.ncbi.nlm.nih.gov/26468294/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,23029077,MAGEB2 is activated by promoter demethylation in head and neck squamous cell carcinoma.,2012,10.1371/journal.pone.0045534,https://pubmed.ncbi.nlm.nih.gov/23029077/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,21791470,Cancer testis antigens in newly diagnosed and relapse multiple myeloma: prognostic markers and potential targets for immunotherapy.,2011,10.3324/haematol.2010.037978,https://pubmed.ncbi.nlm.nih.gov/21791470/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,26830021,Proteome-wide survey of the autoimmune target repertoire in autoimmune polyendocrine syndrome type 1.,2016,10.1038/srep20104,https://pubmed.ncbi.nlm.nih.gov/26830021/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,16806467,mRNA expression of MAGE-A3 gene in leukemia cells.,2007,10.1016/j.leukres.2006.05.009,https://pubmed.ncbi.nlm.nih.gov/16806467/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,16367908,Identification of tumor associated antigens recognized by IgG from tumor-infiltrating B cells of lung cancer: correlation between Ab titer of the patient's sera and the clinical course.,2005,10.1111/j.1349-7006.2005.00119.x,https://pubmed.ncbi.nlm.nih.gov/16367908/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,20381863,The DNA demethylating agent 5-aza-2'-deoxycytidine induces expression of NY-ESO-1 and other cancer/testis antigens in myeloid leukemia cells.,2010,10.1016/j.leukres.2010.02.004,https://pubmed.ncbi.nlm.nih.gov/20381863/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,21785609,Expression patterns of cancer-testis antigens in human embryonic stem cells and their cell derivatives indicate lineage tracks.,2011,10.4061/2011/795239,https://pubmed.ncbi.nlm.nih.gov/21785609/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB2,ENSG00000099399,Unsafe,23574628,"Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene.",2013,10.1111/tan.12113,https://pubmed.ncbi.nlm.nih.gov/23574628/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,37451217,"MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.",2023,10.1016/j.bbrc.2023.07.013,https://pubmed.ncbi.nlm.nih.gov/37451217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,39318439,Partial Lipodystrophy Affecting the Extremities in a Young Woman With Autoimmune Polyglandular Syndrome 1.,2024,10.1210/jcemcr/luae166,https://pubmed.ncbi.nlm.nih.gov/39318439/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,41882697,SIRT1 haploinsufficiency recapitulates age-associated subfertility through sperm α-tubulin hyperacetylation.,2026,10.1186/s13062-025-00710-2,https://pubmed.ncbi.nlm.nih.gov/41882697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,41592893,Autoantibodies as predictors for immune-related adverse events in checkpoint inhibition therapy of metastatic melanoma.,2026,10.1136/jitc-2025-013814,https://pubmed.ncbi.nlm.nih.gov/41592893/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,35303799,MAGE genes encoding for embryonic development in cattle is mainly regulated by zinc finger transcription factor family and slightly by CpG Islands.,2022,10.1186/s12863-022-01034-0,https://pubmed.ncbi.nlm.nih.gov/35303799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,35937396,Expression Profile of MAGE-B1 Gene and Its Hypomethylation Activation in Colon Cancer.,2022,10.1155/2022/6066567,https://pubmed.ncbi.nlm.nih.gov/35937396/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,36317868,TCR CDR3-antigen chemical complementarity associated with poor ovarian cancer outcomes: A vestigial immune response to early cancer antigens?,2023,10.1111/aji.13639,https://pubmed.ncbi.nlm.nih.gov/36317868/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,31069014,Large-scale in-silico identification of a tumor-specific antigen pool for targeted immunotherapy in triple-negative breast cancer.,2019,10.18632/oncotarget.26808,https://pubmed.ncbi.nlm.nih.gov/31069014/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,30464633,Urine exosome gene expression of cancer-testis antigens for prediction of bladder carcinoma.,2018,10.2147/cmar.s180389,https://pubmed.ncbi.nlm.nih.gov/30464633/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,28401488,A no-stop mutation in MAGEB4 is a possible cause of rare X-linked azoospermia and oligozoospermia in a consanguineous Turkish family.,2017,10.1007/s10815-017-0900-z,https://pubmed.ncbi.nlm.nih.gov/28401488/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,29058301,Cancer-Testis Antigens as New Candidate Diagnostic Biomarkers for Transitional Cell Carcinoma of Bladder.,2019,10.1007/s12253-017-0313-4,https://pubmed.ncbi.nlm.nih.gov/29058301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,28865418,"ODF4, MAGEA3, and MAGEB4: Potential Biomarkers in Patients with Transitional Cell Carcinoma",2018,10.22034/ibj.22.3.160,https://pubmed.ncbi.nlm.nih.gov/28865418/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,31143371,Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells.,2019,10.18632/oncotarget.26933,https://pubmed.ncbi.nlm.nih.gov/31143371/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,34307667,Trophinin Is an Important Biomarker and Prognostic Factor in Osteosarcoma: Data Mining from Oncomine and the Cancer Genome Atlas Databases.,2021,10.1155/2021/6885897,https://pubmed.ncbi.nlm.nih.gov/34307667/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,31516568,Prognostic roles of MAGE family members in breast cancer based on KM-Plotter Data.,2019,10.3892/ol.2019.10722,https://pubmed.ncbi.nlm.nih.gov/31516568/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,32941982,A comprehensive analysis of the MAGE family as prognostic and diagnostic markers for hepatocellular carcinoma.,2020,10.1016/j.ygeno.2020.09.026,https://pubmed.ncbi.nlm.nih.gov/32941982/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,36749097,Autoantibody screening of plasma and peritoneal fluid of patients with endometriosis.,2023,10.1093/humrep/dead011,https://pubmed.ncbi.nlm.nih.gov/36749097/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,24619130,Reconstruction of mouse testicular cellular microenvironments in long-term seminiferous tubule culture.,2014,10.1371/journal.pone.0090088,https://pubmed.ncbi.nlm.nih.gov/24619130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,10706124,"Mage-b4, a novel melanoma antigen (MAGE) gene specifically expressed during germ cell differentiation.",2000,,https://pubmed.ncbi.nlm.nih.gov/10706124/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAGEB4,ENSG00000120289,Unsafe,9441743,Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins.,1997,10.1006/geno.1997.5052,https://pubmed.ncbi.nlm.nih.gov/9441743/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42657331,"Pentaborane: MAK Value Documentation, addendum - Translation of the German version from 2024.",2026,10.34865/mb1962422e11_2ad,https://pubmed.ncbi.nlm.nih.gov/42657331/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42657076,Benzidine and its salts: MAK Value Documentation - Translation of the German version from 2024.,2026,10.34865/mb9287e11_2or,https://pubmed.ncbi.nlm.nih.gov/42657076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42721646,Elevated mitochondrial superoxide promotes longevity through a mitochondria-to-nucleus kinase signaling pathway.,2026,10.1016/j.redox.2026.104385,https://pubmed.ncbi.nlm.nih.gov/42721646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,41971572,Tetrabromobisphenol A: MAK Value Documentation - Translation of the German version from 2023.,2025,10.34865/mb7994e10_4or,https://pubmed.ncbi.nlm.nih.gov/41971572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42639134,Diethylene glycol monomethyl ether: MAK Value Documentation - Translation of the German version from 2024.,2026,10.34865/mb11177e11_1or,https://pubmed.ncbi.nlm.nih.gov/42639134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42126134,MAK-2 Kinase Is Required for Extended Longevity and Enhanced Stress Resistance Resulting From Mild Impairment of Mitochondrial Function in isp-1 Mutants.,2026,10.1111/acel.70537,https://pubmed.ncbi.nlm.nih.gov/42126134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42657204,Benzophenon-3: MAK-Begründung.,2026,10.34865/mb13157d11_2or,https://pubmed.ncbi.nlm.nih.gov/42657204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42195225,"A Randomized, Double-Blind, Placebo-Controlled Trial of an Ayurvedic Herbal Formulation and Vitamin C/E on Vascular Function in Patients with Cardiovascular Disease.",2026,10.3390/medicina62050972,https://pubmed.ncbi.nlm.nih.gov/42195225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,41915693,Characterization of EOP-1 reveals cell autonomous oscillations preceding somatic cell fusion in Neurospora crassa.,2026,10.1371/journal.pgen.1012087,https://pubmed.ncbi.nlm.nih.gov/41915693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42222164,Cardioprotective potential of Maharishi Amrit Kalash: a scoping review of evidence from experimental and clinical studies.,2026,10.3389/fphar.2026.1799117,https://pubmed.ncbi.nlm.nih.gov/42222164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42657350,"Trimethylbenzol (alle Isomere): MAK-Begründung, Nachtrag.",2026,10.34865/mb2555113ismd11_2ad,https://pubmed.ncbi.nlm.nih.gov/42657350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42639114,"Naphtha (petroleum), hydrotreated heavy: MAK Value Documentation, addendum - Translation of the German version from 2025.",2026,10.34865/mb6474248yole11_1ad,https://pubmed.ncbi.nlm.nih.gov/42639114/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42639480,"Methyldiethanolamine: MAK Value Documentation, addendum - Translation of the German version from 2024.",2026,10.34865/mb10559kske11_1ad,https://pubmed.ncbi.nlm.nih.gov/42639480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42639090,"Benzylalkoholmono(poly)hemiformal: MAK-Begründung, Nachtrag.",2026,10.34865/mb1454860kskd11_1ad,https://pubmed.ncbi.nlm.nih.gov/42639090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42639483,"Decaboran: MAK-Begründung, Nachtrag.",2026,10.34865/mb1770241d11_1ad,https://pubmed.ncbi.nlm.nih.gov/42639483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42657353,"2,2'-Dichlorodiethyl ether: MAK Value Documentation, addendum - Translation of the German version from 2023.",2026,10.34865/mb11144e11_2ad,https://pubmed.ncbi.nlm.nih.gov/42657353/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42639475,"1,3-Dimethylol-5,5-dimethylhydantoin: MAK-Begründung, Nachtrag.",2026,10.34865/mb644058kskd11_1ad,https://pubmed.ncbi.nlm.nih.gov/42639475/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42639176,"Hexamethylentetramin: MAK-Begründung, Nachtrag.",2026,10.34865/mb10097kskd11_1ad,https://pubmed.ncbi.nlm.nih.gov/42639176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,41971562,"Synthetic amorphous silica: MAK Value Documentation, addendum - Translation of the German version from 2023.",2025,10.34865/mb763186e10_4ad,https://pubmed.ncbi.nlm.nih.gov/41971562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,41575991,Formononetin ameliorates SP-induced urticaria in mice via suppressing TAK1/MAK signaling pathway.,2026,10.1371/journal.pone.0340078,https://pubmed.ncbi.nlm.nih.gov/41575991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42657395,"Propoxur: MAK Value Documentation, addendum - Translation of the German version from 2024.",2026,10.34865/mb11426e11_2ad,https://pubmed.ncbi.nlm.nih.gov/42657395/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42657166,"Mevinphos: MAK Value Documentation, addendum - Translation of the German version from 2024.",2026,10.34865/mb778634e11_2ad,https://pubmed.ncbi.nlm.nih.gov/42657166/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42657373,"Carbaryl: MAK Value Documentation, addendum - Translation of the German version from 2024.",2026,10.34865/mb6325e11_2ad,https://pubmed.ncbi.nlm.nih.gov/42657373/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42657406,"Fenthion: MAK Value Documentation, addendum - Translation of the German version from 2024.",2026,10.34865/mb5538e11_2ad,https://pubmed.ncbi.nlm.nih.gov/42657406/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42657084,"Parathion: MAK Value Documentation, addendum - Translation of the German version from 2024.",2026,10.34865/mb5638e11_2ad,https://pubmed.ncbi.nlm.nih.gov/42657084/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42657377,"EPN (&lt;i&gt;O&lt;/i&gt;-ethyl-&lt;i&gt;O&lt;/i&gt;-(4-nitrophenyl)-phenylthiophosphonate): MAK Value Documentation, addendum - Translation of the German version from 2024.",2026,10.34865/mb210464e11_2ad,https://pubmed.ncbi.nlm.nih.gov/42657377/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42657365,"Malathion: MAK Value Documentation, addendum - Translation of the German version from 2024.",2026,10.34865/mb12175e11_2ad,https://pubmed.ncbi.nlm.nih.gov/42657365/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42657368,"Demeton methyl: MAK Value Documentation, addendum - Translation of the German version from 2024.",2026,10.34865/mb802200e11_2ad,https://pubmed.ncbi.nlm.nih.gov/42657368/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42657168,"TEPP (&lt;i&gt;O&lt;/i&gt;,&lt;i&gt;O&lt;/i&gt;,&lt;i&gt;O&lt;/i&gt;,&lt;i&gt;O&lt;/i&gt;-tetraethyl-pyrophosphate): MAK Value Documentation, addendum - Translation of the German version from 2024.",2026,10.34865/mb10749e11_2ad,https://pubmed.ncbi.nlm.nih.gov/42657168/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42657371,"2-Butoxyethylacetat: MAK-Begründung, Nachtrag.",2026,10.34865/mb11207d11_2ad,https://pubmed.ncbi.nlm.nih.gov/42657371/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42639122,"Dichlorofluoromethane: MAK Value Documentation, addendum - Translation of the German version from 2024.",2026,10.34865/mb7543e11_1ad,https://pubmed.ncbi.nlm.nih.gov/42639122/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42657416,"N-Methylanilin: MAK-Begründung, Nachtrag.",2026,10.34865/mb10061d11_2ad,https://pubmed.ncbi.nlm.nih.gov/42657416/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42639482,"1,2-Dichloro-1,1,2,2-tetrafluoro-ethane: MAK Value Documentation, addendum - Translation of the German version from 2024.",2026,10.34865/mb7614e11_1ad,https://pubmed.ncbi.nlm.nih.gov/42639482/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42657357,"Xylidin, Isomere (2,3-Xylidin, 2,5-Xylidin, 3,4-Xylidin, 3,5-Xylidin): MAK-Begründung, Nachtrag.",2026,10.34865/mb8759ismd11_2ad,https://pubmed.ncbi.nlm.nih.gov/42657357/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42657336,"2-Butoxyethanol: MAK-Begründung, Nachtrag.",2026,10.34865/mb11176d11_2ad,https://pubmed.ncbi.nlm.nih.gov/42657336/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,42639126,"2-(Propyloxy)ethyl acetate: MAK Value Documentation, addendum - Translation of the German version from 2024.",2026,10.34865/mb280730e11_1ad,https://pubmed.ncbi.nlm.nih.gov/42639126/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,41971566,"Benzoic acid (inhalable fraction): MAK Value Documentation, addendum - Translation of the German version from 2023.",2025,10.34865/mb6585e10_4ad,https://pubmed.ncbi.nlm.nih.gov/41971566/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,21825139,Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa.,2011,10.1073/pnas.1108918108,https://pubmed.ncbi.nlm.nih.gov/21825139/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAK,ENSG00000111837,Unsafe,12084720,"Identification of human male germ cell-associated kinase, a kinase transcriptionally activated by androgen in prostate cancer cells.",2002,10.1074/jbc.m203940200,https://pubmed.ncbi.nlm.nih.gov/12084720/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP10,ENSG00000212916,Unsafe,39859313,"Transcriptome Analysis Suggests PKD3 Regulates Proliferative Glucose Metabolism, Calcium Homeostasis and Microtubule Dynamics After MEF Spontaneous Immortalization.",2025,10.3390/ijms26020596,https://pubmed.ncbi.nlm.nih.gov/39859313/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP10,ENSG00000212916,Unsafe,23264731,"MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis.",2013,10.1242/jcs.116137,https://pubmed.ncbi.nlm.nih.gov/23264731/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP10,ENSG00000212916,Unsafe,40980161,Improving risk stratification and detection of early HCC using ultrasound-based deep learning models.,2025,10.1016/j.jhepr.2025.101510,https://pubmed.ncbi.nlm.nih.gov/40980161/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP10,ENSG00000212916,Unsafe,36252502,Effect of aerobic and modified atmosphere packaging on quality characteristics of chicken leg meat at refrigerated storage.,2022,10.1016/j.psj.2022.102170,https://pubmed.ncbi.nlm.nih.gov/36252502/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP10,ENSG00000212916,Unsafe,32321919,A high definition picture of somatic mutations in chronic lymphoproliferative disorder of natural killer cells.,2020,10.1038/s41408-020-0309-2,https://pubmed.ncbi.nlm.nih.gov/32321919/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP10,ENSG00000212916,Unsafe,15908411,Expression cloning of gamma interferon-inducing antigens of Mycobacterium avium subsp. paratuberculosis.,2005,10.1128/iai.73.6.3778-3782.2005,https://pubmed.ncbi.nlm.nih.gov/15908411/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP10,ENSG00000212916,Unsafe,35872786,Deep Learning Model for Predicting Intradialytic Hypotension Without Privacy Infringement: A Retrospective Two-Center Study.,2022,10.3389/fmed.2022.878858,https://pubmed.ncbi.nlm.nih.gov/35872786/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,42411568,Patient-derived forebrain cortical organoids reveal biphasic tau-MAP6-microtubule axis dysfunction in tauopathy.,2026,10.1002/alz.71565,https://pubmed.ncbi.nlm.nih.gov/42411568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,42069089,Proper localization of the SCA13-linked K&lt;sup&gt;+&lt;/sup&gt; channel in Purkinje neurons requires a microtubule-stabilizing protein.,2026,10.1016/j.nbd.2026.107429,https://pubmed.ncbi.nlm.nih.gov/42069089/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,41825505,The MAP6-NTS axis in hippocampal CA1 regulates synaptic plasticity and memory.,2026,10.1016/j.neuropharm.2026.110921,https://pubmed.ncbi.nlm.nih.gov/41825505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,42563243,Microtubules in Spinal Cord Injury: From Cytoskeletal Dysregulation to Therapeutic Regeneration.,2026,10.1111/jnc.70537,https://pubmed.ncbi.nlm.nih.gov/42563243/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,42588969,Gene Ontology-Based Comparative Transcriptomics Provides Evidence of Genetic Adaptations in the &lt;i&gt;Rhinolophus macrotis&lt;/i&gt; Group (Chiroptera: Rhinolophidae).,2026,10.3390/ani16152331,https://pubmed.ncbi.nlm.nih.gov/42588969/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,41707770,Targeting CXCL16-expressing macrophages with a biomimetic nanocarrier system attenuates cartilage degeneration in osteoarthritis.,2026,10.1016/j.jconrel.2026.114734,https://pubmed.ncbi.nlm.nih.gov/41707770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,40910579,BioID2-Based Tau Interactome Reveals Novel and Known Protein Interactions Associated with Multiple Cellular Pathways.,2025,10.1021/acs.jproteome.5c00473,https://pubmed.ncbi.nlm.nih.gov/40910579/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,40040809,Tau and MAP6 establish labile and stable domains on microtubules.,2025,10.1016/j.isci.2025.111785,https://pubmed.ncbi.nlm.nih.gov/40040809/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,39257379,Antagonistic roles of tau and MAP6 in regulating neuronal development.,2024,10.1242/jcs.261966,https://pubmed.ncbi.nlm.nih.gov/39257379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,37833406,"A cytoskeleton-membrane interaction conserved in fast-spiking neurons controls movement, emotion, and memory.",2023,10.1038/s41380-023-02286-7,https://pubmed.ncbi.nlm.nih.gov/37833406/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,39980902,Whole Genome Variable Number Tandem Repeat Analysis in Alzheimer Disease.,2025,10.1212/nxg.0000000000200241,https://pubmed.ncbi.nlm.nih.gov/39980902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,35870679,Traumatic brain injury recapitulates developmental changes of axons.,2022,10.1016/j.pneurobio.2022.102332,https://pubmed.ncbi.nlm.nih.gov/35870679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,34025352,"Beyond Neuronal Microtubule Stabilization: MAP6 and CRMPS, Two Converging Stories.",2021,10.3389/fnmol.2021.665693,https://pubmed.ncbi.nlm.nih.gov/34025352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,37252337,Exploration and Validation of Pancreatic Cancer Hub Genes Based on Weighted Gene Co-Expression Network Analysis and Immune Infiltration Score Analysis.,2023,10.2147/pgpm.s403116,https://pubmed.ncbi.nlm.nih.gov/37252337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,37819557,Reevaluating tau reduction as a therapeutic approach for tauopathies: Insights and perspectives.,2024,10.1002/cm.21790,https://pubmed.ncbi.nlm.nih.gov/37819557/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,34860155,CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway.,2021,10.7554/elife.70361,https://pubmed.ncbi.nlm.nih.gov/34860155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,31289257,"Role of microtubule-associated protein 6 glycosylated with Gal-(β-1,3)-GalNAc in Parkinson's disease.",2019,10.18632/aging.102072,https://pubmed.ncbi.nlm.nih.gov/31289257/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,38482432,A centrosome-related gene signature for predicting the overall survival of uveal melanoma.,2024,10.21037/tcr-23-1486,https://pubmed.ncbi.nlm.nih.gov/38482432/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,36606207,Tubulin Isotypes and Posttranslational Modifications in Vascular Dementia and Alzheimer's Disease.,2022,10.3233/adr-220068,https://pubmed.ncbi.nlm.nih.gov/36606207/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,30231928,Deletion of the microtubule-associated protein 6 (MAP6) results in skeletal muscle dysfunction.,2018,10.1186/s13395-018-0176-8,https://pubmed.ncbi.nlm.nih.gov/30231928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,33103814,Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and Neurotoxicity.,2021,10.1002/mds.28346,https://pubmed.ncbi.nlm.nih.gov/33103814/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,29094416,MAP6 interacts with Tctex1 and Cav 2.2/N-type calcium channels to regulate calcium signalling in neurons.,2017,10.1111/ejn.13766,https://pubmed.ncbi.nlm.nih.gov/29094416/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,34660263,Expression of Microtubule-Associated Proteins in Relation to Prognosis and Efficacy of Immunotherapy in Non-Small Cell Lung Cancer.,2021,10.3389/fonc.2021.680402,https://pubmed.ncbi.nlm.nih.gov/34660263/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,31245373,Acylation - A New Means to Control Traffic Through the Golgi.,2019,10.3389/fcell.2019.00109,https://pubmed.ncbi.nlm.nih.gov/31245373/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,24357581,The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes.,2014,10.1002/embj.201385857,https://pubmed.ncbi.nlm.nih.gov/24357581/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,25484074,New horizons in schizophrenia treatment: autophagy protection is coupled with behavioral improvements in a mouse model of schizophrenia.,2014,10.4161/15548627.2014.984274,https://pubmed.ncbi.nlm.nih.gov/25484074/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,23002183,Reduced expression of STOP/MAP6 in mice leads to cognitive deficits.,2013,10.1093/schbul/sbs113,https://pubmed.ncbi.nlm.nih.gov/23002183/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,28980356,ReMAPping the microtubule landscape: How phosphorylation dictates the activities of microtubule-associated proteins.,2018,10.1002/dvdy.24599,https://pubmed.ncbi.nlm.nih.gov/28980356/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,21902667,Microtubules (tau) as an emerging therapeutic target: NAP (davunetide).,2011,10.2174/138161211798072553,https://pubmed.ncbi.nlm.nih.gov/21902667/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,16624526,Genetic and expression analyses of the STOP (MAP6) gene in schizophrenia.,2006,10.1016/j.schres.2006.03.017,https://pubmed.ncbi.nlm.nih.gov/16624526/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP6,ENSG00000171533,Unsafe,14692697,Stable tubule only polypeptides (STOP) proteins co-aggregate with spheroid neurofilaments in amyotrophic lateral sclerosis.,2003,10.1093/jnen/62.12.1211,https://pubmed.ncbi.nlm.nih.gov/14692697/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP7D2,ENSG00000184368,Unsafe,42471418,Construction and mechanism of histone deacetylation related gene prognosis model in esophageal carcinoma.,2026,10.1038/s41598-026-62870-z,https://pubmed.ncbi.nlm.nih.gov/42471418/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP7D2,ENSG00000184368,Unsafe,35470240,Map7D2 and Map7D1 facilitate microtubule stabilization through distinct mechanisms in neuronal cells.,2022,10.26508/lsa.202201390,https://pubmed.ncbi.nlm.nih.gov/35470240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP7D2,ENSG00000184368,Unsafe,36081350,MAP7D2 reduces CD8+ cytotoxic T lymphocyte infiltration through MYH9-HMGB1 axis in colorectal cancer.,2023,10.1016/j.ymthe.2022.09.001,https://pubmed.ncbi.nlm.nih.gov/36081350/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP7D2,ENSG00000184368,Unsafe,40550064,Molecular insights into gender-specific differences in rheumatoid arthritis: A study using high-throughput sequencing and Mendelian randomization.,2025,10.1097/md.0000000000042960,https://pubmed.ncbi.nlm.nih.gov/40550064/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP7D2,ENSG00000184368,Unsafe,36896235,The genetic contribution of the X chromosome in age-related hearing loss.,2023,10.3389/fgene.2023.1106328,https://pubmed.ncbi.nlm.nih.gov/36896235/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP7D2,ENSG00000184368,Unsafe,39731868,Whole genome and transcriptome analysis of pancreatic acinar cell carcinoma elucidates mechanisms of homologous recombination deficiency and unravels novel relevant fusion events.,2025,10.1016/j.prp.2024.155798,https://pubmed.ncbi.nlm.nih.gov/39731868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP7D2,ENSG00000184368,Unsafe,39818173,Construction of a stromal-related prognostic model in acute myeloid leukemia by comprehensive bioinformatics analysis.,2025,10.1016/j.retram.2025.103492,https://pubmed.ncbi.nlm.nih.gov/39818173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP7D2,ENSG00000184368,Unsafe,33568133,Screening of Graves' disease susceptibility genes by whole exome sequencing in a three-generation family.,2021,10.1186/s12920-020-00865-z,https://pubmed.ncbi.nlm.nih.gov/33568133/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP7D2,ENSG00000184368,Unsafe,30784582,MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon.,2019,10.1016/j.celrep.2019.01.084,https://pubmed.ncbi.nlm.nih.gov/30784582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP7D2,ENSG00000184368,Unsafe,35282117,Analysis of cancer-promoting genes related to chemotherapy resistance in esophageal squamous cell carcinoma.,2022,10.21037/atm-21-7032,https://pubmed.ncbi.nlm.nih.gov/35282117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP7D2,ENSG00000184368,Unsafe,34116169,Sex-specific gene expression in the blood of four primates.,2021,10.1016/j.ygeno.2021.06.007,https://pubmed.ncbi.nlm.nih.gov/34116169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP7D2,ENSG00000184368,Unsafe,30065754,Identification of Potential Key Genes Associated With the Pathogenesis and Prognosis of Gastric Cancer Based on Integrated Bioinformatics Analysis.,2018,10.3389/fgene.2018.00265,https://pubmed.ncbi.nlm.nih.gov/30065754/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MAP7D2,ENSG00000184368,Unsafe,32156473,"Genomic profiling of BCOR-rearranged uterine sarcomas reveals novel gene fusion partners, frequent CDK4 amplification and CDKN2A loss.",2020,10.1016/j.ygyno.2020.02.024,https://pubmed.ncbi.nlm.nih.gov/32156473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MARCHF10,ENSG00000173838,Unsafe,40749991,Ubiquitin E3 ligase MARCH10 targets influenza hemagglutinin for ubiquitination.,2025,10.1016/j.cellsig.2025.112035,https://pubmed.ncbi.nlm.nih.gov/40749991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MARCHF10,ENSG00000173838,Unsafe,36852930,Influenza virus reduces ubiquitin E3 ligase MARCH10 expression to decrease ciliary beat frequency.,2023,10.1152/ajplung.00191.2022,https://pubmed.ncbi.nlm.nih.gov/36852930/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MARCHF10,ENSG00000173838,Unsafe,40593057,The genomic comparison between autochthonous and cosmopolitan cows reveals structural variants involved in environmental adaptation.,2025,10.1038/s41598-025-07165-5,https://pubmed.ncbi.nlm.nih.gov/40593057/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MARCHF10,ENSG00000173838,Unsafe,36419110,Whole-exome sequencing identifies novel protein-altering variants associated with serum apolipoprotein and lipid concentrations.,2022,10.1186/s13073-022-01135-6,https://pubmed.ncbi.nlm.nih.gov/36419110/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MARCHF10,ENSG00000173838,Unsafe,21937444,Membrane-associated RING-CH 10 (MARCH10 protein) is a microtubule-associated E3 ubiquitin ligase of the spermatid flagella.,2011,10.1074/jbc.m111.256875,https://pubmed.ncbi.nlm.nih.gov/21937444/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MARCHF10,ENSG00000173838,Unsafe,31021853,Comprehensive Molecular Characterization of Adamantinoma and OFD-like Adamantinoma Bone Tumors.,2019,10.1097/pas.0000000000001251,https://pubmed.ncbi.nlm.nih.gov/31021853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MARCHF11,ENSG00000183654,Unsafe,42260403,EVX2 methylation assay enables risk assessment of cervical cancer in high-risk HPV-infected individuals.,2026,10.1186/s12885-026-16256-z,https://pubmed.ncbi.nlm.nih.gov/42260403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MARCHF11,ENSG00000183654,Unsafe,40150354,Genome-Wide Association Study Reveals Novel Loci and Candidate Genes for Birth Weight in Pigs.,2025,10.3390/ani15060825,https://pubmed.ncbi.nlm.nih.gov/40150354/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MARCHF11,ENSG00000183654,Unsafe,38858548,Anaplastic Lymphoma Kinase signaling stabilizes SLC3A2 expression via MARCH11 to promote neuroblastoma cell growth.,2024,10.1038/s41418-024-01319-0,https://pubmed.ncbi.nlm.nih.gov/38858548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MARCHF11,ENSG00000183654,Unsafe,35721535,Identification of Genes Reveals the Mechanism of Cell Ferroptosis in Diabetic Nephropathy.,2022,10.3389/fphys.2022.890566,https://pubmed.ncbi.nlm.nih.gov/35721535/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MARCHF11,ENSG00000183654,Unsafe,22075566,Identification of SAMT family proteins as substrates of MARCH11 in mouse spermatids.,2012,10.1007/s00418-011-0887-y,https://pubmed.ncbi.nlm.nih.gov/22075566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MARCHF11,ENSG00000183654,Unsafe,34440337,"Genome-Wide Association Study Using Whole-Genome Sequence Data for Fertility, Health Indicator, and Endoparasite Infection Traits in German Black Pied Cattle.",2021,10.3390/genes12081163,https://pubmed.ncbi.nlm.nih.gov/34440337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MARCHF11,ENSG00000183654,Unsafe,31148503,Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis.,2019,10.1289/ehp4522,https://pubmed.ncbi.nlm.nih.gov/31148503/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MARCHF11,ENSG00000183654,Unsafe,28855354,A Panel of Novel Detection and Prognostic Methylated DNA Markers in Primary Non-Small Cell Lung Cancer and Serum DNA.,2017,10.1158/1078-0432.ccr-17-1222,https://pubmed.ncbi.nlm.nih.gov/28855354/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MATCAP2,ENSG00000164542,Unsafe,41469117,Biological Features of Gastric Cancer After Neoadjuvant Chemotherapy.,2026,10.21873/anticanres.17937,https://pubmed.ncbi.nlm.nih.gov/41469117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MATCAP2,ENSG00000164542,Unsafe,37703372,A family of carboxypeptidases catalyzing α- and β-tubulin tail processing and deglutamylation.,2023,10.1126/sciadv.adi7838,https://pubmed.ncbi.nlm.nih.gov/37703372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MATCAP2,ENSG00000164542,Unsafe,38173016,"Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular aging.",2024,10.1186/s41065-023-00306-8,https://pubmed.ncbi.nlm.nih.gov/38173016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MATCAP2,ENSG00000164542,Unsafe,34773240,Identification of epigenetic modifications mediating the antagonistic effect of selenium against cadmium-induced breast carcinogenesis.,2022,10.1007/s11356-021-17355-z,https://pubmed.ncbi.nlm.nih.gov/34773240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,42322117,Aberrant splicing of MBD1 reshapes the epigenome to drive convergent myeloerythroid defects in MDS.,2026,10.1182/blood.2025030731,https://pubmed.ncbi.nlm.nih.gov/42322117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,42563211,DNA Replication Stress-Induced Transcriptome of Human Burkitt's Lymphoma Identifies Reciprocal Regulation Between MBD1 and BCL6 During Germinal Center-Derived B-Lymphomagenesis.,2026,10.1002/hon.70227,https://pubmed.ncbi.nlm.nih.gov/42563211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,42458680,Adult Erythroblastic Sarcoma With PCM1::JAK2 Fusion and a Novel NOP10::NUTM1 Fusion Complicated by Secondary HLH.,2026,10.1111/jcmm.71286,https://pubmed.ncbi.nlm.nih.gov/42458680/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,42622611,MBD1-Mediated SDHD Methylation Aggravates Preeclampsia Progression via Triggering Mitochondrial Dysfunction.,2026,10.1096/fj.202601983r,https://pubmed.ncbi.nlm.nih.gov/42622611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,42298117,Author Correction: PCM1 orchestrates centrosomal and flagellar protein transport to promote sperm maturation.,2026,10.1038/s42003-026-10450-2,https://pubmed.ncbi.nlm.nih.gov/42298117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,40481240,PCM1 orchestrates centrosomal and flagellar protein transport to promote sperm maturation.,2025,10.1038/s42003-025-08319-x,https://pubmed.ncbi.nlm.nih.gov/40481240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,42486827,"[MBD1 knockdown inhibits proliferation, migration and angiogenesis of human umbilical vein endothelial cells &lt;i&gt;in vitro&lt;/i&gt;].",2026,10.12122/j.issn.1673-4254.2026.07.12,https://pubmed.ncbi.nlm.nih.gov/42486827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,41942462,Downregulated transcription in chromosomal domains of midbrain dopamine neurons linked to schizophrenia.,2026,10.1038/s41467-026-71281-7,https://pubmed.ncbi.nlm.nih.gov/41942462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,40585997,A subset of evolutionarily conserved centriolar satellite core components is crucial for sperm flagellum biogenesis.,2025,10.7150/thno.117118,https://pubmed.ncbi.nlm.nih.gov/40585997/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,42185286,An HDAC4-specific PROTAC degrader achieves radiation sensitization by enhancing ferroptosis in lung cancer.,2026,10.1038/s41467-026-73682-0,https://pubmed.ncbi.nlm.nih.gov/42185286/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,41315244,PCM1 coordinates centrosome asymmetry with polarized endosome dynamics to regulate daughter cell fate.,2025,10.1038/s41467-025-65756-2,https://pubmed.ncbi.nlm.nih.gov/41315244/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,42724811,Exploring Genetic Clues in Kikuchi-Fujimoto Disease: A Three-Generation Study.,2026,10.2147/pgpm.s602876,https://pubmed.ncbi.nlm.nih.gov/42724811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,40801568,Loss of C-Terminal Coiled-Coil Domains in SDCCAG8 Impairs Centriolar Satellites and Causes Defective Sperm Flagellum Biogenesis and Male Fertility.,2025,10.3390/cells14151135,https://pubmed.ncbi.nlm.nih.gov/40801568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,42348320,Microtubule-associated CCDC112 is essential for spermiogenesis and male fertility in mice.,2026,10.1093/jmcb/mjag019,https://pubmed.ncbi.nlm.nih.gov/42348320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,41781170,Lactate supplementation modulates molecular and functional responses during chronic neuromuscular electrical stimulation in male rats.,2026,10.14814/phy2.70790,https://pubmed.ncbi.nlm.nih.gov/41781170/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,40396915,A conserved role for centriolar satellites in translation of centrosomal and ciliary proteins.,2025,10.1083/jcb.202408042,https://pubmed.ncbi.nlm.nih.gov/40396915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,41355489,Selective disruption of microtubule formation at the nuclear envelope impairs the bone resorption capacity of osteoclasts.,2026,10.1242/jcs.264166,https://pubmed.ncbi.nlm.nih.gov/41355489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,42123562,Genome-Wide DNA Methylation Profiling Reveals Ancestry-Associated Epigenetic Reprogramming in Cervical Intraepithelial Neoplasia.,2026,10.3390/ijms27093986,https://pubmed.ncbi.nlm.nih.gov/42123562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,39980500,A Case of Myeloproliferative Neoplasm with Eosinophilia Associated with PCM1-JAK2 Rearrangement.,2025,10.1159/000542692,https://pubmed.ncbi.nlm.nih.gov/39980500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,42299473,CEP131 Deficiency Leads to Multiple Morphological Abnormalities of the Sperm Flagellum-Associated Male Infertility via Impaired CEP290 Interaction.,2026,10.1111/andr.70280,https://pubmed.ncbi.nlm.nih.gov/42299473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,41530508,A case report and a literature review of Myeloid/Lymphoid Neoplasm with Eosinophilia and PCM1::JAK2 rearrangement representing as B-cell acute lymphoblastic leukemia B-ALL.,2026,10.1007/s00277-026-06757-z,https://pubmed.ncbi.nlm.nih.gov/41530508/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,41386881,Transcriptomics analysis unveils the complex interplay between diabetes and hypertension in regulating renal cell carcinoma pathway followed by pancreatic metastasis.,2025,10.1016/j.jgeb.2025.100616,https://pubmed.ncbi.nlm.nih.gov/41386881/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,41400112,Pediatric Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma With Unusually Long Clinical Course.,2026,10.1111/cup.70037,https://pubmed.ncbi.nlm.nih.gov/41400112/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,40624029,Phase change composite based on protic ionic liquids 2-hydroxyethylammonium lactate and stearic acid for thermal energy storage systems at intermediate temperatures.,2025,10.1038/s41598-025-08514-0,https://pubmed.ncbi.nlm.nih.gov/40624029/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,41296329,JAK2 Fusions in Adult Patients With Mycosis Fungoides and CD30 Lymphoproliferative Disorders.,2026,10.1001/jamadermatol.2025.4688,https://pubmed.ncbi.nlm.nih.gov/41296329/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,38600973,Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy.,2024,10.1016/j.isci.2024.109580,https://pubmed.ncbi.nlm.nih.gov/38600973/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,40870696,Engineered &lt;i&gt;Saccharomyces cerevisiae&lt;/i&gt; for the Enhancement of Glucosamine Accumulation by the Consumption of Glucose and Ammonium Based on Synthetic Biological Pathways.,2025,10.3390/foods14162783,https://pubmed.ncbi.nlm.nih.gov/40870696/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,34707996,Diagnosis and Treatment of Myeloproliferative Neoplasms With PCM1-JAK2 Rearrangement: Case Report and Literature Review.,2021,10.3389/fonc.2021.753842,https://pubmed.ncbi.nlm.nih.gov/34707996/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,41072883,"Genomic Profiling of Pediatric Mycosis Fungoides, Lymphomatoid Papulosis, and Primary Cutaneous Anaplastic Large Cell Lymphoma Identifies Recurrent Tyrosine Kinase Gene Fusions.",2025,10.1016/j.modpat.2025.100908,https://pubmed.ncbi.nlm.nih.gov/41072883/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,38587452,Cell-Cycle-Specific Autoencoding Improves Cluster Analysis of Cycling Cardiomyocytes.,2024,10.1093/stmcls/sxae016,https://pubmed.ncbi.nlm.nih.gov/38587452/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,36829466,Transcriptomic Analysis of Hepatitis B Infected Liver for Prediction of Hepatocellular Carcinoma.,2023,10.3390/biology12020188,https://pubmed.ncbi.nlm.nih.gov/36829466/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,40951761,Molecular treatment options for patients carrying &lt;i&gt;KIAA0586/TALPID3&lt;/i&gt; variants.,2025,10.1016/j.omtn.2025.102688,https://pubmed.ncbi.nlm.nih.gov/40951761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,39105620,TLE3 Is a Novel Fusion Partner of JAK2 in Myeloid/Lymphoid Neoplasm With Eosinophilia Responding to JAK2 Inhibition.,2024,10.1002/gcc.23261,https://pubmed.ncbi.nlm.nih.gov/39105620/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,37640708,DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability.,2023,10.1038/s41467-023-40952-0,https://pubmed.ncbi.nlm.nih.gov/37640708/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,35786767,PCM1::JAK2 fusion associates with an atypical form of mycosis fungoides.,2022,10.1007/s00428-022-03372-x,https://pubmed.ncbi.nlm.nih.gov/35786767/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,35472244,PCM1-JAK2 Fusion Tyrosine Kinase Gene-Related Neoplasia: A Systematic Review of the Clinical Literature.,2022,10.1093/oncolo/oyac072,https://pubmed.ncbi.nlm.nih.gov/35472244/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,35028141,Sequential allogeneic transplantation and ruxolitinib maintenance for a synchronous PCM1-JAK2 positive myeloid sarcoma and acute B-lymphoblastic leukemia.,2022,10.1002/ccr3.5212,https://pubmed.ncbi.nlm.nih.gov/35028141/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD1,ENSG00000141644,Unsafe,9207790,A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins.,1997,10.1038/ng0797-256,https://pubmed.ncbi.nlm.nih.gov/9207790/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,41630910,Functional diversity of BAI1 (ADGRB1): From angiostasis to synaptic remodeling and disease therapeutics.,2026,10.1016/j.isci.2026.114656,https://pubmed.ncbi.nlm.nih.gov/41630910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,42265734,Macrophage PSRC1 attenuates atherosclerosis via extracellular vesicle-mediated MBD2 delivery to induce PCSK9 promoter methylation in hepatocytes.,2026,10.1186/s13578-026-01598-9,https://pubmed.ncbi.nlm.nih.gov/42265734/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,42084802,MBD2 suppresses SFRP1 expression and promotes colorectal cancer development by blocking MED19 binding to its methylated promoter.,2026,10.1080/15384047.2026.2667568,https://pubmed.ncbi.nlm.nih.gov/42084802/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,42020370,"Glutamate-induced nuclear translocation of PYK2 in hippocampal neurons, interaction with MBD2, and role in cell death in a model of epilepsy.",2026,10.1038/s41419-026-08628-x,https://pubmed.ncbi.nlm.nih.gov/42020370/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,41576700,Methylation reader MBD2-mediated GPX4 transcriptional repression drives ovarian granulosa cell ferroptosis in PCOS.,2026,10.1016/j.redox.2026.104034,https://pubmed.ncbi.nlm.nih.gov/41576700/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,42895066,Exploring the bistable equilibrium of methylated CpG DNA recognition by the MBD2 protein.,2026,10.1093/nar/gkag952,https://pubmed.ncbi.nlm.nih.gov/42895066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,42834249,Lactate-induced MBD2 K186 lactylation promotes YAP1-dependent myofibroblast-like remodeling of Müller cells in diabetic retinopathy.,2026,10.1186/s43556-026-00605-2,https://pubmed.ncbi.nlm.nih.gov/42834249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,41258082,Methyl-CpG-binding domain 2 mitigates osteoarthritis through Steap3 promoter methylation and chondrocyte ferroptosis regulation.,2025,10.1038/s12276-025-01586-y,https://pubmed.ncbi.nlm.nih.gov/41258082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,42511915,HBx-Associated Reactivation of the IGF2 Locus in Chronic HBV Infection and HBV-Related Hepatocarcinogenesis: Evidence Boundaries and Biomarker Implications.,2026,10.3390/biomedicines14071440,https://pubmed.ncbi.nlm.nih.gov/42511915/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,42353800,"DNMT1 and MBD2/3 Modulate Population Density-Dependent Plasticity in Terminal Oocyte Development in Bean Beetle, &lt;i&gt;Callosobruchus maculatus&lt;/i&gt;.",2026,10.3390/genes17060641,https://pubmed.ncbi.nlm.nih.gov/42353800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,40533455,"The role of MBD2 in immune cell development, function, and autoimmune diseases.",2025,10.1038/s41420-025-02563-0,https://pubmed.ncbi.nlm.nih.gov/40533455/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,41789066,Methyl-CpG-binding domain protein 2 epigenetically represses monocyte HLA-DR expression and promotes immune paralysis in HBV-related acute-on-chronic liver failure.,2026,10.3389/fimmu.2026.1694659,https://pubmed.ncbi.nlm.nih.gov/41789066/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,42429995,"A potent small-chemical MBD2 inhibitor, KCC-07, induces selective cytotoxicity in hepatocellular and prostate cancer cells.",2026,10.1007/s11033-026-12325-5,https://pubmed.ncbi.nlm.nih.gov/42429995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,42401357,BRD8 promotes non-small cell lung cancer progression by stabilizing MBD2 and activating the MAPK pathway.,2026,10.1016/j.cellsig.2026.112704,https://pubmed.ncbi.nlm.nih.gov/42401357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,41857481,The PKA/MBD2 Axis Transcriptionally Represses INPP5A to Modulate PI3K/Akt Signaling and Accelerate Pituitary Tumorigenesis.,2026,10.1002/cns.70817,https://pubmed.ncbi.nlm.nih.gov/41857481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,40937762,Loss of MBD2 is associated with tumor growth in small intestinal neuroendocrine tumors.,2025,10.1530/ec-25-0169,https://pubmed.ncbi.nlm.nih.gov/40937762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,40467564,MBD2 promotes B cell differentiation and BCR signaling in systemic lupus erythematosus by regulating the LEF-1-PTEN-PI3K axis.,2025,10.1038/s41419-025-07750-6,https://pubmed.ncbi.nlm.nih.gov/40467564/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,41416523,Heterochromatome wide analyses reveal MBD2 as a phase separation scaffold for heterochromatin compartmentalization and composition.,2025,10.1093/nar/gkaf1380,https://pubmed.ncbi.nlm.nih.gov/41416523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,40773897,MBD2 deficiency attenuates CCl&lt;sub&gt;4&lt;/sub&gt;-induced hepatic fibrosis by inhibiting M2 macrophage polarization.,2025,10.1016/j.intimp.2025.115306,https://pubmed.ncbi.nlm.nih.gov/40773897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,42500035,Targeted Transcriptional Repression by Induced Proximity.,2026,10.1021/acscentsci.5c02277,https://pubmed.ncbi.nlm.nih.gov/42500035/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,40252480,Aged mice-derived bronchial epithelial cells regulate Th17 cell differentiation in asthma via the MBD2-sICOSL axis.,2025,10.1016/j.cellimm.2025.104954,https://pubmed.ncbi.nlm.nih.gov/40252480/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,39865808,Methyl-CpG-Binding Domain Protein 2 is Involved in Th17 Cell Differentiation by Positively Regulating Leptin Expression.,2025,10.2174/0115665240341834250121080510,https://pubmed.ncbi.nlm.nih.gov/39865808/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,42342961,A novel lactylation-related gene signature deciphers the immunosuppressive microenvironment and stratifies precision therapy in colorectal cancer.,2026,10.1007/s12672-026-05245-0,https://pubmed.ncbi.nlm.nih.gov/42342961/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,39728572,Exposure to a Titanium Dioxide Product Alters DNA Methylation in Human Cells.,2024,10.3390/nano14242037,https://pubmed.ncbi.nlm.nih.gov/39728572/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,39865866,The methyl-CpG binding domain 2 regulates peptidylarginine deiminase 4 expression and promotes neutrophil extracellular trap formation via the Janus kinase 2 signaling pathway in experimental severe asthma.,2025,10.1080/07853890.2025.2458207,https://pubmed.ncbi.nlm.nih.gov/39865866/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,39932052,Development and Validation of Prognostic Characteristics Associated With Chromatin Remodeling-Related Genes in Ovarian Cancer.,2025,10.1002/cam4.70634,https://pubmed.ncbi.nlm.nih.gov/39932052/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,41915193,Fumonisin B1 exposure induces cardiac inflammation in C57BL/6 mice.,2026,10.1007/s00204-026-04342-x,https://pubmed.ncbi.nlm.nih.gov/41915193/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,41252065,DNA Methylation Patterns of 5mC Regulators: Insights into Immune Microenvironment Regulation in Heart Failure.,2026,10.1007/s12010-025-05465-0,https://pubmed.ncbi.nlm.nih.gov/41252065/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,40925882,"KCC-07, MBD2 Inhibitor, Expands the Therapeutic Window of DNA Damage Inducing Reagents in Neural Tumor Cells.",2025,10.5607/en25017,https://pubmed.ncbi.nlm.nih.gov/40925882/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,40395552,Comprehensive Analysis of RNA Modifications Related Genes in the Diagnosis and Subtype Classification of Dilated Cardiomyopathy.,2025,10.2147/jir.s498496,https://pubmed.ncbi.nlm.nih.gov/40395552/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,39563669,Effect of 5-Aza-2'-deoxycytidine on T-cell acute lymphoblastic leukemia cell biological behaviors and PTEN expression.,2024,10.25259/cytojournal_31_2024,https://pubmed.ncbi.nlm.nih.gov/39563669/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,40566980,Fumonisin B&lt;sub&gt;1&lt;/sub&gt; induces global DNA hypermethylation in human glioblastoma U87MG cells.,2025,10.1080/15592294.2025.2523690,https://pubmed.ncbi.nlm.nih.gov/40566980/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD2,ENSG00000134046,Unsafe,10050851,A mammalian protein with specific demethylase activity for mCpG DNA.,1999,10.1038/17533,https://pubmed.ncbi.nlm.nih.gov/10050851/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,42396457,Bridging MBD3 functions in developmental biology and glioma heterogeneity to immune remodeling with future perspectives.,2026,10.3389/fimmu.2026.1830872,https://pubmed.ncbi.nlm.nih.gov/42396457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,42738871,MBD3 Knockdown Promotes the Differentiation of Bovine iPSCs into Primordial Germ Cell-like Cells Associated with Altered Bivalent Modification of TGF-β-Related Genes.,2026,10.3390/cells15171577,https://pubmed.ncbi.nlm.nih.gov/42738871/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,41663664,MBD3 increased expression by BRD4 and facilitated castration-resistant prostate cancer cell proliferation by inhibiting PTEN.,2026,10.1007/s12672-026-04628-7,https://pubmed.ncbi.nlm.nih.gov/41663664/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,42873787,Autoimmunity induced by epigenome alteration affecting thymic Treg cell development.,2026,10.1073/pnas.2626262123,https://pubmed.ncbi.nlm.nih.gov/42873787/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,41933571,The role of MBD3 in cell biology and disease: Recent advances and future directions.,2026,10.1016/j.yexcr.2026.115002,https://pubmed.ncbi.nlm.nih.gov/41933571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,41060926,The role of Methyl-CpG binding domain 3 (Mbd3) protein in epileptogenesis.,2025,10.1371/journal.pone.0324580,https://pubmed.ncbi.nlm.nih.gov/41060926/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,41499431,MBD3 deficiency decommissions the nucleosome remodeling and deacetylase complex and orchestrates the epigenetic regulation of gene expression to suppress neuroblastoma progression.,2026,10.1093/neuonc/noaf297,https://pubmed.ncbi.nlm.nih.gov/41499431/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,40750707,Canonical Wnt signaling regulates Mbd3 protein stability during neurogenesis.,2025,10.1038/s12276-025-01510-4,https://pubmed.ncbi.nlm.nih.gov/40750707/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,41982165,Ubiquitin-dependent degradation of MBD3 by TRIM59 promotes lung adenocarcinoma.,2026,10.3724/abbs.2026044,https://pubmed.ncbi.nlm.nih.gov/41982165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,42595792,Targeting HDAC and proteostasis to eradicate quiescent cancer cells.,2026,10.1038/s41417-026-01067-y,https://pubmed.ncbi.nlm.nih.gov/42595792/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,42754823,IL-11 drives Treg cell differentiation by activating the MBD3/APOH-mediated fatty acid oxidation axis to promote hepatocellular carcinoma.,2026,10.1097/cm9.0000000000004371,https://pubmed.ncbi.nlm.nih.gov/42754823/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,42458442,Trophoblast cells rewire the epigenetic landscape of vascular smooth muscle cells to modulate plasticity: a regulatory axis disrupted in intrauterine growth restriction.,2026,10.1186/s12964-026-03042-4,https://pubmed.ncbi.nlm.nih.gov/42458442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,40687248,Development and validation of an &lt;i&gt;MBD3/UHRF1&lt;/i&gt; methylation-regulator-based prognostic model for pancreatic cancer survival.,2025,10.21037/tcr-24-1887,https://pubmed.ncbi.nlm.nih.gov/40687248/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,40742009,The role of methyl‑CpG binding domain 3 in seizures and epileptogenesis.,2025,10.55782/ane-2025-2706,https://pubmed.ncbi.nlm.nih.gov/40742009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,42680104,Multicomplex Integrative Structural Modeling of a Human Histone Deacetylase Interactome.,2026,10.1016/j.mcpro.2026.101651,https://pubmed.ncbi.nlm.nih.gov/42680104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,40715296,Interaction and regulatory expression of Polycomb and NuRD complexes in mouse embryonic stem cell under PKC inhibition.,2025,10.1038/s41598-025-12427-3,https://pubmed.ncbi.nlm.nih.gov/40715296/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,40712661,Methyl-CpG-binding domain as a protein interaction partner in promoter regulation and neurodevelopment through evolutionary expanded entanglement.,2025,10.1152/ajpcell.00749.2024,https://pubmed.ncbi.nlm.nih.gov/40712661/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,41980920,PPARα deficiency causes skin dysbiosis and triggers innate immunity in keratinocytes.,2026,10.1038/s41419-026-08640-1,https://pubmed.ncbi.nlm.nih.gov/41980920/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,40413520,LncRNA16 inhibits pyroptosis and promotes platinum resistance in non-small cell lung cancer by sponging miRNA1827 to regulate MBD3/GSDME expression.,2025,10.1186/s12935-025-03812-z,https://pubmed.ncbi.nlm.nih.gov/40413520/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,40408476,PTMA controls cardiomyocyte proliferation and cardiac repair by enhancing STAT3 acetylation.,2025,10.1126/sciadv.adt9446,https://pubmed.ncbi.nlm.nih.gov/40408476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,39876710,c-JUN: a chromatin repressor that limits mesoderm differentiation in human pluripotent stem cells.,2025,10.1093/nar/gkaf001,https://pubmed.ncbi.nlm.nih.gov/39876710/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,37370795,MBD3 as a Potential Biomarker for Colon Cancer: Implications for Epithelial-Mesenchymal Transition (EMT) Pathways.,2023,10.3390/cancers15123185,https://pubmed.ncbi.nlm.nih.gov/37370795/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,39437255,Distinct deregulation trends of transcriptional protein complexes in aging naive T cells.,2025,10.1093/jleuko/qiae231,https://pubmed.ncbi.nlm.nih.gov/39437255/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,38453794,m6A/m1A/m5C-Associated Methylation Alterations and Immune Profile in MDD.,2024,10.1007/s12035-024-04042-6,https://pubmed.ncbi.nlm.nih.gov/38453794/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,39793578,Inactivation of TACC2 epigenetically represses CDKN1A and confers sensitivity to CDK inhibitors.,2025,10.1016/j.medj.2024.12.002,https://pubmed.ncbi.nlm.nih.gov/39793578/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,32181805,Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex-mediated STAT1 downregulation.,2020,10.1084/jem.20191340,https://pubmed.ncbi.nlm.nih.gov/32181805/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,33603141,Role of MBD3-SOX2 axis in residual myeloma following pomalidomide.,2021,10.1038/s41375-021-01145-0,https://pubmed.ncbi.nlm.nih.gov/33603141/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,33014158,Demethylation of HACE1 gene promoter by propofol promotes autophagy of human A549 cells.,2020,10.3892/ol.2020.12143,https://pubmed.ncbi.nlm.nih.gov/33014158/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,36070320,Copper binding leads to increased dynamics in the regulatory N-terminal domain of full-length human copper transporter ATP7B.,2022,10.1371/journal.pcbi.1010074,https://pubmed.ncbi.nlm.nih.gov/36070320/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,37686014,CRISPR-Cas9 Library Screening Identifies Novel Molecular Vulnerabilities in KMT2A-Rearranged Acute Lymphoblastic Leukemia.,2023,10.3390/ijms241713207,https://pubmed.ncbi.nlm.nih.gov/37686014/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3,ENSG00000071655,Unsafe,28899870,Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program.,2017,10.1084/jem.20161827,https://pubmed.ncbi.nlm.nih.gov/28899870/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L1,ENSG00000170948,Unsafe,29533181,NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins.,2018,10.7554/elife.31023,https://pubmed.ncbi.nlm.nih.gov/29533181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L1,ENSG00000170948,Unsafe,19471314,Expression of SNURF-SNRPN upstream transcripts and epigenetic regulatory genes during human spermatogenesis.,2009,10.1038/ejhg.2009.83,https://pubmed.ncbi.nlm.nih.gov/19471314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L1,ENSG00000170948,Unsafe,25881900,MIRA-seq for DNA methylation analysis of CpG islands.,2015,10.2217/epi.15.33,https://pubmed.ncbi.nlm.nih.gov/25881900/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L1,ENSG00000170948,Unsafe,23759032,A novel methyl-binding domain protein enrichment method for identifying genome-wide tissue-specific DNA methylation from nanogram DNA samples.,2013,10.1186/1756-8935-6-17,https://pubmed.ncbi.nlm.nih.gov/23759032/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L1,ENSG00000170948,Unsafe,18942147,"Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse.",2008,10.1002/dvdy.21767,https://pubmed.ncbi.nlm.nih.gov/18942147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L1,ENSG00000170948,Unsafe,28889375,A Versatile Assay for Detection of Aberrant DNA Methylation in Bladder Cancer.,2018,10.1007/978-1-4939-7234-0_3,https://pubmed.ncbi.nlm.nih.gov/28889375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L1,ENSG00000170948,Unsafe,12504854,"MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.",2002,10.1006/geno.2002.7001,https://pubmed.ncbi.nlm.nih.gov/12504854/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L1,ENSG00000170948,Unsafe,18987807,The MIRA method for DNA methylation analysis.,2009,10.1007/978-1-59745-522-0_6,https://pubmed.ncbi.nlm.nih.gov/18987807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L1,ENSG00000170948,Unsafe,23239876,"Unique features of the anti-parallel, heterodimeric coiled-coil interaction between methyl-cytosine binding domain 2 (MBD2) homologues and GATA zinc finger domain containing 2A (GATAD2A/p66α).",2013,10.1074/jbc.m112.431346,https://pubmed.ncbi.nlm.nih.gov/23239876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L1,ENSG00000170948,Unsafe,20304072,DNA methylation profiling using the methylated-CpG island recovery assay (MIRA).,2010,10.1016/j.ymeth.2010.03.004,https://pubmed.ncbi.nlm.nih.gov/20304072/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MBD3L1,ENSG00000170948,Unsafe,15701600,MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.,2005,10.1074/jbc.m413492200,https://pubmed.ncbi.nlm.nih.gov/15701600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,42303965,Sex-differential associations of MC3R p.F45S with human metabolic profile.,2026,10.1111/jne.70214,https://pubmed.ncbi.nlm.nih.gov/42303965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,41992546,Melanocortin 3 Receptors Do Not Specifically Localize to Primary Cilia in Cultured Human and Rodent Neurons.,2026,10.1002/cbf.70216,https://pubmed.ncbi.nlm.nih.gov/41992546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,42893863,Evidence that undernutrition increases AgRP signaling to arcuate kisspeptin neurons in male and female lambs.,2026,10.1262/jrd.2026-073,https://pubmed.ncbi.nlm.nih.gov/42893863/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,41410731,Effect of a partial loss of function MC3R mutation on MC3R+GHSR-1A heterodimer activity and RNF11 regulation.,2026,10.1007/s40618-025-02774-3,https://pubmed.ncbi.nlm.nih.gov/41410731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,42215442,Dual activation of MC3R and MC4R drives weight loss and reduces food intake in male primates with obesity.,2026,10.1038/s41467-026-73372-x,https://pubmed.ncbi.nlm.nih.gov/42215442/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,41935248,Cellular signatures of melanocortin pathway genes across the locus coeruleus.,2026,10.1186/s40478-026-02287-x,https://pubmed.ncbi.nlm.nih.gov/41935248/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,41401256,The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling.,2025,10.1126/scisignal.adu4315,https://pubmed.ncbi.nlm.nih.gov/41401256/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,41386534,Cross-species studies implicate the melanocortin 3 receptor more strongly in the control of pubertal development than energy balance.,2026,10.1016/j.molmet.2025.102301,https://pubmed.ncbi.nlm.nih.gov/41386534/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,41618380,An exploratory microarray analysis of estrogen-mediated gene expression in central pathways that control energy balance in female rats (Rattus norvegicus).,2026,10.1186/s13104-026-07672-2,https://pubmed.ncbi.nlm.nih.gov/41618380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,41751424,Exploring Autosomal Dominant Non-Syndromic Monogenic Obesity: From Genes to Therapy.,2026,10.3390/cimb48020162,https://pubmed.ncbi.nlm.nih.gov/41751424/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,38322156,"Cloning, distribution, and effects of growth regulation of MC3R and MC4R in red crucian carp (Carassius auratus red var.).",2023,10.3389/fendo.2023.1310000,https://pubmed.ncbi.nlm.nih.gov/38322156/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,40247435,Hepatic MC3R is a regulator of lipid droplet autophagy and liver steatosis.,2026,10.1080/15548627.2025.2495224,https://pubmed.ncbi.nlm.nih.gov/40247435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,39718394,Medial hypothalamic MC3R signalling regulates energy rheostasis in adult mice.,2025,10.1113/jp286699,https://pubmed.ncbi.nlm.nih.gov/39718394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,39956805,Melanocortin 3 receptor regulates hepatic autophagy and systemic adiposity.,2025,10.1038/s41467-025-56936-1,https://pubmed.ncbi.nlm.nih.gov/39956805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,42239891,Dependence of energy balance and hypothalamic neuropeptide gene expression on initial tumor load in mice.,2026,10.3389/fonc.2026.1783555,https://pubmed.ncbi.nlm.nih.gov/42239891/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,42074523,The Necessity of POMC and MC3R Analysis in the First-Level Diagnosis of Monogenic Obesity: The Experience of Two Italian Centers.,2026,10.3390/genes17040405,https://pubmed.ncbi.nlm.nih.gov/42074523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,40004532,Neuromolecular Basis of Impaired Conditioned Taste Aversion Acquisition in Valproate-Induced Rat Model of Autism Spectrum Disorder.,2025,10.3390/genes16020203,https://pubmed.ncbi.nlm.nih.gov/40004532/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,39793758,Hypoxia inducible factor-dependent upregulation of Agrp in glomus type I cells of the carotid body.,2025,10.1016/j.molmet.2025.102095,https://pubmed.ncbi.nlm.nih.gov/39793758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,39793740,Pharmacological function of melanocortin-3 receptor in goldfish (Carassius auratus).,2025,10.1016/j.ygcen.2025.114662,https://pubmed.ncbi.nlm.nih.gov/39793740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,41300741,Molecular Characterization of Hypothalamic-Pituitary-Ovarian Axis Regulation in the Manchurian Zokor (&lt;i&gt;Myospalax psilurus&lt;/i&gt;) During Seasonal Estrus.,2025,10.3390/genes16111289,https://pubmed.ncbi.nlm.nih.gov/41300741/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,42340853,Goldilocks-Inspired Design of Mid-Size Macrocycles for Selective Targeting of Human Melanocortin Receptors.,2026,10.1021/acs.jmedchem.6c01074,https://pubmed.ncbi.nlm.nih.gov/42340853/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,40452822,"An improved synthesis of Compound 11, a unique bicyclic melanocortin-3 antagonist.",2025,10.1002/pep2.24385,https://pubmed.ncbi.nlm.nih.gov/40452822/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,41002740,Polymorphism of Melanocortin Receptor Genes-Association with Inflammatory Traits and Diseases.,2025,10.3390/diseases13090305,https://pubmed.ncbi.nlm.nih.gov/41002740/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,36525144,The interaction of MC3R and MC4R with MRAP2a in rainbow trout (Oncorhynchus mykiss).,2023,10.1007/s10695-022-01159-0,https://pubmed.ncbi.nlm.nih.gov/36525144/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,39832483,N-Branched Tricyclic Guanidines as Novel Melanocortin-3 Receptor Agonists and Melanocortin-4 Receptor Antagonists.,2025,10.1021/acs.jmedchem.4c01556,https://pubmed.ncbi.nlm.nih.gov/39832483/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,37804223,Label-Free Quantitative Thermal Proteome Profiling Reveals Target Transcription Factors with Activities Modulated by MC3R Signaling.,2023,10.1021/acs.analchem.3c03643,https://pubmed.ncbi.nlm.nih.gov/37804223/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,37521838,Analysis of real-time PCR Melanocortin 3 (MC3R) gene expression to identify new biomarkers inflammation in tuberculosis.,2022,10.1186/s43042-022-00323-8,https://pubmed.ncbi.nlm.nih.gov/37521838/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,36547499,Molecular cloning and functional characterization of melanocortin-3 receptor in grass carp (Ctenopharyngodon idella).,2023,10.1007/s10695-022-01164-3,https://pubmed.ncbi.nlm.nih.gov/36547499/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,40743628,"Effects of amino acids methionine, lysine, and taurine on feed intake and mRNA expression of appetite-related neuropeptides in layer-type chicks.",2025,10.1016/j.psj.2025.105586,https://pubmed.ncbi.nlm.nih.gov/40743628/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,38951643,Understanding the genetic complexity of puberty timing across the allele frequency spectrum.,2024,10.1038/s41588-024-01798-4,https://pubmed.ncbi.nlm.nih.gov/38951643/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,33886285,"Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput ""Unbiased"" Screening Campaign.",2021,10.1021/acs.jmedchem.0c02041,https://pubmed.ncbi.nlm.nih.gov/33886285/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,35011144,Functional Characterization of Melanocortin-3 Receptor in a Hibernating Cavefish Onychostoma macrolepis.,2021,10.3390/ani12010038,https://pubmed.ncbi.nlm.nih.gov/35011144/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,36291616,Ligands for Melanocortin Receptors: Beyond Melanocyte-Stimulating Hormones and Adrenocorticotropin.,2022,10.3390/biom12101407,https://pubmed.ncbi.nlm.nih.gov/36291616/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,30937899,Associations of the melanocortin 3 receptor C17A + G241A haplotype with body composition and inflammation in African-American adults.,2019,10.1111/ahg.12315,https://pubmed.ncbi.nlm.nih.gov/30937899/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,28363697,Polymorphisms and mutations in the melanocortin-3 receptor and their relation to human obesity.,2017,10.1016/j.bbadis.2017.03.018,https://pubmed.ncbi.nlm.nih.gov/28363697/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MC3R,ENSG00000124089,Unsafe,34890944,Dietary phosphorus level regulates appetite through modulation of gut and hypothalamic expression of anorexigenic genes in broiler chickens.,2022,10.1016/j.psj.2021.101591,https://pubmed.ncbi.nlm.nih.gov/34890944/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,41145521,Sex-specific associations of gene expression with Alzheimer's disease neuropathology and ante-mortem cognitive performance.,2025,10.1038/s41467-025-64525-5,https://pubmed.ncbi.nlm.nih.gov/41145521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,41303216,The Epigenetic Landscape of Borderline Personality Disorder: Insights from a Systematic Review.,2025,10.3390/jcm14228182,https://pubmed.ncbi.nlm.nih.gov/41303216/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,40138663,Unraveling undiagnosed rare disease cases by HiFi long-read genome sequencing.,2025,10.1101/gr.279414.124,https://pubmed.ncbi.nlm.nih.gov/40138663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,40948515,Hypoxia-anoikis-related genes in LUAD: machine learning and RNA sequencing analysis of immune infiltration and therapy response.,2025,10.62347/gqva7530,https://pubmed.ncbi.nlm.nih.gov/40948515/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,40709129,Balancing Nutrition and Osmolality: Risk of Hyperosmolality During Individualized Fortification With Protein Fortifiers in an In Vitro Study.,2025,10.7759/cureus.86602,https://pubmed.ncbi.nlm.nih.gov/40709129/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,37761962,Epigenetic Findings in Twins with Esophageal Atresia.,2023,10.3390/genes14091822,https://pubmed.ncbi.nlm.nih.gov/37761962/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,31846234,MCF2 is linked to a complex perisylvian syndrome and affects cortical lamination.,2020,10.1002/acn3.50949,https://pubmed.ncbi.nlm.nih.gov/31846234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,35164824,"Identification of an SRY-negative 46,XX infertility male with a heterozygous deletion downstream of SOX3 gene.",2022,10.1186/s13039-022-00580-7,https://pubmed.ncbi.nlm.nih.gov/35164824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,36700469,A high level of the long non-coding RNA MCF2L-AS1 is associated with poor prognosis in breast cancer and MCF2L-AS1 activates YAP transcriptional activity to enhance breast cancer proliferation and metastasis.,2022,10.1080/21655979.2022.2074108,https://pubmed.ncbi.nlm.nih.gov/36700469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,29274998,DNA methylation of APBA3 and MCF2 in borderline personality disorder: Potential biomarkers for response to psychotherapy.,2018,10.1016/j.euroneuro.2017.12.010,https://pubmed.ncbi.nlm.nih.gov/29274998/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,30651846,Differential expression of serum proteins in multiple myeloma.,2019,10.3892/etm.2018.7010,https://pubmed.ncbi.nlm.nih.gov/30651846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,29383183,Multi-color RGB marking enables clonality assessment of liver tumors in a murine xenograft model.,2017,10.18632/oncotarget.23312,https://pubmed.ncbi.nlm.nih.gov/29383183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,24367640,Aberrant methylation of gene associated CpG sites occurs in borderline personality disorder.,2013,10.1371/journal.pone.0084180,https://pubmed.ncbi.nlm.nih.gov/24367640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,15683221,Identification of cancer-testis genes expressed by melanoma and soft tissue sarcoma using bioinformatics.,2005,,https://pubmed.ncbi.nlm.nih.gov/15683221/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,24990771,Horizontal gene transfer of a bacterial insect toxin gene into the Epichloë fungal symbionts of grasses.,2014,10.1038/srep05562,https://pubmed.ncbi.nlm.nih.gov/24990771/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,23785489,IL1RAPL1 associated with mental retardation and autism regulates the formation and stabilization of glutamatergic synapses of cortical neurons through RhoA signaling pathway.,2013,10.1371/journal.pone.0066254,https://pubmed.ncbi.nlm.nih.gov/23785489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,30430102,Individualized Fortification Influences the Osmolality of Human Milk.,2018,10.3389/fped.2018.00322,https://pubmed.ncbi.nlm.nih.gov/30430102/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,14680709,"The insecticidal toxin makes caterpillars floppy 2 (Mcf2) shows similarity to HrmA, an avirulence protein from a plant pathogen.",2003,10.1016/s0378-1097(03)00846-2,https://pubmed.ncbi.nlm.nih.gov/14680709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,20479760,Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia.,2011,10.1038/mp.2010.54,https://pubmed.ncbi.nlm.nih.gov/20479760/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,26740066,Does mouse embryo primordial germ cell activation start before implantation as suggested by single-cell transcriptomics dynamics?,2016,10.1093/molehr/gav072,https://pubmed.ncbi.nlm.nih.gov/26740066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,25871779,Systems Biology Modeling of Five Pathways for Regulation and Potent Inhibition of the Anaphase-Promoting Complex (APC/C): Pivotal Roles for MCC and BubR1.,2015,10.1089/omi.2015.0027,https://pubmed.ncbi.nlm.nih.gov/25871779/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,16569686,Genetic characterisation of spontaneous ankylosing arthropathy with unique inheritance from Fas-deficient strains of mice.,2006,10.1136/ard.2005.050526,https://pubmed.ncbi.nlm.nih.gov/16569686/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCF2,ENSG00000101977,Unsafe,12445822,Alternative splicing variants of the human DBL (MCF-2) proto-oncogene.,2002,10.1016/s0006-291x(02)02645-1,https://pubmed.ncbi.nlm.nih.gov/12445822/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,41761192,"MCM10, a novel YAP1/TEAD4 target, drives gastric cancer progression by bridging DNA replication to stemness acquisition.",2026,10.1186/s12943-026-02623-8,https://pubmed.ncbi.nlm.nih.gov/41761192/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,41487926,Bioinformatics Analysis Reveals that Minichromosome Maintenance 10 Replication Initiation Factor Is a Possible Prognostic Marker for Patients With Adrenocortical Carcinoma.,2026,10.21873/cdp.10503,https://pubmed.ncbi.nlm.nih.gov/41487926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,42777936,MCM10 modulates lipid metabolic reprogramming via the USP7-FASN axis to accelerate renal cell carcinoma progression.,2026,10.1016/j.canlet.2026.218842,https://pubmed.ncbi.nlm.nih.gov/42777936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,41921256,"Expression of MCM2, MCM4, and MCM10 in hepatocellular carcinoma based on bioinformatic analyses and their predictive value for postoperative recurrence: An initial model development study.",2026,10.1016/j.suronc.2026.102410,https://pubmed.ncbi.nlm.nih.gov/41921256/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,41026211,High MCM10 expression mediates TMZ resistance and promotes the progression of glioma.,2025,10.1007/s00280-025-04807-3,https://pubmed.ncbi.nlm.nih.gov/41026211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,40750706,Targeting MCM10 disrupts cancer stemness and counteracts sorafenib resistance in hepatocellular carcinoma.,2025,10.1038/s41417-025-00946-0,https://pubmed.ncbi.nlm.nih.gov/40750706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,41964694,Correction: High MCM10 expression mediates TMZ resistance and promotes the progression of glioma.,2026,10.1007/s00280-026-04873-1,https://pubmed.ncbi.nlm.nih.gov/41964694/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,40779443,Targeting the &lt;i&gt;MCM10/p53/p21/CCND1&lt;/i&gt; Axis in Colorectal Cancer: Evaluating the Therapeutic Potential of Ultrasound.,2026,10.1177/10849785251364091,https://pubmed.ncbi.nlm.nih.gov/40779443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,39551114,MCM10: A potential biomarker for cervical cancer and precancerous lesions.,2025,10.1016/j.gene.2024.149103,https://pubmed.ncbi.nlm.nih.gov/39551114/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,42470639,SUDS3 nuclear condensates decelerate DNA replication and safeguard genome stability.,2026,10.1016/j.celrep.2026.117713,https://pubmed.ncbi.nlm.nih.gov/42470639/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,39999840,An epitope-directed mRNA vaccine inhibits tumor metastasis through the blockade of MICA/B α1/2 shedding.,2025,10.1016/j.xcrm.2025.101981,https://pubmed.ncbi.nlm.nih.gov/39999840/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,41276527,AtMCM10 facilitates SDSA-mediated intermolecular homologous recombination repair via liquid-liquid phase separation in DNA damage response.,2025,10.1038/s41467-025-66705-9,https://pubmed.ncbi.nlm.nih.gov/41276527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,40065065,The m6A reader IGF2BP3 promotes HCC progression by enhancing MCM10 stability.,2025,10.1038/s41598-025-93062-w,https://pubmed.ncbi.nlm.nih.gov/40065065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,37848534,"MCM10, a potential diagnostic, immunological, and prognostic biomarker in pan-cancer.",2023,10.1038/s41598-023-44946-2,https://pubmed.ncbi.nlm.nih.gov/37848534/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,39364137,S-CDK-regulated bipartite interaction of Mcm10 with MCM is essential for DNA replication.,2024,10.3389/fcell.2024.1420033,https://pubmed.ncbi.nlm.nih.gov/39364137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,38262603,A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells.,2024,10.1098/rsob.230407,https://pubmed.ncbi.nlm.nih.gov/38262603/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,40255404,Clinical potential and experimental validation of prognostic genes in hepatocellular carcinoma revealed by risk modeling utilizing single cell and transcriptome constructs.,2025,10.3389/fimmu.2025.1541252,https://pubmed.ncbi.nlm.nih.gov/40255404/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,38074804,Immune modulation and prognostic significance of MCM10 in pan-cancer: a comprehensive analysis.,2023,,https://pubmed.ncbi.nlm.nih.gov/38074804/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,40651967,O-GlcNAcylation of METTL3 drives hepatocellular carcinoma progression by upregulating MCM10 expression in an m6A-IGF2BP3-dependent manner.,2025,10.1038/s41419-025-07844-1,https://pubmed.ncbi.nlm.nih.gov/40651967/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,42859650,Somatic Mutation-Informed Transcriptional Architecture of Hepatocellular Carcinoma: A Multiomics Study Centered on &lt;i&gt;TP53&lt;/i&gt;.,2026,10.1155/humu/2377057,https://pubmed.ncbi.nlm.nih.gov/42859650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,39627228,Stabilization of expandable DNA repeats by the replication factor Mcm10 promotes cell viability.,2024,10.1038/s41467-024-54977-6,https://pubmed.ncbi.nlm.nih.gov/39627228/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,39528802,Discovery of key molecular signatures for diagnosis and therapies of glioblastoma by combining supervised and unsupervised learning approaches.,2024,10.1038/s41598-024-79391-2,https://pubmed.ncbi.nlm.nih.gov/39528802/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,37860833,Activation of Glycolysis by MCM10 Increases Stemness and Paclitaxel Resistance in Gastric Cancer Cells.,2023,10.5152/tjg.2023.23169,https://pubmed.ncbi.nlm.nih.gov/37860833/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,37246638,MCM10: An effective treatment target and a prognostic biomarker in patients with uterine corpus endometrial carcinoma.,2023,10.1111/jcmm.17772,https://pubmed.ncbi.nlm.nih.gov/37246638/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,41594403,Integrated Transcriptomics and Targeted Metabolomics Approaches: Comparative Analysis of the Ileum in Neonatal Piglets with Different Birth Weight.,2026,10.3390/ani16020213,https://pubmed.ncbi.nlm.nih.gov/41594403/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,35664337,MCM10 is a Prognostic Biomarker and Correlated With Immune Checkpoints in Ovarian Cancer.,2022,10.3389/fgene.2022.864578,https://pubmed.ncbi.nlm.nih.gov/35664337/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,40231067,RAD51 expression and prognostic impact in patients with stomach adenocarcinoma.,2025,10.7717/peerj.19179,https://pubmed.ncbi.nlm.nih.gov/40231067/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,38870259,Prognostic implication and immunotherapy response prediction of a novel ubiquitination-related gene signature in liver cancer.,2024,10.18632/aging.205926,https://pubmed.ncbi.nlm.nih.gov/38870259/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,40792151,Identification and validation of hub genes for kidney renal clear cell carcinoma treated with metformin and everolimus combination therapy.,2025,10.21037/tcr-2025-277,https://pubmed.ncbi.nlm.nih.gov/40792151/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,38809096,Replication Stress in Activated Human NK Cells Induces Sensitivity to Apoptosis.,2024,10.4049/jimmunol.2300843,https://pubmed.ncbi.nlm.nih.gov/38809096/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,35056094,BI-2536 Promotes Neuroblastoma Cell Death via Minichromosome Maintenance Complex Components 2 and 10.,2021,10.3390/ph15010037,https://pubmed.ncbi.nlm.nih.gov/35056094/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,38982858,Identification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function.,2024,10.1158/1535-7163.mct-23-0904,https://pubmed.ncbi.nlm.nih.gov/38982858/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCM10,ENSG00000065328,Unsafe,36499614,Identification of Novel Hub Genes Associated with Psoriasis Using Integrated Bioinformatics Analysis.,2022,10.3390/ijms232315286,https://pubmed.ncbi.nlm.nih.gov/36499614/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCMDC2,ENSG00000178460,Unsafe,41820312,A novel loss-of-function mutation in MCMDC2 is associated with male infertility.,2026,10.1038/s41439-026-00342-6,https://pubmed.ncbi.nlm.nih.gov/41820312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCMDC2,ENSG00000178460,Unsafe,39789727,Novel biallelic MCMDC2 variants were associated with meiotic arrest and nonobstructive azoospermia.,2025,10.4103/aja202495,https://pubmed.ncbi.nlm.nih.gov/39789727/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCMDC2,ENSG00000178460,Unsafe,40037983,Paired copy number variation analysis in siblings discordant for familial Parkinson's disease.,2025,10.1177/00045632251328130,https://pubmed.ncbi.nlm.nih.gov/40037983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCMDC2,ENSG00000178460,Unsafe,35172124,Whole-exome sequencing improves the diagnosis and care of men with non-obstructive azoospermia.,2022,10.1016/j.ajhg.2022.01.011,https://pubmed.ncbi.nlm.nih.gov/35172124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCMDC2,ENSG00000178460,Unsafe,27760146,Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein.,2016,10.1371/journal.pgen.1006393,https://pubmed.ncbi.nlm.nih.gov/27760146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCMDC2,ENSG00000178460,Unsafe,35990266,Effects of chronic hypoxia on the gene expression profile in the embryonic heart in three Chinese indigenous chicken breeds (Gallus gallus).,2022,10.3389/fvets.2022.942159,https://pubmed.ncbi.nlm.nih.gov/35990266/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCMDC2,ENSG00000178460,Unsafe,36732629,Landscape of pathogenic mutations in premature ovarian insufficiency.,2023,10.1038/s41591-022-02194-3,https://pubmed.ncbi.nlm.nih.gov/36732629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCMDC2,ENSG00000178460,Unsafe,27986806,Repair of Meiotic DNA Breaks and Homolog Pairing in Mouse Meiosis Requires a Minichromosome Maintenance (MCM) Paralog.,2017,10.1534/genetics.116.196808,https://pubmed.ncbi.nlm.nih.gov/27986806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCMDC2,ENSG00000178460,Unsafe,34413003,Detection of novel fusion genes by next-generation sequencing-based targeted RNA sequencing analysis in adenoid cystic carcinoma of head and neck.,2021,10.1016/j.oooo.2021.03.020,https://pubmed.ncbi.nlm.nih.gov/34413003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,42812823,ABRAXAS1-HELQ is a candidate class-matched reference chimeric RNA and contributes to prostate cell motility through MCOLN2.,2026,10.3389/fonc.2026.1935441,https://pubmed.ncbi.nlm.nih.gov/42812823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,42474027,A Programmable Calcification Nanoplatform for Loco-Regional Calcification-Immune Hepatocellular Carcinoma Therapy.,2026,10.1002/advs.76642,https://pubmed.ncbi.nlm.nih.gov/42474027/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,42485795,Ion channel TRPML2 (MCOLN2) promotes ovarian cancer metastasis and chemoresistance.,2026,10.1016/j.bbrc.2026.154288,https://pubmed.ncbi.nlm.nih.gov/42485795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,40332161,Transient Receptor Potential Channels in Prostate Cancer: Associations with ERG Fusions and Survival.,2025,10.3390/ijms26083639,https://pubmed.ncbi.nlm.nih.gov/40332161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,38383918,Genomic evidence for the suitability of Göttingen Minipigs with a rare seizure phenotype as a model for human epilepsy.,2024,10.1007/s10048-024-00750-2,https://pubmed.ncbi.nlm.nih.gov/38383918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,38306561,"Role of PAX6, TRPA1, BCL11B, MCOLN2, CUX1, EMX1 in colorectal cancer and osteosarcoma.",2024,10.1097/md.0000000000037056,https://pubmed.ncbi.nlm.nih.gov/38306561/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,42567485,Tape-strip transcriptomics identify immune signatures in cutaneous T-cell lymphoma distinct from benign inflammatory skin diseases.,2026,10.1016/j.jaci.2026.07.019,https://pubmed.ncbi.nlm.nih.gov/42567485/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,41430707,"A novel Bi-Allelic pathogenic MCOLN1 variant underlying mucolipidosis type IV in an Iranian family: clinical, genetic, and molecular dynamics-based structural analysis.",2025,10.1186/s12920-025-02271-9,https://pubmed.ncbi.nlm.nih.gov/41430707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,40325078,DCMS analysis revealed differential selection signatures in the transboundary Sahiwal cattle for major economic traits.,2025,10.1038/s41598-025-93021-5,https://pubmed.ncbi.nlm.nih.gov/40325078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,34548638,Endolysosomal ion channel MCOLN2 (Mucolipin-2) promotes prostate cancer progression via IL-1β/NF-κB pathway.,2021,10.1038/s41416-021-01537-0,https://pubmed.ncbi.nlm.nih.gov/34548638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,38879491,Modulation of anti-cardiac fibrosis immune responses by changing M2 macrophages into M1 macrophages.,2024,10.1186/s10020-024-00858-z,https://pubmed.ncbi.nlm.nih.gov/38879491/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,37228749,Human variation impacting &lt;i&gt;MCOLN2&lt;/i&gt; restricts &lt;i&gt;Salmonella&lt;/i&gt; Typhi replication by magnesium deprivation.,2023,10.1016/j.xgen.2023.100290,https://pubmed.ncbi.nlm.nih.gov/37228749/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,38829671,The Aging Lacrimal Gland of Female C57BL/6J Mice Exhibits Multinucleate Macrophage Infiltration Associated With Lipid Dysregulation.,2024,10.1167/iovs.65.6.1,https://pubmed.ncbi.nlm.nih.gov/38829671/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,38158807,Transcriptomic profile of the mechanosensitive ion channelome in human cardiac fibroblasts.,2023,10.1177/15353702231218488,https://pubmed.ncbi.nlm.nih.gov/38158807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,38749178,Biogenic selenium nanoparticles alleviate intestinal barrier injury in mice through TBC1D15/Fis1/Rab7 pathway.,2024,10.1016/j.biopha.2024.116740,https://pubmed.ncbi.nlm.nih.gov/38749178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,35625048,TRP Family Genes Are Differently Expressed and Correlated with Immune Response in Glioma.,2022,10.3390/brainsci12050662,https://pubmed.ncbi.nlm.nih.gov/35625048/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,37144827,Biogenic selenium nanoparticles alleviate intestinal epithelial barrier injury by regulating mitochondria-lysosome crosstalk.,2023,10.1039/d2fo03992c,https://pubmed.ncbi.nlm.nih.gov/37144827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,29382735,Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses.,2018,10.1128/mbio.02314-17,https://pubmed.ncbi.nlm.nih.gov/29382735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,33387576,Identification of four methylation-driven genes as candidate biomarkers for monitoring single-walled carbon nanotube-induced malignant transformation of the lung.,2021,10.1016/j.taap.2020.115391,https://pubmed.ncbi.nlm.nih.gov/33387576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,27259261,CDH1 rs9929218 variant at 16q22.1 contributes to colorectal cancer susceptibility.,2016,10.18632/oncotarget.9758,https://pubmed.ncbi.nlm.nih.gov/27259261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,30018046,Mechanisms by Which Dendritic Cells Present Tumor Microparticle Antigens to CD8+ T Cells.,2018,10.1158/2326-6066.cir-17-0716,https://pubmed.ncbi.nlm.nih.gov/30018046/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,26336837,The mucolipin-2 (TRPML2) ion channel: a tissue-specific protein crucial to normal cell function.,2016,10.1007/s00424-015-1732-2,https://pubmed.ncbi.nlm.nih.gov/26336837/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,26308964,Integrated methylome and transcriptome analysis reveals novel regulatory elements in pediatric acute lymphoblastic leukemia.,2015,10.1080/15592294.2015.1078050,https://pubmed.ncbi.nlm.nih.gov/26308964/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCOLN2,ENSG00000153898,Unsafe,21478870,A diverse range of gene products are effectors of the type I interferon antiviral response.,2011,10.1038/nature09907,https://pubmed.ncbi.nlm.nih.gov/21478870/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,42694451,Potentially Deleterious Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) in the Human &lt;i&gt;MCPH1&lt;/i&gt; Gene: Systematic In Silico Predictions and Implications for Structure and Function.,2026,10.1155/humu/3241521,https://pubmed.ncbi.nlm.nih.gov/42694451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,42793752,&lt;i&gt;MCPH1&lt;/i&gt; and DNA Damage Response Pathway Genes as Candidate Susceptibility Loci in Hereditary Breast Cancer.,2026,10.3390/diagnostics16182967,https://pubmed.ncbi.nlm.nih.gov/42793752/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,41931484,Differential sensitivity of MCPH1- and BRCA2-deficient cancer cells to PARP-1 inhibition.,2026,10.1371/journal.pone.0345514,https://pubmed.ncbi.nlm.nih.gov/41931484/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,42240786,Editorial Expression of Concern: Frequent Alterations of MCPH1 and ATM are Associated with Primary Breast Carcinoma: Clinical and Prognostic Implications.,2026,10.1245/s10434-026-19971-w,https://pubmed.ncbi.nlm.nih.gov/42240786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,41403951,Prognostic and therapeutic implications of disulfidptosis-related genes in multiple myeloma.,2025,10.3389/fimmu.2025.1652179,https://pubmed.ncbi.nlm.nih.gov/41403951/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,41074654,What the fruit fly can tell us about autosomal recessive primary microcephaly.,2025,10.1080/19336934.2025.2572866,https://pubmed.ncbi.nlm.nih.gov/41074654/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,42182752,Identification and validation of prognostic genes related to mitochondrial dynamics and mitochondrial autophagy in esophageal squamous cell carcinoma.,2026,10.21037/jtd-2026-1-0322,https://pubmed.ncbi.nlm.nih.gov/42182752/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,38818167,Functional analysis of a novel intronic variant of MCPH1 with autosomal recessive primary microcephaly.,2024,10.1016/j.heliyon.2024.e30285,https://pubmed.ncbi.nlm.nih.gov/38818167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,39775836,Threonine and tyrosine kinase (TTK) mRNA and protein expression in breast cancer; prognostic significance in the neoadjuvant setting.,2025,10.1111/his.15399,https://pubmed.ncbi.nlm.nih.gov/39775836/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,39280843,Generation and analysis of mouse embryonic stem cells with knockout of the Mcph1 (microcephalin) gene.,2024,10.18699/vjgb-24-55,https://pubmed.ncbi.nlm.nih.gov/39280843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,41096937,Familial Molecular Burden in Autism Spectrum Disorder: A Next-Generation Sequencing Study of Polish Affected Families.,2025,10.3390/ijms26199672,https://pubmed.ncbi.nlm.nih.gov/41096937/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,38731817,Microcephaly Gene Mcph1 Deficiency Induces p19ARF-Dependent Cell Cycle Arrest and Senescence.,2024,10.3390/ijms25094597,https://pubmed.ncbi.nlm.nih.gov/38731817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,38463519,The analyses of human MCPH1 DNA repair machinery and genetic variations.,2024,10.1515/med-2024-0917,https://pubmed.ncbi.nlm.nih.gov/38463519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,42511094,Genetic Ancestry and Genome-Wide Association Study Combined with Functional Enrichment Analyses Reveal Candidate Genes for Body Conformation Traits in Hexi Cattle.,2026,10.3390/ani16142216,https://pubmed.ncbi.nlm.nih.gov/42511094/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,36845691,The emerging role of MCPH1/BRIT1 in carcinogenesis.,2023,10.3389/fonc.2023.1047588,https://pubmed.ncbi.nlm.nih.gov/36845691/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,39885205,TOP2A inhibition and its cellular effects related to cell cycle checkpoint adaptation pathway.,2025,10.1038/s41598-025-87895-8,https://pubmed.ncbi.nlm.nih.gov/39885205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,38605277,"Mcph1, mutated in primary microcephaly, is also crucial for erythropoiesis.",2024,10.1038/s44319-024-00123-8,https://pubmed.ncbi.nlm.nih.gov/38605277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,36078123,The Central Domain of MCPH1 Controls Development of the Cerebral Cortex and Gonads in Mice.,2022,10.3390/cells11172715,https://pubmed.ncbi.nlm.nih.gov/36078123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,35456440,MCPH1: A Novel Case Report and a Review of the Literature.,2022,10.3390/genes13040634,https://pubmed.ncbi.nlm.nih.gov/35456440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,33542216,The N-terminal BRCT domain determines MCPH1 function in brain development and fertility.,2021,10.1038/s41419-021-03406-3,https://pubmed.ncbi.nlm.nih.gov/33542216/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,40009290,Population-based study of recurrent DNA damage response gene variants in breast cancer cases.,2025,10.1007/s10549-025-07634-5,https://pubmed.ncbi.nlm.nih.gov/40009290/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,38845982,A telomere-related gene risk model for predicting prognosis and treatment response in acute myeloid leukemia.,2024,10.1016/j.heliyon.2024.e31705,https://pubmed.ncbi.nlm.nih.gov/38845982/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,35053391,Multifaceted Microcephaly-Related Gene MCPH1.,2022,10.3390/cells11020275,https://pubmed.ncbi.nlm.nih.gov/35053391/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,40941673,Genetic Variants Associated with Breast Cancer Are Detected by Whole-Exome Sequencing in Vietnamese Patients.,2025,10.3390/diagnostics15172187,https://pubmed.ncbi.nlm.nih.gov/40941673/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,36561322,Construction and validation of a novel cuproptosis-related long noncoding RNA signature for predicting the outcome of prostate cancer.,2022,10.3389/fgene.2022.976850,https://pubmed.ncbi.nlm.nih.gov/36561322/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,35736544,Validation of a Novel Double Control Quantitative Copy Number PCR Method to Quantify Off-Target Transgene Integration after CRISPR-Induced DNA Modification.,2022,10.3390/mps5030043,https://pubmed.ncbi.nlm.nih.gov/35736544/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,36550402,NSD1 gene evolves under episodic selection within primates and mutations of specific exons in humans cause Sotos syndrome.,2022,10.1186/s12864-022-09071-w,https://pubmed.ncbi.nlm.nih.gov/36550402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,34090518,The REASON score: an epigenetic and clinicopathologic score to predict risk of poor survival in patients with early stage oral squamous cell carcinoma.,2021,10.1186/s40364-021-00292-x,https://pubmed.ncbi.nlm.nih.gov/34090518/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,27502025,TALEN-based generation of a cynomolgus monkey disease model for human microcephaly.,2016,10.1038/cr.2016.93,https://pubmed.ncbi.nlm.nih.gov/27502025/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,23516444,Mcph1-deficient mice reveal a role for MCPH1 in otitis media.,2013,10.1371/journal.pone.0058156,https://pubmed.ncbi.nlm.nih.gov/23516444/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,23117476,Frequent alterations of MCPH1 and ATM are associated with primary breast carcinoma: clinical and prognostic implications.,2013,10.1245/s10434-012-2715-6,https://pubmed.ncbi.nlm.nih.gov/23117476/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,23472065,Primary microcephaly gene MCPH1 shows signatures of tumor suppressors and is regulated by miR-27a in oral squamous cell carcinoma.,2013,10.1371/journal.pone.0054643,https://pubmed.ncbi.nlm.nih.gov/23472065/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,23908141,Interaction of polymorphisms in mitotic regulator genes with cigarette smoking and pancreatic cancer risk.,2013,10.1002/mc.22037,https://pubmed.ncbi.nlm.nih.gov/23908141/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,30683929,Multiple genomic copy number variants associated with periventricular nodular heterotopia indicate extreme genetic heterogeneity.,2019,10.1038/s41431-019-0335-3,https://pubmed.ncbi.nlm.nih.gov/30683929/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,18204051,A common SNP of MCPH1 is associated with cranial volume variation in Chinese population.,2008,10.1093/hmg/ddn021,https://pubmed.ncbi.nlm.nih.gov/18204051/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MCPH1,ENSG00000147316,Unsafe,12046007,"Identification of microcephalin, a protein implicated in determining the size of the human brain.",2002,10.1086/341283,https://pubmed.ncbi.nlm.nih.gov/12046007/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,41570816,MDGA2 homozygous loss-of-function variants cause developmental and epileptic encephalopathy.,2026,10.1016/j.ajhg.2025.12.015,https://pubmed.ncbi.nlm.nih.gov/41570816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,42521817,The genetic architecture of fibromyalgia across 2.5 million individuals.,2026,10.1038/s41591-026-04492-6,https://pubmed.ncbi.nlm.nih.gov/42521817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,40316130,EphB2 receptor tyrosine kinase-mediated excitatory synaptic functions are negatively modulated by MDGA2.,2025,10.1016/j.pneurobio.2025.102772,https://pubmed.ncbi.nlm.nih.gov/40316130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,42411868,Genomic Copy Number Variants Associated With Strabismus and Amblyopia in the All of Us Research Program.,2026,10.1167/iovs.67.8.21,https://pubmed.ncbi.nlm.nih.gov/42411868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,42814113,"Shared genetic architecture across social disconnection, social disadvantage, and psychiatric and neurodevelopmental traits.",2026,10.1007/s00406-026-02397-6,https://pubmed.ncbi.nlm.nih.gov/42814113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,40168357,Mdga2 deficiency leads to an aberrant activation of BDNF/TrkB signaling that underlies autism-relevant synaptic and behavioral changes in mice.,2025,10.1371/journal.pbio.3003047,https://pubmed.ncbi.nlm.nih.gov/40168357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,41622251,Inflammation-induced impairment of synaptic plasticity accelerates atherosclerosis co-depression disease: insights from bioinformatics analysis and transcriptomics.,2026,10.1186/s13578-026-01535-w,https://pubmed.ncbi.nlm.nih.gov/41622251/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,39816685,RPS23RG1 inhibits SORT1-mediated lysosomal degradation of MDGA2 to protect against autism.,2025,10.7150/thno.100451,https://pubmed.ncbi.nlm.nih.gov/39816685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,38321347,"MDGA2 Constrains Glutamatergic Inputs Selectively onto CA1 Pyramidal Neurons to Optimize Neural Circuits for Plasticity, Memory, and Social Behavior.",2024,10.1007/s12264-023-01171-1,https://pubmed.ncbi.nlm.nih.gov/38321347/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,41124857,MDGAs as synaptic suppressors with implications in neurodevelopmental disorders.,2025,10.1016/j.conb.2025.103130,https://pubmed.ncbi.nlm.nih.gov/41124857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,38900791,MDGAs perform activity-dependent synapse type-specific suppression via distinct extracellular mechanisms.,2024,10.1073/pnas.2322978121,https://pubmed.ncbi.nlm.nih.gov/38900791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,39284869,Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABA&lt;sub&gt;A&lt;/sub&gt;Rs and cytosolic gephyrin aggregation.,2024,10.1038/s42003-024-06789-z,https://pubmed.ncbi.nlm.nih.gov/39284869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,41483448,Exploring molecular mechanisms of radioactive iodine therapy in thyroid cancer using single-cell RNA sequencing data.,2026,10.1007/s12672-025-04317-x,https://pubmed.ncbi.nlm.nih.gov/41483448/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,37499910,Early postnatal development of the MDGA2+/- mouse model of synaptic dysfunction.,2023,10.1016/j.bbr.2023.114590,https://pubmed.ncbi.nlm.nih.gov/37499910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,40506516,"Association between methylation quantitative trait loci and colorectal cancer risk, survival and cancer recurrence.",2025,10.1038/s41416-025-03064-8,https://pubmed.ncbi.nlm.nih.gov/40506516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,37876438,A transcriptome study of p53-pathway related prognostic gene signature set in bladder cancer.,2023,10.1016/j.heliyon.2023.e21058,https://pubmed.ncbi.nlm.nih.gov/37876438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,38830559,Potential involvement of KANK1 haploinsufficiency in centrosome aberrations.,2024,10.1016/j.bbagen.2024.130648,https://pubmed.ncbi.nlm.nih.gov/38830559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,32808443,The effect of background strain on the behavioral phenotypes of the MDGA2+/- mouse model of autism spectrum disorder.,2021,10.1111/gbb.12696,https://pubmed.ncbi.nlm.nih.gov/32808443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,37030103,Peripheral blood mononuclear cell derived biomarker detection using eXplainable Artificial Intelligence (XAI) provides better diagnosis of breast cancer.,2023,10.1016/j.compbiolchem.2023.107867,https://pubmed.ncbi.nlm.nih.gov/37030103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,38576019,Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma.,2024,10.1186/s12967-024-04919-z,https://pubmed.ncbi.nlm.nih.gov/38576019/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,35992141,Identification of the alpha linolenic acid metabolism-related signature associated with prognosis and the immune microenvironment in nasopharyngeal carcinoma.,2022,10.3389/fendo.2022.968984,https://pubmed.ncbi.nlm.nih.gov/35992141/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,27565350,Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts.,2016,10.1016/j.cell.2016.07.041,https://pubmed.ncbi.nlm.nih.gov/27565350/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,25162227,"Laf4/Aff3, a gene involved in intellectual disability, is required for cellular migration in the mouse cerebral cortex.",2014,10.1371/journal.pone.0105933,https://pubmed.ncbi.nlm.nih.gov/25162227/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,22445761,Genome-wide association study of SSRI/SNRI-induced sexual dysfunction in a Japanese cohort with major depression.,2012,10.1016/j.psychres.2012.01.023,https://pubmed.ncbi.nlm.nih.gov/22445761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,19557195,Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes.,2009,10.1371/journal.pgen.1000536,https://pubmed.ncbi.nlm.nih.gov/19557195/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,24429156,Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.,2013,10.1016/s2213-2600(13)70045-6,https://pubmed.ncbi.nlm.nih.gov/24429156/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDGA2,ENSG00000139915,Unsafe,19997561,Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE).,2009,10.1371/journal.pone.0008037,https://pubmed.ncbi.nlm.nih.gov/19997561/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDH1B,ENSG00000138400,Unsafe,41519486,OX-LDL causes vascular endothelial injury by interfering with the CREB1-MDH1B-malate axis.,2026,10.1016/j.freeradbiomed.2025.12.051,https://pubmed.ncbi.nlm.nih.gov/41519486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDH1B,ENSG00000138400,Unsafe,40145662,A cross-tissue transcriptome-wide association study reveals novel susceptibility genes for erectile dysfunction.,2026,10.1111/andr.70034,https://pubmed.ncbi.nlm.nih.gov/40145662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDH1B,ENSG00000138400,Unsafe,39037390,Genetics of MDH in humans.,2024,10.1042/ebc20230078,https://pubmed.ncbi.nlm.nih.gov/39037390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDH1B,ENSG00000138400,Unsafe,36968582,The construction and analysis of tricarboxylic acid cycle related prognostic model for cervical cancer.,2023,10.3389/fgene.2023.1092276,https://pubmed.ncbi.nlm.nih.gov/36968582/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MDH1B,ENSG00000138400,Unsafe,34246305,"Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis.",2021,10.1186/s13075-021-02570-3,https://pubmed.ncbi.nlm.nih.gov/34246305/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,42517142,Case Report: A novel &lt;i&gt;de novo&lt;/i&gt; heterozygous truncating mutation in &lt;i&gt;MED12L&lt;/i&gt; identified in a Chinese autistic boy.,2026,10.3389/fpsyt.2026.1824663,https://pubmed.ncbi.nlm.nih.gov/42517142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,42388386,PASNA syndrome with overlapping &lt;i&gt;CACNA1D&lt;/i&gt; and &lt;i&gt;MED12L&lt;/i&gt; variants: expanding the spectrum.,2026,10.1210/jcemcr/luag131,https://pubmed.ncbi.nlm.nih.gov/42388386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,40838347,Case Series of Nizon-Isidor Syndrome by Heterozygous Variants in MED12L With Further Evidence of Mitotic Instability in One Case With Diploid-Triploid Mosaicism.,2026,10.1002/ajmg.a.64233,https://pubmed.ncbi.nlm.nih.gov/40838347/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,41465117,"Genetic, Clinical and Neuroradiological Spectrum of MED-Related Disorders: An Updated Review.",2025,10.3390/genes16121444,https://pubmed.ncbi.nlm.nih.gov/41465117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,42421762,T-cell lymphoma of the breast and ovary presenting as a second malignant neoplasm in a pediatric leukemia survivor: A case report and literature review.,2026,10.1177/20363613261443114,https://pubmed.ncbi.nlm.nih.gov/42421762/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,41964436,The subunit composition of the mammalian Mediator complex is not conserved in all vertebrates: Insights from evolutionary plasticity of fish genomes.,2026,10.1002/pro.70566,https://pubmed.ncbi.nlm.nih.gov/41964436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,41023835,Functional characterization of the MED12 p.Arg1138Trp variant in females: implications for neural development and disease mechanism.,2025,10.1186/s10020-025-01365-5,https://pubmed.ncbi.nlm.nih.gov/41023835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,40919805,Heterozygous Med13l mice recapitulate a developmental growth delay and craniofacial anomalies seen in MED13L syndrome.,2026,10.1002/dvdy.70079,https://pubmed.ncbi.nlm.nih.gov/40919805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,40924252,Landscape genomics analysis reveals the genetic basis underlying cashmere goats and dairy goats adaptation to frigid environments.,2025,10.1007/s44154-025-00254-5,https://pubmed.ncbi.nlm.nih.gov/40924252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,39166955,Unraveling the genetic susceptibility of irritable bowel syndrome: integrative genome-wide analyses in 845 492 individuals: a diagnostic study.,2025,10.1097/js9.0000000000002039,https://pubmed.ncbi.nlm.nih.gov/39166955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,40774060,Genetic characteristics of primary bone marrow large B-cell lymphoma.,2025,10.1016/j.prp.2025.156157,https://pubmed.ncbi.nlm.nih.gov/40774060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,40062727,A Novel Prognostic Risk-Scoring Model Based on RAS Gene-Associated Cluster in Pediatric Acute Myeloid Leukemia.,2025,10.1002/cam4.70716,https://pubmed.ncbi.nlm.nih.gov/40062727/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,38602606,"Mediator kinase module proteins, genetic alterations and expression of super-enhancer regulated genes in colorectal cancer.",2024,10.1007/s43440-024-00589-2,https://pubmed.ncbi.nlm.nih.gov/38602606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,31155615,"Variants in MED12L, encoding a subunit of the mediator kinase module, are responsible for intellectual disability associated with transcriptional defect.",2019,10.1038/s41436-019-0557-3,https://pubmed.ncbi.nlm.nih.gov/31155615/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,35983817,The Results of Peritoneal Re-Approximation Methods on Symptomatic Lymphocele Formation in Robot-Assisted Laparoscopic Radical Prostatectomy and Extended Pelvic Lymphadenectomy.,2022,10.56434/j.arch.esp.urol.20227505.65,https://pubmed.ncbi.nlm.nih.gov/35983817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,34089082,SNPs at 3'UTR of APOL1 and miR-6741-3p target sites associated with kidney diseases more susceptible to SARS-COV-2 infection: in silco and in vitro studies.,2021,10.1007/s00335-021-09880-6,https://pubmed.ncbi.nlm.nih.gov/34089082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,30905399,"De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder.",2019,10.1016/j.ajhg.2019.02.006,https://pubmed.ncbi.nlm.nih.gov/30905399/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,34034702,DNA methylation signatures associated with prognosis of gastric cancer.,2021,10.1186/s12885-021-08389-0,https://pubmed.ncbi.nlm.nih.gov/34034702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,34899750,A Co-Association Network Analysis Reveals Putative Regulators for Health-Related Traits in Pigs.,2021,10.3389/fimmu.2021.784978,https://pubmed.ncbi.nlm.nih.gov/34899750/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,32934007,The extent of cyclin C promoter occupancy directs changes in stress-dependent transcription.,2020,10.1074/jbc.ra120.015215,https://pubmed.ncbi.nlm.nih.gov/32934007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,33204752,Genetic Determinants of Antibody-Mediated Immune Responses to Infectious Diseases Agents: A Genome-Wide and HLA Association Study.,2020,10.1093/ofid/ofaa450,https://pubmed.ncbi.nlm.nih.gov/33204752/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,33740484,Effects of exposure to urban particulate matter SRM 1648a during pregnancy on the neurobehavioral development of offspring mice.,2021,10.1016/j.ecoenv.2021.112142,https://pubmed.ncbi.nlm.nih.gov/33740484/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,24444404,Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines.,2014,10.2217/pgs.13.213,https://pubmed.ncbi.nlm.nih.gov/24444404/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED12L,ENSG00000144893,Unsafe,24668645,A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease.,2014,10.1158/1078-0432.ccr-14-0205,https://pubmed.ncbi.nlm.nih.gov/24668645/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,42762395,"ABCC9/SUR2 has a Complex Expression Pattern in Human Brain Gliovascular Unit Cells, Including Astrocytes.",2026,10.1007/s12031-026-02603-z,https://pubmed.ncbi.nlm.nih.gov/42762395/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,42397736,Glioblastoma stem cell growth requires DOT1L-MED23 control of enhancer accessibility.,2026,10.1016/j.celrep.2026.117647,https://pubmed.ncbi.nlm.nih.gov/42397736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,41436431,Targeting MED23 inhibits hepatocellular carcinoma development by suppressing compensatory proliferation and facilitating ROS-mediated cell death.,2025,10.1038/s41419-025-08348-8,https://pubmed.ncbi.nlm.nih.gov/41436431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,42548313,Vascular Patterning Shapes Intramembranous Ossification via the HIF1α-VEGF Axis.,2026,10.1177/00220345261463156,https://pubmed.ncbi.nlm.nih.gov/42548313/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,41633977,Splice isoform-perturbation coupled to single cell transcriptome profiling reveals functions of microexons in neurogenesis and autism-linked pathways.,2026,10.1038/s41467-025-67931-x,https://pubmed.ncbi.nlm.nih.gov/41633977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,41448431,Cantu syndrome-associated SUR2[H60Y] mutation confers selective gain of function on Kir6.1 ATP-sensitive potassium channels.,2026,10.1016/j.jbc.2025.111105,https://pubmed.ncbi.nlm.nih.gov/41448431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,42290677,"Cognitive Decline, Neurologic Involvement, and Neonatal Crisis in &lt;i&gt;ABCC9&lt;/i&gt;-Related Intellectual Disability and Myopathy Syndrome.",2026,10.1212/nxg.0000000000200385,https://pubmed.ncbi.nlm.nih.gov/42290677/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,42295105,Will the real KATP please stand up? Kir6.2/SUR2A takes the stand in the tiring case of skeletal muscle fatigue.,2026,10.1085/jgp.202614036,https://pubmed.ncbi.nlm.nih.gov/42295105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,41020224,Gain-of-function mutations in KATP channel subunits compromise colonic tight junction integrity and epithelial homeostasis in murine models of Cantú syndrome.,2025,10.3389/fmed.2025.1656718,https://pubmed.ncbi.nlm.nih.gov/41020224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,41055640,Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice.,2025,10.1085/jgp.202513781,https://pubmed.ncbi.nlm.nih.gov/41055640/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,40705824,Mediator complex subunit MED23 dampens antiviral innate immunity by restricting RIG-I expression.,2025,10.1371/journal.pbio.3003294,https://pubmed.ncbi.nlm.nih.gov/40705824/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,40263353,Structural basis of human Mediator recruitment by the phosphorylated transcription factor Elk-1.,2025,10.1038/s41467-025-59014-8,https://pubmed.ncbi.nlm.nih.gov/40263353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,40114018,Central Med23 deficiency leads to malformation of dentate gyrus and ADHD-like behaviors in mice.,2025,10.1038/s41386-025-02088-1,https://pubmed.ncbi.nlm.nih.gov/40114018/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,39402028,Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs.,2024,10.1038/s41421-024-00730-8,https://pubmed.ncbi.nlm.nih.gov/39402028/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,41465117,"Genetic, Clinical and Neuroradiological Spectrum of MED-Related Disorders: An Updated Review.",2025,10.3390/genes16121444,https://pubmed.ncbi.nlm.nih.gov/41465117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,39144687,MED23 pathogenic variant: genomic-phenotypic analysis.,2024,10.25122/jml-2024-0065,https://pubmed.ncbi.nlm.nih.gov/39144687/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,41092117,"The CYP71A, NIT, AMI, and IAMH gene families are dispensable for indole-3-acetaldoxime-mediated auxin biosynthesis in Arabidopsis.",2025,10.1093/plcell/koaf242,https://pubmed.ncbi.nlm.nih.gov/41092117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,40344646,CD103&lt;sup&gt;+&lt;/sup&gt; T Cells Eliminate Damaged Alveolar Epithelial Type II Cells Under Oxidative Stress to Prevent Lung Tumorigenesis.,2025,10.1002/advs.202503557,https://pubmed.ncbi.nlm.nih.gov/40344646/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,39819176,Control of neurovascular coupling by ATP-sensitive potassium channels.,2025,10.1177/0271678x251313906,https://pubmed.ncbi.nlm.nih.gov/39819176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,38217872,Novel loss-of-function variants expand ABCC9-related intellectual disability and myopathy syndrome.,2024,10.1093/brain/awae010,https://pubmed.ncbi.nlm.nih.gov/38217872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,41960079,Myocardial protection by adenosine triphosphate-sensitive potassium channel opener diazoxide involves sulfonylurea receptor 2 subunit.,2026,10.1016/j.xjon.2025.10.018,https://pubmed.ncbi.nlm.nih.gov/41960079/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,38195889,Med23 deficiency reprograms the tumor microenvironment to promote lung tumorigenesis.,2024,10.1038/s41416-023-02556-9,https://pubmed.ncbi.nlm.nih.gov/38195889/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,40630191,&lt;i&gt;Boikoetliso Ba Boko&lt;/i&gt; ('exercising the mind'): protocol for a mixed methods feasibility and acceptability study of a prototype mental health intervention for adolescents and young people with anxiety and depression.,2025,10.3389/frcha.2025.1569135,https://pubmed.ncbi.nlm.nih.gov/40630191/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,37999979,LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation.,2023,10.1016/j.celrep.2023.113479,https://pubmed.ncbi.nlm.nih.gov/37999979/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,42178735,"A cytochrome P450 gene, GmSUR2&lt;sup&gt;a&lt;/sup&gt;, confers submergence tolerance and improves yield in soybean by modulating auxin homeostasis.",2026,10.1111/jipb.70299,https://pubmed.ncbi.nlm.nih.gov/42178735/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,37965230,Pulmonary hypertension associated with diazoxide: the SUR1 paradox.,2023,10.1183/23120541.00350-2023,https://pubmed.ncbi.nlm.nih.gov/37965230/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,37154692,Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS.,2023,10.15252/emmm.202216883,https://pubmed.ncbi.nlm.nih.gov/37154692/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,40551265,Mediator complex: update of key insights into transcriptional regulation of ancestral framework and its role in cardiovascular diseases.,2025,10.1186/s40001-025-02720-2,https://pubmed.ncbi.nlm.nih.gov/40551265/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,35963541,Interrupting specific hydrogen bonds between ELF3 and MED23 as an alternative drug resistance-free strategy for HER2-overexpressing cancers.,2023,10.1016/j.jare.2022.08.003,https://pubmed.ncbi.nlm.nih.gov/35963541/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,36704469,Involvement of SUR2/Kir6.1 channel in the physiopathology of pulmonary arterial hypertension.,2022,10.3389/fcvm.2022.1066047,https://pubmed.ncbi.nlm.nih.gov/36704469/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,35440711,Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression.,2022,10.1038/s42003-022-03332-w,https://pubmed.ncbi.nlm.nih.gov/35440711/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,40340861,Targeting the HER2-ELF3-KRAS axis: a novel therapeutic strategy for KRASG13D colorectal cancer.,2025,10.1186/s12943-025-02343-5,https://pubmed.ncbi.nlm.nih.gov/40340861/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED23,ENSG00000112282,Unsafe,35672824,Integration of radiogenomic features for early prediction of pathological complete response in patients with triple-negative breast cancer and identification of potential therapeutic targets.,2022,10.1186/s12967-022-03452-1,https://pubmed.ncbi.nlm.nih.gov/35672824/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,42831021,MED26 facilitates Mediator-Pol II complex assembly and promotes nuclear stress body formation during heat stress.,2026,10.1016/j.isci.2026.117557,https://pubmed.ncbi.nlm.nih.gov/42831021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,40950882,Lipid metabolism-related genes regulate the immune microenvironment during ex vivo lung perfusion for lung transplants.,2025,10.21037/jtd-2025-358,https://pubmed.ncbi.nlm.nih.gov/40950882/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,38955181,An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II.,2024,10.1016/j.molcel.2024.06.006,https://pubmed.ncbi.nlm.nih.gov/38955181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,39121214,"3D chromatin architecture, BRD4, and Mediator have distinct roles in regulating genome-wide transcriptional bursting and gene network.",2024,10.1126/sciadv.adl4893,https://pubmed.ncbi.nlm.nih.gov/39121214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,36852638,MED26-containing Mediator may orchestrate multiple transcription processes through organization of nuclear bodies.,2023,10.1002/bies.202200178,https://pubmed.ncbi.nlm.nih.gov/36852638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,39321804,Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module.,2024,10.1016/j.molcel.2024.09.001,https://pubmed.ncbi.nlm.nih.gov/39321804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,40827928,Dynamic interactions of retroviral Gag condensates with nascent viral RNA at transcriptional burst sites: implications for genomic RNA packaging.,2025,10.1128/mbio.01695-25,https://pubmed.ncbi.nlm.nih.gov/40827928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,38898526,Comparative analysis of retroviral Gag-host cell interactions: focus on the nuclear interactome.,2024,10.1186/s12977-024-00645-y,https://pubmed.ncbi.nlm.nih.gov/38898526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,32102997,The role of Mediator and Little Elongation Complex in transcription termination.,2020,10.1038/s41467-020-14849-1,https://pubmed.ncbi.nlm.nih.gov/32102997/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,33836240,A simple protocol to purify human TFIID free of the MED26 subunit of mediator complex.,2021,10.1016/j.pep.2021.105887,https://pubmed.ncbi.nlm.nih.gov/33836240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,36747093,Signal-induced enhancer activation requires Ku70 to read topoisomerase1-DNA covalent complexes.,2023,10.1038/s41594-022-00883-8,https://pubmed.ncbi.nlm.nih.gov/36747093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,35069777,Identification of Therapeutic Targets and Prognostic Biomarkers among Genes from the Mediator Complex Family in the Hepatocellular Carcinoma Tumour-Immune Microenvironment.,2022,10.1155/2022/2021613,https://pubmed.ncbi.nlm.nih.gov/35069777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,28270516,Cbx3 maintains lineage specificity during neural differentiation.,2017,10.1101/gad.292169.116,https://pubmed.ncbi.nlm.nih.gov/28270516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,34515029,Comparison of transcriptional initiation by RNA polymerase II across eukaryotic species.,2021,10.7554/elife.67964,https://pubmed.ncbi.nlm.nih.gov/34515029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,25575120,MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex.,2015,10.1038/ncomms6941,https://pubmed.ncbi.nlm.nih.gov/25575120/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,24820420,The metazoan-specific mediator subunit 26 (Med26) is essential for viability and is found at both active genes and pericentric heterochromatin in Drosophila melanogaster.,2014,10.1128/mcb.01365-13,https://pubmed.ncbi.nlm.nih.gov/24820420/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,28600779,The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes.,2017,10.1007/s00439-017-1821-8,https://pubmed.ncbi.nlm.nih.gov/28600779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,21729782,Human mediator subunit MED26 functions as a docking site for transcription elongation factors.,2011,10.1016/j.cell.2011.06.005,https://pubmed.ncbi.nlm.nih.gov/21729782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,22215486,Identification of mediator complex 26 (Crsp7) gametologs on platypus X1 and Y5 sex chromosomes: a candidate testis-determining gene in monotremes?,2012,10.1007/s10577-011-9270-z,https://pubmed.ncbi.nlm.nih.gov/22215486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,27564129,TBP loading by AF4 through SL1 is the major rate-limiting step in MLL fusion-dependent transcription.,2016,10.1080/15384101.2016.1222337,https://pubmed.ncbi.nlm.nih.gov/27564129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,25383669,Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit.,2014,10.1038/nsmb.2914,https://pubmed.ncbi.nlm.nih.gov/25383669/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MED26,ENSG00000105085,Unsafe,25100719,Characterization of the influence of mediator complex in HIV-1 transcription.,2014,10.1074/jbc.m114.570341,https://pubmed.ncbi.nlm.nih.gov/25100719/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,40265567,In Silico Discovery of Potential Inhibitors Targeting the MEIG1-PACRG Complex for Male Contraceptive Development.,2025,10.1002/prot.26829,https://pubmed.ncbi.nlm.nih.gov/40265567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,40035530,Normal embryo development needs MEIG1-mediated sperm formation.,2025,10.1096/fj.202500109r,https://pubmed.ncbi.nlm.nih.gov/40035530/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,37083624,DNALI1 interacts with the MEIG1/PACRG complex within the manchette and is required for proper sperm flagellum assembly in mice.,2023,10.7554/elife.79620,https://pubmed.ncbi.nlm.nih.gov/37083624/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,40172998,"Correction to ""Normal embryo development needs MEIG1-mediated sperm formation"".",2025,10.1096/fj.202500897,https://pubmed.ncbi.nlm.nih.gov/40172998/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,36091389,Identification and functional analysis of Tex11 and Meig1 in spermatogenesis of Hyriopsis cumingii.,2022,10.3389/fphys.2022.961773,https://pubmed.ncbi.nlm.nih.gov/36091389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,34673028,A single amino acid mutation in the mouse MEIG1 protein disrupts a cargo transport system necessary for sperm formation.,2021,10.1016/j.jbc.2021.101312,https://pubmed.ncbi.nlm.nih.gov/34673028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,36709584,Specific expression of alternatively spliced genes in the turkey (Meleagris gallopavo) reproductive tract revealed their function in spermatogenesis and post-testicular sperm maturation.,2023,10.1016/j.psj.2023.102484,https://pubmed.ncbi.nlm.nih.gov/36709584/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,33529594,Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding.,2021,10.1016/j.str.2021.01.001,https://pubmed.ncbi.nlm.nih.gov/33529594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,35257720,"MEIG1 determines the manchette localization of IFT20 and IFT88, two intraflagellar transport components in male germ cells.",2022,10.1016/j.ydbio.2022.03.001,https://pubmed.ncbi.nlm.nih.gov/35257720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,35518352,A Novel Allotriploid Hybrid Derived From Female Goldfish × Male Bleeker's Yellow Tail.,2022,10.3389/fgene.2022.880591,https://pubmed.ncbi.nlm.nih.gov/35518352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,37138703,The regeneration-responsive element careg monitors activation of Müller glia after MNU-induced damage of photoreceptors in the zebrafish retina.,2023,10.3389/fnmol.2023.1160707,https://pubmed.ncbi.nlm.nih.gov/37138703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,25715396,A MEIG1/PACRG complex in the manchette is essential for building the sperm flagella.,2015,10.1242/dev.119834,https://pubmed.ncbi.nlm.nih.gov/25715396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,23258628,Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice.,2013,10.1111/j.2047-2927.2012.00001.x,https://pubmed.ncbi.nlm.nih.gov/23258628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,25248657,"Characterization of membrane occupation and recognition nexus repeat containing 3, meiosis expressed gene 1 binding partner, in mouse male germ cells.",2015,10.4103/1008-682x.138186,https://pubmed.ncbi.nlm.nih.gov/25248657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,26726850,Dissecting the structural basis of MEIG1 interaction with PACRG.,2016,10.1038/srep18278,https://pubmed.ncbi.nlm.nih.gov/26726850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,23444080,The mouse transcription factor-like 5 gene encodes a protein localized in the manchette and centriole of the elongating spermatid.,2013,10.1111/j.2047-2927.2013.00069.x,https://pubmed.ncbi.nlm.nih.gov/23444080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,19805151,MEIG1 is essential for spermiogenesis in mice.,2009,10.1073/pnas.0906414106,https://pubmed.ncbi.nlm.nih.gov/19805151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,20004656,Meig1 deficiency causes a severe defect in mouse spermatogenesis.,2010,10.1016/j.ydbio.2009.11.028,https://pubmed.ncbi.nlm.nih.gov/20004656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,21312389,Gene expression alterations by conditional knockout of androgen receptor in adult Sertoli cells of Utp14b jsd/jsd (jsd) mice.,2011,10.1095/biolreprod.110.090530,https://pubmed.ncbi.nlm.nih.gov/21312389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEIG1,ENSG00000197889,Unsafe,20650881,Gene expression alterations by conditional knockout of androgen receptor in adult sertoli cells of Utp14b(jsd/jsd) (jsd) mice.,2010,10.1095/biolreprod.110.085472,https://pubmed.ncbi.nlm.nih.gov/20650881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
METTL21A,ENSG00000144401,Unsafe,42881250,Methylation-driven SOX18 nuclear translocation by IGF2BP1-stabilized METTL21A promotes lymphatic metastasis in gastric cancer.,2026,10.1038/s41388-026-04013-2,https://pubmed.ncbi.nlm.nih.gov/42881250/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
METTL21A,ENSG00000144401,Unsafe,40640484,METTL21A promotes hepatocellular carcinoma progression via methylating and stabilizing BAG3.,2025,10.1038/s41698-025-01021-5,https://pubmed.ncbi.nlm.nih.gov/40640484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
METTL21A,ENSG00000144401,Unsafe,38980841,Exome sequencing identifies novel genetic variants associated with varicose veins.,2024,10.1371/journal.pgen.1011339,https://pubmed.ncbi.nlm.nih.gov/38980841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
METTL21A,ENSG00000144401,Unsafe,35216057,"METTL21A, a Non-Histone Methyltransferase, Is Dispensable for Spermatogenesis and Male Fertility in Mice.",2022,10.3390/ijms23041942,https://pubmed.ncbi.nlm.nih.gov/35216057/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
METTL21A,ENSG00000144401,Unsafe,38511055,Integrative bioinformatics analysis of miRNA and mRNA expression profiles and identification of associated miRNA-mRNA network in intracranial aneurysms.,2024,10.1016/j.ncrna.2024.01.004,https://pubmed.ncbi.nlm.nih.gov/38511055/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
METTL21A,ENSG00000144401,Unsafe,38130905,Comprehensive Analysis of METTLs (METTL1/13/18/21A/23/25/2A/2B/5/6/9) and Associated mRNA Risk Signature in Hepatocellular Carcinoma.,2023,10.1155/2023/6007431,https://pubmed.ncbi.nlm.nih.gov/38130905/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
METTL21A,ENSG00000144401,Unsafe,35194111,Weighted correlation network analysis revealed novel long non-coding RNAs for colorectal cancer.,2022,10.1038/s41598-022-06934-w,https://pubmed.ncbi.nlm.nih.gov/35194111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
METTL21A,ENSG00000144401,Unsafe,32219808,Artificial Intelligence Analysis of Gene Expression Data Predicted the Prognosis of Patients with Diffuse Large B-Cell Lymphoma.,2020,,https://pubmed.ncbi.nlm.nih.gov/32219808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
METTL21A,ENSG00000144401,Unsafe,21696638,"Identification of a novel SEREX antigen family, ECSA, in esophageal squamous cell carcinoma.",2011,10.1186/1477-5956-9-31,https://pubmed.ncbi.nlm.nih.gov/21696638/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
METTL21A,ENSG00000144401,Unsafe,26115316,Saccharomyces cerevisiae Eukaryotic Elongation Factor 1A (eEF1A) Is Methylated at Lys-390 by a METTL21-Like Methyltransferase.,2015,10.1371/journal.pone.0131426,https://pubmed.ncbi.nlm.nih.gov/26115316/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
METTL21A,ENSG00000144401,Unsafe,25144183,Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferase.,2014,10.1371/journal.pone.0105394,https://pubmed.ncbi.nlm.nih.gov/25144183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
METTL21A,ENSG00000144401,Unsafe,28912266,Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress.,2017,10.1074/jbc.m117.797084,https://pubmed.ncbi.nlm.nih.gov/28912266/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
METTL21A,ENSG00000144401,Unsafe,23921388,Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.,2013,10.1074/jbc.m113.483248,https://pubmed.ncbi.nlm.nih.gov/23921388/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,42645760,Comprehensive pan-cancer analysis of MEX3A in human tumors.,2026,10.1007/s12672-026-05459-2,https://pubmed.ncbi.nlm.nih.gov/42645760/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,42137155,Pan-cancer analysis reveals the prognostic and therapeutic relevance of MEX3A with a focus on chromophobe renal cell carcinoma.,2026,10.3389/fonc.2026.1802679,https://pubmed.ncbi.nlm.nih.gov/42137155/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,41881339,MEX3A Modulates PPARγ Pathway Activity and Colorectal Cancer Growth.,2026,10.1016/j.jcmgh.2026.101771,https://pubmed.ncbi.nlm.nih.gov/41881339/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,42333008,Mex-3 RNA-binding family member A limits macrophage ferroptosis-associated injury linked to the SLC7A11/GPX4 pathway in diabetic atherosclerosis.,2026,10.1002/ctm2.70725,https://pubmed.ncbi.nlm.nih.gov/42333008/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,42080737,Copy Number Amplification and c-Myc Transcriptional Activation-Mediated RNA-Binding Protein MEX3A Promotes EGFR-TKI Resistance in Non-Small-Cell Lung Cancer.,2026,10.1111/1759-7714.70284,https://pubmed.ncbi.nlm.nih.gov/42080737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,42716134,MEX3A mediates DHRS3 instability to relieve G0/G1 arrest and facilitate hepatocellular carcinoma tumorigenesis and progression.,2026,10.1016/j.bcp.2026.118462,https://pubmed.ncbi.nlm.nih.gov/42716134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,42479360,Mex3a Stabilizes INHBB mRNA to Activate Smad Signaling and Promote Hepatocellular Carcinoma Metastasis.,2026,10.1245/s10434-026-20227-w,https://pubmed.ncbi.nlm.nih.gov/42479360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,42090027,Single-cell transcriptomic profiling of colorectal cancer brain metastasis.,2026,10.1007/s12672-026-05159-x,https://pubmed.ncbi.nlm.nih.gov/42090027/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,40958871,"MEX3A is a diagnostic, independent prognostic biomarker and a promising therapeutic target in glioblastoma.",2025,10.3389/fonc.2025.1585592,https://pubmed.ncbi.nlm.nih.gov/40958871/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,41161249,MEX3A-mediated super-enhancer RNA m6A methylation promotes aggressiveness of breast cancer via regulating RBM15B/IGF2BP3/KMT2C signaling.,2026,10.1016/j.tranon.2025.102580,https://pubmed.ncbi.nlm.nih.gov/41161249/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,40641106,"Role of MEX3A in tumorigenesis: Mechanisms, tumor‑specific effects and therapeutic implications (Review).",2025,10.3892/ijmm.2025.5579,https://pubmed.ncbi.nlm.nih.gov/40641106/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,40554097,MEX3A activates the JAK-STAT pathway to suppress NK cell cytotoxicity and accelerate lung adenocarcinoma progression.,2025,10.1016/j.cellimm.2025.104994,https://pubmed.ncbi.nlm.nih.gov/40554097/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,41114094,MEX3A promotes hepatocellular carcinoma cell proliferation and migration &lt;i&gt;via&lt;/i&gt; the Wnt/β-catenin and EMT pathways.,2025,10.4251/wjgo.v17.i10.106410,https://pubmed.ncbi.nlm.nih.gov/41114094/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,41114108,MEX3A: A promising prognostic marker and therapeutic target in hepatocellular carcinoma.,2025,10.4251/wjgo.v17.i10.106692,https://pubmed.ncbi.nlm.nih.gov/41114108/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,41525024,"Matrine functions as a tumor inhibitor to influence proliferation, metastasis and glycolysis in colorectal cancer via depending on METTL14-mediated m6A methylation of MEX3A.",2026,10.1007/s11010-025-05478-7,https://pubmed.ncbi.nlm.nih.gov/41525024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,40235874,MEX3A promotes cell proliferation by regulating the RORA/β-catenin pathway in hepatocellular carcinoma.,2025,10.4251/wjgo.v17.i4.102084,https://pubmed.ncbi.nlm.nih.gov/40235874/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,40668674,Mex3a-dependent post-transcriptional silencing ensures olfactory receptor diversity and axon guidance specificity.,2025,10.1016/j.celrep.2025.115979,https://pubmed.ncbi.nlm.nih.gov/40668674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,40530133,Identification of the MEX3 family as potential biomarkers of hepatocellular carcinoma based on bioinformatics and experiments.,2025,10.21037/tcr-24-2095,https://pubmed.ncbi.nlm.nih.gov/40530133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,39564121,Mex3a promoter hypomethylation can be utilized to diagnose HBV-associated hepatocellular carcinoma: a randomized controlled trial.,2024,10.3389/fphar.2024.1325869,https://pubmed.ncbi.nlm.nih.gov/39564121/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,40374855,Comprehensive bioinformatics analysis of MEX3 family genes in hepatocellular carcinoma.,2025,10.1038/s41598-025-02057-0,https://pubmed.ncbi.nlm.nih.gov/40374855/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,40487932,Correlation between prognostic markers and clinical parameters in hepatocellular carcinoma: Pathophysiological aspects to therapeutic targets.,2025,10.4251/wjgo.v17.i5.106278,https://pubmed.ncbi.nlm.nih.gov/40487932/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,38737272,Construction of a TP53 mutation-associated ceRNA network as prognostic biomarkers in hepatocellular carcinoma.,2024,10.1016/j.heliyon.2024.e30066,https://pubmed.ncbi.nlm.nih.gov/38737272/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,38914858,"MEX3A promotes colorectal cancer migration, invasion and EMT via regulating the Wnt/β-catenin signaling pathway.",2024,10.1007/s00432-024-05845-9,https://pubmed.ncbi.nlm.nih.gov/38914858/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,37845346,Core clock gene BMAL1 and RNA-binding protein MEX3A collaboratively regulate Lgr5 expression in intestinal crypt cells.,2023,10.1038/s41598-023-44997-5,https://pubmed.ncbi.nlm.nih.gov/37845346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,37521868,Activation of insulin-like growth factor-1 receptor (IGF-1R) promotes growth of colorectal cancer through triggering the MEX3A-mediated degradation of RIG-I.,2023,10.1016/j.apsb.2023.04.001,https://pubmed.ncbi.nlm.nih.gov/37521868/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,41613120,Integrative bioinformatic and experimental analysis reveals prognostic and immunological roles of MEX3 family genes in glioma.,2025,10.3389/fimmu.2025.1654036,https://pubmed.ncbi.nlm.nih.gov/41613120/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,34189143,Comprehensive Analysis of Prognostic Value of MEX3A and Its Relationship with Immune Infiltrates in Ovarian Cancer.,2021,10.1155/2021/5574176,https://pubmed.ncbi.nlm.nih.gov/34189143/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,34976441,RNA-binding protein MEX3A controls G1/S transition via regulating the RB/E2F pathway in clear cell renal cell carcinoma.,2022,10.1016/j.omtn.2021.11.026,https://pubmed.ncbi.nlm.nih.gov/34976441/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,36507941,Investigation of the Potential Correlation Between RNA-Binding Proteins in the Evolutionarily Conserved MEX3 Family and Non-small-Cell Lung Cancer.,2023,10.1007/s12033-022-00638-2,https://pubmed.ncbi.nlm.nih.gov/36507941/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MEX3A,ENSG00000254726,Unsafe,17267406,"Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies.",2007,10.1093/nar/gkm016,https://pubmed.ncbi.nlm.nih.gov/17267406/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFAP3L,ENSG00000198948,Unsafe,42740358,Testis-predominant gene &lt;i&gt;Mfap3l&lt;/i&gt; is dispensable for spermatogenesis under physiological conditions.,2026,10.7555/jbr.40.20260258,https://pubmed.ncbi.nlm.nih.gov/42740358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFAP3L,ENSG00000198948,Unsafe,39489826,"MFAP3L predicts tumor microenvironment status, molecular subtypes and clinical benefit in patients with bladder cancer.",2024,10.1038/s41598-024-77971-w,https://pubmed.ncbi.nlm.nih.gov/39489826/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFAP3L,ENSG00000198948,Unsafe,41484610,Low frequency and rare coding variants affect susceptibility and progression of childhood acute lymphoblastic leukemia.,2026,10.1186/s12935-025-04128-8,https://pubmed.ncbi.nlm.nih.gov/41484610/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFAP3L,ENSG00000198948,Unsafe,40598621,Identification of biomarkers associated with proliferation and differentiation of mesenchymal stem cells in pulmonary adenocarcinoma and establishment of prognostic models.,2025,10.1186/s41065-025-00492-7,https://pubmed.ncbi.nlm.nih.gov/40598621/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFAP3L,ENSG00000198948,Unsafe,40118907,Genome wide interaction study of genetic variants associated with lung function decline.,2025,10.1038/s41598-025-93147-6,https://pubmed.ncbi.nlm.nih.gov/40118907/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFAP3L,ENSG00000198948,Unsafe,40227386,Identification of Recurrence-associated Gene Signatures and Machine Learning-based Prediction in IDH-Wildtype Histological Glioblastoma.,2025,10.1007/s12031-025-02345-4,https://pubmed.ncbi.nlm.nih.gov/40227386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFAP3L,ENSG00000198948,Unsafe,36001729,Identifying platelet-derived factors as amplifiers of B. burgdorferi-induced cytokine production.,2022,10.1093/cei/uxac073,https://pubmed.ncbi.nlm.nih.gov/36001729/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFAP3L,ENSG00000198948,Unsafe,34841435,"MicroRNA‑671‑5p inhibits cell proliferation, migration and invasion in non‑small cell lung cancer by targeting MFAP3L.",2022,10.3892/mmr.2021.12546,https://pubmed.ncbi.nlm.nih.gov/34841435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFAP3L,ENSG00000198948,Unsafe,38528525,The mouse retinal pigment epithelium mounts an innate immune defense response following retinal detachment.,2024,10.1186/s12974-024-03062-2,https://pubmed.ncbi.nlm.nih.gov/38528525/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFAP3L,ENSG00000198948,Unsafe,34483672,High-Throughput Screening of Mouse Gene Knockouts Identifies Established and Novel High Body Fat Phenotypes.,2021,10.2147/dmso.s322083,https://pubmed.ncbi.nlm.nih.gov/34483672/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFAP3L,ENSG00000198948,Unsafe,26965286,A novel gene expression signature for bone metastasis in breast carcinomas.,2016,10.1007/s10549-016-3741-z,https://pubmed.ncbi.nlm.nih.gov/26965286/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFAP3L,ENSG00000198948,Unsafe,25390645,Genome-wide and gene-based association studies of anxiety disorders in European and African American samples.,2014,10.1371/journal.pone.0112559,https://pubmed.ncbi.nlm.nih.gov/25390645/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFAP3L,ENSG00000198948,Unsafe,18570457,Evaluation of hepatic-metastasis risk of colorectal cancer upon the protein signature of PI3K/AKT pathway.,2008,10.1021/pr800238p,https://pubmed.ncbi.nlm.nih.gov/18570457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD2B,ENSG00000205639,Unsafe,42717192,Structure and mechanism of human sphingosine-1-phosphate transporter MFSD2B.,2026,10.1038/s41467-026-76690-2,https://pubmed.ncbi.nlm.nih.gov/42717192/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD2B,ENSG00000205639,Unsafe,41890969,Insufficient erythrocyte-derived S1P: A pathogenic driver and diagnostic biolipid for tumor progression.,2026,10.1016/j.isci.2026.115216,https://pubmed.ncbi.nlm.nih.gov/41890969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD2B,ENSG00000205639,Unsafe,39110173,Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca2+ channel.,2024,10.1007/s00395-024-01073-x,https://pubmed.ncbi.nlm.nih.gov/39110173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD2B,ENSG00000205639,Unsafe,39924931,Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures.,2025,10.1111/acel.14482,https://pubmed.ncbi.nlm.nih.gov/39924931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD2B,ENSG00000205639,Unsafe,37358674,Identifying Key Genes and Functionally Enriched Pathways in Osteoporotic Patients by Weighted Gene Co-Expression Network Analysis.,2024,10.1007/s10528-023-10425-6,https://pubmed.ncbi.nlm.nih.gov/37358674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD2B,ENSG00000205639,Unsafe,37390971,An erythrocyte-centric view on the MFSD2B sphingosine-1-phosphate transporter.,2023,10.1016/j.pharmthera.2023.108483,https://pubmed.ncbi.nlm.nih.gov/37390971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD2B,ENSG00000205639,Unsafe,33863882,Deletion of Mfsd2b impairs thrombotic functions of platelets.,2021,10.1038/s41467-021-22642-x,https://pubmed.ncbi.nlm.nih.gov/33863882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD2B,ENSG00000205639,Unsafe,37100836,Revealing concealed cardioprotection by platelet Mfsd2b-released S1P in human and murine myocardial infarction.,2023,10.1038/s41467-023-38069-5,https://pubmed.ncbi.nlm.nih.gov/37100836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD2B,ENSG00000205639,Unsafe,33334894,Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b.,2021,10.1074/jbc.ra120.012941,https://pubmed.ncbi.nlm.nih.gov/33334894/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD2B,ENSG00000205639,Unsafe,38097610,Sphingosine-1-phosphate suppresses GLUT activity through PP2A and counteracts hyperglycemia in diabetic red blood cells.,2023,10.1038/s41467-023-44109-x,https://pubmed.ncbi.nlm.nih.gov/38097610/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD2B,ENSG00000205639,Unsafe,34260944,SPNS2 enables T cell egress from lymph nodes during an immune response.,2021,10.1016/j.celrep.2021.109368,https://pubmed.ncbi.nlm.nih.gov/34260944/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD2B,ENSG00000205639,Unsafe,33785361,Direct uptake of sphingosine-1-phosphate independent of phospholipid phosphatases.,2021,10.1016/j.jbc.2021.100605,https://pubmed.ncbi.nlm.nih.gov/33785361/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD2B,ENSG00000205639,Unsafe,29563527,MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells.,2018,10.1038/s41598-018-23300-x,https://pubmed.ncbi.nlm.nih.gov/29563527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD2B,ENSG00000205639,Unsafe,35609189,Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors.,2022,10.1021/acs.jmedchem.1c02171,https://pubmed.ncbi.nlm.nih.gov/35609189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD2B,ENSG00000205639,Unsafe,35301265,A general framework for identifying oligogenic combinations of rare variants in complex disorders.,2022,10.1101/gr.276348.121,https://pubmed.ncbi.nlm.nih.gov/35301265/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD2B,ENSG00000205639,Unsafe,26019538,Whole genome methylation analyses of schizophrenia patients before and after treatment.,2014,10.1080/13102818.2014.933501,https://pubmed.ncbi.nlm.nih.gov/26019538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD2B,ENSG00000205639,Unsafe,18694395,Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis.,2008,10.1042/bj20080165,https://pubmed.ncbi.nlm.nih.gov/18694395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD2B,ENSG00000205639,Unsafe,27301951,Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer.,2016,10.1007/s10565-016-9343-z,https://pubmed.ncbi.nlm.nih.gov/27301951/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD6L,ENSG00000185156,Unsafe,39038326,Identification and Validation of Prognostic Risk Model for Female-Specific Lung Adenocarcinoma.,2024,,https://pubmed.ncbi.nlm.nih.gov/39038326/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD6L,ENSG00000185156,Unsafe,33134824,Epigenome-Wide Association Study Using Prediagnostic Bloods Identifies New Genomic Regions Associated With Pancreatic Cancer Risk.,2020,10.1093/jncics/pkaa041,https://pubmed.ncbi.nlm.nih.gov/33134824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MFSD6L,ENSG00000185156,Unsafe,26979619,Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential.,2016,10.1186/s12864-016-2545-1,https://pubmed.ncbi.nlm.nih.gov/26979619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4C,ENSG00000182050,Unsafe,42417419,Mendelian Randomization and Transcriptome Analysis Identify Ischemic Stroke Biomarkers With Putative Relevance to Cerebrospinal Fluid.,2026,10.1155/bmri/2880611,https://pubmed.ncbi.nlm.nih.gov/42417419/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4C,ENSG00000182050,Unsafe,41010054,Integrating Network Analysis and Machine Learning Identifies Key Autism Spectrum Disorder Genes Linked to Immune Dysregulation and Therapeutic Targets.,2025,10.3390/genes16091109,https://pubmed.ncbi.nlm.nih.gov/41010054/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4C,ENSG00000182050,Unsafe,41307878,A novel inositol phosphate metabolism signature predicts survival prognosis in low grade glioma.,2025,10.1007/s12672-025-04177-5,https://pubmed.ncbi.nlm.nih.gov/41307878/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4C,ENSG00000182050,Unsafe,41244580,"Evolutionary analyses of the animal glycosyltransferase family 54 reveals two β1,4-N-acetylglucosaminyltransferase families.",2025,10.1016/j.isci.2025.113788,https://pubmed.ncbi.nlm.nih.gov/41244580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4C,ENSG00000182050,Unsafe,40814892,Comprehensive Analysis of Glycosyltransferase-Related Genes Reveals their Prognostic and Therapeutic Implications in Stomach Adenocarcinoma.,2026,10.2174/0113892037388672250728071209,https://pubmed.ncbi.nlm.nih.gov/40814892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4C,ENSG00000182050,Unsafe,35456975,Recognition of a Novel Gene Signature for Human Glioblastoma.,2022,10.3390/ijms23084157,https://pubmed.ncbi.nlm.nih.gov/35456975/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4C,ENSG00000182050,Unsafe,37308935,Characterization of aberrant glycosylation associated with osteoarthritis based on integrated glycomics methods.,2023,10.1186/s13075-023-03084-w,https://pubmed.ncbi.nlm.nih.gov/37308935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4C,ENSG00000182050,Unsafe,37918802,Gene purging and the evolution of Neoave metabolism and longevity.,2023,10.1016/j.jbc.2023.105409,https://pubmed.ncbi.nlm.nih.gov/37918802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4C,ENSG00000182050,Unsafe,38942348,The Contribution of Mosaic Chromosomal Alterations to Schizophrenia.,2025,10.1016/j.biopsych.2024.06.015,https://pubmed.ncbi.nlm.nih.gov/38942348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4C,ENSG00000182050,Unsafe,39596650,"Inference of Genetic Diversity, Population Structure, and Selection Signatures in Xiangxi White Buffalo of China Through Whole-Genome Resequencing.",2024,10.3390/genes15111450,https://pubmed.ncbi.nlm.nih.gov/39596650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4C,ENSG00000182050,Unsafe,31673966,Genome-wide association studies for growth traits in buffaloes using the single step genomic BLUP.,2020,10.1007/s13353-019-00528-5,https://pubmed.ncbi.nlm.nih.gov/31673966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4C,ENSG00000182050,Unsafe,34351956,Genome-wide association study of trypanosome prevalence and morphometric traits in purebred and crossbred Baoulé cattle of Burkina Faso.,2021,10.1371/journal.pone.0255089,https://pubmed.ncbi.nlm.nih.gov/34351956/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4C,ENSG00000182050,Unsafe,22496589,"Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk.",2012,10.1073/pnas.1117405109,https://pubmed.ncbi.nlm.nih.gov/22496589/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4C,ENSG00000182050,Unsafe,21937449,CD133 protein N-glycosylation processing contributes to cell surface recognition of the primitive cell marker AC133 epitope.,2011,10.1074/jbc.m111.261545,https://pubmed.ncbi.nlm.nih.gov/21937449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4C,ENSG00000182050,Unsafe,31092297,Genome-wide association study identifies novel loci for type 2 diabetes-attributed end-stage kidney disease in African Americans.,2019,10.1186/s40246-019-0205-7,https://pubmed.ncbi.nlm.nih.gov/31092297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MGAT4C,ENSG00000182050,Unsafe,10570912,"Cloning and characterization of the human UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homologue (hGnT-IV-H) gene.",1999,10.1007/s100380050186,https://pubmed.ncbi.nlm.nih.gov/10570912/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,40739853,cTAGE5/MEA6 Regulates LBR Localization to Maintain Nuclear Envelope Integrity and Safeguard Against Aging.,2025,10.1111/acel.70185,https://pubmed.ncbi.nlm.nih.gov/40739853/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,38439956,Mea6/cTAGE5 cooperates with TRAPPC12 to regulate PTN secretion and white matter development.,2024,10.1016/j.isci.2024.109180,https://pubmed.ncbi.nlm.nih.gov/38439956/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,39842788,"Tango1L but not Tango1S, Tali and cTAGE5 is required for export of type II collagen in medaka fish.",2025,10.1247/csf.25001,https://pubmed.ncbi.nlm.nih.gov/39842788/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,40593547,cTAGE5 is essential for adipogenesis and adipose tissue development.,2025,10.1038/s41467-025-60698-1,https://pubmed.ncbi.nlm.nih.gov/40593547/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,41950098,Alternative microexon splicing code for a four-amino acid peptide of PTPRD governs behavioral development.,2026,10.1073/pnas.2515310123,https://pubmed.ncbi.nlm.nih.gov/41950098/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,39872732,Ablation of Mea6/cTAGE5 in oligodendrocytes significantly impairs white matter structure and lipid content.,2023,10.1093/lifemeta/load010,https://pubmed.ncbi.nlm.nih.gov/39872732/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,38658535,TANGO1 inhibitors reduce collagen secretion and limit tissue scarring.,2024,10.1038/s41467-024-47004-1,https://pubmed.ncbi.nlm.nih.gov/38658535/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,30224460,cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development.,2018,10.1073/pnas.1804083115,https://pubmed.ncbi.nlm.nih.gov/30224460/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,38650832,TANGO1 Dances to Export of Procollagen from the Endoplasmic Reticulum.,2023,10.35534/fibrosis.2023.10008,https://pubmed.ncbi.nlm.nih.gov/38650832/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,40658698,Phenotype to genotype: A new and rapid approach using whole-genome sequencing.,2025,10.1371/journal.pgen.1011702,https://pubmed.ncbi.nlm.nih.gov/40658698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,29133483,cTAGE5 deletion in pancreatic β cells impairs proinsulin trafficking and insulin biogenesis in mice.,2017,10.1083/jcb.201705027,https://pubmed.ncbi.nlm.nih.gov/29133483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,31244610,MEA6 Deficiency Impairs Cerebellar Development and Motor Performance by Tethering Protein Trafficking.,2019,10.3389/fncel.2019.00250,https://pubmed.ncbi.nlm.nih.gov/31244610/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,33718348,Deletion of Mea6 in Cerebellar Granule Cells Impairs Synaptic Development and Motor Performance.,2020,10.3389/fcell.2020.627146,https://pubmed.ncbi.nlm.nih.gov/33718348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,35812061,CircNRIP1 acts as a sponge of miR-1200 to suppress osteosarcoma progression via upregulation of MIA2.,2022,,https://pubmed.ncbi.nlm.nih.gov/35812061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,38760510,Exploring the Biological Overlapping Between Brain Calcifications and Tumorgenesis.,2024,10.1007/s12031-024-02230-6,https://pubmed.ncbi.nlm.nih.gov/38760510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,33439675,Complementary and divergent functions of zebrafish Tango1 and Ctage5 in tissue development and homeostasis.,2021,10.1091/mbc.e20-11-0745,https://pubmed.ncbi.nlm.nih.gov/33439675/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,34441956,Melanoma Inhibitory Activity and Melanoma Inhibitory Activity 2 as Novel Immunohistochemical Markers of Oral Epithelial Dysplasia.,2021,10.3390/jcm10163661,https://pubmed.ncbi.nlm.nih.gov/34441956/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,27311593,Mea6 controls VLDL transport through the coordinated regulation of COPII assembly.,2016,10.1038/cr.2016.75,https://pubmed.ncbi.nlm.nih.gov/27311593/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,37730669,A Novel pyroptosis-related signature for predicting prognosis and evaluating tumor immune microenvironment in ovarian cancer.,2023,10.1186/s13048-023-01275-2,https://pubmed.ncbi.nlm.nih.gov/37730669/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,38991587,Endoplasmic reticulum exit sites are segregated for secretion based on cargo size.,2024,10.1016/j.devcel.2024.06.009,https://pubmed.ncbi.nlm.nih.gov/38991587/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,35954418,Prognostic Gene Expression-Based Signature in Clear-Cell Renal Cell Carcinoma.,2022,10.3390/cancers14153754,https://pubmed.ncbi.nlm.nih.gov/35954418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,34211824,Identification of a Seven-lncRNA-mRNA Signature for Recurrence and Prognostic Prediction in Relapsed Acute Lymphoblastic Leukemia Based on WGCNA and LASSO Analyses.,2021,10.1155/2021/6692022,https://pubmed.ncbi.nlm.nih.gov/34211824/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,23511560,Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma.,2013,10.1038/bjc.2013.27,https://pubmed.ncbi.nlm.nih.gov/23511560/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,27413011,Distinct isoform-specific complexes of TANGO1 cooperatively facilitate collagen secretion from the endoplasmic reticulum.,2016,10.1091/mbc.e16-03-0196,https://pubmed.ncbi.nlm.nih.gov/27413011/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,21525241,cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites.,2011,10.1091/mbc.e11-02-0143,https://pubmed.ncbi.nlm.nih.gov/21525241/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,23054591,Analysis of the CTAGE5 P521A variation with the risk of familial idiopathic basal ganglia calcification in an Iranian population.,2013,10.1007/s12031-012-9898-y,https://pubmed.ncbi.nlm.nih.gov/23054591/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,33552133,Gene Expression Changes and Associated Pathways Involved in the Progression of Prostate Cancer Advanced Stages.,2020,10.3389/fgene.2020.613162,https://pubmed.ncbi.nlm.nih.gov/33552133/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,27138255,TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky pre-chylomicrons/VLDLs from the endoplasmic reticulum.,2016,10.1083/jcb.201603072,https://pubmed.ncbi.nlm.nih.gov/27138255/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,12839582,cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing.,2003,10.1046/j.1523-1747.2003.12318.x,https://pubmed.ncbi.nlm.nih.gov/12839582/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIA2,ENSG00000150527,Unsafe,12586826,Specific expression and regulation of the new melanoma inhibitory activity-related gene MIA2 in hepatocytes.,2003,10.1074/jbc.m212639200,https://pubmed.ncbi.nlm.nih.gov/12586826/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,42414270,Unraveling the dual roles of MICAL2 in skeletal muscle physiology and fusion negative rhabdomyosarcoma tumor progression.,2026,10.1038/s41419-026-09029-w,https://pubmed.ncbi.nlm.nih.gov/42414270/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,42601381,MICAL2 as a key effector of β-catenin signaling driving melanoma progression and therapeutic resistance.,2026,10.1038/s41418-026-01811-9,https://pubmed.ncbi.nlm.nih.gov/42601381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,41998659,SIRT6 cooperates with KDM5C to transcriptionally silence MICAL2 and inhibit tumorigenesis in pancreatic cancer.,2026,10.1186/s12964-026-02886-0,https://pubmed.ncbi.nlm.nih.gov/41998659/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,41832266,LINC-AC092535.5 regulates MICAL2 mRNA level to inhibit p53-mediated ferroptosis in nasopharyngeal carcinoma.,2026,10.1038/s41388-026-03714-y,https://pubmed.ncbi.nlm.nih.gov/41832266/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,41797580,Endosomal actin attenuation and fission are regulated by MICAL2.,2026,10.1242/jcs.264592,https://pubmed.ncbi.nlm.nih.gov/41797580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,42349829,Novel genetic insights into causal effects of depression on non-alcoholic fatty liver diseases partially mediated by gut microbiota.,2026,10.1016/j.pnpbp.2026.111806,https://pubmed.ncbi.nlm.nih.gov/42349829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,42838434,"Lipid droplet-associated proteins integrate lipid metabolism, cell cycle, and cytoskeletal remodeling in colon cancer.",2026,10.1016/j.jlr.2026.101165,https://pubmed.ncbi.nlm.nih.gov/42838434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,39745352,MICAL2 Promotes Pancreatic Cancer Growth and Metastasis.,2025,10.1158/0008-5472.can-24-0744,https://pubmed.ncbi.nlm.nih.gov/39745352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,42157878,Identification of Key Genes and Exploration of Therapeutic Targets for Chronic Tendon Injury Based on Bioinformatics and Machine Learning.,2026,10.2147/ijgm.s591312,https://pubmed.ncbi.nlm.nih.gov/42157878/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,39661267,"Prognostic biomarker MICAL2 and associates with proliferation, migration and immune infiltration in pancreatic adenocarcinoma.",2025,10.1007/s13353-024-00919-3,https://pubmed.ncbi.nlm.nih.gov/39661267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,39799334,Molecule interacting with CasL-2 enhances tumor progression and alters radiosensitivity in cervical cancer.,2025,10.1186/s12967-024-06065-y,https://pubmed.ncbi.nlm.nih.gov/39799334/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,40822859,LncRNA &lt;i&gt;MYO16-AS1&lt;/i&gt; and &lt;i&gt;MICAL2&lt;/i&gt; axis sustains proliferation and migration in ovarian cancer cells and unveils a therapeutic vulnerability in patient-derived tumor organoids.,2025,10.1016/j.ncrna.2025.07.005,https://pubmed.ncbi.nlm.nih.gov/40822859/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,41965873,Predicting intracranial hypertension as a secondary insult using the pathological peptidome of brain injured patients.,2026,10.1038/s41598-026-46313-3,https://pubmed.ncbi.nlm.nih.gov/41965873/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,40943497,Analysis of Microarray and Single-Cell RNA-Seq Finds Gene Co-Expression and Tumor Environment Associated with Extracellular Matrix in Epithelial-Mesenchymal Transition in Prostate Cancer.,2025,10.3390/ijms26178575,https://pubmed.ncbi.nlm.nih.gov/40943497/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,40240704,"The role of MICAL2 in cancer progression: mechanisms, challenges, and therapeutic potential.",2025,10.1007/s13577-025-01212-z,https://pubmed.ncbi.nlm.nih.gov/40240704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,41550487,"Identification of COL8A2, MICAL2, and TNFSF10 as potential biomarkers associated with both exercise response and osteoarthritis: a multi-omics integration study.",2026,10.1007/s13205-025-04685-9,https://pubmed.ncbi.nlm.nih.gov/41550487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,38326344,MICAL2 implies immunosuppressive features and acts as an independent and adverse prognostic biomarker in pancreatic cancer.,2024,10.1038/s41598-024-52729-6,https://pubmed.ncbi.nlm.nih.gov/38326344/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,38137053,Gas6-Axl Signaling Induces SRF/MRTF-A Gene Transcription via MICAL2.,2023,10.3390/genes14122231,https://pubmed.ncbi.nlm.nih.gov/38137053/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,41510326,"Anticancer effects of red grape, and resveratrol on AGS gastric cancer cell line and investigation of related gene expression.",2026,10.1007/s10616-025-00884-7,https://pubmed.ncbi.nlm.nih.gov/41510326/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,41219734,Whole-exome sequencing of FFPE samples reveals mutations associated with Luminal A breast cancer recurrence.,2025,10.1186/s12896-025-01053-6,https://pubmed.ncbi.nlm.nih.gov/41219734/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,34868922,MICAL2 Promotes Proliferation and Migration of Glioblastoma Cells Through TGF-β/p-Smad2/EMT-Like Signaling Pathway.,2021,10.3389/fonc.2021.735180,https://pubmed.ncbi.nlm.nih.gov/34868922/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,36271377,Exosome-like nanovesicles derived from Phellinus linteus inhibit Mical2 expression through cross-kingdom regulation and inhibit ultraviolet-induced skin aging.,2022,10.1186/s12951-022-01657-6,https://pubmed.ncbi.nlm.nih.gov/36271377/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,35754837,Immunophenotypic Landscape and Prognosis-Related mRNA Signature in Diffuse Large B Cell Lymphoma.,2022,10.3389/fgene.2022.872001,https://pubmed.ncbi.nlm.nih.gov/35754837/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,37310483,"Isolation of three MiDi19-4 genes from mango, the ectopic expression of which confers early flowering and enhances stress tolerance in transgenic Arabidopsis.",2023,10.1007/s00425-023-04172-6,https://pubmed.ncbi.nlm.nih.gov/37310483/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MICAL2,ENSG00000133816,Unsafe,26635870,Genome-Wide Screening of mRNA Expression in Leprosy Patients.,2015,10.3389/fgene.2015.00334,https://pubmed.ncbi.nlm.nih.gov/26635870/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MINDY4,ENSG00000106125,Unsafe,41869443,FAM188B promotes progression of hepatocellular carcinoma by regulating YAP/TAZ via interaction with USP10.,2026,10.7150/jca.125659,https://pubmed.ncbi.nlm.nih.gov/41869443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MINDY4,ENSG00000106125,Unsafe,38844182,"FAM188B promotes the growth, metastasis, and invasion of hepatocellular carcinoma by targeting the hnRNPA1/PKM2 axis.",2024,10.1016/j.bbamcr.2024.119773,https://pubmed.ncbi.nlm.nih.gov/38844182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MINDY4,ENSG00000106125,Unsafe,39765701,Identifying Significant SNPs of the Total Number of Piglets Born and Their Relationship with Leg Bumps in Pigs.,2024,10.3390/biology13121034,https://pubmed.ncbi.nlm.nih.gov/39765701/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MINDY4,ENSG00000106125,Unsafe,33142744,FAM188B Expression Is Critical for Cell Growth via FOXM1 Regulation in Lung Cancer.,2020,10.3390/biomedicines8110465,https://pubmed.ncbi.nlm.nih.gov/33142744/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MINDY4,ENSG00000106125,Unsafe,40900534,Polygenic risk of refractory celiac disease type II and its association with autoimmune diseases: a phenome-wide association study in the UK Biobank.,2025,10.1097/meg.0000000000003036,https://pubmed.ncbi.nlm.nih.gov/40900534/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MINDY4,ENSG00000106125,Unsafe,33440835,FAM188B Downregulation Sensitizes Lung Cancer Cells to Anoikis via EGFR Downregulation and Inhibits Tumor Metastasis In Vivo.,2021,10.3390/cancers13020247,https://pubmed.ncbi.nlm.nih.gov/33440835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MINDY4,ENSG00000106125,Unsafe,29795372,FAM188B enhances cell survival via interaction with USP7.,2018,10.1038/s41419-018-0650-6,https://pubmed.ncbi.nlm.nih.gov/29795372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MINDY4,ENSG00000106125,Unsafe,38859938,Genome-wide associations with longevity and reproductive traits in U.S. rangeland ewes.,2024,10.3389/fgene.2024.1398123,https://pubmed.ncbi.nlm.nih.gov/38859938/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MINDY4,ENSG00000106125,Unsafe,34246774,"Novel Methods of Risk Stratifying Patients for Metachronous, Pre-Malignant Colorectal Polyps: A Systematic Review.",2021,10.1016/j.critrevonc.2021.103421,https://pubmed.ncbi.nlm.nih.gov/34246774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MINDY4,ENSG00000106125,Unsafe,27058892,Read-through transcripts in normal human lung parenchyma are down-regulated in lung adenocarcinoma.,2016,10.18632/oncotarget.8556,https://pubmed.ncbi.nlm.nih.gov/27058892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MINDY4,ENSG00000106125,Unsafe,29787419,A locus at 7p14.3 predisposes to refractory celiac disease progression from celiac disease.,2018,10.1097/meg.0000000000001168,https://pubmed.ncbi.nlm.nih.gov/29787419/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MINDY4,ENSG00000106125,Unsafe,22396660,"A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1.",2012,10.1371/journal.pgen.1002541,https://pubmed.ncbi.nlm.nih.gov/22396660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,38612805,Proteomic Analyses Reveal the Role of Alpha-2-Macroglobulin in Canine Osteosarcoma Cell Migration.,2024,10.3390/ijms25073989,https://pubmed.ncbi.nlm.nih.gov/38612805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,39726856,A multi-trait approach identified 7 novel genes for back pain.,2025,10.1097/pr9.0000000000001218,https://pubmed.ncbi.nlm.nih.gov/39726856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,31609475,"Functional characterization of a candidate tumor suppressor gene, Mirror Image Polydactyly 1, in nasopharyngeal carcinoma.",2020,10.1002/ijc.32732,https://pubmed.ncbi.nlm.nih.gov/31609475/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,34346026,Novel role of long non-coding RNAs in autoimmune cutaneous disease.,2022,10.1007/s12079-021-00639-x,https://pubmed.ncbi.nlm.nih.gov/34346026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,35922788,A prognostic Risk Score model for oral squamous cell carcinoma constructed by 6 glycolysis-immune-related genes.,2022,10.1186/s12903-022-02358-0,https://pubmed.ncbi.nlm.nih.gov/35922788/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,36067927,A novel homozygous variant in the GLI1 underlies postaxial polydactyly in a large consanguineous family with intra familial variable phenotypes.,2022,10.1016/j.ejmg.2022.104599,https://pubmed.ncbi.nlm.nih.gov/36067927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,32042744,Do lncRNAs and circRNAs expression profiles influence discoid lupus erythematosus progression?-a comprehensive analysis.,2019,10.21037/atm.2019.12.10,https://pubmed.ncbi.nlm.nih.gov/32042744/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,32321829,Landscape analysis of adjacent gene rearrangements reveals BCL2L14-ETV6 gene fusions in more aggressive triple-negative breast cancer.,2020,10.1073/pnas.1921333117,https://pubmed.ncbi.nlm.nih.gov/32321829/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,34721536,A Novel Homozygous Missense Mutation in the Zinc Finger DNA Binding Domain of GLI1 Causes Recessive Post-Axial Polydactyly.,2021,10.3389/fgene.2021.746949,https://pubmed.ncbi.nlm.nih.gov/34721536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,30459804,Clinical Genetics of Polydactyly: An Updated Review.,2018,10.3389/fgene.2018.00447,https://pubmed.ncbi.nlm.nih.gov/30459804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,33191407,Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site.,2021,10.1038/s41416-020-01153-4,https://pubmed.ncbi.nlm.nih.gov/33191407/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,27560520,Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology.,2016,10.1371/journal.pgen.1006149,https://pubmed.ncbi.nlm.nih.gov/27560520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,26515020,Advances in the molecular genetics of non-syndromic polydactyly.,2015,10.1017/erm.2015.18,https://pubmed.ncbi.nlm.nih.gov/26515020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,28488682,Exome sequencing revealed a splice site variant in the IQCE gene underlying post-axial polydactyly type A restricted to lower limb.,2017,10.1038/ejhg.2017.83,https://pubmed.ncbi.nlm.nih.gov/28488682/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,19667180,"Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinoma.",2009,10.1073/pnas.0900198106,https://pubmed.ncbi.nlm.nih.gov/19667180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,23456299,Hypermethylation of EBF3 and IRX1 genes in synovial fibroblasts of patients with rheumatoid arthritis.,2013,10.1007/s10059-013-2302-0,https://pubmed.ncbi.nlm.nih.gov/23456299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,28040783,Polygenic Control of Carotid Atherosclerosis in a BALB/cJ × SM/J Intercross and a Combined Cross Involving Multiple Mouse Strains.,2017,10.1534/g3.116.037879,https://pubmed.ncbi.nlm.nih.gov/28040783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,21148747,Both gene amplification and allelic loss occur at 14q13.3 in lung cancer.,2011,10.1158/1078-0432.ccr-10-1892,https://pubmed.ncbi.nlm.nih.gov/21148747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MIPOL1,ENSG00000151338,Unsafe,11954550,A novel gene is disrupted at a 14q13 breakpoint of t(2;14) in a patient with mirror-image polydactyly of hands and feet.,2002,10.1007/s100380200015,https://pubmed.ncbi.nlm.nih.gov/11954550/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,41697477,MLANA is a potential prognostic biomarker and correlated with immune infiltration in skin cutaneous melanoma.,2026,10.1007/s10238-026-02078-7,https://pubmed.ncbi.nlm.nih.gov/41697477/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,41858279,Skin Colour in Salamanders Is Modulated by Both Epitranscriptomic Methylation and Gene Expression.,2026,10.1111/mec.70302,https://pubmed.ncbi.nlm.nih.gov/41858279/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,42405419,Sex-Linked Dilution Colour in the European Domestic Goose Indicated To Be a 1-Bp Deletion in the Melan-A Gene.,2026,10.1002/age.70161,https://pubmed.ncbi.nlm.nih.gov/42405419/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,42316430,Transcriptomic Profiling of Cutaneous Melanoma Metastases Treated With Microwave Ablation-Pilot Study.,2026,10.1111/cts.70638,https://pubmed.ncbi.nlm.nih.gov/42316430/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,41309810,Spatial gene expression profiling reveals the distinct microenvironment of tuberous sclerosis complex-associated angiomyolipoma.,2025,10.1038/s41598-025-26541-9,https://pubmed.ncbi.nlm.nih.gov/41309810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,42801029,The Rare Case of a Sertoli Cell Tumor of the Adrenal Gland in a Man With Pathological Dexamethasone Suppression Test: A Case Report.,2026,10.7759/cureus.115277,https://pubmed.ncbi.nlm.nih.gov/42801029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,41593295,T-cell receptor clonotypic diversity and specialization in digestive system cancers.,2026,10.1038/s41698-026-01294-4,https://pubmed.ncbi.nlm.nih.gov/41593295/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,39898814,Polymorphism in the &lt;i&gt;MLANA&lt;/i&gt; gene and its association with feather pigmentation in Chinese yellow quail (&lt;i&gt;Coturnix japonica&lt;/i&gt;).,2025,10.1080/00071668.2025.2451243,https://pubmed.ncbi.nlm.nih.gov/39898814/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,41373617,Potential Genetic Markers Associated with Coloration in Duck: A Review.,2025,10.3390/ijms262311460,https://pubmed.ncbi.nlm.nih.gov/41373617/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,42629955,Framework for Establishing a Specialized Biobank and Digital Information Platform for Skin-on-a-Chip Research in Plastic Surgery.,2026,10.1177/19475535261479035,https://pubmed.ncbi.nlm.nih.gov/42629955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,41594442,Transcriptional and Metabolic Networks Underlying Melanin Deposition in Silkie Chicken Muscle: A Multi-Omics Insights.,2026,10.3390/ani16020252,https://pubmed.ncbi.nlm.nih.gov/41594442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,42545806,The Biological Basis of the Merlin CP-GEP Assay: Integrin Signaling and Early Metastatic Competence in Cutaneous Melanoma.,2026,10.1111/ijd.70610,https://pubmed.ncbi.nlm.nih.gov/42545806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,41384713,Spitz melanocytoma with&lt;i&gt; AKAP9::BRAF &lt;/i&gt;fusion: clinicopathologic and molecular insights.,2025,10.4081/dr.2025.10633,https://pubmed.ncbi.nlm.nih.gov/41384713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,41855479,LncRNA &lt;i&gt;Dlx4os&lt;/i&gt; drives malignant transformation and phenotype switching in melanoma.,2026,10.1080/15592294.2026.2641924,https://pubmed.ncbi.nlm.nih.gov/41855479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,39477686,Deciphering melanophagy: role of the PTK2-ITCH-MLANA-OPTN cascade on melanophagy in melanocytes.,2025,10.1080/15548627.2024.2421695,https://pubmed.ncbi.nlm.nih.gov/39477686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,41058174,CD8 co-receptor modulates the specificity profile of the 1G4 TCR against NY-ESO-1.,2026,10.1016/j.ymthe.2025.10.006,https://pubmed.ncbi.nlm.nih.gov/41058174/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,40424883,RNA sequencing and genome-wide association analysis reveal key genes responsible for different feather colors in Youjiang goose.,2025,10.1016/j.psj.2025.105305,https://pubmed.ncbi.nlm.nih.gov/40424883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,40507250,Immunohistochemistry for Skin Cancers: New Insights into Diagnosis and Treatment of Melanoma.,2025,10.3390/cancers17111769,https://pubmed.ncbi.nlm.nih.gov/40507250/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,40745198,Full length transcriptomic profiling reveals insights into the white coat phenotype in Waardenburg syndrome mice harboring the Mitf R324del mutation.,2025,10.1038/s41598-025-13359-8,https://pubmed.ncbi.nlm.nih.gov/40745198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,38970414,Expression patterns of melanin-related genes are linked to crypsis and conspicuousness in a pumpkin toadlet.,2025,10.1111/mec.17458,https://pubmed.ncbi.nlm.nih.gov/38970414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,41088891,Umbilical cord blood-derived cytotoxic T lymphocytes target melanoma via HLA-A2-restricted tumour antigens.,2025,10.1002/ctm2.70444,https://pubmed.ncbi.nlm.nih.gov/41088891/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,41644086,"Hydroxypinacolone 9-cis retinoate mitigates UV-induced photoaging by modulating extracellular matrix, fibroblasts, inflammation, and melanogenesis.",2026,10.1016/j.jid.2026.01.020,https://pubmed.ncbi.nlm.nih.gov/41644086/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,39755122,Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation.,2025,10.1016/j.immuni.2024.12.004,https://pubmed.ncbi.nlm.nih.gov/39755122/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,39312285,Patient-derived xenografts and single-cell sequencing identifies three subtypes of tumor-reactive lymphocytes in uveal melanoma metastases.,2024,10.7554/elife.91705,https://pubmed.ncbi.nlm.nih.gov/39312285/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,40004203,An MGRN1-Based Biomarker Combination Accurately Predicts Melanoma Patient Survival.,2025,10.3390/ijms26041739,https://pubmed.ncbi.nlm.nih.gov/40004203/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,40740618,Histiocytic Sarcoma Arising in a Background of Nodular Lymphocyte Predominant Hodgkin Lymphoma.,2025,10.1155/crh/9949707,https://pubmed.ncbi.nlm.nih.gov/40740618/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,38949179,"NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs.",2024,10.1158/2326-6066.cir-24-0061,https://pubmed.ncbi.nlm.nih.gov/38949179/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,38577557,Primary malignant melanoma of the genitourinary tract: case series of a rare form of primary mucosal melanoma.,2024,10.2217/mmt-2023-0009,https://pubmed.ncbi.nlm.nih.gov/38577557/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,38204924,CanVaxKB: a web-based cancer vaccine knowledgebase.,2024,10.1093/narcan/zcad060,https://pubmed.ncbi.nlm.nih.gov/38204924/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,37555308,In vivo targeting of a tumor-antigen encoded DNA vaccine to dendritic cells in combination with tumor-selective chemotherapy eradicates established mouse melanoma.,2023,10.1039/d3bm00702b,https://pubmed.ncbi.nlm.nih.gov/37555308/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,41413281,Independent Dutch Validation Study of CP-GEP (Merlin Assay) for the Prediction of Nodal Metastasis and Long-Term Outcome in Patients with Primary Cutaneous Melanoma.,2026,10.1245/s10434-025-18928-9,https://pubmed.ncbi.nlm.nih.gov/41413281/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,39611400,BMP10 Knockdown Modulates Endothelial Cell Immunoreactivity by Inhibiting the HIF-1α Pathway in the Sepsis-Induced Myocardial Injury.,2024,10.1111/jcmm.70232,https://pubmed.ncbi.nlm.nih.gov/39611400/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,37231180,Rapid TCR:Epitope Ranker (RAPTER): a primary human T cell reactivity screening assay pairing epitope and TCR at single cell resolution.,2023,10.1038/s41598-023-35710-7,https://pubmed.ncbi.nlm.nih.gov/37231180/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLANA,ENSG00000120215,Unsafe,35083152,Spatial Profiling Identifies Prognostic Features of Response to Adjuvant Therapy in Triple Negative Breast Cancer (TNBC).,2021,10.3389/fonc.2021.798296,https://pubmed.ncbi.nlm.nih.gov/35083152/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,41194443,CRISPR/Cas9-mediated genome editing identifies six testis-expressed genes individually dispensable for overt male fecundity in mice.,2026,10.7555/jbr.39.20250247,https://pubmed.ncbi.nlm.nih.gov/41194443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,41378129,Identification and experimental validation of demethylation-related genes in diabetic nephropathy.,2025,10.3389/fgene.2025.1675592,https://pubmed.ncbi.nlm.nih.gov/41378129/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,39657728,Downregulation of MLF1 safeguards cardiomyocytes against senescence-associated chromatin opening.,2025,10.1093/nar/gkae1176,https://pubmed.ncbi.nlm.nih.gov/39657728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,42247117,"NPM1-rearranged AML: clinical features, molecular pathogenesis, and therapeutic perspectives.",2026,10.1007/s12185-026-04234-x,https://pubmed.ncbi.nlm.nih.gov/42247117/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,41165044,"R405W Desmin Knock-In Mice Highlight Alterations of Mitochondria, Protein Quality Control and Myofibrils in Myofibrillar Myopathy.",2025,10.1002/jcsm.70094,https://pubmed.ncbi.nlm.nih.gov/41165044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,37486965,Epigenetic deregulation of MLF1 drives intrahepatic cholangiocarcinoma progression through EGFR/AKT and Wnt/β-catenin signaling.,2023,10.1097/hc9.0000000000000204,https://pubmed.ncbi.nlm.nih.gov/37486965/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,36814822,"Myeloid leukemia factor 1: A ""double-edged sword"" in health and disease.",2023,10.3389/fonc.2023.1124978,https://pubmed.ncbi.nlm.nih.gov/36814822/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,40158048,Spatial transcriptomic profiling of the human fallopian tube epithelium reveals region-specific gene expression patterns.,2025,10.1038/s42003-025-07871-w,https://pubmed.ncbi.nlm.nih.gov/40158048/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,39443736,NPM1-fusion proteins promote myeloid leukemogenesis through XPO1-dependent HOX activation.,2025,10.1038/s41375-024-02438-w,https://pubmed.ncbi.nlm.nih.gov/39443736/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,41569359,Identification of cryptic KMT2A-PTD and other novel fusion genes by transcriptome sequencing alters molecular risk stratification in AML-NK.,2026,10.1007/s00109-026-02639-z,https://pubmed.ncbi.nlm.nih.gov/41569359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,39432513,Mlf mediates proteotoxic response via formation of cellular foci for protein folding and degradation in Giardia.,2024,10.1371/journal.ppat.1012617,https://pubmed.ncbi.nlm.nih.gov/39432513/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,41715300,Rheological and Physicochemical Properties of Hyaluronic Acid Fillers for Body Contouring: Clinical Implications and Anatomical Considerations.,2026,10.1111/jocd.70553,https://pubmed.ncbi.nlm.nih.gov/41715300/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,39326207,Chronic lung inflammation and CK14+ basal cell proliferation induce persistent alveolar-bronchiolization in SARS-CoV-2-infected hamsters.,2024,10.1016/j.ebiom.2024.105363,https://pubmed.ncbi.nlm.nih.gov/39326207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,38726041,Nonsurgical Gluteal Volume Correction with Hyaluronic Acid: A Retrospective Study to Assess Long-term Safety and Efficacy.,2024,10.1097/gox.0000000000005792,https://pubmed.ncbi.nlm.nih.gov/38726041/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,38141912,Uncommon Protein-Coding Variants Associated With Suicide Attempt in a Diverse Sample of U.S. Army Soldiers.,2024,10.1016/j.biopsych.2023.12.008,https://pubmed.ncbi.nlm.nih.gov/38141912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,38872756,Unveiling blood pressure-associated genes in aortic cells through integrative analysis of GWAS and RNA modification-associated variants.,2024,10.1002/cdt3.124,https://pubmed.ncbi.nlm.nih.gov/38872756/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,34285685,"Anticancer effects of Morinda lucida and Annona muricata on immunomodulations of Melatonin, tumor necrosis factor-alpha and p53 concentrations in lead acetate-induced toxicity in rats.",2021,,https://pubmed.ncbi.nlm.nih.gov/34285685/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,31949731,MLF1 protein is a potential therapy target for lung adenocarcinoma.,2018,,https://pubmed.ncbi.nlm.nih.gov/31949731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,31675375,NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes.,2019,10.1371/journal.pgen.1008463,https://pubmed.ncbi.nlm.nih.gov/31675375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,32703400,CRL4DCAF8 and USP11 oppositely regulate the stability of myeloid leukemia factors (MLFs).,2020,10.1016/j.bbrc.2020.05.186,https://pubmed.ncbi.nlm.nih.gov/32703400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,42746489,Residue-based multilayer-filters reused as amendment after capturing pig slurry gases.,2026,10.1016/j.eti.2026.105111,https://pubmed.ncbi.nlm.nih.gov/42746489/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,28137643,MLF1 is a proapoptotic antagonist of HOP complex-mediated survival.,2017,10.1016/j.bbamcr.2017.01.016,https://pubmed.ncbi.nlm.nih.gov/28137643/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,36733771,Comparative transcriptome analysis of rainbow trout gonadal cells (RTG-2) infected with U and J genogroup infectious hematopoietic necrosis virus.,2022,10.3389/fmicb.2022.1109606,https://pubmed.ncbi.nlm.nih.gov/36733771/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,27840155,Modulation of mutant Huntingtin aggregates and toxicity by human myeloid leukemia factors.,2017,10.1016/j.biocel.2016.11.008,https://pubmed.ncbi.nlm.nih.gov/27840155/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,35472287,Efficient CRISPR/Cas9-mediated gene disruption in the tetraploid protist &lt;i&gt;Giardia intestinalis&lt;/i&gt;.,2022,10.1098/rsob.210361,https://pubmed.ncbi.nlm.nih.gov/35472287/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,23724000,Investigation of tissue-specific expression and functions of MLF1-IP during development and in the immune system.,2013,10.1371/journal.pone.0063783,https://pubmed.ncbi.nlm.nih.gov/23724000/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,31648321,Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia.,2019,10.1182/bloodadvances.2019000404,https://pubmed.ncbi.nlm.nih.gov/31648321/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,22885977,Myeloid leukemia factor: a return ticket from human leukemia to fly hematopoiesis.,2012,10.4161/trns.21490,https://pubmed.ncbi.nlm.nih.gov/22885977/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,17854834,Non-pathogenic protein aggregates in skeletal muscle in MLF1 transgenic mice.,2008,10.1016/j.jns.2007.07.027,https://pubmed.ncbi.nlm.nih.gov/17854834/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,26205622,Distinctive genotypes in infants with T-cell acute lymphoblastic leukaemia.,2015,10.1111/bjh.13613,https://pubmed.ncbi.nlm.nih.gov/26205622/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MLF1,ENSG00000178053,Unsafe,15861129,Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3.,2005,10.1038/sj.emboj.7600656,https://pubmed.ncbi.nlm.nih.gov/15861129/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,42908026,Capsaicin enhances chemosensitivity and mitigates MMP11-driven aggressiveness in human bladder cancer.,2026,10.1186/s12935-026-04397-x,https://pubmed.ncbi.nlm.nih.gov/42908026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,42920190,SPP1⁺ macrophage-derived WNT5A contributes to MMP11⁺ myCAF-mediated matrix remodeling and immunotherapy resistance in lung adenocarcinoma.,2026,10.1186/s12967-026-09069-y,https://pubmed.ncbi.nlm.nih.gov/42920190/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,42083565,Tumor-Promoting Crosstalk of MMP11⁺ Fibroblasts and SPP1⁺ Macrophages Drive Poor Prognosis in Breast Cancer: Integrated Multi-Omics Analysis.,2026,10.2147/itt.s564498,https://pubmed.ncbi.nlm.nih.gov/42083565/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,41265186,MMP11 promotes immune escape in esophageal carcinoma cells via the PD-L1/c-Myc signaling pathway.,2026,10.1016/j.tranon.2025.102604,https://pubmed.ncbi.nlm.nih.gov/41265186/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,42757034,"Single-cell RNA sequencing in diabetic foot ulcers: pathogenesis, biomarkers, and translational potential.",2026,10.3389/fcdhc.2026.1833678,https://pubmed.ncbi.nlm.nih.gov/42757034/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,42729537,Single-cell transcriptomics deciphers cancer-associated fibroblast heterogeneity and immune regulatory mechanisms in the bladder cancer tumor microenvironment.,2026,10.3389/fcell.2026.1889050,https://pubmed.ncbi.nlm.nih.gov/42729537/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,41057770,MMP11 predicts colorectal cancer outcomes and its inhibitor RXP03 exerts anti-tumor effects via apoptosis activation.,2025,10.1186/s12876-025-04322-y,https://pubmed.ncbi.nlm.nih.gov/41057770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,40604111,Matrix metalloproteinases as diagnostic and prognostic biomarkers in skin cutaneous melanoma and squamous cell carcinoma.,2025,10.1038/s41598-025-06608-3,https://pubmed.ncbi.nlm.nih.gov/40604111/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,41670526,"Expression and Clinical Significance of FOXQ1, MMP11, and CST1 in Colorectal Cancer.",2026,10.7754/clin.lab.2025.250764,https://pubmed.ncbi.nlm.nih.gov/41670526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,40386736,"Diagnostic accuracy of serum biomarkers MMP11 and SPP1 in non-small cell lung cancer: an analysis of sensitivity, specificity, and area under the curve.",2025,10.21037/tlcr-2024-1068,https://pubmed.ncbi.nlm.nih.gov/40386736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,40843631,MMP11 as a Prognostic Indicator for Inverted Papilloma Histologic Grade and Recurrence.,2026,10.1002/lary.70072,https://pubmed.ncbi.nlm.nih.gov/40843631/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,40977645,Transcription factor 3 enhances hepatocellular carcinoma metastasis by upregulating matrix metalloproteinase-11.,2025,10.4251/wjgo.v17.i9.110527,https://pubmed.ncbi.nlm.nih.gov/40977645/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,40607407,Landscape analysis of matrix metalloproteinases reveals key prognostic markers for prostate cancer.,2025,10.3389/fimmu.2025.1582992,https://pubmed.ncbi.nlm.nih.gov/40607407/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,42112999,In vivo inhibition of TDO2 in fibroids results in widespread alteration in the tumor transcriptome.,2026,10.1042/cs20260395,https://pubmed.ncbi.nlm.nih.gov/42112999/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,41272701,"Bioinformatic analysis and validation of candidate genes in the eutopic endometrium reveal differential expressions in diffuse adenomyosis, endometrioma, and their co-existence.",2025,10.1186/s40001-025-03412-7,https://pubmed.ncbi.nlm.nih.gov/41272701/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,42902496,The Characteristics of Tumor Microenvironment by the Single Cell Profile in Endometrial Cancer of no Specific Molecular Profile (NSMP) Subtype.,2026,10.1002/advs.78332,https://pubmed.ncbi.nlm.nih.gov/42902496/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,40552583,Single-Cell RNA Sequencing Identifies MMP11&lt;sup&gt;+&lt;/sup&gt; Cancer-Associated Fibroblasts as Drivers of Angiogenesis and Bladder Cancer Progression.,2025,10.1002/advs.202502774,https://pubmed.ncbi.nlm.nih.gov/40552583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,41301977,Evolutionary Dynamics of Matrix Metalloproteases with Collagenolytic Activity in Teleosts.,2025,10.3390/ani15223270,https://pubmed.ncbi.nlm.nih.gov/41301977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,42878251,pH-responsive hydrogel delivery of &lt;i&gt;Lycium barbarum&lt;/i&gt; glycopeptide coordinates immune-matrix crosstalk to enhance wound healing.,2026,10.1080/10717544.2026.2726621,https://pubmed.ncbi.nlm.nih.gov/42878251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,42146903,TAPINTO: A Novel Algorithm for Tumor-Associated Antigen Prediction Based on Information about Target Overexpression.,2026,10.34133/csbj.0109,https://pubmed.ncbi.nlm.nih.gov/42146903/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,42173653,Targeting VEGF signaling and stromal remodeling enhances chemoimmunotherapy efficacy in esophageal cancer.,2026,10.1136/jitc-2025-014249,https://pubmed.ncbi.nlm.nih.gov/42173653/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,41737832,Cuproptosis-related gene signatures define immune subtypes and predict prognosis in gastric cancer.,2026,10.3389/fmolb.2026.1746613,https://pubmed.ncbi.nlm.nih.gov/41737832/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,38989433,MMP11 as a prognostic biomarker correlated with immune infiltrates in pancreatic adenocarcinoma.,2024,10.21037/jgo-24-425,https://pubmed.ncbi.nlm.nih.gov/38989433/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,41850247,Spatial tumor evolution panorama of ovarian cancer.,2026,10.1016/j.xcrm.2026.102666,https://pubmed.ncbi.nlm.nih.gov/41850247/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,41568495,Identification of a Cuproptosis-Related Molecular Signature for Predicting Biochemical Recurrence in Prostate Cancer.,2026,10.2174/0113862073412459251117113248,https://pubmed.ncbi.nlm.nih.gov/41568495/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,41859002,RAB24 maps comprehensive clinical landscapes and mediates tumor malignant progression under the epigenetic regulation of miR-30b-3p and MMP11 in clear cell renal cell carcinoma.,2026,10.1016/j.gendis.2025.101869,https://pubmed.ncbi.nlm.nih.gov/41859002/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,39239548,Matrix Metalloproteinase 11 Promotes Migration and Invasion of Colorectal Cancer by Elevating Slug Protein.,2024,10.7150/ijms.98007,https://pubmed.ncbi.nlm.nih.gov/39239548/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMP11,ENSG00000099953,Unsafe,42148109,"Distribution and molecular drivers of the 21-gene recurrence score in early breast cancer with low, intermediate, and high estrogen receptor expression.",2026,10.3389/fimmu.2026.1653477,https://pubmed.ncbi.nlm.nih.gov/42148109/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,41446536,MMS22L is a novel key actor of normal and pathological erythropoiesis.,2025,10.1002/hem3.70264,https://pubmed.ncbi.nlm.nih.gov/41446536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,42002539,Comprehensive Bioinformatic Analysis of TONSL Expression in Pan-Cancer.,2026,10.1002/cnr2.70551,https://pubmed.ncbi.nlm.nih.gov/42002539/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,42912988,A noncanonical meiotic cohesin complex associates with specific MCM complexes to promote cohesion establishment and homolog bias.,2026,10.1126/sciadv.aej1008,https://pubmed.ncbi.nlm.nih.gov/42912988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,41570124,Treatment Response and Outcomes of Prostate Cancer Patients Carrying the Germline MMS22L F722fs Mutation.,2026,10.1002/pros.70133,https://pubmed.ncbi.nlm.nih.gov/41570124/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,41300761,"Toward a Multi-Trait Genetic Panel Targeting Training, Rehabilitation, and Chronic Disease Prevention: A Narrative Review.",2025,10.3390/genes16111309,https://pubmed.ncbi.nlm.nih.gov/41300761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,36276962,Integrative pan-cancer landscape of MMS22L and its potential role in hepatocellular carcinoma.,2022,10.3389/fgene.2022.1025970,https://pubmed.ncbi.nlm.nih.gov/36276962/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,41751043,"Genome Imputation for Genome-Wide Association Study of Reproductive Traits in Chinese Duroc, Landrace, and Yorkshire Pigs: Strategy and Validation.",2026,10.3390/ani16040583,https://pubmed.ncbi.nlm.nih.gov/41751043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,40652108,Characterizing aging-related genetic and physiological determinants of spinal curvature.,2025,10.1038/s43856-025-01003-5,https://pubmed.ncbi.nlm.nih.gov/40652108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,39999035,A Tiered Approach to Exome Sequencing Analysis in Early-Onset Primary Ovarian Insufficiency.,2025,10.1210/clinem/dgaf124,https://pubmed.ncbi.nlm.nih.gov/39999035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,39075111,Epigenetic aging studies of pair bonding in prairie voles.,2024,10.1038/s41598-024-67641-2,https://pubmed.ncbi.nlm.nih.gov/39075111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,36912084,Symmetric control of sister chromatid cohesion establishment.,2023,10.1093/nar/gkad146,https://pubmed.ncbi.nlm.nih.gov/36912084/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,34124145,The SOX9-MMS22L Axis Promotes Oxaliplatin Resistance in Colorectal Cancer.,2021,10.3389/fmolb.2021.646542,https://pubmed.ncbi.nlm.nih.gov/34124145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,34660277,MMS22L Expression as a Predictive Biomarker for the Efficacy of Neoadjuvant Chemoradiotherapy in Oesophageal Squamous Cell Carcinoma.,2021,10.3389/fonc.2021.711642,https://pubmed.ncbi.nlm.nih.gov/34660277/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,36622344,MMS22L-TONSL functions in sister chromatid cohesion in a pathway parallel to DSCC1-RFC.,2023,10.26508/lsa.202201596,https://pubmed.ncbi.nlm.nih.gov/36622344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,40313647,"Caffeine Consumption, Psychological Distress, and Insomnia in a Cohort of Individuals with Depression.",2025,10.1159/000545393,https://pubmed.ncbi.nlm.nih.gov/40313647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,36650183,CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer.,2023,10.1038/s41467-023-35880-y,https://pubmed.ncbi.nlm.nih.gov/36650183/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,36244801,Sex-Specific Genetic and Transcriptomic Liability to Neuroticism.,2023,10.1016/j.biopsych.2022.07.019,https://pubmed.ncbi.nlm.nih.gov/36244801/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,37372415,Genes and Athletic Performance: The 2023 Update.,2023,10.3390/genes14061235,https://pubmed.ncbi.nlm.nih.gov/37372415/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,26965286,A novel gene expression signature for bone metastasis in breast carcinomas.,2016,10.1007/s10549-016-3741-z,https://pubmed.ncbi.nlm.nih.gov/26965286/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,22895565,"Identification of a novel oncogene, MMS22L, involved in lung and esophageal carcinogenesis.",2012,10.3892/ijo.2012.1589,https://pubmed.ncbi.nlm.nih.gov/22895565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,27338793,H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex.,2016,10.1038/nature18312,https://pubmed.ncbi.nlm.nih.gov/27338793/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,34946969,Genome-Wide Association Study Candidate Genes on Mammary System-Related Teat-Shape Conformation Traits in Chinese Holstein Cattle.,2021,10.3390/genes12122020,https://pubmed.ncbi.nlm.nih.gov/34946969/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MMS22L,ENSG00000146263,Unsafe,30931099,Fresh and ozonized black carbon promoted DNA damage and repair responses in A549 cells.,2019,10.1039/c8tx00281a,https://pubmed.ncbi.nlm.nih.gov/30931099/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,42431870,MND1 regulates PANoptosis and stemness of lung adenocarcinoma cells by stabilizing RCOR2 mRNA.,2026,10.1038/s41419-026-09012-5,https://pubmed.ncbi.nlm.nih.gov/42431870/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,42236675,MND1 reduces breast cancer chemosensitivity by promoting RAD51-mediated homologous recombination repair.,2026,10.1038/s41419-026-08912-w,https://pubmed.ncbi.nlm.nih.gov/42236675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,42854377,Meiotic recombination proteins in cancer.,2026,10.1016/j.dnarep.2026.103963,https://pubmed.ncbi.nlm.nih.gov/42854377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,42856638,MND1 protein mediates DNA damage repair and is a promising novel therapeutic target in hepatocellular carcinoma.,2026,10.1016/j.livres.2026.08.002,https://pubmed.ncbi.nlm.nih.gov/42856638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,41668200,O-GlcNAcylation regulates the DNA damage repair function of MND1 in breast cancer.,2026,10.1186/s13058-026-02233-8,https://pubmed.ncbi.nlm.nih.gov/41668200/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,42725434,The dynamics of RAD51 foci formation and elongation in living human cells.,2026,10.1093/nar/gkag863,https://pubmed.ncbi.nlm.nih.gov/42725434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,41746729,HOP2-MND1 chaperones a diffusing DMC1-ssDNA complex to survey dsDNA for homology recognition during meiotic recombination.,2026,10.1073/pnas.2529249123,https://pubmed.ncbi.nlm.nih.gov/41746729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,39051055,Integrative Pan-Cancer Analysis Reveals the Oncogenic Role of MND1 and Validation of MND1's Role in Breast Cancer.,2024,10.2147/jir.s458832,https://pubmed.ncbi.nlm.nih.gov/39051055/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,42222260,&lt;i&gt;Phytophthora&lt;/i&gt; root rot induces compositional and functional changes in avocado rhizosphere bacterial communities.,2026,10.1093/femsmc/xtag025,https://pubmed.ncbi.nlm.nih.gov/42222260/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,41291041,Differential expression of reproduction and sex-determining genes in the gonads of genotypic and temperature-induced males of gibel carp (Carassius gibelio).,2025,10.1038/s41598-025-27347-5,https://pubmed.ncbi.nlm.nih.gov/41291041/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,40353402,MND1 Promotes the Proliferation of Prostate Cancer Cell &lt;i&gt;Via&lt;/i&gt; the CCNB1/p53 Signaling Pathway.,2025,10.2174/0115680096391591250506064859,https://pubmed.ncbi.nlm.nih.gov/40353402/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,37817120,FOXA1/MND1/TKT axis regulates gastric cancer progression and oxaliplatin sensitivity via PI3K/AKT signaling pathway.,2023,10.1186/s12935-023-03077-4,https://pubmed.ncbi.nlm.nih.gov/37817120/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,39191147,Integrated pan-cancer analysis and experimental verification of the roles of meiotic nuclear divisions 1 in breast cancer.,2024,10.1016/j.bbrc.2024.150600,https://pubmed.ncbi.nlm.nih.gov/39191147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,39463417,Hop2-Mnd1 functions as a DNA sequence fidelity switch in Dmc1-mediated DNA recombination.,2024,10.1038/s41467-024-53641-3,https://pubmed.ncbi.nlm.nih.gov/39463417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,42264440,Avena sativa L. boosts Lolium perenne L. growth through root exudate reprogramming under extreme high temperature.,2026,10.1016/j.plantsci.2026.113264,https://pubmed.ncbi.nlm.nih.gov/42264440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,37195379,MND1 enables homologous recombination in somatic cells primarily outside the context of replication.,2023,10.1002/1878-0261.13448,https://pubmed.ncbi.nlm.nih.gov/37195379/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,36098680,MND1 functions as a potential prognostic biomarker associated with cell cycle and immune infiltration in kidney renal clear cell carcinoma.,2022,10.18632/aging.204280,https://pubmed.ncbi.nlm.nih.gov/36098680/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,39779898,Characteristics of gut microbiota profiles in Asian elephants (Elephas maximus) with gastrointestinal disorders.,2025,10.1038/s41598-025-85495-0,https://pubmed.ncbi.nlm.nih.gov/39779898/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,40416872,Single-cell and spatial transcriptomics reveal correlation between RNA methylation-related miRNA risk model and immune infiltration in hepatocellular carcinoma.,2025,10.3389/fonc.2025.1553239,https://pubmed.ncbi.nlm.nih.gov/40416872/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,36352167,Meiotic nuclear divisions 1 promotes proliferation and metastasis in hepatocellular carcinoma and is a potential diagnostic and therapeutic target gene.,2022,10.1007/s12032-022-01875-w,https://pubmed.ncbi.nlm.nih.gov/36352167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,41475496,Polyethylene microplastics enhanced the toxicity of diisobutyl phthalate in saline soil microorganisms.,2026,10.1016/j.envpol.2025.127613,https://pubmed.ncbi.nlm.nih.gov/41475496/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,41791192,Potential of micro-molar H₂O₂ to stimulate soil As immobilization and carbon increase by wild low-As Pteris vittata L. litter.,2026,10.1016/j.jhazmat.2026.141667,https://pubmed.ncbi.nlm.nih.gov/41791192/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,41597572,Plant-Mediated Soil Sickness: Steering the Rhizosphere into a Pathogenic Niche.,2025,10.3390/microorganisms14010052,https://pubmed.ncbi.nlm.nih.gov/41597572/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,36366282,Genomic Transcriptome Benefits and Potential Harms of COVID-19 Vaccines Indicated from Optimized Genomic Biomarkers.,2022,10.3390/vaccines10111774,https://pubmed.ncbi.nlm.nih.gov/36366282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,36153483,The immune subtypes and landscape of sarcomas.,2022,10.1186/s12865-022-00522-3,https://pubmed.ncbi.nlm.nih.gov/36153483/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,41424711,Exosome and BCR-ABL mediated molecular alterations in endothelial cells in chronic myeloid leukemia: identification of seven genes and their regulatory network.,2025,10.7717/peerj.20371,https://pubmed.ncbi.nlm.nih.gov/41424711/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,41346825,Mechanisms of root exudates and soil microbial responses to nitrogen reduction and companion cropping for tomato yield increase and quality improvement.,2025,10.3389/fpls.2025.1642078,https://pubmed.ncbi.nlm.nih.gov/41346825/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,35601002,Using Weighted Gene Co-Expression Network Analysis to Identify Increased MND1 Expression as a Predictor of Poor Breast Cancer Survival.,2022,10.2147/ijgm.s354826,https://pubmed.ncbi.nlm.nih.gov/35601002/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,38219621,Sasa argenteostriata - A potential plant for phytostabilization remediation of lead-zinc tailing-contaminated soil.,2024,10.1016/j.ecoenv.2024.115969,https://pubmed.ncbi.nlm.nih.gov/38219621/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,36033890,Insight into functional microorganisms in wet-dry conversion to alleviate the toxicity of chromium fractions in red soil.,2022,10.3389/fmicb.2022.977171,https://pubmed.ncbi.nlm.nih.gov/36033890/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,33941804,Genetic network and gene set enrichment analyses identify MND1 as potential diagnostic and therapeutic target gene for lung adenocarcinoma.,2021,10.1038/s41598-021-88948-4,https://pubmed.ncbi.nlm.nih.gov/33941804/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,41247319,Rotation-driven changes in physicochemical properties modulate soil microbial diversity and community complexity in tobacco-woad soils.,2026,10.1128/spectrum.03016-24,https://pubmed.ncbi.nlm.nih.gov/41247319/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,40190892,Comparative Age Estimation Using 2D and 3D Imaging of Maxillary and Mandibular Molars: A Prospective Study.,2025,10.7759/cureus.80141,https://pubmed.ncbi.nlm.nih.gov/40190892/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,36272620,Risk assessment and microbial community structure in agricultural soils contaminated by vanadium from stone coal mining.,2023,10.1016/j.chemosphere.2022.136916,https://pubmed.ncbi.nlm.nih.gov/36272620/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MND1,ENSG00000121211,Unsafe,39588107,Deciphering differences in microbial community characteristics and main factors between healthy and root rot-infected &lt;i&gt;Carya cathayensis&lt;/i&gt; rhizosphere soils.,2024,10.3389/fmicb.2024.1448675,https://pubmed.ncbi.nlm.nih.gov/39588107/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,40520229,Identification of biomarkers for the diagnosis of chronic kidney disease (CKD) with dilated cardiomyopathy (DCM) by bioinformatics analysis and machine learning.,2025,10.3389/fgene.2025.1562891,https://pubmed.ncbi.nlm.nih.gov/40520229/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,42615880,Key regulatory genes and pathways in spermatogenesis identified by transcriptome profiling of the hypothalamic-pituitary-gonadal axis during sexual maturation in Wenchang roosters.,2026,10.1080/00071668.2026.2702458,https://pubmed.ncbi.nlm.nih.gov/42615880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,41115892,Identifying potential genetic biomarkers for sperm dysfunction through whole-genome sequencing.,2025,10.1038/s41598-025-23897-w,https://pubmed.ncbi.nlm.nih.gov/41115892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,40297163,Identification of signature genes and subtypes for heart failure diagnosis based on machine learning.,2025,10.3389/fcvm.2025.1492192,https://pubmed.ncbi.nlm.nih.gov/40297163/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,40633123,SGAM1 orchestrates salt tolerance by balancing mitochondrial translation and ROS homeostasis in Arabidopsis.,2025,10.1111/tpj.70322,https://pubmed.ncbi.nlm.nih.gov/40633123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,41342380,The embryo-derived protein PDI is highly conserved among placental mammals and alters the endometrial transcriptome and secretome in vitro across species with differing implantation strategies†.,2026,10.1093/biolre/ioaf263,https://pubmed.ncbi.nlm.nih.gov/41342380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,40424315,Evolutionary unique &lt;i&gt;N&lt;/i&gt;-glycan-dependent protein quality control system plays pivotal roles in cellular fitness and extracellular vesicle transport in &lt;i&gt;Cryptococcus neoformans&lt;/i&gt;.,2025,10.7554/elife.103729,https://pubmed.ncbi.nlm.nih.gov/40424315/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,38920647,Biallelic Variants in MNS1 Are Associated with Laterality Defects and Respiratory Involvement.,2024,10.3390/cells13121017,https://pubmed.ncbi.nlm.nih.gov/38920647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,37198331,BBOF1 is required for sperm motility and male fertility by stabilizing the flagellar axoneme in mice.,2023,10.1007/s00018-023-04800-0,https://pubmed.ncbi.nlm.nih.gov/37198331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,41898827,Genetic Diversity and Selection Signal Analysis of Xinjiang Black Pig Based on Whole Genome Resequencing.,2026,10.3390/genes17030293,https://pubmed.ncbi.nlm.nih.gov/41898827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,41740938,Multistep engineering of the secretory pathway for enhanced leghemoglobin expression in Kluyveromyces marxianus.,2026,10.1016/j.biortech.2026.134275,https://pubmed.ncbi.nlm.nih.gov/41740938/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,36863704,"Identification MNS1, FRZB, OGN, LUM, SERP1NA3 and FCN3 as the potential immune-related key genes involved in ischaemic cardiomyopathy by random forest and nomogram.",2023,10.18632/aging.204547,https://pubmed.ncbi.nlm.nih.gov/36863704/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,37275875,Heart failure-related genes associated with oxidative stress and the immune landscape in lung cancer.,2023,10.3389/fimmu.2023.1167446,https://pubmed.ncbi.nlm.nih.gov/37275875/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,35572891,"Integrated gene expression profiling analysis reveals SERPINA3, FCN3, FREM1, MNS1 as candidate biomarkers in heart failure and their correlation with immune infiltration.",2022,10.21037/jtd-22-22,https://pubmed.ncbi.nlm.nih.gov/35572891/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,33037173,A novel homozygous frameshift mutation in MNS1 associated with severe oligoasthenoteratozoospermia in humans.,2021,10.4103/aja.aja_56_20,https://pubmed.ncbi.nlm.nih.gov/33037173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,35602943,MNSs-mediated N-glycan processing is essential for auxin homeostasis in Arabidopsis roots during alkaline response.,2022,10.1016/j.isci.2022.104298,https://pubmed.ncbi.nlm.nih.gov/35602943/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,34755699,Sperm flagellar 2 (SPEF2) is essential for sperm flagellar assembly in humans.,2022,10.4103/aja202154,https://pubmed.ncbi.nlm.nih.gov/34755699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,30148830,Homozygous loss-of-function mutations in MNS1 cause laterality defects and likely male infertility.,2018,10.1371/journal.pgen.1007602,https://pubmed.ncbi.nlm.nih.gov/30148830/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,38641568,Identification of the principal neuropeptide MIP and its action pathway in larval settlement of the echiuran worm Urechis unicinctus.,2024,10.1186/s12864-024-10228-y,https://pubmed.ncbi.nlm.nih.gov/38641568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,35518352,A Novel Allotriploid Hybrid Derived From Female Goldfish × Male Bleeker's Yellow Tail.,2022,10.3389/fgene.2022.880591,https://pubmed.ncbi.nlm.nih.gov/35518352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,35726312,Integrated Bioinformatics Identifies FREM1 as a Diagnostic Gene Signature for Heart Failure.,2022,10.1155/2022/1425032,https://pubmed.ncbi.nlm.nih.gov/35726312/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,31361777,Antitumor activity of novel pyrazole-based small molecular inhibitors of the STAT3 pathway in patient derived high grade glioma cells.,2019,10.1371/journal.pone.0220569,https://pubmed.ncbi.nlm.nih.gov/31361777/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,35428952,Nestin and osteocrin mRNA increases in human semitendinosus myotendinous junction 7 days after a single bout of eccentric exercise.,2022,10.1007/s00418-022-02101-4,https://pubmed.ncbi.nlm.nih.gov/35428952/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,36051697,COVID-19 in pediatrics: Genetic susceptibility.,2022,10.3389/fgene.2022.928466,https://pubmed.ncbi.nlm.nih.gov/36051697/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,34631345,A proteomic analysis of Pseudevernia furfuracea after exposure to Cr+6 by MALDI-TOF mass spectrometry.,2021,10.1007/s13205-021-02986-3,https://pubmed.ncbi.nlm.nih.gov/34631345/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,29443940,Proteomic Differences in Feline Fibrosarcomas Grown Using Doxorubicin-Sensitive and -Resistant Cell Lines in the Chick Embryo Model.,2018,10.3390/ijms19020576,https://pubmed.ncbi.nlm.nih.gov/29443940/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,20511219,"Identification of an Htm1 (EDEM)-dependent, Mns1-independent Endoplasmic Reticulum-associated Degradation (ERAD) pathway in Saccharomyces cerevisiae: application of a novel assay for glycoprotein ERAD.",2010,10.1074/jbc.m109.095919,https://pubmed.ncbi.nlm.nih.gov/20511219/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,29426285,Transcriptome profiles in peripheral white blood cells at the time of artificial insemination discriminate beef heifers with different fertility potential.,2018,10.1186/s12864-018-4505-4,https://pubmed.ncbi.nlm.nih.gov/29426285/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,20560530,"Robust, high-throughput solution for blood group genotyping.",2010,10.1021/ac101008d,https://pubmed.ncbi.nlm.nih.gov/20560530/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MNS1,ENSG00000138587,Unsafe,36191189,SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.,2022,10.1073/pnas.2207605119,https://pubmed.ncbi.nlm.nih.gov/36191189/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,42311671,Critical changes in whole-brain gene networks in response to small-cell lung cancer as revealed by single-nucleus RNA sequencing.,2026,10.3389/fimmu.2026.1860628,https://pubmed.ncbi.nlm.nih.gov/42311671/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,42508567,"ADR, an optimized combination of ASIV, DLA, and R1, ameliorates blood-brain barrier disruption following rtPA thrombolysis at 4.5 h after stroke onset in mice via multitarget regulation.",2026,10.1016/j.jare.2026.07.058,https://pubmed.ncbi.nlm.nih.gov/42508567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,42317296,"Social isolation during adolescence alters novel object recognition memory, brain and gut gene expression, and microbiota composition in a sex-specific manner.",2026,10.1016/j.bbih.2026.101284,https://pubmed.ncbi.nlm.nih.gov/42317296/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,42283031,Single-cell transcriptomic profiling uncovers key molecular signatures in glioma pathogenesis.,2026,10.3389/fgene.2026.1818742,https://pubmed.ncbi.nlm.nih.gov/42283031/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,41789634,To Compare Different Blood Pressure Measurement Techniques in Patients with Chronic Kidney Disease.,2026,10.4103/aam.aam_261_25,https://pubmed.ncbi.nlm.nih.gov/41789634/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,40751749,Disruption of hnRNP A2-mediated RNA dynamics by amyloid-β drives MBP increase in Alzheimer's disease.,2025,10.1007/s00018-025-05823-5,https://pubmed.ncbi.nlm.nih.gov/40751749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,40465013,Multifactorial etiology of progressive supranuclear palsy (PSP): the genetic component.,2025,10.1007/s00401-025-02898-z,https://pubmed.ncbi.nlm.nih.gov/40465013/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,41808190,Enhanced myelination potential of human mature oligodendrocytes by TNF and IFNG combination.,2026,10.1186/s12974-026-03753-y,https://pubmed.ncbi.nlm.nih.gov/41808190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,40562752,Development and flight-testing of modular autonomous cultivation systems for biological plastics upcycling aboard the ISS.,2025,10.1038/s41526-025-00463-2,https://pubmed.ncbi.nlm.nih.gov/40562752/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,40890629,"Long-read sequencing identifies ATXN3 repeat expansions, and transcriptomics reveals disease progression biomarkers and druggable targets for spinocerebellar ataxia type 3.",2025,10.1186/s12883-025-04378-z,https://pubmed.ncbi.nlm.nih.gov/40890629/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,40366760,Impact of gene-gene interactions in Progressive Supranuclear Palsy: new genetic perspectives in the Asian-Indian population.,2025,10.1080/01677063.2025.2500953,https://pubmed.ncbi.nlm.nih.gov/40366760/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,42088849,Risk genes in progressive supranuclear palsy (PSP) affect integrity and function of microtubules.,2026,10.3389/fragi.2026.1769377,https://pubmed.ncbi.nlm.nih.gov/42088849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,40090391,Interrogating mediators of single-cell transcriptional changes in the acute damaged cerebral cortex: Insights into endothelial-astrocyte interactions.,2025,10.1016/j.mcn.2025.104003,https://pubmed.ncbi.nlm.nih.gov/40090391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,40743858,Characterizing oligodendrocyte-lineage cells and myelination in the basolateral amygdala: Insights from a novel methodology in postmortem human brain.,2025,10.1016/j.psychres.2025.116653,https://pubmed.ncbi.nlm.nih.gov/40743858/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,39251599,"Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes.",2024,10.1038/s41467-024-52025-x,https://pubmed.ncbi.nlm.nih.gov/39251599/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,40826098,Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes.,2025,10.1186/s13073-025-01519-4,https://pubmed.ncbi.nlm.nih.gov/40826098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,38889728,"Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia.",2024,10.1016/j.ajhg.2024.05.017,https://pubmed.ncbi.nlm.nih.gov/38889728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,40801579,Oligodendrocyte-Specific STAT5B Overexpression Ameliorates Myelin Impairment in Experimental Models of Parkinson's Disease.,2025,10.3390/cells14151145,https://pubmed.ncbi.nlm.nih.gov/40801579/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,39994758,Neurogenesis and glial impairments in congenital hydrocephalus: insights from a BioGlue-induced fetal lamb model.,2025,10.1186/s12987-025-00630-3,https://pubmed.ncbi.nlm.nih.gov/39994758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,33368549,MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis.,2021,10.1111/nan.12688,https://pubmed.ncbi.nlm.nih.gov/33368549/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,41136156,Resident or transient? Whole-genome approach to tracking colistin-resistant Escherichia coli in the broiler chicken processing chain.,2026,10.1016/j.fm.2025.104939,https://pubmed.ncbi.nlm.nih.gov/41136156/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,38843296,Heightened Epstein-Barr virus immunity and potential cross-reactivities in multiple sclerosis.,2024,10.1371/journal.ppat.1012177,https://pubmed.ncbi.nlm.nih.gov/38843296/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,42186619,"Genomic Characterization of Selected ESKAPEEE Clinical Isolates From Mbarara Regional Referral Hospital, Southwestern Uganda: Resistome, Multilocus Sequence Typing, Mobilome, and Virulome.",2026,10.7759/cureus.107624,https://pubmed.ncbi.nlm.nih.gov/42186619/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,40589572,Characterizing antimicrobial resistance and plasmidome diversity in &lt;i&gt;Escherichia coli&lt;/i&gt; from imported frozen broiler chicken in the United Arab Emirates.,2025,10.3389/fmicb.2025.1590906,https://pubmed.ncbi.nlm.nih.gov/40589572/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,34781974,Germline 3p22.1 microdeletion encompassing RPSA gene is an ultra-rare cause of isolated asplenia.,2021,10.1186/s13039-021-00571-0,https://pubmed.ncbi.nlm.nih.gov/34781974/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,33452580,Comparison Between Automated Office Blood Pressure Measurements and Manual Office Blood Pressure Measurements-Implications in Individual Patients: a Systematic Review and Meta-analysis.,2021,10.1007/s11906-020-01118-1,https://pubmed.ncbi.nlm.nih.gov/33452580/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,30970391,Comparisons between different blood pressure measurement techniques in patients with chronic kidney disease.,2019,10.23876/j.krcp.18.0109,https://pubmed.ncbi.nlm.nih.gov/30970391/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,31624333,Pharmacogenetic interactions in amyotrophic lateral sclerosis: a step closer to a cure?,2020,10.1038/s41397-019-0111-3,https://pubmed.ncbi.nlm.nih.gov/31624333/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,31108399,Modulation of MS-like disease by a multi epitope protein is mediated by induction of CD11c+CD11b+Gr1+ myeloid-derived dendritic cells.,2019,10.1016/j.jneuroim.2019.04.013,https://pubmed.ncbi.nlm.nih.gov/31108399/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,33358908,The molecular basis of gender disparities in smoking lung cancer patients.,2021,10.1016/j.lfs.2020.118927,https://pubmed.ncbi.nlm.nih.gov/33358908/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,22828087,The conventional versus automated measurement of blood pressure in the office (CAMBO) trial:  masked hypertension sub-study.,2012,10.1097/hjh.0b013e328356abd3,https://pubmed.ncbi.nlm.nih.gov/22828087/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,22752855,MOBP-specific cellular immune responses are weaker than MOG-specific cellular immune responses in patients with multiple sclerosis and healthy subjects.,2013,10.1007/s10072-012-1144-4,https://pubmed.ncbi.nlm.nih.gov/22752855/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,22117083,Conventional versus automated measurement of blood pressure in the office (CAMBO) trial.,2012,10.1093/fampra/cmr113,https://pubmed.ncbi.nlm.nih.gov/22117083/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MOBP,ENSG00000168314,Unsafe,31746776,Identification of functional tRNA-derived fragments in senescence-accelerated mouse prone 8 brain.,2019,10.18632/aging.102471,https://pubmed.ncbi.nlm.nih.gov/31746776/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORN3,ENSG00000139714,Unsafe,39054612,Identification of &lt;i&gt;MORN3&lt;/i&gt; and &lt;i&gt;LLGL2&lt;/i&gt; as novel diagnostic biomarkers for latent tuberculosis infection using machine learning strategies and experimental verification.,2024,10.1080/07853890.2024.2380797,https://pubmed.ncbi.nlm.nih.gov/39054612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORN3,ENSG00000139714,Unsafe,40294686,Integrated transcriptomic analysis reveals potential ceRNA network and hub genes involved in sex determination and differentiation of the Pacific oyster (Crassostrea gigas).,2025,10.1016/j.ijbiomac.2025.143551,https://pubmed.ncbi.nlm.nih.gov/40294686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORN3,ENSG00000139714,Unsafe,25248657,"Characterization of membrane occupation and recognition nexus repeat containing 3, meiosis expressed gene 1 binding partner, in mouse male germ cells.",2015,10.4103/1008-682x.138186,https://pubmed.ncbi.nlm.nih.gov/25248657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORN3,ENSG00000139714,Unsafe,35853971,Identification and validation of a novel 16-gene prognostic signature for patients with breast cancer.,2022,10.1038/s41598-022-16575-8,https://pubmed.ncbi.nlm.nih.gov/35853971/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORN3,ENSG00000139714,Unsafe,29681526,A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.,2018,10.1016/j.chembiol.2018.03.010,https://pubmed.ncbi.nlm.nih.gov/29681526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORN3,ENSG00000139714,Unsafe,30598658,The plasma peptides of ovarian cancer.,2018,10.1186/s12014-018-9215-z,https://pubmed.ncbi.nlm.nih.gov/30598658/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MORN3,ENSG00000139714,Unsafe,27106595,An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability.,2016,10.1007/s00439-016-1668-4,https://pubmed.ncbi.nlm.nih.gov/27106595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42510953,Imbalance of c-MPL Isoform Promotes Tumorigenesis by Activating STAT-5 in Leukemic Cell Lines.,2026,10.3390/cimb48070713,https://pubmed.ncbi.nlm.nih.gov/42510953/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,41243451,Non-muscle myosin IIA and IIB differentially affect the traffic and signalling of the thrombopoietin receptor.,2025,10.1242/jcs.264186,https://pubmed.ncbi.nlm.nih.gov/41243451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42459661,Reduced platelet count in mice protects against glucose intolerance and beta cell loss during a long-term high-fat diet.,2026,10.3389/fimmu.2026.1854992,https://pubmed.ncbi.nlm.nih.gov/42459661/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42435155,Dietary milk polar lipids ameliorate hepatic lipid accumulation through coordinated regulation of Wnt-PPARγ signaling and remodeling of the gut microbiota.,2026,10.1007/s44463-026-00100-w,https://pubmed.ncbi.nlm.nih.gov/42435155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42465767,Macrophage migration inhibitory factor in atrial fibrillation.,2026,10.3389/fimmu.2026.1874330,https://pubmed.ncbi.nlm.nih.gov/42465767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,40332017,Delineating Mpl-dependent and -independent phenotypes of Jak2 V617F-positive MPNs in vivo.,2025,10.1182/blood.2024026711,https://pubmed.ncbi.nlm.nih.gov/40332017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42689321,Targeting Thrombopoietin/MPL Signaling to Mitigate JAK2V617F-Driven Cardiac Microvascular Disease.,2026,10.1161/atvbaha.126.325061,https://pubmed.ncbi.nlm.nih.gov/42689321/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42725177,Multimodal optical imaging strategy to evaluate the microscopic biodistribution of SERS gold nanoparticles across histology sections.,2026,10.1117/1.bios.3.4.043104,https://pubmed.ncbi.nlm.nih.gov/42725177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42813103,Feasibility of label-free multiphoton luminescence imaging to track the fate of inhaled gold nanoparticles in &lt;i&gt;ex vivo&lt;/i&gt; lung tissue.,2026,10.1117/1.bios.3.4.043105,https://pubmed.ncbi.nlm.nih.gov/42813103/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42338948,MPL receptor dimerization and the thrombopoietin pathway in primary immune thrombocytopenia: from molecular mechanisms to targeted therapies.,2026,10.3389/fmed.2026.1798504,https://pubmed.ncbi.nlm.nih.gov/42338948/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42613432,Immunotherapeutic targeting of calreticulin mutant myeloproliferative neoplasms.,2026,10.1038/s41375-026-03115-w,https://pubmed.ncbi.nlm.nih.gov/42613432/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42488902,Translational rehabilitation strategies for canine medial patellar luxation: insights from human patellofemoral pain syndrome.,2026,10.3389/fvets.2026.1885078,https://pubmed.ncbi.nlm.nih.gov/42488902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42372951,Platelet Proteome Links Metabolism to Reactivity in Essential Thrombocythemia.,2026,10.1016/j.mcpro.2026.101617,https://pubmed.ncbi.nlm.nih.gov/42372951/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42384776,CAR T cell therapy selectively depletes disease-driving mutant calreticulin cells in xenotransplants and human organoid models of myelofibrosis.,2026,10.1126/scitranslmed.adz3553,https://pubmed.ncbi.nlm.nih.gov/42384776/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,39283476,A review on the functional characteristics of the c-Myeloproliferative Leukaemia (c-MPL) gene and its isoforms.,2024,10.1007/s13402-024-00988-w,https://pubmed.ncbi.nlm.nih.gov/39283476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42792882,The Roles of Genetic and Epigenetic Abnormalities in Essential Thrombocythemia.,2026,10.3390/genes17090989,https://pubmed.ncbi.nlm.nih.gov/42792882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42618917,"Morphometric assessment of the femoral trochlea, patella and patellar ligament in small breed dogs with and without grade II medial patellar luxation.",2026,10.1186/s12917-026-05816-x,https://pubmed.ncbi.nlm.nih.gov/42618917/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42811375,Megakaryocytes in myelofibrosis: mechanisms of fibrotic niche remodeling and therapeutic implications.,2026,10.1186/s40364-026-01003-0,https://pubmed.ncbi.nlm.nih.gov/42811375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,41185283,The influence of dietary structures composed of different fat globule interfaces on lipid metabolism in mice with a high-fat diet.,2025,10.1016/j.foodres.2025.117527,https://pubmed.ncbi.nlm.nih.gov/41185283/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42078644,C-MPL signaling in breast cancer: molecular mechanisms and therapeutic implications.,2026,10.1097/ms9.0000000000004894,https://pubmed.ncbi.nlm.nih.gov/42078644/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42650032,Inflammatory and Immune Microenvironment in Myeloproliferative Neoplasms: Pathogenic Mechanisms and Therapeutic Opportunities.,2026,10.3390/cancers18162718,https://pubmed.ncbi.nlm.nih.gov/42650032/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42624960,"Comparison of the adjuvant effect of AS01, AS03 and alum on the immune response to GMP-grade H5N1 antigen in guinea pigs.",2026,10.1038/s41598-026-65812-x,https://pubmed.ncbi.nlm.nih.gov/42624960/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42772472,Immunological evaluation of Brucella antigens formulated with two agonists of toll-like receptor 4 and 3 against brucellosis in BALB/c mice.,2026,10.1016/j.micpath.2026.108846,https://pubmed.ncbi.nlm.nih.gov/42772472/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42122287,Prospects of Chimeric Antigen Receptor T-Cell Therapy in Myelofibrosis: From Immunopathogenesis to Therapeutic Strategies.,2026,10.3390/cancers18091493,https://pubmed.ncbi.nlm.nih.gov/42122287/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42371171,Subthreshold micropulse laser for subretinal fluid after vitrectomy in myopic traction maculopathy: a pilot randomized controlled trial.,2026,10.1007/s10103-026-04929-x,https://pubmed.ncbi.nlm.nih.gov/42371171/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,41663574,Genetic variability in thrombopoietin receptor and GATA1 influences response to eltrombopag in dengue-induced thrombocytopenia.,2026,10.1038/s41598-026-37871-7,https://pubmed.ncbi.nlm.nih.gov/41663574/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,41048017,Comparative Cytokine and Histology Studies on HPV and Other Viral Vaccinations: No Pathogenicity of HPV Vaccine Adjuvants.,2025,10.1111/cas.70213,https://pubmed.ncbi.nlm.nih.gov/41048017/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42534944,KA101 outperforms other clinical adjuvants in inducing balanced Th1/Th2 immunity and robust B cell responses to varicella-zoster virus glycoprotein E.,2026,10.3389/fimmu.2026.1849099,https://pubmed.ncbi.nlm.nih.gov/42534944/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,40907461,Study on the adjuvant activity and mechanism of action of a novel Monophosphoryl Lipid A.,2025,10.1016/j.molimm.2025.08.019,https://pubmed.ncbi.nlm.nih.gov/40907461/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,41693158,Overcoming Challenges in Dengue Vaccine Development: Advanced Delivery Approaches.,2026,10.1021/acs.molpharmaceut.5c00937,https://pubmed.ncbi.nlm.nih.gov/41693158/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,41532194,A Murine Bispecific Antibody Efficiently Redirects T Cells Against Calr Mutated Stem Cells In Vivo.,2026,10.1002/ajh.70206,https://pubmed.ncbi.nlm.nih.gov/41532194/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42347631,Development and Preliminary Mechanistic Evaluation of a Novel Liposomal QS-21 and CpG ODNs Adjuvant System for Enhancing Vaccine Immunogenicity.,2026,10.3390/vaccines14060510,https://pubmed.ncbi.nlm.nih.gov/42347631/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42176570,Repurposing monepantel in oncology: A conceptual mini-review of proposed mechanisms.,2026,10.1016/j.biopha.2026.119528,https://pubmed.ncbi.nlm.nih.gov/42176570/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MPL,ENSG00000117400,Unsafe,42218860,BECC-adjuvanted hemagglutinin influenza vaccine promotes enhanced immunogenicity and protective efficacy.,2026,10.1016/j.vaccine.2026.128774,https://pubmed.ncbi.nlm.nih.gov/42218860/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MROH8,ENSG00000101353,Unsafe,39434688,METTL16 inhibits pancreatic cancer proliferation and metastasis by promoting MROH8 RNA stability and inhibiting CAPN2 expression - experimental studies.,2024,10.1097/js9.0000000000002116,https://pubmed.ncbi.nlm.nih.gov/39434688/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MROH8,ENSG00000101353,Unsafe,39412438,The clinical and genetic spectrum of paediatric speech and language disorders.,2025,10.1093/brain/awae264,https://pubmed.ncbi.nlm.nih.gov/39412438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MROH8,ENSG00000101353,Unsafe,32528873,Identifying Predictive Gene Expression and Signature Related to Temozolomide Sensitivity of Glioblastomas.,2020,10.3389/fonc.2020.00669,https://pubmed.ncbi.nlm.nih.gov/32528873/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPL30,ENSG00000185414,Unsafe,41723778,Unravelling Synaptic and Metabolic Mechanisms of Cognitive Resilience in Asymptomatic Alzheimer's Disease Across Two Alzheimer's Disease Cohorts.,2026,10.1007/s10571-026-01700-2,https://pubmed.ncbi.nlm.nih.gov/41723778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPL30,ENSG00000185414,Unsafe,41899471,Effects of Hybridization and Triploidization on Transcription of Core Metabolic and Stress Response Genes in Rainbow Trout (&lt;i&gt;Oncorhynchus mykiss&lt;/i&gt;) × Brook Trout (&lt;i&gt;Salvelinus fontinalis&lt;/i&gt;) Hybrids-Preliminary Results.,2026,10.3390/cimb48030320,https://pubmed.ncbi.nlm.nih.gov/41899471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPL30,ENSG00000185414,Unsafe,38086802,A novel microtubule inhibitor promotes tumor ferroptosis by attenuating SLC7A11/GPX4 signaling.,2023,10.1038/s41420-023-01713-6,https://pubmed.ncbi.nlm.nih.gov/38086802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPL30,ENSG00000185414,Unsafe,37079096,Cryostress induces fragmentation and alters the abundance of sperm transcripts associated with fertilizing competence and reproductive processes in buffalo.,2023,10.1007/s00441-023-03764-8,https://pubmed.ncbi.nlm.nih.gov/37079096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPL30,ENSG00000185414,Unsafe,34116718,Screening and identification of Theileria annulata subtelomere-encoded variable secreted protein-950454 (SVSP454) interacting proteins from bovine B cells.,2021,10.1186/s13071-021-04820-4,https://pubmed.ncbi.nlm.nih.gov/34116718/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPL30,ENSG00000185414,Unsafe,33542190,DNA methylation differences associated with social anxiety disorder and early life adversity.,2021,10.1038/s41398-021-01225-w,https://pubmed.ncbi.nlm.nih.gov/33542190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPL30,ENSG00000185414,Unsafe,28931599,"MrpL35, a mitospecific component of mitoribosomes, plays a key role in cytochrome c oxidase assembly.",2017,10.1091/mbc.e17-04-0239,https://pubmed.ncbi.nlm.nih.gov/28931599/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPL30,ENSG00000185414,Unsafe,24455749,Identifying candidate genes for Type 2 Diabetes Mellitus and obesity through gene expression profiling in multiple tissues or cells.,2013,10.1155/2013/970435,https://pubmed.ncbi.nlm.nih.gov/24455749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPL30,ENSG00000185414,Unsafe,19753307,"Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect.",2009,10.1371/journal.pone.0007033,https://pubmed.ncbi.nlm.nih.gov/19753307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPL30,ENSG00000185414,Unsafe,23922663,QTL analysis of dietary obesity in C57BL/6byj X 129P3/J F2 mice: diet- and sex-dependent effects.,2013,10.1371/journal.pone.0068776,https://pubmed.ncbi.nlm.nih.gov/23922663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPL30,ENSG00000185414,Unsafe,28978020,Mitochondrial biomarkers predict tumor progression and poor overall survival in gastric cancers: Companion diagnostics for personalized medicine.,2017,10.18632/oncotarget.19962,https://pubmed.ncbi.nlm.nih.gov/28978020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPS17,ENSG00000239789,Unsafe,42665721,TET1-mediated DNA demethylation and transcription activation of MRPS17 induces lung adenocarcinoma through PI3K-AKT-mTOR pathway.,2026,10.1007/s10735-026-10862-8,https://pubmed.ncbi.nlm.nih.gov/42665721/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPS17,ENSG00000239789,Unsafe,40201023,Mitochondrial Ribosomal Protein S17 Silencing Inhibits Proliferation and Invasiveness of Lung Cancer Cells.,2025,10.15430/jcp.24.023,https://pubmed.ncbi.nlm.nih.gov/40201023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPS17,ENSG00000239789,Unsafe,41675755,Identification of disulfidptosis-related genes in immunity and immunotherapy in diabetic foot ulcer.,2026,10.1097/ms9.0000000000003859,https://pubmed.ncbi.nlm.nih.gov/41675755/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPS17,ENSG00000239789,Unsafe,34234855,MRPS17 promotes invasion and metastasis through PI3K/AKT signal pathway and could be potential prognostic marker for gastric cancer.,2021,10.7150/jca.55719,https://pubmed.ncbi.nlm.nih.gov/34234855/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPS17,ENSG00000239789,Unsafe,36067173,Aberrant mitochondrial homeostasis at the crossroad of musculoskeletal ageing and non-small cell lung cancer.,2022,10.1371/journal.pone.0273766,https://pubmed.ncbi.nlm.nih.gov/36067173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPS17,ENSG00000239789,Unsafe,38577477,Identification of a novel inflammatory-related gene signature to evaluate the prognosis of gastric cancer patients.,2024,10.4251/wjgo.v16.i3.945,https://pubmed.ncbi.nlm.nih.gov/38577477/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPS17,ENSG00000239789,Unsafe,37407805,"The role of the mitochondrial ribosomal protein family in detecting hepatocellular carcinoma and predicting prognosis, immune features, and drug sensitivity.",2024,10.1007/s12094-023-03269-4,https://pubmed.ncbi.nlm.nih.gov/37407805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPS17,ENSG00000239789,Unsafe,33707953,Prognostic Value and Biological Functions of RNA Binding Proteins in Stomach Adenocarcinoma.,2021,10.2147/ott.s297973,https://pubmed.ncbi.nlm.nih.gov/33707953/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPS17,ENSG00000239789,Unsafe,33754151,Gene expression-based biomarkers designating glioblastomas resistant to multiple treatment strategies.,2021,10.1093/carcin/bgab024,https://pubmed.ncbi.nlm.nih.gov/33754151/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPS17,ENSG00000239789,Unsafe,33725943,Integration of summary data from GWAS and eQTL studies identified novel risk genes for coronary artery disease.,2021,10.1097/md.0000000000024769,https://pubmed.ncbi.nlm.nih.gov/33725943/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MRPS17,ENSG00000239789,Unsafe,25606410,De novo 393 kb microdeletion of 7p11.2 characterized by aCGH in a boy with psychomotor retardation and dysmorphic features.,2014,10.1016/j.mgene.2014.03.004,https://pubmed.ncbi.nlm.nih.gov/25606410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A14,ENSG00000166928,Unsafe,42441731,Integrative Transcriptome-Wide Association Study and Mendelian Randomization Identify LYNX1 and MS4A14 as Therapeutic Targets for Osteomyelitis.,2026,10.3791/70992,https://pubmed.ncbi.nlm.nih.gov/42441731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A14,ENSG00000166928,Unsafe,42567485,Tape-strip transcriptomics identify immune signatures in cutaneous T-cell lymphoma distinct from benign inflammatory skin diseases.,2026,10.1016/j.jaci.2026.07.019,https://pubmed.ncbi.nlm.nih.gov/42567485/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A14,ENSG00000166928,Unsafe,41533300,The MAD2L1-FOXM1 axis negatively regulates CD4⁺ T cell and macrophages infiltration in lung adenocarcinoma.,2026,10.1007/s12672-025-04360-8,https://pubmed.ncbi.nlm.nih.gov/41533300/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A14,ENSG00000166928,Unsafe,34346525,Differential expression and regulation of MS4A family members in myeloid cells in physiological and pathological conditions.,2022,10.1002/jlb.2a0421-200r,https://pubmed.ncbi.nlm.nih.gov/34346525/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A14,ENSG00000166928,Unsafe,40837069,Genome-Wide Association Study and Rare Variant Association Studies of Strabismus in the &lt;i&gt;All of Us&lt;/i&gt; Research Program.,2025,10.1016/j.xops.2025.100873,https://pubmed.ncbi.nlm.nih.gov/40837069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A14,ENSG00000166928,Unsafe,37533433,Role of the membrane-spanning 4A gene family in lung adenocarcinoma.,2023,10.3389/fgene.2023.1162787,https://pubmed.ncbi.nlm.nih.gov/37533433/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A14,ENSG00000166928,Unsafe,28971897,Subcellular localization of MS4A13 isoform 2 in mouse spermatozoa.,2017,10.1530/rep-17-0477,https://pubmed.ncbi.nlm.nih.gov/28971897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A14,ENSG00000166928,Unsafe,36226612,The transcriptional profiling identifies hub genes in immune subsets of patients with Behçet's syndrome.,2023,10.55563/clinexprheumatol/z4z0uj,https://pubmed.ncbi.nlm.nih.gov/36226612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A14,ENSG00000166928,Unsafe,24694585,cDNA cloning and localization of Sp3111 (also called Ms4a14) in the rat testis.,2014,10.1530/rep-14-0087,https://pubmed.ncbi.nlm.nih.gov/24694585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A14,ENSG00000166928,Unsafe,35651604,Development of a Phagocytosis-Dependent Gene Signature to Predict Prognosis and Response to Checkpoint Inhibition in Clear-Cell Renal Cell Carcinoma.,2022,10.3389/fimmu.2022.853088,https://pubmed.ncbi.nlm.nih.gov/35651604/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A14,ENSG00000166928,Unsafe,29756054,Distinct Expression and Prognostic Value of MS4A in Gastric Cancer.,2018,10.1515/med-2018-0028,https://pubmed.ncbi.nlm.nih.gov/29756054/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MS4A14,ENSG00000166928,Unsafe,31118907,Transcriptome Changes in Relation to Manic Episode.,2019,10.3389/fpsyt.2019.00280,https://pubmed.ncbi.nlm.nih.gov/31118907/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSANTD4,ENSG00000170903,Unsafe,38532337,LncRNA and mRNA expression characteristic and bioinformatic analysis in myocardium of diabetic cardiomyopathy mice.,2024,10.1186/s12864-024-10235-z,https://pubmed.ncbi.nlm.nih.gov/38532337/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSANTD4,ENSG00000170903,Unsafe,30885142,Genome-wide association study and scan for signatures of selection point to candidate genes for body temperature maintenance under the cold stress in Siberian cattle populations.,2019,10.1186/s12863-019-0725-0,https://pubmed.ncbi.nlm.nih.gov/30885142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,42381596,eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes.,2026,10.1002/advs.76264,https://pubmed.ncbi.nlm.nih.gov/42381596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,41257861,The role of DNA mismatch repair mutS/mutL homolog genes in spermatogenesis and male infertility: a systematic review and cohort study.,2025,10.1186/s12958-025-01493-x,https://pubmed.ncbi.nlm.nih.gov/41257861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,41746447,The DNA mismatch repair protein Msh4 is essential for meiosis of male but not for female in zebrafish.,2026,10.1007/s10577-026-09795-5,https://pubmed.ncbi.nlm.nih.gov/41746447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,42388729,Utilization of whole exome sequencing to identify hereditary mutations in Palestinian families with hereditary cancers.,2026,10.3389/fgene.2026.1779001,https://pubmed.ncbi.nlm.nih.gov/42388729/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,39734607,The Antioxidant and Anti-Inflammatory Impacts of Purple and White Eggplants on Fertility and Expression of Fertility-Related Genes in Rats Treated With Aluminum Chloride.,2024,10.1155/jt/8215321,https://pubmed.ncbi.nlm.nih.gov/39734607/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,39667087,Gonadal transcriptome analysis of Opsariichthys bidens reveals sex-associated genes.,2025,10.1016/j.cbd.2024.101379,https://pubmed.ncbi.nlm.nih.gov/39667087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,40461914,High-resolution optical genome mapping unveils gene disruptions in a reciprocal chromosomal translocation and severe male infertility: a case report.,2025,10.1007/s10815-025-03521-6,https://pubmed.ncbi.nlm.nih.gov/40461914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,38865271,RNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse.,2024,10.1073/pnas.2320995121,https://pubmed.ncbi.nlm.nih.gov/38865271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,40889571,"Epigenetic transgenerational effects of prenatal exposure to 2,2',4,4'-tetrabromodiphenyl ether on sperm function and DNA methylation in rat offspring.",2025,10.1016/j.fct.2025.115716,https://pubmed.ncbi.nlm.nih.gov/40889571/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,35090489,Novel bi-allelic MSH4 variants causes meiotic arrest and non-obstructive azoospermia.,2022,10.1186/s12958-022-00900-x,https://pubmed.ncbi.nlm.nih.gov/35090489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,39162221,Meiotic chromatin-associated HSF5 is indispensable for pachynema progression and male fertility.,2024,10.1093/nar/gkae701,https://pubmed.ncbi.nlm.nih.gov/39162221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,41150117,Multivariate Single-Step GWAS Reveals Pleiotropic Genomic Regions and Candidate Genes Associated with Male Scrotal Circumference and Female Fertility Traits in Retinta Beef Cattle.,2025,10.3390/vetsci12100977,https://pubmed.ncbi.nlm.nih.gov/41150117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,40319035,"EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA.",2025,10.1038/s41467-025-59470-2,https://pubmed.ncbi.nlm.nih.gov/40319035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,40896145,Genetic determinants of testicular sperm extraction outcomes: insights from a large multicentre study of men with non-obstructive azoospermia.,2025,10.1093/hropen/hoaf049,https://pubmed.ncbi.nlm.nih.gov/40896145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,41118211,HEIP1 orchestrates pro-crossover protein activity during mammalian meiosis.,2025,10.1073/pnas.2515747122,https://pubmed.ncbi.nlm.nih.gov/41118211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,37162286,Multi-omic analysis in normal colon organoids highlights MSH4 as a novel marker of defective mismatch repair in Lynch syndrome and microsatellite instability.,2023,10.1002/cam4.6048,https://pubmed.ncbi.nlm.nih.gov/37162286/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,37620942,Identification of compound heterozygous variants in MSH4 as a novel genetic cause of diminished ovarian reserve.,2023,10.1186/s12958-023-01127-0,https://pubmed.ncbi.nlm.nih.gov/37620942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,41148377,On site discrimination between two closely related commercial strains of oyster mushroom using a loop-mediated isothermal amplification (LAMP) test.,2025,10.1007/s11033-025-11156-0,https://pubmed.ncbi.nlm.nih.gov/41148377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,41911235,Mms4 chromosomal association reveals functional relationships between meiotic crossover pathways in budding yeast.,2026,10.1371/journal.pgen.1012097,https://pubmed.ncbi.nlm.nih.gov/41911235/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,38377115,"The DNA helicase FANCJ (BRIP1) functions in double strand break repair processing, but not crossover formation during prophase I of meiosis in male mice.",2024,10.1371/journal.pgen.1011175,https://pubmed.ncbi.nlm.nih.gov/38377115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,32221012,Complete response to anti-PD-L1 antibody in a metastatic bladder cancer associated with novel MSH4 mutation and microsatellite instability.,2020,10.1136/jitc-2019-000128,https://pubmed.ncbi.nlm.nih.gov/32221012/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,37833839,MSI-XGNN: an explainable GNN computational framework integrating transcription- and methylation-level biomarkers for microsatellite instability detection.,2023,10.1093/bib/bbad362,https://pubmed.ncbi.nlm.nih.gov/37833839/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,35079793,Comparative transcriptome analysis of genes and metabolic pathways involved in sporulation in Ganoderma lingzhi.,2022,10.1093/g3journal/jkab448,https://pubmed.ncbi.nlm.nih.gov/35079793/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,33448284,"Rare missense variant in MSH4 associated with primary gonadal failure in both 46, XX and 46, XY individuals.",2021,10.1093/humrep/deaa362,https://pubmed.ncbi.nlm.nih.gov/33448284/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,36816926,Construction of a DDR-related signature for predicting of prognosis in metastatic colorectal carcinoma.,2023,10.3389/fonc.2023.1043160,https://pubmed.ncbi.nlm.nih.gov/36816926/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,36765901,Novel Candidate loci and Pathogenic Germline Variants Involved in Familial Hematological Malignancies Revealed by Whole-Exome Sequencing.,2023,10.3390/cancers15030944,https://pubmed.ncbi.nlm.nih.gov/36765901/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,32915913,Novel genes associated with folic acid-mediated metabolism in mouse: A bioinformatics study.,2020,10.1371/journal.pone.0238940,https://pubmed.ncbi.nlm.nih.gov/32915913/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,29423084,Similarity and difference in tumor-infiltrating lymphocytes in original tumor tissues and those of in vitro expanded populations in head and neck cancer.,2018,10.18632/oncotarget.23454,https://pubmed.ncbi.nlm.nih.gov/29423084/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,32957448,Micronuclei Formation upon Radioiodine Therapy for Well-Differentiated Thyroid Cancer: The Influence of DNA Repair Genes Variants.,2020,10.3390/genes11091083,https://pubmed.ncbi.nlm.nih.gov/32957448/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,35377194,Association of Glyphosate Exposure with Blood DNA Methylation in a Cross-Sectional Study of Postmenopausal Women.,2022,10.1289/ehp10174,https://pubmed.ncbi.nlm.nih.gov/35377194/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,28728506,Microsatellite Instability and Promoter Hypermethylation of DNA repair genes in Hematologic Malignancies: a forthcoming direction toward diagnostics.,2018,10.1080/10245332.2017.1354428,https://pubmed.ncbi.nlm.nih.gov/28728506/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,23666334,"An MSH4 homolog, stpp1, from Pleurotus pulmonarius is a ""silver bullet"" for resolving problems caused by spores in cultivated mushrooms.",2013,10.1128/aem.00561-13,https://pubmed.ncbi.nlm.nih.gov/23666334/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,17409188,Role for Msh5 in the regulation of Ig class switch recombination.,2007,10.1073/pnas.0700815104,https://pubmed.ncbi.nlm.nih.gov/17409188/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,19050263,Reassessment of the role of Mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching.,2008,10.4049/jimmunol.181.12.8450,https://pubmed.ncbi.nlm.nih.gov/19050263/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,8637402,"Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.",1996,10.1016/0024-3205(96)00160-9,https://pubmed.ncbi.nlm.nih.gov/8637402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,33437391,A novel homozygous mutation in the meiotic gene MSH4 leading to male infertility due to non-obstructive azoospermia.,2020,,https://pubmed.ncbi.nlm.nih.gov/33437391/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSH4,ENSG00000057468,Unsafe,9299235,Cloning and expression analysis of a meiosis-specific MutS homolog: the human MSH4 gene.,1997,10.1006/geno.1997.4857,https://pubmed.ncbi.nlm.nih.gov/9299235/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42794491,Genome-Wide Characterization of the Myostatin Gene (MSTN) Ligand-Receptor System and Its Expression Patterns Associated with Growth Variation in &lt;i&gt;Trachinotus ovatus&lt;/i&gt;.,2026,10.3390/ijms27188061,https://pubmed.ncbi.nlm.nih.gov/42794491/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42663749,"Myostatin in fish: current understanding of its characterization, function, and signaling pathways.",2026,10.1007/s10695-026-01780-3,https://pubmed.ncbi.nlm.nih.gov/42663749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42393770,Alterations in systemic and skeletal muscle myostatin regulation are most prominent at disease onset and associate with muscle-related outcomes in idiopathic inflammatory myopathies.,2026,10.1186/s13075-026-03847-1,https://pubmed.ncbi.nlm.nih.gov/42393770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42670238,Safe and Stable Germline Transmission of MSTN Mutations in Cattle.,2026,10.1002/age.70192,https://pubmed.ncbi.nlm.nih.gov/42670238/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42708545,Comprehensive Analysis of miRNAs and Predicted Protein Interaction Networks in Skeletal Muscle Development of Myostatin-Deficient Rabbits.,2026,10.1002/age.70193,https://pubmed.ncbi.nlm.nih.gov/42708545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42123420,Myostatin Research: From Molecular Understanding to Clinical Translation for Musculoskeletal and Metabolic Disorders.,2026,10.3390/ijms27093836,https://pubmed.ncbi.nlm.nih.gov/42123420/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,41540153,A 90-day safety study of meat from MSTN gene-edited Mongolian cattle in mice.,2026,10.1038/s41598-025-31934-x,https://pubmed.ncbi.nlm.nih.gov/41540153/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,41600745,Serum Growth Differentiation Factor 8 (Myostatin) Concentrations in Cats with Early-Stage Chronic Kidney Disease.,2026,10.3390/vetsci13010089,https://pubmed.ncbi.nlm.nih.gov/41600745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42738422,Effects of Partial Myostatin Loss of Function on Carcass Yield and Meat Quality in Pigs Differing in IGF2 Genotype.,2026,10.3390/ani16172634,https://pubmed.ncbi.nlm.nih.gov/42738422/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42880944,Low-Intensity Pulsed Ultrasound Prevents Hypoxia-Induced Skeletal Muscle Atrophy in Association with HIF-1α Suppression.,2026,10.1002/jum.70489,https://pubmed.ncbi.nlm.nih.gov/42880944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42876031,Loss of Intestinal MSTN Promotes GLP-1 Secretion Through SGLT1 Palmitoylation.,2026,10.1002/advs.78302,https://pubmed.ncbi.nlm.nih.gov/42876031/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42337614,Accumulation of membrane repair-associated proteins and mature myostatin are novel markers of muscle pathophysiology in Pompe disease.,2026,10.1186/s40478-026-02348-1,https://pubmed.ncbi.nlm.nih.gov/42337614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,41899441,&lt;i&gt;MSTN&lt;/i&gt; and &lt;i&gt;TCF12&lt;/i&gt; as Candidate Immunometabolic Signatures in Glioma-Associated Foam Cells: Insights from Integrated Multi-Omics Analysis.,2026,10.3390/cimb48030289,https://pubmed.ncbi.nlm.nih.gov/41899441/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42746182,Retraction: GDF8 promotes the cell invasiveness in human trophoblasts by upregulating the expression of follistatin-like 3 through the ALK5-SMAD2/3 signaling pathway.,2026,10.3389/fcell.2026.1974410,https://pubmed.ncbi.nlm.nih.gov/42746182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,41249489,Pharmacological inhibition of myostatin effectively ameliorates osteolytic lesions in syngeneic and xenograft breast cancer mouse models.,2025,10.1038/s41388-025-03622-7,https://pubmed.ncbi.nlm.nih.gov/41249489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42343904,Clinical outcome of an SCNT-derived &lt;i&gt;MSTN&lt;/i&gt; knockout buffalo: a case study.,2026,10.3389/fgeed.2026.1822169,https://pubmed.ncbi.nlm.nih.gov/42343904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,41287261,Myostatin Exhibits an Evolutionarily Conserved Circadian Pattern in Skeletal Muscles.,2025,10.1002/jcsm.70130,https://pubmed.ncbi.nlm.nih.gov/41287261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42813516,&lt;i&gt;In Vitro&lt;/i&gt; Cellular Dynamics of Skin-Derived Fibroblasts of an MSTN&lt;sup&gt;-/-&lt;/sup&gt;Gene-Edited Buffalo.,2026,10.1177/21524971261492151,https://pubmed.ncbi.nlm.nih.gov/42813516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,41423190,Myostatin Function during In Vitro Myogenesis: Considerations for Knockout-Based Mechanistic Analysis.,2025,10.11005/jbm.25.915,https://pubmed.ncbi.nlm.nih.gov/41423190/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42664618,Type-specific and hibernation-associated skeletal muscle remodeling of the back muscle in Syrian hamsters.,2026,10.1016/j.jphyss.2026.100093,https://pubmed.ncbi.nlm.nih.gov/42664618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42777178,Clinical and Proteomic Biomarkers of Trifluridine/Tipiracil in Fluoropyrimidine-Refractory Advanced Pancreatic Adenocarcinoma: A Single-Arm Phase II Trial.,2026,10.1200/po-26-00323,https://pubmed.ncbi.nlm.nih.gov/42777178/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42752289,Precise resistance training alleviates osteosarcopenia via the GLP-1/myostatin path: a 32-week randomized controlled trial and molecular mechanism study.,2026,10.1080/13813455.2026.2734595,https://pubmed.ncbi.nlm.nih.gov/42752289/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,40360471,GDF8 and activin A are the key negative regulators of muscle mass in postmenopausal females: a randomized phase I trial.,2025,10.1038/s41467-025-59380-3,https://pubmed.ncbi.nlm.nih.gov/40360471/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,41888949,The effects of resistance training on myostatin in older adults with frailty and/or sarcopenia: a systematic review and meta analysis.,2026,10.1186/s13102-026-01655-3,https://pubmed.ncbi.nlm.nih.gov/41888949/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,41041909,Silencing Myostatin Using In Vivo Self-Assembled siRNA Protects Against Cancer- and Dexamethasone-Induced Muscle Atrophy.,2026,10.1002/adhm.202502186,https://pubmed.ncbi.nlm.nih.gov/41041909/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42353485,Defining the Impact of Genetics on Equine Performance and Development of Orthopaedic Disease.,2026,10.3390/ani16121875,https://pubmed.ncbi.nlm.nih.gov/42353485/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42106014,Single cell RNA sequencing revealed the mechanism underlying the increased osteogenic capacity of porcine BMSCs upon MSTN knockout.,2026,10.1016/j.gene.2026.150202,https://pubmed.ncbi.nlm.nih.gov/42106014/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,41907069,Harnessing myostatin pleiotropy for multitrait improvement via precision gene editing.,2026,10.3389/fgeed.2026.1749445,https://pubmed.ncbi.nlm.nih.gov/41907069/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,41432033,Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs.,2025,10.1093/nar/gkaf1374,https://pubmed.ncbi.nlm.nih.gov/41432033/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42519492,Production of gene-edited cloned cattle embryos using the CRISPR/EOCas12i system.,2026,10.3389/fgeed.2026.1891100,https://pubmed.ncbi.nlm.nih.gov/42519492/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,41423189,Emerging Role of Myostatin Inhibitors in the Management of Glucagon-Like Peptide-1-Associated Sarcopenia and Metabolic Disorders.,2025,10.11005/jbm.25.919,https://pubmed.ncbi.nlm.nih.gov/41423189/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42304819,3D skeletal muscle model recapitulating the myostatin knockout phenotypic and mitochondrial metabolic features.,2026,10.14814/phy2.70947,https://pubmed.ncbi.nlm.nih.gov/42304819/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,42791804,"Effects of Dietary Copper on Growth Performance, Antioxidant Capacity, Muscle Quality and the Expression of Copper-Transport and Muscle Development-Related Genes in Juvenile Red Swamp Crayfish (&lt;i&gt;Procambarus clarkii&lt;/i&gt;).",2026,10.3390/ani16182949,https://pubmed.ncbi.nlm.nih.gov/42791804/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MSTN,ENSG00000138379,Unsafe,41876797,Active immunization against myostatin and activin A improves skeletal muscle performance in growth hormone-deficient mice.,2026,10.1007/s11357-026-02207-w,https://pubmed.ncbi.nlm.nih.gov/41876797/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTCL3,ENSG00000214338,Unsafe,25015694,A genome-wide association study to identify genomic modulators of rate control therapy in patients with atrial fibrillation.,2014,10.1016/j.amjcard.2014.05.040,https://pubmed.ncbi.nlm.nih.gov/25015694/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,42762315,Clinicopathological significance and prognostic value of the MSI1/MTFR2 axis in clear cell renal cell carcinoma: linking stemness and mitochondrial dynamics.,2026,10.1007/s00795-026-00476-0,https://pubmed.ncbi.nlm.nih.gov/42762315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,42180857,"MTFR2 regulated the proliferation, apoptosis, migration, and invasion of endometrial cancer cells through the Drp1/MFN1 signaling pathway mediated mitochondrial fission.",2026,10.21037/tcr-2025-1-2793,https://pubmed.ncbi.nlm.nih.gov/42180857/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,42161922,MTFR2 promotes VDAC1 oligomerization to reprogram BCAA metabolism in tumor cells to polarize TAMs in LUAD.,2026,10.1038/s41419-026-08871-2,https://pubmed.ncbi.nlm.nih.gov/42161922/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,42134202,The astragaloside-brucea javanica oil nanoemulsion inhibiting the progression of oral squamous cell carcinoma through CDK1- HOXC10-MTFR2 pathway.,2026,10.1016/j.bioorg.2026.109983,https://pubmed.ncbi.nlm.nih.gov/42134202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,40563088,"Mitochondrial fission regulator 2 promotes cell proliferation, migration and invasion in hepatocellular carcinoma through regulating PI3K/AKT signaling pathway.",2025,10.1186/s13008-025-00160-2,https://pubmed.ncbi.nlm.nih.gov/40563088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,40129972,MTFR2 promotes endometrial carcinoma cell proliferation and growth via the miR-132-3p/PI3K/Akt signaling pathway.,2024,10.3389/fmed.2024.1505071,https://pubmed.ncbi.nlm.nih.gov/40129972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,42034032,Targeted nanoemulsion Blocks MTFR2-HIF-1α-EZH2/FoxM1 axis to suppress tongue squamous cell carcinoma invasion and metastasis.,2026,10.1016/j.phymed.2026.158196,https://pubmed.ncbi.nlm.nih.gov/42034032/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,40748969,"Mechanism of Astragaloside-Brucea javanica oil nanoemulsion against oral squamous cell carcinoma through CDK1/MTFR2: Network pharmacology, bioinformatics, and experimental studies.",2025,10.1371/journal.pone.0329622,https://pubmed.ncbi.nlm.nih.gov/40748969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,40365837,MTFR2-Mediated Fission Drives Fatty Acid and Mitochondrial Co-Transfer from Hepatic Stellate Cells to Tumor Cells Fueling Oncogenesis.,2025,10.1002/advs.202416419,https://pubmed.ncbi.nlm.nih.gov/40365837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,41282991,Identification of mitochondrial-related genes to evaluate the immune infiltration and prognosis of lung adenocarcinoma.,2025,10.7717/peerj.20262,https://pubmed.ncbi.nlm.nih.gov/41282991/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,41300981,Whole-Exome Sequencing-Based Linkage Analysis of Multiple Myeloma (MM) and Monoclonal Gammopathy of Undetermined Significance (MGUS) Pedigrees.,2025,10.3390/cancers17223611,https://pubmed.ncbi.nlm.nih.gov/41300981/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,39871949,"Brucea javanica oil inhibited the proliferation, migration, and invasion of oral squamous carcinoma by regulated the MTFR2 pathway.",2024,10.3389/fonc.2024.1477293,https://pubmed.ncbi.nlm.nih.gov/39871949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,37903059,"Dysregulation of MTFR2, ATP5IF1 and BAK1 in Sertoli cells relates to idiopathic non-obstructive azoospermia via inhibiting mitochondrial fission and inducing mitochondrial dysfunction†.",2024,10.1093/biolre/ioad150,https://pubmed.ncbi.nlm.nih.gov/37903059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,39182591,MTFR2 accelerates hepatocellular carcinoma mediated by metabolic reprogramming via the Akt signaling pathway.,2024,10.1016/j.cellsig.2024.111366,https://pubmed.ncbi.nlm.nih.gov/39182591/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,38238834,MTFR2-dependent mitochondrial fission promotes HCC progression.,2024,10.1186/s12967-023-04845-6,https://pubmed.ncbi.nlm.nih.gov/38238834/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,36713263,MTFR2 shapes a barrier of immune microenvironment in hepatocellular carcinoma.,2023,10.1016/j.isci.2022.105095,https://pubmed.ncbi.nlm.nih.gov/36713263/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,35047451,Association of High Expression of Mitochondrial Fission Regulator 2 with Poor Survival of Patients with Esophageal Squamous Cell Carcinoma.,2021,10.15430/jcp.2021.26.4.250,https://pubmed.ncbi.nlm.nih.gov/35047451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,34523692,"Transcription factor HOXC10 activates the expression of MTFR2 to regulate the proliferation, invasion and migration of colorectal cancer cells.",2021,10.3892/mmr.2021.12437,https://pubmed.ncbi.nlm.nih.gov/34523692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,35600359,Prognostic Value and Potential Mechanism of MTFR2 in Lung Adenocarcinoma.,2022,10.3389/fonc.2022.832517,https://pubmed.ncbi.nlm.nih.gov/35600359/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,34039308,Evaluation of clinical value and potential mechanism of MTFR2 in lung adenocarcinoma via bioinformatics.,2021,10.1186/s12885-021-08378-3,https://pubmed.ncbi.nlm.nih.gov/34039308/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,33995638,"MTFR2, A Potential Biomarker for Prognosis and Immune Infiltrates, Promotes Progression of Gastric Cancer Based on Bioinformatics Analysis and Experiments.",2021,10.7150/jca.58158,https://pubmed.ncbi.nlm.nih.gov/33995638/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,37903971,"Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma.",2023,10.1038/s41598-023-46057-4,https://pubmed.ncbi.nlm.nih.gov/37903971/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,32537437,"MTFR2 Promotes the Proliferation, Migration, and Invasion of Oral Squamous Carcinoma by Switching OXPHOS to Glycolysis.",2020,10.3389/fonc.2020.00858,https://pubmed.ncbi.nlm.nih.gov/32537437/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,33718103,Identification of Immune-Related Therapeutically Relevant Biomarkers in Breast Cancer and Breast Cancer Stem Cells by Transcriptome-Wide Analysis: A Clinical Prospective Study.,2020,10.3389/fonc.2020.554138,https://pubmed.ncbi.nlm.nih.gov/33718103/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTFR2,ENSG00000146410,Unsafe,29423030,Targeting dual specificity protein kinase TTK attenuates tumorigenesis of glioblastoma.,2018,10.18632/oncotarget.23152,https://pubmed.ncbi.nlm.nih.gov/29423030/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNAP1,ENSG00000141219,Unsafe,41720819,Variants in MTNAP1 underlie a neurodegenerative disorder by impairing mitochondrial stability.,2026,10.1038/s41525-026-00554-3,https://pubmed.ncbi.nlm.nih.gov/41720819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,42029548,Melatonin Receptor 1 and Melatonin Receptor 2 Expression During Human Kidney Development and Their Association with CAKUT.,2026,10.3390/jdb14020018,https://pubmed.ncbi.nlm.nih.gov/42029548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,42286740,Hierarchical Disruption of the Tryptophan-Melatonin Axis Contributes to Glioma Progression Through AKT/ERK/STAT3 Signalling.,2026,10.1111/jcmm.71243,https://pubmed.ncbi.nlm.nih.gov/42286740/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,42104152,Immunohistochemical expression of pancreatic melatonin receptor (MTNR1B) under experimental sleep disturbance in rats.,2026,10.1007/s10735-026-10817-z,https://pubmed.ncbi.nlm.nih.gov/42104152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,42650241,Molecular Characterization of Melatonin Receptors in &lt;i&gt;Perccottus glenii&lt;/i&gt; and Its Potential Roles in Melatonin-Mediated Antioxidant and Anti-Inflammatory Responses During Post-Freezing Recovery.,2026,10.3390/antiox15080978,https://pubmed.ncbi.nlm.nih.gov/42650241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,42883720,Circadian Misalignment and Chrononutrition in Type 2 Diabetes: Mechanistic Insights and Translational Gaps.,2026,10.3390/ijms27198473,https://pubmed.ncbi.nlm.nih.gov/42883720/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,41345649,Loss of melatonin signaling increases the risk of T2DM caused by metabolic disorders.,2025,10.1186/s12964-025-02539-8,https://pubmed.ncbi.nlm.nih.gov/41345649/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,42346809,"Melatonin Impairs Glucose Tolerance, First-Phase Insulin Secretion, and Insulin Feedback Inhibition; Interaction With MTNR1B Diabetes Risk Variant.",2026,10.2337/dc26-0164,https://pubmed.ncbi.nlm.nih.gov/42346809/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,40510472,Pharmacological modulation of MRAP2 protein on murine melatonin receptor signaling.,2025,10.3389/fendo.2025.1593345,https://pubmed.ncbi.nlm.nih.gov/40510472/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,42521769,Interaction of melatonin receptor 1B (MTNR1B) genotype and type of breakfast (protein-enriched v carbohydrate-rich) on postprandial glucose response: a randomised crossover trial.,2026,10.1038/s41430-026-01794-3,https://pubmed.ncbi.nlm.nih.gov/42521769/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,42375481,Shared genetic architecture between psychiatric and insulin-related traits in the general population.,2026,10.1016/j.nsa.2026.107017,https://pubmed.ncbi.nlm.nih.gov/42375481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,40736027,Evaluating the Role of PD1 and MTNR1B Gene Variants in Breast Cancer Susceptibility: A Case-Control Study in Bangladesh.,2025,10.1002/jcla.70086,https://pubmed.ncbi.nlm.nih.gov/40736027/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,40332199,Association of &lt;i&gt;MTNR1B&lt;/i&gt; Gene Polymorphisms with Body Mass Index in Hashimoto's Thyroiditis.,2025,10.3390/ijms26083667,https://pubmed.ncbi.nlm.nih.gov/40332199/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,41898821,"Gestational Diabetes and Genetics: &lt;i&gt;MTNR1B&lt;/i&gt;, &lt;i&gt;CDKAL1&lt;/i&gt;, and &lt;i&gt;IRS1&lt;/i&gt; as Critical Players.",2026,10.3390/genes17030287,https://pubmed.ncbi.nlm.nih.gov/41898821/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,42707754,Ferroptosis-driven stromal immune evasion and melatonin receptor suppression as novel predictive biomarkers of immunotherapy response in oral squamous cell carcinoma: a single-cell transcriptomic study.,2026,10.3389/fgene.2026.1911302,https://pubmed.ncbi.nlm.nih.gov/42707754/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,40898610,Modeling Genetic Risk of β-Cell Dysfunction in Human Induced Pluripotent Stem Cells From Patients Carrying the MTNR1B Risk Variant.,2025,10.1111/jpi.70073,https://pubmed.ncbi.nlm.nih.gov/40898610/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,37878614,Expression and role of melatonin membrane receptors in the hypothalamic-pituitary-testicular axis of Tibetan sheep in a plateau pastoral area.,2023,10.1371/journal.pone.0290775,https://pubmed.ncbi.nlm.nih.gov/37878614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,42173832,Genetic variants affect diurnal glucose levels throughout the day.,2026,10.1038/s41467-026-72432-6,https://pubmed.ncbi.nlm.nih.gov/42173832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,41579700,Altered placental expression of neurotransmitter and stress-related molecules in first-episode psychosis during pregnancy: Implications for cytoarchitecture and function.,2026,10.1016/j.psyneuen.2026.107751,https://pubmed.ncbi.nlm.nih.gov/41579700/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,40467595,MTNR1B variants increase gestational diabetes mellitus risk in young Chinese pregnant women.,2025,10.1038/s41598-025-02248-9,https://pubmed.ncbi.nlm.nih.gov/40467595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,40953972,Association of &lt;i&gt;MTNR1B&lt;/i&gt; polymorphisms with gestational diabetes mellitus and its interaction with pre-pregnancy body mass index in Northern Han Chinese women.,2025,10.1080/14767058.2025.2560936,https://pubmed.ncbi.nlm.nih.gov/40953972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,42834862,"Genetics-Informed Pharmacological Intervention in Gestational Diabetes Mellitus: Current Therapeutic Alignment, Emerging Targets and a Translational Roadmap.",2026,10.1111/dom.71404,https://pubmed.ncbi.nlm.nih.gov/42834862/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,41350307,"Discovering bioactive pharmaceuticals from natural products for type 2 diabetes mellitus using network pharmacology, molecular docking, and molecular dynamics.",2025,10.1038/s41598-025-27173-9,https://pubmed.ncbi.nlm.nih.gov/41350307/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,40697662,MT2 receptor mediates melatonin-induced thermogenic program in human myoblasts: insights for circadian syndrome and diabesity treatment.,2025,10.3389/fphar.2025.1633326,https://pubmed.ncbi.nlm.nih.gov/40697662/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,41827940,Association of Genetic Polymorphisms with Gestational Diabetes in a Kazakh Population: A Case-Control Study.,2026,10.3390/diagnostics16050663,https://pubmed.ncbi.nlm.nih.gov/41827940/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,41858338,Deciphering diabetes-related genetic markers using &lt;i&gt;in silico&lt;/i&gt; methods: insights into &lt;i&gt;Gymnema sylvestre&lt;/i&gt;'s therapeutic role for diabetes mellitus.,2026,10.1007/s40203-025-00483-6,https://pubmed.ncbi.nlm.nih.gov/41858338/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,37980891,MTNR1B rs1387153 Polymorphism and Risk of Gestational Diabetes Mellitus: Meta-Analysis and Trial Sequential Analysis.,2023,10.1159/000535148,https://pubmed.ncbi.nlm.nih.gov/37980891/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,40698944,Adolescent dietary patterns and methyl-donor nutrient intakes in relation to blood leukocyte DNA methylation of circadian genes.,2025,10.1080/07420528.2025.2532796,https://pubmed.ncbi.nlm.nih.gov/40698944/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,40399988,Exploring the genomic and transcriptomic profiles of glycemic traits and drug repurposing.,2025,10.1186/s12929-025-01137-7,https://pubmed.ncbi.nlm.nih.gov/40399988/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,38052941,MTNR1B genotype and effects of carbohydrate quantity and dietary glycaemic index on glycaemic response to an oral glucose load: the OmniCarb trial.,2024,10.1007/s00125-023-06056-6,https://pubmed.ncbi.nlm.nih.gov/38052941/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,42482087,Genomic and lipidomic analysis reveals lipid mediation of genetic risk in gestational diabetes.,2026,10.1186/s12916-026-05083-5,https://pubmed.ncbi.nlm.nih.gov/42482087/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,39011323,Diabetes-associated Genetic Variation in &lt;i&gt;MTNR1B&lt;/i&gt; and Its Effect on Islet Function.,2024,10.1210/jendso/bvae130,https://pubmed.ncbi.nlm.nih.gov/39011323/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTNR1B,ENSG00000134640,Unsafe,7568007,Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.,1995,10.1073/pnas.92.19.8734,https://pubmed.ncbi.nlm.nih.gov/7568007/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,41998764,MTSS1-dependent ubiquitin modifications mediated by FBXO44 remodel the actin cytoskeleton to promote gastric cancer progression.,2026,10.1186/s12943-026-02668-9,https://pubmed.ncbi.nlm.nih.gov/41998764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,42777454,A potential new biomarker in lip cancer: Metastasis suppressor protein 1 (MTSS1).,2026,10.1016/j.archoralbio.2026.106765,https://pubmed.ncbi.nlm.nih.gov/42777454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,41108838,Reduced Expression of MTSS1 Increases Sarcomere Number and Improves Contractility in Select Forms of Monogenic DCM.,2025,10.1016/j.jacbts.2025.101391,https://pubmed.ncbi.nlm.nih.gov/41108838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,39625546,MTSS1: beyond the integration of actin and membrane dynamics.,2024,10.1007/s00018-024-05511-w,https://pubmed.ncbi.nlm.nih.gov/39625546/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,41288860,PKCγ-mediated Phosphorylation of Mtss1 Regulates the Dendritic Outgrowth and Spine Development of Cerebellar Purkinje Cells.,2025,10.1007/s12035-025-05526-9,https://pubmed.ncbi.nlm.nih.gov/41288860/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,41298045,Decoding MTSS1: Turning Genetic Clues into Cardiac Cures.,2025,10.1016/j.jacbts.2025.101412,https://pubmed.ncbi.nlm.nih.gov/41298045/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,40507797,"Association of Functional Gene Variants in DYSF-ZNF638, MTSS1 and Ferroptosis-Related Genes with Multiple Sclerosis Severity and Target Gene Expression.",2025,10.3390/ijms26114986,https://pubmed.ncbi.nlm.nih.gov/40507797/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,39519115,SNHG15 Mediates MTSS1 Gene Expression via Interacting with the Gene Promoter and Regulating Transcription Pausing.,2024,10.3390/ijms252111565,https://pubmed.ncbi.nlm.nih.gov/39519115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,39527655,Sex-Specific Effects of &lt;i&gt;MTSS1&lt;/i&gt; Downregulation on Dilated Cardiomyopathy.,2024,10.1161/circulationaha.124.070418,https://pubmed.ncbi.nlm.nih.gov/39527655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,42303830,GWAS meta-analysis provides new insights into uveal melanoma risk.,2026,10.1038/s41416-026-03499-7,https://pubmed.ncbi.nlm.nih.gov/42303830/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,42902153,Seasonal regulation of mRNAs and lncRNAs under cold exposure favours metabolic and immune-related pathways in Sahiwal Cattle.,2026,10.1186/s12864-026-13223-7,https://pubmed.ncbi.nlm.nih.gov/42902153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,38526535,"Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1.",2024,10.7554/elife.96891,https://pubmed.ncbi.nlm.nih.gov/38526535/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,40066676,Arid4a Suppresses Breast Tumor Metastasis by Enhancing MTSS1 Expression via mRNA Stability.,2025,10.1002/cam4.70732,https://pubmed.ncbi.nlm.nih.gov/40066676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,37920825,MTSS1 is downregulated in nasopharyngeal carcinoma (NPC) which disrupts adherens junctions leading to enhanced cell migration and invasion.,2023,10.3389/fcell.2023.1275668,https://pubmed.ncbi.nlm.nih.gov/37920825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,38443233,A potential new biomarker in HNSCC: metastasis suppressor protein 1 (MTSS1).,2024,10.1016/j.oooo.2023.12.795,https://pubmed.ncbi.nlm.nih.gov/38443233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,39718666,Effect of D-amino acid metabolic enzyme deficiency on cancer development-diffuse large B-cell lymphoma onset and gene expression analyses in DASPO-knockout mice.,2024,10.1007/s00726-024-03426-1,https://pubmed.ncbi.nlm.nih.gov/39718666/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,41591360,MIM triggers formin to Arp2/3-based actin assembly in membrane remodeling in Drosophila embryos.,2026,10.1083/jcb.202502184,https://pubmed.ncbi.nlm.nih.gov/41591360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,40446975,Compound kushen injection inhibits breast cancer lung metastasis through regulating MTSS1/ARPC3/F-actin.,2025,10.1016/j.jep.2025.120054,https://pubmed.ncbi.nlm.nih.gov/40446975/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,39375267,Retraction Note: MicroRNA-411 promoted the osteosarcoma progression by suppressing MTSS1 expression.,2024,10.1007/s11356-024-35247-w,https://pubmed.ncbi.nlm.nih.gov/39375267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,38711908,Association of rs35006907 Polymorphism with Risk of Dilated Cardiomyopathy in Han Chinese Population.,2023,10.2478/bjmg-2023-0004,https://pubmed.ncbi.nlm.nih.gov/38711908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,36810288,MTSS1 curtails lung adenocarcinoma immune evasion by promoting AIP4-mediated PD-L1 monoubiquitination and lysosomal degradation.,2023,10.1038/s41421-022-00507-x,https://pubmed.ncbi.nlm.nih.gov/36810288/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,36496997,LINC00491 Facilitates Tumor Progression of Lung Adenocarcinoma via Wnt/β-Catenin-Signaling Pathway by Regulating MTSS1 Ubiquitination.,2022,10.3390/cells11233737,https://pubmed.ncbi.nlm.nih.gov/36496997/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,38200892,A Study of the Resistance of Hu Sheep Lambs to Escherichia coli F17 Based on Whole Genome Sequencing.,2024,10.3390/ani14010161,https://pubmed.ncbi.nlm.nih.gov/38200892/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,33782537,"Downregulation of MTSS1 in acute myeloid leukemia is associated with a poor prognosis, chemotherapy resistance, and disease aggressiveness.",2021,10.1038/s41375-021-01224-2,https://pubmed.ncbi.nlm.nih.gov/33782537/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,37687058,"(-)-Epicatechin Inhibits Metastatic-Associated Proliferation, Migration, and Invasion of Murine Breast Cancer Cells In Vitro.",2023,10.3390/molecules28176229,https://pubmed.ncbi.nlm.nih.gov/37687058/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,30530649,MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias.,2018,10.1073/pnas.1816177115,https://pubmed.ncbi.nlm.nih.gov/30530649/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,37270590,Genomic approaches to identify and investigate genes associated with atrial fibrillation and heart failure susceptibility.,2023,10.1186/s40246-023-00498-0,https://pubmed.ncbi.nlm.nih.gov/37270590/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,38859938,Genome-wide associations with longevity and reproductive traits in U.S. rangeland ewes.,2024,10.3389/fgene.2024.1398123,https://pubmed.ncbi.nlm.nih.gov/38859938/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,32726753,HDAC4 inhibition disrupts TET2 function in high-risk MDS and AML.,2020,10.18632/aging.103605,https://pubmed.ncbi.nlm.nih.gov/32726753/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,36338652,Prognostic value and immunological role of BAIAP2L2 in liver hepatocellular carcinoma: A pan-cancer analysis.,2022,10.3389/fsurg.2022.985034,https://pubmed.ncbi.nlm.nih.gov/36338652/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,33262521,Endocytosis: a pivotal pathway for regulating metastasis.,2021,10.1038/s41416-020-01179-8,https://pubmed.ncbi.nlm.nih.gov/33262521/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,35479408,Algorithmic reconstruction of glioblastoma network complexity.,2022,10.1016/j.isci.2022.104179,https://pubmed.ncbi.nlm.nih.gov/35479408/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,25996952,Identification of the Adapter Molecule MTSS1 as a Potential Oncogene-Specific Tumor Suppressor in Acute Myeloid Leukemia.,2015,10.1371/journal.pone.0125783,https://pubmed.ncbi.nlm.nih.gov/25996952/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MTSS1,ENSG00000170873,Unsafe,12082544,"MIM, a potential metastasis suppressor gene in bladder cancer.",2002,10.1038/sj.neo.7900231,https://pubmed.ncbi.nlm.nih.gov/12082544/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,42471244,A rare MYBL1-altered pediatric-type diffuse astrocytoma with positive OLIG2 and MAP2 expression and high proliferative activity.,2026,10.1093/jnen/nlag080,https://pubmed.ncbi.nlm.nih.gov/42471244/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,41772383,Immune Microenvironment Dynamics and Therapeutic Targets in GIST Revealed by Multi-Omics and Functional Validation.,2026,10.1111/jcmm.71069,https://pubmed.ncbi.nlm.nih.gov/41772383/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,39796135,Analyses of the MYBL1 Gene in Triple Negative Breast Cancer: Evidence of Regulation of the VCPIP1 Gene and Identification of a Specific Exon Overexpressed in Tumor Cell Lines.,2024,10.3390/ijms26010279,https://pubmed.ncbi.nlm.nih.gov/39796135/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,42315627,Comprehensive molecular characterization of treatment-free remission and molecular relapse in chronic myeloid leukemia patients: the EURO-SKI Biomarker Study.,2026,10.1038/s41375-026-03001-5,https://pubmed.ncbi.nlm.nih.gov/42315627/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,41281751,HDAC4/MybL1/YAP novel signaling axis is required for pancreatic cancer metastasis to the liver.,2025,10.7150/ijbs.102132,https://pubmed.ncbi.nlm.nih.gov/41281751/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,41663990,Sex-related differences in gene expression in early-stage bladder cancer revealed by whole-transcriptome sequencing.,2026,10.1186/s12885-026-15666-3,https://pubmed.ncbi.nlm.nih.gov/41663990/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,40263616,The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity.,2025,10.1038/s43587-025-00852-y,https://pubmed.ncbi.nlm.nih.gov/40263616/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,38797732,Downregulation of MYBL1 in endothelial cells contributes to atherosclerosis by repressing PLEKHM1-inducing autophagy.,2024,10.1007/s10565-024-09873-6,https://pubmed.ncbi.nlm.nih.gov/38797732/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,39422766,MYB/MYBL1-altered gliomas frequently harbor truncations and non-productive fusions in the MYB and MYBL1 genes.,2024,10.1007/s00401-024-02803-0,https://pubmed.ncbi.nlm.nih.gov/39422766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,41576835,"Evaluation of the diagnostic utility of an immunohistochemical panel (MYB, MYBL1, β-catenin, and LEF1) in basaloid tumors of the salivary glands.",2026,10.1016/j.anndiagpath.2026.152616,https://pubmed.ncbi.nlm.nih.gov/41576835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,41375020,"Bartholin Gland Carcinoma: A State-of-the-Art Review of Epidemiology, Histopathology, Molecular Testing, and Clinical Management.",2025,10.3390/cancers17233819,https://pubmed.ncbi.nlm.nih.gov/41375020/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,42510870,Integrated Bioinformatics and Machine Learning Analysis Identifies Inflammation-Related Biomarkers and Immune Infiltration Patterns in Atherosclerosis.,2026,10.3390/genes17070830,https://pubmed.ncbi.nlm.nih.gov/42510870/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,42608290,Paediatric-type diffuse low-grade gliomas: A pictorial review.,2026,10.1177/19714009261478303,https://pubmed.ncbi.nlm.nih.gov/42608290/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,41797214,Genomic and Transcriptomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes.,2026,10.1177/00220345261416398,https://pubmed.ncbi.nlm.nih.gov/41797214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,42094690,Integrated transcriptomic analysis identifies tsRNA-mRNA regulatory axis in asthma pathogenesis.,2026,10.1016/j.waojou.2026.101389,https://pubmed.ncbi.nlm.nih.gov/42094690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,39408891,Gene Expression Aberrations in Alcohol-Associated Hepatocellular Carcinoma.,2024,10.3390/ijms251910558,https://pubmed.ncbi.nlm.nih.gov/39408891/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,42180416,Metastatic adenoid cystic carcinoma of the Bartholin Gland: Institutional cases and literature review of a rare gynecologic malignancy.,2026,10.1016/j.gore.2026.102103,https://pubmed.ncbi.nlm.nih.gov/42180416/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,40702569,"The malignant transformation of an atypical angiocentric glioma, MYB-altered.",2025,10.1186/s40478-025-02070-4,https://pubmed.ncbi.nlm.nih.gov/40702569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,41591436,Pediatric low-grade epilepsy-associated tumors (LEATS): neuroimaging review and genetics update.,2026,10.1007/s00247-026-06519-z,https://pubmed.ncbi.nlm.nih.gov/41591436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,39508931,Targeted RNA Sequencing of Head and Neck Adenoid Cystic Carcinoma Reveals SEC16A::NOTCH1 Fusion and MET Exon 14 Skipping as Potentially Actionable Alterations.,2024,10.1007/s12105-024-01694-7,https://pubmed.ncbi.nlm.nih.gov/39508931/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,42310804,Leveraging tumor dynamics to discover mutations influencing progression and treatment response for precision oncology.,2026,10.1186/s13073-026-01695-x,https://pubmed.ncbi.nlm.nih.gov/42310804/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,40668344,"Illuminating radiogenomic signatures in pediatric-type diffuse gliomas: insights into molecular, clinical, and imaging correlations. Part II: low-grade group.",2025,10.1007/s11547-025-02049-0,https://pubmed.ncbi.nlm.nih.gov/40668344/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,41547215,A tailored histology-driven molecular profiling algorithm proposal for salivary gland cancers.,2026,10.1016/j.esmoop.2025.106033,https://pubmed.ncbi.nlm.nih.gov/41547215/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,40184085,Exploring potential treatment opportunities in a head and neck tumor patient with AdCC: A novel germline ERCC2 mutation case report.,2025,10.1097/md.0000000000041233,https://pubmed.ncbi.nlm.nih.gov/40184085/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,35987690,MYBL1 induces transcriptional activation of ANGPT2 to promote tumor angiogenesis and confer sorafenib resistance in human hepatocellular carcinoma.,2022,10.1038/s41419-022-05180-2,https://pubmed.ncbi.nlm.nih.gov/35987690/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,37476370,Salivary glands adenoid cystic carcinoma: a molecular profile update and potential implications.,2023,10.3389/fonc.2023.1191218,https://pubmed.ncbi.nlm.nih.gov/37476370/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,36591240,Integration analysis identifies MYBL1 as a novel immunotherapy biomarker affecting the immune microenvironment in clear cell renal cell carcinoma: Evidence based on machine learning and experiments.,2022,10.3389/fimmu.2022.1080403,https://pubmed.ncbi.nlm.nih.gov/36591240/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,38473786,Characterization of MYBL1 Gene in Triple-Negative Breast Cancers and the Genes' Relationship to Alterations Identified at the Chromosome 8q Loci.,2024,10.3390/ijms25052539,https://pubmed.ncbi.nlm.nih.gov/38473786/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,38835346,Emerging role of MYB transcription factors in cancer drug resistance.,2024,10.20517/cdr.2023.158,https://pubmed.ncbi.nlm.nih.gov/38835346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,38933947,Identification of therapeutic targets and medicines for comorbid Crohn's disease and rheumatoid arthritis: A comprehensive analysis.,2024,10.1016/j.heliyon.2024.e32406,https://pubmed.ncbi.nlm.nih.gov/38933947/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,37950087,From modulation of cellular plasticity to potentiation of therapeutic resistance: new and emerging roles of MYB transcription factors in human malignancies.,2024,10.1007/s10555-023-10153-8,https://pubmed.ncbi.nlm.nih.gov/37950087/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL1,ENSG00000185697,Unsafe,40861626,Pediatric-Type Diffuse Low-Grade Gliomas: A Subgroup Defined by Peculiar Molecular Features and Distinct Prognostic Outcomes.,2025,10.7759/cureus.88575,https://pubmed.ncbi.nlm.nih.gov/40861626/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,42819712,An IGF2BP2-MYBL2-HMGB2 Signaling Axis Promotes Macrophage Immune Evasion in Hepatocellular Carcinoma.,2026,10.34133/cancomm.0058,https://pubmed.ncbi.nlm.nih.gov/42819712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,42065054,Integrative Machine Learning and Experimental Validation Identify MYBL2 as a Prognostic Biomarker and Therapeutic Target in Hepatocellular Carcinoma.,2026,10.32604/or.2026.075284,https://pubmed.ncbi.nlm.nih.gov/42065054/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,42230547,MYBL2 impedes cisplatin sensitivity through suppressing GSDME-mediated pyroptosis in lung adenocarcinoma.,2026,10.1038/s41420-026-03175-y,https://pubmed.ncbi.nlm.nih.gov/42230547/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,42867919,Combined inhibition of DNA Polymerase Theta and ATR targets MYBL2-high triple-negative breast cancer stem cells.,2026,10.1172/jci202898,https://pubmed.ncbi.nlm.nih.gov/42867919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,42720907,MYBL2 promotes malignant phenotypes and M2-like macrophage polarization through CCL2 in non-small cell lung cancer.,2026,10.1007/s11010-026-05733-5,https://pubmed.ncbi.nlm.nih.gov/42720907/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,42143444,MYBL2 enhances salt tolerance via BES1-MYBL2-TPR3 module-mediated transcriptional repression.,2026,10.1016/j.bbrc.2026.153879,https://pubmed.ncbi.nlm.nih.gov/42143444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,41680840,"7,7""-dimethoxyagastisflavone induced MYCN/MYBL2-dependent apoptosis and metabolism reprogramming in Sonic Hedgehog medulloblastoma.",2026,10.1186/s12967-026-07809-8,https://pubmed.ncbi.nlm.nih.gov/41680840/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,42416217,Clinical Significance of Tumor Invasion Gene Profiling in Early-Stage Hormone Receptor-Positive Breast Cancer: A Cross-Sectional Study.,2026,10.1002/hsr2.72780,https://pubmed.ncbi.nlm.nih.gov/42416217/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,42010154,Zinc-dependent Zip7-MAZ-MYBL2 axis promotes prostate cancer metastasis.,2026,10.1038/s42003-026-10074-6,https://pubmed.ncbi.nlm.nih.gov/42010154/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,41866755,The MYBL2-GTSE1 axis promotes laryngeal squamous cell carcinoma progression by regulating PI3K/AKT-dependent glycolytic reprogramming.,2026,10.1080/15384047.2026.2648193,https://pubmed.ncbi.nlm.nih.gov/41866755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,41284124,CircFAT1(e2) acts as a sponge for miR-30e-5p and inhibits glioma progression by regulating MYBL2-mediated cell proliferation.,2025,10.1007/s12672-025-03851-y,https://pubmed.ncbi.nlm.nih.gov/41284124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,41388437,MYBL2 regulates the expression of CENPF in lung adenocarcinoma and promotes tumor development and metastasis through AKT pathway activation.,2025,10.1186/s40001-025-03648-3,https://pubmed.ncbi.nlm.nih.gov/41388437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,42899482,Tumour Antigen-Specific Antibody Signatures as Diagnostic Biomarkers for Melanoma.,2026,10.1002/ijc.70726,https://pubmed.ncbi.nlm.nih.gov/42899482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,42336904,"Integrated bioinformatics, machine learning, and experimental validation identify a four-gene diagnostic signature for cervical cancer associated with PI3K/AKT signaling.",2026,10.1038/s41598-026-57689-7,https://pubmed.ncbi.nlm.nih.gov/42336904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,42041682,A Pan-Cancer Transcriptomic Signature for Conserved Molecular Programs Underlying Premalignant-Malignant Progression Across Common Carcinomas.,2026,10.3390/dj14040228,https://pubmed.ncbi.nlm.nih.gov/42041682/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,42345518,MYBL2 Knockdown Enhances Ferroptosis and Bortezomib Sensitivity by Transcriptionally Regulating CDKN3 and Inactivating PI3K/Akt Signaling in Multiple Myeloma.,2026,10.1002/jbt.70990,https://pubmed.ncbi.nlm.nih.gov/42345518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,42310565,Correlated expression of MYBL2 and CCL5 defines an immunosuppressive microenvironment and predicts poor prognosis in intrahepatic cholangiocarcinoma.,2026,10.1186/s12885-026-16219-4,https://pubmed.ncbi.nlm.nih.gov/42310565/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,42882828,GAS5 Downregulation Promotes the Progression of Triple-Negative Breast Cancer by Regulating Tumor Cells-MDSCs Crosstalk.,2026,10.3390/cancers18193133,https://pubmed.ncbi.nlm.nih.gov/42882828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,41424740,Clinical Significance of MYBL2 Expression in Hepatocellular Carcinoma: Impact on Overall Survival.,2025,10.2147/ott.s555199,https://pubmed.ncbi.nlm.nih.gov/41424740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,42898284,GART expression is associated with a proliferative and purine-metabolic ISC-like epithelial state in ulcerative colitis.,2026,10.3389/fimmu.2026.1913904,https://pubmed.ncbi.nlm.nih.gov/42898284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,42594485,Hypoxia drives ferroptosis resistance and immunosuppression in hepatocellular carcinoma by inducing UBASH3B-mediated glutamine metabolism reprogramming and CXCL8 expression.,2026,10.1016/j.redox.2026.104342,https://pubmed.ncbi.nlm.nih.gov/42594485/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,41184628,Prognostic value of MYBL2 and its potential implications for immunotherapy: a study of bioinformatics and experimental validation.,2026,10.1038/s41416-025-03253-5,https://pubmed.ncbi.nlm.nih.gov/41184628/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,40885709,WEE1 inhibitor exerts synergistic effect with KRAS G12C inhibitor via MYBL2-RRM2 axis in KRAS&lt;sup&gt;G12C&lt;/sup&gt;-mutant lung cancer.,2025,10.1038/s41419-025-07992-4,https://pubmed.ncbi.nlm.nih.gov/40885709/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,40639849,Malevolent alliance of MYBL2&lt;sup&gt;hi&lt;/sup&gt; cancer stem cell and SPP1+ macrophage confers resistance to neoadjuvant immunotherapy in bladder cancer.,2025,10.1136/jitc-2024-011319,https://pubmed.ncbi.nlm.nih.gov/40639849/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,42003200,Toxicological Implications of m&lt;sup&gt;6&lt;/sup&gt;A Dysregulation: SH3PXD2A-AS1-Driven PD-L1 Overexpression Promotes Immune Evasion in NSCLC.,2026,10.1002/jbt.70784,https://pubmed.ncbi.nlm.nih.gov/42003200/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,40432915,MYB Proto-Oncogene Like 2 identified as a biomarker for uterine corpus endometrial carcinoma: evidence from bioinformatics and clinical validation.,2025,10.3389/fonc.2025.1595485,https://pubmed.ncbi.nlm.nih.gov/40432915/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,41612595,Polyhydroxyalkanoate Microspheres Promote Skin Regeneration by Activating the MYBL2 Transcription Factor.,2026,10.1002/adhm.202505030,https://pubmed.ncbi.nlm.nih.gov/41612595/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,41653034,SPP1&lt;sup&gt;+&lt;/sup&gt; Macrophage-POSTN&lt;sup&gt;+&lt;/sup&gt; Fibroblast-Endothelial Triad Dictates Immunotherapy Response in Bladder Cancer.,2026,10.1096/fj.202504456rr,https://pubmed.ncbi.nlm.nih.gov/41653034/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,41763168,A multi-omics R-loop-linked risk program highlights CKS2-positive proliferative tumor cells as drivers of glioma growth.,2026,10.1016/j.intimp.2026.116421,https://pubmed.ncbi.nlm.nih.gov/41763168/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,42511840,Integrated Transcriptomic Analysis of &lt;i&gt;NOTCH1-&lt;/i&gt; and &lt;i&gt;MYB&lt;/i&gt;-Associated Immune Features in SACC.,2026,10.3390/ijms27146498,https://pubmed.ncbi.nlm.nih.gov/42511840/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,41115880,Cell cycle regulator MYBL2 is a distinct vulnerability in acute myeloid leukemia.,2025,10.1038/s41420-025-02810-4,https://pubmed.ncbi.nlm.nih.gov/41115880/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,39139556,Case report: Dual-targeted BCMA and CS1 CAR-T-cell immunotherapy in recurrent and refractory extramedullary multiple myeloma.,2024,10.3389/fimmu.2024.1422478,https://pubmed.ncbi.nlm.nih.gov/39139556/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,41491570,Maternal undernutrition inhibits fetal rumen development: novel miRNA-736-mediated dual targeting of E2F2 and MYBL2 in sheep.,2026,10.1186/s40104-025-01321-7,https://pubmed.ncbi.nlm.nih.gov/41491570/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYBL2,ENSG00000101057,Unsafe,40092688,System Analysis Identifies MYBL2 As a Novel Oncogene Target for Metastatic Prostate Cancer.,2025,10.7150/jca.107232,https://pubmed.ncbi.nlm.nih.gov/40092688/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,42417609,Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia.,2026,10.7554/elife.110601,https://pubmed.ncbi.nlm.nih.gov/42417609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,40979936,Identification of Specific LncRNA Markers in Severe Tuberculosis for Early Diagnosis.,2025,10.2147/idr.s540446,https://pubmed.ncbi.nlm.nih.gov/40979936/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,39092789,MYCBPAP is a central apparatus protein required for centrosome-nuclear envelope docking and sperm tail biogenesis in mice.,2024,10.1242/jcs.261962,https://pubmed.ncbi.nlm.nih.gov/39092789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,41504506,"Genetic correlations among diaphragmatic, femoral, inguinal, ventral, and umbilical hernias and identification of their candidate genes.",2026,10.1097/js9.0000000000004699,https://pubmed.ncbi.nlm.nih.gov/41504506/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,39866192,"ArfGAP with the SH3 Domain, Ankyrin Repeat and PH Domain 1 Inversely Regulates Programmed Death-Ligand 1 Through Negative Feedback of Phosphorylated Epithelial Growth Factor Receptor and Activation of Nuclear Factor-Kappa B in Non-Small Cell Lung Cancer.",2025,10.2147/cmar.s493368,https://pubmed.ncbi.nlm.nih.gov/39866192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,39704931,"Homozygous deleterious variants in MYCBPAP induce asthenoteratozoospermia involving abnormal acrosome biogenesis, manchette structure and sperm tail assembly in humans and mice.",2025,10.1007/s11427-024-2757-7,https://pubmed.ncbi.nlm.nih.gov/39704931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,39853433,CFAP65 is essential for C2a projection integrity in axonemes: implications for organ-specific ciliary dysfunction and infertility.,2025,10.1007/s00018-025-05583-2,https://pubmed.ncbi.nlm.nih.gov/39853433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,37834383,ADP-Ribosylation Factor 6 Pathway Acts as a Key Executor of Mesenchymal Tumor Plasticity.,2023,10.3390/ijms241914934,https://pubmed.ncbi.nlm.nih.gov/37834383/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,34220948,Oncological Effects and Prognostic Value of AMAP1 in Gastric Cancer.,2021,10.3389/fgene.2021.675100,https://pubmed.ncbi.nlm.nih.gov/34220948/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,34742153,Dual roles of AMAP1 in the transcriptional regulation and intracellular trafficking of carbonic anhydrase IX.,2022,10.1016/j.tranon.2021.101258,https://pubmed.ncbi.nlm.nih.gov/34742153/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,35399607,CCL18 promotes breast cancer progression by exosomal miR-760 activation of ARF6/Src/PI3K/Akt pathway.,2022,10.1016/j.omto.2022.03.004,https://pubmed.ncbi.nlm.nih.gov/35399607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,32616903,The transcriptional signature associated with human motile cilia.,2020,10.1038/s41598-020-66453-4,https://pubmed.ncbi.nlm.nih.gov/32616903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,34001163,Inhibition of mutant KRAS-driven overexpression of ARF6 and MYC by an eIF4A inhibitor drug improves the effects of anti-PD-1 immunotherapy for pancreatic cancer.,2021,10.1186/s12964-021-00733-y,https://pubmed.ncbi.nlm.nih.gov/34001163/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,32580737,"High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer.",2020,10.1186/s12964-020-00608-8,https://pubmed.ncbi.nlm.nih.gov/32580737/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,35775252,[Arf6 regulates endometriotic epithelial-mesenchymal transition and mitochondrial distribution].,2022,10.3760/cma.j.cn112141-20220126-00050,https://pubmed.ncbi.nlm.nih.gov/35775252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,30509302,Epithelial-specific histone modification of the miR-96/182 locus targeting AMAP1 mRNA predisposes p53 to suppress cell invasion in epithelial cells.,2018,10.1186/s12964-018-0302-6,https://pubmed.ncbi.nlm.nih.gov/30509302/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,31399545,"ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer.",2019,10.1073/pnas.1901765116,https://pubmed.ncbi.nlm.nih.gov/31399545/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,29329590,"Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model.",2018,10.1186/s12964-017-0212-z,https://pubmed.ncbi.nlm.nih.gov/29329590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,28834540,CCL18-dependent translocation of AMAP1 is critical for epithelial to mesenchymal transition in breast cancer.,2018,10.1002/jcp.26164,https://pubmed.ncbi.nlm.nih.gov/28834540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,29992963,Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe.,2018,10.1038/s41467-018-05087-7,https://pubmed.ncbi.nlm.nih.gov/29992963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,22734003,Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion.,2012,10.1083/jcb.201201065,https://pubmed.ncbi.nlm.nih.gov/22734003/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,31089398,A Common Variant of ASAP1 Is Associated with Tuberculosis Susceptibility in the Han Chinese Population.,2019,10.1155/2019/7945429,https://pubmed.ncbi.nlm.nih.gov/31089398/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,16636290,Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.,2006,10.1073/pnas.0509166103,https://pubmed.ncbi.nlm.nih.gov/16636290/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYCBPAP,ENSG00000136449,Unsafe,12151104,"AMAP-1, a novel testis-specific AMY-1-binding protein, is differentially expressed during the course of spermatogenesis.",2002,10.1016/s0167-4781(02)00411-6,https://pubmed.ncbi.nlm.nih.gov/12151104/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,40506993,A Five-Gene Signature for the Prediction of Event-Free Survival of Both Pediatric and Adult Acute Myeloid Leukemia.,2025,10.3390/diagnostics15111421,https://pubmed.ncbi.nlm.nih.gov/40506993/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,41081085,Genetic modifiers of response to thalidomide in transfusion-dependent beta-thalassemia patients: a whole-exome sequence analysis.,2025,10.7717/peerj.20038,https://pubmed.ncbi.nlm.nih.gov/41081085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,40564006,Effect of Recombinant Human Growth Hormone (rhGH) Use on Genetic Methylation Patterns and Their Relationship with Body Composition in Small-for-Gestational-Age (SGA) Newborns.,2025,10.3390/biomedicines13061288,https://pubmed.ncbi.nlm.nih.gov/40564006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,39857271,Genome-Wide Scans for Selection Signatures in Haimen Goats Reveal Candidate Genes Associated with Growth Traits.,2025,10.3390/biology14010040,https://pubmed.ncbi.nlm.nih.gov/39857271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,37817112,MAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor.,2023,10.1186/s12885-023-11480-3,https://pubmed.ncbi.nlm.nih.gov/37817112/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,30836986,The ancient sarcomeric myosins found in specialized muscles.,2019,10.1186/s13395-019-0192-3,https://pubmed.ncbi.nlm.nih.gov/30836986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,40739960,Temporal Dynamics of Somatic Mutations in Tumor and Plasma Samples From Hepatocellular Carcinoma Patients Pre- and Post-Radioactive Particle Implantation: A Whole-Exome Sequencing Study.,2025,10.1002/bab.2792,https://pubmed.ncbi.nlm.nih.gov/40739960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,36824152,Mutational and Transcriptional Characterization Establishes Prognostic Models for Resectable Lung Squamous Cell Carcinoma.,2023,10.2147/cmar.s384918,https://pubmed.ncbi.nlm.nih.gov/36824152/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,30906771,Association Study of Myosin Heavy Chain 15 Polymorphisms with Asthma Susceptibility in Chinese Han.,2019,10.1155/2019/3805405,https://pubmed.ncbi.nlm.nih.gov/30906771/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,30967136,Novel potential causative genes in carotid paragangliomas.,2019,10.1186/s12881-019-0770-6,https://pubmed.ncbi.nlm.nih.gov/30967136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,30985904,Rare variants in MYH15 modify amyotrophic lateral sclerosis risk.,2019,10.1093/hmg/ddz063,https://pubmed.ncbi.nlm.nih.gov/30985904/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,32670085,Molecular Phenotyping of White Striping and Wooden Breast Myopathies in Chicken.,2020,10.3389/fphys.2020.00633,https://pubmed.ncbi.nlm.nih.gov/32670085/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,28235404,Progesterone signalling in broiler skeletal muscle is associated with divergent feed efficiency.,2017,10.1186/s12918-017-0396-2,https://pubmed.ncbi.nlm.nih.gov/28235404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,36978532,Identification of Candidate Genes and Functional Pathways Associated with Body Size Traits in Chinese Holstein Cattle Based on GWAS Analysis.,2023,10.3390/ani13060992,https://pubmed.ncbi.nlm.nih.gov/36978532/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,31113982,TGFβ-induced cytoskeletal remodeling mediates elevation of cell stiffness and invasiveness in NSCLC.,2019,10.1038/s41598-019-43409-x,https://pubmed.ncbi.nlm.nih.gov/31113982/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,19948655,Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles.,2010,10.1113/jphysiol.2009.181008,https://pubmed.ncbi.nlm.nih.gov/19948655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,25514360,Genome-Wide Association Study Identification of Novel Loci Associated with Airway Responsiveness in Chronic Obstructive Pulmonary Disease.,2015,10.1165/rcmb.2014-0198oc,https://pubmed.ncbi.nlm.nih.gov/25514360/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,32328350,Transcriptome for the breast muscle of Jinghai yellow chicken at early growth stages.,2020,10.7717/peerj.8950,https://pubmed.ncbi.nlm.nih.gov/32328350/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,27982099,Co-expression analysis and identification of fecundity-related long non-coding RNAs in sheep ovaries.,2016,10.1038/srep39398,https://pubmed.ncbi.nlm.nih.gov/27982099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYH15,ENSG00000144821,Unsafe,32724426,Genomic analysis of biomarkers related to the prognosis of acute myeloid leukemia.,2020,10.3892/ol.2020.11700,https://pubmed.ncbi.nlm.nih.gov/32724426/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,40822859,LncRNA &lt;i&gt;MYO16-AS1&lt;/i&gt; and &lt;i&gt;MICAL2&lt;/i&gt; axis sustains proliferation and migration in ovarian cancer cells and unveils a therapeutic vulnerability in patient-derived tumor organoids.,2025,10.1016/j.ncrna.2025.07.005,https://pubmed.ncbi.nlm.nih.gov/40822859/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,42316018,Expression dynamics during metamorphosis and genome-wide analysis of the myosin gene family in the Chinese mitten crab (Eriocheir sinensis).,2026,10.1186/s12864-026-13087-x,https://pubmed.ncbi.nlm.nih.gov/42316018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,41581355,Integrative genome-wide association study and transcriptomic analysis to identify candidate genes and pathways for heterophil and lymphocyte traits in white-feathered broilers.,2026,10.1016/j.psj.2026.106407,https://pubmed.ncbi.nlm.nih.gov/41581355/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,41429952,Hyperbilirubinemia and phototherapy differentially alter hippocampal transcriptome in the preterm Gunn rat model.,2026,10.1038/s41390-025-04700-y,https://pubmed.ncbi.nlm.nih.gov/41429952/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,38041756,Disrupting of IGF2BP3-stabilized HK2 mRNA by MYO16-AS1 competitively binding impairs LUAD migration and invasion.,2024,10.1007/s11010-023-04887-w,https://pubmed.ncbi.nlm.nih.gov/38041756/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,42278127,Genome-Wide Association Analysis of the Sperm Motility Traits of Jinding Drakes.,2026,10.3390/ani16111694,https://pubmed.ncbi.nlm.nih.gov/42278127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,40782499,Potential function exploration of lncRNAs in idiopathic pulmonary fibrosis: insights from whole transcriptome sequencing data analysis.,2025,10.1016/j.clinsp.2025.100732,https://pubmed.ncbi.nlm.nih.gov/40782499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,41137279,ZNF143 as a diagnostic biomarker: Insights from gene expression and immune cell infiltration in COPD and asthma.,2025,10.1097/md.0000000000045317,https://pubmed.ncbi.nlm.nih.gov/41137279/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,38732035,Unveiling the Genomic Landscape of Intraductal Carcinoma of the Prostate Using Spatial Gene Expression Analysis.,2024,10.3390/ijms25094818,https://pubmed.ncbi.nlm.nih.gov/38732035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,38933922,Construction of a ceRNA network and screening of potential biomarkers and molecular targets in male smokers with chronic obstructive pulmonary disease.,2024,10.3389/fgene.2024.1376721,https://pubmed.ncbi.nlm.nih.gov/38933922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,38438384,Genetic architecture of the structural connectome.,2024,10.1038/s41467-024-46023-2,https://pubmed.ncbi.nlm.nih.gov/38438384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,40228246,Construction of a prognostic model for autophagy-related LncRNAs in lung adenocarcinoma.,2025,10.1097/md.0000000000042122,https://pubmed.ncbi.nlm.nih.gov/40228246/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,39792988,Identification and validation of soft tissue sarcoma-specific transcriptomic model for predicting radioresistance.,2025,10.1080/09553002.2024.2447509,https://pubmed.ncbi.nlm.nih.gov/39792988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,32451869,Myosin XVI.,2020,10.1007/978-3-030-38062-5_18,https://pubmed.ncbi.nlm.nih.gov/32451869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,32824179,Myosin XVI in the Nervous System.,2020,10.3390/cells9081903,https://pubmed.ncbi.nlm.nih.gov/32824179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,33930467,"The C-terminal tail extension of myosin 16 acts as a molten globule, including intrinsically disordered regions, and interacts with the N-terminal ankyrin.",2021,10.1016/j.jbc.2021.100716,https://pubmed.ncbi.nlm.nih.gov/33930467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,39923055,Genetic determinants of skin ageing: a systematic review and meta-analysis of genome-wide association studies and candidate genes.,2025,10.1186/s40101-025-00384-9,https://pubmed.ncbi.nlm.nih.gov/39923055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,39543761,A genome-wide association study in Swedish colorectal cancer patients with gastric- and prostate cancer in relatives.,2024,10.1186/s13053-024-00299-z,https://pubmed.ncbi.nlm.nih.gov/39543761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,35368654,An Effective Hypoxia-Related Long Non-Coding RNA Assessment Model for Prognosis of Lung Adenocarcinoma.,2022,10.3389/fgene.2022.768971,https://pubmed.ncbi.nlm.nih.gov/35368654/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,36497289,Accurate Diagnosis and Survival Prediction of Bladder Cancer Using Deep Learning on Histological Slides.,2022,10.3390/cancers14235807,https://pubmed.ncbi.nlm.nih.gov/36497289/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,31474830,Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization.,2019,10.3389/fncel.2019.00330,https://pubmed.ncbi.nlm.nih.gov/31474830/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,34889895,Homozygosity Haplotype and Whole-Exome Sequencing Analysis to Identify Potentially Functional Rare Variants Involved in Multiple Sclerosis among Sardinian Families.,2021,10.3390/cimb43030125,https://pubmed.ncbi.nlm.nih.gov/34889895/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,34946969,Genome-Wide Association Study Candidate Genes on Mammary System-Related Teat-Shape Conformation Traits in Chinese Holstein Cattle.,2021,10.3390/genes12122020,https://pubmed.ncbi.nlm.nih.gov/34946969/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,33649193,Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions.,2021,10.1158/1541-7786.mcr-20-0937,https://pubmed.ncbi.nlm.nih.gov/33649193/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,26069720,Recent progress in the genetics of diabetic microvascular complications.,2015,10.4239/wjd.v6.i5.715,https://pubmed.ncbi.nlm.nih.gov/26069720/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,25646961,Identification of an interaction between VWF rs7965413 and platelet count as a novel risk marker for metabolic syndrome: an extensive search of candidate polymorphisms in a case-control study.,2015,10.1371/journal.pone.0117591,https://pubmed.ncbi.nlm.nih.gov/25646961/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO16,ENSG00000041515,Unsafe,21412220,An intergenic region on chromosome 13q33.3 is associated with the susceptibility to kidney disease in type 1 and 2 diabetes.,2011,10.1038/ki.2011.64,https://pubmed.ncbi.nlm.nih.gov/21412220/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,42572620,Exploring phosphoregulation of MYO3A using quantitative fluorescence image analysis in COS7 cells.,2026,10.17912/micropub.biology.002189,https://pubmed.ncbi.nlm.nih.gov/42572620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,42442274,Multi-omics analyses reveal the regulatory mechanisms of riboflavin to improve meat quality in Pekin ducks.,2026,10.1016/j.psj.2026.107325,https://pubmed.ncbi.nlm.nih.gov/42442274/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,40593742,Myosin-dependent short actin filaments contribute to peripheral widening in developing stereocilia.,2025,10.1038/s41467-025-60976-y,https://pubmed.ncbi.nlm.nih.gov/40593742/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,40100472,Whole exome sequencing diagnosing syndromic and non-syndromic hearing loss with expansion of the phenotypic spectrum related to TMC1 variants.,2025,10.1007/s00431-025-06052-5,https://pubmed.ncbi.nlm.nih.gov/40100472/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,40806634,DNA Methylation in Bladder Cancer: Diagnostic and Therapeutic Perspectives-A Narrative Review.,2025,10.3390/ijms26157507,https://pubmed.ncbi.nlm.nih.gov/40806634/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,39858639,"The Prevalence and Clinical Characteristics of &lt;i&gt;MYO3A&lt;/i&gt;-Associated Hearing Loss in 15,684 Hearing Loss Patients.",2025,10.3390/genes16010092,https://pubmed.ncbi.nlm.nih.gov/39858639/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,38562617,Pathophysiology of human hearing loss associated with variants in myosins.,2024,10.3389/fphys.2024.1374901,https://pubmed.ncbi.nlm.nih.gov/38562617/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,35962067,Selective binding and transport of protocadherin 15 isoforms by stereocilia unconventional myosins in a heterologous expression system.,2022,10.1038/s41598-022-17757-0,https://pubmed.ncbi.nlm.nih.gov/35962067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,38042485,The dynamics of actin protrusions can be controlled by tip-localized myosin motors.,2024,10.1016/j.jbc.2023.105516,https://pubmed.ncbi.nlm.nih.gov/38042485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,39037077,Germline variants in patients diagnosed with pediatric soft tissue sarcoma.,2024,10.2340/1651-226x.2024.40730,https://pubmed.ncbi.nlm.nih.gov/39037077/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,39004380,"Thyroid hormone T4 mitigates traumatic brain injury in mice by dynamically remodeling cell type specific genes, pathways, and networks in hippocampus and frontal cortex.",2024,10.1016/j.bbadis.2024.167344,https://pubmed.ncbi.nlm.nih.gov/39004380/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,38778612,A Mutation in the CACNA1F Gene Found by Whole Exome Sequencing (WES) and &lt;i&gt;In Silico&lt;/i&gt; Analysis in an Iranian Family with Consanguineous Relationships.,2025,10.2174/0118746098307079240507063045,https://pubmed.ncbi.nlm.nih.gov/38778612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,32519820,A novel missense variant in MYO3A is associated with autosomal dominant high-frequency hearing loss in a German family.,2020,10.1002/mgg3.1343,https://pubmed.ncbi.nlm.nih.gov/32519820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,36175575,Identification of novel differentially expressed genes in type 1 diabetes mellitus complications using transcriptomic profiling of UAE patients: a multicenter study.,2022,10.1038/s41598-022-18997-w,https://pubmed.ncbi.nlm.nih.gov/36175575/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,34788109,Deafness mutation in the MYO3A motor domain impairs actin protrusion elongation mechanism.,2022,10.1091/mbc.e21-05-0232,https://pubmed.ncbi.nlm.nih.gov/34788109/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,39004484,Prenatal diagnosis of a de novo 10p12.1p11.23 microdeletion encompassing the WAC gene in a fetus associated with bilateral hydronephrosis and right clubfoot on prenatal ultrasound.,2024,10.1016/j.tjog.2024.05.008,https://pubmed.ncbi.nlm.nih.gov/39004484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,29880844,Characterization of a novel MYO3A missense mutation associated with a dominant form of late onset hearing loss.,2018,10.1038/s41598-018-26818-2,https://pubmed.ncbi.nlm.nih.gov/29880844/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,33718386,Functional Role of Class III Myosins in Hair Cells.,2021,10.3389/fcell.2021.643856,https://pubmed.ncbi.nlm.nih.gov/33718386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,30123247,Knock-In Mice with Myo3a Y137C Mutation Displayed Progressive Hearing Loss and Hair Cell Degeneration in the Inner Ear.,2018,10.1155/2018/4372913,https://pubmed.ncbi.nlm.nih.gov/30123247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,27622050,Macrophages promote matrix protrusive and invasive function of breast cancer cells via MIP-1β dependent upregulation of MYO3A gene in breast cancer cells.,2016,10.1080/2162402x.2016.1196299,https://pubmed.ncbi.nlm.nih.gov/27622050/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,42837869,From single metals to mixtures: uncovering genetic risk factors for metal exposure in disease-free individuals from the EPIC-Spain cohort.,2026,10.1016/j.ijheh.2026.114922,https://pubmed.ncbi.nlm.nih.gov/42837869/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,35049806,Gene-Set Enrichment Analysis for Identifying Genes and Biological Activities Associated with Growth Traits in Dromedaries.,2022,10.3390/ani12020184,https://pubmed.ncbi.nlm.nih.gov/35049806/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3A,ENSG00000095777,Unsafe,20090771,Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis.,2010,10.1038/gene.2009.110,https://pubmed.ncbi.nlm.nih.gov/20090771/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,39297944,MYO3B promotes cancer progression in endometrial cancer by mediating the calcium ion-RhoA/ROCK1 signaling pathway.,2024,10.1007/s00432-024-05940-x,https://pubmed.ncbi.nlm.nih.gov/39297944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,41353195,"Microstructure and transcriptomics reveal rapid light-induced visual plasticity in the non-obligate cave dweller Oreolalax rhodostigmatus (Megophryidae, Anura).",2025,10.1186/s12864-025-12379-y,https://pubmed.ncbi.nlm.nih.gov/41353195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,41104335,Role of biomarker SOCS1 in peritoneal dialysis-associated peritoneal fibrosis and immune infiltration based on machine learning screening.,2025,10.3389/fphar.2025.1646948,https://pubmed.ncbi.nlm.nih.gov/41104335/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,35962067,Selective binding and transport of protocadherin 15 isoforms by stereocilia unconventional myosins in a heterologous expression system.,2022,10.1038/s41598-022-17757-0,https://pubmed.ncbi.nlm.nih.gov/35962067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,37140068,Genetic analysis of probable sleep bruxism and its associations with clinical and behavioral traits.,2023,10.1093/sleep/zsad107,https://pubmed.ncbi.nlm.nih.gov/37140068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,35472719,A Genome-Wide Association Study on Abdominal Adiposity-Related Traits in Adult Korean Men.,2022,10.1159/000524670,https://pubmed.ncbi.nlm.nih.gov/35472719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,33718386,Functional Role of Class III Myosins in Hair Cells.,2021,10.3389/fcell.2021.643856,https://pubmed.ncbi.nlm.nih.gov/33718386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,27582493,Impact of the Motor and Tail Domains of Class III Myosins on Regulating the Formation and Elongation of Actin Protrusions.,2016,10.1074/jbc.m116.733741,https://pubmed.ncbi.nlm.nih.gov/27582493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,37098184,Identification of candidate genes associated with carcass component weights in commercial crossbred pigs through a combined GWAS approach.,2023,10.1093/jas/skad121,https://pubmed.ncbi.nlm.nih.gov/37098184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,31002663,Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons.,2019,10.1371/journal.pbio.3000235,https://pubmed.ncbi.nlm.nih.gov/31002663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,26926603,Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like.,2016,10.1038/ncomms10833,https://pubmed.ncbi.nlm.nih.gov/26926603/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,26754646,Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.,2016,10.1083/jcb.201509017,https://pubmed.ncbi.nlm.nih.gov/26754646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,19332056,Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments.,2009,10.1016/j.exer.2009.03.011,https://pubmed.ncbi.nlm.nih.gov/19332056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,25822849,Invertebrate and vertebrate class III myosins interact with MORN repeat-containing adaptor proteins.,2015,10.1371/journal.pone.0122502,https://pubmed.ncbi.nlm.nih.gov/25822849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,30255769,Joint analysis of genetic and epigenetic data using a conditional autoregressive model.,2018,10.1186/s12863-018-0641-8,https://pubmed.ncbi.nlm.nih.gov/30255769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,12631723,"Myo3A, one of two class III myosin genes expressed in vertebrate retina, is localized to the calycal processes of rod and cone photoreceptors and is expressed in the sacculus.",2003,10.1091/mbc.e02-06-0317,https://pubmed.ncbi.nlm.nih.gov/12631723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,22264607,Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions.,2012,10.1016/j.cub.2011.12.053,https://pubmed.ncbi.nlm.nih.gov/22264607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,11991710,A class III myosin expressed in the retina is a potential candidate for Bardet-Biedl syndrome.,2002,10.1006/geno.2002.6749,https://pubmed.ncbi.nlm.nih.gov/11991710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,26098909,Genome-Wide Association Identifies SLC2A9 and NLN Gene Regions as Associated with Entropion in Domestic Sheep.,2015,10.1371/journal.pone.0128909,https://pubmed.ncbi.nlm.nih.gov/26098909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYO3B,ENSG00000071909,Unsafe,24496092,Genome-wide association study identifies novel loci associated with resistance to bovine tuberculosis.,2014,10.1038/hdy.2013.137,https://pubmed.ncbi.nlm.nih.gov/24496092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,42894947,Neurobehavioral Profiles and Clinical Consequences of MYT1L-Related Neurodevelopmental Disorder: Insights From the Brain Gene Registry.,2026,10.1002/ajmg.a.70321,https://pubmed.ncbi.nlm.nih.gov/42894947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,41907794,A Novel Variant in the MYT1L Gene Shared by Three Individuals with Neuropsychiatric and Neurodevelopmental Manifestations in a Family.,2026,10.1177/02537176261433412,https://pubmed.ncbi.nlm.nih.gov/41907794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,41210245,&lt;i&gt;De novo&lt;/i&gt; missense mutation in &lt;i&gt;MYT1l&lt;/i&gt; leading to autosomal dominant intellectual disability 39 and autism spectrum disorder: a case report.,2025,10.3389/fped.2025.1672911,https://pubmed.ncbi.nlm.nih.gov/41210245/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,40362634,A Positive Feedback DNA-PK/MYT1L-CXCR1-ERK1/2 Proliferative Signaling Loop in Glioblastoma.,2025,10.3390/ijms26094398,https://pubmed.ncbi.nlm.nih.gov/40362634/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,40729938,A survey of hypothalamic phenotypes identifies molecular and behavioral consequences of MYT1L haploinsufficiency in male and female mice.,2025,10.1016/j.yhbeh.2025.105796,https://pubmed.ncbi.nlm.nih.gov/40729938/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,41743545,Infants exposed to maternal type 1 diabetes: intrauterine epigenetic modifications and neurological development.,2026,10.3389/fendo.2026.1759949,https://pubmed.ncbi.nlm.nih.gov/41743545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,40020682,"Autism- and intellectual disability-associated MYT1L mutation alters human cortical interneuron differentiation, maturation, and physiology.",2025,10.1016/j.stemcr.2025.102421,https://pubmed.ncbi.nlm.nih.gov/40020682/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,42465041,Pbx1 and Pbx3 cooperatively regulate intermediate progenitor genesis and corticogenesis in the mouse neocortex.,2026,10.3389/fcell.2026.1809251,https://pubmed.ncbi.nlm.nih.gov/42465041/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,39604385,MYT1L deficiency impairs excitatory neuron trajectory during cortical development.,2024,10.1038/s41467-024-54371-2,https://pubmed.ncbi.nlm.nih.gov/39604385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,41061791,MYT1L promotes autophagy to ameliorate amyloid-β pathology and cognitive deficits in Alzheimer's disease via Notch signaling pathway.,2025,10.1016/j.expneurol.2025.115492,https://pubmed.ncbi.nlm.nih.gov/41061791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,39930023,Lifespan in rodents with MYT1L heterozygous mutation.,2025,10.1038/s41598-025-88462-x,https://pubmed.ncbi.nlm.nih.gov/39930023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,42614171,"Female chronic social defeat stress (&lt;i&gt;fem&lt;/i&gt;CSDS) maps synaptic, bioenergetic and metabolic proteome remodeling in the nucleus accumbens (NAc).",2026,10.3389/fsysb.2026.1904427,https://pubmed.ncbi.nlm.nih.gov/42614171/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,42246686,Relationship Between Central Sensitization and Genetic Polymorphisms-A Case-Control Study in Fibromyalgia.,2026,10.1002/ejp.70308,https://pubmed.ncbi.nlm.nih.gov/42246686/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,40846972,Correction to: Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice.,2025,10.1186/s13229-025-00677-x,https://pubmed.ncbi.nlm.nih.gov/40846972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,39966983,Chromosomal and gonadal sex have differing effects on social motivation in mice.,2025,10.1186/s13293-025-00690-y,https://pubmed.ncbi.nlm.nih.gov/39966983/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,41303563,Altered Co-Expression Patterns of Mitochondrial NADH-Dehydrogenase Genes in the Prefrontal Cortex of Rodent ADHD Models.,2025,10.3390/ijms262211079,https://pubmed.ncbi.nlm.nih.gov/41303563/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,41539561,Deregulated translation of the transcription factor Myt3 predisposes islet β cells to dysfunction under obesity-induced metabolic stress.,2026,10.1016/j.jbc.2026.111164,https://pubmed.ncbi.nlm.nih.gov/41539561/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,41004595,KMT2D temporally activates neuronal transcriptional factor genes to mediate cerebellar granule cell differentiation.,2025,10.1126/sciadv.adu7174,https://pubmed.ncbi.nlm.nih.gov/41004595/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,42482093,Eating behaviour phenotype in the MYT1L-related neurodevelopmental disorder: a deep phenotyping study using standardized questionnaires.,2026,10.1186/s13023-026-04497-x,https://pubmed.ncbi.nlm.nih.gov/42482093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,41026459,Elucidate biomarkers and the molecular pathways associated with genetic variants that contribute to the etiology of Parkinson's disease.,2025,10.1007/s13760-025-02897-7,https://pubmed.ncbi.nlm.nih.gov/41026459/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,42406628,Structural insights into the binding of CX-5461 and MTR-106 to G-quadruplex DNA.,2026,10.1093/nar/gkag667,https://pubmed.ncbi.nlm.nih.gov/42406628/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,41751972,"Inflammation and Oxidative-Stress Pathways Are Associated with Idiopathic Sudden Hearing Loss: A Genome-Wide Association Study in 15,494 Japanese Individuals.",2026,10.3390/ijms27041836,https://pubmed.ncbi.nlm.nih.gov/41751972/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,35538503,Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice.,2022,10.1186/s13229-022-00497-3,https://pubmed.ncbi.nlm.nih.gov/35538503/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,37464955,Organic-Platinum Hybrids for Covalent Binding of G-Quadruplexes: Structural Basis and Application to Cancer Immunotherapy.,2023,10.1002/anie.202305645,https://pubmed.ncbi.nlm.nih.gov/37464955/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,37232730,Overexpression of OLIG2 and MYT1L Transcription Factors Enhance the Differentiation Potential of Human Mesenchymal Stem Cells into Oligodendrocytes.,2023,10.3390/cimb45050261,https://pubmed.ncbi.nlm.nih.gov/37232730/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,34614421,A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation.,2021,10.1016/j.neuron.2021.09.009,https://pubmed.ncbi.nlm.nih.gov/34614421/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,38409093,Transcriptomic effects of paternal cocaine-seeking on the reward circuitry of male offspring.,2024,10.1038/s41398-024-02839-6,https://pubmed.ncbi.nlm.nih.gov/38409093/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,35468096,Effective biomarkers and therapeutic targets of nerve-immunity interaction in the treatment of depression: an integrated investigation of the miRNA-mRNA regulatory networks.,2022,10.18632/aging.204030,https://pubmed.ncbi.nlm.nih.gov/35468096/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,35409080,Transcription Factors with Targeting Potential in Gliomas.,2022,10.3390/ijms23073720,https://pubmed.ncbi.nlm.nih.gov/35409080/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,35983069,Sexually dimorphic transcriptional programs of early-phase response in regenerating peripheral nerves.,2022,10.3389/fnmol.2022.958568,https://pubmed.ncbi.nlm.nih.gov/35983069/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,35014204,Designer Extracellular Vesicles Modulate Pro-Neuronal Cell Responses and Improve Intracranial Retention.,2022,10.1002/adhm.202100805,https://pubmed.ncbi.nlm.nih.gov/35014204/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,33941792,A web-based survey on various symptoms of computer vision syndrome and the genetic understanding based on a multi-trait genome-wide association study.,2021,10.1038/s41598-021-88827-y,https://pubmed.ncbi.nlm.nih.gov/33941792/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,26711960,Deterministic transfection drives efficient nonviral reprogramming and uncovers reprogramming barriers.,2016,10.1016/j.nano.2015.11.015,https://pubmed.ncbi.nlm.nih.gov/26711960/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
MYT1L,ENSG00000186487,Unsafe,31386623,A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes.,2019,10.7554/elife.46703,https://pubmed.ncbi.nlm.nih.gov/31386623/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
N4BP2,ENSG00000078177,Unsafe,41379955,Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes.,2025,10.1126/science.ado0977,https://pubmed.ncbi.nlm.nih.gov/41379955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
N4BP2,ENSG00000078177,Unsafe,39170496,PMEL is a predictive biomarker for mTORC1 inhibitor treatment of renal angiomyolipoma in tuberous sclerosis complex patients.,2024,10.1016/j.heliyon.2024.e34937,https://pubmed.ncbi.nlm.nih.gov/39170496/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
N4BP2,ENSG00000078177,Unsafe,39878408,Transcriptome-Wide Association Study Identified Novel Blood Tissue Gene Biomarkers for Prostate Cancer Risk.,2025,10.1002/pros.24859,https://pubmed.ncbi.nlm.nih.gov/39878408/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
N4BP2,ENSG00000078177,Unsafe,39413985,Identifying prognostic hub genes and key pathways in pediatric adrenocortical tumors through RNA sequencing and Co-expression analysis.,2024,10.1016/j.mce.2024.112383,https://pubmed.ncbi.nlm.nih.gov/39413985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
N4BP2,ENSG00000078177,Unsafe,38339272,Surface Proteome of Extracellular Vesicles and Correlation Analysis Reveal Breast Cancer Biomarkers.,2024,10.3390/cancers16030520,https://pubmed.ncbi.nlm.nih.gov/38339272/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
N4BP2,ENSG00000078177,Unsafe,39350025,"A large structural variant collection in Holstein cattle and associated database for variant discovery, characterization, and application.",2024,10.1186/s12864-024-10812-2,https://pubmed.ncbi.nlm.nih.gov/39350025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
N4BP2,ENSG00000078177,Unsafe,24619003,Identification of genes with consistent methylation levels across different human tissues.,2014,10.1038/srep04351,https://pubmed.ncbi.nlm.nih.gov/24619003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
N4BP2,ENSG00000078177,Unsafe,24702795,Analysing the relationship between lncRNA and protein-coding gene and the role of lncRNA as ceRNA in pulmonary fibrosis.,2014,10.1111/jcmm.12243,https://pubmed.ncbi.nlm.nih.gov/24702795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
N4BP2,ENSG00000078177,Unsafe,17626640,Haplotype of gene Nedd4 binding protein 2 associated with sporadic nasopharyngeal carcinoma in the Southern Chinese population.,2007,10.1186/1479-5876-5-36,https://pubmed.ncbi.nlm.nih.gov/17626640/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
N4BP2,ENSG00000078177,Unsafe,28425186,Association studies of low-frequency coding variants in nonsyndromic cleft lip with or without cleft palate.,2017,10.1002/ajmg.a.38210,https://pubmed.ncbi.nlm.nih.gov/28425186/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
N4BP2,ENSG00000078177,Unsafe,26850007,Genomic alterations of the JAK2 and PDL loci occur in a broad spectrum of lymphoid malignancies.,2016,10.1002/gcc.22345,https://pubmed.ncbi.nlm.nih.gov/26850007/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
N4BP2,ENSG00000078177,Unsafe,12730195,Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination.,2003,10.1074/jbc.m303518200,https://pubmed.ncbi.nlm.nih.gov/12730195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,39575888,NAALADL2-AS2 functions as a competing endogenous RNA to regulate apoptosis and drug resistance in DLBCL.,2024,10.1080/15384047.2024.2432690,https://pubmed.ncbi.nlm.nih.gov/39575888/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,42804823,High‑resolution recombination landscape in Iranian native chicken ecotypes: Elevated hotspot density and candidate genes for heat and drought adaptation.,2026,10.1016/j.psj.2026.107789,https://pubmed.ncbi.nlm.nih.gov/42804823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,36548180,The Androgen Regulated lncRNA NAALADL2-AS2 Promotes Tumor Cell Survival in Prostate Cancer.,2022,10.3390/ncrna8060081,https://pubmed.ncbi.nlm.nih.gov/36548180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,39501294,Deep joint learning diagnosis of Alzheimer's disease based on multimodal feature fusion.,2024,10.1186/s13040-024-00395-9,https://pubmed.ncbi.nlm.nih.gov/39501294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,40500699,Genomic analysis association of tolerance to heat stress in subtropical Egyptian goats Raised in hot dry environment.,2025,10.1186/s12864-025-11748-x,https://pubmed.ncbi.nlm.nih.gov/40500699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,38755281,Optical genome mapping unveils hidden structural variants in neurodevelopmental disorders.,2024,10.1038/s41598-024-62009-y,https://pubmed.ncbi.nlm.nih.gov/38755281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,39595990,Insights into Adaption and Growth Evolution: Genome-Wide Copy Number Variation Analysis in Chinese Hainan Yellow Cattle Using Whole-Genome Re-Sequencing Data.,2024,10.3390/ijms252211919,https://pubmed.ncbi.nlm.nih.gov/39595990/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,32796921,Genetic alterations in the 3q26.31-32 locus confer an aggressive prostate cancer phenotype.,2020,10.1038/s42003-020-01175-x,https://pubmed.ncbi.nlm.nih.gov/32796921/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,34944897,RNA Biomarkers as a Response Measure for Survival in Patients with Metastatic Castration-Resistant Prostate Cancer.,2021,10.3390/cancers13246279,https://pubmed.ncbi.nlm.nih.gov/34944897/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,37232821,Immune-Related Long Non-Coding RNA Signatures for Tongue Squamous Cell Carcinoma.,2023,10.3390/curroncol30050363,https://pubmed.ncbi.nlm.nih.gov/37232821/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,33980983,The oncological relevance of fragile sites in cancer.,2021,10.1038/s42003-021-02020-5,https://pubmed.ncbi.nlm.nih.gov/33980983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,35345457,Multi-omics &amp; pathway analysis identify potential roles for tumor N-acetyl aspartate accumulation in murine models of castration-resistant prostate cancer.,2022,10.1016/j.isci.2022.104056,https://pubmed.ncbi.nlm.nih.gov/35345457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,32408351,Prognostic Value of Novel Liquid Biomarkers in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Enzalutamide: A Prospective Observational Study.,2020,10.1093/clinchem/hvaa095,https://pubmed.ncbi.nlm.nih.gov/32408351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,28045058,Identification of genetic susceptibility loci for intestinal Behçet's disease.,2017,10.1038/srep39850,https://pubmed.ncbi.nlm.nih.gov/28045058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,35729510,Assessing genomic diversity and signatures of selection in Pinan cattle using whole-genome sequencing data.,2022,10.1186/s12864-022-08645-y,https://pubmed.ncbi.nlm.nih.gov/35729510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,24240687,N-acetyl-L-aspartyl-L-glutamate peptidase-like 2 is overexpressed in cancer and promotes a pro-migratory and pro-metastatic phenotype.,2014,10.1038/onc.2013.464,https://pubmed.ncbi.nlm.nih.gov/24240687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,27409348,Identification and validation of regulatory SNPs that modulate transcription factor chromatin binding and gene expression in prostate cancer.,2016,10.18632/oncotarget.10520,https://pubmed.ncbi.nlm.nih.gov/27409348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,28898263,Genome-wide analysis of parent-of-origin interaction effects with environmental exposure (PoOxE): An application to European and Asian cleft palate trios.,2017,10.1371/journal.pone.0184358,https://pubmed.ncbi.nlm.nih.gov/28898263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,28145423,Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers.,2017,10.1038/ejhg.2016.203,https://pubmed.ncbi.nlm.nih.gov/28145423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,29362828,Genetic differences in C57BL/6 mouse substrains affect kidney crystal deposition.,2018,10.1007/s00240-018-1040-3,https://pubmed.ncbi.nlm.nih.gov/29362828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,25939597,Two susceptibility loci identified for prostate cancer aggressiveness.,2015,10.1038/ncomms7889,https://pubmed.ncbi.nlm.nih.gov/25939597/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,27629806,Genomic findings in patients with clinical suspicion of 22q11.2 deletion syndrome.,2017,10.1007/s13353-016-0366-1,https://pubmed.ncbi.nlm.nih.gov/27629806/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NAALADL2,ENSG00000177694,Unsafe,19132087,A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease.,2009,10.1371/journal.pgen.1000319,https://pubmed.ncbi.nlm.nih.gov/19132087/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NACA2,ENSG00000253506,Unsafe,22678995,Studies of TBX4 and chromosome 17q23.1q23.2: an uncommon cause of nonsyndromic clubfoot.,2012,10.1002/ajmg.a.35418,https://pubmed.ncbi.nlm.nih.gov/22678995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NACA2,ENSG00000253506,Unsafe,9734614,NCX1 Na/Ca exchanger inhibition by antisense oligonucleotides in mouse distal convoluted tubule cells.,1998,10.1046/j.1523-1755.1998.00056.x,https://pubmed.ncbi.nlm.nih.gov/9734614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NACA2,ENSG00000253506,Unsafe,7694482,Na/Ca exchanger isoforms expressed in kidney.,1993,10.1152/ajprenal.1993.265.4.f598,https://pubmed.ncbi.nlm.nih.gov/7694482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NACA2,ENSG00000253506,Unsafe,16201836,Emergence of young human genes after a burst of retroposition in primates.,2005,10.1371/journal.pbio.0030357,https://pubmed.ncbi.nlm.nih.gov/16201836/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NBPF6,ENSG00000186086,Unsafe,28329217,Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life Family Study.,2017,10.1093/gerona/glx011,https://pubmed.ncbi.nlm.nih.gov/28329217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,42490819,Integrated Bioinformatics Analysis Identifies NCAPG2 as an Immune-Related Prognostic Biomarker in Breast Cancer.,2026,10.14740/wjon2768,https://pubmed.ncbi.nlm.nih.gov/42490819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,41907601,Bioinformatics and experimental analysis revealed the cancer-promoting role of NCAPG2 in epithelial ovarian cancer.,2026,10.3389/fonc.2026.1574236,https://pubmed.ncbi.nlm.nih.gov/41907601/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,41894088,USP52 impedes malignant progression and cell stemness in prostate cancer by deubiquitinating RBM5 to down-regulate NCAPG2.,2026,10.1007/s11010-026-05522-0,https://pubmed.ncbi.nlm.nih.gov/41894088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,40447854,NCAPG2 is a diagnostic biomarker associated with immune infiltration in cholangiocarcinoma.,2025,10.1007/s12672-025-02809-4,https://pubmed.ncbi.nlm.nih.gov/40447854/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,40552444,RPL35A Downregulation Suppresses Hepatocellular Carcinoma Cell Proliferation via NCAPG2 Inactivation.,2025,10.1002/cam4.70985,https://pubmed.ncbi.nlm.nih.gov/40552444/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,41139451,[PDZ-binding kinase as a prognostic biomarker for pancreatic cancer: a pan-cancer analysis and validation in pancreatic adenocarcinoma cells].,2025,10.12122/j.issn.1673-4254.2025.10.17,https://pubmed.ncbi.nlm.nih.gov/41139451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,42519679,Situs Inversus Totalis and Severe Early-Onset Developmental Epileptic Encephalopathy in a Child With a Homozygous CFAP52 Mutation: A Case Report.,2026,10.1002/ccr3.73165,https://pubmed.ncbi.nlm.nih.gov/42519679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,40375564,"NCAPG2 promotes the proliferation, metastasis and resistance to nab-paclitaxel in gastric adenocarcinoma cells.",2026,10.1080/1120009x.2025.2498230,https://pubmed.ncbi.nlm.nih.gov/40375564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,38701261,MYC and NCAPG2 as molecular targets of colorectal cancer and gastric cancer in nursing.,2024,10.1097/md.0000000000038029,https://pubmed.ncbi.nlm.nih.gov/38701261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,37501987,Pan-cancer analysis of the immune aspects and prognostic value of NCAPG2.,2023,10.1016/j.heliyon.2023.e18051,https://pubmed.ncbi.nlm.nih.gov/37501987/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,38166947,NCAPG2 promotes prostate cancer malignancy and stemness via STAT3/c-MYC signaling.,2024,10.1186/s12967-023-04834-9,https://pubmed.ncbi.nlm.nih.gov/38166947/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,42436575,Host genetic architecture and gut microbiota cooperatively regulate early growth in goats.,2026,10.1186/s42523-026-00597-y,https://pubmed.ncbi.nlm.nih.gov/42436575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,38637125,Mining and exploration of rehabilitation nursing targets for colorectal cancer.,2024,10.18632/aging.205739,https://pubmed.ncbi.nlm.nih.gov/38637125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,40134128,SMC2 and Condensin II Subunits Are Essential for the Development of Hematopoietic Stem and Progenitor Cells in Zebrafish.,2025,10.1002/jcp.70023,https://pubmed.ncbi.nlm.nih.gov/40134128/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,36776838,NCAPG2 could be an immunological and prognostic biomarker: From pan-cancer analysis to pancreatic cancer validation.,2023,10.3389/fimmu.2023.1097403,https://pubmed.ncbi.nlm.nih.gov/36776838/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,37248471,Circular RNA circ0001955 promotes cervical cancer tumorigenesis and metastasis via the miR-188-3p/NCAPG2 axis.,2023,10.1186/s12967-023-04194-4,https://pubmed.ncbi.nlm.nih.gov/37248471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,35898895,NCAPG2 Is a Novel Prognostic Biomarker and Promotes Cancer Stem Cell Maintenance in Low-Grade Glioma.,2022,10.3389/fonc.2022.918606,https://pubmed.ncbi.nlm.nih.gov/35898895/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,39045040,Unveiling the Significance of NCAP Family Genes in Adrenocortical Carcinoma and Adenoma Pathogenesis: A Molecular Bioinformatics Exploration.,2024,10.1177/11769351241262211,https://pubmed.ncbi.nlm.nih.gov/39045040/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,35664767,LncRNA-AL035458.2/hsa-miR-181a-5p Axis-Mediated High Expression of NCAPG2 Correlates With Tumor Immune Infiltration and Non-Small Cell Lung Cancer Progression.,2022,10.3389/fonc.2022.910437,https://pubmed.ncbi.nlm.nih.gov/35664767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,37544634,"The mRNA stability of NCAPG2, a novel contributor to breast invasive carcinoma, is enhanced by the RNA-binding protein PCBP2.",2023,10.1016/j.cellsig.2023.110844,https://pubmed.ncbi.nlm.nih.gov/37544634/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,39472236,Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation.,2024,10.1016/j.ebiom.2024.105411,https://pubmed.ncbi.nlm.nih.gov/39472236/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,38883382,RACGAP1 knockdown synergizes and enhances the effects of chemotherapeutics on ovarian cancer.,2024,10.62347/qnzu1402,https://pubmed.ncbi.nlm.nih.gov/38883382/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,36059662,LncRNA-AC009948.5 promotes invasion and metastasis of lung adenocarcinoma by binding to miR-186-5p.,2022,10.3389/fonc.2022.949951,https://pubmed.ncbi.nlm.nih.gov/36059662/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,36138066,Analyzing integrated network of methylation and gene expression profiles in lung squamous cell carcinoma.,2022,10.1038/s41598-022-20232-5,https://pubmed.ncbi.nlm.nih.gov/36138066/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,38001857,"Associations between the New DNA-Methylation-Based Telomere Length Estimator, the Mediterranean Diet and Genetics in a Spanish Population at High Cardiovascular Risk.",2023,10.3390/antiox12112004,https://pubmed.ncbi.nlm.nih.gov/38001857/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPG2,ENSG00000146918,Unsafe,17611626,Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression.,2007,10.1371/journal.pone.0000594,https://pubmed.ncbi.nlm.nih.gov/17611626/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,42703414,Non-structural maintenance of chromosome condensin I complex subunit H knockdown suppresses malignant progression of esophageal squamous cell carcinoma via the Wnt/β-catenin signaling pathway.,2026,10.21037/jgo-2025-1-1060,https://pubmed.ncbi.nlm.nih.gov/42703414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,42325921,Comprehensive bioinformatics analysis of NCAPH expression and its clinical importance in endometrial cancer.,2026,10.3892/ol.2026.15696,https://pubmed.ncbi.nlm.nih.gov/42325921/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,41210692,"NCAPH as a potential prognostic signaling biomarker regulating low-grade glioma cell proliferation, migration, invasion, immune microenvironment, and drug sensitivity.",2025,10.7150/jca.115870,https://pubmed.ncbi.nlm.nih.gov/41210692/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,42137875,Identification of shared biomarkers in obesity and non-alcoholic fatty liver disease: a comprehensive analysis of Mendelian randomization and transcriptomic data.,2026,10.3389/fnut.2026.1780686,https://pubmed.ncbi.nlm.nih.gov/42137875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,40999529,NCAPH-YAP1 interaction promotes breast cancer stemness and tumor progression.,2025,10.1186/s13287-025-04648-0,https://pubmed.ncbi.nlm.nih.gov/40999529/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,40949445,Non-SMC condensin I complex subunit H promotes cell proliferation and inhibits cell apoptosis of clear cell renal cell carcinoma by activating the PI3K/AKT pathway.,2025,10.21037/tau-2025-197,https://pubmed.ncbi.nlm.nih.gov/40949445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,42496426,Pancreatic Hyperenzymemia in Inflammatory Bowel Disease: Clinical Characterization and Outcomes from the European PANDORA Registry.,2026,10.3390/pathophysiology33030044,https://pubmed.ncbi.nlm.nih.gov/42496426/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,40699282,MiR-1976 affects lung squamous cell carcinoma development by targeting NCAPH.,2026,10.1007/s13353-025-00990-4,https://pubmed.ncbi.nlm.nih.gov/40699282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,42072775,Integrative Bioinformatic Analysis Identifies Key Genes Driving Breast Cancer Brain Metastasis.,2026,10.3390/diagnostics16081149,https://pubmed.ncbi.nlm.nih.gov/42072775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,42582038,Heterogeneity and molecular typing characteristics of mast cells in rheumatoid arthritis.,2026,10.3389/fmolb.2026.1898923,https://pubmed.ncbi.nlm.nih.gov/42582038/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,40627684,The MDM2-p53 axis regulates norrin/frizzled4 signaling and blood-CNS barrier function.,2025,10.1126/scisignal.adt0983,https://pubmed.ncbi.nlm.nih.gov/40627684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,42589442,MicroRNA Signatures of Fulvestrant-Treated Luminal Breast Cancer Cells: Identification of Therapeutic Targets Regulated by &lt;i&gt;miR-374b-5p&lt;/i&gt;.,2026,10.3390/ijms27156787,https://pubmed.ncbi.nlm.nih.gov/42589442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,39991770,NCAPH Promotes the Proliferation of Prostate Cancer Cells Via Modulating the E2F1 Mediated PI3K/AKT/mTOR Axis.,2025,10.7150/ijms.103444,https://pubmed.ncbi.nlm.nih.gov/39991770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,40259316,NCAPH promotes glucose metabolism reprogramming and cell stemness in ovarian cancer cells through the MEK/ERK/PD-L1 pathway.,2025,10.1186/s13048-025-01659-6,https://pubmed.ncbi.nlm.nih.gov/40259316/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,38587786,NCAPH serves as a prognostic factor and promotes the tumor progression in glioma through PI3K/AKT signaling pathway.,2025,10.1007/s11010-024-04976-4,https://pubmed.ncbi.nlm.nih.gov/38587786/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,38755247,MiR-1976/NCAPH/P65 axis inhibits the malignant phenotypes of lung adenocarcinoma.,2024,10.1038/s41598-024-61261-6,https://pubmed.ncbi.nlm.nih.gov/38755247/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,39620395,circEIF3I Promotes Colorectal Cancer Metastasis by Regulating the miR-328-3p/NCAPH Axis.,2025,10.1002/mc.23860,https://pubmed.ncbi.nlm.nih.gov/39620395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,39276521,ZCCHC3 and Efp coordinately contribute to the pathophysiology of triple-negative breast cancer by modulating NCAPH.,2024,10.1016/j.bbrc.2024.150663,https://pubmed.ncbi.nlm.nih.gov/39276521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,39103348,"NCAPH, ubiquitinated by TRIM21, promotes cell proliferation by inhibiting autophagy of cervical cancer through AKT/mTOR dependent signaling.",2024,10.1038/s41419-024-06932-y,https://pubmed.ncbi.nlm.nih.gov/39103348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,39543244,Enhancing risk stratification models in localized prostate cancer by novel validated tissue biomarkers.,2025,10.1038/s41391-024-00918-9,https://pubmed.ncbi.nlm.nih.gov/39543244/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,36642844,Non-SMC condensin I complex subunit H participates in anti-programmed cell death-1 resistance of clear cell renal cell carcinomas.,2023,10.1111/cpr.13400,https://pubmed.ncbi.nlm.nih.gov/36642844/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,41064634,Integrated analysis and experimental validation of E2F2 as a potential prognostic biomarker and its oncogenic roles in serous ovarian cancer.,2025,10.3389/fmolb.2025.1661558,https://pubmed.ncbi.nlm.nih.gov/41064634/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,40792151,Identification and validation of hub genes for kidney renal clear cell carcinoma treated with metformin and everolimus combination therapy.,2025,10.21037/tcr-2025-277,https://pubmed.ncbi.nlm.nih.gov/40792151/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,35688915,NCAPH is a prognostic biomarker and associated with immune infiltrates in lung adenocarcinoma.,2022,10.1038/s41598-022-12862-6,https://pubmed.ncbi.nlm.nih.gov/35688915/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,39018801,Investigating the effect of ligand structure on the anticancer properties of several new Co(II) complexes of vitaminB3-based phosphoramides.,2024,10.1016/j.bioorg.2024.107634,https://pubmed.ncbi.nlm.nih.gov/39018801/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,38863714,Integrated bioinformatics combined with machine learning to analyze shared biomarkers and pathways in psoriasis and cervical squamous cell carcinoma.,2024,10.3389/fimmu.2024.1351908,https://pubmed.ncbi.nlm.nih.gov/38863714/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,38726276,High glucose-induced NCAPD2 upregulation promotes malignant phenotypes and regulates EMT via the Wnt/β-catenin signaling pathway in HCC.,2024,10.62347/hynz9211,https://pubmed.ncbi.nlm.nih.gov/38726276/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,38526604,Bioinformatics-based screening and analysis of the key genes involved in the influence of antiangiogenesis on myeloid-derived suppressor cells and their effects on the immune microenvironment.,2024,10.1007/s12032-024-02357-x,https://pubmed.ncbi.nlm.nih.gov/38526604/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,39239040,Esophageal chemical burns as a risk factor for esophageal malignancies: in-silico analyses - experimental research.,2024,10.1097/ms9.0000000000002317,https://pubmed.ncbi.nlm.nih.gov/39239040/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,38329418,"Identification of renal ischemia reperfusion injury-characteristic genes, pathways and immunological micro-environment features through bioinformatics approaches.",2024,10.18632/aging.205471,https://pubmed.ncbi.nlm.nih.gov/38329418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,36741311,YAP-mediated mechanotransduction in urinary bladder remodeling: Based on RNA-seq and CUT&Tag.,2023,10.3389/fgene.2023.1106927,https://pubmed.ncbi.nlm.nih.gov/36741311/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCAPH,ENSG00000121152,Unsafe,11694586,Cell cycle-dependent expression and nucleolar localization of hCAP-H.,2001,10.1091/mbc.12.11.3527,https://pubmed.ncbi.nlm.nih.gov/11694586/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,42904279,Pulmonary innate immune remodeling in &lt;i&gt;Pneumocystis&lt;/i&gt; pneumonia with adaptive immunodeficiency.,2026,10.1097/id9.0000000000000216,https://pubmed.ncbi.nlm.nih.gov/42904279/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,36628881,"Immune infiltration patterns and identification of new diagnostic biomarkers GDF10, NCKAP5, and RTKN2 in non-small cell lung cancer.",2023,10.1016/j.tranon.2023.101618,https://pubmed.ncbi.nlm.nih.gov/36628881/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,40004524,Maternal and Parent-of-Origin Gene-Environment Effects on the Etiology of Orofacial Clefting.,2025,10.3390/genes16020195,https://pubmed.ncbi.nlm.nih.gov/40004524/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,41530715,Redefining social support: a scoping review of the effects of digital technologies on the social support of older workers.,2026,10.1186/s12889-025-26155-w,https://pubmed.ncbi.nlm.nih.gov/41530715/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,41074104,Saliva as a potential and non-invasive approach to identify upregulated genes associated with comorbidities of T1DM: a brief report.,2025,10.1186/s40001-025-03105-1,https://pubmed.ncbi.nlm.nih.gov/41074104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,38480935,Single-cell RNA sequencing analysis of vestibular schwannoma reveals functionally distinct macrophage subsets.,2024,10.1038/s41416-024-02646-2,https://pubmed.ncbi.nlm.nih.gov/38480935/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,39596218,Radial Data Visualization-Based Step-by-Step Eliminative Algorithm to Predict Colorectal Cancer Patients' Response to FOLFOX Therapy.,2024,10.3390/ijms252212149,https://pubmed.ncbi.nlm.nih.gov/39596218/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,39460878,Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA.,2024,10.1186/s41181-024-00304-9,https://pubmed.ncbi.nlm.nih.gov/39460878/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,41253363,The Impact of Digital Technology on the Physical Health of Older Workers: Scoping Review.,2025,10.2196/78406,https://pubmed.ncbi.nlm.nih.gov/41253363/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,39034460,Genome-wide selection reveals candidate genes associated with multiple teats in Hu sheep.,2024,10.1080/10495398.2024.2380766,https://pubmed.ncbi.nlm.nih.gov/39034460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,39067134,A susceptibility gene signature for ERBB2-driven mammary tumour development and metastasis in collaborative cross mice.,2024,10.1016/j.ebiom.2024.105260,https://pubmed.ncbi.nlm.nih.gov/39067134/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,38840048,Whole-genome sequencing reveals genomic diversity and selection signatures in Xia'nan cattle.,2024,10.1186/s12864-024-10463-3,https://pubmed.ncbi.nlm.nih.gov/38840048/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,38233755,Whole-genome resequencing of major populations revealed domestication-related genes in yaks.,2024,10.1186/s12864-024-09993-7,https://pubmed.ncbi.nlm.nih.gov/38233755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,38965845,[Single-cell transcriptomic sequencing coupled with Mendelian randomization analysis elucidates the pivotal role of CTSC in chronic rhinosinusitis].,2024,10.3760/cma.j.cn115330-20231211-00285,https://pubmed.ncbi.nlm.nih.gov/38965845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,38949516,Genome-wide comparative analyses highlight selection signatures underlying saline adaptation in Chilika buffalo.,2024,10.1152/physiolgenomics.00028.2024,https://pubmed.ncbi.nlm.nih.gov/38949516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,31010979,Genome-wide DNA methylation pattern in a mouse model reveals two novel genes associated with Staphylococcus aureus mastitis.,2020,10.5713/ajas.18.0858,https://pubmed.ncbi.nlm.nih.gov/31010979/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,30698341,Job characteristics as risk factors for early retirement due to ill health: The Korean Longitudinal Study of Aging (2006-2014).,2019,10.1002/1348-9585.12014,https://pubmed.ncbi.nlm.nih.gov/30698341/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,38606212,"PRESS (Propofol, Remifentanil, Electricity/EEG, Setup and Setting) to Start: Introducing a Total Intravenous Anaesthesia Checklist at a Large Teaching Hospital.",2024,10.7759/cureus.56026,https://pubmed.ncbi.nlm.nih.gov/38606212/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,34433909,Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients.,2021,10.1038/s41388-021-01998-w,https://pubmed.ncbi.nlm.nih.gov/34433909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,38352277,Genetic Alterations in Invasive Breast Carcinoma with a Glycogen-Rich Clear Cell Pattern: A Case Report.,2021,10.1159/000514978,https://pubmed.ncbi.nlm.nih.gov/38352277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,39325529,The Impact of Digital Technology on the Physical Health of Older Workers: Protocol for a Scoping Review.,2024,10.2196/59900,https://pubmed.ncbi.nlm.nih.gov/39325529/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,27300296,Genome-Wide Association Study between Single Nucleotide Polymorphisms and Flight Speed in Nellore Cattle.,2016,10.1371/journal.pone.0156956,https://pubmed.ncbi.nlm.nih.gov/27300296/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NCKAP5,ENSG00000176771,Unsafe,23646285,Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia.,2013,10.7717/peerj.66,https://pubmed.ncbi.nlm.nih.gov/23646285/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,42064080,Disulfidptosis-related genes define a prognostic signature and novel therapeutic targets in Ewing's sarcoma through transcriptomic analysis and experimental validation.,2026,10.3389/fimmu.2026.1722729,https://pubmed.ncbi.nlm.nih.gov/42064080/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,39877656,"NDUFA11 may be the disulfidptosis-related biomarker of ischemic stroke based on integrated bioinformatics, clinical samples, and experimental analyses.",2024,10.3389/fnins.2024.1505493,https://pubmed.ncbi.nlm.nih.gov/39877656/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,41456051,"Integrative network toxicology, transcriptomic, and molecular docking approaches to elucidate the toxicity and mechanisms of bisphenol A in stroke.",2025,10.1186/s40360-025-01076-x,https://pubmed.ncbi.nlm.nih.gov/41456051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,41236076,"Mechanisms of metformin in alleviating neurological deficits in stroke patients: Involving Ndufa11-mediated mitochondrial protection, enhanced neuronal electrophysiology, and inhibition of disulfidptosis.",2025,10.1016/j.brainresbull.2025.111606,https://pubmed.ncbi.nlm.nih.gov/41236076/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,41003892,Disulfidptosis OXSM serves as a potential prognostic biomarker and correlates with immune infiltrates in glioma.,2025,10.1007/s12672-025-03491-2,https://pubmed.ncbi.nlm.nih.gov/41003892/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,42121777,Stage-Specific Transcriptomic Analysis Reveals Molecular Basis of Ovarian Sterility in Triploid Turbot (&lt;i&gt;Scophthalmus maximus&lt;/i&gt;).,2026,10.3390/ani16091357,https://pubmed.ncbi.nlm.nih.gov/42121777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,40305445,Identification of a disulfidptosis-related genes signature for diagnostic and immune infiltration characteristics in cervical cancer.,2025,10.1371/journal.pone.0322387,https://pubmed.ncbi.nlm.nih.gov/40305445/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,42370567,Prognostic characteristics of disulfidptosis-related genes across cancers and their potential implications in osteosarcoma.,2026,10.1177/00368504261464856,https://pubmed.ncbi.nlm.nih.gov/42370567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,39103773,Analysis of the prognostic value of mitochondria-related genes in patients with acute myocardial infarction.,2024,10.1186/s12872-024-04051-2,https://pubmed.ncbi.nlm.nih.gov/39103773/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,41591656,Machine learning identifies disulfidptosis-related gene signature for pancreatic cancer prognosis and immune infiltration.,2026,10.1007/s12672-026-04463-w,https://pubmed.ncbi.nlm.nih.gov/41591656/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,39805370,Identifying disulfidptosis-related biomarkers in epilepsy based on integrated bioinformatics and experimental analyses.,2025,10.1016/j.nbd.2025.106789,https://pubmed.ncbi.nlm.nih.gov/39805370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,41364140,Mitochondrial energy metabolism genes as prognostic biomarkers in clear cell renal cell carcinoma via single-cell and bulk RNA sequencing analyses.,2025,10.1007/s12672-025-04224-1,https://pubmed.ncbi.nlm.nih.gov/41364140/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,41091262,Identification of an E2Fs-based gene signature for predicting prognosis and therapeutic response in colorectal cancer.,2025,10.1007/s12672-025-02615-y,https://pubmed.ncbi.nlm.nih.gov/41091262/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,41246257,Molecular subtypes and prognostic signature rooted in disulfidptosis highlight tumor microenvironment in lung adenocarcinoma.,2025,10.21147/j.issn.1000-9604.2025.05.11,https://pubmed.ncbi.nlm.nih.gov/41246257/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,42201472,Mitochondrial-Inflammatory Axis Dysregulation Triggers Disulfidptosis and the Multifaceted Protective Mechanism of Bisphenol A Following Spinal Cord Injury.,2026,10.1007/s12035-026-05953-2,https://pubmed.ncbi.nlm.nih.gov/42201472/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,38863903,Identification of Key Disulfidptosis-Related Genes and Their Association with Gene Expression Subtypes in Crohn's Disease.,2024,10.2147/jir.s458951,https://pubmed.ncbi.nlm.nih.gov/38863903/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,39945255,Prediction of the Prognosis and Treatment Responses Based on the Characteristics of Disulfidptosis-Related Genes in Patients with Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma,2026,10.2174/0118715303374396250129111340,https://pubmed.ncbi.nlm.nih.gov/39945255/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,39561568,Autoantibodies against a subunit of mitochondrial respiratory chain complex I in inclusion body myositis.,2024,10.1016/j.jaut.2024.103332,https://pubmed.ncbi.nlm.nih.gov/39561568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,41896730,Genetic analysis of cold tolerance and high-altitude adaptation in Gannan indigenous Tibetan sheep through genome-wide scans.,2026,10.1186/s12864-026-12722-x,https://pubmed.ncbi.nlm.nih.gov/41896730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,41104785,Proteomic profiling of bone tissue reveals distinct pathways in men and women with osteoporosis.,2025,10.1093/ageing/afaf299,https://pubmed.ncbi.nlm.nih.gov/41104785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,40726387,Investigating the role of disulfidoptosis in spinal cord injury and development of a novel diagnostic model.,2025,10.5152/j.aott.2025.24248,https://pubmed.ncbi.nlm.nih.gov/40726387/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,38534098,A novel mitochondria-related core gene signature to predict the prognosis and evaluate tumour microenvironment in CESC single-cell validation.,2024,10.1111/jcmm.18265,https://pubmed.ncbi.nlm.nih.gov/38534098/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,37522546,Prognosis Prediction of Disulfidptosis-Related Genes in Bladder Cancer and a Comprehensive Analysis of Immunotherapy.,2023,10.1615/critreveukaryotgeneexpr.2023048536,https://pubmed.ncbi.nlm.nih.gov/37522546/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,39000261,Disulfidptosis: A Novel Prognostic Criterion and Potential Treatment Strategy for Diffuse Large B-Cell Lymphoma (DLBCL).,2024,10.3390/ijms25137156,https://pubmed.ncbi.nlm.nih.gov/39000261/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,37746660,Transcriptomic and metabolomic insights into the roles of exogenous β-hydroxybutyrate acid for the development of rumen epithelium in young goats.,2023,10.1016/j.aninu.2023.02.012,https://pubmed.ncbi.nlm.nih.gov/37746660/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,35446108,Long-term mitochondrial stress induces early steps of Tau aggregation by increasing reactive oxygen species levels and affecting cellular proteostasis.,2022,10.1091/mbc.e21-11-0553,https://pubmed.ncbi.nlm.nih.gov/35446108/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA11,ENSG00000174886,Unsafe,28613276,Genetic loci associated with heart rate variability and their effects on cardiac disease risk.,2017,10.1038/ncomms15805,https://pubmed.ncbi.nlm.nih.gov/28613276/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,42230543,An integrative mendelian randomisation and drug mechanism framework for target prioritisation and therapeutic repurposing in major depression.,2026,10.1038/s41398-026-04137-9,https://pubmed.ncbi.nlm.nih.gov/42230543/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,42021405,SIRT5-RNF126 coordinated regulation of METTL17 stability controls mitochondrial function and glioma progression.,2026,10.1186/s13578-026-01570-7,https://pubmed.ncbi.nlm.nih.gov/42021405/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,40974490,Fuzheng Huayu recipe inhibits alveolar macrophage M2 polarization and oxidative phosphorylation via METTL3-mediated NDUFA2 m6A modification.,2025,10.1007/s10863-025-10074-x,https://pubmed.ncbi.nlm.nih.gov/40974490/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,42380087,α-ketoglutarate accumulation orchestrates immunosuppressive metabolic remodeling to drive cetuximab resistance in metastatic colorectal cancer.,2026,10.1038/s41419-026-09001-8,https://pubmed.ncbi.nlm.nih.gov/42380087/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,40926280,Intestinal epithelial Dicer1 regulates gut microbiome and Alzheimer's pathology in App-knock-in mice.,2025,10.1186/s13195-025-01849-w,https://pubmed.ncbi.nlm.nih.gov/40926280/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,42586397,Stephania cepharantha Hayata (Baiyaozi) attenuates cirrhosis-associated intestinal barrier injury by restoring mitochondrial function and suppressing PI3K/AKT signaling.,2027,10.1016/j.jep.2026.122308,https://pubmed.ncbi.nlm.nih.gov/42586397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,39974424,Cuproptosis-related genes signature could predict prognosis and the response of immunotherapy in cervical cancer.,2025,10.21037/tcr-24-641,https://pubmed.ncbi.nlm.nih.gov/39974424/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,40496861,Exploring the role of mitochondrial metabolism and immune infiltration in myocardial infarction: novel insights from bioinformatics and experimental validation.,2025,10.3389/fimmu.2025.1543584,https://pubmed.ncbi.nlm.nih.gov/40496861/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,41628713,Impact of metformin use during pregnancy on fetal congenital malformations across 11 organ systems: a meta-analysis and drug-target Mendelian randomization study.,2026,10.1016/j.diabres.2026.113118,https://pubmed.ncbi.nlm.nih.gov/41628713/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,39978101,Exposure to an environmentally relevant concentration of chlorpyrifos induces transcriptional changes and neurotoxicity in Poecilia gillii without clear behavioral effects.,2025,10.1016/j.ecoenv.2025.117900,https://pubmed.ncbi.nlm.nih.gov/39978101/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,40591190,Development and validation of a prognostic model for efferocytosis-associated genes in cervical squamous cell carcinoma.,2025,10.1007/s12672-025-02901-9,https://pubmed.ncbi.nlm.nih.gov/40591190/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,40069611,Identification of key LncRNAs and mRNAs associated with intramuscular fat in pig via WGCNA.,2025,10.1186/s12864-025-11427-x,https://pubmed.ncbi.nlm.nih.gov/40069611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,38419527,Integrative analysis of metabolism subtypes and identification of prognostic metabolism-related genes for glioblastoma.,2024,10.1042/bsr20231400,https://pubmed.ncbi.nlm.nih.gov/38419527/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,40036166,NOC2L Promotes Paclitaxel Resistance in Various Types of Ovarian Cancers by Decreasing NDUFA4 through Histone Acetylation Suppression.,2025,10.1158/1535-7163.mct-24-0512,https://pubmed.ncbi.nlm.nih.gov/40036166/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,38808333,"Integrated analysis of muscle transcriptome, miRNA, and proteome of Chinese indigenous breed Ningxiang pig in three developmental stages.",2024,10.3389/fgene.2024.1393834,https://pubmed.ncbi.nlm.nih.gov/38808333/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,38065351,Comparative studies on the chemical composition and pharmacological effects of vinegar-processed antler glue modified from Lei Gong Pao Zhi Lun and traditional water-processed antler glue.,2024,10.1016/j.jep.2023.117508,https://pubmed.ncbi.nlm.nih.gov/38065351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,38130933,Particulate matter 10 induces oxidative stress and apoptosis in rhesus macaques skin fibroblast.,2023,10.7717/peerj.16589,https://pubmed.ncbi.nlm.nih.gov/38130933/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,37168668,Genetic variations in the retrograde endocannabinoid signaling pathway in Chinese patients with major depressive disorder.,2023,10.3389/fneur.2023.1153509,https://pubmed.ncbi.nlm.nih.gov/37168668/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,35902387,Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer's disease risk in the general population: a Mendelian randomisation study.,2022,10.1007/s00125-022-05743-0,https://pubmed.ncbi.nlm.nih.gov/35902387/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,34453106,Pituitary P62 deficiency leads to female infertility by impairing luteinizing hormone production.,2021,10.1038/s12276-021-00661-4,https://pubmed.ncbi.nlm.nih.gov/34453106/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,42554914,Evaluation of an Integrated In Silico-In Vitro Pipeline for Predicting Mitochondrial Complex I-Mediated Neurotoxicity of Chlorpyrifos.,2026,10.1007/s12640-026-00816-z,https://pubmed.ncbi.nlm.nih.gov/42554914/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,34276768,Discovery and Validation of Key Biomarkers Based on Immune Infiltrates in Alzheimer's Disease.,2021,10.3389/fgene.2021.658323,https://pubmed.ncbi.nlm.nih.gov/34276768/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,35371279,Expression and Regulation Network of HDAC3 in Acute Myeloid Leukemia and the Implication for Targeted Therapy Based on Multidataset Data Mining.,2022,10.1155/2022/4703524,https://pubmed.ncbi.nlm.nih.gov/35371279/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,30056117,Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons.,2018,10.1016/j.neuroscience.2018.07.029,https://pubmed.ncbi.nlm.nih.gov/30056117/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA2,ENSG00000131495,Unsafe,22921536,Ubiquitin proteasome system in Parkinson's disease: a keeper or a witness?,2012,10.1016/j.expneurol.2012.08.008,https://pubmed.ncbi.nlm.nih.gov/22921536/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,41660605,A housekeeping gene search to analyze expression changes of individual genes in Macaca mulatta.,2025,10.18699/vjgb-25-138,https://pubmed.ncbi.nlm.nih.gov/41660605/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,40274954,Identification and verification of mitochondria-related genes biomarkers associated with immune infiltration for COPD using WGCNA and machine learning algorithms.,2025,10.1038/s41598-025-99002-y,https://pubmed.ncbi.nlm.nih.gov/40274954/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,41364140,Mitochondrial energy metabolism genes as prognostic biomarkers in clear cell renal cell carcinoma via single-cell and bulk RNA sequencing analyses.,2025,10.1007/s12672-025-04224-1,https://pubmed.ncbi.nlm.nih.gov/41364140/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,39829059,Role of mitochondrial complex I genes in host plant expansion of Bactrocera tau (Tephritidae: Diptera) by CRISPR/Cas9 system.,2026,10.1111/1744-7917.13495,https://pubmed.ncbi.nlm.nih.gov/39829059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,40979532,Molecular pathogenesis of Alzheimer's disease onset in a mouse model: effects of cannabidiol treatment.,2025,10.3389/fnins.2025.1667585,https://pubmed.ncbi.nlm.nih.gov/40979532/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,40509003,"Protective Effects of Astaxanthin on Thioacetamide-Induced Hepatopancreatic Damage in &lt;i&gt;Procambarus clarkii&lt;/i&gt;: Insights from Biochemical, Histological, and Metabolomic Analyses.",2025,10.3390/ani15111537,https://pubmed.ncbi.nlm.nih.gov/40509003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,38181234,Association of abnormal NDUFB2 and UQCRH expression with venous thromboembolism in patients with liver cirrhosis.,2024,10.1097/md.0000000000036868,https://pubmed.ncbi.nlm.nih.gov/38181234/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,39765827,"The Novel Elemene Derivative, OMe-Ph-Elemene, Attenuates Oxidative Phosphorylation and Facilitates Apoptosis by Inducing Intracellular Reactive Oxygen Species.",2024,10.3390/antiox13121499,https://pubmed.ncbi.nlm.nih.gov/39765827/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,32989924,ndufa7 plays a critical role in cardiac hypertrophy.,2020,10.1111/jcmm.15921,https://pubmed.ncbi.nlm.nih.gov/32989924/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,40135438,C-Terminal Hsp90 Inhibitors Overcome MEK and BRAF Inhibitor Resistance in Melanoma.,2025,10.1111/jcmm.70489,https://pubmed.ncbi.nlm.nih.gov/40135438/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,40141284,Single-Cell Analysis of Molecular Mechanisms in Rapid Antler Osteogenesis During Growth and Ossification Stages.,2025,10.3390/ijms26062642,https://pubmed.ncbi.nlm.nih.gov/40141284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,38356716,Gene Expression Profile Analysis of the Molecular Mechanism of HOXD10 Regulation of Epithelial Ovarian Cancer Cells.,2024,10.7150/jca.90970,https://pubmed.ncbi.nlm.nih.gov/38356716/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,40579256,MRI-Based Radiomic Biomarkers for Non-invasive Assessment of Liver Fibrosis in MASLD: Diagnostic Performance and Molecular Mechanisms in a Rat Model.,2025,10.1016/j.acra.2025.05.069,https://pubmed.ncbi.nlm.nih.gov/40579256/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,36499081,Respirasome Proteins Are Regulated by Sex-Hormone Interactions in the Brain.,2022,10.3390/ijms232314754,https://pubmed.ncbi.nlm.nih.gov/36499081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,38958071,Circulating B Cell-Derived Small RNA Delivered by Extracellular Vesicles: A Dialogue Mechanism for Long-Range Targeted Renal Mitochondrial Injury in Obesity.,2024,10.1002/smll.202402526,https://pubmed.ncbi.nlm.nih.gov/38958071/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,33952343,Proteomic analysis of human frontal and temporal cortex using iTRAQ-based 2D LC-MS/MS.,2021,10.1186/s41016-021-00241-5,https://pubmed.ncbi.nlm.nih.gov/33952343/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,34478872,"Downregulation of a mitochondrial micropeptide, MPM, promotes hepatoma metastasis by enhancing mitochondrial complex I activity.",2022,10.1016/j.ymthe.2021.08.032,https://pubmed.ncbi.nlm.nih.gov/34478872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,30245030,Bi-allelic Mutations in NDUFA6 Establish Its Role in Early-Onset Isolated Mitochondrial Complex I Deficiency.,2018,10.1016/j.ajhg.2018.08.013,https://pubmed.ncbi.nlm.nih.gov/30245030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,38770619,The ameliorative mechanism of Lactiplantibacillus plantarum NJAU-01 against D-galactose induced oxidative stress: a hepatic proteomics and gut microbiota analysis.,2024,10.1039/d4fo00406j,https://pubmed.ncbi.nlm.nih.gov/38770619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,35154017,In Vivo and In Vitro Matured Oocytes From Mice of Advanced Reproductive Age Exhibit Alternative Splicing Processes for Mitochondrial Oxidative Phosphorylation.,2022,10.3389/fendo.2022.816606,https://pubmed.ncbi.nlm.nih.gov/35154017/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NDUFA7,ENSG00000267855,Unsafe,28584723,Selection of housekeeping genes as internal controls for quantitative RT-PCR analysis of the veined rapa whelk (Rapana venosa).,2017,10.7717/peerj.3398,https://pubmed.ncbi.nlm.nih.gov/28584723/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,42868715,Machine learning and multi-omics analyses reveal CLDN1 as a candidate marker associated with colorectal cancer invasion and nutlin-3a (-) response.,2026,10.1016/j.tranon.2026.103078,https://pubmed.ncbi.nlm.nih.gov/42868715/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,41594487,Evaluation of the Prevalence of Genetic Variants at the Nebulette Locus in Cavalier King Charles Spaniels.,2026,10.3390/ani16020298,https://pubmed.ncbi.nlm.nih.gov/41594487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,40023092,LIM and SH3 protein 2 (Lasp2) is a novel pregnane X receptor target gene in mouse liver.,2025,10.1016/j.molpha.2025.100019,https://pubmed.ncbi.nlm.nih.gov/40023092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,41472124,Genetic Basis of Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniel Dogs-A Review.,2025,10.3390/vetsci12121144,https://pubmed.ncbi.nlm.nih.gov/41472124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,42023217,Single cell transcriptomics reveals dendritic cell subsets in bovine afferent lymph and immune cell-resolved responses to BCG vaccination.,2026,10.3389/fimmu.2026.1764014,https://pubmed.ncbi.nlm.nih.gov/42023217/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,41417205,"Integrating differential gene expression and Mendelian randomization analyses reveal novel gene for prognosis, immune response, and drug sensitivity in lung cancer.",2025,10.1007/s12672-025-04277-2,https://pubmed.ncbi.nlm.nih.gov/41417205/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,38384848,Upregulated α-actinin-1 impairs endometrial epithelial cell adhesion by downregulating NEBL in recurrent implantation failure.,2024,10.1016/j.isci.2024.109046,https://pubmed.ncbi.nlm.nih.gov/38384848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,42817911,The Heterogeneity of the Neurovascular Unit in the Optic Nerve Head During Glaucomatous Neurodegeneration Based on Single-Cell RNA Sequencing.,2026,10.1096/fj.202602523rr,https://pubmed.ncbi.nlm.nih.gov/42817911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,41108936,Single-cell analysis of differential fat deposition in chicken pectoral muscle and abdominal fat tissues.,2025,10.1016/j.psj.2025.105938,https://pubmed.ncbi.nlm.nih.gov/41108936/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,40296161,Integrative DNA methylome and transcriptome analysis identify potential genes on the influence of dilated cardiomyopathy-associated heart failure.,2025,10.1186/s13148-025-01876-2,https://pubmed.ncbi.nlm.nih.gov/40296161/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,38215565,Downregulation of NEBL promotes migration and invasion of clear cell renal cell carcinoma by inducing epithelial-mesenchymal transition.,2024,10.1016/j.prp.2023.155068,https://pubmed.ncbi.nlm.nih.gov/38215565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,39765701,Identifying Significant SNPs of the Total Number of Piglets Born and Their Relationship with Leg Bumps in Pigs.,2024,10.3390/biology13121034,https://pubmed.ncbi.nlm.nih.gov/39765701/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,39310266,A Circular Network of Coregulated L-Threonine and L-Tryptophan Metabolism Dictates Acute Lower Limb Ischemic Injury.,2024,10.7150/ijms.102177,https://pubmed.ncbi.nlm.nih.gov/39310266/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,40442228,Application of RNA-seq for single nucleotide variation identification in a cohort of patients with hypertrophic cardiomyopathy.,2025,10.1038/s41598-025-03226-x,https://pubmed.ncbi.nlm.nih.gov/40442228/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,36009085,Integrated Analysis of Cortex Single-Cell Transcriptome and Serum Proteome Reveals the Novel Biomarkers in Alzheimer's Disease.,2022,10.3390/brainsci12081022,https://pubmed.ncbi.nlm.nih.gov/36009085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,33861145,Deficiency in nebulin repeats of sarcomeric nebulette is detrimental for cardiomyocyte tolerance to exercise and biomechanical stress.,2021,10.1152/ajpheart.00732.2020,https://pubmed.ncbi.nlm.nih.gov/33861145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,34473707,The genetic consequences of dog breed formation-Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels.,2021,10.1371/journal.pgen.1009726,https://pubmed.ncbi.nlm.nih.gov/34473707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,35854639,Bioinformatics Profiling and Experimental Validation of 4 Differentially-Expressed LIM Genes in the Course of Colorectal-Adenoma-Carcinoma.,2022,10.12659/msm.937081,https://pubmed.ncbi.nlm.nih.gov/35854639/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,34977336,NEBL and AKT1 maybe new targets to eliminate the colorectal cancer cells resistance to oncolytic effect of vesicular stomatitis virus M-protein.,2021,10.1016/j.omto.2021.11.013,https://pubmed.ncbi.nlm.nih.gov/34977336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,36553559,Genetic Variants at the Nebulette Locus Are Associated with Myxomatous Mitral Valve Disease Severity in Cavalier King Charles Spaniels.,2022,10.3390/genes13122292,https://pubmed.ncbi.nlm.nih.gov/36553559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,38737702,Identification of immune-related prognostic biomarkers in triple-negative breast cancer.,2024,10.21037/tcr-23-1554,https://pubmed.ncbi.nlm.nih.gov/38737702/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,38093163,Machine learning and experiments identifies SPINK1 as a candidate diagnostic and prognostic biomarker for hepatocellular carcinoma.,2023,10.1007/s12672-023-00849-2,https://pubmed.ncbi.nlm.nih.gov/38093163/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,37511632,"New Gene Markers of Exosomal Regulation Are Involved in Porcine Granulosa Cell Adhesion, Migration, and Proliferation.",2023,10.3390/ijms241411873,https://pubmed.ncbi.nlm.nih.gov/37511632/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,35480093,Identification of a 12-Gene Signature and Hub Genes Involved in Kidney Wilms Tumor via Integrated Bioinformatics Analysis.,2022,10.3389/fonc.2022.877796,https://pubmed.ncbi.nlm.nih.gov/35480093/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,34202615,Global Proteomic Profiling of Pediatric AML: A Pilot Study.,2021,10.3390/cancers13133161,https://pubmed.ncbi.nlm.nih.gov/34202615/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,34484284,Gene Signatures and Prognostic Values of N6-Methyladenosine Related Genes in Ovarian Cancer.,2021,10.3389/fgene.2021.542457,https://pubmed.ncbi.nlm.nih.gov/34484284/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,34383714,Altered pattern of circulating miRNAs in HIV lipodystrophy perturbs key adipose differentiation and inflammation pathways.,2021,10.1172/jci.insight.150399,https://pubmed.ncbi.nlm.nih.gov/34383714/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,34371182,Comprehensive transcriptome-wide analysis of spliceopathy correction of myotonic dystrophy using CRISPR-Cas9 in iPSCs-derived cardiomyocytes.,2022,10.1016/j.ymthe.2021.08.004,https://pubmed.ncbi.nlm.nih.gov/34371182/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,27171184,Genome-Wide Association Study Identifies Novel Susceptibility Genes Associated with Coronary Artery Aneurysm Formation in Kawasaki Disease.,2016,10.1371/journal.pone.0154943,https://pubmed.ncbi.nlm.nih.gov/27171184/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,21430528,Genetics of sudden cardiac death syndromes.,2011,10.1097/hco.0b013e3283459893,https://pubmed.ncbi.nlm.nih.gov/21430528/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEBL,ENSG00000078114,Unsafe,17521656,"Plasmodium falciparum Pf34, a novel GPI-anchored rhoptry protein found in detergent-resistant microdomains.",2007,10.1016/j.ijpara.2007.03.013,https://pubmed.ncbi.nlm.nih.gov/17521656/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,42741185,Comorbidity of anxiety and dry eye disease: shared biomarkers and immune responses.,2026,10.3389/fimmu.2026.1854853,https://pubmed.ncbi.nlm.nih.gov/42741185/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,42660029,Environmental DINCH promotes the progression and EMT of hepatocellular carcinoma by upregulating NEDD1.,2026,10.1016/j.ecoenv.2026.120703,https://pubmed.ncbi.nlm.nih.gov/42660029/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,41775913,"Multi-omics analysis of NEDD1 in hepatocellular carcinoma: biological function, prognostic value, and clinical significance.",2026,10.1038/s41598-026-42505-z,https://pubmed.ncbi.nlm.nih.gov/41775913/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,42466846,"Genetic determinants of gestational diabetes mellitus in thai pregnant women: role of &lt;i&gt;GCKR, CDKAL1, TCF7L2, NEDD1&lt;/i&gt;, and &lt;i&gt;CMIP&lt;/i&gt; variants.",2026,10.1080/07853890.2026.2703311,https://pubmed.ncbi.nlm.nih.gov/42466846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,41387433,"Cryo-EM structures of plant Augmin reveal coiled-coil assembly, antiparallel dimerization, and NEDD1 binding.",2025,10.1038/s41467-025-66332-4,https://pubmed.ncbi.nlm.nih.gov/41387433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,39247593,NEDD1 Promotes the Development of Lung Adenocarcinoma and Can be Used as a Prognostic Marker.,2024,10.7150/jca.98238,https://pubmed.ncbi.nlm.nih.gov/39247593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,40396914,Structure of the microtubule-anchoring factor NEDD1 bound to the γ-tubulin ring complex.,2025,10.1083/jcb.202410206,https://pubmed.ncbi.nlm.nih.gov/40396914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,38577589,"NEDD1 overexpression increases cell proliferation, tumor immune escape, and drug resistance in LUAD.",2024,10.7150/jca.91671,https://pubmed.ncbi.nlm.nih.gov/38577589/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,40204068,MZT1 protects gastric cancer against glucose starvation through targeting NEDD1.,2025,10.1016/j.lfs.2025.123622,https://pubmed.ncbi.nlm.nih.gov/40204068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,40074789,Structural mechanisms for centrosomal recruitment and organization of the microtubule nucleator γ-TuRC.,2025,10.1038/s41467-025-57729-2,https://pubmed.ncbi.nlm.nih.gov/40074789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,36840486,METTL3 enhances the effect of YTHDF1 on NEDD1 mRNA stability by m6A modification in diffuse large B-cell lymphoma cells.,2023,10.1002/iid3.789,https://pubmed.ncbi.nlm.nih.gov/36840486/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,40229407,Glutamylation of centrosomes ensures their function by recruiting microtubule nucleation factors.,2025,10.1038/s44318-025-00435-y,https://pubmed.ncbi.nlm.nih.gov/40229407/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,39197298,"Integrated analyses of 5 mC, 5hmC methylation and gene expression reveal pathology-associated AKT3 gene and potential biomarkers for Alzheimer's disease.",2024,10.1016/j.jpsychires.2024.08.021,https://pubmed.ncbi.nlm.nih.gov/39197298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,36318115,NEDD1-S411 phosphorylation plays a critical function in the coordination of microtubule nucleation during mitosis.,2022,10.1242/bio.059474,https://pubmed.ncbi.nlm.nih.gov/36318115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,39253524,Muscle growth differences in Lijiang pigs revealed by ATAC-seq multi-omics.,2024,10.3389/fvets.2024.1431248,https://pubmed.ncbi.nlm.nih.gov/39253524/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,35604367,Reconstitution and mechanistic dissection of the human microtubule branching machinery.,2022,10.1083/jcb.202109053,https://pubmed.ncbi.nlm.nih.gov/35604367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,33351100,PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and centriole biogenesis initiations.,2021,10.1083/jcb.202002151,https://pubmed.ncbi.nlm.nih.gov/33351100/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,36347549,"A retrospective single-centered, comprehensive targeted genetic sequencing analysis of prognostic survival using tissues from Korean patients with metastatic renal cell carcinoma after targeted therapy.",2022,10.4111/icu.20210341,https://pubmed.ncbi.nlm.nih.gov/36347549/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,35004728,Circulating Placental Alkaline Phosphatase Expressing Exosomes in Maternal Blood Showed Temporal Regulation of Placental Genes.,2021,10.3389/fmed.2021.758971,https://pubmed.ncbi.nlm.nih.gov/35004728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,31028180,Microtubule nucleation during central spindle assembly requires NEDD1 phosphorylation on serine 405 by Aurora A.,2019,10.1242/jcs.231118,https://pubmed.ncbi.nlm.nih.gov/31028180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,35787744,Self-assembly of pericentriolar material in interphase cells lacking centrioles.,2022,10.7554/elife.77892,https://pubmed.ncbi.nlm.nih.gov/35787744/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,23106787,Intraperitoneal delivery of a small interfering RNA targeting NEDD1 prolongs the survival of scirrhous gastric cancer model mice.,2013,10.1111/cas.12054,https://pubmed.ncbi.nlm.nih.gov/23106787/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,19243593,The centrosome protein NEDD1 as a potential pharmacological target to induce cell cycle arrest.,2009,10.1186/1476-4598-8-10,https://pubmed.ncbi.nlm.nih.gov/19243593/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD1,ENSG00000139350,Unsafe,24025740,Impact of vitrification on the meiotic spindle and components of the microtubule-organizing center in mouse mature oocytes.,2013,10.1095/biolreprod.113.108167,https://pubmed.ncbi.nlm.nih.gov/24025740/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42602476,Neddylation-dependent RAB40-Cullin5 E3 ligase complex controls ubiquitin-mediated proteasomal degradation of DNAJC13.,2026,10.1016/j.bbadva.2026.100200,https://pubmed.ncbi.nlm.nih.gov/42602476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42262027,NEDD8 Promotes the Progression and Inflammation of Keratoconus by Increasing the Expression of YAP1.,2026,10.1167/iovs.67.6.14,https://pubmed.ncbi.nlm.nih.gov/42262027/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42756518,FBXO11 and FBXO32 synergistically activate innate immunity against hepatitis B virus in a NEDD8-dependent manner.,2026,10.3389/fimmu.2026.1833429,https://pubmed.ncbi.nlm.nih.gov/42756518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42723894,PSMA6 drives non-small cell lung cancer progression by stabilizing NEDD8 and activating NF-κB signaling.,2026,10.21037/tlcr-2026-0781,https://pubmed.ncbi.nlm.nih.gov/42723894/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42216099,Neddylation is indispensable for early meiotic progression in spermatocytes via destabilizing HORMAD1 by SCF ubiquitin E3 ligase during synapsis.,2026,10.1186/s13578-026-01597-w,https://pubmed.ncbi.nlm.nih.gov/42216099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42348677,"Ubiquitin-like proteins NEDD8 and SUMO2 control epithelial homeostasis, regeneration, and inflammation.",2026,10.1126/science.aeb3900,https://pubmed.ncbi.nlm.nih.gov/42348677/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42813898,Neddylation inhibition alleviates polycystic ovary syndrome by regulating granulosa cell function and androgen synthesis.,2026,10.1093/biolre/ioag193,https://pubmed.ncbi.nlm.nih.gov/42813898/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42452912,A Noncanonical Protein Degradation Pathway That Regulates Germ Cell Maintenance.,2026,10.1111/cpr.70259,https://pubmed.ncbi.nlm.nih.gov/42452912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,41662890,NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke via mediating neddylation of NRF2.,2026,10.1016/j.jstrokecerebrovasdis.2026.108582,https://pubmed.ncbi.nlm.nih.gov/41662890/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42128900,EXOSC4 as a novel regulator of neddylation in acute myeloid leukemia.,2026,10.1038/s41598-026-52987-6,https://pubmed.ncbi.nlm.nih.gov/42128900/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42639435,Flavokawain A inhibits high glucose-induced malignant progression of lung cancer cells by suppressing PRMT5-mediated PTEN neddylation and nuclear translocation.,2026,10.3892/ol.2026.15818,https://pubmed.ncbi.nlm.nih.gov/42639435/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,41619450,"The NEDD8-activating enzyme inhibitor MLN4924 reduces inflammation, blood-brain barrier disruption and brain injury after intracerebral hemorrhage in mice.",2026,10.1016/j.jneuroim.2026.578872,https://pubmed.ncbi.nlm.nih.gov/41619450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42544581,Protein neddylation as a therapeutic target: challenges and opportunities.,2026,10.1172/jci206924,https://pubmed.ncbi.nlm.nih.gov/42544581/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42543398,Neddylation of NFATc1 and Runx2 regulates osteoclast-osteoblast balance and represents a dual-action therapeutic target for postmenopausal osteoporosis.,2026,10.1038/s12276-026-01784-2,https://pubmed.ncbi.nlm.nih.gov/42543398/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42380110,E3 ligase LMO7 promotes ALKBH2 ubiquitination to sensitize MGMT-deficient glioblastoma to temozolomide.,2026,10.1038/s41419-026-09073-6,https://pubmed.ncbi.nlm.nih.gov/42380110/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42111249,The modifier matrix: emerging roles of ubiquitin-like proteins in Alzheimer's disease.,2026,10.1186/s44477-026-00031-2,https://pubmed.ncbi.nlm.nih.gov/42111249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42637928,Neddylation as a molecular integrator of metabolic dysfunction and endothelial dysfunction in type 2 diabetes.,2026,10.1038/s41401-026-01910-w,https://pubmed.ncbi.nlm.nih.gov/42637928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,41866577,Complete NUB1 depletion in ER - negative breast cancer progression in paired primary-metastatic cases: a case series.,2026,10.1186/s13256-026-05939-7,https://pubmed.ncbi.nlm.nih.gov/41866577/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,41878332,AP39 alleviates HHCY-induced myocardial remodeling by regulating FUNDC1-mediated mitochondrial dynamics via S-sulfhydration of NEDD8/CUL4B.,2026,10.3389/fphar.2026.1729145,https://pubmed.ncbi.nlm.nih.gov/41878332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,40925985,Neddylation regulates the development and function of glutamatergic neurons.,2025,10.1038/s42003-025-08680-x,https://pubmed.ncbi.nlm.nih.gov/40925985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42330494,Cancer-Intrinsic Protein Neddylation Modulates the Intratumoral Immune Landscape to Constrain Immune Checkpoint Blockade Therapy.,2026,10.1158/2326-6066.cir-25-1309,https://pubmed.ncbi.nlm.nih.gov/42330494/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42401166,Aloin suppresses cancer cell growth via autophagy-promoted NEDD8 de-NEDDylation to target GPX4 for ferroptosis induction.,2026,10.1016/j.bioorg.2026.110201,https://pubmed.ncbi.nlm.nih.gov/42401166/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,41540013,"Decoding neddylation in malignancies: molecular mechanisms, biological functions, therapeutic resistance, and clinical potential.",2026,10.1038/s41419-025-08255-y,https://pubmed.ncbi.nlm.nih.gov/41540013/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,41387655,The role of neddylation in colorectal cancer and its therapeutic potential.,2025,10.1007/s12672-025-04264-7,https://pubmed.ncbi.nlm.nih.gov/41387655/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42559520,Discovery of spirocyclic amide scaffolds as novel neddylation E1 inhibitors to suppress the growth and survival of lung cancer cells.,2026,10.1039/d6md00393a,https://pubmed.ncbi.nlm.nih.gov/42559520/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,40261130,NEDDylation Regulates CD8+ T-cell Metabolism and Antitumor Immunity.,2025,10.1158/2326-6066.cir-24-0127,https://pubmed.ncbi.nlm.nih.gov/40261130/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,37865096,Oncolytic virus and inhibitor for NEDD8-activating enzyme pevonedistat: Promising combination for cancer therapy?,2023,10.1016/j.ymthe.2023.10.008,https://pubmed.ncbi.nlm.nih.gov/37865096/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42878659,Cullin-5 RING E3 ligase limits CD8⁺ T-cell persistence and effector responses during chronic antigen stimulation.,2026,10.1158/2326-6066.cir-26-0181,https://pubmed.ncbi.nlm.nih.gov/42878659/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,41498889,Role of HDAC6 in carcinomas.,2026,10.1007/s12672-026-04391-9,https://pubmed.ncbi.nlm.nih.gov/41498889/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42346086,Molecular Functions of Ubiquitin-like Modifiers in Bacterial Infection.,2026,10.3390/cells15121060,https://pubmed.ncbi.nlm.nih.gov/42346086/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,41385186,"NEDD8, stress granules, and amyotrophic lateral sclerosis: unveiling the therapeutic potential of the NEDP1 protease.",2025,10.1042/ebc20253036,https://pubmed.ncbi.nlm.nih.gov/41385186/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42078440,"CUL5-mediated ubiquitination in cancer cell therapy: context-dependent roles, molecular networks, and emerging therapeutic avenues.",2026,10.3389/fmed.2026.1775447,https://pubmed.ncbi.nlm.nih.gov/42078440/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42178458,Identifying Neddylation-modified features to assess prognosis and immune efficacy in hepatocellular carcinoma.,2026,10.1007/s10495-026-02339-6,https://pubmed.ncbi.nlm.nih.gov/42178458/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,42055937,UBA3 reduction sensitizes cancer cells to NAE inhibitors.,2026,10.26508/lsa.202503589,https://pubmed.ncbi.nlm.nih.gov/42055937/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,10597293,Covalent modification of all members of human cullin family proteins by NEDD8.,1999,10.1038/sj.onc.1203093,https://pubmed.ncbi.nlm.nih.gov/10597293/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEDD8,ENSG00000129559,Unsafe,9353319,"Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein.",1997,10.1074/jbc.272.45.28557,https://pubmed.ncbi.nlm.nih.gov/9353319/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,39910812,NEIL3 and TOP2A as key drivers of esophageal cancer through WNT signaling.,2025,10.17305/bb.2025.11365,https://pubmed.ncbi.nlm.nih.gov/39910812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,41394218,Mechanisms of Acetaldehyde-Induced Organ Injury via Impairment of Vascular Endothelial Cells.,2025,10.2147/vhrm.s560614,https://pubmed.ncbi.nlm.nih.gov/41394218/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,40348794,DNA glycosylase (NEIL3) overexpression associated with low tumor immune infiltration and poor overall patient survival in endometrial cancer.,2025,10.1038/s41598-025-00393-9,https://pubmed.ncbi.nlm.nih.gov/40348794/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,41793056,Oxidative Damage Fine-Tunes G-Quadruplex Structures in Human Gene Promoters.,2026,10.1002/anie.202526126,https://pubmed.ncbi.nlm.nih.gov/41793056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,40447877,NEIL3 promotes the carcinogenesis of prostate cancer by activating PI3K/Akt/mTOR signaling.,2025,10.1007/s12672-025-02625-w,https://pubmed.ncbi.nlm.nih.gov/40447877/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,40035863,NEIL3 influences adult neurogenesis and behavioral pattern separation via WNT signaling.,2025,10.1007/s00018-025-05629-5,https://pubmed.ncbi.nlm.nih.gov/40035863/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,40777817,FOXM1 transcriptionally activates NEIL3 to inhibit ferroptosis in lung adenocarcinoma cells.,2025,10.3164/jcbn.24-136,https://pubmed.ncbi.nlm.nih.gov/40777817/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,42223726,Development of a four-gene prognostic signature for hepatocellular carcinoma using TCGA and GEO datasets.,2026,10.1007/s12672-026-05244-1,https://pubmed.ncbi.nlm.nih.gov/42223726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,38663144,NEIL3: A unique DNA glycosylase involved in interstrand DNA crosslink repair.,2024,10.1016/j.dnarep.2024.103680,https://pubmed.ncbi.nlm.nih.gov/38663144/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,42215985,A continuous DNA repairing system for alleviating intervertebral disc degeneration.,2026,10.1186/s12951-026-04615-8,https://pubmed.ncbi.nlm.nih.gov/42215985/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,40263742,NEIL3 Deficiency Enhances HCC Cell Sensitivity to Oxaliplatin by Inhibiting the Fanconi Anaemia Pathway.,2025,10.1002/cbin.70023,https://pubmed.ncbi.nlm.nih.gov/40263742/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,41015225,NEIL3 shapes hippocampal network dynamics and fear memory through modulation of PV&lt;sup&gt;+&lt;/sup&gt; interneurons.,2025,10.1016/j.pneurobio.2025.102832,https://pubmed.ncbi.nlm.nih.gov/41015225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,41402347,Unravelling TPX2-centered co-expression networks as key drivers of aggressive prostate cancer.,2025,10.1038/s41598-025-27704-4,https://pubmed.ncbi.nlm.nih.gov/41402347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,39342941,NEIL3 Upregulated by TFAP2A Promotes M2 Polarization of Macrophages in Liver Cancer via the Mediation of Glutamine Metabolism.,2025,10.1159/000540804,https://pubmed.ncbi.nlm.nih.gov/39342941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,38522610,Dissecting gene expression networks in the developing hippocampus through the lens of NEIL3 depletion.,2024,10.1016/j.pneurobio.2024.102599,https://pubmed.ncbi.nlm.nih.gov/38522610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,42731283,Integrating multi-omics to reveal the regulatory mechanisms of microfilament cytoskeleton in programmed cell death during seed cryopreservation.,2026,10.1016/j.plaphy.2026.111738,https://pubmed.ncbi.nlm.nih.gov/42731283/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,36497204,Biological Functions of the DNA Glycosylase NEIL3 and Its Role in Disease Progression Including Cancer.,2022,10.3390/cancers14235722,https://pubmed.ncbi.nlm.nih.gov/36497204/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,41711078,Xenium-based spatial transcriptomic analyses uncover prognosis-associated heterogeneity in the tumor microenvironment (TME) of angioimmunoblastic T-cell lymphoma (AITL).,2026,10.1002/path.70035,https://pubmed.ncbi.nlm.nih.gov/41711078/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,36612106,Pan-Cancer Landscape of NEIL3 in Tumor Microenvironment: A Promising Predictor for Chemotherapy and Immunotherapy.,2022,10.3390/cancers15010109,https://pubmed.ncbi.nlm.nih.gov/36612106/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,38347781,"Transcription Factor MAZ Potentiates the Upregulated NEIL3-mediated Aerobic Glycolysis, thereby Promoting Angiogenesis in Hepatocellular Carcinoma.",2024,10.2174/0115680096265896231226062212,https://pubmed.ncbi.nlm.nih.gov/38347781/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,36816967,Prognostic biomarker NEIL3 and its association with immune infiltration in renal clear cell carcinoma.,2023,10.3389/fonc.2023.1073941,https://pubmed.ncbi.nlm.nih.gov/36816967/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,40356980,Bioinformatics analysis across pan-cancer and experimental validation in hepatocellular carcinoma revealed the oncogenic role of SF3B6.,2025,10.3389/fphar.2025.1516534,https://pubmed.ncbi.nlm.nih.gov/40356980/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,38831301,Identifying disulfidptosis subtypes in hepatocellular carcinoma through machine learning and preliminary exploration of its connection with immunotherapy.,2024,10.1186/s12935-024-03387-1,https://pubmed.ncbi.nlm.nih.gov/38831301/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,35535347,NEIL3 Mediates Lung Cancer Progression and Modulates PI3K/AKT/mTOR Signaling: A Potential Therapeutic Target.,2022,10.1155/2022/8348499,https://pubmed.ncbi.nlm.nih.gov/35535347/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,33525928,"Phase I studies of peptide vaccine cocktails derived from GPC3, WDRPUH and NEIL3 for advanced hepatocellular carcinoma.",2021,10.2217/imt-2020-0278,https://pubmed.ncbi.nlm.nih.gov/33525928/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,34591415,Loss of NEIL3 activates radiotherapy resistance in the progression of prostate cancer.,2021,10.20892/j.issn.2095-3941.2020.0550,https://pubmed.ncbi.nlm.nih.gov/34591415/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,33879165,NEIL3 may act as a potential prognostic biomarker for lung adenocarcinoma.,2021,10.1186/s12935-021-01938-4,https://pubmed.ncbi.nlm.nih.gov/33879165/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,34988395,DNA repair enzyme NEIL3 enables a stable neural representation of space by shaping transcription in hippocampal neurons.,2021,10.1016/j.isci.2021.103470,https://pubmed.ncbi.nlm.nih.gov/34988395/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,34045188,NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis.,2021,10.1158/0008-5472.can-20-1028,https://pubmed.ncbi.nlm.nih.gov/34045188/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,37923899,DNA damage repair-related gene signature for identifying the immune status and predicting the prognosis of hepatocellular carcinoma.,2023,10.1038/s41598-023-45999-z,https://pubmed.ncbi.nlm.nih.gov/37923899/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,35656315,A DNA Damage Repair Gene Signature Associated With Immunotherapy Response and Clinical Prognosis in Clear Cell Renal Cell Carcinoma.,2022,10.3389/fgene.2022.798846,https://pubmed.ncbi.nlm.nih.gov/35656315/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,36267406,Development and verification of the glycolysis-associated and immune-related prognosis signature for hepatocellular carcinoma.,2022,10.3389/fgene.2022.955673,https://pubmed.ncbi.nlm.nih.gov/36267406/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,36408135,A novel DNA damage repair-related signature for predicting prognositc and treatment response in non-small lung cancer.,2022,10.3389/fonc.2022.961274,https://pubmed.ncbi.nlm.nih.gov/36408135/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,22365498,Release from quiescence stimulates the expression of human NEIL3 under the control of the Ras dependent ERK-MAP kinase pathway.,2012,10.1016/j.dnarep.2012.01.007,https://pubmed.ncbi.nlm.nih.gov/22365498/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,19426544,Expression patterns of Neil3 during embryonic brain development and neoplasia.,2009,10.1186/1471-2202-10-45,https://pubmed.ncbi.nlm.nih.gov/19426544/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,16428305,Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein.,2005,10.1093/jb/mvi168,https://pubmed.ncbi.nlm.nih.gov/16428305/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEIL3,ENSG00000109674,Unsafe,12433996,Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA.,2002,10.1093/nar/gkf618,https://pubmed.ncbi.nlm.nih.gov/12433996/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,41427545,Extracellular matrix-derived mechanical force induces CDK4/6 inhibitor resistance by inhibiting NEK10 dependent cell cycle regulation in breast cancer.,2026,10.1097/js9.0000000000004527,https://pubmed.ncbi.nlm.nih.gov/41427545/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,41716219,Mutational insights and &lt;i&gt;in silico&lt;/i&gt; characterization of &lt;i&gt;NEK&lt;/i&gt; family kinases in OSCC patients from the Pakistani population.,2025,10.3389/fbinf.2025.1750649,https://pubmed.ncbi.nlm.nih.gov/41716219/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,40934128,NEK10 Drives Lipid Disturbances That Induce G2/M Phase Arrest in Renal Tubular Cells under Albumin Overload.,2025,10.1159/000547768,https://pubmed.ncbi.nlm.nih.gov/40934128/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,40889272,Genetic predisposition to persistent fatigue after a diagnosis of colorectal cancer.,2025,10.1093/jnci/djaf140,https://pubmed.ncbi.nlm.nih.gov/40889272/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,39379991,"NEK10 kinase ablation affects mitochondrial morphology, function and protein phosphorylation status.",2024,10.1186/s12953-024-00234-z,https://pubmed.ncbi.nlm.nih.gov/39379991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,38683979,β-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells.,2024,10.1073/pnas.2300606121,https://pubmed.ncbi.nlm.nih.gov/38683979/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,38534317,The Mitochondrial Connection: The Nek Kinases' New Functional Axis in Mitochondrial Homeostasis.,2024,10.3390/cells13060473,https://pubmed.ncbi.nlm.nih.gov/38534317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,41117990,Identification and characterization of lLF2 as a prognostic biomarker in HER2-positive breast cancer using Mendelian randomization and machine learning.,2025,10.1007/s12672-025-03762-y,https://pubmed.ncbi.nlm.nih.gov/41117990/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,39029088,Prognostic value and immune infiltration of the NEK family in clear cell renal cell carcinoma.,2024,10.1097/md.0000000000038961,https://pubmed.ncbi.nlm.nih.gov/39029088/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,38706902,Prognostic value and therapeutic potential of NEK family in stomach adenocarcinoma.,2024,10.7150/jca.90197,https://pubmed.ncbi.nlm.nih.gov/38706902/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,38767515,NEKL-4 regulates microtubule stability and mitochondrial health in ciliated neurons.,2024,10.1083/jcb.202402006,https://pubmed.ncbi.nlm.nih.gov/38767515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,32368190,NEK10 interactome and depletion reveal new roles in mitochondria.,2020,10.1186/s12953-020-00160-w,https://pubmed.ncbi.nlm.nih.gov/32368190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,35368696,Integrative Analysis of the Expression Levels and Prognostic Values for NEK Family Members in Breast Cancer.,2022,10.3389/fgene.2022.798170,https://pubmed.ncbi.nlm.nih.gov/35368696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,39475132,Identification of fibrosis-associated lncRNAs in diabetic cardiomyopathy patients.,2024,10.5603/ep.100459,https://pubmed.ncbi.nlm.nih.gov/39475132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,32414360,"Homozygous truncating NEK10 mutation, associated with primary ciliary dyskinesia: a case report.",2020,10.1186/s12890-020-1175-1,https://pubmed.ncbi.nlm.nih.gov/32414360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,37998386,Ciliary Ultrastructure Assessed by Transmission Electron Microscopy in Adults with Bronchiectasis and Suspected Primary Ciliary Dyskinesia but Inconclusive Genotype.,2023,10.3390/cells12222651,https://pubmed.ncbi.nlm.nih.gov/37998386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,32561851,NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity.,2020,10.1038/s41388-020-1361-x,https://pubmed.ncbi.nlm.nih.gov/32561851/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,29581457,Counterregulation of cAMP-directed kinase activities controls ciliogenesis.,2018,10.1038/s41467-018-03643-9,https://pubmed.ncbi.nlm.nih.gov/29581457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,31959991,A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance.,2020,10.1038/s41591-019-0730-x,https://pubmed.ncbi.nlm.nih.gov/31959991/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,35469018,Cancer-cell-secreted miR-122 suppresses O-GlcNAcylation to promote skeletal muscle proteolysis.,2022,10.1038/s41556-022-00893-0,https://pubmed.ncbi.nlm.nih.gov/35469018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,40733180,Tricyclic Isatin Derivatives as Anti-Inflammatory Compounds with High Kinase Binding Affinity.,2025,10.3390/molecules30142914,https://pubmed.ncbi.nlm.nih.gov/40733180/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,33673578,On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage Response.,2021,10.3390/cells10030507,https://pubmed.ncbi.nlm.nih.gov/33673578/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,30324649,Analysis of changes to lncRNAs and their target mRNAs in murine jejunum after radiation treatment.,2018,10.1111/jcmm.13940,https://pubmed.ncbi.nlm.nih.gov/30324649/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,29296234,The pyrazolyl-urea GeGe3 inhibits tumor angiogenesis and reveals dystrophia myotonica protein kinase (DMPK)1 as a novel angiogenesis target.,2017,10.18632/oncotarget.22598,https://pubmed.ncbi.nlm.nih.gov/29296234/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,27491861,LRG1 mRNA expression in breast cancer associates with PIK3CA genotype and with aromatase inhibitor therapy outcome.,2016,10.1016/j.molonc.2016.07.004,https://pubmed.ncbi.nlm.nih.gov/27491861/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,23132929,Cell cycle regulation by the NEK family of protein kinases.,2012,10.1242/jcs.111195,https://pubmed.ncbi.nlm.nih.gov/23132929/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,24943594,Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium.,2014,10.1093/hmg/ddu311,https://pubmed.ncbi.nlm.nih.gov/24943594/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK10,ENSG00000163491,Unsafe,19330027,Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.,2009,10.1038/ng.354,https://pubmed.ncbi.nlm.nih.gov/19330027/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,42287558,A NEK2/ZWINT-NDC80 regulatory axis drives bladder cancer progression and chemoresistance.,2026,10.1007/s12672-026-05435-w,https://pubmed.ncbi.nlm.nih.gov/42287558/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,42291266,NEK2A regulates PLIN2 expression through a SERBP1 dependent pathway.,2026,10.1016/j.isci.2026.116254,https://pubmed.ncbi.nlm.nih.gov/42291266/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,42133805,"NEK2 drives pathogenesis, drug resistance, and LMP1 expression in EBV-positive non-Hodgkin lymphoma.",2026,10.1073/pnas.2535550123,https://pubmed.ncbi.nlm.nih.gov/42133805/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,42550427,NEK2 is essential for spindle assembly checkpoint regulation and cytoskeleton organization in porcine oocyte meiotic maturation.,2026,10.1007/s11010-026-05674-z,https://pubmed.ncbi.nlm.nih.gov/42550427/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,42886303,NEK2 promotes trastuzumab resistance in gastric cancer through WTAP/YTHDF1-dependent m6A regulation of FN1.,2026,10.1007/s11033-026-12927-z,https://pubmed.ncbi.nlm.nih.gov/42886303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,42550868,Bioinformatics and experimental studies of atherosclerosis-related endothelial dysfunction genes in renal calculi and exploration of their molecular mechanisms.,2026,10.1371/journal.pone.0354595,https://pubmed.ncbi.nlm.nih.gov/42550868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,41963470,NEK2 promotes oral squamous cell carcinoma progression and serves as a diagnostic and therapeutic target.,2026,10.1038/s41598-026-47174-6,https://pubmed.ncbi.nlm.nih.gov/41963470/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,42902457,NEK2 Promotes OSCC Invasion and Metastasis by Activating TNF-α Signaling Through Impairment of Desmosomal Adhesion.,2026,10.1002/biof.70161,https://pubmed.ncbi.nlm.nih.gov/42902457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,41734070,Human oncogenic herpesvirus latency proteins activate NEK2 to promote chromosomal instability and tumorigenesis.,2026,10.1073/pnas.2535073123,https://pubmed.ncbi.nlm.nih.gov/41734070/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,42733978,NEK2 is involved in the mediation of the effects of LPS in endothelial cells.,2026,10.1080/21688370.2026.2732890,https://pubmed.ncbi.nlm.nih.gov/42733978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,42918762,NEK2-AURKA axis drives ubiquitin-dependent IFT88 degradation to suppress ciliogenesis and promote basal-type bladder cancer.,2026,10.1038/s41419-026-09203-0,https://pubmed.ncbi.nlm.nih.gov/42918762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,42708803,Targeting the HEC1-NEK2 Axis Suppresses DLBCL Progression and Overcomes Vincristine Resistance.,2026,10.1158/1535-7163.mct-25-1503,https://pubmed.ncbi.nlm.nih.gov/42708803/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,41664181,Disruption of the NDC80-Nek2 axis suppresses glioblastoma stemness and enhances therapeutic efficacy.,2026,10.1186/s12967-026-07829-4,https://pubmed.ncbi.nlm.nih.gov/41664181/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,42799399,Integrated Systems Toxicology Analysis and Molecular Dynamics Study Reveal the Potential Mechanism by which Benzo[a]pyrene Contributes to Depression in Lung Adenocarcinoma via RNASE1 Upregulation.,2026,10.1021/acsomega.6c04956,https://pubmed.ncbi.nlm.nih.gov/42799399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,42369548,Exploring the potential of gut microbiota metabolites in the treatment of endometriosis through network pharmacology and Mendelian randomization.,2026,10.3389/fmicb.2026.1733323,https://pubmed.ncbi.nlm.nih.gov/42369548/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,40481479,NEK2 regulates B cell function and the severity of experimental autoimmune encephalomyelitis.,2025,10.1186/s12974-025-03472-w,https://pubmed.ncbi.nlm.nih.gov/40481479/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,41577570,Role of Nek2 and Hec1 in HTLV-1-Infected T-Cell Lines.,2026,10.1111/ejh.70124,https://pubmed.ncbi.nlm.nih.gov/41577570/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,39963019,NEK2 Control of Esophageal Squamous Cell Carcinoma Growth Based on Circadian Oscillation.,2025,10.1111/cas.16461,https://pubmed.ncbi.nlm.nih.gov/39963019/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,41727445,Comprehensive analysis of mitophagy-related genes reveals prognostic signatures in breast cancer: based on immune landscapes and treatment target predict.,2026,10.3389/fimmu.2026.1740830,https://pubmed.ncbi.nlm.nih.gov/41727445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,41772945,GNL3 Orchestrates AR Transcriptional Programs to Drive Castration-Resistant Prostate Cancer and Immune Evasion.,2026,10.1002/advs.202516411,https://pubmed.ncbi.nlm.nih.gov/41772945/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,40397754,Sphingolipid synthesis in tumor-associated macrophages confers immunotherapy resistance in hepatocellular carcinoma.,2025,10.1126/sciadv.adv0558,https://pubmed.ncbi.nlm.nih.gov/40397754/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,41456821,NIMA-related Kinase 2: A master regulator of mitotic fidelity and chromosomal instability in cancer: From mechanisms to therapeutic targeting.,2026,10.1016/j.bbcan.2025.189523,https://pubmed.ncbi.nlm.nih.gov/41456821/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,39505744,NEK2 is a potential pan-cancer biomarker and immunotherapy target.,2024,10.1007/s12672-024-01519-7,https://pubmed.ncbi.nlm.nih.gov/39505744/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,40076620,"Targeting NEK Kinases in Gastrointestinal Cancers: Insights into Gene Expression, Function, and Inhibitors.",2025,10.3390/ijms26051992,https://pubmed.ncbi.nlm.nih.gov/40076620/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,38758909,Function of NEK2 in clear cell renal cell carcinoma and its effect on the tumor microenvironment.,2024,10.1097/md.0000000000037939,https://pubmed.ncbi.nlm.nih.gov/38758909/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,42720478,Structure-Based Design of First Ndc80 Loop-Targeting Peptide Disrupting Ndc80-Nuf2 Interaction for Hepatocellular Carcinoma Therapy.,2026,10.1021/acs.jmedchem.6c01876,https://pubmed.ncbi.nlm.nih.gov/42720478/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,40259950,NEK2 inhibition alleviates lipopolysaccharide-induced endothelial injury.,2025,10.1016/j.aspetd.2025.100002,https://pubmed.ncbi.nlm.nih.gov/40259950/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,42328663,Integrative bioinformatics informed by network toxicology and machine learning elucidates the carcinogenic mechanisms of benzo[a]pyrene-induced breast cancer.,2026,10.7717/peerj.21346,https://pubmed.ncbi.nlm.nih.gov/42328663/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,39181803,Role of NEK2 in tumorigenesis and tumor progression.,2025,10.1016/j.molmed.2024.07.013,https://pubmed.ncbi.nlm.nih.gov/39181803/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,15659832,Alternatively spliced protein variants as potential therapeutic targets for male infertility and contraception.,2004,10.1196/annals.1329.059,https://pubmed.ncbi.nlm.nih.gov/15659832/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEK2,ENSG00000117650,Unsafe,11742531,Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosis.,2002,10.1042/0264-6021:3610077,https://pubmed.ncbi.nlm.nih.gov/11742531/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEMP2,ENSG00000189362,Unsafe,39679859,Genetic Architecture of Idiopathic Inflammatory Myopathies From Meta-Analyses.,2025,10.1002/art.43088,https://pubmed.ncbi.nlm.nih.gov/39679859/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEMP2,ENSG00000189362,Unsafe,36399942,DNMT3A-mediated high expression of circ_0057504 promotes benzo[a]pyrene-induced DNA damage via the NONO-SFPQ complex in human bronchial epithelial cells.,2022,10.1016/j.envint.2022.107627,https://pubmed.ncbi.nlm.nih.gov/36399942/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEMP2,ENSG00000189362,Unsafe,27350576,A Group of Weakly Bound to Neurons Extracellular Metallopeptidases (NEMPs).,2016,10.1007/s11064-016-1979-9,https://pubmed.ncbi.nlm.nih.gov/27350576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEMP2,ENSG00000189362,Unsafe,20648054,"Hemizygous deletion of COL3A1, COL5A2, and MSTN causes a complex phenotype with aortic dissection: a lesson for and from true haploinsufficiency.",2010,10.1038/ejhg.2010.105,https://pubmed.ncbi.nlm.nih.gov/20648054/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,42502106,Vitamin a modulates neurogenesis-associated pathways and cholinergic signaling in Alzheimer's disease: potential role of reactive astrocytes via NGN2/SOX-11 and SIRT-1.,2026,10.1038/s41598-026-55386-z,https://pubmed.ncbi.nlm.nih.gov/42502106/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,42401982,PBAE nanoparticle-mediated delivery of ASCL1 and NGN2 genes for astroglia-to-neuron reprogramming to remodel glial scar for spinal cord injury repair.,2026,10.1186/s13287-026-05159-2,https://pubmed.ncbi.nlm.nih.gov/42401982/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,42722703,TRANsCre-DIONE transdifferentiates scar-forming reactive astrocytes into functional motor neurons.,2026,10.1038/s12276-026-01815-y,https://pubmed.ncbi.nlm.nih.gov/42722703/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,41588007,Olig2 acts as an inducible barrier to in vivo astrocyte-to-neuron conversion.,2026,10.1038/s41467-026-68869-4,https://pubmed.ncbi.nlm.nih.gov/41588007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,41823327,Maternal obesity induces activator protein 1-mediated inflammatory response to impair embryonic neurogenesis.,2026,10.1113/jp289326,https://pubmed.ncbi.nlm.nih.gov/41823327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,42309337,Optimizing NGN2 Dosage Enhances the Neuronal Enrichment of iPSC-Derived Neuronal Cultures.,2026,10.1016/j.mcpro.2026.101604,https://pubmed.ncbi.nlm.nih.gov/42309337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,41589677,Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors.,2026,10.7554/elife.100340,https://pubmed.ncbi.nlm.nih.gov/41589677/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,42081393,"Rapid, Growth Factor-Reduced Induction of Functional Neurons from hiPSCs.",2026,10.1159/000552324,https://pubmed.ncbi.nlm.nih.gov/42081393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,41632409,Early Reprogramming Intermediates Enable Direct Neuronal Conversion Via NGN2.,2026,10.1007/s12031-025-02460-2,https://pubmed.ncbi.nlm.nih.gov/41632409/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,42103698,Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons.,2026,10.1111/acel.70494,https://pubmed.ncbi.nlm.nih.gov/42103698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,42630431,"Direct neuronal reprogramming for neurological diseases: applications, translational Challenges, and future directions.",2026,10.3389/fnins.2026.1889859,https://pubmed.ncbi.nlm.nih.gov/42630431/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,41417018,T3 enhances neuronal activity in an induced pluripotent stem cell derived model of early human brain development.,2026,10.1530/etj-25-0193,https://pubmed.ncbi.nlm.nih.gov/41417018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,41572325,Fecal microbiota transplantation promotes Wnt3a-mediated hippocampal neurogenesis in a rat model of chronic cerebral hypoperfusion.,2026,10.1186/s12967-025-07631-8,https://pubmed.ncbi.nlm.nih.gov/41572325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,42748925,"Self-amplifying RNA enables rapid, durable, integration-free programming of hiPSCs.",2026,10.1016/j.crmeth.2026.101602,https://pubmed.ncbi.nlm.nih.gov/42748925/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,42624951,Comparative analysis of surface coatings for human neural co-cultures identifies fibronectin as a robust MEA substrate.,2026,10.1038/s41598-026-67677-6,https://pubmed.ncbi.nlm.nih.gov/42624951/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,42278126,Construction of TF-lncRNA-miRNA-mRNA Regulatory Network Affecting Sow Reproduction Based on QTLs for Corpus Luteum Number.,2026,10.3390/ani16111693,https://pubmed.ncbi.nlm.nih.gov/42278126/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,40650995,Human cortical neurons rapidly generated by embryonic stem cell programming integrate into the stroke-injured rat cortex.,2025,10.1093/stmcls/sxaf049,https://pubmed.ncbi.nlm.nih.gov/40650995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,39390804,SOXC Enhances NGN2-Mediated Reprogramming of Glioblastoma Cells Into Neuron-Like Cells by Modulating RhoA and RAC1/CDC42 Pathway Activity.,2024,10.1111/cns.70075,https://pubmed.ncbi.nlm.nih.gov/39390804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,41265444,Ngn2 and Isl1-mediated astrocyte-to-neuron conversion in vivo promotes functional recovery after spinal cord injury.,2025,10.1016/j.xcrm.2025.102462,https://pubmed.ncbi.nlm.nih.gov/41265444/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,41526180,Independent control of neurogenesis and dorsoventral patterning by NKX2-2.,2026,10.1101/gad.352886.125,https://pubmed.ncbi.nlm.nih.gov/41526180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,42448272,Developmental neurotoxic effects of organophosphate flame retardants (OPFRs) across different life stages and the central role of pioneer transcription factors Neurog2/Ascl1 during the embryonic period.,2026,10.1016/j.envpol.2026.128679,https://pubmed.ncbi.nlm.nih.gov/42448272/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,40301542,A novel role for Neurog2 in MYCN driven neuroendocrine plasticity of prostate cancer.,2025,10.1038/s41388-025-03413-0,https://pubmed.ncbi.nlm.nih.gov/40301542/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,42777717,"CRISPR-associated enzymes are mislocalized to the cytoplasm in iPSC-derived neurons, resulting in KRAB(KOX1)-specific degradation.",2026,10.1016/j.cels.2026.101737,https://pubmed.ncbi.nlm.nih.gov/42777717/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,40086434,Proliferation history and transcription factor levels drive direct conversion to motor neurons.,2025,10.1016/j.cels.2025.101205,https://pubmed.ncbi.nlm.nih.gov/40086434/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,41025098,Exercise combined with induced pluripotent stem cells enhances the Wnt1-Lmx1a loop in the midbrain of Parkinsonian mice to alleviate Parkinsonian symptoms.,2025,10.4252/wjsc.v17.i9.109330,https://pubmed.ncbi.nlm.nih.gov/41025098/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,40022736,Protocol for generating NGN2 iPSC lines and large-scale human neuron production.,2025,10.1016/j.xpro.2025.103654,https://pubmed.ncbi.nlm.nih.gov/40022736/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,41742306,Forward programming of human pluripotent stem cells to generate glutamatergic and GABAergic neurons in a tri-culture model with astrocytes.,2026,10.1186/s13287-026-04917-6,https://pubmed.ncbi.nlm.nih.gov/41742306/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,42568588,Optimization of a neuron-microglia co-culture model to explore cell-to-cell interaction dynamics.,2026,10.3389/fimmu.2026.1850795,https://pubmed.ncbi.nlm.nih.gov/42568588/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,40913769,Chemogenetic tuning reveals optimal MAPK signaling for cell-fate programming.,2025,10.1016/j.celrep.2025.116226,https://pubmed.ncbi.nlm.nih.gov/40913769/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,41467429,Therapeutic potential of astrocyte transdifferentiated neurons.,2026,10.4103/nrr.nrr-d-25-00554,https://pubmed.ncbi.nlm.nih.gov/41467429/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,41324907,Transcriptional signature of induced neurons differentiates virologically suppressed people with HIV from people without HIV.,2026,10.1172/jci.insight.190445,https://pubmed.ncbi.nlm.nih.gov/41324907/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEUROG2,ENSG00000178403,Unsafe,40527961,Drug treatment alters performance in a neural microphysiological system of information processing.,2025,10.1038/s42003-025-08194-6,https://pubmed.ncbi.nlm.nih.gov/40527961/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,42074566,A 350 kb &lt;i&gt;NEXMIF&lt;/i&gt; Microdeletion Identified by Chromosomal Microarray in an Adult Patient with Jeavons Syndrome.,2026,10.3390/genes17040448,https://pubmed.ncbi.nlm.nih.gov/42074566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,40141841,&lt;i&gt;KIAA2022/NEXMIF&lt;/i&gt; c.1882C&gt;T (p.Arg628*) Variant in a Romanian Patient with Neurodevelopmental Disorders and Epilepsy: A Case Report and Systematic Review.,2025,10.3390/life15030497,https://pubmed.ncbi.nlm.nih.gov/40141841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,41053001,"Restoration of NEXMIF expression rescues abnormalities in gene transcription, neuron maturation and autistic-like behaviors in Nexmif knockout mice.",2025,10.1038/s41398-025-03537-7,https://pubmed.ncbi.nlm.nih.gov/41053001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,41728594,Intellectual disorder type 98 caused by a novel NEXMIF variant: a case report and literature review.,2026,10.3389/fmed.2026.1757682,https://pubmed.ncbi.nlm.nih.gov/41728594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,40606839,NEXMIF overexpression is associated with autism-like behaviors and alterations in dendritic arborization and spine formation in mice.,2025,10.3389/fnins.2025.1556570,https://pubmed.ncbi.nlm.nih.gov/40606839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,42880131,Identification of biomarkers related to lymph node metastasis and prognosis in thyroid cancer based on integrated bioinformatics exploration.,2026,10.1016/j.clinsp.2026.101201,https://pubmed.ncbi.nlm.nih.gov/42880131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,39129698,NEXMIF Combined with KIDINS220 Gene Mutation Caused Neurodevelopmental Disorder and Epilepsy: One Case Report.,2024,10.62641/aep.v52i4.1625,https://pubmed.ncbi.nlm.nih.gov/39129698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,38322873,"Heterozygous Nexmif female mice demonstrate mosaic NEXMIF expression, autism-like behaviors, and abnormalities in dendritic arborization and synaptogenesis.",2024,10.1016/j.heliyon.2024.e24703,https://pubmed.ncbi.nlm.nih.gov/38322873/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,40171791,Gonadal mosaicism and paradoxical phenotype in &lt;i&gt;NEXMIF&lt;/i&gt; encephalopathy: a case report of two siblings.,2025,10.1007/s12041-025-01496-y,https://pubmed.ncbi.nlm.nih.gov/40171791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,35970867,Loss of Nexmif results in the expression of phenotypic variability and loss of genomic integrity.,2022,10.1038/s41598-022-17845-1,https://pubmed.ncbi.nlm.nih.gov/35970867/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,38946365,[Clinical and genetic analysis of a child with X-linked intellectual developmental disorder due to a novel variant of NEXMIF gene].,2024,10.3760/cma.j.cn511374-20230530-00325,https://pubmed.ncbi.nlm.nih.gov/38946365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,42112912,Genetic landscape of patients with atypical absence status epilepticus: A systematic review.,2026,10.1002/epi4.70275,https://pubmed.ncbi.nlm.nih.gov/42112912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,37965217,The autism spectrum disorder risk gene NEXMIF over-synchronizes hippocampal CA1 network and alters neuronal coding.,2023,10.3389/fnins.2023.1277501,https://pubmed.ncbi.nlm.nih.gov/37965217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,42037703,Genotype mutations and phenotypes of 30 cases with epilepsy related to fever sensitivity in children.,2026,10.3389/fneur.2026.1766799,https://pubmed.ncbi.nlm.nih.gov/42037703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,39317145,Profiling of B cells and their subsets by whole blood gene expression analysis versus flow cytometry in multiple sclerosis.,2024,10.1016/j.msard.2024.105898,https://pubmed.ncbi.nlm.nih.gov/39317145/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,40286787,"Defining molecular signatures of the solid/pseudopapillary and pseudoglandular patterns in so-called ""solid-tubulocystic intrahepatic cholangiocarcinoma vs. NIPBL::NACC1 fusion hepatic carcinoma"".",2025,10.1016/j.prp.2025.155962,https://pubmed.ncbi.nlm.nih.gov/40286787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,37643945,NEXMIF variants are associated with epilepsy with or without intellectual disability.,2024,10.1016/j.seizure.2023.08.012,https://pubmed.ncbi.nlm.nih.gov/37643945/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,37427056,NEXMIF pathogenic variant in a female child with epilepsy and multiple organ failure: a case report.,2023,10.21037/tp-22-435,https://pubmed.ncbi.nlm.nih.gov/37427056/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,38612920,X-Linked Epilepsies: A Narrative Review.,2024,10.3390/ijms25074110,https://pubmed.ncbi.nlm.nih.gov/38612920/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,33224018,Clonazepam as an Effective Treatment for Epilepsy in a Female Patient with NEXMIF Mutation: Case Report.,2020,10.1159/000510172,https://pubmed.ncbi.nlm.nih.gov/33224018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,40429983,"Impact of Genetic Testing Using Gene Panels, Exomes, and Genome Sequencing in Romanian Children with Epilepsy.",2025,10.3390/ijms26104843,https://pubmed.ncbi.nlm.nih.gov/40429983/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,31704787,"NEXMIF/KIDLIA Knock-out Mouse Demonstrates Autism-Like Behaviors, Memory Deficits, and Impairments in Synapse Formation and Function.",2020,10.1523/jneurosci.0222-19.2019,https://pubmed.ncbi.nlm.nih.gov/31704787/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NEXMIF,ENSG00000050030,Unsafe,15466006,Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males.,2004,10.1136/jmg.2004.021626,https://pubmed.ncbi.nlm.nih.gov/15466006/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,41926771,Identification of CD74-Positive Antigen-Presenting Glioma Cells in Primary Human Tumors and Murine Models of NF1 High-Grade Glioma.,2026,10.1158/1535-7163.mct-25-1215,https://pubmed.ncbi.nlm.nih.gov/41926771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42529156,"Case Report: Multifocal plexiform neurofibromas presenting as a paratesticular ""string-of-beads"" mass in a 7-year-old boy with neurofibromatosis type 1.",2026,10.3389/fped.2026.1900387,https://pubmed.ncbi.nlm.nih.gov/42529156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42428031,Metastatic Testicular Germ Cell Tumor in a Patient With Neurofibromatosis Type 1: Treatment With Trametinib Based on &lt;i&gt;NF1&lt;/i&gt; Gene Mutation.,2026,10.1002/iju5.70223,https://pubmed.ncbi.nlm.nih.gov/42428031/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42608490,Comprehensive mapping of Neurofibromin (NF1) expression in developing mouse brain.,2026,10.1007/s00429-026-03173-x,https://pubmed.ncbi.nlm.nih.gov/42608490/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,41683605,Neurofibromin 1 (&lt;i&gt;NF1&lt;/i&gt;) Splicing Mutation c.61-2A&gt;G: From Aberrant mRNA Processing to Therapeutic Implications In Silico.,2026,10.3390/ijms27031177,https://pubmed.ncbi.nlm.nih.gov/41683605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42719078,Case Report: Clinical and molecular genetic analysis of a patient with coexisting complete androgen insensitivity syndrome and neurofibromatosis type 1 and 15pstk + polymorphism.,2026,10.3389/fped.2026.1919358,https://pubmed.ncbi.nlm.nih.gov/42719078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42683315,"The ERK MAPK pathway in mesenchymal glioblastoma: tumorigenesis, microenvironmental reprogramming, and the therapeutic promise of RAS(ON) multi-selective inhibition.",2026,10.3389/fnmol.2026.1857885,https://pubmed.ncbi.nlm.nih.gov/42683315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42656761,Case Report: A somatic &lt;i&gt;NF1&lt;/i&gt; splice-altering variant identified in lesional tissue in peripheral blood-negative segmental facial neurofibromatosis.,2026,10.3389/fnins.2026.1887523,https://pubmed.ncbi.nlm.nih.gov/42656761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42627929,NF1 Leucine Rich Domain-Derived Extracellular Vesicles Remodel the Glioblastoma Immune Microenvironment via an ADAM17-Associated Inflammatory Program.,2026,10.1002/jev2.70355,https://pubmed.ncbi.nlm.nih.gov/42627929/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42895117,"PDE4DIP/Myomegalin as a Golgi-Centrosome Scaffold in Compartmentalized Signaling, Microtubule Organization, and Disease-Associated Pathway Remodeling.",2026,10.1002/cbf.70325,https://pubmed.ncbi.nlm.nih.gov/42895117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42658051,Radial Reconstruction With Fibular Free Flap Using CAD-CAM and Virtual Surgical Planning in Pediatric Pseudoarthrosis due to Neurofibromatosis Type 1: A Case Report and Literature Review.,2026,10.1002/micr.70285,https://pubmed.ncbi.nlm.nih.gov/42658051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42638681,Case Report: Twisted subbasal corneal nerve fibers in a case of neurofibromatosis type 1.,2026,10.3389/fnins.2026.1874737,https://pubmed.ncbi.nlm.nih.gov/42638681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,40812791,Alternative Splicing of Exon 23a in Neurofibromatosis Type 1 Pre-mRNA: Its Contribution to the Protein Structure and Function of Neurofibromin.,2025,10.1002/wrna.70021,https://pubmed.ncbi.nlm.nih.gov/40812791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42520478,Spatial proteomic profiling reveals an association between NF1-Ras/Raf/MEK signaling and immune cell infiltration in locally advanced triple-negative breast cancer.,2026,10.1016/j.tranon.2026.102934,https://pubmed.ncbi.nlm.nih.gov/42520478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42428777,Ruptured A3 segment aneurysm in a patient with neurofibromatosis type 1: a case report and literature review.,2026,10.3389/fsurg.2026.1825953,https://pubmed.ncbi.nlm.nih.gov/42428777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,41987183,Genetic and non-genetic factors influencing phenotypic variability in neurofibromatosis type 1.,2026,10.1186/s13023-026-04334-1,https://pubmed.ncbi.nlm.nih.gov/41987183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42292757,Molecular Genetic Confirmation of Jaffe-Campanacci Syndrome: A Case Report of the Third Identified Pathogenic &lt;i&gt;NF1&lt;/i&gt; Variant.,2026,10.1159/000551849,https://pubmed.ncbi.nlm.nih.gov/42292757/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,41374990,Neurofibromatosis Type 1: Genetic Mechanisms and Advances in Therapeutic Innovation.,2025,10.3390/cancers17233788,https://pubmed.ncbi.nlm.nih.gov/41374990/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42493427,Novel Germline ELP1 Splice-Acceptor Variant in NF1-Negative Optic Pathway Glioma: Expanding the Clinical Spectrum Associated With ELP1 Variation.,2026,10.1111/cge.70219,https://pubmed.ncbi.nlm.nih.gov/42493427/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42791538,Genotype-driven tumor ecosystems drive immune evasion and immunotherapy resistance in melanoma.,2026,10.1186/s12943-026-02781-9,https://pubmed.ncbi.nlm.nih.gov/42791538/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42797500,Therapeutic Resistance in Melanoma: Molecular Mechanisms and Emerging Pharmaceutical Strategies.,2026,10.3390/ph19091455,https://pubmed.ncbi.nlm.nih.gov/42797500/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42794996,"Contemporary Multimodal Management of Cutaneous Malignancies: Surgery, Radiotherapy, Systemic Therapy, Molecular Targeting and Immunotherapy.",2026,10.3390/cancers18183029,https://pubmed.ncbi.nlm.nih.gov/42794996/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42588680,New Approaches to Clinical Trials for Rare Diseases: Decentralized Trial Design for Neurofibromatosis Type 1 and Schwannomatosis.,2026,10.3390/cancers18152463,https://pubmed.ncbi.nlm.nih.gov/42588680/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42872421,Targeted pharmacotherapy of NF1-associated plexiform neurofibromas: current evidence and future perspectives.,2026,10.1080/14656566.2026.2750237,https://pubmed.ncbi.nlm.nih.gov/42872421/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42837360,"Efficacy and safety of MEK inhibitors for NF1-associated symptomatic, inoperable plexiform neurofibromas: A systematic review and meta-analysis.",2026,10.1371/journal.pone.0359957,https://pubmed.ncbi.nlm.nih.gov/42837360/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,41492362,Melanoma: Pathogenesis and Targeted Therapy.,2026,10.1002/mco2.70566,https://pubmed.ncbi.nlm.nih.gov/41492362/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42059002,MEK inhibitors for neurofibromatosis type 1-associated central and peripheral nervous system tumors.,2026,10.1093/noajnl/vdae223,https://pubmed.ncbi.nlm.nih.gov/42059002/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42276973,Selumetinib as a Target Therapy in Progressive Paediatric Low-Grade Gliomas-Case Series (pLGG).,2026,10.1111/jpc.70455,https://pubmed.ncbi.nlm.nih.gov/42276973/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,41374983,Challenges and Progress for Treatment of Malignant Peripheral Nerve Sheath Tumors in the Context of Recent Successes for Sarcoma Therapy.,2025,10.3390/cancers17233781,https://pubmed.ncbi.nlm.nih.gov/41374983/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42151367,Lorlatinib monotherapy or combination therapy in anaplastic lymphoma kinase-driven high-risk neuroblastoma.,2026,10.1038/s41698-026-01487-x,https://pubmed.ncbi.nlm.nih.gov/42151367/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,41898726,Emerging Molecular Insights and Therapeutic Directions in Neurofibromatosis Type 1 and NF2-Related Schwannomatosis.,2026,10.3390/ijms27062867,https://pubmed.ncbi.nlm.nih.gov/41898726/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42467350,Disease Stabilization with MEK Inhibitors in NF1-Associated Plexiform Neurofibromas: A Systematic Review and Meta-Analysis with Subgroup Analyses by Age and Study Design.,2026,10.1007/s40263-026-01316-6,https://pubmed.ncbi.nlm.nih.gov/42467350/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42827732,Managing skin-related adverse events during mirdametinib treatment for NF1-PNs: expert guidance from the ReNeu trial.,2026,10.3389/fonc.2026.1826735,https://pubmed.ncbi.nlm.nih.gov/42827732/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42155032,TRAM-01: A phase 2 study of trametinib for pediatric patients with neurofibromatosis type 1 and plexiform neurofibromas.,2026,10.1093/neuonc/noag112,https://pubmed.ncbi.nlm.nih.gov/42155032/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42266657,Exceptional response to everolimus in an NF1-deficient recurrent endometrioid adenocarcinoma: a case report.,2026,10.3389/fonc.2026.1828591,https://pubmed.ncbi.nlm.nih.gov/42266657/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42614357,MYC as a key target for melanoma therapy.,2026,10.3389/fcell.2026.1750941,https://pubmed.ncbi.nlm.nih.gov/42614357/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,41944918,A PIK3CA and NF1 expression-based prognostic signature derived from Mendelian randomization identifies causal immune-regulatory determinants of glioblastoma outcomes.,2026,10.1007/s12672-026-04658-1,https://pubmed.ncbi.nlm.nih.gov/41944918/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,42337518,"Characteristics, treatment patterns, healthcare resource use, and costs among adult patients diagnosed with neurofibromatosis type 1 and plexiform neurofibromas in the United States.",2026,10.1186/s12883-026-04868-8,https://pubmed.ncbi.nlm.nih.gov/42337518/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NF1,ENSG00000196712,Unsafe,8417346,"A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity.",1993,10.1128/mcb.13.1.487-495.1993,https://pubmed.ncbi.nlm.nih.gov/8417346/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,42690170,Base editing reversal of radiation sensitivity in NHEJ1 immunodeficiency.,2026,10.70962/jhi.20260068,https://pubmed.ncbi.nlm.nih.gov/42690170/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,42055551,HSF1 and YTHDC1 enhance DNA repair under heat stress by promoting repair-associated gene expression.,2026,10.1093/nar/gkag418,https://pubmed.ncbi.nlm.nih.gov/42055551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,42151760,A heterozygous deletion and inversion at the NHEJ1‑IHH locus associated with shank length in Yunlong short-leg chicken.,2026,10.1186/s12864-026-12943-0,https://pubmed.ncbi.nlm.nih.gov/42151760/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,42328524,Vitiligo like depigmentation in a patient with NHEJ1 deficiency related radiosensitive SCID: A case report.,2026,10.1016/j.jdcr.2026.05.010,https://pubmed.ncbi.nlm.nih.gov/42328524/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,42536752,A &lt;i&gt;NHEJ1&lt;/i&gt; mutator allele influencing germline mutation rates sex-specifically in humans.,2026,10.1126/sciadv.aed2571,https://pubmed.ncbi.nlm.nih.gov/42536752/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,42638394,Successful Therapy of CNS Tuberculosis With Granulomatous Inflammation in Immunodeficiency.,2026,10.1177/00099228261474403,https://pubmed.ncbi.nlm.nih.gov/42638394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,41225329,Expanding the clinical spectrum of Cernunnos/XLF deficiency: a literature review of a rare cause of severe combined immunodeficiency including a novel case.,2025,10.1186/s12865-025-00774-9,https://pubmed.ncbi.nlm.nih.gov/41225329/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,39836852,Severe immunodeficiency spectrum associated with NHEJ1 gene mutation: Cernunnos/XLF deficiency,2024,10.7705/biomedica.7414,https://pubmed.ncbi.nlm.nih.gov/39836852/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,41963310,"Berry-derived gold nanoparticles induce integrated ROS-mediated apoptosis, immune modulation, and transcriptomic remodeling in 4T1 triple-negative cancer cells.",2026,10.1038/s41420-026-03023-z,https://pubmed.ncbi.nlm.nih.gov/41963310/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,40428296,Analysis of Selected Eye Disorders in a Group of Predisposed Breeds of Dogs: Molecular Diagnostics of Collie Eye Anomaly and Progressive Retinal Atrophy.,2025,10.3390/genes16050474,https://pubmed.ncbi.nlm.nih.gov/40428296/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,42283036,Case Report: A case series of using whole exome sequencing to detect novel variants in Vietnamese patients with inborn errors of immunity.,2026,10.3389/fgene.2026.1818952,https://pubmed.ncbi.nlm.nih.gov/42283036/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,40047910,Genetic variants in NHEJ1 and related DNA repair disorders: insights into phenotypic heterogeneity and links to hypoplastic myelodysplastic syndromes and familial hematological malignancies susceptibility.,2025,10.1007/s00277-025-06257-6,https://pubmed.ncbi.nlm.nih.gov/40047910/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,42419216,Sex chromosome-targeted Cas9 knock-in and functional validation in chicken primordial germ cells.,2026,10.1016/j.psj.2026.107384,https://pubmed.ncbi.nlm.nih.gov/42419216/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,37667001,Comparative single-cell transcriptomic analysis of primate brains highlights human-specific regulatory evolution.,2023,10.1038/s41559-023-02186-7,https://pubmed.ncbi.nlm.nih.gov/37667001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,37580330,IHH enhancer variant within neighboring NHEJ1 intron causes microphthalmia anophthalmia and coloboma.,2023,10.1038/s41525-023-00364-x,https://pubmed.ncbi.nlm.nih.gov/37580330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,39773758,A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children.,2025,10.1186/s13148-024-01782-z,https://pubmed.ncbi.nlm.nih.gov/39773758/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,35967585,"Novel NHEJ1 pathogenic variant linked to severe combined immunodeficiency, microcephaly, and abnormal T and B cell receptor repertoires.",2022,10.3389/fped.2022.883173,https://pubmed.ncbi.nlm.nih.gov/35967585/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,35369581,A novel multiplex polymerase chain reaction assay for the genotypic survey of the non-homologous end-joining factor 1 gene associated with Collie eye anomaly in Thailand.,2022,10.14202/vetworld.2022.132-139,https://pubmed.ncbi.nlm.nih.gov/35369581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,35127102,Genotypic and allelic frequency of a mutation in the NHEJ1 gene associated with collie eye anomaly in dogs in Italy.,2022,10.1002/vro2.26,https://pubmed.ncbi.nlm.nih.gov/35127102/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,35812385,Case Report: Refractory Cytopenia With a Switch From a Transient Monosomy 7 to a Disease-Ameliorating del(20q) in a NHEJ1-Deficient Long-term Survivor.,2022,10.3389/fimmu.2022.869047,https://pubmed.ncbi.nlm.nih.gov/35812385/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,37842439,Haploidentical Transplant in Radiosensitive Severe Combined Immunodeficiency Disease.,2023,10.7759/cureus.45159,https://pubmed.ncbi.nlm.nih.gov/37842439/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,40457861,Centralized rapid genetic diagnosis of combined immunodeficiency in Japan.,2025,10.1111/ped.70085,https://pubmed.ncbi.nlm.nih.gov/40457861/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,39200230,Genetic and Epigenetic Biomarkers Associated with Early Relapse in Pediatric Acute Lymphoblastic Leukemia: A Focused Bioinformatics Study on DNA-Repair Genes.,2024,10.3390/biomedicines12081766,https://pubmed.ncbi.nlm.nih.gov/39200230/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,34519267,"An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development.",2021,10.7554/elife.69353,https://pubmed.ncbi.nlm.nih.gov/34519267/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,30898087,An immunocompetent patient with a nonsense mutation in NHEJ1 gene.,2019,10.1186/s12881-019-0784-0,https://pubmed.ncbi.nlm.nih.gov/30898087/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,30666249,Extreme Phenotypes With Identical Mutations: Two Patients With Same Non-sense NHEJ1 Homozygous Mutation.,2018,10.3389/fimmu.2018.02959,https://pubmed.ncbi.nlm.nih.gov/30666249/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,35656589,Cernunnos defect in an Iranian patient with T- B+ NK+ severe combined immunodeficiency: A case report and review of the literature.,2022,10.1002/mgg3.1990,https://pubmed.ncbi.nlm.nih.gov/35656589/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,33628209,"Clinical, Immunological, and Molecular Features of Severe Combined Immune Deficiency: A Multi-Institutional Experience From India.",2020,10.3389/fimmu.2020.619146,https://pubmed.ncbi.nlm.nih.gov/33628209/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,35172473,Correlation-based and feature-driven mutation signature analyses to identify genetic features associated with DNA mutagenic processes in cancer genomes.,2021,10.5808/gi.21047,https://pubmed.ncbi.nlm.nih.gov/35172473/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,35251167,DNA Damage Response Genes in Osteosarcoma.,2021,10.1155/2021/9365953,https://pubmed.ncbi.nlm.nih.gov/35251167/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,30546078,Genomic and transcriptomic landscapes of Epstein-Barr virus in extranodal natural killer T-cell lymphoma.,2019,10.1038/s41375-018-0324-5,https://pubmed.ncbi.nlm.nih.gov/30546078/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NHEJ1,ENSG00000187736,Unsafe,16439204,"Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.",2006,10.1016/j.cell.2005.12.030,https://pubmed.ncbi.nlm.nih.gov/16439204/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPD1,ENSG00000150776,Unsafe,37936456,Systematic Analysis of Tumor Stem Cell-related Gene Characteristics to Predict the PD-L1 Immunotherapy and Prognosis of Gastric Cancer.,2024,10.2174/0109298673278775231101064235,https://pubmed.ncbi.nlm.nih.gov/37936456/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPD1,ENSG00000150776,Unsafe,20310044,Novel germline SDHD deletion associated with an unusual sympathetic head and neck paraganglioma.,2011,10.1002/hed.21384,https://pubmed.ncbi.nlm.nih.gov/20310044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPL,ENSG00000189134,Unsafe,41032616,&lt;i&gt;Nkapl&lt;/i&gt; deletion drives cognitive deficits through mPFC interneuron dysfunction in a mouse model of schizophrenia.,2025,10.1126/sciadv.adv4779,https://pubmed.ncbi.nlm.nih.gov/41032616/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPL,ENSG00000189134,Unsafe,39824811,NKAPL facilitates transcription pause-release and bridges elongation to initiation during meiosis exit.,2025,10.1038/s41467-024-55579-y,https://pubmed.ncbi.nlm.nih.gov/39824811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPL,ENSG00000189134,Unsafe,40605974,NKAPL suppresses NSCLC progression by enhancing the protein stability of TRIM21 and further inhibiting the NF-κB signaling pathway.,2025,10.1016/j.gendis.2025.101598,https://pubmed.ncbi.nlm.nih.gov/40605974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPL,ENSG00000189134,Unsafe,40724805,Unveiling Epigenetic Regulatory Elements Associated with Breast Cancer Development.,2025,10.3390/ijms26146558,https://pubmed.ncbi.nlm.nih.gov/40724805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPL,ENSG00000189134,Unsafe,35801084,Association of NKAPL rs1635 With Cognitive Function in Early-Onset Schizophrenia.,2022,10.3389/fgene.2022.941171,https://pubmed.ncbi.nlm.nih.gov/35801084/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPL,ENSG00000189134,Unsafe,41893917,DNA methylation signatures from peripheral blood revealed epigenetic alterations in Fanconi anemia.,2026,10.1007/s00439-026-02827-4,https://pubmed.ncbi.nlm.nih.gov/41893917/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPL,ENSG00000189134,Unsafe,38495498,Illuminating Shared Genetic Associations Between Oesophageal Carcinoma and Pulmonary Carcinoma Risk.,2024,10.7150/jca.92899,https://pubmed.ncbi.nlm.nih.gov/38495498/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPL,ENSG00000189134,Unsafe,25875095,A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis.,2015,10.1371/journal.pone.0124293,https://pubmed.ncbi.nlm.nih.gov/25875095/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPL,ENSG00000189134,Unsafe,32544280,"ABCC9, NKAPL, and TMEM132C are potential diagnostic and prognostic markers in triple-negative breast cancer.",2020,10.1002/cbin.11406,https://pubmed.ncbi.nlm.nih.gov/32544280/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPL,ENSG00000189134,Unsafe,29353445,Hypermethylation of NF-κB-Activating Protein-Like (NKAPL) Promoter in Hepatocellular Carcinoma Suppresses Its Expression and Predicts a Poor Prognosis.,2018,10.1007/s10620-018-4929-3,https://pubmed.ncbi.nlm.nih.gov/29353445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPL,ENSG00000189134,Unsafe,28427185,Transcriptional landscape of human cancers.,2017,10.18632/oncotarget.15837,https://pubmed.ncbi.nlm.nih.gov/28427185/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPL,ENSG00000189134,Unsafe,34569420,"Associations between infant sex and DNA methylation across umbilical cord blood, artery, and placenta samples.",2022,10.1080/15592294.2021.1985300,https://pubmed.ncbi.nlm.nih.gov/34569420/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPL,ENSG00000189134,Unsafe,28095483,Association between NF-κB Pathway Gene Variants and sICAM1 Levels in Taiwanese.,2017,10.1371/journal.pone.0169516,https://pubmed.ncbi.nlm.nih.gov/28095483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPL,ENSG00000189134,Unsafe,26297123,Further evidence supporting the association of NKAPL with schizophrenia.,2015,10.1016/j.neulet.2015.08.023,https://pubmed.ncbi.nlm.nih.gov/26297123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPL,ENSG00000189134,Unsafe,23223422,Identification of the NF-κB activating protein-like locus as a risk locus for rheumatoid arthritis.,2013,10.1136/annrheumdis-2012-202076,https://pubmed.ncbi.nlm.nih.gov/23223422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPL,ENSG00000189134,Unsafe,22037552,Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.,2011,10.1038/ng.979,https://pubmed.ncbi.nlm.nih.gov/22037552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKAPL,ENSG00000189134,Unsafe,23437227,Replication of association between schizophrenia and chromosome 6p21-6p22.1 polymorphisms in Chinese Han population.,2013,10.1371/journal.pone.0056732,https://pubmed.ncbi.nlm.nih.gov/23437227/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-8,ENSG00000136327,Unsafe,37492711,NK2 homeobox gene cluster: Functions and roles in human diseases.,2023,10.1016/j.gendis.2022.10.001,https://pubmed.ncbi.nlm.nih.gov/37492711/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-8,ENSG00000136327,Unsafe,35707355,NKX2-8/PTHrP Axis-Mediated Osteoclastogenesis and Bone Metastasis in Breast Cancer.,2022,10.3389/fonc.2022.907000,https://pubmed.ncbi.nlm.nih.gov/35707355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-8,ENSG00000136327,Unsafe,31047858,NKX2-8 deletion-induced reprogramming of fatty acid metabolism confers chemoresistance in epithelial ovarian cancer.,2019,10.1016/j.ebiom.2019.04.041,https://pubmed.ncbi.nlm.nih.gov/31047858/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-8,ENSG00000136327,Unsafe,32676340,Clinical impact of the lung tissue transcriptome in a teenager with multifocal invasive mucinous adenocarcinoma-a case report.,2020,10.21037/tlcr-20-177,https://pubmed.ncbi.nlm.nih.gov/32676340/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-8,ENSG00000136327,Unsafe,35041980,"RNA sequencing identifies genes reliant upon Ser26 in the zinc finger transcription factor, early growth response-1.",2022,10.1016/j.vph.2022.106952,https://pubmed.ncbi.nlm.nih.gov/35041980/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-8,ENSG00000136327,Unsafe,21148747,Both gene amplification and allelic loss occur at 14q13.3 in lung cancer.,2011,10.1158/1078-0432.ccr-10-1892,https://pubmed.ncbi.nlm.nih.gov/21148747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-8,ENSG00000136327,Unsafe,23874236,"Genome-wide association mapping in dogs enables identification of the homeobox gene, NKX2-8, as a genetic component of neural tube defects in humans.",2013,10.1371/journal.pgen.1003646,https://pubmed.ncbi.nlm.nih.gov/23874236/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-8,ENSG00000136327,Unsafe,23604637,Nkx2-8 downregulation promotes angiogenesis and activates NF-κB in esophageal cancer.,2013,10.1158/0008-5472.can-12-4028,https://pubmed.ncbi.nlm.nih.gov/23604637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-8,ENSG00000136327,Unsafe,19279207,"Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer.",2009,10.1073/pnas.0900827106,https://pubmed.ncbi.nlm.nih.gov/19279207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-8,ENSG00000136327,Unsafe,23674368,Methylation-specific digital karyotyping of HPV16E6E7-expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis.,2013,10.1002/path.4210,https://pubmed.ncbi.nlm.nih.gov/23674368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-8,ENSG00000136327,Unsafe,27810169,Conservatism and variability of gene expression profiles among homeologous transcription factors in Xenopus laevis.,2017,10.1016/j.ydbio.2016.09.017,https://pubmed.ncbi.nlm.nih.gov/27810169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-8,ENSG00000136327,Unsafe,21163872,One allele's loss is another's gain: alterations of NKX2-8 in non-small cell lung cancer.,2011,10.1158/1078-0432.ccr-10-3081,https://pubmed.ncbi.nlm.nih.gov/21163872/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-8,ENSG00000136327,Unsafe,24087792,Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage.,2014,10.1093/hmg/ddt453,https://pubmed.ncbi.nlm.nih.gov/24087792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-8,ENSG00000136327,Unsafe,27915271,Changes in renal gene expression associated with induced ochratoxicosis in chickens: activation and deactivation of transcripts after varying durations of exposure.,2017,10.3382/ps/pew419,https://pubmed.ncbi.nlm.nih.gov/27915271/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-8,ENSG00000136327,Unsafe,17925434,Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer.,2007,10.1073/pnas.0708286104,https://pubmed.ncbi.nlm.nih.gov/17925434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-8,ENSG00000136327,Unsafe,15467763,Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers.,2004,10.1038/sj.onc.1207783,https://pubmed.ncbi.nlm.nih.gov/15467763/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-8,ENSG00000136327,Unsafe,9232596,"Chicken NKx2-8, a novel homeobox gene expressed during early heart and foregut development.",1997,10.1016/s0925-4773(97)00044-0,https://pubmed.ncbi.nlm.nih.gov/9232596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NKX2-8,ENSG00000136327,Unsafe,9510029,BMP-2 induces ectopic expression of cardiac lineage markers and interferes with somite formation in chicken embryos.,1998,10.1016/s0925-4773(97)00186-x,https://pubmed.ncbi.nlm.nih.gov/9510029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,42168454,"Expression pattern, functional characteristics and prognostic significance of NLGN1 gene in nasopharyngeal carcinoma: a comprehensive multi-omics analysis.",2026,10.1007/s12672-026-05179-7,https://pubmed.ncbi.nlm.nih.gov/42168454/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,42778070,Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy by modulating the MeCP2/NLGN1 pathway.,2026,10.1016/j.brainresbull.2026.112135,https://pubmed.ncbi.nlm.nih.gov/42778070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,42549988,Deletion of neuroligins from astrocytes does not detectably alter synapse numbers or astrocyte cytoarchitecture by maturity.,2026,10.7554/elife.87589,https://pubmed.ncbi.nlm.nih.gov/42549988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,42063110,Integrative multi-omics profiling reveals distinct evolutionary and immunogenic features of brain oligometastasis in lung adenocarcinoma.,2026,10.1186/s13073-026-01664-4,https://pubmed.ncbi.nlm.nih.gov/42063110/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,42325569,SynCAR platform for capturing neuronal synaptic proteopathic seeds.,2026,10.1016/j.isci.2026.116362,https://pubmed.ncbi.nlm.nih.gov/42325569/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,42600301,Early-life exposure to polypropylene microplastics and DEHP induces ASD-relevant neurodevelopmental alterations involving mTOR-regulated autophagy impairment.,2026,10.1016/j.ecoenv.2026.120659,https://pubmed.ncbi.nlm.nih.gov/42600301/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,40424132,High-affinity detection of biotinylated endogenous neuroligin-1 at excitatory and inhibitory synapses using a tagged knock-in mouse.,2025,10.1073/pnas.2411669122,https://pubmed.ncbi.nlm.nih.gov/40424132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,41620473,Molecular signatures of resilience to Alzheimer's disease in neocortical layer 4 neurons.,2026,10.1038/s41467-026-68920-4,https://pubmed.ncbi.nlm.nih.gov/41620473/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,41570816,MDGA2 homozygous loss-of-function variants cause developmental and epileptic encephalopathy.,2026,10.1016/j.ajhg.2025.12.015,https://pubmed.ncbi.nlm.nih.gov/41570816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,41097092,Molecular Signatures of Schizophrenia and Insights into Potential Biological Convergence.,2025,10.3390/ijms26199830,https://pubmed.ncbi.nlm.nih.gov/41097092/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,40087687,Analysis of neurexin-neuroligin complexes supports an isoform-specific role for beta-neurexin-1 dysfunction in a mouse model of autism.,2025,10.1186/s13041-025-01183-0,https://pubmed.ncbi.nlm.nih.gov/40087687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,41687921,GR/HDAC2/synaptic complexes in hippocampal CA1 mediate the antidepressant effects of magnolol.,2026,10.1016/j.bj.2026.100961,https://pubmed.ncbi.nlm.nih.gov/41687921/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,41283828,Calorie Restriction Attenuates Transcriptional Aging Signatures in White Matter Oligodendrocytes and Immune Cells of the Monkey Brain.,2026,10.1111/acel.70298,https://pubmed.ncbi.nlm.nih.gov/41283828/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,39747663,Distinct mechanisms control the specific synaptic functions of Neuroligin 1 and Neuroligin 2.,2025,10.1038/s44319-024-00286-4,https://pubmed.ncbi.nlm.nih.gov/39747663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,40286836,NRXN3-NLGN1 complex influences the development of depression induced by maternal separation in rats.,2025,10.1016/j.brainres.2025.149659,https://pubmed.ncbi.nlm.nih.gov/40286836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,40269933,"The absence of Neuroligin-1 shapes wake/sleep architecture, rhythmic and arrhythmic activities of the electrocorticogram in female mice.",2025,10.1186/s13041-025-01186-x,https://pubmed.ncbi.nlm.nih.gov/40269933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,39661696,Neuroligin 1 Regulates Autistic-Like Repetitive Behavior through Modulating the Activity of Striatal D2 Receptor-Expressing Medium Spiny Neurons.,2025,10.1002/advs.202410728,https://pubmed.ncbi.nlm.nih.gov/39661696/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,42235694,Synaptic dysfunction-related gene expression spatially correlates with widespread cortical network atrophy in temporal lobe epilepsy.,2026,10.1016/j.nbd.2026.107468,https://pubmed.ncbi.nlm.nih.gov/42235694/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,42870830,MIF-mediated intercellular crosstalk drives antigen-presenting-like cancer-associated fibroblast differentiation in triple-negative breast cancer via TGF-β signaling.,2026,10.21037/tcr-2026-1747,https://pubmed.ncbi.nlm.nih.gov/42870830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,40032531,Phosphorylation of NLGN4X Regulates Spinogenesis and Synaptic Function.,2025,10.1523/eneuro.0278-23.2025,https://pubmed.ncbi.nlm.nih.gov/40032531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,40752151,Mono(2-ethylhexyl) phthalate impairs synaptic structure via altering long non-coding RNA MALAT1 in primary hippocampal neurons.,2025,10.1016/j.ecoenv.2025.118758,https://pubmed.ncbi.nlm.nih.gov/40752151/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,39627792,Identification of a novel immune-related gene signature by single-cell and bulk sequencing for the prediction of the immune landscape and prognosis of breast cancer.,2024,10.1186/s12935-024-03589-7,https://pubmed.ncbi.nlm.nih.gov/39627792/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,37260747,A Neuroligin-1 mutation associated with Alzheimer's disease produces memory and age-dependent impairments in hippocampal plasticity.,2023,10.1016/j.isci.2023.106868,https://pubmed.ncbi.nlm.nih.gov/37260747/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,38098940,Developmental synapse pathology triggered by maternal exposure to the herbicide glufosinate ammonium.,2023,10.3389/fnmol.2023.1298238,https://pubmed.ncbi.nlm.nih.gov/38098940/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,36056393,The neuronal protein Neuroligin 1 promotes colorectal cancer progression by modulating the APC/β-catenin pathway.,2022,10.1186/s13046-022-02465-4,https://pubmed.ncbi.nlm.nih.gov/36056393/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,37770931,"Integration of single-nuclei RNA-sequencing, spatial transcriptomics and histochemistry defines the complex microenvironment of NF1-associated plexiform neurofibromas.",2023,10.1186/s40478-023-01639-1,https://pubmed.ncbi.nlm.nih.gov/37770931/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,38407877,Molecular subtype identification and prognosis stratification by a immunogenic cell death-related gene expression signature in colorectal cancer.,2024,10.1080/14737140.2024.2320187,https://pubmed.ncbi.nlm.nih.gov/38407877/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,32332783,"Neuroligin-1 is altered in the hippocampus of Alzheimer's disease patients and mouse models, and modulates the toxicity of amyloid-beta oligomers.",2020,10.1038/s41598-020-63255-6,https://pubmed.ncbi.nlm.nih.gov/32332783/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,36208768,Exploring specific biomarkers regarding neurobehavioral toxicity of lead dioxide nanoparticles in medaka fish in different water matrices.,2023,10.1016/j.scitotenv.2022.159268,https://pubmed.ncbi.nlm.nih.gov/36208768/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,32921313,A molecular insight into the dissociable regulation of associative learning and motivation by the synaptic protein neuroligin-1.,2020,10.1186/s12915-020-00848-7,https://pubmed.ncbi.nlm.nih.gov/32921313/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,34848499,DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors.,2022,10.1523/jneurosci.1003-21.2021,https://pubmed.ncbi.nlm.nih.gov/34848499/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,31311385,Epigenetic mechanisms underlying the effects of triptolide and tripchlorolide on the expression of neuroligin-1 in the hippocampus of APP/PS1 transgenic mice.,2019,10.1080/13880209.2019.1629463,https://pubmed.ncbi.nlm.nih.gov/31311385/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,28841651,Functional significance of rare neuroligin 1 variants found in autism.,2017,10.1371/journal.pgen.1006940,https://pubmed.ncbi.nlm.nih.gov/28841651/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,19926856,The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.,2009,10.1073/pnas.0809510106,https://pubmed.ncbi.nlm.nih.gov/19926856/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLGN1,ENSG00000169760,Unsafe,18755801,"Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion.",2008,10.1210/en.2008-0274,https://pubmed.ncbi.nlm.nih.gov/18755801/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,42304038,The effect of Staphylococcus aureus targeting ROS-dependent mitochondrial damage activating NLRP10 in inducing skin and soft tissue infection.,2026,10.1038/s41598-026-56137-w,https://pubmed.ncbi.nlm.nih.gov/42304038/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,42362760,C-terminal lysine residues localise NLRP10 at lipid droplets and govern NLRP10 oligomer formation.,2026,10.1038/s44319-026-00839-9,https://pubmed.ncbi.nlm.nih.gov/42362760/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,41096888,Targeting NLRP10 in Atopic Dermatitis: An Emerging Strategy to Modulate Epidermal Cell Death and Barrier Function.,2025,10.3390/ijms26199623,https://pubmed.ncbi.nlm.nih.gov/41096888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,41506445,NLRP10 ablation alleviates neuropathic pain by inhibiting excessive NIX/LC3-dependent mitophagy in the spinal cord.,2026,10.1016/j.neuropharm.2026.110831,https://pubmed.ncbi.nlm.nih.gov/41506445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,39424623,NLRP10 maintains epidermal homeostasis by promoting keratinocyte survival and P63-dependent differentiation and barrier function.,2024,10.1038/s41419-024-07146-y,https://pubmed.ncbi.nlm.nih.gov/39424623/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,41571747,NLRP10 engages oxidized DNA through a Schiff-base mechanism and dissociates from NLRP3 upon inflammasome activation.,2026,10.1038/s42003-025-09501-x,https://pubmed.ncbi.nlm.nih.gov/41571747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,41062723,Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns.,2025,10.1038/s41423-025-01354-y,https://pubmed.ncbi.nlm.nih.gov/41062723/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,40066444,The changes of NLRs family members in the brain of AD mouse model and AD patients.,2025,10.3389/fimmu.2025.1555124,https://pubmed.ncbi.nlm.nih.gov/40066444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,40124684,Analysis of ferritinophagy-related genes associated with the prognosis and regulatory mechanisms in non-small cell lung cancer.,2025,10.3389/fmed.2025.1480169,https://pubmed.ncbi.nlm.nih.gov/40124684/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,37043073,NLRP10 promotes AGEs-induced NLRP1 and NLRP3 inflammasome activation via ROS/MAPK/NF-κB signaling in human periodontal ligament cells.,2024,10.1007/s10266-023-00813-0,https://pubmed.ncbi.nlm.nih.gov/37043073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,39351983,Molecular mechanisms of emerging inflammasome complexes and their activation and signaling in inflammation and pyroptosis.,2025,10.1111/imr.13406,https://pubmed.ncbi.nlm.nih.gov/39351983/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,38648691,Manganese induces podocyte injury through regulating MTDH/ALKBH5/NLRP10 axis: Combined analysis at epidemiology and molecular biology levels.,2024,10.1016/j.envint.2024.108672,https://pubmed.ncbi.nlm.nih.gov/38648691/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,38644450,NLRP inflammasomes in health and disease.,2024,10.1186/s43556-024-00179-x,https://pubmed.ncbi.nlm.nih.gov/38644450/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,22538615,NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.,2012,10.1038/nature11012,https://pubmed.ncbi.nlm.nih.gov/22538615/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,29501574,Cigarette smoke-induced inflammation: NLRP10-mediated mechanisms.,2018,10.1016/j.tox.2018.02.010,https://pubmed.ncbi.nlm.nih.gov/29501574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,31022691,Characterization of Innate and Adaptive Immune Responses in PYNOD-Deficient Mice.,2018,10.4049/immunohorizons.1700074,https://pubmed.ncbi.nlm.nih.gov/31022691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,36432865,"Nematicidal, Acaricidal and Plant Growth-Promoting Activity of Enterobacter Endophytic Strains and Identification of Genes Associated with These Biological Activities in the Genomes.",2022,10.3390/plants11223136,https://pubmed.ncbi.nlm.nih.gov/36432865/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,29904414,PYNOD reduces microglial inflammation and consequent neurotoxicity upon lipopolysaccharides stimulation.,2018,10.3892/etm.2018.6108,https://pubmed.ncbi.nlm.nih.gov/29904414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,34725731,NOD2 and reproduction-associated NOD-like receptors have been lost during the evolution of pangolins.,2022,10.1007/s00251-021-01230-9,https://pubmed.ncbi.nlm.nih.gov/34725731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,32084391,NLRP10 ablation protects against ischemia/reperfusion-associated brain injury by suppression of neuroinflammation.,2020,10.1016/j.yexcr.2020.111912,https://pubmed.ncbi.nlm.nih.gov/32084391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,29163529,NLRP10 Enhances CD4+ T-Cell-Mediated IFNγ Response via Regulation of Dendritic Cell-Derived IL-12 Release.,2017,10.3389/fimmu.2017.01462,https://pubmed.ncbi.nlm.nih.gov/29163529/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,28931602,An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis.,2017,10.4049/jimmunol.1500832,https://pubmed.ncbi.nlm.nih.gov/28931602/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,27221772,Epidermal NLRP10 contributes to contact hypersensitivity responses in mice.,2016,10.1002/eji.201646401,https://pubmed.ncbi.nlm.nih.gov/27221772/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,35095492,Molecular Mechanisms of Epileptic Encephalopathy Caused by KCNMA1 Loss-of-Function Mutations.,2021,10.3389/fphar.2021.775328,https://pubmed.ncbi.nlm.nih.gov/35095492/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,25713392,Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration.,2015,10.1073/pnas.1501554112,https://pubmed.ncbi.nlm.nih.gov/25713392/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,23071280,Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans.,2012,10.4049/jimmunol.1201715,https://pubmed.ncbi.nlm.nih.gov/23071280/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,18769647,Constitutive and UV-B modulated transcription of Nod-like receptors and their functional partners in human corneal epithelial cells.,2008,,https://pubmed.ncbi.nlm.nih.gov/18769647/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,22672233,NLRP10 enhances Shigella-induced pro-inflammatory responses.,2012,10.1111/j.1462-5822.2012.01822.x,https://pubmed.ncbi.nlm.nih.gov/22672233/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP10,ENSG00000182261,Unsafe,15096476,"PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1.",2004,10.1093/intimm/dxh081,https://pubmed.ncbi.nlm.nih.gov/15096476/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42604930,Temporally regulated FGFR2-retinoic acid signaling mediates dura mater-suture mesenchyme interactions to prevent craniosynostosis in mice.,2026,10.1038/s41368-026-00449-0,https://pubmed.ncbi.nlm.nih.gov/42604930/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,41783765,Case Report: Neo-homozygous nonsense mutation in NLRP5 associated with early embryonic arrest in two sisters from a Chinese family.,2026,10.3389/frph.2026.1767934,https://pubmed.ncbi.nlm.nih.gov/41783765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42613275,"Corrigendum to ""Fluoride-induced male reproductive toxicity: Dual-tissue pyroptosis in the gut-testis axis mediated by inflammatory cytokines"", J. Hazard. Mater. (2026) 142537.",2026,10.1016/j.jhazmat.2026.143290,https://pubmed.ncbi.nlm.nih.gov/42613275/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42900184,Cerebrospinal fluid and dural accumulation of α-synuclein impairs CNS clearance in Parkinson's disease.,2026,10.1084/jem.20251245,https://pubmed.ncbi.nlm.nih.gov/42900184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42539836,A Case Report of Postoperative Cystic Hydrocephalus Following Duroplasty and Scalp Reconstruction in Neonatal With Aplasia Cutis Congenita and Extensive Craniodural Defect.,2026,10.1155/cris/7741728,https://pubmed.ncbi.nlm.nih.gov/42539836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42778418,[A case of IgG4-related pia mater inflammation].,2026,10.5692/clinicalneurol.cn-002284,https://pubmed.ncbi.nlm.nih.gov/42778418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42232451,Anatomical and developmental insights into the dura mater: Implications for neurosurgery and endovascular therapy.,2026,10.25259/sni_472_2026,https://pubmed.ncbi.nlm.nih.gov/42232451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42802733,Bioinspired BG/PPDO-CNP/Pluronic F-127 hydrogel fibrous dura mater with temporally programmed degradation and adhesion prevention inspired by the hierarchical architecture of dragonfly wings.,2026,10.1093/rb/rbag154,https://pubmed.ncbi.nlm.nih.gov/42802733/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42416251,"Innovative technique to cover exposed dura mater after occipital osteomyelitis, using our triple layer using matriderm. A case report.",2026,10.3389/fsurg.2026.1788499,https://pubmed.ncbi.nlm.nih.gov/42416251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,41738556,Loss of meningeal lymphatic endothelial cells results in formation of a newly forming vascular network with scavenging function.,2026,10.1242/dev.204988,https://pubmed.ncbi.nlm.nih.gov/41738556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42327648,"Corrigendum to 'Biosynthesis, characterisation and biocompatibility of a unique and elastomeric medium chain-length polyhydroxyalkanoate for kidney glomerular tissue engineering' [Mater. Today Bio 33 (2025), 101932].",2026,10.1016/j.mtbio.2026.103209,https://pubmed.ncbi.nlm.nih.gov/42327648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42748092,Dura mater-preserving technique for fetal brain extraction after intrauterine death with prolonged retention.,2026,10.1111/1556-4029.70474,https://pubmed.ncbi.nlm.nih.gov/42748092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42788170,&lt;sup&gt;18&lt;/sup&gt; F-FDG and &lt;sup&gt;68&lt;/sup&gt; Ga-FAPI PET/CT Imaging in a Patient with High-Grade Meningioma: A Case Report.,2026,10.1055/s-0046-1825774,https://pubmed.ncbi.nlm.nih.gov/42788170/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,41845445,"The meninges as a neuroimmune interface: structure, barriers and roles in CNS disease.",2026,10.1186/s12987-026-00795-5,https://pubmed.ncbi.nlm.nih.gov/41845445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,41252458,"An Nlrp5-null mutation leads to attenuated de novo methylation in oocytes, accompanied by a significant reduction in DNMT3L.",2025,10.1093/molehr/gaaf055,https://pubmed.ncbi.nlm.nih.gov/41252458/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42773104,Compartmentalized B cell-microglia crosstalk drives ischemic white matter demyelination.,2026,10.1038/s41467-026-76817-5,https://pubmed.ncbi.nlm.nih.gov/42773104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42618784,Functional role of skull lymphoid structures in CNS immunosurveillance.,2026,10.1038/s41586-026-10951-4,https://pubmed.ncbi.nlm.nih.gov/42618784/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,41828362,Genetic Mutations and Non-Genomic Dysregulation in Human Preimplantation Embryo Arrest.,2026,10.3390/ijms27052135,https://pubmed.ncbi.nlm.nih.gov/41828362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42763760,Neomembrane Formation Suggestive of an Organized Chronic Subdural Hematoma: An Incidental Cadaveric Finding.,2026,10.7759/cureus.114874,https://pubmed.ncbi.nlm.nih.gov/42763760/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42376673,Intracranial angiomatoid fibrous histiocytoma in a 2-month-old infant: a rare case report.,2026,10.3389/fonc.2026.1679314,https://pubmed.ncbi.nlm.nih.gov/42376673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42852702,Correction: Dual-enzyme decorated semiconducting polymer nanoagents for second near-infrared photoactivatable ferroptosis-immunotherapy.,2026,10.1039/d6mh90112c,https://pubmed.ncbi.nlm.nih.gov/42852702/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42749580,"Corrigendum to ""Zebrafish sperm toxicity tests: An emerging in vitro and in vivo model for male reproductive toxicity"" [J Hazard Mater 502 (2026) 141006].",2026,10.1016/j.jhazmat.2026.143588,https://pubmed.ncbi.nlm.nih.gov/42749580/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42744727,"Corrigendum to ""Norgestrel shows androgenic properties and triggers reproductive neuroendocrine toxicity in the testes of Pacific oysters (Crassostrea gigas)""[J Hazard Mater 494 (2025) 138467].",2026,10.1016/j.jhazmat.2026.143590,https://pubmed.ncbi.nlm.nih.gov/42744727/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,41923986,Corrigendum to 'Engineered nano-bacteria hybrids for precision cancer immunotherapy' [Mater. Today Bio &lt;b&gt;35&lt;/b&gt; (2025) 102484].,2026,10.1016/j.mtbio.2026.102836,https://pubmed.ncbi.nlm.nih.gov/41923986/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,41923984,Corrigendum to 'Co-delivery paclitaxel and IR783 as nanoparticles for potentiated chemo-photothermal-immunotherapy of triple-negative breast cancer' [Mater. Today Bio &lt;b&gt;33&lt;/b&gt; (2025) 101993].,2026,10.1016/j.mtbio.2025.102067,https://pubmed.ncbi.nlm.nih.gov/41923984/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42716830,"Corrigendum to ""High-throughput heart rate monitoring in Daphnia magna for sublethal ecotoxicological assessment"" [J Hazard Mater 505(2026) 141474].",2026,10.1016/j.jhazmat.2026.143436,https://pubmed.ncbi.nlm.nih.gov/42716830/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42580917,"""Corrigendum to unraveling Jasmonic acid-mediated mitigation of 6PPD toxicity in tomato plants using multi-omics approaches"" [J Hazard Mater 514 (2026) 142926].",2026,10.1016/j.jhazmat.2026.143233,https://pubmed.ncbi.nlm.nih.gov/42580917/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42680667,"Corrigendum to ""Short-term exposure to multiple air pollutants and synergistic effects on asthma hospitalization in children: A nationwide case-crossover study in China"" [J Hazard Mater, vol. 505, 1 March 2026, 141456].",2026,10.1016/j.jhazmat.2026.143437,https://pubmed.ncbi.nlm.nih.gov/42680667/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42595595,"Corrigendum to ""Comprehensive evaluation of disinfectants on the horizontal transfer of antibiotic resistance genes mediated by SXT integrative conjugative elements"" [J. Hazard. Mater. 506 (March) (2026) 141504].",2026,10.1016/j.jhazmat.2026.143281,https://pubmed.ncbi.nlm.nih.gov/42595595/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42749581,"Corrigendum to ""Defect-rich intermetallic Pt&lt;sub&gt;3&lt;/sub&gt;Sn nanocrystals as colorimetric signal amplifiers for sensitive immunochromatographic detection of early-stage bacterial contamination"" [J Hazard Mater 500 (2025) 140597].",2026,10.1016/j.jhazmat.2026.143585,https://pubmed.ncbi.nlm.nih.gov/42749581/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42804497,"Riboflavin-sensitized UVA collagen crosslinking produced a controllable, dose-dependent increase in the nanomechanical strength of ex vivo bovine dura mater.",2026,10.1371/journal.pone.0351819,https://pubmed.ncbi.nlm.nih.gov/42804497/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,40524977,"Corrigendum to ""Gene engineered exosome reverses T cell exhaustion in cancer immunotherapy"" [Bioact. Mater. 34 (2024) 466-481].",2025,10.1016/j.bioactmat.2025.05.019,https://pubmed.ncbi.nlm.nih.gov/40524977/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,41608234,"Corrigendum to 'A dual-functional in situ hydrogel for delivering vitamin E-based lipid nanoparticles to enhance cancer immunotherapy' [Mater. Today Bio, Volume 35, December 2025, 102289].",2026,10.1016/j.mtbio.2025.102743,https://pubmed.ncbi.nlm.nih.gov/41608234/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42266367,Exploring the analgesic effect of artificial dura mater as a carrier for local hydromorphone delivery in posterior lumbar interbody fusion: a randomized controlled trial.,2026,10.3389/fphar.2026.1816434,https://pubmed.ncbi.nlm.nih.gov/42266367/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42333560,Corrigendum to: Migrasomes: A Novel Target for Cancer Treatment.,2026,10.2174/1568009626999260619155514,https://pubmed.ncbi.nlm.nih.gov/42333560/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,41643677,Meningeal blood vessel blockage enhances anti-glioblastoma immunity.,2026,10.1016/j.cell.2025.12.045,https://pubmed.ncbi.nlm.nih.gov/41643677/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,41958504,Intrahippocampal injection in mice used for experimental studies in Alzheimer's disease: a challenging procedure for neuroscience purposes.,2026,10.25122/jml-2026-0017,https://pubmed.ncbi.nlm.nih.gov/41958504/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,42524137,Multi-layer brain-mimicking phantom for replicating dura and pia membrane dimpling and rupture properties during neural interface implantation.,2026,10.3389/fneur.2026.1800280,https://pubmed.ncbi.nlm.nih.gov/42524137/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,30877238,Mutations in NLRP2 and NLRP5 cause female infertility characterised by early embryonic arrest.,2019,10.1136/jmedgenet-2018-105936,https://pubmed.ncbi.nlm.nih.gov/30877238/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,19542546,MATER protein as substrate of PKCepsilon in human cumulus cells.,2009,10.1093/molehr/gap048,https://pubmed.ncbi.nlm.nih.gov/19542546/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP5,ENSG00000171487,Unsafe,11925379,"A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development.",2002,10.1093/humrep/17.4.903,https://pubmed.ncbi.nlm.nih.gov/11925379/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,42588606,&lt;i&gt;NLRP7&lt;/i&gt; in Hydatidiform Mole and Gestational Trophoblastic Neoplasia: From Maternal-Effect Biology to a Genetic Permissiveness Framework for Integrated Cancer Surveillance and Reproductive Decision-Making.,2026,10.3390/cancers18152386,https://pubmed.ncbi.nlm.nih.gov/42588606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,41786744,TCL1A mediates DNA methylation defects in recurrent hydatidiform mole with NLRP7 pathogenic variants.,2026,10.1038/s41467-026-69744-y,https://pubmed.ncbi.nlm.nih.gov/41786744/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,42006372,Artificial intelligence-driven high-content imaging decodes for NLRP7-mutant recurrent hydatidiform moles.,2026,10.1016/j.isci.2026.115479,https://pubmed.ncbi.nlm.nih.gov/42006372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,41284890,Modulation of the PGRMC1/NLRP7/HLA-C axis by autophagy is linked to both spontaneous preterm birth and gestational choriocarcinoma.,2025,10.1073/pnas.2509798122,https://pubmed.ncbi.nlm.nih.gov/41284890/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,42868582,Analysis of the Expression of the New NLRP7 Gene c.1374-1375del Mutation.,2026,10.1615/critreveukaryotgeneexpr.2026063918,https://pubmed.ncbi.nlm.nih.gov/42868582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,41828362,Genetic Mutations and Non-Genomic Dysregulation in Human Preimplantation Embryo Arrest.,2026,10.3390/ijms27052135,https://pubmed.ncbi.nlm.nih.gov/41828362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,42530271,GSDMB as a Therapeutic and Prognostic Target in Clear Cell Renal Cell Carcinoma: Insights From Pyroptosis-Related Gene Analysis.,2026,10.31083/fbl51233,https://pubmed.ncbi.nlm.nih.gov/42530271/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,40908712,The retrospective data analysis of NLRP7 and KHDC3L mutations in Turkish patients with recurrent hydatidiform mole.,2025,10.4274/tjod.galenos.2025.40456,https://pubmed.ncbi.nlm.nih.gov/40908712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,41285996,Prognostic value assessment and in vitro validation of mitochondria-ferroptosis-related genes in multiple myeloma.,2025,10.1038/s41598-025-25476-5,https://pubmed.ncbi.nlm.nih.gov/41285996/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,41535518,Generation and characterization of human iPSC lines (FAHZJUi001-A and FAHZJUi002-A) from two familial recurrent hydatidiform mole patients carrying homozygous mutation in the NLRP7 gene.,2026,10.1007/s13577-025-01346-0,https://pubmed.ncbi.nlm.nih.gov/41535518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,40066444,The changes of NLRs family members in the brain of AD mouse model and AD patients.,2025,10.3389/fimmu.2025.1555124,https://pubmed.ncbi.nlm.nih.gov/40066444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,39697539,AH-6809 mediated regulation of lung adenocarcinoma metastasis through NLRP7 and prognostic analysis of key metastasis-related genes.,2024,10.3389/fphar.2024.1486265,https://pubmed.ncbi.nlm.nih.gov/39697539/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,42755046,Beyond NLRP3: expanding the spectrum of NLR-associated autoinflammatory diseases.,2026,10.1093/rheumatology/keag518,https://pubmed.ncbi.nlm.nih.gov/42755046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,41840546,The signature of pyroptosis-related gene diagnosis and immune microenvironment in preeclampsia.,2026,10.1186/s12884-026-08946-0,https://pubmed.ncbi.nlm.nih.gov/41840546/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,39865169,NLRP7 maintains the genomic stability during early human embryogenesis via mediating alternative splicing.,2025,10.1038/s42003-025-07571-5,https://pubmed.ncbi.nlm.nih.gov/39865169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,41062723,Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns.,2025,10.1038/s41423-025-01354-y,https://pubmed.ncbi.nlm.nih.gov/41062723/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,41619226,Bidirectional genetic and phenotypic links between smoking and striatal iron content involving dopaminergic and inflammatory pathways.,2026,10.1111/add.70311,https://pubmed.ncbi.nlm.nih.gov/41619226/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,39052836,HLA-C expression in extravillous trophoblasts is determined by an ELF3-NLRP2/NLRP7 regulatory axis.,2024,10.1073/pnas.2404229121,https://pubmed.ncbi.nlm.nih.gov/39052836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,40333895,A PANoptosis-Based Signature for Survival and Immune Predication in Glioblastoma Multiforme.,2025,10.1002/acn3.70066,https://pubmed.ncbi.nlm.nih.gov/40333895/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,41924769,A distinct plasma lipidomic signature and multi-omics network in depression of polycystic ovary syndrome.,2026,10.1016/j.jpba.2026.117486,https://pubmed.ncbi.nlm.nih.gov/41924769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,37228386,Changes in expression levels of Nod-like receptors in the spleen of ewes.,2023,10.1590/1984-3143-ar2022-0093,https://pubmed.ncbi.nlm.nih.gov/37228386/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,35203462,Role of NLRP7 in Normal and Malignant Trophoblast Cells.,2022,10.3390/biomedicines10020252,https://pubmed.ncbi.nlm.nih.gov/35203462/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,39351983,Molecular mechanisms of emerging inflammasome complexes and their activation and signaling in inflammation and pyroptosis.,2025,10.1111/imr.13406,https://pubmed.ncbi.nlm.nih.gov/39351983/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,36560538,Modulation of Nod-like Receptor Expression in the Thymus during Early Pregnancy in Ewes.,2022,10.3390/vaccines10122128,https://pubmed.ncbi.nlm.nih.gov/36560538/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,34554362,NLRP7 variants in spontaneous abortions with multilocus imprinting disturbances from women with recurrent pregnancy loss.,2021,10.1007/s10815-021-02312-z,https://pubmed.ncbi.nlm.nih.gov/34554362/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,34226539,Identification of the pyroptosis‑related prognostic gene signature and the associated regulation axis in lung adenocarcinoma.,2021,10.1038/s41420-021-00557-2,https://pubmed.ncbi.nlm.nih.gov/34226539/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,35242200,A Pyroptosis-Related Gene Signature to Predict Patients' Prognosis and Immune Landscape in Liver Hepatocellular Carcinoma.,2022,10.1155/2022/1258480,https://pubmed.ncbi.nlm.nih.gov/35242200/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,39342548,Exploring a new signature for lung adenocarcinoma: analyzing cuproptosis-related genes through Integrated single-cell and bulk RNA sequencing.,2024,10.1007/s12672-024-01389-z,https://pubmed.ncbi.nlm.nih.gov/39342548/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,38644450,NLRP inflammasomes in health and disease.,2024,10.1186/s43556-024-00179-x,https://pubmed.ncbi.nlm.nih.gov/38644450/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,31795138,NLRP7 Is Involved in the Differentiation of the Decidual Macrophages.,2019,10.3390/ijms20235994,https://pubmed.ncbi.nlm.nih.gov/31795138/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,36071753,Development and validation of a prognostic model related to pyroptosis-related genes for esophageal squamous cell carcinoma using bioinformatics analysis.,2022,10.21037/jtd-22-948,https://pubmed.ncbi.nlm.nih.gov/36071753/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,16462743,Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans.,2006,10.1038/ng1740,https://pubmed.ncbi.nlm.nih.gov/16462743/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NLRP7,ENSG00000167634,Unsafe,15817483,"PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion.",2005,10.1074/jbc.m410057200,https://pubmed.ncbi.nlm.nih.gov/15817483/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,41483244,Bioinformatics and experimental approaches identify NME8 as a promoter of the metastasis of renal cell carcinoma by activating the JAK/STAT signaling pathway.,2026,10.1007/s10238-025-02026-x,https://pubmed.ncbi.nlm.nih.gov/41483244/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,39368984,Nme8 is essential for protection against chemotherapy drug cisplatin-induced male reproductive toxicity in mice.,2024,10.1038/s41419-024-07118-2,https://pubmed.ncbi.nlm.nih.gov/39368984/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,33603952,"Testis-Specific Thioredoxins TXNDC2, TXNDC3, and TXNDC6 Are Expressed in Both Testicular and Systemic DLBCL and Correlate with Clinical Disease Presentation.",2021,10.1155/2021/8026941,https://pubmed.ncbi.nlm.nih.gov/33603952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,38948197,Identification of Biomarkers Associated with Oxidative Stress and Immune Cells in Acute Pancreatitis.,2024,10.2147/jir.s459044,https://pubmed.ncbi.nlm.nih.gov/38948197/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,36761693,Identification of microtubule-associated biomarkers in diffuse large B-cell lymphoma and prognosis prediction.,2022,10.3389/fgene.2022.1092678,https://pubmed.ncbi.nlm.nih.gov/36761693/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,38473892,Exploring the Genetic Landscape of Mild Behavioral Impairment as an Early Marker of Cognitive Decline: An Updated Review Focusing on Alzheimer's Disease.,2024,10.3390/ijms25052645,https://pubmed.ncbi.nlm.nih.gov/38473892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,38283355,Identification and validation of hub genes and molecular classifications associated with chronic myeloid leukemia.,2023,10.3389/fimmu.2023.1297886,https://pubmed.ncbi.nlm.nih.gov/38283355/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,31966386,A novel missense variant in TXNDC3 is associated with developmental dysplasia of the hip in Han Chinese population.,2017,,https://pubmed.ncbi.nlm.nih.gov/31966386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,33555136,iNPH-the mystery resolving.,2021,10.15252/emmm.202013720,https://pubmed.ncbi.nlm.nih.gov/33555136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,34252604,A transcriptome-wide association study to detect novel genes for volumetric bone mineral density.,2021,10.1016/j.bone.2021.116106,https://pubmed.ncbi.nlm.nih.gov/34252604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,35240017,Genome-wide association study for frozen-thawed sperm motility in stallions across various horse breeds.,2022,10.5713/ab.21.0504,https://pubmed.ncbi.nlm.nih.gov/35240017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,28984604,Alzheimer's Disease-Related Polymorphisms in Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus.,2017,10.3233/jad-170583,https://pubmed.ncbi.nlm.nih.gov/28984604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,25486118,"Association between NME8 locus polymorphism and cognitive decline, cerebrospinal fluid and neuroimaging biomarkers in Alzheimer's disease.",2014,10.1371/journal.pone.0114777,https://pubmed.ncbi.nlm.nih.gov/25486118/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,27144521,NME8 rs2718058 polymorphism with Alzheimer's disease risk: a replication and meta-analysis.,2016,10.18632/oncotarget.9086,https://pubmed.ncbi.nlm.nih.gov/27144521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,26414614,CD33 modulates TREM2: convergence of Alzheimer loci.,2015,10.1038/nn.4126,https://pubmed.ncbi.nlm.nih.gov/26414614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,30833143,Redox regulation of motile cilia in airway disease.,2019,10.1016/j.redox.2019.101146,https://pubmed.ncbi.nlm.nih.gov/30833143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,30378268,Association of Alzheimer's genetic loci with mild behavioral impairment.,2018,10.1002/ajmg.b.32684,https://pubmed.ncbi.nlm.nih.gov/30378268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,33213512,Genetic associations of in vivo pathology influence Alzheimer's disease susceptibility.,2020,10.1186/s13195-020-00722-2,https://pubmed.ncbi.nlm.nih.gov/33213512/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,17360648,A common variant in combination with a nonsense mutation in a member of the thioredoxin family causes primary ciliary dyskinesia.,2007,10.1073/pnas.0611405104,https://pubmed.ncbi.nlm.nih.gov/17360648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,24951455,Alzheimer's disease risk genes and mechanisms of disease pathogenesis.,2015,10.1016/j.biopsych.2014.05.006,https://pubmed.ncbi.nlm.nih.gov/24951455/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,28054028,The effect of the top 20 Alzheimer disease risk genes on gray-matter density and FDG PET brain metabolism.,2016,10.1016/j.dadm.2016.12.003,https://pubmed.ncbi.nlm.nih.gov/28054028/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,24829845,Late-Onset Alzheimer's Disease Genes and the Potentially Implicated Pathways.,2014,10.1007/s40142-014-0034-x,https://pubmed.ncbi.nlm.nih.gov/24829845/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,26993346,Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease.,2016,10.1016/j.jalz.2016.01.010,https://pubmed.ncbi.nlm.nih.gov/26993346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,16642435,Cis- and trans-acting gene regulation is associated with osteoarthritis.,2006,10.1086/503849,https://pubmed.ncbi.nlm.nih.gov/16642435/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME8,ENSG00000086288,Unsafe,11737268,"Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells.",2001,10.1046/j.1365-2443.2001.00484.x,https://pubmed.ncbi.nlm.nih.gov/11737268/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME9,ENSG00000181322,Unsafe,40091773,"Oxidative stress markers 8-OHdG, Trx-1, and Prx6 are expressed in seminoma and are connected to TXNDC2, 3, and 6 expression levels.",2025,10.14670/hh-18-898,https://pubmed.ncbi.nlm.nih.gov/40091773/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME9,ENSG00000181322,Unsafe,33603952,"Testis-Specific Thioredoxins TXNDC2, TXNDC3, and TXNDC6 Are Expressed in Both Testicular and Systemic DLBCL and Correlate with Clinical Disease Presentation.",2021,10.1155/2021/8026941,https://pubmed.ncbi.nlm.nih.gov/33603952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME9,ENSG00000181322,Unsafe,31877804,Characterization of Nme5-Like Gene/Protein from the Red Alga Chondrus Crispus.,2019,10.3390/md18010013,https://pubmed.ncbi.nlm.nih.gov/31877804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME9,ENSG00000181322,Unsafe,19852809,"Nme protein family evolutionary history, a vertebrate perspective.",2009,10.1186/1471-2148-9-256,https://pubmed.ncbi.nlm.nih.gov/19852809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NME9,ENSG00000181322,Unsafe,12569107,Characterization of human thioredoxin-like 2. A novel microtubule-binding thioredoxin expressed predominantly in the cilia of lung airway epithelium and spermatid manchette and axoneme.,2003,10.1074/jbc.m300369200,https://pubmed.ncbi.nlm.nih.gov/12569107/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,34065612,"Cancer Testis Antigen, NOL4, Is an Immunogenic Antigen Specifically Expressed in Small-Cell Lung Cancer.",2021,10.3390/curroncol28030179,https://pubmed.ncbi.nlm.nih.gov/34065612/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,42119039,Diagnostic utility of anchored multiplex polymerase chain reaction-based fusion assay on sacrificed cytology slides.,2026,10.1002/cncy.70105,https://pubmed.ncbi.nlm.nih.gov/42119039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,37372085,Towards a More Comprehensive Picture of the MicroRNA-23a/b-3p Impact on Impaired Male Fertility.,2023,10.3390/biology12060800,https://pubmed.ncbi.nlm.nih.gov/37372085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,42833294,FGFR2/3-Altered Intrahepatic Cholangiocarcinoma: A Distinct Clinicopathologic and Molecular Subtype Associated with Improved Disease-Specific Survival.,2026,10.1016/j.modpat.2026.101094,https://pubmed.ncbi.nlm.nih.gov/42833294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,36950598,Gene-based cancer-testis antigens as prognostic indicators in hepatocellular carcinoma.,2023,10.1016/j.heliyon.2023.e13269,https://pubmed.ncbi.nlm.nih.gov/36950598/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,40095160,Identification of GJC1 as a novel diagnostic marker for papillary thyroid carcinoma using weighted gene co-expression network analysis and machine learning algorithm.,2025,10.1007/s12672-025-02137-7,https://pubmed.ncbi.nlm.nih.gov/40095160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,37284456,Nanoblock-mediated selective oncolytic polypeptide therapy for triple-negative breast cancer.,2023,10.7150/thno.81834,https://pubmed.ncbi.nlm.nih.gov/37284456/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,38827371,Language: the ignored determinant of health.,2024,10.1093/pch/pxad066,https://pubmed.ncbi.nlm.nih.gov/38827371/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,37399175,Identification of Immune Subtypes and Candidate mRNA Vaccine Antigens in Small Cell Lung Cancer.,2023,10.1093/oncolo/oyad193,https://pubmed.ncbi.nlm.nih.gov/37399175/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,37410306,Translational and structural vaccinomics approach to design a multi-epitope vaccine against NOL4 autologous antigen of small cell lung cancer.,2023,10.1007/s12026-023-09404-1,https://pubmed.ncbi.nlm.nih.gov/37410306/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,36282054,NOL4 is a novel nuclear marker of small cell carcinoma and other neuroendocrine neoplasms.,2022,10.14670/hh-18-540,https://pubmed.ncbi.nlm.nih.gov/36282054/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,39199284,Identification of Tumor Budding-Associated Genes in Breast Cancer through Transcriptomic Profiling and Network Diffusion Analysis.,2024,10.3390/biom14080896,https://pubmed.ncbi.nlm.nih.gov/39199284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,33613681,&lt;i&gt;NOL4&lt;/i&gt; is Downregulated and Hyper-Methylated in Papillary Thyroid Carcinoma Suggesting Its Role as a Tumor Suppressor Gene.,2020,10.5812/ijem.108510,https://pubmed.ncbi.nlm.nih.gov/33613681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,34868271,Comprehensive Transcriptomic Profiling of Murine Osteoclast Differentiation Reveals Novel Differentially Expressed Genes and LncRNAs.,2021,10.3389/fgene.2021.781272,https://pubmed.ncbi.nlm.nih.gov/34868271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,33415070,A Protein Microarray-Based Investigation of Cerebrospinal Fluid Reveals Distinct Autoantibody Signature in Low and High-Grade Gliomas.,2020,10.3389/fonc.2020.543947,https://pubmed.ncbi.nlm.nih.gov/33415070/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,37352078,Mining of clinical and prognosis related genes in the tumor microenvironment of endometrial cancer: A field synopsis of observational study.,2023,10.1097/md.0000000000034047,https://pubmed.ncbi.nlm.nih.gov/37352078/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,28125049,Mblk-1 Transcription Factor Family: Its Roles in Various Animals and Regulation by NOL4 Splice Variants in Mammals.,2017,10.3390/ijms18020246,https://pubmed.ncbi.nlm.nih.gov/28125049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,31578039,Short- and long-term impact of hyperoxia on the blood and retinal cells' transcriptome in a mouse model of oxygen-induced retinopathy.,2020,10.1038/s41390-019-0598-y,https://pubmed.ncbi.nlm.nih.gov/31578039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,29666346,Genetic heterogeneity in Van der Woude syndrome: identification of NOL4 and IRF6 haplotype from the noncoding region as candidates in two families.,2018,10.1007/s12041-018-0903-2,https://pubmed.ncbi.nlm.nih.gov/29666346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,39060982,Detection and evaluation of parameters influencing the identification of heterozygous-enriched regions in Holstein cattle based on SNP chip or whole-genome sequence data.,2024,10.1186/s12864-024-10642-2,https://pubmed.ncbi.nlm.nih.gov/39060982/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,32074080,Identification of prognostic immune-related genes in the tumor microenvironment of endometrial cancer.,2020,10.18632/aging.102817,https://pubmed.ncbi.nlm.nih.gov/32074080/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,26295306,"Combined expressional analysis, bioinformatics and targeted proteomics identify new potential therapeutic targets in glioblastoma stem cells.",2015,10.18632/oncotarget.4613,https://pubmed.ncbi.nlm.nih.gov/26295306/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4,ENSG00000101746,Unsafe,9813152,NOLP: identification of a novel human nucleolar protein and determination of sequence requirements for its nucleolar localization.,1998,10.1006/bbrc.1998.9606,https://pubmed.ncbi.nlm.nih.gov/9813152/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4L,ENSG00000197183,Unsafe,42055623,Integrated Proteomics Reveal ALDH1A1 as an Oncogenic Driver and Regulatory Hub in Hepatocellular Carcinoma.,2026,10.21873/cgp.20582,https://pubmed.ncbi.nlm.nih.gov/42055623/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4L,ENSG00000197183,Unsafe,33837793,"Circ_0132817 facilitates cell proliferation, migration, invasion and glycolysis by regulating the miR-432-5p/NOL4L axis in neuroblastoma.",2021,10.1007/s00221-021-06091-y,https://pubmed.ncbi.nlm.nih.gov/33837793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4L,ENSG00000197183,Unsafe,33940382,"NOL4L, a novel nuclear protein, promotes cell proliferation and metastasis by enhancing the PI3K/AKT pathway in ovarian cancer.",2021,10.1016/j.bbrc.2021.04.055,https://pubmed.ncbi.nlm.nih.gov/33940382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4L,ENSG00000197183,Unsafe,37528361,Drivers of plateau adaptability in cashmere goats revealed by genomic and transcriptomic analyses.,2023,10.1186/s12864-023-09333-1,https://pubmed.ncbi.nlm.nih.gov/37528361/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4L,ENSG00000197183,Unsafe,32522628,LncRNA double homeobox A pseudogene 8 (DUXAP8) facilitates the progression of neuroblastoma and activates Wnt/β-catenin pathway via microRNA-29/nucleolar protein 4 like (NOL4L) axis.,2020,10.1016/j.brainres.2020.146947,https://pubmed.ncbi.nlm.nih.gov/32522628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4L,ENSG00000197183,Unsafe,33635749,Silencing of circular RNA circPDE5A suppresses neuroblastoma progression by targeting the miR-362-5p/NOL4L axis.,2023,10.1080/00207454.2021.1896505,https://pubmed.ncbi.nlm.nih.gov/33635749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4L,ENSG00000197183,Unsafe,31645055,Silencing CASC11 curbs neonatal neuroblastoma progression through modulating microRNA-676-3p/nucleolar protein 4 like (NOL4L) axis.,2020,10.1038/s41390-019-0625-z,https://pubmed.ncbi.nlm.nih.gov/31645055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4L,ENSG00000197183,Unsafe,26934290,Nucleolar protein 4-like has a complex expression pattern in zebrafish embryos.,2016,10.1387/ijdb.150307rs,https://pubmed.ncbi.nlm.nih.gov/26934290/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4L,ENSG00000197183,Unsafe,18697940,Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray.,2008,10.1073/pnas.0711039105,https://pubmed.ncbi.nlm.nih.gov/18697940/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4L,ENSG00000197183,Unsafe,21765475,Dominant-negative mechanism of leukemogenic PAX5 fusions.,2012,10.1038/onc.2011.291,https://pubmed.ncbi.nlm.nih.gov/21765475/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4L,ENSG00000197183,Unsafe,19586940,Heterogeneous breakpoints in patients with acute lymphoblastic leukemia and the dic(9;20)(p11-13;q11) show recurrent involvement of genes at 20q11.21.,2009,10.3324/haematol.2008.002808,https://pubmed.ncbi.nlm.nih.gov/19586940/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOL4L,ENSG00000197183,Unsafe,18957548,Variable breakpoints target PAX5 in patients with dicentric chromosomes: a model for the basis of unbalanced translocations in cancer.,2008,10.1073/pnas.0803494105,https://pubmed.ncbi.nlm.nih.gov/18957548/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,42828282,Cancer cell-intrinsic rewiring of the colorectal cancer secretome.,2026,10.1016/j.isci.2026.117525,https://pubmed.ncbi.nlm.nih.gov/42828282/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,42097145,A tumor-intrinsic WNT-inhibitory NOTUM program drives immune resistance in microsatellite stable colorectal cancer.,2026,10.1016/j.xcrm.2026.102776,https://pubmed.ncbi.nlm.nih.gov/42097145/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,42528355,Serum Wnt Pathway Regulators in Adolescents with Suicidal Behavior Disorder and Nonsuicidal Self-injury Disorder: A Case-control Study.,2026,10.9758/cpn.26.1419,https://pubmed.ncbi.nlm.nih.gov/42528355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,41453989,Notum1a Inhibition promotes neurogenesis in the adult zebrafish brain.,2025,10.1038/s41598-025-33883-x,https://pubmed.ncbi.nlm.nih.gov/41453989/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,41596299,NOTUM Enhances Cartilage Repair via Wnt/β-Catenin Modulation in a Rabbit Osteochondral Defect Model.,2026,10.3390/ijms27020647,https://pubmed.ncbi.nlm.nih.gov/41596299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,42220510,Characterization of the tumor microenvironment in locally advanced gastric cancer and identification of spatially predictive biomarkers associated with beneficial neoadjuvant immunochemotherapy.,2026,10.3389/fimmu.2026.1823308,https://pubmed.ncbi.nlm.nih.gov/42220510/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,42139301,Functions of Uninflatable in the Drosophila melanogaster wing and notum.,2026,10.1371/journal.pone.0344871,https://pubmed.ncbi.nlm.nih.gov/42139301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,41236758,Notum disrupts Wnt/β-catenin-mediated BMP9 osteogenesis in MSCs: implications for bone regeneration.,2026,10.1080/03008207.2025.2582827,https://pubmed.ncbi.nlm.nih.gov/41236758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,42204944,Regulators of Wnt Signaling Dkk-1 and Notum Are Elevated in Pediatric ADHD.,2026,10.1002/dneu.70042,https://pubmed.ncbi.nlm.nih.gov/42204944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,40893669,High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis.,2025,10.1016/j.apsb.2025.06.004,https://pubmed.ncbi.nlm.nih.gov/40893669/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,42627852,Hippo signaling regulates cuticle pigmentation and dopamine metabolism in Drosophila.,2026,10.1371/journal.pgen.1012260,https://pubmed.ncbi.nlm.nih.gov/42627852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,40685976,Notum as a Crucial Regulator of Matrix Integrity in Dentinogenesis.,2025,10.1002/jcp.70070,https://pubmed.ncbi.nlm.nih.gov/40685976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,41099308,egal-1 and microtubules promote regeneration polarity in planarians.,2025,10.1242/dev.204668,https://pubmed.ncbi.nlm.nih.gov/41099308/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,40739628,NR1I3 modulates Wnt signaling to promote anterior-posterior axis patterning.,2025,10.1186/s12915-025-02346-0,https://pubmed.ncbi.nlm.nih.gov/40739628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,41852738,Hbs and Rst adhesion molecules provide a regional code that regulates cell elimination during epithelial remodeling.,2026,10.1016/j.isci.2026.114971,https://pubmed.ncbi.nlm.nih.gov/41852738/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,41099309,Planarian microtubules form a network within muscle and regulate injury-induced genes essential for regeneration patterning.,2025,10.1242/dev.204669,https://pubmed.ncbi.nlm.nih.gov/41099309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,42907449,Short-term memory of past caspase activity biases cell elimination in vivo.,2026,10.1038/s41467-026-77685-9,https://pubmed.ncbi.nlm.nih.gov/42907449/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,42294399,"The &lt;i&gt;melanized&lt;/i&gt; ( &lt;i&gt;mel&lt;/i&gt; ) locus of &lt;i&gt;Drosophila melanogaster&lt;/i&gt; is a mutation in CG17065, an N-acetylglucosamine-6-phosphate deacetylase.",2026,10.17912/micropub.biology.002178,https://pubmed.ncbi.nlm.nih.gov/42294399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,41875878,Drift of positional identity drives reproductive aging in a long-lived regenerative animal.,2026,10.1016/j.cub.2026.02.050,https://pubmed.ncbi.nlm.nih.gov/41875878/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,40271154,Wnt5a and Notum influence the temporal dynamics of cartilaginous mesenchymal condensations in developing trachea.,2025,10.3389/fcell.2025.1523833,https://pubmed.ncbi.nlm.nih.gov/40271154/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,40370532,Comprehensive investigation of multiple targets in the development of newer drugs for the Alzheimer's disease.,2025,10.1016/j.apsb.2024.11.016,https://pubmed.ncbi.nlm.nih.gov/40370532/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,41767748,"Discovery of anthraquinones as potent Notum inhibitors for treating osteoporosis by integrating biochemical, phytochemical, computational, and experimental assays.",2026,10.1016/j.jpha.2025.101256,https://pubmed.ncbi.nlm.nih.gov/41767748/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,41734764,VIPR1 acts as an enteric neural checkpoint that suppresses intestinal stem cell-driven epithelial regeneration and exacerbates colitis.,2026,10.1016/j.stem.2026.01.009,https://pubmed.ncbi.nlm.nih.gov/41734764/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,41604971,Small-molecule-based activation of Wnt/β-catenin signaling: An underexplored yet promising strategy for neuroprotection.,2026,10.1016/j.bioorg.2026.109540,https://pubmed.ncbi.nlm.nih.gov/41604971/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,39404424,Upregulation of Fatty Acid Synthase Increases Activity of β-Catenin and Expression of NOTUM to Enhance Stem-like Properties of Colorectal Cancer Cells.,2024,10.3390/cells13191663,https://pubmed.ncbi.nlm.nih.gov/39404424/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,39325428,NOTUM-mediated WNT silencing drives extravillous trophoblast cell lineage development.,2024,10.1073/pnas.2403003121,https://pubmed.ncbi.nlm.nih.gov/39325428/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,41878503,Wnt16: a new potential therapeutic target for osteoporotic non-vertebral fracture treatment.,2026,10.3389/fragi.2026.1768566,https://pubmed.ncbi.nlm.nih.gov/41878503/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,37749430,Notum enhances gastric cancer stem-like cell properties through upregulation of Sox2 by PI3K/AKT signaling pathway.,2024,10.1007/s13402-023-00875-w,https://pubmed.ncbi.nlm.nih.gov/37749430/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,41667411,Systematic generation of &lt;i&gt;Drosophila&lt;/i&gt; Wnt transgenes enables the characterization of canonical Wnt signaling.,2026,10.1080/19336934.2026.2624185,https://pubmed.ncbi.nlm.nih.gov/41667411/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,41480606,Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches.,2025,10.4239/wjd.v16.i12.111963,https://pubmed.ncbi.nlm.nih.gov/41480606/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,41657547,The lncRNA GAS5-encoded micropeptide facilitates influenza virus replication through modulation of the Wnt/β-catenin signaling pathway.,2026,10.1016/j.crmicr.2026.100559,https://pubmed.ncbi.nlm.nih.gov/41657547/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,40593722,Lipoic acid functions in Paneth cells to prevent human intestinal stem cell aging.,2025,10.1038/s41467-025-61070-z,https://pubmed.ncbi.nlm.nih.gov/40593722/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,36934521,Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.,2023,10.1016/j.ejmech.2023.115132,https://pubmed.ncbi.nlm.nih.gov/36934521/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,35536179,"Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.",2022,10.1021/acs.jmedchem.2c00162,https://pubmed.ncbi.nlm.nih.gov/35536179/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOTUM,ENSG00000185269,Unsafe,18429952,"Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF.",2008,10.1111/j.1349-7006.2008.00814.x,https://pubmed.ncbi.nlm.nih.gov/18429952/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOXRED1,ENSG00000165555,Unsafe,41327383,Integrative bioinformatics and machine learning approach unveils potential biomarkers linking coronary atherosclerosis and glutamine metabolism-associated gene.,2025,10.1186/s13019-025-03685-3,https://pubmed.ncbi.nlm.nih.gov/41327383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOXRED1,ENSG00000165555,Unsafe,36948142,Integrated analysis of metabolomic and transcriptomic profiling reveals the effect of Buyang Huanwu decoction on Parkinson's disease in mice.,2023,10.1016/j.phymed.2023.154755,https://pubmed.ncbi.nlm.nih.gov/36948142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NOXRED1,ENSG00000165555,Unsafe,31435991,Genetic variants in glutamine metabolic pathway genes predict cutaneous melanoma-specific survival.,2019,10.1002/mc.23100,https://pubmed.ncbi.nlm.nih.gov/31435991/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,42493024,NPFF2 regulate thiamethoxam resistance by over-expressing CYP6CX4 in Bemisia tabaci.,2026,10.1016/j.pestbp.2026.107213,https://pubmed.ncbi.nlm.nih.gov/42493024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,42476067,Direct current electric field induces non-linear NPFFR2 accumulation and alters its predicted conformational stability in murine thioglycolate-elicited peritoneal macrophages.,2026,10.1016/j.bbrc.2026.154213,https://pubmed.ncbi.nlm.nih.gov/42476067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,39755369,Roles for Prlhr/GPR10 and Npffr2/GPR74 in feeding responses to PrRP.,2025,10.1016/j.molmet.2024.102093,https://pubmed.ncbi.nlm.nih.gov/39755369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,42214470,Displaced minds: ecologies of depression.,2026,10.1016/j.bj.2026.101000,https://pubmed.ncbi.nlm.nih.gov/42214470/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,40946914,Neuropeptide FF receptor 2 overexpression aggravates lipid accumulation and metabolic dysfunction in mice with diet-induced metabolic stress.,2026,10.1016/j.bj.2025.100913,https://pubmed.ncbi.nlm.nih.gov/40946914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,41351901,Direct current electric field suppresses NPFFR2 expression in macrophages and alters its predicted conformational dynamics.,2026,10.1016/j.bbrc.2025.153094,https://pubmed.ncbi.nlm.nih.gov/41351901/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,41123466,NPFFR2 Deletion Improves Hypothalamic Insulin Sensitivity and Metabolic Outcomes in Mice With Diet-induced Obesity.,2025,10.1210/endocr/bqaf157,https://pubmed.ncbi.nlm.nih.gov/41123466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,42494597,Translating physical stress into biological signals: precision electro-oncology based on conformational changes of electro-sensitive receptors and parameterized immune remodeling.,2026,10.3389/fonc.2026.1854341,https://pubmed.ncbi.nlm.nih.gov/42494597/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,41301948,Recessive Effect of &lt;i&gt;GC-NPFFR2&lt;/i&gt; rs137147462 on Somatic Cell Score (Mastitis Susceptibility) in Japanese Holsteins.,2025,10.3390/ani15223239,https://pubmed.ncbi.nlm.nih.gov/41301948/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,42770033,Genetic Sequencing in Saudi Patients with Systemic Lupus Erythematosus.,2026,10.2147/oarrr.s621173,https://pubmed.ncbi.nlm.nih.gov/42770033/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,39769048,An Overview on Renal and Central Regulation of Blood Pressure by Neuropeptide FF and Its Receptors.,2024,10.3390/ijms252413284,https://pubmed.ncbi.nlm.nih.gov/39769048/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,39440369,Deficiency of GPR10 and NPFFR2 receptors leads to sex-specific prediabetic syndrome and late-onset obesity in mice.,2024,10.1042/bsr20241103,https://pubmed.ncbi.nlm.nih.gov/39440369/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,40128413,Structural insights into the selective recognition of RF-amide peptides by neuropeptide FF receptor 2.,2025,10.1038/s44319-025-00428-2,https://pubmed.ncbi.nlm.nih.gov/40128413/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,39926678,Serum Neuropeptide FFR2 is increased in pregnant women with pre-eclampsia and associated with pregnancy outcomes.,2025,10.12669/pjms.41.2.10591,https://pubmed.ncbi.nlm.nih.gov/39926678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,40362394,Prolactin-Releasing Peptide System as a Potential Mechanism of Stress Coping: Studies in Male Rats.,2025,10.3390/ijms26094155,https://pubmed.ncbi.nlm.nih.gov/40362394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,39397407,"[The Relationship between Serum Neuropeptide FFR2, Serum Smoothelin and Pregnancy Outcomes in Pregnant Women with Gestational Hypertension].",2024,10.5543/tkda.2024.10241,https://pubmed.ncbi.nlm.nih.gov/39397407/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,37191311,NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose.,2023,10.1042/cs20220880,https://pubmed.ncbi.nlm.nih.gov/37191311/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,40666184,Endurance training promotes the browning of WAT by enhancing the NPFF pathway in the hypothalamus in rats with type 2 diabetes.,2025,10.22038/ijbms.2025.74876.17966,https://pubmed.ncbi.nlm.nih.gov/40666184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,38301284,Hypothalamic NPFFR2 attenuates central insulin signaling and its knockout diminishes metabolic dysfunction in mouse models of diabetes mellitus.,2024,10.1016/j.clnu.2024.01.013,https://pubmed.ncbi.nlm.nih.gov/38301284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,36497331,NPFFR2 Contributes to the Malignancy of Hepatocellular Carcinoma Development by Activating RhoA/YAP Signaling.,2022,10.3390/cancers14235850,https://pubmed.ncbi.nlm.nih.gov/36497331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,39641914,Hederagenin is a Highly Selective Antagonist of the Neuropeptide FF Receptor 1 that Reveals Mechanisms for Subtype Selectivity.,2025,10.1002/anie.202417786,https://pubmed.ncbi.nlm.nih.gov/39641914/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,39243426,Intrathecal administration of MCRT produced potent antinociception in chronic inflammatory pain models via μ-δ heterodimer with limited side effects.,2024,10.1016/j.biopha.2024.117389,https://pubmed.ncbi.nlm.nih.gov/39243426/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,33202667,Ablation of NPFFR2 in Mice Reduces Response to Single Prolonged Stress Model.,2020,10.3390/cells9112479,https://pubmed.ncbi.nlm.nih.gov/33202667/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,36579330,"Effects of immune inflammation in head and neck squamous cell carcinoma: Tumor microenvironment, drug resistance, and clinical outcomes.",2022,10.3389/fgene.2022.1085700,https://pubmed.ncbi.nlm.nih.gov/36579330/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,36319817,Meta-analysis of epigenome-wide association studies of major depressive disorder.,2022,10.1038/s41598-022-22744-6,https://pubmed.ncbi.nlm.nih.gov/36319817/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,31790916,"Bioanalytical method development and validation of MES207, a neuropeptide FF receptor antagonist, and its application in preclinical pharmacokinetics.",2019,10.1016/j.jchromb.2019.121875,https://pubmed.ncbi.nlm.nih.gov/31790916/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,34177089,Next Generation Sequencing of 502 Lifestyle and Nutrition related Genetic Polymorphisms reveals Independent Loci for Low Serum 25-hydroxyvitamin D Levels among Adult Respondents of the 2013 Philippine National Nutrition Survey.,2021,10.15605/jafes.036.01.08,https://pubmed.ncbi.nlm.nih.gov/34177089/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,28613414,The Arg-Phe-amide peptide 26RFa/glutamine RF-amide peptide and its receptor: IUPHAR Review 24.,2017,10.1111/bph.13907,https://pubmed.ncbi.nlm.nih.gov/28613414/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPFFR2,ENSG00000056291,Unsafe,10079187,Sequence and tissue distribution of a novel G-protein-coupled receptor expressed prominently in human placenta.,1999,10.1006/bbrc.1999.0332,https://pubmed.ncbi.nlm.nih.gov/10079187/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,42336469,Spatiotemporal dynamics of renal distal convoluted tubule dilatation and cyst formation in nephronophthisis type 1 mice.,2026,10.1080/0886022x.2026.2684840,https://pubmed.ncbi.nlm.nih.gov/42336469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,39995111,"Kibra knockdown inhibits the aberrant Hippo pathway, suppresses renal cyst formation and ameliorates renal fibrosis in nphp1&lt;sup&gt;KO&lt;/sup&gt; mice.",2025,10.1002/ctm2.70245,https://pubmed.ncbi.nlm.nih.gov/39995111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,40776899,Urinary renal epithelial cells can be used for NPHP1 phenotyping and a personalized therapeutic strategy.,2025,10.1242/jcs.264141,https://pubmed.ncbi.nlm.nih.gov/40776899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,41354125,ZONAB regulates renal cyst formation in nphp1 knockout mice.,2025,10.1016/j.trsl.2025.12.001,https://pubmed.ncbi.nlm.nih.gov/41354125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,40968381,iPSC-based drug discovery identified the Hippo signaling pathway as a therapeutic target in the fibrosis of NPHP1-deficient nephronophthisis.,2025,10.1186/s13287-025-04567-0,https://pubmed.ncbi.nlm.nih.gov/40968381/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,39098869,Immunofluorescence analyses of respiratory epithelial cells aid the diagnosis of nephronophthisis.,2024,10.1007/s00467-024-06443-0,https://pubmed.ncbi.nlm.nih.gov/39098869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,42792940,"Insight into Essential and Complex Autism Spectrum Disorders: Clinical Characteristics, Chromosomal Microarray Analysis, and Risk Factors.",2026,10.3390/genes17091045,https://pubmed.ncbi.nlm.nih.gov/42792940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,41383614,Synthetic DNA co-immunization with vaccine-aligned common consensus nucleoprotein and hemagglutinin protects mice against lethal influenza infection with a single immunization.,2025,10.3389/fimmu.2025.1632121,https://pubmed.ncbi.nlm.nih.gov/41383614/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,40620856,Case Report: A renal wasting disease caused by a pure deletion of nephrocystin-1.,2025,10.3389/fped.2025.1541411,https://pubmed.ncbi.nlm.nih.gov/40620856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,42400345,Nephronophthisis: Current clinical spectrum and molecular pathogenesis.,2026,10.1111/febs.70646,https://pubmed.ncbi.nlm.nih.gov/42400345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,42780563,Genomic spectrum of congenital heart disease combined with kidney and urinary tract anomalies uncovered by exome sequencing and array-CGH.,2026,10.3389/fcell.2026.1862793,https://pubmed.ncbi.nlm.nih.gov/42780563/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,42483414,Whole exome sequencing identified a novel compound heterozygous mutation of &lt;i&gt;nephrocystin 4&lt;/i&gt; in a child with nephronophthisis-a rare case report.,2026,10.3389/fped.2026.1864993,https://pubmed.ncbi.nlm.nih.gov/42483414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,38989059,Patient-derived and gene-edited pluripotent stem cells lacking NPHP1 recapitulate juvenile nephronophthisis in abnormalities of primary cilia and renal cyst formation.,2024,10.3389/fcell.2024.1370723,https://pubmed.ncbi.nlm.nih.gov/38989059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,42734259,Phenotypic and Genotypic Landscape of Sitosterolemia in China: Including a Rare Case With Nephronophthisis.,2026,10.1002/mgg3.70293,https://pubmed.ncbi.nlm.nih.gov/42734259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,40806500,Targeting GLP-1 Signaling Ameliorates Cystogenesis in a Zebrafish Model of Nephronophthisis.,2025,10.3390/ijms26157366,https://pubmed.ncbi.nlm.nih.gov/40806500/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,41878779,Rapidly Progressive Kidney Failure With Transient Non-Cystic Kidney Enlargement: A Case Report Highlighting Delayed Medullary Cyst Formation.,2026,10.1111/nep.70198,https://pubmed.ncbi.nlm.nih.gov/41878779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,40704549,Sub-ciliary localization of CEP290 and effects of its loss in mouse photoreceptors during development.,2025,10.1242/jcs.263869,https://pubmed.ncbi.nlm.nih.gov/40704549/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,37583898,Identification of renal cyst cells of type I Nephronophthisis by single-nucleus RNA sequencing.,2023,10.3389/fcell.2023.1192935,https://pubmed.ncbi.nlm.nih.gov/37583898/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,40814642,Prostaglandin Analogs and Eupatilin as Treatments for Nephronophthisis.,2025,10.1016/j.ekir.2025.04.060,https://pubmed.ncbi.nlm.nih.gov/40814642/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,37663822,NPHP1-Related ciliopathies: A new case and major review of the ophthalmic manifestations of 147 reported cases.,2023,10.1002/ccr3.7818,https://pubmed.ncbi.nlm.nih.gov/37663822/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,42221480,Potassium-solubilizing bacteria from tropical forest soils enhance potassium and phosphorus uptake in maize.,2026,10.3389/fmicb.2026.1788341,https://pubmed.ncbi.nlm.nih.gov/42221480/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,36948406,A case report of two Chinese monozygotic twins with NPHP1 gene-associated nephronophthisis undergoing kidney transplantation from a related living-donor.,2023,10.1016/j.trim.2023.101828,https://pubmed.ncbi.nlm.nih.gov/36948406/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,40247009,Non-invasive screening for liver fibrosis by acoustic radiation force impulse in patients with ciliopathies.,2025,10.1038/s41598-025-96246-6,https://pubmed.ncbi.nlm.nih.gov/40247009/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,38433745,Diverse retinal-kidney phenotypes associated with &lt;i&gt;NPHP1&lt;/i&gt; homozygous whole-gene deletions in patients with kidney failure.,2024,10.1007/s44162-024-00031-4,https://pubmed.ncbi.nlm.nih.gov/38433745/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,35482924,Agonists of prostaglandin E2 receptors as potential first in class treatment for nephronophthisis and related ciliopathies.,2022,10.1073/pnas.2115960119,https://pubmed.ncbi.nlm.nih.gov/35482924/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,38581567,Peritoneal dialysis-associated infection caused by Mycobacterium abscessus in a pediatric patient on continuous peritoneal dialysis without switching to hemodialysis.,2024,10.1007/s13730-024-00875-1,https://pubmed.ncbi.nlm.nih.gov/38581567/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,31922211,Auxiliary genetic analysis in a Chinese adolescent NPH family by single nucleotide polymorphism screening.,2020,10.3892/mmr.2020.10917,https://pubmed.ncbi.nlm.nih.gov/31922211/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,29146700,Phenotypic Spectrum of Children with Nephronophthisis and Related Ciliopathies.,2017,10.2215/cjn.01280217,https://pubmed.ncbi.nlm.nih.gov/29146700/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,32363171,"Interpretation of Autosomal Recessive Kidney Diseases With ""Presumed Homozygous"" Pathogenic Variants Should Consider Technical Pitfalls.",2020,10.3389/fped.2020.00165,https://pubmed.ncbi.nlm.nih.gov/32363171/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,29925518,"Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney.",2018,10.15252/embj.201798615,https://pubmed.ncbi.nlm.nih.gov/29925518/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,32132867,Difference of genomic copy numbers alterations between hairy cell leukemia-variant and classical hairy cell leukemia: a pilot retrospective study in Chinese.,2020,10.7150/ijms.39307,https://pubmed.ncbi.nlm.nih.gov/32132867/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,30055837,Joubert Syndrome: Ophthalmological Findings in Correlation with Genotype and Hepatorenal Disease in 99 Patients Prospectively Evaluated at a Single Center.,2018,10.1016/j.ophtha.2018.05.026,https://pubmed.ncbi.nlm.nih.gov/30055837/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,21658830,Genetic diagnosis in consanguineous families with kidney disease by homozygosity mapping coupled with whole-exome sequencing.,2011,10.1053/j.ajkd.2011.01.025,https://pubmed.ncbi.nlm.nih.gov/21658830/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,26540106,Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling.,2015,10.1371/journal.pgen.1005627,https://pubmed.ncbi.nlm.nih.gov/26540106/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,25517981,Increased expression of MERTK is associated with a unique form of canine retinopathy.,2014,10.1371/journal.pone.0114552,https://pubmed.ncbi.nlm.nih.gov/25517981/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,22654112,The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling.,2012,10.1074/jbc.m112.385658,https://pubmed.ncbi.nlm.nih.gov/22654112/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,18477472,Nephrocystin-1 interacts directly with Ack1 and is expressed in human collecting duct.,2008,10.1016/j.bbrc.2008.05.016,https://pubmed.ncbi.nlm.nih.gov/18477472/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NPHP1,ENSG00000144061,Unsafe,16308564,Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia.,2005,10.1038/sj.emboj.7600885,https://pubmed.ncbi.nlm.nih.gov/16308564/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,41611698,"NR6A1 is essential for neural crest cell specification, formation and survival.",2026,10.1038/s41467-026-68647-2,https://pubmed.ncbi.nlm.nih.gov/41611698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,41219936,The nuclear receptor NR6A1 plays an oncogenic role through reprogramming glycolysis in tumors.,2025,10.1186/s40659-025-00646-x,https://pubmed.ncbi.nlm.nih.gov/41219936/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,40610405,Variants in NR6A1 cause a novel oculo vertebral renal syndrome.,2025,10.1038/s41467-025-60574-y,https://pubmed.ncbi.nlm.nih.gov/40610405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,40275155,CircRNA profiling reveals circSMC1B that promotes bovine male germline stem cells proliferation and apoptosis via sponging let-7i.,2025,10.1186/s12864-025-11556-3,https://pubmed.ncbi.nlm.nih.gov/40275155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,40709394,OAC1 improves mitofusin 2 expression to alleviate neuronal injury following experimental ischemic stroke.,2025,10.4196/kjpp.24.428,https://pubmed.ncbi.nlm.nih.gov/40709394/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,41733738,"Variants in NR6A1 as a cause for congenital renal, vertebral and uterine anomalies.",2026,10.1007/s00439-025-02806-1,https://pubmed.ncbi.nlm.nih.gov/41733738/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,39259438,Mitofusin 2 Mediates the Protective Effect of NR6A1 Silencing Against Neuronal Injury in Experimental Stroke Models.,2025,10.1007/s12035-024-04466-0,https://pubmed.ncbi.nlm.nih.gov/39259438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,38440075,The expanding roles of Nr6a1 in development and evolution.,2024,10.3389/fcell.2024.1357968,https://pubmed.ncbi.nlm.nih.gov/38440075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,40584630,Identification of an Ara-C resistance-related gene risk score and the role of S100A4 in AML via NR6A1-dependent activation and p53 regulation.,2025,10.3389/fphar.2025.1574759,https://pubmed.ncbi.nlm.nih.gov/40584630/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,40774958,Exome analysis links kidney malformations to developmental disorders and reveals causal genes.,2025,10.1038/s41467-025-62319-3,https://pubmed.ncbi.nlm.nih.gov/40774958/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,41261143,Identification of novel vertebral development factors through UK Biobank candidate gene search and body imaging analysis.,2025,10.1038/s42003-025-09021-8,https://pubmed.ncbi.nlm.nih.gov/41261143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,38323281,miR-99b/let-7e/miR-125a cluster suppresses pancreatic cancer through regulation of NR6A1.,2024,10.62347/xgrj9404,https://pubmed.ncbi.nlm.nih.gov/38323281/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,39624078,Breast cancer cell resistance to hormonal and targeted therapeutics is correlated with the inactivation of the NR6A1 axis.,2024,10.20517/cdr.2024.69,https://pubmed.ncbi.nlm.nih.gov/39624078/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,36136852,TGF-β-Upregulated Lnc-Nr6a1 Acts as a Reservoir of miR-181 and Mediates Assembly of a Glycolytic Complex.,2022,10.3390/ncrna8050062,https://pubmed.ncbi.nlm.nih.gov/36136852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,40252971,Laminin-γ2-NR6A1 Fusion Protein Promotes Metastatic Potential in Non-Small-Cell Lung Carcinoma Cells without Epidermal Growth Factor Receptor Mutation.,2025,10.1016/j.ajpath.2025.03.006,https://pubmed.ncbi.nlm.nih.gov/40252971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,36522318,Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development.,2022,10.1038/s41467-022-35303-4,https://pubmed.ncbi.nlm.nih.gov/36522318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,40988222,Inhibition of lactylation by LRP1 expression increases the risk of intervertebral disc degeneration: A multi-omics summary-based Mendelian randomization analysis.,2025,10.1097/md.0000000000044795,https://pubmed.ncbi.nlm.nih.gov/40988222/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,41550951,SPACA6-hosted miR-99b~125a~let-7e cluster shapes melanoma resistance by modulating mTOR-mediated immunosuppression.,2025,10.3389/fimmu.2025.1719461,https://pubmed.ncbi.nlm.nih.gov/41550951/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,36304495,Establishment of a Prognostic Model for Hepatocellular Carcinoma Based on Bioinformatics and the Role of NR6A1 in the Progression of HCC.,2022,10.14218/jcth.2022.00191,https://pubmed.ncbi.nlm.nih.gov/36304495/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,40218384,Application of Omics in Donkey Meat Research: A Review.,2025,10.3390/ani15070991,https://pubmed.ncbi.nlm.nih.gov/40218384/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,37903971,"Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma.",2023,10.1038/s41598-023-46057-4,https://pubmed.ncbi.nlm.nih.gov/37903971/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,42422030,A comprehensive and standardized dataset on school feeding activities worldwide: The Global Survey of School Meal Programs.,2026,10.1016/j.dib.2026.113018,https://pubmed.ncbi.nlm.nih.gov/42422030/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,39053546,Microcystin-LR prenatal exposure induces coronary heart disease through macrophage polarization imbalance mediated by trophoblast-derived extracellular vesicles.,2024,10.1016/j.scitotenv.2024.174979,https://pubmed.ncbi.nlm.nih.gov/39053546/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,39210812,Understanding molecular mechanisms of vertebral number of variations on Mongolian sheep using candidate genes analysis.,2025,10.5713/ab.24.0212,https://pubmed.ncbi.nlm.nih.gov/39210812/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,38754473,A 10-Gene Signature to Predict the Prognosis of Early-Stage Triple-Negative Breast Cancer.,2024,10.4143/crt.2024.100,https://pubmed.ncbi.nlm.nih.gov/38754473/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,38779358,Transcriptomic Profiling in Low-Risk Thyroid Cancer Induced by Microwave Ablation.,2024,10.1155/2024/6674506,https://pubmed.ncbi.nlm.nih.gov/38779358/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,38505001,Copy number variants selected during pig domestication inferred from whole genome resequencing.,2024,10.3389/fvets.2024.1364267,https://pubmed.ncbi.nlm.nih.gov/38505001/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,41375522,Overview of Donkey Welfare and Husbandry Practices in Asia.,2025,10.3390/ani15233464,https://pubmed.ncbi.nlm.nih.gov/41375522/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,28454554,Impaired lysosomal activity mediated autophagic flux disruption by graphite carbon nanofibers induce apoptosis in human lung epithelial cells through oxidative stress and energetic impairment.,2017,10.1186/s12989-017-0194-4,https://pubmed.ncbi.nlm.nih.gov/28454554/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,38840048,Whole-genome sequencing reveals genomic diversity and selection signatures in Xia'nan cattle.,2024,10.1186/s12864-024-10463-3,https://pubmed.ncbi.nlm.nih.gov/38840048/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,36071851,Nalidixic acid potentiates the antitumor activity in sorafenib-resistant hepatocellular carcinoma via the tumor immune microenvironment analysis.,2022,10.3389/fphar.2022.952482,https://pubmed.ncbi.nlm.nih.gov/36071851/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,33791879,"Impact of platelet-rich plasma versus selenium in ameliorating induced toxicity in rat testis: histological, immunohistochemical, and molecular study.",2021,10.1007/s00441-021-03439-2,https://pubmed.ncbi.nlm.nih.gov/33791879/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,9537518,"Cloning, expression analysis and chromosomal localization of the human nuclear receptor gene GCNF.",1998,10.1016/s0014-5793(98)00142-2,https://pubmed.ncbi.nlm.nih.gov/9537518/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,9493564,Cloning of the human NCNF gene.,1998,10.3109/10799899809039161,https://pubmed.ncbi.nlm.nih.gov/9493564/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,9177477,cDNA cloning of two closely related forms of human germ cell nuclear factor (GCNF).,1997,10.1016/s0167-4781(97)00043-2,https://pubmed.ncbi.nlm.nih.gov/9177477/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,9134503,Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation.,1997,10.1677/jme.0.0180167,https://pubmed.ncbi.nlm.nih.gov/9134503/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NR6A1,ENSG00000148200,Unsafe,8982251,Characterization of the human germ cell nuclear factor gene.,1996,10.1016/s0167-4781(96)00157-1,https://pubmed.ncbi.nlm.nih.gov/8982251/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42782805,"Neuregulin-1 as a Context-Dependent Regulator of Neuroinflammation and Neural Repair: Mechanisms, Disease Relevance, and Therapeutic Challenges.",2026,10.3390/cells15181705,https://pubmed.ncbi.nlm.nih.gov/42782805/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42884023,Cell Tropism-Related Gene Signatures in MDD Identified by Transcriptomic Analysis and Rat Model Validation.,2026,10.3390/ijms27198780,https://pubmed.ncbi.nlm.nih.gov/42884023/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,41992305,"Structure, mechanism and clinical relevance of NRG1 fusions in cancer.",2026,10.1186/s12929-026-01242-1,https://pubmed.ncbi.nlm.nih.gov/41992305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42589468,Recognition of ErbB Family Dimers by the EGF-like Domain of NRG1alpha and Beta: Implications for Ligand-Based CAR Therapy.,2026,10.3390/ijms27156813,https://pubmed.ncbi.nlm.nih.gov/42589468/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42023299,Esketamine ameliorates depression-like behavior in mice via modulation of the NRG1-ErbB4 pathway.,2026,10.3389/fpsyt.2026.1722336,https://pubmed.ncbi.nlm.nih.gov/42023299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42415515,Single-nuclei RNA sequencing reveals heterogeneity within developing GnRH3 neurons in zebrafish.,2026,10.1111/jne.70230,https://pubmed.ncbi.nlm.nih.gov/42415515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42518135,Signaling pathways regulating cardiac regeneration.,2026,10.1186/s13619-026-00297-7,https://pubmed.ncbi.nlm.nih.gov/42518135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,41476674,Neuregulin-1 Secreted by Cancer-Associated Fibroblasts Promotes Growth of Triple-Negative Breast Cancer.,2025,10.2147/bctt.s549363,https://pubmed.ncbi.nlm.nih.gov/41476674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,41798642,NRG1 Suppresses NLRP3 Inflammasome Activation and Endothelial-Mesenchymal Transition in Cerebral Ischemia-Reperfusion Injury: Association with the AKT/NF-κB Pathway.,2026,10.2147/jir.s584926,https://pubmed.ncbi.nlm.nih.gov/41798642/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42212327,Impaired Neuregulin 1 Processing is Associated with Synaptic and Behavioral Abnormalities in a Prenatal Valproic Acid Model of Autism.,2026,10.7150/ijbs.133137,https://pubmed.ncbi.nlm.nih.gov/42212327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42706502,Clinicopathologic Features of NRG1 Fusion-Positive Non-Small Cell Lung Cancer.,2026,10.1002/gcc.70170,https://pubmed.ncbi.nlm.nih.gov/42706502/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,41717642,Nrg1 regulates cortical wiring and motor recovery upon traumatic injury.,2026,10.3389/fncel.2026.1734342,https://pubmed.ncbi.nlm.nih.gov/41717642/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42760283,RhoA in postnatal spinal motoneuron is essential for peripheral myelination.,2026,10.1038/s42003-026-10779-8,https://pubmed.ncbi.nlm.nih.gov/42760283/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42432033,Single-cell RNA sequencing of hematopoietic and non-hematopoietic cells defines a distinct signature in atopic and NRG1 mouse lung.,2026,10.1038/s41598-026-61413-w,https://pubmed.ncbi.nlm.nih.gov/42432033/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42786848,Roles of the Neuregulin 1/ErbB4 Signaling Pathway in the Pathogenesis of Autism Spectrum Disorder.,2026,10.2174/011570159x479511260904044527,https://pubmed.ncbi.nlm.nih.gov/42786848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42196592,Neuregulin-1β Mitigates Doxorubicin-Induced Cardiotoxicity via &lt;i&gt;Serping1&lt;/i&gt; in Cardiac Fibroblasts.,2026,10.3390/ijms27104616,https://pubmed.ncbi.nlm.nih.gov/42196592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42305451,Prognostic value and potential upstream regulator of Schwann cells in esophageal squamous cell carcinoma.,2026,10.21037/tcr-2026-1-0276,https://pubmed.ncbi.nlm.nih.gov/42305451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,41516377,&lt;i&gt;Candida albicans&lt;/i&gt; Extracellular Vesicles Upregulate Nrg1 Transcription Repressor to Inhibit Self-Hyphal Development and Candidemia.,2026,10.3390/ijms27010495,https://pubmed.ncbi.nlm.nih.gov/41516377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,41555462,Characterizing the molecular and clinical implications of NRG1 fusions in NSCLC through integrated RNA and DNA sequencing analysis.,2026,10.1186/s40001-025-03831-6,https://pubmed.ncbi.nlm.nih.gov/41555462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42163376,Single-cell analysis reveals that NRG1/3-ERBB4 signaling affects metabolic reprogramming and immune escape in Wilms tumor.,2026,10.1186/s13062-026-00780-w,https://pubmed.ncbi.nlm.nih.gov/42163376/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42395618,"Bispecific Antibodies in Solid Tumors: Mechanistic Insights, Clinical Advances, and Future Directions.",2026,10.36401/jipo-25-36,https://pubmed.ncbi.nlm.nih.gov/42395618/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42385125,Efficacy and Tolerability of Zenocutuzumab in Advanced &lt;i&gt;NRG1&lt;/i&gt; Fusion-Positive Cholangiocarcinoma: Results From the eNRGy Phase II Trial.,2026,10.1200/jco-25-03128,https://pubmed.ncbi.nlm.nih.gov/42385125/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42278436,HER2 Therapies in Non-Small Cell Lung Cancer (NSCLC).,2026,10.3390/ijms27114910,https://pubmed.ncbi.nlm.nih.gov/42278436/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42723803,"NRG1 fusions in non-small cell lung cancer: biology, diagnostics, and emerging HER2/HER3 therapies-a narrative review.",2026,10.21037/tlcr-2026-0227,https://pubmed.ncbi.nlm.nih.gov/42723803/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42512264,The Evolving Role of Bispecific Antibodies in Oncogene-Driven NSCLC.,2026,10.3390/cancers18142197,https://pubmed.ncbi.nlm.nih.gov/42512264/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,41826994,Neoadjuvant afatinib in a patient with locally advanced lung adenocarcinoma harboring an NPTN-NRG1 fusion: a case report.,2026,10.1186/s12957-026-04233-6,https://pubmed.ncbi.nlm.nih.gov/41826994/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42763821,Genetic and Molecular Determinants of Cancer Therapy-Related Cardiovascular Toxicity.,2026,10.1007/s12012-026-10191-y,https://pubmed.ncbi.nlm.nih.gov/42763821/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42303794,Antagonizing NRG1-ERBB4 signaling pathway with spironolactone for the treatment of schizophrenia: results of a randomized controlled drug repositioning clinical trial.,2026,10.1038/s43856-026-01714-3,https://pubmed.ncbi.nlm.nih.gov/42303794/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,41808714,Analysis of clinical and genomic features in a Chinese cohort with &lt;i&gt;NRG1&lt;/i&gt; variations: a retrospective study.,2026,10.21037/tlcr-2025-aw-1293,https://pubmed.ncbi.nlm.nih.gov/41808714/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,41390931,"NRG1 fusion-positive solid tumors: clinical detection, genomic landscape, and real-world data in pancreatic cancer.",2026,10.1093/jnci/djaf361,https://pubmed.ncbi.nlm.nih.gov/41390931/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,41190067,Membraneless organelles-based integrative analysis constructs an immune-related prognostic signature and identifies NRG1 as a novel methylation biomarker in colorectal cancer.,2025,10.3389/fimmu.2025.1678096,https://pubmed.ncbi.nlm.nih.gov/41190067/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42533808,"COLEC12high tumor-associated macrophages: A novel paracrine axis driving lenvatinib resistance in hepatocellular carcinoma: Editorial on ""COLEC12high tumor-associated macrophages orchestrate lenvatinib resistance and cancer stemness in hepatocellular carcinoma via paracrine NRG1-HER2/HER3 signaling"".",2026,10.3350/cmh.2026.0219,https://pubmed.ncbi.nlm.nih.gov/42533808/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,42737745,Real-World Outcomes of Fusion-Directed Targeted Therapy in Advanced Non-Small Cell Lung Cancer Harboring Actionable Gene Fusions.,2026,10.3390/ijms27177849,https://pubmed.ncbi.nlm.nih.gov/42737745/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,40895848,Novel Therapies in Advanced Pancreatic Cancer: A Peak Beyond the Realms of Gene Targeting.,2025,10.7759/cureus.89054,https://pubmed.ncbi.nlm.nih.gov/40895848/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,40730881,"Comprehensive identification of NRG1 fusions in 25,203 patients with solid tumors.",2025,10.1038/s41698-025-01044-y,https://pubmed.ncbi.nlm.nih.gov/40730881/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRG1,ENSG00000157168,Unsafe,17565985,"Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia.",2007,10.1074/jbc.m702953200,https://pubmed.ncbi.nlm.nih.gov/17565985/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,42278214,Downregulating &lt;i&gt;Nrl&lt;/i&gt; Expression and Rod Photoreceptor Protection.,2026,10.3390/ijms27114683,https://pubmed.ncbi.nlm.nih.gov/42278214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,42246540,Stress Responsive bZIP Transcription Factors ATF4 and BACH1 Cooperate With MAF-Family bZIP Protein NRL to Fine-Tune Rod Photoreceptor Gene Expression.,2026,10.1167/iovs.67.6.9,https://pubmed.ncbi.nlm.nih.gov/42246540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,40627117,"Safety, Tolerability, and Pharmacokinetics of NRL-1049, a Rho-Associated Kinase Inhibitor, in Healthy Volunteers: A Phase 1, First-in-Human, Single-Ascending Dose, Randomized, Placebo-Controlled Trial.",2025,10.1007/s40263-025-01198-0,https://pubmed.ncbi.nlm.nih.gov/40627117/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,42918401,MAF Transcription Factors: Emerging Key Players in Cardiovascular Health and Disease.,2026,10.1016/j.biocel.2026.107055,https://pubmed.ncbi.nlm.nih.gov/42918401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,40767624,Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features.,2025,10.7554/elife.101918,https://pubmed.ncbi.nlm.nih.gov/40767624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,39815991,Protective Effect of Nerolidol on Paclitaxel-Induced Reproductive Toxicity in Rats: Oxidative Stress and Inflammation.,2025,10.1111/bcpt.14126,https://pubmed.ncbi.nlm.nih.gov/39815991/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,42226070,Blue light receptor phot2 collaborates with NRL-30 to negatively regulate immunity by reducing mitochondrial protein PRXIIF stability in potato.,2026,10.1186/s43897-025-00224-5,https://pubmed.ncbi.nlm.nih.gov/42226070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,42153745,"Prolonging ejaculatory latency with benzocaine paste-containing natural rubber latex condoms: findings from a randomized, three-way, cross-over study.",2026,10.1093/jsxmed/qdag134,https://pubmed.ncbi.nlm.nih.gov/42153745/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,42450633,"Sperm, Neutrophil and Vascular Alterations in Advanced Paternal Age Model and the Nutraceutical Effect of Açaí to Mitigate Health Vulnerability in the Male Offspring.",2026,10.3390/biology15131086,https://pubmed.ncbi.nlm.nih.gov/42450633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,38833563,The novel ROCK2 selective inhibitor NRL-1049 preserves the blood-brain barrier after acute injury.,2024,10.1177/0271678x241238845,https://pubmed.ncbi.nlm.nih.gov/38833563/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,41145579,Synergistic effects of hybrid fibres and natural rubber latex on the thermal stability and mechanical properties of high-volume fly ash concrete.,2025,10.1038/s41598-025-21392-w,https://pubmed.ncbi.nlm.nih.gov/41145579/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,42157965,"Gene therapy rescues cone function in &lt;i&gt;opn1mw&lt;/i&gt; &lt;sup&gt;-/-&lt;/sup&gt; &lt;i&gt;/opn1sw&lt;/i&gt; &lt;sup&gt;-/-&lt;/sup&gt; &lt;i&gt;/Nrl&lt;/i&gt; &lt;sup&gt;-/-&lt;/sup&gt; mice, an all-cone model of blue cone monochromacy.",2026,10.1016/j.omta.2025.201657,https://pubmed.ncbi.nlm.nih.gov/42157965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,41719245,Reversible phosphorylation of NPH3/RPT2-like proteins regulates phototropin receptor signaling.,2026,10.1093/plcell/koag043,https://pubmed.ncbi.nlm.nih.gov/41719245/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,40715177,In vivo efficacy of NRL knockdown with cell-penetrating siRNA in retinal degeneration.,2025,10.1038/s41598-025-07299-6,https://pubmed.ncbi.nlm.nih.gov/40715177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,41196344,Dynamic changes of dopamine neuron activity and plasticity at different stages of negative reinforcement learning.,2025,10.1073/pnas.2509072122,https://pubmed.ncbi.nlm.nih.gov/41196344/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,39763388,Isoform-selective and non-selective rho-kinase inhibitors do not affect collagenase-induced intracerebral hemorrhage outcomes in mice: Influence of sex and circadian cycle.,2025,10.1177/0271678x241312010,https://pubmed.ncbi.nlm.nih.gov/39763388/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,42458052,Multiscale in vivo imaging of tumor evolution using a germline conditional triple-reporter mouse.,2026,10.1038/s41587-026-03184-3,https://pubmed.ncbi.nlm.nih.gov/42458052/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,40465763,Associations between serum lipid levels and the macular retinal volumes in patients with diabetes.,2025,10.1371/journal.pone.0325500,https://pubmed.ncbi.nlm.nih.gov/40465763/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,40397675,Mechanisms of photoreceptor protection upon targeting the &lt;i&gt;Nrl-Nr2e3&lt;/i&gt; pathway.,2025,10.1073/pnas.2500446122,https://pubmed.ncbi.nlm.nih.gov/40397675/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,38179414,Role of Rho-Associated Kinase in the Pathophysiology of Cerebral Cavernous Malformations.,2024,10.1212/nxg.0000000000200121,https://pubmed.ncbi.nlm.nih.gov/38179414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,42377032,Complete genome sequence of BLRI-developed inactivated avian influenza A/H9N2 vaccine strain in Bangladesh.,2026,10.1128/mra.00304-26,https://pubmed.ncbi.nlm.nih.gov/42377032/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,41687988,Wood-inspired micro-fibrillated cellulose/natural rubber latex sponges with hierarchical tracheid structure for high-performance piezoresistive sensors.,2026,10.1016/j.ijbiomac.2026.150892,https://pubmed.ncbi.nlm.nih.gov/41687988/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,41754628,Synergistic Effects of Nitrosamine-Safe Accelerators for Enhanced Natural Rubber Latex Balloon in Sulfur Conventional Vulcanizing System.,2026,10.3390/polym18040438,https://pubmed.ncbi.nlm.nih.gov/41754628/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,42055569,Glove Reuse Limits in Hair Dyeing: Permeation of p-Phenylenediamine and Aminophenols Through Natural Rubber Latex and Neoprene After Repeated Washing.,2026,10.1111/cod.70174,https://pubmed.ncbi.nlm.nih.gov/42055569/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,40780327,"Honey-loaded natural rubber dressing for treatment of atopic dermatitis: A physicochemical, antioxidant, in vitro and in vivo characterization.",2025,10.1016/j.ijbiomac.2025.146642,https://pubmed.ncbi.nlm.nih.gov/40780327/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,42801215,"Microbiology laboratory consolidation at the National Reference Laboratory, United Arab Emirates: implementation, early outcomes, and lessons learned from a hub-and-spoke network redesign.",2026,10.1016/j.ijregi.2026.100971,https://pubmed.ncbi.nlm.nih.gov/42801215/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,41642547,"Outbreak of Salmonella Typhimurium ST19 linked to passerine birds and cats in Norway, March to July 2024.",2026,10.1007/s10096-026-05421-8,https://pubmed.ncbi.nlm.nih.gov/41642547/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,40158573,Novel highly flexible collagen-loaded latex dressing to treat diabetic foot ulcer: A pilot clinical trial.,2025,10.1016/j.ijbiomac.2025.142615,https://pubmed.ncbi.nlm.nih.gov/40158573/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,39598597,"Improving the Theranostic Potential of Magnetic Nanoparticles by Coating with Natural Rubber Latex for Ultrasound, Photoacoustic Imaging, and Magnetic Hyperthermia: An In Vitro Study.",2024,10.3390/pharmaceutics16111474,https://pubmed.ncbi.nlm.nih.gov/39598597/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,39515716,"β-Tricalcium phosphate incorporated natural rubber latex membranes for calvarial bone defects: Physicochemical, in vitro and in vivo assessment.",2024,10.1016/j.ijbiomac.2024.137328,https://pubmed.ncbi.nlm.nih.gov/39515716/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,42075687,Sensitivity and Specificity Assessment of Various African Swine Fever ELISA Kits for Accurate Detection of Seropositive Wild Boar.,2026,10.3390/pathogens15040360,https://pubmed.ncbi.nlm.nih.gov/42075687/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,37600792,"A novel necroptosis-related long noncoding RNA model for predicting clinical features, immune characteristics, and therapeutic response in clear cell renal cell carcinoma.",2023,10.3389/fimmu.2023.1230267,https://pubmed.ncbi.nlm.nih.gov/37600792/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,40414480,Comparative performance of ultrathin and standard latex condoms: A randomized multicentre trial.,2025,10.1016/j.contraception.2025.110970,https://pubmed.ncbi.nlm.nih.gov/40414480/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NRL,ENSG00000129535,Unsafe,11477108,Multiple phosphorylated isoforms of NRL are expressed in rod photoreceptors.,2001,10.1074/jbc.m105855200,https://pubmed.ncbi.nlm.nih.gov/11477108/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,42101179,Overexpression of NSUN3 suppresses ferroptosis in osteoarthritis chondrocytes by reducing m5C modification and expression of PCBP1 mRNA.,2026,10.1080/03008207.2026.2668589,https://pubmed.ncbi.nlm.nih.gov/42101179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,42670888,Hypoxia-Induced Lactylation of NSUN3 Promotes m5C Methylation of SETD2 to Regulate Peripheral Nerve Injury Repair.,2026,10.1111/jns.70166,https://pubmed.ncbi.nlm.nih.gov/42670888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,42100395,NSUN3 promotes oral squamous cell carcinoma progression through autophagy activation and FOXO pathway modulation.,2026,10.3389/fonc.2026.1807220,https://pubmed.ncbi.nlm.nih.gov/42100395/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,42921883,NSUN3-Associated m5C Modification of tRF5-GlyTCC Suppresses Colorectal Cancer Progression via RPL23-Linked Nucleolar Stress and p53-Associated Autophagy and Enhances 5-FU Sensitivity. ,2026,10.1002/advs.78345,https://pubmed.ncbi.nlm.nih.gov/42921883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,41583468,The role of 5-methylcytosine regulator-related genes in diagnostic and immune regulatory functions in atherosclerosis.,2025,10.3389/fimmu.2025.1636323,https://pubmed.ncbi.nlm.nih.gov/41583468/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,40279954,Inhibition of NSUN3 suppresses immune escape in non-small cell lung cancer through stabilizing PD-L1 in a 5-methyladenosine dependent way.,2025,10.1016/j.clinsp.2025.100662,https://pubmed.ncbi.nlm.nih.gov/40279954/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,41224163,NSUN3-mediated m5C modification of FABP5 regulates lipid droplets through autophagy to alleviate osteoarthritis progression.,2026,10.1016/j.cellsig.2025.112238,https://pubmed.ncbi.nlm.nih.gov/41224163/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,40465263,Biallelic NSUN3 Variants Cause Diverse Phenotypic Spectrum Disease: From Isolated Optic Atrophy to Severe Early-Onset Mitochondrial Disorder.,2025,10.1167/iovs.66.6.17,https://pubmed.ncbi.nlm.nih.gov/40465263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,41462962,The Role of NSUN Family Genes in m5C Methylation and Diseases.,2025,10.3390/biomedicines13122951,https://pubmed.ncbi.nlm.nih.gov/41462962/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,40240513,Evaluated NSUN3 in reticulocytes from HbH-CS disease that reflects cellular stress in erythroblasts.,2025,10.1007/s00277-025-06359-1,https://pubmed.ncbi.nlm.nih.gov/40240513/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,40549115,NSUN3-Mediated ROS Accumulation Promotes Hepatocellular Carcinoma Proliferation and Activates PI3K/AKT Pathway.,2026,10.1007/s10528-025-11158-4,https://pubmed.ncbi.nlm.nih.gov/40549115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,39924309,NSUN3 Aggravates Sepsis-Associated Acute Kidney Injury by Stabilising TIFA mRNA Through m5C.,2025,10.1111/1440-1681.70026,https://pubmed.ncbi.nlm.nih.gov/39924309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,40482605,NSUN3-mediated m&lt;sup&gt;5&lt;/sup&gt;C modification of TAK1 promotes sepsis-induced pulmonary injury through regulating inflammation.,2025,10.1016/j.molimm.2025.05.023,https://pubmed.ncbi.nlm.nih.gov/40482605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,38790159,"Mutations in NSUN3, a Mitochondrial Methyl Transferase Gene, Cause Inherited Optic Neuropathy.",2024,10.3390/genes15050530,https://pubmed.ncbi.nlm.nih.gov/38790159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,41310324,Multi-omics and experimental validation identify methylation-related genes and METTL16 as key regulators in diabetic foot ulcer pathogenesis.,2025,10.1038/s41598-025-26306-4,https://pubmed.ncbi.nlm.nih.gov/41310324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,41459880,m5C-Related Regulators Define Tumor Microenvironment and Predict Prognosis in Hepatocellular Carcinoma.,2025,10.31557/apjcp.2025.26.12.4639,https://pubmed.ncbi.nlm.nih.gov/41459880/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,39088870,Decoding the role of tRNA modifications in cancer progression.,2024,10.1016/j.gde.2024.102238,https://pubmed.ncbi.nlm.nih.gov/39088870/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,40148982,m5C methylation of mitochondrial RNA and non-coding RNA by NSUN3 is associated with variant gene expression and asexual blood-stage development in Plasmodium falciparum.,2025,10.1186/s13071-025-06746-7,https://pubmed.ncbi.nlm.nih.gov/40148982/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,40405297,Identification of m5C RNA modification-related gene signature for predicting prognosis and immune microenvironment-related characteristics of heart failure.,2025,10.1186/s41065-025-00454-z,https://pubmed.ncbi.nlm.nih.gov/40405297/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,36949224,NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice.,2023,10.1038/s42003-023-04680-x,https://pubmed.ncbi.nlm.nih.gov/36949224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,37114236,A Prognostic Model Based on NSUN3 Was Established to Evaluate the Prognosis and Response to Immunotherapy in Liver Hepatocellular Carcinoma.,2023,10.1155/2023/6645476,https://pubmed.ncbi.nlm.nih.gov/37114236/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,34195072,m5C RNA Methylation Regulators Predict Prognosis and Regulate the Immune Microenvironment in Lung Squamous Cell Carcinoma.,2021,10.3389/fonc.2021.657466,https://pubmed.ncbi.nlm.nih.gov/34195072/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,37047493,Prognostic Value and Genome Signature of m6A/m5C Regulated Genes in Early-Stage Lung Adenocarcinoma.,2023,10.3390/ijms24076520,https://pubmed.ncbi.nlm.nih.gov/37047493/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,36035311,Identification and Validation of Prognostic Markers for Lung Squamous Cell Carcinoma Associated with Chronic Obstructive Pulmonary Disease.,2022,10.1155/2022/4254195,https://pubmed.ncbi.nlm.nih.gov/36035311/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,36698387,Genetic variants in m5C modification core genes are associated with the risk of Chinese pediatric acute lymphoblastic leukemia: A five-center case-control study.,2022,10.3389/fonc.2022.1082525,https://pubmed.ncbi.nlm.nih.gov/36698387/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,34631874,Comprehensive Analysis of m5C RNA Methylation Regulator Genes in Clear Cell Renal Cell Carcinoma.,2021,10.1155/2021/3803724,https://pubmed.ncbi.nlm.nih.gov/34631874/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN3,ENSG00000178694,Unsafe,30971929,Transcriptome-Wide Effects of Sphingosine Kinases Knockdown in Metastatic Prostate and Breast Cancer Cells: Implications for Therapeutic Targeting.,2019,10.3389/fphar.2019.00303,https://pubmed.ncbi.nlm.nih.gov/30971929/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,41516134,NSUN7 Regulates Sperm Flagella Formation at All Stages of Spermiogenesis.,2025,10.3390/ijms27010257,https://pubmed.ncbi.nlm.nih.gov/41516134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,41381527,NSUN7 is a catalytically inactive RNA m&lt;sup&gt;5&lt;/sup&gt;C methyltransferase essential for sperm flagellum assembly.,2025,10.1038/s41467-025-67233-2,https://pubmed.ncbi.nlm.nih.gov/41381527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,42380284,Coordinated DNA 5-mC and RNA m&lt;sup&gt;5&lt;/sup&gt;C methylation epigenetically regulates MZF1 splice variants to drive EGFR-TKI resistance.,2026,10.1038/s12276-026-01758-4,https://pubmed.ncbi.nlm.nih.gov/42380284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,41871257,The m5C orchestrator NSUN7 drives SPARC/HMGB1 axis-mediated inflammation to exacerbate kidney injury.,2026,10.1073/pnas.2511296123,https://pubmed.ncbi.nlm.nih.gov/41871257/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,41850512,Sevoflurane activates ATF4/NSUN7/PRKCD axis to induce neurotoxicity and cognitive impairment by promoting neuron mitochondrial fission.,2026,10.1016/j.cbi.2026.112043,https://pubmed.ncbi.nlm.nih.gov/41850512/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,41062800,NSUN7-mediated m5C methylation of NLRP3 promotes pyroptosis in ovarian granulosa cells in polycystic ovary syndrome.,2025,10.1038/s41598-025-19209-x,https://pubmed.ncbi.nlm.nih.gov/41062800/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,41275291,NSUN7-mediated m&lt;sup&gt;5&lt;/sup&gt;C modification of circNTRK2 regulates stemness properties of glioblastoma cells by activating STK31.,2025,10.1186/s12967-025-07484-1,https://pubmed.ncbi.nlm.nih.gov/41275291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,41318161,&lt;i&gt;NSUN7&lt;/i&gt; Suppression Reduces Metastatic Potential and Restores Sensitivity to 4-OH Tamoxifen in Resistant MCF-7 Cells.,2025,10.21873/anticanres.17871,https://pubmed.ncbi.nlm.nih.gov/41318161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,40032361,"Positioning of sperm tail longitudinal columns depends on NSUN7, an RNA-binding protein destabilizing elongated spermatid transcripts.",2025,10.1261/rna.080320.124,https://pubmed.ncbi.nlm.nih.gov/40032361/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,40545153,Testis-specific RNA methyltransferase NSUN7 contains a re-arranged catalytic site.,2025,10.1016/j.biochi.2025.06.011,https://pubmed.ncbi.nlm.nih.gov/40545153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,40100478,Pan-cancer analysis of the prognosis and immune infiltration of NSUN7 and its potential function in renal clear cell carcinoma.,2025,10.1007/s12672-025-02061-w,https://pubmed.ncbi.nlm.nih.gov/40100478/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,41615732,NSUN7 Promotes Pyroptosis of Lung Epithelial Cells in Sepsis-induced Acute Lung Injury by Stabilizing TRAF6.,2026,10.1097/shk.0000000000002729,https://pubmed.ncbi.nlm.nih.gov/41615732/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,41462962,The Role of NSUN Family Genes in m5C Methylation and Diseases.,2025,10.3390/biomedicines13122951,https://pubmed.ncbi.nlm.nih.gov/41462962/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,39954044,NSUN7 promotes cervical cancer progression through activation of ErbB signaling pathway.,2025,10.1007/s10142-025-01546-9,https://pubmed.ncbi.nlm.nih.gov/39954044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,37173708,Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer.,2023,10.1186/s12943-023-01785-z,https://pubmed.ncbi.nlm.nih.gov/37173708/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,39648428,Exploring the Biological Effects of Polystyrene Nanoplastics on Spermatogenesis: Insights From Transcriptomic Analysis in Mouse Spermatocytes.,2025,10.1177/10915818241305086,https://pubmed.ncbi.nlm.nih.gov/39648428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,41207179,Genetic susceptibility and validation of angiographic patterns in Takayasu arteritis.,2025,10.1016/j.jaut.2025.103496,https://pubmed.ncbi.nlm.nih.gov/41207179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,36646969,Differential expression of m5C RNA methyltransferase genes NSUN6 and NSUN7 in Alzheimer's disease and traumatic brain injury.,2023,10.1007/s12035-022-03195-6,https://pubmed.ncbi.nlm.nih.gov/36646969/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,37701433,Identification and validation of key biomarkers based on RNA methylation genes in sepsis.,2023,10.3389/fimmu.2023.1231898,https://pubmed.ncbi.nlm.nih.gov/37701433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,37905873,Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders.,2024,10.4103/1673-5374.385858,https://pubmed.ncbi.nlm.nih.gov/37905873/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,37934565,Identification of M5c regulator-medicated methylation modification patterns for prognosis and immune microenvironment in glioma.,2023,10.18632/aging.205179,https://pubmed.ncbi.nlm.nih.gov/37934565/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,38600309,Comprehensive analysis of immunogenic cell death-related gene and construction of prediction model based on WGCNA and multiple machine learning in severe COVID-19.,2024,10.1038/s41598-024-59117-0,https://pubmed.ncbi.nlm.nih.gov/38600309/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,40405297,Identification of m5C RNA modification-related gene signature for predicting prognosis and immune microenvironment-related characteristics of heart failure.,2025,10.1186/s41065-025-00454-z,https://pubmed.ncbi.nlm.nih.gov/40405297/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,37047493,Prognostic Value and Genome Signature of m6A/m5C Regulated Genes in Early-Stage Lung Adenocarcinoma.,2023,10.3390/ijms24076520,https://pubmed.ncbi.nlm.nih.gov/37047493/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,35990004,Whole Exome Sequencing in a Population With Severe Congenital Anomalies of Kidney and Urinary Tract.,2022,10.3389/fped.2022.898773,https://pubmed.ncbi.nlm.nih.gov/35990004/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,35402591,5-methylcytosine RNA methylation regulators affect prognosis and tumor microenvironment in lung adenocarcinoma.,2022,10.21037/atm-22-500,https://pubmed.ncbi.nlm.nih.gov/35402591/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,36855207,Identification and verification of feature biomarkers associated with immune cells in neonatal sepsis.,2023,10.1186/s40001-023-01061-2,https://pubmed.ncbi.nlm.nih.gov/36855207/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,36105348,Transcriptional expression of m6A and m5C RNA methyltransferase genes in the brain and fat body of honey bee adult workers.,2022,10.3389/fcell.2022.921503,https://pubmed.ncbi.nlm.nih.gov/36105348/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,34359637,Identification of an RNA-Binding-Protein-Based Prognostic Model for Ewing Sarcoma.,2021,10.3390/cancers13153736,https://pubmed.ncbi.nlm.nih.gov/34359637/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,32636717,The plasma peptides of sepsis.,2020,10.1186/s12014-020-09288-5,https://pubmed.ncbi.nlm.nih.gov/32636717/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NSUN7,ENSG00000179299,Unsafe,21118569,High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5.,2010,10.1186/1471-2156-11-106,https://pubmed.ncbi.nlm.nih.gov/21118569/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5DC4,ENSG00000144130,Unsafe,40491783,Integration of Bulk and Single-Cell Transcriptomics Reveals BCL2L14 as a Novel IGKC+ T Cell-Associated Therapeutic Target in Breast Cancer.,2025,10.2147/jir.s523147,https://pubmed.ncbi.nlm.nih.gov/40491783/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5DC4,ENSG00000144130,Unsafe,37576396,The NT5DC family: expression profile and prognostic value in pancreatic adenocarcinoma.,2023,10.7150/jca.85811,https://pubmed.ncbi.nlm.nih.gov/37576396/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5DC4,ENSG00000144130,Unsafe,38373930,Metabolic subtypes and immune landscapes in esophageal squamous cell carcinoma: prognostic implications and potential for personalized therapies.,2024,10.1186/s12885-024-11890-x,https://pubmed.ncbi.nlm.nih.gov/38373930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NT5DC4,ENSG00000144130,Unsafe,33462198,Investigating cytosolic 5'-nucleotidase II family genes as candidates for neuropsychiatric disorders in Drosophila (114/150 chr).,2021,10.1038/s41398-020-01149-x,https://pubmed.ncbi.nlm.nih.gov/33462198/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,41943078,NUF2 interacts with BUB3 and drives lung adenocarcinoma progression through activation of the NF-κB pathway.,2026,10.1186/s12957-026-04319-1,https://pubmed.ncbi.nlm.nih.gov/41943078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,41626143,NDC80 kinetochore complex component is a potential molecular target of adenoid cystic carcinoma.,2026,10.3892/ol.2026.15467,https://pubmed.ncbi.nlm.nih.gov/41626143/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,42896969,[Mechanism of NUF2 in Promoting NSCLC Progression 
through the Regulation of Ferroptosis].,2026,10.3779/j.issn.1009-3419.2026.106.23,https://pubmed.ncbi.nlm.nih.gov/42896969/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,41517679,Clinical significance and immune effect of expression of NUF2 in lung adenocarcinoma.,2026,10.1097/md.0000000000046978,https://pubmed.ncbi.nlm.nih.gov/41517679/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,41182432,Elevated NUF2 and CD52 expression predict platinum-based chemoresistance and poor prognosis in non-small cell lung cancer.,2025,10.1007/s12672-025-03809-0,https://pubmed.ncbi.nlm.nih.gov/41182432/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,40890233,Uncovering novel functions of NUF2 in glioblastoma and MRI-based expression prediction.,2025,10.1038/s41598-025-15721-2,https://pubmed.ncbi.nlm.nih.gov/40890233/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,42196147,Uncovering Prognostic Biomarkers Underlying Hepatocellular Carcinoma Through Integrative Multi-Omics and a Network-Based Approach.,2026,10.3390/ijms27104164,https://pubmed.ncbi.nlm.nih.gov/42196147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,41237374,"Immunohistochemical expression of POC1A, NUF2, and Ki-67 in invasive ductal carcinoma of the breast.",2025,10.1093/ajcp/aqaf114,https://pubmed.ncbi.nlm.nih.gov/41237374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,42565514,SKY92 Identifies High-Risk Newly Diagnosed Multiple Myeloma With Inferior Progression-Free Survival and Implicates NUF2 as a Candidate Driver.,2026,10.1111/ejh.70282,https://pubmed.ncbi.nlm.nih.gov/42565514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,42605718,Single-cell multi-omics reveals NUF2 as a potential biomarker associated with the high-lactylation malignant state in osteosarcoma.,2026,10.1177/03936155261465683,https://pubmed.ncbi.nlm.nih.gov/42605718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,41229848,NUF2 promotes the malignant development of lung adenocarcinoma through the mTORC1 signaling pathway via binding to BUB1B.,2025,10.21037/jtd-2025-704,https://pubmed.ncbi.nlm.nih.gov/41229848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,41969031,"Immunohistochemical expression of POC1A, NUF2, and Ki-67 in invasive ductal carcinoma of the breast: prognostic significance with insights into triple-negative breast cancer.",2026,10.1093/ajcp/aqag011,https://pubmed.ncbi.nlm.nih.gov/41969031/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,41569314,"Anti-cancer effects of carvacrol on NUF2, CASP3 and CLDN6 expression in T47D breast cancer cells.",2026,10.1007/s00210-026-05013-5,https://pubmed.ncbi.nlm.nih.gov/41569314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,42492364,Integrative single-cell and machine learning analysis identifies a tumor doubling time-related prognostic signature and therapeutic targets in head and neck squamous cell carcinoma.,2026,10.1016/j.tranon.2026.102927,https://pubmed.ncbi.nlm.nih.gov/42492364/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,40421783,Expression of NUF2 and CD52 and Their Correlation With Chemotherapy Resistance and Prognosis in Patients With Non-Small Cell Lung Cancer.,2025,10.1002/jbt.70308,https://pubmed.ncbi.nlm.nih.gov/40421783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,40582584,USP7-mediated NUF2 deubiquitination accelerates ovarian cancer progression through regulating SLC7A11 expression.,2025,10.1016/j.yexcr.2025.114659,https://pubmed.ncbi.nlm.nih.gov/40582584/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,38472943,NUF2 Expression in Cancer Tissues and Lymph Nodes Suggests Post-Surgery Recurrence of Non-Small Cell Lung Cancer.,2024,10.3390/diagnostics14050471,https://pubmed.ncbi.nlm.nih.gov/38472943/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,42589442,MicroRNA Signatures of Fulvestrant-Treated Luminal Breast Cancer Cells: Identification of Therapeutic Targets Regulated by &lt;i&gt;miR-374b-5p&lt;/i&gt;.,2026,10.3390/ijms27156787,https://pubmed.ncbi.nlm.nih.gov/42589442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,39193700,Targeting NUF2 suppresses gastric cancer progression through G2/M phase arrest and apoptosis induction.,2024,10.1097/cm9.0000000000003006,https://pubmed.ncbi.nlm.nih.gov/39193700/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,39703688,NUF2 is associated with cancer stem cell characteristics and a potential drug target for prostate cancer.,2024,10.3389/fmolb.2024.1481375,https://pubmed.ncbi.nlm.nih.gov/39703688/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,42720478,Structure-Based Design of First Ndc80 Loop-Targeting Peptide Disrupting Ndc80-Nuf2 Interaction for Hepatocellular Carcinoma Therapy.,2026,10.1021/acs.jmedchem.6c01876,https://pubmed.ncbi.nlm.nih.gov/42720478/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,41792761,Multi-omics profiling reveals divergent biology and liver microenvironment in HCC of metastatic and de novo origin.,2026,10.1186/s12943-026-02604-x,https://pubmed.ncbi.nlm.nih.gov/41792761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,39819722,Predictive value of NUF2 for prognosis and immunotherapy responses in pan-cancer.,2025,10.12122/j.issn.1673-4254.2025.01.17,https://pubmed.ncbi.nlm.nih.gov/39819722/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,41373021,"A core stemness-associated module reveals PLK1, NUF2, KIF23, CDCA8, TOP2A, CENPF, AURKA, and ASPM as key genes in rectal cancer.",2025,10.1186/s40001-025-03649-2,https://pubmed.ncbi.nlm.nih.gov/41373021/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,41579174,Sex-dependent transcriptional responses and druggable targets in gentamicin-induced nephrotoxicity.,2026,10.1007/s00210-026-04997-4,https://pubmed.ncbi.nlm.nih.gov/41579174/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,39814554,Roles of the CDCA gene family in breast carcinoma.,2025,10.1177/00368504241312305,https://pubmed.ncbi.nlm.nih.gov/39814554/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,37138262,NUF2 is correlated with a poor prognosis and immune infiltration in clear cell renal cell carcinoma.,2023,10.1186/s12894-023-01258-x,https://pubmed.ncbi.nlm.nih.gov/37138262/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,40220284,NUF2 and NEK2 promote malignant progression of gallbladder cancer by remodeling the extracellular matrix.,2025,10.1093/carcin/bgaf019,https://pubmed.ncbi.nlm.nih.gov/40220284/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,35777029,"Clinical significance and prospective molecular mechanism of NUF2 in gastric cancer exploration: A comprehensive study based on the GeneChip, GEO, Oncomine, and TCGA databases.",2022,10.1097/md.0000000000029802,https://pubmed.ncbi.nlm.nih.gov/35777029/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,38507923,NUF2 regulated the progression of hepatocellular carcinoma through modulating the PI3K/AKT pathway via stabilizing ERBB3.,2024,10.1016/j.tranon.2024.101933,https://pubmed.ncbi.nlm.nih.gov/38507923/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,41184881,HROB is a novel prognostic biomarker correlated with immune cell infiltration and tumor progression in lung adenocarcinoma.,2025,10.1186/s12957-025-04070-z,https://pubmed.ncbi.nlm.nih.gov/41184881/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,40178670,PBK as a novel biomarker performed excellent diagnostic and prognostic value in HCC associated with immune infiltration and methylation.,2025,10.1007/s10735-024-10324-z,https://pubmed.ncbi.nlm.nih.gov/40178670/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,38988558,Comprehensive molecular analyses and experimental validation of CDCAs with potential implications in kidney renal papillary cell carcinoma prognosis.,2024,10.1016/j.heliyon.2024.e33045,https://pubmed.ncbi.nlm.nih.gov/38988558/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUF2,ENSG00000143228,Unsafe,39524538,NUF2 overexpression predicts poor outcomes in multiple myeloma.,2025,10.1016/j.gendis.2024.101268,https://pubmed.ncbi.nlm.nih.gov/39524538/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,41443065,Light-exclusion bagging modulates phenylpropanoid metabolism to balance preharvest quality and postharvest granulation in 'Sanhongmiyou' pomelo.,2026,10.1016/j.foodchem.2025.147675,https://pubmed.ncbi.nlm.nih.gov/41443065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,42488338,Role and insights of human papillomavirus E5 oncoprotein in cervical carcinogenesis.,2026,10.3892/etm.2026.13230,https://pubmed.ncbi.nlm.nih.gov/42488338/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,41002397,Morphological and Transcriptomic Analyses of the Adrenal Gland in &lt;i&gt;Acomys cahirinus&lt;/i&gt;: A Novel Model for Murine Adrenal Physiology.,2025,10.3390/cells14181431,https://pubmed.ncbi.nlm.nih.gov/41002397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,42155730,Proteomic Analysis on Human Islets Suggests Nucleocytoplasmic Transport as a Mechanism of PERK Attenuation Effects in Diabetes.,2026,10.1016/j.mcpro.2026.101588,https://pubmed.ncbi.nlm.nih.gov/42155730/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,40865161,Histone Deacetylase Inhibitors orchestrate epigenetic signalling and alter the nucleoporins and nuclear envelope in cervical cancer.,2025,10.1016/j.tranon.2025.102510,https://pubmed.ncbi.nlm.nih.gov/40865161/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,42412942,HIV-1 capsid interactions with Nuclear Pore Complex components support nuclear entry via affinity gradient.,2026,10.1073/pnas.2534919123,https://pubmed.ncbi.nlm.nih.gov/42412942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,38940394,Preliminary study of identified novel susceptibility loci for HAPE risk in a Chinese male Han population.,2024,10.1080/17410541.2024.2365617,https://pubmed.ncbi.nlm.nih.gov/38940394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,34528284,Non-genetic and genetic rewiring underlie adaptation to hypomorphic alleles of an essential gene.,2021,10.15252/embj.2021107839,https://pubmed.ncbi.nlm.nih.gov/34528284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,37897949,Single-cell transcriptomics uncover hub genes and cell-cell crosstalk in patients with hypertensive nephropathy.,2023,10.1016/j.intimp.2023.111104,https://pubmed.ncbi.nlm.nih.gov/37897949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,30787996,NUP58 facilitates metastasis and epithelial-mesenchymal transition of lung adenocarcinoma via the GSK-3β/Snail signaling pathway.,2019,,https://pubmed.ncbi.nlm.nih.gov/30787996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,36190325,Acetylation of Nup62 by TIP60 ensures accurate chromosome segregation in mitosis.,2022,10.1093/jmcb/mjac056,https://pubmed.ncbi.nlm.nih.gov/36190325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,31388347,Nucleoporin Nup58 localizes to centrosomes and mid-bodies during mitosis.,2019,10.1186/s13008-019-0050-z,https://pubmed.ncbi.nlm.nih.gov/31388347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,37198214,Indel driven rapid evolution of core nuclear pore protein gene promoters.,2023,10.1038/s41598-023-34985-0,https://pubmed.ncbi.nlm.nih.gov/37198214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,33856346,Channel nuclear pore complex subunits are required for transposon silencing in &lt;i&gt;Drosophila&lt;/i&gt;.,2021,10.7554/elife.66321,https://pubmed.ncbi.nlm.nih.gov/33856346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,33049985,Investigating the Transition of Pre-Symptomatic to Symptomatic Huntington's Disease Status Based on Omics Data.,2020,10.3390/ijms21197414,https://pubmed.ncbi.nlm.nih.gov/33049985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,33085133,Molecular and structural analysis of central transport channel in complex with Nup93 of nuclear pore complex.,2020,10.1002/pro.3983,https://pubmed.ncbi.nlm.nih.gov/33085133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,33346731,Conformation of the nuclear pore in living cells is modulated by transport state.,2020,10.7554/elife.60654,https://pubmed.ncbi.nlm.nih.gov/33346731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,35643613,A Nucleoporin NUP58 modulates responses to drought and salt stress in maize (Zea mays L.).,2022,10.1016/j.plantsci.2022.111296,https://pubmed.ncbi.nlm.nih.gov/35643613/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,32060001,Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice.,2020,10.1053/j.gastro.2020.02.011,https://pubmed.ncbi.nlm.nih.gov/32060001/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,25621300,"Cancer driver candidate genes AVL9, DENND5A and NUPL1 contribute to MDCK cystogenesis.",2014,10.18632/oncoscience.107,https://pubmed.ncbi.nlm.nih.gov/25621300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,37239918,Identification of New FG-Repeat Nucleoporins with Amyloid Properties.,2023,10.3390/ijms24108571,https://pubmed.ncbi.nlm.nih.gov/37239918/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP58,ENSG00000139496,Unsafe,29986057,Nucleoporin 54 contributes to homologous recombination repair and post-replicative DNA integrity.,2018,10.1093/nar/gky569,https://pubmed.ncbi.nlm.nih.gov/29986057/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,42288007,NUP62 promotes non-small cell lung cancer progression by enhancing STAT4 nuclear translocation to upregulate CFH transcription.,2026,10.1016/j.tice.2026.103691,https://pubmed.ncbi.nlm.nih.gov/42288007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,42016308,NUP62 promotes breast cancer progression and inhibits ferroptosis by stabilizing NRF2 in a KEAP1-dependent way.,2026,10.1016/j.isci.2026.115484,https://pubmed.ncbi.nlm.nih.gov/42016308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,42185638,Silencing of NUP62 overcomes osimertinib resistance via ubiquitination of survivin in non-small cell lung cancer cells.,2026,10.1038/s41416-026-03475-1,https://pubmed.ncbi.nlm.nih.gov/42185638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,40098960,"Exploring NUP62's role in cancer progression, tumor immunity, and treatment response: insights from multi-omics analysis.",2025,10.3389/fimmu.2025.1559396,https://pubmed.ncbi.nlm.nih.gov/40098960/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,41501594,NUP62 Elevates USP10 Expression and Promotes Tamoxifen Resistance of Breast Cancer by Deubiquitinating ERα.,2026,10.1245/s10434-025-18995-y,https://pubmed.ncbi.nlm.nih.gov/41501594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,40246825,NUP62 alleviates senescence and promotes the stemness of human dental pulp stem cells via NSD2-dependent epigenetic reprogramming.,2025,10.1038/s41368-025-00362-y,https://pubmed.ncbi.nlm.nih.gov/40246825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,41162585,Proteome of seminal plasma and sperm associated with sperm survival following cryopreservation in the Red Wolf (Canis rufus).,2025,10.1038/s41598-025-21778-w,https://pubmed.ncbi.nlm.nih.gov/41162585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,41022737,The pathogen effector BcSSP2 suppresses the NPC phase separation to facilitate Botrytis cinerea infection.,2025,10.1038/s41467-025-63632-7,https://pubmed.ncbi.nlm.nih.gov/41022737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,41510169,Dual targeting of AMRC12 and &lt;i&gt;Malassezia globosa&lt;/i&gt; disrupts MYC liquid condensates-driven nuclear pore complex biogenesis in neuroblastoma.,2026,10.7150/thno.120935,https://pubmed.ncbi.nlm.nih.gov/41510169/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,41274844,Local Delivery of miR-27a* Using Ultrasound-Targeted Microbubble Cavitation Inhibits Squamous Cell Carcinoma Growth.,2026,10.1016/j.ultrasmedbio.2025.10.018,https://pubmed.ncbi.nlm.nih.gov/41274844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,42389530,Distinct IgM and IgG autoantibody profiles characterize incomplete and classified systemic autoimmune diseases.,2026,10.3389/fimmu.2026.1847217,https://pubmed.ncbi.nlm.nih.gov/42389530/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,37998346,Cyclin B Export to the Cytoplasm via the Nup62 Subcomplex and Subsequent Rapid Nuclear Import Are Required for the Initiation of Drosophila Male Meiosis.,2023,10.3390/cells12222611,https://pubmed.ncbi.nlm.nih.gov/37998346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,42613378,Hydrophobic interactions of FG-nucleoporins are required for dilating nuclear membrane pores into selective transport channels after mitosis.,2026,10.1038/s41594-026-01865-w,https://pubmed.ncbi.nlm.nih.gov/42613378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,39536094,Channel width modulates the permeability of DNA origami-based nuclear pore mimics.,2024,10.1126/sciadv.adq8773,https://pubmed.ncbi.nlm.nih.gov/39536094/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,36845732,Overexpressed Nup88 stabilized through interaction with Nup62 promotes NF-κB dependent pathways in cancer.,2023,10.3389/fonc.2023.1095046,https://pubmed.ncbi.nlm.nih.gov/36845732/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,39602452,Coronavirus nucleocapsid protein enhances the binding of p-PKCα to RACK1: Implications for inhibition of nucleocytoplasmic trafficking and suppression of the innate immune response.,2024,10.1371/journal.ppat.1012097,https://pubmed.ncbi.nlm.nih.gov/39602452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,35697676,NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility.,2022,10.1038/s41467-022-31098-6,https://pubmed.ncbi.nlm.nih.gov/35697676/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,36482422,Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy.,2022,10.1186/s13024-022-00585-1,https://pubmed.ncbi.nlm.nih.gov/36482422/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,38396708,Exploring the Importance of Differential Expression of Autophagy Markers in Term Placentas from Late-Onset Preeclamptic Pregnancies.,2024,10.3390/ijms25042029,https://pubmed.ncbi.nlm.nih.gov/38396708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,37643521,Morphometric similarity network alterations in COVID-19 survivors correlate with behavioral features and transcriptional signatures.,2023,10.1016/j.nicl.2023.103498,https://pubmed.ncbi.nlm.nih.gov/37643521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,38660294,A three-gene expression score for predicting clinical benefit to anti-PD-1 blockade in advanced renal cell carcinoma.,2024,10.3389/fimmu.2024.1374728,https://pubmed.ncbi.nlm.nih.gov/38660294/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,42049205,A de novo C-terminal truncation mutation in NUP205 as a key factor in premature ovarian insufficiency.,2026,10.1093/humrep/deag068,https://pubmed.ncbi.nlm.nih.gov/42049205/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,39175083,Vildagliptin promotes diabetic foot ulcer healing through autophagy modulation.,2024,10.1186/s13098-024-01444-3,https://pubmed.ncbi.nlm.nih.gov/39175083/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,34629889,Nuclear Pore Glycoprotein 62 Genetic Variant rs9523 is Associated with Clinical Outcomes of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung Adenocarcinoma Patients.,2021,10.2147/pgpm.s329055,https://pubmed.ncbi.nlm.nih.gov/34629889/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,34060470,Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology.,2021,10.7554/elife.67587,https://pubmed.ncbi.nlm.nih.gov/34060470/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,36936942,"""From molecular to clinic"": The pivotal role of CDC42 in pathophysiology of human papilloma virus related cancers and a correlated sensitivity of afatinib.",2023,10.3389/fimmu.2023.1118458,https://pubmed.ncbi.nlm.nih.gov/36936942/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,36189423,Functional high-throughput screen identifies microRNAs that promote butyrate-induced death in colorectal cancer cells.,2022,10.1016/j.omtn.2022.08.037,https://pubmed.ncbi.nlm.nih.gov/36189423/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,32483230,Nuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus.,2020,10.1038/s41564-020-0735-8,https://pubmed.ncbi.nlm.nih.gov/32483230/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,25605329,Nucleoporin 62-like protein activates canonical Wnt signaling through facilitating the nuclear import of β-catenin in zebrafish.,2015,10.1128/mcb.01181-14,https://pubmed.ncbi.nlm.nih.gov/25605329/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,30084827,Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.,2018,10.7554/elife.35738,https://pubmed.ncbi.nlm.nih.gov/30084827/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,25264252,An assay for clogging the ciliary pore complex distinguishes mechanisms of cytosolic and membrane protein entry.,2014,10.1016/j.cub.2014.08.012,https://pubmed.ncbi.nlm.nih.gov/25264252/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,22308026,Contribution of host nucleoporin 62 in HIV-1 integrase chromatin association and viral DNA integration.,2012,10.1074/jbc.m111.317057,https://pubmed.ncbi.nlm.nih.gov/22308026/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,29986057,Nucleoporin 54 contributes to homologous recombination repair and post-replicative DNA integrity.,2018,10.1093/nar/gky569,https://pubmed.ncbi.nlm.nih.gov/29986057/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,28040728,Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD.,2017,10.1093/hmg/ddw432,https://pubmed.ncbi.nlm.nih.gov/28040728/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62,ENSG00000213024,Unsafe,24825433,CAMK1 phosphoinositide signal-mediated protein sorting and transport network in human hepatocellular carcinoma (HCC) by biocomputation.,2014,10.1007/s12013-014-0011-8,https://pubmed.ncbi.nlm.nih.gov/24825433/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62CL,ENSG00000198088,Unsafe,37663758,NUP62CL as an Immunological and Prognostic Biomarker of Oral Squamous Cell Carcinoma.,2023,10.2147/jir.s426277,https://pubmed.ncbi.nlm.nih.gov/37663758/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62CL,ENSG00000198088,Unsafe,39720592,NUP155 and NDC1 interaction in NSCLC: a promising target for tumor progression.,2024,10.3389/fphar.2024.1514367,https://pubmed.ncbi.nlm.nih.gov/39720592/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62CL,ENSG00000198088,Unsafe,33934535,The low expression of NUP62CL indicates good prognosis and high level of immune infiltration in lung adenocarcinoma.,2021,10.1002/cam4.3877,https://pubmed.ncbi.nlm.nih.gov/33934535/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62CL,ENSG00000198088,Unsafe,37532906,Comprehensive analysis of resistance mechanisms to EGFR-TKIs and establishment and validation of prognostic model.,2023,10.1007/s00432-023-05129-8,https://pubmed.ncbi.nlm.nih.gov/37532906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62CL,ENSG00000198088,Unsafe,31492028,Nucleoporin 62-Like Protein is Required for the Development of Pharyngeal Arches through Regulation of Wnt/β-Catenin Signaling and Apoptotic Homeostasis in Zebrafish.,2019,10.3390/cells8091038,https://pubmed.ncbi.nlm.nih.gov/31492028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62CL,ENSG00000198088,Unsafe,36505295,Identification of candidate miRNA biomarkers correlated with the prognosis of cell carcinoma and endocervical adenocarcinoma via integrated bioinformatics analysis.,2022,,https://pubmed.ncbi.nlm.nih.gov/36505295/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUP62CL,ENSG00000198088,Unsafe,25605329,Nucleoporin 62-like protein activates canonical Wnt signaling through facilitating the nuclear import of β-catenin in zebrafish.,2015,10.1128/mcb.01181-14,https://pubmed.ncbi.nlm.nih.gov/25605329/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUPR2,ENSG00000185290,Unsafe,41730952,Effects of testosterone on gene expression in males and females across 40 human tissues.,2026,10.1038/s41598-026-40863-2,https://pubmed.ncbi.nlm.nih.gov/41730952/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUPR2,ENSG00000185290,Unsafe,41006764,Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage.,2026,10.1038/s41380-025-03272-x,https://pubmed.ncbi.nlm.nih.gov/41006764/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUPR2,ENSG00000185290,Unsafe,36858171,Intrinsically Disordered Chromatin Protein NUPR1 Binds to the Enzyme PADI4.,2023,10.1016/j.jmb.2023.168033,https://pubmed.ncbi.nlm.nih.gov/36858171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUPR2,ENSG00000185290,Unsafe,33050086,The Paralogue of the Intrinsically Disordered Nuclear Protein 1 Has a Nuclear Localization Sequence that Binds to Human Importin α3.,2020,10.3390/ijms21197428,https://pubmed.ncbi.nlm.nih.gov/33050086/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUPR2,ENSG00000185290,Unsafe,25899918,"Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1.",2015,10.1002/jcp.25022,https://pubmed.ncbi.nlm.nih.gov/25899918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUPR2,ENSG00000185290,Unsafe,29925531,The chromatin nuclear protein NUPR1L is intrinsically disordered and binds to the same proteins as its paralogue.,2018,10.1042/bcj20180365,https://pubmed.ncbi.nlm.nih.gov/29925531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUPR2,ENSG00000185290,Unsafe,32140072,Functional Passenger-Strand miRNAs in Exosomes Derived from Human Colon Cancer Cells and Their Heterogeneous Paracrine Effects.,2020,10.7150/ijbs.40787,https://pubmed.ncbi.nlm.nih.gov/32140072/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUPR2,ENSG00000185290,Unsafe,25056123,"Evidence supporting the existence of a NUPR1-like family of helix-loop-helix chromatin proteins related to, yet distinct from, AT hook-containing HMG proteins.",2014,10.1007/s00894-014-2357-7,https://pubmed.ncbi.nlm.nih.gov/25056123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM2F,ENSG00000130950,Unsafe,37231433,Molecular profiling of a real-world breast cancer cohort with genetically inferred ancestries reveals actionable tumor biology differences between European ancestry and African ancestry patient populations.,2023,10.1186/s13058-023-01627-2,https://pubmed.ncbi.nlm.nih.gov/37231433/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM2F,ENSG00000130950,Unsafe,32764209,Host Genetic and Gut Microbial Signatures in Familial Inflammatory Bowel Disease.,2020,10.14309/ctg.0000000000000213,https://pubmed.ncbi.nlm.nih.gov/32764209/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM2F,ENSG00000130950,Unsafe,30362198,Comprehensive analysis of coexpressed long noncoding RNAs and genes in breast cancer.,2019,10.1111/jog.13840,https://pubmed.ncbi.nlm.nih.gov/30362198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NUTM2F,ENSG00000130950,Unsafe,25038616,Expression profiling of genes modulated by minocycline in a rat model of neuropathic pain.,2014,10.1186/1744-8069-10-47,https://pubmed.ncbi.nlm.nih.gov/25038616/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,40624043,NXT2 is a key component of the RNA nuclear export factor complex in the human testis and essential for spermatogenesis.,2025,10.1038/s41467-025-61463-0,https://pubmed.ncbi.nlm.nih.gov/40624043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,36548300,Safeguarding Drosophila female germ cell identity depends on an H3K9me3 mini domain guided by a ZAD zinc finger protein.,2022,10.1371/journal.pgen.1010568,https://pubmed.ncbi.nlm.nih.gov/36548300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,35192609,Lrh1 can help reprogram sexual cell fate and is required for Sertoli cell development and spermatogenesis in the mouse testis.,2022,10.1371/journal.pgen.1010088,https://pubmed.ncbi.nlm.nih.gov/35192609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,33347429,Telomeric TART elements target the piRNA machinery in Drosophila.,2020,10.1371/journal.pbio.3000689,https://pubmed.ncbi.nlm.nih.gov/33347429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,34337769,Piwi-piRNA complexes induce stepwise changes in nuclear architecture at target loci.,2021,10.15252/embj.2021108345,https://pubmed.ncbi.nlm.nih.gov/34337769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,31368590,Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing.,2019,10.15252/embj.2019102870,https://pubmed.ncbi.nlm.nih.gov/31368590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,31219034,piRNA-guided co-transcriptional silencing coopts nuclear export factors.,2019,10.7554/elife.47999,https://pubmed.ncbi.nlm.nih.gov/31219034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,31384064,The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.,2019,10.1038/s41594-019-0270-6,https://pubmed.ncbi.nlm.nih.gov/31384064/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,24002123,The cancer‑testis antigen NXF2 is activated by the hypomethylating agent decitabine in acute leukemia cells in vitro and in vivo.,2013,10.3892/mmr.2013.1659,https://pubmed.ncbi.nlm.nih.gov/24002123/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,23675524,Generation and characterization of an Nxf7 knockout mouse to study NXF5 deficiency in a patient with intellectual disability.,2013,10.1371/journal.pone.0064144,https://pubmed.ncbi.nlm.nih.gov/23675524/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,28342986,Oncogenic roles of DNA hypomethylation through the activation of cancer-germline genes.,2017,10.1016/j.canlet.2017.03.029,https://pubmed.ncbi.nlm.nih.gov/28342986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,21308854,"Nxf3 is expressed in Sertoli cells, but is dispensable for spermatogenesis.",2011,10.1002/mrd.21291,https://pubmed.ncbi.nlm.nih.gov/21308854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,23677977,A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice.,2013,10.1095/biolreprod.112.106963,https://pubmed.ncbi.nlm.nih.gov/23677977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,19345203,Inactivation of Nxf2 causes defects in male meiosis and age-dependent depletion of spermatogonia.,2009,10.1016/j.ydbio.2009.03.022,https://pubmed.ncbi.nlm.nih.gov/19345203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,27705943,"Copy number gain of VCX, X-linked multi-copy gene, leads to cell proliferation and apoptosis during spermatogenesis.",2016,10.18632/oncotarget.12397,https://pubmed.ncbi.nlm.nih.gov/27705943/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,33538693,Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in &lt;i&gt;Drosophila&lt;/i&gt;.,2021,10.7554/elife.65557,https://pubmed.ncbi.nlm.nih.gov/33538693/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,24795360,Cancer-testis antigen expression in digestive tract carcinomas: frequent expression in esophageal squamous cell carcinoma and its precursor lesions.,2014,10.1158/2326-6066.cir-13-0124,https://pubmed.ncbi.nlm.nih.gov/24795360/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,17548835,Fragile X mental retardation protein FMRP and the RNA export factor NXF2 associate with and destabilize Nxf1 mRNA in neuronal cells.,2007,10.1073/pnas.0700169104,https://pubmed.ncbi.nlm.nih.gov/17548835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,16790844,The fragile X mental retardation protein interacts with a distinct mRNA nuclear export factor NXF2.,2006,10.1261/rna.94306,https://pubmed.ncbi.nlm.nih.gov/16790844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,18258234,Is there a role for the nuclear export factor 2 gene in male infertility?,2008,10.1016/j.fertnstert.2007.08.071,https://pubmed.ncbi.nlm.nih.gov/18258234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,19401350,"Treatment of chronic lymphocytic leukemia with a hypomethylating agent induces expression of NXF2, an immunogenic cancer testis antigen.",2009,10.1158/1078-0432.ccr-08-2099,https://pubmed.ncbi.nlm.nih.gov/19401350/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,21437249,Multiple cancer/testis antigens are preferentially expressed in hormone-receptor negative and high-grade breast cancers.,2011,10.1371/journal.pone.0017876,https://pubmed.ncbi.nlm.nih.gov/21437249/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,22869527,Multiple cancer testis antigens function to support tumor cell mitotic fidelity.,2012,10.1128/mcb.00686-12,https://pubmed.ncbi.nlm.nih.gov/22869527/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,16027110,Identification and characterization of the mouse nuclear export factor (Nxf) family members.,2005,10.1093/nar/gki706,https://pubmed.ncbi.nlm.nih.gov/16027110/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2,ENSG00000269405,Unsafe,12704671,Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia.,2003,10.1002/ijc.11104,https://pubmed.ncbi.nlm.nih.gov/12704671/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2B,ENSG00000269437,Unsafe,37758722,Comprehensive analysis of TLX2 in pan cancer as a prognostic and immunologic biomarker and validation in ovarian cancer.,2023,10.1038/s41598-023-42171-5,https://pubmed.ncbi.nlm.nih.gov/37758722/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF2B,ENSG00000269437,Unsafe,12704671,Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia.,2003,10.1002/ijc.11104,https://pubmed.ncbi.nlm.nih.gov/12704671/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,40624043,NXT2 is a key component of the RNA nuclear export factor complex in the human testis and essential for spermatogenesis.,2025,10.1038/s41467-025-61463-0,https://pubmed.ncbi.nlm.nih.gov/40624043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,40032765,Nuclear translocation of CDK5RAP3 regulated by NXF3 promotes the progression of gastric cancer.,2025,10.1007/s00018-025-05630-y,https://pubmed.ncbi.nlm.nih.gov/40032765/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,42166010,Lentiviral-mediated expression of cytochrome P450 2D6 in HepaRG cells: new means for in vitro xenobiotic biotransformation and cellular response to chimeric viral mRNA.,2026,10.1007/s00204-026-04453-5,https://pubmed.ncbi.nlm.nih.gov/42166010/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,38452974,Transcriptomic analysis to identify genes associated with hypothalamus vulnerability in aging mice with cognitive decline.,2024,10.1016/j.bbr.2024.114943,https://pubmed.ncbi.nlm.nih.gov/38452974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,36617979,Detection of aberrant DNA methylation patterns in sperm of male recurrent spontaneous abortion patients.,2023,10.1017/s0967199422000648,https://pubmed.ncbi.nlm.nih.gov/36617979/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,31416967,Specialization of the &lt;i&gt;Drosophila&lt;/i&gt; nuclear export family protein Nxf3 for piRNA precursor export.,2019,10.1101/gad.328690.119,https://pubmed.ncbi.nlm.nih.gov/31416967/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,21308854,"Nxf3 is expressed in Sertoli cells, but is dispensable for spermatogenesis.",2011,10.1002/mrd.21291,https://pubmed.ncbi.nlm.nih.gov/21308854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,29021253,Nuclear export factor 3 regulates localization of small nucleolar RNAs.,2017,10.1074/jbc.m117.818146,https://pubmed.ncbi.nlm.nih.gov/29021253/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,29274323,AF119895 regulates NXF3 expression to promote migration and invasion of hepatocellular carcinoma through an interaction with miR-6508-3p.,2018,10.1016/j.yexcr.2017.12.016,https://pubmed.ncbi.nlm.nih.gov/29274323/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,23438076,Nuclear export factor 3 is involved in regulating the expression of TGF-β3 in an mRNA export activity-independent manner in mouse Sertoli cells.,2013,10.1042/bj20121006,https://pubmed.ncbi.nlm.nih.gov/23438076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,24520286,Prognostic significance of nuclear RNA export factor 3 in hepatocellular carcinoma.,2014,10.3892/ol.2014.1809,https://pubmed.ncbi.nlm.nih.gov/24520286/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,23677977,A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice.,2013,10.1095/biolreprod.112.106963,https://pubmed.ncbi.nlm.nih.gov/23677977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,30611221,Anti-cancer effect of dung beetle glycosaminoglycans on melanoma.,2019,10.1186/s12885-018-5202-z,https://pubmed.ncbi.nlm.nih.gov/30611221/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,24569167,"Respiratory failure, cleft palate and epilepsy in the mouse model of human Xq22.1 deletion syndrome.",2014,10.1093/hmg/ddu095,https://pubmed.ncbi.nlm.nih.gov/24569167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,28427776,Autoantibody biomarkers for the detection of serous ovarian cancer.,2017,10.1016/j.ygyno.2017.04.005,https://pubmed.ncbi.nlm.nih.gov/28427776/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,19345203,Inactivation of Nxf2 causes defects in male meiosis and age-dependent depletion of spermatogonia.,2009,10.1016/j.ydbio.2009.03.022,https://pubmed.ncbi.nlm.nih.gov/19345203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,24209690,An X-chromosomal association study identifies a susceptibility locus at Xq22.1 for hepatitis B virus-related hepatocellular carcinoma.,2013,10.1016/j.clinre.2013.09.002,https://pubmed.ncbi.nlm.nih.gov/24209690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,15820316,Molecular cloning and functional characterization of mouse Nxf family gene products.,2005,10.1016/j.ygeno.2005.01.003,https://pubmed.ncbi.nlm.nih.gov/15820316/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,28800944,Systematic review: Tumor-associated antigen autoantibodies and ovarian cancer early detection.,2017,10.1016/j.ygyno.2017.07.138,https://pubmed.ncbi.nlm.nih.gov/28800944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
NXF3,ENSG00000147206,Unsafe,17403691,NXF2 is involved in cytoplasmic mRNA dynamics through interactions with motor proteins.,2007,10.1093/nar/gkm125,https://pubmed.ncbi.nlm.nih.gov/17403691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,42035449,Serum Proteomic Analysis Using Gel-Based Liquid Chromatography Tandem Mass Spectrometry Reveals Differences Between Canine Oral Malignancies and Non-Malignant Conditions.,2026,10.1002/vms3.70956,https://pubmed.ncbi.nlm.nih.gov/42035449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,41931169,Ubiquitously expressed prefoldin-like chaperone (UXT) regulates putrescine metabolism and promotes colorectal cancer progression.,2026,10.1007/s13577-026-01364-6,https://pubmed.ncbi.nlm.nih.gov/41931169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,39506588,Identification of Potential Biomarkers Associated with Spermatogenesis in Azoospermia.,2024,10.7754/clin.lab.2024.240541,https://pubmed.ncbi.nlm.nih.gov/39506588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,30566531,New insights of polyamine metabolism in testicular physiology: A role of ornithine decarboxylase antizyme inhibitor 2 (AZIN2) in the modulation of testosterone levels and sperm motility.,2018,10.1371/journal.pone.0209202,https://pubmed.ncbi.nlm.nih.gov/30566531/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,37382810,Testicular Toxicity in Rats Exposed to AlCl3: a Proteomics Study.,2024,10.1007/s12011-023-03745-6,https://pubmed.ncbi.nlm.nih.gov/37382810/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,37662841,Identification of crucial modules and genes associated with backfat tissue development by WGCNA in Ningxiang pigs.,2023,10.3389/fgene.2023.1234757,https://pubmed.ncbi.nlm.nih.gov/37662841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,30362892,Expression analysis of a panel of cancer-testis antigens in bladder cancer.,2018,10.2217/pme-2018-0049,https://pubmed.ncbi.nlm.nih.gov/30362892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,35015293,Histone Methylation Regulates Gene Expression in the Round Spermatids to Set the RNA Payloads of Sperm.,2022,10.1007/s43032-021-00837-3,https://pubmed.ncbi.nlm.nih.gov/35015293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,21712390,Ornithine decarboxylase antizyme Oaz3 modulates protein phosphatase activity.,2011,10.1074/jbc.m111.274647,https://pubmed.ncbi.nlm.nih.gov/21712390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,33292187,A systems biology framework integrating GWAS and RNA-seq to shed light on the molecular basis of sperm quality in swine.,2020,10.1186/s12711-020-00592-0,https://pubmed.ncbi.nlm.nih.gov/33292187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,29654272,Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia.,2018,10.1038/s41375-018-0110-4,https://pubmed.ncbi.nlm.nih.gov/29654272/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,17040916,Mammalian transcription in support of hybrid mRNA and protein synthesis in testis and lung.,2006,10.1074/jbc.m606010200,https://pubmed.ncbi.nlm.nih.gov/17040916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,29601948,"Microarray analysis of obese women with polycystic ovary syndrome for key gene screening, key pathway identification and drug prediction.",2018,10.1016/j.gene.2018.03.079,https://pubmed.ncbi.nlm.nih.gov/29601948/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,19893612,OAZ-t/OAZ3 is essential for rigid connection of sperm tails to heads in mouse.,2009,10.1371/journal.pgen.1000712,https://pubmed.ncbi.nlm.nih.gov/19893612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,30923649,Comparative analysis of the liver transcriptome in the red-eared slider Trachemys scripta elegans under chronic salinity stress.,2019,10.7717/peerj.6538,https://pubmed.ncbi.nlm.nih.gov/30923649/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,16542438,"Identification of polymorphisms and balancing selection in the male infertility candidate gene, ornithine decarboxylase antizyme 3.",2006,10.1186/1471-2350-7-27,https://pubmed.ncbi.nlm.nih.gov/16542438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,12426106,Structure and promoter activity of the gene encoding ornithine decarboxylase antizyme expressed exclusively in haploid germ cells in testis (OAZt/Oaz3).,2002,10.1016/s0378-1119(02)00978-2,https://pubmed.ncbi.nlm.nih.gov/12426106/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,27074718,Effects of agmatine on secretion of interferon tau and catecholamines and expression of genes related to production of polyamines by ovine trophectoderm cells.,2016,10.1007/s00726-016-2216-1,https://pubmed.ncbi.nlm.nih.gov/27074718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,15642376,"Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1.",2005,10.1016/j.febslet.2004.10.112,https://pubmed.ncbi.nlm.nih.gov/15642376/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OAZ3,ENSG00000143450,Unsafe,29696996,A technical assessment of the porcine ejaculated spermatozoa for a sperm-specific RNA-seq analysis.,2018,10.1080/19396368.2018.1464610,https://pubmed.ncbi.nlm.nih.gov/29696996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,41916967,Loss-of-function variants in ODAD1 disrupt ODA docking and induce actin cytoskeletal remodeling in primary ciliary dyskinesia.,2026,10.1038/s41421-026-00875-8,https://pubmed.ncbi.nlm.nih.gov/41916967/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,40783954,[Clinical and genetic analysis of a case of Kartagener syndrome with obstructive azoospermia induced by biallelic variation of CCDC114].,2025,,https://pubmed.ncbi.nlm.nih.gov/40783954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,35163670,Expression of a Truncated Form of ODAD1 Associated with an Unusually Mild Primary Ciliary Dyskinesia Phenotype.,2022,10.3390/ijms23031753,https://pubmed.ncbi.nlm.nih.gov/35163670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,38028630,ODAD1 variants resulting from splice-site mutations retain partial function and cause primary ciliary dyskinesia with outer dynein arm defects.,2023,10.3389/fgene.2023.1270278,https://pubmed.ncbi.nlm.nih.gov/38028630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,42351650,A Gene Feature Based on Histone Modifications Can Predict the Prognosis of Prostate Cancer.,2026,10.3390/biomedicines14061219,https://pubmed.ncbi.nlm.nih.gov/42351650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,32855706,Identification of a CCDC114 variant in a Han-Chinese patient with situs inversus.,2020,10.3892/etm.2020.9059,https://pubmed.ncbi.nlm.nih.gov/32855706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,34116668,"CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium.",2021,10.1186/s12905-020-01156-6,https://pubmed.ncbi.nlm.nih.gov/34116668/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,35343062,Primary ciliary dyskinesia in Volendam: Diagnostic and phenotypic features in patients with a CCDC114 mutation.,2022,10.1002/ajmg.c.31968,https://pubmed.ncbi.nlm.nih.gov/35343062/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,35729109,Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening.,2022,10.1038/s41419-022-05010-5,https://pubmed.ncbi.nlm.nih.gov/35729109/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,38871375,Analyses of 1236 genotyped primary ciliary dyskinesia individuals identify regional clusters of distinct DNA variants and significant genotype-phenotype correlations.,2024,10.1183/13993003.01769-2023,https://pubmed.ncbi.nlm.nih.gov/38871375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,30291279,"CCDC114 is mutated in patient with a complex phenotype combining primary ciliary dyskinesia, sensorineural deafness, and renal disease.",2019,10.1038/s10038-018-0514-z,https://pubmed.ncbi.nlm.nih.gov/30291279/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,30148830,Homozygous loss-of-function mutations in MNS1 cause laterality defects and likely male infertility.,2018,10.1371/journal.pgen.1007602,https://pubmed.ncbi.nlm.nih.gov/30148830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,23261303,Splice-site mutations in the axonemal outer dynein arm docking complex gene CCDC114 cause primary ciliary dyskinesia.,2013,10.1016/j.ajhg.2012.11.002,https://pubmed.ncbi.nlm.nih.gov/23261303/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,34280480,Different combinations of high-frequency rTMS and cognitive training improve the cognitive function of cerebral ischemic rats.,2021,10.1016/j.brainresbull.2021.07.012,https://pubmed.ncbi.nlm.nih.gov/34280480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,33305042,"Overlapping variants in the blood, tissues and cell lines for patients with intracranial meningiomas are predominant in stem cell-related genes.",2020,10.1016/j.heliyon.2020.e05632,https://pubmed.ncbi.nlm.nih.gov/33305042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,36714547,High-throughput proteomic characterization of seminal plasma from bulls with contrasting semen quality.,2023,10.1007/s13205-023-03474-6,https://pubmed.ncbi.nlm.nih.gov/36714547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,27486780,TTC25 Deficiency Results in Defects of the Outer Dynein Arm Docking Machinery and Primary Ciliary Dyskinesia with Left-Right Body Asymmetry Randomization.,2016,10.1016/j.ajhg.2016.06.014,https://pubmed.ncbi.nlm.nih.gov/27486780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,34676774,Deep characterization of paired chromatin and transcriptomes in four immune cell types from multiple sclerosis patients.,2021,10.2217/epi-2021-0205,https://pubmed.ncbi.nlm.nih.gov/34676774/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,23261302,Exome sequencing identifies mutations in CCDC114 as a cause of primary ciliary dyskinesia.,2013,10.1016/j.ajhg.2012.11.003,https://pubmed.ncbi.nlm.nih.gov/23261302/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD1,ENSG00000105479,Unsafe,33635012,Genetic Analysis of Korean Adult Patients with Nontuberculous Mycobacteria Suspected of Primary Ciliary Dyskinesia Using Whole Exome Sequencing.,2021,10.3349/ymj.2021.62.3.224,https://pubmed.ncbi.nlm.nih.gov/33635012/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,42325438,Novel pathogenic variant in &lt;i&gt;ARMC4&lt;/i&gt; identified by whole exome sequencing in a Turkish family with primary ciliary dyskinesia.,2026,10.3389/fmolb.2026.1815627,https://pubmed.ncbi.nlm.nih.gov/42325438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,41626619,Papillary urothelial tumor of low malignant potential in a pediatric patient: case associated with Poland syndrome.,2026,10.1016/j.eucr.2026.103348,https://pubmed.ncbi.nlm.nih.gov/41626619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,35269880,Using VBIM Technique to Discover ARMC4/ODAD2 as a Novel Negative Regulator of NF-κB and a New Tumor Suppressor in Colorectal Cancer.,2022,10.3390/ijms23052732,https://pubmed.ncbi.nlm.nih.gov/35269880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,40591047,Identification of key biomarkers and potential therapeutic drugs in nasopharyngeal carcinoma based on comprehensive bioinformatics analysis.,2025,10.1007/s12672-025-03047-4,https://pubmed.ncbi.nlm.nih.gov/40591047/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,40142748,Diagnostic Role of Immunofluorescence Analysis in Primary Ciliary Dyskinesia-Suspected Individuals.,2025,10.3390/jcm14061941,https://pubmed.ncbi.nlm.nih.gov/40142748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,42278892,Prolonged Infections and Inflammatory Diseases in Common Variable Immune Deficiency as a Cause of AA Amyloidosis.,2026,10.3390/jcm15114030,https://pubmed.ncbi.nlm.nih.gov/42278892/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,42071944,Molecular Sex Determination in Caenophidian Snakes Using qPCR Amplification of Sex-Linked Genes: Validation and Interspecific Comparison.,2026,10.3390/ani16081175,https://pubmed.ncbi.nlm.nih.gov/42071944/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,38884051,Unraveling the Genetic Basis of Combined Deafness and Male Infertility Phenotypes through High-Throughput Sequencing in a Unique Cohort from South India.,2024,10.1002/ggn2.202300206,https://pubmed.ncbi.nlm.nih.gov/38884051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,38203325,Genetic Alterations of NF-κB and Its Regulators: A Rich Platform to Advance Colorectal Cancer Diagnosis and Treatment.,2023,10.3390/ijms25010154,https://pubmed.ncbi.nlm.nih.gov/38203325/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,37833735,Outer dynein arm docking complex subunit 2 polymorphism rs7893462 modulates hepatocellular carcinoma susceptibility and can serve as an overall survival biomarker for hepatitis B virus-related hepatocellular carcinoma after hepatectomy: a cohort study with a long-term follow-up.,2023,10.1186/s12957-023-03205-4,https://pubmed.ncbi.nlm.nih.gov/37833735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,37057896,Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrates.,2023,10.7554/elife.84860,https://pubmed.ncbi.nlm.nih.gov/37057896/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,34394199,Case Report: Novel Biallelic Mutations in ARMC4 Cause Primary Ciliary Dyskinesia and Male Infertility in a Chinese Family.,2021,10.3389/fgene.2021.715339,https://pubmed.ncbi.nlm.nih.gov/34394199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,39004484,Prenatal diagnosis of a de novo 10p12.1p11.23 microdeletion encompassing the WAC gene in a fetus associated with bilateral hydronephrosis and right clubfoot on prenatal ultrasound.,2024,10.1016/j.tjog.2024.05.008,https://pubmed.ncbi.nlm.nih.gov/39004484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,35637434,Key gene network related to primary ciliary dyskinesia in hippocampus of patients with Alzheimer's disease revealed by weighted gene co-expression network analysis.,2022,10.1186/s12883-022-02724-z,https://pubmed.ncbi.nlm.nih.gov/35637434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,39104315,Obesity impairs ciliary function and mucociliary clearance in the murine airway epithelium.,2024,10.1152/ajplung.00114.2024,https://pubmed.ncbi.nlm.nih.gov/39104315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,33790390,A practical method to screen and identify functioning biomarkers in nasopharyngeal carcinoma.,2021,10.1038/s41598-021-86809-8,https://pubmed.ncbi.nlm.nih.gov/33790390/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,36159986,Subtyping children with asthma by clustering analysis of mRNA expression data.,2022,10.3389/fgene.2022.974936,https://pubmed.ncbi.nlm.nih.gov/36159986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,34294833,Identification of prognostic alternative splicing events in sarcoma.,2021,10.1038/s41598-021-94485-x,https://pubmed.ncbi.nlm.nih.gov/34294833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,34349594,The Relationship between Genotype and Phenotype in Primary Ciliary Dyskinesia Patients.,2021,10.14744/semb.2020.22567,https://pubmed.ncbi.nlm.nih.gov/34349594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,36882550,Special transcriptome landscape and molecular prognostic signature of non-smoking head and neck cancer patients.,2023,10.1007/s10142-023-01002-6,https://pubmed.ncbi.nlm.nih.gov/36882550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,26330360,Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma.,2015,10.1038/srep13750,https://pubmed.ncbi.nlm.nih.gov/26330360/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,22258158,Deletion at chromosome 10p11.23-p12.1 defines characteristic phenotypes with marked midface retrusion.,2012,10.1038/jhg.2011.154,https://pubmed.ncbi.nlm.nih.gov/22258158/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODAD2,ENSG00000169126,Unsafe,23849778,ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry.,2013,10.1016/j.ajhg.2013.06.009,https://pubmed.ncbi.nlm.nih.gov/23849778/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,42690554,Pan-cancer analysis identifies ODF2 as a dual prognostic and predictive biomarker for immunotherapy.,2026,10.1007/s12672-026-05694-7,https://pubmed.ncbi.nlm.nih.gov/42690554/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,42886617,A novel homozygous missense ODF2 variant in infertile siblings with multiple morphological abnormalities of the sperm flagella.,2026,10.4103/aja202627,https://pubmed.ncbi.nlm.nih.gov/42886617/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,41467448,Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin.,2026,10.1002/1878-0261.70186,https://pubmed.ncbi.nlm.nih.gov/41467448/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,41595442,Nanopore Sequencing Technology Reveals the Transcriptional Expression Characteristics of Male Pig's Testes Before and After Sexual Maturity.,2025,10.3390/genes17010021,https://pubmed.ncbi.nlm.nih.gov/41595442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,42602968,The Odf2 status contributes to asymmetric inheritance of CD133-positive recycling endosomes during cytokinesis in SK-N-DZ human neuroblastoma cells.,2026,10.1016/j.isci.2026.117062,https://pubmed.ncbi.nlm.nih.gov/42602968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,42181678,Long-term cytokine exposure remodels the methylome and transcriptome of recessive dystrophic epidermolysis bullosa keratinocytes - a bioinformatic analysis.,2026,10.3389/fcell.2026.1810599,https://pubmed.ncbi.nlm.nih.gov/42181678/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,40649876,Age-Associated Proteomic Changes in Human Spermatozoa.,2025,10.3390/ijms26136099,https://pubmed.ncbi.nlm.nih.gov/40649876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,39864486,Dual role of Xenopus Odf2 in multiciliated cell patterning and differentiation.,2025,10.1016/j.ydbio.2025.01.014,https://pubmed.ncbi.nlm.nih.gov/39864486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,40137503,Oxidative and Molecular-Structural Alterations of Spermatozoa in Swine and Ram Exposed to the Triazole Ipconazole.,2025,10.3390/toxics13030176,https://pubmed.ncbi.nlm.nih.gov/40137503/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,36251028,Peptide vaccine from cancer-testis antigen ODF2 can potentiate the cytotoxic T lymphocyte infiltration through IL-15 in non-MSI-H colorectal cancer.,2023,10.1007/s00262-022-03307-0,https://pubmed.ncbi.nlm.nih.gov/36251028/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,37681926,ODF2 Negatively Regulates CP110 Levels at the Centrioles/Basal Bodies to Control the Biogenesis of Primary Cilia.,2023,10.3390/cells12172194,https://pubmed.ncbi.nlm.nih.gov/37681926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,37198331,BBOF1 is required for sperm motility and male fertility by stabilizing the flagellar axoneme in mice.,2023,10.1007/s00018-023-04800-0,https://pubmed.ncbi.nlm.nih.gov/37198331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,37838951,[Impacts of ODF2 gene knockdown on the sperm motility and fertility of male mice].,2022,,https://pubmed.ncbi.nlm.nih.gov/37838951/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,36709584,Specific expression of alternatively spliced genes in the turkey (Meleagris gallopavo) reproductive tract revealed their function in spermatogenesis and post-testicular sperm maturation.,2023,10.1016/j.psj.2023.102484,https://pubmed.ncbi.nlm.nih.gov/36709584/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,38038747,CCDC146 is required for sperm flagellum biogenesis and male fertility in mice.,2023,10.1007/s00018-023-05025-x,https://pubmed.ncbi.nlm.nih.gov/38038747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,37086632,Sperm DNA fragmentation and apoptosis in the sperm of men with oligozoospermia are closely related to anti-ODF2 autoantibodies.,2023,10.1016/j.prp.2023.154434,https://pubmed.ncbi.nlm.nih.gov/37086632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,40783785,METTL5 deficiency induces oligoasthenoteratozoospermia via impaired 18S rRNA m&lt;sup&gt;6&lt;/sup&gt;A methylation in humans and mice.,2025,10.1016/j.ymthe.2025.08.009,https://pubmed.ncbi.nlm.nih.gov/40783785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,41240463,TMT-based proteomic analysis reveals key proteins involved in cryoinjury of Nubian goat spermatozoa.,2025,10.1016/j.cryobiol.2025.105542,https://pubmed.ncbi.nlm.nih.gov/41240463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,36509813,FOXA1 is a transcriptional activator of Odf2/Cenexin and regulates primary ciliation.,2022,10.1038/s41598-022-25966-w,https://pubmed.ncbi.nlm.nih.gov/36509813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,37240164,Macrophage-Related Testicular Inflammation in Individuals with Idiopathic Non-Obstructive Azoospermia: A Single-Cell Analysis.,2023,10.3390/ijms24108819,https://pubmed.ncbi.nlm.nih.gov/37240164/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,40595713,Exploring the interconnected properties of cannabidiol suspensions and orodispersible films.,2025,10.1038/s41598-025-02859-2,https://pubmed.ncbi.nlm.nih.gov/40595713/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,29168316,Outer dense fibers stabilize the axoneme to maintain sperm motility.,2018,10.1111/jcmm.13457,https://pubmed.ncbi.nlm.nih.gov/29168316/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,33624366,Genome-wide ancestry and introgression in a Zambian baboon hybrid zone.,2021,10.1111/mec.15858,https://pubmed.ncbi.nlm.nih.gov/33624366/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,30889405,"Organic Zn and Cu interaction impact on sexual behaviour, semen characteristics, hormones and spermatozoal gene expression in bucks (Capra hircus).",2019,10.1016/j.theriogenology.2019.02.026,https://pubmed.ncbi.nlm.nih.gov/30889405/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,20682177,"Expression of two testis-specific genes, SPATA19 and LEMD1, in prostate cancer.",2010,10.1016/j.arcmed.2010.04.003,https://pubmed.ncbi.nlm.nih.gov/20682177/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,19886887,Elevated expression levels of testis-specific genes TEX101 and SPATA19 in basal cell carcinoma and their correlation with clinical and pathological features.,2010,10.1111/j.1365-2133.2009.09568.x,https://pubmed.ncbi.nlm.nih.gov/19886887/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,26732106,Proteomic signatures of infertile men with clinical varicocele and their validation studies reveal mitochondrial dysfunction leading to infertility.,2016,10.4103/1008-682x.170445,https://pubmed.ncbi.nlm.nih.gov/26732106/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,17332294,Standard treatments induce antigen-specific immune responses in prostate cancer.,2007,10.1158/1078-0432.ccr-06-1772,https://pubmed.ncbi.nlm.nih.gov/17332294/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,25269568,Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility.,2014,10.1093/humrep/deu235,https://pubmed.ncbi.nlm.nih.gov/25269568/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ODF2,ENSG00000136811,Unsafe,10381817,Outer dense fibre proteins from human sperm tail: molecular cloning and expression analyses of two cDNA transcripts encoding proteins of approximately 70 kDa.,1999,10.1093/molehr/5.7.627,https://pubmed.ncbi.nlm.nih.gov/10381817/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,42764673,LncRNA OIP5-AS1 Promotes Glomerular Mesangial Cell Senescence by Interacting With ELAVL1 to Upregulate HMGB1.,2026,10.1002/cbf.70311,https://pubmed.ncbi.nlm.nih.gov/42764673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,41881680,Expression and Clinical Significance of the Long Non-Coding RNA OIP5-AS1 in Alcohol Use Disorder.,2026,10.1111/adb.70146,https://pubmed.ncbi.nlm.nih.gov/41881680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,42725850,OIP5-AS1 Sponges miR-223-3p to Upregulate FoxO3 and Ameliorate Temporomandibular Joint Osteoarthritis by Inhibiting Chondrocyte Apoptosis.,2026,10.1111/jcmm.71359,https://pubmed.ncbi.nlm.nih.gov/42725850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,42599547,Potential regulation mechanism of lncRNA OIP5-AS1 influencing prognosis in acute myeloid leukemia patients via the miR-15a-5p/FOXO1 axis.,2026,10.1007/s10735-026-10936-7,https://pubmed.ncbi.nlm.nih.gov/42599547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,42196539,Serum from Antiphospholipid Syndrome Patients Downregulates Endothelial lncRNAs HIF1A-AS1 and OIP5-AS1.,2026,10.3390/ijms27104562,https://pubmed.ncbi.nlm.nih.gov/42196539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,42444536,Revealing the Correlation Between NLRP3 Inflammasome-Related Genes and Intervertebral Disc Degeneration Based Multiomic Analysis and Experimental Validation.,2026,10.1155/mi/1534745,https://pubmed.ncbi.nlm.nih.gov/42444536/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,41484292,OIP5-AS1/miR-223-3p provides potential biomarkers for chronic periodontitis and its regulatory role in inflammatory responses.,2026,10.1038/s41598-025-30569-2,https://pubmed.ncbi.nlm.nih.gov/41484292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,42491344,[Expression of Concern] Long non-coding RNA OIP5-AS1 promotes the progression of esophageal cancer by regulating miR-30a/VOPP1 expression.,2026,10.3892/ol.2026.15752,https://pubmed.ncbi.nlm.nih.gov/42491344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,42342343,LncRNA OIP5-AS1 knockdown is associated with attenuated nonylphenol-induced cardiac fibrosis.,2026,10.1265/ehpm.25-00436,https://pubmed.ncbi.nlm.nih.gov/42342343/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,40889175,Dysregulation of lncRNA OIP5-AS1 participants in the progression of diabetic retinopathy and affects the proliferation in retinal vascular endothelial cell.,2025,10.1111/jdi.70091,https://pubmed.ncbi.nlm.nih.gov/40889175/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,41378010,ING5-mediated regulation of lung cancer progression via the OIP5-AS1/miR-381-3p/SEC24A axis.,2025,10.21037/tcr-2025-1284,https://pubmed.ncbi.nlm.nih.gov/41378010/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,42565214,Retraction: Long noncoding RNA OIP5-AS1 targets Wnt-7b to affect glioma progression via modulation of miR-410.,2026,10.1042/bsr20180395_ret,https://pubmed.ncbi.nlm.nih.gov/42565214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,41586568,The OIP5 Antisense RNA 1/miR-30b-5p/RASA1 Axis Regulates Endothelial Senescence and Atherosclerosis Progression via Epigenetic Regulation.,2026,10.1002/jbt.70714,https://pubmed.ncbi.nlm.nih.gov/41586568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,40344305,LncRNA OIP5-AS1 Modulates the Biological Behaviour of Lung Cancer Cells by Regulating the hsa-miR-29b-3p/ZIC5 Axis.,2025,10.1111/jcmm.70596,https://pubmed.ncbi.nlm.nih.gov/40344305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,40384846,LncRNA OIP5-AS1 promotes immune evasion in abdominal aortic aneurysm cells by recruiting MDSCs and inhibiting CD8 + T cells through STK24 upregulation.,2025,10.1007/s10616-025-00767-x,https://pubmed.ncbi.nlm.nih.gov/40384846/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,42653658,Association Between Temozolomide Resistance and Long Non-Coding RNA Expression Profiles in Glioblastoma Cell Lines.,2026,10.3390/ph19081159,https://pubmed.ncbi.nlm.nih.gov/42653658/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,41524548,OIP5-AS1/miR-335-5p regulates osteoblast proliferation and injury in glucocorticoid-induced osteoporosis in male mice.,2026,10.1530/joe-25-0218,https://pubmed.ncbi.nlm.nih.gov/41524548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,40568293,Expression of Long Non-coding RNA in Oral Squamous Cell Carcinoma and Its Implication in Response to Radiation Therapy.,2025,10.7759/cureus.84839,https://pubmed.ncbi.nlm.nih.gov/40568293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,41151916,&lt;i&gt;OIP5-AS1&lt;/i&gt; Positively Regulates the Proliferation of Colorectal Cancer Cells by Repressing Apoptosis.,2025,10.21873/anticanres.17827,https://pubmed.ncbi.nlm.nih.gov/41151916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,41280724,IGF2BP1/HMOX1 Mediates Fate Determinations of Human Spermatogonial Stem Cells and Male Infertility via an m6A-Dependent Manner.,2025,10.34133/research.1005,https://pubmed.ncbi.nlm.nih.gov/41280724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,40599850,Design and immunogenic evaluation of multi-epitope vaccines for colorectal cancer: insights from molecular dynamics and &lt;i&gt;In-Vitro&lt;/i&gt; studies.,2025,10.3389/fonc.2025.1592072,https://pubmed.ncbi.nlm.nih.gov/40599850/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,41860703,Deciphering lncRNA and circRNA control of autophagy in osteosarcoma mechanisms and clinical translation.,2026,10.1007/s12672-026-04629-6,https://pubmed.ncbi.nlm.nih.gov/41860703/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,40529490,LncRNA OIP5-AS1 suppresses lung adenocarcinoma progression and modulates macrophage polarization through the miR-429/DOCK4 regulatory axis.,2025,10.3389/fphar.2025.1569644,https://pubmed.ncbi.nlm.nih.gov/40529490/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,40548429,Highly enriched exosomal lncRNA OIP5-AS1 regulates gastrointestinal stromal tumor (GIST) resistance to sunitinib through miR-145 and SOX9.,2025,10.1080/15384047.2025.2522543,https://pubmed.ncbi.nlm.nih.gov/40548429/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,40392837,Downregulation of OIP5-AS1 inhibits apoptosis in myocardial ischemia/reperfusion injury via modulating the MiR-145-5p/ROCK1 axis.,2025,10.1371/journal.pone.0324909,https://pubmed.ncbi.nlm.nih.gov/40392837/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,39485791,Lipid Nanoparticle-Mediated Oip5-as1 Delivery Preserves Mitochondrial Function in Myocardial Ischemia/Reperfusion Injury by Inhibiting the p53 Pathway.,2024,10.1021/acsami.4c10032,https://pubmed.ncbi.nlm.nih.gov/39485791/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,38988919,OIP5-AS1/miR-455-3p/microfibril-associated protein 2 axis exacerbates the progression of thyroid carcinoma.,2024,10.21037/tcr-24-630,https://pubmed.ncbi.nlm.nih.gov/38988919/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,41303683,Dysregulated lncRNAs in Cisplatin-Induced Nephrotoxicity and Their Association with Apoptosis and Autophagy: An Exploratory In Vitro Study.,2025,10.3390/ijms262211201,https://pubmed.ncbi.nlm.nih.gov/41303683/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,41751958,FOXM1 Signaling Network Transcriptionally Upregulates Expression of Proteins Involved in Mitotic Progression to Induce High Proliferation and Chromosomal Instability in Androgen Receptor-Low Triple-Negative Breast Cancer.,2026,10.3390/ijms27041823,https://pubmed.ncbi.nlm.nih.gov/41751958/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,35872956,LncRNA OIP5-AS1 Knockdown Facilitated the Ferroptosis and Immune Evasion by Modulating the GPX4 in Oesophageal Carcinoma.,2022,10.1155/2022/8103198,https://pubmed.ncbi.nlm.nih.gov/35872956/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,35242130,OIP5 Is a Novel Prognostic Biomarker in Clear Cell Renal Cell Cancer Correlating With Immune Infiltrates.,2022,10.3389/fimmu.2022.805552,https://pubmed.ncbi.nlm.nih.gov/35242130/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,39992487,Construction of a novel disulfidptosis and cuproptosis-related lncRNA signature for predicting the clinical outcome and immune response in stomach adenocarcinoma.,2025,10.1007/s12672-025-01969-7,https://pubmed.ncbi.nlm.nih.gov/39992487/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,37624966,Prognostic characteristics of T-cell mediated cell killing-related genes in lung adenocarcinoma.,2023,10.1080/08916934.2023.2250097,https://pubmed.ncbi.nlm.nih.gov/37624966/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OIP5,ENSG00000104147,Unsafe,39366440,"Genome-wide profiling of long non-coding RNA following ozone exposure: A randomized, controlled exposure trial.",2024,10.1016/j.envres.2024.120101,https://pubmed.ncbi.nlm.nih.gov/39366440/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,42528464,Oleoyl-acyl carrier protein hydrolase promotes respiratory syncytial virus-mediated macrophage pyroptosis by inducing mitochondrial oxidative stress.,2026,10.4196/kjpp.26.007,https://pubmed.ncbi.nlm.nih.gov/42528464/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,41727331,"Comparative Expression of &lt;i&gt;ADAMTS2&lt;/i&gt;, &lt;i&gt;CA1&lt;/i&gt;, and &lt;i&gt;OLAH&lt;/i&gt; in Immune Cells of Rheumatoid Arthritis Patients: Real-time PCR Study on &lt;i&gt;In-silico&lt;/i&gt; analysis of Treated &lt;i&gt;vs.&lt;/i&gt; Newly Diagnosed Patients.",2025,10.18502/ajmb.v17i4.20074,https://pubmed.ncbi.nlm.nih.gov/41727331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,41378480,Identification and Validation of Differentially Expressed mRNAs From Peripheral Leukocytes for Acute Stanford Type A Aortic Dissection.,2025,10.1161/jaha.125.041224,https://pubmed.ncbi.nlm.nih.gov/41378480/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,42525560,RNAemia and Severe COVID-19: Candidate Treatment Targets Identified Through Transcriptomics.,2026,10.1093/infdis/jiag390,https://pubmed.ncbi.nlm.nih.gov/42525560/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,41816098,Influenza virus infection drives upregulation of CD84 across a broad range of immune cells.,2026,10.1002/cti2.70087,https://pubmed.ncbi.nlm.nih.gov/41816098/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,41129096,"Silencing of SPI1/OLAH Axis Inhibits Pancreatic Acinar Cell Oxidative Stress, Inflammation and Apoptosis to Alleviate Hyperlipidemic Acute Pancreatitis.",2025,10.1097/mpa.0000000000002533,https://pubmed.ncbi.nlm.nih.gov/41129096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,40140612,Integrating bioinformatics and machine learning for comprehensive analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in pediatric septic shock.,2025,10.1038/s41598-025-95028-4,https://pubmed.ncbi.nlm.nih.gov/40140612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,39846195,Multi-omics analysis and experimental verification reveal testicular fatty acid metabolism disorder in non-obstructive azoospermia.,2025,10.24272/j.issn.2095-8137.2024.223,https://pubmed.ncbi.nlm.nih.gov/39846195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,41998631,"Multiomic and functional validation of ACSL3, a regulator of fatty acid metabolism, as a lymph node metastasis-associated gene in lung adenocarcinoma.",2026,10.1186/s12931-026-03671-w,https://pubmed.ncbi.nlm.nih.gov/41998631/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,41285788,High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures.,2025,10.1038/s41467-025-65262-5,https://pubmed.ncbi.nlm.nih.gov/41285788/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,36139751,"Placental OLAH Levels Are Altered in Fetal Growth Restriction, Preeclampsia and Models of Placental Dysfunction.",2022,10.3390/antiox11091677,https://pubmed.ncbi.nlm.nih.gov/36139751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,40163145,Disease-Associated Mutations of the STAT5B SH2 Domain Regulate Cytokine-Driven Enhancer Function and Mammary Development.,2025,10.1007/s10911-025-09582-8,https://pubmed.ncbi.nlm.nih.gov/40163145/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,39137778,High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases.,2024,10.1016/j.cell.2024.07.026,https://pubmed.ncbi.nlm.nih.gov/39137778/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,41333476,Comprehensive analysis of metabolism-related genes in sepsis reveals metabolic-immune heterogeneity and highlights GYG1 as a potential therapeutic target.,2025,10.3389/fimmu.2025.1682846,https://pubmed.ncbi.nlm.nih.gov/41333476/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,39628572,A transcriptome-based risk model in sepsis enables prognostic prediction and drug repositioning.,2024,10.1016/j.isci.2024.111277,https://pubmed.ncbi.nlm.nih.gov/39628572/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,40047400,Increased fatty acid production and macrophage-driven inflammation as key drivers of severe respiratory disease.,2025,10.1111/imcb.12852,https://pubmed.ncbi.nlm.nih.gov/40047400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,41732097,Transcriptome profiling of peripheral blood for inflammatory subtype classification and diagnostic model construction in asthma.,2026,10.1080/02770903.2026.2633354,https://pubmed.ncbi.nlm.nih.gov/41732097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,39237488,scConfluence: single-cell diagonal integration with regularized Inverse Optimal Transport on weakly connected features.,2024,10.1038/s41467-024-51382-x,https://pubmed.ncbi.nlm.nih.gov/39237488/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,42205448,Self-esteem and psychological immune competence of young people raised in child protection care.,2026,10.3389/fpubh.2026.1700903,https://pubmed.ncbi.nlm.nih.gov/42205448/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,42413776,Thymus-derived myeloid programs track microglial tolerance states across human cohorts.,2026,10.1016/j.neuint.2026.106221,https://pubmed.ncbi.nlm.nih.gov/42413776/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,41212055,Minimalistic transcriptomic signatures permit accurate early prediction of COVID-19 mortality.,2025,10.1172/jci.insight.195436,https://pubmed.ncbi.nlm.nih.gov/41212055/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,40352605,Advancements in biomarkers and machine learning for predicting of bronchopulmonary dysplasia and neonatal respiratory distress syndrome in preterm infants.,2025,10.3389/fped.2025.1521668,https://pubmed.ncbi.nlm.nih.gov/40352605/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,39578562,Utilizing integrated bioinformatics and machine learning approaches to elucidate biomarkers linking sepsis to fatty acid metabolism-associated genes.,2024,10.1038/s41598-024-80550-8,https://pubmed.ncbi.nlm.nih.gov/39578562/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,40440537,Is Countermovement Jump Height and One Repetition Maximum Back Squat Associated With the Peak Force of a Front Kick With and Without Carried Load?,2025,10.1519/jsc.0000000000005128,https://pubmed.ncbi.nlm.nih.gov/40440537/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,38277517,Identification of potential biomarkers in the peripheral blood of neonates with bronchopulmonary dysplasia using WGCNA and machine learning algorithms.,2024,10.1097/md.0000000000037083,https://pubmed.ncbi.nlm.nih.gov/38277517/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,38332914,The 'analysis of gene expression and biomarkers for point-of-care decision support in Sepsis' study; temporal clinical parameter analysis and validation of early diagnostic biomarker signatures for severe inflammation andsepsis-SIRS discrimination.,2023,10.3389/fimmu.2023.1308530,https://pubmed.ncbi.nlm.nih.gov/38332914/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,33692779,Machine Learning Identifies Complicated Sepsis Course and Subsequent Mortality Based on 20 Genes in Peripheral Blood Immune Cells at 24 H Post-ICU Admission.,2021,10.3389/fimmu.2021.592303,https://pubmed.ncbi.nlm.nih.gov/33692779/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,32048780,Potential biomarkers screening to predict side effects of dexamethasone in different cancers.,2020,10.1002/mgg3.1160,https://pubmed.ncbi.nlm.nih.gov/32048780/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,17082220,Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients.,2006,10.1093/dnares/dsl006,https://pubmed.ncbi.nlm.nih.gov/17082220/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OLAH,ENSG00000152463,Unsafe,6589427,"Thioesterase II, a new marker enzyme for human cells of breast epithelial origin.",1984,10.1093/jnci/73.2.323,https://pubmed.ncbi.nlm.nih.gov/6589427/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,42794930,"A Multiplex RT-QPCR Assay of ONECUT2, EZH2, and BRCA2 for the Detection of Clinically Significant Prostate Cancer in Needle Biopsies.",2026,10.3390/cancers18182962,https://pubmed.ncbi.nlm.nih.gov/42794930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,41545903,Gene-body DNA methylation of ONECUT2 predicts its expression and prostate cancer aggressiveness in needle biopsies.,2026,10.1186/s40364-026-00890-7,https://pubmed.ncbi.nlm.nih.gov/41545903/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,42230537,Low expression of ONECUT2 governs the POU6F2-beta-catenin axis to modulate cancer stemness and drives the CCL28-dependent pathway for macrophage polarization in breast cancer.,2026,10.1038/s41419-026-08909-5,https://pubmed.ncbi.nlm.nih.gov/42230537/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,41869354,Silencing of circRERE(4-5) inhibits ONECUT2-mediated tumorigenesis and metastasis in gastric cancer.,2026,10.3389/fimmu.2026.1686702,https://pubmed.ncbi.nlm.nih.gov/41869354/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,42041682,A Pan-Cancer Transcriptomic Signature for Conserved Molecular Programs Underlying Premalignant-Malignant Progression Across Common Carcinomas.,2026,10.3390/dj14040228,https://pubmed.ncbi.nlm.nih.gov/42041682/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,42479311,The role of STRA6 induced by ONECUT2 drives malignant progression and radioresistance in rectal cancer through activating the Wnt/β-Catenin signaling pathway.,2026,10.1007/s11033-026-12257-0,https://pubmed.ncbi.nlm.nih.gov/42479311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,41544857,"Onecut2, negatively regulated by methyltransferase METTL3, inhibits polycystic ovary syndrome by transcriptionally modulating SIRT3 expression.",2026,10.1016/j.bcp.2026.117712,https://pubmed.ncbi.nlm.nih.gov/41544857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,42332658,A stratified urine-based molecular diagnostic and prognostic model for non-muscle-invasive bladder cancer management.,2026,10.1186/s12885-026-16361-z,https://pubmed.ncbi.nlm.nih.gov/42332658/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,41183442,Evaluation of CIRBP and ONECUT2 for fatal hypothermia identification - a pilot study.,2025,10.1016/j.cryobiol.2025.105541,https://pubmed.ncbi.nlm.nih.gov/41183442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,41849605,Evidence for chronological diversification of spinal neuron subtypes by a shared sequence of transcription factors.,2026,10.1126/sciadv.adz3075,https://pubmed.ncbi.nlm.nih.gov/41849605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,41103012,RNA m&lt;sup&gt;1&lt;/sup&gt;A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target.,2025,10.1002/cac2.70070,https://pubmed.ncbi.nlm.nih.gov/41103012/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,41663990,Sex-related differences in gene expression in early-stage bladder cancer revealed by whole-transcriptome sequencing.,2026,10.1186/s12885-026-15666-3,https://pubmed.ncbi.nlm.nih.gov/41663990/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,42032109,Cell-specific DNA methylation in human alpha and beta cells regulates gene expression in type 2 diabetes.,2026,10.1038/s42255-026-01498-9,https://pubmed.ncbi.nlm.nih.gov/42032109/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,40461746,Spatiotemporal and single-cell atlases to dissect regional specific cell types of the developing ovary.,2025,10.1038/s42003-025-08277-4,https://pubmed.ncbi.nlm.nih.gov/40461746/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,42018572,Single-cell atlas of gastric cancer reveals malignant epithelial evolution and regulatory reprogramming of the tumor microenvironment.,2026,10.1371/journal.pone.0347679,https://pubmed.ncbi.nlm.nih.gov/42018572/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,41113031,Long intergenic non-protein coding RNA 1949 suppresses rituximab resistance in diffuse large B-cell lymphoma via H3K27me3-mediated ONECUT2 silencing.,2025,10.62347/dfev8334,https://pubmed.ncbi.nlm.nih.gov/41113031/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,38997271,Increased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via an AKT-related pathway.,2024,10.1038/s41419-024-06885-2,https://pubmed.ncbi.nlm.nih.gov/38997271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,41225269,ONECUT2-driven activation of ADAMTS14 boosts colorectal cancer stemness via Wnt pathway.,2025,10.1007/s13577-025-01319-3,https://pubmed.ncbi.nlm.nih.gov/41225269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,40500731,ONECUT2 reprograms neuroendocrine fate and is an actionable therapeutic target in small cell lung cancer.,2025,10.1186/s10020-025-01267-6,https://pubmed.ncbi.nlm.nih.gov/40500731/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,39438499,Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2.,2024,10.1038/s41531-024-00819-7,https://pubmed.ncbi.nlm.nih.gov/39438499/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,39682746,Therapeutic Exploitation of Neuroendocrine Transdifferentiation Drivers in Prostate Cancer.,2024,10.3390/cells13231999,https://pubmed.ncbi.nlm.nih.gov/39682746/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,38474011,Transcriptional Landscape of CUT-Class Homeobox Genes in Blastic Plasmacytoid Dendritic Cell Neoplasm.,2024,10.3390/ijms25052764,https://pubmed.ncbi.nlm.nih.gov/38474011/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,35582526,ONECUT2 as a key mediator of androgen receptor-independent cell growth and neuroendocrine differentiation in castration-resistant prostate cancer.,2022,10.20517/cdr.2021.108,https://pubmed.ncbi.nlm.nih.gov/35582526/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,38819630,ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity.,2025,10.1007/s13402-024-00957-3,https://pubmed.ncbi.nlm.nih.gov/38819630/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,34839358,ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY.,2021,10.1038/s41419-021-04410-3,https://pubmed.ncbi.nlm.nih.gov/34839358/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,35874785,Single-Cell Transcriptomics of Immune Cells Reveal Diversity and Exhaustion Signatures in Non-Small-Cell Lung Cancer.,2022,10.3389/fimmu.2022.854724,https://pubmed.ncbi.nlm.nih.gov/35874785/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,38504268,"Clinical effectiveness of a multitarget urine DNA test for urothelial carcinoma detection: a double-blinded, multicenter, prospective trial.",2024,10.1186/s12943-024-01974-4,https://pubmed.ncbi.nlm.nih.gov/38504268/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ONECUT2,ENSG00000119547,Unsafe,39696629,Integrating bioinformatics and machine learning to uncover lncRNA LINC00269 as a key regulator in Parkinson's disease via pyroptosis pathways.,2024,10.1186/s40001-024-02201-y,https://pubmed.ncbi.nlm.nih.gov/39696629/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOSP2,ENSG00000149507,Unsafe,40440345,Findings from transcriptomics and immunohistochemistry indicate an autoimmune disease targeting brainstem inhibitory interneurons in bovine spastic paresis.,2025,10.1371/journal.pone.0324633,https://pubmed.ncbi.nlm.nih.gov/40440345/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOSP2,ENSG00000149507,Unsafe,40709530,Subcutaneous delivery of icariin via a gelatin methacryloyl (GelMA) hydrogel sustained-release system improves ovarian function in reproductively aged mice.,2025,10.24272/j.issn.2095-8137.2024.447,https://pubmed.ncbi.nlm.nih.gov/40709530/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOSP2,ENSG00000149507,Unsafe,36042231,Single-cell transcriptome and translatome dual-omics reveals potential mechanisms of human oocyte maturation.,2022,10.1038/s41467-022-32791-2,https://pubmed.ncbi.nlm.nih.gov/36042231/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOSP2,ENSG00000149507,Unsafe,32231122,CRISPR/Cas9-Mediated Genome Editing Reveals Oosp Family Genes are Dispensable for Female Fertility in Mice.,2020,10.3390/cells9040821,https://pubmed.ncbi.nlm.nih.gov/32231122/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OOSP2,ENSG00000149507,Unsafe,34114130,Motion Responses by Occupants in Out-of-Seat Positions During Autonomous Emergency Braking.,2021,10.1007/s10439-021-02806-y,https://pubmed.ncbi.nlm.nih.gov/34114130/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,42275379,Gene therapy rescues cone function in an all-cone retina mouse model with the most common cone opsin C203R missense mutation.,2026,10.1371/journal.pone.0332684,https://pubmed.ncbi.nlm.nih.gov/42275379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,41286353,Molecular mechanisms limiting the AAV gene therapy treatment window in mouse models of blue cone monochromacy.,2025,10.1038/s42003-025-09045-0,https://pubmed.ncbi.nlm.nih.gov/41286353/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,42161901,Homozygous R383H variant in &lt;i&gt;IDUA&lt;/i&gt; gene causing pericentric retinitis pigmentosa in attenuated mucopolysaccharidosis type I.,2026,10.1080/13816810.2026.2644219,https://pubmed.ncbi.nlm.nih.gov/42161901/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,40013354,Monogenic Retinal Diseases Associated With Genes Encoding Phototransduction Proteins: A Review.,2025,10.1111/ceo.14511,https://pubmed.ncbi.nlm.nih.gov/40013354/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,38704370,Pitfalls in the genetic testing of the OPN1LW-OPN1MW gene cluster in human subjects.,2024,10.1038/s41525-024-00406-y,https://pubmed.ncbi.nlm.nih.gov/38704370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,39408969,Evaluation of Retinal Structure and Visual Function in Blue Cone Monochromacy to Develop Clinical Endpoints for L-opsin Gene Therapy.,2024,10.3390/ijms251910639,https://pubmed.ncbi.nlm.nih.gov/39408969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,41259386,Identification of pathogenic variants for the development of ultra-long axial length in myopic children.,2025,10.1371/journal.pone.0337184,https://pubmed.ncbi.nlm.nih.gov/41259386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,41153400,Inherited Retinal Diseases with High Myopia: A Review.,2025,10.3390/genes16101183,https://pubmed.ncbi.nlm.nih.gov/41153400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,40839430,Cross-species single-cell transcriptomic atlas of retinal photoreceptors reveals molecular signatures underlying color vision adaptation.,2025,10.1016/j.celrep.2025.116164,https://pubmed.ncbi.nlm.nih.gov/40839430/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,37097228,Unique Haplotypes in OPN1LW as a Common Cause of High Myopia With or Without Protanopia: A Potential Window Into Myopic Mechanism.,2023,10.1167/iovs.64.4.29,https://pubmed.ncbi.nlm.nih.gov/37097228/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,40227176,Clinical and Molecular Landscape of GLRA2 in X-Linked Early-Onset High Myopia.,2025,10.1167/iovs.66.4.30,https://pubmed.ncbi.nlm.nih.gov/40227176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,37359372,Identifying missing pieces in color vision defects: a genome-wide association study in Silk Road populations.,2023,10.3389/fgene.2023.1161696,https://pubmed.ncbi.nlm.nih.gov/37359372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,36351915,Diagnostic analysis of the highly complex OPN1LW/OPN1MW gene cluster using long-read sequencing and MLPA.,2022,10.1038/s41525-022-00334-9,https://pubmed.ncbi.nlm.nih.gov/36351915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,35759666,The landscape of submicroscopic structural variants at the &lt;i&gt;OPN1LW/OPN1MW&lt;/i&gt; gene cluster on Xq28 underlying blue cone monochromacy.,2022,10.1073/pnas.2115538119,https://pubmed.ncbi.nlm.nih.gov/35759666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,35743313,Novel OPN1LW/OPN1MW Exon 3 Haplotype-Associated Splicing Defect in Patients with X-Linked Cone Dysfunction.,2022,10.3390/ijms23126868,https://pubmed.ncbi.nlm.nih.gov/35743313/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,37001420,Blue cone monochromacy and gene therapy.,2023,10.1016/j.visres.2023.108221,https://pubmed.ncbi.nlm.nih.gov/37001420/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,37749571,Novel mutations of the X-linked genes associated with early-onset high myopia in five Chinese families.,2023,10.1186/s12920-023-01665-x,https://pubmed.ncbi.nlm.nih.gov/37749571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,35741704,Insight from OPN1LW Gene Haplotypes into the Cause and Prevention of Myopia.,2022,10.3390/genes13060942,https://pubmed.ncbi.nlm.nih.gov/35741704/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,38410159,"Expression of red/green-cone opsin mutants K82E, P187S, M273K result in unique pathobiological perturbations to cone structure and function.",2024,10.3389/fnins.2024.1368089,https://pubmed.ncbi.nlm.nih.gov/38410159/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,34343570,Characterization and allogeneic transplantation of a novel transgenic cone-rich donor mouse line.,2021,10.1016/j.exer.2021.108715,https://pubmed.ncbi.nlm.nih.gov/34343570/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,36797068,Bridging the Gap: Tailoring an Approach to Treatment in Febrile Infection-Related Epilepsy Syndrome.,2023,10.1212/wnl.0000000000207068,https://pubmed.ncbi.nlm.nih.gov/36797068/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,36692456,Color Vision in Blue Cone Monochromacy: Outcome Measures for a Clinical Trial.,2023,10.1167/tvst.12.1.25,https://pubmed.ncbi.nlm.nih.gov/36692456/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,34440353,Intermixing the &lt;i&gt;OPN1LW&lt;/i&gt; and &lt;i&gt;OPN1MW&lt;/i&gt; Genes Disrupts the Exonic Splicing Code Causing an Array of Vision Disorders.,2021,10.3390/genes12081180,https://pubmed.ncbi.nlm.nih.gov/34440353/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,39271608,Ocular genetics in the Japanese population.,2024,10.1007/s10384-024-01109-8,https://pubmed.ncbi.nlm.nih.gov/39271608/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,35163334,Regulation of Opsin Gene Expression by DNA Methylation and Histone Acetylation.,2022,10.3390/ijms23031408,https://pubmed.ncbi.nlm.nih.gov/35163334/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,36242206,Effects of color-enhancing glasses on color vision in congenital red-green color deficiencies.,2022,10.1364/oe.451295,https://pubmed.ncbi.nlm.nih.gov/36242206/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,33344057,Reading Performance in Blue Cone Monochromacy: Defining an Outcome Measure for a Clinical Trial.,2020,10.1167/tvst.9.13.13,https://pubmed.ncbi.nlm.nih.gov/33344057/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,33928237,Retinal imaging in inherited retinal diseases.,2020,10.21037/aes-20-81,https://pubmed.ncbi.nlm.nih.gov/33928237/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,30128495,Residual Cone Structure in Patients With X-Linked Cone Opsin Mutations.,2018,10.1167/iovs.18-24699,https://pubmed.ncbi.nlm.nih.gov/30128495/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,32848570,Foveal Therapy in Blue Cone Monochromacy: Predictions of Visual Potential From Artificial Intelligence.,2020,10.3389/fnins.2020.00800,https://pubmed.ncbi.nlm.nih.gov/32848570/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,35409265,"Whole Genome Sequencing, Focused Assays and Functional Studies Increasing Understanding in Cryptic Inherited Retinal Dystrophies.",2022,10.3390/ijms23073905,https://pubmed.ncbi.nlm.nih.gov/35409265/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,29386880,Human L- and M-opsins restore M-cone function in a mouse model for human blue cone monochromacy.,2018,,https://pubmed.ncbi.nlm.nih.gov/29386880/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,21705682,Characterization of a dominant cone degeneration in a green fluorescent protein-reporter mouse with disruption of Loci associated with human dominant retinal dystrophy.,2011,10.1167/iovs.11-7932,https://pubmed.ncbi.nlm.nih.gov/21705682/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN1LW,ENSG00000102076,Unsafe,2937147,"Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.",1986,10.1126/science.2937147,https://pubmed.ncbi.nlm.nih.gov/2937147/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,42883087,Bioinformatic Analysis and Tissue-Specific Expression of Clock Genes and &lt;i&gt;Opn5&lt;/i&gt; in the Chinese Giant Salamander (&lt;i&gt;Andrias davidianus&lt;/i&gt;) Under Different Light Conditions.,2026,10.3390/ani16193118,https://pubmed.ncbi.nlm.nih.gov/42883087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,42149033,Opposing Roles of OPN3 and OPN5 Affecting the Intrinsic Pupillary Light Reflex of the Mammalian Iris.,2026,10.1167/iovs.67.5.38,https://pubmed.ncbi.nlm.nih.gov/42149033/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,42639088,Hypoxia-induced OPN5 expression is associated with matrix-preserving responses in human scleral fibroblasts.,2026,10.3389/fnins.2026.1896819,https://pubmed.ncbi.nlm.nih.gov/42639088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,41507222,Neuropsin-expressing cells in the retina affect melanopsin expression and response to light in mice.,2026,10.1038/s41598-025-22815-4,https://pubmed.ncbi.nlm.nih.gov/41507222/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,41327490,The physiological functions of OPN5m.,2025,10.1186/s40662-025-00467-9,https://pubmed.ncbi.nlm.nih.gov/41327490/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,40700017,Opsin 5 mediates violet light-accelerated wound healing in mammalian corneas.,2025,10.1016/j.celrep.2025.116045,https://pubmed.ncbi.nlm.nih.gov/40700017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,41962872,Photoperiod effects on the expression of deep brain photoreceptors and gonadotrophin genes are sex- and age-dependent in Pekin ducks.,2026,10.1016/j.ygcen.2026.114928,https://pubmed.ncbi.nlm.nih.gov/41962872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,42776409,Photobiology in ophthalmology: from evolutionary adaptation to translational therapeutics.,2026,10.1007/s10384-026-01421-5,https://pubmed.ncbi.nlm.nih.gov/42776409/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,41610612,Research Note: An in vitro hypothalamic slice culture model from adult geese for investigating light-mediated regulation of avian reproduction.,2026,10.1016/j.psj.2026.106497,https://pubmed.ncbi.nlm.nih.gov/41610612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,39754930,Immunization with OPN5 increased seasonal degradation of reproductive activity in Magang ganders.,2025,10.1016/j.psj.2024.104753,https://pubmed.ncbi.nlm.nih.gov/39754930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,40878830,Development of visible light-sensitive human neuropsin (OPN5) via single amino acid substitution.,2025,10.1002/1873-3468.70130,https://pubmed.ncbi.nlm.nih.gov/40878830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,42460363,&lt;i&gt;In vivo&lt;/i&gt; characterization of blue-light-induced peripheral arterial photorelaxation using functional OCT.,2026,10.1364/boe.596182,https://pubmed.ncbi.nlm.nih.gov/42460363/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,40892281,A key spectral tuning site of UV-sensitive vertebrate non-visual opsin Opn5.,2025,10.1007/s00018-025-05879-3,https://pubmed.ncbi.nlm.nih.gov/40892281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,41561484,Demonstration of the photo-controllability of the bistable opsin OPN5 using upconversion nanoparticles with multiple emission peaks upon near-infrared photoexcitation.,2026,10.1039/d5na01109d,https://pubmed.ncbi.nlm.nih.gov/41561484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,41620773,Light and myopia: a focus on the expanding role of non-visual opsins.,2026,10.1186/s40662-025-00472-y,https://pubmed.ncbi.nlm.nih.gov/41620773/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,42612637,Prevention of myopia in a near-primate by supplemental indigo light suggests a hypothesis for the myopia boom.,2026,10.1016/j.xcrm.2026.102999,https://pubmed.ncbi.nlm.nih.gov/42612637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,40708600,BET Protein Inhibition Relieves MDSC-Mediated Immune Suppression in Chronic Lymphocytic Leukemia.,2025,10.3390/hemato6020014,https://pubmed.ncbi.nlm.nih.gov/40708600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,40436317,A repertoire of visible light-sensitive opsins in the deep-sea hydrothermal vent shrimp Rimicaris hybisae.,2025,10.1016/j.jbc.2025.110291,https://pubmed.ncbi.nlm.nih.gov/40436317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,40090886,Hypotheses in light detection by vertebrate ancient opsin in the bird brain.,2025,10.1111/jne.70020,https://pubmed.ncbi.nlm.nih.gov/40090886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,42630141,"Display color gamut as a spectral risk factor for myopia: a unifying hypothesis linking chromatic emmetropization, cone circuitry dysfunction, and the spectral deficiency of digital screens.",2026,10.3389/fopht.2026.1901460,https://pubmed.ncbi.nlm.nih.gov/42630141/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,39116655,Effect of active immunization with OPN5 on follicular development and egg production in quail under different photoperiods.,2024,10.1016/j.theriogenology.2024.08.005,https://pubmed.ncbi.nlm.nih.gov/39116655/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,38442558,Effect of immunization against OPN5 on the reproductive performance in Shan Partridge ducks under different photoperiods.,2024,10.1016/j.psj.2023.103413,https://pubmed.ncbi.nlm.nih.gov/38442558/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,41206615,Opposing expression pattern of opsin 3 and opsin 5 in the developing and adult nasal epithelium.,2025,10.1093/chemse/bjaf051,https://pubmed.ncbi.nlm.nih.gov/41206615/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,39961441,Violet light photobiomodulation therapy for depression: A double-blind randomized crossover trial.,2025,10.1016/j.jad.2025.02.031,https://pubmed.ncbi.nlm.nih.gov/39961441/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,41524434,Transcriptomic analysis of pigeon retina and pineal gland illuminated with red light.,2026,10.1080/00071668.2025.2605496,https://pubmed.ncbi.nlm.nih.gov/41524434/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,37022011,Endocrine and molecular regulation mechanisms of follicular development and egg-laying in quails under different photoperiods.,2023,10.1080/10495398.2023.2196551,https://pubmed.ncbi.nlm.nih.gov/37022011/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,35733985,OPN5 Regulating Mechanism of Follicle Development Through the TSH-DIO2/DIO3 Pathway in Mountain Ducks Under Different Photoperiods.,2022,10.3389/fphys.2022.813881,https://pubmed.ncbi.nlm.nih.gov/35733985/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,32879486,Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons.,2020,10.1038/s41586-020-2683-0,https://pubmed.ncbi.nlm.nih.gov/32879486/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,30954314,Effect and molecular regulatory mechanism of monochromatic light colors on the egg-laying performance of Yangzhou geese.,2019,10.1016/j.anireprosci.2019.03.015,https://pubmed.ncbi.nlm.nih.gov/30954314/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,26392540,Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea.,2015,10.1073/pnas.1516259112,https://pubmed.ncbi.nlm.nih.gov/26392540/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,30496813,Blue light exposure in vitro causes toxicity to trigeminal neurons and glia through increased superoxide and hydrogen peroxide generation.,2019,10.1016/j.freeradbiomed.2018.11.029,https://pubmed.ncbi.nlm.nih.gov/30496813/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,33841186,Changes in the Control of the Hypothalamic-Pituitary Gonadal Axis Across Three Differentially Selected Strains of Laying Hens (Gallus gallus domesticus).,2021,10.3389/fphys.2021.651491,https://pubmed.ncbi.nlm.nih.gov/33841186/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,30308393,Endocrine and molecular regulation mechanisms of the reproductive system of Hungarian White geese investigated under two artificial photoperiodic programs.,2019,10.1016/j.theriogenology.2018.10.001,https://pubmed.ncbi.nlm.nih.gov/30308393/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,32670092,Should I Lay or Should I Grow: Photoperiodic Versus Metabolic Cues in Chickens.,2020,10.3389/fphys.2020.00707,https://pubmed.ncbi.nlm.nih.gov/32670092/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPN5,ENSG00000124818,Unsafe,14623103,Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue.,2003,10.1016/s0014-5793(03)01212-2,https://pubmed.ncbi.nlm.nih.gov/14623103/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42688369,Morphine-induced &lt;i&gt;μ&lt;/i&gt;-opioid receptor isoform MOR-1X amplifies dependence-related signaling.,2026,10.3389/fnins.2026.1907881,https://pubmed.ncbi.nlm.nih.gov/42688369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42637754,Spatial transcriptomics reveals distinct cell type dynamics following opioid dependence in female mice with the common human μ-opioid receptor variant Oprm1 A118G.,2026,10.1038/s41467-026-75723-0,https://pubmed.ncbi.nlm.nih.gov/42637754/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42589662,The Pharmacogenomics of Opioid Response in Cancer Pain: From Receptor Polymorphisms to Tumour-Mediated Interference-A Narrative-Critical Review.,2026,10.3390/ijms27157011,https://pubmed.ncbi.nlm.nih.gov/42589662/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42525548,Acute opioid responses are modulated by dynamic interactions of &lt;i&gt;Oprm1&lt;/i&gt; and &lt;i&gt;Fgf12&lt;/i&gt;.,2026,10.7554/elife.108845,https://pubmed.ncbi.nlm.nih.gov/42525548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42249593,Mu Opioid Receptor mRNA and Protein Localization Across the Rat and Mouse Habenula.,2026,10.1002/cne.70175,https://pubmed.ncbi.nlm.nih.gov/42249593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,41596476,Hypermethylation of OPRM1: Deregulation of the Endogenous Opioid Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia.,2026,10.3390/ijms27020826,https://pubmed.ncbi.nlm.nih.gov/41596476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42543683,"The OPRM1 A118G G Allele Is Associated With Poorer Auditory-Verbal Learning and Memory, Executive Functions, and Working Memory in Veterans Undergoing Residential Treatment for Alcohol Use Disorder.",2026,10.1111/acer.70385,https://pubmed.ncbi.nlm.nih.gov/42543683/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42797389,"Associations of &lt;i&gt;OPRM1&lt;/i&gt;, &lt;i&gt;COMT&lt;/i&gt;, and &lt;i&gt;ABCB1&lt;/i&gt; Variants with Opioid Analgesic Response in Acute Renal Colic: A Candidate-Gene Study.",2026,10.3390/ph19091343,https://pubmed.ncbi.nlm.nih.gov/42797389/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42503432,μ-Opioid receptor signalling enhances Kir3 currents in glutamatergic preBötzinger complex neurons in mice.,2026,10.1113/jp291442,https://pubmed.ncbi.nlm.nih.gov/42503432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42091342,TET1 downregulation in the dorsal root ganglion and spinal cord is required for short-term sleep disturbance to delay surgical pain recovery.,2026,10.1016/j.bja.2026.02.025,https://pubmed.ncbi.nlm.nih.gov/42091342/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42468823,Pancreatic mu opioid receptors regulate metabolism and ingestive behaviors.,2026,10.1016/j.physbeh.2026.115449,https://pubmed.ncbi.nlm.nih.gov/42468823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42494179,Passive Oscillatory Body Motion Attenuates Pain-Related Behaviors and Increases β-Endorphin Immunoreactivity in a Murine Fracture Model: A Preliminary Study.,2026,10.1002/brb3.71614,https://pubmed.ncbi.nlm.nih.gov/42494179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,41904513,OPRM1/MRGPRX1 heterodimers drive opioid-induced itch through a peripheral mechanism.,2026,10.1186/s12929-026-01238-x,https://pubmed.ncbi.nlm.nih.gov/41904513/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,41617672,Effects of chronic ethanol consumption on brain GLP-1R gene expression in mice and humans.,2026,10.1038/s41398-026-03838-5,https://pubmed.ncbi.nlm.nih.gov/41617672/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42385698,Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.,2026,10.1016/j.neuron.2026.06.002,https://pubmed.ncbi.nlm.nih.gov/42385698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42588153,Genetic Variants Influencing Taste Perception and Food Preferences: Current Evidence.,2026,10.3390/nu18152531,https://pubmed.ncbi.nlm.nih.gov/42588153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42157272,NRSF regulation of OPRM1 through histone acetylation.,2026,10.1186/s13148-026-02146-5,https://pubmed.ncbi.nlm.nih.gov/42157272/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,40780965,"Neuronal Colocalization of μ-Opioid Receptor, κ-Opioid Receptor, and Oxytocin Receptor mRNA in the Central Nucleus of the Amygdala in Male and Female Mice.",2025,10.1523/eneuro.0059-25.2025,https://pubmed.ncbi.nlm.nih.gov/40780965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,41795244,"Differential impacts of exon 1-associated and exon 11-associated variants of the rat mu opioid receptor gene, Oprm1, on buprenorphine- and morphine-induced analgesia and respiratory depression in male rats.",2026,10.1016/j.molpha.2026.100112,https://pubmed.ncbi.nlm.nih.gov/41795244/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42355425,Pathways and Genetic Determinants of Impulse Control Disorders in Parkinson's Disease.,2026,10.3390/life16060897,https://pubmed.ncbi.nlm.nih.gov/42355425/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42492880,Role of genetic polymorphisms on opioid safety and efficacy in cancer pain: A systematic review and meta-analysis.,2026,10.1016/j.ejphar.2026.179173,https://pubmed.ncbi.nlm.nih.gov/42492880/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,41597459,Pharmacogenomics and Opioid Efficacy in Sickle Cell Disease.,2026,10.3390/medicina62010172,https://pubmed.ncbi.nlm.nih.gov/41597459/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,40873551,A case-control study on the individualized use of opioid analgesics based on single-nucleotide polymorphism.,2025,10.3389/fphar.2025.1629866,https://pubmed.ncbi.nlm.nih.gov/40873551/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,39551606,Morphine treatment restricts response to immunotherapy in oral squamous cell carcinoma.,2024,10.1136/jitc-2024-009962,https://pubmed.ncbi.nlm.nih.gov/39551606/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,41717434,In silico evaluation of natural opioid ligands interaction and their therapeutic prospects in neuroinflammation.,2026,10.1007/s40203-026-00584-w,https://pubmed.ncbi.nlm.nih.gov/41717434/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42237480,Sex Difference in Effect of the OPRM1 Gene A118G (rs1799971) Single-Nucleotide Polymorphism on the Requirement for Postoperative Fentanyl in Japanese Patients Who Underwent Laparoscopic-Assisted Colectomy.,2026,10.1002/npr2.70140,https://pubmed.ncbi.nlm.nih.gov/42237480/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42679072,Unraveling the Mystery of Pain: A Unique Clinical Encounter and Case Report.,2026,,https://pubmed.ncbi.nlm.nih.gov/42679072/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,41462800,"Personalized Perioperative Opioid Strategies in Children: Focus on Methadone, Pharmacogenomics and Prevention of Persistent Postoperative Opioid Use.",2025,10.3390/children12121660,https://pubmed.ncbi.nlm.nih.gov/41462800/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,41477432,OPRM1 A118G Polymorphism and Ondansetron Efficacy for Postoperative Nausea and Vomiting in Laparoscopic Gynaecological Surgery: A Retrospective Cohort Study.,2025,10.2147/tcrm.s551616,https://pubmed.ncbi.nlm.nih.gov/41477432/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,41200574,Association of &lt;i&gt;CYP2B6&lt;/i&gt; and &lt;i&gt;OPRM1&lt;/i&gt; Genotypes with Methadone Dose Requirements and Serum Concentrations in a Vietnamese Cohorts.,2025,10.2478/bjmg-2025-0010,https://pubmed.ncbi.nlm.nih.gov/41200574/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,41751199,The Role of Biomarkers in Personalized Anesthesia: From Physiological Parameters to Molecular Diagnostics.,2026,10.3390/biomedicines14020300,https://pubmed.ncbi.nlm.nih.gov/41751199/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,42824314,Population prevalence of high-risk pharmacogenetic configurations in a healthy older Australian reference cohort.,2026,10.3389/fphar.2026.1881869,https://pubmed.ncbi.nlm.nih.gov/42824314/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,40006034,Association of OPRM1 and OPRD1 Polymorphisms with Pain and Opioid Adverse Reactions in Colorectal Cancer.,2025,10.3390/ph18020220,https://pubmed.ncbi.nlm.nih.gov/40006034/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OPRM1,ENSG00000112038,Unsafe,16580639,The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor.,2006,10.1016/j.bbrc.2006.03.084,https://pubmed.ncbi.nlm.nih.gov/16580639/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1D2,ENSG00000184166,Unsafe,42807750,Extra-nasal odorant receptors: molecular mechanisms and therapeutic implications.,2026,10.3389/fphys.2026.1869917,https://pubmed.ncbi.nlm.nih.gov/42807750/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1D2,ENSG00000184166,Unsafe,41605008,"Unlocking the anatomical code of flavor and lipids in grass carp (Ctenopharyngodon idellus) fish oil from different tissue parts by SPME-GC-MS, molecular docking, and lipidomics.",2026,10.1016/j.foodchem.2026.148088,https://pubmed.ncbi.nlm.nih.gov/41605008/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1D2,ENSG00000184166,Unsafe,42702187,Tracking the volatile fingerprint of crayfish by-product shrimp sauce during a rapid fermentation: A synergistic strategy using flavoromics and molecular docking.,2026,10.1016/j.foodchem.2026.151053,https://pubmed.ncbi.nlm.nih.gov/42702187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1D2,ENSG00000184166,Unsafe,41894497,Structural basis of odorant recognition by a mammalian class II odorant receptor.,2026,10.1126/sciadv.aeb9026,https://pubmed.ncbi.nlm.nih.gov/41894497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1D2,ENSG00000184166,Unsafe,41750927,"Spreading Degree Modulates Floral Aroma Development in Green Tea: Integrated GC-E-Nose, Metabolomics, and Molecular Docking Reveals Key Odorants and Olfactory Receptor Interactions.",2026,10.3390/foods15040735,https://pubmed.ncbi.nlm.nih.gov/41750927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1D2,ENSG00000184166,Unsafe,41303652,Development and Optimization of an RNA-Isolating Protocol for Mammalian Spermatozoa.,2025,10.3390/ijms262211171,https://pubmed.ncbi.nlm.nih.gov/41303652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1D2,ENSG00000184166,Unsafe,41154105,Compounds of Essential Oils from Different Parts of &lt;i&gt;Cinnamomum cassia&lt;/i&gt; and the Perception Mechanism of Their Characteristic Flavors.,2025,10.3390/foods14203570,https://pubmed.ncbi.nlm.nih.gov/41154105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1D2,ENSG00000184166,Unsafe,34947816,Comparing Native Crystal Structures and AlphaFold2 Predicted Water-Soluble G Protein-Coupled Receptor QTY Variants.,2021,10.3390/life11121285,https://pubmed.ncbi.nlm.nih.gov/34947816/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1D2,ENSG00000184166,Unsafe,27540365,Olfactory Receptors Modulate Physiological Processes in Human Airway Smooth Muscle Cells.,2016,10.3389/fphys.2016.00339,https://pubmed.ncbi.nlm.nih.gov/27540365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1D2,ENSG00000184166,Unsafe,23525651,Human olfactory sensitivity for bourgeonal and male infertility: a preliminary investigation.,2013,10.1007/s00405-013-2441-0,https://pubmed.ncbi.nlm.nih.gov/23525651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1D2,ENSG00000184166,Unsafe,25665864,Olfactory threshold for bourgeonal and sexual desire in young adult males.,2015,10.1016/j.mehy.2015.01.035,https://pubmed.ncbi.nlm.nih.gov/25665864/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1D2,ENSG00000184166,Unsafe,31046287,In Silico Peptide Repertoire of Human Olfactory Receptor Proteomes on High-Stringency Mass Spectrometry.,2019,10.1021/acs.jproteome.8b00494,https://pubmed.ncbi.nlm.nih.gov/31046287/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1D2,ENSG00000184166,Unsafe,23508273,Novel bourgeonal fragrance conjugates for the detection of prostate cancer.,2013,10.1007/s10637-013-9943-x,https://pubmed.ncbi.nlm.nih.gov/23508273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1D2,ENSG00000184166,Unsafe,18618409,Odorant-receptor interactions and odor percept: a chemical perspective.,2008,10.1002/cbdv.200890101,https://pubmed.ncbi.nlm.nih.gov/18618409/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1D2,ENSG00000184166,Unsafe,20378596,Human male superiority in olfactory sensitivity to the sperm attractant odorant bourgeonal.,2010,10.1093/chemse/bjq030,https://pubmed.ncbi.nlm.nih.gov/20378596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1D2,ENSG00000184166,Unsafe,16820410,Novel function of beta-arrestin2 in the nucleus of mature spermatozoa.,2006,10.1242/jcs.03046,https://pubmed.ncbi.nlm.nih.gov/16820410/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1D2,ENSG00000184166,Unsafe,15458659,Dual capacity of a human olfactory receptor.,2004,10.1016/j.cub.2004.09.034,https://pubmed.ncbi.nlm.nih.gov/15458659/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR1D2,ENSG00000184166,Unsafe,12663925,Identification of a testicular odorant receptor mediating human sperm chemotaxis.,2003,10.1126/science.1080376,https://pubmed.ncbi.nlm.nih.gov/12663925/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2A4,ENSG00000180658,Unsafe,41664424,"Treatment With Cyclohexyl Salicylate, an OR2A4/7 Agonist, Promotes Hair Growth and the Expansion of Epithelial Progenitor Cells in Human Hair Follicles Ex Vivo.",2026,10.1111/exd.70217,https://pubmed.ncbi.nlm.nih.gov/41664424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2A4,ENSG00000180658,Unsafe,37386024,Applying cosmetic oil with added aromatic compounds improves tactile sensitivity and skin properties.,2023,10.1038/s41598-023-37361-0,https://pubmed.ncbi.nlm.nih.gov/37386024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2A4,ENSG00000180658,Unsafe,30091289,Functional characterization of the extranasal OR2A4/7 expressed in human melanocytes.,2018,10.1111/exd.13764,https://pubmed.ncbi.nlm.nih.gov/30091289/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2A4,ENSG00000180658,Unsafe,27315375,Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation.,2017,10.1111/exd.13132,https://pubmed.ncbi.nlm.nih.gov/27315375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2A4,ENSG00000180658,Unsafe,33448546,Mechanisms underlying the promotion of 5-hydroxytryptamine secretion in enterochromaffin cells of constipation mice by Bifidobacterium and Lactobacillus.,2021,10.1111/nmo.14082,https://pubmed.ncbi.nlm.nih.gov/33448546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2A4,ENSG00000180658,Unsafe,30906443,Searching for perturbed biological pathways and genes through analyzing the expression profile changes in osteoclasts after treatment by bisphosphonates.,2019,10.3892/etm.2019.7219,https://pubmed.ncbi.nlm.nih.gov/30906443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2A4,ENSG00000180658,Unsafe,26318001,"Comparative Genomic, MicroRNA, and Tissue Analyses Reveal Subtle Differences between Non-Diabetic and Diabetic Foot Skin.",2015,10.1371/journal.pone.0137133,https://pubmed.ncbi.nlm.nih.gov/26318001/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR2A4,ENSG00000180658,Unsafe,22888021,G protein-coupled receptors participate in cytokinesis.,2012,10.1002/cm.21055,https://pubmed.ncbi.nlm.nih.gov/22888021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR6C2,ENSG00000179695,Unsafe,39633301,Genomic signatures of sensory adaptation and evolution in pangolins.,2024,10.1186/s12864-024-11063-x,https://pubmed.ncbi.nlm.nih.gov/39633301/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR9A2,ENSG00000179468,Unsafe,38235001,CCL7 and olfactory transduction pathway activation play an important role in the formation of CaOx and CaP kidney stones.,2023,10.3389/fgene.2023.1267545,https://pubmed.ncbi.nlm.nih.gov/38235001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OR9A2,ENSG00000179468,Unsafe,32640699,Novel Nasal Epithelial Cell Markers of Parkinson's Disease Identified Using Cells Treated with α-Synuclein Preformed Fibrils.,2020,10.3390/jcm9072128,https://pubmed.ncbi.nlm.nih.gov/32640699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,42788364,Mechanism of ORC1 Regulating Cancer Stemness and Cisplatin Resistance in Non-Small Cell Lung Cancer.,2026,10.1002/jbt.71078,https://pubmed.ncbi.nlm.nih.gov/42788364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,41469700,SLC25A mitochondrial carriers as biomarkers and therapeutic targets of spaceflight-induced dysfunction: the ADP/ATP carrier (AAC3) as a structural case study.,2025,10.1186/s12967-025-07505-z,https://pubmed.ncbi.nlm.nih.gov/41469700/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,42575441,ATR-dependent phosphorylation of the histone acetyltransferase HBO1 suppresses chromatin binding and promotes replication stress responses.,2026,10.1016/j.jbc.2026.113419,https://pubmed.ncbi.nlm.nih.gov/42575441/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,41356527,Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma.,2025,10.3748/wjg.v31.i44.112481,https://pubmed.ncbi.nlm.nih.gov/41356527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,40948373,IGF2BP1/ORC1 Axis Influences Nonsmall Cell Lung Cancer Progression via m6A Methylation Modification.,2025,10.1096/fj.202501075rr,https://pubmed.ncbi.nlm.nih.gov/40948373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,40973452,"Control of the archaeal DNA damage-responsive pathway by phosphorylation of Orc1-2, the global regulator in Saccharolobus islandicus.",2025,10.1093/nar/gkaf927,https://pubmed.ncbi.nlm.nih.gov/40973452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,41667842,"Integration of ploidy, Orc1/Cdc6 homolog function, and lysine acetylation with phosphate limitation and UV stress responses of Haloferax volcanii.",2026,10.1007/s00792-026-01420-x,https://pubmed.ncbi.nlm.nih.gov/41667842/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,40304571,DNA replication in primary hepatocytes without the six-subunit ORC.,2025,10.7554/elife.102915,https://pubmed.ncbi.nlm.nih.gov/40304571/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,42100701,An Orc1 initiator-specific motif (ISM)-related region limits ORC-ssDNA binding and promotes replication origin specificity in budding yeast.,2026,10.3389/fmicb.2026.1778270,https://pubmed.ncbi.nlm.nih.gov/42100701/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,41379386,Origin recognition complex subunit 1 functions as an oncogenic driver and therapeutic target in cancer.,2025,10.1007/s12672-025-04257-6,https://pubmed.ncbi.nlm.nih.gov/41379386/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,40617800,FGF13 prevents age-related hearing loss by protecting spiral ganglion neurons and ribbon synapses from injury.,2025,10.1038/s41420-025-02607-5,https://pubmed.ncbi.nlm.nih.gov/40617800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,41942958,Identification and verification of an eight-gene prognostic signature for colorectal cancer based on tumor-associated macrophages.,2026,10.1186/s12885-026-15965-9,https://pubmed.ncbi.nlm.nih.gov/41942958/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,41258386,High ORC6 expression is a prognostic indicator of poor survival in glioma patients.,2025,10.1038/s41598-025-24630-3,https://pubmed.ncbi.nlm.nih.gov/41258386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,37833711,Origin recognition complex subunit 1(ORC1) is a potential biomarker and therapeutic target in cancer.,2023,10.1186/s12920-023-01691-9,https://pubmed.ncbi.nlm.nih.gov/37833711/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,42203769,RNAs anchoring replication complex control initiation and firing of DNA replication.,2026,10.1038/s41467-026-73478-2,https://pubmed.ncbi.nlm.nih.gov/42203769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,40808344,MicroRNA‑885‑5p regulates cell cycle progression in liver cancer cells.,2025,10.3892/ijmm.2025.5608,https://pubmed.ncbi.nlm.nih.gov/40808344/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,37945594,The integrative multi-omics approach identifies the novel competing endogenous RNA (ceRNA) network in colorectal cancer.,2023,10.1038/s41598-023-46620-z,https://pubmed.ncbi.nlm.nih.gov/37945594/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,38756571,Up-regulated ORC1 promotes lung adenocarcinoma by inhibiting ferroptosis via SLC7A11 dependent pathway.,2024,10.1016/j.heliyon.2024.e30506,https://pubmed.ncbi.nlm.nih.gov/38756571/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,39082875,ORC1 enhances repressive epigenetic modifications on HIV-1 LTR to promote HIV-1 latency.,2024,10.1128/jvi.00035-24,https://pubmed.ncbi.nlm.nih.gov/39082875/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,41064634,Integrated analysis and experimental validation of E2F2 as a potential prognostic biomarker and its oncogenic roles in serous ovarian cancer.,2025,10.3389/fmolb.2025.1661558,https://pubmed.ncbi.nlm.nih.gov/41064634/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,40697926,Constructing a novel mitochondrial metabolism-related genes signature to evaluate tumor immune microenvironment and predict survival of colorectal cancer.,2025,10.3389/fmed.2025.1618471,https://pubmed.ncbi.nlm.nih.gov/40697926/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,38880869,Integration of mult-omics and nucleotide metabolism reprogramming signature analysis reveals gastric cancer immunological and prognostic features.,2024,10.1186/s12935-024-03396-0,https://pubmed.ncbi.nlm.nih.gov/38880869/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,40276654,Assessing the prognostic and therapeutic value of cuproptosis-related genes in colon adenocarcinoma patients.,2025,10.3389/fcell.2025.1550982,https://pubmed.ncbi.nlm.nih.gov/40276654/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,39179892,Combination of AID2 and BromoTag expands the utility of degron-based protein knockdowns.,2024,10.1038/s44319-024-00224-4,https://pubmed.ncbi.nlm.nih.gov/39179892/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,40497153,HIV-1 latency: From acquaintance to confidant.,2025,10.1016/j.jve.2025.100597,https://pubmed.ncbi.nlm.nih.gov/40497153/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,38926605,"Stemness subtypes in lower-grade glioma with prognostic biomarkers, tumor microenvironment, and treatment response.",2024,10.1038/s41598-024-65717-7,https://pubmed.ncbi.nlm.nih.gov/38926605/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,37948380,Stemness genes and miR-1247-3p expression associate with clinicopathological parameters and prognosis in lung adenocarcinoma.,2023,10.1371/journal.pone.0294171,https://pubmed.ncbi.nlm.nih.gov/37948380/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,38617504,Identification and validation of the clinical prediction model and biomarkers based on chromatin regulators in colon cancer by integrated analysis of bulk- and single-cell RNA sequencing data.,2024,10.21037/tcr-23-1886,https://pubmed.ncbi.nlm.nih.gov/38617504/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC1,ENSG00000085840,Unsafe,36498936,"Dissection of Functional Domains of Orc1-2, the Archaeal Global DNA Damage-Responsive Regulator.",2022,10.3390/ijms232314609,https://pubmed.ncbi.nlm.nih.gov/36498936/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,41063164,A novel disulfidptosis-related mRNA signature predicts prognosis and therapeutic response in lung squamous cell carcinoma.,2025,10.1186/s12890-025-03920-6,https://pubmed.ncbi.nlm.nih.gov/41063164/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,41758868,Aneuploidy alleviates the cell proliferation defect caused by mutations affecting origin licensing in Saccharomyces cerevisiae.,2026,10.1371/journal.pgen.1012063,https://pubmed.ncbi.nlm.nih.gov/41758868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,40304571,DNA replication in primary hepatocytes without the six-subunit ORC.,2025,10.7554/elife.102915,https://pubmed.ncbi.nlm.nih.gov/40304571/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,40184174,DNA bending mediated by ORC is essential for replication licensing in budding yeast.,2025,10.1073/pnas.2502277122,https://pubmed.ncbi.nlm.nih.gov/40184174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,40658797,A Trade-Off between Body Mass and Cancer Resistance in Cetaceans Is Mediated by Cell Cycle-Related Gene Evolution.,2025,10.1093/molbev/msaf159,https://pubmed.ncbi.nlm.nih.gov/40658797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,40530691,Specific origin selection and excess functional MCM2-7 loading in ORC-deficient cells.,2025,10.1093/nar/gkaf518,https://pubmed.ncbi.nlm.nih.gov/40530691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,41136745,Interactive effects of genotype with prenatal stress on DNA methylation at birth.,2025,10.1038/s41380-025-03312-6,https://pubmed.ncbi.nlm.nih.gov/41136745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,34934348,Expression and Clinical Significance of Origin Recognition Complex Subunit 6 in Breast Cancer - A Comprehensive Bioinformatics Analysis.,2021,10.2147/ijgm.s342597,https://pubmed.ncbi.nlm.nih.gov/34934348/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,38498682,The Absence of Intra-Tumoral Tertiary Lymphoid Structures is Associated with a Worse Prognosis and mTOR Signaling Activation in Hepatocellular Carcinoma with Liver Transplantation: A Multicenter Retrospective Study.,2024,10.1002/advs.202309348,https://pubmed.ncbi.nlm.nih.gov/38498682/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,32989049,A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins.,2020,10.1074/jbc.ra120.015450,https://pubmed.ncbi.nlm.nih.gov/32989049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,36205357,Systemic analysis of the DNA replication regulator origin recognition complex in lung adenocarcinomas identifies prognostic and expression significance.,2023,10.1002/cam4.5238,https://pubmed.ncbi.nlm.nih.gov/36205357/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,33732365,"PSMC2, ORC5 and KRTDAP are specific biomarkers for HPV-negative head and neck squamous cell carcinoma.",2021,10.3892/ol.2021.12550,https://pubmed.ncbi.nlm.nih.gov/33732365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,32194798,"Novel candidate biomarkers of origin recognition complex 1, 5 and 6 for survival surveillance in patients with hepatocellular carcinoma.",2020,10.7150/jca.39163,https://pubmed.ncbi.nlm.nih.gov/32194798/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,32907849,Juvenile hormone acts through FoxO to promote Cdc2 and Orc5 transcription for polyploidy-dependent vitellogenesis.,2020,10.1242/dev.188813,https://pubmed.ncbi.nlm.nih.gov/32907849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,32830194,Expression Profile and Prognostic Values of Mini-Chromosome Maintenance Families (MCMs) in Breast Cancer.,2020,10.12659/msm.923673,https://pubmed.ncbi.nlm.nih.gov/32830194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,33498209,Reticular Basement Membrane Thickness Is Associated with Growth- and Fibrosis-Promoting Airway Transcriptome Profile-Study in Asthma Patients.,2021,10.3390/ijms22030998,https://pubmed.ncbi.nlm.nih.gov/33498209/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,34196372,GWAS in Africans identifies novel lipids loci and demonstrates heterogenous association within Africa.,2021,10.1093/hmg/ddab174,https://pubmed.ncbi.nlm.nih.gov/34196372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,32507983,Genotoxic effects and proteomic analysis on Allium cepa var. agrogarum L. root cells under Pb stress.,2020,10.1007/s10646-020-02236-x,https://pubmed.ncbi.nlm.nih.gov/32507983/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,32808929,The dynamic nature of the human origin recognition complex revealed through five cryoEM structures.,2020,10.7554/elife.58622,https://pubmed.ncbi.nlm.nih.gov/32808929/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,33741931,Stabilisation of half MCM ring by Cdt1 during DNA insertion.,2021,10.1038/s41467-021-21932-8,https://pubmed.ncbi.nlm.nih.gov/33741931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,19956593,The SNF2-family member Fun30 promotes gene silencing in heterochromatic loci.,2009,10.1371/journal.pone.0008111,https://pubmed.ncbi.nlm.nih.gov/19956593/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,15558079,Analysis of the RELN gene as a genetic risk factor for autism.,2005,10.1038/sj.mp.4001614,https://pubmed.ncbi.nlm.nih.gov/15558079/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,7579692,"The origin recognition complex in silencing, cell cycle progression, and DNA replication.",1995,10.1091/mbc.6.6.741,https://pubmed.ncbi.nlm.nih.gov/7579692/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,12808023,Drosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensation.,2003,10.1091/mbc.e02-11-0706,https://pubmed.ncbi.nlm.nih.gov/12808023/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC5,ENSG00000164815,Unsafe,9765232,"ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases.",1998,10.1074/jbc.273.42.27137,https://pubmed.ncbi.nlm.nih.gov/9765232/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,42039914,Novel Insights into the Oncogenic Role and Clinical Significance of ORC6L in Breast Cancer.,2026,10.2147/bctt.s586715,https://pubmed.ncbi.nlm.nih.gov/42039914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,42553170,ORC6 marks a replication-active malignant epithelial state and is associated with immune-low features in oral squamous cell carcinoma.,2026,10.3389/fonc.2026.1882429,https://pubmed.ncbi.nlm.nih.gov/42553170/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,42294349,&lt;i&gt;ORC6&lt;/i&gt; drives the malignant progression of cervical squamous intraepithelial lesions and serves as a biomarker for high-grade dysplasia.,2026,10.3389/fonc.2026.1795793,https://pubmed.ncbi.nlm.nih.gov/42294349/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,42247779,TRPS1 inhibits cervical cancer progression by suppressing ORC6-mediated tumor stemness.,2026,10.1016/j.tice.2026.103655,https://pubmed.ncbi.nlm.nih.gov/42247779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,41875810,"Machine learning derived ORC6 as a hub biomarker for predicting tumor microenvironment, prognoses, and therapeutic responses in lung adenocarcinoma.",2026,10.1016/j.tranon.2026.102739,https://pubmed.ncbi.nlm.nih.gov/41875810/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,41992535,ORC6 Exerts Oncogenic Functions in Kidney Renal Clear Cell Carcinoma by Regulating Cell Proliferation and Apoptosis: A Prognostic and Immunological Indicator for Future Clinical Interventions.,2026,10.1002/cbin.70159,https://pubmed.ncbi.nlm.nih.gov/41992535/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,42363755,DNA-damage dependent interaction of Orc6 to SMARCA1 in S-phase modulates chromatin remodeling.,2026,10.1093/nar/gkag582,https://pubmed.ncbi.nlm.nih.gov/42363755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,41258386,High ORC6 expression is a prognostic indicator of poor survival in glioma patients.,2025,10.1038/s41598-025-24630-3,https://pubmed.ncbi.nlm.nih.gov/41258386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,40986665,Unexpected molecular mechanism of Orc6-based Meier-Gorlin syndrome: insights from a humanized Drosophila model.,2025,10.1093/genetics/iyaf203,https://pubmed.ncbi.nlm.nih.gov/40986665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,41523832,Curcumol overcomes cisplatin resistance and rewires glycolysis-H3K9la-ORC6 axis to trigger ferroptosis in bladder cancer.,2025,10.21147/j.issn.1000-9604.2025.06.13,https://pubmed.ncbi.nlm.nih.gov/41523832/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,38971772,Origin recognition complex 6 overexpression promotes growth of glioma cells.,2024,10.1038/s41419-024-06764-w,https://pubmed.ncbi.nlm.nih.gov/38971772/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,39349930,Elevated origin recognition complex subunit 6 expression promotes non-small cell lung cancer cell growth.,2024,10.1038/s41419-024-07081-y,https://pubmed.ncbi.nlm.nih.gov/39349930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,40185346,METTL3/IGF2BP3 mediates ORC6 via N6-methyladenosine modification to promote the progression of pancreatic ductal adenocarcinoma.,2025,10.1016/j.gene.2025.149468,https://pubmed.ncbi.nlm.nih.gov/40185346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,39143485,Origin recognition complex subunit 6 (ORC6) is a key mediator of LPS-induced NFκB activation and the pro-inflammatory response.,2024,10.1186/s12964-024-01768-7,https://pubmed.ncbi.nlm.nih.gov/39143485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,37788012,scRNA-seq reveals that origin recognition complex subunit 6 regulates mouse spermatogonial cell proliferation and apoptosis via activation of Wnt/β-catenin signaling.,2024,10.4103/aja202330,https://pubmed.ncbi.nlm.nih.gov/37788012/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,37901236,Multi-omics analysis reveals the involvement of origin recognition complex subunit 6 in tumor immune regulation and malignant progression.,2023,10.3389/fimmu.2023.1236806,https://pubmed.ncbi.nlm.nih.gov/37901236/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,36978046,"ORC6, a novel prognostic biomarker, correlates with T regulatory cell infiltration in prostate adenocarcinoma: a pan-cancer analysis.",2023,10.1186/s12885-023-10763-z,https://pubmed.ncbi.nlm.nih.gov/36978046/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,41055997,An Orc6 tether mediates ORC binding-site switching during replication origin licensing.,2025,10.1073/pnas.2510685122,https://pubmed.ncbi.nlm.nih.gov/41055997/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,38288041,ORC6 acts as an effective prognostic predictor for non‑small cell lung cancer and is closely associated with tumor progression.,2024,10.3892/ol.2024.14229,https://pubmed.ncbi.nlm.nih.gov/38288041/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,41310087,AlphaFold-guided phylogenetic analyses suggest surprising heterogeneity in metazoan replication origin licensing mechanisms.,2026,10.1038/s44318-025-00628-5,https://pubmed.ncbi.nlm.nih.gov/41310087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,40255404,Clinical potential and experimental validation of prognostic genes in hepatocellular carcinoma revealed by risk modeling utilizing single cell and transcriptome constructs.,2025,10.3389/fimmu.2025.1541252,https://pubmed.ncbi.nlm.nih.gov/40255404/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,40792136,Integrative single-cell and bulk transcriptomic analyses identify a robust four-gene signature for risk stratification in neuroblastoma.,2025,10.21037/tcr-2025-569,https://pubmed.ncbi.nlm.nih.gov/40792136/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,40940326,Temporal control of human DNA replication licensing by CDK4/6-RB signalling and chemical genetics.,2025,10.1038/s41467-025-63669-8,https://pubmed.ncbi.nlm.nih.gov/40940326/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,34934348,Expression and Clinical Significance of Origin Recognition Complex Subunit 6 in Breast Cancer - A Comprehensive Bioinformatics Analysis.,2021,10.2147/ijgm.s342597,https://pubmed.ncbi.nlm.nih.gov/34934348/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,36205357,Systemic analysis of the DNA replication regulator origin recognition complex in lung adenocarcinomas identifies prognostic and expression significance.,2023,10.1002/cam4.5238,https://pubmed.ncbi.nlm.nih.gov/36205357/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,35956952,Transcriptome Analysis of the Anti-Proliferative Effects of Ginsenoside Rh3 on HCT116 Colorectal Cancer Cells.,2022,10.3390/molecules27155002,https://pubmed.ncbi.nlm.nih.gov/35956952/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,33859719,Comprehensive Analysis of the Control of Cancer Stem Cell Characteristics in Endometrial Cancer by Network Analysis.,2021,10.1155/2021/6653295,https://pubmed.ncbi.nlm.nih.gov/33859719/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,35117216,Comprehensive analysis of transcriptome data stemness indices identifies key genes for controlling cancer stem cell characteristics in gastric cancer.,2020,10.21037/tcr-20-704,https://pubmed.ncbi.nlm.nih.gov/35117216/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ORC6,ENSG00000091651,Unsafe,17267692,Roles of the CDK phosphorylation sites of yeast Cdc6 in chromatin binding and rereplication.,2007,10.1091/mbc.e06-06-0544,https://pubmed.ncbi.nlm.nih.gov/17267692/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,42527583,PALM3 and hearing loss: a potential dual diagnosis interfering with novel gene discovery.,2026,10.1038/s41431-026-02206-7,https://pubmed.ncbi.nlm.nih.gov/42527583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,41599512,"Evaluation of the Biodegradability Potential of Antibacterial Poly(lactic acid)/Glycero-(9,10-trioxolane)-trialeate Films in Soil.",2026,10.3390/polym18020216,https://pubmed.ncbi.nlm.nih.gov/41599512/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,41291450,Transcriptomic and metabolomic basis of seasonal auditory sensitivity variations in the red-eared slider (Trachemys scripta elegans).,2025,10.1186/s12864-025-12358-3,https://pubmed.ncbi.nlm.nih.gov/41291450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,39943967,&lt;i&gt;In vivo&lt;/i&gt; consequences of varying degrees of &lt;i&gt;OTOA&lt;/i&gt; alteration elucidated using knock-in mouse models and pseudogene contamination-free long-read sequencing.,2025,10.1016/j.gendis.2025.101533,https://pubmed.ncbi.nlm.nih.gov/39943967/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,39771406,"Characterization and Evaluation of Zero-Order Release System Comprising Glycero-(9,10-trioxolane)-trialeate and PLA: Opportunity for Packaging and Biomedicine Applications.",2024,10.3390/polym16243554,https://pubmed.ncbi.nlm.nih.gov/39771406/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,41070225,"Intrauterine phenotype, genetic analysis, and pregnancy follow-up of fetuses with the 16p12.2 microdeletion.",2025,10.3389/fgene.2025.1595399,https://pubmed.ncbi.nlm.nih.gov/41070225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,39769235,Unveiling Secondary Mutations in Blended Phenotypes: Dual ERCC4 and OTOA Pathogenic Variants Through WES Analysis.,2024,10.3390/ijms252413471,https://pubmed.ncbi.nlm.nih.gov/39769235/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,42872487,Genomic Insights into Cold Adaptation and Demographic History of Amur-Heilong River Basin Populations.,2026,10.1093/gpbjnl/qzag106,https://pubmed.ncbi.nlm.nih.gov/42872487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,40900730,Genetic predisposition to immune dysregulation and extracellular matrix remodeling in cardiac arrhythmia reveals potential mediation by &lt;i&gt;SPP1&lt;/i&gt;+ macrophages.,2025,10.3389/fcell.2025.1611663,https://pubmed.ncbi.nlm.nih.gov/40900730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,39916398,A 250-kb Microdeletion Identified in Chromosome 16 Is Associated With Non-Syndromic Sensorineural Hearing Loss in a South Indian Consanguineous Family.,2025,10.7874/jao.2024.00038,https://pubmed.ncbi.nlm.nih.gov/39916398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,38201793,"A Novel Approach for Glycero-(9,10-trioxolane)-Trialeate Incorporation into Poly(lactic acid)/Poly(ɛ-caprolactone) Blends for Biomedicine and Packaging.",2023,10.3390/polym16010128,https://pubmed.ncbi.nlm.nih.gov/38201793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,34562879,Compound Heterozygosity for OTOA Truncating Variant and Genomic Rearrangement Cause Autosomal Recessive Sensorineural Hearing Loss in an Italian Family.,2021,10.3390/audiolres11030041,https://pubmed.ncbi.nlm.nih.gov/34562879/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,36080553,"Improvement of the Structure and Physicochemical Properties of Polylactic Acid Films by Addition of Glycero-(9,10-trioxolane)-Trialeate.",2022,10.3390/polym14173478,https://pubmed.ncbi.nlm.nih.gov/36080553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,34372120,"Effect of Glycero-(9,10-trioxolane)-trialeate on the Physicochemical Properties of Non-Woven Polylactic Acid Fiber Materials.",2021,10.3390/polym13152517,https://pubmed.ncbi.nlm.nih.gov/34372120/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,38254368,Comparative Blood Transcriptome Analysis of Semi-Natural and Controlled Environment Populations of Yangtze Finless Porpoise.,2024,10.3390/ani14020199,https://pubmed.ncbi.nlm.nih.gov/38254368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,37965461,Primary lipoblastic nerve sheath tumor in an inguinal lymph node mimicking metastatic tumor: a case report and literature review.,2023,10.3389/fonc.2023.1258769,https://pubmed.ncbi.nlm.nih.gov/37965461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,33753912,Is it time to report carrier state for recessive disorders in every microarray analysis?-A pilot model based on hearing loss genes deletions.,2021,10.1038/s41431-021-00856-3,https://pubmed.ncbi.nlm.nih.gov/33753912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,30740825,Clarification of glycosylphosphatidylinositol anchorage of OTOANCORIN and human OTOA variants associated with deafness.,2019,10.1002/humu.23719,https://pubmed.ncbi.nlm.nih.gov/30740825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,33492714,Molecular characterization of pathogenic OTOA gene conversions in hearing loss patients.,2021,10.1002/humu.24167,https://pubmed.ncbi.nlm.nih.gov/33492714/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,38894825,Whole Exome Sequencing of Non-Syndromic Hearing Loss Patients.,2024,10.18502/ijph.v53i2.14930,https://pubmed.ncbi.nlm.nih.gov/38894825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,35135489,Massive digital gene expression analysis reveals different predictive profiles for immune checkpoint inhibitor therapy between adenocarcinoma and squamous cell carcinoma of advanced lung cancer.,2022,10.1186/s12885-022-09264-2,https://pubmed.ncbi.nlm.nih.gov/35135489/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,25062256,Identification of copy number variants through whole-exome sequencing in autosomal recessive nonsyndromic hearing loss.,2014,10.1089/gtmb.2014.0121,https://pubmed.ncbi.nlm.nih.gov/25062256/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOA,ENSG00000155719,Unsafe,19088187,Genome-wide analysis of cancer/testis gene expression.,2008,10.1073/pnas.0810777105,https://pubmed.ncbi.nlm.nih.gov/19088187/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,42103221,OTOP2 proton channel couples luminal pH sensing to intestinal immune homeostasis.,2026,10.1016/j.jbc.2026.113105,https://pubmed.ncbi.nlm.nih.gov/42103221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,42600663,Human OTOP3 requires strong acidification for activation and exhibits mixed proton-anion permeation.,2026,10.1016/j.jbc.2026.113454,https://pubmed.ncbi.nlm.nih.gov/42600663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,42020305,Rare missense variants in &lt;i&gt;MYO7A&lt;/i&gt; and &lt;i&gt;OTOP2&lt;/i&gt; genes in a South Korean Meniere's disease cohort.,2026,10.1136/jmg-2025-111426,https://pubmed.ncbi.nlm.nih.gov/42020305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,42793272,Integrated Bioinformatics Identification and Multi-Dimensional Characterization of Diagnostic Hub Genes in Colorectal Cancer.,2026,10.3390/cimb48090916,https://pubmed.ncbi.nlm.nih.gov/42793272/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,42584809,BEST4⁺ cells: a potential hub of intestinal ion transport and diarrhea manipulation.,2026,10.1007/s44307-026-00126-7,https://pubmed.ncbi.nlm.nih.gov/42584809/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,39132149,Determination of the Immunomodulatory Role of OTOP2 in Colon Adenocarcinoma.,2024,10.7150/jca.95622,https://pubmed.ncbi.nlm.nih.gov/39132149/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,40931362,Single-cell atlas in the living fossil Yangtze sturgeon provides insight into the evolution of fish.,2025,10.1186/s13059-025-03764-7,https://pubmed.ncbi.nlm.nih.gov/40931362/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,41005986,CFTR High Expresser BEST4&lt;sup&gt;+&lt;/sup&gt; cells are pH-sensing neuropod cells: new implications for intestinal physiology and cystic fibrosis disease.,2025,10.1152/ajpcell.00082.2025,https://pubmed.ncbi.nlm.nih.gov/41005986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,37650127,Genome-wide methylation profiling identified methylated KCNA3 and OTOP2 as promising diagnostic markers for esophageal squamous cell carcinoma.,2024,10.1097/cm9.0000000000002832,https://pubmed.ncbi.nlm.nih.gov/37650127/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,39709429,"Correction: Non-invasive diagnosis of esophageal cancer by a simplified circulating cell-free DNA methylation assay targeting OTOP2 and KCNA3: a double-blinded, multicenter, prospective study.",2024,10.1186/s13045-024-01653-3,https://pubmed.ncbi.nlm.nih.gov/39709429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,38557358,BEST4+ cells in the intestinal epithelium.,2024,10.1152/ajpcell.00042.2024,https://pubmed.ncbi.nlm.nih.gov/38557358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,39484215,COADREADx: A comprehensive algorithmic dissection of colorectal cancer unravels salient biomarkers and actionable insights into its discrete progression.,2024,10.7717/peerj.18347,https://pubmed.ncbi.nlm.nih.gov/39484215/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,35418782,"OTOP2, Inversely Modulated by miR-3148, Inhibits CRC Cell Migration, Proliferation and Epithelial-Mesenchymal Transition: Evidence from Bioinformatics Data Mining and Experimental Verification.",2022,10.2147/cmar.s345299,https://pubmed.ncbi.nlm.nih.gov/35418782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,39179582,Structural mechanism of proton conduction in otopetrin proton channel.,2024,10.1038/s41467-024-51803-x,https://pubmed.ncbi.nlm.nih.gov/39179582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,38890756,"Non-invasive diagnosis of esophageal cancer by a simplified circulating cell-free DNA methylation assay targeting OTOP2 and KCNA3: a double-blinded, multicenter, prospective study.",2024,10.1186/s13045-024-01565-2,https://pubmed.ncbi.nlm.nih.gov/38890756/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,40011703,Preferential allosteric modulation of Otop1 channels by small molecule compounds.,2025,10.1038/s42003-025-07775-9,https://pubmed.ncbi.nlm.nih.gov/40011703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,37107589,Rare Coding Variants in Patients with Non-Syndromic Vestibular Dysfunction.,2023,10.3390/genes14040831,https://pubmed.ncbi.nlm.nih.gov/37107589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,37543577,Spatial tumour gene signature discriminates neoplastic from non-neoplastic compartments in colon cancer: unravelling predictive biomarkers for relapse.,2023,10.1186/s12967-023-04384-0,https://pubmed.ncbi.nlm.nih.gov/37543577/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,30652071,Wild-type p53 regulates OTOP2 transcription through DNA loop alteration of the promoter in colorectal cancer.,2019,10.1002/2211-5463.12554,https://pubmed.ncbi.nlm.nih.gov/30652071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,35639499,Inference of cell state transitions and cell fate plasticity from single-cell with MARGARET.,2022,10.1093/nar/gkac412,https://pubmed.ncbi.nlm.nih.gov/35639499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,32555404,RNA sequencing of corneas from two keratoconus patient groups identifies potential biomarkers and decreased NRF2-antioxidant responses.,2020,10.1038/s41598-020-66735-x,https://pubmed.ncbi.nlm.nih.gov/32555404/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTOP2,ENSG00000183034,Unsafe,30443032,RNA sequencing-based analysis of the laying hen uterus revealed the novel genes and biological pathways involved in the eggshell biomineralization.,2018,10.1038/s41598-018-35203-y,https://pubmed.ncbi.nlm.nih.gov/30443032/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,42234541,Brain Distribution of Orthopedia (Otp) Transcription Factor in Bony Fish: A Comparative Neuroanatomical Perspective.,2026,10.1002/cne.70174,https://pubmed.ncbi.nlm.nih.gov/42234541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,39562620,"A new cancer/testis long noncoding RNA, the OTP-AS1 RNA.",2024,10.1038/s41598-024-80065-2,https://pubmed.ncbi.nlm.nih.gov/39562620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,41840852,Disruption of the developmental factor Otp in the adult male forebrain reveals its diverse physiological functions.,2026,10.1210/endocr/bqag029,https://pubmed.ncbi.nlm.nih.gov/41840852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,42767405,"OTP, CD44, and Ki-67 Immunohistochemistry to Predict Prognosis in Preoperative Lung Neuroendocrine Tumor Biopsy Specimens.",2026,10.1016/j.modpat.2026.101088,https://pubmed.ncbi.nlm.nih.gov/42767405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,41489019,"Analysis of SCLC subtype markers (ASCL1, NEUROD1, POU2F3, YAP1), DLL3, OTP, and TTF1 in 300 lung carcinoids and enteropancreatic neuroendocrine tumours.",2026,10.1111/his.70081,https://pubmed.ncbi.nlm.nih.gov/41489019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,42639261,Clinical utility of molecular profiling in rare lung neuroendocrine neoplasms.,2026,10.3389/fonc.2026.1840985,https://pubmed.ncbi.nlm.nih.gov/42639261/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,42133905,Multicenter Cohort Study of Original or Substitute Systemic Therapy With or Without Brain Radiotherapy for Extensive-Stage Small Cell Lung Cancer With Brain-Only Progression After First-Line Treatment.,2026,10.1200/jco-25-02536,https://pubmed.ncbi.nlm.nih.gov/42133905/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,40973492,Procedure duration predicts outcomes more than prehospital delay in endovascular stroke treatment.,2026,10.1136/jnis-2025-023906,https://pubmed.ncbi.nlm.nih.gov/40973492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,40269137,"Author Correction: A new cancer/testis long noncoding RNA, the OTP-AS1 RNA.",2025,10.1038/s41598-025-98337-w,https://pubmed.ncbi.nlm.nih.gov/40269137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,42896742,Heterogeneity in Time-Outcome Associations After Endovascular Thrombectomy: A Binational Registry Study.,2026,10.1016/j.jstrokecerebrovasdis.2026.108770,https://pubmed.ncbi.nlm.nih.gov/42896742/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,41196447,"Phenotypic Landscape of Pulmonary Neuroendocrine Tumors: Subtyped by OTP/ASCL1 Expression Correlated with Histology, Hormones and Outcome.",2025,10.1007/s12022-025-09882-z,https://pubmed.ncbi.nlm.nih.gov/41196447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,39813316,&lt;i&gt;Orthopedia&lt;/i&gt; regulates melanocortin 4 receptor transcription and energy homeostasis.,2025,10.1126/scitranslmed.adr6459,https://pubmed.ncbi.nlm.nih.gov/39813316/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,42780969,Endobronchial typical carcinoid with secondary Aspergillus fumigatus colonization: Avoiding a diagnostic pitfall in bronchoscopic biopsy.,2026,10.1007/s13691-026-00912-z,https://pubmed.ncbi.nlm.nih.gov/42780969/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,42647987,Targeting EP2 overcomes osimertinib-tolerant persisters through metabolic and inflammatory reprogramming in non-small cell lung cancer.,2026,10.1016/j.intimp.2026.117313,https://pubmed.ncbi.nlm.nih.gov/42647987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,42401207,Lung Carcinoids with Sustentacular Cells and Low Keratin Expression: A Common yet Underrecognized Phenomenon with Diagnostic and Biological Implications.,2026,10.1016/j.modpat.2026.101037,https://pubmed.ncbi.nlm.nih.gov/42401207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,40532667,Evolutionary Expression of the Orthopedia Transcription Factor in the Alar Hypothalamus: Implications for Amygdala Formation across Vertebrates.,2026,10.1159/000546877,https://pubmed.ncbi.nlm.nih.gov/40532667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,41923847,Effect of oil-enriched tomato powder and simvastatin on yolk cholesterol and color in laying hens.,2025,10.5455/javar.2025.l999,https://pubmed.ncbi.nlm.nih.gov/41923847/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,40177299,Development of catecholaminergic neurons of Otp-lineage in the medial extended amygdala and related forebrain centers.,2025,10.3389/fnana.2025.1553952,https://pubmed.ncbi.nlm.nih.gov/40177299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,42348472,Hypoperfusion Intensity Ratio as a Predictive Marker in Pre-Endovascular Treatment Perfusion Magnetic Resonance Image for Acute Middle Cerebral Artery Occlusion with Intracranial Atherosclerosis.,2026,10.1159/000552144,https://pubmed.ncbi.nlm.nih.gov/42348472/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,41269691,Leveraging the 72-Hour Rule Change to Support Transition From Hospital to Opioid Treatment Program.,2025,10.1001/jamanetworkopen.2025.44996,https://pubmed.ncbi.nlm.nih.gov/41269691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,42531827,Engineering a tumor-homing ZIF-8 nanoplatform for safe and synergistic immunotherapy of osteosarcoma.,2026,10.1016/j.bioadv.2026.215070,https://pubmed.ncbi.nlm.nih.gov/42531827/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,41895698,The impact of a continuum of care intervention from prevention to treatment on child wasting compared with usual community group activities: a cluster-randomized controlled trial in Mali.,2026,10.1016/j.ajcnut.2026.101294,https://pubmed.ncbi.nlm.nih.gov/41895698/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,42639664,A Clinic-Level Intervention May Promote Methadone Patients' Consistent Daily Adherence to Their Dosing Schedules.,2026,10.1177/29767342261476896,https://pubmed.ncbi.nlm.nih.gov/42639664/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,42427185,Reimagining Methadone Clinics: A Case For Integrating Risk Reduction to Address the Complex Realities of Opioid Use Disorder.,2026,10.1177/29767342261463988,https://pubmed.ncbi.nlm.nih.gov/42427185/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,41919133,Influence of interhospital transfer on endovascular thrombectomy outcome in acute ischemic stroke patients: an analysis of the TREAT-AIS registry.,2026,10.3389/fneur.2026.1743928,https://pubmed.ncbi.nlm.nih.gov/41919133/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,42764789,"Community-Based Outpatient Therapeutic Program Implementation in Central Gondar Zone, Northwest Ethiopia: A Process Evaluation Using Access and Implementation Fidelity Frameworks.",2026,10.1111/mcn.70243,https://pubmed.ncbi.nlm.nih.gov/42764789/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,42163934,Rapid hepatitis C test and treat with peer support at opioid treatment programs (RAPID HCV): a hybrid effectiveness-implementation type 1 randomized control trial.,2026,10.1016/j.lana.2026.101439,https://pubmed.ncbi.nlm.nih.gov/42163934/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,41525682,Acceptability of and Implementation Supports for Video Directly Observed Treatment to Enhance Methadone Dosing Flexibility in a Multisite Opioid Treatment Program: Qualitative Rapid Needs Assessment Study.,2026,10.2196/84162,https://pubmed.ncbi.nlm.nih.gov/41525682/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,40818961,"Clinicians' attitudes and knowledge of medicinal cannabis in opioid dependence treatment clinics in New South Wales, Australia.",2025,10.1186/s42238-025-00315-6,https://pubmed.ncbi.nlm.nih.gov/40818961/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,39976595,"Change in Cigarette, Other Tobacco Product, and Cannabis Use Among Individuals Who Used or Did Not Use Cannabis During a Smoking Cessation Trial.",2025,10.1093/ntr/ntaf045,https://pubmed.ncbi.nlm.nih.gov/39976595/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,41634964,Explaining Variation in VA Opioid Treatment Program Clinical Practice Following Regulatory Reform: A Qualitative Study.,2026,10.1177/29767342251405994,https://pubmed.ncbi.nlm.nih.gov/41634964/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,42082629,A framework for quantum-secure communications in cyber-physical control systems with experimental demonstration in nuclear a reactor.,2026,10.1038/s41598-026-49514-y,https://pubmed.ncbi.nlm.nih.gov/42082629/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,40262251,Development and validation of a CT-based radiomics machine learning model for differentiating immune-related interstitial pneumonia.,2025,10.1016/j.intimp.2025.114681,https://pubmed.ncbi.nlm.nih.gov/40262251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,42343429,"""How are we going to be able to pull that off?"": staff perspectives on the early implementation of mobile medication units in New York State.",2026,10.1186/s13722-026-00694-y,https://pubmed.ncbi.nlm.nih.gov/42343429/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,41111626,Enhancing Police Training Through Biomechanical Analysis and Wearable Technology - OTP.,2025,10.4103/ijoem.ijoem_123_24,https://pubmed.ncbi.nlm.nih.gov/41111626/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,41276178,Retention among Medicaid beneficiaries in opioid treatment programs in California.,2026,10.1016/j.josat.2025.209837,https://pubmed.ncbi.nlm.nih.gov/41276178/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTP,ENSG00000171540,Unsafe,40852656,The linkage between opioid treatment programs and recovery community centers: results of a survey of OTP directors.,2025,10.3389/fpubh.2025.1532374,https://pubmed.ncbi.nlm.nih.gov/40852656/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,42323308,Targeting OTUD7A-HINT1 deubiquitination activates mTOR signaling for CNS regeneration.,2026,10.1038/s41419-026-09005-4,https://pubmed.ncbi.nlm.nih.gov/42323308/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,41268652,OTUD7a Accelerates Pathological Cardiac Hypertrophy via TAK1 Activation.,2026,10.1161/circresaha.125.326647,https://pubmed.ncbi.nlm.nih.gov/41268652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,41422226,Suppressing the OTUD7A/KDM5B/GABPA axis enhances the sensitivity of cisplatin through inducing ferroptosis in KRAS-mutant LUAD.,2025,10.1038/s41419-025-08337-x,https://pubmed.ncbi.nlm.nih.gov/41422226/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,38716888,Deubiquitinases in muscle physiology and disorders.,2024,10.1042/bst20230562,https://pubmed.ncbi.nlm.nih.gov/38716888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,36604605,Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.,2023,10.1038/s41380-022-01937-5,https://pubmed.ncbi.nlm.nih.gov/36604605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,40049827,Genetic counseling of prenatally detected familial 15q13.2q13.3 microdeletion encompassing CHRNA7 and OTUD7A with asymptomatic carriers in the family.,2025,10.1016/j.tjog.2024.12.015,https://pubmed.ncbi.nlm.nih.gov/40049827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,42286492,Diversity of molecular karyotypes of 234 pediatric patients with autism spectrum disorder in chromosomal microarray analysis.,2026,10.1186/s12888-026-08263-y,https://pubmed.ncbi.nlm.nih.gov/42286492/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,41123664,Prenatal diagnosis of 15q13.3 deletion and duplication syndrome: what do we tell the prospective parents?,2025,10.1007/s00404-025-08150-z,https://pubmed.ncbi.nlm.nih.gov/41123664/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,40943430,Chromosome 15q Structural Variants Associated with Syndromic Autism Spectrum Disorder: Clinical and Genomic Insights from Three Case Reports in a Brazilian Reference Center.,2025,10.3390/ijms26178509,https://pubmed.ncbi.nlm.nih.gov/40943430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,35931052,Loss of function of OTUD7A in the schizophrenia- associated 15q13.3 deletion impairs synapse development and function in human neurons.,2022,10.1016/j.ajhg.2022.07.001,https://pubmed.ncbi.nlm.nih.gov/35931052/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,34060252,SPOP and OTUD7A Control EWS-FLI1 Protein Stability to Govern Ewing Sarcoma Growth.,2021,10.1002/advs.202004846,https://pubmed.ncbi.nlm.nih.gov/34060252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,39095438,Phenotype prediction using biologically interpretable neural networks on multi-cohort multi-omics data.,2024,10.1038/s41540-024-00405-w,https://pubmed.ncbi.nlm.nih.gov/39095438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,31997314,Report of the first patient with a homozygous OTUD7A variant responsible for epileptic encephalopathy and related proteasome dysfunction.,2020,10.1111/cge.13709,https://pubmed.ncbi.nlm.nih.gov/31997314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,31699778,Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne.,2019,10.1101/gad.332395.119,https://pubmed.ncbi.nlm.nih.gov/31699778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,33932528,TNIP2 mediates GRβ-promoted inflammation and is associated with severity of major depressive disorder.,2021,10.1016/j.bbi.2021.04.021,https://pubmed.ncbi.nlm.nih.gov/33932528/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,29395074,OTUD7A Regulates Neurodevelopmental Phenotypes in the 15q13.3 Microdeletion Syndrome.,2018,10.1016/j.ajhg.2018.01.006,https://pubmed.ncbi.nlm.nih.gov/29395074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,33785025,"Mice with mutations in Trpm1, a gene in the locus of 15q13.3 microdeletion syndrome, display pronounced hyperactivity and decreased anxiety-like behavior.",2021,10.1186/s13041-021-00749-y,https://pubmed.ncbi.nlm.nih.gov/33785025/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,29395075,Otud7a Knockout Mice Recapitulate Many Neurological Features of 15q13.3 Microdeletion Syndrome.,2018,10.1016/j.ajhg.2018.01.005,https://pubmed.ncbi.nlm.nih.gov/29395075/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,36084604,Peripheral immune challenges elicit differential up-regulation of hippocampal cytokine and chemokine mRNA expression in a mouse model of the 15q13.3 microdeletion syndrome.,2022,10.1016/j.cyto.2022.156005,https://pubmed.ncbi.nlm.nih.gov/36084604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,32712126,"Molecular, physiological and behavioral characterization of the heterozygous Df[h15q13]/+ mouse model associated with the human 15q13.3 microdeletion syndrome.",2020,10.1016/j.brainres.2020.147024,https://pubmed.ncbi.nlm.nih.gov/32712126/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,27459725,"15q13.3 homozygous knockout mouse model display epilepsy-, autism- and schizophrenia-related phenotypes.",2016,10.1038/tp.2016.125,https://pubmed.ncbi.nlm.nih.gov/27459725/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OTUD7A,ENSG00000169918,Unsafe,23650146,A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.,2013,10.1002/gepi.21731,https://pubmed.ncbi.nlm.nih.gov/23650146/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OXCT2,ENSG00000198754,Unsafe,40649876,Age-Associated Proteomic Changes in Human Spermatozoa.,2025,10.3390/ijms26136099,https://pubmed.ncbi.nlm.nih.gov/40649876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OXCT2,ENSG00000198754,Unsafe,35983595,CHAC1 as a novel biomarker for distinguishing alopecia from other dermatological diseases and determining its severity.,2022,10.1049/syb2.12048,https://pubmed.ncbi.nlm.nih.gov/35983595/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OXCT2,ENSG00000198754,Unsafe,15028287,"Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b.",2004,10.1016/j.ygeno.2003.09.018,https://pubmed.ncbi.nlm.nih.gov/15028287/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
OXCT2,ENSG00000198754,Unsafe,11756565,Cloning and characterization of a human orthologue of testis-specific succinyl CoA: 3-oxo acid CoA transferase (Scot-t) cDNA.,2002,10.1093/molehr/8.1.16,https://pubmed.ncbi.nlm.nih.gov/11756565/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABIR3,ENSG00000156500,Unsafe,40932096,"Low-Allele-Frequency Somatic Variants in a Cohort of Sporadic Saccular ""Berry"" Cerebral Aneurysms.",2025,10.1161/jaha.123.032483,https://pubmed.ncbi.nlm.nih.gov/40932096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABIR3,ENSG00000156500,Unsafe,37686605,Extracellular Vesicles-A Source of RNA Biomarkers for the Detection of Breast Cancer in Liquid Biopsies.,2023,10.3390/cancers15174329,https://pubmed.ncbi.nlm.nih.gov/37686605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABIR3,ENSG00000156500,Unsafe,35178089,Identification and Validation of a Hypoxia-Immune-Based Prognostic mRNA Signature for Oral Squamous Cell Carcinoma.,2022,10.1155/2022/5286251,https://pubmed.ncbi.nlm.nih.gov/35178089/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABIR3,ENSG00000156500,Unsafe,25586786,Differentiation of primordial germ cells from induced pluripotent stem cells of primary ovarian insufficiency.,2015,10.1093/humrep/deu358,https://pubmed.ncbi.nlm.nih.gov/25586786/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,41249135,PABPC3 drives ovarian cancer metastasis and drug sensitivity by downregulating CLDN1 expression.,2025,10.1038/s41419-025-08151-5,https://pubmed.ncbi.nlm.nih.gov/41249135/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,40254460,"Mice lacking two testis-specific cytoplasmic poly(A)-binding proteins, PABPC2 and PABPC6, exhibit normal spermatogenesis and fertility.",2025,10.1262/jrd.2025-012,https://pubmed.ncbi.nlm.nih.gov/40254460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,37176068,Human Tissues Exhibit Diverse Composition of Translation Machinery.,2023,10.3390/ijms24098361,https://pubmed.ncbi.nlm.nih.gov/37176068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,41776682,The related EIF4G3 and EIF4G4 initiation factors from Leishmania: dissimilar modes of action during translation revealed by a comparative proteomic approach.,2026,10.1186/s13071-026-07297-1,https://pubmed.ncbi.nlm.nih.gov/41776682/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,38058264,Disulfidptosis-related PABPC3 promotes tumor progression and inhibits immune activity in osteosarcoma.,2024,10.1002/jgm.3641,https://pubmed.ncbi.nlm.nih.gov/38058264/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,38281153,"Intronless Pabpc6 encodes a testis-specific, cytoplasmic poly(A)-binding protein but is dispensable for spermatogenesis in the mouse†.",2024,10.1093/biolre/ioae017,https://pubmed.ncbi.nlm.nih.gov/38281153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,39449424,Network Pharmacology Approaches Used to Identify Therapeutic Molecules for Chronic Venous Disease Based on Potential miRNA Biomarkers.,2024,10.3390/jox14040083,https://pubmed.ncbi.nlm.nih.gov/39449424/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,39809219,Identification and validation of a novel defined stress granule-related gene signature for predicting the prognosis of ovarian cancer via bioinformatics analysis.,2024,10.1097/md.0000000000040608,https://pubmed.ncbi.nlm.nih.gov/39809219/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,40197849,Whole Exome Sequencing Study Identifies Distinct Characteristics of Transformed Small Cell Lung Cancer With EGFR Mutation Compared to De Novo Small Cell and Primary Non-Small Cell Lung Cancers.,2025,10.1002/cam4.70838,https://pubmed.ncbi.nlm.nih.gov/40197849/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,40441397,Association of Fc gamma-binding protein rs1464897604 polymorphism with bronchiolitis obliterans syndrome in lung transplant recipients.,2025,10.1016/j.healun.2025.05.001,https://pubmed.ncbi.nlm.nih.gov/40441397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,35456240,Identification of Potentially Pathogenic Variants Associated with Recurrence in Medication-Related Osteonecrosis of the Jaw (MRONJ) Patients Using Whole-Exome Sequencing.,2022,10.3390/jcm11082145,https://pubmed.ncbi.nlm.nih.gov/35456240/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,38328595,The Influence of Blue Light Exposure on Reconstructed 3-Dimensional Skin Model: Molecular Changes and Gene Expression Profile.,2024,10.1016/j.xjidi.2023.100252,https://pubmed.ncbi.nlm.nih.gov/38328595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,33744966,MKRN3-mediated ubiquitination of Poly(A)-binding proteins modulates the stability and translation of GNRH1 mRNA in mammalian puberty.,2021,10.1093/nar/gkab155,https://pubmed.ncbi.nlm.nih.gov/33744966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,34311674,DNA methylome in visceral adipose tissue can discriminate patients with and without colorectal cancer.,2022,10.1080/15592294.2021.1950991,https://pubmed.ncbi.nlm.nih.gov/34311674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,26843391,"The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia.",2016,10.1007/s10815-016-0654-z,https://pubmed.ncbi.nlm.nih.gov/26843391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,34705820,"Identification of novel proteins and mRNAs differentially bound to the Leishmania Poly(A) Binding Proteins reveals a direct association between PABP1, the RNA-binding protein RBP23 and mRNAs encoding ribosomal proteins.",2021,10.1371/journal.pntd.0009899,https://pubmed.ncbi.nlm.nih.gov/34705820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,33562109,Characterization of ALBA Family Expression and Localization in Arabidopsis thaliana Generative Organs.,2021,10.3390/ijms22041652,https://pubmed.ncbi.nlm.nih.gov/33562109/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,36229065,Whole-exome sequencing of epithelial ovarian carcinomas differing in resistance to platinum therapy.,2022,10.26508/lsa.202201551,https://pubmed.ncbi.nlm.nih.gov/36229065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,35041720,Integration of gene co-expression analysis and multi-class SVM specifies the functional players involved in determining the fate of HTLV-1 infection toward the development of cancer (ATLL) or neurological disorder (HAM/TSP).,2022,10.1371/journal.pone.0262739,https://pubmed.ncbi.nlm.nih.gov/35041720/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,35394261,Establishment and characterization of the third non-functional human pancreatic neuroendocrine tumor cell line.,2022,10.1007/s13577-022-00696-3,https://pubmed.ncbi.nlm.nih.gov/35394261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC3,ENSG00000151846,Unsafe,11328870,Human testis expresses a specific poly(A)-binding protein.,2001,10.1093/nar/29.9.1872,https://pubmed.ncbi.nlm.nih.gov/11328870/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC4L,ENSG00000254535,Unsafe,42113877,Playing both sides - Epstein-Barr Virus accumulates select cellular transcripts to counter virus-mediated host shut-off in lytic cells.,2026,10.1371/journal.ppat.1014211,https://pubmed.ncbi.nlm.nih.gov/42113877/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC4L,ENSG00000254535,Unsafe,40005725,The Joint Contribution of Host Genetics and Probiotics to Pig Growth Performance.,2025,10.3390/microorganisms13020358,https://pubmed.ncbi.nlm.nih.gov/40005725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC4L,ENSG00000254535,Unsafe,31537871,Segregation and potential functional impact of a rare stop-gain PABPC4L variant in familial atypical Parkinsonism.,2019,10.1038/s41598-019-50102-6,https://pubmed.ncbi.nlm.nih.gov/31537871/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PABPC4L,ENSG00000254535,Unsafe,24529801,Rare copy number variation in treatment-resistant major depressive disorder.,2014,10.1016/j.biopsych.2013.10.028,https://pubmed.ncbi.nlm.nih.gov/24529801/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE2B,ENSG00000238269,Unsafe,37780629,Exploring the role of macrophages in the progression from atypical hyperplasia to endometrial carcinoma through single-cell transcriptomics and bulk transcriptomics analysis.,2023,10.3389/fendo.2023.1198944,https://pubmed.ncbi.nlm.nih.gov/37780629/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE2B,ENSG00000238269,Unsafe,40996939,"POU4F1 Drives Colorectal Cancer Progression by Promoting Cell Proliferation, Metastasis, and Chemoresistance.",2026,10.1159/000548266,https://pubmed.ncbi.nlm.nih.gov/40996939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE2B,ENSG00000238269,Unsafe,28742074,Untargeted screening for novel autoantibodies with prognostic value in first-episode psychosis.,2017,10.1038/tp.2017.160,https://pubmed.ncbi.nlm.nih.gov/28742074/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,41172808,"PAGE4, upregulated in a novel iPSC-derived hepatoblastoma model, promotes hepatoblastoma progression.",2025,10.1016/j.bbrc.2025.152824,https://pubmed.ncbi.nlm.nih.gov/41172808/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,42270938,Single-cell transcriptomics reveals differences between chorionic and basal plate cytotrophoblasts and 2D-cultured trophoblast stem cells.,2026,10.1038/s42003-026-10460-0,https://pubmed.ncbi.nlm.nih.gov/42270938/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,35633887,The Prostate-Associated Gene 4 (PAGE4) Could Play a Role in the Development of Benign Prostatic Hyperplasia under Oxidative Stress.,2022,10.1155/2022/7041739,https://pubmed.ncbi.nlm.nih.gov/35633887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,32698014,Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.,2020,10.1016/j.celrep.2020.107922,https://pubmed.ncbi.nlm.nih.gov/32698014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,30658679,PAGE4 promotes prostate cancer cells survive under oxidative stress through modulating MAPK/JNK/ERK pathway.,2019,10.1186/s13046-019-1032-3,https://pubmed.ncbi.nlm.nih.gov/30658679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,29914187,Prostate-Associated Gene 4 (PAGE4): Leveraging the Conformational Dynamics of a Dancing Protein Cloud as a Therapeutic Target.,2018,10.3390/jcm7060156,https://pubmed.ncbi.nlm.nih.gov/29914187/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,27270343,"Prostate-associated gene 4 (PAGE4), an intrinsically disordered cancer/testis antigen, is a novel therapeutic target for prostate cancer.",2016,10.4103/1008-682x.181818,https://pubmed.ncbi.nlm.nih.gov/27270343/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,35059032,Protein conformational dynamics and phenotypic switching.,2021,10.1007/s12551-021-00858-x,https://pubmed.ncbi.nlm.nih.gov/35059032/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,32003504,Stromal-epithelial interactions in prostate cancer: Overexpression of PAGE4 in stromal cells inhibits the invasive ability of epithelial cells.,2020,10.1002/jcb.29664,https://pubmed.ncbi.nlm.nih.gov/32003504/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,33652914,"Coupled Feedback Loops Involving PAGE4, EMT and Notch Signaling Can Give Rise to Non-genetic Heterogeneity in Prostate Cancer Cells.",2021,10.3390/e23030288,https://pubmed.ncbi.nlm.nih.gov/33652914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,28362316,"Cancer/Testis Antigens: ""Smart"" Biomarkers for Diagnosis and Prognosis of Prostate and Other Cancers.",2017,10.3390/ijms18040740,https://pubmed.ncbi.nlm.nih.gov/28362316/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,28289210,Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity.,2017,10.1073/pnas.1700082114,https://pubmed.ncbi.nlm.nih.gov/28289210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,25374899,Prostate-associated gene 4 (PAGE4) protects cells against stress by elevating p21 and suppressing reactive oxygen species production.,2013,,https://pubmed.ncbi.nlm.nih.gov/25374899/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,30813315,Structural and Dynamical Order of a Disordered Protein: Molecular Insights into Conformational Switching of PAGE4 at the Systems Level.,2019,10.3390/biom9020077,https://pubmed.ncbi.nlm.nih.gov/30813315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,24559171,"Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway.",2014,10.1021/bi500013w,https://pubmed.ncbi.nlm.nih.gov/24559171/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,37565899,Single-cell and bulk RNA sequencing reveal cancer-associated fibroblast heterogeneity and a prognostic signature in prostate cancer.,2023,10.1097/md.0000000000034611,https://pubmed.ncbi.nlm.nih.gov/37565899/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,26317029,A Panel of Cancer Testis Antigens and Clinical Risk Factors to Predict Metastasis in Colorectal Cancer.,2014,10.1155/2014/272683,https://pubmed.ncbi.nlm.nih.gov/26317029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,26242913,Phosphorylation-induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen.,2015,10.1074/jbc.m115.658583,https://pubmed.ncbi.nlm.nih.gov/26242913/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,24263171,"The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation.",2014,10.1016/j.bbadis.2013.11.014,https://pubmed.ncbi.nlm.nih.gov/24263171/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,21357425,The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a highly intrinsically disordered protein.,2011,10.1074/jbc.m110.210765,https://pubmed.ncbi.nlm.nih.gov/21357425/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,17397028,Identification of cytotoxic T-lymphocyte epitope(s) and its agonist epitope(s) of a novel target for vaccine therapy (PAGE4).,2007,10.1002/ijc.22698,https://pubmed.ncbi.nlm.nih.gov/17397028/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,30413085,Single Molecule FRET: A Powerful Tool to Study Intrinsically Disordered Proteins.,2018,10.3390/biom8040140,https://pubmed.ncbi.nlm.nih.gov/30413085/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,15459874,[Adaptive immunotherapy of the advanced prostate cancer - cancer testis antigen (CTA) as possible target antigens].,2004,10.1055/s-2004-818510,https://pubmed.ncbi.nlm.nih.gov/15459874/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,21917134,Cancer/Testis Antigens as potential predictors of biochemical recurrence of prostate cancer following radical prostatectomy.,2011,10.1186/1479-5876-9-153,https://pubmed.ncbi.nlm.nih.gov/21917134/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,26747525,IL-10 and integrin signaling pathways are associated with head and neck cancer progression.,2016,10.1186/s12864-015-2359-6,https://pubmed.ncbi.nlm.nih.gov/26747525/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,21308735,Creatine kinase brain overexpression protects colorectal cells from various metabolic and non-metabolic stresses.,2011,10.1002/jcb.23020,https://pubmed.ncbi.nlm.nih.gov/21308735/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,12489849,PAGE4 is a cytoplasmic protein that is expressed in normal prostate and in prostate cancers.,2002,,https://pubmed.ncbi.nlm.nih.gov/12489849/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAGE4,ENSG00000101951,Unsafe,9724777,"PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus.",1998,10.1073/pnas.95.18.10757,https://pubmed.ncbi.nlm.nih.gov/9724777/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,42192776,CCL2 and PAK6 as Candidate Biomarkers of Neuroinflammation in Parkinson's Disease: An Integrated Machine Learning and Single-Nucleus Transcriptomic Study.,2026,10.3390/brainsci16050463,https://pubmed.ncbi.nlm.nih.gov/42192776/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,41927885,PAK5 drives vascular remodeling in hypoxic pulmonary hypertension via Drp1-dependent mitochondrial midzone division.,2026,10.1038/s41598-026-46809-y,https://pubmed.ncbi.nlm.nih.gov/41927885/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,41097710,Prognostic and Immunomodulatory Roles of PAK6 in Colorectal Cancer Through Integrative Transcriptomic and Clinical Analysis.,2025,10.3390/cancers17193183,https://pubmed.ncbi.nlm.nih.gov/41097710/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,41490050,PAK5 Promotes Esophageal Squamous Cell Carcinoma Progression Revealed by Transcriptomic Profiling.,2025,10.3791/69085,https://pubmed.ncbi.nlm.nih.gov/41490050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,40708824,P21 activated kinase 6: a promising tool for predicting small cell lung cancer diagnosis and treatment response.,2025,10.7717/peerj.19714,https://pubmed.ncbi.nlm.nih.gov/40708824/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,42667124,An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development.,2026,10.1096/fj.202600627rr,https://pubmed.ncbi.nlm.nih.gov/42667124/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,41834498,PAK5-Mediated Suppression of β-Hydroxybutyrate Production Promotes Breast Cancer Metastasis and Can Be Overcome with Ketogenic Diet.,2026,10.1158/0008-5472.can-25-2174,https://pubmed.ncbi.nlm.nih.gov/41834498/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,42134501,Buyang Huanwu decoction promotes neurological recovery after ischemic stroke by activating the Akt/PAK5/SNPH axis to enhance mitochondrial recruitment and axonal remodeling.,2026,10.1016/j.jep.2026.121860,https://pubmed.ncbi.nlm.nih.gov/42134501/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,40650306,Identification of a PAK6-Mediated MDM2/p21 Axis That Modulates Survival and Cell Cycle Control of Drug-Resistant Stem/Progenitor Cells in Chronic Myeloid Leukemia.,2025,10.3390/ijms26136533,https://pubmed.ncbi.nlm.nih.gov/40650306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,42186039,"Glycolytic reprogramming in endometriosis: molecular mechanisms, immune modulation, and non-hormonal therapeutic opportunities.",2026,10.1186/s12905-026-04570-4,https://pubmed.ncbi.nlm.nih.gov/42186039/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,41435694,HNRNPC lactylation promotes pancreatic cancer progression through mediating the alternative splicing of PAK6.,2026,10.1016/j.canlet.2025.218230,https://pubmed.ncbi.nlm.nih.gov/41435694/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,41584036,Dysregulation of SRSF11 in Cancer: Mechanistic Insights and Biomarker Potential for Diagnosis and Therapy.,2026,10.7150/jca.123791,https://pubmed.ncbi.nlm.nih.gov/41584036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,42299353,Proteomics in myelodysplastic syndromes: towards novel prognostic and diagnostic biomarkers.,2026,10.11613/bm.2026.020504,https://pubmed.ncbi.nlm.nih.gov/42299353/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,40837866,Newly Identified Genetic Associations of Alzheimer Disease by Conditional Selective Inference: Potential Implications for the Tau Hypothesis.,2025,10.1177/11779322251358309,https://pubmed.ncbi.nlm.nih.gov/40837866/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,42816601,Single-cell profiling and genetic regulation of alternative polyadenylation in the human brain.,2026,10.1038/s41588-026-02758-w,https://pubmed.ncbi.nlm.nih.gov/42816601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,41101234,PAK6 drives tumor microenvironment remodeling in nasopharyngeal carcinoma with lymph node necrosis: implications for distant metastasis and survival.,2025,10.1016/j.intimp.2025.115662,https://pubmed.ncbi.nlm.nih.gov/41101234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,40258843,PAK5 promotes the trastuzumab resistance by increasing HER2 nuclear accumulation in HER2-positive breast cancer.,2025,10.1038/s41419-025-07657-2,https://pubmed.ncbi.nlm.nih.gov/40258843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,38640169,Prospective Role of PAK6 and 14-3-3γ as Biomarkers for Parkinson's Disease.,2024,10.3233/jpd-230402,https://pubmed.ncbi.nlm.nih.gov/38640169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,42450323,Systemic Drug Effects in Vortioxetine-Induced Time-Series Datasets.,2026,10.3390/ijms27136058,https://pubmed.ncbi.nlm.nih.gov/42450323/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,40694989,PUM1 enhances PAK6 mRNA stability and contributes to growth and ferroptosis resistance in lung adenocarcinoma cells.,2025,10.1016/j.prp.2025.156094,https://pubmed.ncbi.nlm.nih.gov/40694989/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,40876424,The role and mechanism of PAK5 in the development and immunotherapy of oral squamous cell carcinoma.,2025,10.1016/j.intimp.2025.115406,https://pubmed.ncbi.nlm.nih.gov/40876424/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,41832487,CD93-targeted resveratrol-loaded PLGA nanoparticles remodel CD8⁺ T cell metabolism through AIF-mediated oxidative phosphorylation to overcome lung cancer immunotherapy resistance.,2026,10.1186/s12951-026-04216-5,https://pubmed.ncbi.nlm.nih.gov/41832487/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,42691184,Psilocybin prevents chemotherapy-induced peripheral neuropathy through mitochondrial trafficking preservation.,2026,10.1126/science.aec6116,https://pubmed.ncbi.nlm.nih.gov/42691184/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,40757418,Identification of Key Lactylation-Related Genes and Their Relevance to the Connection Between Parkinson's Disease and the Immune System Through Integrated Bioinformatics Analysis.,2025,10.1096/fj.202500823r,https://pubmed.ncbi.nlm.nih.gov/40757418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,39696440,miR-3191 promotes the proliferation and metastasis of hepatocellular carcinoma via regulating PAK6.,2024,10.1186/s13027-024-00628-w,https://pubmed.ncbi.nlm.nih.gov/39696440/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,40234614,Dual STAT3/STAT5 inhibition as a novel treatment strategy in T-prolymphocytic leukemia.,2025,10.1038/s41375-025-02577-8,https://pubmed.ncbi.nlm.nih.gov/40234614/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,39233332,Ethanol extract of Vanilla planifolia stems reduces PAK6 expression and induces cell death in glioblastoma cells.,2024,10.1111/jcmm.70065,https://pubmed.ncbi.nlm.nih.gov/39233332/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,42303781,Omics signature of new-onset mild cognitive impairment and dementia in a population-based study.,2026,10.1038/s41598-026-58117-6,https://pubmed.ncbi.nlm.nih.gov/42303781/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,40288982,[Prediction of immunotherapy targets for chronic cerebral hypoperfusion by bioinformatics method].,2025,10.7507/1001-5515.202409037,https://pubmed.ncbi.nlm.nih.gov/40288982/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,41782681,Stratified signaling network remodeling of kinase-transcription factors' interactions in Parkinson's disease.,2026,10.1093/bioadv/vbag059,https://pubmed.ncbi.nlm.nih.gov/41782681/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,35902562,PAK6 promotes homologous-recombination to enhance chemoresistance to oxaliplatin through ATR/CHK1 signaling in gastric cancer.,2022,10.1038/s41419-022-05118-8,https://pubmed.ncbi.nlm.nih.gov/35902562/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,36272033,SLC6A14 facilitates epithelial cell ferroptosis via the C/EBPβ-PAK6 axis in ulcerative colitis.,2022,10.1007/s00018-022-04594-7,https://pubmed.ncbi.nlm.nih.gov/36272033/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,11773441,AR and ER interaction with a p21-activated kinase (PAK6).,2002,10.1210/mend.16.1.0753,https://pubmed.ncbi.nlm.nih.gov/11773441/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAK6,ENSG00000137843,Unsafe,11278661,"Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6.",2001,10.1074/jbc.m010311200,https://pubmed.ncbi.nlm.nih.gov/11278661/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,42510730,Age- and Cell-Specific Regulation of Testicular Polyamine Metabolism Promotes Increased Catabolism During Maturation and Aging in Syrian Hamsters.,2026,10.3390/biology15141184,https://pubmed.ncbi.nlm.nih.gov/42510730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,42567516,Spermine oxidase promotes oxidative stress during islet inflammation.,2026,10.1016/j.jbc.2026.113412,https://pubmed.ncbi.nlm.nih.gov/42567516/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,41355953,Targeted Accumulation of Reactive Acrolein via Nanoparticle-embedded Reverse Temperature Hydrogel for Bladder Cancer Treatment.,2026,10.7150/thno.119307,https://pubmed.ncbi.nlm.nih.gov/41355953/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,42095011,Ornithine decarboxylase influences granulosa cell proliferation and steroidogenesis: implications for ovarian regression in Wuding chickens.,2026,10.3389/fvets.2026.1801162,https://pubmed.ncbi.nlm.nih.gov/42095011/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,38994986,Polyamine Catabolism Revisited: Acetylpolyamine Oxidase Plays a Minor Role due to Low Expression.,2024,10.3390/cells13131134,https://pubmed.ncbi.nlm.nih.gov/38994986/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,38813798,Robotic mechanical wounding is sufficient to induce phenylacetaldoxime accumulation in &lt;i&gt;Tococa quadrialata&lt;/i&gt;.,2024,10.1080/15592324.2024.2360298,https://pubmed.ncbi.nlm.nih.gov/38813798/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,39898884,Poly(2-alkyl-2-oxazoline) Hydrogels as Synthetic Matrices for Multicellular Spheroid and Intestinal Organoid Cultures.,2025,10.1021/acs.biomac.4c01627,https://pubmed.ncbi.nlm.nih.gov/39898884/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,40382136,Quantification of spermine oxidase (SMOX) activity in tissues by HPLC.,2025,10.1016/bs.mie.2025.01.075,https://pubmed.ncbi.nlm.nih.gov/40382136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,37584327,"Biosynthesis, herbivore induction, and defensive role of phenylacetaldoxime glucoside.",2023,10.1093/plphys/kiad448,https://pubmed.ncbi.nlm.nih.gov/37584327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,36142401,Expression of Polyamine Oxidase in Fibroblasts Induces MMP-1 and Decreases the Integrity of Extracellular Matrix.,2022,10.3390/ijms231810487,https://pubmed.ncbi.nlm.nih.gov/36142401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,35886868,Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells.,2022,10.3390/ijms23147521,https://pubmed.ncbi.nlm.nih.gov/35886868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,38882497,Changes in seminal plasma microecological dynamics and the mechanistic impact of core metabolite hexadecanamide in asthenozoospermia patients.,2024,10.1002/imt2.166,https://pubmed.ncbi.nlm.nih.gov/38882497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,40490622,DNA methylation changes in thyroid cancer patients infected with SARS-CoV-2.,2026,10.1007/s13304-025-02233-x,https://pubmed.ncbi.nlm.nih.gov/40490622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,37854191,Identifying potential biomarkers for non-obstructive azoospermia using WGCNA and machine learning algorithms.,2023,10.3389/fendo.2023.1108616,https://pubmed.ncbi.nlm.nih.gov/37854191/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,35178160,Rebalance of the Polyamine Metabolism Suppresses Oxidative Stress and Delays Senescence in Nucleus Pulposus Cells.,2022,10.1155/2022/8033353,https://pubmed.ncbi.nlm.nih.gov/35178160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,40298243,Antibacterial and Cell-Adhesive Poly(2-ethyl-2-oxazoline) Hydrogels Developed for Wound Treatment: &lt;i&gt;In Vitro&lt;/i&gt; Evaluation.,2025,10.1021/acs.biomac.5c00181,https://pubmed.ncbi.nlm.nih.gov/40298243/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,37166515,"Identification and characterization of cytochrome P450 CYP77A59 of loquat (Rhaphiolepis bibas) responsible for biosynthesis of phenylacetonitrile, a floral nitrile compound.",2023,10.1007/s00425-023-04151-x,https://pubmed.ncbi.nlm.nih.gov/37166515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,36300527,Metabolic link between auxin production and specialized metabolites in Sorghum bicolor.,2023,10.1093/jxb/erac421,https://pubmed.ncbi.nlm.nih.gov/36300527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,37759783,Indomethacin Induces Spermidine/Spermine-N1-Acetyltransferase-1 via the Nucleolin-CDK1 Axis and Synergizes with the Polyamine Oxidase Inhibitor Methoctramine in Lung Cancer Cells.,2023,10.3390/biom13091383,https://pubmed.ncbi.nlm.nih.gov/37759783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,34429019,Metabolite analysis of Arabidopsis CYP79A2 overexpression lines reveals turnover of benzyl glucosinolate and an additive effect of different aldoximes on phenylpropanoid repression.,2021,10.1080/15592324.2021.1966586,https://pubmed.ncbi.nlm.nih.gov/34429019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,41143401,Discovery and Optimization of a Novel Series of Pyrazolopyrimidines as Spermine Oxidase Inhibitors.,2025,10.1021/acs.jmedchem.5c01449,https://pubmed.ncbi.nlm.nih.gov/41143401/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,36423492,Amphiphilic nonionic block and gradient copoly(2-oxazoline)s based on 2-methyl-2-oxazoline and 2-phenyl-2-oxazoline as efficient stabilizers for the formulation of tailor-made emulsions.,2023,10.1016/j.jcis.2022.11.018,https://pubmed.ncbi.nlm.nih.gov/36423492/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,36133793,Poly(2-alkyl-2-oxazoline)s: A polymer platform to sustain the release from tablets with a high drug loading.,2022,10.1016/j.mtbio.2022.100414,https://pubmed.ncbi.nlm.nih.gov/36133793/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,35151773,PEDV infection affects the expression of polyamine-related genes inhibiting viral proliferation.,2022,10.1016/j.virusres.2022.198708,https://pubmed.ncbi.nlm.nih.gov/35151773/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,35200446,Design and Synthesis of Hybrid Thermo-Responsive Hydrogels Based on Poly(2-oxazoline) and Gelatin Derivatives.,2022,10.3390/gels8020064,https://pubmed.ncbi.nlm.nih.gov/35200446/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,36368116,Comparative transcriptome analysis in the caput segment of yak and cattleyak epididymis.,2023,10.1016/j.theriogenology.2022.10.039,https://pubmed.ncbi.nlm.nih.gov/36368116/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,33052878,POC1A acts as a promising prognostic biomarker associated with high tumor immune cell infiltration in gastric cancer.,2020,10.18632/aging.103624,https://pubmed.ncbi.nlm.nih.gov/33052878/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,30213554,"Skin irritation and sensitization potential of oxidative hair dye substances evaluated with in vitro, in chemico and in silico test methods.",2018,10.1016/j.fct.2018.09.017,https://pubmed.ncbi.nlm.nih.gov/30213554/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,34522028,The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme.,2022,10.1038/s41417-021-00386-6,https://pubmed.ncbi.nlm.nih.gov/34522028/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,25172862,Biosynthetic pathway for the cyanide-free production of phenylacetonitrile in Escherichia coli by utilizing plant cytochrome P450 79A2 and bacterial aldoxime dehydratase.,2014,10.1128/aem.01623-14,https://pubmed.ncbi.nlm.nih.gov/25172862/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,16600031,"Operational strategies, monitoring and control of heterologous protein production in the methylotrophic yeast Pichia pastoris under different promoters: a review.",2006,10.1186/1475-2859-5-17,https://pubmed.ncbi.nlm.nih.gov/16600031/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAOX,ENSG00000148832,Unsafe,12477380,Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion.,2003,10.1042/bj20021779,https://pubmed.ncbi.nlm.nih.gov/12477380/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,42322030,Sporadic Progressive Ataxia and Palatal Tremor: An Autopsy Case without Tau Pathology.,2026,10.1002/mdc3.70715,https://pubmed.ncbi.nlm.nih.gov/42322030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,41846291,Identification of biomarkers for non-obstructive azoospermia based on microRNA and bioinformatics screening.,2026,10.16288/j.yczz.25-089,https://pubmed.ncbi.nlm.nih.gov/41846291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,40791641,The Role of Drug-Induced Sleep Endoscopy with Positive Airway Pressure Titration in the Individualized Treatment of Obstructive Sleep Apnea: A Report of Three Illustrative Cases.,2025,10.2147/nss.s539613,https://pubmed.ncbi.nlm.nih.gov/40791641/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,38544788,Progressive ataxia and palatal tremor (PAPT) with hypertrophic olivary degeneration (HOD): A case report.,2024,10.1016/j.radcr.2024.01.054,https://pubmed.ncbi.nlm.nih.gov/38544788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,39628899,"Consultative, Proactive Physical Therapy in Early Multiple Sclerosis.",2024,10.7224/1537-2073.2023-058,https://pubmed.ncbi.nlm.nih.gov/39628899/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,33211273,BNC1 Promotes Spermatogenesis by Regulating Transcription of Ybx2 and Papolb via Direct Binding to Their Promotor Elements.,2021,10.1007/s43032-020-00342-z,https://pubmed.ncbi.nlm.nih.gov/33211273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,34746970,High-resolution pediatric age-specific 18F-FDG PET template: a pilot study in epileptogenic focus localization.,2022,10.1007/s00259-021-05611-w,https://pubmed.ncbi.nlm.nih.gov/34746970/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,32760720,"SLIT2 Overexpression in Periodontitis Intensifies Inflammation and Alveolar Bone Loss, Possibly via the Activation of MAPK Pathway.",2020,10.3389/fcell.2020.00593,https://pubmed.ncbi.nlm.nih.gov/32760720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,36464381,Phlebotomy-induced iron deficiency attenuates the pulmonary toxicity of paraquat in mice.,2022,10.1016/j.pestbp.2022.105278,https://pubmed.ncbi.nlm.nih.gov/36464381/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,38636085,Polyvalent Aptamer-Functionalized NIR-II Quantum Dots for Targeted Theranostics in High PD-L1-Expressing Tumors.,2024,10.1021/acsami.4c01486,https://pubmed.ncbi.nlm.nih.gov/38636085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,29109362,PAPOLB/TPAP regulates spermiogenesis independently of chromatoid body-associated factors.,2018,10.1262/jrd.2017-106,https://pubmed.ncbi.nlm.nih.gov/29109362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,30744435,The poly(A) polymerase beta gene may not be associated with azoospermia caused by Sertoli-cell-only syndrome in Japanese patients by comparing patients and normal controls.,2019,10.1080/01443615.2018.1504205,https://pubmed.ncbi.nlm.nih.gov/30744435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,33748112,Downregulation of Macrophage-Specific Act-1 Intensifies Periodontitis and Alveolar Bone Loss Possibly via TNF/NF-κB Signaling.,2021,10.3389/fcell.2021.628139,https://pubmed.ncbi.nlm.nih.gov/33748112/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,27647534,"Adenylation by testis-specific cytoplasmic poly(A) polymerase, PAPOLB/TPAP, is essential for spermatogenesis.",2016,10.1262/jrd.2016-116,https://pubmed.ncbi.nlm.nih.gov/27647534/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,37289398,"Glipizide Alleviates Periodontitis Pathogenicity via Inhibition of Angiogenesis, Osteoclastogenesis and M1/M2 Macrophage Ratio in Periodontal Tissue.",2023,10.1007/s10753-023-01850-1,https://pubmed.ncbi.nlm.nih.gov/37289398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,32606544,A Syndrome of Progressive Ataxia and Palatal Tremor (PAPT) in a Patient with Hypertrophic Olivary Degeneration.,2020,10.4103/aian.aian_170_19,https://pubmed.ncbi.nlm.nih.gov/32606544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,30609807,"MiR-125b-2 Knockout in Testis Is Associated with Targeting to the PAP Gene, Mitochondrial Copy Number, and Impaired Sperm Quality.",2019,10.3390/ijms20010148,https://pubmed.ncbi.nlm.nih.gov/30609807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,33887928,Experimental and theoretical study on p-aminophenylthyil radical geminate recombination in ionic liquids; analysis using the Smoluchowski-Collins-Kimball equation.,2021,10.1063/5.0047663,https://pubmed.ncbi.nlm.nih.gov/33887928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,26339529,Hypermetabolism of Olivary Nuclei in a Patient with Progressive Ataxia and Palatal Tremor.,2015,10.7916/d8pv6jmt,https://pubmed.ncbi.nlm.nih.gov/26339529/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,31508801,Using Implementation Frameworks to Provide Proactive Physical Therapy for People With Parkinson Disease: Case Report.,2019,10.1093/ptj/pzz129,https://pubmed.ncbi.nlm.nih.gov/31508801/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,30712821,"Separation using high-speed counter-current chromatography and identification of 1,3-bis(4-phenylazophenyl)triazene, an impurity in the color additive D&C Red No. 17 (Sudan III).",2019,10.1016/j.chroma.2019.01.072,https://pubmed.ncbi.nlm.nih.gov/30712821/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPOLB,ENSG00000218823,Unsafe,31872045,Near Infrared Boron Dipyrromethene Nanoparticles for Optotheranostics.,2018,10.1002/smtd.201700370,https://pubmed.ncbi.nlm.nih.gov/31872045/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,41892220,Pan-Cancer Analysis of &lt;i&gt;PAPPA&lt;/i&gt; Gene Reveals Tumor-Specific Prognostic Effects.,2026,10.3390/biology15060460,https://pubmed.ncbi.nlm.nih.gov/41892220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,42778146,Novel human neutralizing monoclonal antibodies against Pregnancy-Associated Plasma Protein A for the treatment of Autosomal Dominant Polycystic Kidney Disease.,2026,10.1016/j.kint.2026.08.020,https://pubmed.ncbi.nlm.nih.gov/42778146/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,42650159,miR-27b-3p Exacerbates VCD-Induced KGN Cell Injury by Targeting PAPPA to Suppress IGF-1 Release and Inhibit the PI3K/AKT Pathway.,2026,10.3390/genes17080966,https://pubmed.ncbi.nlm.nih.gov/42650159/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,42464618,Synovial Chondromatosis Harboring a Novel FOS::PAPPA Fusion: Expanding the Phenotypic Spectrum of FOS-Rearranged Neoplasms.,2026,10.1111/pin.70156,https://pubmed.ncbi.nlm.nih.gov/42464618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,42794985,Comparative Gene Expression Analysis of Epithelioid Pleural and Peritoneal Mesothelioma.,2026,10.3390/cancers18183018,https://pubmed.ncbi.nlm.nih.gov/42794985/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,40683301,PAPPA's role in female reproduction.,2025,10.1530/rep-25-0012,https://pubmed.ncbi.nlm.nih.gov/40683301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,42739747,Composition and Function of Decellularized Human Lung Extracellular Matrix from Congenital Pulmonary Airway Malformation.,2026,10.3390/jcm15176742,https://pubmed.ncbi.nlm.nih.gov/42739747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,41972358,High Expression of PAPP-A Predicts Poor Outcomes in Oestrogen Receptor-Positive Breast Cancer Patients.,2026,10.1002/cam4.71815,https://pubmed.ncbi.nlm.nih.gov/41972358/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,39920676,Overexpression of metalloproteinase PAPPA accelerates cancer progression and correlates with immune cell infiltration in gastric cancer: insights from bioinformatics and in vitro investigations.,2025,10.1186/s12935-025-03650-z,https://pubmed.ncbi.nlm.nih.gov/39920676/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,42045397,Gallic acid chemoprevention of oral carcinogenesis is associated with HSD11β2 upregulation and immune remodeling.,2026,10.1038/s41598-026-50700-1,https://pubmed.ncbi.nlm.nih.gov/42045397/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,39716738,Identification of Pappa and Sall3 as Gli3 direct target genes acting downstream of cilia signaling in corticogenesis.,2024,10.1093/cercor/bhae480,https://pubmed.ncbi.nlm.nih.gov/39716738/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,39951875,Circular RNA pappalysin-1 enhances glycolysis via microRNA-656-3p targeting G-protein subunit gamma-5 to promote colon cancer progression.,2025,10.1016/j.clinsp.2025.100594,https://pubmed.ncbi.nlm.nih.gov/39951875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,42176774,Effectiveness and mechanistic effects of green mamba related peptide MQ232 in an orthologous mouse model of autosomal dominant polycystic kidney disease.,2026,10.1016/j.kint.2026.04.021,https://pubmed.ncbi.nlm.nih.gov/42176774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,40318815,CircPAPPA binds to PAPPA and promotes trophoblast proliferation in spontaneous abortion through the formation of circPAPPA-PAPPA complexes.,2025,10.1016/j.gene.2025.149538,https://pubmed.ncbi.nlm.nih.gov/40318815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,41296178,Establishment of immortalized ovarian stromal cell lines using Sendai virus vectors: a platform for studying tumor-stroma interactions and carcinogenesis.,2025,10.1007/s13577-025-01324-6,https://pubmed.ncbi.nlm.nih.gov/41296178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,42020920,ChREBP-mediated regulation of lipid metabolism in liver and brown adipose tissue of long-lived mice.,2026,10.1007/s11357-026-02263-2,https://pubmed.ncbi.nlm.nih.gov/42020920/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,41583513,Molecular Subtyping and Prognostic Prediction in Pancreatic Cancer Based on Mitophagy-Related Genes.,2026,10.7150/ijms.121350,https://pubmed.ncbi.nlm.nih.gov/41583513/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,41901341,From a Multi-Omics Signature to a Therapeutic Candidate: Computational Prediction and Experimental Validation in Liver Fibrosis.,2026,10.3390/ph19030495,https://pubmed.ncbi.nlm.nih.gov/41901341/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,40948775,Novel proteomics biomarkers of recurrent pregnancy loss reflect the dysregulation of immune interactions at the maternal-fetal interface.,2025,10.3389/fimmu.2025.1621168,https://pubmed.ncbi.nlm.nih.gov/40948775/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,42651933,Population-Level Lambing Interval Patterns and Evaluation of Three Previously Reported Candidate SNPs in Hu and Tan Sheep.,2026,10.3390/ani16162527,https://pubmed.ncbi.nlm.nih.gov/42651933/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,42400798,Chimeric RNAs as Novel Neoantigens for Extracellular Vesicles-Based Vaccines Against Cancer.,2026,10.1007/978-1-0716-5202-2_16,https://pubmed.ncbi.nlm.nih.gov/42400798/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,40550318,Pericardiotomy and Amiodarone for Prophylaxis Against Postoperative Atrial Fibrillation in Cardiac Surgery (PAPPA).,2025,10.1016/j.athoracsur.2025.05.045,https://pubmed.ncbi.nlm.nih.gov/40550318/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,39500896,Genomic variations associated with risk and protection against vincristine-induced peripheral neuropathy in pediatric cancer patients.,2024,10.1038/s41525-024-00443-7,https://pubmed.ncbi.nlm.nih.gov/39500896/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,35927827,Neoantigen-based cancer vaccination using chimeric RNA-loaded dendritic cell-derived extracellular vesicles.,2022,10.1002/jev2.12243,https://pubmed.ncbi.nlm.nih.gov/35927827/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,37777759,Integrative evaluation and experimental validation of the immune-modulating potential of dysregulated extracellular matrix genes in high-grade serous ovarian cancer prognosis.,2023,10.1186/s12935-023-03061-y,https://pubmed.ncbi.nlm.nih.gov/37777759/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,40346322,A systematic review of emerging RNA markers in thyroid fine needle aspiration cytology samples: advancements and challenges.,2025,10.1007/s12020-025-04266-z,https://pubmed.ncbi.nlm.nih.gov/40346322/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,39847262,Painful diabetic neuropathy is associated with accelerated epigenetic aging.,2025,10.1007/s11357-025-01516-w,https://pubmed.ncbi.nlm.nih.gov/39847262/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,36300085,"Identification of a dysregulated CircRNA-associated gene signature for predicting prognosis, immune landscape, and drug candidates in bladder cancer.",2022,10.3389/fonc.2022.1018285,https://pubmed.ncbi.nlm.nih.gov/36300085/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,39666139,Downregulation of the NF-κB protein p65 is a shared phenotype among most anti-aging interventions.,2025,10.1007/s11357-024-01466-9,https://pubmed.ncbi.nlm.nih.gov/39666139/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,35205651,Characterisation of the Stromal Microenvironment in Lobular Breast Cancer.,2022,10.3390/cancers14040904,https://pubmed.ncbi.nlm.nih.gov/35205651/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,10491647,Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues.,1999,10.1095/biolreprod61.4.1083,https://pubmed.ncbi.nlm.nih.gov/10491647/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,10077652,The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A.,1999,10.1073/pnas.96.6.3149,https://pubmed.ncbi.nlm.nih.gov/10077652/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,7526035,Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta.,1994,,https://pubmed.ncbi.nlm.nih.gov/7526035/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA,ENSG00000182752,Unsafe,7508748,Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA.,1994,10.1021/bi00172a040,https://pubmed.ncbi.nlm.nih.gov/7508748/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,41993134,&lt;i&gt;PAPPA2&lt;/i&gt; c.392G&gt;C Heterozygous Mutation Associates Primary Open-Angle Glaucoma in a Chinese Family.,2026,10.1155/humu/5591097,https://pubmed.ncbi.nlm.nih.gov/41993134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,42125896,Sex-specific hormonal rescue of bone growth in PAPPA2-deficient mice : a role for cannabinoid receptors and STAT3.,2026,10.1302/2046-3758.155.bjr-2025-0563.r1,https://pubmed.ncbi.nlm.nih.gov/42125896/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,41563143,Comprehensive Analysis of PAPPA2 Expression and Genetic Variants in Sheep and Their Association With Litter Size.,2026,10.1002/vms3.70793,https://pubmed.ncbi.nlm.nih.gov/41563143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,40526299,Genetic deletion of microRNA-15a/16-1 in pericytes stimulates cerebral angiogenesis and promotes functional recovery after ischemic stroke.,2025,10.1007/s10456-025-09987-3,https://pubmed.ncbi.nlm.nih.gov/40526299/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,42157926,Elucidating Tumorigenesis Mechanisms and Assessing Immunotherapeutic Efficacy in Patient-Derived Medulloblastoma Organoid Models.,2026,10.7150/ijbs.116040,https://pubmed.ncbi.nlm.nih.gov/42157926/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,40683301,PAPPA's role in female reproduction.,2025,10.1530/rep-25-0012,https://pubmed.ncbi.nlm.nih.gov/40683301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,40495150,Whole-genome resequencing reveals positive selection and introgression signatures and genetic loci associated with early puberty traits in Chinese indigenous pigs.,2025,10.1186/s12711-025-00975-1,https://pubmed.ncbi.nlm.nih.gov/40495150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,40695421,Alteration of IGF-1 bioavailability due to PAPPA2 deficiency leads to sex-specific metabolic disturbances.,2025,10.1016/j.metabol.2025.156355,https://pubmed.ncbi.nlm.nih.gov/40695421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,41691624,Insulin-like growth factor signaling regulates zebrafish lymphatic-vessel development.,2026,10.1016/j.celrep.2026.116971,https://pubmed.ncbi.nlm.nih.gov/41691624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,41673303,Embigin is involved in the regulation of early mouse kidney development.,2026,10.1038/s41598-026-39966-7,https://pubmed.ncbi.nlm.nih.gov/41673303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,42824949,"Idiopathic short stature in the genomic era: a focused narrative review of genotype-phenotype correlation, selective neuroimaging, IGF-1 biology, and growth hormone responsiveness.",2026,10.1297/cpe.2026-0035,https://pubmed.ncbi.nlm.nih.gov/42824949/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,40327717,DNA hydroxy methylases Tet1 and Tet2 regulate bone aging and bone marrow stromal cell metabolism through the IGF-1/mTOR signaling axis.,2025,10.1093/stmcls/sxaf026,https://pubmed.ncbi.nlm.nih.gov/40327717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,42459939,"&lt;i&gt;Staphylococcus aureus&lt;/i&gt; aggravates psoriasis in human keratinocytes with the assistance of IL-17A and TNF- α, along with a contribution from genes associated with skin cutaneous melanoma.",2026,10.22099/mbrc.2025.54205.2207,https://pubmed.ncbi.nlm.nih.gov/42459939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,42298623,Potentials of BMSCs for regulating osteogenic-vascular-neural-lymphatic coupling in bone regeneration.,2026,10.1186/s12938-026-01594-7,https://pubmed.ncbi.nlm.nih.gov/42298623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,40681537,Raised Leptin and Pappalysin2 cell-free RNAs are the hallmarks of pregnancies complicated by preeclampsia with fetal growth restriction.,2025,10.1038/s41467-025-61931-7,https://pubmed.ncbi.nlm.nih.gov/40681537/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,40875153,DNA methylation and transcription factor-driven immune subtypes in ovarian cancer.,2025,10.1007/s12672-025-02630-z,https://pubmed.ncbi.nlm.nih.gov/40875153/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,38589872,"Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments.",2024,10.1186/s13293-024-00603-5,https://pubmed.ncbi.nlm.nih.gov/38589872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,41629900,Early gestational prediction of spontaneous preterm birth using a validated three-protein serum biomarker panel.,2026,10.1186/s12916-026-04639-9,https://pubmed.ncbi.nlm.nih.gov/41629900/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,40829695,Paracrine IGFBP3 spatially coordinates IGF signaling to induce myocardial regeneration in mice.,2025,10.1016/j.yjmcc.2025.08.004,https://pubmed.ncbi.nlm.nih.gov/40829695/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,39544937,Development and validation of preeclampsia predictive models using key genes from bioinformatics and machine learning approaches.,2024,10.3389/fimmu.2024.1416297,https://pubmed.ncbi.nlm.nih.gov/39544937/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,42027904,Runs of homozygosity reveal candidate genes for economic traits in Danish Large White pigs.,2026,10.5194/aab-69-25-2026,https://pubmed.ncbi.nlm.nih.gov/42027904/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,35811392,PAPPA2 mutation as a novel indicator stratifying beneficiaries of immune checkpoint inhibitors in skin cutaneous melanoma and non-small cell lung cancer.,2022,10.1111/cpr.13283,https://pubmed.ncbi.nlm.nih.gov/35811392/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,40199872,Molecular subtyping of hypertensive disorders of pregnancy.,2025,10.1038/s41467-025-58157-y,https://pubmed.ncbi.nlm.nih.gov/40199872/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,39707003,NMF typing and machine learning algorithm-based exploration of preeclampsia-related mechanisms on ferroptosis signature genes.,2024,10.1007/s10565-024-09963-5,https://pubmed.ncbi.nlm.nih.gov/39707003/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,34680885,PAPPA2 Promote the Proliferation of Dermal Papilla Cells in Hu Sheep (Ovis aries) by Regulating IGFBP5.,2021,10.3390/genes12101490,https://pubmed.ncbi.nlm.nih.gov/34680885/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,37124627,"Unveiling DNA damage repair-based molecular subtypes, tumor microenvironment and pharmacogenomic landscape in gastric cancer.",2023,10.3389/fgene.2023.1118889,https://pubmed.ncbi.nlm.nih.gov/37124627/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,41019979,Integrating genomic mutations and tumor-infiltrating lymphocytes improves prediction of response to trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer.,2025,10.20517/cdr.2025.133,https://pubmed.ncbi.nlm.nih.gov/41019979/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,36345344,"Defining the origin, evolution, and immune composition of SDH-deficient renal cell carcinoma.",2022,10.1016/j.isci.2022.105389,https://pubmed.ncbi.nlm.nih.gov/36345344/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,34222004,"Novel Prognostic Biomarkers in Gastric Cancer: CGB5, MKNK2, and PAPPA2.",2021,10.3389/fonc.2021.683582,https://pubmed.ncbi.nlm.nih.gov/34222004/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,32004755,Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors.,2020,10.1016/j.jcmgh.2020.01.010,https://pubmed.ncbi.nlm.nih.gov/32004755/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,29942928,PAPPA2 as a Therapeutic Modulator of IGF-I Bioavailability: in Vivo and in Vitro Evidence.,2018,10.1210/js.2018-00106,https://pubmed.ncbi.nlm.nih.gov/29942928/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,37962678,Marked intestinal trans-differentiation by autoimmune gastritis along with ectopic pancreatic and pulmonary trans-differentiation.,2024,10.1007/s00535-023-02055-x,https://pubmed.ncbi.nlm.nih.gov/37962678/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,32426899,Glycosylated fibronectin point-of-care test for diagnosis of pre-eclampsia in a low-resource setting: a prospective Southeast Asian population study.,2020,10.1111/1471-0528.16323,https://pubmed.ncbi.nlm.nih.gov/32426899/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,11597188,The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant.,2001,10.1053/plac.2001.0709,https://pubmed.ncbi.nlm.nih.gov/11597188/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PAPPA2,ENSG00000116183,Unsafe,11264294,"Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase.",2001,10.1074/jbc.m102191200,https://pubmed.ncbi.nlm.nih.gov/11264294/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,40780543,Prognostic Significance of Poly (ADP-Ribose) Polymerase 1 Binding Protein Expression and CD8&lt;sup&gt;+&lt;/sup&gt; Tumor-Infiltrating Lymphocytes in Hepatocellular Carcinoma.,2025,10.1016/j.labinv.2025.104226,https://pubmed.ncbi.nlm.nih.gov/40780543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,42467589,PARI deficiency leads to increased somatic hypermutation.,2026,10.1093/jimmun/vkag031,https://pubmed.ncbi.nlm.nih.gov/42467589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,42794600,Peripheral Blood Transcriptomic Profile Associated with Cutaneous Radiation Injury in Cancer Patients Undergoing Radiotherapy.,2026,10.3390/ijms27188168,https://pubmed.ncbi.nlm.nih.gov/42794600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,40783572,"Non-coding genetic elements of lung cancer identified using whole genome sequencing in 13,722 Chinese.",2025,10.1038/s41467-025-62459-6,https://pubmed.ncbi.nlm.nih.gov/40783572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,41171097,Roles of Srs2/PARI-family DNA helicases in NoCut checkpoint signaling and abscission regulation.,2025,10.1083/jcb.202502014,https://pubmed.ncbi.nlm.nih.gov/41171097/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,39982115,The flux of energy in critical illness and the obesity paradox.,2025,10.1152/physrev.00029.2024,https://pubmed.ncbi.nlm.nih.gov/39982115/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,42267146,Morphology and Micromorphological Examination of Giant Subcutaneous Fibrosarcoma in Goats: Five Cases.,2026,10.1155/crve/6704467,https://pubmed.ncbi.nlm.nih.gov/42267146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,42168385,circPARPBP promotes cancer stemness and chemoresistance in triple-negative breast cancer through recruiting SRCAP complex to activate CCL20 transcription.,2026,10.1038/s41388-026-03819-4,https://pubmed.ncbi.nlm.nih.gov/42168385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,42797339,Engineering of OHet72 Nanocrystals into Nanostructured Microparticles for Pulmonary Delivery of a Novel Antitubercular Drug Candidate.,2026,10.3390/pharmaceutics18091164,https://pubmed.ncbi.nlm.nih.gov/42797339/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,40558143,Development of a System to Deliver Inhalational Antibiotics to Marmosets.,2025,10.3390/antibiotics14060554,https://pubmed.ncbi.nlm.nih.gov/40558143/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,39344879,Psychiatric Difficulties in Children with Celiac Disease and the Relationship between Adherence to Treatment and Parental Attitudes.,2024,10.5152/tjg.2024.23493,https://pubmed.ncbi.nlm.nih.gov/39344879/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,35100974,Depletion of C12orf48 inhibits gastric cancer growth and metastasis via up-regulating Poly r(C)-Binding Protein (PCBP) 1.,2022,10.1186/s12885-022-09220-0,https://pubmed.ncbi.nlm.nih.gov/35100974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,30949905,Overexpression of PARPBP Correlates with Tumor Progression and Poor Prognosis in Hepatocellular Carcinoma.,2019,10.1007/s10620-019-05608-4,https://pubmed.ncbi.nlm.nih.gov/30949905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,37963726,"Sleep characteristics and adolescent physical activity-related injuries in sports clubs, leisure time and schools.",2024,10.1136/ip-2023-044936,https://pubmed.ncbi.nlm.nih.gov/37963726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,39093984,Pediatric adapted risk index to predict 2-year transplant-related mortality post-HSCT in children.,2024,10.1182/bloodadvances.2024013484,https://pubmed.ncbi.nlm.nih.gov/39093984/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,41448793,"Design of the MIST study: a double-blind, randomised, placebo-controlled phase 2b trial of pirfenidone solution for inhalation in patients with progressive pulmonary fibrosis.",2025,10.1136/bmjresp-2024-003059,https://pubmed.ncbi.nlm.nih.gov/41448793/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,36056690,SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP.,2022,10.1111/jcmm.17540,https://pubmed.ncbi.nlm.nih.gov/36056690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,40843981,Novel Probiotic Strains From Honey and Fermented Edible Flowers Mitigate Chronic Cortisol-Induced Leaky Gut Syndrome in the CaCo&lt;sub&gt;2&lt;/sub&gt; Cell Model.,2025,10.1111/1750-3841.70464,https://pubmed.ncbi.nlm.nih.gov/40843981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,40800516,"Selective inference for fMRI cluster-wise analysis, issues, and recommendations for critical vector selection: A comment on Blain et al.",2024,10.1162/imag_a_00198,https://pubmed.ncbi.nlm.nih.gov/40800516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,33281951,PARPBP is a prognostic marker and confers anthracycline resistance to breast cancer.,2020,10.1177/1758835920974212,https://pubmed.ncbi.nlm.nih.gov/33281951/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,42895471,Pretransplant immune dysregulation and survival after HSCT in pediatric inborn errors of immunity.,2027,10.70962/jhi.20260093,https://pubmed.ncbi.nlm.nih.gov/42895471/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,41018874,Antibacterial and Antibiofilm Properties of Kulim Bark (&lt;i&gt;Scorodocarpus borneensis&lt;/i&gt; Becc.) Hydrogel on Polymicrobial Biofilms.,2025,10.3831/kpi.2025.28.3.178,https://pubmed.ncbi.nlm.nih.gov/41018874/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,41475328,"Bioremediation of oil-contaminated beach sediments of Pari Islands, Thousands Archipelago, Indonesia: Evaluating microalgal toxicity and bioremediation effectiveness.",2026,10.1016/j.marpolbul.2025.119176,https://pubmed.ncbi.nlm.nih.gov/41475328/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,40335953,"Vaccine hesitancy among parents of children with chronic diseases of different pathophysiology: a cross-sectional study in Sivas, Türkiye.",2025,10.1186/s12889-025-22797-y,https://pubmed.ncbi.nlm.nih.gov/40335953/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,38952723,Construction of PARI public health education programs for Chinese undergraduates: a Delphi study.,2024,10.3389/fpubh.2024.1390011,https://pubmed.ncbi.nlm.nih.gov/38952723/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,38975360,"Knowledge, attitudes, practice, and public health education demand regarding PARI prevention: a cross-sectional study among Chinese undergraduates.",2024,10.3389/fpubh.2024.1387789,https://pubmed.ncbi.nlm.nih.gov/38975360/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,39286058,"Randomised, phase 1/2a trial of ION-827359, an antisense oligonucleotide inhibitor of ENaC.",2024,10.1183/23120541.00986-2023,https://pubmed.ncbi.nlm.nih.gov/39286058/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,38133160,Accuracy of the persistent AKI risk index in predicting acute kidney injury in patients admitted to the intensive care unit for acute respiratory failure.,2023,10.5935/2965-2774.20230141-en,https://pubmed.ncbi.nlm.nih.gov/38133160/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,38782317,Chitosan/bovine serum albumin layer-by-layer assembled particles for non-invasive inhaled drug delivery to the lungs.,2024,10.1016/j.ijbiomac.2024.132526,https://pubmed.ncbi.nlm.nih.gov/38782317/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,35279069,The Procalcitonin-guided Antibiotics in Respiratory Infections (PARI) project in general practice - a study protocol.,2022,10.1186/s12875-022-01646-6,https://pubmed.ncbi.nlm.nih.gov/35279069/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,31112621,"Pharmacokinetics and safety of tobramycin nebulization with the I-neb and PARI-LC Plus in children with cystic fibrosis: A randomized, crossover study.",2019,10.1111/bcp.13988,https://pubmed.ncbi.nlm.nih.gov/31112621/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,35181635,ETV2 regulates PARP-1 binding protein to induce ER stress-mediated death in tuberin-deficient cells.,2022,10.26508/lsa.202201369,https://pubmed.ncbi.nlm.nih.gov/35181635/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,36619972,Identifying biomarkers of differential chemotherapy response in TNBC patient-derived xenografts with a CTD/WGCNA approach.,2023,10.1016/j.isci.2022.105799,https://pubmed.ncbi.nlm.nih.gov/36619972/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PARPBP,ENSG00000185480,Unsafe,20931645,"C12orf48, termed PARP-1 binding protein, enhances poly(ADP-ribose) polymerase-1 (PARP-1) activity and protects pancreatic cancer cells from DNA damage.",2011,10.1002/gcc.20828,https://pubmed.ncbi.nlm.nih.gov/20931645/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,42790834,Therapeutic intervention of PBK/TOPK: Bridging cellular signaling to drug discovery.,2026,10.1016/j.phrs.2026.109643,https://pubmed.ncbi.nlm.nih.gov/42790834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,42516669,Evidence for PDZ-Binding Kinase in Lung Disease With an Emphasis on PAH.,2026,10.1002/pul2.70369,https://pubmed.ncbi.nlm.nih.gov/42516669/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,42855092,PBK drives pulmonary fibrosis via activating p53/ACVR1C/Smad-mediated epithelial-mesenchymal transition.,2026,10.1016/j.ijbiomac.2026.154789,https://pubmed.ncbi.nlm.nih.gov/42855092/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,40301429,"Correlation study of PBK/TOPK expression, prognosis, and immune infiltration in breast cancer.",2025,10.1038/s41598-025-96542-1,https://pubmed.ncbi.nlm.nih.gov/40301429/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,42724446,PDZ-binding kinase promotes ovarian cancer cell proliferation and invasion via &lt;i&gt;CCNB1&lt;/i&gt; regulation.,2026,10.21037/tcr-2026-1337,https://pubmed.ncbi.nlm.nih.gov/42724446/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,42079338,Advances in T-Lymphokine-activated Killer Cell-originated Protein Kinase Research in Cancer Over the Past Thirty Years.,2026,10.15430/jcp.25.055,https://pubmed.ncbi.nlm.nih.gov/42079338/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,42277369,Elevated Plasma T-LAK cell-originated protein kinase Owned the Potential for Predicting Favorable Outcomes in Acute Ischemic Stroke Patients.,2026,10.1007/s10571-026-01765-z,https://pubmed.ncbi.nlm.nih.gov/42277369/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,41868885,TOPK Suppresses the CD8&lt;sup&gt;+&lt;/sup&gt; T Cell Antitumor Immunity via Modulation of IRF5 Expression.,2026,10.34133/cancomm.0021,https://pubmed.ncbi.nlm.nih.gov/41868885/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,40987773,"PBK/TOPK mediates Ikaros, Aiolos and CTCF displacement from mitotic chromosomes and alters chromatin accessibility at selected C2H2-zinc finger protein binding sites.",2025,10.1038/s41467-025-63740-4,https://pubmed.ncbi.nlm.nih.gov/40987773/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,42594715,TCGA-based identification and functional validation of PBK in intrahepatic cholangiocarcinoma progression with involvement of AKT signaling.,2026,10.1016/j.tranon.2026.102977,https://pubmed.ncbi.nlm.nih.gov/42594715/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,41362722,"The Roles of TOPK in Tumorigenesis and Development: Structure, Mechanisms, Pathways, and Therapeutic Implications.",2026,10.7150/ijbs.122960,https://pubmed.ncbi.nlm.nih.gov/41362722/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,42237026,Targeting the TOPK-STAT3 pathway in keratinocytes and mast cells mediates the therapeutic attenuation of Atopic dermatitis.,2026,10.1007/s00011-026-02281-y,https://pubmed.ncbi.nlm.nih.gov/42237026/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,42650106,Dual-Target Inhibition of CDK5 and PBK in Pituitary Neuroendocrine Tumors: Mechanisms and Therapeutic Potential.,2026,10.3390/genes17080909,https://pubmed.ncbi.nlm.nih.gov/42650106/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,42696959,A chemoresistance-associated proliferation gene signature identified by single-cell and machine learning analysis predicts prognosis in high-grade serous ovarian carcinoma.,2026,10.1016/j.tranon.2026.103018,https://pubmed.ncbi.nlm.nih.gov/42696959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,41681955,The Correlation of &lt;i&gt;PBK&lt;/i&gt; Expression with an Immune-Activated Tumor Microenvironment and Outcome in Colorectal Cancer.,2026,10.3390/cancers18030482,https://pubmed.ncbi.nlm.nih.gov/41681955/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,42338660,NAMs for closing knowledge gaps in assessment of respiratory uptake - a PARC project.,2026,10.3389/ftox.2026.1764276,https://pubmed.ncbi.nlm.nih.gov/42338660/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,40697330,Integrated Multi-Omics Profiling Identifies PDZ-Binding Kinase (PBK) as a Novel Prognostic Biomarker in Hepatocellular Carcinoma.,2025,10.2147/jhc.s493907,https://pubmed.ncbi.nlm.nih.gov/40697330/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,42908832,FroHyNet: frozen temporal priors and trainable hypergraph fusion for brain time-series classification.,2026,10.3389/fmed.2026.1966334,https://pubmed.ncbi.nlm.nih.gov/42908832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,41121382,Pbk positively regulates myoblast differentiation and muscle regeneration via enhancing AMPK/ULK1 mediated myogenic autophagy.,2025,10.1186/s12967-025-07173-z,https://pubmed.ncbi.nlm.nih.gov/41121382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,41988986,PBK-Loaded secretory autophagosomes drive radiotherapy-induced systemic adipose depletion via MAPK/ERK-PRKA/PKA-LIPE/HSL signaling: a therapeutic target for esophageal cancer cachexia.,2026,10.1080/15548627.2026.2661313,https://pubmed.ncbi.nlm.nih.gov/41988986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,42915411,Integrating High-Throughput Toxicity Testing with Mechanistic and Kinetic Modeling for Food Chemical Safety Assessment.,2026,10.1021/acs.est.6c00344,https://pubmed.ncbi.nlm.nih.gov/42915411/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,41417572,TOPK Inhibition Promotes Anti-Tumor Immunity Via eIF4F Complex Mediated STAT1 Translation in Gastric Cancer.,2026,10.1002/advs.202517380,https://pubmed.ncbi.nlm.nih.gov/41417572/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,40826334,TOPK promotes immune suppression in kidney renal clear cell carcinoma and emerges as a prognostic and therapeutic target.,2025,10.1186/s12885-025-14665-0,https://pubmed.ncbi.nlm.nih.gov/40826334/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,41793954,A human next generation PBK model for PFOA.,2026,10.1016/j.envint.2026.110161,https://pubmed.ncbi.nlm.nih.gov/41793954/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,41061481,B7-H3-mediated reversal of CAR-T cell exhaustion induces a notable antitumour response in ovarian cancer models.,2025,10.1016/j.ebiom.2025.105949,https://pubmed.ncbi.nlm.nih.gov/41061481/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,42363979,PBK modelling of phthalates and their metabolites and the application in next generation risk assessment.,2026,10.1007/s00204-026-04487-9,https://pubmed.ncbi.nlm.nih.gov/42363979/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,41439007,Scientific Opinion on the application of physiologically based kinetic (PBK) modelling for the quantitative in vitro to in vivo extrapolation (QIVIVE) of developmental neurotoxicity in vitro battery (DNT IVB) data for pesticide active substances.,2025,10.2903/j.efsa.2025.9814,https://pubmed.ncbi.nlm.nih.gov/41439007/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,11378444,PDZ-binding kinase participates in spermatogenesis.,2001,10.1016/s1357-2725(01)00005-x,https://pubmed.ncbi.nlm.nih.gov/11378444/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PBK,ENSG00000168078,Unsafe,10781613,"Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells.",2000,10.1074/jbc.m909629199,https://pubmed.ncbi.nlm.nih.gov/10781613/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,42151386,Overlapping expression and co-operative function of the zebrafish pcdh15 paralogs.,2026,10.1038/s42003-026-10289-7,https://pubmed.ncbi.nlm.nih.gov/42151386/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,41511851,A Novel Intronic Variant Causes Aberrant Splicing of PCDH15 in a Family With Usher Syndrome Type 1F.,2026,10.1002/mgg3.70189,https://pubmed.ncbi.nlm.nih.gov/41511851/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,39441757,PCDH15 dual-AAV gene therapy for deafness and blindness in Usher syndrome type 1F models.,2024,10.1172/jci177700,https://pubmed.ncbi.nlm.nih.gov/39441757/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,42723338,Compound Heterozygous PCDH15 Variants Associated With Cone-Rod Dystrophy in a Chinese Pedigree.,2026,10.1002/mgg3.70298,https://pubmed.ncbi.nlm.nih.gov/42723338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,40802839,Role of Pcdh15 in the development of intrinsic polarity of inner ear hair cells.,2025,10.1371/journal.pgen.1011825,https://pubmed.ncbi.nlm.nih.gov/40802839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,42263124,Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15.,2026,10.1073/pnas.2607573123,https://pubmed.ncbi.nlm.nih.gov/42263124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,40486680,Outcomes of cochlear implants in patients with &lt;i&gt;PCDH15&lt;/i&gt; mutations: a clinical study.,2025,10.3389/fgene.2025.1541333,https://pubmed.ncbi.nlm.nih.gov/40486680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,37864333,Dual AAV-based PCDH15 gene therapy achieves sustained rescue of visual function in a mouse model of Usher syndrome 1F.,2023,10.1016/j.ymthe.2023.10.017,https://pubmed.ncbi.nlm.nih.gov/37864333/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,41548882,"The Impact of Pcdh15 Deficiency on Cellular Energy Metabolism and Oxidative Stress, and Its Role and Mechanism in Hearing Loss.",2026,10.21053/ceo.2025-00263,https://pubmed.ncbi.nlm.nih.gov/41548882/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,41907450,Identification of a recessive &lt;i&gt;PCDH15&lt;/i&gt; nonsense variant in purebred goats with vestibular dysfunction.,2026,10.1016/j.vas.2026.100626,https://pubmed.ncbi.nlm.nih.gov/41907450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,37100771,Mini-PCDH15 gene therapy rescues hearing in a mouse model of Usher syndrome type 1F.,2023,10.1038/s41467-023-38038-y,https://pubmed.ncbi.nlm.nih.gov/37100771/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,37312453,Rescue of hearing by adenine base editing in a humanized mouse model of Usher syndrome type 1F.,2023,10.1016/j.ymthe.2023.06.007,https://pubmed.ncbi.nlm.nih.gov/37312453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,42411868,Genomic Copy Number Variants Associated With Strabismus and Amblyopia in the All of Us Research Program.,2026,10.1167/iovs.67.8.21,https://pubmed.ncbi.nlm.nih.gov/42411868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,41668373,The protocadherin-15-LHFPL5 tip link complex is a heterotetrameric assembly in hair cell stereocilia.,2026,10.1016/j.bpj.2026.02.003,https://pubmed.ncbi.nlm.nih.gov/41668373/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,38806495,"Mice with deficiency in Pcdh15, a gene associated with bipolar disorders, exhibit significantly elevated diurnal amplitudes of locomotion and body temperature.",2024,10.1038/s41398-024-02952-6,https://pubmed.ncbi.nlm.nih.gov/38806495/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,36384460,Case report: novel PCDH15 variant causes usher syndrome type 1F with congenital hearing loss and syndromic retinitis pigmentosa.,2022,10.1186/s12886-022-02659-6,https://pubmed.ncbi.nlm.nih.gov/36384460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,34751129,"Proposed therapy, developed in a &lt;i&gt;Pcdh15&lt;/i&gt;-deficient mouse, for progressive loss of vision in human Usher syndrome.",2021,10.7554/elife.67361,https://pubmed.ncbi.nlm.nih.gov/34751129/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,37595869,Neuronal SAM68 differentially regulates alternative last exon splicing and ensures proper synapse development and function.,2023,10.1016/j.jbc.2023.105168,https://pubmed.ncbi.nlm.nih.gov/37595869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,39187782,A novel compound heterozygous PCDH15 variants is associated with arRP in a Chinese pedigree.,2024,10.1186/s12886-024-03640-1,https://pubmed.ncbi.nlm.nih.gov/39187782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,41187086,LHFPL5 is required for maximal activation of the mechanotransduction channel in cochlear hair cells.,2025,10.1073/pnas.2505627122,https://pubmed.ncbi.nlm.nih.gov/41187086/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,42890602,Integration of blood-based biomarkers and genomic variants identifies individuals with mild cognitive impairment who benefit from multidomain intervention.,2026,10.1002/trc2.70329,https://pubmed.ncbi.nlm.nih.gov/42890602/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,41793414,Sequencing and health data resource of children of African ancestry.,2026,10.1016/j.gim.2025.101660,https://pubmed.ncbi.nlm.nih.gov/41793414/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,40877827,"Inherited retinal diseases in Kentucky: diagnostic yield, gene variants, and novel mutations in a U.S. population.",2025,10.1186/s12920-025-02186-5,https://pubmed.ncbi.nlm.nih.gov/40877827/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,20301442,Usher Syndrome Type I,1993,,https://pubmed.ncbi.nlm.nih.gov/20301442/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,37232061,Case report: Compound heterozygous nonsense PCDH15 variant and a novel deep-intronic variant in a Chinese child with profound hearing loss.,2023,10.1002/mgg3.2193,https://pubmed.ncbi.nlm.nih.gov/37232061/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,38067373,Integrated Genomic Analysis of Primary Prostate Tumor Foci and Corresponding Lymph Node Metastases Identifies Mutations and Pathways Associated with Metastasis.,2023,10.3390/cancers15235671,https://pubmed.ncbi.nlm.nih.gov/38067373/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,39393808,Delivering large genes using adeno-associated virus and the CRE-lox DNA recombination system.,2024,10.1093/hmg/ddae144,https://pubmed.ncbi.nlm.nih.gov/39393808/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,39313156,"Acquired gene alterations in patients treated with ribociclib plus endocrine therapy or endocrine therapy alone using baseline and end-of-treatment circulating tumor DNA samples in the MONALEESA-2, -3, and -7 trials.",2025,10.1016/j.annonc.2024.09.010,https://pubmed.ncbi.nlm.nih.gov/39313156/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,36565421,Genetic advances in Meniere Disease.,2023,10.1007/s11033-022-08149-8,https://pubmed.ncbi.nlm.nih.gov/36565421/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,36740149,Identification of methyltransferase modification genes associated with prognosis and immune features of pancreatic adenocarcinoma.,2023,10.1016/j.mcp.2023.101897,https://pubmed.ncbi.nlm.nih.gov/36740149/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,38028584,"Genetic diversity, population structure, and selective signature of sheep in the northeastern Tarim Basin.",2023,10.3389/fgene.2023.1281601,https://pubmed.ncbi.nlm.nih.gov/38028584/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,39044131,"A large-scale screening identified in USH2A gene the P3272L founder pathogenic variant explaining familial Usher syndrome in Sardinia, Italy.",2024,10.1186/s12886-024-03578-4,https://pubmed.ncbi.nlm.nih.gov/39044131/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,18719945,Gene structure and mutant alleles of PCDH15: nonsyndromic deafness DFNB23 and type 1 Usher syndrome.,2008,10.1007/s00439-008-0543-3,https://pubmed.ncbi.nlm.nih.gov/18719945/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,16369489,Protocadherin 15 (PCDH15): a new secreted isoform and a potential marker for NK/T cell lymphomas.,2006,10.1038/sj.onc.1209301,https://pubmed.ncbi.nlm.nih.gov/16369489/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDH15,ENSG00000150275,Unsafe,11487575,Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F.,2001,10.1093/hmg/10.16.1709,https://pubmed.ncbi.nlm.nih.gov/11487575/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,42794468,Targeted 3.34-Million CpG Site Sequencing Reveals Preliminary Cord Blood Epigenetic Alterations of Autism Spectrum Disorder: A Pilot Study Highlighting the &lt;i&gt;PCDHA1&lt;/i&gt;-&lt;i&gt;PCDHA8&lt;/i&gt; Cluster.,2026,10.3390/ijms27188038,https://pubmed.ncbi.nlm.nih.gov/42794468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,41310996,DNA Methylation Levels at the C3orf37 Loci Correlate With Prostate Cancer Grade.,2026,10.1111/iju.70299,https://pubmed.ncbi.nlm.nih.gov/41310996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,42465740,&lt;i&gt;Blomia tropicalis&lt;/i&gt; allergens induce lung DNA methylation changes in neuroimmune genes in a mouse model of airway inflammation.,2026,10.3389/fimmu.2026.1775662,https://pubmed.ncbi.nlm.nih.gov/42465740/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,42100242,"Multivariate, Multi-Omic Analysis in 799,429 Individuals Identifies 134 Loci Associated with Somatoform Traits.",2026,10.1159/000551114,https://pubmed.ncbi.nlm.nih.gov/42100242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,41458355,Integrating Extracellular Vesicles Proteomics and Clinical Parameters to Develop a High-Precision Predictive Model for Severe Asthma.,2025,10.2147/jir.s556255,https://pubmed.ncbi.nlm.nih.gov/41458355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,41133714,A Pilot Epigenome-Wide Study of Posttraumatic Growth: Identifying Novel Candidates for Future Research.,2025,10.3390/epigenomes9040039,https://pubmed.ncbi.nlm.nih.gov/41133714/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,36858841,PCDHA1 High Expression is Associated With Poor Prognosis and Correlated With Immune Cell Infiltration in Breast Cancer.,2023,10.1016/j.clbc.2023.02.001,https://pubmed.ncbi.nlm.nih.gov/36858841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,39717325,A Rare Case of Polymicrogyria in an Elderly Individual With Unique Polygenic Underlining.,2024,10.7759/cureus.74300,https://pubmed.ncbi.nlm.nih.gov/39717325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,36277156,Novel variants identified in a three‑generation family with concomitant exotropia.,2022,10.3892/etm.2022.11624,https://pubmed.ncbi.nlm.nih.gov/36277156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,36036911,Decreased Levels of DNA Methylation in the PCDHA Gene Cluster as a Risk Factor for Early-Onset High Myopia in Young Children.,2022,10.1167/iovs.63.9.31,https://pubmed.ncbi.nlm.nih.gov/36036911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,36970058,Multiregional Sequencing Analysis Reveals Extensive Genetic Heterogeneity in Gastric Tumors from Latinos.,2022,10.1158/2767-9764.crc-22-0149,https://pubmed.ncbi.nlm.nih.gov/36970058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,34704810,Identification and Prognostic Value Exploration of Cyclophosphamide (Cytoxan)-Centered Chemotherapy Response-Associated Genes in Breast Cancer.,2021,10.1089/dna.2021.0077,https://pubmed.ncbi.nlm.nih.gov/34704810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,34948243,New Candidates for Autism/Intellectual Disability Identified by Whole-Exome Sequencing.,2021,10.3390/ijms222413439,https://pubmed.ncbi.nlm.nih.gov/34948243/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,34173924,Immunogenomic profiling and pathological response results from a clinical trial of docetaxel and carboplatin in triple-negative breast cancer.,2021,10.1007/s10549-021-06307-3,https://pubmed.ncbi.nlm.nih.gov/34173924/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,32296631,Bioinformatics Identified 17 Immune Genes as Prognostic Biomarkers for Breast Cancer: Application Study Based on Artificial Intelligence Algorithms.,2020,10.3389/fonc.2020.00330,https://pubmed.ncbi.nlm.nih.gov/32296631/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,32171843,Targeted gene expression study using TaqMan low density array to gain insights into venous thrombo-embolism (VTE) pathogenesis at high altitude.,2020,10.1016/j.bcmd.2020.102421,https://pubmed.ncbi.nlm.nih.gov/32171843/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,24591352,"Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer.",2014,10.1002/cam4.220,https://pubmed.ncbi.nlm.nih.gov/24591352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,19797050,Total expression and dual gene-regulatory mechanisms maintained in deletions and duplications of the Pcdha cluster.,2009,10.1074/jbc.m109.046938,https://pubmed.ncbi.nlm.nih.gov/19797050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,30126146,Identification of Novel Candidate Markers of Type 2 Diabetes and Obesity in Russia by Exome Sequencing with a Limited Sample Size.,2018,10.3390/genes9080415,https://pubmed.ncbi.nlm.nih.gov/30126146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA1,ENSG00000204970,Unsafe,25032869,FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway.,2014,10.1038/cddis.2014.302,https://pubmed.ncbi.nlm.nih.gov/25032869/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA10,ENSG00000250120,Unsafe,40581983,cfMethylPre: deep transfer learning enhances cancer detection based on circulating cell-free DNA methylation profiling.,2025,10.1093/bib/bbaf303,https://pubmed.ncbi.nlm.nih.gov/40581983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA10,ENSG00000250120,Unsafe,38862462,Comprehensive analysis of genetic risk loci uncovers novel candidate genes and pathways in the comorbidity between depression and Alzheimer's disease.,2024,10.1038/s41398-024-02968-y,https://pubmed.ncbi.nlm.nih.gov/38862462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA10,ENSG00000250120,Unsafe,37986376,Establishment of a 6-signature risk model associated with cellular senescence for predicting the prognosis of breast cancer.,2023,10.1097/md.0000000000035923,https://pubmed.ncbi.nlm.nih.gov/37986376/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA10,ENSG00000250120,Unsafe,37329382,miR-218-5p and miR-320a-5p as Biomarkers for Brain Disorders: Focus on the Major Depressive Disorder and Parkinson's Disease.,2023,10.1007/s12035-023-03391-y,https://pubmed.ncbi.nlm.nih.gov/37329382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA10,ENSG00000250120,Unsafe,36036911,Decreased Levels of DNA Methylation in the PCDHA Gene Cluster as a Risk Factor for Early-Onset High Myopia in Young Children.,2022,10.1167/iovs.63.9.31,https://pubmed.ncbi.nlm.nih.gov/36036911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA2,ENSG00000204969,Unsafe,41995537,Causal evidence linking injury-associated DNA methylation to the risk of developing depression or post-traumatic stress disorder.,2026,10.1097/md.0000000000048310,https://pubmed.ncbi.nlm.nih.gov/41995537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA2,ENSG00000204969,Unsafe,41133714,A Pilot Epigenome-Wide Study of Posttraumatic Growth: Identifying Novel Candidates for Future Research.,2025,10.3390/epigenomes9040039,https://pubmed.ncbi.nlm.nih.gov/41133714/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA2,ENSG00000204969,Unsafe,34859219,Maternal immune activation downregulates schizophrenia genes in the foetal mouse brain.,2021,10.1093/braincomms/fcab275,https://pubmed.ncbi.nlm.nih.gov/34859219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA2,ENSG00000204969,Unsafe,36204642,Comprehensive analysis of a TPX2-related TRHDE-AS1/PKIA ceRNA network involving prognostic signatures in Hepatitis B virus-infected hepatocellular carcinoma.,2022,10.3389/fcimb.2022.1025900,https://pubmed.ncbi.nlm.nih.gov/36204642/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA2,ENSG00000204969,Unsafe,36586126,Construction and evaluation of a prognosis prediction model for thyroid carcinoma based on lipid metabolism-related genes.,2022,,https://pubmed.ncbi.nlm.nih.gov/36586126/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA2,ENSG00000204969,Unsafe,34433909,Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients.,2021,10.1038/s41388-021-01998-w,https://pubmed.ncbi.nlm.nih.gov/34433909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA2,ENSG00000204969,Unsafe,17485552,Gene-expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt lymphoma cell lines and primary tumors.,2007,10.1182/blood-2006-12-064865,https://pubmed.ncbi.nlm.nih.gov/17485552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA4,ENSG00000204967,Unsafe,39842729,Genome-Wide and Rare Variant Association Studies of Amblyopia in the All of Us Research Program.,2025,10.1016/j.ophtha.2025.01.013,https://pubmed.ncbi.nlm.nih.gov/39842729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA4,ENSG00000204967,Unsafe,37329382,miR-218-5p and miR-320a-5p as Biomarkers for Brain Disorders: Focus on the Major Depressive Disorder and Parkinson's Disease.,2023,10.1007/s12035-023-03391-y,https://pubmed.ncbi.nlm.nih.gov/37329382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA4,ENSG00000204967,Unsafe,33630843,Hippocampal transcriptome-wide association study and neurobiological pathway analysis for Alzheimer's disease.,2021,10.1371/journal.pgen.1009363,https://pubmed.ncbi.nlm.nih.gov/33630843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA4,ENSG00000204967,Unsafe,27842508,Global DNA methylation profiling uncovers distinct methylation patterns of protocadherin alpha4 in metastatic and non-metastatic rhabdomyosarcoma.,2016,10.1186/s12885-016-2936-3,https://pubmed.ncbi.nlm.nih.gov/27842508/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA4,ENSG00000204967,Unsafe,25418975,Global methylation silencing of clustered proto-cadherin genes in cervical cancer: serving as diagnostic markers comparable to HPV.,2015,10.1002/cam4.335,https://pubmed.ncbi.nlm.nih.gov/25418975/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA5,ENSG00000204965,Unsafe,34859219,Maternal immune activation downregulates schizophrenia genes in the foetal mouse brain.,2021,10.1093/braincomms/fcab275,https://pubmed.ncbi.nlm.nih.gov/34859219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA5,ENSG00000204965,Unsafe,31710242,Predicting the Lung Squamous Cell Carcinoma Diagnosis and Prognosis Markers by Unique DNA Methylation and Gene Expression Profiles.,2020,10.1089/cmb.2019.0138,https://pubmed.ncbi.nlm.nih.gov/31710242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA6,ENSG00000081842,Unsafe,41517999,Genomic comparisons and the adaptive basis of brain size plasticity and chromosomal instability in the Eurasian common shrew.,2026,10.1093/molbev/msag006,https://pubmed.ncbi.nlm.nih.gov/41517999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA6,ENSG00000081842,Unsafe,42465740,&lt;i&gt;Blomia tropicalis&lt;/i&gt; allergens induce lung DNA methylation changes in neuroimmune genes in a mouse model of airway inflammation.,2026,10.3389/fimmu.2026.1775662,https://pubmed.ncbi.nlm.nih.gov/42465740/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA6,ENSG00000081842,Unsafe,30410030,Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression.,2018,10.1038/s41398-018-0281-9,https://pubmed.ncbi.nlm.nih.gov/30410030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHA6,ENSG00000081842,Unsafe,23029284,Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression.,2012,10.1371/journal.pone.0045863,https://pubmed.ncbi.nlm.nih.gov/23029284/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHAC1,ENSG00000248383,Unsafe,42792926,Genome-Wide Analysis of Alternative Splicing Identifies a Prognostic Signature in ER-Positive Breast Cancer.,2026,10.3390/genes17091032,https://pubmed.ncbi.nlm.nih.gov/42792926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHAC1,ENSG00000248383,Unsafe,40092689,Clinical significance and immune landscape analyses of the coagulation-related gene signatures in gastric cancer.,2025,10.7150/jca.104221,https://pubmed.ncbi.nlm.nih.gov/40092689/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHAC1,ENSG00000248383,Unsafe,27544570,"Maternal cadmium, placental PCDHAC1, and fetal development.",2016,10.1016/j.reprotox.2016.08.011,https://pubmed.ncbi.nlm.nih.gov/27544570/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHAC1,ENSG00000248383,Unsafe,19797050,Total expression and dual gene-regulatory mechanisms maintained in deletions and duplications of the Pcdha cluster.,2009,10.1074/jbc.m109.046938,https://pubmed.ncbi.nlm.nih.gov/19797050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHAC1,ENSG00000248383,Unsafe,22610075,Single-CpG-resolution methylome analysis identifies clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas.,2012,10.1093/carcin/bgs177,https://pubmed.ncbi.nlm.nih.gov/22610075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB2,ENSG00000112852,Unsafe,41126357,Splenomegaly in de novo acute myeloid leukemia is associated with ASXL1 mutations together with a distinct clinical and gene expression profile.,2025,10.1186/s40364-025-00833-8,https://pubmed.ncbi.nlm.nih.gov/41126357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB2,ENSG00000112852,Unsafe,38944914,GRIN3A: A biomarker associated with a cribriform pattern and poor prognosis in prostate cancer.,2024,10.1016/j.neo.2024.101023,https://pubmed.ncbi.nlm.nih.gov/38944914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB2,ENSG00000112852,Unsafe,36672262,Sex-Specific Whole-Transcriptome Analysis in the Cerebral Cortex of FAE Offspring.,2023,10.3390/cells12020328,https://pubmed.ncbi.nlm.nih.gov/36672262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB2,ENSG00000112852,Unsafe,36230503,Molecular Classification of Hepatocellular Carcinoma Using Wnt-Hippo Signaling Pathway-Related Genes.,2022,10.3390/cancers14194580,https://pubmed.ncbi.nlm.nih.gov/36230503/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB2,ENSG00000112852,Unsafe,35565183,A Six-Gene Prognostic and Predictive Radiotherapy-Based Signature for Early and Locally Advanced Stages in Non-Small-Cell Lung Cancer.,2022,10.3390/cancers14092054,https://pubmed.ncbi.nlm.nih.gov/35565183/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB2,ENSG00000112852,Unsafe,34373442,Identification of m6A-Related Biomarkers Associated with Prognosis of Colorectal Cancer.,2021,10.12659/msm.932370,https://pubmed.ncbi.nlm.nih.gov/34373442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB2,ENSG00000112852,Unsafe,34704810,Identification and Prognostic Value Exploration of Cyclophosphamide (Cytoxan)-Centered Chemotherapy Response-Associated Genes in Breast Cancer.,2021,10.1089/dna.2021.0077,https://pubmed.ncbi.nlm.nih.gov/34704810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB2,ENSG00000112852,Unsafe,26035870,Deletion of the App-Runx1 region in mice models human partial monosomy 21.,2015,10.1242/dmm.017814,https://pubmed.ncbi.nlm.nih.gov/26035870/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB2,ENSG00000112852,Unsafe,30581036,Genomic characterization of cervical cancer based on human papillomavirus status.,2019,10.1016/j.ygyno.2018.12.017,https://pubmed.ncbi.nlm.nih.gov/30581036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB2,ENSG00000112852,Unsafe,20581473,Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM).,2010,10.4161/cbt.10.6.12537,https://pubmed.ncbi.nlm.nih.gov/20581473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB5,ENSG00000113209,Unsafe,40763480,"Comprehensive evaluation of the PCDHB family in gastric cancer: Prognostic significance, immune infiltration, and experimental validation of PCDHB5's oncogenic role.",2025,10.1016/j.intimp.2025.115318,https://pubmed.ncbi.nlm.nih.gov/40763480/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB5,ENSG00000113209,Unsafe,39765520,Comparative Whole-Genome Analysis of Production Traits and Genetic Structure in Baiyu and Chuanzhong Black Goats.,2024,10.3390/ani14243616,https://pubmed.ncbi.nlm.nih.gov/39765520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB5,ENSG00000113209,Unsafe,34419445,Weighted genes associated with the progression of retinoblastoma: Evidence from bioinformatic analysis.,2021,10.1016/j.exer.2021.108730,https://pubmed.ncbi.nlm.nih.gov/34419445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB5,ENSG00000113209,Unsafe,36389707,Immunotherapy for bilateral multiple ground glass opacities: An exploratory study for synchronous multiple primary lung cancer.,2022,10.3389/fimmu.2022.1009621,https://pubmed.ncbi.nlm.nih.gov/36389707/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB5,ENSG00000113209,Unsafe,28177890,Long noncoding RNA HOTAIR promotes metastasis of renal cell carcinoma by up-regulating histone H3K27 demethylase JMJD3.,2017,10.18632/oncotarget.15047,https://pubmed.ncbi.nlm.nih.gov/28177890/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB5,ENSG00000113209,Unsafe,28327445,"Nine differentially expressed genes from a post mortem study and their association with suicidal status in a sample of suicide completers, attempters and controls.",2017,10.1016/j.jpsychires.2017.03.009,https://pubmed.ncbi.nlm.nih.gov/28327445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB5,ENSG00000113209,Unsafe,24241531,Influence of differentially expressed genes from suicide post-mortem study on personality traits as endophenotypes on healthy subjects and suicide attempters.,2014,10.1007/s00406-013-0469-1,https://pubmed.ncbi.nlm.nih.gov/24241531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB5,ENSG00000113209,Unsafe,17608962,Gene expression profiling of post-mortem orbitofrontal cortex in violent suicide victims.,2008,10.1017/s1461145707007894,https://pubmed.ncbi.nlm.nih.gov/17608962/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB9,ENSG00000177839,Unsafe,41009596,Transcriptional Consequences of MeCP2 Knockdown and Overexpression in Mouse Primary Cortical Neurons.,2025,10.3390/ijms26189032,https://pubmed.ncbi.nlm.nih.gov/41009596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB9,ENSG00000177839,Unsafe,35390792,Protocadherin B9 Is Associated with Human Esophageal Squamous Cell Carcinoma Progression.,2023,10.1159/000523817,https://pubmed.ncbi.nlm.nih.gov/35390792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB9,ENSG00000177839,Unsafe,35533651,Protocadherin B9 Is Associated with Tumorigenesis and Cancer Progression in Colorectal Cancer.,2022,10.1159/000521566,https://pubmed.ncbi.nlm.nih.gov/35533651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB9,ENSG00000177839,Unsafe,35480311,Association of DNA Methylation Patterns in 7 Novel Genes With Ischemic Stroke in the Northern Chinese Population.,2022,10.3389/fgene.2022.844141,https://pubmed.ncbi.nlm.nih.gov/35480311/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB9,ENSG00000177839,Unsafe,30324761,Protocadherin B9 promotes resistance to bicalutamide and is associated with the survival of prostate cancer patients.,2019,10.1002/pros.23728,https://pubmed.ncbi.nlm.nih.gov/30324761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB9,ENSG00000177839,Unsafe,34692499,Exploring Somatic Alteration Associating With Aggressive Behaviors of Papillary Thyroid Carcinomas by Targeted Sequencing.,2021,10.3389/fonc.2021.722814,https://pubmed.ncbi.nlm.nih.gov/34692499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB9,ENSG00000177839,Unsafe,28671736,Overexpression of PCDHB9 promotes peritoneal metastasis and correlates with poor prognosis in patients with gastric cancer.,2017,10.1002/path.4931,https://pubmed.ncbi.nlm.nih.gov/28671736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB9,ENSG00000177839,Unsafe,31905926,Role of Metastasis-Related Genes in Cisplatin Chemoresistance in Gastric Cancer.,2019,10.3390/ijms21010254,https://pubmed.ncbi.nlm.nih.gov/31905926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB9,ENSG00000177839,Unsafe,30649983,Preliminary functional inquiry of lncRNA ENST00000433673 in embryo implantation using bioinformatics analysis.,2019,10.1080/19396368.2018.1563844,https://pubmed.ncbi.nlm.nih.gov/30649983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB9,ENSG00000177839,Unsafe,30980196,"Molecular carcinogenesis of gastric cancer: Lauren classification, mucin phenotype expression, and cancer stem cells.",2019,10.1007/s10147-019-01443-9,https://pubmed.ncbi.nlm.nih.gov/30980196/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB9,ENSG00000177839,Unsafe,20019881,Microarray analysis of retinal gene expression in Egr-1 knockout mice.,2009,,https://pubmed.ncbi.nlm.nih.gov/20019881/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHB9,ENSG00000177839,Unsafe,15836779,Expression analysis of secreted and cell surface genes of five transformed human cell lines and derivative xenograft tumors.,2005,10.1186/1471-2164-6-55,https://pubmed.ncbi.nlm.nih.gov/15836779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGA4,ENSG00000262576,Unsafe,30536060,Identification of Two Mutations in PCDHGA4 and SLFN14 Genes in an Atrial Septal Defect Family.,2018,10.1007/s11596-018-1974-2,https://pubmed.ncbi.nlm.nih.gov/30536060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGA4,ENSG00000262576,Unsafe,34258755,Characteristics of genetic alterations of peripheral T-cell lymphoma in childhood including identification of novel fusion genes: the Japan Children's Cancer Group (JCCG).,2021,10.1111/bjh.17639,https://pubmed.ncbi.nlm.nih.gov/34258755/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGA4,ENSG00000262576,Unsafe,28127622,Differential methylation of genes in individuals exposed to maternal diabetes in utero.,2017,10.1007/s00125-016-4203-1,https://pubmed.ncbi.nlm.nih.gov/28127622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGA4,ENSG00000262576,Unsafe,26786290,Genome-wide methylation profiling identifies novel methylated genes in neuroblastoma tumors.,2016,10.1080/15592294.2016.1138195,https://pubmed.ncbi.nlm.nih.gov/26786290/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGB1,ENSG00000254221,Unsafe,40343304,DNA methylation in peripheral blood leukocytes in late onset Alzheimer's disease.,2025,10.1177/25424823251341176,https://pubmed.ncbi.nlm.nih.gov/40343304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGB1,ENSG00000254221,Unsafe,37862219,Forebrain excitatory neuron-specific loss of Brpf1 attenuates excitatory synaptic transmission and impairs spatial and fear memory.,2024,10.4103/1673-5374.385307,https://pubmed.ncbi.nlm.nih.gov/37862219/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGB1,ENSG00000254221,Unsafe,41240871,Prenatal organophosphate ester exposure and epigenetic changes at birth: a characterization of the methylome in the ECHO cohort.,2025,10.1016/j.envint.2025.109908,https://pubmed.ncbi.nlm.nih.gov/41240871/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGB1,ENSG00000254221,Unsafe,33220024,Multiomic analysis identifies natural intrapatient temporal variability and changes in response to systemic corticosteroid therapy in chronic rhinosinusitis.,2021,10.1002/iid3.349,https://pubmed.ncbi.nlm.nih.gov/33220024/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGB2,ENSG00000253910,Unsafe,42621174,PCDHGB2 promotes docetaxel resistance in prostate cancer via TR4-mediated activation of the HIF-1α/VEGFA pathway.,2026,10.1007/s10616-026-01051-2,https://pubmed.ncbi.nlm.nih.gov/42621174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGB2,ENSG00000253910,Unsafe,37160609,Knockout mouse models as a resource for the study of rare diseases.,2023,10.1007/s00335-023-09986-z,https://pubmed.ncbi.nlm.nih.gov/37160609/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGB2,ENSG00000253910,Unsafe,35977679,A Genomic Instability-Associated Prognostic Signature for Glioblastoma Patients.,2022,10.1016/j.wneu.2022.08.049,https://pubmed.ncbi.nlm.nih.gov/35977679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCDHGB2,ENSG00000253910,Unsafe,41812824,Exosomal cannabidiol: A promising candidate for targeted oral delivery against breast cancer.,2026,10.1016/j.canlet.2026.218416,https://pubmed.ncbi.nlm.nih.gov/41812824/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,42594811,Pcgf5 controls the exit from totipotency in mouse embryonic stem cells.,2026,10.1016/j.bbrc.2026.154417,https://pubmed.ncbi.nlm.nih.gov/42594811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,40462101,Essential roles of DCAF7/WDR68 in mouse embryonic development.,2025,10.1186/s12967-025-06639-4,https://pubmed.ncbi.nlm.nih.gov/40462101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,38533065,Pcgf5: An important regulatory factor in early embryonic neural induction.,2024,10.1016/j.heliyon.2024.e27634,https://pubmed.ncbi.nlm.nih.gov/38533065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,41473004,TLX1 translocation variants and enhancer hijacking influence clinical outcome in T-cell acute lymphoblastic leukemia.,2025,10.1002/hem3.70281,https://pubmed.ncbi.nlm.nih.gov/41473004/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,35585938,Study on Circulating lncRNA Expression Profile in Patients with Cerebral Infarction.,2022,10.1155/2022/3042105,https://pubmed.ncbi.nlm.nih.gov/35585938/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,41574107,Identification of multiple prognostic biomarker sets for risk stratification in SKCM.,2025,10.3389/fbinf.2025.1624329,https://pubmed.ncbi.nlm.nih.gov/41574107/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,36813848,Identification of Parkinson's disease-associated chromatin regulators.,2023,10.1038/s41598-023-30236-4,https://pubmed.ncbi.nlm.nih.gov/36813848/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,38155839,CIZ1 in Xist seeded assemblies at the inactive X chromosome.,2023,10.3389/fcell.2023.1296600,https://pubmed.ncbi.nlm.nih.gov/38155839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,32130724,Polycomb group RING finger protein 5 influences several developmental signaling pathways during the in vitro differentiation of mouse embryonic stem cells.,2020,10.1111/dgd.12659,https://pubmed.ncbi.nlm.nih.gov/32130724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,38562145,Ehrlichia chaffeensis TRP120 ubiquitinates tumor suppressor APC to modulate Hippo and Wnt signaling.,2024,10.3389/fcell.2024.1327418,https://pubmed.ncbi.nlm.nih.gov/38562145/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,35420081,Transcriptional profiling of the chick retina identifies down-regulation of VIP and UTS2B genes during early lens-induced myopia.,2022,10.1039/d1mo00407g,https://pubmed.ncbi.nlm.nih.gov/35420081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,30953002,AUTS2 isoforms control neuronal differentiation.,2021,10.1038/s41380-019-0409-1,https://pubmed.ncbi.nlm.nih.gov/30953002/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,29765032,PCGF5 is required for neural differentiation of embryonic stem cells.,2018,10.1038/s41467-018-03781-0,https://pubmed.ncbi.nlm.nih.gov/29765032/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,29358333,Ehrlichia chaffeensis TRP120 Effector Targets and Recruits Host Polycomb Group Proteins for Degradation To Promote Intracellular Infection.,2018,10.1128/iai.00845-17,https://pubmed.ncbi.nlm.nih.gov/29358333/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,32868440,The genetic basis for PRC1 complex diversity emerged early in animal evolution.,2020,10.1073/pnas.2005136117,https://pubmed.ncbi.nlm.nih.gov/32868440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,30521381,Evidence for functional interactions between the placenta and brain in pregnant mice.,2019,10.1096/fj.201802037r,https://pubmed.ncbi.nlm.nih.gov/30521381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,27136092,Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells.,2016,10.1371/journal.pone.0154561,https://pubmed.ncbi.nlm.nih.gov/27136092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,34451426,Alpha Enolase 1 Ubiquitination and Degradation Mediated by Ehrlichia chaffeensis TRP120 Disrupts Glycolytic Flux and Promotes Infection.,2021,10.3390/pathogens10080962,https://pubmed.ncbi.nlm.nih.gov/34451426/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,31840896,Screening for reproductive biomarkers in Bactrian camel via iTRAQ analysis of proteomes.,2020,10.1111/rda.13607,https://pubmed.ncbi.nlm.nih.gov/31840896/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,28630068,Ehrlichia chaffeensis TRP120 Moonlights as a HECT E3 Ligase Involved in Self- and Host Ubiquitination To Influence Protein Interactions and Stability for Intracellular Survival.,2017,10.1128/iai.00290-17,https://pubmed.ncbi.nlm.nih.gov/28630068/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,30308041,NKL homeobox gene activities in B-cell development and lymphomas.,2018,10.1371/journal.pone.0205537,https://pubmed.ncbi.nlm.nih.gov/30308041/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,30560907,SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells.,2018,10.1038/s41467-018-07787-6,https://pubmed.ncbi.nlm.nih.gov/30560907/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,21859857,"Ehrlichia chaffeensis TRP120 interacts with a diverse array of eukaryotic proteins involved in transcription, signaling, and cytoskeleton organization.",2011,10.1128/iai.05608-11,https://pubmed.ncbi.nlm.nih.gov/21859857/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,27322685,Deregulation of polycomb repressor complex 1 modifier AUTS2 in T-cell leukemia.,2016,10.18632/oncotarget.9982,https://pubmed.ncbi.nlm.nih.gov/27322685/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,19273555,"An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation, and vesicle trafficking.",2009,10.1128/iai.00027-09,https://pubmed.ncbi.nlm.nih.gov/19273555/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,25047847,Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival.,2014,10.1128/iai.01984-14,https://pubmed.ncbi.nlm.nih.gov/25047847/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,23523425,Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs.,2013,10.1016/j.str.2013.02.013,https://pubmed.ncbi.nlm.nih.gov/23523425/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCGF5,ENSG00000180628,Unsafe,23533592,OstemiR: a novel panel of microRNA biomarkers in osteoblastic and osteocytic differentiation from mesencymal stem cells.,2013,10.1371/journal.pone.0058796,https://pubmed.ncbi.nlm.nih.gov/23533592/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,42640160,Generation of a New Immunodeficient Rat Model of Retinal Degeneration With LSL TdTomato Reporter and TdTomato-Pcp2 Expression.,2026,10.1167/tvst.15.8.24,https://pubmed.ncbi.nlm.nih.gov/42640160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,41639119,Polygonatum cyrtonema Hua fructan ameliorates ulcerative colitis via gut microbiota modulation and follistatin targeting.,2026,10.1038/s41538-026-00729-3,https://pubmed.ncbi.nlm.nih.gov/41639119/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,41422503,Repeat-associated non-AUG translation as a common mechanism for the polyGln ataxias.,2026,10.1016/j.celrep.2025.116741,https://pubmed.ncbi.nlm.nih.gov/41422503/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,41365504,[18F]AlF-NOTA-PCP2 PET/CT to Assess PD-L1 Status in Head and Neck Cancer: Head-to-Head Comparison With [18F]FDG PET/CT.,2026,10.1097/rlu.0000000000006151,https://pubmed.ncbi.nlm.nih.gov/41365504/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,40523777,"Deletion of Endocannabinoid Synthesizing Enzyme DAGLα in Pcp2-Positive Cerebellar Purkinje Cells Decreases Depolarization-Induced Short-Term Synaptic Plasticity, Reduces Social Preference, and Heightens Anxiety.",2025,10.1523/eneuro.0400-24.2025,https://pubmed.ncbi.nlm.nih.gov/40523777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,40276214,Deficiency of autism susceptibility gene Trio in cerebellar Purkinje cells leads to delayed motor impairments.,2024,10.3389/fpsyt.2024.1396716,https://pubmed.ncbi.nlm.nih.gov/40276214/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,42290675,Loss of SARM1 Improves Phenotypes in a Mouse Model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay.,2026,10.1212/nxg.0000000000200400,https://pubmed.ncbi.nlm.nih.gov/42290675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,42557105,A Streamlined Workflow for Purkinje Cell Labeling and High-Resolution Analyses of Dendrites and Spines in Mice.,2026,10.1523/eneuro.0455-25.2026,https://pubmed.ncbi.nlm.nih.gov/42557105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,40177067,Peptide-based immuno-PET/CT monitoring of dynamic PD-L1 expression during glioblastoma radiotherapy.,2025,10.1016/j.jpha.2024.101082,https://pubmed.ncbi.nlm.nih.gov/40177067/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,40594855,Identification of spastic ataxia-related proteins via comparative proteomic analysis of the cerebellum of conditional Ankfy1 knockout mice.,2025,10.1038/s41598-025-06398-8,https://pubmed.ncbi.nlm.nih.gov/40594855/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,40557328,Subtle changes in Purkinje cell firing in Purkinje cell-specific &lt;i&gt;Dyt1 ΔGAG&lt;/i&gt; knock-in mice.,2025,10.3389/dyst.2025.14148,https://pubmed.ncbi.nlm.nih.gov/40557328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,42700876,Chronic ethanol exposure alters the expression of genes associated with GPCR-related signaling in the olfactory bulb of male mice.,2026,10.1016/j.alcohol.2026.09.003,https://pubmed.ncbi.nlm.nih.gov/42700876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,39521780,PIGK defects induce apoptosis in Purkinje cells and acceleration of neuroectodermal differentiation.,2024,10.1038/s41419-024-07201-8,https://pubmed.ncbi.nlm.nih.gov/39521780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,38713298,[&lt;sup&gt;18&lt;/sup&gt;F]AlF-NOTA-PCP2: a novel PET/CT tracer for enhanced PD-L1 heterogeneity imaging and comparative analysis with [&lt;sup&gt;18&lt;/sup&gt;F]AlF-NOTA-WL12 in glioblastoma xenografts.,2024,10.1007/s00259-024-06743-5,https://pubmed.ncbi.nlm.nih.gov/38713298/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,39817951,Peptide-based PET/CT imaging visualizes PD-L1-driven radioresistance in glioblastoma.,2025,10.1016/j.drup.2025.101202,https://pubmed.ncbi.nlm.nih.gov/39817951/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,37688710,Ucp4 Knockdown of Cerebellar Purkinje Cells Induces Bradykinesia.,2024,10.1007/s12035-023-03607-1,https://pubmed.ncbi.nlm.nih.gov/37688710/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,41842889,Ablation of cerebellar Purkinje cells enhances seizure susceptibility and promotes kindling.,2026,10.1002/epi.70177,https://pubmed.ncbi.nlm.nih.gov/41842889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,41330895,Understanding interspecies drug response variations between human and rodent P2X7 receptors.,2025,10.1038/s41467-025-65847-0,https://pubmed.ncbi.nlm.nih.gov/41330895/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,35733029,Cholecystokinin Activation of Cholecystokinin 1 Receptors: a Purkinje Cell Neuroprotective Pathway.,2023,10.1007/s12311-022-01428-x,https://pubmed.ncbi.nlm.nih.gov/35733029/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,38948311,Transcriptome Analysis of the Striatum of Electroacupuncture-treated Naïve and Ischemic Stroke Mice.,2024,10.3831/kpi.2024.27.2.162,https://pubmed.ncbi.nlm.nih.gov/38948311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,41280850,Binary Polymeric System Based on Fish Collagen and Poloxamer 407: Mechanical and Rheological Analysis for Pharmaceutical and Biomedical Applications.,2025,10.1021/acsomega.5c04058,https://pubmed.ncbi.nlm.nih.gov/41280850/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,34644575,Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice.,2021,10.1016/j.celrep.2021.109831,https://pubmed.ncbi.nlm.nih.gov/34644575/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,37321386,Cell-specific Dyt1 ∆GAG knock-in to basal ganglia and cerebellum reveal differential effects on motor behavior and sensorimotor network function.,2023,10.1016/j.expneurol.2023.114471,https://pubmed.ncbi.nlm.nih.gov/37321386/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,34548529,"Antioxidant system response, mineral element uptake and safe utilization of Polygonatum sibiricum in cadmium-contaminated soil.",2021,10.1038/s41598-021-97998-7,https://pubmed.ncbi.nlm.nih.gov/34548529/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,37097752,Multiancestry sex-stratified genomic associations with HIV viral load and controller status from the ICGH.,2023,10.1172/jci.insight.170068,https://pubmed.ncbi.nlm.nih.gov/37097752/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,34399854,Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates.,2021,10.1186/s40478-021-01237-z,https://pubmed.ncbi.nlm.nih.gov/34399854/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,32848620,Purkinje Cell-Specific Knockout of Tyrosine Hydroxylase Impairs Cognitive Behaviors.,2020,10.3389/fncel.2020.00228,https://pubmed.ncbi.nlm.nih.gov/32848620/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,33531684,"Human MiniPromoters for ocular-rAAV expression in ON bipolar, cone, corneal, endothelial, Müller glial, and PAX6 cells.",2021,10.1038/s41434-021-00227-z,https://pubmed.ncbi.nlm.nih.gov/33531684/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,32664575,Cerebellar Morphology and Behavioral Profiles in Mice Lacking Heparan Sulfate Ndst Gene Function.,2020,10.3390/jdb8030013,https://pubmed.ncbi.nlm.nih.gov/32664575/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCP2,ENSG00000174788,Unsafe,31244610,MEA6 Deficiency Impairs Cerebellar Development and Motor Performance by Tethering Protein Trafficking.,2019,10.3389/fncel.2019.00250,https://pubmed.ncbi.nlm.nih.gov/31244610/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCSK4,ENSG00000115257,Unsafe,41952686,Novel transcriptomic alterations in poorly differentiated endometrial carcinomas: evidence from South African women.,2026,10.3389/fonc.2026.1694662,https://pubmed.ncbi.nlm.nih.gov/41952686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCSK4,ENSG00000115257,Unsafe,39678461,A comprehensive study of common and rare genetic variants in spermatogenesis-related loci identifies new risk factors for idiopathic severe spermatogenic failure.,2024,10.1093/hropen/hoae069,https://pubmed.ncbi.nlm.nih.gov/39678461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCSK4,ENSG00000115257,Unsafe,37151112,Integrated testis transcriptome and whole genome analysis of sexual maturity in Large White and Tongcheng pigs.,2023,10.1111/rda.14373,https://pubmed.ncbi.nlm.nih.gov/37151112/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCSK4,ENSG00000115257,Unsafe,36188622,Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease.,2022,10.3389/fphar.2022.988561,https://pubmed.ncbi.nlm.nih.gov/36188622/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCSK4,ENSG00000115257,Unsafe,31294140,Human spermatozoa anti-proprotein convertase subtilisin/kexin type 4 synthesis using New Zealand rabbit for novel immunocontraception in males.,2019,10.4111/icu.2019.60.4.303,https://pubmed.ncbi.nlm.nih.gov/31294140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCSK4,ENSG00000115257,Unsafe,34970268,Development and Clinical Validation of Novel 8-Gene Prognostic Signature Associated With the Proportion of Regulatory T Cells by Weighted Gene Co-Expression Network Analysis in Uterine Corpus Endometrial Carcinoma.,2021,10.3389/fimmu.2021.788431,https://pubmed.ncbi.nlm.nih.gov/34970268/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCSK4,ENSG00000115257,Unsafe,29897468,Imbalanced Expression of IGF2 and PCSK4 Is Associated With Overproduction of Big IGF2 in SFT With NICTH: A Pilot Study.,2018,10.1210/jc.2018-00593,https://pubmed.ncbi.nlm.nih.gov/29897468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCSK4,ENSG00000115257,Unsafe,31418107,Duplications in 19p13.3 are associated with male infertility.,2019,10.1007/s10815-019-01547-1,https://pubmed.ncbi.nlm.nih.gov/31418107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCSK4,ENSG00000115257,Unsafe,22357636,Alteration in the processing of the ACRBP/sp32 protein and sperm head/acrosome malformations in proprotein convertase 4 (PCSK4) null mice.,2012,10.1093/molehr/gas009,https://pubmed.ncbi.nlm.nih.gov/22357636/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCSK4,ENSG00000115257,Unsafe,24396277,Genetics of the first seven proprotein convertase enzymes in health and disease.,2013,10.2174/1389202911314050010,https://pubmed.ncbi.nlm.nih.gov/24396277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCSK4,ENSG00000115257,Unsafe,24330629,Relative expression of proprotein convertases in rat ovaries during pregnancy.,2013,10.1186/1757-2215-6-91,https://pubmed.ncbi.nlm.nih.gov/24330629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCSK4,ENSG00000115257,Unsafe,30306731,Identification of a six-gene signature with prognostic value for patients with endometrial carcinoma.,2018,10.1002/cam4.1806,https://pubmed.ncbi.nlm.nih.gov/30306731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCSK4,ENSG00000115257,Unsafe,19109312,Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review.,2009,10.1093/humupd/dmn060,https://pubmed.ncbi.nlm.nih.gov/19109312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCSK4,ENSG00000115257,Unsafe,16371590,"Sperm from mice genetically deficient for the PCSK4 proteinase exhibit accelerated capacitation, precocious acrosome reaction, reduced binding to egg zona pellucida, and impaired fertilizing ability.",2006,10.1095/biolreprod.105.046821,https://pubmed.ncbi.nlm.nih.gov/16371590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCSK4,ENSG00000115257,Unsafe,23065687,Dysregulation of FURIN by prostaglandin-endoperoxide synthase 2 in lung epithelial NCI-H292 cells.,2014,10.1002/mc.21963,https://pubmed.ncbi.nlm.nih.gov/23065687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCSK4,ENSG00000115257,Unsafe,9192653,Impaired fertility in mice deficient for the testicular germ-cell protease PC4.,1997,10.1073/pnas.94.13.6842,https://pubmed.ncbi.nlm.nih.gov/9192653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCSK4,ENSG00000115257,Unsafe,16052608,Synthetic bacterial lipopeptide analogs facilitate naive CD4+ T cell differentiation and enhance antigen-specific HLA-II-restricted responses.,2005,10.1002/eji.200526241,https://pubmed.ncbi.nlm.nih.gov/16052608/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCSK4,ENSG00000115257,Unsafe,16040806,Role of pro-IGF-II processing by proprotein convertase 4 in human placental development.,2005,10.1073/pnas.0502357102,https://pubmed.ncbi.nlm.nih.gov/16040806/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,41780492,The mechanism by which methylase METTL3 affects intramuscular fat deposition.,2026,10.1016/j.psj.2026.106670,https://pubmed.ncbi.nlm.nih.gov/41780492/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,41619017,DAPL1 is activated by Np63 and GRα and regulates lipid metabolism.,2026,10.1007/s00109-025-02636-8,https://pubmed.ncbi.nlm.nih.gov/41619017/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,42023663,PCYT1A Hypophosphorylation Underlies Retinal Lipid Dysregulation in CERKL Retinitis Pigmentosa and Is Therapeutically Reversed by Phosphatidylcholine.,2026,10.1167/iovs.67.4.54,https://pubmed.ncbi.nlm.nih.gov/42023663/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,42400359,A pcyt-1 allelic series reveals in vivo consequences of reduced phosphatidylcholine synthesis in C. elegans.,2026,10.1093/g3journal/jkag161,https://pubmed.ncbi.nlm.nih.gov/42400359/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,41853922,Moderate maternal nutrient restriction alters type II alveolar epithelial cell density in the non-human primate fetal lung.,2026,10.1113/ep093319,https://pubmed.ncbi.nlm.nih.gov/41853922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,41043762,Study on the molecular mechanism of KPNA2 regulation of myocardial ischemia/delayed reperfusion injury through mitophagy.,2025,10.1016/j.cellsig.2025.112157,https://pubmed.ncbi.nlm.nih.gov/41043762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,38858683,PCYT1A deficiency disturbs fatty acid metabolism and induces ferroptosis in the mouse retina.,2024,10.1186/s12915-024-01932-y,https://pubmed.ncbi.nlm.nih.gov/38858683/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,42264740,Involvement of the Xbp1/SREBP-mediated lipid biosynthesis pathway in enhanced phosphine tolerance induced by gut Escherichia coli in Tribolium castaneum.,2026,10.1016/j.pestbp.2026.107137,https://pubmed.ncbi.nlm.nih.gov/42264740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,41672388,Integrated metabolomics and machine learning identify potential biomarkers and metabolism-related targets for MASLD in older adults.,2026,10.1016/j.exger.2026.113067,https://pubmed.ncbi.nlm.nih.gov/41672388/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,42760943,Amniotic-fluid metabolomics identifies phospholipid remodeling as a metabolic signature of intrauterine exposure in pregnancies with polycystic ovary syndrome.,2026,10.3389/fendo.2026.1904695,https://pubmed.ncbi.nlm.nih.gov/42760943/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,42045659,Maternal high-fat high-energy diet impairs surfactant maturation in the non-human primate fetal lung.,2026,10.1038/s41366-026-02090-7,https://pubmed.ncbi.nlm.nih.gov/42045659/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,39472682,Alteration of the metabolite interconversion enzyme in sperm and Sertoli cell of non-obstructive azoospermia: a microarray data and in-silico analysis.,2024,10.1038/s41598-024-77875-9,https://pubmed.ncbi.nlm.nih.gov/39472682/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,39044583,[Functions and mechanisms of testicular descent in Apodemus agrarius based on transcriptomics and metabolomics].,2024,10.13345/j.cjb.240025,https://pubmed.ncbi.nlm.nih.gov/39044583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,40397574,Glycerophospholipid metabolism licenses IgE-mediated mast cell degranulation.,2025,10.1016/j.celrep.2025.115742,https://pubmed.ncbi.nlm.nih.gov/40397574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,40917018,Enzalutamide-Resistant STEAP4&lt;sup&gt;+&lt;/sup&gt; MyoCAF Secrete Phosphatidylcholine to Foster Progression by Activating Stemness in Hormone-Sensitive Prostate Cancer.,2025,10.1002/advs.202510602,https://pubmed.ncbi.nlm.nih.gov/40917018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,40649814,Proteomic Characterization of Human Peripheral Blood Mononuclear Cells Exposed to a 50 Hz Magnetic Field.,2025,10.3390/ijms26136035,https://pubmed.ncbi.nlm.nih.gov/40649814/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,40930294,Metabolomics reveals glycerophospholipid metabolism as the action mechanism of Jin-Tian-Ge capsules in ameliorating inflammatory pain.,2026,10.1016/j.jep.2025.120589,https://pubmed.ncbi.nlm.nih.gov/40930294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,41547451,β-Hydroxybutyrate in subclinical ketosis promotes endoplasmic reticulum biogenesis and milk protein synthesis via IRE1α-XBP1 in bovine mammary epithelial cells.,2026,10.3168/jds.2025-27182,https://pubmed.ncbi.nlm.nih.gov/41547451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,36553621,PCYT1A Missense Variant in Vizslas with Disproportionate Dwarfism.,2022,10.3390/genes13122354,https://pubmed.ncbi.nlm.nih.gov/36553621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,33454021,Genetic diseases of the Kennedy pathways for membrane synthesis.,2020,10.1074/jbc.rev120.013529,https://pubmed.ncbi.nlm.nih.gov/33454021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,34504059,NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation.,2021,10.1038/s41419-021-04127-3,https://pubmed.ncbi.nlm.nih.gov/34504059/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,34234346,Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine.,2021,10.1038/s41586-021-03692-z,https://pubmed.ncbi.nlm.nih.gov/34234346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,36353940,"Size, number and phospholipid composition of milk fat globules are affected by dietary conjugated linoleic acid.",2023,10.1111/jpn.13788,https://pubmed.ncbi.nlm.nih.gov/36353940/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,31467589,Metabolomics combined with network pharmacology exploration reveals the modulatory properties of Astragali Radix extract in the treatment of liver fibrosis.,2019,10.1186/s13020-019-0251-z,https://pubmed.ncbi.nlm.nih.gov/31467589/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,32005242,Choline supplementation prevents diet induced gut mucosa lipid accumulation in post-smolt Atlantic salmon (Salmo salar L.).,2020,10.1186/s12917-020-2252-7,https://pubmed.ncbi.nlm.nih.gov/32005242/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,30681159,Choline-related-inherited metabolic diseases-A mini review.,2019,10.1002/jimd.12011,https://pubmed.ncbi.nlm.nih.gov/30681159/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PCYT1A,ENSG00000161217,Unsafe,10480912,Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant.,1999,10.1074/jbc.274.38.26992,https://pubmed.ncbi.nlm.nih.gov/10480912/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,42761548,Molecular characterization of normal and physiologically suppressed human parathyroid glands at single-cell resolution.,2026,10.1210/jendso/bvag133,https://pubmed.ncbi.nlm.nih.gov/42761548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,41179677,PDE10A as a novel diagnostic and therapeutic target in cancer: insights and challenges.,2025,10.3389/fonc.2025.1669157,https://pubmed.ncbi.nlm.nih.gov/41179677/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,41835457,PDE1B and PDE10A as novel targets for schizophrenia: from molecular design and synthesis to therapeutic promise.,2025,10.3389/fphar.2025.1735760,https://pubmed.ncbi.nlm.nih.gov/41835457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,41590850,Family-Wide Dysregulation of Phosphodiesterases Alters cAMP/cGMP Microdomains in Thoracic Aortic Aneurysm.,2026,10.3390/jcdd13010023,https://pubmed.ncbi.nlm.nih.gov/41590850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,41868793,CAMK1D as a potential therapeutic target for gut microbiota-driven promotion of lung adenocarcinoma development.,2026,10.7717/peerj.20985,https://pubmed.ncbi.nlm.nih.gov/41868793/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,42723497,Temporal Mapping of CSVD-Related White Matter Lesions and Concurrent Neurovascular Dysfunction in Spontaneously Hypertensive Rats.,2026,10.1002/cns.71142,https://pubmed.ncbi.nlm.nih.gov/42723497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,42308131,Smooth Muscle Cell-Specific Expression of Cyclic Nucleotide Phosphodiesterase 10a Promotes the Development of Medial Artery Calcification.,2026,10.1681/asn.0000001164,https://pubmed.ncbi.nlm.nih.gov/42308131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,40568906,Inhibition of Phosphodiesterase 10A by MP-10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome.,2025,10.1002/advs.202500623,https://pubmed.ncbi.nlm.nih.gov/40568906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,40429643,PDE10A Inhibition Reduces NLRP3 Activation and Pyroptosis in Sepsis and Nerve Injury.,2025,10.3390/ijms26104498,https://pubmed.ncbi.nlm.nih.gov/40429643/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,40492975,Early-Onset Movement Disorder Syndrome Caused by Biallelic Variants in PDE1B Encoding Phosphodiesterase 1B.,2025,10.1002/mds.30249,https://pubmed.ncbi.nlm.nih.gov/40492975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,42533223,"PDE10A Inhibition in Schizophrenia: A Randomised, Placebo-Controlled Phase 2 Study of Alofropodect (CPL'36) in Patients Experiencing Acute Schizophrenia.",2026,10.1007/s40263-026-01317-5,https://pubmed.ncbi.nlm.nih.gov/42533223/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,41570039,Integrative multi-omics analyses identify key genes and elucidate bidirectional regulatory mechanisms in thyroid dysfunction.,2026,10.1371/journal.pone.0338805,https://pubmed.ncbi.nlm.nih.gov/41570039/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,41155624,The Emerging Role of Phosphodiesterase Inhibitors in Fragile X Syndrome and Autism Spectrum Disorder.,2025,10.3390/ph18101507,https://pubmed.ncbi.nlm.nih.gov/41155624/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,40943492,Molecular Imbalances Between Striosome and Matrix Compartments Characterize the Pathogenesis and Pathophysiology of Huntington's Disease Model Mouse.,2025,10.3390/ijms26178573,https://pubmed.ncbi.nlm.nih.gov/40943492/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,42866651,Genomic structural variations distinguishing archaic and modern humans are associated with neurodevelopment.,2026,10.1016/j.isci.2026.117741,https://pubmed.ncbi.nlm.nih.gov/42866651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,41146234,Dual PDE4/10A inhibition restores CREB1 function and enhances neuronal resilience in models of alzheimer's disease.,2025,10.1186/s13195-025-01869-6,https://pubmed.ncbi.nlm.nih.gov/41146234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,39358334,Alterations of striatal phosphodiesterase 10 A and their association with recurrence rate in bipolar I disorder.,2024,10.1038/s41398-024-03107-3,https://pubmed.ncbi.nlm.nih.gov/39358334/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,41269079,Structure-Based Optimization of Imidazopyridine Derivatives as Selective and Orally Bioavailable Phosphodiesterase 10A Inhibitors with Reduced Blood-Brain Barrier Penetration for the Treatment of Idiopathic Pulmonary Fibrosis.,2025,10.1021/acs.jmedchem.5c02293,https://pubmed.ncbi.nlm.nih.gov/41269079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,41742140,Single-nucleus atlas provides insights into changes in the evolution of the pig hippocampus.,2026,10.1186/s12915-026-02560-4,https://pubmed.ncbi.nlm.nih.gov/41742140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,38589034,Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype.,2024,10.1101/gad.351350.123,https://pubmed.ncbi.nlm.nih.gov/38589034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,42284637,Integrated network pharmacology and UHPLC-Q-TOF LC-MS/MS phytochemical profiling demonstrate tilianin-mediated restoration of PDE10A/cAMP/PKA/CREB signaling in an MK-801-induced schizophrenia-like model.,2026,10.1016/j.phymed.2026.158394,https://pubmed.ncbi.nlm.nih.gov/42284637/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,41724750,Phase 2b Trial of the PDE10A Inhibitor MK-8189 in People With an Acute Episode of Schizophrenia.,2026,10.1097/jcp.0000000000002152,https://pubmed.ncbi.nlm.nih.gov/41724750/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,40158470,N6-methyladenosine-modified RNF220 induces cisplatin resistance and immune escape via regulating PDE10A K48-linked ubiquitination in bladder cancer.,2025,10.1016/j.bcp.2025.116903,https://pubmed.ncbi.nlm.nih.gov/40158470/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,39056811,A Novel PDE10A Inhibitor for Tourette Syndrome and Other Movement Disorders.,2024,10.3390/cells13141230,https://pubmed.ncbi.nlm.nih.gov/39056811/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,41110127,Development of Selective and Soluble Mitochondrial Complex 1 Inhibitors Derived from Papaverine for Radiosensitization of Cancer.,2025,10.1021/acs.jmedchem.5c02014,https://pubmed.ncbi.nlm.nih.gov/41110127/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,39391487,"Structural insight into the lead identification of a dual inhibitor of PDE1B and PDE10A: Integrating pharmacophore-based virtual screening, molecular docking, and structure-activity-relationship approaches.",2024,10.1016/j.heliyon.2024.e38305,https://pubmed.ncbi.nlm.nih.gov/39391487/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,39708293,"Autoimmune brainstem encephalitis: Clinical associations, outcomes, and proposed diagnostic criteria.",2025,10.1002/acn3.52273,https://pubmed.ncbi.nlm.nih.gov/39708293/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,36454774,Evaluation of the acute oral toxicity and antipsychotic activity of a dual inhibitor of PDE1B and PDE10A in rat model of schizophrenia.,2022,10.1371/journal.pone.0278216,https://pubmed.ncbi.nlm.nih.gov/36454774/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,38617664,Identification of Novel Quinolone and Quinazoline Alkaloids as Phosphodiesterase 10A Inhibitors for Parkinson's Disease through a Computational Approach.,2024,10.1021/acsomega.3c10351,https://pubmed.ncbi.nlm.nih.gov/38617664/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,38851166,Effects of PDE10A inhibitor MK-8189 in people with an acute episode of schizophrenia: A randomized proof-of-concept clinical trial.,2024,10.1016/j.schres.2024.05.019,https://pubmed.ncbi.nlm.nih.gov/38851166/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,27058447,De Novo Mutations in PDE10A Cause Childhood-Onset Chorea with Bilateral Striatal Lesions.,2016,10.1016/j.ajhg.2016.02.015,https://pubmed.ncbi.nlm.nih.gov/27058447/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE10A,ENSG00000112541,Unsafe,10373451,Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A).,1999,10.1074/jbc.274.26.18438,https://pubmed.ncbi.nlm.nih.gov/10373451/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,42761548,Molecular characterization of normal and physiologically suppressed human parathyroid glands at single-cell resolution.,2026,10.1210/jendso/bvag133,https://pubmed.ncbi.nlm.nih.gov/42761548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,41694449,Preventing Cushing Syndrome: Adrenalectomy in &lt;i&gt;PDE11A&lt;/i&gt;-Positive Primary Pigmented Nodular Adrenocortical Disease.,2026,10.1210/jcemcr/luaf329,https://pubmed.ncbi.nlm.nih.gov/41694449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,41816209,cAMP/PKA signaling in endocrine hypertension: genetic mechanisms and pathophysiological insights.,2026,10.3389/fendo.2026.1748702,https://pubmed.ncbi.nlm.nih.gov/41816209/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,39774659,PDE11A Is a Phenotype Modulator of Primary Bilateral Macronodular Adrenal Hyperplasia: Results of a 334-Patient Series.,2025,10.1210/clinem/dgae918,https://pubmed.ncbi.nlm.nih.gov/39774659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,40558524,Age-Related Increases in PDE11A4 Protein Expression Trigger Liquid-Liquid Phase Separation (LLPS) of the Enzyme That Can Be Reversed by PDE11A4 Small Molecule Inhibitors.,2025,10.3390/cells14120897,https://pubmed.ncbi.nlm.nih.gov/40558524/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,42220841,Primary Pigmented Nodular Adrenocortical Disease Presenting as Osteonecrosis of the Femoral Head: A Case Report.,2026,10.7759/cureus.108027,https://pubmed.ncbi.nlm.nih.gov/42220841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,42103875,Ensemble machine learning algorithms leveraged on serum proteomics for enhanced early detection of ovarian cancer.,2026,10.1038/s41598-026-51553-4,https://pubmed.ncbi.nlm.nih.gov/42103875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,40169544,Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors.,2025,10.1038/s41467-025-57896-2,https://pubmed.ncbi.nlm.nih.gov/40169544/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,38132157,The Sleep Quality- and Myopia-Linked PDE11A-Y727C Variant Impacts Neural Physiology by Reducing Catalytic Activity and Altering Subcellular Compartmentalization of the Enzyme.,2023,10.3390/cells12242839,https://pubmed.ncbi.nlm.nih.gov/38132157/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,35929507,Functional characteristics and research trends of PDE11A in human diseases (Review).,2022,10.3892/mmr.2022.12814,https://pubmed.ncbi.nlm.nih.gov/35929507/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,41992590,"Genetic Association of Sexual Behavior, Sildenafil, and Hormonal Contraceptives With Mental Disorders.",2026,10.1002/cns.70861,https://pubmed.ncbi.nlm.nih.gov/41992590/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,40435996,Seminoma Caused by PDE11A Frameshift Variant with Multiple Abnormalities: A Case Report.,2026,10.1159/000546283,https://pubmed.ncbi.nlm.nih.gov/40435996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,35874504,"Phosphodiesterase 11 A (PDE11A), a potential biomarker for glioblastoma.",2022,10.1007/s43188-022-00129-1,https://pubmed.ncbi.nlm.nih.gov/35874504/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,38915195,Whole Exome Sequencing Revealed Paternal Inheritance of Obesity-related Genetic Variants in a Family with an Exclusively Breastfed Infant,2024,10.4274/jcrpe.galenos.2024.2024-1-7,https://pubmed.ncbi.nlm.nih.gov/38915195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,33127481,A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional but reduced Pde11a: Phenotype and impact on adrenocortical function.,2021,10.1016/j.mce.2020.111071,https://pubmed.ncbi.nlm.nih.gov/33127481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,33835157,Exome sequencing revealed PDE11A as a novel candidate gene for early-onset Alzheimer's disease.,2021,10.1093/hmg/ddab090,https://pubmed.ncbi.nlm.nih.gov/33835157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,38473152,"Screening of Litter-Size-Associated SNPs in NOX4, PDE11A and GHR Genes of Sheep.",2024,10.3390/ani14050767,https://pubmed.ncbi.nlm.nih.gov/38473152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,36313756,The cAMP-signaling cancers: Clinically-divergent disorders with a common central pathway.,2022,10.3389/fendo.2022.1024423,https://pubmed.ncbi.nlm.nih.gov/36313756/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,33661511,PDE11A gene polymorphism in testicular cancer: sperm parameters and hormonal profile.,2021,10.1007/s40618-021-01534-3,https://pubmed.ncbi.nlm.nih.gov/33661511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,38549670,Identification of key genes increasing susceptibility to atrial fibrillation in nonalcoholic fatty liver disease and the potential mechanisms: mitochondrial dysfunction and systemic inflammation.,2024,10.3389/fphar.2024.1360974,https://pubmed.ncbi.nlm.nih.gov/38549670/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,34321593,A genetic basis for friendship? Homophily for membrane-associated PDE11A-cAMP-CREB signaling in CA1 of hippocampus dictates mutual social preference in male and female mice.,2021,10.1038/s41380-021-01237-4,https://pubmed.ncbi.nlm.nih.gov/34321593/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,37572526,Biologic that disrupts PDE11A4 homodimerization in hippocampus CA1 reverses age-related cognitive decline of social memories in mice.,2023,10.1016/j.neurobiolaging.2023.07.008,https://pubmed.ncbi.nlm.nih.gov/37572526/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,34887755,The Role of PDE11A4 in Social Isolation-Induced Changes in Intracellular Signaling and Neuroinflammation.,2021,10.3389/fphar.2021.749628,https://pubmed.ncbi.nlm.nih.gov/34887755/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,31303492,Loss of Function of Phosphodiesterase 11A4 Shows that Recent and Remote Long-Term Memories Can Be Uncoupled.,2019,10.1016/j.cub.2019.06.018,https://pubmed.ncbi.nlm.nih.gov/31303492/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,25159071,Does phosphodiesterase 11A (PDE11A) hold promise as a future therapeutic target?,2015,10.2174/1381612820666140826114941,https://pubmed.ncbi.nlm.nih.gov/25159071/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,27339393,"Phosphodiesterase 11A (PDE11A), Enriched in Ventral Hippocampus Neurons, is Required for Consolidation of Social but not Nonsocial Memories in Mice.",2016,10.1038/npp.2016.106,https://pubmed.ncbi.nlm.nih.gov/27339393/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,27646265,PDE11A negatively regulates lithium responsivity.,2017,10.1038/mp.2016.155,https://pubmed.ncbi.nlm.nih.gov/27646265/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,35625779,Genetic Alterations in Benign Adrenal Tumors.,2022,10.3390/biomedicines10051041,https://pubmed.ncbi.nlm.nih.gov/35625779/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,27544407,PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain.,2016,10.1016/j.neuroscience.2016.08.019,https://pubmed.ncbi.nlm.nih.gov/27544407/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,27625633,Alterations of Phosphodiesterases in Adrenocortical Tumors.,2016,10.3389/fendo.2016.00111,https://pubmed.ncbi.nlm.nih.gov/27625633/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,33536912,Evaluation of Serum/Urine Genomic and Metabolomic Profiles to Improve the Adherence to Sildenafil Therapy in Patients with Erectile Dysfunction.,2020,10.3389/fphar.2020.602369,https://pubmed.ncbi.nlm.nih.gov/33536912/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,26459559,Rare inactivating PDE11A variants associated with testicular germ cell tumors.,2015,10.1530/erc-15-0034,https://pubmed.ncbi.nlm.nih.gov/26459559/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,33776926,Molecular Genetic and Genomic Alterations in Cushing's Syndrome and Primary Aldosteronism.,2021,10.3389/fendo.2021.632543,https://pubmed.ncbi.nlm.nih.gov/33776926/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,32397904,PNPT1 and PCGF3 variants associated with angiotensin-converting enzyme inhibitor-induced cough: a nested case-control genome-wide study.,2020,10.2217/pgs-2019-0167,https://pubmed.ncbi.nlm.nih.gov/32397904/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,32507359,Adrenocortical tumorigenesis: Lessons from genetics.,2020,10.1016/j.beem.2020.101428,https://pubmed.ncbi.nlm.nih.gov/32507359/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,16767104,A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia.,2006,10.1038/ng1809,https://pubmed.ncbi.nlm.nih.gov/16767104/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,16079899,Phosphodiesterase 11 (PDE11): is it a player in human testicular function?,2005,10.1038/sj.ijir.3901377,https://pubmed.ncbi.nlm.nih.gov/16079899/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,15800651,"3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues.",2005,10.1038/sj.ijir.3901317,https://pubmed.ncbi.nlm.nih.gov/15800651/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,11121118,Genomic organization of the human phosphodiesterase PDE11A gene. Evolutionary relatedness with other PDEs containing GAF domains.,2001,10.1046/j.1432-1327.2001.01866.x,https://pubmed.ncbi.nlm.nih.gov/11121118/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE11A,ENSG00000128655,Unsafe,10725373,Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A.,2000,10.1073/pnas.97.7.3702,https://pubmed.ncbi.nlm.nih.gov/10725373/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,42826681,Cyclic nucleotide signaling through phosphodiesterase 1 inhibition and its interaction with the competing endogenous RNA network regulates cognition.,2026,10.1016/j.biopha.2026.119963,https://pubmed.ncbi.nlm.nih.gov/42826681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,41799512,Clinical and Functional Characterization of PDE1A as a Wnt/&lt;b&gt;β&lt;/b&gt;-Catenin-Linked Biomarker of Progression and Platinum Resistance in Epithelial Ovarian Cancer.,2026,10.32604/or.2025.072105,https://pubmed.ncbi.nlm.nih.gov/41799512/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,41961843,Network pharmacology and integrative bioinformatics analyses identify PDE1A as a key target of pirfenidone in idiopathic pulmonary fibrosis.,2026,10.1371/journal.pone.0342991,https://pubmed.ncbi.nlm.nih.gov/41961843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,40704992,Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer.,2025,10.7554/elife.98903,https://pubmed.ncbi.nlm.nih.gov/40704992/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,40702743,Transcranial iTBS Combined With Trans-Spinal iTBS Targeting PDE1A/cAMP/PKA Axis Regulates Neural Regeneration After Spinal Cord Injury.,2025,10.1111/cns.70525,https://pubmed.ncbi.nlm.nih.gov/40702743/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,41318996,Phosphodiesterase 1A overexpression contributes to the progression of renal fibrosis.,2026,10.1016/j.ymthe.2025.11.030,https://pubmed.ncbi.nlm.nih.gov/41318996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,41590850,Family-Wide Dysregulation of Phosphodiesterases Alters cAMP/cGMP Microdomains in Thoracic Aortic Aneurysm.,2026,10.3390/jcdd13010023,https://pubmed.ncbi.nlm.nih.gov/41590850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,42661344,Genetic overlap between estimated glomerular filtration rate and cardiovascular disease identifies potential targets for cardiorenal syndrome.,2026,10.1080/0886022x.2026.2721242,https://pubmed.ncbi.nlm.nih.gov/42661344/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,42077463,The cAMP signaling pathway mediates photoperiod-induced follicle development in striped hamsters (&lt;i&gt;Cricetulus barabensis&lt;/i&gt;) supported by association analyses.,2026,10.3389/fendo.2026.1794734,https://pubmed.ncbi.nlm.nih.gov/42077463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,42066062,Citraconate preserves T cell stemness and antitumor immunity.,2026,10.1126/sciimmunol.adz0348,https://pubmed.ncbi.nlm.nih.gov/42066062/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,41227367,The Molecular Mechanism of PDE1 Regulation.,2025,10.3390/cells14211722,https://pubmed.ncbi.nlm.nih.gov/41227367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,41273928,Cyclic nucleotide phosphodiesterase 1 and cognitive impairment: Mechanistic insights and therapeutic implications.,2025,10.1016/j.biopha.2025.118796,https://pubmed.ncbi.nlm.nih.gov/41273928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,39428482,Mapping the glial transcriptome in Huntington's disease using snRNAseq: selective disruption of glial signatures across brain regions.,2024,10.1186/s40478-024-01871-3,https://pubmed.ncbi.nlm.nih.gov/39428482/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,41646192,Mechanism of Yiqi Huoxue Granule in promoting angiogenesis of skin lesion tissue by increasing CSF2 to reduce mesenchymal stem cell apoptosis.,2026,10.3389/fphar.2026.1649017,https://pubmed.ncbi.nlm.nih.gov/41646192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,41561239,Integrating the Data From Microbiome and Metabolome Genome-Wide Association Studies to Uncover Gene-Microbe-Metabolite Interactions in Allergic Diseases.,2025,10.7759/cureus.99600,https://pubmed.ncbi.nlm.nih.gov/41561239/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,35063792,"Secondhand smoke affects reproductive functions by altering the mouse testis transcriptome, and leads to select intron retention in Pde1a.",2022,10.1016/j.envint.2022.107086,https://pubmed.ncbi.nlm.nih.gov/35063792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,40729813,Transcriptome analysis of chicken fibroblast following transforming growth factor β1-mediated activation.,2025,10.1016/j.psj.2025.105576,https://pubmed.ncbi.nlm.nih.gov/40729813/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,39524622,Development of a Candidate &lt;sup&gt;11&lt;/sup&gt;C‑Labeled Selective Phosphodiesterase 1 Radioligand for Positron Emission Tomography.,2024,10.1021/acsomega.4c03214,https://pubmed.ncbi.nlm.nih.gov/39524622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,37063851,Single-cell RNA and transcriptome sequencing profiles identify immune-associated key genes in the development of diabetic kidney disease.,2023,10.3389/fimmu.2023.1030198,https://pubmed.ncbi.nlm.nih.gov/37063851/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,39604216,Cross-pathway integration of cAMP signals through cGMP and calcium-regulated phosphodiesterases in mouse striatal cholinergic interneurons.,2025,10.1111/bph.17400,https://pubmed.ncbi.nlm.nih.gov/39604216/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,37727374,"Transcriptome profiling of intact bowel wall reveals that PDE1A and SEMA3D are possible markers with roles in enteric smooth muscle apoptosis, proliferative disorders, and dysautonomia in Crohn's disease.",2023,10.3389/fgene.2023.1194882,https://pubmed.ncbi.nlm.nih.gov/37727374/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,38179743,"Metabolism-Related Prognostic Biomarkers, Purine Metabolism and Anti-Tumor Immunity in Colon Adenocarcinoma.",2023,10.31083/j.fbl2812328,https://pubmed.ncbi.nlm.nih.gov/38179743/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,37759281,Mesenchymal stem cell-derived extracellular vesicles prevent the formation of pulmonary arterial hypertension through a microRNA-200b-dependent mechanism.,2023,10.1186/s12931-023-02474-7,https://pubmed.ncbi.nlm.nih.gov/37759281/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,38703760,Gut-brain bidirectional determination in regulating the residual feed intake of small-sized meat ducks.,2024,10.1016/j.psj.2024.103778,https://pubmed.ncbi.nlm.nih.gov/38703760/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,37887031,Dysregulated Cyclic Nucleotide Metabolism in Alcohol-Associated Steatohepatitis: Implications for Novel Targeted Therapies.,2023,10.3390/biology12101321,https://pubmed.ncbi.nlm.nih.gov/37887031/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,36531729,Construction of a diagnostic signature and immune landscape of pulmonary arterial hypertension.,2022,10.3389/fcvm.2022.940894,https://pubmed.ncbi.nlm.nih.gov/36531729/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,28904388,Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells.,2017,10.1038/s41598-017-11664-5,https://pubmed.ncbi.nlm.nih.gov/28904388/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,36235159,Effects of Extracts and Flavonoids from Drosera rotundifolia L. on Ciliary Beat Frequency and Murine Airway Smooth Muscle.,2022,10.3390/molecules27196622,https://pubmed.ncbi.nlm.nih.gov/36235159/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,35821031,Whole-genome sequence analysis reveals selection signatures for important economic traits in Xiang pigs.,2022,10.1038/s41598-022-14686-w,https://pubmed.ncbi.nlm.nih.gov/35821031/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,33895190,Role of phosphodiesterase 1 in the pathophysiology of diseases and potential therapeutic opportunities.,2021,10.1016/j.pharmthera.2021.107858,https://pubmed.ncbi.nlm.nih.gov/33895190/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,24700876,Phosphodiesterase 1A modulates cystogenesis in zebrafish.,2014,10.1681/asn.2013040421,https://pubmed.ncbi.nlm.nih.gov/24700876/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,26374610,Modulation of Polycystic Kidney Disease Severity by Phosphodiesterase 1 and 3 Subfamilies.,2016,10.1681/asn.2015010057,https://pubmed.ncbi.nlm.nih.gov/26374610/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,31131329,PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy.,2019,10.1126/sciadv.aaw5870,https://pubmed.ncbi.nlm.nih.gov/31131329/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDE1A,ENSG00000115252,Unsafe,27342643,"Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats.",2016,10.1007/s00213-016-4346-2,https://pubmed.ncbi.nlm.nih.gov/27342643/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,40783453,Disruption of TEX38 impairs sperm morphogenesis and the migration of sperm into the oviduct.,2025,10.1038/s42003-025-08644-1,https://pubmed.ncbi.nlm.nih.gov/40783453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,40820219,Exploring the common genetic basis of metabolic syndrome-related diseases and chronic kidney disease: insights from extensive genome-wide cross-trait analyses.,2025,10.1186/s13040-025-00472-7,https://pubmed.ncbi.nlm.nih.gov/40820219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,39087751,Epididymal mRNA expression profiles for the protein disulfide isomerase gene family: Modulation by development and androgens.,2024,10.1111/andr.13700,https://pubmed.ncbi.nlm.nih.gov/39087751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,39698369,UMOD Genotype and Determinants of Urinary Uromodulin in African Populations.,2024,10.1016/j.ekir.2024.09.015,https://pubmed.ncbi.nlm.nih.gov/39698369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,35228297,Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin.,2022,10.1681/asn.2021040491,https://pubmed.ncbi.nlm.nih.gov/35228297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,35967117,Phenome-Wide Association Study of UMOD Gene Variants and Differential Associations With Clinical Outcomes Across Populations in the Million Veteran Program a Multiethnic Biobank.,2022,10.1016/j.ekir.2022.05.011,https://pubmed.ncbi.nlm.nih.gov/35967117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,37261792,Genome-Wide Association Study of CKD Progression.,2023,10.1681/asn.0000000000000170,https://pubmed.ncbi.nlm.nih.gov/37261792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,36271454,Nidogen-1 could play a role in diabetic kidney disease development in type 2 diabetes: a genome-wide association meta-analysis.,2022,10.1186/s40246-022-00422-y,https://pubmed.ncbi.nlm.nih.gov/36271454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,35471551,PRSS37 deficiency leads to impaired energy metabolism in testis and sperm revealed by DIA-based quantitative proteomic analysis.,2023,10.1007/s43032-022-00918-x,https://pubmed.ncbi.nlm.nih.gov/35471551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,35741705,Genetic Variants Involved in the Crystallization Pathway Are Associated with Calcium Nephrolithiasis in the Chinese Han Population.,2022,10.3390/genes13060943,https://pubmed.ncbi.nlm.nih.gov/35741705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,29203529,Crystal and solution structures of human protein-disulfide isomerase-like protein of the testis (PDILT) provide insight into its chaperone activity.,2018,10.1074/jbc.m117.797290,https://pubmed.ncbi.nlm.nih.gov/29203529/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,26830021,Proteome-wide survey of the autoimmune target repertoire in autoimmune polyendocrine syndrome type 1.,2016,10.1038/srep20104,https://pubmed.ncbi.nlm.nih.gov/26830021/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,24662985,Structure of the substrate-binding b' domain of the Protein Disulfide Isomerase-Like protein of the Testis.,2014,10.1038/srep04464,https://pubmed.ncbi.nlm.nih.gov/24662985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,22357757,Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility [corrected].,2012,10.1073/pnas.1117963109,https://pubmed.ncbi.nlm.nih.gov/22357757/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,25808494,"Expression, sorting, and segregation of Golgi proteins during germ cell differentiation in the testis.",2015,10.1091/mbc.e14-12-1632,https://pubmed.ncbi.nlm.nih.gov/25808494/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,22621904,Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa.,2012,10.1091/mbc.e11-12-1025,https://pubmed.ncbi.nlm.nih.gov/22621904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,17507649,A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells.,2007,10.1091/mbc.e07-02-0147,https://pubmed.ncbi.nlm.nih.gov/17507649/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,33137338,Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline.,2021,10.1016/j.kint.2020.09.030,https://pubmed.ncbi.nlm.nih.gov/33137338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,15475357,"PDILT, a divergent testis-specific protein disulfide isomerase with a non-classical SXXC motif that engages in disulfide-dependent interactions in the endoplasmic reticulum.",2005,10.1074/jbc.m408651200,https://pubmed.ncbi.nlm.nih.gov/15475357/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDILT,ENSG00000169340,Unsafe,24578125,Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis.,2014,10.1681/asn.2013070781,https://pubmed.ncbi.nlm.nih.gov/24578125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,42502479,Downregulation of FTO aggravates osteoarthritis with obesity by erasing m&lt;sup&gt;6&lt;/sup&gt;A methylation of PDP2.,2026,10.1016/j.mmr.2026.100054,https://pubmed.ncbi.nlm.nih.gov/42502479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,40491447,Emerging roles of pyruvate dehydrogenase phosphatase 1: a key player in metabolic health.,2025,10.3389/fphys.2025.1596636,https://pubmed.ncbi.nlm.nih.gov/40491447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,40711448,RNA-binding protein AUF1 suppresses cellular senescence and glycolysis by targeting &lt;i&gt;PDP2&lt;/i&gt; and &lt;i&gt;PGAM1&lt;/i&gt; mRNAs.,2025,10.18632/aging.206286,https://pubmed.ncbi.nlm.nih.gov/40711448/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,41619504,Erianin induces ferroptosis in ovarian cancer cells by upregulating PDP2 and activating the JNK signaling pathway.,2026,10.1016/j.bbrc.2026.153353,https://pubmed.ncbi.nlm.nih.gov/41619504/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,38466744,Autocrine phosphatase PDP2 inhibits ferroptosis by dephosphorylating ACSL4 in the Luminal A Breast Cancer.,2024,10.1371/journal.pone.0299571,https://pubmed.ncbi.nlm.nih.gov/38466744/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,39086481,Characterization of latently infected EBV+ antibody-secreting B cells isolated from ovarian tumors and malignant ascites.,2024,10.3389/fimmu.2024.1379175,https://pubmed.ncbi.nlm.nih.gov/39086481/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,38834972,"Effect of supplementing lysins and methionine to low-protein diets on growth performance, hepatic antioxidant capacity, immune status, and glycolytic activity of tibetan sheep.",2024,10.1186/s12864-024-10480-2,https://pubmed.ncbi.nlm.nih.gov/38834972/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,35692804,Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer.,2022,10.3389/fonc.2022.873516,https://pubmed.ncbi.nlm.nih.gov/35692804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,37601754,Transcriptome profiling of A549 non-small cell lung cancer cells in response to Trichinella spiralis muscle larvae excretory/secretory products.,2023,10.3389/fvets.2023.1208538,https://pubmed.ncbi.nlm.nih.gov/37601754/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,30150402,Pyruvate dehydrogenase phosphatase catalytic subunit 2 limits Th17 differentiation.,2018,10.1073/pnas.1805717115,https://pubmed.ncbi.nlm.nih.gov/30150402/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,31314546,Increased pyruvate dehydrogenase activity in skeletal muscle of growth-restricted ovine fetuses.,2019,10.1152/ajpregu.00106.2019,https://pubmed.ncbi.nlm.nih.gov/31314546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,32650009,"Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors.",2020,10.1016/j.pharmthera.2020.107622,https://pubmed.ncbi.nlm.nih.gov/32650009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,30881593,Adaptations in Protein Expression and Regulated Activity of Pyruvate Dehydrogenase Multienzyme Complex in Human Systolic Heart Failure.,2019,10.1155/2019/4532592,https://pubmed.ncbi.nlm.nih.gov/30881593/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,30876937,Genetic characterization and ex-vivo neutralization behavior of bluetongue virus serotype-16 recovered from apparently healthy goat.,2019,10.1016/j.actatropica.2019.03.018,https://pubmed.ncbi.nlm.nih.gov/30876937/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,33359401,Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease.,2021,10.1016/j.molmet.2020.101154,https://pubmed.ncbi.nlm.nih.gov/33359401/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,30232375,Loss of mitochondrial calcium uniporter rewires skeletal muscle metabolism and substrate preference.,2019,10.1038/s41418-018-0191-7,https://pubmed.ncbi.nlm.nih.gov/30232375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,32576585,"Microarray-based Analysis of Genes, Transcription Factors, and Epigenetic Modifications in Lung Cancer Exposed to Nitric Oxide.",2020,10.21873/cgp.20199,https://pubmed.ncbi.nlm.nih.gov/32576585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,32083080,Prolyl Isomerase Pin1 Regulates the Stability of Hepatitis B Virus Core Protein.,2020,10.3389/fcell.2020.00026,https://pubmed.ncbi.nlm.nih.gov/32083080/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,21718551,"RsaI repetitive DNA in Buffalo Bubalus bubalis representing retrotransposons, conserved in bovids, are part of the functional genes.",2011,10.1186/1471-2164-12-338,https://pubmed.ncbi.nlm.nih.gov/21718551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,32742935,Pitfalls of relying on genetic testing only to diagnose inherited metabolic disorders in non-western populations - 5 cases of pyruvate dehydrogenase deficiency from South Africa.,2020,10.1016/j.ymgmr.2020.100629,https://pubmed.ncbi.nlm.nih.gov/32742935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,25630799,Silencing gastrin-releasing peptide receptor suppresses key regulators of aerobic glycolysis in neuroblastoma cells.,2015,10.1002/pbc.25348,https://pubmed.ncbi.nlm.nih.gov/25630799/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PDP2,ENSG00000172840,Unsafe,18523639,"Adaptation and mal-adaptation to ambient hypoxia; Andean, Ethiopian and Himalayan patterns.",2008,10.1371/journal.pone.0002342,https://pubmed.ncbi.nlm.nih.gov/18523639/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,42902572,Proenkephalin A and Heterogeneity of Hydrocortisone Treatment Effect in Septic Shock: A Post Hoc Analysis of the VANISH Trial.,2026,10.1097/cce.0000000000001496,https://pubmed.ncbi.nlm.nih.gov/42902572/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,42653468,Non-Coding SNPs Regulate Bovine Muscle Satellite Cell Proliferation and Differentiation by Modulating &lt;i&gt;PENK&lt;/i&gt; Expression.,2026,10.3390/ijms27167467,https://pubmed.ncbi.nlm.nih.gov/42653468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,42225850,Dorsal raphe nucleus enkephalin peptide modulates behavioral preference.,2026,10.1038/s41386-026-02456-5,https://pubmed.ncbi.nlm.nih.gov/42225850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,42571388,Proenkephalin neurons in the adBNST mitigate stress-induced anxiety and estrous cycle disruption in female mice.,2026,10.1016/j.ynstr.2026.100841,https://pubmed.ncbi.nlm.nih.gov/42571388/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,42834780,Intranasal Delivery of Proenkephalin-Expressing Differentiated Mesenchymal Stem Cells Attenuates Morphine Dependence Behaviors and Modulates Neurotrophic Factors in Rats.,2026,10.1080/17590914.2026.2739826,https://pubmed.ncbi.nlm.nih.gov/42834780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,42276585,Urine IRF4/PENK/PXDN Methylation Signatures Enable Machine Learning-Driven Bladder Cancer Detection and Microenvironment Dissection.,2026,10.1177/15330338261453486,https://pubmed.ncbi.nlm.nih.gov/42276585/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,42783482,The Role of Proenkephalin in Predicting Renal Dysfunction and Mortality in Septic Patients Admitted to the Emergency Department and Intensive Care Unit: A Narrative Review.,2026,10.3390/jpm16090451,https://pubmed.ncbi.nlm.nih.gov/42783482/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,42164362,&lt;i&gt;PENK&lt;/i&gt; methylation and non-invasive bladder cancer detection.,2026,10.21037/tau-2026-1-0128,https://pubmed.ncbi.nlm.nih.gov/42164362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,42575453,Prenatal exposure to environmental stressors alters gut macrophage development and gastrointestinal function of male offspring.,2026,10.1016/j.bbi.2026.106947,https://pubmed.ncbi.nlm.nih.gov/42575453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,42571343,Proenkephalin A for assessing kidney integrity and guiding KRT liberation decisions in critically ill patients.,2026,10.1016/j.aicoj.2026.100113,https://pubmed.ncbi.nlm.nih.gov/42571343/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,42247190,Identification of hub mRNAs and long non-coding RNAs involved in temozolomide-resistant glioblastoma (brain cancer) cell lines.,2026,10.1007/s12672-026-05243-2,https://pubmed.ncbi.nlm.nih.gov/42247190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,42058429,Proenkephalin a 119-159 for evaluating glomerular filtration rate and hemodialysis adequacy in patients with end-stage kidney disease: a prospective cohort study.,2026,10.3389/fmed.2026.1762412,https://pubmed.ncbi.nlm.nih.gov/42058429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,42053115,Serum Proenkephalin A as a Marker of Renal Dysfunction and Glycemic Status in Diabetic Nephropathy.,2026,10.1177/15578518261444701,https://pubmed.ncbi.nlm.nih.gov/42053115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,41483148,IL-33 Regulates the Phenotypic Transformation of Reactive Astrocytes via PENK-ERK/MAPK Pathway in Parkinson's Disease.,2026,10.1007/s12264-025-01566-2,https://pubmed.ncbi.nlm.nih.gov/41483148/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,41000014,Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease.,2026,10.1002/mds.70062,https://pubmed.ncbi.nlm.nih.gov/41000014/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,42079646,Bioinformatics and machine learning approaches to explore the biomarkers in fatty acid degradation linked to osteoarthritis.,2026,10.3389/fimmu.2026.1778565,https://pubmed.ncbi.nlm.nih.gov/42079646/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,42360561,Aerobic Exercise Improves Motor Performance by Reducing Total ERK Expression and Hyperexcitability of Striatal D2-MSNs in MPTP-Induced Parkinsonian Mice.,2026,10.1007/s12035-026-06025-1,https://pubmed.ncbi.nlm.nih.gov/42360561/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,40283487,Proenkephalin 119-159 in Heart Failure: From Pathophysiology to Clinical Implications.,2025,10.3390/jcm14082657,https://pubmed.ncbi.nlm.nih.gov/40283487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,41667847,Multi-omics identification of key targets for the osteogenic differentiation of human bone marrow mesenchymal stromal cells under oxidative stress.,2026,10.1038/s41598-026-39818-4,https://pubmed.ncbi.nlm.nih.gov/41667847/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,41848305,Proenkephalin Inhibits the Osteogenic Differentiation of Bone Marrow-derived Mesenchymal Stem Cells.,2026,10.3290/j.cjdr.b6953758,https://pubmed.ncbi.nlm.nih.gov/41848305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,41080910,Transcriptomic Profiling of Dental Tissue-Derived Mesenchymal Stem Cells.,2025,10.1155/sci/4789882,https://pubmed.ncbi.nlm.nih.gov/41080910/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,41799329,EarlyTect BCD Plus: A urine-based dual site PENK methylation test for risk-based cystoscopy triage in haematuria.,2026,10.1002/bco2.70178,https://pubmed.ncbi.nlm.nih.gov/41799329/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,41731838,Prognostic model based on stem cells and oxidative stress related genes for ovarian cancer.,2026,10.1097/md.0000000000047461,https://pubmed.ncbi.nlm.nih.gov/41731838/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,40806634,DNA Methylation in Bladder Cancer: Diagnostic and Therapeutic Perspectives-A Narrative Review.,2025,10.3390/ijms26157507,https://pubmed.ncbi.nlm.nih.gov/40806634/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,40869560,Predictive Value of Point-of-Care Proenkephalin for Worsening Renal Function and Mortality in Patients Presenting to Emergency Department with Acute Heart Failure.,2025,10.3390/jcm14165730,https://pubmed.ncbi.nlm.nih.gov/40869560/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,40911697,Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception.,2025,10.1126/sciimmunol.adz6869,https://pubmed.ncbi.nlm.nih.gov/40911697/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,40141244,Implementation and One-Year Evaluation of Proenkephalin A in Critical Care.,2025,10.3390/ijms26062602,https://pubmed.ncbi.nlm.nih.gov/40141244/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,40359090,Proenkephalin produced by neonatal T-bet + Treg cells promotes periportal hepatocyte maturation.,2026,10.1097/hep.0000000000001389,https://pubmed.ncbi.nlm.nih.gov/40359090/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,40332103,"Markers of Kidney Injury: Proenkephalin A and Uromodulin, but Not Dickkopf-3, Are Elevated in Patients After Hematopoietic Stem Cell Transplantation.",2025,10.3390/ijms26083581,https://pubmed.ncbi.nlm.nih.gov/40332103/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,39518330,Proenkephalin A 119-159 in Perioperative and Intensive Care-A Promising Biomarker or Merely Another Option?,2024,10.3390/diagnostics14212364,https://pubmed.ncbi.nlm.nih.gov/39518330/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,39110619,Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice.,2024,10.7554/elife.91359,https://pubmed.ncbi.nlm.nih.gov/39110619/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,40958929,"Oxidative Stress and Gene Expression Dynamics: PENK, PDYN, and NRF2 in Cognitive Recovery from Opioid Withdrawal with Herbal Supplements and Aerobic Exercise.",2025,10.4103/abr.abr_631_24,https://pubmed.ncbi.nlm.nih.gov/40958929/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PENK,ENSG00000181195,Unsafe,39456654,Prediction of Successful Liberation from Continuous Renal Replacement Therapy Using a Novel Biomarker in Patients with Acute Kidney Injury after Cardiac Surgery-An Observational Trial.,2024,10.3390/ijms252010873,https://pubmed.ncbi.nlm.nih.gov/39456654/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,42466851,Cyclo-C stabilizes PEX13 to inhibit porcine epidemic diarrhea virus replication by blocking pexophagy-mediated disruption of antiviral innate immunity.,2026,10.1128/jvi.00785-26,https://pubmed.ncbi.nlm.nih.gov/42466851/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,42298691,Analysis and validation of abnormal signaling pathways and immune cell infiltration characteristics in digestive system cancers based on peroxisome-related genes.,2026,10.1186/s13062-026-00861-w,https://pubmed.ncbi.nlm.nih.gov/42298691/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,41860470,Loss of peroxisomal membrane proteins PEX13 and PEX14 disrupts fatty acid oxidation and drives lipid imbalance.,2026,10.1042/bsr20260048,https://pubmed.ncbi.nlm.nih.gov/41860470/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,41851092,Maternal obesity disrupts epigenetic reprogramming via peroxisomal-dependent phospholipid-methyl uncoupling during zygotic genome activation.,2026,10.1038/s41467-026-70492-2,https://pubmed.ncbi.nlm.nih.gov/41851092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,41186416,PEDV NSP8 inhibits IFN-III production induced by MAVS through downregulation of PEX13.,2025,10.1128/mbio.02396-25,https://pubmed.ncbi.nlm.nih.gov/41186416/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,40739340,PEX39 facilitates the peroxisomal import of PTS2-containing proteins.,2025,10.1038/s41556-025-01711-z,https://pubmed.ncbi.nlm.nih.gov/40739340/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,40243840,ZBTB17/MIZ1 promotes peroxisome biogenesis by transcriptional regulation of PEX13.,2025,10.1083/jcb.202407198,https://pubmed.ncbi.nlm.nih.gov/40243840/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,37920431,PEX13 is a potential immunotherapeutic indicator and prognostic biomarker for various tumors including PAAD.,2023,10.3892/ol.2023.14099,https://pubmed.ncbi.nlm.nih.gov/37920431/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,40346349,Import mechanism of peroxisomal proteins with an N-terminal signal sequence.,2025,10.1038/s41556-025-01662-5,https://pubmed.ncbi.nlm.nih.gov/40346349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,38632234,Modulation of peroxisomal import by the PEX13 SH3 domain and a proximal FxxxF binding motif.,2024,10.1038/s41467-024-47605-w,https://pubmed.ncbi.nlm.nih.gov/38632234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,37962062,Severe Zellweger spectrum disorder due to a novel missense variant in the PEX13 gene: A case report and the literature review.,2024,10.1002/mgg3.2315,https://pubmed.ncbi.nlm.nih.gov/37962062/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,35854306,Genotype-phenotype correlations and disease mechanisms in PEX13-related Zellweger spectrum disorders.,2022,10.1186/s13023-022-02415-5,https://pubmed.ncbi.nlm.nih.gov/35854306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,41381475,Structure of Trypanosoma peroxisomal import complex unveils conformational heterogeneity.,2025,10.1038/s41467-025-66207-8,https://pubmed.ncbi.nlm.nih.gov/41381475/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,40194601,Browning of inguinal white adipose tissue by the novel lignan (-)-secoisolariciresinol 4-O-methyl ether attenuates diet-induced obesity through mitochondrial and peroxisomal activation.,2025,10.1016/j.bbamcr.2025.119952,https://pubmed.ncbi.nlm.nih.gov/40194601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,37165185,Peroxisome biogenesis initiated by protein phase separation.,2023,10.1038/s41586-023-06044-1,https://pubmed.ncbi.nlm.nih.gov/37165185/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,41240571,Particulate matter-induced NETosis promotes peroxisomal degradation via pexophagy in neutrophils.,2025,10.1016/j.ecoenv.2025.119398,https://pubmed.ncbi.nlm.nih.gov/41240571/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,36541703,PEX13 prevents pexophagy by regulating ubiquitinated PEX5 and peroxisomal ROS.,2023,10.1080/15548627.2022.2160566,https://pubmed.ncbi.nlm.nih.gov/36541703/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,38855148,Functional transcriptome analysis revealed major changes in pathways affecting systems biology of Tharparkar cattle under seasonal heat stress.,2024,10.1007/s13205-024-04018-2,https://pubmed.ncbi.nlm.nih.gov/38855148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,39351301,Unveiling superior phenol detoxification and degradation ability in Candida tropicalis SHC-03: a comparative study with Saccharomyces cerevisiae BY4742.,2024,10.3389/fmicb.2024.1442235,https://pubmed.ncbi.nlm.nih.gov/39351301/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,34422635,Tegaserod Maleate Inhibits Esophageal Squamous Cell Carcinoma Proliferation by Suppressing the Peroxisome Pathway.,2021,10.3389/fonc.2021.683241,https://pubmed.ncbi.nlm.nih.gov/34422635/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,35488273,Integrated analysis of single-cell and bulk RNA sequencing data reveals a pan-cancer stemness signature predicting immunotherapy response.,2022,10.1186/s13073-022-01050-w,https://pubmed.ncbi.nlm.nih.gov/35488273/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,39313791,It takes two peroxisome proliferator-activated receptors (PPAR-β/δ and PPAR-γ) to tango idiopathic pulmonary fibrosis.,2024,10.1186/s12931-024-02935-7,https://pubmed.ncbi.nlm.nih.gov/39313791/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,32457250,"Decreased, Deformed, Defective-How HIV-1 Vpu Targets Peroxisomes.",2020,10.1128/mbio.00967-20,https://pubmed.ncbi.nlm.nih.gov/32457250/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,33114025,"Prevention by Dietary Polyphenols (Resveratrol, Quercetin, Apigenin) Against 7-Ketocholesterol-Induced Oxiapoptophagy in Neuronal N2a Cells: Potential Interest for the Treatment of Neurodegenerative and Age-Related Diseases.",2020,10.3390/cells9112346,https://pubmed.ncbi.nlm.nih.gov/33114025/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,30951392,Emerging views of mitophagy in immunity and autoimmune diseases.,2020,10.1080/15548627.2019.1603547,https://pubmed.ncbi.nlm.nih.gov/30951392/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,28426655,Glycosome biogenesis in trypanosomes and the de novo dilemma.,2017,10.1371/journal.pntd.0005333,https://pubmed.ncbi.nlm.nih.gov/28426655/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,10441568,PEX13 is mutated in complementation group 13 of the peroxisome-biogenesis disorders.,1999,10.1086/302534,https://pubmed.ncbi.nlm.nih.gov/10441568/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,19830841,alpha-Synuclein abnormalities in mouse models of peroxisome biogenesis disorders.,2010,10.1002/jnr.22246,https://pubmed.ncbi.nlm.nih.gov/19830841/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,26630504,Peroxisomes in Different Skeletal Cell Types during Intramembranous and Endochondral Ossification and Their Regulation during Osteoblast Differentiation by Distinct Peroxisome Proliferator-Activated Receptors.,2015,10.1371/journal.pone.0143439,https://pubmed.ncbi.nlm.nih.gov/26630504/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX13,ENSG00000162928,Unsafe,22829911,"Cre-mediated stress affects sirtuin expression levels, peroxisome biogenesis and metabolism, antioxidant and proinflammatory signaling pathways.",2012,10.1371/journal.pone.0041097,https://pubmed.ncbi.nlm.nih.gov/22829911/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,42626114,Spatial transcriptomics reveal heterogeneous cell‒cell interactions among brain regions in cuprizone model consistent with multiple sclerosis lesions.,2026,10.3389/fbinf.2026.1832826,https://pubmed.ncbi.nlm.nih.gov/42626114/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,41238648,Integrating machine learning and experimental validation identifies a post-translational modification gene signature for prognosis and treatment response in breast cancer.,2025,10.1038/s41598-025-23772-8,https://pubmed.ncbi.nlm.nih.gov/41238648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,36260915,Membrane binding and pore forming insertion of PEX5 into horizontal lipid bilayer.,2023,10.1515/hsz-2022-0183,https://pubmed.ncbi.nlm.nih.gov/36260915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,40702462,FNDC5 and ACOX1 as Biomarkers of Peroxisomal Activity with Contrast Outcomes in Colon Adenocarcinoma.,2025,10.1186/s12575-025-00289-y,https://pubmed.ncbi.nlm.nih.gov/40702462/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,36104739,PEX5R/Trip8b-HCN2 channel regulating neuroinflammation involved in perioperative neurocognitive disorders.,2022,10.1186/s13578-022-00892-6,https://pubmed.ncbi.nlm.nih.gov/36104739/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,33946275,Characterization of the HCN Interaction Partner TRIP8b/PEX5R in the Intracardiac Nervous System of TRIP8b-Deficient and Wild-Type Mice.,2021,10.3390/ijms22094772,https://pubmed.ncbi.nlm.nih.gov/33946275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,36768134,Spatial Transcriptome Profiling of Mouse Hippocampal Single Cell Microzone in Parkinson's Disease.,2023,10.3390/ijms24031810,https://pubmed.ncbi.nlm.nih.gov/36768134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,35502931,Genetic variants in DDO and PEX5L in peroxisome-related pathways predict non-small cell lung cancer survival.,2022,10.1002/mc.23400,https://pubmed.ncbi.nlm.nih.gov/35502931/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,35940876,Peroxisome Injury in Multiple Sclerosis: Protective Effects of 4-Phenylbutyrate in CNS-Associated Macrophages.,2022,10.1523/jneurosci.0312-22.2022,https://pubmed.ncbi.nlm.nih.gov/35940876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,35147292,Identification of sodium homeostasis genes in Camelus bactrianus by whole transcriptome sequencing.,2022,10.1002/2211-5463.13380,https://pubmed.ncbi.nlm.nih.gov/35147292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,37190821,COVID-19 Induces Neuroinflammation and Suppresses Peroxisomes in the Brain.,2023,10.1002/ana.26679,https://pubmed.ncbi.nlm.nih.gov/37190821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,34524914,Infection of Glia by Human Pegivirus Suppresses Peroxisomal and Antiviral Signaling Pathways.,2021,10.1128/jvi.01074-21,https://pubmed.ncbi.nlm.nih.gov/34524914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,33095298,Disease-associated HCN4 V759I variant is not sufficient to impair cardiac pacemaking.,2020,10.1007/s00424-020-02481-3,https://pubmed.ncbi.nlm.nih.gov/33095298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,34249911,Whole Transcriptome Analysis Reveals a Potential Regulatory Mechanism of LncRNA-FNIP2/miR-24-3p/FNIP2 Axis in Chicken Adipogenesis.,2021,10.3389/fcell.2021.653798,https://pubmed.ncbi.nlm.nih.gov/34249911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,25538232,Mechanistic insights into PTS2-mediated peroxisomal protein import: the co-receptor PEX5L drastically increases the interaction strength between the cargo protein and the receptor PEX7.,2015,10.1074/jbc.m114.601575,https://pubmed.ncbi.nlm.nih.gov/25538232/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,34285580,Comprehensive Analysis of Peritoneal Metastasis Sequencing Data to Identify LINC00924 as a Prognostic Biomarker in Gastric Cancer.,2021,10.2147/cmar.s318704,https://pubmed.ncbi.nlm.nih.gov/34285580/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,36868097,Expression analysis of novel long non-coding RNAs for invasive ductal and invasive lobular breast carcinoma cases.,2023,10.1016/j.prp.2023.154391,https://pubmed.ncbi.nlm.nih.gov/36868097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,26220973,"A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform.",2015,10.1093/hmg/ddv305,https://pubmed.ncbi.nlm.nih.gov/26220973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,27709012,PXR variants: the impact on drug metabolism and therapeutic responses.,2016,10.1016/j.apsb.2016.07.002,https://pubmed.ncbi.nlm.nih.gov/27709012/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,35284537,A novel 12-gene prognostic signature in breast cancer based on the tumor microenvironment.,2022,10.21037/atm-21-6748,https://pubmed.ncbi.nlm.nih.gov/35284537/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PEX5L,ENSG00000114757,Unsafe,11463335,Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals.,2001,10.1042/0264-6021:3570635,https://pubmed.ncbi.nlm.nih.gov/11463335/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN4,ENSG00000176732,Unsafe,35950913,PFN4 is required for manchette development and acrosome biogenesis during mouse spermiogenesis.,2022,10.1242/dev.200499,https://pubmed.ncbi.nlm.nih.gov/35950913/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN4,ENSG00000176732,Unsafe,39278335,Key role of CYP17A1 in Leydig cell function and testicular development in Qianbei Ma goats.,2025,10.1016/j.ygeno.2024.110937,https://pubmed.ncbi.nlm.nih.gov/39278335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN4,ENSG00000176732,Unsafe,33775850,Profilin 3 genetic architecture in glioma formalin fixed paraffin embedded (FFPE) archive.,2021,10.1016/j.gene.2021.145614,https://pubmed.ncbi.nlm.nih.gov/33775850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN4,ENSG00000176732,Unsafe,27185630,Distribution analysis of profilin isoforms at transcript resolution with mRNA-seq and secondary structure in various organs of Rattus norvegicus.,2016,10.1016/j.gene.2016.05.023,https://pubmed.ncbi.nlm.nih.gov/27185630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN4,ENSG00000176732,Unsafe,33438010,Single-cell ATAC-Seq reveals cell type-specific transcriptional regulation and unique chromatin accessibility in human spermatogenesis.,2022,10.1093/hmg/ddab006,https://pubmed.ncbi.nlm.nih.gov/33438010/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN4,ENSG00000176732,Unsafe,19419568,Testis-expressed profilins 3 and 4 show distinct functional characteristics and localize in the acroplaxome-manchette complex in spermatids.,2009,10.1186/1471-2121-10-34,https://pubmed.ncbi.nlm.nih.gov/19419568/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN4,ENSG00000176732,Unsafe,11549015,Heterologous expression of the Bacillus pumilus endo-beta-xylanase (xynA) gene in the yeast Saccharomyces cerevisiae.,2001,10.1007/s002530100670,https://pubmed.ncbi.nlm.nih.gov/11549015/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN4,ENSG00000176732,Unsafe,8771785,Arabidopsis profilins are functionally similar to yeast profilins: identification of a vascular bundle-specific profilin and a pollen-specific profilin.,1996,10.1046/j.1365-313x.1996.10020269.x,https://pubmed.ncbi.nlm.nih.gov/8771785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN4,ENSG00000176732,Unsafe,1349602,"Cloning, sequencing, and molecular analysis of the groESL operon of Clostridium acetobutylicum.",1992,10.1128/jb.174.10.3282-3289.1992,https://pubmed.ncbi.nlm.nih.gov/1349602/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PFN4,ENSG00000176732,Unsafe,15591451,Novel testis-expressed profilin IV associated with acrosome biogenesis and spermatid elongation.,2005,10.1093/molehr/gah132,https://pubmed.ncbi.nlm.nih.gov/15591451/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,42763477,ZO-2 blocks the localization of PGAM5 protein to the mitochondrial membrane and suppresses pancreatic cancer malignancy through metabolic reprogramming.,2027,10.1016/j.gendis.2026.102290,https://pubmed.ncbi.nlm.nih.gov/42763477/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,42209652,Unveiling the novel role of PGAM5 in rewiring metabolism through PI3K/AKT/mTOR signaling in acute myelogenous leukemia.,2026,10.1038/s41598-026-55582-x,https://pubmed.ncbi.nlm.nih.gov/42209652/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,42762130,Mitochondrial phosphatase PGAM5 negatively regulates the induction of anti-inflammatory macrophages.,2026,10.1093/jleuko/qiag127,https://pubmed.ncbi.nlm.nih.gov/42762130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,42402000,Butyrylated PGAM5-Triggered and GSH-Responsive Cysteine Polymer Nanoparticles for CBL0137 Delivery to Enhance Necroptosis in Prostate Cancer.,2026,10.1002/adhm.71387,https://pubmed.ncbi.nlm.nih.gov/42402000/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,41933402,Electroacupuncture inhibited neuronal apoptosis through PGAM5/FUNDC1-dependent mitophagy after ischemic stroke.,2026,10.1186/s13020-026-01383-3,https://pubmed.ncbi.nlm.nih.gov/41933402/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,41201111,USP11-PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA-cGAS-STING Pathway After Intracerebral Hemorrhage.,2026,10.1002/advs.202514283,https://pubmed.ncbi.nlm.nih.gov/41201111/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,42801553,LAPTM5 Downregulation-Driven VAMP8 Phosphorylation Impairs Autophagosome-Lysosome Fusion and Aggravates Septic Acute Lung Injury.,2026,10.1002/advs.78024,https://pubmed.ncbi.nlm.nih.gov/42801553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,42442117,Targeted degradation of hepatic KEAP1 mitigates drug-induced liver injury via dual boosting NRF2 and PGAM5 signaling.,2026,10.1016/j.redox.2026.104296,https://pubmed.ncbi.nlm.nih.gov/42442117/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,42632528,Phosphoglycerate mutase 5 regulates lipid metabolism and mitochondrial homeostasis in hepatocellular cancer cells.,2026,10.1016/j.cellsig.2026.112833,https://pubmed.ncbi.nlm.nih.gov/42632528/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,41723122,Targeting mitochondrial phosphatase PGAM5 alleviates ferroptosis and acute pancreatitis by upregulating NRF2-mediated FSP1 expression.,2026,10.1038/s41419-026-08484-9,https://pubmed.ncbi.nlm.nih.gov/41723122/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,42628894,PGAM5-mediated VDAC1 oligomerization facilitates ponatinib-induced cardiotoxicity via disrupting the mitophagy-mitochondrial unfolded protein response synergistic defense crosstalk.,2026,10.1016/j.cbi.2026.112310,https://pubmed.ncbi.nlm.nih.gov/42628894/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,39930129,The dual role of PGAM5 in inflammation.,2025,10.1038/s12276-025-01391-7,https://pubmed.ncbi.nlm.nih.gov/39930129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,41462565,Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease.,2026,10.1002/advs.202515138,https://pubmed.ncbi.nlm.nih.gov/41462565/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,41270215,Leucine-Dependent SLC7A5-PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages.,2026,10.1002/advs.202518359,https://pubmed.ncbi.nlm.nih.gov/41270215/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,42288162,Notoginsenoside R1 interferes with PGAM5-NEK7 interaction to inhibit NLRP3 inflammasome activation in macrophages and ameliorate DSS-induced colitis.,2026,10.1016/j.jep.2026.122036,https://pubmed.ncbi.nlm.nih.gov/42288162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,41985761,PGAM5 modulates PI3K/AKT/mTOR-dependent mitochondrial homeostasis in sepsis-induced acute kidney injury.,2026,10.1016/j.taap.2026.117812,https://pubmed.ncbi.nlm.nih.gov/41985761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,42869819,"[Effects and mechanisms of Abelmoschus manihot-derived extracellular vesicle-like particles in inhibiting podocyte oxeiptosis in diabetic kidney disease by targeted regulation of ""mitochondria-endoplasmic reticulum coupling""].",2026,10.19540/j.cnki.cjcmm.20260629.701,https://pubmed.ncbi.nlm.nih.gov/42869819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,42792820,Oxeiptosis-Associated Molecular Subtyping and Immune Microenvironment Heterogeneity in Osteoarthritis.,2026,10.3390/biomedicines14092079,https://pubmed.ncbi.nlm.nih.gov/42792820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,42681676,Targeting breast cancer stem cells by restoring RBM38 function: mechanism and protein delivery therapy.,2026,10.1186/s40364-026-00984-2,https://pubmed.ncbi.nlm.nih.gov/42681676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,42027993,Lycopene Alleviates Deoxynivalenol-Induced Porcine Intestinal Epithelial Barrier Injury by Inhibiting PGAM5-Mediated Mitophagy-Dependent Ferroptosis.,2026,10.34133/research.1251,https://pubmed.ncbi.nlm.nih.gov/42027993/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,42378634,Lactate-Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo-Immunotherapy by Suppressing Tumor PANoptosis.,2026,10.1002/advs.76321,https://pubmed.ncbi.nlm.nih.gov/42378634/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,41797878,Ubiquitin E3 ligase KLHL6 brings exhausted T-cells back into action.,2026,10.1007/s44466-026-00032-6,https://pubmed.ncbi.nlm.nih.gov/41797878/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,41880009,Targeting the USP7-PGAM5 axis overcomes oxaliplatin resistance in colorectal cancer.,2026,10.1007/s11033-026-11722-0,https://pubmed.ncbi.nlm.nih.gov/41880009/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,41633487,Screening and identification of a novel PGAM5-specific inhibitor for attenuating multi-organ injury.,2026,10.1016/j.jare.2026.01.075,https://pubmed.ncbi.nlm.nih.gov/41633487/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,42797377,Transcriptional Regulation of Receptor-Mediated Mitophagy in Sunitinib-Resistant Renal Cancer Cells: Response to Succinic Acid.,2026,10.3390/ph19091331,https://pubmed.ncbi.nlm.nih.gov/42797377/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,39773565,Disruption of tumor-intrinsic PGAM5 increases anti-PD-1 efficacy through the CCL2 signaling pathway.,2025,10.1136/jitc-2024-009993,https://pubmed.ncbi.nlm.nih.gov/39773565/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,42128272,MOTS-c attenuates hyperoxia-induced neonatal cardiac injury by inhibiting oxeiptosis via maintaining the KEAP1-PGAM5 interaction.,2026,10.1016/j.lfs.2026.124452,https://pubmed.ncbi.nlm.nih.gov/42128272/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,41535474,The ubiquitin ligase KLHL6 drives resistance to CD8&lt;sup&gt;+&lt;/sup&gt; T cell dysfunction.,2026,10.1038/s41586-025-09926-8,https://pubmed.ncbi.nlm.nih.gov/41535474/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,41891155,Oxeiptosis - potential in cancer treatment?,2026,10.1017/erm.2026.10045,https://pubmed.ncbi.nlm.nih.gov/41891155/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,42013791,RIPK1-driven calcium overload and lysosomal-mitochondrial dysfunction induce testicular necroptosis following DEHP exposure.,2026,10.1016/j.ecoenv.2026.120163,https://pubmed.ncbi.nlm.nih.gov/42013791/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGAM5,ENSG00000247077,Unsafe,40945834,A Trichinella spiralis serine protease mediates larva invasion of gut mucosa via inducing enterocyte apoptosis and damaging barrier integrity in mice.,2025,10.1016/j.ijbiomac.2025.147593,https://pubmed.ncbi.nlm.nih.gov/40945834/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGBD4,ENSG00000182405,Unsafe,41463182,Identification of Novel Susceptibility Genes for Early-Onset Colorectal Cancer Through Germline Rare Variant Burden Testing.,2025,10.3390/cancers17243931,https://pubmed.ncbi.nlm.nih.gov/41463182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGBD4,ENSG00000182405,Unsafe,34619323,Genome-wide analysis of long non-coding RNAs and their association with wing development in Aphis citricidus (Hemiptera: Aphididae).,2021,10.1016/j.ibmb.2021.103666,https://pubmed.ncbi.nlm.nih.gov/34619323/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PGBD4,ENSG00000182405,Unsafe,26459857,A functional genomics screen identifies an Importin-α homolog as a regulator of stem cell function and tissue patterning during planarian regeneration.,2015,10.1186/s12864-015-1979-1,https://pubmed.ncbi.nlm.nih.gov/26459857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,42218960,Circ-PHC3 promotes malignant progression of ovarian cancer through regulating miR-512-3p/SLC2A1/HK2 mediated glucose metabolism.,2026,10.1016/j.trsl.2026.05.007,https://pubmed.ncbi.nlm.nih.gov/42218960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,40003978,Prion-like Properties of Short Isoforms of Human Chromatin Modifier PHC3.,2025,10.3390/ijms26041512,https://pubmed.ncbi.nlm.nih.gov/40003978/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,42155289,The circular RNA Phc3 promotes the repair of damage to the intestinal mucosal barrier by regulating the miR-93/PHF6 and ACTN4 pathways.,2026,10.1016/j.burns.2026.108056,https://pubmed.ncbi.nlm.nih.gov/42155289/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,37468993,Expression of circ-PHC3 enhances ovarian cancer progression via regulation of the miR-497-5p/SOX9 pathway.,2023,10.1186/s13048-023-01170-w,https://pubmed.ncbi.nlm.nih.gov/37468993/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,34424425,Sulforaphane inhibits self-renewal of lung cancer stem cells through the modulation of sonic Hedgehog signaling pathway and polyhomeotic homolog 3.,2021,10.1186/s13568-021-01281-x,https://pubmed.ncbi.nlm.nih.gov/34424425/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,38139423,"Based on Transcriptome Sequencing of Cell Wall Deficient Strain, Research on Arabinosyltransferase Inhibition's Effect on the Synthesis of Cell Wall in Chlamydomonas reinhardtii.",2023,10.3390/ijms242417595,https://pubmed.ncbi.nlm.nih.gov/38139423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,32890709,Pharmacological and pharmacokinetic effect of a polyherbal combination with Withania somnifera (L.) Dunal for the management of anxiety.,2021,10.1016/j.jep.2020.113337,https://pubmed.ncbi.nlm.nih.gov/32890709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,38329630,Hypoxia increases the biogenesis of IGF2BP3-bound circular RNAs.,2024,10.1007/s11033-024-09230-0,https://pubmed.ncbi.nlm.nih.gov/38329630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,31784561,Construction of miRNA-target networks using microRNA profiles of CVB3-infected HeLa cells.,2019,10.1038/s41598-019-54188-w,https://pubmed.ncbi.nlm.nih.gov/31784561/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,32098402,The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer.,2020,10.3390/cancers12020513,https://pubmed.ncbi.nlm.nih.gov/32098402/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,23942079,Mutational analysis of Polycomb genes in solid tumours identifies PHC3 amplification as a possible cancer-driving genetic alteration.,2013,10.1038/bjc.2013.454,https://pubmed.ncbi.nlm.nih.gov/23942079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,25044168,Multiple polymer architectures of human polyhomeotic homolog 3 sterile alpha motif.,2014,10.1002/prot.24645,https://pubmed.ncbi.nlm.nih.gov/25044168/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,31393953,Identification of murine gammaherpesvirus 68 miRNA-mRNA hybrids reveals miRNA target conservation among gammaherpesviruses including host translation and protein modification machinery.,2019,10.1371/journal.ppat.1007843,https://pubmed.ncbi.nlm.nih.gov/31393953/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,20491773,Polycomb group molecule PHC3 regulates polycomb complex composition and prognosis of osteosarcoma.,2010,10.1111/j.1349-7006.2010.01586.x,https://pubmed.ncbi.nlm.nih.gov/20491773/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,22724443,Human polyhomeotic homolog 3 (PHC3) sterile alpha motif (SAM) linker allows open-ended polymerization of PHC3 SAM.,2012,10.1021/bi3004318,https://pubmed.ncbi.nlm.nih.gov/22724443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,17001316,"PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors.",2007,10.1038/sj.onc.1209988,https://pubmed.ncbi.nlm.nih.gov/17001316/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,26343356,Polycomb genes are associated with response to imatinib in chronic myeloid leukemia.,2015,10.2217/epi.15.35,https://pubmed.ncbi.nlm.nih.gov/26343356/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,16824181,A mutation in the GTP hydrolysis site of Arabidopsis dynamin-related protein 1E confers enhanced cell death in response to powdery mildew infection.,2006,10.1111/j.1365-313x.2006.02769.x,https://pubmed.ncbi.nlm.nih.gov/16824181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,21948523,Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant.,2011,10.1101/gr.116442.110,https://pubmed.ncbi.nlm.nih.gov/21948523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,21602154,[Protective effects of penehyclidine hydrochloride against acute renal injury induced by hemorrhagic shock and lipopolysaccharides in rats].,2011,,https://pubmed.ncbi.nlm.nih.gov/21602154/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,8745454,[In vivo tissue distribution of laryngeal cancer drained lymph node lymphocytes in tumor-bearing mice].,1995,,https://pubmed.ncbi.nlm.nih.gov/8745454/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHC3,ENSG00000173889,Unsafe,9275399,[The experimental treatment of laryngeal cancer using local draining lymph node lymphocytes].,1996,,https://pubmed.ncbi.nlm.nih.gov/9275399/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,40631661,Cellular Reprogramming by PHF7 Enhances Cardiac Function Following Myocardial Infarction.,2025,10.1161/circulationaha.124.072733,https://pubmed.ncbi.nlm.nih.gov/40631661/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,37920670,Loss of histone reader Phf7 leads to immune pathways activation via endogenous retroviruses during spermiogenesis.,2023,10.1016/j.isci.2023.108030,https://pubmed.ncbi.nlm.nih.gov/37920670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,36548300,Safeguarding Drosophila female germ cell identity depends on an H3K9me3 mini domain guided by a ZAD zinc finger protein.,2022,10.1371/journal.pgen.1010568,https://pubmed.ncbi.nlm.nih.gov/36548300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,38430697,Phf7 has impacts on the body growth and bone remodeling by regulating testicular hormones in male mice.,2024,10.1016/j.bbrc.2024.149596,https://pubmed.ncbi.nlm.nih.gov/38430697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,32816970,An autoregulatory switch in sex-specific phf7 transcription causes loss of sexual identity and tumors in the Drosophila female germline.,2020,10.1242/dev.192856,https://pubmed.ncbi.nlm.nih.gov/32816970/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,37993255,Molecular basis for PHF7-mediated ubiquitination of histone H3.,2023,10.1101/gad.350989.123,https://pubmed.ncbi.nlm.nih.gov/37993255/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,33737548,Germline masculinization by Phf7 in D. melanogaster requires its evolutionarily novel C-terminus and the HP1-family protein HP1D3csd.,2021,10.1038/s41598-021-85560-4,https://pubmed.ncbi.nlm.nih.gov/33737548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,35716824,Expanding duplication of the testis PHD Finger Protein 7 (PHF7) gene in the chicken genome.,2022,10.1016/j.ygeno.2022.110411,https://pubmed.ncbi.nlm.nih.gov/35716824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,30297796,The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells.,2018,10.1038/s41467-018-06697-x,https://pubmed.ncbi.nlm.nih.gov/30297796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,35385723,Germline sex determination regulates sex-specific signaling between germline stem cells and their niche.,2022,10.1016/j.celrep.2022.110620,https://pubmed.ncbi.nlm.nih.gov/35385723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,35324887,Stonewall prevents expression of ectopic genes in the ovary and accumulates at insulator elements in D. melanogaster.,2022,10.1371/journal.pgen.1010110,https://pubmed.ncbi.nlm.nih.gov/35324887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,37059098,Genetic control of a sex-specific piRNA program.,2023,10.1016/j.cub.2023.03.057,https://pubmed.ncbi.nlm.nih.gov/37059098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,28588035,Control of a Novel Spermatocyte-Promoting Factor by the Male Germline Sex Determination Factor PHF7 of Drosophila melanogaster.,2017,10.1534/genetics.117.199935,https://pubmed.ncbi.nlm.nih.gov/28588035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,31453329,The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy in Drosophila.,2019,10.1126/sciadv.aaw7965,https://pubmed.ncbi.nlm.nih.gov/31453329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,33941892,The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming.,2021,10.1038/s41556-021-00668-z,https://pubmed.ncbi.nlm.nih.gov/33941892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,32726616,PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis.,2020,10.1016/j.celrep.2020.107950,https://pubmed.ncbi.nlm.nih.gov/32726616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,31189663,PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine exchange during spermiogenesis.,2019,10.1242/dev.175547,https://pubmed.ncbi.nlm.nih.gov/31189663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,28539513,Evidence for parallel evolution of a gene involved in the regulation of spermatogenesis.,2017,10.1098/rspb.2017.0324,https://pubmed.ncbi.nlm.nih.gov/28539513/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,28912601,"PHF7, a novel male gene influences female fecundity and population growth in Nilaparvata lugens Stål (Hemiptera: Delphacidae).",2017,10.1038/s41598-017-11524-2,https://pubmed.ncbi.nlm.nih.gov/28912601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,31329582,Tudor-domain containing protein 5-like promotes male sexual identity in the Drosophila germline and is repressed in females by Sex lethal.,2019,10.1371/journal.pgen.1007617,https://pubmed.ncbi.nlm.nih.gov/31329582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHF7,ENSG00000010318,Unsafe,11829468,"NYD-SP6, a novel gene potentially involved in regulating testicular development/spermatogenesis.",2002,10.1006/bbrc.2002.6396,https://pubmed.ncbi.nlm.nih.gov/11829468/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,42717495,TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton.,2026,10.1002/advs.77671,https://pubmed.ncbi.nlm.nih.gov/42717495/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,42744198,"PHOSPHO1 deficiency delays osteogenic differentiation of osteoblasts, impairing mineralization and altering the protein composition of matrix vesicles.",2026,10.1016/j.bone.2026.118096,https://pubmed.ncbi.nlm.nih.gov/42744198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,42791579,Reversing detrimental effects of OA-related terminal maturation in high-throughput in vitro and biomimetic ex vivo human models.,2026,10.1186/s13075-026-03903-w,https://pubmed.ncbi.nlm.nih.gov/42791579/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,42386140,Disrupted phosphate metabolism and SIBLING/ASARM peptide accumulation underlie impaired bone mineralization in klotho-deficient (kl/kl) mice.,2026,10.1016/j.bone.2026.118002,https://pubmed.ncbi.nlm.nih.gov/42386140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,41664674,Methylation analysis of &lt;i&gt;PHOSPHO1&lt;/i&gt; and &lt;i&gt;ACACA&lt;/i&gt; gene promoters in whole blood samples: insights into metabolic syndrome and associated factors.,2026,10.1007/s40200-026-01881-z,https://pubmed.ncbi.nlm.nih.gov/41664674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,40396905,PHOSPHO1 Suppresses Ferroptosis in Retinal Pigment Epithelial Cells by Reducing the Levels of Phosphatidylethanolamine Molecular Species.,2025,10.1002/advs.202505359,https://pubmed.ncbi.nlm.nih.gov/40396905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,40574346,Co-overexpression of the caloric restriction-induced mitochondrial factors PGC-1α and MIPEP upregulates Phospho1 expression in adipocytes.,2025,10.1002/2211-5463.70077,https://pubmed.ncbi.nlm.nih.gov/40574346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,40791815,Osteoblasts sense extracellular levels of phosphate to control the local expression of phosphatases for matrix mineralisation.,2025,10.1016/j.bonr.2025.101863,https://pubmed.ncbi.nlm.nih.gov/40791815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,40470038,Distinct bone metabolic networks identified in &lt;i&gt;Phospho&lt;/i&gt;1&lt;sup&gt;-/-&lt;/sup&gt; mice vs. wild type mice using [&lt;sup&gt;18&lt;/sup&gt;F]FDG total-body PET.,2025,10.3389/fmed.2025.1597844,https://pubmed.ncbi.nlm.nih.gov/40470038/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,42578888,Genetic evidence linking circadian rhythm genes and hypertension: A two-sample Mendelian randomization study.,2026,10.1177/03000605261474730,https://pubmed.ncbi.nlm.nih.gov/42578888/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,40591616,Identification of plasma proteins associated with seizures in epilepsy: A consensus machine learning approach.,2025,10.1371/journal.pone.0327317,https://pubmed.ncbi.nlm.nih.gov/40591616/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,41982404,Genomic Insights Into Carnivorous Fish in the Characiformes.,2026,10.1002/ece3.73478,https://pubmed.ncbi.nlm.nih.gov/41982404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,41415870,The Effect of Proton Pump Inhibitors on Bone Mineralisation &lt;i&gt;A Systematic Review with Focus on PHOSPHO1&lt;/i&gt;.,2025,10.18295/2075-0528.2920,https://pubmed.ncbi.nlm.nih.gov/41415870/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,40646863,Integrated mRNA and miRNA Analysis Reveals Layer-Specific Mechanisms of Antler Yield Variation in Sika Deer.,2025,10.3390/ani15131964,https://pubmed.ncbi.nlm.nih.gov/40646863/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,41846435,Impact of Gene Duplication of B4GALNT2 in Pigs for Xenotransplantation- Technical &amp; Practical.,2026,10.1111/xen.70115,https://pubmed.ncbi.nlm.nih.gov/41846435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,38572109,Repurposing lansoprazole to alleviate metabolic syndrome via PHOSPHO1 inhibition.,2024,10.1016/j.apsb.2024.01.001,https://pubmed.ncbi.nlm.nih.gov/38572109/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,41714054,Abaloparatide increases bone mass by increasing bone formation regardless of alendronate pretreatment in mice.,2026,10.1016/j.job.2025.100708,https://pubmed.ncbi.nlm.nih.gov/41714054/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,40254128,Histochemical assessment of the anabolic effects of abaloparatide on the femoral metaphyses of ovariectomized mice.,2025,10.1016/j.job.2025.100663,https://pubmed.ncbi.nlm.nih.gov/40254128/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,38942193,"Regional difference in the distribution of alkaline phosphatase, PHOSPHO1, and calcein labeling in the femoral metaphyseal trabeculae in parathyroid hormone-administered mice.",2024,10.1016/j.job.2024.06.007,https://pubmed.ncbi.nlm.nih.gov/38942193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,35957983,The emerging roles of PHOSPHO1 and its regulated phospholipid homeostasis in metabolic disorders.,2022,10.3389/fphys.2022.935195,https://pubmed.ncbi.nlm.nih.gov/35957983/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,39604668,CD8 + T-Cell-Related Genes: Deciphering Their Role in the Pancreatic Adenocarcinoma TME and Their Effect on Prognosis.,2025,10.1007/s10620-024-08715-z,https://pubmed.ncbi.nlm.nih.gov/39604668/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,35943680,PHOSPHO1 Serves as a Key Metabolism-Related Biomarker in the Tumorigenesis of Diffuse Large B-cell Lymphoma.,2022,10.1007/s11596-022-2612-6,https://pubmed.ncbi.nlm.nih.gov/35943680/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,38530899,Phosphocholine-induced energy source shift alleviates mitochondrial dysfunction in lung cells caused by geospecific PM&lt;sub&gt;2.5&lt;/sub&gt; components.,2024,10.1073/pnas.2317574121,https://pubmed.ncbi.nlm.nih.gov/38530899/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,34213594,Proton Pump Inhibitors Inhibit PHOSPHO1 Activity and Matrix Mineralisation In Vitro.,2021,10.1007/s00223-021-00882-9,https://pubmed.ncbi.nlm.nih.gov/34213594/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,32554489,Phosphocholine accumulation and PHOSPHO1 depletion promote adipose tissue thermogenesis.,2020,10.1073/pnas.1916550117,https://pubmed.ncbi.nlm.nih.gov/32554489/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,31372594,"How To Build a Bone: PHOSPHO1, Biomineralization, and Beyond.",2019,10.1002/jbm4.10202,https://pubmed.ncbi.nlm.nih.gov/31372594/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,35655232,Effects of DNA methylation on cardiometabolic risk factors: a systematic review and meta-analysis.,2022,10.1186/s13690-022-00907-1,https://pubmed.ncbi.nlm.nih.gov/35655232/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,38435029,Transcriptome Analysis Identifies Tumor Immune Microenvironment Signaling Networks Supporting Metastatic Castration-Resistant Prostate Cancer.,2023,10.3390/onco3020007,https://pubmed.ncbi.nlm.nih.gov/38435029/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,26457330,The Functional co-operativity of Tissue-Nonspecific Alkaline Phosphatase (TNAP) and PHOSPHO1 during initiation of Skeletal Mineralization.,2015,10.1016/j.bbrep.2015.09.013,https://pubmed.ncbi.nlm.nih.gov/26457330/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,25124115,"Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1.",2014,10.1016/j.bmcl.2014.07.013,https://pubmed.ncbi.nlm.nih.gov/25124115/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,22887744,Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification.,2013,10.1002/jbmr.1733,https://pubmed.ncbi.nlm.nih.gov/22887744/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHOSPHO1,ENSG00000173868,Unsafe,15050893,PHOSPHO1-A novel phosphatase specifically expressed at sites of mineralisation in bone and cartilage.,2004,10.1016/j.bone.2003.12.023,https://pubmed.ncbi.nlm.nih.gov/15050893/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHTF1,ENSG00000116793,Unsafe,36803935,Structural screens identify candidate human homologs of insect chemoreceptors and cryptic Drosophila gustatory receptor-like proteins.,2023,10.7554/elife.85537,https://pubmed.ncbi.nlm.nih.gov/36803935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHTF1,ENSG00000116793,Unsafe,26448723,Analysis of the expression of PHTF1 and related genes in acute lymphoblastic leukemia.,2015,10.1186/s12935-015-0242-9,https://pubmed.ncbi.nlm.nih.gov/26448723/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHTF1,ENSG00000116793,Unsafe,34234497,Associations of GWAS-Supported Non-MHC Genes with Autoimmune Thyroiditis in Patients with Type 1 Diabetes.,2021,10.2147/dmso.s319630,https://pubmed.ncbi.nlm.nih.gov/34234497/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHTF1,ENSG00000116793,Unsafe,33740106,Identification of Novel Pleiotropic SNPs Associated with Osteoporosis and Rheumatoid Arthritis.,2021,10.1007/s00223-021-00817-4,https://pubmed.ncbi.nlm.nih.gov/33740106/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHTF1,ENSG00000116793,Unsafe,34869219,Unveiling the Enzymatic Degradation Process of Biobased Thiophene Polyesters.,2021,10.3389/fchem.2021.771612,https://pubmed.ncbi.nlm.nih.gov/34869219/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHTF1,ENSG00000116793,Unsafe,33288658,Genetic Variants Associated with Therapy-Related Cardiomyopathy among Childhood Cancer Survivors of African Ancestry.,2021,10.1158/0008-5472.can-20-2675,https://pubmed.ncbi.nlm.nih.gov/33288658/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHTF1,ENSG00000116793,Unsafe,26472073,Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors.,2015,10.1093/hmg/ddv432,https://pubmed.ncbi.nlm.nih.gov/26472073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHTF1,ENSG00000116793,Unsafe,10729229,Molecular characterization of a novel gene family (PHTF) conserved from Drosophila to mammals.,2000,10.1006/geno.1999.6079,https://pubmed.ncbi.nlm.nih.gov/10729229/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHTF1,ENSG00000116793,Unsafe,32423081,Transcriptomic Analysis of Mating Responses in Bemisia tabaci MED Females.,2020,10.3390/insects11050308,https://pubmed.ncbi.nlm.nih.gov/32423081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHTF1,ENSG00000116793,Unsafe,27486433,Association Studies of the GPR103 and BCL2L15 Genes in Autoimmune Thyroid Disease in the Japanese Population.,2016,10.3389/fendo.2016.00092,https://pubmed.ncbi.nlm.nih.gov/27486433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHTF1,ENSG00000116793,Unsafe,15601915,Putative homeodomain transcription factor 1 interacts with the feminization factor homolog fem1b in male germ cells.,2005,10.1095/biolreprod.104.035964,https://pubmed.ncbi.nlm.nih.gov/15601915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHTF1,ENSG00000116793,Unsafe,15342352,"Expression, regulation, and immunolocalization of putative homeodomain transcription factor 1 (PHTF1) in rodent epididymis: evidence for a novel form resulting from proteolytic cleavage.",2005,10.1095/biolreprod.104.029850,https://pubmed.ncbi.nlm.nih.gov/15342352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHTF1,ENSG00000116793,Unsafe,12604659,Phtf1 is an integral membrane protein localized in an endoplasmic reticulum domain in maturing male germ cells.,2003,10.1095/biolreprod.102.009787,https://pubmed.ncbi.nlm.nih.gov/12604659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHTF1,ENSG00000116793,Unsafe,27898717,Gene-Based Genome-Wide Association Analysis in European and Asian Populations Identified Novel Genes for Rheumatoid Arthritis.,2016,10.1371/journal.pone.0167212,https://pubmed.ncbi.nlm.nih.gov/27898717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHTF1,ENSG00000116793,Unsafe,8407821,"Genetic organization of a cluster of genes involved in the production of phaseolotoxin, a toxin produced by Pseudomonas syringae pv. phaseolicola.",1993,10.1128/jb.175.20.6451-6458.1993,https://pubmed.ncbi.nlm.nih.gov/8407821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PHTF1,ENSG00000116793,Unsafe,22326526,LADA and T1D in Estonian population - two different genetic risk profiles.,2012,10.1016/j.gene.2012.01.089,https://pubmed.ncbi.nlm.nih.gov/22326526/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,42811993,PIAS2 Overexpression Attenuates Erastin-Induced Ferroptotic Changes and Is Associated With Increased GPX4 Protein and Enhanced GPX4-Related SUMO3 Signaling in Hepatocellular Carcinoma Cells.,2026,10.31083/fbl53367,https://pubmed.ncbi.nlm.nih.gov/42811993/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,42899482,Tumour Antigen-Specific Antibody Signatures as Diagnostic Biomarkers for Melanoma.,2026,10.1002/ijc.70726,https://pubmed.ncbi.nlm.nih.gov/42899482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,42413838,Molecular cloning and functional characterization of PIASx from Epinephelus coioides reveals its negative regulatory role in antiviral immunity.,2026,10.1016/j.fsi.2026.111585,https://pubmed.ncbi.nlm.nih.gov/42413838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,41220303,Protein Inhibitor of Activated STAT2 Protects against Podocyte Injury in Diabetic Nephropathy via Inhibiting JAK2/STAT3 Pathway.,2025,10.1159/000549274,https://pubmed.ncbi.nlm.nih.gov/41220303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,41261346,Multi-omics analysis reveals PIAS family gene dysregulation as a driver of head and neck squamous cell carcinoma (HNSC) progression and therapeutic vulnerability.,2025,10.1007/s12672-025-04100-y,https://pubmed.ncbi.nlm.nih.gov/41261346/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,41413919,Chicken PIAS2 enhances H6N2 avian influenza virus replication by promoting SUMOylation of viral NP.,2025,10.1186/s13567-025-01702-w,https://pubmed.ncbi.nlm.nih.gov/41413919/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,42123509,Genome-Wide CRISPR Screening Identifies Genetic Modulators of Amyloid Precursor Protein Processing.,2026,10.3390/ijms27093926,https://pubmed.ncbi.nlm.nih.gov/42123509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,41121482,Functional Characterization and Prognostic Value of PIAS Family Genes in Liver Hepatocellular Carcinoma.,2025,10.2174/0115680096390042250929110047,https://pubmed.ncbi.nlm.nih.gov/41121482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,39347031,Protein inhibitor of activated signal transducer and activator of transcription 2 is an oncoprotein in oral squamous cell carcinoma and related to cigarette smoking - An in vitro study.,2024,10.1016/j.jds.2024.07.013,https://pubmed.ncbi.nlm.nih.gov/39347031/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,39678595,"PIAS family gene expression: implications for prognosis, immunomodulation, and chemotherapy response.",2024,10.62347/jrdp4018,https://pubmed.ncbi.nlm.nih.gov/39678595/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,38744818,dsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe.,2024,10.1038/s41467-024-47751-1,https://pubmed.ncbi.nlm.nih.gov/38744818/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,39286522,"SUMO1 modification of 0N4R-tau is regulated by PIASx, SENP1, SENP2, and TRIM11.",2024,10.1016/j.bbrep.2024.101800,https://pubmed.ncbi.nlm.nih.gov/39286522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,39432240,Pharmacologic Induction of ERα SUMOylation Disrupts Its Chromatin Binding.,2024,10.1021/acschembio.4c00606,https://pubmed.ncbi.nlm.nih.gov/39432240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,41531124,EIF2AK2 Globally Binds and Regulates the Expression and Alternative Splicing of T2D-Related Genes in INS1 Cell.,2026,10.1111/cbdd.70242,https://pubmed.ncbi.nlm.nih.gov/41531124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,37481078,IL-17 promotes melanoma through TRAF2 as a scaffold protein recruiting PIAS2 and ELAVL1 to induce EPHA5.,2023,10.1016/j.bbamcr.2023.119547,https://pubmed.ncbi.nlm.nih.gov/37481078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,34234281,PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia.,2021,10.1038/s41380-021-01207-w,https://pubmed.ncbi.nlm.nih.gov/34234281/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,36251411,Integrative transcriptome analysis reveals TEKT2 and PIAS2 involvement in diabetic nephropathy.,2022,10.1096/fj.202200740rr,https://pubmed.ncbi.nlm.nih.gov/36251411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,37531430,SUMO-activated target traps (SATTs) enable the identification of a comprehensive E3-specific SUMO proteome.,2023,10.1126/sciadv.adh2073,https://pubmed.ncbi.nlm.nih.gov/37531430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,35473503,Curcumin relieved the rheumatoid arthritis progression via modulating the linc00052/miR-126-5p/PIAS2 axis.,2022,10.1080/21655979.2022.2066760,https://pubmed.ncbi.nlm.nih.gov/35473503/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,38023123,Transient TKI-resistant CD44+pBAD+ blasts undergo intrinsic homeostatic adaptation to promote the survival of acute myeloid leukemia in vitro.,2023,10.3389/fonc.2023.1286863,https://pubmed.ncbi.nlm.nih.gov/38023123/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,38140685,The Identification of Host Proteins That Interact with Non-Structural Proteins-1α and -1β of Porcine Reproductive and Respiratory Syndrome Virus-1.,2023,10.3390/v15122445,https://pubmed.ncbi.nlm.nih.gov/38140685/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,33567272,Cardiolipin-mediated PPARγ S112 phosphorylation impairs IL-10 production and inflammation resolution during bacterial pneumonia.,2021,10.1016/j.celrep.2021.108736,https://pubmed.ncbi.nlm.nih.gov/33567272/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,25434787,Ubiquitously expressed transcript is a novel interacting protein of protein inhibitor of activated signal transducer and activator of transcription 2.,2015,10.3892/mmr.2014.3023,https://pubmed.ncbi.nlm.nih.gov/25434787/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,31582715,Single Nucleotide Polymorphisms of Ubiquitin-Related Genes were Associated with Allograft Fibrosis of Renal Transplant Fibrosis.,2019,10.12659/aot.917767,https://pubmed.ncbi.nlm.nih.gov/31582715/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,26403403,PAPILLARY THYROID CANCER IS CHARACTERIZED BY ALTERED EXPRESSION OF GENES INVOLVED IN THE SUMOYLATION PROCESS.,2015,,https://pubmed.ncbi.nlm.nih.gov/26403403/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,22322884,Pathway simulations in common oncogenic drivers of leukemic and rhabdomyosarcoma cells: a systems biology approach.,2012,10.3892/ijo.2012.1361,https://pubmed.ncbi.nlm.nih.gov/22322884/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,14639620,Humoral immune response against melanoma antigens induced by vaccination with cytokine gene-modified autologous tumor cells.,2004,10.1002/ijc.11537,https://pubmed.ncbi.nlm.nih.gov/14639620/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,15301740,Molecular cloning and characterization of a novel splicing variant of PIASx.,2004,,https://pubmed.ncbi.nlm.nih.gov/15301740/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,11439351,Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells.,2001,10.1038/sj.onc.1204489,https://pubmed.ncbi.nlm.nih.gov/11439351/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIAS2,ENSG00000078043,Unsafe,9920921,A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins.,1999,10.1074/jbc.274.6.3700,https://pubmed.ncbi.nlm.nih.gov/9920921/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIH1D2,ENSG00000150773,Unsafe,42837447,DNAAF19-RUVBL1/2 complex recruits multiple adaptors to promote dynein arm assembly.,2026,10.1073/pnas.2612755123,https://pubmed.ncbi.nlm.nih.gov/42837447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIH1D2,ENSG00000150773,Unsafe,41667496,An integrative structural biology approach reveals the dynamic organization of the R2SP quaternary chaperone complex.,2026,10.1038/s41467-026-69157-x,https://pubmed.ncbi.nlm.nih.gov/41667496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIH1D2,ENSG00000150773,Unsafe,41132644,Ribosome biogenesis-related gene signature predicts prognosis and immune landscape in glioma and identifies UTP20 as a therapeutic target.,2025,10.3389/fimmu.2025.1680667,https://pubmed.ncbi.nlm.nih.gov/41132644/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIH1D2,ENSG00000150773,Unsafe,39974424,Cuproptosis-related genes signature could predict prognosis and the response of immunotherapy in cervical cancer.,2025,10.21037/tcr-24-641,https://pubmed.ncbi.nlm.nih.gov/39974424/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIH1D2,ENSG00000150773,Unsafe,39857704,Genetic Nurture Effects on Type 2 Diabetes Among Chinese Han Adults: A Family-Based Design.,2025,10.3390/biomedicines13010120,https://pubmed.ncbi.nlm.nih.gov/39857704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIH1D2,ENSG00000150773,Unsafe,32251302,Transcriptomic analysis of female and male gonads in juvenile snakeskin gourami (Trichopodus pectoralis).,2020,10.1038/s41598-020-61738-0,https://pubmed.ncbi.nlm.nih.gov/32251302/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIH1D2,ENSG00000150773,Unsafe,40416607,Sialyltransferase-related genes as predictive factors for therapeutic response and prognosis in cervical cancer.,2025,10.7717/peerj.19422,https://pubmed.ncbi.nlm.nih.gov/40416607/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIH1D2,ENSG00000150773,Unsafe,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIH1D2,ENSG00000150773,Unsafe,29844425,The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones.,2018,10.1038/s41467-018-04431-1,https://pubmed.ncbi.nlm.nih.gov/29844425/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIH1D2,ENSG00000150773,Unsafe,29741156,Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly.,2018,10.7554/elife.36979,https://pubmed.ncbi.nlm.nih.gov/29741156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIH1D2,ENSG00000150773,Unsafe,33643390,Integrated Analysis of the Prognosis-Associated RNA-Binding Protein Genes and Candidate Drugs in Renal Papillary Cell Carcinoma.,2021,10.3389/fgene.2021.627508,https://pubmed.ncbi.nlm.nih.gov/33643390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIH1D2,ENSG00000150773,Unsafe,31118266,Binding properties of the quaternary assembly protein SPAG1.,2019,10.1042/bcj20190198,https://pubmed.ncbi.nlm.nih.gov/31118266/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIH1D2,ENSG00000150773,Unsafe,20310044,Novel germline SDHD deletion associated with an unusual sympathetic head and neck paraganglioma.,2011,10.1002/hed.21384,https://pubmed.ncbi.nlm.nih.gov/20310044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,42046521,"Multi-Omics and Machine Learning Analyses Reveal PIK3CG, PRKCD, and TRIM22 as Potential Markers of Poor Prognosis and Immune Activation in Glioblastoma.",2026,10.3346/jkms.2026.41.e130,https://pubmed.ncbi.nlm.nih.gov/42046521/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,41134579,PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer.,2026,10.1158/0008-5472.can-24-4501,https://pubmed.ncbi.nlm.nih.gov/41134579/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,40551174,Danshenol B alleviates central post-stroke pain by regulating the PIK3CG/NLRP3 signaling pathway.,2025,10.1186/s12967-025-06719-5,https://pubmed.ncbi.nlm.nih.gov/40551174/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,40950693,Prognostic implication of endoplasmic reticulum stress-related gene signature in lung adenocarcinoma and its effect on tumor immunity.,2025,10.21037/tcr-2024-2294,https://pubmed.ncbi.nlm.nih.gov/40950693/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,42464230,Serglycin-ROS axis mediates synergistic lethality of PI3Kγ inhibition and Azacitidine in TP53-mutated AML.,2026,10.1186/s12885-026-16547-5,https://pubmed.ncbi.nlm.nih.gov/42464230/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,41722735,Gut-brain axis-mediated mechanisms and immune regulatory pathways in vascular dementia: Insights into microbiota-derived metabolites and novel therapeutic strategies.,2026,10.1016/j.bbr.2026.116113,https://pubmed.ncbi.nlm.nih.gov/41722735/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,41539001,PIK3CG deficiency promotes metabolic reprogramming in pancreatic Cancer by suppressing GLS2-driven glutamine metabolism.,2026,10.1016/j.intimp.2025.116106,https://pubmed.ncbi.nlm.nih.gov/41539001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,41560055,Role of hsa-miR-122-5p in chronic thromboembolic pulmonary hypertension and chronic thromboembolic disease: Targeting PIK3CG in the PI3K/Akt signaling pathway.,2026,10.1097/md.0000000000047210,https://pubmed.ncbi.nlm.nih.gov/41560055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,38816660,Targeting a lineage-specific PI3Kɣ-Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule.,2024,10.1038/s43018-024-00782-5,https://pubmed.ncbi.nlm.nih.gov/38816660/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,39245801,A common variant in PIK3CG gene associated with the prognosis of heart failure.,2024,10.1111/jcmm.70069,https://pubmed.ncbi.nlm.nih.gov/39245801/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,42724825,Exploring the therapeutic potential of Astragalin in Parkinson's disease: a network pharmacology approach.,2026,10.1097/ms9.0000000000005442,https://pubmed.ncbi.nlm.nih.gov/42724825/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,40048749,Integrated analysis of DNA methylation and transcriptome profiles to identify oxidative stress-related placenta-specific molecules for preeclampsia.,2025,10.1111/jog.16209,https://pubmed.ncbi.nlm.nih.gov/40048749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,41202616,PI3K inhibitors: Efficacy in diverse cancer forms.,2025,10.1016/j.ctarc.2025.101028,https://pubmed.ncbi.nlm.nih.gov/41202616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,39603405,Protective effects of PIK3CG knockdown against OGD/R-induced neuronal damage via inhibition of autophagy through the AMPK/mTOR pathway.,2025,10.1016/j.neuroscience.2024.11.064,https://pubmed.ncbi.nlm.nih.gov/39603405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,42232567,Liubao tea as a functional fermented food: multi-omics insights into its modulation of lymphatic endothelial cell metabolism.,2026,10.3389/fnut.2026.1759992,https://pubmed.ncbi.nlm.nih.gov/42232567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,40664262,Identification of Bruceine A as a novel HSP90AB1 inhibitor for suppressing hepatocellular carcinoma growth.,2026,10.1016/j.jare.2025.07.016,https://pubmed.ncbi.nlm.nih.gov/40664262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,42228580,Multi-omics integration reveals convergent extracellular matrix remodelling and lipid metabolic reprogramming as central axes of adipocyte differentiation from mouse embryonic stem cells.,2026,10.1080/21623945.2026.2680625,https://pubmed.ncbi.nlm.nih.gov/42228580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,42011349,"Wortmannin exhibits anticancer activity in oral cancer cell line by targeting PI3K, AKT and mTOR pathway.",2026,10.22038/ajp.2025.26226,https://pubmed.ncbi.nlm.nih.gov/42011349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,39411945,"Effective Components and Molecular Mechanism of Biejiaruangan Capsule Against Liver Fibrosis: High-resolution Mass Spectrometry, Network Pharmacological Analysis and Experimental Verification.",2026,10.2174/0113862073338867240930031800,https://pubmed.ncbi.nlm.nih.gov/39411945/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,40594616,PI3K/AKT signaling pathway plays an important role in the pathogenesis of metabolic dysfunction-associated steatotic liver disease.,2025,10.1038/s41598-025-07612-3,https://pubmed.ncbi.nlm.nih.gov/40594616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,41141246,Prediction of Immunotherapy Response and Prognostic Outcomes for Patients With Ovarian Cancer Using PANoptosis-Related Genes.,2025,10.1155/humu/7108361,https://pubmed.ncbi.nlm.nih.gov/41141246/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,41732886,Evaluation of plasticizer toxicity effects and mechanisms in gastric cancer based on network toxicology and molecular docking.,2026,10.1080/01480545.2026.2633380,https://pubmed.ncbi.nlm.nih.gov/41732886/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,40419510,Integrating machine learning and multi-omics analysis to unveil key programmed cell death patterns and immunotherapy targets in kidney renal clear cell carcinoma.,2025,10.1038/s41598-025-00759-z,https://pubmed.ncbi.nlm.nih.gov/40419510/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,41216504,Novel &lt;i&gt;PIK3CG&lt;/i&gt; compound heterozygous variants cause inactivated PI3Kγ syndrome presenting as necrotizing enterocolitis in a preterm infant.,2026,10.1016/j.gendis.2025.101618,https://pubmed.ncbi.nlm.nih.gov/41216504/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,42416131,Adenosine Pathway-Based Prognostic Signature for Predicting Clinical Outcomes and Immune Microenvironment Characteristics in Epithelial Ovarian Cancer.,2026,10.14744/cpr.2026.51733,https://pubmed.ncbi.nlm.nih.gov/42416131/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,39060344,Generation of novel lipid metabolism-based signatures to predict prognosis and immunotherapy response for colorectal adenocarcinoma.,2024,10.1038/s41598-024-67549-x,https://pubmed.ncbi.nlm.nih.gov/39060344/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,42702742,"Network pharmacology, and molecular docking studies for two flavonoid compounds isolated from &lt;i&gt;Dodonaea viscosa&lt;/i&gt; towards SARS-CoV-2 infection and loaded in lipid nanoparticles.",2026,10.1080/21691401.2026.2726112,https://pubmed.ncbi.nlm.nih.gov/42702742/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,39303028,Prediction of immunotherapy response using mutations to cancer protein assemblies.,2024,10.1126/sciadv.ado9746,https://pubmed.ncbi.nlm.nih.gov/39303028/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,40331978,"A Multi-Level Study on the Anti-Lung Cancer Mechanism of Peiminine, a Key Component of &lt;i&gt;Fritillaria ussuriensis&lt;/i&gt; Maxim.: Integrating Quality Analysis, Network Pharmacology, Bioinformatics Analysis, and Experimental Validation.",2025,10.3390/ijms26083506,https://pubmed.ncbi.nlm.nih.gov/40331978/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,38296939,Bacterial protoplast-derived nanovesicles carrying CRISPR-Cas9 tools re-educate tumor-associated macrophages for enhanced cancer immunotherapy.,2024,10.1038/s41467-024-44941-9,https://pubmed.ncbi.nlm.nih.gov/38296939/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,40360577,Development and validation of a risk model for effective immune and stromal related signature predicting prognosis of patients with ovarian cancer.,2025,10.1038/s41598-025-01212-x,https://pubmed.ncbi.nlm.nih.gov/40360577/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,39154146,Chemical analogue based drug design for cancer treatment targeting PI3K: integrating machine learning and molecular modeling.,2024,10.1007/s11030-024-10966-x,https://pubmed.ncbi.nlm.nih.gov/39154146/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,40723388,Urolithin A Protects Ovarian Reserve Via Inhibiting PI3K/Akt Signaling and Preventing Chemotherapy-Induced Follicle Apoptosis.,2025,10.3390/biology14070829,https://pubmed.ncbi.nlm.nih.gov/40723388/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3CG,ENSG00000105851,Unsafe,7624799,Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase.,1995,10.1126/science.7624799,https://pubmed.ncbi.nlm.nih.gov/7624799/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,42716196,Houshiheisan modulates angiogenic responses after ischemic stroke in association with miR-126/PIK3R2 and miR-21/Hmga2/WWP1 signaling.,2026,10.1016/j.jep.2026.122371,https://pubmed.ncbi.nlm.nih.gov/42716196/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,42662823,"The lncRNA, CyKILRb acts as a ceRNA for tumor suppressive microRNA to augment oncogenic phenotype via induction of PIK3R2/PI&lt;sub&gt;3&lt;/sub&gt;K/AKT axis.",2026,10.1016/j.omtn.2026.103043,https://pubmed.ncbi.nlm.nih.gov/42662823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,42688965,"Isoform-resolved 14-3-3/YWHA networks in colorectal cancer: phospho-adaptor mechanisms, biomarker contexts and therapeutic opportunities.",2026,10.3389/fonc.2026.1906093,https://pubmed.ncbi.nlm.nih.gov/42688965/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,42873813,Endothelial-related gene expression profile of muscle adaptation to high-intensity interval training in arterial hypertension.,2026,10.1371/journal.pone.0358696,https://pubmed.ncbi.nlm.nih.gov/42873813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,42415249,A succinylation-based classifier predicts chemotherapy response in prostate cancer and reveals KAT2A as a therapeutic target.,2026,10.1002/ctm2.70737,https://pubmed.ncbi.nlm.nih.gov/42415249/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,42724360,lncRNA JPX promotes radioresistance in nasopharyngeal carcinoma via the miR-1301-3p/PIK3R2-mediated autophagy pathway.,2026,10.21037/tcr-2026-1270,https://pubmed.ncbi.nlm.nih.gov/42724360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,41566645,Macrophage-Derived Ferritin Exacerbates Silica-Induced Pulmonary Fibrosis via PIK3R2-Mediated Fibroblast Differentiation.,2026,10.1002/advs.202519191,https://pubmed.ncbi.nlm.nih.gov/41566645/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,41408025,NAT10-mediated N4-acetylcytidine (ac4C) modification of PIK3R2 mRNA promotes malignant progression of glioblastoma.,2025,10.1038/s41419-025-08328-y,https://pubmed.ncbi.nlm.nih.gov/41408025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,41982962,Megalencephaly-polymicrogyria-polydactyly-hydrocephalus (MPPH) syndrome with aplasia cutis congenita due to PIK3R2 mutations: case report.,2026,10.21037/tp-2025-aw-698,https://pubmed.ncbi.nlm.nih.gov/41982962/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,42829067,Targeting the metabolic-immune regulator SLC35F6 enhances temozolomide and anti-PD-L1 therapy in glioma.,2026,10.1016/j.canlet.2026.218867,https://pubmed.ncbi.nlm.nih.gov/42829067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,42323969,Histone lactylation at H4K12 promotes macrophage-fibroblast crosstalk in neodymium oxide-induced pulmonary fibrosis via the PIK3R2/PI3K/Akt/mTOR axis.,2026,10.1016/j.cbi.2026.112216,https://pubmed.ncbi.nlm.nih.gov/42323969/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,42514681,Transcriptomic Analysis Reveals AKT1 Upregulation in Inner Mongolian Cashmere Goats at 12 and 15 Months of Age.,2026,10.3390/vetsci13070671,https://pubmed.ncbi.nlm.nih.gov/42514681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,40725119,Characterization of DNA Methylation Episignatures for Radon-Induced Lung Cancer.,2025,10.3390/ijms26146873,https://pubmed.ncbi.nlm.nih.gov/40725119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,42026874,ISG15 Mediates Oxidative Stress Modulation in T2DM Patients by Directly Targeting PIK3R2.,2026,10.1002/biof.70103,https://pubmed.ncbi.nlm.nih.gov/42026874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,41633200,ERβ-PIK3R2 axis promotes estrogen-driven gastric cancer progression.,2026,10.1016/j.bbrc.2026.153271,https://pubmed.ncbi.nlm.nih.gov/41633200/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,41510934,Effect of miR-1 and miR-126-5p in BCL2 and PIK3R2 regulation in apoptotic signaling during ST-elevation myocardial infarction.,2026,10.15586/aei.v54i1.1520,https://pubmed.ncbi.nlm.nih.gov/41510934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,40504311,PIK3R2 immunostaining status predicts prognosis in patients with newly diagnosed glioblastoma treated with an autologous tumor vaccine.,2025,10.1007/s11060-025-05102-0,https://pubmed.ncbi.nlm.nih.gov/40504311/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,42584803,Identification and Validation of programmed cell death-related biomarkers in Osteoarthritis and an Exploratory Pan-Cancer Analysis: SHARPIN as a Potential Biomarker.,2026,10.1007/s10067-026-08320-7,https://pubmed.ncbi.nlm.nih.gov/42584803/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,39402462,Ethoxy-erianin phosphate inhibits angiogenesis in colorectal cancer by regulating the TMPO-AS1/miR-126-3p/PIK3R2 axis and inactivating the PI3k/AKT signaling pathway.,2024,10.1186/s12885-024-12893-4,https://pubmed.ncbi.nlm.nih.gov/39402462/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,38317714,Divergent roles of the regulatory subunits of class IA PI3K.,2023,10.3389/fendo.2023.1152579,https://pubmed.ncbi.nlm.nih.gov/38317714/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,40924331,Correction to: PIK3R2 immunostaining status predicts prognosis in patients with newly diagnosed glioblastoma treated with an autologous tumor vaccine.,2025,10.1007/s11060-025-05203-w,https://pubmed.ncbi.nlm.nih.gov/40924331/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,40553443,"Novel Small-Molecule miR-124 Inducer Acts as ""a Physiological Brake"" of Inflammation in Ulcerative Colitis by Targeting the PIK3R2/PI3K/Akt Axis.",2025,10.1021/acs.jmedchem.5c01398,https://pubmed.ncbi.nlm.nih.gov/40553443/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,40473165,YTHDF2 phase separation promotes arsenite-induced oxidative stress by facilitating YTHDF2-mediated PIK3R2 mRNA degradation.,2025,10.1016/j.ijbiomac.2025.144936,https://pubmed.ncbi.nlm.nih.gov/40473165/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,41516156,"Molecular Crosstalk Between Intrauterine hCG and Endometrial Receptivity: Signalling Pathways, Immune Modulation, and Translational Perspectives in IVF.",2025,10.3390/ijms27010278,https://pubmed.ncbi.nlm.nih.gov/41516156/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,42305434,Bruceine D attenuates prostate cancer growth and motility by suppressing PI3K/AKT signaling and downregulating CXCL16: implications for skeletal metastasis in orthopedic oncology.,2026,10.3389/fphar.2026.1819854,https://pubmed.ncbi.nlm.nih.gov/42305434/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,42604788,mi-RNA-mRNA Alterations in Sorted T-Cells of Acquired Aplastic Anemia: Validating the Observations of a Pilot Study.,2026,10.1111/ijlh.70224,https://pubmed.ncbi.nlm.nih.gov/42604788/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,39835132,Integrating bioinformatics and machine learning to identify AhR-related gene signatures for prognosis and tumor microenvironment modulation in melanoma.,2024,10.3389/fimmu.2024.1519345,https://pubmed.ncbi.nlm.nih.gov/39835132/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,41882062,Transcriptome and resequencing reveal immune-related genes and molecular markers associated with Aeromonas salmonicida resistance in Salmo trutta fario.,2026,10.1038/s41598-026-45045-8,https://pubmed.ncbi.nlm.nih.gov/41882062/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,41961389,"Network pharmacology, molecular docking, and In Vitro evaluation of morin against gastric cancer.",2026,10.1007/s11030-026-11535-0,https://pubmed.ncbi.nlm.nih.gov/41961389/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,38638737,Transcriptome-Based Treatment for Melanoma With Brain Metastasis: A Case Report.,2024,10.7759/cureus.56494,https://pubmed.ncbi.nlm.nih.gov/38638737/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,40733070,Molecular Target Identification of Gossypol Against Cervical Cancer Based on Target Fishing Technology.,2025,10.3390/pharmaceutics17070861,https://pubmed.ncbi.nlm.nih.gov/40733070/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,42109608,Defining PI3K Signaling as a Key Regulator of Molecular Heterogeneity and Inflammation in Glomerular Lupus Nephritis.,2026,10.4110/in.2026.26.e2,https://pubmed.ncbi.nlm.nih.gov/42109608/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,41168318,CTTN overexpression in HNSCC inhibits Anoikis-apoptosis.,2025,10.1038/s41598-025-21891-w,https://pubmed.ncbi.nlm.nih.gov/41168318/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,40303918,"YX-112, a novel celastrol-derived PROTAC, inhibits the development of triple-negative breast cancer by targeting the degradation of multiple proteins.",2025,10.3389/fphar.2025.1571135,https://pubmed.ncbi.nlm.nih.gov/40303918/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R2,ENSG00000105647,Unsafe,37989822,Anoikis patterns via machine learning strategy and experimental verification exhibit distinct prognostic and immune landscapes in melanoma.,2024,10.1007/s12094-023-03336-w,https://pubmed.ncbi.nlm.nih.gov/37989822/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,42840318,A Regulator SNP Affecting the Transcription Factor &lt;i&gt;SP1&lt;/i&gt; Binding Site in the &lt;i&gt;PIK3R3&lt;/i&gt; Gene Contributes to Noise-Induced Hearing Loss Risk.,2026,10.1155/humu/7010704,https://pubmed.ncbi.nlm.nih.gov/42840318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,41889636,"Exploring hub genes related to adipocytokines in keloids: a combined analysis integrating single-cell, Mendelian randomization and bulk transcriptome data with experimental verification.",2026,10.3389/fmolb.2026.1740876,https://pubmed.ncbi.nlm.nih.gov/41889636/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,42731765,Genome-wide CRISPRi screen in human iNeurons identifies novel negative mTOR regulator genes associated with focal cortical dysplasia.,2026,10.1016/j.nbd.2026.107602,https://pubmed.ncbi.nlm.nih.gov/42731765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,42890566,Integrated transcriptome and single-cell RNA sequencing identifies transient receptor potential channel-related biomarkers in ulcerative colitis.,2026,10.3389/fmolb.2026.1902447,https://pubmed.ncbi.nlm.nih.gov/42890566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,42483220,Systematic pan-cancer analysis identifies PIK3R3 as a lipid metabolism and immune regulation prognostic biomarker.,2026,10.1515/med-2026-1439,https://pubmed.ncbi.nlm.nih.gov/42483220/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,41218910,miR-432 Exacerbates Obesity-Induced Dysregulation of Glucose and Lipid Homeostasis.,2026,10.2337/db25-0295,https://pubmed.ncbi.nlm.nih.gov/41218910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,41664201,Unraveling the role of lipid metabolism in polycystic ovary syndrome through multi-omics Mendelian randomization.,2026,10.1186/s13048-026-02014-z,https://pubmed.ncbi.nlm.nih.gov/41664201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,42613707,Transcriptomic Profiling Identifies MyD88 and Pik3r3 as Hub Genes Associated with the Anti-hypertrophic Effects of B-type Natriuretic Peptide.,2026,10.2174/0113894501500225260727072404,https://pubmed.ncbi.nlm.nih.gov/42613707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,42873880,Vitamin D binding protein in ventral CA3 of the hippocampus drives stress-induced depression.,2026,10.1126/sciadv.aeh9563,https://pubmed.ncbi.nlm.nih.gov/42873880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,39862908,PIK3R3 regulates differentiation and senescence of periodontal ligament stem cells and mitigates age-related alveolar bone loss by modulating FOXO1 expression.,2025,10.1016/j.jare.2025.01.031,https://pubmed.ncbi.nlm.nih.gov/39862908/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,41444310,Decoding molecular signatures and identifying therapeutic targets in triple-negative breast cancer subtypes using omics and network analysis.,2025,10.1038/s41598-025-28191-3,https://pubmed.ncbi.nlm.nih.gov/41444310/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,40906280,Prognostic Value of MCM3AP-AS1 in Glioma and its Regulatory Effect on Tumor Progression.,2025,10.1007/s11064-025-04539-z,https://pubmed.ncbi.nlm.nih.gov/40906280/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,41210966,Transcriptomic profiling of endothelial progenitor cells in post-COVID-19 patients: Insights at 3 and 6-month post-infection.,2025,10.1016/j.isci.2025.113731,https://pubmed.ncbi.nlm.nih.gov/41210966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,39183556,POU2F1 inhibits miR-29b1/a cluster-mediated suppression of PIK3R1 and PIK3R3 expression to regulate gastric cancer cell invasion and migration.,2025,10.1097/cm9.0000000000003181,https://pubmed.ncbi.nlm.nih.gov/39183556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,38618952,Von Hippel Lindau tumor suppressor controls m6A-dependent gene expression in renal tumorigenesis.,2024,10.1172/jci175703,https://pubmed.ncbi.nlm.nih.gov/38618952/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,38952574,Engineered CARD11-PIK3R3 T-cell therapies as weapons of cancer mass destruction.,2024,10.1002/mco2.628,https://pubmed.ncbi.nlm.nih.gov/38952574/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,39466763,ZSTK474 targeting PIK3R3 inhibits the Wilms' tumor through G0 / G1 phase arrest.,2024,10.1371/journal.pone.0312178,https://pubmed.ncbi.nlm.nih.gov/39466763/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,40594616,PI3K/AKT signaling pathway plays an important role in the pathogenesis of metabolic dysfunction-associated steatotic liver disease.,2025,10.1038/s41598-025-07612-3,https://pubmed.ncbi.nlm.nih.gov/40594616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,41514467,Multi-omics profiling of chromatin accessibility and H3K27ac reveals super-enhancer-mediated regulatory networks governing endometrial receptivity in goats.,2026,10.1186/s40104-025-01318-2,https://pubmed.ncbi.nlm.nih.gov/41514467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,41570977,Integrative functional genomics and fine-mapping identify regulatory mechanisms of multivariate obesity GWAS and its cardiometabolic implications.,2026,10.1016/j.metabol.2026.156509,https://pubmed.ncbi.nlm.nih.gov/41570977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,38730483,Unveiling a novel fusion gene enhances CAR T cell therapy for solid tumors.,2024,10.1186/s12943-024-02007-w,https://pubmed.ncbi.nlm.nih.gov/38730483/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,38326614,Naturally occurring T cell mutations enhance engineered T cell therapies.,2024,10.1038/s41586-024-07018-7,https://pubmed.ncbi.nlm.nih.gov/38326614/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,41272036,A SWI/SNF complex-related genes signature predicts prognosis and immune infiltration in ccRCC with KCNK5 as a novel biomarker.,2025,10.1038/s41598-025-25283-y,https://pubmed.ncbi.nlm.nih.gov/41272036/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,40384613,Investigating Overlapping Immune-related Genetic Markers in Cholangiocarcinoma and Inflammatory Bowel Disease for Predictive Prognosis.,2025,10.1097/cji.0000000000000562,https://pubmed.ncbi.nlm.nih.gov/40384613/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,41961389,"Network pharmacology, molecular docking, and In Vitro evaluation of morin against gastric cancer.",2026,10.1007/s11030-026-11535-0,https://pubmed.ncbi.nlm.nih.gov/41961389/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,41355178,Developing a Radiotherapy and Immune-Related Genes-Based Prognostic Model to Predict Prognosis and Immune Microenvironment in Thyroid Cancer.,2026,10.1002/bab.70092,https://pubmed.ncbi.nlm.nih.gov/41355178/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,38568409,Effects of Mesenchymal Stem Cells-Derived Extracellular Vesicles on Inhibition of Hepatic Fibrosis by Delivering miR-200a.,2024,10.1007/s13770-024-00631-7,https://pubmed.ncbi.nlm.nih.gov/38568409/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,38688945,Characterization of macrophages in head and neck squamous cell carcinoma and development of MRG-based risk signature.,2024,10.1038/s41598-024-60516-6,https://pubmed.ncbi.nlm.nih.gov/38688945/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,41170188,Impact of trehalose and hydroxychloroquine on the function of BRAF (V600E)-siRNA in the A375 melanoma cells.,2025,10.22038/ijbms.2025.85017.18394,https://pubmed.ncbi.nlm.nih.gov/41170188/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,40343301,"Investigating therapeutic efficacy of dacarbazine and temozolomide, alone and in combination with &lt;i&gt;BRAF&lt;/i&gt; &lt;sup&gt;(V600E)&lt;/sup&gt; siRNA in A375 human melanoma cell line.",2025,10.22038/ijbms.2025.84187.18208,https://pubmed.ncbi.nlm.nih.gov/40343301/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,37430199,Identification of key genes and the pathophysiology associated with allergen-specific immunotherapy for allergic rhinitis.,2023,10.1186/s12865-023-00556-1,https://pubmed.ncbi.nlm.nih.gov/37430199/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,41219646,Molecular mechanisms and genetic predisposition to osteoarthritis and osteosarcoma through Mendelian inheritance patterns.,2025,10.1007/s12672-025-03917-x,https://pubmed.ncbi.nlm.nih.gov/41219646/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIK3R3,ENSG00000117461,Unsafe,38730286,Choline metabolism reprogramming mediates an immunosuppressive microenvironment in non-small cell lung cancer (NSCLC) by promoting tumor-associated macrophage functional polarization and endothelial cell proliferation.,2024,10.1186/s12967-024-05242-3,https://pubmed.ncbi.nlm.nih.gov/38730286/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,42625859,"Dysregulation of piRNA biogenesis-associated proteins in cancer: mechanisms, evidence, and translational constraints.",2026,10.3389/fmolb.2026.1906635,https://pubmed.ncbi.nlm.nih.gov/42625859/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,42053851,Effects of 17β-estradiol interference on the temporal and spatial expression patterns of piwil1 gene and gonadal development in largemouth bass (Micropterus salmoides).,2026,10.1007/s10695-026-01686-0,https://pubmed.ncbi.nlm.nih.gov/42053851/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,41706354,A homozygous PIWIL1 frameshift variant triggers azoospermia and reveals a strong selective constraint on germline genome integrity.,2026,10.1007/s10815-026-03826-0,https://pubmed.ncbi.nlm.nih.gov/41706354/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,42022287,Emerging roles of PIWI-interacting RNAs in cancer molecular diagnostics and therapeutics: a molecular biosciences perspective.,2026,10.3389/fmolb.2026.1775335,https://pubmed.ncbi.nlm.nih.gov/42022287/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,41596471,"P-Element-Induced Wimpy Testis (PIWI)-Interacting RNA-823/PIWIL1/DNMT3B/CDH1 as Potential Axis to Drive EMT, Stemness, and Tumor Aggressiveness in Ovarian Cancer Tissue Samples: An Integrative Computational and Clinical Insights.",2026,10.3390/ijms27020823,https://pubmed.ncbi.nlm.nih.gov/41596471/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,42555113,Dynamic protein expression in golden hamster oocytes and embryos reveals extensive post-translational regulation of PIWIL1 during the oocyte-to-embryo transition†.,2026,10.1093/biolre/ioag167,https://pubmed.ncbi.nlm.nih.gov/42555113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,40705004,Meioc-Piwil1 complexes regulate rRNA transcription for differentiation of spermatogonial stem cells.,2025,10.7554/elife.104295,https://pubmed.ncbi.nlm.nih.gov/40705004/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,42402549,Inverse co-variation of circulating PIWIL2 and PIWIL4 in gastric adenocarcinoma: an exploratory ELISA-based study.,2026,10.1186/s12014-026-09621-4,https://pubmed.ncbi.nlm.nih.gov/42402549/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,42106149,Noncanonical Transcription and Splicing Shape the Colorectal Cancer Immunopeptidome in MSI and MSS Tumors.,2026,10.1016/j.mcpro.2026.101581,https://pubmed.ncbi.nlm.nih.gov/42106149/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,42621097,PIWIL2 drives stroke progression via modulation of NF-κB signaling.,2026,10.1016/j.omtn.2026.103037,https://pubmed.ncbi.nlm.nih.gov/42621097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,41894395,Non-gonadal PIWIL1/Aubergine drives regenerative and tumorigenic stem cell proliferation and tumorigenesis in the intestine.,2026,10.1016/j.celrep.2026.117186,https://pubmed.ncbi.nlm.nih.gov/41894395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,42020726,PIWIL1 activates the R2TP-TELO2-mTORC1 axis independently of piRNA to promote TOP mRNA translation in gastric cancer.,2026,10.1038/s41388-026-03791-z,https://pubmed.ncbi.nlm.nih.gov/42020726/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,39397093,PIWIL1 is recruited to centrosomes during mitosis in colorectal cancer cells and is linked to cell cycle progression.,2024,10.1038/s41598-024-75098-6,https://pubmed.ncbi.nlm.nih.gov/39397093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,40975746,Male specific conserved LncRNA TSCL1 regulated target mRNA translation by interaction with PIWIL1.,2026,10.1038/s41418-025-01583-8,https://pubmed.ncbi.nlm.nih.gov/40975746/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,39696987,CARF regulates the alternative splicing and piwi/piRNA complexes during mouse spermatogenesis through PABPC1.,2024,10.3724/abbs.2024224,https://pubmed.ncbi.nlm.nih.gov/39696987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,40944384,"Altered Hippocampal Transcriptomic Profile Reveals Cognitive Impairment in Young Metabolically Obese, Normal-Weight Rats, Prevented by Perinatal Leptin Intake.",2025,10.1002/mnfr.70262,https://pubmed.ncbi.nlm.nih.gov/40944384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,42622507,"Spastic and non-spastic spinal cord injury induce systemic reproductive impairment via alterations in testicular morphology, microenvironment, spermatogenesis, and modulation of sperm parameters.",2026,10.1080/10790268.2026.2709255,https://pubmed.ncbi.nlm.nih.gov/42622507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,42409137,Estrogen signaling counteracts androgen/Ar-mediated suppression of foxl2 expression and ovarian differentiation during sexual fate determination in zebrafish.,2026,10.1016/j.ygcen.2026.114977,https://pubmed.ncbi.nlm.nih.gov/42409137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,37298298,cDNA Cloning of Feline PIWIL1 and Evaluation of Expression in the Testis of the Domestic Cat.,2023,10.3390/ijms24119346,https://pubmed.ncbi.nlm.nih.gov/37298298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,38892123,DNA Methylation Mediates Sperm Quality via piwil1 and piwil2 Regulation in Japanese Flounder (Paralichthys olivaceus).,2024,10.3390/ijms25115935,https://pubmed.ncbi.nlm.nih.gov/38892123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,40301858,Integration of multi-omics data to unveil the molecular landscape and role of piRNAs in early-onset colorectal cancer.,2025,10.1186/s12916-025-04074-2,https://pubmed.ncbi.nlm.nih.gov/40301858/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,40729068,"Decreased Expression Levels Of PIWIL2, PIWIL3 and PIWIL4 Are Associated with Poor Prognosis and Worse Survival in Bladder Cancer Patients.",2025,10.31557/apjcp.2025.26.7.2467,https://pubmed.ncbi.nlm.nih.gov/40729068/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,38036929,HPV16 E6/E7-mediated regulation of PiwiL1 expression induces tumorigenesis in cervical cancer cells.,2024,10.1007/s13402-023-00904-8,https://pubmed.ncbi.nlm.nih.gov/38036929/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,41619307,Biosynthesis of Silver Nanoparticles Using Black Pepper (Piper nigrum) Seed Extract and Evaluation of Their Cytotoxicity.,2026,10.1002/cbdv.202503359,https://pubmed.ncbi.nlm.nih.gov/41619307/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,37835834,Characterization of Cancer/Testis Antigens as Prognostic Markers of Ovarian Cancer.,2023,10.3390/diagnostics13193092,https://pubmed.ncbi.nlm.nih.gov/37835834/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,38171105,Alleviative effect of quercetin against reproductive toxicity induced by chronic exposure to the mixture of phthalates in male rats.,2024,10.1016/j.ecoenv.2023.115920,https://pubmed.ncbi.nlm.nih.gov/38171105/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,39604866,PIWIL genes in hepatocellular carcinoma: a multi-omics approach uncovering dysregulated expression and ceRNA networks in mice.,2024,10.1186/s12863-024-01283-1,https://pubmed.ncbi.nlm.nih.gov/39604866/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,38023199,PIWIL1 gene polymorphism and pediatric acute lymphoblastic leukemia relapse susceptibility among Chinese children: a five-center case-control study.,2023,10.3389/fonc.2023.1203002,https://pubmed.ncbi.nlm.nih.gov/38023199/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,38218207,Long-term exposure to the mixture of phthalates induced male reproductive toxicity in rats and the alleviative effects of quercetin.,2024,10.1016/j.taap.2024.116816,https://pubmed.ncbi.nlm.nih.gov/38218207/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,33633112,PIWIL1 governs the crosstalk of cancer cell metabolism and immunosuppressive microenvironment in hepatocellular carcinoma.,2021,10.1038/s41392-021-00485-8,https://pubmed.ncbi.nlm.nih.gov/33633112/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,38440903,Ameliorative effects of zinc and vitamin E against phthalates-induced reproductive toxicity in male rats.,2024,10.1002/tox.24191,https://pubmed.ncbi.nlm.nih.gov/38440903/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,35464758,Novel piRNA Regulates PIWIL1 to Modulate the Behavior of Placental Trophoblast Cells and Participates in Preeclampsia.,2022,10.1155/2022/7856290,https://pubmed.ncbi.nlm.nih.gov/35464758/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,35083142,PIWIL1 Drives Chemoresistance in Multiple Myeloma by Modulating Mitophagy and the Myeloma Stem Cell Population.,2021,10.3389/fonc.2021.783583,https://pubmed.ncbi.nlm.nih.gov/35083142/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,23436708,Scanning of novel cancer/testis proteins by human testis proteomic analysis.,2013,10.1002/pmic.201200489,https://pubmed.ncbi.nlm.nih.gov/23436708/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,12906857,Identification of eight members of the Argonaute family in the human genome.,2003,10.1016/s0888-7543(03)00129-0,https://pubmed.ncbi.nlm.nih.gov/12906857/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,12037681,"Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas.",2002,10.1038/sj.onc.1205505,https://pubmed.ncbi.nlm.nih.gov/12037681/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL1,ENSG00000125207,Unsafe,11154219,"Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi.",2001,10.1182/blood.v97.2.426,https://pubmed.ncbi.nlm.nih.gov/11154219/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,42621097,PIWIL2 drives stroke progression via modulation of NF-κB signaling.,2026,10.1016/j.omtn.2026.103037,https://pubmed.ncbi.nlm.nih.gov/42621097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,42625859,"Dysregulation of piRNA biogenesis-associated proteins in cancer: mechanisms, evidence, and translational constraints.",2026,10.3389/fmolb.2026.1906635,https://pubmed.ncbi.nlm.nih.gov/42625859/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,42776838,piRNA-mediated silencing of exogenous retrovirus in mouse spermatogonial stem cells.,2026,10.1016/j.celrep.2026.117992,https://pubmed.ncbi.nlm.nih.gov/42776838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,41240179,A short PIWIL2 isoform PL2L60A induces functional and transcriptional changes indicative of a procancerous phenotype.,2025,10.1007/s11033-025-11259-8,https://pubmed.ncbi.nlm.nih.gov/41240179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,42402549,Inverse co-variation of circulating PIWIL2 and PIWIL4 in gastric adenocarcinoma: an exploratory ELISA-based study.,2026,10.1186/s12014-026-09621-4,https://pubmed.ncbi.nlm.nih.gov/42402549/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,41422314,Peptide‑based therapeutics targeting the SLC39A14‑PIWIL2 fusion in hepatocellular carcinoma.,2025,10.1186/s44342-025-00060-5,https://pubmed.ncbi.nlm.nih.gov/41422314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,42899482,Tumour Antigen-Specific Antibody Signatures as Diagnostic Biomarkers for Melanoma.,2026,10.1002/ijc.70726,https://pubmed.ncbi.nlm.nih.gov/42899482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,41311252,Cardiac Myofibroblast-Derived Small Extracellular Vesicles Moderate Fibrotic Responses via piRNA-62788/PIWIL2-Mediated SRF Silencing.,2025,10.1002/jev2.70204,https://pubmed.ncbi.nlm.nih.gov/41311252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,42123708,A Post-GWAS Analysis of the Shared Genetic Architecture Between COVID-19 and Coronary Artery Disease.,2026,10.3390/ijms27094132,https://pubmed.ncbi.nlm.nih.gov/42123708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,41023308,PIWI proteins tether the piRNA biogenesis machinery to mitochondria during mammalian spermatogenesis.,2025,10.1038/s44318-025-00579-x,https://pubmed.ncbi.nlm.nih.gov/41023308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,42529606,Ashwagandha-Induced Herb-Induced Liver Injury Assessed With the Updated 2016 RUCAM.,2026,10.1155/crhe/8417352,https://pubmed.ncbi.nlm.nih.gov/42529606/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,40789164,PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypes.,2025,10.1242/bio.061942,https://pubmed.ncbi.nlm.nih.gov/40789164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,40729068,"Decreased Expression Levels Of PIWIL2, PIWIL3 and PIWIL4 Are Associated with Poor Prognosis and Worse Survival in Bladder Cancer Patients.",2025,10.31557/apjcp.2025.26.7.2467,https://pubmed.ncbi.nlm.nih.gov/40729068/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,41514836,"Comparative RNA-Seq Analysis of Differentially Expressed Genes in the Testis and Ovary of Mudskipper, &lt;i&gt;Boleophthalmus pectinirostris&lt;/i&gt;.",2026,10.3390/ani16010150,https://pubmed.ncbi.nlm.nih.gov/41514836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,41280641,Inhibition of BRD4 activates the AKT-SIRT3 signaling pathway to suppress apoptosis and attenuate hyperoxia-induced lung injury.,2025,10.3389/fbioe.2025.1674916,https://pubmed.ncbi.nlm.nih.gov/41280641/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,38918675,HEPPAR1 and PIWIL2 as Panel Markers for Hepatocellular Carcinoma.,2024,10.31557/apjcp.2024.25.6.2123,https://pubmed.ncbi.nlm.nih.gov/38918675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,38892123,DNA Methylation Mediates Sperm Quality via piwil1 and piwil2 Regulation in Japanese Flounder (Paralichthys olivaceus).,2024,10.3390/ijms25115935,https://pubmed.ncbi.nlm.nih.gov/38892123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,41523260,Erratum: The role of Nrf2/PIWIL2/purine metabolism axis in controlling radiation-induced lung fibrosis.,2025,10.62347/irbu1929,https://pubmed.ncbi.nlm.nih.gov/41523260/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,42491527,Liver Injury Associated With Irregular Herbal Products: A Translational Case Series With Chemical Authentication and Causality Assessment Using the Updated RUCAM.,2026,10.1155/crhe/5905774,https://pubmed.ncbi.nlm.nih.gov/42491527/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,41477654,Kava Herb-Induced Liver Injury as Verified by the Updated RUCAM.,2025,10.1155/crgm/3914876,https://pubmed.ncbi.nlm.nih.gov/41477654/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,42772543,Herb-induced liver injury: An immunological perspective.,2026,10.1016/j.tox.2026.154594,https://pubmed.ncbi.nlm.nih.gov/42772543/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,41380411,"A comprehensive review of herb-induced liver injury: Mechanisms, clinical management, and future perspectives in natural product safety.",2026,10.1016/j.phymed.2025.157647,https://pubmed.ncbi.nlm.nih.gov/41380411/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,42425000,3D-printed MOF-hydrogel microarray for multiplexed miRNA detection and early herb-induced liver injury warning.,2026,10.1016/j.bios.2026.119000,https://pubmed.ncbi.nlm.nih.gov/42425000/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,41700226,Herb-Induced Liver Injury (HILI) Associated With Asowosi (Momordica charantia): A Case Report.,2026,10.7759/cureus.101682,https://pubmed.ncbi.nlm.nih.gov/41700226/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,42665171,ABCB1 rs2032582 as a potential biomarker for predicting Scutellaria baicalensis Georgi-drug induced liver injury in humans.,2026,10.1016/j.jep.2026.122329,https://pubmed.ncbi.nlm.nih.gov/42665171/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,41205638,Factors influencing severity and various clinical indexes in herb-induced liver injury: An updated bibliometric analysis and meta-analysis.,2026,10.1016/j.jep.2025.120864,https://pubmed.ncbi.nlm.nih.gov/41205638/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,42512832,"Etiology-Based Comparative Evaluation of Toxic Hepatitis in a Tertiary Referral Cohort: Drug-Induced, Herb-Induced, Mushroom Poisoning, and Other Toxic Exposures.",2026,10.3390/medicina62071290,https://pubmed.ncbi.nlm.nih.gov/42512832/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,42326995,Relative effects of interval training with different intensities and interval structures on cardiometabolic health indicators in sedentary young males: a randomized controlled trial.,2026,10.3389/fphys.2026.1842740,https://pubmed.ncbi.nlm.nih.gov/42326995/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,41158894,Probable Cinnamon-Induced Mixed Hepatocellular-Cholestatic Liver Injury in a Young Woman: A Case Report.,2025,10.7759/cureus.93328,https://pubmed.ncbi.nlm.nih.gov/41158894/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,41683390,Hepatic Sinusoidal Obstruction Syndrome Induced by Pyrrolizidine Alkaloids from &lt;i&gt;Gynura segetum&lt;/i&gt;: Mechanisms and Therapeutic Advances.,2026,10.3390/molecules31030410,https://pubmed.ncbi.nlm.nih.gov/41683390/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,41455671,Safety of herbal medicines in Korean medicine clinics in Republic of Korea: A nationwide retrospective longitudinal cohort study.,2026,10.1016/j.joim.2025.12.001,https://pubmed.ncbi.nlm.nih.gov/41455671/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,39057089,Phytotherapy-Induced Hepatocytotoxicity: A Case Report.,2024,10.3390/cimb46070448,https://pubmed.ncbi.nlm.nih.gov/39057089/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,39079402,Insights gained into the injury mechanism of drug and herb induced liver injury in the hepatic microenvironment.,2024,10.1016/j.tox.2024.153900,https://pubmed.ncbi.nlm.nih.gov/39079402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,39136211,Challenges in herbal-induced liver injury identification and prevention.,2025,10.1111/liv.16071,https://pubmed.ncbi.nlm.nih.gov/39136211/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PIWIL2,ENSG00000197181,Unsafe,16377660,Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway.,2006,10.1093/hmg/ddi430,https://pubmed.ncbi.nlm.nih.gov/16377660/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,39230647,Splice-altering variant of PJVK gene in a Mauritanian family with non-syndromic hearing impairment.,2025,10.1007/s13353-024-00903-x,https://pubmed.ncbi.nlm.nih.gov/39230647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,42184971,Phylogenomic analysis of vocal fold length evolution reveals links between vocal and auditory systems in terrestrial mammals.,2026,10.1093/molbev/msag126,https://pubmed.ncbi.nlm.nih.gov/42184971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,38249806,"GSDMB: A novel, independent prognostic marker and potential new therapeutic target in clear cell renal cell carcinoma.",2024,10.3892/ol.2024.14219,https://pubmed.ncbi.nlm.nih.gov/38249806/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,35052489,"Novel Pathogenic Variants in PJVK, the Gene Encoding Pejvakin, in Subjects with Autosomal Recessive Non-Syndromic Hearing Impairment and Auditory Neuropathy Spectrum Disorder.",2022,10.3390/genes13010149,https://pubmed.ncbi.nlm.nih.gov/35052489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,36632024,"Pyroptosis, inflammasome, and gasdermins in tumor immunity.",2023,10.1177/17534259221143216,https://pubmed.ncbi.nlm.nih.gov/36632024/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,38225586,Pyroptosis: a double-edged sword in lung cancer and other respiratory diseases.,2024,10.1186/s12964-023-01458-w,https://pubmed.ncbi.nlm.nih.gov/38225586/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,39807507,Comprehensive analyses reveal the promising value of gasdermins as prognostic biomarkers and immunotherapeutic targets in head and neck squamous cell carcinoma.,2025,10.1016/j.heliyon.2024.e41213,https://pubmed.ncbi.nlm.nih.gov/39807507/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,36505798,Prognostic value and immune infiltration of the gasdermin family in lung adenocarcinoma.,2022,10.3389/fonc.2022.1043862,https://pubmed.ncbi.nlm.nih.gov/36505798/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,32917362,Generation and pathological characterization of a transgenic mouse model carrying a missense PJVK mutation.,2020,10.1016/j.bbrc.2020.07.101,https://pubmed.ncbi.nlm.nih.gov/32917362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,39663698,Whole-exome sequencing reveals known and candidate genes for hearing impairment in Mali.,2025,10.1016/j.xhgg.2024.100391,https://pubmed.ncbi.nlm.nih.gov/39663698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,36278489,Gene therapy with a synthetic adeno-associated viral vector improves audiovestibular phenotypes in Pjvk-mutant mice.,2022,10.1172/jci.insight.152941,https://pubmed.ncbi.nlm.nih.gov/36278489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,34091823,"Differential Expression and Copy Number Variation of Gasdermin (GSDM) Family Members, Pore-Forming Proteins in Pyroptosis, in Normal and Malignant Serous Ovarian Tissue.",2021,10.1007/s10753-021-01493-0,https://pubmed.ncbi.nlm.nih.gov/34091823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,28209736,"Pejvakin, a Candidate Stereociliary Rootlet Protein, Regulates Hair Cell Function in a Cell-Autonomous Manner.",2017,10.1523/jneurosci.2711-16.2017,https://pubmed.ncbi.nlm.nih.gov/28209736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,32294153,Gasdermins: pore-forming activities and beyond.,2020,10.1093/abbs/gmaa016,https://pubmed.ncbi.nlm.nih.gov/32294153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,35116710,A pan-cancer analysis of the expression of gasdermin genes in tumors and their relationship with the immune microenvironment.,2021,10.21037/tcr-21-1635,https://pubmed.ncbi.nlm.nih.gov/35116710/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,39655096,Efficiency of gene therapy for sensorineural hearing loss in mouse model: A meta-analysis.,2024,10.1002/lio2.70048,https://pubmed.ncbi.nlm.nih.gov/39655096/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,36189207,"Pyroptosis in development, inflammation and disease.",2022,10.3389/fimmu.2022.991044,https://pubmed.ncbi.nlm.nih.gov/36189207/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,38232665,To die or not to die: Gasdermins in intestinal health and disease.,2024,10.1016/j.smim.2024.101865,https://pubmed.ncbi.nlm.nih.gov/38232665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,35321945,GSDMs are potential therapeutic targets and prognostic biomarkers in clear cell renal cell carcinoma.,2022,10.18632/aging.203973,https://pubmed.ncbi.nlm.nih.gov/35321945/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,28089576,Conditional deletion of pejvakin in adult outer hair cells causes progressive hearing loss in mice.,2017,10.1016/j.neuroscience.2016.12.055,https://pubmed.ncbi.nlm.nih.gov/28089576/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,39456947,The Evolution of NLR Inflammasome and Its Mediated Pyroptosis in Metazoa.,2024,10.3390/ijms252011167,https://pubmed.ncbi.nlm.nih.gov/39456947/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,35463276,Comprehensive Bioinformatics Analysis of Gasdermin Family of Glioma.,2022,10.1155/2022/9046507,https://pubmed.ncbi.nlm.nih.gov/35463276/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,37143720,Identification of bicalutamide resistance-related genes and prognosis prediction in patients with prostate cancer.,2023,10.3389/fendo.2023.1125299,https://pubmed.ncbi.nlm.nih.gov/37143720/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,33634141,Biological Functions of Gasdermins in Cancer: From Molecular Mechanisms to Therapeutic Potential.,2021,10.3389/fcell.2021.638710,https://pubmed.ncbi.nlm.nih.gov/33634141/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,35836259,Prognostic prediction of systemic immune-inflammation status for patients with colorectal cancer: a novel pyroptosis-related model.,2022,10.1186/s12957-022-02697-w,https://pubmed.ncbi.nlm.nih.gov/35836259/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,31389194,Sequence variants in genes causing nonsyndromic hearing loss in a Pakistani cohort.,2019,10.1002/mgg3.917,https://pubmed.ncbi.nlm.nih.gov/31389194/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PJVK,ENSG00000204311,Unsafe,17329413,A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function.,2007,10.1523/jneurosci.4975-06.2007,https://pubmed.ncbi.nlm.nih.gov/17329413/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,42630107,"Genetics in Heterotaxy: A Case Series and Literature Review on DNAH9, PKD1L1, MMP21, and GDF1.",2026,10.1111/cge.70227,https://pubmed.ncbi.nlm.nih.gov/42630107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,42644042,Biliary atresia-related liver fibrosis.,2026,10.3389/fcell.2026.1905495,https://pubmed.ncbi.nlm.nih.gov/42644042/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,41865132,"Autism spectrum disorder trios from consanguineous populations are enriched for rare homozygous variants, identifying 32 new candidate genes.",2026,10.1038/s41598-026-44288-9,https://pubmed.ncbi.nlm.nih.gov/41865132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,38247840,PKD1L1 Is Involved in Congenital Chylothorax.,2024,10.3390/cells13020149,https://pubmed.ncbi.nlm.nih.gov/38247840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,37675454,Loss of zebrafish pkd1l1 causes biliary defects that have implications for biliary atresia splenic malformation.,2023,10.1242/dmm.049326,https://pubmed.ncbi.nlm.nih.gov/37675454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,38460793,Pkd1l1-deficiency drives biliary atresia through ciliary dysfunction in biliary epithelial cells.,2024,10.1016/j.jhep.2024.02.031,https://pubmed.ncbi.nlm.nih.gov/38460793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,39753129,CIROZ is dispensable in ancestral vertebrates but essential for left-right patterning in humans.,2025,10.1016/j.ajhg.2024.12.006,https://pubmed.ncbi.nlm.nih.gov/39753129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,41579197,Genetic Burden in Congenital Anomalies of the Mitral and Tricuspid Valves: A Case-Control Study.,2026,10.1007/s00246-026-04163-w,https://pubmed.ncbi.nlm.nih.gov/41579197/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,36645229,Liver-restricted deletion of the biliary atresia candidate gene Pkd1l1 causes bile duct dysmorphogenesis and ciliopathy.,2023,10.1097/hep.0000000000000029,https://pubmed.ncbi.nlm.nih.gov/36645229/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,41247545,Genetic Burden in Congenital Anomalies of the Mitral and Tricuspid Valves: A Case-Control Study.,2026,10.1007/s00246-025-04081-3,https://pubmed.ncbi.nlm.nih.gov/41247545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,41283084,Decoding the Genetic Landscape of Postoperative Nausea and Vomiting in Cancer Surgery: A New Frontier in Personalized Medicine Driven by Genome-Wide Association Studies.,2025,10.1007/s13193-024-02172-w,https://pubmed.ncbi.nlm.nih.gov/41283084/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,37413993,Nodal flow transfers polycystin to determine mouse left-right asymmetry.,2023,10.1016/j.devcel.2023.06.002,https://pubmed.ncbi.nlm.nih.gov/37413993/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,41405813,Another ciliopathy? Uncovering the ciliary basis of biliary atresia.,2026,10.1007/s12072-025-10995-0,https://pubmed.ncbi.nlm.nih.gov/41405813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,40715143,Genetic findings of children with congenital heart diseases using chromosomal microarray and trio-based whole exome sequencing.,2025,10.1038/s41598-025-06977-9,https://pubmed.ncbi.nlm.nih.gov/40715143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,35474353,Exome sequencing in individuals with cardiovascular laterality defects identifies potential candidate genes.,2022,10.1038/s41431-022-01100-2,https://pubmed.ncbi.nlm.nih.gov/35474353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,36639367,Multiple pkd and piezo gene family members are required for atrioventricular valve formation.,2023,10.1038/s41467-023-35843-3,https://pubmed.ncbi.nlm.nih.gov/36639367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,39617559,"Gene expression profiles of Chinese medaka (Oryzias sinensis) primary hepatocytes in response to estrone (E1), 17β-estradiol (E2) and estriol (E3).",2025,10.1016/j.jes.2024.03.047,https://pubmed.ncbi.nlm.nih.gov/39617559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,38651949,BiliQML: a supervised machine-learning model to quantify biliary forms from digitized whole slide liver histopathological images.,2024,10.1152/ajpgi.00058.2024,https://pubmed.ncbi.nlm.nih.gov/38651949/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,33655537,Hydrops fetalis in PKD1L1-related heterotaxy: Report of two foetuses and expanding the phenotypic and molecular spectrum.,2021,10.1111/ahg.12417,https://pubmed.ncbi.nlm.nih.gov/33655537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,30664273,Identification of Polycystic Kidney Disease 1 Like 1 Gene Variants in Children With Biliary Atresia Splenic Malformation Syndrome.,2019,10.1002/hep.30515,https://pubmed.ncbi.nlm.nih.gov/30664273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,36942736,Exome-wide assessment of isolated biliary atresia: A report from the National Birth Defects Prevention Study using child-parent trios and a case-control design to identify novel rare variants.,2023,10.1002/ajmg.a.63185,https://pubmed.ncbi.nlm.nih.gov/36942736/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,36253874,Integrative analyses of genes related to liver ischemia reperfusion injury.,2022,10.1186/s41065-022-00255-8,https://pubmed.ncbi.nlm.nih.gov/36253874/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,32111882,The genetics of situs inversus without primary ciliary dyskinesia.,2020,10.1038/s41598-020-60589-z,https://pubmed.ncbi.nlm.nih.gov/32111882/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD1L1,ENSG00000158683,Unsafe,11863367,"The sequence, expression, and chromosomal localization of a novel polycystic kidney disease 1-like gene, PKD1L1, in human.",2002,10.1006/geno.2002.6719,https://pubmed.ncbi.nlm.nih.gov/11863367/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD2L2,ENSG00000078795,Unsafe,40022259,Genetic insights into cardiac conduction disorders from genome-wide association studies.,2025,10.1186/s40246-025-00732-x,https://pubmed.ncbi.nlm.nih.gov/40022259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD2L2,ENSG00000078795,Unsafe,37216541,Primary cilia TRP channel regulates hippocampal excitability.,2023,10.1073/pnas.2219686120,https://pubmed.ncbi.nlm.nih.gov/37216541/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD2L2,ENSG00000078795,Unsafe,36422197,Identification and Characterization of Novel Mutations in Chronic Kidney Disease (CKD) and Autosomal Dominant Polycystic Kidney Disease (ADPKD) in Saudi Subjects by Whole-Exome Sequencing.,2022,10.3390/medicina58111657,https://pubmed.ncbi.nlm.nih.gov/36422197/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD2L2,ENSG00000078795,Unsafe,31758253,Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries).,2019,10.1007/s00335-019-09820-5,https://pubmed.ncbi.nlm.nih.gov/31758253/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD2L2,ENSG00000078795,Unsafe,18670078,Expression of Pkd2l2 in testis is implicated in spermatogenesis.,2008,10.1248/bpb.31.1496,https://pubmed.ncbi.nlm.nih.gov/18670078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD2L2,ENSG00000078795,Unsafe,27866807,Genome-wide analysis of the nucleus accumbens identifies DNA methylation signals differentiating low/binge from heavy alcohol drinking.,2017,10.1016/j.alcohol.2016.11.003,https://pubmed.ncbi.nlm.nih.gov/27866807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD2L2,ENSG00000078795,Unsafe,27196058,Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice.,2016,10.1371/journal.pone.0155577,https://pubmed.ncbi.nlm.nih.gov/27196058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD2L2,ENSG00000078795,Unsafe,20043191,Overexpression of Trpp5 contributes to cell proliferation and apoptosis probably through involving calcium homeostasis.,2010,10.1007/s11010-009-0379-8,https://pubmed.ncbi.nlm.nih.gov/20043191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD2L2,ENSG00000078795,Unsafe,28271061,Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes.,2017,10.3389/fcell.2017.00005,https://pubmed.ncbi.nlm.nih.gov/28271061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD2L2,ENSG00000078795,Unsafe,10756092,"Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization.",2000,10.1006/geno.2000.6131,https://pubmed.ncbi.nlm.nih.gov/10756092/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD2L2,ENSG00000078795,Unsafe,24756726,The TRPP subfamily and polycystin-1 proteins.,2014,10.1007/978-3-642-54215-2_27,https://pubmed.ncbi.nlm.nih.gov/24756726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD2L2,ENSG00000078795,Unsafe,24336289,Direct recording and molecular identification of the calcium channel of primary cilia.,2013,10.1038/nature12832,https://pubmed.ncbi.nlm.nih.gov/24336289/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD2L2,ENSG00000078795,Unsafe,10602361,Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2).,1999,10.1038/sj.ejhg.5200383,https://pubmed.ncbi.nlm.nih.gov/10602361/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD2L2,ENSG00000078795,Unsafe,20095091,Expression of transient receptor potential channel mucolipin (TRPML)  and polycystine (TRPP) in the mouse inner ear.,2010,10.3109/00016480903013593,https://pubmed.ncbi.nlm.nih.gov/20095091/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKD2L2,ENSG00000078795,Unsafe,12667948,A polycystin-2-like large conductance cation channel in rat left ventricular myocytes.,2003,10.1016/s0008-6363(02)00858-1,https://pubmed.ncbi.nlm.nih.gov/12667948/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,42237635,PKMYT1 is a targetable vulnerability in del(17p) high-risk multiple myeloma.,2026,10.1182/blood.2026033819,https://pubmed.ncbi.nlm.nih.gov/42237635/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,42387642,PKMYT1 in Cancer: Beyond Cell Cycle Checkpoints to Context-Dependent Therapeutic Vulnerability.,2026,10.1002/gcc.70151,https://pubmed.ncbi.nlm.nih.gov/42387642/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,42249771,Integrative Transcriptomic and Functional Analysis of PKMYT1 Reveals a Potential Therapeutic Target in Chronic Lymphocytic Leukemia.,2026,10.1002/hon.70208,https://pubmed.ncbi.nlm.nih.gov/42249771/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,42849655,Genome-wide CRISPR screen identifies PKMYT1 inhibition as a synthetic lethal vulnerability in IDH1-mutant glioma.,2026,10.1016/j.canlet.2026.218887,https://pubmed.ncbi.nlm.nih.gov/42849655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,42496268,"Wee Kinases, Big Impact: Wee and Myt Kinases as Critical Regulators of Meiotic Progression.",2026,10.3390/jdb14030029,https://pubmed.ncbi.nlm.nih.gov/42496268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,41390597,E2F1-mediated PKMYT1 upregulation promotes prostate cancer progression by inhibiting the PPAR signaling pathway.,2025,10.1038/s41598-025-32218-0,https://pubmed.ncbi.nlm.nih.gov/41390597/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,41592600,FOXM1 influences DNA methylation to augment TACC3 alternative splicing directed by KAT2A in hepatocellular carcinoma.,2026,10.3350/cmh.2025.1370,https://pubmed.ncbi.nlm.nih.gov/41592600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,41815149,Comprehensive analysis identifies PKMYT1 as an oncogene and potential prognostic and immunological biomarker in lung adenocarcinoma.,2026,10.21037/tcr-2025-1640,https://pubmed.ncbi.nlm.nih.gov/41815149/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,42133791,Bevacizumab induces apoptosis in glioblastoma cells by upregulating miR-4695-5p to inhibit PKMYT1.,2026,10.1080/15476286.2026.2670829,https://pubmed.ncbi.nlm.nih.gov/42133791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,42243523,PKMYT1 has an important role in the timing and fidelity of chromosome segregation.,2026,10.1038/s44319-026-00809-1,https://pubmed.ncbi.nlm.nih.gov/42243523/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,42652256,"Design, Synthesis, Biological Activity Evaluation, and Molecular Docking of 2-Aminopyrimidine-Based PKMYT1 Inhibitors.",2026,10.3390/biomedicines14081876,https://pubmed.ncbi.nlm.nih.gov/42652256/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,42247169,Diabetes-associated MYT1 and ST18 genes regulate human beta cell insulin secretion and survival via other diabetes risk genes.,2026,10.1007/s00125-026-06757-8,https://pubmed.ncbi.nlm.nih.gov/42247169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,41006713,Exploring PKMYT1 as a potential marker for colorectal cancer progression through bioinformatics analyses and experimental validation.,2025,10.1038/s41598-025-18430-y,https://pubmed.ncbi.nlm.nih.gov/41006713/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,41271882,A Comprehensive multi-network analysis of ceRNAs and transcription factors for papillary thyroid carcinoma diagnosis and prognosis.,2025,10.1038/s41598-025-25114-0,https://pubmed.ncbi.nlm.nih.gov/41271882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,41973002,"ATR and PKMYT1 Inhibition Resensitizes a Subset of TNBC Patient-Derived Models to Carboplatin, Inducing Mitotic Catastrophe.",2026,10.1158/2767-9764.crc-25-0044,https://pubmed.ncbi.nlm.nih.gov/41973002/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,41617394,Targeting PKMYT1 enhances antitumor immune responses to PD-L1 blockade in castration-resistant prostate cancer.,2026,10.1136/jitc-2025-013247,https://pubmed.ncbi.nlm.nih.gov/41617394/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,41693360,PKMYT1/FOXM1/Snail Axis Promotes Metastasis in Clear Cell Renal Cell Carcinoma by Inducing Epithelial-mesenchymal Transition.,2026,10.1002/cbin.70139,https://pubmed.ncbi.nlm.nih.gov/41693360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,41315240,Discovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation.,2025,10.1038/s41467-025-65796-8,https://pubmed.ncbi.nlm.nih.gov/41315240/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,42788344,Tumor‑immune spatiotemporal co‑evolution: A new paradigm for understanding and overcoming therapy resistance in metastatic castration‑resistant prostate cancer (Review).,2026,10.3892/ijmm.2026.5997,https://pubmed.ncbi.nlm.nih.gov/42788344/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,42773250,E2F3 amplification primes bladder cancer cells for premature mitosis.,2026,10.1038/s41417-026-01084-x,https://pubmed.ncbi.nlm.nih.gov/42773250/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,42911706,Discovery of 4-Aminoquinazoline Derivatives as Potent PKMYT1 Inhibitors via Hydrogen Bond Donor-To-Acceptor Conversion for CCNE1-Amplified Cancers.,2026,10.1021/acs.jmedchem.6c01446,https://pubmed.ncbi.nlm.nih.gov/42911706/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,42186170,A Possibility of Synthetic Lethality: Wee1 Kinase as a Promising Treating Target for Cancer.,2026,10.1002/med.70057,https://pubmed.ncbi.nlm.nih.gov/42186170/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,42526071,"Design, synthesis, and biological evaluation of pyrrolo[2,3-c]pyridin-7-one derivatives as PKMYT1 inhibitors targeting CCNE1-amplified cancers.",2026,10.1016/j.ejmech.2026.119161,https://pubmed.ncbi.nlm.nih.gov/42526071/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,42165607,Recent advances in the discovery of PKMYT1-targeting drugs: a patent review (2021-2025).,2026,10.1080/13543776.2026.2674071,https://pubmed.ncbi.nlm.nih.gov/42165607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,42003565,Discovery of Naphthyridinone Derivatives as Selective PKMYT1/WEE1 Dual Inhibitors for Cancer Therapy.,2026,10.1021/acs.jmedchem.5c03521,https://pubmed.ncbi.nlm.nih.gov/42003565/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,41125481,WEE-family kinases in cancer: synthetic lethal interactions and drug discovery.,2026,10.1016/j.tips.2025.09.005,https://pubmed.ncbi.nlm.nih.gov/41125481/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,41086259,Drugging the DNA damage response in the clinic: going beyond PARP.,2026,10.1080/14737140.2025.2575825,https://pubmed.ncbi.nlm.nih.gov/41086259/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PKMYT1,ENSG00000127564,Unsafe,42874919,Emerging Therapeutic targets and Early-phase drug Development in Gynecological Malignancies.,2026,10.1016/j.annonc.2026.10.101,https://pubmed.ncbi.nlm.nih.gov/42874919/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,41328535,Phospholipase A and acyltransferases as novel regulator of organelle dynamics.,2026,10.1093/jb/mvaf076,https://pubmed.ncbi.nlm.nih.gov/41328535/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,40345663,Plaat1 deficiency reduces cardiac cardiolipin content and impairs exercise tolerance.,2025,10.1016/j.jlr.2025.100822,https://pubmed.ncbi.nlm.nih.gov/40345663/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,42222932,"Correction to ""Effects of Lipid Metabolism-Related Genes PTGIS and HRASLS on Phenotype, Prognosis, and Tumor Immunity in Lung Squamous Cell Carcinoma"".",2026,10.1155/omcl/9853912,https://pubmed.ncbi.nlm.nih.gov/42222932/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,40988925,A lipid metabolism and lysosome-based risk signature for prognosis and immune response prediction in uterine corpus endometrial carcinoma.,2025,10.3389/fgene.2025.1594682,https://pubmed.ncbi.nlm.nih.gov/40988925/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,40074088,The PLAAT family as phospholipid-related enzymes.,2025,10.1016/j.plipres.2025.101331,https://pubmed.ncbi.nlm.nih.gov/40074088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,36703911,"Effects of Lipid Metabolism-Related Genes PTGIS and HRASLS on Phenotype, Prognosis, and Tumor Immunity in Lung Squamous Cell Carcinoma.",2023,10.1155/2023/6811625,https://pubmed.ncbi.nlm.nih.gov/36703911/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,37818970,PLAAT1 expression triggers fragmentation of mitochondria in an enzyme activity-dependent manner.,2023,10.1093/jb/mvad079,https://pubmed.ncbi.nlm.nih.gov/37818970/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,38864338,Gene loss and relaxed selection of &lt;i&gt;plaat1&lt;/i&gt; in vertebrates adapted to low-light environments.,2024,10.1098/rspb.2023.2847,https://pubmed.ncbi.nlm.nih.gov/38864338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,35743156,PLAAT1 Exhibits Phosphatidylcholine:Monolysocardiolipin Transacylase Activity.,2022,10.3390/ijms23126714,https://pubmed.ncbi.nlm.nih.gov/35743156/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,36172355,PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish.,2022,10.3389/fimmu.2022.979919,https://pubmed.ncbi.nlm.nih.gov/36172355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,37639552,Copy number variation as a tool for implementing pregnancy as an aging model.,2023,10.18632/aging.204936,https://pubmed.ncbi.nlm.nih.gov/37639552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,35526800,PLAAT1 promotes p53 degradation via autophagy-lysosome pathway in zebrafish.,2022,10.1016/j.fsi.2022.05.001,https://pubmed.ncbi.nlm.nih.gov/35526800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,38297314,Malignant peritoneal mesotheliomas of rats induced by multiwalled carbon nanotubes and amosite asbestos: transcriptome and epigenetic profiles.,2024,10.1186/s12989-024-00565-x,https://pubmed.ncbi.nlm.nih.gov/38297314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,40744127,Population structure and signature of selection for body size in some Iranian and exotic horse breeds.,2025,10.1016/j.jevs.2025.105658,https://pubmed.ncbi.nlm.nih.gov/40744127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,38517673,Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma.,2024,10.1007/s11596-023-2806-6,https://pubmed.ncbi.nlm.nih.gov/38517673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,36455238,Construction of a prognostic model for lung squamous cell carcinoma based on immune-related genes.,2023,10.1093/carcin/bgac098,https://pubmed.ncbi.nlm.nih.gov/36455238/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,30620559,Activity-Based Protein Profiling Identifies α-Ketoamides as Inhibitors for Phospholipase A2 Group XVI.,2019,10.1021/acschembio.8b00969,https://pubmed.ncbi.nlm.nih.gov/30620559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,26503625,The HRASLS (PLA/AT) subfamily of enzymes.,2015,10.1186/s12929-015-0210-7,https://pubmed.ncbi.nlm.nih.gov/26503625/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,35127715,Identification and Validation of a Prognostic Risk-Scoring Model Based on Ferroptosis-Associated Cluster in Acute Myeloid Leukemia.,2021,10.3389/fcell.2021.800267,https://pubmed.ncbi.nlm.nih.gov/35127715/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,35626050,Distinct Gene Expression Profiles of Matched Primary and Metastatic Triple-Negative Breast Cancers.,2022,10.3390/cancers14102447,https://pubmed.ncbi.nlm.nih.gov/35626050/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,31205500,FAM84B promotes prostate tumorigenesis through a network alteration.,2019,10.1177/1758835919846372,https://pubmed.ncbi.nlm.nih.gov/31205500/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,27623847,Comparative analyses of isoforms of the calcium-independent phosphatidylethanolamine N-acyltransferase PLAAT-1 in humans and mice.,2016,10.1194/jlr.m071290,https://pubmed.ncbi.nlm.nih.gov/27623847/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAAT1,ENSG00000127252,Unsafe,21880860,Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes.,2011,10.1194/jlr.m015081,https://pubmed.ncbi.nlm.nih.gov/21880860/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC8L1,ENSG00000173261,Unsafe,35710353,miRNA-mRNA analysis of sheep adrenal glands reveals the network regulating reproduction.,2022,10.1186/s12863-022-01060-y,https://pubmed.ncbi.nlm.nih.gov/35710353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLAC8L1,ENSG00000173261,Unsafe,25702041,RNA sequencing to study gene expression and SNP variations associated with growth in zebrafish fed a plant protein-based diet.,2015,10.1007/s10126-015-9624-1,https://pubmed.ncbi.nlm.nih.gov/25702041/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,42625859,"Dysregulation of piRNA biogenesis-associated proteins in cancer: mechanisms, evidence, and translational constraints.",2026,10.3389/fmolb.2026.1906635,https://pubmed.ncbi.nlm.nih.gov/42625859/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,40259095,Phospholipase D6 activates Wnt/β-catenin signaling through mitochondrial metabolic reprogramming to promote tumorigenesis in colorectal cancer.,2025,10.1038/s12276-025-01446-9,https://pubmed.ncbi.nlm.nih.gov/40259095/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,37569546,Expression of Phospholipase D Family Member 6 in Bovine Testes and Its Molecular Characteristics.,2023,10.3390/ijms241512172,https://pubmed.ncbi.nlm.nih.gov/37569546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,40263465,TOM20-driven E3 ligase recruitment regulates mitochondrial dynamics through PLD6.,2026,10.1038/s41589-025-01894-4,https://pubmed.ncbi.nlm.nih.gov/40263465/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,41640016,PRKN activation for mitophagy requires an NME3-regulated phosphatidic acid signal that separates mitochondria from endoplasmic reticulum tethering.,2026,10.1080/15548627.2026.2623981,https://pubmed.ncbi.nlm.nih.gov/41640016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,36257818,A Germline-Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells.,2022,10.1002/advs.202203631,https://pubmed.ncbi.nlm.nih.gov/36257818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,40355014,Sirt6 deficiency exacerbates angiotensin II-induced lipid nephrotoxicity by affecting PLD6-derived cardiolipin metabolism in podocytes.,2025,10.1016/j.cellsig.2025.111858,https://pubmed.ncbi.nlm.nih.gov/40355014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,39526719,"Association of overexpression of PLD6, CHRAC1 and PDCD5 with type 2 diabetes mellitus.",2024,10.17392/1739-21-02,https://pubmed.ncbi.nlm.nih.gov/39526719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,41273173,DNA methylation dictates histone modifications in developing male germ cells in the mouse.,2025,10.1093/nar/gkaf1240,https://pubmed.ncbi.nlm.nih.gov/41273173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,33783608,Cellular and subcellular localization of endogenous phospholipase D6 in seminiferous tubules of mouse testes.,2021,10.1007/s00441-021-03442-7,https://pubmed.ncbi.nlm.nih.gov/33783608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,38843396,TRABD modulates mitochondrial homeostasis and tissue integrity.,2024,10.1016/j.celrep.2024.114304,https://pubmed.ncbi.nlm.nih.gov/38843396/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,37584589,NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering.,2023,10.1083/jcb.202301091,https://pubmed.ncbi.nlm.nih.gov/37584589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,37782162,Age-related genes affecting the immune cell infiltration in ulcerative colitis revealed by weighted correlation network analysis and machine learning.,2023,10.26355/eurrev_202309_33768,https://pubmed.ncbi.nlm.nih.gov/37782162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,33635934,"yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis.",2021,10.1371/journal.pgen.1009265,https://pubmed.ncbi.nlm.nih.gov/33635934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,38996145,Construction of prognostic markers for pancreatic adenocarcinoma based on mitochondrial fusion-related genes.,2024,10.1097/md.0000000000038843,https://pubmed.ncbi.nlm.nih.gov/38996145/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,29113556,Phospholipase D Family Member 6 Is a Surface Marker for Enrichment of Undifferentiated Spermatogonia in Prepubertal Boars.,2018,10.1089/scd.2017.0140,https://pubmed.ncbi.nlm.nih.gov/29113556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,35273654,PIWI-Interacting RNA Pathway Genes: Potential Biomarkers for Clear Cell Renal Cell Carcinoma.,2022,10.1155/2022/3480377,https://pubmed.ncbi.nlm.nih.gov/35273654/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,34407824,Genes underlying the evolution of tetrapod testes size.,2021,10.1186/s12915-021-01107-z,https://pubmed.ncbi.nlm.nih.gov/34407824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,36127679,First characterization of PIWI-interacting RNA clusters in a cichlid fish with a B chromosome.,2022,10.1186/s12915-022-01403-2,https://pubmed.ncbi.nlm.nih.gov/36127679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,28852571,Glycerol kinase-like proteins cooperate with Pld6 in regulating sperm mitochondrial sheath formation and male fertility.,2017,10.1038/celldisc.2017.30,https://pubmed.ncbi.nlm.nih.gov/28852571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,29691636,Genome-wide association for testis weight in the diversity outbred mouse population.,2018,10.1007/s00335-018-9745-8,https://pubmed.ncbi.nlm.nih.gov/29691636/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,21124956,Altered DNA methylation in leukocytes with trisomy 21.,2010,10.1371/journal.pgen.1001212,https://pubmed.ncbi.nlm.nih.gov/21124956/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,21397847,MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline.,2011,10.1016/j.devcel.2011.01.005,https://pubmed.ncbi.nlm.nih.gov/21397847/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLD6,ENSG00000179598,Unsafe,17028579,A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis.,2006,10.1038/ncb1487,https://pubmed.ncbi.nlm.nih.gov/17028579/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,42366369,DAPR-AM-Net: an end-to-end smart farming system powered by dual-attention progressive refinement and adaptive MixUp for explainable tomato leaf disease classification and forecasting.,2026,10.1186/s13007-026-01556-z,https://pubmed.ncbi.nlm.nih.gov/42366369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,42803837,Retinal neovascularization detection from fundus images using deformable attention ResNet and swarm-hiking optimization.,2026,10.1007/s10792-026-04143-2,https://pubmed.ncbi.nlm.nih.gov/42803837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,41293648,Predictors of Abdominal Pain Duration in Henoch-Schönlein Purpura and Nomogram Model Development: A Retrospective Study of 220 Cases.,2025,10.2147/jir.s549824,https://pubmed.ncbi.nlm.nih.gov/41293648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,41765073,Effects of low-level lead exposure on hematological parameters and the possible underlying mechanisms.,2026,10.1016/j.envpol.2026.127884,https://pubmed.ncbi.nlm.nih.gov/41765073/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,38596466,Proteomic analysis of the serum in dogs with pulmonary hypertension secondary to myxomatous mitral valve disease: the preliminary study.,2024,10.3389/fvets.2024.1327453,https://pubmed.ncbi.nlm.nih.gov/38596466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,34784955,Curcumin inhibits ovarian cancer progression by regulating circ-PLEKHM3/miR-320a/SMG1 axis.,2021,10.1186/s13048-021-00916-8,https://pubmed.ncbi.nlm.nih.gov/34784955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,35877430,Using AI-Based Evolutionary Algorithms to Elucidate Adult Brain Tumor (Glioma) Etiology Associated with IDH1 for Therapeutic Target Identification.,2022,10.3390/cimb44070206,https://pubmed.ncbi.nlm.nih.gov/35877430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,33836522,"Dose-area product ratio in external small-beam radiotherapy: beam shape, size and energy dependencies in clinical photon beams.",2021,10.1088/2057-1976/abf6aa,https://pubmed.ncbi.nlm.nih.gov/33836522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,33597502,The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction.,2021,10.1038/s41392-020-00445-8,https://pubmed.ncbi.nlm.nih.gov/33597502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,33447051,Biostable Double-Strand Circular Aptamers Conjugated Onto Dendrimers for Specific Capture and Inhibition of Circulating Leukemia Cells.,2020,10.2147/ott.s287720,https://pubmed.ncbi.nlm.nih.gov/33447051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,34487423,Characterization of the diastaphenazine/izumiphenazine C biosynthetic gene cluster from plant endophyte Streptomyces diastaticus W2.,2022,10.1111/1751-7915.13909,https://pubmed.ncbi.nlm.nih.gov/34487423/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,28327474,Measurement and properties of the dose-area product ratio in external small-beam radiotherapy.,2017,10.1088/1361-6560/aa6861,https://pubmed.ncbi.nlm.nih.gov/28327474/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,29848962,Postprandial Glycaemic Responses of Dried Fruit-Containing Meals in Healthy Adults: Results from a Randomised Trial.,2018,10.3390/nu10060694,https://pubmed.ncbi.nlm.nih.gov/29848962/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,34202351,Whole-Exome Sequencing to Identify Potential Genetic Risk in Substance Use Disorders: A Pilot Feasibility Study.,2021,10.3390/jcm10132810,https://pubmed.ncbi.nlm.nih.gov/34202351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,32526247,mRNA and microRNA selection for breast cancer molecular subtype stratification using meta-heuristic based algorithms.,2020,10.1016/j.ygeno.2020.06.014,https://pubmed.ncbi.nlm.nih.gov/32526247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,24957825,Defining daptomycin resistance prevention exposures in vancomycin-resistant Enterococcus faecium and E. faecalis.,2014,10.1128/aac.00098-14,https://pubmed.ncbi.nlm.nih.gov/24957825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,20547804,"Daptomycin-oxacillin combinations in treatment of experimental endocarditis caused by daptomycin-nonsusceptible strains of methicillin-resistant Staphylococcus aureus with evolving oxacillin susceptibility (the ""seesaw effect"").",2010,10.1128/aac.00487-10,https://pubmed.ncbi.nlm.nih.gov/20547804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,21625609,An exploration of the control of micturition using a novel in situ arterially perfused rat preparation.,2011,10.3389/fnins.2011.00062,https://pubmed.ncbi.nlm.nih.gov/21625609/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,20498310,Cell wall thickening is not a universal accompaniment of the daptomycin nonsusceptibility phenotype in Staphylococcus aureus: evidence for multiple resistance mechanisms.,2010,10.1128/aac.00122-10,https://pubmed.ncbi.nlm.nih.gov/20498310/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,19028694,"Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling.",2009,10.1074/jbc.m807000200,https://pubmed.ncbi.nlm.nih.gov/19028694/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,37611733,Dynamics of Pediatric Antibiotic Use Differ between High- and Low-Prescribing Clinics after Pneumococcal Conjugate Vaccines.,2023,10.1016/j.jpeds.2023.113679,https://pubmed.ncbi.nlm.nih.gov/37611733/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,21478385,High on-treatment platelet reactivity to both aspirin and clopidogrel is associated with the highest risk of adverse events following percutaneous coronary intervention.,2011,10.1136/hrt.2010.220491,https://pubmed.ncbi.nlm.nih.gov/21478385/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLEKHM3,ENSG00000178385,Unsafe,25250117,Attitude toward death in healthy people and patients with diabetes and cancer.,2013,,https://pubmed.ncbi.nlm.nih.gov/25250117/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42610666,Age-Opposed Rewiring of Upstream Translation-Initiation Pattern Across Different Types of Human Cancers.,2026,10.1177/15578100261479259,https://pubmed.ncbi.nlm.nih.gov/42610666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42719140,PLK1/FOXM1-associated tumor-cell state and macrophage-related immune features in endometrial cancer.,2026,10.3389/fonc.2026.1931435,https://pubmed.ncbi.nlm.nih.gov/42719140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42310501,C1orf226 Promotes Glioma Stemness and Oncogenesis in Glioma via PLK1-Mediated Wnt/β-Catenin Signaling.,2026,10.1002/cam4.72048,https://pubmed.ncbi.nlm.nih.gov/42310501/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42758015,Onvansertib-mediated PLK1 inhibition impairs spermatogenesis in the murine testis.,2026,10.4103/aja202635,https://pubmed.ncbi.nlm.nih.gov/42758015/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42893509,Tubocapsenolide A Overcomes Oxaliplatin Resistance in Colorectal Cancer by Targeting PLK1 to Impair CEP55-ESCRT-Associated Vesicular Damage Clearance.,2026,10.1002/advs.78310,https://pubmed.ncbi.nlm.nih.gov/42893509/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42556723,Determinants of protein phosphatase 1β substrate specificity for MyPhoNE motif-containing proteins.,2026,10.1016/j.jbc.2026.113392,https://pubmed.ncbi.nlm.nih.gov/42556723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42454595,"Bosutinib Inhibits USP9X to Suppress the Proliferation, Migration, Angiogenesis and Glycolysis of Hepatocellular Carcinoma Cells by Deubiquitinating PLK1.",2026,10.1111/1440-1681.70147,https://pubmed.ncbi.nlm.nih.gov/42454595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42378032,A tailored in vivo CRISPR screen identifies BAP1 as a potent tumor suppressor of sarcoma.,2026,10.1172/jci.insight.192686,https://pubmed.ncbi.nlm.nih.gov/42378032/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42659832,Targeting SUV4-20H2-mediated H4K20 methylation restrains growth and migration in pediatric high-grade astrocytomas.,2026,10.1016/j.neurot.2026.e01053,https://pubmed.ncbi.nlm.nih.gov/42659832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42205755,Nitidine chloride suppresses polo-like kinase 1 via MYCN-associated transcriptional regulation in colorectal cancer: a multi-omics and spatial transcriptomics study.,2026,10.3389/fonc.2026.1824796,https://pubmed.ncbi.nlm.nih.gov/42205755/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,41793675,Dysregulated TMPO-AS1/let-7b-5p/PLK1/E2F1 Axis Associated with Poor Prognosis in Lung Adenocarcinoma.,2026,10.31557/apjcp.2026.27.3.967,https://pubmed.ncbi.nlm.nih.gov/41793675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42494595,Plasticizers and prostate cancer: unraveling the link through network toxicology and machine learning.,2026,10.3389/fonc.2026.1768691,https://pubmed.ncbi.nlm.nih.gov/42494595/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42494171,GRP78/BiP as a novel midbody component induces mitotic exit failure via PLK1 stabilization in hepatocellular carcinoma.,2026,,https://pubmed.ncbi.nlm.nih.gov/42494171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,41227386,Polo-like Kinase 1 Activation Regulates Angiotensin II-Induced Contraction in Pudendal and Small Mesenteric Arteries from Mice.,2025,10.3390/cells14211741,https://pubmed.ncbi.nlm.nih.gov/41227386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42257837,Targeting VAMP5 suppresses PLK1-driven growth of gliomas with high NDRG4 expression.,2026,10.1007/s11060-026-05666-5,https://pubmed.ncbi.nlm.nih.gov/42257837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42623604,Selective Macrocyclic WEE1 Kinase Inhibitors with Strong Efficacy against Patient-Derived Colorectal Cancer Organoids.,2026,10.1021/acs.jmedchem.6c00018,https://pubmed.ncbi.nlm.nih.gov/42623604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,41252565,Targeting PLK1 Reduces MMP10 to Enhance Radiosensitivity in HPV- Head and Neck Cancer.,2026,10.1158/1078-0432.ccr-25-2179,https://pubmed.ncbi.nlm.nih.gov/41252565/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,41608586,PLK1 stabilizes β-catenin to drive colorectal carcinogenesis through NFKB2-mediated transcriptional activation of USP2a and site-specific phosphorylation.,2026,10.7150/thno.122368,https://pubmed.ncbi.nlm.nih.gov/41608586/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,41481275,PLK1 inhibition by volasertib suppresses key transcriptional regulators underlying fibroblast activation and pulmonary fibrosis.,2026,10.1152/ajplung.00204.2025,https://pubmed.ncbi.nlm.nih.gov/41481275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42321780,Biomimetic fusion nanosystem from ginger exosomes and tumor cell membranes: boosting PLK1-targeted therapy in BRCA-heterogeneous HGSOC.,2026,10.1186/s12951-026-04656-z,https://pubmed.ncbi.nlm.nih.gov/42321780/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42311823,Immunoinformatic-guided design of a polo-like kinase 1 (PLK1)-targeted multi-epitope vaccine with preliminary &lt;i&gt;in vitro&lt;/i&gt; validation.,2026,10.3389/fbinf.2026.1843200,https://pubmed.ncbi.nlm.nih.gov/42311823/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,41870184,"The Trifecta of Polo-Like Kinases, Cancer, and the Immune System: Emerging Intersections and Therapeutic Insights.",2026,10.1158/1541-7786.mcr-25-1138,https://pubmed.ncbi.nlm.nih.gov/41870184/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,40615690,Pan-RAS inhibitors and polo-like kinase 1: promising targets in colorectal cancer.,2025,10.1038/s41388-025-03484-z,https://pubmed.ncbi.nlm.nih.gov/40615690/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,40612941,PLK1 in cancer therapy: a comprehensive review of immunomodulatory mechanisms and therapeutic opportunities.,2025,10.3389/fimmu.2025.1602752,https://pubmed.ncbi.nlm.nih.gov/40612941/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42887067,"Design, synthesis, and biological evaluation of 2-aminopyrimidine-5-carboxamide derivatives as potent selective Wee1 inhibitors.",2026,10.1016/j.ejmech.2026.119402,https://pubmed.ncbi.nlm.nih.gov/42887067/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42076055,"Mitotic Machinery Dysregulation in Lung Cancer: Biological Roles, Therapeutic Targeting, and Combination Strategies.",2026,10.3390/pharmaceutics18040402,https://pubmed.ncbi.nlm.nih.gov/42076055/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42878202,A Nanodelivery Platform Harnessing Synthetic Lethality and Efferocytosis Inhibition for Synergistically Enhanced Immunotherapy of Triple-Negative Breast Cancer.,2026,10.1002/smll.76306,https://pubmed.ncbi.nlm.nih.gov/42878202/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,41458961,Clinical relevance of PLK1 in epithelial ovarian cancer.,2025,10.3389/fphar.2025.1702273,https://pubmed.ncbi.nlm.nih.gov/41458961/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,41516322,Overcoming Therapeutic Resistance in Triple-Negative Breast Cancer: Targeting the Undrugged Kinome.,2025,10.3390/ijms27010450,https://pubmed.ncbi.nlm.nih.gov/41516322/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42008362,A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English.,2026,10.3791/67979,https://pubmed.ncbi.nlm.nih.gov/42008362/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42459306,"ERCC6L in human cancers: oncogenic functions, molecular mechanisms, and clinical implications as a prognostic biomarker and therapeutic target.",2026,10.3389/fonc.2026.1812829,https://pubmed.ncbi.nlm.nih.gov/42459306/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42865184,In silico Prediction of Protein Targets for Benzofuranone Ring-containing Agents and Molecular Docking Analysis.,2026,10.2174/0113894501520248261002101424,https://pubmed.ncbi.nlm.nih.gov/42865184/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42708287,"Design of Quinazoline Dual Inhibitors Targeting Focal Adhesion Kinase and Polo-like Kinase 1 for Metastatic Cancers: QSAR, Pharmacophore Modelling, and Molecular Docking Approaches.",2026,10.2174/0113816128475011260821100240,https://pubmed.ncbi.nlm.nih.gov/42708287/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK1,ENSG00000166851,Unsafe,42337879,Cyperotundone Regulates Polo-like Kinase 1-mediated Glycolysis to Inhibit the Proliferation of Breast Cancer Cells.,2026,10.2174/0113892010439840260417071159,https://pubmed.ncbi.nlm.nih.gov/42337879/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,42894194,CFI-400945 enhances radiosensitivity in colorectal cancer models by promoting mitotic dysregulation and DNA damage-associated apoptosis.,2026,10.1186/s12935-026-04407-y,https://pubmed.ncbi.nlm.nih.gov/42894194/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,42316241,Combined inhibition of PLK4 and PPM1D promotes cell death in cancer cells with 17q amplification.,2026,10.1186/s12935-026-04391-3,https://pubmed.ncbi.nlm.nih.gov/42316241/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,41932203,Migrasome-mediated clearance of excess PLK4 defines a targetable vulnerability.,2026,10.1016/j.ebiom.2026.106237,https://pubmed.ncbi.nlm.nih.gov/41932203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,41092110,Polo-like kinase 4 (PLK4) as a therapeutic target in breast cancer.,2025,10.1093/carcin/bgaf067,https://pubmed.ncbi.nlm.nih.gov/41092110/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,41488365,Polo-like kinase 4: A molecular linchpin in cancer and its management.,2025,10.1016/j.isci.2025.114186,https://pubmed.ncbi.nlm.nih.gov/41488365/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,41088205,High expression of polo-like kinase 4 predicts worse progression-free survival in diffuse large B cell lymphoma patients treated with R-CHOP.,2025,10.1186/s12957-025-04017-4,https://pubmed.ncbi.nlm.nih.gov/41088205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,42288516,The PLK4 inhibitor RP-1664 demonstrates potent efficacy in neuroblastoma preclinical models through a dual mechanism of sensitivity.,2026,10.1038/s41467-026-74061-5,https://pubmed.ncbi.nlm.nih.gov/42288516/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,42220890,Tipping the balance: synthesis and evaluation of centrinone-based degraders of polo-like kinase 4.,2026,10.1039/d5cb00315f,https://pubmed.ncbi.nlm.nih.gov/42220890/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,42652193,"Design, Synthesis, and Biological Activity Evaluation of Quinazoline-Based PLK4 Inhibitors.",2026,10.3390/biomedicines14081811,https://pubmed.ncbi.nlm.nih.gov/42652193/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,41932639,TFEB-mediated autophagy dysregulation links with PRPF31 deficiency-induced photoreceptor death via PLK4 downregulation.,2026,10.1016/j.exer.2026.111000,https://pubmed.ncbi.nlm.nih.gov/41932639/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,42762966,CD20 targeted nanomedicine enhances anti-tumor immunity in diffuse large B-cell lymphoma by activating cGAS/STING pathway.,2026,10.1016/j.canlet.2026.218850,https://pubmed.ncbi.nlm.nih.gov/42762966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,42185629,GSDME acts as an epigenetic modifier to promote melanoma development via centriole biogenesis regulator PLK4.,2026,10.1038/s41418-026-01767-w,https://pubmed.ncbi.nlm.nih.gov/42185629/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,40940791,Polo-like Kinase 4: A Molecular Culprit in Skin Cancer Pathogenesis.,2025,10.3390/cells14171381,https://pubmed.ncbi.nlm.nih.gov/40940791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,40860200,PLK4 as a Key Regulator of Neuroblastoma Differentiation and a Promising Therapeutic Target.,2025,10.7150/ijbs.111449,https://pubmed.ncbi.nlm.nih.gov/40860200/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,40296663,PLK4 Inhibition as a Strategy to Enhance Non-Small Cell Lung Cancer Radiosensitivity.,2025,10.1158/1535-7163.mct-24-0978,https://pubmed.ncbi.nlm.nih.gov/40296663/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,42099105,Cavitation-Free Acoustic Sensitization Enhances PLK4-Targeted Therapy Using the Phillyrin Derivative DE02 in Osteosarcoma.,2026,10.1177/10849785261446291,https://pubmed.ncbi.nlm.nih.gov/42099105/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,40021845,Drosophila Alms1 proteins regulate centriolar cartwheel assembly by enabling Plk4-Ana2 amplification loop.,2025,10.1038/s44318-025-00382-8,https://pubmed.ncbi.nlm.nih.gov/40021845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,42034049,Migrasome-mediated clearance of PLK4: a novel mechanism for centrosome homeostasis and tumor targeting.,2026,10.1016/j.ebiom.2026.106263,https://pubmed.ncbi.nlm.nih.gov/42034049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,42870781,Kinase-based molecular subtyping and a prognostic risk model in colorectal cancer with functional validation of PLK4.,2026,10.21037/tcr-2026-1446,https://pubmed.ncbi.nlm.nih.gov/42870781/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,41948931,Targeting KIFC1 to disrupt centrosome clustering and trigger anaphase catastrophe in small-cell lung cancer.,2026,10.1172/jci.insight.199352,https://pubmed.ncbi.nlm.nih.gov/41948931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,42463132,"Discovery of ZSL-M028: A Potent, Selective and Orally Available Quinazoline-Based PLK4 Inhibitor Targeting TRIM37-Amplified Neuroblastoma.",2026,10.1021/acs.jmedchem.6c01348,https://pubmed.ncbi.nlm.nih.gov/42463132/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,41086259,Drugging the DNA damage response in the clinic: going beyond PARP.,2026,10.1080/14737140.2025.2575825,https://pubmed.ncbi.nlm.nih.gov/41086259/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,40662493,"Discovery of novel dual-targeting inhibitors against PLK1-PBD and PLK4-PB3: structure-guided pharmacophore modelling, virtual screening, molecular docking, molecular dynamics simulation, and biological evaluation.",2025,10.1080/14756366.2025.2522810,https://pubmed.ncbi.nlm.nih.gov/40662493/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,40823488,"Design, synthesis, and biological evaluation of 5-chlorine-2-amino-pyrimidine derivatives as potent PLK4 inhibitors.",2025,10.1039/d5md00435g,https://pubmed.ncbi.nlm.nih.gov/40823488/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,40378279,"Discovery of RP-1664: A First-in-Class Orally Bioavailable, Selective PLK4 Inhibitor.",2025,10.1021/acs.jmedchem.5c00529,https://pubmed.ncbi.nlm.nih.gov/40378279/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,38264947,Seize the engine: Emerging cell cycle targets in breast cancer.,2024,10.1002/ctm2.1544,https://pubmed.ncbi.nlm.nih.gov/38264947/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,40257113,PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential.,2025,10.1002/cm.22031,https://pubmed.ncbi.nlm.nih.gov/40257113/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PLK4,ENSG00000142731,Unsafe,40255404,Clinical potential and experimental validation of prognostic genes in hepatocellular carcinoma revealed by risk modeling utilizing single cell and transcriptome constructs.,2025,10.3389/fimmu.2025.1541252,https://pubmed.ncbi.nlm.nih.gov/40255404/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,42774471,ER-Localized Deadenylase &lt;i&gt;PNLDC1&lt;/i&gt; Suppresses Colorectal Cancer Progression by Targeting the mRNA Decay of &lt;i&gt;TUBB4B&lt;/i&gt;.,2026,10.1002/exp2.70222,https://pubmed.ncbi.nlm.nih.gov/42774471/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,42625859,"Dysregulation of piRNA biogenesis-associated proteins in cancer: mechanisms, evidence, and translational constraints.",2026,10.3389/fmolb.2026.1906635,https://pubmed.ncbi.nlm.nih.gov/42625859/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,42530569,Integrated Ultrasound Localization Microscopy and Multi-Omics for Mechanism-Driven Stratification of Azoospermia.,2026,10.1177/15579883261468072,https://pubmed.ncbi.nlm.nih.gov/42530569/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,41059337,Cracking the code: how piRNA pathway shapes spermatogenesis and combats male infertility.,2025,10.3389/fcell.2025.1657744,https://pubmed.ncbi.nlm.nih.gov/41059337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,42074016,A Whole-Exome Sequencing-Based Exploration of Chronic Kidney Disease of Unknown Etiology (CKDu) in an Endemic Population in Sri Lanka.,2026,10.3390/ijms27083369,https://pubmed.ncbi.nlm.nih.gov/42074016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,40852913,Novel PNLDC1 mutations underlie nonobstructive azoospermia in humans and mice.,2025,10.1093/hmg/ddaf136,https://pubmed.ncbi.nlm.nih.gov/40852913/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,39312580,"PNLDC1 catalysis and postnatal germline function are required for piRNA trimming, LINE1 silencing, and spermatogenesis in mice.",2024,10.1371/journal.pgen.1011429,https://pubmed.ncbi.nlm.nih.gov/39312580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,39943208,Identified Candidate Genes of Semen Trait in Three Pig Breeds Through Weighted GWAS and Multi-Tissue Transcriptome Analysis.,2025,10.3390/ani15030438,https://pubmed.ncbi.nlm.nih.gov/39943208/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,41401169,Diagnostic yield of exome sequencing in nonobstructive azoospermia (NOA): A systematic review and meta-analysis.,2025,10.1371/journal.pone.0338892,https://pubmed.ncbi.nlm.nih.gov/41401169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,34347949,"Variant PNLDC1, Defective piRNA Processing, and Azoospermia.",2021,10.1056/nejmoa2028973,https://pubmed.ncbi.nlm.nih.gov/34347949/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,36960498,A novel loss-of-function variant in PNLDC1 inducing oligo-astheno-teratozoospermia and male infertility.,2023,10.4103/aja20233,https://pubmed.ncbi.nlm.nih.gov/36960498/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,37282384,The role of homozygous LOF variant of the PNLDC1 gene in oligo-astheno-teratozoospermia (OAT) and male infertility.,2023,10.4103/aja202322,https://pubmed.ncbi.nlm.nih.gov/37282384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,41663928,Genome-wide association analysis to identify candidate genes for growth rate traits in Chinese endemic geese.,2026,10.1186/s12864-026-12518-z,https://pubmed.ncbi.nlm.nih.gov/41663928/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,32486081,PIWIL3 Forms a Complex with TDRKH in Mammalian Oocytes.,2020,10.3390/cells9061356,https://pubmed.ncbi.nlm.nih.gov/32486081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,29018194,PNLDC1 is essential for piRNA 3' end trimming and transposon silencing during spermatogenesis in mice.,2017,10.1038/s41467-017-00854-4,https://pubmed.ncbi.nlm.nih.gov/29018194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,36263612,How genetic defects in piRNA trimming contribute to male infertility.,2023,10.1111/andr.13324,https://pubmed.ncbi.nlm.nih.gov/36263612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,28994417,An essential role for PNLDC1 in piRNA 3' end trimming and male fertility in mice.,2017,10.1038/cr.2017.125,https://pubmed.ncbi.nlm.nih.gov/28994417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,35361267,A risk model of gene signatures for predicting platinum response and survival in ovarian cancer.,2022,10.1186/s13048-022-00969-3,https://pubmed.ncbi.nlm.nih.gov/35361267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,29444933,"PNLDC1, mouse pre-piRNA Trimmer, is required for meiotic and post-meiotic male germ cell development.",2018,10.15252/embr.201744957,https://pubmed.ncbi.nlm.nih.gov/29444933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,35116519,Construction of a prognostic risk model of colorectal adenocarcinoma through integrated analysis of RNA-binding proteins.,2021,10.21037/tcr-21-40,https://pubmed.ncbi.nlm.nih.gov/35116519/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNLDC1,ENSG00000146453,Unsafe,34080453,RNA Binding Protein-Based Model for Prognostic Prediction of Colorectal Cancer.,2021,10.1177/15330338211019504,https://pubmed.ncbi.nlm.nih.gov/34080453/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNMA5,ENSG00000198883,Unsafe,40784167,"USP22-mediated PNMA5 deubiquitination promotes proliferation, migration and invasion of prostate cancer cells.",2025,10.1016/j.acthis.2025.152279,https://pubmed.ncbi.nlm.nih.gov/40784167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNMA5,ENSG00000198883,Unsafe,41308389,Platycodin D inhibits non-small cell lung cancer bone metastasis by inducing ferroptosis through miR-877-3P/PNMA5 regulatory axis.,2025,10.1016/j.phymed.2025.157534,https://pubmed.ncbi.nlm.nih.gov/41308389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNMA5,ENSG00000198883,Unsafe,40539460,Comprehensive &lt;i&gt;in‑silico&lt;/i&gt; molecular analysis of early‑onset gastric cancer identifies novel genes implicated in disease characterization and progression (Review).,2025,10.3892/or.2025.8931,https://pubmed.ncbi.nlm.nih.gov/40539460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNMA5,ENSG00000198883,Unsafe,39101471,Evolution of Virus-like Features and Intrinsically Disordered Regions in Retrotransposon-derived Mammalian Genes.,2024,10.1093/molbev/msae154,https://pubmed.ncbi.nlm.nih.gov/39101471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNMA5,ENSG00000198883,Unsafe,35559417,"PNMA5 accelerated cellular proliferation, invasion and migration in colorectal cancer.",2022,,https://pubmed.ncbi.nlm.nih.gov/35559417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNMA5,ENSG00000198883,Unsafe,35117731,"PNMA5 knockdown suppresses the proliferation, invasion, and metastasis of epithelial ovarian cancer cells.",2020,10.21037/tcr-20-2013,https://pubmed.ncbi.nlm.nih.gov/35117731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNMA5,ENSG00000198883,Unsafe,34136487,PNMA5 Promotes Bone Metastasis of Non-small-Cell Lung Cancer as a Target of BMP2 Signaling.,2021,10.3389/fcell.2021.678931,https://pubmed.ncbi.nlm.nih.gov/34136487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNMA5,ENSG00000198883,Unsafe,37240180,Multi-Omics Data Integration Reveals Key Variables Contributing to Subgingival Microbiome Dysbiosis-Induced Inflammatory Response in a Hyperglycemic Microenvironment.,2023,10.3390/ijms24108832,https://pubmed.ncbi.nlm.nih.gov/37240180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNMA5,ENSG00000198883,Unsafe,32626960,Bioinformatic analysis of the potential molecular mechanism of PAK7 expression in glioblastoma.,2020,10.3892/mmr.2020.11206,https://pubmed.ncbi.nlm.nih.gov/32626960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNMA5,ENSG00000198883,Unsafe,29228573,Pnma5 is essential to the progression of meiosis in mouse oocytes through a chain of phosphorylation.,2017,10.18632/oncotarget.18425,https://pubmed.ncbi.nlm.nih.gov/29228573/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNMA5,ENSG00000198883,Unsafe,27424190,"Distinct functional domains of PNMA5 mediate protein-protein interaction, nuclear localization, and apoptosis signaling in human cancer cells.",2016,10.1007/s00432-016-2205-5,https://pubmed.ncbi.nlm.nih.gov/27424190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNMA5,ENSG00000198883,Unsafe,19366867,Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner.,2009,10.1093/cercor/bhp062,https://pubmed.ncbi.nlm.nih.gov/19366867/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PNMA5,ENSG00000198883,Unsafe,30884206,Candidate genes involved in metastasis of colon cancer identified by integrated analysis.,2019,10.1002/cam4.2071,https://pubmed.ncbi.nlm.nih.gov/30884206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,42877237,Pan-cancer multi-omics analysis reveals upregulation of the POLE2 subunit of DNA polymerase epsilon and its associations with patient survival and cellular pathways beyond DNA replication.,2026,10.1093/nargab/lqag118,https://pubmed.ncbi.nlm.nih.gov/42877237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,42773249,POLE2 of tumor cells promotes OPN secretion based on PCLAF to drive M2 macrophage polarization in clear cell renal cell carcinoma.,2026,10.1038/s41417-026-01083-y,https://pubmed.ncbi.nlm.nih.gov/42773249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,41893924,"Role of POLE2/GINS1-mediated AKT/mTOR pathway in RCC autophagy, proliferation, and metastasis: evidences from bioinformatic, clinical, and experimental data.",2026,10.1007/s10495-025-02206-w,https://pubmed.ncbi.nlm.nih.gov/41893924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,39155507,POLE2 silencing inhibits the progression of colorectal carcinoma cells via wnt signaling axis.,2024,10.1080/15384047.2024.2392339,https://pubmed.ncbi.nlm.nih.gov/39155507/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,41390769,The non-catalytic DNA polymerase ε subunit is an NPF motif recognition protein.,2025,10.1038/s41467-025-67284-5,https://pubmed.ncbi.nlm.nih.gov/41390769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,41284119,The analysis of TOP2A as a potential target for predicting the prognosis of brain glioma in the TCGA database and in single-center study.,2025,10.1007/s12672-025-04051-4,https://pubmed.ncbi.nlm.nih.gov/41284119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,38627379,POLE2 promotes osteosarcoma progression by enhancing the stability of CD44.,2024,10.1038/s41420-024-01875-x,https://pubmed.ncbi.nlm.nih.gov/38627379/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,40081544,"GINS4 silencing mediates hepatocellular cancer cell proliferation, cycle and ferroptosis through POLE2.",2025,10.1016/j.cellsig.2025.111742,https://pubmed.ncbi.nlm.nih.gov/40081544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,41614789,Integrative Bioinformatics and Experimental Validation Establish CCNB1 as a Potential Biomarker for Diagnosis and Prognosis in Colorectal Cancer.,2025,10.3390/cimb47121026,https://pubmed.ncbi.nlm.nih.gov/41614789/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,39813918,Transcriptome analysis reveals the DNA replication genes response to Vibrio anguillarum and NNV infection in Jinhu grouper (Epinephelus fuscoguttatus♀ × Epinephelus tukulal♂).,2025,10.1016/j.cbd.2025.101421,https://pubmed.ncbi.nlm.nih.gov/39813918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,38079056,POLE2 Regulates Apoptosis of Oral Squamous Cell Carcinoma Cells through the PI3K/AKT Signaling Pathway.,2023,10.1007/s11596-023-2813-7,https://pubmed.ncbi.nlm.nih.gov/38079056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,38370377,Prognostic and chemotherapeutic response prediction by proliferation essential gene signature: Investigating POLE2 in bladder cancer progression and cisplatin resistance.,2024,10.7150/jca.93023,https://pubmed.ncbi.nlm.nih.gov/38370377/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,38070189,Inhibition of ferroptosis by POLE2 in gastric cancer cells involves the activation of NRF2/GPX4 pathway.,2024,10.1111/jcmm.17983,https://pubmed.ncbi.nlm.nih.gov/38070189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,39056538,Simultaneous knockout of cytosolic and plastidial disproportionating enzymes disrupts grain setting and filling in rice.,2024,10.1093/plphys/kiae398,https://pubmed.ncbi.nlm.nih.gov/39056538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,37733085,Silencing POLE2 promotes apoptosis and inhibits proliferation of oral squamous cell carcinomas by inhibiting PI3K/AKT signaling pathway.,2023,10.1007/s12032-023-02158-8,https://pubmed.ncbi.nlm.nih.gov/37733085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,38734676,Characterization of alternative splicing events and prognostic signatures in gastric cancer.,2024,10.1186/s12935-024-03348-8,https://pubmed.ncbi.nlm.nih.gov/38734676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,37097331,POLE2 knockdown suppresses lymphoma progression via downregulating Wnt/β-catenin signaling pathway.,2024,10.1007/s11010-023-04738-8,https://pubmed.ncbi.nlm.nih.gov/37097331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,39811603,Functional Analysis and Experimental Validation of the Prognostic and Immune Effects of the Oncogenic Protein CDC45 in Breast Cancer.,2025,10.2147/bctt.s497975,https://pubmed.ncbi.nlm.nih.gov/39811603/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,41831914,Root inoculation with Trichoderma harzianum primes metabolic and stress-response pathways underlying growth and resistance in Brassica rapa.,2026,10.1016/j.pestbp.2026.107053,https://pubmed.ncbi.nlm.nih.gov/41831914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,41760274,Concurrent Pemetrexed With EGFR-TKI Slows the Accumulation of &lt;i&gt;De Novo&lt;/i&gt; Mutations During &lt;i&gt;In Vitro&lt;/i&gt; Exposure.,2026,10.21873/anticanres.18032,https://pubmed.ncbi.nlm.nih.gov/41760274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,40961586,"Design, synthesis and biological evaluation of magnolol-sulforaphane hybrid analogues as potential therapeutics of triple-negative breast cancer.",2025,10.1016/j.ejmech.2025.118136,https://pubmed.ncbi.nlm.nih.gov/40961586/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,37746978,Effects of dural puncture epidural technique with different drug delivery methods for labor analgesia: A randomized controlled clinical trial.,2023,10.1097/md.0000000000035217,https://pubmed.ncbi.nlm.nih.gov/37746978/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,37915460,The Evaluation of Prognostic Value and Immune Characteristics of Ferroptosis-Related Genes in Lung Squamous Cell Carcinoma.,2023,10.1055/s-0043-1776386,https://pubmed.ncbi.nlm.nih.gov/37915460/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,38103068,BLCA prognostic model creation and validation based on immune gene-metabolic gene combination.,2023,10.1007/s12672-023-00853-6,https://pubmed.ncbi.nlm.nih.gov/38103068/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,37240068,Bioinformatics Identification of Regulatory Genes and Mechanism Related to Hypoxia-Induced PD-L1 Inhibitor Resistance in Hepatocellular Carcinoma.,2023,10.3390/ijms24108720,https://pubmed.ncbi.nlm.nih.gov/37240068/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,35173608,Berberine Inhibits FOXM1 Dependent Transcriptional Regulation of POLE2 and Interferes With the Survival of Lung Adenocarcinoma.,2021,10.3389/fphar.2021.775514,https://pubmed.ncbi.nlm.nih.gov/35173608/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,40224989,The identification and prediction of lung adenocarcinoma prognosis using a novel gene signature associated with DNA replication.,2025,10.21037/tcr-2024-2536,https://pubmed.ncbi.nlm.nih.gov/40224989/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,32304567,POLE2 Serves as a Prognostic Biomarker and Is Associated with Immune Infiltration in Squamous Cell Lung Cancer.,2020,10.12659/msm.921430,https://pubmed.ncbi.nlm.nih.gov/32304567/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,30132567,Knockdown of POLE2 expression suppresses lung adenocarcinoma cell malignant phenotypes in vitro.,2018,10.3892/or.2018.6659,https://pubmed.ncbi.nlm.nih.gov/30132567/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,26365386,A novel mutation in the POLE2 gene causing combined immunodeficiency.,2016,10.1016/j.jaci.2015.06.049,https://pubmed.ncbi.nlm.nih.gov/26365386/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,36371178,Molecular subtyping based on TRP family and prognostic assessment for TRP-associated lncRNAs in pancreatic adenocarcinoma.,2022,10.1186/s12876-022-02552-y,https://pubmed.ncbi.nlm.nih.gov/36371178/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,32161100,CHK1 Inhibition Is Synthetically Lethal with Loss of B-Family DNA Polymerase Function in Human Lung and Colorectal Cancer Cells.,2020,10.1158/0008-5472.can-19-1372,https://pubmed.ncbi.nlm.nih.gov/32161100/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,31798600,Maltose Processing and Not β-Amylase Activity Curtails Hydrolytic Starch Degradation in the CAM Orchid Phalaenopsis.,2019,10.3389/fpls.2019.01386,https://pubmed.ncbi.nlm.nih.gov/31798600/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,30763339,Ectopic Otoconin 90 expression in triple negative breast cancer cell lines is associated with metastasis functions.,2019,10.1371/journal.pone.0211737,https://pubmed.ncbi.nlm.nih.gov/30763339/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLE2,ENSG00000100479,Unsafe,35175191,Whole transcriptome analysis of platelet concentrates during storage.,2023,10.2450/2022.0291-21,https://pubmed.ncbi.nlm.nih.gov/35175191/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,42608614,"Immunohistochemical expression of JAK2, STAT3, POLH, UBE2T, and REV7 in serous ovarian carcinoma: clinicopathological associations and co-expression patterns.",2026,10.1007/s10735-026-10944-7,https://pubmed.ncbi.nlm.nih.gov/42608614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,42310649,"Genomic characterization of a baculovirus isolate, Malacosoma neustria nucleopolyhedrovirus Eriogaster neogena isolate (ManeNPV-Er) from Mongolia.",2026,10.1186/s12985-026-03225-y,https://pubmed.ncbi.nlm.nih.gov/42310649/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,40966519,Translesion DNA polymerases Rev1 and PolH promote LTR-retrotransposon transcription by safeguarding Pol II occupancy in both germline and somatic tissues of Drosophila.,2025,10.1093/nar/gkaf903,https://pubmed.ncbi.nlm.nih.gov/40966519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,41253828,Characterization of dual DNA polymerase knockout strains of Candida albicans with live whole-cell vaccine competence.,2025,10.1038/s41541-025-01291-x,https://pubmed.ncbi.nlm.nih.gov/41253828/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,42510809,Epigenetics and DNA Base Substitutions of Epstein-Barr Virus (EBV)-Related Gastric Cancers: Implications for Targeted Therapies.,2026,10.3390/genes17070769,https://pubmed.ncbi.nlm.nih.gov/42510809/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,39242532,Comprehensive analysis of POLH-AS1 as a prognostic biomarker in hepatocellular carcinoma.,2024,10.1186/s12885-024-12857-8,https://pubmed.ncbi.nlm.nih.gov/39242532/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,42122158,Genome-Scale CRISPR Screens Reveal DNA Repair Dependencies That Sensitize Hepatocellular Carcinoma to Oxaliplatin.,2026,10.3390/cancers18091360,https://pubmed.ncbi.nlm.nih.gov/42122158/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,40334807,"Four germline POLH variants, including two found in skin tumors, impair DNA polymerase η function and cellular tolerance to UV radiation and cisplatin.",2025,10.1016/j.cbi.2025.111551,https://pubmed.ncbi.nlm.nih.gov/40334807/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,41074151,"Identification of radiation-sensitive genes as biomarkers for biodosimetry: an ex vivo analysis of TNFRSF10B, ZMAT3, POLH, and PLK2 in human blood samples.",2025,10.1186/s12920-025-02209-1,https://pubmed.ncbi.nlm.nih.gov/41074151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,41164819,Epitranscriptome-wide profiling identifies RNA editing events regulated by ADAR1 that are associated with DNA repair mechanisms in human TK6 cells.,2025,10.3389/fgene.2025.1663827,https://pubmed.ncbi.nlm.nih.gov/41164819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,41315479,Germline variants of the POLH and RAD51 genes are candidate variants associated with risk of hormone receptor-negative young-onset breast cancer.,2025,10.1038/s41523-025-00848-2,https://pubmed.ncbi.nlm.nih.gov/41315479/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,41762288,Doxorubicin induces immediate transcriptional change and apoptosis in spermatogonia from prepubertal rats.,2026,10.1007/s00204-026-04325-y,https://pubmed.ncbi.nlm.nih.gov/41762288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,40192296,Specific nucleotide substitutions in the burst sequence enhance &lt;i&gt;polyhedrin&lt;/i&gt; expression in alphabaculoviruses: improvement of baculovirus expression vectors.,2025,10.1128/aem.00144-25,https://pubmed.ncbi.nlm.nih.gov/40192296/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,42561022,Polymerase ι promotes C&gt;T substitutions in smoking models and in the platinum chemotherapy-induced SBS31 mutation signature.,2026,10.1073/pnas.2526551123,https://pubmed.ncbi.nlm.nih.gov/42561022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,41913195,A prognostic model utilizing disulfidptosis-related long noncoding RNAs to differentiate pathological grades in hepatocellular carcinoma: functional analysis of AL031985.3.,2026,10.1186/s12957-026-04311-9,https://pubmed.ncbi.nlm.nih.gov/41913195/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,42436856,Engineering inter-promoter spacing in baculovirus dual-expression systems enhances transcription and reduces rAAV2 empty capsids.,2026,10.1016/j.omta.2026.201792,https://pubmed.ncbi.nlm.nih.gov/42436856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,40769549,[Expression pattern of polyhedrin of BmNPV and involvement of importin α in the nuclear import of Polh].,2025,10.13345/j.cjb.240613,https://pubmed.ncbi.nlm.nih.gov/40769549/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,38724003,Codon Optimization-based Whole-gene Scanning Identifies Hidden Nucleotides Essential for Bombyx mori Nucleopolyhedrovirus polyhedrin Hyperexpression.,2024,10.1016/j.jmb.2024.168595,https://pubmed.ncbi.nlm.nih.gov/38724003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,39339951,"Tuning VSV-G Expression Improves Baculovirus Integrity, Stability and Mammalian Cell Transduction Efficiency.",2024,10.3390/v16091475,https://pubmed.ncbi.nlm.nih.gov/39339951/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,38765049,Basement membrane-related lncRNA signature for the prognosis of hepatocellular carcinoma.,2024,10.1016/j.heliyon.2024.e30439,https://pubmed.ncbi.nlm.nih.gov/38765049/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,41711921,"Occlusion body-incorporated SARS-CoV-2 S-RBD via cypovirus polyhedrin-derived peptide: a novel insect cell-expressed antigen for high-accuracy COVID-19 diagnosis, and humoral immune response and hybrid immunity evaluation.",2026,10.1590/s1678-9946202668012,https://pubmed.ncbi.nlm.nih.gov/41711921/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,38558246,Long noncoding RNA TUG1 promotes cisplatin resistance in ovarian cancer via upregulation of DNA polymerase eta.,2024,10.1111/cas.16150,https://pubmed.ncbi.nlm.nih.gov/38558246/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,40992406,Investigation of radiation-induced DNA damage repair-related genes as diagnostic biomarkers for radiation.,2025,10.1093/jrr/rraf057,https://pubmed.ncbi.nlm.nih.gov/40992406/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,37770477,A novel signature for predicting prognosis and immune landscape in cutaneous melanoma based on anoikis-related long non-coding RNAs.,2023,10.1038/s41598-023-39837-5,https://pubmed.ncbi.nlm.nih.gov/37770477/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,38006465,Prognostic Signature Constructed of Seven Ferroptosis-Related lncRNAs Predicts the Prognosis of HBV-Related HCC.,2024,10.1007/s12029-023-00977-6,https://pubmed.ncbi.nlm.nih.gov/38006465/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,33923836,Incidence of Carassius auratus Gibelio Gill Hemorrhagic Disease Caused by CyHV-2 Infection Can Be Reduced by Vaccination with Polyhedra Incorporating Antigens.,2021,10.3390/vaccines9040397,https://pubmed.ncbi.nlm.nih.gov/33923836/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,36634904,Exploring pradimicin-IRD antineoplastic mechanisms and related DNA repair pathways.,2023,10.1016/j.cbi.2023.110342,https://pubmed.ncbi.nlm.nih.gov/36634904/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,39237917,Prognostic value of nucleotide excision repair and translesion DNA synthesis proteins in muscle-infiltrating bladder carcinoma.,2024,10.1186/s12885-024-12865-8,https://pubmed.ncbi.nlm.nih.gov/39237917/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLH,ENSG00000170734,Unsafe,36369058,Identification and validation of cuproptosis-related LncRNA signatures as a novel prognostic model for head and neck squamous cell cancer.,2022,10.1186/s12935-022-02762-0,https://pubmed.ncbi.nlm.nih.gov/36369058/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,42769851,DNA Polymerase θ Drives Colorectal Cancer Progression through Wnt/β-Catenin Activation and Shows Potential Association with Immunosuppressive Microenvironment Remodeling.,2026,10.32604/or.2026.080204,https://pubmed.ncbi.nlm.nih.gov/42769851/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,42480518,Disruption of microhomology-mediated end joining in Ewing sarcoma.,2026,10.1016/j.molcel.2026.06.038,https://pubmed.ncbi.nlm.nih.gov/42480518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,41823540,POLQ promotes tumor progression and immunosuppression via ATM‑P53 signaling in endometrial cancer.,2026,10.3892/or.2026.9097,https://pubmed.ncbi.nlm.nih.gov/41823540/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,41645172,Targeted suppression of DNA polymerase θ enhances calcium flux and triggers intrinsic apoptosis in gastric cancer.,2026,10.1186/s12935-026-04206-5,https://pubmed.ncbi.nlm.nih.gov/41645172/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,42578367,Sam68 stimulates polymerase theta-mediated end-joining by suppressing poison exon inclusion in Polq mRNA.,2026,10.1093/nar/gkag783,https://pubmed.ncbi.nlm.nih.gov/42578367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,42608614,"Immunohistochemical expression of JAK2, STAT3, POLH, UBE2T, and REV7 in serous ovarian carcinoma: clinicopathological associations and co-expression patterns.",2026,10.1007/s10735-026-10944-7,https://pubmed.ncbi.nlm.nih.gov/42608614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,42700780,Genomic signatures of the Arctic-adapted North American gray wolf ecotype.,2026,10.1016/j.ygeno.2026.111315,https://pubmed.ncbi.nlm.nih.gov/42700780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,42781707,Integrating single-cell multi-omics for precision radiotherapy stratification in hypopharyngeal squamous cell carcinoma.,2026,10.3389/fgene.2026.1932515,https://pubmed.ncbi.nlm.nih.gov/42781707/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,42540301,Combining Artificial Intelligence and Human Expertise in Pursuit of Novel PolQ Inhibitors.,2026,10.1021/acsomega.6c01170,https://pubmed.ncbi.nlm.nih.gov/42540301/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,42748573,The emerging landscape of polymerase θ in tumor pathogenesis and precision treatment.,2026,10.1016/j.bbrc.2026.154593,https://pubmed.ncbi.nlm.nih.gov/42748573/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,42656196,PCNA-RECQL5-RPRD1B recruit repair components to stressed replication forks to promote survival of BRCA1-deficient cancer cells.,2026,10.1093/nar/gkag831,https://pubmed.ncbi.nlm.nih.gov/42656196/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,42310649,"Genomic characterization of a baculovirus isolate, Malacosoma neustria nucleopolyhedrovirus Eriogaster neogena isolate (ManeNPV-Er) from Mongolia.",2026,10.1186/s12985-026-03225-y,https://pubmed.ncbi.nlm.nih.gov/42310649/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,40966519,Translesion DNA polymerases Rev1 and PolH promote LTR-retrotransposon transcription by safeguarding Pol II occupancy in both germline and somatic tissues of Drosophila.,2025,10.1093/nar/gkaf903,https://pubmed.ncbi.nlm.nih.gov/40966519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,41982723,The Potential of DNA Polymerase Theta (POLQ) Inhibitors as Cancer Therapy for Homologous Recombination (HR)-Deficient Tumors.,2026,10.1021/acsmedchemlett.6c00135,https://pubmed.ncbi.nlm.nih.gov/41982723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,40482467,POLQ mediated end-joining promotes DNA damage tolerance in neuroblastoma.,2025,10.1016/j.tranon.2025.102433,https://pubmed.ncbi.nlm.nih.gov/40482467/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,39520627,"POLQ knockdown inhibits proliferation, migration, and invasion by inducing cell cycle arrest in colorectal cancer.",2024,10.1007/s12672-024-01496-x,https://pubmed.ncbi.nlm.nih.gov/39520627/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,42600026,Defective microhomology-mediated end joining in &lt;i&gt;SMARCB1&lt;/i&gt;-deficient tumors.,2026,10.1126/sciadv.aed7743,https://pubmed.ncbi.nlm.nih.gov/42600026/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,40082407,FAN1-mediated translesion synthesis and POLQ/HELQ-mediated end joining generate interstrand crosslink-induced mutations.,2025,10.1038/s41467-025-57764-z,https://pubmed.ncbi.nlm.nih.gov/40082407/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,42510809,Epigenetics and DNA Base Substitutions of Epstein-Barr Virus (EBV)-Related Gastric Cancers: Implications for Targeted Therapies.,2026,10.3390/genes17070769,https://pubmed.ncbi.nlm.nih.gov/42510809/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,42451670,Overcoming Resistance in Triple-Negative Breast Cancer: A Translational Perspective on Next-Generation DNA Damage Response Inhibitors and Synthetic Lethality.,2026,10.3390/molecules31132303,https://pubmed.ncbi.nlm.nih.gov/42451670/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,42727625,Synthetic lethality and context-selective DNA-damage response dependencies: from genetic vulnerability to pharmacological translation.,2026,10.1016/j.drudis.2026.104803,https://pubmed.ncbi.nlm.nih.gov/42727625/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,38457207,POLQ identifies a better response subset to immunotherapy in muscle-invasive bladder cancer with high PD-L1.,2024,10.1002/cam4.6962,https://pubmed.ncbi.nlm.nih.gov/38457207/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,41315479,Germline variants of the POLH and RAD51 genes are candidate variants associated with risk of hormone receptor-negative young-onset breast cancer.,2025,10.1038/s41523-025-00848-2,https://pubmed.ncbi.nlm.nih.gov/41315479/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,42762135,Beyond poly(ADP-ribose) polymerase inhibition: emerging therapeutic strategies for germline BRCA1/2 -mutated and PALB2 -mutated breast cancers.,2026,10.1097/cco.0000000000001275,https://pubmed.ncbi.nlm.nih.gov/42762135/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,39242532,Comprehensive analysis of POLH-AS1 as a prognostic biomarker in hepatocellular carcinoma.,2024,10.1186/s12885-024-12857-8,https://pubmed.ncbi.nlm.nih.gov/39242532/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,41669101,Targeted gene sequencing and bioinformatics analysis of a patient with gallbladder adenosquamous carcinoma: a case report.,2026,10.3389/fonc.2026.1697015,https://pubmed.ncbi.nlm.nih.gov/41669101/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,40334807,"Four germline POLH variants, including two found in skin tumors, impair DNA polymerase η function and cellular tolerance to UV radiation and cisplatin.",2025,10.1016/j.cbi.2025.111551,https://pubmed.ncbi.nlm.nih.gov/40334807/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,39435280,POLQ immunostaining behaves as a prognostic factor for pancreatic carcinoma.,2024,10.3389/fonc.2024.1433179,https://pubmed.ncbi.nlm.nih.gov/39435280/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,40664653,Refined DNA repair manipulation enables a universal knock-in strategy in mouse embryos.,2025,10.1038/s41467-025-61696-z,https://pubmed.ncbi.nlm.nih.gov/40664653/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,39122831,Polθ: emerging synthetic lethal partner in homologous recombination-deficient tumors.,2024,10.1038/s41417-024-00815-2,https://pubmed.ncbi.nlm.nih.gov/39122831/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLQ,ENSG00000051341,Unsafe,14576298,"POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells.",2003,10.1093/nar/gkg814,https://pubmed.ncbi.nlm.nih.gov/14576298/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLR2M,ENSG00000255529,Unsafe,40778374,Unveiling histotype-specific biomarkers in ovarian carcinoma using proteomics.,2025,10.1016/j.omton.2025.201019,https://pubmed.ncbi.nlm.nih.gov/40778374/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLR2M,ENSG00000255529,Unsafe,38985658,Dominant suppressor genes of p53-induced apoptosis in Drosophila melanogaster.,2024,10.1093/g3journal/jkae149,https://pubmed.ncbi.nlm.nih.gov/38985658/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLR2M,ENSG00000255529,Unsafe,34741119,The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis.,2022,10.1038/s41375-021-01461-5,https://pubmed.ncbi.nlm.nih.gov/34741119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLR2M,ENSG00000255529,Unsafe,34899865,"GRINL1A Complex Transcription Unit Containing GCOM1, MYZAP, and POLR2M Genes Associates with Fully Penetrant Recessive Dilated Cardiomyopathy.",2021,10.3389/fgene.2021.786705,https://pubmed.ncbi.nlm.nih.gov/34899865/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLR2M,ENSG00000255529,Unsafe,22850672,Regulation of mammalian transcription by Gdown1 through a novel steric crosstalk revealed by cryo-EM.,2012,10.1038/emboj.2012.205,https://pubmed.ncbi.nlm.nih.gov/22850672/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLR2M,ENSG00000255529,Unsafe,22244332,Transcriptional regulation by Pol II(G) involving mediator and competitive interactions of Gdown1 and TFIIF with Pol II.,2012,10.1016/j.molcel.2011.12.014,https://pubmed.ncbi.nlm.nih.gov/22244332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLR2M,ENSG00000255529,Unsafe,22244331,Functional association of Gdown1 with RNA polymerase II poised on human genes.,2012,10.1016/j.molcel.2011.10.022,https://pubmed.ncbi.nlm.nih.gov/22244331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POLR2M,ENSG00000255529,Unsafe,15233991,"The human GRINL1A gene defines a complex transcription unit, an unusual form of gene organization in eukaryotes.",2004,10.1016/j.ygeno.2004.04.004,https://pubmed.ncbi.nlm.nih.gov/15233991/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POTEG,ENSG00000187537,Unsafe,29566278,Down-regulation of POTEG predicts poor prognosis in esophageal squamous cell carcinoma patients.,2018,10.1002/mc.22809,https://pubmed.ncbi.nlm.nih.gov/29566278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,42492831,Targeting tumor cell-intrinsic POU4F1 enhances antitumor immunity and sensitizes tumors to immunotherapy in basal-like breast cancer by modulating macrophage recruitment and polarization.,2026,10.1016/j.canlet.2026.218763,https://pubmed.ncbi.nlm.nih.gov/42492831/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,42853007,"Spontaneous Achromatopsia-Like Phenotype in Albino Swiss CD-1 Mice: Retinocortical Dysfunction, Neurovascular Remodeling, and Glial Activation.",2026,10.1167/iovs.67.12.20,https://pubmed.ncbi.nlm.nih.gov/42853007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,41723941,"Generation of the induced pluripotent stem cell line ISMMSi061-A from a patient with ataxia, intention tremor, and hypotonia syndrome, childhood-onset.",2026,10.1016/j.scr.2026.103938,https://pubmed.ncbi.nlm.nih.gov/41723941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,42041682,A Pan-Cancer Transcriptomic Signature for Conserved Molecular Programs Underlying Premalignant-Malignant Progression Across Common Carcinomas.,2026,10.3390/dj14040228,https://pubmed.ncbi.nlm.nih.gov/42041682/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,42807766,Prognostic value of neuro-related genes in colorectal cancer and their potential implications for immunotherapy.,2026,10.7150/jca.136690,https://pubmed.ncbi.nlm.nih.gov/42807766/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,42390160,The Role of Nrf2 in SIRT1-Mediated RGC Neuroprotection in Traumatic Optic Neuropathy.,2026,10.1167/tvst.15.7.2,https://pubmed.ncbi.nlm.nih.gov/42390160/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,41158507,"Ataxia, intentional tremor and hypotonia syndrome caused by a novel &lt;i&gt;POU4F1&lt;/i&gt; gene mutation: a case report.",2025,10.3389/fgene.2025.1702803,https://pubmed.ncbi.nlm.nih.gov/41158507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,42743821,Bushen Mingmu Wan attenuates excitotoxic retinal injury and ferroptosis-associated pathology with involvement of CYP1B1-related PI3K/AKT signaling.,2026,10.1016/j.prp.2026.156691,https://pubmed.ncbi.nlm.nih.gov/42743821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,40251903,Integrated quantitative proteomics and phosphoproteomics analysis reveals USP46-POU4F1-HPSE signaling axis in the pathogenesis of Hirschsprung disease.,2025,10.3724/abbs.2025064,https://pubmed.ncbi.nlm.nih.gov/40251903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,41025963,POU4F1 Promotes the Primary Resistance of Melanoma to Anti-PD-1 Therapy by Regulating Glycolysis Through METTL1-Mediated m7G Methylation of PKM2.,2025,10.1002/mc.70049,https://pubmed.ncbi.nlm.nih.gov/41025963/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,39715266,"Runx3, Brn3a and Isl1 interplay orchestrates the transcriptional program in the early stages of proprioceptive neuron development.",2024,10.1371/journal.pgen.1011401,https://pubmed.ncbi.nlm.nih.gov/39715266/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,40122823,"Deubiquitinase USP18 mediates cell migration, apoptosis and ferroptosis in lung adenocarcinoma by depending on POU4F1/PRKAA2 axis.",2025,10.1186/s12885-025-13869-8,https://pubmed.ncbi.nlm.nih.gov/40122823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,42872745,Retinal Ganglion Cell Quantification for Evaluating Neurodegeneration in Mouse Models of Multiple Sclerosis​.,2026,10.3791/72666,https://pubmed.ncbi.nlm.nih.gov/42872745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,42293987,Extracellular vesicles subpopulation derived of clonal mesenchymal stem cells protected retinal ganglion cells in mouse model with optic nerve crush.,2026,10.1016/j.reth.2026.101145,https://pubmed.ncbi.nlm.nih.gov/42293987/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,42281784,Intravitreal delivery of NGF-chitosan hydrogel confers retinal ganglion cell protection and visual function recovery in experimental glaucoma.,2026,10.1016/j.bioactmat.2026.04.037,https://pubmed.ncbi.nlm.nih.gov/42281784/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,42258424,Repetitive hypoxic preconditioning protects retinal ganglion cells against damage caused by exposure to blast.,2026,10.1371/journal.pone.0349124,https://pubmed.ncbi.nlm.nih.gov/42258424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,39676891,POU4F1 enhances lung cancer gemcitabine resistance by regulating METTL3-dependent TWF1 mRNA N6 adenosine methylation.,2025,10.1007/s13205-024-04161-w,https://pubmed.ncbi.nlm.nih.gov/39676891/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,40996939,"POU4F1 Drives Colorectal Cancer Progression by Promoting Cell Proliferation, Metastasis, and Chemoresistance.",2026,10.1159/000548266,https://pubmed.ncbi.nlm.nih.gov/40996939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,42309337,Optimizing NGN2 Dosage Enhances the Neuronal Enrichment of iPSC-Derived Neuronal Cultures.,2026,10.1016/j.mcpro.2026.101604,https://pubmed.ncbi.nlm.nih.gov/42309337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,41982463,Analysis of retinal ganglion cell subtypes across six different inbred mouse strains.,2026,,https://pubmed.ncbi.nlm.nih.gov/41982463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,41566423,Genome-wide identification of SNPs related to resistance to soybean stem canker caused by Diaporthe caulivora.,2026,10.1186/s12870-025-07812-z,https://pubmed.ncbi.nlm.nih.gov/41566423/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,41113993,AIF1L as a Ferroptosis-Linked Biomarker in Microsatellite States-Driven Colorectal Cancer: Functional and Diagnostic Insights From Multiomics Analysis.,2025,10.1155/humu/6663166,https://pubmed.ncbi.nlm.nih.gov/41113993/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,42872951,Neuroprotective and Anti-Inflammatory Effects of SOCS1 Mimetic Peptides in Mouse Diabetic Retinopathy.,2026,10.1167/iovs.67.12.21,https://pubmed.ncbi.nlm.nih.gov/42872951/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,39551902,Role of cow dung and sawdust during the bioconversion of swine waste through the rotary drum composting process.,2024,10.1007/s10661-024-13395-3,https://pubmed.ncbi.nlm.nih.gov/39551902/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,39757274,Integrated singlecell and bulk RNA-seq analysis identifies a prognostic signature related to inflammation in colorectal cancer.,2025,10.1038/s41598-024-84998-6,https://pubmed.ncbi.nlm.nih.gov/39757274/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,39749343,A novel liquid-liquid phase separation-related gene signature for predicting prognosis in colon cancer.,2024,10.3389/fimmu.2024.1514613,https://pubmed.ncbi.nlm.nih.gov/39749343/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,38962013,Identifying and evaluating a disulfidptosis-related gene signature to predict prognosis in colorectal adenocarcinoma patients.,2024,10.3389/fimmu.2024.1344637,https://pubmed.ncbi.nlm.nih.gov/38962013/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,38891043,Cytoprotective Small Compound M109S Attenuated Retinal Ganglion Cell Degeneration Induced by Optic Nerve Crush in Mice.,2024,10.3390/cells13110911,https://pubmed.ncbi.nlm.nih.gov/38891043/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,41226841,Therapeutic Modulation of the Nox2-Hv1-ROS Axis by Botulinum Neurotoxin A Confers Protection Against CoCl&lt;sub&gt;2&lt;/sub&gt;-Induced Retinal Hypoxic Injury.,2025,10.3390/ijms262110806,https://pubmed.ncbi.nlm.nih.gov/41226841/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,36176299,Development of an exosome-related and immune microenvironment prognostic signature in colon adenocarcinoma.,2022,10.3389/fgene.2022.995644,https://pubmed.ncbi.nlm.nih.gov/36176299/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,7623109,"The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons.",1995,10.1523/jneurosci.15-07-04762.1995,https://pubmed.ncbi.nlm.nih.gov/7623109/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU4F1,ENSG00000152192,Unsafe,1357630,A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system.,1992,10.1093/nar/20.18.4919,https://pubmed.ncbi.nlm.nih.gov/1357630/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU5F2,ENSG00000248483,Unsafe,42228999,Comparative analysis of mesenchymal stromal cells derived from ovarian follicular aspirates of young and aged mares.,2026,10.1016/j.theriogenology.2026.118003,https://pubmed.ncbi.nlm.nih.gov/42228999/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU5F2,ENSG00000248483,Unsafe,9849898,Functional heterodimeric amino acid transporters lacking cysteine residues involved in disulfide bond.,1998,10.1016/s0014-5793(98)01359-3,https://pubmed.ncbi.nlm.nih.gov/9849898/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU5F2,ENSG00000248483,Unsafe,9751058,Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family.,1998,10.1038/26246,https://pubmed.ncbi.nlm.nih.gov/9751058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU5F2,ENSG00000248483,Unsafe,17545149,Amino acid transport in schistosomes: Characterization of the permeaseheavy chain SPRM1hc.,2007,10.1074/jbc.m703512200,https://pubmed.ncbi.nlm.nih.gov/17545149/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
POU5F2,ENSG00000248483,Unsafe,7908264,"A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues.",1994,10.1111/j.1432-1033.1994.tb18676.x,https://pubmed.ncbi.nlm.nih.gov/7908264/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,42494120,FgCot1 Regulates Polarized Growth and Conidiation in Fusarium graminearum via Gpmk1 MAPK and Tsf1 Transcriptional Pathways.,2026,10.1111/mpp.70321,https://pubmed.ncbi.nlm.nih.gov/42494120/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,41455833,NAT10 triggers colorectal cancer progression via promoting PPAN-regulated DNA damage repair.,2026,10.1038/s41388-025-03661-0,https://pubmed.ncbi.nlm.nih.gov/41455833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,42541528,Muse cell transplantation attenuates neuroinflammation and preserves endothelial reparative responses after radiation-induced brain injury.,2026,10.1177/09636897261474028,https://pubmed.ncbi.nlm.nih.gov/42541528/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,39386105,PPAN modulates mouse male germ cell development via maintaining nucleolar homeostasis.,2025,10.1016/j.gendis.2024.101204,https://pubmed.ncbi.nlm.nih.gov/39386105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,41522066,Improving cardiac computed tomography angiography image quality and diagnostic confidence for atrial fibrillation after left atrial appendage closure using a second-generation whole-heart motion correction algorithm.,2026,10.21037/qims-2025-689,https://pubmed.ncbi.nlm.nih.gov/41522066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,41623641,Development of a recombinase-aided isothermal amplification method coupled with a lateral flow dipstick assay for the diagnosis of powdery scab in potatoes.,2025,10.3389/fmicb.2025.1714852,https://pubmed.ncbi.nlm.nih.gov/41623641/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,42312489,rRNA intermediates associate with nucleolar reshaping in C. elegans.,2026,10.1093/nar/gkag598,https://pubmed.ncbi.nlm.nih.gov/42312489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,38794501,"Polymer Nanocomposite Based on Pyrolyzed Polyacrylonitrile Doped with Carbon Nanotubes: Synthesis, Properties, and Mechanism of Formation.",2024,10.3390/polym16101308,https://pubmed.ncbi.nlm.nih.gov/38794501/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,36679029,Variety-Specific Flowering of Sugarcane Induced by the Smut Fungus Sporisorium scitamineum.,2023,10.3390/plants12020316,https://pubmed.ncbi.nlm.nih.gov/36679029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,35554497,Ppan is essential for preimplantation development in mice†.,2022,10.1093/biolre/ioac098,https://pubmed.ncbi.nlm.nih.gov/35554497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,39108672,"Improving image quality and in-stent restenosis diagnosis with high-resolution ""double-low"" coronary CT angiography in patients after percutaneous coronary intervention.",2024,10.3389/fcvm.2024.1330824,https://pubmed.ncbi.nlm.nih.gov/39108672/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,38878080,Reduction of Helicobacter pylori cells in rural water supply using slow sand filtration.,2024,10.1007/s10661-024-12764-2,https://pubmed.ncbi.nlm.nih.gov/38878080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,34741342,An SNP reducing SNORD105 and PPAN expression decreases the risk of hepatocellular carcinoma in a Chinese population.,2021,10.1002/jcla.24095,https://pubmed.ncbi.nlm.nih.gov/34741342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,35472319,Upregulation of ribosome biogenesis via canonical E-boxes is required for Myc-driven proliferation.,2022,10.1016/j.devcel.2022.03.018,https://pubmed.ncbi.nlm.nih.gov/35472319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,37450438,Human nucleolar protein SURF6/RRP14 participates in early steps of pre-rRNA processing.,2023,10.1371/journal.pone.0285833,https://pubmed.ncbi.nlm.nih.gov/37450438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,31416196,Loss of Peter Pan (PPAN) Affects Mitochondrial Homeostasis and Autophagic Flux.,2019,10.3390/cells8080894,https://pubmed.ncbi.nlm.nih.gov/31416196/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,38058237,Defective kernel 58 encodes an Rrp15p domain-containing protein essential to ribosome biogenesis and seed development in maize.,2024,10.1111/nph.19460,https://pubmed.ncbi.nlm.nih.gov/38058237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,35270759,"The COVID-19 Pandemic and Levels of Physical Activity in the Last Trimester, Life Satisfaction and Perceived Stress in Late Pregnancy and in the Early Puerperium.",2022,10.3390/ijerph19053066,https://pubmed.ncbi.nlm.nih.gov/35270759/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,36767219,"The Impact of the COVID-19 Pandemic on the Level of Physical Activity, Emotional State, and Health Habits of Women in Late Pregnancy and Early Puerperium.",2023,10.3390/ijerph20031852,https://pubmed.ncbi.nlm.nih.gov/36767219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,36531250,Identification and validation of a prognostic model based on ferroptosis-associated genes in head and neck squamous cancer.,2022,10.3389/fgene.2022.1065546,https://pubmed.ncbi.nlm.nih.gov/36531250/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,39324663,Nonsolvent-Induced Phase Separation pPAN Separators for Dendrite-Free Rechargeable Aluminum Batteries.,2024,10.1021/acsami.4c03746,https://pubmed.ncbi.nlm.nih.gov/39324663/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,38630628,Selenium-Doped Sulfurized Polyacrylonitrile Hybrid Cathodes with Ultrahigh Sulfur Content for High-Performance Solid-State Lithium Sulfur Batteries.,2024,10.1021/acs.langmuir.4c00682,https://pubmed.ncbi.nlm.nih.gov/38630628/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,31713966,Prospect of Sulfurized Pyrolyzed Poly(acrylonitrile) (S@pPAN) Cathode Materials for Rechargeable Lithium Batteries.,2020,10.1002/anie.201913540,https://pubmed.ncbi.nlm.nih.gov/31713966/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,32715361,"Increased RNA production in Saccharomyces cerevisiae by simultaneously overexpressing FHL1, IFH1, and SSF2 and deleting HRP1.",2020,10.1007/s00253-020-10784-9,https://pubmed.ncbi.nlm.nih.gov/32715361/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,32286042,Material and Interfacial Modification toward a Stable Room-Temperature Solid-State Na-S Battery.,2020,10.1021/acsami.0c03899,https://pubmed.ncbi.nlm.nih.gov/32286042/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,29888331,A pyrolyzed polyacrylonitrile/selenium disulfide composite cathode with remarkable lithium and sodium storage performances.,2018,10.1126/sciadv.aat1687,https://pubmed.ncbi.nlm.nih.gov/29888331/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,32444848,"Prediction of breast cancer proteins involved in immunotherapy, metastasis, and RNA-binding using molecular descriptors and artificial neural networks.",2020,10.1038/s41598-020-65584-y,https://pubmed.ncbi.nlm.nih.gov/32444848/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,35056614,It Works! Organic-Waste-Assisted Trichoderma spp. Solid-State Fermentation on Agricultural Digestate.,2022,10.3390/microorganisms10010164,https://pubmed.ncbi.nlm.nih.gov/35056614/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,31187886,Identification of genes and pathways in human antigen-presenting cell subsets in response to polio vaccine by bioinformatical analysis.,2019,10.1002/jmv.25514,https://pubmed.ncbi.nlm.nih.gov/31187886/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,31960936,Computational systems biology as an animal-free approach to characterize toxicological effects of persistent organic pollutants.,2020,10.14573/altex.1910161,https://pubmed.ncbi.nlm.nih.gov/31960936/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,25759387,The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway.,2015,10.1074/jbc.m114.634246,https://pubmed.ncbi.nlm.nih.gov/25759387/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,32310638,Stable Lithium Metal Anode Enabled by a Lithiophilic and Electron/Ion Conductive Framework.,2020,10.1021/acsnano.9b10083,https://pubmed.ncbi.nlm.nih.gov/32310638/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,25669430,EIF3G is associated with narcolepsy across ethnicities.,2015,10.1038/ejhg.2015.4,https://pubmed.ncbi.nlm.nih.gov/25669430/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,23139860,Inexpensive method for producing macroporous silicon particulates (MPSPs) with pyrolyzed polyacrylonitrile for lithium ion batteries.,2012,10.1038/srep00795,https://pubmed.ncbi.nlm.nih.gov/23139860/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,11278528,Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes.,2001,10.1074/jbc.m009609200,https://pubmed.ncbi.nlm.nih.gov/11278528/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAN,ENSG00000130810,Unsafe,10944437,"Cloning, genomic organization, and tissue distribution of human Ssf-1.",2000,10.1006/bbrc.2000.3259,https://pubmed.ncbi.nlm.nih.gov/10944437/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,42847799,Associations of periprostatic adipose tissue measures obtained post-androgen deprivation therapy with prostate tumor aggressiveness and gene expression profiles.,2026,10.1158/1055-9965.epi-26-0664,https://pubmed.ncbi.nlm.nih.gov/42847799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,42847696,Exploratory Analysis of Peri-Prostatic Adipose Tissue Radiomics Features and Their Potential to Predict Prostate Cancer Diagnosis: Results From a UK Biobank Study.,2026,10.1002/pros.70226,https://pubmed.ncbi.nlm.nih.gov/42847696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,42769124,Multiparametric MRI-based radiomics model integrating tumor lesion and periprostatic adipose tissue for predicting bone metastasis in prostate cancer.,2026,10.3389/fonc.2026.1918323,https://pubmed.ncbi.nlm.nih.gov/42769124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,42160481,Reduced Uncoupling Protein 1 Expression in Periprostatic Adipose Tissue and Its Association With Higher Prostate Cancer Grade.,2026,10.1111/iju.70506,https://pubmed.ncbi.nlm.nih.gov/42160481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,42588799,Identification and Functional Characterization of the GPAT Gene Family in Regulating Oil Biosynthesis in Olive.,2026,10.3390/plants15152295,https://pubmed.ncbi.nlm.nih.gov/42588799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,40660195,Advancing prostate cancer research: an exploration of periprostatic adipose stem cells.,2025,10.1186/s12967-025-06734-6,https://pubmed.ncbi.nlm.nih.gov/40660195/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,42874220,"Periprostatic adipose tissue imaging in prostate cancer: Imaging phenotypes, task-specific spatial strategies, and multicompartment integration-a critical review.",2026,10.1016/j.ejrad.2026.113296,https://pubmed.ncbi.nlm.nih.gov/42874220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,41559600,ppAT drives glutamine-dependent purine biosynthesis and malignant progression in hepatocellular carcinoma.,2026,10.1186/s12885-025-15512-y,https://pubmed.ncbi.nlm.nih.gov/41559600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,42135849,Periprostatic adipose tissue-derived adipokine profile in prostate cancer patients reveals two distinct molecular phenotypes linked to obesity-related comorbidities: multifaceted role of lipocalin-2.,2026,10.1186/s12964-026-02925-w,https://pubmed.ncbi.nlm.nih.gov/42135849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,42769216,Dual-region deep learning model integrating prostate and peri-prostatic adipose tissue MRI features for bone metastasis prediction in prostate cancer.,2026,10.3389/fonc.2026.1946971,https://pubmed.ncbi.nlm.nih.gov/42769216/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,41899551,Fibrosis of Periprostatic Adipose Tissue: A Potential Marker of Prostate Cancer Aggressiveness.,2026,10.3390/cancers18060949,https://pubmed.ncbi.nlm.nih.gov/41899551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,42231146,Normalized periprostatic adipose tissue thickness: an imaging marker associated with prostate biopsy outcomes among patients with PI-RADS and PSA double gray zone.,2026,10.1080/21623945.2026.2683754,https://pubmed.ncbi.nlm.nih.gov/42231146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,41835269,Genome-wide analysis of the &lt;i&gt;GPAT&lt;/i&gt; gene family in wheat and the potential roles of &lt;i&gt;TaGPAT58&lt;/i&gt; and its homologs in male reproductive development.,2026,10.3389/fpls.2026.1779919,https://pubmed.ncbi.nlm.nih.gov/41835269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,41554711,Glycerol 3-phosphate acyltransferase exacerbates α-synuclein-induced toxicity by increasing lipid peroxidation.,2026,10.1038/s41467-026-68325-3,https://pubmed.ncbi.nlm.nih.gov/41554711/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,42742857,mpMRI-based clinic-radiomics-deep learning model integrating lesion and PPAT for predicting csPCa in PI-RADS category 3 lesions: a multicenter study.,2026,10.1007/s11255-026-05396-7,https://pubmed.ncbi.nlm.nih.gov/42742857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,41440554,Obesogenic Dysregulation of Human Periprostatic Adipose Tissue Promotes the Viability of Prostate Cells and Reduces Their Sensitivity to Docetaxel and Cabazitaxel.,2025,10.3390/medsci13040322,https://pubmed.ncbi.nlm.nih.gov/41440554/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,41566212,Periprostatic adipose tissue-derived extracellular vesicles modulate prostate cancer cell behaviour in vitro according to tumour grade.,2026,10.1186/s10020-026-01422-7,https://pubmed.ncbi.nlm.nih.gov/41566212/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,39941741,Periprostatic Adipose Tissue as a Contributor to Prostate Cancer Pathogenesis: A Narrative Review.,2025,10.3390/cancers17030372,https://pubmed.ncbi.nlm.nih.gov/39941741/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,41715916,Extracellular matrix remodeling as a unique mechanism of expansion of periprostatic adipose tissue: implication for prostate cancer aggressiveness.,2026,10.1002/path.70033,https://pubmed.ncbi.nlm.nih.gov/41715916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,42268342,Decreasing S1PR3 Alleviated Renal Tubular Lipid Deposition in Diabetic Nephropathy via AMPK/PPAR-γ/GPAT3 Pathway.,2026,10.1007/s12010-026-05640-x,https://pubmed.ncbi.nlm.nih.gov/42268342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,42798353,Reactive agility training selectively improves choice reaction and footwork-stroke performance in young male table tennis players: a randomized controlled trial.,2026,10.3389/fphys.2026.1903033,https://pubmed.ncbi.nlm.nih.gov/42798353/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,42395285,Community engagement as a foundation for implementation research for group psilocybin assisted therapy in New Mexico.,2026,10.3389/fpubh.2026.1845943,https://pubmed.ncbi.nlm.nih.gov/42395285/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,41196949,NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT.,2025,10.1126/science.adx9717,https://pubmed.ncbi.nlm.nih.gov/41196949/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,42457960,Metabolite glues as a means of purine sensing and chemotherapeutic response.,2026,10.1038/s41586-026-10790-3,https://pubmed.ncbi.nlm.nih.gov/42457960/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,42129924,Preoperative dual-ROI mpMRI radiomics integrating intratumoral and periprostatic adipose tissue features with clinical factors for predicting positive surgical margins after radical prostatectomy.,2026,10.1186/s40644-026-01034-8,https://pubmed.ncbi.nlm.nih.gov/42129924/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,39825108,Construction of cuproptosis-related genes risk model predicts the prognosis of Uterine Corpus Endometrial Carcinoma.,2025,10.1038/s41598-025-86756-8,https://pubmed.ncbi.nlm.nih.gov/39825108/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,40687311,Psychosocial considerations in pediatric heart transplantation: Initial validation of the Pediatric Psychosocial Assessment Tool at a single center.,2025,10.1016/j.jhlto.2025.100319,https://pubmed.ncbi.nlm.nih.gov/40687311/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,40536175,A nomogram based on radiomic features from peri-prostatic adipose tissue for predicting bone metastasis in first-time diagnosed prostate cancer patients.,2025,10.1080/21623945.2025.2517583,https://pubmed.ncbi.nlm.nih.gov/40536175/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,41233602,Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis.,2025,10.1038/s42255-025-01419-2,https://pubmed.ncbi.nlm.nih.gov/41233602/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,41196952,A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis.,2025,10.1126/science.adv4257,https://pubmed.ncbi.nlm.nih.gov/41196952/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,40488042,First-Time Identification of the PPAT Protein as a Novel Antibacterial Target: Antimicrobial and Antioxidant Insights from E. purpurea.,2025,10.1021/acsomega.5c00273,https://pubmed.ncbi.nlm.nih.gov/40488042/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,39196700,Phosphoribosyl pyrophosphate amidotransferase: Novel biomarker and therapeutic target for nasopharyngeal carcinoma.,2024,10.1111/cas.16314,https://pubmed.ncbi.nlm.nih.gov/39196700/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,40790169,A novel composite index of PSA and periprostatic adipose tissue quantification for enhancing high-grade prostate cancer prediction.,2025,10.1186/s12894-025-01884-7,https://pubmed.ncbi.nlm.nih.gov/40790169/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,39735553,Multi-omics analysis-based clinical and functional significance of a novel prognostic and immunotherapeutic gene signature derived from amino acid metabolism pathways in lung adenocarcinoma.,2024,10.3389/fimmu.2024.1361992,https://pubmed.ncbi.nlm.nih.gov/39735553/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,40097378,Therapeutic targeting de novo purine biosynthesis driven by β-catenin-dependent PPAT upregulation in hepatoblastoma.,2025,10.1038/s41419-025-07502-6,https://pubmed.ncbi.nlm.nih.gov/40097378/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,41394399,Comprehensive analysis and validation of the prognostic significance of cuproptosis-related genes in rectal adenocarcinoma.,2025,10.3389/fcell.2025.1622829,https://pubmed.ncbi.nlm.nih.gov/41394399/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPAT,ENSG00000128059,Unsafe,8380692,Molecular cloning of human amidophosphoribosyltransferase.,1993,10.1006/bbrc.1993.1030,https://pubmed.ncbi.nlm.nih.gov/8380692/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,41986950,Integrated transcriptomic and metabolomic analyses reveal host-metabolite interactions underlying cloacal inflammation in laying Pekin ducks.,2026,10.5713/ab.260208,https://pubmed.ncbi.nlm.nih.gov/41986950/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,39550471,C. elegans PPEF-type phosphatase (Retinal degeneration C ortholog) functions in diverse classes of cilia to regulate nematode behaviors.,2024,10.1038/s41598-024-79057-z,https://pubmed.ncbi.nlm.nih.gov/39550471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,40662666,Adaptive laboratory-evolved MRSA with PPEF manifests cross-susceptibility to oxacillin and hypersensitivity to ciprofloxacin.,2025,10.1128/spectrum.02974-24,https://pubmed.ncbi.nlm.nih.gov/40662666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,40169586,Structural insights into the dual Ca&lt;sup&gt;2+&lt;/sup&gt;-sensor-mediated activation of the PPEF phosphatase family.,2025,10.1038/s41467-025-58261-z,https://pubmed.ncbi.nlm.nih.gov/40169586/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,39215110,Unveiling disulfidptosis-related biomarkers and predicting drugs in Alzheimer's disease.,2024,10.1038/s41598-024-70893-7,https://pubmed.ncbi.nlm.nih.gov/39215110/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,41500484,ERAPID: an end‑to‑end RNA‑seq analysis pipeline for integrative candidate biomarker discovery with applications to neuropsychiatric disorders.,2026,10.1016/j.ymeth.2026.01.001,https://pubmed.ncbi.nlm.nih.gov/41500484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,40005152,"Electrospun Poly(butylene 2,5-furanoate) and Poly(pentamethylene 2,5-furanoate) Mats: Structure-Property Relationships and Thermo-Mechanical and Biological Characterization.",2025,10.3390/molecules30040841,https://pubmed.ncbi.nlm.nih.gov/40005152/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,38784557,"TEC disturbances caused by CME-triggered geomagnetic storm of September 6-9, 2017.",2024,10.1016/j.heliyon.2024.e30725,https://pubmed.ncbi.nlm.nih.gov/38784557/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,36807602,Unraveling topoisomerase IA gate dynamics in presence of PPEF and its preclinical evaluation against multidrug-resistant pathogens.,2023,10.1038/s42003-023-04412-1,https://pubmed.ncbi.nlm.nih.gov/36807602/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,41374905,"Novel Superelastic Polyesters Based on 2,5-Furandicarboxylic Acid for Potential Use in Ophthalmic Surgery.",2025,10.3390/polym17233220,https://pubmed.ncbi.nlm.nih.gov/41374905/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,33783058,"The protein phosphatase with EF-hand domain 1 is a calmodulin-binding protein that interacts with proteins involved in sperm capacitation, binding to the zona pellucida, and motility.",2021,10.1002/mrd.23467,https://pubmed.ncbi.nlm.nih.gov/33783058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,40020793,Zhichuanling injection improves bronchial asthma by attenuation airway inflammation and epithelia-mesenchymal transition.,2025,10.1016/j.jep.2025.119540,https://pubmed.ncbi.nlm.nih.gov/40020793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,32021267,The Clinical Significance of PPEF1 as a Promising Biomarker and Its Potential Mechanism in Breast Cancer.,2020,10.2147/ott.s229432,https://pubmed.ncbi.nlm.nih.gov/32021267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,36976532,Implications of Pleural Fluid Composition in Persistent Pleural Effusion following Orthotopic Liver Transplant.,2023,10.3390/medsci11010024,https://pubmed.ncbi.nlm.nih.gov/36976532/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,35874675,Comprehensive Analyses of Immune Subtypes of Stomach Adenocarcinoma for mRNA Vaccination.,2022,10.3389/fimmu.2022.827506,https://pubmed.ncbi.nlm.nih.gov/35874675/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,35361846,Prognostic significance of AP-2α/γ targets as cancer therapeutics.,2022,10.1038/s41598-022-09494-1,https://pubmed.ncbi.nlm.nih.gov/35361846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,34964699,Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancer.,2022,10.1080/21655979.2021.2012316,https://pubmed.ncbi.nlm.nih.gov/34964699/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,31816601,Identification of molecular correlations of RBM8A with autophagy in Alzheimer's disease.,2019,10.18632/aging.102571,https://pubmed.ncbi.nlm.nih.gov/31816601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,28051100,Protein serine/threonine phosphatase PPEF-1 suppresses genotoxic stress response via dephosphorylation of PDCD5.,2017,10.1038/srep39222,https://pubmed.ncbi.nlm.nih.gov/28051100/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,28303897,Synergistic efficacy of Bisbenzimidazole and Carbonyl Cyanide 3-Chlorophenylhydrazone combination against MDR bacterial strains.,2017,10.1038/srep44419,https://pubmed.ncbi.nlm.nih.gov/28303897/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,41150331,Eco-Friendly Membrane Separators Based on Furanoate Polymers for Li-Ion Batteries.,2025,10.3390/polym17202790,https://pubmed.ncbi.nlm.nih.gov/41150331/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,22292511,Molecular cloning of a novel PPEF-1 gene variant from a T-cell lymphoblastic lymphoma cell line.,2012,10.2174/187221512799303172,https://pubmed.ncbi.nlm.nih.gov/22292511/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,19662497,PPEF/PP7 protein Ser/Thr phosphatases.,2009,10.1007/s00018-009-0110-7,https://pubmed.ncbi.nlm.nih.gov/19662497/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,26202100,Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer's disease.,2015,10.1038/srep12393,https://pubmed.ncbi.nlm.nih.gov/26202100/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,17169445,Kinetoplastid PPEF phosphatases: dual acylated proteins expressed in the endomembrane system of Leishmania.,2007,10.1016/j.molbiopara.2006.11.008,https://pubmed.ncbi.nlm.nih.gov/17169445/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,10692750,Cefaclor af versus amoxycillin/clavulanate in acute bacterial exacerbations of chronic bronchitis: a randomised multicentre study.,1999,,https://pubmed.ncbi.nlm.nih.gov/10692750/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF1,ENSG00000086717,Unsafe,9430683,"Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC).",1998,10.1074/jbc.273.3.1462,https://pubmed.ncbi.nlm.nih.gov/9430683/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF2,ENSG00000156194,Unsafe,39277761,Umbilical cord blood-derived exosomes attenuate dopaminergic neuron damage of Parkinson's disease mouse model.,2024,10.1186/s12951-024-02773-1,https://pubmed.ncbi.nlm.nih.gov/39277761/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF2,ENSG00000156194,Unsafe,39550471,C. elegans PPEF-type phosphatase (Retinal degeneration C ortholog) functions in diverse classes of cilia to regulate nematode behaviors.,2024,10.1038/s41598-024-79057-z,https://pubmed.ncbi.nlm.nih.gov/39550471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF2,ENSG00000156194,Unsafe,30809231,Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells.,2019,10.3389/fimmu.2019.00222,https://pubmed.ncbi.nlm.nih.gov/30809231/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF2,ENSG00000156194,Unsafe,33270085,The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer.,2021,10.1042/bsr20203282,https://pubmed.ncbi.nlm.nih.gov/33270085/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF2,ENSG00000156194,Unsafe,31934309,Novel eye genes systematically discovered through an integrated analysis of mouse transcriptomes and phenome.,2020,10.1016/j.csbj.2019.12.009,https://pubmed.ncbi.nlm.nih.gov/31934309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF2,ENSG00000156194,Unsafe,31750736,Genetic Polymorphisms on 4q21.1 Contributed to the Risk of Hashimoto's Thyroiditis.,2019,10.1089/gtmb.2019.0125,https://pubmed.ncbi.nlm.nih.gov/31750736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF2,ENSG00000156194,Unsafe,20674765,Protein phosphatase with EF-hand domains 2 (PPEF2) is a potent negative regulator of apoptosis signal regulating kinase-1 (ASK1).,2010,10.1016/j.biocel.2010.07.014,https://pubmed.ncbi.nlm.nih.gov/20674765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF2,ENSG00000156194,Unsafe,24964093,Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation.,2014,10.1371/journal.pone.0099716,https://pubmed.ncbi.nlm.nih.gov/24964093/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF2,ENSG00000156194,Unsafe,21659543,Comparative promoter analysis in vivo: identification of a dendritic cell-specific promoter module.,2011,10.1182/blood-2011-03-342261,https://pubmed.ncbi.nlm.nih.gov/21659543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPEF2,ENSG00000156194,Unsafe,20664637,Kinase/phosphatase overexpression reveals pathways regulating hippocampal neuron morphology.,2010,10.1038/msb.2010.52,https://pubmed.ncbi.nlm.nih.gov/20664637/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,42409251,Loss of ETV4 triggers PPM1E downregulation and AMPK-ULK1-dependent autophagy to promote intrinsic trametinib resistance in breast cancer.,2026,10.1016/j.phrs.2026.108334,https://pubmed.ncbi.nlm.nih.gov/42409251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,42252159,"Expression of concern: ""Ppm1E is an in cellulo AMP-activated protein kinase phosphatase"" [Cellular Signalling, Volume 23, Issue 1, January 2011, Pages 114-124].",2026,10.1016/j.cellsig.2026.112581,https://pubmed.ncbi.nlm.nih.gov/42252159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,42334621,Genetic-epigenetic interactions (meQTLs) in orofacial clefts etiology.,2026,10.1007/s00438-026-02474-4,https://pubmed.ncbi.nlm.nih.gov/42334621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,38948282,"[miR-342-3p Promotes the Proliferation, Migration, and Invasion of Clear Cell Renal Cell Carcinoma Cells by Targeted Inhibition of PPM1E].",2024,10.12182/20240560403,https://pubmed.ncbi.nlm.nih.gov/38948282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,37766305,The DACH1 Gene Transcriptional Activation and Protein Degradation Mediated by Transactivator Tas of Prototype Foamy Virus.,2023,10.3390/v15091899,https://pubmed.ncbi.nlm.nih.gov/37766305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,36662636,Reduced Expression Level of Protein Phosphatase PPM1E Serves to Maintain Insulin Secretion in Type 2 Diabetes.,2023,10.2337/db22-0472,https://pubmed.ncbi.nlm.nih.gov/36662636/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,35368894,"LINC01087 Promotes the Proliferation, Migration, and Invasion of Thyroid Cancer Cells by Upregulating PPM1E.",2022,10.1155/2022/7787378,https://pubmed.ncbi.nlm.nih.gov/35368894/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,40437627,Transcriptomic analysis of transformed small-cell lung cancer from EGFR-mutated lung adenocarcinoma reveals distinct subgroups and precision therapy opportunities.,2025,10.1186/s40364-025-00789-9,https://pubmed.ncbi.nlm.nih.gov/40437627/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,38995776,Screening Targets and Therapeutic Drugs for Alzheimer's Disease Based on Deep Learning Model and Molecular Docking.,2024,10.3233/jad-231389,https://pubmed.ncbi.nlm.nih.gov/38995776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,34556632,"CircHAS2 promotes the proliferation, migration, and invasion of gastric cancer cells by regulating PPM1E mediated by hsa-miR-944.",2021,10.1038/s41419-021-04158-w,https://pubmed.ncbi.nlm.nih.gov/34556632/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,35132916,Inhibition of cell proliferation by Tas of foamy viruses through cell cycle arrest or apoptosis underlines the different mechanisms of virus-host interactions.,2022,10.1080/21505594.2022.2029329,https://pubmed.ncbi.nlm.nih.gov/35132916/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,29317228,Functions and dysfunctions of Ca2+/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) and CaMKP-N/PPM1E.,2018,10.1016/j.abb.2018.01.001,https://pubmed.ncbi.nlm.nih.gov/29317228/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,28423719,AMPKα phosphatase Ppm1E upregulation in human gastric cancer is required for cell proliferation.,2017,10.18632/oncotarget.16126,https://pubmed.ncbi.nlm.nih.gov/28423719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,28460435,microRNA-135b expression silences Ppm1e to provoke AMPK activation and inhibit osteoblastoma cell proliferation.,2017,10.18632/oncotarget.15477,https://pubmed.ncbi.nlm.nih.gov/28460435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,32650009,"Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors.",2020,10.1016/j.pharmthera.2020.107622,https://pubmed.ncbi.nlm.nih.gov/32650009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,32796585,Comparing Gene Expression in the Parabrachial and Amygdala of Diestrus and Proestrus Female Rats after Orofacial Varicella Zoster Injection.,2020,10.3390/ijms21165749,https://pubmed.ncbi.nlm.nih.gov/32796585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,27661114,miR-135b expression downregulates Ppm1e to activate AMPK signaling and protect osteoblastic cells from dexamethasone.,2016,10.18632/oncotarget.12138,https://pubmed.ncbi.nlm.nih.gov/27661114/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,29435120,AMPK activation by Tanshinone IIA protects neuronal cells from oxygen-glucose deprivation.,2018,10.18632/oncotarget.23391,https://pubmed.ncbi.nlm.nih.gov/29435120/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,27793001,miR-135b-5p inhibits LPS-induced TNFα production via silencing AMPK phosphatase Ppm1e.,2016,10.18632/oncotarget.12866,https://pubmed.ncbi.nlm.nih.gov/27793001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,32221048,Whole-transcriptome analysis reveals a potential hsa_circ_0001955/hsa_circ_0000977-mediated miRNA-mRNA regulatory sub-network in colorectal cancer.,2020,10.18632/aging.102945,https://pubmed.ncbi.nlm.nih.gov/32221048/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,30539815,Xiao-Xu-Ming decoction extract regulates differentially expressed proteins in the hippocampus after chronic cerebral hypoperfusion.,2019,10.4103/1673-5374.245471,https://pubmed.ncbi.nlm.nih.gov/30539815/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,23666239,Meta-analysis identifies four new loci associated with testicular germ cell tumor.,2013,10.1038/ng.2634,https://pubmed.ncbi.nlm.nih.gov/23666239/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1E,ENSG00000175175,Unsafe,22726253,Synergistic mechanism of gene expression and pathways between jasminoidin and ursodeoxycholic acid in treating focal cerebral ischemia-reperfusion injury.,2012,10.1111/j.1755-5949.2012.00348.x,https://pubmed.ncbi.nlm.nih.gov/22726253/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1J,ENSG00000155367,Unsafe,41361190,Microbiota-host crosstalk: the role of short-term dietary restriction in neurological and metabolic dysregulation.,2025,10.1038/s41522-025-00857-w,https://pubmed.ncbi.nlm.nih.gov/41361190/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1J,ENSG00000155367,Unsafe,39511232,PPM1J regulates meat quality feature and glycerophospholipids composition in broiler by modulating protein dephosphorylation.,2024,10.1038/s41538-024-00335-1,https://pubmed.ncbi.nlm.nih.gov/39511232/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1J,ENSG00000155367,Unsafe,38559895,Extracellular vesicles secreted by human aneuploid embryos present a distinct transcriptomic profile and upregulate MUC1 transcription in decidualised endometrial stromal cells.,2024,10.1093/hropen/hoae014,https://pubmed.ncbi.nlm.nih.gov/38559895/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1J,ENSG00000155367,Unsafe,34580980,Structural basis for the specificity of PPM1H phosphatase for Rab GTPases.,2021,10.15252/embr.202152675,https://pubmed.ncbi.nlm.nih.gov/34580980/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1J,ENSG00000155367,Unsafe,38490283,DNA methylation-altered genes in the rat hippocampal neurogenic niche after continuous exposure to amorphous curcumin.,2024,10.1016/j.jchemneu.2024.102414,https://pubmed.ncbi.nlm.nih.gov/38490283/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1J,ENSG00000155367,Unsafe,32650009,"Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors.",2020,10.1016/j.pharmthera.2020.107622,https://pubmed.ncbi.nlm.nih.gov/32650009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1J,ENSG00000155367,Unsafe,34723755,"Uncovering potential single nucleotide polymorphisms, copy number variations and related signaling pathways in primary Sjogren's syndrome.",2021,10.1080/21655979.2021.2000245,https://pubmed.ncbi.nlm.nih.gov/34723755/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1J,ENSG00000155367,Unsafe,31650199,Identification of prognostic genes in the acute myeloid leukemia immune microenvironment based on TCGA data analysis.,2019,10.1007/s00262-019-02408-7,https://pubmed.ncbi.nlm.nih.gov/31650199/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1J,ENSG00000155367,Unsafe,27920155,&lt;i&gt;SOS2&lt;/i&gt; and &lt;i&gt;ACP1&lt;/i&gt; Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function.,2017,10.1681/asn.2016020131,https://pubmed.ncbi.nlm.nih.gov/27920155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1J,ENSG00000155367,Unsafe,20865152,Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors.,2010,10.1371/journal.pcbi.1000908,https://pubmed.ncbi.nlm.nih.gov/20865152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPM1J,ENSG00000155367,Unsafe,40945087,Atrazine exposure induces skeletal muscle atrophy: Multi-omics insights into mechanisms and therapeutic targets.,2025,10.1016/j.ecoenv.2025.119044,https://pubmed.ncbi.nlm.nih.gov/40945087/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP1R2C,ENSG00000102055,Unsafe,24195737,Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes.,2013,10.1186/1471-2148-13-242,https://pubmed.ncbi.nlm.nih.gov/24195737/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP1R36,ENSG00000165807,Unsafe,41579373,Decoding the heterogeneity of human undifferentiated spermatogonia reveals RAS-dependent regulation of stem cell fate.,2026,10.1016/j.celrep.2025.116868,https://pubmed.ncbi.nlm.nih.gov/41579373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP1R36,ENSG00000165807,Unsafe,27098880,The germline-enriched Ppp1r36 promotes autophagy.,2016,10.1038/srep24609,https://pubmed.ncbi.nlm.nih.gov/27098880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP1R36,ENSG00000165807,Unsafe,31798171,Multi-trait genome-wide association study identifies new loci associated with optic disc parameters.,2019,10.1038/s42003-019-0634-9,https://pubmed.ncbi.nlm.nih.gov/31798171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP1R36,ENSG00000165807,Unsafe,31889064,Characterization and functional roles of paternal RNAs in 2-4 cell bovine embryos.,2019,10.1038/s41598-019-55868-3,https://pubmed.ncbi.nlm.nih.gov/31889064/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP1R36,ENSG00000165807,Unsafe,28374495,Genome-wide expression profiling and bioinformatics analysis of deregulated genes in human gastric cancer tissue after gastroscopy.,2018,10.1111/ajco.12688,https://pubmed.ncbi.nlm.nih.gov/28374495/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP1R42,ENSG00000178125,Unsafe,38835510,Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility.,2024,10.3389/fcell.2024.1411162,https://pubmed.ncbi.nlm.nih.gov/38835510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP1R42,ENSG00000178125,Unsafe,23718219,"PPP1R42, a PP1 binding protein, regulates centrosome dynamics in ARPE-19 cells.",2013,10.1111/boc.201300019,https://pubmed.ncbi.nlm.nih.gov/23718219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP1R42,ENSG00000178125,Unsafe,21738792,"PP1 forms an active complex with TLRR (lrrc67), a putative PP1 regulatory subunit, during the early stages of spermiogenesis in mice.",2011,10.1371/journal.pone.0021767,https://pubmed.ncbi.nlm.nih.gov/21738792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP1R42,ENSG00000178125,Unsafe,29141582,A novel interaction between kinase activities in regulation of cilia formation.,2017,10.1186/s12860-017-0149-5,https://pubmed.ncbi.nlm.nih.gov/29141582/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PPP1R42,ENSG00000178125,Unsafe,19886865,TLRR (lrrc67) interacts with PP1 and is associated with a cytoskeletal complex in the testis.,2010,10.1042/bc20090091,https://pubmed.ncbi.nlm.nih.gov/19886865/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,42858647,PRAP1 aggravates palmitate-induced insulin resistance in skeletal muscle cells through a CD36-dependent mechanism.,2026,10.1016/j.bbrc.2026.154722,https://pubmed.ncbi.nlm.nih.gov/42858647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,42765067,Transcriptomic trajectory of hepatocyte ballooning reveals a lipotoxic point of no return and initiates oncogenic regulatory rewiring in MASLD.,2026,10.1016/j.bbrep.2026.102785,https://pubmed.ncbi.nlm.nih.gov/42765067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,40563492,Estrogen-Regulated Proline-Rich Acidic Protein 1 in Endometrial Epithelial Cells Affects Embryo Implantation by Regulating Mucin 1 in Mice.,2025,10.3390/biom15060852,https://pubmed.ncbi.nlm.nih.gov/40563492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,40373840,PRAP1 regulates colorectal cancer cell proliferation and ferroptosis through the Nrf2 signaling pathway.,2025,10.1016/j.cellsig.2025.111863,https://pubmed.ncbi.nlm.nih.gov/40373840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,41807518,Dissecting the differentiation origins of intestinal metaplasia and early intestinal-type gastric cancer in gastric antrum by single-cell RNA profiling.,2026,10.1038/s41698-026-01355-8,https://pubmed.ncbi.nlm.nih.gov/41807518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,39095385,Single-cell RNA sequencing reveals placental response under environmental stress.,2024,10.1038/s41467-024-50914-9,https://pubmed.ncbi.nlm.nih.gov/39095385/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,40371706,scRNA-seq and scATAC-seq reveal that Sertoli cell mediates spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia.,2025,10.7554/elife.97958,https://pubmed.ncbi.nlm.nih.gov/40371706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,37325046,Proline-rich acidic protein 1 upregulates mitotic arrest deficient 1 to promote cisplatin-resistance of colorectal carcinoma by restraining mitotic checkpoint complex assembly.,2023,10.7150/jca.84048,https://pubmed.ncbi.nlm.nih.gov/37325046/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,38042368,Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion.,2024,10.1016/j.molmet.2023.101847,https://pubmed.ncbi.nlm.nih.gov/38042368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,38192816,ANP32B promotes colorectal cancer cell progression and reduces cell sensitivity to PRAP1 inhibitor through up-regulating HPF1.,2024,10.1016/j.heliyon.2023.e23829,https://pubmed.ncbi.nlm.nih.gov/38192816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,39950277,Discovery of the PARP1 Inhibitors from Natural Compounds Using Structure-Based Virtual Screening and Bioactivity Evaluation.,2026,10.2174/0115734064350048241121110017,https://pubmed.ncbi.nlm.nih.gov/39950277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,33168624,PRAP1 is a novel lipid-binding protein that promotes lipid absorption by facilitating MTTP-mediated lipid transport.,2021,10.1074/jbc.ra120.015002,https://pubmed.ncbi.nlm.nih.gov/33168624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,40152288,"The intracellular chylomicron highway: novel insights into chylomicron biosynthesis, trafficking, and secretion.",2025,10.1097/mol.0000000000000983,https://pubmed.ncbi.nlm.nih.gov/40152288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,32629119,Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis.,2020,10.1016/j.jcmgh.2020.06.011,https://pubmed.ncbi.nlm.nih.gov/32629119/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,37671310,Impact of Amplified Oncogenes on Salivary Gland Carcinomas.,2023,10.21873/cdp.10250,https://pubmed.ncbi.nlm.nih.gov/37671310/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,32871157,A Little Disorder Can Be Healthy: PRAP1 as a Protective Factor in the Intestine.,2020,10.1016/j.jcmgh.2020.08.001,https://pubmed.ncbi.nlm.nih.gov/32871157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,35967424,Immunosuppressive landscape in hepatocellular carcinoma revealed by single-cell sequencing.,2022,10.3389/fimmu.2022.950536,https://pubmed.ncbi.nlm.nih.gov/35967424/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,31660454,Proline-Rich Acidic Protein 1 (PRAP1) is a Target of ARID1A and PGR in the Murine Uterus.,2019,10.12717/dr.2019.23.3.277,https://pubmed.ncbi.nlm.nih.gov/31660454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,35978266,Adipocyte-Derived Exosomal MTTP Suppresses Ferroptosis and Promotes Chemoresistance in Colorectal Cancer.,2022,10.1002/advs.202203357,https://pubmed.ncbi.nlm.nih.gov/35978266/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,34957220,The Involvement of TRIB3 and FABP1 and Their Potential Functions in the Dynamic Process of Gastric Cancer.,2021,10.3389/fmolb.2021.790433,https://pubmed.ncbi.nlm.nih.gov/34957220/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,29922213,Nexilin Regulates Oligodendrocyte Progenitor Cell Migration and Remyelination and Is Negatively Regulated by Protease-Activated Receptor 1/Ras-Proximate-1 Signaling Following Subarachnoid Hemorrhage.,2018,10.3389/fneur.2018.00282,https://pubmed.ncbi.nlm.nih.gov/29922213/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,33057140,In vivo estrogenicity of p-phenoxyphenol and p-pentyloxyphenol.,2020,10.1038/s41598-020-73271-1,https://pubmed.ncbi.nlm.nih.gov/33057140/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,21540836,"Recognition and suppression of transfected plasmids by protein ZNF511-PRAP1, a potential molecular barrier to transgene expression.",2011,10.1038/mt.2011.80,https://pubmed.ncbi.nlm.nih.gov/21540836/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,24374861,Proline-rich acidic protein 1 (PRAP1) is a novel interacting partner of MAD1 and has a suppressive role in mitotic checkpoint signalling in hepatocellular carcinoma.,2014,10.1002/path.4319,https://pubmed.ncbi.nlm.nih.gov/24374861/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,20736409,Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.,2010,10.1074/mcp.m110.001719,https://pubmed.ncbi.nlm.nih.gov/20736409/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRAP1,ENSG00000165828,Unsafe,14583459,The proline-rich acidic protein is epigenetically regulated and inhibits growth of cancer cell lines.,2003,,https://pubmed.ncbi.nlm.nih.gov/14583459/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,41189817,"Analytical Review on Normal Brain Aging, Alzheimer's Disease, and Stage 4S Neuroblastoma: Novel Insights Into Neuroprotection, Neurodegeneration, and Spontaneous Regression.",2025,10.7759/cureus.93818,https://pubmed.ncbi.nlm.nih.gov/41189817/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,38364699,"Human PRH1, PRH2 susceptibility and resistance and Streptococcus mutans virulence phenotypes specify different microbial profiles in caries.",2024,10.1016/j.ebiom.2024.105001,https://pubmed.ncbi.nlm.nih.gov/38364699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,35076987,CircRNA PRH1-PRR4 stimulates RAB3D to regulate the malignant progression of NSCLC by sponging miR-877-5p.,2022,10.1111/1759-7714.14264,https://pubmed.ncbi.nlm.nih.gov/35076987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,38440359,Comparative analysis of paraspinal muscle imbalance between idiopathic scoliosis and congenital scoliosis from the transcriptome aspect.,2024,10.1002/jsp2.1318,https://pubmed.ncbi.nlm.nih.gov/38440359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,35330821,Gingival Transcriptome of Innate Antimicrobial Factors and the Oral Microbiome With Aging and Periodontitis.,2022,10.3389/froh.2022.817249,https://pubmed.ncbi.nlm.nih.gov/35330821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,36344085,The potential of a universal influenza virus-like particle vaccine expressing a chimeric cytokine.,2023,10.26508/lsa.202201548,https://pubmed.ncbi.nlm.nih.gov/36344085/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,32032352,PRH1 mediates ARF7-LBD dependent auxin signaling to regulate lateral root development in Arabidopsis thaliana.,2020,10.1371/journal.pgen.1008044,https://pubmed.ncbi.nlm.nih.gov/32032352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,36428492,Oncogenic Roles of Polycomb Repressive Complex 2 in Bladder Cancer and Upper Tract Urothelial Carcinoma.,2022,10.3390/biomedicines10112925,https://pubmed.ncbi.nlm.nih.gov/36428492/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,36077892,Salivary Gland Adaptation to Dietary Inclusion of Hydrolysable Tannins in Boars.,2022,10.3390/ani12172171,https://pubmed.ncbi.nlm.nih.gov/36077892/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,37627102,"Variant Characterization of a Representative Large Pedigree Suggests ""Variant Risk Clusters"" Convey Varying Predisposition of Risk to Lynch Syndrome.",2023,10.3390/cancers15164074,https://pubmed.ncbi.nlm.nih.gov/37627102/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,35845819,Comparative Response of HCC Cells to TKIs: Modified in vitro Testing and Descriptive Expression Analysis.,2022,10.2147/jhc.s356333,https://pubmed.ncbi.nlm.nih.gov/35845819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,36228679,"Salivary proteomic analysis in asymptomatic and symptomatic SARS-CoV-2 infection: Innate immunity, taste perception and FABP5 proteins make the difference.",2022,10.1016/j.cca.2022.09.023,https://pubmed.ncbi.nlm.nih.gov/36228679/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,29581444,Whole Genome Resequencing of Capsicum baccatum and Capsicum annuum to Discover Single Nucleotide Polymorphism Related to Powdery Mildew Resistance.,2018,10.1038/s41598-018-23279-5,https://pubmed.ncbi.nlm.nih.gov/29581444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,29191562,Genetic- and Lifestyle-dependent Dental Caries Defined by the Acidic Proline-rich Protein Genes PRH1 and PRH2.,2017,10.1016/j.ebiom.2017.11.019,https://pubmed.ncbi.nlm.nih.gov/29191562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,25761918,Chrono-proteomics of human saliva: variations of the salivary proteome during human development.,2015,10.1021/pr501270x,https://pubmed.ncbi.nlm.nih.gov/25761918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,9599313,Salivary acidic proline-rich proteins in rheumatoid arthritis.,1998,10.1111/j.1749-6632.1998.tb09651.x,https://pubmed.ncbi.nlm.nih.gov/9599313/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,8948367,Detection of HIV-1 infection with a green fluorescent protein reporter system.,1996,10.1097/00042560-199612010-00002,https://pubmed.ncbi.nlm.nih.gov/8948367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,2335371,"Salivary proline-rich protein polymorphisms in Chinese, Malays and Indians in Singapore.",1990,10.1159/000153912,https://pubmed.ncbi.nlm.nih.gov/2335371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,7983258,Human salivary acidic proline-rich protein polymorphisms and biosynthesis studied by high-performance liquid chromatography.,1994,10.1177/00220345940730110701,https://pubmed.ncbi.nlm.nih.gov/7983258/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRH1,ENSG00000231887,Unsafe,2171329,Alleles at the PRB3 locus coding for a disulfide-bonded human salivary proline-rich glycoprotein (Gl 8) and a null in an Ashkenazi Jew.,1990,,https://pubmed.ncbi.nlm.nih.gov/2171329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,42560969,Vitamin B12 combined with methylene blue alleviates experimental septic shock and is associated with modulation of KCNMB1 and the cGMP-PRKG pathway.,2026,10.1371/journal.pone.0355117,https://pubmed.ncbi.nlm.nih.gov/42560969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,42168243,Filamin-ETV4/5 acts as mechanosensor-mechanotransducer axis that drives cell competition-mediated elimination of transformed cells.,2026,10.1038/s41467-026-73504-3,https://pubmed.ncbi.nlm.nih.gov/42168243/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,41296694,A nonsense mutation in the PRKG2 gene in dalmatian dogs with chondrodysplasia.,2025,10.1371/journal.pone.0322107,https://pubmed.ncbi.nlm.nih.gov/41296694/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,41574272,Case Report: Dual pathogenic mechanism of a &lt;i&gt;PRKG2&lt;/i&gt; missense variant underlies an attenuated phenotype of acromesomelic dysplasia.,2025,10.3389/fgene.2025.1708985,https://pubmed.ncbi.nlm.nih.gov/41574272/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,39744538,Unveiling the shared genes between systemic sclerosis and lung cancer.,2024,10.3389/fmed.2024.1431642,https://pubmed.ncbi.nlm.nih.gov/39744538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,39202255,"ELOVL2, PRKG2, and EDARADD DNA Methylation Strongly Estimate Indonesian Adolescents.",2024,10.3390/diagnostics14161767,https://pubmed.ncbi.nlm.nih.gov/39202255/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,41473336,Study on the Therapeutic Effect and Mechanism of Gu Pi Sheng Ji Hua Zhuo Jie Du Decoction in Inducing Remission of Crohn's Disease.,2025,10.2147/ijgm.s538618,https://pubmed.ncbi.nlm.nih.gov/41473336/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,40887007,Microglial-derived nitric oxide regulates amygdala synaptic plasticity to drive chronic pain and depression induced by lumbar disc herniation.,2025,10.1016/j.neuropharm.2025.110662,https://pubmed.ncbi.nlm.nih.gov/40887007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,40551752,Investigating the Relationship between Ulcerative Colitis and Circadian Rhythm Genes Using Bioinformatics Analysis and Machine Learning.,2025,10.2147/ijgm.s521565,https://pubmed.ncbi.nlm.nih.gov/40551752/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,39757280,Regulator of G protein signaling-1 facilitates ovarian cancer development by modulating NF-kB signal pathway.,2025,10.1038/s41598-024-85071-y,https://pubmed.ncbi.nlm.nih.gov/39757280/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,40229590,Association of Lifestyle-Induced Weight Loss With Gene Expression in Subcutaneous Adipose Tissue in Metabolic Syndrome.,2025,10.1111/1753-0407.70083,https://pubmed.ncbi.nlm.nih.gov/40229590/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,37789084,"Two new patients with acromesomelic dysplasia, PRKG2 type-identification and characterization of the first missense variant.",2024,10.1038/s41431-023-01472-z,https://pubmed.ncbi.nlm.nih.gov/37789084/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,39525887,"Transcriptomics of Subcutaneous Tissue of Lipedema Identified Differentially Expressed Genes Involved in Adipogenesis, Inflammation, and Pain.",2024,10.1097/gox.0000000000006288,https://pubmed.ncbi.nlm.nih.gov/39525887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,35188962,Type-2 cGMP-dependent protein kinase suppresses proliferation and carcinogenesis in the colon epithelium.,2022,10.1093/carcin/bgac022,https://pubmed.ncbi.nlm.nih.gov/35188962/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,41375522,Overview of Donkey Welfare and Husbandry Practices in Asia.,2025,10.3390/ani15233464,https://pubmed.ncbi.nlm.nih.gov/41375522/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,39701680,[Molecular mechanism of Xiangsha Liujunzi Decoction in treating chronic atrophic gastritis based on transcriptome sequencing technology].,2024,10.19540/j.cnki.cjcmm.20240509.401,https://pubmed.ncbi.nlm.nih.gov/39701680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,40311511,Comprehensive transcriptome analysis and lncRNA-miRNA-mRNA establishment of schizophrenia based on induced pluripotent stem cells.,2025,10.1016/j.schres.2025.04.027,https://pubmed.ncbi.nlm.nih.gov/40311511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,36371651,Protein Kinase G2 Is Essential for Skeletal Homeostasis and Adaptation to Mechanical Loading in Male but Not Female Mice.,2023,10.1002/jbmr.4746,https://pubmed.ncbi.nlm.nih.gov/36371651/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,35313961,Prkg2 regulates alveolar type 2-mediated re-alveolarization.,2022,10.1186/s13287-022-02793-4,https://pubmed.ncbi.nlm.nih.gov/35313961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,36600198,Polymorphism detection of PRKG2 gene and its association with the number of thoracolumbar vertebrae and carcass traits in Dezhou donkey.,2023,10.1186/s12863-022-01101-6,https://pubmed.ncbi.nlm.nih.gov/36600198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,37453139,Transcriptomic analysis of ovarian follicles uncovers the crucial genes relevant to follicle selection and preovulatory hierarchy in hens.,2023,10.1093/jas/skad241,https://pubmed.ncbi.nlm.nih.gov/37453139/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,35782572,RNA Sequencing of the Pituitary Gland and Association Analyses Reveal PRKG2 as a Candidate Gene for Growth and Carcass Traits in Chinese Ningdu Yellow Chickens.,2022,10.3389/fvets.2022.892024,https://pubmed.ncbi.nlm.nih.gov/35782572/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,37579693,Chemical profiling and investigation of molecular mechanisms underlying anti-hepatocellular carcinoma activity of extracts from Polygonum perfoliatum L.,2023,10.1016/j.biopha.2023.115315,https://pubmed.ncbi.nlm.nih.gov/37579693/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,37522128,Identification of biomarkers associated with the invasion of nonfunctional pituitary neuroendocrine tumors based on the immune microenvironment.,2023,10.3389/fendo.2023.1131693,https://pubmed.ncbi.nlm.nih.gov/37522128/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,33374621,The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3-Deficient Mouse Model of Achromatopsia.,2020,10.3390/ijms22010052,https://pubmed.ncbi.nlm.nih.gov/33374621/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,32270922,Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease.,2020,10.15252/embr.201949783,https://pubmed.ncbi.nlm.nih.gov/32270922/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,39504828,Identification of SNPs and INDELS associated with duck egg quality traits through a genome-wide association analysis.,2024,10.1016/j.psj.2024.104459,https://pubmed.ncbi.nlm.nih.gov/39504828/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,38703453,Comprehensive analysis of differentially expressed mRNA profiles in chicken jejunum and cecum following Eimeria maxima infection.,2024,10.1016/j.psj.2024.103716,https://pubmed.ncbi.nlm.nih.gov/38703453/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,33405203,Identification of dysregulated pathways underlying HTLV-1-associated myelopathy/tropical spastic paraparesis through co-expression network analysis.,2021,10.1007/s13365-020-00919-z,https://pubmed.ncbi.nlm.nih.gov/33405203/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,32124961,Unraveling the genetic causes in large pedigrees with gout by whole‑exome sequencing.,2020,10.3892/ijmm.2020.4501,https://pubmed.ncbi.nlm.nih.gov/32124961/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRKG2,ENSG00000138669,Unsafe,27998725,cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium.,2017,10.1016/j.ajpath.2016.10.016,https://pubmed.ncbi.nlm.nih.gov/27998725/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,42682758,Decellularized testicular bio-scaffolds drive &lt;i&gt;in vitro&lt;/i&gt; differentiation of chemically reprogrammed fibroblasts.,2026,10.3389/fbioe.2026.1900213,https://pubmed.ncbi.nlm.nih.gov/42682758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,41393904,"Protamine1, 2 and Catsper1: sperm quality and fertility indicators in Stallions.",2025,10.1590/1984-3143-ar2025-0040,https://pubmed.ncbi.nlm.nih.gov/41393904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,42468500,Deciphering testicular aging through whole transcriptome sequencing and ceRNA network analysis in cattle.,2026,10.1016/j.theriogenology.2026.118089,https://pubmed.ncbi.nlm.nih.gov/42468500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,41595442,Nanopore Sequencing Technology Reveals the Transcriptional Expression Characteristics of Male Pig's Testes Before and After Sexual Maturity.,2025,10.3390/genes17010021,https://pubmed.ncbi.nlm.nih.gov/41595442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,41354937,Dynamic architecture of mammalian paternal chromatin: histone-to-protamine exchange and post-fertilization reprogramming.,2025,10.1186/s13072-025-00651-0,https://pubmed.ncbi.nlm.nih.gov/41354937/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,41046257,Protamine expression in somatic cells condenses chromatin and disrupts transcription without altering DNA methylation.,2025,10.1186/s13072-025-00633-2,https://pubmed.ncbi.nlm.nih.gov/41046257/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,42914668,Seminal extracellular vesicles improve cryosurvival and fertility potential of kundhi buffalo sperm.,2026,10.1016/j.theriogenology.2026.118278,https://pubmed.ncbi.nlm.nih.gov/42914668/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,42748838,Protamine gene expression is associated with sperm motility in rams: An integrative experimental and gene network analysis.,2026,10.1016/j.anireprosci.2026.108317,https://pubmed.ncbi.nlm.nih.gov/42748838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,41788348,Protamine-1 encoded recombinant adeno-associated virus for enhanced brain magnetic resonance imaging.,2026,10.1016/j.mrl.2025.200222,https://pubmed.ncbi.nlm.nih.gov/41788348/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,40755454,Protamine sequence determines species-specific nuclear shape and histone retention.,2025,10.1016/j.isci.2025.113102,https://pubmed.ncbi.nlm.nih.gov/40755454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,42038779,A Comparative Analysis of Culture Systems with Human Amniotic Mesenchymal Stem Cells.,2025,10.18502/jri.v26i4.21086,https://pubmed.ncbi.nlm.nih.gov/42038779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,42038776,Association of Circular RNAs with Sperm Fertility Potential: Implications for Male Infertility Diagnosis.,2025,10.18502/jri.v26i4.21087,https://pubmed.ncbi.nlm.nih.gov/42038776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,39187928,"Sperm RNA quantity and PRM1, PRM2 , and TH2B transcript levels reflect sperm characteristics and early embryonic development.",2025,10.4103/aja202452,https://pubmed.ncbi.nlm.nih.gov/39187928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,41397546,Research on the mechanism of Zuogui Wan in ameliorating oligoasthenozoospermia in rats via modulating cuproptosis-related pathways.,2026,10.1016/j.jep.2025.120990,https://pubmed.ncbi.nlm.nih.gov/41397546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,39386078,"""Protective effects of artichoke extract and Bifidobacterium longum on male infertility in diabetic rats"".",2024,10.1016/j.bbrep.2024.101834,https://pubmed.ncbi.nlm.nih.gov/39386078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,41923845,Proteome of the testicular cell-conditioned medium supports germ cell differentiation &lt;i&gt;in vitro&lt;/i&gt;.,2025,10.5455/javar.2025.1969,https://pubmed.ncbi.nlm.nih.gov/41923845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,40202661,High-Throughput Analysis of Postmeiotic Male Germ Cells Using Image Flow Cytometry.,2025,10.1007/978-1-0716-4406-5_38,https://pubmed.ncbi.nlm.nih.gov/40202661/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,40077949,Evaluation of &lt;i&gt;TNP1&lt;/i&gt; and &lt;i&gt;PRM1&lt;/i&gt; gene expression in male infertility patients with low or high sperm DNA fragmentation.,2025,10.4274/jtgga.galenos.2024.2024-5-3,https://pubmed.ncbi.nlm.nih.gov/40077949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,40714522,Comparative study of sperm protamine gene expression and chromatin integrity in Nellore and Angus bulls.,2025,10.1016/j.repbio.2025.101051,https://pubmed.ncbi.nlm.nih.gov/40714522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,40934633,"PRM1 modulates proliferation, apoptosis, and testosterone synthesis in bovine Leydig cells.",2025,10.1016/j.anireprosci.2025.107991,https://pubmed.ncbi.nlm.nih.gov/40934633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,36593375,Protamine 1 as a secreted colorectal cancer-specific antigen facilitating G1/S phase transition under nutrient stress conditions.,2023,10.1007/s13402-022-00754-w,https://pubmed.ncbi.nlm.nih.gov/36593375/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,40311472,BDE-209 toxicity: From spermiogenesis to sexual maturity in F1 male mice.,2025,10.1016/j.ecoenv.2025.118231,https://pubmed.ncbi.nlm.nih.gov/40311472/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,37526401,Immunization with a heat-killed prm1 deletion strain protects the host from Cryptococcus neoformans infection.,2023,10.1080/22221751.2023.2244087,https://pubmed.ncbi.nlm.nih.gov/37526401/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,40615456,Thymol alleviates silica dioxide nanoparticle-induced reproductive performance toxicity via antioxidant and anti-inflammatory mechanisms in male rats.,2025,10.1038/s41598-025-07769-x,https://pubmed.ncbi.nlm.nih.gov/40615456/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,40432750,I-PREFR: Inverse PCR-Based Restriction Enzyme FRee Unidirectional Strategy for Rapid Markerless Chromosomal Gene Deletion and Reconstitution in Bacteria Using Suicide Vectors.,2025,10.21769/bioprotoc.5314,https://pubmed.ncbi.nlm.nih.gov/40432750/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,40137503,Oxidative and Molecular-Structural Alterations of Spermatozoa in Swine and Ram Exposed to the Triazole Ipconazole.,2025,10.3390/toxics13030176,https://pubmed.ncbi.nlm.nih.gov/40137503/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,40185275,Development and validation of a deep learning model based on cascade mask regional convolutional neural network to noninvasively and accurately identify human round spermatids.,2026,10.1016/j.jare.2025.03.059,https://pubmed.ncbi.nlm.nih.gov/40185275/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,35116345,"The expression, function, and utilization of Protamine1: a literature review.",2021,10.21037/tcr-21-1582,https://pubmed.ncbi.nlm.nih.gov/35116345/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,37724144,"Gene Polymorphism, Microdeletion, and Gene Expression of PRM1, PRM2, AZFc in Infertile Males.",2023,10.52547/rbmb.12.1.173,https://pubmed.ncbi.nlm.nih.gov/37724144/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,35783678,The Activation of Protamine 1 Using Epigenome Editing Decreases the Proliferation of Tumorigenic Cells.,2022,10.3389/fgeed.2022.844904,https://pubmed.ncbi.nlm.nih.gov/35783678/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,40346865,Downregulation of spermatogenesis-associated transcripts in the spermatozoa of idiopathic infertile men.,2026,10.1111/andr.70060,https://pubmed.ncbi.nlm.nih.gov/40346865/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,39028130,Adverse Effects of Nicotine on Human Sperm Nuclear Proteins.,2025,10.5534/wjmh.240072,https://pubmed.ncbi.nlm.nih.gov/39028130/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,38668519,Decreased Ubiquitination and Acetylation of Histones 3 and 4 Are Associated with Obesity-Induced Disorders of Spermatogenesis in Mice.,2024,10.3390/toxics12040296,https://pubmed.ncbi.nlm.nih.gov/38668519/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,38135418,Decabromodiphenyl ether induces the chromosome association disorders of spermatocytes and deformation failures of spermatids in mice.,2024,10.1016/j.jes.2023.03.043,https://pubmed.ncbi.nlm.nih.gov/38135418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,38847481,Male infertility and perfluoroalkyl and poly-fluoroalkyl substances: evidence for alterations in phosphorylation of proteins and fertility-related functional attributes in bull spermatozoa†.,2024,10.1093/biolre/ioae089,https://pubmed.ncbi.nlm.nih.gov/38847481/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,31692026,Anticancer properties of green-synthesised zinc oxide nanoparticles using Hyssopus officinalis extract on prostate carcinoma cells and its effects on testicular damage and spermatogenesis in Balb/C mice.,2020,10.1111/and.13450,https://pubmed.ncbi.nlm.nih.gov/31692026/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,32991915,The ubiquitination and acetylation of histones are associated with male reproductive disorders induced by chronic exposure to arsenite.,2020,10.1016/j.taap.2020.115253,https://pubmed.ncbi.nlm.nih.gov/32991915/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,37946562,Evaluating the effect of conditioned medium from mesenchymal stem cells on differentiation of rat spermatogonial stem cells.,2023,10.5115/acb.22.246,https://pubmed.ncbi.nlm.nih.gov/37946562/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM1,ENSG00000175646,Unsafe,32146776,The effect of vitamin C on the gene expression profile of sperm protamines in the male partners of couples with recurrent pregnancy loss: A randomized clinical trial.,2020,10.5653/cerm.2019.03188,https://pubmed.ncbi.nlm.nih.gov/32146776/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,42812170,"Impaired antigen clearance of macrophages associates with heart failure and non-obstructive azoospermia: insights from transcriptomics, in silico knockout, and &lt;i&gt;in vitro&lt;/i&gt; validation.",2026,10.3389/fimmu.2026.1909437,https://pubmed.ncbi.nlm.nih.gov/42812170/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,41602862,Spatiotemporal dynamics of spermatogenesis: insights from high-resolution spatial transcriptomics and pseudotime trajectories in mouse testes.,2025,10.3389/frph.2025.1747902,https://pubmed.ncbi.nlm.nih.gov/41602862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,42266249,Combination drug therapy reduces iron accumulation and microglia-mediated pathologies in neonatal intraventricular hemorrhage: a biochemical and transcriptomic analysis.,2026,10.3389/fncel.2026.1812529,https://pubmed.ncbi.nlm.nih.gov/42266249/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,41393904,"Protamine1, 2 and Catsper1: sperm quality and fertility indicators in Stallions.",2025,10.1590/1984-3143-ar2025-0040,https://pubmed.ncbi.nlm.nih.gov/41393904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,39524225,Protamine 2 deficiency results in Septin 12 abnormalities.,2024,10.3389/fcell.2024.1447630,https://pubmed.ncbi.nlm.nih.gov/39524225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,41556312,Fertilization with Protamine-2 deficient sperm triggers abnormal pronucleus development and zygotic cleavage†.,2026,10.1093/biolre/ioag010,https://pubmed.ncbi.nlm.nih.gov/41556312/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,41354937,Dynamic architecture of mammalian paternal chromatin: histone-to-protamine exchange and post-fertilization reprogramming.,2025,10.1186/s13072-025-00651-0,https://pubmed.ncbi.nlm.nih.gov/41354937/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,42748838,Protamine gene expression is associated with sperm motility in rams: An integrative experimental and gene network analysis.,2026,10.1016/j.anireprosci.2026.108317,https://pubmed.ncbi.nlm.nih.gov/42748838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,41866036,PRAMEL12 orchestrates spermiogenesis to ensure male fertility in mice.,2026,10.1016/j.jbc.2026.111392,https://pubmed.ncbi.nlm.nih.gov/41866036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,41793517,Dysregulated methylation of the human BOLL promoter hinders germ cell development from spermatogonia to spermatids.,2026,10.1007/s11033-026-11633-0,https://pubmed.ncbi.nlm.nih.gov/41793517/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,42703367,"Modular 3D culture platform combining methylcellulose, testicular ECM, and Sertoli cells for &lt;i&gt;in vitro&lt;/i&gt; spermatogenesis.",2026,10.22038/ijbms.2026.93648.20214,https://pubmed.ncbi.nlm.nih.gov/42703367/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,39187928,"Sperm RNA quantity and PRM1, PRM2 , and TH2B transcript levels reflect sperm characteristics and early embryonic development.",2025,10.4103/aja202452,https://pubmed.ncbi.nlm.nih.gov/39187928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,41046257,Protamine expression in somatic cells condenses chromatin and disrupts transcription without altering DNA methylation.,2025,10.1186/s13072-025-00633-2,https://pubmed.ncbi.nlm.nih.gov/41046257/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,41397546,Research on the mechanism of Zuogui Wan in ameliorating oligoasthenozoospermia in rats via modulating cuproptosis-related pathways.,2026,10.1016/j.jep.2025.120990,https://pubmed.ncbi.nlm.nih.gov/41397546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,39688669,Coevolution and Adaptation of Transition Nuclear Proteins and Protamines in Naturally Ascrotal Mammals Support the Black Queen Hypothesis.,2024,10.1093/gbe/evae260,https://pubmed.ncbi.nlm.nih.gov/39688669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,40714522,Comparative study of sperm protamine gene expression and chromatin integrity in Nellore and Angus bulls.,2025,10.1016/j.repbio.2025.101051,https://pubmed.ncbi.nlm.nih.gov/40714522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,40959470,Association of sperm protamine1 and protamine2 transcript content with paternal age: A cross-sectional study.,2025,10.18502/ijrm.v23i6.19404,https://pubmed.ncbi.nlm.nih.gov/40959470/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,41136666,Environmental light deprivation disrupts Leydig cell maturation and male reproductive development in rats.,2025,10.1038/s41598-025-21236-7,https://pubmed.ncbi.nlm.nih.gov/41136666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,38187237,"FTHL17, PRM2, CABYR, CPXCR1, ADAM29, and CABS1 are highly expressed in colon cancer patients and are regulated in vitro by epigenetic alterations.",2024,10.1016/j.heliyon.2023.e23689,https://pubmed.ncbi.nlm.nih.gov/38187237/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,42038776,Association of Circular RNAs with Sperm Fertility Potential: Implications for Male Infertility Diagnosis.,2025,10.18502/jri.v26i4.21087,https://pubmed.ncbi.nlm.nih.gov/42038776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,42069234,Impact of 5-alpha reductase inhibitors on male reproductive health: A review of finasteride and dutasteride.,2026,10.1016/j.reprotox.2026.109257,https://pubmed.ncbi.nlm.nih.gov/42069234/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,37962947,Protective effect of selenium and vitamin C on the fertility of male rats given penconazole.,2024,10.5935/1518-0557.20230042,https://pubmed.ncbi.nlm.nih.gov/37962947/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,37724144,"Gene Polymorphism, Microdeletion, and Gene Expression of PRM1, PRM2, AZFc in Infertile Males.",2023,10.52547/rbmb.12.1.173,https://pubmed.ncbi.nlm.nih.gov/37724144/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,40676622,Circadian disruption impairs Leydig cell maturation and reproductive development in male rats.,2025,10.1186/s12958-025-01440-w,https://pubmed.ncbi.nlm.nih.gov/40676622/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,40346865,Downregulation of spermatogenesis-associated transcripts in the spermatozoa of idiopathic infertile men.,2026,10.1111/andr.70060,https://pubmed.ncbi.nlm.nih.gov/40346865/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,39028130,Adverse Effects of Nicotine on Human Sperm Nuclear Proteins.,2025,10.5534/wjmh.240072,https://pubmed.ncbi.nlm.nih.gov/39028130/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,35116345,"The expression, function, and utilization of Protamine1: a literature review.",2021,10.21037/tcr-21-1582,https://pubmed.ncbi.nlm.nih.gov/35116345/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,38135418,Decabromodiphenyl ether induces the chromosome association disorders of spermatocytes and deformation failures of spermatids in mice.,2024,10.1016/j.jes.2023.03.043,https://pubmed.ncbi.nlm.nih.gov/38135418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,30914484,Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo.,2019,10.1126/scisignal.aao7232,https://pubmed.ncbi.nlm.nih.gov/30914484/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,32146776,The effect of vitamin C on the gene expression profile of sperm protamines in the male partners of couples with recurrent pregnancy loss: A randomized clinical trial.,2020,10.5653/cerm.2019.03188,https://pubmed.ncbi.nlm.nih.gov/32146776/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,35211476,Anatomical Transcriptome Atlas of the Male Mouse Reproductive System During Aging.,2021,10.3389/fcell.2021.782824,https://pubmed.ncbi.nlm.nih.gov/35211476/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,32308937,Immunological reactions by T cell and regulation of crucial genes in treated celiac disease patients.,2020,,https://pubmed.ncbi.nlm.nih.gov/32308937/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,31492135,Exploration of genetic diversity of Plasmodium vivax circumsporozoite protein (Pvcsp) and Plasmodium vivax sexual stage antigen (Pvs25) among North Indian isolates.,2019,10.1186/s12936-019-2939-z,https://pubmed.ncbi.nlm.nih.gov/31492135/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM2,ENSG00000122304,Unsafe,33632220,Genetic characterization of Plasmodium vivax isolates from Pakistan using circumsporozoite protein (pvcsp) and merozoite surface protein-1 (pvmsp-1) genes as genetic markers.,2021,10.1186/s12936-021-03654-w,https://pubmed.ncbi.nlm.nih.gov/33632220/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,42518043,"Cross-species comparative transcriptomic analysis of spermatozoa reveals species-specific regulatory networks linked to fertilization-associated genes in cattle, sheep and goats.",2026,10.1007/s11427-024-3211-6,https://pubmed.ncbi.nlm.nih.gov/42518043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,40157598,Landscape of sex differences in obesity and type 2 diabetes in subcutaneous adipose tissue: a systematic review and meta-analysis of transcriptomics studies.,2025,10.1016/j.metabol.2025.156241,https://pubmed.ncbi.nlm.nih.gov/40157598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,38061432,Transcriptome and proteome analyses reveal the mechanisms involved in polystyrene nanoplastics disrupt spermatogenesis in mice.,2024,10.1016/j.envpol.2023.123086,https://pubmed.ncbi.nlm.nih.gov/38061432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,37093439,Improving effects of telmisartan on spermatogenic disorder induced by fractionated low-dose irradiation in mice.,2023,10.1007/s11255-023-03601-5,https://pubmed.ncbi.nlm.nih.gov/37093439/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,38142472,Protamine 2 and phospholipase C zeta 1 are possible biomarkers for the diagnosis of male subfertility in frozen-thawed stallion semen.,2024,10.1016/j.theriogenology.2023.12.012,https://pubmed.ncbi.nlm.nih.gov/38142472/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,37079096,Cryostress induces fragmentation and alters the abundance of sperm transcripts associated with fertilizing competence and reproductive processes in buffalo.,2023,10.1007/s00441-023-03764-8,https://pubmed.ncbi.nlm.nih.gov/37079096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,34840468,The potential of sperm bovine protamine as a protein marker of semen production and quality at the National Artificial Insemination Center of Indonesia.,2021,10.14202/vetworld.2021.2473-2481,https://pubmed.ncbi.nlm.nih.gov/34840468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,34573430,Whole-Genome Profiles of Malay Colorectal Cancer Patients with Intact MMR Proteins.,2021,10.3390/genes12091448,https://pubmed.ncbi.nlm.nih.gov/34573430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,28890397,Regulated expression of the TPβ isoform of the human T prostanoid receptor by the tumour suppressors FOXP1 and NKX3.1: Implications for the role of thromboxane in prostate cancer.,2017,10.1016/j.bbadis.2017.09.005,https://pubmed.ncbi.nlm.nih.gov/28890397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,34056671,Maize Endochitinase Expression in Response to Fall Armyworm Herbivory.,2021,10.1007/s10886-021-01284-9,https://pubmed.ncbi.nlm.nih.gov/34056671/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,31271729,Differential expression of the TPα and TPβ isoforms of the human T Prostanoid receptor during chronic inflammation of the prostate: Role for FOXP1 in the transcriptional regulation of TPβ during monocyte-macrophage differentiation.,2019,10.1016/j.yexmp.2019.104277,https://pubmed.ncbi.nlm.nih.gov/31271729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,29763643,Polysaccharide PRM3 from Rhynchosia minima root enhances immune function through TLR4-NF-κB pathway.,2018,10.1016/j.bbagen.2018.05.012,https://pubmed.ncbi.nlm.nih.gov/29763643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,33896876,Resveratrol supplementation into extender protects against cryodamage in dog post-thaw sperm.,2021,10.1292/jvms.21-0125,https://pubmed.ncbi.nlm.nih.gov/33896876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,32533872,"Effects of crocin on frozen-thawed sperm apoptosis, protamine expression and membrane lipid oxidation in Yanbian yellow cattle.",2020,10.1111/rda.13744,https://pubmed.ncbi.nlm.nih.gov/32533872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,35464478,"A Genome-Wide Association Study for Tolerance to Paratuberculosis Identifies Candidate Genes Involved in DNA Packaging, DNA Damage Repair, Innate Immunity, and Pathogen Persistence.",2022,10.3389/fimmu.2022.820965,https://pubmed.ncbi.nlm.nih.gov/35464478/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,31783679,Myoinositol Supplementation of Freezing Medium Improves the Quality-Related Parameters of Dog Sperm.,2019,10.3390/ani9121038,https://pubmed.ncbi.nlm.nih.gov/31783679/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,32504620,"Effects of kinetin supplementation on the post-thaw motility, viability, and structural integrity of dog sperm.",2020,10.1016/j.cryobiol.2020.05.015,https://pubmed.ncbi.nlm.nih.gov/32504620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,30481988,Iodixanol supplementation during sperm cryopreservation improves protamine level and reduces reactive oxygen species of canine sperm.,2019,10.4142/jvs.2019.20.1.79,https://pubmed.ncbi.nlm.nih.gov/30481988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,20944085,"Protamine 3 shows evidence of weak, positive selection in mouse species (genus Mus)--but it is not a protamine.",2011,10.1095/biolreprod.110.086454,https://pubmed.ncbi.nlm.nih.gov/20944085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,27512756,Transcriptional Regulation of the Human Thromboxane A2 Receptor Gene by Wilms’ Tumour (WT)1,2016,,https://pubmed.ncbi.nlm.nih.gov/27512756/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRM3,ENSG00000178257,Unsafe,26024441,"Defense Responses to Mycotoxin-Producing Fungi Fusarium proliferatum, F. subglutinans, and Aspergillus flavus in Kernels of Susceptible and Resistant Maize Genotypes.",2015,10.1094/mpmi-09-14-0269-r,https://pubmed.ncbi.nlm.nih.gov/26024441/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,42788414,Skeletal Muscle Transcriptomic Responses to Concurrent Training With Polyphenols in Ageing Adults: A Randomized Trial.,2026,10.1002/jcsm.70391,https://pubmed.ncbi.nlm.nih.gov/42788414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,40204637,The prion-family protein Doppel exerts a protective role during influenza virus infection.,2025,10.1093/jimmun/vkaf031,https://pubmed.ncbi.nlm.nih.gov/40204637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,41691491,Selective Targeting of Tip Endothelial Cells as a Therapeutic Strategy for Tumor Angiogenesis.,2026,10.1002/advs.202512975,https://pubmed.ncbi.nlm.nih.gov/41691491/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,39682402,First Report of Polymorphisms and Genetic Characteristics of Prion-like Protein Gene (PRND) in Cats.,2024,10.3390/ani14233438,https://pubmed.ncbi.nlm.nih.gov/39682402/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,38952802,The first report of single nucleotide polymorphisms in the open reading frame of the prion-like protein gene in rabbits.,2024,10.3389/fvets.2024.1388339,https://pubmed.ncbi.nlm.nih.gov/38952802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,40408976,Microfluidic captured patient-derived circulating endothelial cells identify novel targets of pulmonary arterial hypertension.,2025,10.1016/j.biomaterials.2025.123429,https://pubmed.ncbi.nlm.nih.gov/40408976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,40315480,Detection of polymorphisms in the prion-like protein Doppel (&lt;i&gt;PRND&lt;/i&gt;) gene in Jeju black cattle.,2025,10.1139/gen-2024-0145,https://pubmed.ncbi.nlm.nih.gov/40315480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,36215882,Phthalate plasticizer decreases the prion-like protein doppel essential for structural integrity and function of spermatozoa.,2022,10.1016/j.ecoenv.2022.114159,https://pubmed.ncbi.nlm.nih.gov/36215882/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,41034730,Ascophyllum nodosum based plant biostimulant shapes the bacterial community in the rhizosphere of corn.,2025,10.1186/s12870-025-07270-7,https://pubmed.ncbi.nlm.nih.gov/41034730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,32895288,The vascular endothelial cell-expressed prion protein doppel promotes angiogenesis and blood-brain barrier development.,2020,10.1242/dev.193094,https://pubmed.ncbi.nlm.nih.gov/32895288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,39338492,Identification of an Endogenous Strong Promoter in &lt;i&gt;Burkholderia&lt;/i&gt; sp. JP2-270.,2024,10.3390/microorganisms12091818,https://pubmed.ncbi.nlm.nih.gov/39338492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,34737762,Prognostic and Immune-Infiltrate Significance of miR-222-3p and Its Target Genes in Thyroid Cancer.,2021,10.3389/fgene.2021.710412,https://pubmed.ncbi.nlm.nih.gov/34737762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,37247874,Investing in a global pooled-funding mechanism for late-stage clinical trials of poverty-related and neglected diseases: an economic evaluation.,2023,10.1136/bmjgh-2023-011842,https://pubmed.ncbi.nlm.nih.gov/37247874/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,35436608,Single-cell RNA-seq analysis of testicular somatic cell development in pigs.,2022,10.1016/j.jgg.2022.03.014,https://pubmed.ncbi.nlm.nih.gov/35436608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,25364761,Role of the prion protein family in the gonads.,2014,10.3389/fcell.2014.00056,https://pubmed.ncbi.nlm.nih.gov/25364761/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,31238729,No polymorphisms in the coding region of the prion-like protein gene in Thoroughbred racehorses.,2019,10.1556/004.2019.019,https://pubmed.ncbi.nlm.nih.gov/31238729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,35776660,"ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver.",2023,10.1002/hep.32641,https://pubmed.ncbi.nlm.nih.gov/35776660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,33767596,Novel biomarkers for post-contrast acute kidney injury identified from long non-coding RNA expression profiles.,2021,10.7150/ijbs.45294,https://pubmed.ncbi.nlm.nih.gov/33767596/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,27047737,A specific role for PRND in goat foetal Leydig cells is suggested by prion family gene expression during gonad development in goats and mice.,2016,10.1002/2211-5463.12002,https://pubmed.ncbi.nlm.nih.gov/27047737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,30359416,Prion-like protein gene (PRND) polymorphisms associated with scrapie susceptibility in Korean native black goats.,2018,10.1371/journal.pone.0206209,https://pubmed.ncbi.nlm.nih.gov/30359416/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,42197960,Novel Dual Residual-Enhanced Deep Bidirectional LSTM Network for Soft Sensing of Rare Earth Component Content.,2026,10.3390/s26103152,https://pubmed.ncbi.nlm.nih.gov/42197960/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,39273455,Genomic Insights into Pseudomonas protegens E1BL2 from Giant Jala Maize: A Novel Bioresource for Sustainable Agriculture and Efficient Management of Fungal Phytopathogens.,2024,10.3390/ijms25179508,https://pubmed.ncbi.nlm.nih.gov/39273455/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,32392732,"Absence of Strong Genetic Linkage Disequilibrium between Single Nucleotide Polymorphisms (SNPs) in the Prion Protein Gene (PRNP) and the Prion-Like Protein Gene (PRND) in the Horse, a Prion-Resistant Species.",2020,10.3390/genes11050518,https://pubmed.ncbi.nlm.nih.gov/32392732/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,35634166,Analysis of the health product pipeline for poverty-related and neglected diseases using the Portfolio-to-Impact (P2I) modeling tool.,2020,10.12688/f1000research.24015.1,https://pubmed.ncbi.nlm.nih.gov/35634166/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,34800203,Identification of Hub Genes Associated with Abnormal Endothelial Function in Early Coronary Atherosclerosis.,2022,10.1007/s10528-021-10139-7,https://pubmed.ncbi.nlm.nih.gov/34800203/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,24263403,Effect of postradiotherapy neck dissection on nonregional disease sites.,2014,10.1001/jamaoto.2013.5754,https://pubmed.ncbi.nlm.nih.gov/24263403/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,27224046,Disparate Modes of Evolution Shaped Modern Prion (PRNP) and Prion-Related Doppel (PRND) Variation in Domestic Cattle.,2016,10.1371/journal.pone.0155924,https://pubmed.ncbi.nlm.nih.gov/27224046/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,32674273,"Transcriptional Profiling of Normal, Stenotic, and Regurgitant Human Aortic Valves.",2020,10.3390/genes11070789,https://pubmed.ncbi.nlm.nih.gov/32674273/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,24339999,Differential responses of neuronal and spermatogenic cells to the doppel cytotoxicity.,2013,10.1371/journal.pone.0082130,https://pubmed.ncbi.nlm.nih.gov/24339999/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,15007175,Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions.,2004,10.1073/pnas.0400131101,https://pubmed.ncbi.nlm.nih.gov/15007175/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,15161660,Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice.,2004,10.1016/s0002-9440(10)63784-4,https://pubmed.ncbi.nlm.nih.gov/15161660/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,26217959,Efficient PRNP deletion in bovine genome using gene-editing technologies in bovine cells.,2015,10.1080/19336896.2015.1071459,https://pubmed.ncbi.nlm.nih.gov/26217959/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,11306558,Normal neurogenesis and scrapie pathogenesis in neural grafts lacking the prion protein homologue Doppel.,2001,10.1093/embo-reports/kve088,https://pubmed.ncbi.nlm.nih.gov/11306558/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,19798432,Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones.,2009,10.1371/journal.ppat.1000608,https://pubmed.ncbi.nlm.nih.gov/19798432/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRND,ENSG00000171864,Unsafe,12200435,"The human ""prion-like"" protein Doppel is expressed in both Sertoli cells and spermatozoa.",2002,10.1074/jbc.m206357200,https://pubmed.ncbi.nlm.nih.gov/12200435/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROCA1,ENSG00000167525,Unsafe,38867036,Unraveling the Impact of the PROCA1 Mutation in Male Infertility: Incorporating Whole Exome Sequencing in Teratozoospermia Patients and Analyzing Proca1 Knockout Mice.,2025,10.1007/s43032-024-01624-6,https://pubmed.ncbi.nlm.nih.gov/38867036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROCA1,ENSG00000167525,Unsafe,38923758,Obesity enhances the response to neoadjuvant anti-PD1 therapy in oral tongue squamous cell carcinoma.,2024,10.1002/cam4.7346,https://pubmed.ncbi.nlm.nih.gov/38923758/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROCA1,ENSG00000167525,Unsafe,36627670,Downregulation of Linc00173 increases BCL2 mRNA stability via the miR-1275/PROCA1/ZFP36L2 axis and induces acquired cisplatin resistance of lung adenocarcinoma.,2023,10.1186/s13046-022-02560-6,https://pubmed.ncbi.nlm.nih.gov/36627670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROCA1,ENSG00000167525,Unsafe,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROCA1,ENSG00000167525,Unsafe,34740325,A lipid metabolism-related genes prognosis biomarker associated with the tumor immune microenvironment in colorectal carcinoma.,2021,10.1186/s12885-021-08902-5,https://pubmed.ncbi.nlm.nih.gov/34740325/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROCA1,ENSG00000167525,Unsafe,27071673,ProCA1.GRPR: a new imaging agent in cancer detection.,2016,10.2217/bmm-2016-0040,https://pubmed.ncbi.nlm.nih.gov/27071673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROCA1,ENSG00000167525,Unsafe,26577829,GRPR-targeted Protein Contrast Agents for Molecular Imaging of Receptor Expression in Cancers by MRI.,2015,10.1038/srep16214,https://pubmed.ncbi.nlm.nih.gov/26577829/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROCA1,ENSG00000167525,Unsafe,20574851,Protein-based MRI contrast agents for molecular imaging of prostate cancer.,2011,10.1007/s11307-010-0342-9,https://pubmed.ncbi.nlm.nih.gov/20574851/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROCA1,ENSG00000167525,Unsafe,22178673,PEGylation of protein-based MRI contrast agents improves relaxivities and biocompatibilities.,2012,10.1016/j.jinorgbio.2011.11.004,https://pubmed.ncbi.nlm.nih.gov/22178673/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROCA1,ENSG00000167525,Unsafe,15159402,Identification of interaction partners and substrates of the cyclin A1-CDK2 complex.,2004,10.1074/jbc.m401708200,https://pubmed.ncbi.nlm.nih.gov/15159402/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROCA1,ENSG00000167525,Unsafe,38180819,Protein MRI Contrast Agents as an Effective Approach for Precision Molecular Imaging.,2024,10.1097/rli.0000000000001057,https://pubmed.ncbi.nlm.nih.gov/38180819/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,42573649,Integrative transcriptomic analysis and experimental validation identify GPR97 and PROK2 as novel genes upregulated in acute myocardial infarction.,2026,10.1007/s10142-026-02006-8,https://pubmed.ncbi.nlm.nih.gov/42573649/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,41998641,PROK2 defines a pathogenic neutrophil subset and serves as a clinical indicator of neutrophilic inflammation in COPD.,2026,10.1186/s12931-026-03679-2,https://pubmed.ncbi.nlm.nih.gov/41998641/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,42449499,The Pathogenicity Analysis of a Hypogonadotropic Hypogonadism Patient With the Novel Variant in the Deep Intronic Region of the PROK2 Gene.,2026,10.1002/mgg3.70267,https://pubmed.ncbi.nlm.nih.gov/42449499/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,40766783,Spatiotemporal regulation by downstream genes of &lt;i&gt;Prok2&lt;/i&gt; in the olfactory system: from development to function.,2025,10.3389/fcell.2025.1550845,https://pubmed.ncbi.nlm.nih.gov/40766783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,42730994,Identifying JAK2 and ANXA5 as Key Genes Linking Obstructive Sleep Apnea and Oxidative Stress via Machine Learning and Multilayer Transcriptomic Integration With Functional Validation.,2026,10.1096/fj.202602273r,https://pubmed.ncbi.nlm.nih.gov/42730994/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,41530832,The Prokineticin system is downregulated in idiopathic rapid eye movement sleep behavior disorder: evidence from olfactory neurons.,2026,10.1093/sleep/zsag006,https://pubmed.ncbi.nlm.nih.gov/41530832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,40841926,Synergistic effects of Bifidobacterium longum subsp. infantis B8762 and milk-derived osteopontin on male reproductive health in mice.,2025,10.1002/jsfa.70121,https://pubmed.ncbi.nlm.nih.gov/40841926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,40091048,Single-cell transcriptomic analysis reveals dynamic changes in the liver microenvironment during colorectal cancer metastatic progression.,2025,10.1186/s12967-025-06351-3,https://pubmed.ncbi.nlm.nih.gov/40091048/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,39946968,Possible therapeutic effects of PROK2 in testicular ischemia/reperfusion injury: A preclinical study in Wistar albino rats.,2025,10.1016/j.tice.2025.102778,https://pubmed.ncbi.nlm.nih.gov/39946968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,38740671,Intracerebroventricular PROK2 infusion could increase the secretion of male reproductive hormones by stimulating the HPG axis.,2024,10.1007/s11033-024-09604-4,https://pubmed.ncbi.nlm.nih.gov/38740671/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,39978670,Prok2/PKR signaling regulates ferroptosis after spinal cord injury.,2025,10.1016/j.neuroscience.2025.02.030,https://pubmed.ncbi.nlm.nih.gov/39978670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,40498399,Expanding the phenotypic spectrum of PROK2/PROKR2: a recall-by-genotype study.,2025,10.1007/s00439-025-02754-w,https://pubmed.ncbi.nlm.nih.gov/40498399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,41760108,"Shared Blood Transcriptomic and Pathway Signatures in Major Depression, Generalized Anxiety, and Obsessive-Compulsive Disorder: A Systems-Level Study.",2026,10.1002/ajmg.b.70010,https://pubmed.ncbi.nlm.nih.gov/41760108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,36289651,Prokineticin 2/PROK2 and Male Infertility.,2022,10.3390/biomedicines10102389,https://pubmed.ncbi.nlm.nih.gov/36289651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,40745616,Single-cell sequencing-based study of ferroptosis mechanisms in heat stroke: identification of key biomarkers and dynamic analysis of the immune microenvironment.,2025,10.1186/s12920-025-02188-3,https://pubmed.ncbi.nlm.nih.gov/40745616/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,40855347,Potential novel diagnostic biomarkers of atrial fibrillation: four ferroptosis-related genes linking immune infiltration.,2025,10.1186/s40001-025-03092-3,https://pubmed.ncbi.nlm.nih.gov/40855347/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,40460050,Analysis of the inflammatory gene expression characteristics and immune microenvironment regulatory mechanisms in the testicular tissue of patients with non-obstructive azoospermia.,2025,10.1371/journal.pone.0324948,https://pubmed.ncbi.nlm.nih.gov/40460050/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,39915377,The Effect of Endometrial Polyp and Myoma Uteri on Fertility-Related Genes in the Endometrium.,2025,10.1007/s43032-025-01802-0,https://pubmed.ncbi.nlm.nih.gov/39915377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,41038741,Whole transcriptome analysis of peripheral blood mononuclear cells from de novo and drug-naive Parkinson's disease patients.,2025,10.1016/j.neurot.2025.e00762,https://pubmed.ncbi.nlm.nih.gov/41038741/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,37813987,In vivo recording of the circadian calcium rhythm in Prokineticin 2 neurons of the suprachiasmatic nucleus.,2023,10.1038/s41598-023-44282-5,https://pubmed.ncbi.nlm.nih.gov/37813987/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,39684426,Machine Learning Integration with Single-Cell Transcriptome Sequencing Datasets Reveals the Impact of Tumor-Associated Neutrophils on the Immune Microenvironment and Immunotherapy Outcomes in Gastric Cancer.,2024,10.3390/ijms252312715,https://pubmed.ncbi.nlm.nih.gov/39684426/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,41917171,Neutrophil-related gene expression profile is associated with future paediatric bronchiectasis exacerbations.,2026,10.1007/s00109-026-02662-0,https://pubmed.ncbi.nlm.nih.gov/41917171/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,41667698,HLA-DPA1 as a diagnostic biomarker differentiating early- and late-onset preeclampsia.,2026,10.1038/s41598-026-39050-0,https://pubmed.ncbi.nlm.nih.gov/41667698/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,37484015,Identification of PROK2 gene polymorphisms as predictors of methamphetamine use disorder risk and indicators of craving scale in the Chinese Han population.,2023,10.3389/fphar.2023.1217382,https://pubmed.ncbi.nlm.nih.gov/37484015/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,41680500,Protein networks are influenced by maternal BMI and differentiate preterm birth types.,2026,10.1038/s43856-026-01376-1,https://pubmed.ncbi.nlm.nih.gov/41680500/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,36203970,Alzheimer's disease-associated inflammatory pathways might contribute to osteoporosis through the interaction between PROK2 and CSF3.,2022,10.3389/fneur.2022.990779,https://pubmed.ncbi.nlm.nih.gov/36203970/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,33732160,The Role of Prokineticin 2 in Oxidative Stress and in Neuropathological Processes.,2021,10.3389/fphar.2021.640441,https://pubmed.ncbi.nlm.nih.gov/33732160/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,34244497,Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury.,2021,10.1038/s41467-021-24469-y,https://pubmed.ncbi.nlm.nih.gov/34244497/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,32817421,Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer.,2020,10.1073/pnas.2008112117,https://pubmed.ncbi.nlm.nih.gov/32817421/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PROK2,ENSG00000163421,Unsafe,31766244,Involvement of the Chemokine Prokineticin-2 (PROK2) in Alzheimer's Disease: From Animal Models to the Human Pathology.,2019,10.3390/cells8111430,https://pubmed.ncbi.nlm.nih.gov/31766244/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,41826300,Hypusination of the translation factor eIF5A regulates mitochondrial tRNA processing to promote prostate cancer aggressiveness.,2026,10.1038/s41467-026-70566-1,https://pubmed.ncbi.nlm.nih.gov/41826300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,41772230,Expanding the genotypic spectrum of combined oxidative phosphorylation deficiency 54.,2026,10.1007/s10048-026-00892-5,https://pubmed.ncbi.nlm.nih.gov/41772230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,39503847,Cytosolic &lt;i&gt;N6AMT1-&lt;/i&gt;dependent translation supports mitochondrial RNA processing.,2024,10.1073/pnas.2414187121,https://pubmed.ncbi.nlm.nih.gov/39503847/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,41101502,RNase P generated tRF&lt;sup&gt;Ser-GCT&lt;/sup&gt; promotes fat storage in adipocytes via Adrb2 signaling.,2025,10.1016/j.jbc.2025.110820,https://pubmed.ncbi.nlm.nih.gov/41101502/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,39878214,WBSCR16 is essential for mitochondrial 16S rRNA processing in mammals.,2025,10.1093/nar/gkae1325,https://pubmed.ncbi.nlm.nih.gov/39878214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,38262497,Comprehensive functional interrogation of susceptibility loci in GWASs identified KIAA0391 as a novel oncogenic driver via regulating pyroptosis in NSCLC.,2024,10.1016/j.canlet.2024.216646,https://pubmed.ncbi.nlm.nih.gov/38262497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,37558808,Novel homozygous variants in PRORP expand the genotypic spectrum of combined oxidative phosphorylation deficiency 54.,2023,10.1038/s41431-023-01437-2,https://pubmed.ncbi.nlm.nih.gov/37558808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,38336295,"Discovery, structure, mechanisms, and evolution of protein-only RNase P enzymes.",2024,10.1016/j.jbc.2024.105731,https://pubmed.ncbi.nlm.nih.gov/38336295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,37779095,Cleavage kinetics of human mitochondrial RNase P and contribution of its non-nuclease subunits.,2023,10.1093/nar/gkad713,https://pubmed.ncbi.nlm.nih.gov/37779095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,34715011,Bi-allelic variants in the mitochondrial RNase P subunit PRORP cause mitochondrial tRNA processing defects and pleiotropic multisystem presentations.,2021,10.1016/j.ajhg.2021.10.002,https://pubmed.ncbi.nlm.nih.gov/34715011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,38453211,"The protein-only RNase Ps, endonucleases that cleave pre-tRNA: Biological relevance, molecular architectures, substrate recognition and specificity, and protein interactomes.",2024,10.1002/wrna.1836,https://pubmed.ncbi.nlm.nih.gov/38453211/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,39938738,Advances in Human Pre-tRNA Maturation: TRMT10C and ELAC2 in Focus.,2025,10.1016/j.jmb.2025.168989,https://pubmed.ncbi.nlm.nih.gov/39938738/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,34559558,A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance.,2021,10.1126/sciadv.abi7514,https://pubmed.ncbi.nlm.nih.gov/34559558/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,41261864,Substrate and enzyme determinants for recognition by human mitochondrial RNase P.,2025,10.1093/nar/gkaf1145,https://pubmed.ncbi.nlm.nih.gov/41261864/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,36370850,Gambogic acid and juglone inhibit RNase P through distinct mechanisms.,2022,10.1016/j.jbc.2022.102683,https://pubmed.ncbi.nlm.nih.gov/36370850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,32221480,Analysis of mitochondrial m1A/G RNA modification reveals links to nuclear genetic variants and associated disease processes.,2020,10.1038/s42003-020-0879-3,https://pubmed.ncbi.nlm.nih.gov/32221480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,38824131,Structural basis for human mitochondrial tRNA maturation.,2024,10.1038/s41467-024-49132-0,https://pubmed.ncbi.nlm.nih.gov/38824131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,35663400,"Reduction of &lt;i&gt;Drosophila&lt;/i&gt; Mitochondrial RNase P in Skeletal and Heart Muscle Causes Muscle Degeneration, Cardiomyopathy, and Heart Arrhythmia.",2022,10.3389/fcell.2022.788516,https://pubmed.ncbi.nlm.nih.gov/35663400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,35869520,Identification of human mitochondrial RNA cleavage sites and candidate RNA processing factors.,2022,10.1186/s12915-022-01373-5,https://pubmed.ncbi.nlm.nih.gov/35869520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,31455609,"Interplay between substrate recognition, 5' end tRNA processing and methylation activity of human mitochondrial RNase P.",2019,10.1261/rna.069310.118,https://pubmed.ncbi.nlm.nih.gov/31455609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,25314818,Efficacy of two canine distemper vaccines in wild Nearctic river otters (Lontra canadensis).,2014,10.1638/2013-0145r1.1,https://pubmed.ncbi.nlm.nih.gov/25314818/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,29422286,"Visit-to-visit lipid variability: Clinical significance, effects of lipid-lowering treatment, and (pharmaco) genetics.",2018,10.1016/j.jacl.2018.01.001,https://pubmed.ncbi.nlm.nih.gov/29422286/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,26031901,Genome-wide association study of leukotriene modifier response in asthma.,2016,10.1038/tpj.2015.34,https://pubmed.ncbi.nlm.nih.gov/26031901/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,30414965,Biochemical Studies Provide Insights into the Necessity for Multiple Arabidopsis thaliana Protein-Only RNase P Isoenzymes.,2019,10.1016/j.jmb.2018.11.004,https://pubmed.ncbi.nlm.nih.gov/30414965/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,32272761,Old and New Concepts in Ubiquitin and NEDD8 Recognition.,2020,10.3390/biom10040566,https://pubmed.ncbi.nlm.nih.gov/32272761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,29584801,Immunochip Meta-Analysis of Inflammatory Bowel Disease Identifies Three Novel Loci and Four Novel Associations in Previously Reported Loci.,2018,10.1093/ecco-jcc/jjy002,https://pubmed.ncbi.nlm.nih.gov/29584801/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRORP,ENSG00000100890,Unsafe,27166372,"Use of chemical modification and mass spectrometry to identify substrate-contacting sites in proteinaceous RNase P, a tRNA processing enzyme.",2016,10.1093/nar/gkw391,https://pubmed.ncbi.nlm.nih.gov/27166372/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,42910810,"Quantitative Fundus Autofluorescence in Geographic Atrophy Secondary to AMD: Comparison With Stargardt Disease, PRPH2-Associated Retinal Dystrophies, and Healthy Controls.",2026,10.1167/iovs.67.12.50,https://pubmed.ncbi.nlm.nih.gov/42910810/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,42897157,"Age- and sex-dependent retinal degeneration in peripherin-2 mutant mice, a model of central areolar choroidal dystrophy.",2026,10.1038/s41420-026-03263-z,https://pubmed.ncbi.nlm.nih.gov/42897157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,42145051,Visualization of peripheral nerves in developing and regenerating limbs using a novel peripherin reporter line of Xenopus laevis.,2026,10.1242/bio.062651,https://pubmed.ncbi.nlm.nih.gov/42145051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,42259879,"Evaluation of serum neurofilament light chain, GFAP, and peripherin as biomarkers in hereditary transthyretin amyloidosis.",2026,10.1038/s41598-026-56777-y,https://pubmed.ncbi.nlm.nih.gov/42259879/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,41210588,Prime editing for the investigation of aberrant splicing defect associated with a pathogenic &lt;i&gt;PRPH2&lt;/i&gt; variant.,2025,10.1016/j.omtn.2025.102740,https://pubmed.ncbi.nlm.nih.gov/41210588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,41979252,ABCA4 Versus PRPH2-Associated Retinopathy: Clinical and Electrophysiological Findings.,2026,10.1167/iovs.67.4.29,https://pubmed.ncbi.nlm.nih.gov/41979252/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,42570777,Single-cell spatial transcriptomics reveals rewiring of RPE and Müller glia signaling toward photoreceptors following outer segment disruption in Prph2&lt;sup&gt;C213Y&lt;/sup&gt; mice.,2026,10.1016/j.nbd.2026.107572,https://pubmed.ncbi.nlm.nih.gov/42570777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,41165193,"The segregation of Calb1, Calb2, and Prph neurons reveals distinct and mixed neuronal populations and projections to hair cells in the inner ear and central nuclei.",2026,10.1002/dvdy.70093,https://pubmed.ncbi.nlm.nih.gov/41165193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,40476320,Peripherin: A Novel Early Diagnostic and Prognostic Plasmatic Biomarker in Amyotrophic Lateral Sclerosis.,2025,10.1111/ene.70241,https://pubmed.ncbi.nlm.nih.gov/40476320/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,41566375,Comprehensive insights into sepsis-induced cardiac dysfunction through proteomics and metabolomics.,2026,10.1186/s13104-026-07657-1,https://pubmed.ncbi.nlm.nih.gov/41566375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,40133378,Developmental differentiation of mouse inner ear neuron subpopulations resolved with a peripherin-promoter reporter within the Grm8 locus.,2025,10.1038/s41598-025-94011-3,https://pubmed.ncbi.nlm.nih.gov/40133378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,42748994,Bioactive keratin-pectin methacrylate multifilament nerve conduits for functional regeneration across segmental nerve defects.,2026,10.1016/j.ijbiomac.2026.154521,https://pubmed.ncbi.nlm.nih.gov/42748994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,42309337,Optimizing NGN2 Dosage Enhances the Neuronal Enrichment of iPSC-Derived Neuronal Cultures.,2026,10.1016/j.mcpro.2026.101604,https://pubmed.ncbi.nlm.nih.gov/42309337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,40725586,Bilateral Sector Macular Dystrophy Associated with &lt;i&gt;PRPH2&lt;/i&gt; Variant c.623G&gt;A (p.Gly208Asp).,2025,10.3390/jcm14144893,https://pubmed.ncbi.nlm.nih.gov/40725586/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,41992230,Elevating Jak-STAT signaling via SOCS3 deletion sustains photoreceptor viability and visual function in mouse models of retinitis pigmentosa.,2026,10.1186/s12964-026-02878-0,https://pubmed.ncbi.nlm.nih.gov/41992230/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,40722607,Expanding Genetic and Clinical Spectra of Inherited Retinal Dystrophies: Identification of Three Novel &lt;i&gt;PRPH2&lt;/i&gt; Variants.,2025,10.3390/biomedicines13071531,https://pubmed.ncbi.nlm.nih.gov/40722607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,39382871,Current and Future Directions in Developing Effective Treatments for PRPH2-Associated Retinal Diseases: A Workshop Report.,2024,10.1167/tvst.13.10.16,https://pubmed.ncbi.nlm.nih.gov/39382871/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,39231530,A new mouse model for PRPH2 pattern dystrophy exhibits functional compensation prior and subsequent to retinal degeneration.,2024,10.1093/hmg/ddae128,https://pubmed.ncbi.nlm.nih.gov/39231530/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,41009962,"Genotype-Phenotype Correlations in &lt;i&gt;PRPH2&lt;/i&gt; Retinopathies: A Comprehensive Analysis of 36 Patients from the Oxford Eye Hospital, UK.",2025,10.3390/genes16091016,https://pubmed.ncbi.nlm.nih.gov/41009962/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,42385173,Retinal dystrophies simulating geographic atrophy: A diagnostic challenge.,2026,10.1111/aos.70184,https://pubmed.ncbi.nlm.nih.gov/42385173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,42316356,Investigating PRPH2-associated retinal degeneration patient-reported outcomes in vision-related quality of life.,2026,10.1186/s12886-026-05011-4,https://pubmed.ncbi.nlm.nih.gov/42316356/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,39610584,Intrafamilial Phenotypic Variability in PRPH2-Related Retinopathy.,2024,10.7759/cureus.72580,https://pubmed.ncbi.nlm.nih.gov/39610584/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,39944181,Clearing the AIR: A &lt;i&gt;PRPH2&lt;/i&gt; mutation identified in the evaluation of presumed autoimmune retinopathy.,2025,10.1016/j.ajoc.2025.102252,https://pubmed.ncbi.nlm.nih.gov/39944181/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,38834544,Downregulation of rhodopsin is an effective therapeutic strategy in ameliorating peripherin-2-associated inherited retinal disorders.,2024,10.1038/s41467-024-48846-5,https://pubmed.ncbi.nlm.nih.gov/38834544/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,39693084,Clinical and Imaging Characteristics of PRPH2 Retinopathies in a Longitudinal Cohort and Diagnostic Implications.,2024,10.1167/iovs.65.14.31,https://pubmed.ncbi.nlm.nih.gov/39693084/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,38474159,PRPH2-Related Retinal Dystrophies: Mutational Spectrum in 103 Families from a Spanish Cohort.,2024,10.3390/ijms25052913,https://pubmed.ncbi.nlm.nih.gov/38474159/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,40828619,Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy.,2025,10.1172/jci184075,https://pubmed.ncbi.nlm.nih.gov/40828619/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,42358619,Disease and Participant-Related Correlates of Genetic Testing Completion for Hereditary Eye Disorders in a Cohort of over 1400 Patients.,2026,10.1016/j.xops.2026.101218,https://pubmed.ncbi.nlm.nih.gov/42358619/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,41514076,Inherited retinal disorders in Scotland: A 5 year assessment.,2026,10.1038/s41433-025-04216-z,https://pubmed.ncbi.nlm.nih.gov/41514076/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,37466729,Comparative study of PRPH2 D2 loop mutants reveals divergent disease mechanism in rods and cones.,2023,10.1007/s00018-023-04851-3,https://pubmed.ncbi.nlm.nih.gov/37466729/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,39556087,Optimization of HITI-Mediated Gene Insertion for Rhodopsin and Peripherin-2 in Mouse Rod Photoreceptors: Targeting Dominant Retinitis Pigmentosa.,2024,10.1167/iovs.65.13.38,https://pubmed.ncbi.nlm.nih.gov/39556087/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRPH2,ENSG00000112619,Unsafe,36351012,Cryo-EM structures of peripherin-2 and ROM1 suggest multiple roles in photoreceptor membrane morphogenesis.,2022,10.1126/sciadv.add3677,https://pubmed.ncbi.nlm.nih.gov/36351012/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,42500608,PRR11 expression in early ER+/HER2-low breast cancer: Association with estrogen receptor positivity and exploratory analysis of prognostic significance.,2026,10.3892/ol.2026.15766,https://pubmed.ncbi.nlm.nih.gov/42500608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,42445382,Divergent roles of PRR11 and HEPACAM in pleural mesothelioma: PRR11 as a prognostic biomarker and HEPACAM as a stage-associated gene with paradoxical expression.,2026,10.21037/tcr-2026-0657,https://pubmed.ncbi.nlm.nih.gov/42445382/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,41602397,Prognostic value and experimental validation of atherosclerosis-derived pathogenic genes in colorectal cancer.,2025,10.3389/fonc.2025.1728087,https://pubmed.ncbi.nlm.nih.gov/41602397/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,42838434,"Lipid droplet-associated proteins integrate lipid metabolism, cell cycle, and cytoskeletal remodeling in colon cancer.",2026,10.1016/j.jlr.2026.101165,https://pubmed.ncbi.nlm.nih.gov/42838434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,41575699,PRR11 as a newly identified oncogenic driver in retinoblastoma.,2026,10.1007/s11427-025-3094-0,https://pubmed.ncbi.nlm.nih.gov/41575699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,41366310,Plasma proteomic signatures in HIV-infected individuals post-SARS-CoV-2 infection.,2025,10.1186/s12879-025-12307-1,https://pubmed.ncbi.nlm.nih.gov/41366310/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,39583185,Screening for proline‑rich protein 11 gene expression in cervical cancer: Use as a novel diagnostic biomarker and poor prognostic factor.,2025,10.3892/mi.2024.202,https://pubmed.ncbi.nlm.nih.gov/39583185/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,40062654,PRR11 Promotes Bladder Cancer Growth and Metastasis by Facilitating G1/S Progression and Epithelial-Mesenchymal Transition.,2025,10.1002/cam4.70749,https://pubmed.ncbi.nlm.nih.gov/40062654/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,42242683,Identification and characterization of lncRNA-stemness-immune regulatory patterns.,2026,10.1093/bib/bbag287,https://pubmed.ncbi.nlm.nih.gov/42242683/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,41309933,Overexpressed PRR11-SKA2-miR301a/454 bidirectional transcription unit essentially and coordinately promotes PI3K-AKT pathway activation and lung cancer progression.,2026,10.1038/s41388-025-03607-6,https://pubmed.ncbi.nlm.nih.gov/41309933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,40083925,FBXW7/GSK3β-mediated proline-rich 11 degradation promotes oxidative DNA damage and inhibits tumor progression in renal cell carcinoma.,2025,10.7150/thno.106018,https://pubmed.ncbi.nlm.nih.gov/40083925/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,38427643,Prognostic value of PRR11 and immune cell infiltration in Ewing sarcoma.,2024,10.1371/journal.pone.0299720,https://pubmed.ncbi.nlm.nih.gov/38427643/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,38760964,Common immunological and prognostic features of lung and bladder cancer via smoking-related genes: PRR11 gene as potential immunotherapeutic target.,2024,10.1111/jcmm.18384,https://pubmed.ncbi.nlm.nih.gov/38760964/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,38838551,A targetable PRR11-DHODH axis drives ferroptosis- and temozolomide-resistance in glioblastoma.,2024,10.1016/j.redox.2024.103220,https://pubmed.ncbi.nlm.nih.gov/38838551/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,37233443,In silico analysis reveals PRR11 as a prognostic and oncogenic marker in lung adenocarcinoma.,2023,10.1097/md.0000000000033755,https://pubmed.ncbi.nlm.nih.gov/37233443/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,38843413,Impact of PRR11 Expression on Prognosis in Pancreatic Cancer Patients with Diabetes.,2024,,https://pubmed.ncbi.nlm.nih.gov/38843413/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,36551227,PRR11 in Malignancies: Biological Activities and Targeted Therapies.,2022,10.3390/biom12121800,https://pubmed.ncbi.nlm.nih.gov/36551227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,36739300,PRR11 is a prognostic biomarker and correlates with immune infiltrates in bladder urothelial carcinoma.,2023,10.1038/s41598-023-29316-2,https://pubmed.ncbi.nlm.nih.gov/36739300/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,37641376,ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and motility in early pregnancy.,2023,10.1111/aji.13758,https://pubmed.ncbi.nlm.nih.gov/37641376/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,36060253,PRR11 promotes cell proliferation by regulating PTTG1 through interacting with E2F1 transcription factor in pan-cancer.,2022,10.3389/fmolb.2022.877320,https://pubmed.ncbi.nlm.nih.gov/36060253/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,40629317,The related SNPs and genes to body size using GWAS- latent variable modeling in dromedaries.,2025,10.1186/s12864-025-11766-9,https://pubmed.ncbi.nlm.nih.gov/40629317/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,33057583,"Ultrasonic irradiation and SonoVue microbubbles-mediated RNA interference targeting PRR11 inhibits breast cancer cells proliferation and metastasis, but promotes apoptosis.",2020,10.1042/bsr20201854,https://pubmed.ncbi.nlm.nih.gov/33057583/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,38281298,Comprehensive analysis of co-expressed genes with TDP-43: prognostic and therapeutic potential in lung adenocarcinoma.,2024,10.1007/s00432-023-05554-9,https://pubmed.ncbi.nlm.nih.gov/38281298/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,36843949,"Identification and validation of a novel cuproptosis-related genes signature associated with prognosis, clinical implications and immunotherapy of hepatocellular carcinoma.",2023,10.3389/fphar.2023.1088993,https://pubmed.ncbi.nlm.nih.gov/36843949/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,33477943,HEDGEHOG/GLI Modulates the PRR11-SKA2 Bidirectional Transcription Unit in Lung Squamous Cell Carcinomas.,2021,10.3390/genes12010120,https://pubmed.ncbi.nlm.nih.gov/33477943/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,36785674,Identification of a Five Immune Term Signature for Prognosis and Therapy Options (Immunotherapy versus Targeted Therapy) for Patients with Hepatocellular Carcinoma.,2023,10.1155/2023/8958962,https://pubmed.ncbi.nlm.nih.gov/36785674/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,33127913,Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer.,2020,10.1038/s41467-020-19291-x,https://pubmed.ncbi.nlm.nih.gov/33127913/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,34379360,PRR11 unveiled as a top candidate biomarker within the RBM3-regulated transcriptome in pancreatic cancer.,2022,10.1002/cjp2.238,https://pubmed.ncbi.nlm.nih.gov/34379360/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,37542549,Comprehensive analysis of CPSF4-related alternative splice genes in hepatocellular carcinoma.,2023,10.1007/s00432-023-05178-z,https://pubmed.ncbi.nlm.nih.gov/37542549/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,32588681,A chalcone inhibits the growth and metastasis of KYSE-4 esophageal cancer cells.,2020,10.1177/0300060520928831,https://pubmed.ncbi.nlm.nih.gov/32588681/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR11,ENSG00000068489,Unsafe,23246489,PRR11 is a novel gene implicated in cell cycle progression and lung cancer.,2013,10.1016/j.biocel.2012.12.002,https://pubmed.ncbi.nlm.nih.gov/23246489/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR19,ENSG00000188368,Unsafe,42339205,Identification of the homozygous truncating mutation in &lt;i&gt;CNTD1&lt;/i&gt; as a novel genetic cause of diminished ovarian reserve.,2026,10.1016/j.gendis.2025.101900,https://pubmed.ncbi.nlm.nih.gov/42339205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR19,ENSG00000188368,Unsafe,42793237,Survival-Associated Molecular and Epigenetic Alterations in Endocervical Adenocarcinoma: An Exploratory TCGA Multi-Omics Cohort Study.,2026,10.3390/cimb48090881,https://pubmed.ncbi.nlm.nih.gov/42793237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR19,ENSG00000188368,Unsafe,32555348,Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse.,2020,10.1038/s41467-020-16885-3,https://pubmed.ncbi.nlm.nih.gov/32555348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR22,ENSG00000212123,Unsafe,41029016,PRR22: A Novel Prognostic Indicator and Therapeutic Target for Prostate Cancer.,2026,10.2174/0118715206415552250910202624,https://pubmed.ncbi.nlm.nih.gov/41029016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR22,ENSG00000212123,Unsafe,25481096,Identification of a novel isoform of the leukemia-associated MLLT1 (ENL/LTG19) protein.,2015,10.1016/j.gep.2014.11.003,https://pubmed.ncbi.nlm.nih.gov/25481096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR27,ENSG00000187533,Unsafe,40686951,Machine Learning-Based Analysis of Salivary Proteomic Signatures in Catathrenia.,2025,10.1021/acsomega.5c00418,https://pubmed.ncbi.nlm.nih.gov/40686951/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR27,ENSG00000187533,Unsafe,37591874,Cell-specific and shared regulatory elements control a multigene locus active in mammary and salivary glands.,2023,10.1038/s41467-023-40712-0,https://pubmed.ncbi.nlm.nih.gov/37591874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR27,ENSG00000187533,Unsafe,27508494,Susceptibility to Childhood Pneumonia: A Genome-Wide Analysis.,2017,10.1165/rcmb.2016-0101oc,https://pubmed.ncbi.nlm.nih.gov/27508494/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRR27,ENSG00000187533,Unsafe,37079309,Genome-wide association studies in advanced prostate cancer: KYUCOG-1401-A study.,2023,10.1530/erc-23-0044,https://pubmed.ncbi.nlm.nih.gov/37079309/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,41858337,Investigating the role of FKBP4 in testis germ cell tumor via integrated in silico approach.,2026,10.1007/s40203-026-00592-w,https://pubmed.ncbi.nlm.nih.gov/41858337/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,42900164,The AMPK kinase Sak1 activates separase and promotes its nuclear localization during mitosis.,2026,10.1083/jcb.202505056,https://pubmed.ncbi.nlm.nih.gov/42900164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,40646570,A multi-analyte liquid biopsy approach for nonseminomatous testicular germ cell tumors: combining cfDNA and N-glycan analysis in blood and seminal plasma.,2025,10.1186/s12935-025-03887-8,https://pubmed.ncbi.nlm.nih.gov/40646570/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,37508506,Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry.,2023,10.3390/cells12141841,https://pubmed.ncbi.nlm.nih.gov/37508506/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,38421455,"Spem2, a novel testis-enriched gene, is required for spermiogenesis and fertilization in mice.",2024,10.1007/s00018-024-05147-w,https://pubmed.ncbi.nlm.nih.gov/38421455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,41320334,GATA3 and IFNG as Potential Molecular Biomarkers for Differentiating Heart Failure with Preserved Ejection Fraction with Normal Versus Elevated BNP Levels.,2025,10.1536/ihj.25-159,https://pubmed.ncbi.nlm.nih.gov/41320334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,35774118,A Role of the TEX101 Interactome in the Common Aetiology Behind Male Subfertility and Testicular Germ Cell Tumor.,2022,10.3389/fonc.2022.892043,https://pubmed.ncbi.nlm.nih.gov/35774118/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,40758203,Development and Validation of an Explainable MRI-Based Habitat Radiomics Model for Predicting p53-Abnormal Endometrial Cancer: A Multicentre Feasibility Study.,2026,10.1007/s10278-025-01631-2,https://pubmed.ncbi.nlm.nih.gov/40758203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,40464038,Prospective Evaluation of RedTouch Laser in the Treatment of Dry Eye Disease Secondary to Meibomian Gland Dysfunction.,2025,10.2147/opth.s519700,https://pubmed.ncbi.nlm.nih.gov/40464038/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,41492040,Intratumoral and peritumoral radiomics for the pretreatment prediction of response to neoadjuvant chemotherapy in rhabdomyosarcoma: a multicenter retrospective cohort study.,2026,10.1186/s13244-025-02178-0,https://pubmed.ncbi.nlm.nih.gov/41492040/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,39577426,Impaired pheromone detection and abnormal sexual behavior in female mice deficient for ancV1R.,2025,10.1016/j.cub.2024.10.077,https://pubmed.ncbi.nlm.nih.gov/39577426/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,39580376,Stage-Specific Tumoral Gene Expression Profiles of Black and White Patients with Colon Cancer.,2025,10.1245/s10434-024-16550-9,https://pubmed.ncbi.nlm.nih.gov/39580376/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,38969798,AI models predicting breast cancer distant metastasis using LightGBM with clinical blood markers and ultrasound maximum diameter.,2024,10.1038/s41598-024-66658-x,https://pubmed.ncbi.nlm.nih.gov/38969798/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,40185919,CT-based radiomics deep learning signatures for non-invasive prediction of metastatic potential in pheochromocytoma and paraganglioma: a multicohort study.,2025,10.1186/s13244-025-01952-4,https://pubmed.ncbi.nlm.nih.gov/40185919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,40845156,An innovative peptide toxicity prediction model based on multi-scale convolutional neural network and residual connection.,2025,10.1093/bioinformatics/btaf462,https://pubmed.ncbi.nlm.nih.gov/40845156/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,33224314,In Search of TGCT Biomarkers: A Comprehensive In Silico and Histopathological Analysis.,2020,10.1155/2020/8841880,https://pubmed.ncbi.nlm.nih.gov/33224314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,36247727,Prelimbic cortex responds to male ultrasonic vocalizations in the presence of a male pheromone in female mice.,2022,10.3389/fncir.2022.956201,https://pubmed.ncbi.nlm.nih.gov/36247727/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,32511276,Testisin/Prss21 deficiency causes increased vascular permeability and a hemorrhagic phenotype during luteal angiogenesis.,2020,10.1371/journal.pone.0234407,https://pubmed.ncbi.nlm.nih.gov/32511276/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,34540835,"Identification of ARHGEF38, NETO2, GOLM1, and SAPCD2 Associated With Prostate Cancer Progression by Bioinformatic Analysis and Experimental Validation.",2021,10.3389/fcell.2021.718638,https://pubmed.ncbi.nlm.nih.gov/34540835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,35754804,Relationship Between CNVs and Immune Cells Infiltration in Gastric Tumor Microenvironment.,2022,10.3389/fgene.2022.869967,https://pubmed.ncbi.nlm.nih.gov/35754804/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,39661722,Three-way comparison of different ESR measurement methods and analytical performance assessment of TEST1 automated ESR analyzer.,2025,10.1515/dx-2024-0158,https://pubmed.ncbi.nlm.nih.gov/39661722/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,40811365,ACP-ESM2: Enhancing Anticancer Peptide Prediction With Pre-Trained Protein Language Models.,2025,10.1109/tcbbio.2025.3547952,https://pubmed.ncbi.nlm.nih.gov/40811365/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,41900535,Beyond the Disc: Positional Differences in Morphological and Physical Performance Characteristics Among Male Ultimate Frisbee Players.,2026,10.3390/jfmk11010128,https://pubmed.ncbi.nlm.nih.gov/41900535/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,37120631,Use of machine learning-based integration to develop an immune-related signature for improving prognosis in patients with gastric cancer.,2023,10.1038/s41598-023-34291-9,https://pubmed.ncbi.nlm.nih.gov/37120631/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,37312278,Pelvic + Anatomy: A new interactive pelvic anatomy model. Prospective randomized control trial with first-year midwife residents.,2023,10.1002/ase.2304,https://pubmed.ncbi.nlm.nih.gov/37312278/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,34896053,The Effect of a Microlearning Module on Knowledge Acquisition in Surgery Clerkship Students.,2022,10.1016/j.jsurg.2021.11.001,https://pubmed.ncbi.nlm.nih.gov/34896053/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,37238607,Epigenetic and Tumor Microenvironment for Prognosis of Patients with Gastric Cancer.,2023,10.3390/biom13050736,https://pubmed.ncbi.nlm.nih.gov/37238607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,36810142,The Factors Affecting the Postnatal Bonding of Mothers Whose Babies were Admitted to the Neonatal Intensive Care Unit During the COVID-19 Pandemic.,2023,10.5152/turkarchpediatr.2023.22104,https://pubmed.ncbi.nlm.nih.gov/36810142/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,31725953,Analytical validation of the iSED automated analyzer for erythrocyte sedimentation rate.,2020,10.1111/ijlh.13120,https://pubmed.ncbi.nlm.nih.gov/31725953/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,34804955,"Gastrointestinal Goblet Cell Adenocarcinomas Harbor Distinctive Clinicopathological, Immune, and Genomic Landscape.",2021,10.3389/fonc.2021.758643,https://pubmed.ncbi.nlm.nih.gov/34804955/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,25309342,Lacrimal gland removal impairs sexual behavior in mice.,2014,10.3389/fnana.2014.00101,https://pubmed.ncbi.nlm.nih.gov/25309342/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,33663974,Is it necessary to perform occupational audiometric testing at 6-months of employment?,2022,10.1016/j.bjorl.2020.12.008,https://pubmed.ncbi.nlm.nih.gov/33663974/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,24493848,"Long-term expression of human contextual fear and extinction memories involves amygdala, hippocampus and ventromedial prefrontal cortex: a reinstatement study in two independent samples.",2014,10.1093/scan/nsu018,https://pubmed.ncbi.nlm.nih.gov/24493848/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PRSS21,ENSG00000007038,Unsafe,19944647,Immune response to Mycobacterium tuberculosis specific antigen ESAT-6 among south Indians.,2010,10.1016/j.tube.2009.10.003,https://pubmed.ncbi.nlm.nih.gov/19944647/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42735931,PSEN1 Expression Identifies a Developmentally Distinct Favourable-Prognosis State in SHH α Medulloblastoma.,2026,10.1002/jdn.70178,https://pubmed.ncbi.nlm.nih.gov/42735931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42908768,"The influence of mutant genes APP and PSEN1 on hippocampal asymmetry in 5xFAD mice, transgenic model of Alzheimer disease.",2026,10.18699/vjgb-26-92,https://pubmed.ncbi.nlm.nih.gov/42908768/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42292846,"Pharmacology of nivegacetor (RG6289), a potent and selective gamma secretase modulator in clinical development for the treatment of Alzheimer's disease.",2026,10.3389/fphar.2026.1783414,https://pubmed.ncbi.nlm.nih.gov/42292846/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,41496612,"Presenilin L166P Mutation, a Model of Familial Alzheimer's Disease, Leads to Early Onset Bone Loss.",2026,10.1002/cph4.70097,https://pubmed.ncbi.nlm.nih.gov/41496612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42278518,"ZL006 Treatment Reduces Inflammation, Oxidative Stress, and Brain Aβ&lt;sub&gt;1-42&lt;/sub&gt; Accumulation and Rescues the Loss of PSD95 Synaptic Marker in Familial Alzheimer's Disease-Associated &lt;i&gt;psen1&lt;/i&gt;-Deficient Zebrafish Model.",2026,10.3390/ijms27114992,https://pubmed.ncbi.nlm.nih.gov/42278518/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42653368,Human Stem Cell-Derived Models of the Alzheimer's Disease Neuroimmune System.,2026,10.3390/ijms27167360,https://pubmed.ncbi.nlm.nih.gov/42653368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42334726,A Humanized Knock-in Mouse Model of the PSEN1 V97L Mutation from a Major Chinese Alzheimer's Disease Pedigree Reveals Early Neuroinflammation.,2026,10.1007/s12264-026-01656-9,https://pubmed.ncbi.nlm.nih.gov/42334726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42477212,Patient-Derived PSEN1 Cerebral Organoids Revealed Parallel Development of Amyloid-β Accumulation and Network Dysfunction.,2026,10.1007/s10571-026-01779-7,https://pubmed.ncbi.nlm.nih.gov/42477212/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,41508098,Interpretable machine-learning prediction of PSEN1 missense variant pathogenicity based on multi-omics enrichment in six core Alzheimer's disease genes.,2026,10.1186/s13195-025-01950-0,https://pubmed.ncbi.nlm.nih.gov/41508098/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42896796,Exploratory chromosome 14-focused transcriptomic profiling of PSEN1-associated familial Alzheimer's disease across brain regions.,2026,10.1016/j.bbapap.2026.141192,https://pubmed.ncbi.nlm.nih.gov/42896796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,41958553,Cognitive dysfunction in patients with interstitial lung disease.,2026,10.3389/fmed.2026.1739386,https://pubmed.ncbi.nlm.nih.gov/41958553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42488555,"Modeling Alzheimer's disease with brain organoids: mechanisms, applications, and future directions.",2026,10.3389/fcell.2026.1791272,https://pubmed.ncbi.nlm.nih.gov/42488555/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,41699702,Mutations associated with Alzheimer's disease and aged serum synergistically elicit blood-brain barrier dysfunction in a tissue-engineered model.,2026,10.1186/s12987-026-00773-x,https://pubmed.ncbi.nlm.nih.gov/41699702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,41131557,"Differential impact of manganese on glutamate clearance, electroencephalography, and sleep in Alzheimer's disease.",2025,10.1002/alz.70821,https://pubmed.ncbi.nlm.nih.gov/41131557/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,41127441,The curious case of a heterozygous loss-of-function &lt;i&gt;PSEN1&lt;/i&gt; variant associated with early-onset Alzheimer's disease.,2025,10.1186/s44477-025-00004-x,https://pubmed.ncbi.nlm.nih.gov/41127441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42709289,"Dexpanthenol Attenuates High Fructose Corn Syrup-Induced Brain Injury by Modulating Oxidative Stress, Neuroinflammation, Apoptotic Signaling and Amyloidogenic Gene Expression.",2026,10.1007/s12035-026-06176-1,https://pubmed.ncbi.nlm.nih.gov/42709289/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,41679193,Region-specific brain structural modulation and amyloid-β pathology associated with dietary biotin: insights into dementia neuropathology.,2026,10.1016/j.ebiom.2026.106155,https://pubmed.ncbi.nlm.nih.gov/41679193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42922412,Deanna Protocol Ameliorates the Deficits in Human iPSC-Cortical Neurons Carrying Familial Alzheimer's Mutation. ,2026,10.1002/cns.71205,https://pubmed.ncbi.nlm.nih.gov/42922412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42476773,A Novel p. (Leu173del) Mutation in the Presenilin 1 (PSEN1) Gene in Two Sisters with Dominantly Inherited Alzheimer's Disease.,2026,10.2169/internalmedicine.7327-26,https://pubmed.ncbi.nlm.nih.gov/42476773/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,41675007,The preliminary study on the effect of PSEN1 on the proliferation and invasion of breast cancer cells.,2026,10.21037/tbcr-25-42,https://pubmed.ncbi.nlm.nih.gov/41675007/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,39989768,Newer Therapeutic Approaches in Treating Alzheimer's Disease: A Comprehensive Review.,2025,10.1021/acsomega.4c05527,https://pubmed.ncbi.nlm.nih.gov/39989768/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42676462,"Lecanemab in symptomatic PSEN1 p.Met233Val early-onset Alzheimer's disease: Neuroimaging safety, regional amyloid-PET dynamics, and longitudinal plasma biomarkers.",2026,10.1002/dad2.70468,https://pubmed.ncbi.nlm.nih.gov/42676462/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42468111,"Baseline and placebo-related imaging, cerebrospinal fluid, plasma biomarker, and cognitive findings in unimpaired PSEN1 E280A mutation carriers and non-carriers in the Alzheimer's Prevention Initiative Autosomal Dominant Alzheimer's Disease Colombia Trial.",2026,10.1016/j.ebiom.2026.106390,https://pubmed.ncbi.nlm.nih.gov/42468111/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,41694355,Novel prognostic signature unveils PSEN1 contributes to depression-induced lung adenocarcinoma progression.,2026,10.3389/fimmu.2026.1681306,https://pubmed.ncbi.nlm.nih.gov/41694355/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,41870777,Bridging the gaps in alzheimer's disease: a comprehensive review of current and emerging therapies.,2026,10.1007/s10787-026-02151-3,https://pubmed.ncbi.nlm.nih.gov/41870777/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,40795314,Restoring amyloid-β42 and γ-secretase function in Alzheimer's disease.,2025,10.1093/brain/awaf294,https://pubmed.ncbi.nlm.nih.gov/40795314/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42200309,Reduced SH3RF3 May Protect Against Alzheimer's Disease by Lowering Microglial Pro-Inflammatory Responses via Modulation of JNK and NFkB Signaling.,2026,10.1002/glia.70165,https://pubmed.ncbi.nlm.nih.gov/42200309/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,41579901,"Safety and efficacy of crenezumab in cognitively unimpaired carriers of the PSEN1&lt;sup&gt;Glu280Ala&lt;/sup&gt; mutation at risk for autosomal-dominant Alzheimer's disease in Colombia (API ADAD Colombia Trial): a phase 2, randomised, double-blind, placebo-controlled trial.",2026,10.1016/s1474-4422(25)00426-0,https://pubmed.ncbi.nlm.nih.gov/41579901/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42650158,Genetic Architecture of Synaptic Failure in Dementia with Lewy Bodies: From α-Synuclein Proteoforms to GBA1-Mediated Plasticity Deficits.,2026,10.3390/genes17080965,https://pubmed.ncbi.nlm.nih.gov/42650158/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42521900,Integrative network pharmacology and molecular dynamics analysis of a curcumin-indole-3-propionic acid conjugate for diabetes-associated cognitive decline.,2026,10.1007/s10867-026-09721-0,https://pubmed.ncbi.nlm.nih.gov/42521900/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42430332,"NavegApp, a serious game for assessing spatial cognition: Diagnostic accuracy in preclinical and prodromal Alzheimer's disease.",2026,10.1371/journal.pdig.0001521,https://pubmed.ncbi.nlm.nih.gov/42430332/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,41474988,Papaverine-Derived Dual-Active Modulator Ameliorates Alzheimer's Disease Pathology in Aged APP/PSEN1 Transgenic Mice.,2026,10.1021/acs.jmedchem.5c03360,https://pubmed.ncbi.nlm.nih.gov/41474988/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,42090736,Associations of plasma biomarkers with age in the presenilin-1 E280A autosomal dominant Alzheimer's disease kindred.,2026,10.1016/j.tjpad.2026.100578,https://pubmed.ncbi.nlm.nih.gov/42090736/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,40255471,Single-Cell Transcriptional Analysis Reveals the Mechanism of AZD6738 in HCC Immunotherapy via EZH2 Targeting.,2025,10.2147/dddt.s508709,https://pubmed.ncbi.nlm.nih.gov/40255471/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,40281586,"Spectrum of γ-Secretase dysfunction as a unifying predictor of ADAD age at onset across PSEN1, PSEN2 and APP causal genes.",2025,10.1186/s13024-025-00832-1,https://pubmed.ncbi.nlm.nih.gov/40281586/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,11987239,Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules.,2002,10.1006/bcmd.2002.0486,https://pubmed.ncbi.nlm.nih.gov/11987239/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,8574969,Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.,1996,10.1038/nm0296-224,https://pubmed.ncbi.nlm.nih.gov/8574969/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,8641442,"Identification and characterization of presenilin I-467, I-463 and I-374.",1996,10.1016/0014-5793(96)00054-3,https://pubmed.ncbi.nlm.nih.gov/8641442/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSEN1,ENSG00000080815,Unsafe,7596406,Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.,1995,10.1038/375754a0,https://pubmed.ncbi.nlm.nih.gov/7596406/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,41796334,Endogenous retroviral elements LTR8B and MER65 rewire PSG9 regulation to control trophoblast syncytialization and pre-eclampsia risk.,2026,10.1186/s13059-026-03944-z,https://pubmed.ncbi.nlm.nih.gov/41796334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,42725300,Unmasking the invisible: Proteomic traces of depression in human serum - A pilot study.,2026,10.4103/indianjpsychiatry_975_25,https://pubmed.ncbi.nlm.nih.gov/42725300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,39893742,Molecular changes of cellular senescence in dental pulp stem cells during in vitro culture: A potential role of PSG4.,2025,10.1016/j.tice.2025.102758,https://pubmed.ncbi.nlm.nih.gov/39893742/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,41717762,"Portable ""dual-signal-on"" colorimetric and photothermal biosensor for accurate detection of Hg&lt;sup&gt;2+&lt;/sup&gt; based on split Cas12a-mediated cascade strand displacement and phosphorothioate-modified G-quadruplex DNAzyme.",2026,10.1039/d5ay01924a,https://pubmed.ncbi.nlm.nih.gov/41717762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,40848498,A fluorescent aptasensor for accurate and sensitive detection of glyphosate based on asymmetrically competitive CRISPR/Cas12a with phosphorothioate-modified G-quadruplex.,2026,10.1016/j.saa.2025.126840,https://pubmed.ncbi.nlm.nih.gov/40848498/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,39613308,Novel Placental Biomarker Shows Predictive Potential for Spontaneous Preterm Labor.,2025,10.1055/a-2491-4391,https://pubmed.ncbi.nlm.nih.gov/39613308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,36980442,Pregnancy-Specific Glycoprotein 9 Enhances Store-Operated Calcium Entry and Nitric Oxide Release in Human Umbilical Vein Endothelial Cells.,2023,10.3390/diagnostics13061134,https://pubmed.ncbi.nlm.nih.gov/36980442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,39796238,The Molecular Biology of Placental Transport of Calcium to the Human Foetus.,2025,10.3390/ijms26010383,https://pubmed.ncbi.nlm.nih.gov/39796238/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,40948775,Novel proteomics biomarkers of recurrent pregnancy loss reflect the dysregulation of immune interactions at the maternal-fetal interface.,2025,10.3389/fimmu.2025.1621168,https://pubmed.ncbi.nlm.nih.gov/40948775/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,33452729,Depletion of CTCF disrupts PSG gene expression in the human trophoblast cell line Swan 71.,2021,10.1002/2211-5463.13087,https://pubmed.ncbi.nlm.nih.gov/33452729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,38740457,Phosphorothioate-modified G-quadruplex as a signal-on dual-mode reporter for CRISPR/Cas12a-based portable detection of environmental pollutants.,2024,10.1016/j.aca.2024.342649,https://pubmed.ncbi.nlm.nih.gov/38740457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,35322669,PSG7 and 9 (Pregnancy-Specific β-1 Glycoproteins 7 and 9): Novel Biomarkers for Preeclampsia.,2022,10.1161/jaha.121.024536,https://pubmed.ncbi.nlm.nih.gov/35322669/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,33377651,Pregnancy-specific glycoprotein 9 acts as both a transcriptional target and a regulator of the canonical TGF-β/Smad signaling to drive breast cancer progression.,2020,10.1002/ctm2.245,https://pubmed.ncbi.nlm.nih.gov/33377651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,35401843,Effects of Pregnancy-Specific Glycoproteins on Trophoblast Motility in Three-Dimensional Gelatin Hydrogels.,2022,10.1007/s12195-021-00715-7,https://pubmed.ncbi.nlm.nih.gov/35401843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,33824285,TFAP2A potentiates lung adenocarcinoma metastasis by a novel miR-16 family/TFAP2A/PSG9/TGF-β signaling pathway.,2021,10.1038/s41419-021-03606-x,https://pubmed.ncbi.nlm.nih.gov/33824285/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,37715129,Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy.,2023,10.1186/s12014-023-09425-w,https://pubmed.ncbi.nlm.nih.gov/37715129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,27528036,"Pregnancy-specific glycoprotein 9 (PSG9), a driver for colorectal cancer, enhances angiogenesis via activation of SMAD4.",2016,10.18632/oncotarget.11146,https://pubmed.ncbi.nlm.nih.gov/27528036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,32953262,Serum proteins differentially expressed in early- and late-onset preeclampsia assessed using iTRAQ proteomics and bioinformatics analyses.,2020,10.7717/peerj.9753,https://pubmed.ncbi.nlm.nih.gov/32953262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,33857242,Proteomic identification of biomarkers in maternal plasma that predict the outcome of rescue cerclage for cervical insufficiency.,2021,10.1371/journal.pone.0250031,https://pubmed.ncbi.nlm.nih.gov/33857242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,27389696,PSG9 Stimulates Increase in FoxP3+ Regulatory T-Cells through the TGF-β1 Pathway.,2016,10.1371/journal.pone.0158050,https://pubmed.ncbi.nlm.nih.gov/27389696/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,30371828,"Activation of latent transforming growth factor-β1, a conserved function for pregnancy-specific beta 1-glycoproteins.",2018,10.1093/molehr/gay044,https://pubmed.ncbi.nlm.nih.gov/30371828/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,26896894,"Octylphenol induced gene expression in testes of Frog, Rana chensinensis.",2016,10.1016/j.ecoenv.2016.02.013,https://pubmed.ncbi.nlm.nih.gov/26896894/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG4,ENSG00000243137,Unsafe,27447975,Molecular mechanisms of OLIG2 transcription factor in brain cancer.,2016,10.18632/oncotarget.10628,https://pubmed.ncbi.nlm.nih.gov/27447975/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,42133059,Evaluation of vector system in Saccharopolyspora erythraea and construction of new replicative vector.,2026,10.1007/s00253-026-13858-2,https://pubmed.ncbi.nlm.nih.gov/42133059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,39572673,Identification of novel drug targets for liver cirrhosis and its potential side-effects by human plasma proteome.,2024,10.1038/s41598-024-80483-2,https://pubmed.ncbi.nlm.nih.gov/39572673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,37999386,Chitosan-Based Sustained Expression of Sterol Regulatory Element-Binding Protein 1a Stimulates Hepatic Glucose Oxidation and Growth in Sparus aurata.,2023,10.3390/md21110562,https://pubmed.ncbi.nlm.nih.gov/37999386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,38745021,Transcriptomic characteristics according to tumor size and SUVmax in papillary thyroid cancer patients.,2024,10.1038/s41598-024-61839-0,https://pubmed.ncbi.nlm.nih.gov/38745021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,36397112,The prognostic value of tumor mutational burden related 6-gene-based Risk Score in laryngeal cancer patients.,2022,10.1186/s12903-022-02534-2,https://pubmed.ncbi.nlm.nih.gov/36397112/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,37012406,Regulation of human trophoblast gene expression by endogenous retroviruses.,2023,10.1038/s41594-023-00960-6,https://pubmed.ncbi.nlm.nih.gov/37012406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,38775562,Unravelling the molecular landscape of endometrial cancer subtypes: insights from multiomics analysis.,2024,10.1097/js9.0000000000001685,https://pubmed.ncbi.nlm.nih.gov/38775562/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,33452729,Depletion of CTCF disrupts PSG gene expression in the human trophoblast cell line Swan 71.,2021,10.1002/2211-5463.13087,https://pubmed.ncbi.nlm.nih.gov/33452729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,34880956,Identification of KLF6/PSGs and NPY-Related USF2/CEACAM Transcriptional Regulatory Networks via Spinal Cord Bulk and Single-Cell RNA-Seq Analysis.,2021,10.1155/2021/2826609,https://pubmed.ncbi.nlm.nih.gov/34880956/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,30191290,The pSG5-based thermosensitive vector family for genome editing and gene expression in actinomycetes.,2018,10.1007/s00253-018-9334-5,https://pubmed.ncbi.nlm.nih.gov/30191290/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,30891508,Efficient editing DNA regions with high sequence identity in actinomycetal genomes by a CRISPR-Cas9 system.,2019,10.1016/j.synbio.2019.02.004,https://pubmed.ncbi.nlm.nih.gov/30891508/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,38647752,Two strategies to improve the supply of PKS extender units for ansamitocin P-3 biosynthesis by CRISPR-Cas9.,2022,10.1186/s40643-022-00583-7,https://pubmed.ncbi.nlm.nih.gov/38647752/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,29930344,Krüppel-Like Factor 10 participates in cervical cancer immunoediting through transcriptional regulation of Pregnancy-Specific Beta-1 Glycoproteins.,2018,10.1038/s41598-018-27711-8,https://pubmed.ncbi.nlm.nih.gov/29930344/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,33048369,DNA methylation determines the regulation of pregnane X receptor on CYP3A4 expression.,2021,10.1111/1440-1681.13420,https://pubmed.ncbi.nlm.nih.gov/33048369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,29225627,Isolation and Molecular Characterization of Amniotic Fluid-Derived Mesenchymal Stem Cells Obtained from Caesarean Sections.,2017,10.1155/2017/5932706,https://pubmed.ncbi.nlm.nih.gov/29225627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,31912451,Development of a gene expression system for the uncommon actinomycete Actinoplanes rectilineatus NRRL B-16090.,2020,10.1007/s13353-019-00534-7,https://pubmed.ncbi.nlm.nih.gov/31912451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,34635074,Differences in genetics and microenvironment of lung adenocarcinoma patients with or without TP53 mutation.,2021,10.1186/s12890-021-01671-8,https://pubmed.ncbi.nlm.nih.gov/34635074/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,26874000,KLF6 cooperates with NUR77 and SF1 to activate the human INSL3 promoter in mouse MA-10 leydig cells.,2016,10.1530/jme-15-0139,https://pubmed.ncbi.nlm.nih.gov/26874000/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,32117443,Identification of the Prognosis-Related lncRNAs and Genes in Gastric Cancer.,2020,10.3389/fgene.2020.00027,https://pubmed.ncbi.nlm.nih.gov/32117443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,31253141,Evaluation of vector systems and promoters for overexpression of the acarbose biosynthesis gene acbC in Actinoplanes sp. SE50/110.,2019,10.1186/s12934-019-1162-5,https://pubmed.ncbi.nlm.nih.gov/31253141/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,29168799,"Modulation of Cytochrome P450, P-glycoprotein and Pregnane X Receptor by Selected Antimalarial Herbs-Implication for Herb-Drug Interaction.",2017,10.3390/molecules22122049,https://pubmed.ncbi.nlm.nih.gov/29168799/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,17392589,Modification of Cepsilon mRNA expression by EBV-encoded latent membrane protein 1.,2006,10.1155/mi/2006/68069,https://pubmed.ncbi.nlm.nih.gov/17392589/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,12744896,"A comparison of DNA vaccines for the rabies-related virus, Mokola.",2003,10.1016/s0264-410x(03)00036-7,https://pubmed.ncbi.nlm.nih.gov/12744896/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSG5,ENSG00000204941,Unsafe,8551602,Analysis of a nuclear localization signal of simian virus 40 major capsid protein Vp1.,1996,10.1128/jvi.70.2.1317-1322.1996,https://pubmed.ncbi.nlm.nih.gov/8551602/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSKH2,ENSG00000147613,Unsafe,39424413,Genome-Wide Search for Nonadditive Allele Effects Identifies &lt;i&gt;PSKH2&lt;/i&gt; as Involved in the Variability of Factor V Activity.,2024,10.1161/jaha.124.034943,https://pubmed.ncbi.nlm.nih.gov/39424413/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSKH2,ENSG00000147613,Unsafe,36520605,Evolutionary and cellular analysis of the 'dark' pseudokinase PSKH2.,2023,10.1042/bcj20220474,https://pubmed.ncbi.nlm.nih.gov/36520605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSKH2,ENSG00000147613,Unsafe,38755266,Prediction models of persistent taxane-induced peripheral neuropathy among breast cancer survivors using whole-exome sequencing.,2024,10.1038/s41698-024-00594-x,https://pubmed.ncbi.nlm.nih.gov/38755266/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSKH2,ENSG00000147613,Unsafe,32053275,Cataloguing the dead: breathing new life into pseudokinase research.,2020,10.1111/febs.15246,https://pubmed.ncbi.nlm.nih.gov/32053275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,42071808,"Analysis of core target genes of vagus nerve stimulation in epilepsy, ischemic stroke, and depression: Separate insights from network pharmacology, bioinformatics, and Mendelian randomization.",2026,10.1097/md.0000000000048332,https://pubmed.ncbi.nlm.nih.gov/42071808/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,39794329,PSMA2 promotes chemo- and radioresistance of oral squamous cell carcinoma by modulating mitophagy pathway.,2025,10.1038/s41420-025-02286-2,https://pubmed.ncbi.nlm.nih.gov/39794329/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,42412755,Discovery of hub genes linking oxidative stress to type 2 diabetic sarcopenia using single-cell sequencing and machine learning.,2026,10.1371/journal.pone.0352753,https://pubmed.ncbi.nlm.nih.gov/42412755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,40910197,Prognostic Value and Immune Characterization of Genes Associated with Childhood Acute Leukemia applying Single-Cell RNA Sequencing.,2026,10.2174/0118715303420113250818064855,https://pubmed.ncbi.nlm.nih.gov/40910197/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,40923709,The Proteomic Profiling of Circulating Extracellular Vesicles of Western Diet and Chemical-Induced Murine MASH Model.,2026,10.1002/kjm2.70107,https://pubmed.ncbi.nlm.nih.gov/40923709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,40890357,Construction of a prognostic risk model for acute myeloid leukemia based on exosomal genes and analysis of immune microenvironment characteristics.,2025,10.1038/s41598-025-17845-x,https://pubmed.ncbi.nlm.nih.gov/40890357/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,42016605,Effects of &lt;i&gt;rok1&lt;/i&gt; gene deletion on mitosis in fission yeast at appropriate and stressful temperatures and the molecular mechanisms.,2026,10.3892/etm.2026.13145,https://pubmed.ncbi.nlm.nih.gov/42016605/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,41131760,[Protein biomarker screening and functional analysis of salivary exosomes in patients with ulcerative colitis].,2025,10.19723/j.issn.1671-167x.2025.05.013,https://pubmed.ncbi.nlm.nih.gov/41131760/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,42602792,"Dietary L-carnosine enhances the growth, muscle hardness and protein deposition in red swamp crayfish (&lt;i&gt;Procambarus clarkii&lt;/i&gt;).",2026,10.1016/j.aninu.2026.01.018,https://pubmed.ncbi.nlm.nih.gov/42602792/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,38574629,PSMA2 promotes glioma proliferation and migration via EMT.,2024,10.1016/j.prp.2024.155278,https://pubmed.ncbi.nlm.nih.gov/38574629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,41316520,"METTL14 Regulates the Expression of Genes Related to Interferon, Interleukin and MHC Class I in Nasopharyngeal Carcinoma Cells.",2025,10.1002/cam4.71371,https://pubmed.ncbi.nlm.nih.gov/41316520/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,39737099,Investigates the Role of PANoptosis in Idiopathic Pulmonary Fibrosis and Potential Therapeutic Targets.,2024,10.2147/jir.s490457,https://pubmed.ncbi.nlm.nih.gov/39737099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,40095265,Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons.,2025,10.1007/s10495-025-02097-x,https://pubmed.ncbi.nlm.nih.gov/40095265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,38481252,Development and clinical validation of a seven-gene signature based on tumor stem cell-related genes to predict ovarian cancer prognosis.,2024,10.1186/s13048-023-01326-8,https://pubmed.ncbi.nlm.nih.gov/38481252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,40729310,Discordant effects of maternal age on the human MII oocyte transcriptome.,2025,10.1093/molehr/gaaf038,https://pubmed.ncbi.nlm.nih.gov/40729310/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,39682314,Genome-Wide Association Study and Phenotype Prediction of Reproductive Traits in Large White Pigs.,2024,10.3390/ani14233348,https://pubmed.ncbi.nlm.nih.gov/39682314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,39850819,Rational strategies for designing next-generation oncolytic viruses based on transcriptome analysis of tumor cells infected with oncolytic herpes simplex virus-1.,2024,10.3389/fonc.2024.1469511,https://pubmed.ncbi.nlm.nih.gov/39850819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,42235714,Mechanistic investigation of Guizhi Gancao decoction in alleviating isoproterenol-induced chronic heart failure via inhibition of sarcoplasmic/endoplasmic (SR/ER) reticulum Ca&lt;sup&gt;2+&lt;/sup&gt;-ATPase 2a ubiquitination.,2026,10.1016/j.jep.2026.121858,https://pubmed.ncbi.nlm.nih.gov/42235714/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,36481484,PSMA2 knockdown impacts expression of proteins involved in immune and cellular stress responses in human lung cells.,2023,10.1016/j.bbadis.2022.166617,https://pubmed.ncbi.nlm.nih.gov/36481484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,33684886,Increased co-expression of PSMA2 and GLP-1 receptor in cervical cancer models in type 2 diabetes attenuated by Exendin-4: A translational case-control study.,2021,10.1016/j.ebiom.2021.103242,https://pubmed.ncbi.nlm.nih.gov/33684886/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,38238671,An immune-related exosome signature predicts the prognosis and immunotherapy response in ovarian cancer.,2024,10.1186/s12905-024-02881-y,https://pubmed.ncbi.nlm.nih.gov/38238671/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,38171602,Effectiveness of longstanding exercise therapy compared with usual care for people with rheumatoid arthritis and severe functional limitations: a randomised controlled trial.,2024,10.1136/ard-2023-224912,https://pubmed.ncbi.nlm.nih.gov/38171602/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,37222809,Analysis of prognostic biomarker models and immune microenvironment in acute myeloid leukemia by integrative bioinformatics.,2023,10.1007/s00432-023-04871-3,https://pubmed.ncbi.nlm.nih.gov/37222809/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,35019712,Influenza A Virus Uses PSMA2 for Downregulation of the NRF2-Mediated Oxidative Stress Response.,2022,10.1128/jvi.01990-21,https://pubmed.ncbi.nlm.nih.gov/35019712/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,33537240,Comprehensively Analyzed Macrophage-Regulated Genes Indicate That PSMA2 Promotes Colorectal Cancer Progression.,2020,10.3389/fonc.2020.618902,https://pubmed.ncbi.nlm.nih.gov/33537240/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,36680137,"HLA-A, HSPA5, IGFBP5 and PSMA2 Are Restriction Factors for Zika Virus Growth in Astrocytic Cells.",2022,10.3390/v15010097,https://pubmed.ncbi.nlm.nih.gov/36680137/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,39342401,Diminished expression of the ubiquitin-proteasome system in early treatment-naïve patients with rheumatoid arthritis and concomitant type 2 diabetes may be linked to IL-1 pathway hyper-activity; results from PEAC cohort.,2024,10.1186/s13075-024-03392-9,https://pubmed.ncbi.nlm.nih.gov/39342401/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,35938038,"Evaluating the Prognostic and Therapeutic Potentials of the Proteasome 26S Subunit, ATPase (PSMC) Family of Genes in Lung Adenocarcinoma: A Database Mining Approach.",2022,10.3389/fgene.2022.935286,https://pubmed.ncbi.nlm.nih.gov/35938038/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,34943457,Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer.,2021,10.3390/diagnostics11122220,https://pubmed.ncbi.nlm.nih.gov/34943457/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,31151297,Identification of Proteins Differentially Expressed by Adipose-derived Mesenchymal Stem Cells Isolated from Immunodeficient Mice.,2019,10.3390/ijms20112672,https://pubmed.ncbi.nlm.nih.gov/31151297/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMA2,ENSG00000106588,Unsafe,32042826,Differential expression of genes associated with T lymphocytes function in septic patients with hypoxemia challenge.,2019,10.21037/atm.2019.12.63,https://pubmed.ncbi.nlm.nih.gov/32042826/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMB11,ENSG00000222028,Unsafe,42261593,Thymic cortical epithelial Psmb11-encoded β5t in mouse and human.,2026,10.1093/intimm/dxag031,https://pubmed.ncbi.nlm.nih.gov/42261593/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMB11,ENSG00000222028,Unsafe,42840284,Epigenetic profiling of preterm birth: a dual-tissue methylation patterns using long-read sequencing.,2025,10.3389/freae.2025.1644521,https://pubmed.ncbi.nlm.nih.gov/42840284/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMB11,ENSG00000222028,Unsafe,34496243,PSMB11 regulates gene expression in cortical thymic epithelial cells.,2021,10.1016/j.celrep.2021.109546,https://pubmed.ncbi.nlm.nih.gov/34496243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMB11,ENSG00000222028,Unsafe,37180153,Klf4 protects thymus integrity during late pregnancy.,2023,10.3389/fimmu.2023.1016378,https://pubmed.ncbi.nlm.nih.gov/37180153/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMB11,ENSG00000222028,Unsafe,33537838,Thymus and autoimmunity.,2021,10.1007/s00281-021-00842-3,https://pubmed.ncbi.nlm.nih.gov/33537838/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMB11,ENSG00000222028,Unsafe,30567730,PSMB11 Orchestrates the Development of CD4 and CD8 Thymocytes via Regulation of Gene Expression in Cortical Thymic Epithelial Cells.,2019,10.4049/jimmunol.1801288,https://pubmed.ncbi.nlm.nih.gov/30567730/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMB11,ENSG00000222028,Unsafe,28515360,A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production.,2017,10.1172/jci.insight.93664,https://pubmed.ncbi.nlm.nih.gov/28515360/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMB11,ENSG00000222028,Unsafe,36375838,Diversity in Cortical Thymic Epithelial Cells Occurs through Loss of a Foxn1-Dependent Gene Signature Driven by Stage-Specific Thymocyte Cross-Talk.,2023,10.4049/jimmunol.2200609,https://pubmed.ncbi.nlm.nih.gov/36375838/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMB11,ENSG00000222028,Unsafe,31447097,"Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis.",2019,10.1016/j.ajhg.2019.07.014,https://pubmed.ncbi.nlm.nih.gov/31447097/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMB11,ENSG00000222028,Unsafe,30038304,Fundamental parameters of the developing thymic epithelium in the mouse.,2018,10.1038/s41598-018-29460-0,https://pubmed.ncbi.nlm.nih.gov/30038304/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMB11,ENSG00000222028,Unsafe,26250469,Sex hormones have pervasive effects on thymic epithelial cells.,2015,10.1038/srep12895,https://pubmed.ncbi.nlm.nih.gov/26250469/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMB11,ENSG00000222028,Unsafe,21748441,Comparative genomic analysis of the proteasome β5t subunit gene: implications for the origin and evolution of thymoproteasomes.,2012,10.1007/s00251-011-0558-0,https://pubmed.ncbi.nlm.nih.gov/21748441/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMB11,ENSG00000222028,Unsafe,27493218,Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution.,2016,10.1073/pnas.1607602113,https://pubmed.ncbi.nlm.nih.gov/27493218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMB11,ENSG00000222028,Unsafe,21354627,Evolutionary conserved pro-inflammatory and antigen presentation functions of zebrafish IFNγ revealed by transcriptomic and functional analysis.,2011,10.1016/j.molimm.2011.01.015,https://pubmed.ncbi.nlm.nih.gov/21354627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSMB11,ENSG00000222028,Unsafe,28783658,Human thymoproteasome variations influence CD8 T cell selection.,2017,10.1126/sciimmunol.aan5165,https://pubmed.ncbi.nlm.nih.gov/28783658/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,42507215,Characterizing risk groups in papillary thyroid carcinoma through T-Cell mediated tumor cell killing-related genes: a pathway to therapeutic predictions.,2026,10.1007/s00405-026-10470-y,https://pubmed.ncbi.nlm.nih.gov/42507215/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,42796028,Gene Expression Signatures Associated with Pterygium Recurrence.,2026,10.3390/jcm15187257,https://pubmed.ncbi.nlm.nih.gov/42796028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,40870966,Genotype Frequency of &lt;i&gt;HLA-B*58:01&lt;/i&gt; and Its Association with Paraclinical Characteristics and &lt;i&gt;PSORS1C1&lt;/i&gt; rs9263726 in Gout Patients.,2025,10.3390/diagnostics15162114,https://pubmed.ncbi.nlm.nih.gov/40870966/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,42448100,Genetic analysis of HLA-B*27 anterior uveitis in patients presenting either acute or chronic anterior uveitis among Northern Thai populations.,2026,10.1016/j.exer.2026.111167,https://pubmed.ncbi.nlm.nih.gov/42448100/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,41346622,Pharmacogenomic landscape of TNF inhibitors in the Middle Eastern Qatari population.,2025,10.3389/fimmu.2025.1674889,https://pubmed.ncbi.nlm.nih.gov/41346622/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,35626191,PSORS1 Locus Genotyping Profile in Psoriasis: A Pilot Case-Control Study.,2022,10.3390/diagnostics12051035,https://pubmed.ncbi.nlm.nih.gov/35626191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,37265963,Refined expression quantitative trait locus analysis on adenocarcinoma at the gastroesophageal junction reveals susceptibility and prognostic markers.,2023,10.3389/fgene.2023.1180500,https://pubmed.ncbi.nlm.nih.gov/37265963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,37453912,Identification of B-cell-related HSPG2 and CDSN as susceptibility loci for Kawasaki disease.,2023,10.1016/j.humimm.2023.07.001,https://pubmed.ncbi.nlm.nih.gov/37453912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,34325607,Psoriasis Susceptibility 1 Candidate 1 (PSORS1C1) Polymorphism is Associated with Autoimmune Thyroid Disease in a Chinese Han Population.,2022,10.1080/08820139.2021.1923734,https://pubmed.ncbi.nlm.nih.gov/34325607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,34414410,Detecting methylation quantitative trait loci using a methylation random field method.,2021,10.1093/bib/bbab323,https://pubmed.ncbi.nlm.nih.gov/34414410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,30662464,Clinical Implication and the Hereditary Factors of NM23 in Hepatocellular Carcinoma Based on Bioinformatics Analysis and Genome-Wide Association Study.,2018,10.1155/2018/6594169,https://pubmed.ncbi.nlm.nih.gov/30662464/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,36078103,Contribution from MHC-Mediated Risk in Schizophrenia Can Reflect a More Ethnic-Specific Genetic and Comorbid Background.,2022,10.3390/cells11172695,https://pubmed.ncbi.nlm.nih.gov/36078103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,37456859,A metagenome-wide association study of HIV disease progression in HIV controllers.,2023,10.1016/j.isci.2023.107214,https://pubmed.ncbi.nlm.nih.gov/37456859/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,29589160,"HLA-C*06:02-independent, gender-related association of PSORS1C3 and PSORS1C1/CDSN single-nucleotide polymorphisms with risk and severity of psoriasis.",2018,10.1007/s00438-018-1435-4,https://pubmed.ncbi.nlm.nih.gov/29589160/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,38654296,Influence of pharmacogenomic polymorphisms on allopurinol-induced cutaneous adverse drug reactions in Thai patients.,2024,10.1186/s12920-024-01874-y,https://pubmed.ncbi.nlm.nih.gov/38654296/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,28107378,"Polymorphisms in STAT4, PTPN2, PSORS1C1 and TRAF3IP2 Genes Are Associated with the Response to TNF Inhibitors in Patients with Rheumatoid Arthritis.",2017,10.1371/journal.pone.0169956,https://pubmed.ncbi.nlm.nih.gov/28107378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,30069262,Immune Regulatory Genes Are Major Genetic Factors to Behcet Disease: Systematic Review.,2018,10.2174/1874312901812010070,https://pubmed.ncbi.nlm.nih.gov/30069262/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,30993211,Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.,2019,10.1038/s42003-019-0339-0,https://pubmed.ncbi.nlm.nih.gov/30993211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,27342690,"Polymorphisms in STAT-4, IL-10, PSORS1C1, PTPN2 and MIR146A genes are associated differently with prognostic factors in Italian patients affected by rheumatoid arthritis.",2016,10.1111/cei.12831,https://pubmed.ncbi.nlm.nih.gov/27342690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,29387007,PSORS1C1 Hypomethylation Is Associated with Allopurinol-Induced Severe Cutaneous Adverse Reactions during Disease Onset Period: A Multicenter Retrospective Case-Control Clinical Study in Han Chinese.,2017,10.3389/fphar.2017.00923,https://pubmed.ncbi.nlm.nih.gov/29387007/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,31059844,Challenges in the treatment of Rheumatoid Arthritis.,2019,10.1016/j.autrev.2019.05.007,https://pubmed.ncbi.nlm.nih.gov/31059844/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,21912425,A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.,2013,10.1038/tpj.2011.41,https://pubmed.ncbi.nlm.nih.gov/21912425/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,22277675,Development of a rapid and inexpensive assay for detecting a surrogate genetic polymorphism of HLA-B*58:01: a partially predictive but useful biomarker for allopurinol-related Stevens-Johnson syndrome/toxic epidermal necrolysis in Japanese.,2012,10.2133/dmpk.dmpk-11-nt-120,https://pubmed.ncbi.nlm.nih.gov/22277675/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,19115949,Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).,2009,10.1086/596067,https://pubmed.ncbi.nlm.nih.gov/19115949/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,24808988,Genome-wide SNP analysis of the Systemic Capillary Leak Syndrome (Clarkson disease).,2013,10.4161/rdis.27445,https://pubmed.ncbi.nlm.nih.gov/24808988/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,21949713,Genetics of sputum gene expression in chronic obstructive pulmonary disease.,2011,10.1371/journal.pone.0024395,https://pubmed.ncbi.nlm.nih.gov/21949713/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,24804170,An omnibus permutation test on ensembles of two-locus analyses can detect pure epistasis and genetic heterogeneity in genome-wide association studies.,2013,10.1186/2193-1801-2-230,https://pubmed.ncbi.nlm.nih.gov/24804170/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,21682861,Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving.,2011,10.1186/1471-2148-11-171,https://pubmed.ncbi.nlm.nih.gov/21682861/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,16642438,Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.,2006,10.1086/503821,https://pubmed.ncbi.nlm.nih.gov/16642438/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSORS1C1,ENSG00000204540,Unsafe,12930300,Polymorphisms in the SEEK1 and SPR1 genes on 6p21.3 associate with psoriasis in the Swedish population.,2003,10.1034/j.1600-0625.2003.00048.x,https://pubmed.ncbi.nlm.nih.gov/12930300/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,42633698,"RNF123 Inhibits the Proliferation, Migration, and Invasion of Thyroid Cancer by Inhibiting KAT5-Mediated PSPC1 Histone Acetylation.",2026,10.1002/mc.70168,https://pubmed.ncbi.nlm.nih.gov/42633698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,41986651,PSPC1-AS2/PSPC1 axis drives STAT3-dependent CCL2 expression to promote M2 macrophage polarization and liver metastasis in gastric cancer.,2026,10.1038/s41388-026-03785-x,https://pubmed.ncbi.nlm.nih.gov/41986651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,41243096,Regulation of the mechanoresponsive Neat1 and PSPC1 by substrate stiffness in TGF-β1-induced renal progenitor cell fate.,2025,10.1186/s12929-025-01196-w,https://pubmed.ncbi.nlm.nih.gov/41243096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,41345872,PSPC1-SMAD3 axis regulates iron-induced beiging of adipocytes in white adipose tissue.,2025,10.1186/s12964-025-02570-9,https://pubmed.ncbi.nlm.nih.gov/41345872/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,41023804,LncRNA CASC19 promotes pancreatic cancer progression by increasing PSPC1 protein stability and facilitating the oncogenic PSPC1/ β-Catenin pathway.,2025,10.1186/s10020-025-01363-7,https://pubmed.ncbi.nlm.nih.gov/41023804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,42206151,Timing-dependent responses of &lt;i&gt;Fusarium graminearum&lt;/i&gt; suppression and malting quality in barley following PSP1 elicitor application.,2026,10.3389/fpls.2026.1838206,https://pubmed.ncbi.nlm.nih.gov/42206151/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,40520856,Paraspeckle Component 1: a multifunctional RNA binding protein.,2025,10.62347/riwh3000,https://pubmed.ncbi.nlm.nih.gov/40520856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,40962170,"PSPC1 knockout promotes radiosensitivity, inhibits EMT, and metastasis of nasopharyngeal carcinoma cells.",2025,10.1016/j.yexcr.2025.114755,https://pubmed.ncbi.nlm.nih.gov/40962170/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,40352720,The NONO protein regulates nonclassical DNA structure: Effects on circadian genes and DNA damage.,2025,10.1016/j.isci.2025.112408,https://pubmed.ncbi.nlm.nih.gov/40352720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,39954676,PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1.,2025,10.1016/j.stem.2025.01.010,https://pubmed.ncbi.nlm.nih.gov/39954676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,40634299,M6A-METTL3-dependent nuclear PANC754/PSPC1/H3K4me1 repression complex regulate immune evasive LGALS7 signal to enhance immunotherapy against colorectal cancer.,2025,10.1038/s41419-025-07820-9,https://pubmed.ncbi.nlm.nih.gov/40634299/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,40959076,Liquid-liquid phase separation in gastric cancer: identifying novel biomarkers and therapeutic targets through gene signature analysis.,2025,10.3389/fimmu.2025.1620390,https://pubmed.ncbi.nlm.nih.gov/40959076/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,42002574,"Dietary Spirulina platensis phycocyanin enhances growth performance, antioxidant status, and immune-related gene expression in Japanese quails (Coturnix japonica).",2026,10.1038/s41598-026-45365-9,https://pubmed.ncbi.nlm.nih.gov/42002574/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,41630184,Development of PolyHis-Targeting PROTAC Degraders.,2026,10.1002/anie.202522845,https://pubmed.ncbi.nlm.nih.gov/41630184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,41492215,Integrative Bioinformatics Reveals Novel Molecular Mechanisms and Therapeutic Targets in Acute Myeloid Leukaemia.,2026,10.1111/jcmm.71007,https://pubmed.ncbi.nlm.nih.gov/41492215/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,40593584,"NONO, SFPQ, and PSPC1 promote telomerase recruitment to the telomere.",2025,10.1038/s41467-025-60924-w,https://pubmed.ncbi.nlm.nih.gov/40593584/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,40054451,PSPC1 bridges cancer stemness and malignancy in acute myeloid leukemia.,2025,10.1016/j.stem.2025.02.006,https://pubmed.ncbi.nlm.nih.gov/40054451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,42765842,Engineering a protein homodimer from a heterodimer: A chimeric DBHS protein.,2026,10.1002/pro.70799,https://pubmed.ncbi.nlm.nih.gov/42765842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,38551131,Role of RNA binding proteins of the Drosophila behavior and human splicing (DBHS) family in health and cancer.,2024,10.1080/15476286.2024.2332855,https://pubmed.ncbi.nlm.nih.gov/38551131/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,38793620,"PSPC1 Binds to HCV IRES and Prevents Ribosomal Protein S5 Binding, Inhibiting Viral RNA Translation.",2024,10.3390/v16050738,https://pubmed.ncbi.nlm.nih.gov/38793620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,38360141,SKP2 promotes the metastasis of pancreatic ductal adenocarcinoma by suppressing TRIM21-mediated PSPC1 degradation.,2024,10.1016/j.canlet.2024.216733,https://pubmed.ncbi.nlm.nih.gov/38360141/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,38069409,PSPC1 Inhibition Synergizes with Poly(ADP-ribose) Polymerase Inhibitors in a Preclinical Model of BRCA-Mutated Breast/Ovarian Cancer.,2023,10.3390/ijms242317086,https://pubmed.ncbi.nlm.nih.gov/38069409/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,38375428,"Sleep apnoea increases biomarkers of immune evasion, lymphangiogenesis and tumour cell aggressiveness in high-risk patients and those with established lung cancer.",2024,10.1183/23120541.00777-2023,https://pubmed.ncbi.nlm.nih.gov/38375428/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,36507075,Single-Cell Transcriptome Analysis Reveals Paraspeckles Expression in Osteosarcoma Tissues.,2022,10.1177/11769351221140101,https://pubmed.ncbi.nlm.nih.gov/36507075/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,34340703,PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression.,2021,10.1186/s12929-021-00753-3,https://pubmed.ncbi.nlm.nih.gov/34340703/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,36626244,Profiling of a novel circadian clock-related prognostic signature and its role in immune function and response to molecular targeted therapy in pancreatic cancer.,2023,10.18632/aging.204462,https://pubmed.ncbi.nlm.nih.gov/36626244/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,30087681,"Development of PSP1, a Biostimulant Based on the Elicitor AsES for Disease Management in Monocot and Dicot Crops.",2018,10.3389/fpls.2018.00844,https://pubmed.ncbi.nlm.nih.gov/30087681/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,38086945,Panel-based RNA fusion sequencing improves diagnostics of pediatric acute myeloid leukemia.,2024,10.1038/s41375-023-02102-9,https://pubmed.ncbi.nlm.nih.gov/38086945/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,39214388,The cellular paraspeckle component SFPQ associates with the viral processivity factor ORF59 during lytic replication of Kaposi's Sarcoma-associated herpesvirus (KSHV).,2024,10.1016/j.virusres.2024.199456,https://pubmed.ncbi.nlm.nih.gov/39214388/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,34948100,Neurofibromin Deficiency Causes Epidermal Growth Factor Receptor Upregulation through the Activation of Ras/ERK/SP1 Signaling Pathway in Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheet Tumor.,2021,10.3390/ijms222413308,https://pubmed.ncbi.nlm.nih.gov/34948100/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,29946326,Elicitor-Based Biostimulant PSP1 Protects Soybean Against Late Season Diseases in Field Trials.,2018,10.3389/fpls.2018.00763,https://pubmed.ncbi.nlm.nih.gov/29946326/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,34650978,Increased Nuclear Transporter Importin 7 Contributes to the Tumor Growth and Correlates With CD8 T Cell Infiltration in Cervical Cancer.,2021,10.3389/fcell.2021.732786,https://pubmed.ncbi.nlm.nih.gov/34650978/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,35134835,A fungal protease named AsES triggers antiviral immune responses and effectively restricts virus infection in arabidopsis and Nicotiana benthamiana plants.,2022,10.1093/aob/mcac013,https://pubmed.ncbi.nlm.nih.gov/35134835/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPC1,ENSG00000121390,Unsafe,11790299,Paraspeckles: a novel nuclear domain.,2002,10.1016/s0960-9822(01)00632-7,https://pubmed.ncbi.nlm.nih.gov/11790299/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,42651783,PSPH Promotes Hepatocellular Carcinoma Progression by Upregulating HIF-1α and Is Regulated by LncRNA GSEC/miR-101-3p.,2026,10.3390/cimb48080784,https://pubmed.ncbi.nlm.nih.gov/42651783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,42478894,Serine Ameliorates Cadmium-Induced Testicular Injury by Regulating the PGAM1/PHGDH Signaling Pathway.,2026,10.1002/jbt.71024,https://pubmed.ncbi.nlm.nih.gov/42478894/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,42552870,Evolution-guided yeast complementation reveals functional differences in human PSPH variants.,2026,10.1002/2211-5463.70308,https://pubmed.ncbi.nlm.nih.gov/42552870/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,42159130,PSPH and CXCL2 Predict Treatment Response in First-Episode Schizophrenia: a Retrospective Study.,2026,10.7754/clin.lab.2025.250683,https://pubmed.ncbi.nlm.nih.gov/42159130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,41904508,Research based on serine metabolism indicates mesenchymal stem cells alleviate psoriasis by regulating the PSPH-PINK1-Parkin-NLRP3 pathway in HaCaT.,2026,10.1186/s13287-026-04964-z,https://pubmed.ncbi.nlm.nih.gov/41904508/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,41702885,ΔNp63α drives serine synthesis to promote carboplatin resistance in NSCLC.,2026,10.1038/s41419-026-08497-4,https://pubmed.ncbi.nlm.nih.gov/41702885/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,41333034,Multi-Omics Mendelian Randomization Identifies Therapeutic Targets for Sjögren's Disease with Clinical and Bayesian Validation.,2025,10.2147/jir.s543644,https://pubmed.ncbi.nlm.nih.gov/41333034/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,40371136,PSPH promotes the proliferation and metastasis of esophageal squamous cell carcinoma through MAPK signaling pathways.,2025,10.62347/ogmw9514,https://pubmed.ncbi.nlm.nih.gov/40371136/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,42764910,Quercetin's antitumor effect in bladder cancer: Synergistic regulation of gut microbiota and l-serine metabolic pathway.,2026,10.1016/j.apsb.2026.03.034,https://pubmed.ncbi.nlm.nih.gov/42764910/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,39537592,Sertraline/chloroquine combination therapy to target hypoxic and immunosuppressive serine/glycine synthesis-dependent glioblastomas.,2024,10.1038/s41389-024-00540-3,https://pubmed.ncbi.nlm.nih.gov/39537592/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,41836241,A systematic characterization of amino acid metabolism-related genes reveals molecular subtypes and a prognostic signature in bladder cancer.,2026,10.3389/fonc.2026.1754912,https://pubmed.ncbi.nlm.nih.gov/41836241/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,40684997,Targeting BACH1/PSPH axis suppresses bladder cancer progression and gemcitabine resistance by downregulating S100A2 expression.,2025,10.1016/j.bcp.2025.117182,https://pubmed.ncbi.nlm.nih.gov/40684997/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,41868751,AD diagnosis model based on fusion of heterogeneous brain imaging and genomic data.,2026,10.3389/fnins.2026.1719390,https://pubmed.ncbi.nlm.nih.gov/41868751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,40567072,PSPH promotes colorectal cancer growth by triggering autophagy through AMPK-ULK1 activation and enhancing tumor immune evasion.,2025,10.4149/gpb_2025019,https://pubmed.ncbi.nlm.nih.gov/40567072/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,40855366,NRF2-SOX4 complex regulates PSPH in hepatocellular carcinoma and modulates M2 macrophage differentiation.,2025,10.1038/s41417-025-00951-3,https://pubmed.ncbi.nlm.nih.gov/40855366/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,40598535,Protein post-translational modifications in serine synthetic pathway: functions and molecular mechanisms.,2025,10.1186/s12964-025-02327-4,https://pubmed.ncbi.nlm.nih.gov/40598535/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,42250625,YAP mediates activation of the serine synthesis pathway in the heart during pressure overload.,2026,10.1016/j.yjmcc.2026.06.002,https://pubmed.ncbi.nlm.nih.gov/42250625/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,42913161,Integrative computational analysis of urinary PAH biomarkers and Parkinson's disease-related molecular signatures.,2026,10.1016/j.compbiolchem.2026.109494,https://pubmed.ncbi.nlm.nih.gov/42913161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,41765937,LIS1 mediated Schwann cell reprogramming enhances perineural invasion by activating the serine/NMDAR/AKT signaling pathway in head and neck squamous carcinoma.,2026,10.1186/s12935-026-04243-0,https://pubmed.ncbi.nlm.nih.gov/41765937/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,42023217,Single cell transcriptomics reveals dendritic cell subsets in bovine afferent lymph and immune cell-resolved responses to BCG vaccination.,2026,10.3389/fimmu.2026.1764014,https://pubmed.ncbi.nlm.nih.gov/42023217/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,39735553,Multi-omics analysis-based clinical and functional significance of a novel prognostic and immunotherapeutic gene signature derived from amino acid metabolism pathways in lung adenocarcinoma.,2024,10.3389/fimmu.2024.1361992,https://pubmed.ncbi.nlm.nih.gov/39735553/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,36849198,Downregulation of phosphoserine phosphatase potentiates tumor immune environments to enhance immune checkpoint blockade therapy.,2023,10.1136/jitc-2022-005986,https://pubmed.ncbi.nlm.nih.gov/36849198/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,36092735,Phosphoserine phosphatase as an indicator for survival through potentially influencing the infiltration levels of immune cells in neuroblastoma.,2022,10.3389/fcell.2022.873710,https://pubmed.ncbi.nlm.nih.gov/36092735/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,41352195,Maintaining albumen quality and reducing feed costs in laying hens through glycine and serine supplementation in low-protein diets.,2026,10.1016/j.psj.2025.106100,https://pubmed.ncbi.nlm.nih.gov/41352195/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,38945230,The hidden threat: Comprehensive assessment of antibiotic and disinfectant resistance in commercial pig slaughterhouses.,2024,10.1016/j.scitotenv.2024.174222,https://pubmed.ncbi.nlm.nih.gov/38945230/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,36157801,Computed tomography combined with gastroscopy for assessment of pancreatic segmental portal hypertension.,2022,10.12998/wjcc.v10.i24.8568,https://pubmed.ncbi.nlm.nih.gov/36157801/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,34979926,Phosphoserine phosphatase as a prognostic biomarker in patients with gastric cancer and its potential association with immune cells.,2022,10.1186/s12876-021-02073-0,https://pubmed.ncbi.nlm.nih.gov/34979926/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSPH,ENSG00000146733,Unsafe,39773485,FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restriction.,2025,10.1186/s12964-024-02016-8,https://pubmed.ncbi.nlm.nih.gov/39773485/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,39794890,PSTK exerts protective role in cisplatin-tubular cell injury via BAX/BCL2/Caspase3 pathway.,2025,10.14814/phy2.70162,https://pubmed.ncbi.nlm.nih.gov/39794890/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,39912669,"PSTK inhibition activates cGAS-STING, precipitating ferroptotic cell death in leukemic stem cells.",2025,10.1182/blood.2024026040,https://pubmed.ncbi.nlm.nih.gov/39912669/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,40913320,Chromosomal Abnormalities in Couples Experiencing Recurrent Implantation Failure in West of Iran: A Case-Control Study.,2025,10.1002/mgg3.70137,https://pubmed.ncbi.nlm.nih.gov/40913320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,40289393,Retrospective clinical and molecular characterisation of patients with penile intraepithelial neoplasia.,2025,10.1111/bju.16754,https://pubmed.ncbi.nlm.nih.gov/40289393/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,40226916,tRNA binding to Kti12 is crucial for wobble uridine modification by Elongator.,2025,10.1093/nar/gkaf296,https://pubmed.ncbi.nlm.nih.gov/40226916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,34983546,CRISPR screens uncover protective effect of PSTK as a regulator of chemotherapy-induced ferroptosis in hepatocellular carcinoma.,2022,10.1186/s12943-021-01466-9,https://pubmed.ncbi.nlm.nih.gov/34983546/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,32298370,Proteomic analysis of infected primary human leucocytes revealed PSTK as potential treatment-monitoring marker for active and latent tuberculosis.,2020,10.1371/journal.pone.0231834,https://pubmed.ncbi.nlm.nih.gov/32298370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,40235466,Survey of Structural Autosomal Abnormalities and Autosomal Variants in Infertile Patients Treated at Some IVF Centers in Vietnam.,2025,10.2147/tacg.s510933,https://pubmed.ncbi.nlm.nih.gov/40235466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,28419530,Differential expression profile analysis of PSTK-regulated mRNAs in podocytes.,2019,10.1002/jcb.26076,https://pubmed.ncbi.nlm.nih.gov/28419530/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,38678230,Diverse impacts of female chromosomal polymorphisms on assisted reproduction outcomes: a retrospective cohort study.,2024,10.1186/s12884-024-06532-w,https://pubmed.ncbi.nlm.nih.gov/38678230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,34021786,Proximal junctional kyphosis is a rebalancing spinal phenomenon due to insufficient postoperative thoracic kyphosis after adolescent idiopathic scoliosis surgery.,2021,10.1007/s00586-021-06875-4,https://pubmed.ncbi.nlm.nih.gov/34021786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,36679036,"History, Phylogeny, Biodiversity, and New Computer-Based Tools for Efficient Micropropagation and Conservation of Pistachio (Pistacia spp.) Germplasm.",2023,10.3390/plants12020323,https://pubmed.ncbi.nlm.nih.gov/36679036/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,34885702,Mechanisms Affecting the Biosynthesis and Incorporation Rate of Selenocysteine.,2021,10.3390/molecules26237120,https://pubmed.ncbi.nlm.nih.gov/34885702/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,33017394,"Trypanosomatid selenophosphate synthetase structure, function and interaction with selenocysteine lyase.",2020,10.1371/journal.pntd.0008091,https://pubmed.ncbi.nlm.nih.gov/33017394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,33224150,Hepatic-Specific Decrease in the Expression of Selenoenzymes and Factors Essential for Selenium Processing After Endotoxemia.,2020,10.3389/fimmu.2020.595282,https://pubmed.ncbi.nlm.nih.gov/33224150/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,34982279,Practice patterns regarding regional corticosteroid treatment in noninfectious Uveitis: a survey study.,2022,10.1186/s12348-021-00281-z,https://pubmed.ncbi.nlm.nih.gov/34982279/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,30916349,"Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator.",2019,10.1093/nar/gkz190,https://pubmed.ncbi.nlm.nih.gov/30916349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,25592138,PSTK is a novel gene associated with early lung injury in Paraquat Poisoning.,2015,10.1016/j.lfs.2014.12.023,https://pubmed.ncbi.nlm.nih.gov/25592138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,26586914,Leishmania donovani Encodes a Functional Selenocysteinyl-tRNA Synthase.,2016,10.1074/jbc.m115.695007,https://pubmed.ncbi.nlm.nih.gov/26586914/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,33311907,Clinical Manifestations of Chromosomal Anomalies and Polymorphic Variations in Patients Suffering from Reproductive Failure.,2020,10.4103/jhrs.jhrs_46_19,https://pubmed.ncbi.nlm.nih.gov/33311907/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,30815697,Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity.,2019,10.1093/toxsci/kfz024,https://pubmed.ncbi.nlm.nih.gov/30815697/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,31940721,Whole Genome Analysis of the Red-Crowned Crane Provides Insight into Avian Longevity.,2020,10.14348/molcells.2019.0190,https://pubmed.ncbi.nlm.nih.gov/31940721/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,19142586,An engineered Bacillus thuringiensis strain with insecticidal activity against Scarabaeidae (Anomala corpulenta) and Chrysomelidae (Leptinotarsa decemlineata and Colaphellus bowringi).,2009,10.1007/s10529-009-9913-8,https://pubmed.ncbi.nlm.nih.gov/19142586/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PSTK,ENSG00000179988,Unsafe,16572346,Engineered Bacillus thuringiensis GO33A with broad insecticidal activity against lepidopteran and coleopteran pests.,2006,10.1007/s00253-006-0390-x,https://pubmed.ncbi.nlm.nih.gov/16572346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,41555757,Isoform-Specific Splicing of ANK2 by PTBP2 Orchestrates Retinal Pigment Epithelial-to-Neuron Fate Conversion.,2026,10.1111/jnc.70358,https://pubmed.ncbi.nlm.nih.gov/41555757/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,41615539,Ptbp2 Alleviates Neuroinflammation and Blood-brain Barrier Disruption via Modulating Microglial Polarization in Ischemic Stroke.,2026,10.1007/s12035-026-05704-3,https://pubmed.ncbi.nlm.nih.gov/41615539/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,42255218,"Transcription factor SOX4 promotes proliferation, invasion and lymphatic metastasis of laryngeal squamous cell carcinoma via PTBP2 activation.",2026,10.3389/fonc.2026.1829851,https://pubmed.ncbi.nlm.nih.gov/42255218/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,41667423,DNA polymerase kappa stabilized by Ptbp2 interacts with MRE11 and promotes genomic instability in leukemia.,2026,10.1038/s41420-026-02951-0,https://pubmed.ncbi.nlm.nih.gov/41667423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,41387900,A single-cell atlas of RNA alternative splicing in the glioma-immune ecosystem.,2025,10.1186/s13059-025-03889-9,https://pubmed.ncbi.nlm.nih.gov/41387900/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,40220253,Analysis and identification of PTBP2 as an oncogene in hepatocellular carcinoma.,2025,10.1007/s12672-025-02216-9,https://pubmed.ncbi.nlm.nih.gov/40220253/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,42293486,Nasopharyngeal tuberculosis mimicking malignancy on MRI: A rare clinical entity in an immunocompetent adult.,2026,10.1016/j.radcr.2026.04.088,https://pubmed.ncbi.nlm.nih.gov/42293486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,40113750,PTBP2 promotes cell survival and autophagy in chronic myeloid leukemia by stabilizing BNIP3.,2025,10.1038/s41419-025-07529-9,https://pubmed.ncbi.nlm.nih.gov/40113750/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,42140427,Nuclear Proteome Map of Mouse Heart Chambers.,2026,10.1016/j.mcpro.2026.101585,https://pubmed.ncbi.nlm.nih.gov/42140427/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,40465779,Polypyrimidine tract binding proteins PTBP1 and PTBP2 associate with distinct proteins and have distinct post-translational modifications in neuronal nuclear extract.,2025,10.1371/journal.pone.0325143,https://pubmed.ncbi.nlm.nih.gov/40465779/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,38597390,KIS counteracts PTBP2 and regulates alternative exon usage in neurons.,2024,10.7554/elife.96048,https://pubmed.ncbi.nlm.nih.gov/38597390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,37832540,PTBP2 attenuation facilitates fibroblast to neuron conversion by promoting alternative splicing of neuronal genes.,2023,10.1016/j.stemcr.2023.09.012,https://pubmed.ncbi.nlm.nih.gov/37832540/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,37858745,"PTBP2 binds to a testis-specific long noncoding RNA, Tesra, and activates transcription of the Prss42/Tessp-2 gene.",2024,10.1016/j.gene.2023.147907,https://pubmed.ncbi.nlm.nih.gov/37858745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,41341622,Identifying key regulators in neuronal transdifferentiation by gene regulatory network analysis.,2025,10.1093/pnasnexus/pgaf365,https://pubmed.ncbi.nlm.nih.gov/41341622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,38336291,Unstructured linker regions play a role in the differential splicing activities of paralogous RNA binding proteins PTBP1 and PTBP2.,2024,10.1016/j.jbc.2024.105733,https://pubmed.ncbi.nlm.nih.gov/38336291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,37149717,Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching.,2023,10.1038/s41467-023-38273-3,https://pubmed.ncbi.nlm.nih.gov/37149717/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,39246602,Ptbp2 re-expression rescues axon growth defects in Smn-deficient motoneurons.,2024,10.3389/fnmol.2024.1393779,https://pubmed.ncbi.nlm.nih.gov/39246602/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,37438340,Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr.,2023,10.1038/s41467-023-39787-6,https://pubmed.ncbi.nlm.nih.gov/37438340/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,39325292,Construction of an Aspergillus oryzae △nptB△pyrG Host for Homologous Expression of Lipase and Catalytic Property Characterization of Recombinant Lipase.,2025,10.1007/s12010-024-05064-5,https://pubmed.ncbi.nlm.nih.gov/39325292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,40766308,Five autoantibodies identified from immune complexes as breast cancer biomarkers.,2025,10.3389/fimmu.2025.1640054,https://pubmed.ncbi.nlm.nih.gov/40766308/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,37040518,PTBP2-Mediated Alternative Splicing of IRF9 Controls Tumor-Associated Monocyte/Macrophage Chemotaxis and Repolarization in Neuroblastoma Progression.,2023,10.34133/research.0033,https://pubmed.ncbi.nlm.nih.gov/37040518/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,36203873,PTBPs: An immunomodulatory-related prognostic biomarker in pan-cancer.,2022,10.3389/fmolb.2022.968458,https://pubmed.ncbi.nlm.nih.gov/36203873/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,37077246,Development of a new cellular immunological detection method for tuberculosis based on HupB protein induced IL-6 release test.,2023,10.3389/fmicb.2023.1148503,https://pubmed.ncbi.nlm.nih.gov/37077246/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,33452356,A quantitative model of cellular decision making in direct neuronal reprogramming.,2021,10.1038/s41598-021-81089-8,https://pubmed.ncbi.nlm.nih.gov/33452356/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,32081131,Polypyrimidine tract-binding proteins are essential for B cell development.,2020,10.7554/elife.53557,https://pubmed.ncbi.nlm.nih.gov/32081131/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,35440129,"Multilayered regulations of alternative splicing, NMD, and protein stability control temporal induction and tissue-specific expression of TRIM46 during axon formation.",2022,10.1038/s41467-022-29786-4,https://pubmed.ncbi.nlm.nih.gov/35440129/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,34459124,LncRNA nuclear-enriched abundant transcript 1 shuttled by prostate cancer cells-secreted exosomes initiates osteoblastic phenotypes in the bone metastatic microenvironment via miR-205-5p/runt-related transcription factor 2/splicing factor proline- and glutamine-rich/polypyrimidine tract-binding protein 2 axis.,2021,10.1002/ctm2.493,https://pubmed.ncbi.nlm.nih.gov/34459124/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,30504735,Effect of premature birth on long-term systolic blood pressure variability in women.,2018,10.14744/anatoljcardiol.2018.97415,https://pubmed.ncbi.nlm.nih.gov/30504735/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,27926877,PTBP1 and PTBP2 Serve Both Specific and Redundant Functions in Neuronal Pre-mRNA Splicing.,2016,10.1016/j.celrep.2016.11.034,https://pubmed.ncbi.nlm.nih.gov/27926877/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,34184986,5'-UTR SNP of FGF13 causes translational defect and intellectual disability.,2021,10.7554/elife.63021,https://pubmed.ncbi.nlm.nih.gov/34184986/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,29581412,HnRNP L represses cryptic exons.,2018,10.1261/rna.065508.117,https://pubmed.ncbi.nlm.nih.gov/29581412/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,25187368,Inflammation and hyperglycemia mediate Deaf1 splicing in the pancreatic lymph nodes via distinct pathways during type 1 diabetes.,2015,10.2337/db14-0803,https://pubmed.ncbi.nlm.nih.gov/25187368/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,12213192,Alternative splicing of brain-specific PTB defines a tissue-specific isoform pattern that predicts distinct functional roles.,2002,10.1006/geno.2002.6826,https://pubmed.ncbi.nlm.nih.gov/12213192/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTBP2,ENSG00000117569,Unsafe,11003644,Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein.,2000,10.1128/mcb.20.20.7463-7479.2000,https://pubmed.ncbi.nlm.nih.gov/11003644/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,41857757,RAC1 regulates Sonic Hedgehog-medulloblastoma growth via GLI-mediated transcription.,2026,10.1093/neuonc/noag057,https://pubmed.ncbi.nlm.nih.gov/41857757/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,42371991,Desert Hedgehog mediates stem Leydig cell differentiation through Ptch2/Gli1/Sf1 signaling axis.,2026,10.7554/elife.109979,https://pubmed.ncbi.nlm.nih.gov/42371991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,42001685,Inhibition of PTCH1 drug efflux activity enhances chemotherapy efficacy against triple negative breast cancers.,2026,10.1016/j.tranon.2026.102777,https://pubmed.ncbi.nlm.nih.gov/42001685/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,42485885,"Hsa-mir-1293/GLI1/PTCH1 axis is involved in proliferation, migration, and EMT of laryngeal cancer.",2026,10.1016/j.bjorl.2026.101860,https://pubmed.ncbi.nlm.nih.gov/42485885/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,41888819,Challenging interpretation of low-level PTCH1 mosaicism in patients with clinically diagnosed Gorlin syndrome: a case series and review of the literature.,2026,10.1186/s13053-026-00332-3,https://pubmed.ncbi.nlm.nih.gov/41888819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,41748949,Partial truncation of the C-terminal domain of PTCH1 in cancer promotes tumourigenesis by non-canonical activation of a GLI-PI3K loop.,2026,10.1038/s41388-026-03698-9,https://pubmed.ncbi.nlm.nih.gov/41748949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,42650114,Age-Stratified Transcriptomic Profiling Identifies CEMIP as a Candidate Biomarker in Early-Onset Colorectal Cancer and Reveals an Association with PTCH1-Related Hedgehog Signaling.,2026,10.3390/genes17080922,https://pubmed.ncbi.nlm.nih.gov/42650114/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,41353440,CSNK1D inhibition suppresses head and neck squamous cell carcinoma progression through SHH and PTCH1 pathway.,2025,10.1038/s41419-025-08276-7,https://pubmed.ncbi.nlm.nih.gov/41353440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,41956745,[PTCH1 promotes epithelial mesenchymal transition and epithelial cell proliferation in the pathogenesis of chronic sinusitis with nasal polyps].,2026,10.3760/cma.j.cn112151-20250905-00594,https://pubmed.ncbi.nlm.nih.gov/41956745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,42204835,Distinction of dental mesenchymal cell populations during molar tooth germ development via analysis of the spatiotemporal expression patterns of mRNAs for Shh ligand receptors Ptch1 and Hip1 using in situ hybridization.,2026,10.1002/dvdy.70154,https://pubmed.ncbi.nlm.nih.gov/42204835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,42117983,Brain-Targeted Delivery of Phenformin Using Phospholipid and Non-Phospholipid Vesicles for SHH Medulloblastoma.,2026,10.3390/nano16090566,https://pubmed.ncbi.nlm.nih.gov/42117983/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,42712018,Role of PTCH1 receptor polymorphisms in the SHH signalling pathway as determinants of COPD severity and functional impairment.,2026,10.1080/08958378.2026.2728395,https://pubmed.ncbi.nlm.nih.gov/42712018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,40794264,NCOA4 inhibits glioma progression by suppressing the Sonic Hedgehog pathway and its overexpression indicates a better glioma prognosis.,2025,10.1007/s13258-025-01666-3,https://pubmed.ncbi.nlm.nih.gov/40794264/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,42840129,Case Report: High TMB fails to predict immunotherapy response in &lt;i&gt;PTCH1&lt;/i&gt;-mutant basal cell carcinoma with squamous differentiation.,2026,10.3389/fimmu.2026.1814345,https://pubmed.ncbi.nlm.nih.gov/42840129/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,42667406,"Molecular insights into uterine fibroids: crosstalk between SHH and Wnt pathways, DNA methylation, and miRNAs regulation.",2026,10.1007/s00438-026-02491-3,https://pubmed.ncbi.nlm.nih.gov/42667406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,40156412,Increased expression of PTCH1 and GLI1 in Bangladeshi TNBC Patients after Treatment with Doxorubicin and Cyclophosphamide Suggests a Favorable Response to Chemotherapy.,2025,10.31557/apjcp.2025.26.3.949,https://pubmed.ncbi.nlm.nih.gov/40156412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,42653652,Jiawei Qi Gong Wan Improves Endometrial Receptivity in PCOS-like Mice by Attenuating Inflammation: A Multi-Omics Study Linking Gut Microbiota and Metabolite Profiles.,2026,10.3390/ph19081153,https://pubmed.ncbi.nlm.nih.gov/42653652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,42707049,"Molecular profiling of pediatric medulloblastoma in Kazakhstan: Genomic alterations, subgroup distribution, and survival.",2026,10.1111/bpa.70144,https://pubmed.ncbi.nlm.nih.gov/42707049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,42018362,Causal Associations Between Immune Cell-Specific Gene Expression and Major Depressive Disorder: A Single-Cell Transcriptome-Wide Mendelian Randomization Study.,2026,10.1096/fj.202504837r,https://pubmed.ncbi.nlm.nih.gov/42018362/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,42372362,Multi-omics characterization of radiation-induced cerebellar remodeling and tumorigenic transcriptional programs.,2026,10.1016/j.neo.2026.101333,https://pubmed.ncbi.nlm.nih.gov/42372362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,41816662,Case Report: PTCH1 splice-site mutation and sonidegib treatment in Gorlin-Goltz syndrome: clinical insights from a family case study.,2026,10.3389/fmed.2026.1778460,https://pubmed.ncbi.nlm.nih.gov/41816662/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,41066729,Phase II Study of Vismodegib in Patients With &lt;i&gt;SMO-&lt;/i&gt; or &lt;i&gt;PTCH1&lt;/i&gt;-Mutated Tumors: Results From the National Cancer Institute Molecular Analysis for Therapy Choice Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Trial (EAY131) Subprotocol T.,2025,10.1200/po-25-00119,https://pubmed.ncbi.nlm.nih.gov/41066729/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,41191842,"Pertuzumab/Docetaxel/Carboplatin/Trastuzumab Regimen in Human Epidermal Growth Factor Receptor 2-Positive Early, Locally Advanced, and Oligometastatic Breast Cancer: Real-World Outcomes From India.",2025,10.1200/go-25-00273,https://pubmed.ncbi.nlm.nih.gov/41191842/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,41596411,Aberrant Activation of the Hedgehog Pathway in Cutaneous Melanoma: Therapeutic Potential of Pharmacological Inhibitors.,2026,10.3390/ijms27020762,https://pubmed.ncbi.nlm.nih.gov/41596411/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,42733821,An immunocompetent transplantable mouse model of basal cell carcinoma.,2026,10.1016/j.xjidi.2026.100525,https://pubmed.ncbi.nlm.nih.gov/42733821/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,41549283,TRV130 inhibits colon cancer progression via suppressing the Hedgehog signaling pathway: in vitro and in vivo evidence.,2026,10.1186/s41065-026-00633-6,https://pubmed.ncbi.nlm.nih.gov/41549283/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,41240053,Does Basal Cell Carcinoma Arise from a Precursor Lesion?,2026,10.1016/j.jid.2025.09.381,https://pubmed.ncbi.nlm.nih.gov/41240053/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,41620393,Sonic Hedgehog Pathway Modulation in Medulloblastoma: Focus on Vismodegib (GDC-0449).,2026,10.1002/dneu.70009,https://pubmed.ncbi.nlm.nih.gov/41620393/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,41487007,Identification of Senescence- and Inflammation-Related Genes and Immune Microenvironment Characterization in Intracranial Aneurysms,2026,10.2174/0118715303420035251023051847,https://pubmed.ncbi.nlm.nih.gov/41487007/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,40888643,MYB Activates the Hedgehog Signaling Pathway to Repress Natural Killer Cytotoxicity in Cervical Cancer.,2025,10.1002/kjm2.70084,https://pubmed.ncbi.nlm.nih.gov/40888643/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,41609192,A Case Report of Promising Response to Combination Therapy With an Immune Checkpoint Inhibitor (Pembrolizumab) and Multi-Targeted Tyrosine Kinase Inhibitor (Pazopanib) in Metastatic De-Differentiated Chondrosarcoma.,2026,10.1002/cnr2.70426,https://pubmed.ncbi.nlm.nih.gov/41609192/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,40674752,PTCH1::GLI1 Fusion Tumors of the Ovary: A Clinicopathologic Study of 3 Cases.,2025,10.1097/pgp.0000000000001110,https://pubmed.ncbi.nlm.nih.gov/40674752/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,41254728,Strategic competencies for telemedicine physicians: insights from a qualitative study on doctor-to-doctor healthcare delivery in India.,2025,10.1186/s12913-025-13564-1,https://pubmed.ncbi.nlm.nih.gov/41254728/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,38310539,PTCH1 mutation as a potential predictive biomarker for immune checkpoint inhibitors in gastrointestinal cancer.,2024,10.1093/carcin/bgae007,https://pubmed.ncbi.nlm.nih.gov/38310539/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTCH1,ENSG00000185920,Unsafe,8647801,A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities.,1996,10.1074/jbc.271.21.12125,https://pubmed.ncbi.nlm.nih.gov/8647801/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,42025358,Simply complex - the structure of the cerebellar neuronal lineage.,2026,10.1016/bs.ctdb.2026.01.012,https://pubmed.ncbi.nlm.nih.gov/42025358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,41198649,Acinar-specific loss of activating transcription factor 3 restricts KRAS&lt;sup&gt;G12D&lt;/sup&gt; mediated transcriptional changes and PanIN progression.,2025,10.1038/s41420-025-02777-2,https://pubmed.ncbi.nlm.nih.gov/41198649/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,40721003,PRDM13 is required for specification of PAX2 lineage inhibitory neurons in the developing cerebellum.,2025,10.1016/j.ydbio.2025.07.012,https://pubmed.ncbi.nlm.nih.gov/40721003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,41429223,ADAM17-dependent Autocrine and Paracrine Signaling Promotes Pancreatic Premalignant Progression.,2026,10.1016/j.jcmgh.2025.101711,https://pubmed.ncbi.nlm.nih.gov/41429223/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,40853902,Preclinical Fluorescence-Guided Imaging Leveraging Surrounding Sentinel Tumor Microenvironment Identifies High-Risk Premalignant Pancreatic Lesions.,2025,10.1158/1078-0432.ccr-25-1092,https://pubmed.ncbi.nlm.nih.gov/40853902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,40443916,A Rare &lt;i&gt;PTF1A&lt;/i&gt; Enhancer Mutation Causing Neonatal Diabetes Mellitus with Pancreatic Agenesis: Case Report and Considerations for Genetic Evaluation.,2025,10.5812/ijem-158056,https://pubmed.ncbi.nlm.nih.gov/40443916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,42480541,Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis.,2026,10.1016/j.devcel.2026.06.016,https://pubmed.ncbi.nlm.nih.gov/42480541/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,41665992,Spatiotemporal histogenesis of the developing human cerebellum reveals dynamic layering of Bergmann glia.,2026,10.1073/pnas.2525673123,https://pubmed.ncbi.nlm.nih.gov/41665992/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,42166442,Molecular and structural reprogramming of gastric cancer revealed by systems-level transcriptomic analysis.,2026,10.1371/journal.pone.0344143,https://pubmed.ncbi.nlm.nih.gov/42166442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,41530855,Immunological and molecular insights into acinar-ductal metaplasia and atypical flat lesions as precursor lesions of pancreatic ductal adenocarcinoma.,2026,10.1186/s13046-026-03643-4,https://pubmed.ncbi.nlm.nih.gov/41530855/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,39537822,Multiscale 3D genome rewiring during PTF1A-mediated somatic cell reprogramming into neural stem cells.,2024,10.1038/s42003-024-07230-1,https://pubmed.ncbi.nlm.nih.gov/39537822/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,42379263,Differential vulnerability of cochlear nuclei to Lmx1 deficiency: abnormal patterning and implications for auditory circuitry.,2026,10.1016/j.neulet.2026.138669,https://pubmed.ncbi.nlm.nih.gov/42379263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,39547411,Mouse Models for Pancreatic Ductal Adenocarcinoma are Affected by the cre-driver Used to Promote KRAS&lt;sup&gt;G12D&lt;/sup&gt; Activation.,2025,10.1016/j.jcmgh.2024.101428,https://pubmed.ncbi.nlm.nih.gov/39547411/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,42294485,Assessing vocal changes through spectral analyses of vocalizations in a cerebellar-specific dystonia mouse model.,2026,10.3389/dyst.2026.15530,https://pubmed.ncbi.nlm.nih.gov/42294485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,41553309,ENPP1-Regulated Extracellular Purine Metabolism Drives Pancreatitis-Mediated Pancreatic Cancer.,2026,10.1053/j.gastro.2025.09.032,https://pubmed.ncbi.nlm.nih.gov/41553309/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,42646511,Single-Dose L-Lysine-Induced Pancreatitis Followed by Pancreatic Neoplastic Progression in Adult &lt;i&gt;Kras/Trp53&lt;/i&gt;-Driven Mice.,2026,10.3390/mps9040116,https://pubmed.ncbi.nlm.nih.gov/42646511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,40812683,CREB Drives Acinar to Ductal Cells Reprogramming and Promotes Pancreatic Cancer Progression in Preclinical Models of Alcoholic Pancreatitis.,2025,10.1016/j.jcmgh.2025.101606,https://pubmed.ncbi.nlm.nih.gov/40812683/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,41419303,Hereditary chronic pancreatitis induced plasticity cooperates with mutant Kras in early pancreatic carcinogenesis.,2026,10.1136/gutjnl-2025-335947,https://pubmed.ncbi.nlm.nih.gov/41419303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,38967770,Pancreatic Differentiation of Oral Minor Salivary Gland Stem Cells.,2024,10.1007/s12015-024-10757-9,https://pubmed.ncbi.nlm.nih.gov/38967770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,41136544,Enhancing the diagnostic yield of monogenic diabetes in unresolved cases with early-onset hyperglycemia.,2025,10.1038/s43856-025-01031-1,https://pubmed.ncbi.nlm.nih.gov/41136544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,39824529,Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines.,2025,10.1136/jitc-2024-010579,https://pubmed.ncbi.nlm.nih.gov/39824529/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,41525104,Ablation of tumor-derived IGFBP-3 attenuates cancer-associated skeletal muscle wasting in murine pancreatic cancer.,2026,10.1152/ajpcell.00421.2025,https://pubmed.ncbi.nlm.nih.gov/41525104/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,35948109,Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features to Overcome Immunotherapy Resistance in Pancreatic Cancer.,2022,10.1053/j.gastro.2022.07.076,https://pubmed.ncbi.nlm.nih.gov/35948109/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,39048609,Activation of STING in pancreatic cancer-associated fibroblasts exerts an antitumor effect by enhancing tumor immunity.,2024,10.1038/s41598-024-68061-y,https://pubmed.ncbi.nlm.nih.gov/39048609/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,40175689,Overexpression of Tn antigen induces chronic pancreatitis in mice.,2025,10.1038/s41598-025-96060-0,https://pubmed.ncbi.nlm.nih.gov/40175689/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,34973294,Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma.,2022,10.1053/j.gastro.2021.12.273,https://pubmed.ncbi.nlm.nih.gov/34973294/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,40156144,Developmental perfluorooctanesulfonic acid exposure impairs exocrine pancreas function in zebrafish (Danio rerio).,2025,10.1093/toxsci/kfaf041,https://pubmed.ncbi.nlm.nih.gov/40156144/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,35316682,Dynamic profiling of immune microenvironment during pancreatic cancer development suggests early intervention and combination strategy of immunotherapy.,2022,10.1016/j.ebiom.2022.103958,https://pubmed.ncbi.nlm.nih.gov/35316682/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,36960404,Quantification of Behavioral Deficits in Developing Mice With Dystonic Behaviors.,2022,10.3389/dyst.2022.10494,https://pubmed.ncbi.nlm.nih.gov/36960404/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,36621763,Islet amyloid polypeptide does not suppress pancreatic cancer.,2023,10.1016/j.molmet.2023.101667,https://pubmed.ncbi.nlm.nih.gov/36621763/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,38955401,Pancreatic STAT5 activation promotes Kras&lt;sup&gt;G12D&lt;/sup&gt;-induced and inflammation-induced acinar-to-ductal metaplasia and pancreatic cancer.,2024,10.1136/gutjnl-2024-332225,https://pubmed.ncbi.nlm.nih.gov/38955401/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,36470842,Tris(4-chlorophenyl)methane and tris(4-chlorophenyl)methanol disrupt pancreatic organogenesis and gene expression in zebrafish embryos.,2023,10.1002/bdr2.2132,https://pubmed.ncbi.nlm.nih.gov/36470842/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,31694706,Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer.,2019,10.1186/s40425-019-0778-7,https://pubmed.ncbi.nlm.nih.gov/31694706/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,36107485,Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study.,2022,10.7554/elife.78921,https://pubmed.ncbi.nlm.nih.gov/36107485/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,34948416,Fucoxanthin Prevents Pancreatic Tumorigenesis in C57BL/6J Mice That Received Allogenic and Orthotopic Transplants of Cancer Cells.,2021,10.3390/ijms222413620,https://pubmed.ncbi.nlm.nih.gov/34948416/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,31526907,Loss of Pancreatic E-Cadherin Causes Pancreatitis-Like Changes and Contributes to Carcinogenesis.,2020,10.1016/j.jcmgh.2019.09.001,https://pubmed.ncbi.nlm.nih.gov/31526907/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTF1A,ENSG00000168267,Unsafe,10768861,Role of the basic helix-loop-helix transcription factor p48 in the differentiation phenotype of exocrine pancreas cancer cells.,2000,,https://pubmed.ncbi.nlm.nih.gov/10768861/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,41611798,Heritable pulmonary arterial hypertension: new genetic findings and environmental triggers.,2026,10.1038/s41598-025-34167-0,https://pubmed.ncbi.nlm.nih.gov/41611798/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,42214138,Cross-population meta-analysis and colocalisation analysis reveal novel and pleiotropic genes associated with rib and teat number in pigs.,2026,10.1016/j.animal.2026.101836,https://pubmed.ncbi.nlm.nih.gov/42214138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,40119175,Identification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesity.,2025,10.1038/s44321-025-00216-4,https://pubmed.ncbi.nlm.nih.gov/40119175/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,40683967,Genome-wide CRISPR/Cas9 screening identifies PTGR2 as a potential therapeutic target for sunitinib resistance in clear cell renal cell carcinoma.,2025,10.1038/s41598-025-12192-3,https://pubmed.ncbi.nlm.nih.gov/40683967/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,41110483,The tryptophan metabolite indole 3-propionic acid alleviates lung ischemia-reperfusion injury via prostaglandin reductase 2 in male mice.,2025,10.1016/j.bcp.2025.117427,https://pubmed.ncbi.nlm.nih.gov/41110483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,41463911,Integrative Multi-Omics Analysis Unveils Candidate Genes and Functional Variants for Growth and Reproductive Traits in Duroc Pigs.,2025,10.3390/ani15243627,https://pubmed.ncbi.nlm.nih.gov/41463911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,40388646,Human PTGR2 Inactivation Alters Eicosanoid Metabolism and Cytokine Response of Inflammatory Macrophages.,2025,10.1021/acschembio.5c00231,https://pubmed.ncbi.nlm.nih.gov/40388646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,42327006,Long-term expandable auricular chondrocytes reveal a conserved nine-gene decline module underlying senescence-independent dedifferentiation.,2026,10.1016/j.reth.2026.101146,https://pubmed.ncbi.nlm.nih.gov/42327006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,42910613,Ajugol Improves Liver Fibrosis by Modulating Bile Acid and Arachidonic Acid Metabolism in Mice.,2026,10.1002/ptr.70488,https://pubmed.ncbi.nlm.nih.gov/42910613/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,39006949,A hot and cold tumor‑related prognostic signature for stage II colorectal cancer.,2024,10.3892/ol.2024.14552,https://pubmed.ncbi.nlm.nih.gov/39006949/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,41056823,"Genome-wide association study implicates possible causal genes for growth, fatness, and reproductive traits in pig.",2025,10.1016/j.animal.2025.101654,https://pubmed.ncbi.nlm.nih.gov/41056823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,34936126,Host-microbial interactions between PTGR2 and Bifidobacterium in the early life gut of atopic dermatitis children.,2022,10.1111/pai.13724,https://pubmed.ncbi.nlm.nih.gov/34936126/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,26820738,"Inhibition of Prostaglandin Reductase 2, a Putative Oncogene Overexpressed in Human Pancreatic Adenocarcinoma, Induces Oxidative Stress-Mediated Cell Death Involving xCT and CTH Gene Expressions through 15-Keto-PGE2.",2016,10.1371/journal.pone.0147390,https://pubmed.ncbi.nlm.nih.gov/26820738/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,33861519,Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2.,2021,10.1002/cbic.202000879,https://pubmed.ncbi.nlm.nih.gov/33861519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,31587654,Genome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke.,2019,10.1161/strokeaha.119.026593,https://pubmed.ncbi.nlm.nih.gov/31587654/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,29175486,Targeting the 15-keto-PGE2-PTGR2 axis modulates systemic inflammation and survival in experimental sepsis.,2018,10.1016/j.freeradbiomed.2017.11.016,https://pubmed.ncbi.nlm.nih.gov/29175486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,23349302,The monocytic population in chronic lymphocytic leukemia shows altered composition and deregulation of genes involved in phagocytosis and inflammation.,2013,10.3324/haematol.2012.073080,https://pubmed.ncbi.nlm.nih.gov/23349302/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,32234218,Identification and biochemical characterization of the glutathione reductase family from Populus trichocarpa.,2020,10.1016/j.plantsci.2020.110459,https://pubmed.ncbi.nlm.nih.gov/32234218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,30661024,Secondhand smoke alters arachidonic acid metabolism and inflammation in infants and children with cystic fibrosis.,2019,10.1136/thoraxjnl-2018-211845,https://pubmed.ncbi.nlm.nih.gov/30661024/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,22998775,Prostaglandin reductase 2 modulates ROS-mediated cell death and tumor transformation of gastric cancer cells and is associated with higher mortality in gastric cancer patients.,2012,10.1016/j.ajpath.2012.07.006,https://pubmed.ncbi.nlm.nih.gov/22998775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,42844364,Human prostaglandin reductases dearomatize and inactivate benzothiazinone antitubercular drugs.,2026,10.1038/s44321-026-00526-1,https://pubmed.ncbi.nlm.nih.gov/42844364/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,34741172,Positive effects of amphiregulin on human oocyte maturation and its molecular drivers in patients with polycystic ovary syndrome.,2021,10.1093/humrep/deab237,https://pubmed.ncbi.nlm.nih.gov/34741172/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTGR2,ENSG00000140043,Unsafe,15004468,Cloning and characterization of a novel splicing variant of the ZADH1 gene.,2003,10.1159/000076293,https://pubmed.ncbi.nlm.nih.gov/15004468/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,40379623,"PTPN11 in cartilage development, adult homeostasis, and diseases.",2025,10.1038/s41413-025-00425-0,https://pubmed.ncbi.nlm.nih.gov/40379623/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,42568796,Bilateral testicular infiltration as the initial presentation of NRAS-mutant juvenile myelomonocytic leukemia: rapid molecular remission following azacitidine and haploidentical stem cell transplantation.,2026,10.1016/j.lrr.2026.100601,https://pubmed.ncbi.nlm.nih.gov/42568796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,42827643,Microplastic exposure is associated with enhanced PI3K-Akt signaling in DSS-induced colitis: integrated bioinformatics analyses and &lt;i&gt;in vivo&lt;/i&gt; validation.,2026,10.3389/fphar.2026.1875549,https://pubmed.ncbi.nlm.nih.gov/42827643/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,42711118,An Allometric Approach to Fine-Mapping Subcortical Volume Alterations in RASopathies.,2026,10.1523/eneuro.0017-26.2026,https://pubmed.ncbi.nlm.nih.gov/42711118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,41729075,Characterization of the clonal hierarchy and immunophenotype of PTPN11 mutations in acute myeloid leukemia.,2026,10.1172/jci.insight.193779,https://pubmed.ncbi.nlm.nih.gov/41729075/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,42334870,Targeting GLP-1R and IL-17A suppresses obesity-induced leukemia in an oncogenic PTPN11 mutation-driven model.,2026,10.1172/jci202856,https://pubmed.ncbi.nlm.nih.gov/42334870/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,42475297,Identification of divergent PTPN11 mutations in canine histiocytic sarcomas reveals evidence of an independent clonal origin.,2026,10.1371/journal.pone.0345429,https://pubmed.ncbi.nlm.nih.gov/42475297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,42193013,Molecular Advances in Juvenile Myelomonocytic Leukemia and Associated RASopathy.,2026,10.3390/cancers18101655,https://pubmed.ncbi.nlm.nih.gov/42193013/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,41367010,Investigating the prognostic potential of PTPN11 gene in papillary thyroid carcinoma: A comprehensive study of bulk and single cell transcriptome.,2025,10.1097/md.0000000000046315,https://pubmed.ncbi.nlm.nih.gov/41367010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,41784910,PTPN11-related Noonan syndrome predisposes to multifocal low-grade CNS tumors harboring FGFR1 variants.,2026,10.1007/s11060-026-05478-7,https://pubmed.ncbi.nlm.nih.gov/41784910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,42179644,"Integration of Network Pharmacology, Molecular Docking, and Molecular Dynamics to Decipher the Multi-Target Mechanisms of Crocin I in Parkinson's Disease with In Vivo Validation.",2026,10.1021/acsomega.5c10445,https://pubmed.ncbi.nlm.nih.gov/42179644/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,42761506,Computational insights into synergistic mechanisms of PD-901 and 5-azacitidine targeting PTPN11 (SHP2) E76K mutation in juvenile myelomonocytic leukemia.,2026,10.3389/fbinf.2026.1887328,https://pubmed.ncbi.nlm.nih.gov/42761506/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,42890062,Immune and inflammatory features associated with pyroptosis- and myocardial fibrosis-related genes in HFpEF: a machine learning study.,2026,10.3389/fimmu.2026.1925067,https://pubmed.ncbi.nlm.nih.gov/42890062/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,42780125,Astilbin: a novel therapeutic strategy for bone destruction in rheumatoid arthritis.,2026,10.3389/fimmu.2026.1932692,https://pubmed.ncbi.nlm.nih.gov/42780125/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,41608989,Targeting MCL-1 and MAPK overcomes venetoclax resistance in FLT3-ITD-positive AML cells harbouring activating PTPN11 (SHP-2) mutations.,2026,10.1111/bjh.70344,https://pubmed.ncbi.nlm.nih.gov/41608989/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,41940405,"Targeted Clinical Analysis of PTPN11, SOS1, and NRAS Mutations and Associated Cardiac, Auditory, and Ophthalmologic Findings in Noonan Syndrome Patients.",2026,10.1159/000546683,https://pubmed.ncbi.nlm.nih.gov/41940405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,41786942,Clinical phenotypes and cochlear implant outcomes in patients with PTPN11-associated noonan spectrum disorders: Insights from a genetically screened cohort.,2026,10.1007/s00405-026-10056-8,https://pubmed.ncbi.nlm.nih.gov/41786942/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,42172315,Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variants.,2026,10.1126/sciadv.aea9389,https://pubmed.ncbi.nlm.nih.gov/42172315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,40748755,Innate immune mechanisms hijacked by leukemia-initiating stem cells for selective advantage and immune evasion in Ptpn11-associated JMML.,2025,10.1016/j.celrep.2025.116087,https://pubmed.ncbi.nlm.nih.gov/40748755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,40442926,Linear epidermal naevus associated with a novel mosaic heterozygous PTPN11 variant.,2025,10.1093/bjd/ljaf210,https://pubmed.ncbi.nlm.nih.gov/40442926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,41462587,SHP2: A Redox-Sensitive Regulator Linking Immune Checkpoint Inhibitor Therapy to Cancer Treatment and Vascular Risk.,2025,10.3390/antiox14121388,https://pubmed.ncbi.nlm.nih.gov/41462587/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,42906368,"Sex-specific accumulation and oxidative stress of tris(1,3-dichloro-2-propyl) phosphate and its metabolite bis(1,3-dichloro-2-propyl) phosphate in rats after 90-day exposure.",2026,10.1016/j.ecoenv.2026.120949,https://pubmed.ncbi.nlm.nih.gov/42906368/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,42233403,Therapeutic targeting of IL-17A-driven PTGS2/NLRP3 inflammasome activation in juvenile myelomonocytic leukemia.,2026,10.1182/blood.2025032588,https://pubmed.ncbi.nlm.nih.gov/42233403/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,41853813,Durable disease control in a radiation-induced high-grade glioma harboring &lt;i&gt;NF1&lt;/i&gt; and &lt;i&gt;PTPN11&lt;/i&gt; co-mutations.,2026,10.1093/noajnl/vdag053,https://pubmed.ncbi.nlm.nih.gov/41853813/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,41732886,Evaluation of plasticizer toxicity effects and mechanisms in gastric cancer based on network toxicology and molecular docking.,2026,10.1080/01480545.2026.2633380,https://pubmed.ncbi.nlm.nih.gov/41732886/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,42587863,"Integrating Peptidomics, Network Pharmacology, Molecular Docking, and In Vitro α-Glucosidase Inhibition Assays to Explore the Hypoglycemic Activity and Action Mechanisms of Chinese Yam Peptides.",2026,10.3390/foods15152603,https://pubmed.ncbi.nlm.nih.gov/42587863/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,40605709,&lt;i&gt;PTPN11&lt;/i&gt; mutations define a rare but highly adverse subset of myelodysplastic syndromes.,2025,10.3324/haematol.2025.287874,https://pubmed.ncbi.nlm.nih.gov/40605709/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,42302220,Clinical Utility of Rapid Whole-Genome Sequencing in Hospitalized Adults With Unexplained Neurologic Presentations.,2026,10.1212/wnl.0000000000218151,https://pubmed.ncbi.nlm.nih.gov/42302220/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,42466850,Decoding SHP2 mutations by computational saturation mutagenesis.,2026,10.1093/jmcb/mjag022,https://pubmed.ncbi.nlm.nih.gov/42466850/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,41671956,"Environmental flame retardant EHDPP stabilizes EGFR to accelerate lung cancer progression: Integrated network toxicology, bioinformatics, and in vitro evidence.",2026,10.1016/j.ecoenv.2026.119854,https://pubmed.ncbi.nlm.nih.gov/41671956/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,42075882,Repurposing Product Nkabinde for Hepatitis B Virus Therapy: A Network Pharmacology and Molecular Docking Investigation.,2026,10.3390/ph19040627,https://pubmed.ncbi.nlm.nih.gov/42075882/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,8216283,"Cloning, expression and mutational analysis of SH-PTP2, human protein-tyrosine phosphatase.",1993,10.1006/bbrc.1993.2224,https://pubmed.ncbi.nlm.nih.gov/8216283/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,7681589,A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains.,1993,10.1073/pnas.90.6.2197,https://pubmed.ncbi.nlm.nih.gov/7681589/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPN11,ENSG00000179295,Unsafe,1280823,Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.,1992,10.1073/pnas.89.23.11239,https://pubmed.ncbi.nlm.nih.gov/1280823/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,41866947,Nucleolin is essential for hair cell stereocilia maintenance and auditory function in mice.,2026,10.1242/jcs.264793,https://pubmed.ncbi.nlm.nih.gov/41866947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,41069440,Whole Exome Sequencing Identifies Novel Splicing Variants in the PTPRQ Gene and Their Mechanisms in Autosomal Recessive Non-Syndromic Hearing Loss.,2025,10.26599/joto.2025.9540031,https://pubmed.ncbi.nlm.nih.gov/41069440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,40165225,"Whole-genome sequencing, as a powerful diagnostic tool in hearing loss, reveals novel variants in PTPRQ missed by whole-exome sequencing.",2025,10.1186/s12920-025-02122-7,https://pubmed.ncbi.nlm.nih.gov/40165225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,39205941,Novel PTPRQ variants associated with hearing loss in a Chinese family PTPRQ variants in Chinese hearing loss.,2024,10.3389/fgene.2024.1399760,https://pubmed.ncbi.nlm.nih.gov/39205941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,40471101,Taperin bundles F-actin at stereocilia pivot points enabling optimal lifelong mechanosensitivity.,2025,10.1083/jcb.202408026,https://pubmed.ncbi.nlm.nih.gov/40471101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,39434500,A Novel PTPRQ c.3697del Variant Causes Autosomal Dominant Progressive Hearing Loss in Both Humans and Mice.,2025,10.1111/cge.14634,https://pubmed.ncbi.nlm.nih.gov/39434500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,38674423,Detailed Clinical Features of &lt;i&gt;PTPRQ&lt;/i&gt;-Associated Hearing Loss Identified in a Large Japanese Hearing Loss Cohort.,2024,10.3390/genes15040489,https://pubmed.ncbi.nlm.nih.gov/38674423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,33035386,Protein tyrosine phosphatase receptor type Q in cerebrospinal fluid reflects ependymal cell dysfunction and is a potential biomarker for adult chronic hydrocephalus.,2021,10.1111/ene.14575,https://pubmed.ncbi.nlm.nih.gov/33035386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,39850168,"Novel Syndrome With Congenital Thumb Aplasia, Epilepsy, Cognitive Impairment, and Myopathy: A Case Report.",2024,10.7759/cureus.76302,https://pubmed.ncbi.nlm.nih.gov/39850168/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,37350390,Identification of potential prognostic markers for lung adenocarcinoma using comprehensive analysis.,2023,10.3892/mmr.2023.13036,https://pubmed.ncbi.nlm.nih.gov/37350390/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,37106574,Delayed progressive sensorineural hearing loss due to a novel compound heterozygous PTPRQ mutation in a Chinese patient.,2023,10.1002/jcla.24886,https://pubmed.ncbi.nlm.nih.gov/37106574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,37952086,Critical role of TPRN rings in the stereocilia for hearing.,2024,10.1016/j.ymthe.2023.11.011,https://pubmed.ncbi.nlm.nih.gov/37952086/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,40501308,ATOH-1 Gene Therapy in Acquired Sensorineural Hearing Loss: A Meta-Analysis and Bioinformatic Analysis of Preclinical Studies.,2025,10.1089/hum.2025.013,https://pubmed.ncbi.nlm.nih.gov/40501308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,38162163,Novel FERMT3 and PTPRQ Mutations Associated with Leukocyte Adhesion Deficiency-III and Sensorineural Hearing Loss.,2023,10.1055/s-0041-1733948,https://pubmed.ncbi.nlm.nih.gov/38162163/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,35899188,Targeted Next-Generation Sequencing Identified Novel Compound Heterozygous Variants in the PTPRQ Gene Causing Autosomal Recessive Hearing Loss in a Chinese Family.,2022,10.3389/fgene.2022.884522,https://pubmed.ncbi.nlm.nih.gov/35899188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,28714010,PTPRQ as a potential biomarker for idiopathic normal pressure hydrocephalus.,2017,10.3892/mmr.2017.7015,https://pubmed.ncbi.nlm.nih.gov/28714010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,38826689,A cell type-specific approach to elucidate the role of miR-96 in inner ear hair cells.,2024,10.3389/fauot.2024.1400576,https://pubmed.ncbi.nlm.nih.gov/38826689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,39042286,Bioinformatic analysis predicts the regulatory function of noncoding SNPs associated with Long COVID-19 syndrome.,2024,10.1007/s00251-024-01348-6,https://pubmed.ncbi.nlm.nih.gov/39042286/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,29309402,"A C-terminal nonsense mutation links PTPRQ with autosomal-dominant hearing loss, DFNA73.",2018,10.1038/gim.2017.155,https://pubmed.ncbi.nlm.nih.gov/29309402/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,31655630,First confirmatory study on PTPRQ as an autosomal dominant non-syndromic hearing loss gene.,2019,10.1186/s12967-019-2099-5,https://pubmed.ncbi.nlm.nih.gov/31655630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,36153509,Mutational and transcriptional alterations and clinicopathological factors predict the prognosis of stage I hepatocellular carcinoma : Prediction of stage I HCC prognosis.,2022,10.1186/s12876-022-02496-3,https://pubmed.ncbi.nlm.nih.gov/36153509/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,28210624,RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis.,2017,10.1155/2017/8032910,https://pubmed.ncbi.nlm.nih.gov/28210624/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTPRQ,ENSG00000139304,Unsafe,24505276,Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 rearrangements.,2014,10.1371/journal.pone.0087113,https://pubmed.ncbi.nlm.nih.gov/24505276/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTRH1,ENSG00000187024,Unsafe,41216283,Development of a novel prognostic prediction model using mitochondrial-related genes and single-cell sequencing data for colorectal carcinoma.,2025,10.21037/tgh-25-89,https://pubmed.ncbi.nlm.nih.gov/41216283/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTRH1,ENSG00000187024,Unsafe,37434177,High glucose-upregulated PD-L1 expression through RAS signaling-driven downregulation of PTRH1 leads to suppression of T cell cytotoxic function in tumor environment.,2023,10.1186/s12967-023-04302-4,https://pubmed.ncbi.nlm.nih.gov/37434177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTRH1,ENSG00000187024,Unsafe,35064685,Global interpretation of novel alternative splicing events in human congenital pulmonary airway malformations: A pilot study.,2022,10.1002/jcb.30216,https://pubmed.ncbi.nlm.nih.gov/35064685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTRH1,ENSG00000187024,Unsafe,33193701,Molecular Characterization and Clinical Relevance of RNA Binding Proteins in Colorectal Cancer.,2020,10.3389/fgene.2020.580149,https://pubmed.ncbi.nlm.nih.gov/33193701/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTRH1,ENSG00000187024,Unsafe,34169901,Molecular characterization of colorectal cancer: A five-gene prognostic signature based on RNA-binding proteins.,2021,10.4103/sjg.sjg_530_20,https://pubmed.ncbi.nlm.nih.gov/34169901/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTRH1,ENSG00000187024,Unsafe,30244831,Release of Ubiquitinated and Non-ubiquitinated Nascent Chains from Stalled Mammalian Ribosomal Complexes by ANKZF1 and Ptrh1.,2018,10.1016/j.molcel.2018.08.022,https://pubmed.ncbi.nlm.nih.gov/30244831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTRH1,ENSG00000187024,Unsafe,3096819,Molecular cloning of the phosphoenolpyruvate carboxylase gene of Anabaena variabilis.,1986,10.1016/0378-1119(86)90139-3,https://pubmed.ncbi.nlm.nih.gov/3096819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,41976385,Intranuclear Peripheral Overexpression of Pituitary-Tumor-Transforming Gene 1: Immunohistochemical Biomarker of Lymph Node Involvement in Testicular Seminoma.,2026,10.3390/cancers18071163,https://pubmed.ncbi.nlm.nih.gov/41976385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,40877987,"Decoding the PTTG family's contribution to LUAD pathogenesis: a comprehensive study on expression, epigenetics, and therapeutic interventions.",2025,10.1186/s41065-025-00545-x,https://pubmed.ncbi.nlm.nih.gov/40877987/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,42180979,PTTG1-DLX2 axis drives malignant progression of lung adenocarcinoma by activating the WNT/β-catenin signaling pathway.,2026,10.21037/tcr-2026-1-0165,https://pubmed.ncbi.nlm.nih.gov/42180979/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,42057142,PTTG1-mediated the transcription of c-myc promotes retinoblastoma progression.,2026,10.1186/s13008-026-00186-0,https://pubmed.ncbi.nlm.nih.gov/42057142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,42871965,&lt;i&gt;PTTG1&lt;/i&gt; drives intestinal-type gastric cancer progression via G2/M checkpoint-mediated cell-cycle reprogramming.,2026,10.1016/j.isci.2026.117742,https://pubmed.ncbi.nlm.nih.gov/42871965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,42763990,The AURKA-PTTG1 signaling axis induces enzalutamide resistance in prostate cancer.,2026,10.1016/j.urolonc.2026.08.010,https://pubmed.ncbi.nlm.nih.gov/42763990/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,39678599,"Comprehensive analysis of the pituitary tumor-transforming gene (PTTG) family in lung adenocarcinoma: diagnostic, prognostic, and therapeutic implications.",2024,10.62347/tsjb6900,https://pubmed.ncbi.nlm.nih.gov/39678599/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,42434759,Clinical and prognostic implications of pituitary tumor-transforming gene 1 in solid tumors.,2026,10.3389/fonc.2026.1734781,https://pubmed.ncbi.nlm.nih.gov/42434759/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,42139353,Functional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina.,2026,10.1126/sciadv.aea0542,https://pubmed.ncbi.nlm.nih.gov/42139353/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,41009526,Investigating Germ Cell Transition Genes in Breast Cancer: Exploring the Genesis of Cancer Testis-Associated Markers.,2025,10.3390/ijms26188958,https://pubmed.ncbi.nlm.nih.gov/41009526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,41472935,Identification and Validation of the Prognostic Value of PTTG1-Related Genes in Hepatocellular Carcinoma by Mendelian Randomization and Single-Cell Transcriptome Analysis.,2026,10.30498/ijb.2025.543634.4221,https://pubmed.ncbi.nlm.nih.gov/41472935/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,42765160,The PTTG1/AURKA Axis Drives Acquired Anlotinib Resistance in Non-Small Cell Lung Cancer by Remodeling the Tumor Immune Microenvironment.,2026,10.1002/biof.70153,https://pubmed.ncbi.nlm.nih.gov/42765160/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,42210102,"CCNA2, MAD2L1, AURKA, and PTTG1 promote proliferation and migration in hepatocellular carcinoma.",2026,10.1186/s12876-026-04845-y,https://pubmed.ncbi.nlm.nih.gov/42210102/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,41769203,&lt;i&gt;Clonorchis sinensis&lt;/i&gt; promotes hepatocellular carcinoma progression via a potential PTTG1-β-catenin-c-MYC axis.,2026,10.1016/j.fawpar.2026.e00320,https://pubmed.ncbi.nlm.nih.gov/41769203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,41645360,PTTG1 regulates the TGF-β/Smad pathway to promote the growth and metastasis of gastric cancer cells.,2026,10.1186/s41065-026-00647-0,https://pubmed.ncbi.nlm.nih.gov/41645360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,41573212,Are &lt;i&gt;PTTG1&lt;/i&gt; variants associated with tumor characteristics and p53/Ki-67 expression in pituitary neuroendocrine tumors.,2025,10.3389/fendo.2025.1717301,https://pubmed.ncbi.nlm.nih.gov/41573212/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,42384015,Hyperlactataemia in lymphoma-associated haemophagocytic lymphohistiocytosis: Linked to monocytic glycolysis and adverse prognosis.,2026,10.1111/bjh.70637,https://pubmed.ncbi.nlm.nih.gov/42384015/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,42196574,"Molecular Characterization of Ovarian Endometriosis in Saudi Arabian Women: Insights into Inflammatory, Autophagic, and Epigenetic Dysregulation.",2026,10.3390/ijms27104598,https://pubmed.ncbi.nlm.nih.gov/42196574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,40279046,The regulatory role of PTTG1 in proliferation and migration of thyroid cancer.,2025,10.1007/s12672-025-02405-6,https://pubmed.ncbi.nlm.nih.gov/40279046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,41312363,Multi-omics integration identifies ASPH and PTTG1 as potential causal drivers of lung adenocarcinoma progression and immune evasion.,2025,10.3389/fimmu.2025.1689275,https://pubmed.ncbi.nlm.nih.gov/41312363/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,41033896,PTTG1-mediated reprogramming of asparagine metabolism enhances DNA damage repair and leads to compromised antitumor immunity in prostate cancer.,2026,10.1016/j.urolonc.2025.09.005,https://pubmed.ncbi.nlm.nih.gov/41033896/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,41427984,Novel common target genes for breast cancer and colorectal cancer: a Mendelian randomization and spatial transcriptomics study.,2025,10.1007/s12672-025-03546-4,https://pubmed.ncbi.nlm.nih.gov/41427984/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,39455949,Multi-omics analysis identifies PTTG1 as a prognostic biomarker associated with immunotherapy and chemotherapy resistance.,2024,10.1186/s12885-024-13060-5,https://pubmed.ncbi.nlm.nih.gov/39455949/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,40585419,Exploring the role of key gene PTTG1 in clear cell renal carcinoma based on bioinformatics analysis and In-vitro cell experiments.,2025,10.1093/toxres/tfaf078,https://pubmed.ncbi.nlm.nih.gov/40585419/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,41264123,Inhibition of PTTG1 suppresses proliferation and promotes differentiation of neuroblastoma cells by inducing autophagy.,2025,10.1007/s00383-025-06246-w,https://pubmed.ncbi.nlm.nih.gov/41264123/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,41731449,Identification of glycolysis -correlative features for predicting prognosis and investigating immune landscape in prostate cancer.,2026,10.1186/s12885-026-15723-x,https://pubmed.ncbi.nlm.nih.gov/41731449/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,42551718,An oxidative stress - and immunotherapy-related six-gene signature defines immune subtypes and predicts prognosis and immunotherapy response in hepatocellular carcinoma.,2026,10.1016/j.gene.2026.150335,https://pubmed.ncbi.nlm.nih.gov/42551718/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,39139816,Exploring the molecular landscape of osteosarcoma through PTTG family genes using a detailed multi-level methodology.,2024,10.3389/fgene.2024.1431668,https://pubmed.ncbi.nlm.nih.gov/39139816/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,39144144,Identification and validation of tryptophan-related gene signatures to predict prognosis and immunotherapy response in lung adenocarcinoma reveals a critical role for PTTG1.,2024,10.3389/fimmu.2024.1386427,https://pubmed.ncbi.nlm.nih.gov/39144144/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,40072059,The Role of RAC2 and PTTG1 in Cancer Biology.,2025,10.3390/cells14050330,https://pubmed.ncbi.nlm.nih.gov/40072059/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,40315269,Integration of single-cell and bulk RNA sequencing identifies and validates T cell-related prognostic model in hepatocellular carcinoma.,2025,10.1371/journal.pone.0322706,https://pubmed.ncbi.nlm.nih.gov/40315269/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PTTG1,ENSG00000164611,Unsafe,9811450,"hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG.",1998,10.1038/sj.onc.1202140,https://pubmed.ncbi.nlm.nih.gov/9811450/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PURG,ENSG00000172733,Unsafe,39676692,Transcriptomic and Metabolomic Analyses in Monozygotic and Dizygotic Twins.,2025,10.1002/ajmg.a.63971,https://pubmed.ncbi.nlm.nih.gov/39676692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PURG,ENSG00000172733,Unsafe,39133016,Lactate promotes the biofilm-to-invasive-planktonic transition in Salmonella enterica serovar Typhimurium via the de novo purine pathway.,2024,10.1128/iai.00266-24,https://pubmed.ncbi.nlm.nih.gov/39133016/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PURG,ENSG00000172733,Unsafe,38097166,A Human Adenovirus C Infection-Related Gene Panel for Predicting Survival and Treatment Responsiveness in Glioma Patients.,2024,10.1016/j.wneu.2023.12.051,https://pubmed.ncbi.nlm.nih.gov/38097166/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PURG,ENSG00000172733,Unsafe,37349795,"A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores.",2023,10.1186/s13024-023-00633-4,https://pubmed.ncbi.nlm.nih.gov/37349795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PURG,ENSG00000172733,Unsafe,29221753,"PURA, the gene encoding Pur-alpha, member of an ancient nucleic acid-binding protein family with mammalian neurological functions.",2018,10.1016/j.gene.2017.12.004,https://pubmed.ncbi.nlm.nih.gov/29221753/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PURG,ENSG00000172733,Unsafe,12034829,"Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation.",2002,10.1093/nar/30.11.2417,https://pubmed.ncbi.nlm.nih.gov/12034829/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PURG,ENSG00000172733,Unsafe,23298230,Proteomic comparison of historic and recently emerged hypervirulent Clostridium difficile strains.,2013,10.1021/pr3007528,https://pubmed.ncbi.nlm.nih.gov/23298230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PURG,ENSG00000172733,Unsafe,18726322,Regulation of purine biosynthetic genes expression inSalmonella typhimurium IV O(c) mutation site ofpurG and its function analysis.,1997,10.1007/bf02879082,https://pubmed.ncbi.nlm.nih.gov/18726322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PURG,ENSG00000172733,Unsafe,8161474,[Regulation of purine biosynthetic genes expression in Salmonella typhimurium. II. Isolation and characterization of Oc mutants].,1993,,https://pubmed.ncbi.nlm.nih.gov/8161474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PURG,ENSG00000172733,Unsafe,6343356,Identification of the enzymatic reactions encoded by the purG and purI genes of Escherichia coli.,1983,10.1128/jb.154.3.1485-1488.1983,https://pubmed.ncbi.nlm.nih.gov/6343356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PURG,ENSG00000172733,Unsafe,7045073,Isolation and characterization of purine regulatory mutants of Salmonella typhimurium with an episomal purE-lac fusion.,1982,10.1128/jb.151.1.153-161.1982,https://pubmed.ncbi.nlm.nih.gov/7045073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PURG,ENSG00000172733,Unsafe,374370,"Mapping hisS, the structural gene for histidyl-transfer ribonucleic acid synthetase, in Escherichia coli.",1979,10.1128/jb.138.1.264-267.1979,https://pubmed.ncbi.nlm.nih.gov/374370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PURG,ENSG00000172733,Unsafe,320198,Escherichia coli mutants deficient in exonuclease VII.,1977,10.1128/jb.129.2.934-947.1977,https://pubmed.ncbi.nlm.nih.gov/320198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
PURG,ENSG00000172733,Unsafe,204462,Microbial models and regulatory elements in the control of purine metabolism.,1977,10.1002/9780470720301.ch3,https://pubmed.ncbi.nlm.nih.gov/204462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
QRICH2,ENSG00000129646,Unsafe,41575150,Exploring QRICH2 as a potential male contraceptive target.,2026,10.1093/reprod/xaaf009,https://pubmed.ncbi.nlm.nih.gov/41575150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
QRICH2,ENSG00000129646,Unsafe,38597976,Metabolic profiling identifies Qrich2 as a novel glutamine sensor that regulates microtubule glutamylation and mitochondrial function in mouse sperm.,2024,10.1007/s00018-024-05177-4,https://pubmed.ncbi.nlm.nih.gov/38597976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
QRICH2,ENSG00000129646,Unsafe,40107860,Genetic variants in &lt;i&gt;QRICH2&lt;/i&gt; gene among Jordanians with sperm motility disorders.,2025,10.1080/19932820.2025.2481741,https://pubmed.ncbi.nlm.nih.gov/40107860/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
QRICH2,ENSG00000129646,Unsafe,37352829,CFAP70 is a solid and valuable target for the genetic diagnosis of oligo-astheno-teratozoospermia in infertile men.,2023,10.1016/j.ebiom.2023.104675,https://pubmed.ncbi.nlm.nih.gov/37352829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
QRICH2,ENSG00000129646,Unsafe,35255804,A 1-bp deletion in bovine QRICH2 causes low sperm count and immotile sperm with multiple morphological abnormalities.,2022,10.1186/s12711-022-00710-0,https://pubmed.ncbi.nlm.nih.gov/35255804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
QRICH2,ENSG00000129646,Unsafe,35886074,Further Insights on RNA Expression and Sperm Motility.,2022,10.3390/genes13071291,https://pubmed.ncbi.nlm.nih.gov/35886074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
QRICH2,ENSG00000129646,Unsafe,30683861,Loss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagella.,2019,10.1038/s41467-018-08182-x,https://pubmed.ncbi.nlm.nih.gov/30683861/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
QRICH2,ENSG00000129646,Unsafe,36017582,Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia.,2022,10.1111/andr.13269,https://pubmed.ncbi.nlm.nih.gov/36017582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
QRICH2,ENSG00000129646,Unsafe,34415320,Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development.,2021,10.1093/hmg/ddab234,https://pubmed.ncbi.nlm.nih.gov/34415320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
QRICH2,ENSG00000129646,Unsafe,38243319,Genomics and tumor microenvironment of breast mucoepidermoid carcinoma based on whole-exome and RNA sequencing.,2024,10.1186/s13000-024-01439-8,https://pubmed.ncbi.nlm.nih.gov/38243319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
QRICH2,ENSG00000129646,Unsafe,37338096,Cerebrospinal Fluid Protein Biomarker Discovery in CLN3.,2023,10.1021/acs.jproteome.3c00199,https://pubmed.ncbi.nlm.nih.gov/37338096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
QRICH2,ENSG00000129646,Unsafe,34089056,Exome sequencing reveals variants in known and novel candidate genes for severe sperm motility disorders.,2021,10.1093/humrep/deab099,https://pubmed.ncbi.nlm.nih.gov/34089056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
QRICH2,ENSG00000129646,Unsafe,36120567,The ribosome inhibitor chloramphenicol induces motility deficits in human spermatozoa: A proteomic approach identifies potentially involved proteins.,2022,10.3389/fcell.2022.965076,https://pubmed.ncbi.nlm.nih.gov/36120567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
QRICH2,ENSG00000129646,Unsafe,35641504,Structural variant-based pangenome construction has low sensitivity to variability of haplotype-resolved bovine assemblies.,2022,10.1038/s41467-022-30680-2,https://pubmed.ncbi.nlm.nih.gov/35641504/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
QRICH2,ENSG00000129646,Unsafe,32461543,Whole Exome Sequencing of Multiple Atypical Meningiomas in a Patient without History of Neurofibromatosis Type II: A Case Report.,2020,10.12659/ajcr.923928,https://pubmed.ncbi.nlm.nih.gov/32461543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
QRICH2,ENSG00000129646,Unsafe,31969344,"Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations.",2020,10.1158/1940-6207.capr-19-0496,https://pubmed.ncbi.nlm.nih.gov/31969344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
R3HCC1L,ENSG00000166024,Unsafe,37140987,Identification of long noncoding RNAs with aberrant expression in prostate cancer metastases.,2023,10.1530/erc-22-0247,https://pubmed.ncbi.nlm.nih.gov/37140987/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
R3HCC1L,ENSG00000166024,Unsafe,38200094,Strong selection signatures for Aleutian disease tolerance acting on novel candidate genes linked to immune and cellular responses in American mink (Neogale vison).,2024,10.1038/s41598-023-51039-7,https://pubmed.ncbi.nlm.nih.gov/38200094/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
R3HCC1L,ENSG00000166024,Unsafe,33357513,Host genetic effects in pneumonia.,2021,10.1016/j.ajhg.2020.12.010,https://pubmed.ncbi.nlm.nih.gov/33357513/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
R3HDML,ENSG00000101074,Unsafe,33620517,"A novel podocyte protein, R3h domain containing-like, inhibits TGF-β-induced p38 MAPK and regulates the structure of podocytes and glomerular basement membrane.",2021,10.1007/s00109-021-02050-w,https://pubmed.ncbi.nlm.nih.gov/33620517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
R3HDML,ENSG00000101074,Unsafe,31524320,R3hdml regulates satellite cell proliferation and differentiation.,2019,10.15252/embr.201947957,https://pubmed.ncbi.nlm.nih.gov/31524320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
R3HDML,ENSG00000101074,Unsafe,37866487,Bavachin combined with epimedin B induce idiosyncratic liver injury under immunological stress conditions.,2023,10.1016/j.cbi.2023.110774,https://pubmed.ncbi.nlm.nih.gov/37866487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
R3HDML,ENSG00000101074,Unsafe,22158537,Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.,2011,10.1038/ng.1019,https://pubmed.ncbi.nlm.nih.gov/22158537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,42227759,"Rab11Bis required for binding and entry of recent H3N2, but not H1N1, influenza A isolates.",2026,10.1128/jvi.02111-25,https://pubmed.ncbi.nlm.nih.gov/42227759/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,42511853,Prognostic and Diagnostic Significance of Annexin A1 in ypT3 Locally Advanced Rectal Cancer Patients.,2026,10.3390/ijms27146512,https://pubmed.ncbi.nlm.nih.gov/42511853/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,40248353,Rab11b is necessary for mitochondrial integrity and function in gut epithelial cells.,2025,10.3389/fcell.2025.1498902,https://pubmed.ncbi.nlm.nih.gov/40248353/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,42677123,Hypoxia-regulated non-coding RNAs in OSCC liquid biopsy: from molecular mechanisms to AI-driven precision oncology.,2026,10.3389/fonc.2026.1902907,https://pubmed.ncbi.nlm.nih.gov/42677123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,41609088,Long Non-Coding RNA &lt;i&gt;RAB11B-AS1&lt;/i&gt; Suppresses Cervical Cancer Progression by Upregulating &lt;i&gt;RPL26&lt;/i&gt; Expression.,2026,10.31083/fbl47597,https://pubmed.ncbi.nlm.nih.gov/41609088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,41493130,"Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell-cell junctions during neural tube formation.",2026,10.1002/dvdy.70109,https://pubmed.ncbi.nlm.nih.gov/41493130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,42639838,DENND3-p.R534S disrupts dyadic microdomain architecture to drive potentially pro-arrhythmic calcium and electrophysiologic instability.,2026,10.1093/europace/euag193,https://pubmed.ncbi.nlm.nih.gov/42639838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,39883192,"Distribution analysis of RAB11A and RAB11B, small GTP-binding proteins, in mice.",2025,10.1007/s11033-025-10282-z,https://pubmed.ncbi.nlm.nih.gov/39883192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,41882227,GTPase Rab11b and effector Rab11-FIP2 promote NLRP3 stability during inflammasome priming.,2026,10.1038/s44318-026-00755-7,https://pubmed.ncbi.nlm.nih.gov/41882227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,41605412,Integrated miRNA-proteomic profiling identifies chronic vesicle-trafficking and proteostasis disruptions after mild traumatic brain injury.,2026,10.1016/j.expneurol.2026.115652,https://pubmed.ncbi.nlm.nih.gov/41605412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,38992121,Rab11b promotes M1-like macrophage polarization by restraining autophagic degradation of NLRP3 in alcohol-associated liver disease.,2025,10.1038/s41401-024-01333-5,https://pubmed.ncbi.nlm.nih.gov/38992121/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,40564019,"CD133 and CD166 Stem Cells Markers Expression, Clinicopathological Parameters, and Fragmentation Response Patterns of ypT3 Rectal Cancer Following Neoadjuvant Chemoradiotherapy.",2025,10.3390/biomedicines13061300,https://pubmed.ncbi.nlm.nih.gov/40564019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,40877912,The unique contributions of Rab11 and Rab35 to the completion of cell division.,2025,10.1186/s40659-025-00638-x,https://pubmed.ncbi.nlm.nih.gov/40877912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,41083438,Mesenchymal stromal cells induce neutrophil aggregation and extracellular vesicle storms for systemic lupus erythematosus.,2025,10.1038/s41392-025-02442-1,https://pubmed.ncbi.nlm.nih.gov/41083438/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,38072191,Rab11 suppresses head and neck carcinoma by regulating EGFR and EpCAM exosome secretion.,2024,10.1016/j.job.2023.11.007,https://pubmed.ncbi.nlm.nih.gov/38072191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,40679295,"Single-cell RNA sequencing reveals hemocyte heterogeneity, differentiation trajectories, and viral tropism in shrimp (&lt;i&gt;Macrobrachium rosenbergii&lt;/i&gt;) infected with decapodiridovirus litopenaeus1.",2025,10.1128/jvi.00790-25,https://pubmed.ncbi.nlm.nih.gov/40679295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,40735467,The Benefits of Adjuvant Chemotherapy for ypT3-4N0M0 Rectal Cancer Following Neoadjuvant Chemoradiation and Surgery.,2025,10.1177/11795549251359151,https://pubmed.ncbi.nlm.nih.gov/40735467/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,40614209,Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration.,2025,10.1126/sciadv.adu6361,https://pubmed.ncbi.nlm.nih.gov/40614209/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,39468641,Novel TBC1D8B variant causes neonatal nephrotic syndrome combined with acute kidney injury.,2024,10.1186/s13052-024-01790-y,https://pubmed.ncbi.nlm.nih.gov/39468641/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,40651076,IRF6 regulates adherens junction proteins and inflammatory cytokines in salivary acinar cells and its expression is elevated in Sjӧgren's syndrome.,2025,10.1016/j.archoralbio.2025.106348,https://pubmed.ncbi.nlm.nih.gov/40651076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,42512335,Impact of Adding Immune Checkpoint Inhibitors to Neoadjuvant Chemotherapy on pCR and Tumor Downstaging in Resectable Gastric Cancer: A Meta-Analysis.,2026,10.3390/cancers18142270,https://pubmed.ncbi.nlm.nih.gov/42512335/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,42323768,Toxicity outcomes of concurrent radiotherapy with adjuvant capecitabine in triple-negative breast cancer (TROD 06-24).,2026,10.1007/s12672-026-05481-4,https://pubmed.ncbi.nlm.nih.gov/42323768/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,41463235,Perioperative Chemotherapy in Bladder and Upper Tract Urothelial Carcinoma: Outcomes by Nodal Status and Lymphovascular Invasion.,2025,10.3390/cancers17243986,https://pubmed.ncbi.nlm.nih.gov/41463235/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,41357221,Efficacy and safety of postoperative radiotherapy in locally advanced esophageal squamous cell carcinoma patients with pathologic incomplete response after neoadjuvant immunochemotherapy: a retrospective cohort study.,2025,10.3389/fimmu.2025.1660097,https://pubmed.ncbi.nlm.nih.gov/41357221/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,41537282,Validation and refinement of the AJCC 8th edition ypStage in esophageal squamous cell carcinoma after neoadjuvant therapy: a large-scale retrospective cohort study.,2026,10.1097/js9.0000000000004776,https://pubmed.ncbi.nlm.nih.gov/41537282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,42477761,Residual tumor deposits after neoadjuvant therapy and 3-year survival outcomes in gastric cancer: a single-center retrospective cohort study.,2026,10.1186/s12957-026-04500-6,https://pubmed.ncbi.nlm.nih.gov/42477761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,42323452,Adjuvant Immunotherapy Improves Esophageal Squamous Cell Carcinoma Survival After Neoadjuvant Chemoimmunotherapy: A Multicenter Real-World Study.,2026,10.1245/s10434-026-19900-x,https://pubmed.ncbi.nlm.nih.gov/42323452/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,40066458,Survival benefits of postoperative radiotherapy in esophageal cancer during the immunotherapy era:a retrospective cohort study based on the SEER database and a single-center registry in China.,2025,10.3389/fimmu.2025.1548520,https://pubmed.ncbi.nlm.nih.gov/40066458/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,42808119,Splenic-preserving total duodenopancreatectomy and a conservative postoperative management: a case report.,2026,10.1093/jscr/rjag858,https://pubmed.ncbi.nlm.nih.gov/42808119/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,42466102,Impact of postoperative chemotherapy in patients resected for esophagogastric adenocarcinoma with major pathological response after preoperative chemotherapy: a study from the FREGAT database.,2026,10.1177/17588359261435406,https://pubmed.ncbi.nlm.nih.gov/42466102/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,41904547,Predictors of survival for locally advanced rectal cancer patients with poor response to neoadjuvant chemoradiotherapy.,2026,10.1186/s13014-026-02820-1,https://pubmed.ncbi.nlm.nih.gov/41904547/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,40690079,The role of RAB GTPases in predicting prognosis and therapy response in pancreatic cancer.,2025,10.1007/s12672-025-03209-4,https://pubmed.ncbi.nlm.nih.gov/40690079/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,40944434,Tumor Regression Grade as a Predictor of Adjuvant Therapy Benefits in Esophageal Squamous Cell Carcinoma Patients After Neoadjuvant Therapy.,2025,10.1002/cam4.71166,https://pubmed.ncbi.nlm.nih.gov/40944434/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,41476583,Development and external validation of a prognostic nomogram for event-free survival in resectable non-small cell lung cancer after neoadjuvant chemoimmunotherapy.,2025,10.3389/fonc.2025.1682497,https://pubmed.ncbi.nlm.nih.gov/41476583/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB11B,ENSG00000185236,Unsafe,38088519,Camrelizumab in combination with neoadjuvant chemotherapy in resectable locally advanced esophageal squamous carcinoma cancer: Results from a retrospective study.,2024,10.1002/kjm2.12793,https://pubmed.ncbi.nlm.nih.gov/38088519/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,42121002,Knockout of Rab27b exacerbates neuropathology in alpha-synuclein mouse models.,2026,10.1186/s40478-026-02321-y,https://pubmed.ncbi.nlm.nih.gov/42121002/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,42584685,Cross-tissue Mendelian randomization prioritizes RAB27B as a brain-derived candidate protein for postpartum depression.,2026,10.1007/s00406-026-02349-0,https://pubmed.ncbi.nlm.nih.gov/42584685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,42826760,Identification of a shared blood-brain transcriptomic signature in Parkinson's disease using bioinformatic and network pharmacology approaches.,2026,10.1016/j.neuroscience.2026.09.044,https://pubmed.ncbi.nlm.nih.gov/42826760/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,42370221,Diosgenin Promotes Bacterial Clearance in Bladder Epithelial Cells by Regulating Rab27b Expression: A Study Based on Virtual Screening and Experimental Validation.,2026,10.2147/idr.s600133,https://pubmed.ncbi.nlm.nih.gov/42370221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,42679617,Altered mRNA and protein expression of exosome-related markers in bile duct ligation-induced liver fibrosis in rats.,2026,10.1016/j.tice.2026.103909,https://pubmed.ncbi.nlm.nih.gov/42679617/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,41796324,Genetic subtraction reveals divergent pathways and targets in anxiety-related and anxiety-independent TMD.,2026,10.1186/s10194-026-02304-3,https://pubmed.ncbi.nlm.nih.gov/41796324/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,40399992,Mechanism of LINC01018/miR-182-5p/Rab27B in the immune escape through PD-L1-mediated CD8&lt;sup&gt;+&lt;/sup&gt; T cell suppression in glioma.,2025,10.1186/s13062-025-00651-w,https://pubmed.ncbi.nlm.nih.gov/40399992/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,42050540,Shared genetic architecture between Alzheimer's disease and psychiatric disorders revealed by multi-trait genome-wide analyses.,2026,10.1186/s12920-026-02354-1,https://pubmed.ncbi.nlm.nih.gov/42050540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,42510937,Cisplatin-Induced Rab27A/B Exosomal PD-L1 Axis Suppresses Antitumor Immunity and Correlates with Poor 5-Year Survival in Lung Squamous Cell Carcinoma and Adenocarcinoma.,2026,10.3390/cimb48070697,https://pubmed.ncbi.nlm.nih.gov/42510937/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,41606526,Proteome profiling reveals early diagnostic biomarker candidates for colorectal cancer.,2026,10.1186/s12885-026-15547-9,https://pubmed.ncbi.nlm.nih.gov/41606526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,42138205,Rab27: Molecular switch of tumor exosome secretion (Review).,2026,10.3892/ijmm.2026.5853,https://pubmed.ncbi.nlm.nih.gov/42138205/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,40352946,DDX10 Exacerbates Exosomal PD-L1-Dependent T Cell Exhaustion via Phase Separation of Rab27b in Oral Squamous Cell Carcinoma.,2025,10.34133/research.0697,https://pubmed.ncbi.nlm.nih.gov/40352946/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,39965930,Rab27b Promotes Lysosomal Function and Alpha-Synuclein Clearance in Neurons.,2025,10.1523/jneurosci.1579-24.2025,https://pubmed.ncbi.nlm.nih.gov/39965930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,42020315,Rab27b: A Modulator of Lysosomal Function and Alpha-Synuclein Clearance in Parkinson's Disease.,2026,10.1523/jneurosci.0917-25.2026,https://pubmed.ncbi.nlm.nih.gov/42020315/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,39542128,Regulation of autophagy by Rab27B in colorectal cancer.,2024,10.1016/j.biocel.2024.106693,https://pubmed.ncbi.nlm.nih.gov/39542128/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,42666019,Skeletal Muscle-Derived Extracellular Vesicles During Eccentric and Concentric Exercise Promote Muscle Regeneration After Injury.,2026,10.1002/jcsm.70374,https://pubmed.ncbi.nlm.nih.gov/42666019/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,40972800,Rab27b-mediated CAFs derived exosomal miR-22-3p suppresses ferroptosis and promotes cisplatin resistance in osteosarcoma.,2025,10.1016/j.cellsig.2025.112125,https://pubmed.ncbi.nlm.nih.gov/40972800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,41163097,Microgravity-driven Rab27B activation amplifies mesenchymal stem cell-derived extracellular vesicle production and functions.,2025,10.1186/s13287-025-04711-w,https://pubmed.ncbi.nlm.nih.gov/41163097/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,41407005,Integrating Multi-Omics Summary Data Identifies Candidate Molecular Mechanisms for Major Depression.,2026,10.1016/j.biopsych.2025.11.024,https://pubmed.ncbi.nlm.nih.gov/41407005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,42169933,A TRPM4-associated necrotic cell death signature for prognostic stratification in pancreatic cancer.,2026,10.21037/jgo-2025-1-968,https://pubmed.ncbi.nlm.nih.gov/42169933/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,41160086,Decoding Dendritic Cell Subtypes via Integrated Radiogenomics: A Stacked Ensemble Model for Predicting Immunotherapy Response in NSCLC.,2025,10.1096/fj.202501990r,https://pubmed.ncbi.nlm.nih.gov/41160086/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,41226368,EZH2 Inhibition in Mesothelioma Cells Increases the Release of Extracellular Vesicles That Skew Neutrophils Toward a Protumor Phenotype.,2025,10.3390/ijms262110328,https://pubmed.ncbi.nlm.nih.gov/41226368/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,39723610,TGF-β regulates the release of breast cancer cell-derived extracellular vesicles and the sorting of their protein cargo by downregulating RAB27B expression.,2024,10.1002/jev2.70026,https://pubmed.ncbi.nlm.nih.gov/39723610/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,41050095,pH-responsive 2D niobium carbide nanosheets for targeted circPUM1 siRNA delivery in ovarian cancer therapy.,2025,10.1016/j.mtbio.2025.102314,https://pubmed.ncbi.nlm.nih.gov/41050095/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,41453737,Transmembrane protein 16F-chloride intracellular channel 1 interaction mediates recipient dendritic cell cross-decoration after transplantation.,2026,10.1016/j.ajt.2025.12.020,https://pubmed.ncbi.nlm.nih.gov/41453737/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,39430819,Construction of a prognostic model with exosome biogenesis- and release-related genes and identification of RAB27B in immune infiltration of pancreatic cancer.,2024,10.21037/tcr-24-54,https://pubmed.ncbi.nlm.nih.gov/39430819/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,39071697,Single cell transcriptomic analysis reveals tumor immune infiltration by NK cells gene signature in lung adenocarcinoma.,2024,10.1016/j.heliyon.2024.e33928,https://pubmed.ncbi.nlm.nih.gov/39071697/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,37248891,RAB27B expression in pancreatic cancer is predictive of poor survival but good response to chemotherapy.,2023,10.3233/cbm-220460,https://pubmed.ncbi.nlm.nih.gov/37248891/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB27B,ENSG00000041353,Unsafe,37604869,Identification and validation of tumor microenvironment-related signature for predicting prognosis and immunotherapy response in patients with lung adenocarcinoma.,2023,10.1038/s41598-023-40980-2,https://pubmed.ncbi.nlm.nih.gov/37604869/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB41,ENSG00000147127,Unsafe,37802980,Rab41-mediated ESCRT machinery repairs membrane rupture by a bacterial toxin in xenophagy.,2023,10.1038/s41467-023-42039-2,https://pubmed.ncbi.nlm.nih.gov/37802980/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB41,ENSG00000147127,Unsafe,35237504,SP1-Mediated Upregulation of circFAM126A Promotes Proliferation and Epithelial-Mesenchymal Transition of Oral Squamous Cell Carcinoma via Regulation of RAB41.,2022,10.3389/fonc.2022.715534,https://pubmed.ncbi.nlm.nih.gov/35237504/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB41,ENSG00000147127,Unsafe,37240180,Multi-Omics Data Integration Reveals Key Variables Contributing to Subgingival Microbiome Dysbiosis-Induced Inflammatory Response in a Hyperglycemic Microenvironment.,2023,10.3390/ijms24108832,https://pubmed.ncbi.nlm.nih.gov/37240180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB41,ENSG00000147127,Unsafe,26973836,Identification of Rab41/6d Effectors Provides an Explanation for the Differential Effects of Rab41/6d and Rab6a/a' on Golgi Organization.,2016,10.3389/fcell.2016.00013,https://pubmed.ncbi.nlm.nih.gov/26973836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB41,ENSG00000147127,Unsafe,23936529,Rab41 is a novel regulator of Golgi apparatus organization that is needed for ER-to-Golgi trafficking and cell growth.,2013,10.1371/journal.pone.0071886,https://pubmed.ncbi.nlm.nih.gov/23936529/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB41,ENSG00000147127,Unsafe,29582580,"Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1-mediated K63-linked ubiquitination.",2018,10.1111/cmi.12846,https://pubmed.ncbi.nlm.nih.gov/29582580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB41,ENSG00000147127,Unsafe,25708460,How Rab proteins determine Golgi structure.,2015,10.1016/bs.ircmb.2014.12.002,https://pubmed.ncbi.nlm.nih.gov/25708460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB41,ENSG00000147127,Unsafe,33415023,"Classify multicategory outcome in patients with lung adenocarcinoma using clinical, transcriptomic and clinico-transcriptomic data: machine learning versus multinomial models.",2020,,https://pubmed.ncbi.nlm.nih.gov/33415023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAB41,ENSG00000147127,Unsafe,15018353,"Isolation, expression pattern of a novel human RAB gene RAB41 and characterization of its intronless homolog RAB41P.",2003,10.1080/10425170310001617902,https://pubmed.ncbi.nlm.nih.gov/15018353/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,41912541,Lipid turnover and GEF recruitment collectively determine Rab5 recruitment and activation during the first step of early endosome formation.,2026,10.1038/s41467-026-70543-8,https://pubmed.ncbi.nlm.nih.gov/41912541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,39576689,Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation.,2024,10.7554/elife.96353,https://pubmed.ncbi.nlm.nih.gov/39576689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,40605338,ESCRTing the RABs through conversion.,2025,10.1042/bst20253007,https://pubmed.ncbi.nlm.nih.gov/40605338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,38660223,Coordination among frequent genetic variants imparts substance use susceptibility and pathogenesis.,2024,10.3389/fnins.2024.1332419,https://pubmed.ncbi.nlm.nih.gov/38660223/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,38862997,Development of novel lysosome-related signatures and their potential target drugs based on bulk RNA-seq and scRNA-seq for diabetic foot ulcers.,2024,10.1186/s40246-024-00629-1,https://pubmed.ncbi.nlm.nih.gov/38862997/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,38971819,ATP6V0A1-dependent cholesterol absorption in colorectal cancer cells triggers immunosuppressive signaling to inactivate memory CD8&lt;sup&gt;+&lt;/sup&gt; T cells.,2024,10.1038/s41467-024-50077-7,https://pubmed.ncbi.nlm.nih.gov/38971819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,33166495,RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.,2021,10.1016/j.yexmp.2020.104571,https://pubmed.ncbi.nlm.nih.gov/33166495/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,39466792,"Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development.",2024,10.1371/journal.pone.0312274,https://pubmed.ncbi.nlm.nih.gov/39466792/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,37610843,Altered G-Protein Transduction Protein Gene Expression in the Testis of Infertile Patients with Nonobstructive Azoospermia.,2023,10.1089/dna.2023.0189,https://pubmed.ncbi.nlm.nih.gov/37610843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,33362196,Loss of endocytosis-associated RabGEF1 causes aberrant morphogenesis and altered autophagy in photoreceptors leading to retinal degeneration.,2020,10.1371/journal.pgen.1009259,https://pubmed.ncbi.nlm.nih.gov/33362196/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,37682707,Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer.,2023,10.1016/j.celrep.2023.113003,https://pubmed.ncbi.nlm.nih.gov/37682707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,37787182,GPRASP1 loss-of-function links to arteriovenous malformations by endothelial activating GPR4 signals.,2024,10.1093/brain/awad335,https://pubmed.ncbi.nlm.nih.gov/37787182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,31718772,"Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding.",2019,10.7554/elife.46302,https://pubmed.ncbi.nlm.nih.gov/31718772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,31628426,Epithelial RABGEF1 deficiency promotes intestinal inflammation by dysregulating intrinsic MYD88-dependent innate signaling.,2020,10.1038/s41385-019-0211-z,https://pubmed.ncbi.nlm.nih.gov/31628426/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,32510320,A non-linear system patterns Rab5 GTPase on the membrane.,2020,10.7554/elife.54434,https://pubmed.ncbi.nlm.nih.gov/32510320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,26430212,Rabaptin5 is recruited to endosomes by Rab4 and Rabex5 to regulate endosome maturation.,2015,10.1242/jcs.174664,https://pubmed.ncbi.nlm.nih.gov/26430212/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,27820702,Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis.,2016,10.1172/jci86359,https://pubmed.ncbi.nlm.nih.gov/27820702/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,26588713,RabGEF1/Rabex-5 Regulates TrkA-Mediated Neurite Outgrowth and NMDA-Induced Signaling Activation in NGF-Differentiated PC12 Cells.,2015,10.1371/journal.pone.0142935,https://pubmed.ncbi.nlm.nih.gov/26588713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,31528310,Highlighted role of VEGFA in follow up of celiac disease.,2019,,https://pubmed.ncbi.nlm.nih.gov/31528310/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,32559233,"A conserved, N-terminal tyrosine signal directs Ras for inhibition by Rabex-5.",2020,10.1371/journal.pgen.1008715,https://pubmed.ncbi.nlm.nih.gov/32559233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,29603841,Regulation of early endosomes across eukaryotes: Evolution and functional homology of Vps9 proteins.,2018,10.1111/tra.12570,https://pubmed.ncbi.nlm.nih.gov/29603841/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,25302364,The biology of A20-like molecules.,2014,10.1007/978-1-4939-0398-6_3,https://pubmed.ncbi.nlm.nih.gov/25302364/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,27791468,The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes.,2017,10.1080/15548627.2016.1241924,https://pubmed.ncbi.nlm.nih.gov/27791468/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,20829437,"Thymic stromal lymphopoietin contributes to myeloid hyperplasia and increased immunoglobulins, but not epidermal hyperplasia, in RabGEF1-deficient mice.",2010,10.2353/ajpath.2010.100181,https://pubmed.ncbi.nlm.nih.gov/20829437/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,30818875,"Gliosarcoma Is Driven by Alterations in PI3K/Akt, RAS/MAPK Pathways and Characterized by Collagen Gene Expression Signature.",2019,10.3390/cancers11030284,https://pubmed.ncbi.nlm.nih.gov/30818875/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,27037361,Enhanced Purification of Ubiquitinated Proteins by Engineered Tandem Hybrid Ubiquitin-binding Domains (ThUBDs).,2016,10.1074/mcp.o115.051839,https://pubmed.ncbi.nlm.nih.gov/27037361/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,24155895,Identification of novel predictor classifiers for inflammatory bowel disease by gene expression profiling.,2013,10.1371/journal.pone.0076235,https://pubmed.ncbi.nlm.nih.gov/24155895/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,22984654,Beta-amyloid toxicity modifier genes and the risk of Alzheimer's disease.,2012,,https://pubmed.ncbi.nlm.nih.gov/22984654/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,20655225,Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination.,2010,10.1016/j.cub.2010.06.051,https://pubmed.ncbi.nlm.nih.gov/20655225/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABGEF1,ENSG00000154710,Unsafe,23065012,Systemic steroid exposure is associated with differential methylation in chronic obstructive pulmonary disease.,2012,10.1164/rccm.201207-1280oc,https://pubmed.ncbi.nlm.nih.gov/23065012/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABL3,ENSG00000144840,Unsafe,31748878,Identification of GIMAP7 and Rabl3 as Putative Biomarkers for Oral Squamous Cell Carcinoma Through Comparative Proteomic Approach.,2020,10.1007/s12253-019-00775-1,https://pubmed.ncbi.nlm.nih.gov/31748878/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABL3,ENSG00000144840,Unsafe,34631898,circCOL1A1 Promotes the Progression of Gastric Cancer Cells through Sponging miR-145 to Enhance RABL3 Expression.,2021,10.1155/2021/6724854,https://pubmed.ncbi.nlm.nih.gov/34631898/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABL3,ENSG00000144840,Unsafe,32220963,Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function.,2020,10.1073/pnas.2000703117,https://pubmed.ncbi.nlm.nih.gov/32220963/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABL3,ENSG00000144840,Unsafe,33438143,Knockdown of RABL3 suppresses the proliferation and invasion of oral squamous cell carcinoma through inactivating the FAK/AKT pathway.,2021,10.1007/s10863-021-09871-x,https://pubmed.ncbi.nlm.nih.gov/33438143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABL3,ENSG00000144840,Unsafe,31406347,Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer.,2019,10.1038/s41588-019-0475-y,https://pubmed.ncbi.nlm.nih.gov/31406347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABL3,ENSG00000144840,Unsafe,33015775,Long non-coding RNA LINC00858 promotes cells proliferation and invasion through the miR-153-3p/Rabl3 axis in hepatocellular carcinoma.,2020,10.26355/eurrev_202009_23017,https://pubmed.ncbi.nlm.nih.gov/33015775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABL3,ENSG00000144840,Unsafe,31298353,MiR-296-3p may affect the proliferation and migration of non-small cell lung cancer cells via regulating RABL3.,2019,10.26355/eurrev_201907_18321,https://pubmed.ncbi.nlm.nih.gov/31298353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABL3,ENSG00000144840,Unsafe,28443498,The overexpression of Rabl3 is associated with pathogenesis and clinicopathologic variables in hepatocellular carcinoma.,2017,10.1177/1010428317696230,https://pubmed.ncbi.nlm.nih.gov/28443498/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABL3,ENSG00000144840,Unsafe,28739496,Overexpression of Rabl3 and Cullin7 is associated with pathogenesis and poor prognosis in hepatocellular carcinoma.,2017,10.1016/j.humpath.2017.07.008,https://pubmed.ncbi.nlm.nih.gov/28739496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABL3,ENSG00000144840,Unsafe,34222337,SmgGDS: An Emerging Master Regulator of Prenylation and Trafficking by Small GTPases in the Ras and Rho Families.,2021,10.3389/fmolb.2021.685135,https://pubmed.ncbi.nlm.nih.gov/34222337/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABL3,ENSG00000144840,Unsafe,27164297,High Expression of Rab-like 3 (Rabl3) is Associated with Poor Survival of Patients with Non-Small Cell Lung Cancer via Repression of MAPK8/9/10-Mediated Autophagy.,2016,10.12659/msm.898632,https://pubmed.ncbi.nlm.nih.gov/27164297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RABL3,ENSG00000144840,Unsafe,20596630,Evaluation of the novel gene Rabl3 in the regulation of proliferation and motility in human cancer cells.,2010,10.3892/or_00000876,https://pubmed.ncbi.nlm.nih.gov/20596630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42427290,Homologous recombination is essential for DNA damage-induced regeneration of Drosophila testis germline stem cells.,2026,10.1242/dev.205514,https://pubmed.ncbi.nlm.nih.gov/42427290/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,41979920,SCD1 and SCD5 modulate PARP-dependent DNA repair via fatty acid desaturation in glioblastoma.,2026,10.1016/j.celrep.2026.117223,https://pubmed.ncbi.nlm.nih.gov/41979920/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42133623,Cancer mutations in RAD51 and its paralogues.,2026,10.1371/journal.pone.0349105,https://pubmed.ncbi.nlm.nih.gov/42133623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42340890,LncRNA RAD51-AS1 Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy by Adsorbing miR-154-5p.,2026,10.1159/000552931,https://pubmed.ncbi.nlm.nih.gov/42340890/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42623469,RAD51 stabilizes neutrophil extracellular traps to compartmentalize inflammation.,2026,10.1126/science.aed9286,https://pubmed.ncbi.nlm.nih.gov/42623469/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42817804,METTL3 Increases Temozolomide Resistance in MGMT-Negative Glioblastoma by Enhancing CBX5 mRNA Stability in an m&lt;sup&gt;6&lt;/sup&gt;A-IGF2BP2-Dependent Manner.,2026,10.1002/cns.71164,https://pubmed.ncbi.nlm.nih.gov/42817804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42044161,Potential Rad54 separation of function mutation highlights unique roles during homologous recombination.,2026,10.1371/journal.pgen.1012136,https://pubmed.ncbi.nlm.nih.gov/42044161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42281331,ClpP Ensures Mitochondrial Integrity and Spermatocyte Meiotic Progression in Mice.,2026,10.1111/andr.70274,https://pubmed.ncbi.nlm.nih.gov/42281331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42655818,PTD-FNK Alleviated Heat Stress-Induced Apoptosis of Boar Sertoli Cells via the PI3K/AKT Pathway.,2026,10.3390/vetsci13080798,https://pubmed.ncbi.nlm.nih.gov/42655818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42377386,Overexpression of the BRC repeat 8 of BRCA2 hyperstabilizes RAD51 and alters DNA repair dynamics.,2026,10.1007/s11033-026-12238-3,https://pubmed.ncbi.nlm.nih.gov/42377386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42923200,Wrap53-1α and Wrap53-1β exert distinct p53-dependent effects on radiosensitivity in lung adenocarcinoma. ,2026,10.62347/jtrw8729,https://pubmed.ncbi.nlm.nih.gov/42923200/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42899482,Tumour Antigen-Specific Antibody Signatures as Diagnostic Biomarkers for Melanoma.,2026,10.1002/ijc.70726,https://pubmed.ncbi.nlm.nih.gov/42899482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42491125,Modelling DMC1 mediated homologous recombination repair in mouse embryonic stem cells.,2026,10.3389/fcell.2026.1744837,https://pubmed.ncbi.nlm.nih.gov/42491125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42827478,USP26-mediated stabilization of RAD51 promotes endometrial cancer progression and limits ferroptosis.,2026,10.3389/fonc.2026.1896160,https://pubmed.ncbi.nlm.nih.gov/42827478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42323478,SPOP-mediated nuclear ubiquitination degradation of p62/SQSTM1 contributes to HR repair.,2026,10.1038/s41388-026-03856-z,https://pubmed.ncbi.nlm.nih.gov/42323478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,40565326,Full-Length Transcriptome of Testis and Ovary Provides Insights into Alternative Splicing During Gonadal Development in &lt;i&gt;Litopenaeus vannamei&lt;/i&gt;.,2025,10.3390/ijms26125863,https://pubmed.ncbi.nlm.nih.gov/40565326/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,41569203,The Genetic Polymorphisms of DNA Repair Gene RAD51 and Their Role as a Predictive Biomarker for Breast Cancer Risk and Response to Radiotherapy in Iraqi Women.,2026,10.31557/apjcp.2026.27.1.345,https://pubmed.ncbi.nlm.nih.gov/41569203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42417500,PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer.,2026,10.1002/advs.76439,https://pubmed.ncbi.nlm.nih.gov/42417500/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42641219,RAD51 Predicts Poor Prognosis and Serves as a Therapeutic Target in Intrahepatic Cholangiocarcinoma.,2026,10.1016/j.jss.2026.07.053,https://pubmed.ncbi.nlm.nih.gov/42641219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42457656,Selective killing of ALT-cancer cells by Withaferin-A involves destabilization of Rad51 and disruption of DNA repair.,2026,10.1038/s41419-026-09115-z,https://pubmed.ncbi.nlm.nih.gov/42457656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42558868,Rewired DDR-TGF-β-β-catenin-PD-L1 axis accelerates progression and shapes therapy in human papillomavirus-driven cancer.,2026,10.3389/fimmu.2026.1907171,https://pubmed.ncbi.nlm.nih.gov/42558868/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42451670,Overcoming Resistance in Triple-Negative Breast Cancer: A Translational Perspective on Next-Generation DNA Damage Response Inhibitors and Synthetic Lethality.,2026,10.3390/molecules31132303,https://pubmed.ncbi.nlm.nih.gov/42451670/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,41984951,Multiomics profiling and experiments in preclinical models revealed RAD51-IN-1 as a synergistic potentiator of anlotinib sensitivity.,2026,10.1126/sciadv.aeb0855,https://pubmed.ncbi.nlm.nih.gov/41984951/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42794557,"Sensitizing Colorectal Cancer to PARP Inhibitors: Biomarkers, Mechanisms, and Combination Strategies.",2026,10.3390/ijms27188127,https://pubmed.ncbi.nlm.nih.gov/42794557/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42866954,Distinct ways by which Srs2 helicase and Rrp1 translocase shape Rad51-DNA interactions in fission yeast.,2026,10.1093/nar/gkag978,https://pubmed.ncbi.nlm.nih.gov/42866954/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42721822,Artesunate potentiates poly (ADP-ribose) polymerase inhibitor efficacy in ovarian cancer through RAD51-mediated homologous recombination repair impairment.,2026,10.1016/j.phymed.2026.158420,https://pubmed.ncbi.nlm.nih.gov/42721822/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,41900841,Interplay Between Poly(ADP-ribosyl)ation and Specific Inner Cellular Events That Suggest Combination Strategies for Overcoming PARP Inhibitor Resistance.,2026,10.3390/pharmaceutics18030355,https://pubmed.ncbi.nlm.nih.gov/41900841/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42274517,BRCA1/2 Reversion Mutations and Cancer Therapy Resistance.,2026,10.3390/biology15110866,https://pubmed.ncbi.nlm.nih.gov/42274517/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,41519649,"Subsequent-line Systemic Therapy for Metastatic or Recurrent Penile Cancer: A Systematic Review of Efficacy, Toxicity, and Outcomes.",2026,10.1016/j.euf.2025.12.016,https://pubmed.ncbi.nlm.nih.gov/41519649/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42643946,Rad51 strand invasion function is needed for its role in CCTG tetranucleotide DNA repeat contractions.,2026,10.17912/micropub.biology.002241,https://pubmed.ncbi.nlm.nih.gov/42643946/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42336814,EFHD2 drives lactate-mediated DNA damage repair and immunosuppression via HMGB1 and HIF-1α to confer radioresistance in colorectal cancer.,2026,10.1038/s41419-026-09031-2,https://pubmed.ncbi.nlm.nih.gov/42336814/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42303828,KPT-330-mediated XPO1 inhibition impairs homologous recombination and enhances radiosensitivity in extranodal NK/T-cell lymphoma.,2026,10.1038/s41416-026-03492-0,https://pubmed.ncbi.nlm.nih.gov/42303828/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,41420694,The role of homologous recombination in human retrovirus-associated diseases.,2026,10.1007/s11262-025-02210-x,https://pubmed.ncbi.nlm.nih.gov/41420694/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42582384,Risk stratification and multi-omics reveal RAD51 inhibition as a radiosensitizing strategy in triple-negative breast cancer.,2026,10.3389/fimmu.2026.1866358,https://pubmed.ncbi.nlm.nih.gov/42582384/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,40973024,PARP inhibitors in gastric cancer: unlocking precision oncology.,2025,10.1093/oncolo/oyaf283,https://pubmed.ncbi.nlm.nih.gov/40973024/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42125691,Progress in molecular markers associated with radiotherapy efficacy in glioma.,2026,10.3389/fonc.2026.1734404,https://pubmed.ncbi.nlm.nih.gov/42125691/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,42396657,Identification of RRM2 as a key regulator of malignant epithelial cells in gastric cancer through single‑cell transcriptomics.,2026,10.3892/or.2026.9159,https://pubmed.ncbi.nlm.nih.gov/42396657/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,41786739,RAD51-based homologous recombination deficiency is associated with treatment response and survival in early breast cancer.,2026,10.1038/s41523-026-00920-5,https://pubmed.ncbi.nlm.nih.gov/41786739/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51,ENSG00000051180,Unsafe,18417535,Identification of a novel human Rad51 variant that promotes DNA strand exchange.,2008,10.1093/nar/gkn171,https://pubmed.ncbi.nlm.nih.gov/18417535/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,42314057,PARG Governs a PARylation-Ubiquitination Toggle that Stabilizes RAD51AP1 to Drive Homologous Recombination-Mediated Chemoresistance.,2026,10.1158/0008-5472.can-25-4984,https://pubmed.ncbi.nlm.nih.gov/42314057/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,42729436,RAD51AP1-MYC-Sam68 positive transcriptional feedback loop maintains lung cancer stemness.,2026,10.1016/j.isci.2026.117397,https://pubmed.ncbi.nlm.nih.gov/42729436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,42595540,[Screening of mRNA molecules targeted by RAD51AP1 protein in human lung adenocarcinoma A549 cells and its effect on cell proliferation and apoptosis].,2026,10.3760/cma.j.cn112150-20251202-01136,https://pubmed.ncbi.nlm.nih.gov/42595540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,42697930,ITGA5 promotes homologous recombination mediated radioresistance in esophageal squamous cell carcinoma by upregulating RAD51AP1 expression.,2026,10.1038/s41388-026-03966-8,https://pubmed.ncbi.nlm.nih.gov/42697930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,41534830,Phosphoregulation of RAD51AP1 function in homology-directed repair.,2026,10.1016/j.jbc.2026.111149,https://pubmed.ncbi.nlm.nih.gov/41534830/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,42002087,DLGAP5 protects glioblastoma cells against DNA damage through E2F1-transcripted RAD51AP1.,2026,10.1016/j.bbadis.2026.168265,https://pubmed.ncbi.nlm.nih.gov/42002087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,41109978,Research Progress of RAD51AP1 in Malignant Tumors of the Female Reproductive System.,2025,10.1096/fj.202502048r,https://pubmed.ncbi.nlm.nih.gov/41109978/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,40495122,Transcriptomic analysis of laser-capture microdissected tumors reveals RAD51AP1 as a tumor-specific marker associated progression from pancreatic intraepithelial neoplasia to invasive pancreatic cancer.,2025,10.1186/s12935-025-03810-1,https://pubmed.ncbi.nlm.nih.gov/40495122/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,41337480,RAD51AP1 is a versatile RAD51 modulator.,2025,10.1073/pnas.2514728122,https://pubmed.ncbi.nlm.nih.gov/41337480/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,40211735,Epigenetically elevated RAD51AP1 regulates the RAD51-UAF1 complex contributing to temozolomide resistance in EGFRvIII glioblastoma.,2026,10.1097/cm9.0000000000003567,https://pubmed.ncbi.nlm.nih.gov/40211735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,42436803,PROTAC-based nanoassemblies targeting BRD4 for potentiate FLASH radiosensitization therapy.,2026,10.1016/j.mtbio.2026.103422,https://pubmed.ncbi.nlm.nih.gov/42436803/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,42630458,Functional phosphoproteomic analysis of SMG1 in nonsense-mediated mRNA decay and DNA damage repair in cancer.,2026,10.3389/fsysb.2026.1788470,https://pubmed.ncbi.nlm.nih.gov/42630458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,39235706,Knocking down RAD51AP1 enhances chemosensitivity by inhibiting the self-renewal of CD133 positive ovarian cancer stem-like cells.,2024,10.1007/s12672-024-01258-9,https://pubmed.ncbi.nlm.nih.gov/39235706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,41914496,TRF2-RAP1 inhibits homology-directed repair of telomeres by promoting BLM-mediated removal of telomere R-loops.,2026,10.1093/nar/gkag272,https://pubmed.ncbi.nlm.nih.gov/41914496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,41516135,Differentially Expressed Genes Associated with the Development of Cervical Cancer.,2025,10.3390/ijms27010258,https://pubmed.ncbi.nlm.nih.gov/41516135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,39850418,Identification of RAD51AP1 as a key gene in hepatitis B virus-associated hepatocellular carcinoma.,2025,10.1016/j.heliyon.2024.e41594,https://pubmed.ncbi.nlm.nih.gov/39850418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,41793192,Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G-Quadruplex Resolution to Maintain DNA Repair and Tumor Survival.,2026,10.1002/advs.202520798,https://pubmed.ncbi.nlm.nih.gov/41793192/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,39695160,RRM1 promotes homologous recombination and radio/chemo-sensitivity via enhancing USP11 and E2F1-mediated RAD51AP1 transcription.,2024,10.1038/s41420-024-02267-x,https://pubmed.ncbi.nlm.nih.gov/39695160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,37789880,RAD51AP1 as an Immune-Related Prognostic Biomarker and Therapeutic Response Predictor in Hepatocellular Carcinoma.,2023,10.2147/ijgm.s431206,https://pubmed.ncbi.nlm.nih.gov/37789880/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,38403248,Pre-rRNA facilitates the recruitment of RAD51AP1 to DNA double-strand breaks.,2024,10.1016/j.jbc.2024.107115,https://pubmed.ncbi.nlm.nih.gov/38403248/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,39528802,Discovery of key molecular signatures for diagnosis and therapies of glioblastoma by combining supervised and unsupervised learning approaches.,2024,10.1038/s41598-024-79391-2,https://pubmed.ncbi.nlm.nih.gov/39528802/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,41541703,Biochemical and Comparative Proteomic Analyses Delineate the Anti-Ovarian Carcinogenic Roles of Modified Calycosin.,2026,10.1002/fsn3.71338,https://pubmed.ncbi.nlm.nih.gov/41541703/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,39354765,A Risk Model Developed based on Homologous Recombination Deficiency Genes for Evaluating the Drug Sensitivity and Prognostic Prediction of Lung Adenocarcinoma.,2025,10.2174/0109298673333745240927074414,https://pubmed.ncbi.nlm.nih.gov/39354765/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,33314567,RAD51AP1 promotes progression of ovarian cancer via TGF-β/Smad signalling pathway.,2021,10.1111/jcmm.15877,https://pubmed.ncbi.nlm.nih.gov/33314567/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,36197550,Knockdown of RAD51AP1 suppressed cell proliferation and invasion in esophageal squamous cell carcinoma.,2022,10.1007/s12672-022-00566-2,https://pubmed.ncbi.nlm.nih.gov/36197550/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,35207688,Differential Expression of RAD51AP1 in Ovarian Cancer: Effects of siRNA In Vitro.,2022,10.3390/jpm12020201,https://pubmed.ncbi.nlm.nih.gov/35207688/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,35856434,METTL3 antagonizes 5‑FU chemotherapy and confers drug resistance in colorectal carcinoma.,2022,10.3892/ijo.2022.5396,https://pubmed.ncbi.nlm.nih.gov/35856434/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,35559013,Homologous Recombination Related Signatures Predict Prognosis and Immunotherapy Response in Metastatic Urothelial Carcinoma.,2022,10.3389/fgene.2022.875128,https://pubmed.ncbi.nlm.nih.gov/35559013/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,37461802,Life span-associated ferroptosis-related genes identification and validation for hepatocellular carcinoma patients as hepatitis B virus carriers.,2023,10.1002/jcla.24930,https://pubmed.ncbi.nlm.nih.gov/37461802/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,39038850,SUMO promotes DNA repair protein collaboration to support alternative telomere lengthening in the absence of PML.,2024,10.1101/gad.351667.124,https://pubmed.ncbi.nlm.nih.gov/39038850/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,33172895,"A Novel Neoplastic Fusion Transcript, RAD51AP1-DYRK4, Confers Sensitivity to the MEK Inhibitor Trametinib in Aggressive Breast Cancers.",2021,10.1158/1078-0432.ccr-20-2769,https://pubmed.ncbi.nlm.nih.gov/33172895/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,33403046,Six Novel Biomarkers for Diagnosis and Prognosis of Esophageal squamous cell carcinoma: validated by scRNA-seq and qPCR.,2021,10.7150/jca.50443,https://pubmed.ncbi.nlm.nih.gov/33403046/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51AP1,ENSG00000111247,Unsafe,9396801,A novel nucleic acid-binding protein that interacts with human rad51 recombinase.,1997,10.1093/nar/25.24.4946,https://pubmed.ncbi.nlm.nih.gov/9396801/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,42774970,Isocitrate Dehydrogenase (IDH)-Wildtype Glioblastoma With an Unusual EWSR1::RAD51B Gene Fusion: A Case Report and Review of the Literature.,2026,10.7759/cureus.115029,https://pubmed.ncbi.nlm.nih.gov/42774970/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,42137604,Low dose systemic AAV-exendin-4 gene therapy for Prader-Willi syndrome and dietary obesity.,2026,10.1016/j.omta.2026.201718,https://pubmed.ncbi.nlm.nih.gov/42137604/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,41318657,RAD51B-EZH2 axis as a potential therapeutic target for TNBC through cell fate conversion.,2025,10.1038/s41419-025-08259-8,https://pubmed.ncbi.nlm.nih.gov/41318657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,40584572,Dose-finding and &lt;i&gt;in vivo&lt;/i&gt; safety study of an adipose targeted leptin gene therapy for congenital leptin deficiency.,2025,10.1016/j.omtm.2025.101500,https://pubmed.ncbi.nlm.nih.gov/40584572/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,42914689,Bizarre But Benign: A Case Report of an EHHADH::RAD51B Rearranged Endometrial Polyp With Bizarre Stromal Cells.,2026,10.1097/pgp.0000000000001222,https://pubmed.ncbi.nlm.nih.gov/42914689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,41225720,"Extrauterine RAD51B -Rearranged Soft Tissue Tumors : A Clinicopathologic and Molecular Genetic Study of 10 Cases With Heterogeneous Morphology, Novel Fusions, and a Distinct Methylation Profile.",2026,10.1097/pas.0000000000002485,https://pubmed.ncbi.nlm.nih.gov/41225720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,42908240,The Largest Cohort Study of Intravenous Leiomyomatosis Reveals HMGA2 and Collagen Gene Alterations as Cooperative Drivers.,2026,10.1097/pas.0000000000002637,https://pubmed.ncbi.nlm.nih.gov/42908240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,42442572,The lncRNA CTD-2566 J3.1 orchestrates oncogenic gene regulation via chromatin interactions in luminal breast cancer.,2026,10.1016/j.ijbiomac.2026.153508,https://pubmed.ncbi.nlm.nih.gov/42442572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,42133623,Cancer mutations in RAD51 and its paralogues.,2026,10.1371/journal.pone.0349105,https://pubmed.ncbi.nlm.nih.gov/42133623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,39094948,An efficient AAV vector system of Rec2 serotype for intravenous injection to study metabolism in brown adipocytes in vivo.,2024,10.1016/j.molmet.2024.101999,https://pubmed.ncbi.nlm.nih.gov/39094948/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,40360859,CD34-positive pleomorphic uterine sarcoma with NUDT3::RAD51B fusion.,2025,10.1007/s00428-025-04126-1,https://pubmed.ncbi.nlm.nih.gov/40360859/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,42329450,Investigating the shared genetic architecture between selective immunoglobulin A deficiency and autoimmune diseases.,2026,10.1007/s00439-026-02850-5,https://pubmed.ncbi.nlm.nih.gov/42329450/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,39398244,Development of an adipose-tropic AAV capsid ablating liver tropism.,2024,10.1016/j.isci.2024.110930,https://pubmed.ncbi.nlm.nih.gov/39398244/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,41617065,Chronic perfluorobutanoic acid (PFBA) exposure induces apoptosis and inflammation of gill in zebrafish (Danio rerio).,2026,10.1016/j.fsi.2026.111164,https://pubmed.ncbi.nlm.nih.gov/41617065/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,41137179,Genomic landscape of endometrial polyps.,2025,10.1186/s13073-025-01556-z,https://pubmed.ncbi.nlm.nih.gov/41137179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,41772053,BCDX2-CX3 and DX2-CX3 complexes assemble and stabilize RAD51 filaments.,2026,10.1038/s41586-026-10314-z,https://pubmed.ncbi.nlm.nih.gov/41772053/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,42206731,"Uterine Myxoid Inflammatory Myofibroblastic Sarcoma (MIMS) Harboring Pathogenic KRAS Mutations and Expressing ER, PR, and CD10.",2026,10.1097/pgp.0000000000001192,https://pubmed.ncbi.nlm.nih.gov/42206731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,42413182,"Impact of duration of cyclic heat stress exposure at different ages on growth performance, recovery, and histopathology in broilers.",2026,10.1016/j.psj.2026.107367,https://pubmed.ncbi.nlm.nih.gov/42413182/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,40439781,Bioprospecting potential genetic biomarkers of gallbladder cancer.,2025,10.1007/s11033-025-10607-y,https://pubmed.ncbi.nlm.nih.gov/40439781/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,41555274,"Rs12516 A allele elevates the risk of colorectal cancer via functional CeRNA network of BDNF-AS, miR-4704-5p and BRCA1.",2026,10.1186/s12885-025-14692-x,https://pubmed.ncbi.nlm.nih.gov/41555274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,41536763,Patterns of prostate recurrence after focal salvage prostate brachytherapy for radiorecurrent prostate cancer.,2026,10.1016/j.ctro.2025.101043,https://pubmed.ncbi.nlm.nih.gov/41536763/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,41099623,Olaparib for patients with tumors harboring alterations in homologous recombination repair genes: Results from the drug rediscovery protocol.,2026,10.1002/ijc.70191,https://pubmed.ncbi.nlm.nih.gov/41099623/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,40533854,"Homologous recombination-DNA damage response defects increase TMB and neoantigen load, but not effector T cell density and clonal diversity in pancreatic cancer.",2025,10.1186/s40164-025-00673-0,https://pubmed.ncbi.nlm.nih.gov/40533854/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,39640282,A phase II study evaluating safety and efficacy of niraparib in patients with previously treated homologous recombination defective metastatic esophageal/gastroesophageal junction/proximal gastric adenocarcinoma.,2024,10.3389/fonc.2024.1435056,https://pubmed.ncbi.nlm.nih.gov/39640282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,42392280,Impact of therapeutic hypothermia on oxygen demand and respiratory function in post-cardiac arrest patients: A retrospective cohort study.,2026,10.1016/j.rmed.2026.109012,https://pubmed.ncbi.nlm.nih.gov/42392280/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,42431822,"Real-world clinical outcomes, genetic testing patterns, and treatment patterns of patients with metastatic castration-resistant prostate cancer treated with olaparib monotherapy in the United States.",2026,10.1016/j.urolonc.2026.06.017,https://pubmed.ncbi.nlm.nih.gov/42431822/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,40632975,LODESTAR: A Single-Arm Phase II Study of Rucaparib in Solid Tumors With Pathogenic Germline or Somatic Variants in Homologous Recombination Repair Genes.,2025,10.1200/po-25-00090,https://pubmed.ncbi.nlm.nih.gov/40632975/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,42169974,Particulate Hexavalent Chromium Inhibits RAD51 Paralogs Necessary for RAD51 Filament Formation and Stabilization During Homologous Recombination Repair.,2026,10.3390/occuphealth1010013,https://pubmed.ncbi.nlm.nih.gov/42169974/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,42133897,Homozygous Loss of Recombination Repair Genes and Poly ADP-Ribose Polymerase Inhibitor Benefit for Patients With Ovarian Cancer.,2026,10.1200/po-25-00763,https://pubmed.ncbi.nlm.nih.gov/42133897/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,42651857,Genome-Wide Association Study and Genomic Selection for Average Daily Gain in Ashidan Yak.,2026,10.3390/ani16162452,https://pubmed.ncbi.nlm.nih.gov/42651857/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,40670332,Comprehensive RAD51C ovarian cancer variant analysis uncouples homologous recombination and replicative functions.,2025,10.1038/s41467-025-61283-2,https://pubmed.ncbi.nlm.nih.gov/40670332/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,39774105,DNA targeting by compact Cas9d and its resurrected ancestor.,2025,10.1038/s41467-024-55573-4,https://pubmed.ncbi.nlm.nih.gov/39774105/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,37286545,Integrated multi-omics analyses reveal homology-directed repair pathway as a unique dependency in near-haploid leukemia.,2023,10.1038/s41408-023-00863-1,https://pubmed.ncbi.nlm.nih.gov/37286545/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD51B,ENSG00000182185,Unsafe,35735442,A Case Study of Clinical Response to Rucaparib in a Patient with Metastatic Castration-Resistant Prostate Cancer and a RAD51B Alteration.,2022,10.3390/curroncol29060333,https://pubmed.ncbi.nlm.nih.gov/35735442/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,41606132,RAD54B as a biomarker for prognosis and immunotherapy response in bladder cancer.,2026,10.1007/s12672-026-04514-2,https://pubmed.ncbi.nlm.nih.gov/41606132/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,42193784,Transcriptomic and Ultrastructural Analyses Reveal the Mechanisms of Accelerated Depuration Induced by &lt;i&gt;Phyllodium pulchellum&lt;/i&gt; Extract in the Freshwater Snail &lt;i&gt;Bellamya purificata&lt;/i&gt;.,2026,10.3390/ani16101490,https://pubmed.ncbi.nlm.nih.gov/42193784/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,40841926,Synergistic effects of Bifidobacterium longum subsp. infantis B8762 and milk-derived osteopontin on male reproductive health in mice.,2025,10.1002/jsfa.70121,https://pubmed.ncbi.nlm.nih.gov/40841926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,41591910,Integrated mutational landscape analysis of endometrial stromal sarcoma.,2026,10.1073/pnas.2531105123,https://pubmed.ncbi.nlm.nih.gov/41591910/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,42018084,Translating Host-Derived Signals from Cerebrospinal Fluid Metagenomic Sequencing into a Diagnostic Tool for Autoimmune Encephalitis in Children.,2026,10.1007/s10875-026-02023-z,https://pubmed.ncbi.nlm.nih.gov/42018084/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,41255412,Prognostic and Immunological Implications of Telomere Maintenance-Related Genes in Breast Cancer: A Mechanistic Exploration.,2025,10.2147/bctt.s545745,https://pubmed.ncbi.nlm.nih.gov/41255412/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,42349107,Fusion gene heterogeneity and kinase enrichment in high-grade serous carcinomas.,2026,10.1016/j.neo.2026.101332,https://pubmed.ncbi.nlm.nih.gov/42349107/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,41249704,Integrated machine learning and single-cell analysis identify chromatin-remodeling gene signature for diagnosis and prognosis in nasopharyngeal carcinoma.,2025,10.1007/s10238-025-01953-z,https://pubmed.ncbi.nlm.nih.gov/41249704/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,41567021,Integrated transcriptomic and proteomic analysis reveals the mechanistic role of OST in cutaneous squamous cell carcinoma.,2025,10.4149/neo_2025_250422n178,https://pubmed.ncbi.nlm.nih.gov/41567021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,40387455,AP1M2 Drives Gemcitabine-Cisplatin Chemoresistance by Enhancing RAD54B-Associated DNA Repair in Bladder Cancer.,2025,10.1096/fj.202500423r,https://pubmed.ncbi.nlm.nih.gov/40387455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,41457145,hsa-miR-145-3p defines a fibro-inflammatory bladder cancer subtype with distinct therapeutic vulnerabilities.,2025,10.1007/s12672-025-04355-5,https://pubmed.ncbi.nlm.nih.gov/41457145/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,42196471,Construction of a Lysine Lactylation- and DNA Damage Repair-Related Gene Signature to Predict the Prognosis and Drug Sensitivity of Breast Cancer Patients.,2026,10.3390/ijms27104493,https://pubmed.ncbi.nlm.nih.gov/42196471/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,39795882,Novel FANCI and RAD54B Variants and the Observed Clinical Outcomes in a Hungarian Melanoma Cohort.,2024,10.3390/ijms26010023,https://pubmed.ncbi.nlm.nih.gov/39795882/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,38378037,RAD54B promotes gastric cancer cell migration and angiogenesis via the Wnt/β-catenin pathway.,2024,10.2478/raon-2024-0007,https://pubmed.ncbi.nlm.nih.gov/38378037/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,40290304,Metastatic pheochromocytoma complicated with Langerhans cell histiocytosis: a case report.,2025,10.3389/fendo.2025.1494783,https://pubmed.ncbi.nlm.nih.gov/40290304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,42292383,From molecular networks to translational intervention: current progress in the mechanisms of gemcitabine resistance in bladder cancer.,2026,10.3389/fimmu.2026.1860957,https://pubmed.ncbi.nlm.nih.gov/42292383/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,37748205,RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway.,2024,10.1139/cjpp-2023-0192,https://pubmed.ncbi.nlm.nih.gov/37748205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,39934227,"Repeat expansion in a fragile X model is independent of double strand break repair mediated by Pol θ, RAD52, RAD54 or RAD54B.",2025,10.1038/s41598-025-87541-3,https://pubmed.ncbi.nlm.nih.gov/39934227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,35952757,RAD54B mutations enhance the sensitivity of ovarian cancer cells to poly(ADP-ribose) polymerase (PARP) inhibitors.,2022,10.1016/j.jbc.2022.102354,https://pubmed.ncbi.nlm.nih.gov/35952757/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,39529015,Identification of alternative lengthening of telomeres-related genes prognosis model in hepatocellular carcinoma.,2024,10.1186/s12885-024-13146-0,https://pubmed.ncbi.nlm.nih.gov/39529015/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,35847584,Identification of a Prognostic Transcriptome Signature for Hepatocellular Carcinoma with Lymph Node Metastasis.,2022,10.1155/2022/7291406,https://pubmed.ncbi.nlm.nih.gov/35847584/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,40344211,Genomic variant profiling in blast-phase paediatric chronic myeloid leukaemia: Predisposing and driving alterations.,2025,10.1111/bjh.20133,https://pubmed.ncbi.nlm.nih.gov/40344211/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,40373259,Phase II Study of Niraparib in Patients With Advanced Melanoma With Homologous Recombination Pathway Gene Mutations.,2025,10.1200/po-24-00658,https://pubmed.ncbi.nlm.nih.gov/40373259/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,34049150,Amplification of RAD54B promotes progression of hepatocellular carcinoma via activating the Wnt/β-catenin signaling.,2021,10.1016/j.tranon.2021.101124,https://pubmed.ncbi.nlm.nih.gov/34049150/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,37923899,DNA damage repair-related gene signature for identifying the immune status and predicting the prognosis of hepatocellular carcinoma.,2023,10.1038/s41598-023-45999-z,https://pubmed.ncbi.nlm.nih.gov/37923899/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,38735911,Prognostic significance and immune landscape of a cell cycle progression-related risk model in bladder cancer.,2024,10.1007/s12672-024-01008-x,https://pubmed.ncbi.nlm.nih.gov/38735911/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,38001987,Exploiting TLK1 and Cisplatin Synergy for Synthetic Lethality in Androgen-Insensitive Prostate Cancer.,2023,10.3390/biomedicines11112987,https://pubmed.ncbi.nlm.nih.gov/38001987/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,32354124,Are Pathogenic Germline Variants in Metastatic Melanoma Associated with Resistance to Combined Immunotherapy?,2020,10.3390/cancers12051101,https://pubmed.ncbi.nlm.nih.gov/32354124/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54B,ENSG00000197275,Unsafe,10362364,"Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer.",1999,10.1038/sj.onc.1202691,https://pubmed.ncbi.nlm.nih.gov/10362364/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,42774555,Whole-genome sequencing identifies a potentially causative homozygous splicing variant in &lt;i&gt;RAD54&lt;/i&gt; like in non-obstructive azoospermia.,2026,10.18502/ijrm.v24i7.21585,https://pubmed.ncbi.nlm.nih.gov/42774555/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,42399962,NSUN2-mediated m5C modification of E2F1 promotes lung adenocarcinoma progression via the RAD54L signaling axis.,2026,10.1186/s12931-026-03757-5,https://pubmed.ncbi.nlm.nih.gov/42399962/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,42493648,RAD54L coordinates the nucleolar DNA damage response to maintain rDNA stability.,2026,10.1038/s44318-026-00864-3,https://pubmed.ncbi.nlm.nih.gov/42493648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,41535248,SOHLH2-RAD54L axis induces radioresistance by promoting homologous recombination repair in non-small cell lung cancer.,2026,10.1038/s41420-025-02924-9,https://pubmed.ncbi.nlm.nih.gov/41535248/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,42793752,&lt;i&gt;MCPH1&lt;/i&gt; and DNA Damage Response Pathway Genes as Candidate Susceptibility Loci in Hereditary Breast Cancer.,2026,10.3390/diagnostics16182967,https://pubmed.ncbi.nlm.nih.gov/42793752/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,40730084,Porcine reproductive and respiratory syndrome virus downregulates the circ-107191/miR-34c/RAD54L axis to promote testicular cell apoptosis via impaired homologous recombination repair.,2025,10.1016/j.theriogenology.2025.117606,https://pubmed.ncbi.nlm.nih.gov/40730084/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,40616532,RAD54L Is a Prognostic Biomarker and Demonstrate Correlation With Drug Sensitivity in Hepatocellular Carcinoma.,2025,10.1002/cbin.70054,https://pubmed.ncbi.nlm.nih.gov/40616532/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,42349107,Fusion gene heterogeneity and kinase enrichment in high-grade serous carcinomas.,2026,10.1016/j.neo.2026.101332,https://pubmed.ncbi.nlm.nih.gov/42349107/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,41079598,Comparative bioinformatics analysis of the Wnt pathway in breast cancer: Selection of novel biomarker panels associated with ER status.,2025,10.1515/biol-2025-1173,https://pubmed.ncbi.nlm.nih.gov/41079598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,42215586,Ethnicity-specific molecular subtypes and a machine-learning risk model in Asian patients with non-muscle-invasive bladder cancer.,2026,10.1038/s41598-026-55438-4,https://pubmed.ncbi.nlm.nih.gov/42215586/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,38593124,Overexpression of RAD54L attenuates osteoarthritis by suppressing the HIF-1α/VEGF signaling pathway: Bioinformatics analysis and experimental validation.,2024,10.1371/journal.pone.0298575,https://pubmed.ncbi.nlm.nih.gov/38593124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,37719938,Pan-Cancer Analysis of Oncogenic Role of RAD54L and Experimental Validation in Hepatocellular Carcinoma.,2023,10.2147/jir.s426558,https://pubmed.ncbi.nlm.nih.gov/37719938/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,39315725,Disparate requirements for RAD54L in replication fork reversal.,2024,10.1093/nar/gkae828,https://pubmed.ncbi.nlm.nih.gov/39315725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,41926491,Identification of circRNA/lncRNA-miRNA-Transcription Factor-mRNA Networks to Identify Potential Biomarkers in Response to Neoadjuvant Therapy for Breast Cancer.,2026,10.2147/bctt.s538948,https://pubmed.ncbi.nlm.nih.gov/41926491/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,41088366,Exome sequencing reveals new insights into the germline landscape of inflammatory breast cancer among Tunisian patients.,2025,10.1186/s12967-025-07027-8,https://pubmed.ncbi.nlm.nih.gov/41088366/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,42725434,The dynamics of RAD51 foci formation and elongation in living human cells.,2026,10.1093/nar/gkag863,https://pubmed.ncbi.nlm.nih.gov/42725434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,41064634,Integrated analysis and experimental validation of E2F2 as a potential prognostic biomarker and its oncogenic roles in serous ovarian cancer.,2025,10.3389/fmolb.2025.1661558,https://pubmed.ncbi.nlm.nih.gov/41064634/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,40321702,Gene co-expression network analysis reveals relationship between leukocyte fraction and genomic instability in dedifferentiated liposarcoma.,2025,10.22099/mbrc.2025.51329.2050,https://pubmed.ncbi.nlm.nih.gov/40321702/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,41587107,Evolution of AR and Non-AR Alterations in ctDNA of Patients with Metastatic Prostate Cancer Treated in the Phase III Alliance A031201 Trial.,2026,10.1158/1078-0432.ccr-25-2779,https://pubmed.ncbi.nlm.nih.gov/41587107/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,36454390,DNA repair/recombination protein 54L promotes the progression of lung adenocarcinoma by activating mTORC1 pathway.,2023,10.1007/s13577-022-00832-z,https://pubmed.ncbi.nlm.nih.gov/36454390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,41185726,A Case of Metastatic Castration-Resistant Prostate Cancer With &lt;i&gt;RAD54L&lt;/i&gt; Mutation Responding to Niraparib.,2025,10.1002/iju5.70093,https://pubmed.ncbi.nlm.nih.gov/41185726/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,39640282,A phase II study evaluating safety and efficacy of niraparib in patients with previously treated homologous recombination defective metastatic esophageal/gastroesophageal junction/proximal gastric adenocarcinoma.,2024,10.3389/fonc.2024.1435056,https://pubmed.ncbi.nlm.nih.gov/39640282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,40227503,Clinical Outcomes and Genomic Alterations in Gleason Score 10 Prostate Cancer.,2025,10.3390/cancers17071055,https://pubmed.ncbi.nlm.nih.gov/40227503/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,42431822,"Real-world clinical outcomes, genetic testing patterns, and treatment patterns of patients with metastatic castration-resistant prostate cancer treated with olaparib monotherapy in the United States.",2026,10.1016/j.urolonc.2026.06.017,https://pubmed.ncbi.nlm.nih.gov/42431822/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,40665355,Bioinformatics analysis and experimental studies reveal KPNA2 as a novel biomarker of hepatocellular carcinoma progression and telomere maintenance.,2025,10.1186/s40001-025-02866-z,https://pubmed.ncbi.nlm.nih.gov/40665355/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,38617927,Characterization of a G2M checkpoint-related gene model and subtypes associated with immunotherapy response for clear cell renal cell carcinoma.,2024,10.1016/j.heliyon.2024.e29289,https://pubmed.ncbi.nlm.nih.gov/38617927/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,41662332,Ultrarare Variants in DNA Damage Repair and Mitochondrial Genes in Pediatric Acute-Onset Neuropsychiatric Syndrome and Acute Behavioral Regression in Neurodevelopmental Disorders.,2026,10.1159/000550301,https://pubmed.ncbi.nlm.nih.gov/41662332/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,38720017,Modification Effects of Homologous Recombination Repair Gene Polymorphisms on the Associations Between Urinary Metals and Breast Cancer Risk.,2025,10.1007/s12011-024-04215-3,https://pubmed.ncbi.nlm.nih.gov/38720017/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,40420266,Pan-cancer analysis of homologous recombination deficiency and homologous recombination repair-associated gene alterations in solid tumors from a large Asian cohort.,2025,10.1186/s12885-025-14267-w,https://pubmed.ncbi.nlm.nih.gov/40420266/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,38948477,Case report: Remarkable response to later-line surufatinib in an adult patient with liver metastatic of pancreatoblastoma.,2024,10.3389/fphar.2024.1361628,https://pubmed.ncbi.nlm.nih.gov/38948477/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD54L,ENSG00000085999,Unsafe,40166687,The Clinical Pathological Characteristics and Prognostic Relevance of Homologous Recombination Repair Gene Mutations in Ovarian Cancer Patients: A Prospective Cohort Study.,2025,10.1155/ogi/5578247,https://pubmed.ncbi.nlm.nih.gov/40166687/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD9B,ENSG00000151164,Unsafe,37460044,Expression of RAD9B in the mesostriatal system of rats and humans: Overexpression in a 6-OHDA rat model of Parkinson's disease.,2023,10.1016/j.aanat.2023.152135,https://pubmed.ncbi.nlm.nih.gov/37460044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD9B,ENSG00000151164,Unsafe,39488637,TGF-β superfamily-induced transcriptional activation pathways establish the RAD52-dependent ALT machinery during malignant transformation of MPNSTs.,2024,10.1038/s41598-024-76732-z,https://pubmed.ncbi.nlm.nih.gov/39488637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD9B,ENSG00000151164,Unsafe,35133274,"Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis.",2022,10.7554/elife.68677,https://pubmed.ncbi.nlm.nih.gov/35133274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD9B,ENSG00000151164,Unsafe,31898828,Loss of RAD9B impairs early neural development and contributes to the risk for human spina bifida.,2020,10.1002/humu.23969,https://pubmed.ncbi.nlm.nih.gov/31898828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD9B,ENSG00000151164,Unsafe,39317954,NEDD4L affects KLF5 stability through ubiquitination to control ferroptosis and radiotherapy resistance in oesophageal squamous cell carcinoma.,2024,10.1111/jcmm.70062,https://pubmed.ncbi.nlm.nih.gov/39317954/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD9B,ENSG00000151164,Unsafe,31164693,Monozygotic twins and triplets discordant for amyotrophic lateral sclerosis display differential methylation and gene expression.,2019,10.1038/s41598-019-44765-4,https://pubmed.ncbi.nlm.nih.gov/31164693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD9B,ENSG00000151164,Unsafe,20842695,Mouse Rad9b is essential for embryonic development and promotes resistance to DNA damage.,2010,10.1002/dvdy.22415,https://pubmed.ncbi.nlm.nih.gov/20842695/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD9B,ENSG00000151164,Unsafe,29194591,A mutational comparison of adult and adolescent and young adult (AYA) colon cancer.,2018,10.1002/cncr.31136,https://pubmed.ncbi.nlm.nih.gov/29194591/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD9B,ENSG00000151164,Unsafe,24013428,Clamping down on mammalian meiosis.,2013,10.4161/cc.26061,https://pubmed.ncbi.nlm.nih.gov/24013428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD9B,ENSG00000151164,Unsafe,14611806,"Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene.",2003,10.1016/s0888-7543(03)00200-3,https://pubmed.ncbi.nlm.nih.gov/14611806/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD9B,ENSG00000151164,Unsafe,23750556,"Up-regulation of endothelial nitric oxide synthase (eNOS), silent mating type information regulation 2 homologue 1 (SIRT1) and autophagy-related genes by repeated treatments with resveratrol in human umbilical vein endothelial cells.",2013,10.1017/s0007114513001670,https://pubmed.ncbi.nlm.nih.gov/23750556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD9B,ENSG00000151164,Unsafe,20081369,The Rad9A checkpoint protein is required for nuclear localization of the claspin adaptor protein.,2010,10.4161/cc.9.3.10553,https://pubmed.ncbi.nlm.nih.gov/20081369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAD9B,ENSG00000151164,Unsafe,14500360,Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue.,2003,,https://pubmed.ncbi.nlm.nih.gov/14500360/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,42854990,Thymic stromal defects and immune dysregulation in hypomorphic Rag deficiency: implications for hematopoietic cell transplantation.,2026,10.1016/j.jaci.2026.09.023,https://pubmed.ncbi.nlm.nih.gov/42854990/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,42549314,RAG1 deficiency durably alters dermal group 2 innate lymphoid cells and modifies contact hypersensitivity.,2026,10.3389/fimmu.2026.1859649,https://pubmed.ncbi.nlm.nih.gov/42549314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,42006326,RAG1-independent atypical B cell development in chickens: Redefining the role of &lt;i&gt;RAG1&lt;/i&gt; in avian immunology.,2026,10.1016/j.isci.2026.115472,https://pubmed.ncbi.nlm.nih.gov/42006326/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,41927530,Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in male mice.,2026,10.1038/s41467-026-70469-1,https://pubmed.ncbi.nlm.nih.gov/41927530/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,42314684,ABO: A 3D stroma-supported culture platform enabling full human B-lymphopoiesis for disease modeling and gene therapy development.,2026,10.1016/j.xcrm.2026.102879,https://pubmed.ncbi.nlm.nih.gov/42314684/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,41538412,Germline Homozygous RAG1 Missense Variant Associated With Epstein-Barr Virus Negative Childhood Burkitt Lymphoma: A Case Report.,2026,10.1097/mph.0000000000003159,https://pubmed.ncbi.nlm.nih.gov/41538412/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,40829114,RAG1 lentiviral gene therapy restores T-cell development of RAG1-SCID patient cells in artificial thymic organoids.,2025,10.1182/bloodadvances.2025016970,https://pubmed.ncbi.nlm.nih.gov/40829114/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,42845884,Physiological upregulation of RAG1 expression compromises the survival of CD4&lt;sup&gt;+&lt;/sup&gt;CD8&lt;sup&gt;+&lt;/sup&gt; thymocytes &lt;i&gt;in vitro&lt;/i&gt;.,2026,10.3389/fimmu.2026.1849780,https://pubmed.ncbi.nlm.nih.gov/42845884/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,42911305,Early-Onset Autoimmune Cytopenias and Progressive Immunodeficiency in a Child with a Homozygous RAG1 p.Asn803Ser Variant: A Case Report.,2026,10.1007/s10875-026-02086-y,https://pubmed.ncbi.nlm.nih.gov/42911305/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,41615805,"PD-L1 is an intrinsic switch for natural killer cell-mediated, TRAIL-dependent antiviral function.",2026,10.1016/j.celrep.2026.116939,https://pubmed.ncbi.nlm.nih.gov/41615805/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,42757551,Impact of Reference Gene Choice on Accurate Gene Expression Analysis Under Emerging Contaminant Exposure.,2026,10.1002/tox.70198,https://pubmed.ncbi.nlm.nih.gov/42757551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,42841665,Application of IgA-Seq in schizophrenia to identify key gut bacteria that promote abnormal behavior in mice.,2026,10.1128/msystems.00786-26,https://pubmed.ncbi.nlm.nih.gov/42841665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,42533592,Rag1-based time-stamp tracing of T-cell developmental origins.,2026,10.1093/jimmun/vkag154,https://pubmed.ncbi.nlm.nih.gov/42533592/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,42744390,LRIG2 suppresses NK cell-induced GSDME-mediated pyroptosis via the LAMP1-STAT3 pathway in glioma.,2026,10.1136/jitc-2026-015730,https://pubmed.ncbi.nlm.nih.gov/42744390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,41958681,Evolutionary insights and structural characterization guide the development of RAG1/RAG2-deficient swine models for immunological research.,2026,10.3389/fimmu.2026.1757508,https://pubmed.ncbi.nlm.nih.gov/41958681/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,42120609,Optics-free spatial genomics for mapping mammalian brain aging by IRISeq.,2026,10.1038/s41593-026-02293-1,https://pubmed.ncbi.nlm.nih.gov/42120609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,42099611,Case report: Persistent hypogammaglobulinemia following hematopoietic stem cell transplantation from a sibling donor with heterozygous RAG1 mutation.,2026,10.3389/fimmu.2026.1798445,https://pubmed.ncbi.nlm.nih.gov/42099611/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,42727428,Inflammatory plasma transfer induces early ovarian CD8&lt;sup&gt;+&lt;/sup&gt; accumulation without overt pathology.,2026,10.1016/j.jri.2026.104962,https://pubmed.ncbi.nlm.nih.gov/42727428/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,40849887,RACK1 is required for normal B cell development and signaling but not RAG1 degradation.,2025,10.1093/jimmun/vkaf217,https://pubmed.ncbi.nlm.nih.gov/40849887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,42118412,From PGT-M discovery to mechanism: functional validation of novel compound heterozygous RAG1 mutations in severe combined immunodeficiency.,2026,10.1007/s10815-026-03887-1,https://pubmed.ncbi.nlm.nih.gov/42118412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,42099231,Applications of humanized mice in &lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt; infections (Review).,2026,10.3892/mmr.2026.13898,https://pubmed.ncbi.nlm.nih.gov/42099231/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,42861590,Anemoside B4 from &lt;i&gt;Pulsatilla chinensis&lt;/i&gt; Ameliorates Ulcerative Colitis by Inhibiting Inflammatory Responses via the Modulation of the Gut Microbiota-Immune Interplay.,2026,10.1142/s0192415x26500849,https://pubmed.ncbi.nlm.nih.gov/42861590/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,40107272,Safety and efficacy of gene therapy for RAG1-deficient SCID.,2025,10.1016/j.ymthe.2025.02.044,https://pubmed.ncbi.nlm.nih.gov/40107272/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,42625375,The Thymic Microenvironment Shapes Age-Related Qualitative Changes in the TCR Repertoire.,2026,10.1111/acel.70675,https://pubmed.ncbi.nlm.nih.gov/42625375/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,41601259,Proximity-based proteomic profiling uncovers distinct interactome of human RAG1 and RAG2.,2026,10.3724/abbs.2025246,https://pubmed.ncbi.nlm.nih.gov/41601259/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,41902554,An Update on Inborn Errors of V(D)J Recombination.,2026,10.1152/physiol.00004.2026,https://pubmed.ncbi.nlm.nih.gov/41902554/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG1,ENSG00000166349,Unsafe,42529228,Single-cell transcriptomic profiling of bronchial lymph nodes reveals mechanisms of PRRSV escape from host adaptive immunity.,2026,10.3389/fimmu.2026.1869357,https://pubmed.ncbi.nlm.nih.gov/42529228/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,42230577,"An antagonistically pleiotropic gene regulates vertebrate growth, maturity, and lifespan.",2026,10.1038/s41467-026-72381-0,https://pubmed.ncbi.nlm.nih.gov/42230577/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,42081929,uPAR exhibits age- and region-dependent expression in the brains of mice with Alzheimer's disease-like pathology.,2026,10.1016/j.brainres.2026.150364,https://pubmed.ncbi.nlm.nih.gov/42081929/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,42554806,Differential impact of lymphocytes on radiation response in autochthonous vs transplant murine sarcomas.,2026,10.1093/jnci/djag261,https://pubmed.ncbi.nlm.nih.gov/42554806/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,41898554,Evidence for Autoimmunity in the Pathogenesis of COVID-19-Induced Myocarditis.,2026,10.3390/ijms27062694,https://pubmed.ncbi.nlm.nih.gov/41898554/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,42289615,Transgenic expression of human signal regulatory protein alpha (SIRPα) in BALB/c Rag2&lt;sup&gt;null&lt;/sup&gt;/Jak3&lt;sup&gt;null&lt;/sup&gt; immunodeficient mice enhances human lymphoma xenografts by reducing phagocytosis.,2026,10.1007/s11248-026-00500-0,https://pubmed.ncbi.nlm.nih.gov/42289615/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,41968583,Restoration of the immune system with base editing and non-genotoxic conditioning in a Rag2 point-mutant mouse model.,2026,10.1016/j.ymthe.2026.04.010,https://pubmed.ncbi.nlm.nih.gov/41968583/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,41890729,Midgestational injection of highly expanded human CD34+ cells increases lineages of human immune cells and supports thymic development in &lt;i&gt;RAG2-/-IL2RG-/Y&lt;/i&gt; SCID pigs.,2026,10.3389/fimmu.2026.1751541,https://pubmed.ncbi.nlm.nih.gov/41890729/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,41958681,Evolutionary insights and structural characterization guide the development of RAG1/RAG2-deficient swine models for immunological research.,2026,10.3389/fimmu.2026.1757508,https://pubmed.ncbi.nlm.nih.gov/41958681/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,40948793,ATP/P2X7 receptor signal aggravates ischemic stroke injury by activating Th17 cells via STAT3/IL-21 pathway.,2025,10.3389/fimmu.2025.1558307,https://pubmed.ncbi.nlm.nih.gov/40948793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,42209588,"Clinical and genetic landscape of SCID in Yunnan, China: identification of two novel RAG2 variants.",2026,10.1038/s41598-026-54172-1,https://pubmed.ncbi.nlm.nih.gov/42209588/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,41537706,Exploring the 89Zr/177Lu Theranostic Pairing with an Extracellular Matrix-Targeted Radiopharmaceutical against Triple-Negative Breast Cancer.,2026,10.1158/1078-0432.ccr-25-3354,https://pubmed.ncbi.nlm.nih.gov/41537706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,42687341,Androgen-associated remodeling of pulmonary NK cells and sex-biased susceptibility in lupus-associated diffuse alveolar hemorrhage.,2026,10.1080/08916934.2026.2722939,https://pubmed.ncbi.nlm.nih.gov/42687341/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,42611848,A Novel Scale Biopsy Method to Collect Zebrafish Malignant and Non-Malignant Lymphocytes.,2026,10.3791/72153,https://pubmed.ncbi.nlm.nih.gov/42611848/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,41826820,ICOS&lt;sup&gt;+&lt;/sup&gt; T helper 2 cells promote the pulmonary fibrosis in systemic sclerosis.,2026,10.1186/s10020-026-01455-y,https://pubmed.ncbi.nlm.nih.gov/41826820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,41557789,Functionally heterogeneous intratumoral CD4&lt;sup&gt;+&lt;/sup&gt;CD8&lt;sup&gt;+&lt;/sup&gt; double-positive T cells can give rise to single-positive T cells.,2026,10.1073/pnas.2506168123,https://pubmed.ncbi.nlm.nih.gov/41557789/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,41601259,Proximity-based proteomic profiling uncovers distinct interactome of human RAG1 and RAG2.,2026,10.3724/abbs.2025246,https://pubmed.ncbi.nlm.nih.gov/41601259/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,42743729,Enterococcus faecalis GP1764 induces an early differential gene expression in the intestine on key pathways related to cellular immune response and gut barrier function in chickens.,2026,10.1016/j.psj.2026.107604,https://pubmed.ncbi.nlm.nih.gov/42743729/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,41112516,Innate immune cell LXR-β deficiency exacerbates hepatic injury and fibrosis in murine models of primary sclerosing cholangitis.,2025,10.1016/j.livres.2025.09.001,https://pubmed.ncbi.nlm.nih.gov/41112516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,39731164,"Immune deficiency phenotypes of Il2rg, Rag2 or Il2rg/Rag2 double knockout rats; establishment of human leukemia xenograft models.",2024,10.1186/s42826-024-00231-5,https://pubmed.ncbi.nlm.nih.gov/39731164/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,42367761,CXCR3 ameliorates neutrophil-dependent disease severity in SARS-CoV-2 infection by regulating CD4&lt;sup&gt;+&lt;/sup&gt; T cell recruitment.,2026,10.3389/fimmu.2026.1823264,https://pubmed.ncbi.nlm.nih.gov/42367761/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,42601022,"Suppressing α-1,6-Fucosyltransferase With a Novel Small Molecule Inhibitor Ameliorates Inflammation in Murine T-Cell-Mediated Colitis Models.",2026,10.1016/j.jcmgh.2026.101865,https://pubmed.ncbi.nlm.nih.gov/42601022/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,42845884,Physiological upregulation of RAG1 expression compromises the survival of CD4&lt;sup&gt;+&lt;/sup&gt;CD8&lt;sup&gt;+&lt;/sup&gt; thymocytes &lt;i&gt;in vitro&lt;/i&gt;.,2026,10.3389/fimmu.2026.1849780,https://pubmed.ncbi.nlm.nih.gov/42845884/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,42386939,FAM234A acts as a switch between Th17 and Treg cell fate decisions that control inflammatory bowel disease.,2026,10.1038/s41423-026-01439-2,https://pubmed.ncbi.nlm.nih.gov/42386939/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,41902554,An Update on Inborn Errors of V(D)J Recombination.,2026,10.1152/physiol.00004.2026,https://pubmed.ncbi.nlm.nih.gov/41902554/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,42213828,"Hepatitis C virus infection dynamics, treatment, and lipid nanoparticle-mediated infection in humanized liver chimeric mouse models.",2026,10.1126/sciadv.aef1160,https://pubmed.ncbi.nlm.nih.gov/42213828/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,38592712,Mending RAG2: gene editing for treatment of RAG2 deficiency.,2024,10.1182/bloodadvances.2023012079,https://pubmed.ncbi.nlm.nih.gov/38592712/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,38096800,Genetically corrected RAG2-SCID human hematopoietic stem cells restore V(D)J-recombinase and rescue lymphoid deficiency.,2024,10.1182/bloodadvances.2023011766,https://pubmed.ncbi.nlm.nih.gov/38096800/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAG2,ENSG00000175097,Unsafe,39669426,Cytosolic bacterial pathogens activate TLR pathways in tumors that synergistically enhance STING agonist cancer therapies.,2024,10.1016/j.isci.2024.111385,https://pubmed.ncbi.nlm.nih.gov/39669426/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RALGPS2,ENSG00000116191,Unsafe,40393811,Genetic effects on chromatin accessibility uncover mechanisms of liver gene regulation and quantitative traits.,2025,10.1101/gr.279741.124,https://pubmed.ncbi.nlm.nih.gov/40393811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RALGPS2,ENSG00000116191,Unsafe,34944949,RalGPS2 Interacts with Akt and PDK1 Promoting Tunneling Nanotubes Formation in Bladder Cancer and Kidney Cells Microenvironment.,2021,10.3390/cancers13246330,https://pubmed.ncbi.nlm.nih.gov/34944949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RALGPS2,ENSG00000116191,Unsafe,32802839,Integrative Analysis of Three Novel Competing Endogenous RNA Biomarkers with a Prognostic Value in Lung Adenocarcinoma.,2020,10.1155/2020/2837906,https://pubmed.ncbi.nlm.nih.gov/32802839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RALGPS2,ENSG00000116191,Unsafe,29208460,RalGPS2 is involved in tunneling nanotubes formation in 5637 bladder cancer cells.,2018,10.1016/j.yexcr.2017.11.036,https://pubmed.ncbi.nlm.nih.gov/29208460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RALGPS2,ENSG00000116191,Unsafe,24038356,The splicing landscape is globally reprogrammed during male meiosis.,2013,10.1093/nar/gkt811,https://pubmed.ncbi.nlm.nih.gov/24038356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RALGPS2,ENSG00000116191,Unsafe,27149377,RalGPS2 Is Essential for Survival and Cell Cycle Progression of Lung Cancer Cells Independently of Its Established Substrates Ral GTPases.,2016,10.1371/journal.pone.0154840,https://pubmed.ncbi.nlm.nih.gov/27149377/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RALGPS2,ENSG00000116191,Unsafe,17462626,"Functional analysis of RalGPS2, a murine guanine nucleotide exchange factor for RalA GTPase.",2007,10.1016/j.yexcr.2007.03.016,https://pubmed.ncbi.nlm.nih.gov/17462626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RALGPS2,ENSG00000116191,Unsafe,27699500,Identification of HIF-2α-regulated genes that play a role in human microvascular endothelial sprouting during prolonged hypoxia in vitro.,2017,10.1007/s10456-016-9527-4,https://pubmed.ncbi.nlm.nih.gov/27699500/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RALGPS2,ENSG00000116191,Unsafe,20025911,The PH-PxxP domain of RalGPS2 promotes PC12 cells differentiation acting as a dominant negative for RalA GTPase activation.,2010,10.1016/j.neures.2009.11.013,https://pubmed.ncbi.nlm.nih.gov/20025911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RALGPS2,ENSG00000116191,Unsafe,25361553,Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension.,2015,10.1161/circulationaha.114.013317,https://pubmed.ncbi.nlm.nih.gov/25361553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RALGPS2,ENSG00000116191,Unsafe,22923468,Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.,2012,10.2337/db11-0550,https://pubmed.ncbi.nlm.nih.gov/22923468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,42643907,Transcriptomic Features Predict Survival in Glioblastoma Patients.,2026,10.7759/cureus.113401,https://pubmed.ncbi.nlm.nih.gov/42643907/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,42058215,"Integrated clinicopathological, genomic, and immunophenotypic landscape of renal tubulocystic oncocytoma.",2026,10.3389/fimmu.2026.1728022,https://pubmed.ncbi.nlm.nih.gov/42058215/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,41722227,Research note: Integration of GWAS and RNA-seq identifies mutations linked to within feather patterning in domestic chickens.,2026,10.1016/j.psj.2026.106645,https://pubmed.ncbi.nlm.nih.gov/41722227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,38438257,RANBP17 Overexpression Restores Nucleocytoplasmic Transport and Ameliorates Neurodevelopment in Induced DYT1 Dystonia Motor Neurons.,2024,10.1523/jneurosci.1728-23.2024,https://pubmed.ncbi.nlm.nih.gov/38438257/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,41693862,Metagenomic and metatranscriptomic profiling of bronchoalveolar lavage fluid identifies microbial and host biomarkers of drug-resistant tuberculosis.,2025,10.3389/fcimb.2025.1726935,https://pubmed.ncbi.nlm.nih.gov/41693862/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,35850701,The importin beta superfamily member RanBP17 exhibits a role in cell proliferation and is associated with improved survival of patients with HPV+ HNSCC.,2022,10.1186/s12885-022-09854-0,https://pubmed.ncbi.nlm.nih.gov/35850701/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,38697125,NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors.,2024,10.1016/j.xgen.2024.100550,https://pubmed.ncbi.nlm.nih.gov/38697125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,37606455,Excessive Gestational Weight Gain Alters DNA Methylation and Influences Foetal and Neonatal Body Composition.,2023,10.3390/epigenomes7030018,https://pubmed.ncbi.nlm.nih.gov/37606455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,34818212,Hyperbaric oxygen therapy induces transcriptome changes in elderly: a prospective trial.,2021,10.18632/aging.203709,https://pubmed.ncbi.nlm.nih.gov/34818212/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,37086484,"The Mutational, Prognostic, and Therapeutic Landscape of Neuroendocrine Neoplasms.",2023,10.1093/oncolo/oyad093,https://pubmed.ncbi.nlm.nih.gov/37086484/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,34093832,Overexpressed circRANBP17 acts as an oncogene to facilitate nasopharyngeal carcinoma via the miR-635/RUNX2 axis.,2021,10.7150/jca.55794,https://pubmed.ncbi.nlm.nih.gov/34093832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,34575904,Genetic and Epigenetic Characterization of a Discordant KMT2A/AFF1-Rearranged Infant Monozygotic Twin Pair.,2021,10.3390/ijms22189740,https://pubmed.ncbi.nlm.nih.gov/34575904/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,21184802,RANBP17 is localized to the XY body of spermatocytes and interacts with SPEM1 on the manchette of elongating spermatids.,2011,10.1016/j.mce.2010.12.021,https://pubmed.ncbi.nlm.nih.gov/21184802/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,26456686,Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.,2015,10.1016/j.stem.2015.09.001,https://pubmed.ncbi.nlm.nih.gov/26456686/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,35178089,Identification and Validation of a Hypoxia-Immune-Based Prognostic mRNA Signature for Oral Squamous Cell Carcinoma.,2022,10.1155/2022/5286251,https://pubmed.ncbi.nlm.nih.gov/35178089/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,31379707,A Risk Classification System With Five-Gene for Survival Prediction of Glioblastoma Patients.,2019,10.3389/fneur.2019.00745,https://pubmed.ncbi.nlm.nih.gov/31379707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,20503194,Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12.,2010,10.1002/jcb.22689,https://pubmed.ncbi.nlm.nih.gov/20503194/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,26580069,Analysis of Stage-Specific Gene Expression Profiles in the Uterine Endometrium during Pregnancy in Pigs.,2015,10.1371/journal.pone.0143436,https://pubmed.ncbi.nlm.nih.gov/26580069/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,24490135,The role of Importin-βs in the maintenance and lineage commitment of mouse embryonic stem cells.,2014,10.1016/j.fob.2014.01.001,https://pubmed.ncbi.nlm.nih.gov/24490135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,11071879,Identification of a novel putative Ran-binding protein and its close homologue.,2000,10.1006/bbrc.2000.3788,https://pubmed.ncbi.nlm.nih.gov/11071879/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,16926283,HOX11L2/TLX3 is transcriptionally activated through T-cell regulatory elements downstream of BCL11B as a result of the t(5;14)(q35;q32).,2006,10.1182/blood-2006-07-032953,https://pubmed.ncbi.nlm.nih.gov/16926283/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,12399963,Disruption of the RanBP17/Hox11L2 region by recombination with the TCRdelta locus in acute lymphoblastic leukemias with t(5;14)(q34;q11).,2002,10.1038/sj.leu.2402671,https://pubmed.ncbi.nlm.nih.gov/12399963/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,15334547,Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia.,2004,10.1002/gcc.20088,https://pubmed.ncbi.nlm.nih.gov/15334547/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,18628311,Mapping of 5q35 chromosomal rearrangements within a genomically unstable region.,2008,10.1136/jmg.2008.058883,https://pubmed.ncbi.nlm.nih.gov/18628311/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,12661009,Activation of HOX11L2 by juxtaposition with 3'-BCL11B in an acute lymphoblastic leukemia cell line (HPB-ALL) with t(5;14)(q35;q32.2).,2003,10.1002/gcc.10194,https://pubmed.ncbi.nlm.nih.gov/12661009/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,11587205,"A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia.",2001,10.1038/sj.leu.2402249,https://pubmed.ncbi.nlm.nih.gov/11587205/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RANBP17,ENSG00000204764,Unsafe,12970786,t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH).,2003,10.1038/sj.leu.2403061,https://pubmed.ncbi.nlm.nih.gov/12970786/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,42274819,A de novo Loss-of-function Variant in RAPGEF6 Supports its Role in Neuropsychiatric Disorders.,2026,10.1007/s12031-026-02557-2,https://pubmed.ncbi.nlm.nih.gov/42274819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,41081959,RAPGEF6 is a key biomarker with temporal characteristics in sepsis and exacerbates inflammation and oxidative stress by NF-κB-mediated necroptosis.,2025,10.1007/s10142-025-01714-x,https://pubmed.ncbi.nlm.nih.gov/41081959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,39923209,Novel ETV6::RAPGEF6 fusion gene in chronic eosinophilic leukemia: compiling evidence on the role of IL3 overexpression in tumorigenesis.,2025,10.1007/s00277-025-06217-0,https://pubmed.ncbi.nlm.nih.gov/39923209/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,37175811,Alternative Splicing Changes Promoted by NOVA2 Upregulation in Endothelial Cells and Relevance for Gastric Cancer.,2023,10.3390/ijms24098102,https://pubmed.ncbi.nlm.nih.gov/37175811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,41855919,"Genome-wide association study of fitness traits in local Alpine cattle breeds: insights into longevity, fertility, and udder health.",2026,10.1016/j.animal.2026.101789,https://pubmed.ncbi.nlm.nih.gov/41855919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,39361430,Exploring genetic and immune cell dynamics in systemic lupus erythematosus patients with Epstein-Barr virus infection via machine learning.,2025,10.1093/rheumatology/keae537,https://pubmed.ncbi.nlm.nih.gov/39361430/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,30135582,RAP2 mediates mechanoresponses of the Hippo pathway.,2018,10.1038/s41586-018-0444-0,https://pubmed.ncbi.nlm.nih.gov/30135582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,35741792,Integrated Analysis of mRNAs and Long Non-Coding RNAs Expression of Oviduct That Provides Novel Insights into the Prolificacy Mechanism of Goat (Capra hircus).,2022,10.3390/genes13061031,https://pubmed.ncbi.nlm.nih.gov/35741792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,29747665,"Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain.",2018,10.1186/s13041-018-0370-y,https://pubmed.ncbi.nlm.nih.gov/29747665/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,26057047,"Deletion of Rapgef6, a candidate schizophrenia susceptibility gene, disrupts amygdala function in mice.",2015,10.1038/tp.2015.75,https://pubmed.ncbi.nlm.nih.gov/26057047/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,34176176,Targeted RNA sequencing in the routine clinical detection of fusion genes in salivary gland tumors.,2021,10.1002/gcc.22979,https://pubmed.ncbi.nlm.nih.gov/34176176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,31647804,A RAPGEF6 variant constitutes a major risk factor for laryngeal paralysis in dogs.,2019,10.1371/journal.pgen.1008416,https://pubmed.ncbi.nlm.nih.gov/31647804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,33065998,Mutational Profile of Malignant Pleural Mesothelioma (MPM) in the Phase II RAMES Study.,2020,10.3390/cancers12102948,https://pubmed.ncbi.nlm.nih.gov/33065998/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,28970849,Gene Regulatory Network Analysis for Triple-Negative Breast Neoplasms by Using Gene Expression Data.,2017,10.4048/jbc.2017.20.3.240,https://pubmed.ncbi.nlm.nih.gov/28970849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,27390776,"Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide Exchange Factors for Rap1 Small GTPase, in Formation of Apical Surface Adherens Junctions and Neural Progenitor Development in the Mouse Cerebral Cortex.",2016,10.1523/eneuro.0142-16.2016,https://pubmed.ncbi.nlm.nih.gov/27390776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,20800573,"BAG3 directly associates with guanine nucleotide exchange factor of Rap1, PDZGEF2, and regulates cell adhesion.",2010,10.1016/j.bbrc.2010.08.092,https://pubmed.ncbi.nlm.nih.gov/20800573/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,36918797,Identification of candidate genomic regions for egg yolk moisture content based on a genome-wide association study.,2023,10.1186/s12864-023-09221-8,https://pubmed.ncbi.nlm.nih.gov/36918797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,31137587,Novel Polymorphisms in RAPGEF6 Gene Associated with Egg-Laying Rate in Chinese Jing Hong Chicken using Genome-Wide SNP Scan.,2019,10.3390/genes10050384,https://pubmed.ncbi.nlm.nih.gov/31137587/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,32339978,Genomic analysis in short- and long-term patients with malignant pleura mesothelioma treated with palliative chemotherapy.,2020,10.1016/j.ejca.2020.03.002,https://pubmed.ncbi.nlm.nih.gov/32339978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,30520388,miR-342-5p as a Potential Regulator of HER2 Breast Cancer Cell Growth.,2019,10.2174/2211536608666181206124922,https://pubmed.ncbi.nlm.nih.gov/30520388/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,33444859,Weighted gene co-expression network analysis and drug-gene interaction bioinformatics uncover key genes associated with various presentations of malaria infection in African children and major drug candidates.,2021,10.1016/j.meegid.2021.104723,https://pubmed.ncbi.nlm.nih.gov/33444859/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RAPGEF6,ENSG00000158987,Unsafe,11524421,"Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras.",2001,10.1074/jbc.m105760200,https://pubmed.ncbi.nlm.nih.gov/11524421/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,41146286,Rational design of promoter editing confers multipathogen resistance in rice.,2025,10.1186/s13059-025-03841-x,https://pubmed.ncbi.nlm.nih.gov/41146286/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,41155196,The Tumor Suppressor p53 Downregulates p107 (&lt;i&gt;RBL1&lt;/i&gt;) Through p21-RB/E2F Signaling and Tandem E2F Sites.,2025,10.3390/ijms26209903,https://pubmed.ncbi.nlm.nih.gov/41155196/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,39406384,Tumor suppressors RBL1 and PTEN are epigenetically silenced in IPF mesenchymal progenitor cells by a CD44/Brg1/PRMT5 regulatory complex.,2024,10.1152/ajplung.00182.2024,https://pubmed.ncbi.nlm.nih.gov/39406384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,41258103,Myogenic enhancer snatching promotes adipogenic differentiation during epigenetic reprogramming mediated by lineage-specific transcription factors.,2025,10.1007/s00018-025-05901-8,https://pubmed.ncbi.nlm.nih.gov/41258103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,41724981,Cell-of-origin and genetic drivers define advanced bladder cancer subtypes and potential therapeutic response in mouse models.,2026,10.1186/s13046-026-03677-8,https://pubmed.ncbi.nlm.nih.gov/41724981/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,38167011,"Bioinformatic identification and experiment validation reveal 6 hub genes, promising diagnostic and therapeutic targets for Alzheimer's disease.",2024,10.1186/s12920-023-01775-6,https://pubmed.ncbi.nlm.nih.gov/38167011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,41749843,Mechanisms of the Antiproliferative Effects of SIRT6 Inhibition in Melanoma: A Multi-Omics Analysis.,2026,10.3390/cancers18040590,https://pubmed.ncbi.nlm.nih.gov/41749843/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,40750862,MicroRNA-21-5p from induced pluripotent stem cells promotes neuroprotection of retinal ganglion cells in optic nerve crush model.,2025,10.1186/s12886-025-04244-z,https://pubmed.ncbi.nlm.nih.gov/40750862/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,42105620,Transcriptome and metabolome analysis reveals that cuproptosis in bovine cumulus cells triggers the intercellular transmission of senescence and mitochondrial dysfunction to impair oocyte quality.,2026,10.1016/j.theriogenology.2026.117974,https://pubmed.ncbi.nlm.nih.gov/42105620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,40704068,Modelling the liver's regenerative capacity across different clinical conditions.,2025,10.1016/j.jhepr.2025.101465,https://pubmed.ncbi.nlm.nih.gov/40704068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,37316672,Genome editing of a rice CDP-DAG synthase confers multipathogen resistance.,2023,10.1038/s41586-023-06205-2,https://pubmed.ncbi.nlm.nih.gov/37316672/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,40307557,Cell cycle duration determines oncogenic transformation capacity.,2025,10.1038/s41586-025-08935-x,https://pubmed.ncbi.nlm.nih.gov/40307557/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,39946028,Identification of differentially expressed MiRNA clusters in cervical cancer.,2025,10.1007/s12672-025-01946-0,https://pubmed.ncbi.nlm.nih.gov/39946028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,38959035,Nonviral CRISPR/Cas9 mutagenesis for streamlined generation of mouse lung cancer models.,2024,10.1073/pnas.2322917121,https://pubmed.ncbi.nlm.nih.gov/38959035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,40636307,Vemurafenib Induces Senescent Phenotype with Increased Adhesion in BRAF Mutant A375 but not in Wild Type BRAF SK-MEL-2 Melanoma Cells.,2025,10.34172/apb.42808,https://pubmed.ncbi.nlm.nih.gov/40636307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,39229560,A new TGF-β risk score predicts clinical and immune landscape in colorectal cancer patients.,2024,10.1002/ags3.12802,https://pubmed.ncbi.nlm.nih.gov/39229560/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,36413521,"Simultaneous depletion of RB, RBL1 and RBL2 affects endoderm differentiation of human embryonic stem cells.",2022,10.1371/journal.pone.0269122,https://pubmed.ncbi.nlm.nih.gov/36413521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,40352177,Ethanol extract from &lt;i&gt;Ziziphus nummularia&lt;/i&gt; stem inhibits MCF-7 breast cancer cell proliferation through TP53 regulating kinase (TP53RK)-mediated p53 activation: In silico and genes expression investigations.,2025,10.52225/narra.v5i1.1382,https://pubmed.ncbi.nlm.nih.gov/40352177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,34638509,RBL1/p107 Expression Levels Are Modulated by Multiple Signaling Pathways.,2021,10.3390/cancers13195025,https://pubmed.ncbi.nlm.nih.gov/34638509/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,37234568,Bioinformatics-Based Identification of CircRNA-MicroRNA-mRNA Network for Calcific Aortic Valve Disease.,2023,10.1155/2023/8194338,https://pubmed.ncbi.nlm.nih.gov/37234568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,40974543,&lt;i&gt;RBL1&lt;/i&gt; Shapes Phyllosphere Microbial Structure to Enhance Disease Resistance in Rice.,2025,10.1094/mpmi-08-25-0097-r,https://pubmed.ncbi.nlm.nih.gov/40974543/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,37676404,Genome editing enables defense-yield balance in rice.,2023,10.1007/s44154-023-00102-4,https://pubmed.ncbi.nlm.nih.gov/37676404/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,37562091,Xanthatin suppresses pancreatic cancer cell growth via the ROS/RBL1 signaling pathway: In vitro and in vivo insights.,2023,10.1016/j.phymed.2023.155004,https://pubmed.ncbi.nlm.nih.gov/37562091/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,37759078,CSE1L is a negative regulator of the RB-DREAM pathway in p53 wild-type NSCLC and can be targeted using an HDAC1/2 inhibitor.,2023,10.1038/s41598-023-43218-3,https://pubmed.ncbi.nlm.nih.gov/37759078/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,38672200,Tumors Established in a Defective Immune Environment Reprogram the Oncogenic Signaling Pathways to Escalate Tumor Antigenicity.,2024,10.3390/biomedicines12040846,https://pubmed.ncbi.nlm.nih.gov/38672200/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,33567262,Germline genetic contribution to the immune landscape of cancer.,2021,10.1016/j.immuni.2021.01.011,https://pubmed.ncbi.nlm.nih.gov/33567262/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,35058503,RBL2/DREAM-mediated repression of the Aurora kinase A/B pathway determines therapy responsiveness and outcome in p53 WT NSCLC.,2022,10.1038/s41598-022-05013-4,https://pubmed.ncbi.nlm.nih.gov/35058503/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,36950649,The somatic mutational landscape and role of the ARID1A gene in hepatocellular carcinoma.,2023,10.1016/j.heliyon.2023.e14307,https://pubmed.ncbi.nlm.nih.gov/36950649/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,35267571,Understanding Retinoblastoma Post-Translational Regulation for the Design of Targeted Cancer Therapies.,2022,10.3390/cancers14051265,https://pubmed.ncbi.nlm.nih.gov/35267571/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,33333220,Characterization and functional analysis of SMAD2 regulation in hair follicle cycle in Angora rabbits.,2021,10.1016/j.gene.2020.145339,https://pubmed.ncbi.nlm.nih.gov/33333220/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,27739525,CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis.,2016,10.1038/srep35264,https://pubmed.ncbi.nlm.nih.gov/27739525/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBL1,ENSG00000080839,Unsafe,35565295,RB1-Negative Retinal Organoids Display Proliferation of Cone Photoreceptors and Loss of Retinal Differentiation.,2022,10.3390/cancers14092166,https://pubmed.ncbi.nlm.nih.gov/35565295/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM12B,ENSG00000183808,Unsafe,38458543,Identification of splicing factors signature predicting prognosis risk and the mechanistic roles of novel oncogenes in HNSCC.,2024,10.1016/j.bbadis.2024.167115,https://pubmed.ncbi.nlm.nih.gov/38458543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM12B,ENSG00000183808,Unsafe,30914425,Identification of a Rat Mammary Tumor Risk Locus That Is Syntenic with the Commonly Amplified 8q12.1 and 8q22.1 Regions in Human Breast Cancer Patients.,2019,10.1534/g3.118.200873,https://pubmed.ncbi.nlm.nih.gov/30914425/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM12B,ENSG00000183808,Unsafe,32468035,Identification of prognostic biomarkers and drug target prediction for colon cancer according to a competitive endogenous RNA network.,2020,10.3892/mmr.2020.11171,https://pubmed.ncbi.nlm.nih.gov/32468035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM12B,ENSG00000183808,Unsafe,31506425,High throughput circRNA sequencing analysis reveals novel insights into the mechanism of nitidine chloride against hepatocellular carcinoma.,2019,10.1038/s41419-019-1890-9,https://pubmed.ncbi.nlm.nih.gov/31506425/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM12B,ENSG00000183808,Unsafe,22984568,Peripheral blood gene expression as a novel genomic biomarker in complicated sarcoidosis.,2012,10.1371/journal.pone.0044818,https://pubmed.ncbi.nlm.nih.gov/22984568/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM12B,ENSG00000183808,Unsafe,20926767,Late-gestational systemic hypoxia leads to a similar early gene response in mouse placenta and developing brain.,2010,10.1152/ajpregu.00697.2009,https://pubmed.ncbi.nlm.nih.gov/20926767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,42656824,Fluorogenic Tissue-Based Assessment of Acid Ceramidase Activity.,2026,10.21769/bioprotoc.5778,https://pubmed.ncbi.nlm.nih.gov/42656824/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,42785546,Paraspeckles translate microbial insult-induced inflammation into neurovascular remodeling by enhancing CYR61-FGF2 signaling via RBM14 sequestration.,2026,10.1016/j.lfs.2026.124708,https://pubmed.ncbi.nlm.nih.gov/42785546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,42603258,Antimicrobial Peptide BSN-37 Enhances Macrophage Immune Activation Through the circBptf-Rbm14-Mediated Regulatory Axis.,2026,10.1007/s12602-026-11174-9,https://pubmed.ncbi.nlm.nih.gov/42603258/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,42062247,RBM14 drives prostate cancer metastasis via stabilizing HK2 mRNA to activate glycolysis and H3K18 lactylation.,2026,10.1038/s41420-026-03131-w,https://pubmed.ncbi.nlm.nih.gov/42062247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,41299552,Protective effects of mouse bone marrow mesenchymal stem cell-derived extracellular vesicles on radiation-induced epididymal cells damage via USP44/RBM14 axis.,2025,10.1186/s13287-025-04782-9,https://pubmed.ncbi.nlm.nih.gov/41299552/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,42140427,Nuclear Proteome Map of Mouse Heart Chambers.,2026,10.1016/j.mcpro.2026.101585,https://pubmed.ncbi.nlm.nih.gov/42140427/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,42374457,Regulatory mechanisms driven by functional 3'-UTR variants in alcohol use disorder and related traits.,2026,10.1186/s13059-026-04176-x,https://pubmed.ncbi.nlm.nih.gov/42374457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,38881928,"Molecular mechanism of RBM14-mediated promotion of proliferation, migration, and invasion in osteosarcoma.",2024,10.21037/tcr-23-2070,https://pubmed.ncbi.nlm.nih.gov/38881928/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,39870664,A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer.,2025,10.1038/s41467-025-56301-2,https://pubmed.ncbi.nlm.nih.gov/39870664/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,40654360,RBM14 enhances transcriptional activity of p23 regulating CXCL1 expression to induce lung cancer metastasis.,2025,10.1016/j.apsb.2025.03.048,https://pubmed.ncbi.nlm.nih.gov/40654360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,37559455,RBM14 promotes DNA end resection during homologous recombination repair.,2023,10.3724/abbs.2023104,https://pubmed.ncbi.nlm.nih.gov/37559455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,37060064,RBM14 as a novel epigenetic-activated tumor oncogene is implicated in the reprogramming of glycolysis in lung cancer.,2023,10.1186/s12957-023-02928-8,https://pubmed.ncbi.nlm.nih.gov/37060064/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,39303930,The effects of all-trans retinoic acid on prednisolone-induced osteoporosis in zebrafish larvae.,2024,10.1016/j.bone.2024.117261,https://pubmed.ncbi.nlm.nih.gov/39303930/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,38678556,O-GlcNAcylation of RBM14 contributes to elevated cellular O-GlcNAc through regulation of OGA protein stability.,2024,10.1016/j.celrep.2024.114163,https://pubmed.ncbi.nlm.nih.gov/38678556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,38411947,RBM14 inhibits the replication of porcine epidemic diarrhea virus by recruiting p62 to degrade nucleocapsid protein through the activation of autophagy and interferon pathway.,2024,10.1128/jvi.00182-24,https://pubmed.ncbi.nlm.nih.gov/38411947/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,37930826,The RNA-binding motif protein 14 regulates telomere integrity at the interface of TERRA and telomeric R-loops.,2023,10.1093/nar/gkad967,https://pubmed.ncbi.nlm.nih.gov/37930826/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,37806532,RNA-binding protein 14 promotes phase separation to sustain prostate specific antigen expression under androgen deprivation in human prostate cancer.,2023,10.1016/j.jsbmb.2023.106407,https://pubmed.ncbi.nlm.nih.gov/37806532/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,40248935,Identification of the Role of Necroptosis-Related Genes in the Oxidative Damage of Lens Epithelial Cells and Validation in Ultraviolet B-induced Cataract in Rats.,2026,10.2174/0113862073365864250312043532,https://pubmed.ncbi.nlm.nih.gov/40248935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,36339704,Gut microbiota-dependent adaptor molecule recruits DNA methyltransferase to the TLR4 gene in colonic epithelial cells to suppress inflammatory reactions.,2022,10.3389/fmolb.2022.1005136,https://pubmed.ncbi.nlm.nih.gov/36339704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,35669242,Solute Carrier Family 35 Member F2 Regulates Cisplatin Resistance and Promotes Malignant Progression of Pancreatic Cancer by Regulating RNA Binding Motif Protein 14.,2022,10.1155/2022/5091154,https://pubmed.ncbi.nlm.nih.gov/35669242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,37689270,Toxic effects of exogenous retinoic acid on the neurodevelopment of zebrafish (Danio rerio) embryos.,2023,10.1016/j.ntt.2023.107291,https://pubmed.ncbi.nlm.nih.gov/37689270/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,39159158,G0 arrest gene patterns to predict the prognosis and drug sensitivity of patients with lung adenocarcinoma.,2024,10.1371/journal.pone.0309076,https://pubmed.ncbi.nlm.nih.gov/39159158/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,37002788,Up-regulation of PRKDC was associated with poor renal dysfunction after renal transplantation: A multi-centre analysis.,2023,10.1111/jcmm.17737,https://pubmed.ncbi.nlm.nih.gov/37002788/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,34980126,A genomic mutation spectrum of collecting duct carcinoma in the Chinese population.,2022,10.1186/s12920-021-01143-2,https://pubmed.ncbi.nlm.nih.gov/34980126/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,34150040,Prognostic gene biomarker identification in liver cancer by data mining.,2021,,https://pubmed.ncbi.nlm.nih.gov/34150040/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,29075020,"The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ.",2017,10.1038/s41598-017-14570-y,https://pubmed.ncbi.nlm.nih.gov/29075020/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,25589658,Mining the human complexome database identifies RBM14 as an XPO1-associated protein involved in HIV-1 Rev function.,2015,10.1128/jvi.03232-14,https://pubmed.ncbi.nlm.nih.gov/25589658/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,26283796,Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles.,2015,10.1083/jcb.201504117,https://pubmed.ncbi.nlm.nih.gov/26283796/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,33020388,Dietary Erythrodiol Modifies Hepatic Transcriptome in Mice in a Sex and Dose-Dependent Way.,2020,10.3390/ijms21197331,https://pubmed.ncbi.nlm.nih.gov/33020388/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,22952932,Identification of thalidomide-specific transcriptomics and proteomics signatures during differentiation of human embryonic stem cells.,2012,10.1371/journal.pone.0044228,https://pubmed.ncbi.nlm.nih.gov/22952932/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM14,ENSG00000239306,Unsafe,22761693,Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination.,2012,10.1371/journal.pone.0038658,https://pubmed.ncbi.nlm.nih.gov/22761693/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM34,ENSG00000188739,Unsafe,42087228,Profiling cell dynamic changes of goat peripheral blood mononuclear cells after Pasteurella multocida infection with single-cell transcriptomics and histopathology.,2026,10.1186/s13567-025-01661-2,https://pubmed.ncbi.nlm.nih.gov/42087228/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM34,ENSG00000188739,Unsafe,38058813,Oncogenic and immunological values of RBM34 in osteosarcoma and its pan-cancer analysis.,2023,,https://pubmed.ncbi.nlm.nih.gov/38058813/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM34,ENSG00000188739,Unsafe,41581355,Integrative genome-wide association study and transcriptomic analysis to identify candidate genes and pathways for heterophil and lymphocyte traits in white-feathered broilers.,2026,10.1016/j.psj.2026.106407,https://pubmed.ncbi.nlm.nih.gov/41581355/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM34,ENSG00000188739,Unsafe,36643033,Overexpression of RBM34 Promotes Tumor Progression and Correlates with Poor Prognosis of Hepatocellular Carcinoma.,2023,10.14218/jcth.2022.00166,https://pubmed.ncbi.nlm.nih.gov/36643033/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM34,ENSG00000188739,Unsafe,39710061,The RNA-binding protein CMSS1 promotes the progression of non-small cell lung cancer by regulating the telomerase protein subunit hTERT.,2025,10.1016/j.lfs.2024.123321,https://pubmed.ncbi.nlm.nih.gov/39710061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM34,ENSG00000188739,Unsafe,34926575,Development and Validation of Ten-RNA Binding Protein Signature Predicts Overall Survival in Osteosarcoma.,2021,10.3389/fmolb.2021.751842,https://pubmed.ncbi.nlm.nih.gov/34926575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM34,ENSG00000188739,Unsafe,36506302,Construction of cuproptosis-related gene signature to predict the prognosis and immunotherapy efficacy of patients with bladder cancer through bioinformatics analysis and experimental validation.,2022,10.3389/fgene.2022.1074981,https://pubmed.ncbi.nlm.nih.gov/36506302/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM34,ENSG00000188739,Unsafe,34853590,Construction and Validation of a Potent Epigenetic Modification-Related Prognostic Signature for Osteosarcoma Patients.,2021,10.1155/2021/2719172,https://pubmed.ncbi.nlm.nih.gov/34853590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM34,ENSG00000188739,Unsafe,32970748,The association between poverty and gene expression within peripheral blood mononuclear cells in a diverse Baltimore City cohort.,2020,10.1371/journal.pone.0239654,https://pubmed.ncbi.nlm.nih.gov/32970748/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM34,ENSG00000188739,Unsafe,26216192,Functional Networks of Highest-Connected Splice Isoforms: From The Chromosome 17 Human Proteome Project.,2015,10.1021/acs.jproteome.5b00494,https://pubmed.ncbi.nlm.nih.gov/26216192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM34,ENSG00000188739,Unsafe,35073835,"Non-additive QTL mapping of lactation traits in 124,000 cattle reveals novel recessive loci.",2022,10.1186/s12711-021-00694-3,https://pubmed.ncbi.nlm.nih.gov/35073835/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM34,ENSG00000188739,Unsafe,15134903,Microarray analysis of differentially expressed genes in cells resistant to HIV-1.,2004,10.1016/j.imlet.2004.02.009,https://pubmed.ncbi.nlm.nih.gov/15134903/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM34,ENSG00000188739,Unsafe,39633110,Integrated explainable machine learning and multi-omics analysis for survival prediction in cancer with immunotherapy response.,2025,10.1007/s10495-024-02050-4,https://pubmed.ncbi.nlm.nih.gov/39633110/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM34,ENSG00000188739,Unsafe,16469478,Proteomic analysis of the response of EpiDerm cultures to sodium lauryl sulphate.,2006,10.1016/j.tiv.2005.12.007,https://pubmed.ncbi.nlm.nih.gov/16469478/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,42596848,piR‑164552 promotes malignant progression in head and neck squamous cell carcinoma via the RBM4/EIF4E2 signaling axis: Insights from multi‑omics and functional analyses.,2026,10.3892/ijo.2026.5924,https://pubmed.ncbi.nlm.nih.gov/42596848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,42900796,RBM4 Stabilizes S100A10 mRNA to Remodel the Tumor Immune Microenvironment and Promote Immune Evasion in Hepatocellular Carcinoma.,2026,10.1002/mc.70197,https://pubmed.ncbi.nlm.nih.gov/42900796/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,42711653,RBM4 Promotes Nasopharyngeal Carcinoma Growth and Metastasis by Stabilizing HOXB13 mRNA.,2026,10.1007/s12013-026-02139-4,https://pubmed.ncbi.nlm.nih.gov/42711653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,42045977,The role of alternative splicing in gastric cancer.,2026,10.1186/s13062-026-00813-4,https://pubmed.ncbi.nlm.nih.gov/42045977/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,41757512,m&lt;sup&gt;5&lt;/sup&gt;C-Modified tRF3b-Cys&lt;sup&gt;GCA&lt;/sup&gt;-23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4.,2026,10.1002/advs.202522294,https://pubmed.ncbi.nlm.nih.gov/41757512/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,41003853,"Hsa_circ_0075451 promotes NSCLC proliferation, metastasis, and glycolysis through interaction with the RNA-binding protein RBM4.",2025,10.1007/s12672-025-03330-4,https://pubmed.ncbi.nlm.nih.gov/41003853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,39738787,RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar foliation.,2024,10.1038/s42003-024-07328-6,https://pubmed.ncbi.nlm.nih.gov/39738787/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,42249082,The translation landscape of ovarian clear cell carcinoma indicates that RBM4 plays a pro-oncogenic role in tumor progression.,2026,10.1038/s41388-026-03840-7,https://pubmed.ncbi.nlm.nih.gov/42249082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,39118568,Endogenous RBM4 prevents Ang II-induced cardiomyocyte hypertrophy via downregulating the expression of PTBP1.,2024,10.3724/abbs.2024103,https://pubmed.ncbi.nlm.nih.gov/39118568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,37670183,Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency.,2023,10.1038/s42003-023-05294-z,https://pubmed.ncbi.nlm.nih.gov/37670183/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,39214303,Overexpression of RBM4 promotes acute myeloid leukemia cell differentiation by regulating alternative splicing of TFEB.,2024,10.1016/j.jbc.2024.107729,https://pubmed.ncbi.nlm.nih.gov/39214303/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,39865075,The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis.,2025,10.1038/s41392-025-02128-8,https://pubmed.ncbi.nlm.nih.gov/39865075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,41543171,RNA G-quadruplexes promote codon repeat-associated ribosomal frameshifting in human genes.,2026,10.1093/nar/gkaf1481,https://pubmed.ncbi.nlm.nih.gov/41543171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,37415951,Aurora kinase A regulates cancer-associated RNA aberrant splicing in breast cancer.,2023,10.1016/j.heliyon.2023.e17386,https://pubmed.ncbi.nlm.nih.gov/37415951/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,38455069,Identification and validation of protein biomarkers for predicting gastrointestinal stromal tumor recurrence.,2024,10.1016/j.csbj.2024.02.017,https://pubmed.ncbi.nlm.nih.gov/38455069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,37080995,RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis.,2023,10.1038/s41392-023-01367-x,https://pubmed.ncbi.nlm.nih.gov/37080995/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,38420804,A Comprehensive Prognostic and Immune Infiltration Analysis of RBM4 in Pan-Cancer.,2024,10.31083/j.fbl2902089,https://pubmed.ncbi.nlm.nih.gov/38420804/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,41552916,Machine learning integrated extracellular vesicle proteome analysis for early markers of bronchopulmonary dysplasia.,2026,10.1152/function.090.2025,https://pubmed.ncbi.nlm.nih.gov/41552916/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,35361747,Nuclear Aurora kinase A switches m6A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4.,2022,10.1038/s41392-022-00905-3,https://pubmed.ncbi.nlm.nih.gov/35361747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,41451538,Deciphering RNA modification and post-transcriptional regulation with NetRNApan.,2025,10.1093/bib/bbaf690,https://pubmed.ncbi.nlm.nih.gov/41451538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,40373256,CircRNA GRAMD4 induces NBR1 expression to promote autophagy and immune escape in renal cell carcinoma.,2025,10.1080/15548627.2025.2503560,https://pubmed.ncbi.nlm.nih.gov/40373256/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,38548747,FUT8-mediated aberrant N-glycosylation of SEMA7A promotes head and neck squamous cell carcinoma progression.,2024,10.1038/s41368-024-00289-w,https://pubmed.ncbi.nlm.nih.gov/38548747/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,38164794,RNA binding motif 4 inhibits the replication of ebolavirus by directly targeting 3'-leader region of genomic RNA.,2024,10.1080/22221751.2023.2300762,https://pubmed.ncbi.nlm.nih.gov/38164794/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,36639375,RBM4 regulates cellular senescence via miR1244/SERPINE1 axis.,2023,10.1038/s41419-023-05563-z,https://pubmed.ncbi.nlm.nih.gov/36639375/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,39538416,Molecular characterization of human HSPCs with different cell fates in vivo using single-cell transcriptome analysis and lentiviral barcoding technology.,2024,10.1002/ctm2.70085,https://pubmed.ncbi.nlm.nih.gov/39538416/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,36712961,Hypergravity enhances RBM4 expression in human bone marrow-derived mesenchymal stem cells and accelerates their differentiation into neurons.,2023,10.1016/j.reth.2022.12.010,https://pubmed.ncbi.nlm.nih.gov/36712961/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,31234575,Berberine Promotes Beige Adipogenic Signatures of 3T3-L1 Cells by Regulating Post-transcriptional Events.,2019,10.3390/cells8060632,https://pubmed.ncbi.nlm.nih.gov/31234575/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,27324405,Prognostic value of decreased expression of RBM4 in human gastric cancer.,2016,10.1038/srep28222,https://pubmed.ncbi.nlm.nih.gov/27324405/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,35832652,Landscape of Alternative Splicing Events Related to Prognosis and Immune Infiltration in Glioma: A Data Analysis and Basic Verification.,2022,10.1155/2022/2671891,https://pubmed.ncbi.nlm.nih.gov/35832652/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,34530456,Modulation of alternative splicing during early infection of human primary B lymphocytes with Epstein-Barr virus (EBV): a novel function for the viral EBNA-LP protein.,2021,10.1093/nar/gkab787,https://pubmed.ncbi.nlm.nih.gov/34530456/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,23825193,Mitogen-activated protein kinase phosphatase 1 disrupts proinflammatory protein synthesis in endotoxin-adapted monocytes.,2013,10.1128/cvi.00264-13,https://pubmed.ncbi.nlm.nih.gov/23825193/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,33020388,Dietary Erythrodiol Modifies Hepatic Transcriptome in Mice in a Sex and Dose-Dependent Way.,2020,10.3390/ijms21197331,https://pubmed.ncbi.nlm.nih.gov/33020388/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,26565589,"A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells.",2015,10.7554/elife.08474,https://pubmed.ncbi.nlm.nih.gov/26565589/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,18708123,The LARK/RBM4a protein is highly expressed in cerebellum as compared to cerebrum.,2008,10.1016/j.neulet.2008.08.017,https://pubmed.ncbi.nlm.nih.gov/18708123/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,16777844,RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion.,2006,10.1074/jbc.m603971200,https://pubmed.ncbi.nlm.nih.gov/16777844/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,16260624,Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB.,2005,10.1128/mcb.25.22.10111-10121.2005,https://pubmed.ncbi.nlm.nih.gov/16260624/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM4,ENSG00000173933,Unsafe,12628928,A novel splicing regulator shares a nuclear import pathway with SR proteins.,2003,10.1093/emboj/cdg126,https://pubmed.ncbi.nlm.nih.gov/12628928/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM48,ENSG00000127993,Unsafe,36040194,Genetic analysis of human RNA binding motif protein 48 (RBM48) reveals an essential role in U12-type intron splicing.,2022,10.1093/genetics/iyac129,https://pubmed.ncbi.nlm.nih.gov/36040194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM48,ENSG00000127993,Unsafe,36185995,Identification of Diagnostic Exosomal LncRNA-miRNA-mRNA Biomarkers in Colorectal Cancer Based on the ceRNA Network.,2022,10.3389/pore.2022.1610493,https://pubmed.ncbi.nlm.nih.gov/36185995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM48,ENSG00000127993,Unsafe,31400491,Androgenic regulation of sexually dimorphic expression of RNA binding motif protein 48 in the developing mouse cortex and hippocampus.,2019,10.1016/j.ijdevneu.2019.07.011,https://pubmed.ncbi.nlm.nih.gov/31400491/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM48,ENSG00000127993,Unsafe,26489029,Whole exome sequencing identifies causative mutations in the majority of consanguineous or familial cases with childhood-onset increased renal echogenicity.,2016,10.1038/ki.2015.317,https://pubmed.ncbi.nlm.nih.gov/26489029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,41381783,RBM7 suppresses mitochondrial dysfunction and ferroptosis by destabilizing FBXL16 mRNA to enhance Temozolomide resistance in glioblastoma.,2025,10.1007/s00438-025-02313-y,https://pubmed.ncbi.nlm.nih.gov/41381783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,38995840,RBM7 deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway.,2024,10.7554/elife.95318,https://pubmed.ncbi.nlm.nih.gov/38995840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,41453249,CNOT1 contributes to small nuclear non-coding RNA maturation.,2026,10.1016/j.bbrc.2025.153185,https://pubmed.ncbi.nlm.nih.gov/41453249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,39356758,Substrate recognition principles for the PP2A-B55 protein phosphatase.,2024,10.1126/sciadv.adp5491,https://pubmed.ncbi.nlm.nih.gov/39356758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,36427363,C-terminal determinants for RNA binding motif 7 protein stability and RNA recognition.,2023,10.1016/j.bpc.2022.106928,https://pubmed.ncbi.nlm.nih.gov/36427363/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,36755023,Temporal-iCLIP captures co-transcriptional RNA-protein interactions.,2023,10.1038/s41467-023-36345-y,https://pubmed.ncbi.nlm.nih.gov/36755023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,33145401,Oncogenic action of the exosome cofactor RBM7 by stabilization of CDK1 mRNA in breast cancer.,2020,10.1038/s41523-020-00200-w,https://pubmed.ncbi.nlm.nih.gov/33145401/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,34165514,Novel insights into the pathogenesis of lung fibrosis: the RBM7-NEAT1-CXCL12-SatM axis at fibrosis onset.,2021,10.1093/intimm/dxab034,https://pubmed.ncbi.nlm.nih.gov/34165514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,35688134,Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex.,2022,10.1016/j.cell.2022.04.016,https://pubmed.ncbi.nlm.nih.gov/35688134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,32146325,Srsf7 Establishes the Juvenile Transcriptome through Age-Dependent Alternative Splicing in Mice.,2020,10.1016/j.isci.2020.100929,https://pubmed.ncbi.nlm.nih.gov/32146325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,32187520,Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis.,2020,10.1016/j.immuni.2020.02.007,https://pubmed.ncbi.nlm.nih.gov/32187520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,32187513,Rbm7 in Structural Cells: A NEAT Way to Control Fibrosis.,2020,10.1016/j.immuni.2020.02.008,https://pubmed.ncbi.nlm.nih.gov/32187513/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,32708315,Revisiting Cell Death Responses in Fibrotic Lung Disease: Crosstalk between Structured and Non-Structured Cells.,2020,10.3390/diagnostics10070504,https://pubmed.ncbi.nlm.nih.gov/32708315/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,30824372,P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress.,2019,10.1016/j.molcel.2019.01.033,https://pubmed.ncbi.nlm.nih.gov/30824372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,27193168,Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.,2016,10.1093/hmg/ddw149,https://pubmed.ncbi.nlm.nih.gov/27193168/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,32527837,RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels.,2020,10.26508/lsa.202000678,https://pubmed.ncbi.nlm.nih.gov/32527837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,31002802,Activation of P-TEFb by RBM7: To Live or Let Die.,2019,10.1016/j.molcel.2019.03.039,https://pubmed.ncbi.nlm.nih.gov/31002802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,34343137,Somatic reversion impacts myelodysplastic syndromes and acute myeloid leukemia evolution in the short telomere disorders.,2021,10.1172/jci147598,https://pubmed.ncbi.nlm.nih.gov/34343137/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,35688157,Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome.,2022,10.1016/j.molcel.2022.04.011,https://pubmed.ncbi.nlm.nih.gov/35688157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,27905398,Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors.,2016,10.1038/ncomms13573,https://pubmed.ncbi.nlm.nih.gov/27905398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBM7,ENSG00000076053,Unsafe,29970143,Screening for biomarkers reflecting the progression of Babesia microti infection.,2018,10.1186/s13071-018-2951-0,https://pubmed.ncbi.nlm.nih.gov/29970143/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,39747056,Fam102a translocates Runx2 and Rbpjl to facilitate Osterix expression and bone formation.,2025,10.1038/s41467-024-55451-z,https://pubmed.ncbi.nlm.nih.gov/39747056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,40280976,Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing.,2025,10.1038/s41467-025-59216-0,https://pubmed.ncbi.nlm.nih.gov/40280976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,41301990,GWAS Reveals Key Candidate Genes Associated with Milk-Production in Saanen Goats.,2025,10.3390/ani15223282,https://pubmed.ncbi.nlm.nih.gov/41301990/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,35725649,Blockade of the Arid5a/IL-6/STAT3 axis underlies the anti-inflammatory effect of Rbpjl in acute pancreatitis.,2022,10.1186/s13578-022-00819-1,https://pubmed.ncbi.nlm.nih.gov/35725649/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,34638511,Transcription Factor RBPJL Is Able to Repress Notch Target Gene Expression but Is Non-Responsive to Notch Activation.,2021,10.3390/cancers13195027,https://pubmed.ncbi.nlm.nih.gov/34638511/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,37425649,Transcriptional Profile of Human Pancreatic Acinar Ductal Metaplasia.,2023,10.1016/j.gastha.2023.02.003,https://pubmed.ncbi.nlm.nih.gov/37425649/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,34666113,Cadmium-mediated pancreatic islet transcriptome changes in mice and cultured mouse islets.,2021,10.1016/j.taap.2021.115756,https://pubmed.ncbi.nlm.nih.gov/34666113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,32994998,p.P476S mutation of RBPJL inhibits the efficacy of anti-PD-1 therapy in oesophageal squamous cell carcinoma by blunting T-cell responses.,2020,10.1002/cti2.1172,https://pubmed.ncbi.nlm.nih.gov/32994998/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,35431492,Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis.,2022,10.3748/wjg.v28.i10.1024,https://pubmed.ncbi.nlm.nih.gov/35431492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,30470852,"Transcription factor Ptf1a in development, diseases and reprogramming.",2019,10.1007/s00018-018-2972-z,https://pubmed.ncbi.nlm.nih.gov/30470852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,31350943,Proximity labeling to detect RNA-protein interactions in live cells.,2019,10.1002/2211-5463.12706,https://pubmed.ncbi.nlm.nih.gov/31350943/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,29302047,"Functional and association analysis of an Amerindian-derived population-specific p.(Thr280Met) variant in RBPJL, a component of the PTF1 complex.",2018,10.1038/s41431-017-0062-6,https://pubmed.ncbi.nlm.nih.gov/29302047/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,23536819,The C. elegans Homolog of RBBP6 (RBPL-1) regulates fertility through controlling cell proliferation in the germline and nutrient synthesis in the intestine.,2013,10.1371/journal.pone.0058736,https://pubmed.ncbi.nlm.nih.gov/23536819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,25063451,The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.,2014,10.1242/dev.109405,https://pubmed.ncbi.nlm.nih.gov/25063451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,25546435,The human pancreas proteome defined by transcriptomics and antibody-based profiling.,2014,10.1371/journal.pone.0115421,https://pubmed.ncbi.nlm.nih.gov/25546435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,20398665,Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.,2010,10.1053/j.gastro.2010.04.003,https://pubmed.ncbi.nlm.nih.gov/20398665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,17938243,Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex.,2007,10.1101/gad.1575207,https://pubmed.ncbi.nlm.nih.gov/17938243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,23349836,Directed pancreatic acinar differentiation of mouse embryonic stem cells via embryonic signalling molecules and exocrine transcription factors.,2013,10.1371/journal.pone.0054243,https://pubmed.ncbi.nlm.nih.gov/23349836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,26909576,Genomic analyses identify molecular subtypes of pancreatic cancer.,2016,10.1038/nature16965,https://pubmed.ncbi.nlm.nih.gov/26909576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RBPJL,ENSG00000124232,Unsafe,23339455,ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours.,2013,10.1042/bj20120873,https://pubmed.ncbi.nlm.nih.gov/23339455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,41511193,Retinol dehydrogenase 10-mediated retinoic acid signaling regulates the neural crest cell microenvironment during enteric nervous system formation.,2026,10.1093/hmg/ddaf197,https://pubmed.ncbi.nlm.nih.gov/41511193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,42062396,Differential regulation of retinoic acid metabolism in Fanconi anemia.,2026,10.1038/s41598-026-50045-9,https://pubmed.ncbi.nlm.nih.gov/42062396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,42104904,Synergistic Role of Retinoid and Gata3 Signaling in Olfactory Epithelium Development.,2026,10.1002/cga.70060,https://pubmed.ncbi.nlm.nih.gov/42104904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,41752009,"FOXC1 Regulates Cytokine Signaling, Inflammatory Pathways, and Retinoid Metabolism to Maintain Limbal Epithelial Cell Homeostasis In Vitro.",2026,10.3390/ijms27041873,https://pubmed.ncbi.nlm.nih.gov/41752009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,41010016,Retinoic Acid-Regulated Epigenetic Marks Identify &lt;i&gt;Alx1&lt;/i&gt; as a Direct Target Gene Required for Optic Cup Formation.,2025,10.3390/genes16091071,https://pubmed.ncbi.nlm.nih.gov/41010016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,41459630,Retinal Pigment Epitheliopathy due to Sub-Optimal Recycling of Vitamin A (RESORVA): A Novel RDH11 -Related Phenotype.,2026,10.1111/cge.70128,https://pubmed.ncbi.nlm.nih.gov/41459630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,42523845,"Transcriptome profiling of ocular surface ectoderm derived from embryonic stem cells, and identification of CACNG6 and AQP3 as its surface markers.",2026,10.18240/ijo.2026.08.02,https://pubmed.ncbi.nlm.nih.gov/42523845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,39180753,Retinol dehydrogenase 10 promotes epithelial-mesenchymal transition in spinal cord gliomas via PI3K/AKT pathway.,2024,10.1177/03946320241276336,https://pubmed.ncbi.nlm.nih.gov/39180753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,42282918,Altered miRNA cargo of endometrial extracellular vesicles in patients with endometriosis: potential implications for pregnancy outcomes.,2026,10.1093/hropen/hoag040,https://pubmed.ncbi.nlm.nih.gov/42282918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,40332443,"Effect of MiRNA 204-5P Mimics and Lipopolysaccharide-Induced Inflammation on Transcription Factor Levels, Cell Maintenance, and Retinoic Acid Signaling in Primary Limbal Epithelial Cells.",2025,10.3390/ijms26083809,https://pubmed.ncbi.nlm.nih.gov/40332443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,39465792,Identification of prognostic biomarkers related to retinoic acid metabolism in gliomas and analysis of their impact on the immune microenvironment.,2024,10.1097/md.0000000000039836,https://pubmed.ncbi.nlm.nih.gov/39465792/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,38691186,Retinoic acid mitigates the NSC319726-induced spermatogenesis dysfunction through cuproptosis-independent mechanisms.,2024,10.1007/s10565-024-09857-6,https://pubmed.ncbi.nlm.nih.gov/38691186/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,39925846,Identification of retinol dehydrogenase 10 as a shared biomarker for metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus.,2025,10.3389/fphar.2025.1521416,https://pubmed.ncbi.nlm.nih.gov/39925846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,41194821,Targeting Angiogenesis and Visual Cycle in Age-Related Macular Degeneration: The Role of Stem Cells and Vinpocetine.,2025,10.7759/cureus.93878,https://pubmed.ncbi.nlm.nih.gov/41194821/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,42336808,"Insights Into the Toxic Effects of 3-Monochloropropane-1,2-Diol on Sertoli Cells via Tandem Mass Tagging Proteomics.",2026,10.1002/jat.70299,https://pubmed.ncbi.nlm.nih.gov/42336808/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,39870430,Early retinoic acid signaling organizes the body axis and defines domains for the forelimb and eye.,2025,10.1016/bs.ctdb.2024.10.002,https://pubmed.ncbi.nlm.nih.gov/39870430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,40053130,Transcriptome analysis of the hypothalamus and testes in Brandt's Vole: new insights into mechanisms of photoperiodic plasticity in postnatal testicular development.,2025,10.1007/s10142-025-01562-9,https://pubmed.ncbi.nlm.nih.gov/40053130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,37923224,Heat Stress Impairs Male Reproductive System with Potential Disruption of Retinol Metabolism and Microbial Balance in the Testis of Mice.,2023,10.1016/j.tjnut.2023.10.017,https://pubmed.ncbi.nlm.nih.gov/37923224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,42055722,Mechanical Overload-Induced Retinoid Metabolism Is Involved in Protein Synthesis in Skeletal Muscle of Female Mice.,2026,10.3177/jnsv.72.176,https://pubmed.ncbi.nlm.nih.gov/42055722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,40889457,Erucic acid impairs male fertility by suppressing retinoic acid synthesis in sertoli cells.,2025,10.1016/j.ecoenv.2025.118971,https://pubmed.ncbi.nlm.nih.gov/40889457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,40535799,Retinoic acid metabolism related gene CYP26B1 promotes tumor stemness and tumor microenvironment remodeling in bladder cancer.,2025,10.7150/jca.101406,https://pubmed.ncbi.nlm.nih.gov/40535799/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,35844620,T Cell-Intrinsic Vitamin A Metabolism and Its Signaling Are Targets for Memory T Cell-Based Cancer Immunotherapy.,2022,10.3389/fimmu.2022.935465,https://pubmed.ncbi.nlm.nih.gov/35844620/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,39167321,atRA Attenuates High Salt-Driven EAE Mainly Through Suppressing Th17-Like Regulatory T Cell Response Mediated by the Inhibition of IL-23R Signaling Pathway.,2025,10.1007/s10753-024-02130-2,https://pubmed.ncbi.nlm.nih.gov/39167321/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,41153933,"Interactive Effects of Vitamin A and All-Trans Retinoic Acid on Growth Performance, Intestinal Health, and Plasma Metabolomics of Broiler Chickens.",2025,10.3390/ani15203005,https://pubmed.ncbi.nlm.nih.gov/41153933/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,34419449,Retinoic acid exerts sexually dimorphic effects on muscle energy metabolism and function.,2021,10.1016/j.jbc.2021.101101,https://pubmed.ncbi.nlm.nih.gov/34419449/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,40634958,In vivo CRISPR screening identifies POU3F3 as a novel regulator of ferroptosis resistance in hepatocellular carcinoma via retinoic acid signaling.,2025,10.1186/s12964-025-02285-x,https://pubmed.ncbi.nlm.nih.gov/40634958/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,29321172,Modest Decreases in Endogenous All-trans-Retinoic Acid Produced by a Mouse Rdh10 Heterozygote Provoke Major Abnormalities in Adipogenesis and Lipid Metabolism.,2018,10.2337/db17-0946,https://pubmed.ncbi.nlm.nih.gov/29321172/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,36979822,Novel Potential Markers of Myofibroblast Differentiation Revealed by Single-Cell RNA Sequencing Analysis of Mesenchymal Stromal Cells in Profibrotic and Adipogenic Conditions.,2023,10.3390/biomedicines11030840,https://pubmed.ncbi.nlm.nih.gov/36979822/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,32359649,Post-natal all-trans-retinoic acid biosynthesis.,2020,10.1016/bs.mie.2020.02.003,https://pubmed.ncbi.nlm.nih.gov/32359649/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,28207193,New insights and changing paradigms in the regulation of vitamin A metabolism in development.,2017,10.1002/wdev.264,https://pubmed.ncbi.nlm.nih.gov/28207193/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,34440306,Upregulation of 15 Antisense Long Non-Coding RNAs in Osteosarcoma.,2021,10.3390/genes12081132,https://pubmed.ncbi.nlm.nih.gov/34440306/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,34687254,A retinoic acid receptor β2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes.,2022,10.1002/biof.1794,https://pubmed.ncbi.nlm.nih.gov/34687254/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,23833249,"RDH10, RALDH2, and CRABP2 are required components of PPARγ-directed ATRA synthesis and signaling in human dendritic cells.",2013,10.1194/jlr.m038984,https://pubmed.ncbi.nlm.nih.gov/23833249/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,23155051,The retinol dehydrogenase Rdh10 localizes to lipid droplets during acyl ester biosynthesis.,2013,10.1074/jbc.m112.402883,https://pubmed.ncbi.nlm.nih.gov/23155051/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,24733397,The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis.,2014,10.1074/jbc.m114.552257,https://pubmed.ncbi.nlm.nih.gov/24733397/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,14596915,Genomic organization and transcription of the human retinol dehydrogenase 10 (RDH10) gene.,2003,10.1016/s0014-5793(03)01089-5,https://pubmed.ncbi.nlm.nih.gov/14596915/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RDH10,ENSG00000121039,Unsafe,12407145,Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE.,2002,,https://pubmed.ncbi.nlm.nih.gov/12407145/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,41168699,Compound heterozygous REC114 variants in dizygotic twins causes meiotic arrest and non-obstructive azoospermia.,2025,10.1186/s12610-025-00291-0,https://pubmed.ncbi.nlm.nih.gov/41168699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,41828362,Genetic Mutations and Non-Genomic Dysregulation in Human Preimplantation Embryo Arrest.,2026,10.3390/ijms27052135,https://pubmed.ncbi.nlm.nih.gov/41828362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,37976262,Essential roles of the ANKRD31-REC114 interaction in meiotic recombination and mouse spermatogenesis.,2023,10.1073/pnas.2310951120,https://pubmed.ncbi.nlm.nih.gov/37976262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,40442410,Genetic and functional analysis reveals novel mutations in meiotic genes underlying non-obstructive azoospermia.,2025,10.1007/s10815-025-03505-6,https://pubmed.ncbi.nlm.nih.gov/40442410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,41946721,Recruitment of Mre11 to recombination sites during meiosis.,2026,10.1038/s41467-026-71310-5,https://pubmed.ncbi.nlm.nih.gov/41946721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,38148155,A bi-allelic REC114 loss-of-function variant causes meiotic arrest and nonobstructive azoospermia.,2024,10.1111/cge.14473,https://pubmed.ncbi.nlm.nih.gov/38148155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,42221552,Meiotic gene variants contribute to recurrent blastulation failure.,2026,10.1093/hropen/hoag039,https://pubmed.ncbi.nlm.nih.gov/42221552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,36967403,The RNA-binding protein FUS/TLS interacts with SPO11 and PRDM9 and localize at meiotic recombination hotspots.,2023,10.1007/s00018-023-04744-5,https://pubmed.ncbi.nlm.nih.gov/36967403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,37442581,Evolutionary conservation of the structure and function of meiotic Rec114-Mei4 and Mer2 complexes.,2023,10.1101/gad.350462.123,https://pubmed.ncbi.nlm.nih.gov/37442581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,41706353,A common cause of non-obstructive azoospermia: biallelic MEI1 variants and implications for infertility diagnostics.,2026,10.1007/s10815-026-03807-3,https://pubmed.ncbi.nlm.nih.gov/41706353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,41419020,MEI4 variations drive female reproductive disorders via impaired oocyte abundance and developmental potential.,2026,10.1016/j.jgg.2025.12.005,https://pubmed.ncbi.nlm.nih.gov/41419020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,36396648,TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks.,2022,10.1038/s41467-022-34799-0,https://pubmed.ncbi.nlm.nih.gov/36396648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,37431931,Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation.,2023,10.15252/embj.2023113866,https://pubmed.ncbi.nlm.nih.gov/37431931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,40515540,An Increase in Male Recombination Rate With Age in Dairy Cattle Is Heritable and Polygenic.,2026,10.1111/jbg.12948,https://pubmed.ncbi.nlm.nih.gov/40515540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,37442580,Structure and DNA-bridging activity of the essential Rec114-Mei4 trimer interface.,2023,10.1101/gad.350461.123,https://pubmed.ncbi.nlm.nih.gov/37442580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,31003867,"REC114 Partner ANKRD31 Controls Number, Timing, and Location of Meiotic DNA Breaks.",2019,10.1016/j.molcel.2019.03.023,https://pubmed.ncbi.nlm.nih.gov/31003867/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,35489071,SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination.,2022,10.1093/nar/gkac304,https://pubmed.ncbi.nlm.nih.gov/35489071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,30569039,Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4.,2018,10.26508/lsa.201800259,https://pubmed.ncbi.nlm.nih.gov/30569039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,32494071,Multilayered mechanisms ensure that short chromosomes recombine in meiosis.,2020,10.1038/s41586-020-2248-2,https://pubmed.ncbi.nlm.nih.gov/32494071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,32290544,Genetic Interactions of Histone Modification Machinery Set1 and PAF1C with the Recombination Complex Rec114-Mer2-Mei4 in the Formation of Meiotic DNA Double-Strand Breaks.,2020,10.3390/ijms21082679,https://pubmed.ncbi.nlm.nih.gov/32290544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,23550131,Trans-Lesion DNA Polymerases May Be Involved in Yeast Meiosis.,2013,10.1534/g3.113.005603,https://pubmed.ncbi.nlm.nih.gov/23550131/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REC114,ENSG00000183324,Unsafe,2060778,Isolation of mutants defective in early steps of meiotic recombination in the yeast Saccharomyces cerevisiae.,1991,10.1093/genetics/128.1.79,https://pubmed.ncbi.nlm.nih.gov/2060778/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,42627827,Macrophages diverge into profibrotic SAMs and proresolving ReM2 cells to regulate liver fibrosis.,2026,10.1073/pnas.2611441123,https://pubmed.ncbi.nlm.nih.gov/42627827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,41454932,Targeting EGFR-REM2-Ca&lt;sup&gt;2+&lt;/sup&gt; signaling and LDHA: amphiregulin remodels energy metabolism to enhance aged embryo development.,2025,10.1007/s00018-025-06037-5,https://pubmed.ncbi.nlm.nih.gov/41454932/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,40839369,SIRT6 Is a Key Regulator of Pancreatic β-Cell Survival and Function During Aging.,2025,10.2337/db25-0116,https://pubmed.ncbi.nlm.nih.gov/40839369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,38995900,Rem2 interacts with CaMKII at synapses and restricts long-term potentiation in hippocampus.,2024,10.1371/journal.pone.0301063,https://pubmed.ncbi.nlm.nih.gov/38995900/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,38978817,"The evolution of mammalian Rem2: unraveling the impact of purifying selection and coevolution on protein function, and implications for human disorders.",2024,10.3389/fbinf.2024.1381540,https://pubmed.ncbi.nlm.nih.gov/38978817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,41367385,Decoding the peripheral transcriptomic and meta-genomic response to music in autism spectrum disorder via saliva-based RNA sequencing.,2025,10.3389/fmolb.2025.1696704,https://pubmed.ncbi.nlm.nih.gov/41367385/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,40004183,Mining of Root-Specific Expression Genes and Their Core Cis-Regulatory Elements in Plants.,2025,10.3390/ijms26041720,https://pubmed.ncbi.nlm.nih.gov/40004183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,39336722,Genetic Foundations of Nellore Traits: A Gene Prioritization and Functional Analyses of Genome-Wide Association Study Results.,2024,10.3390/genes15091131,https://pubmed.ncbi.nlm.nih.gov/39336722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,37654674,Inactivation influences the extent of inhibition of voltage-gated Ca+2 channels by Gem-implications for channelopathies.,2023,10.3389/fphys.2023.1155976,https://pubmed.ncbi.nlm.nih.gov/37654674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,34261001,Into the spotlight: RGK proteins in skeletal muscle.,2021,10.1016/j.ceca.2021.102439,https://pubmed.ncbi.nlm.nih.gov/34261001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,39870623,Flow chemistry-enabled asymmetric synthesis of cyproterone acetate in a chemo-biocatalytic approach.,2025,10.1038/s41467-025-56371-2,https://pubmed.ncbi.nlm.nih.gov/39870623/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,30072381,The Ras-like GTPase Rem2 is a potent inhibitor of calcium/calmodulin-dependent kinase II activity.,2018,10.1074/jbc.ra118.003560,https://pubmed.ncbi.nlm.nih.gov/30072381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,29809135,Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits.,2018,10.7554/elife.33092,https://pubmed.ncbi.nlm.nih.gov/29809135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,30254571,Cre-Recombinase Dependent Germline Deletion of a Conditional Allele in the Rgs9cre Mouse Line.,2018,10.3389/fncir.2018.00068,https://pubmed.ncbi.nlm.nih.gov/30254571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,27600327,Localization of rem2 in the central nervous system of the adult rainbow trout (Oncorhynchus mykiss).,2016,10.1016/j.jchemneu.2016.09.001,https://pubmed.ncbi.nlm.nih.gov/27600327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,27118437,"Rem2, a member of the RGK family of small GTPases, is enriched in nuclei of the basal ganglia.",2016,10.1038/srep25137,https://pubmed.ncbi.nlm.nih.gov/27118437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,32669356,Experience-Dependent Development of Dendritic Arbors in Mouse Visual Cortex.,2020,10.1523/jneurosci.2910-19.2020,https://pubmed.ncbi.nlm.nih.gov/32669356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,29066292,Rem2 signaling affects neuronal structure and function in part by regulation of gene expression.,2017,10.1016/j.mcn.2017.10.004,https://pubmed.ncbi.nlm.nih.gov/29066292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,30980111,The role of the protein-RNA recognition code in neurodegeneration.,2019,10.1007/s00018-019-03096-3,https://pubmed.ncbi.nlm.nih.gov/30980111/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,32104913,Designer genetically encoded voltage-dependent calcium channel inhibitors inspired by RGK GTPases.,2020,10.1113/jp276544,https://pubmed.ncbi.nlm.nih.gov/32104913/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,27039097,Scaling exponent values as an ordinary function of the ratio of very low frequency to high frequency powers in heart rate variability over various sleep stages.,2016,10.1007/s11325-016-1320-5,https://pubmed.ncbi.nlm.nih.gov/27039097/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,30908497,Head cooling during sleep improves sleep quality in the luteal phase in female university students: A randomized crossover-controlled pilot study.,2019,10.1371/journal.pone.0213706,https://pubmed.ncbi.nlm.nih.gov/30908497/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,25576452,RGK regulation of voltage-gated calcium channels.,2015,10.1007/s11427-014-4788-x,https://pubmed.ncbi.nlm.nih.gov/25576452/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,8315433,Autologous marrow transplantation for patients with acute myeloid leukemia in untreated first relapse or in second complete remission.,1993,10.1200/jco.1993.11.7.1353,https://pubmed.ncbi.nlm.nih.gov/8315433/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,18786617,Transcriptome analysis identifies genes with enriched expression in the mouse central extended amygdala.,2008,10.1016/j.neuroscience.2008.07.070,https://pubmed.ncbi.nlm.nih.gov/18786617/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REM2,ENSG00000139890,Unsafe,14701738,Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity.,2004,10.1128/mcb.24.2.651-661.2004,https://pubmed.ncbi.nlm.nih.gov/14701738/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REXO5,ENSG00000005189,Unsafe,42761548,Molecular characterization of normal and physiologically suppressed human parathyroid glands at single-cell resolution.,2026,10.1210/jendso/bvag133,https://pubmed.ncbi.nlm.nih.gov/42761548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REXO5,ENSG00000005189,Unsafe,39080354,REXO5 promotes genomic integrity through regulating R-loop using its exonuclease activity.,2024,10.1038/s41375-024-02362-z,https://pubmed.ncbi.nlm.nih.gov/39080354/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REXO5,ENSG00000005189,Unsafe,40455837,Conserved domains and structural motifs that differentiate closely related Rex1 and Rex3 DEDDh exoribonucleases are required for their function in yeast.,2025,10.1371/journal.pone.0321120,https://pubmed.ncbi.nlm.nih.gov/40455837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REXO5,ENSG00000005189,Unsafe,29045842,"The Conserved RNA Exonuclease Rexo5 Is Required for 3' End Maturation of 28S rRNA, 5S rRNA, and snoRNAs.",2017,10.1016/j.celrep.2017.09.067,https://pubmed.ncbi.nlm.nih.gov/29045842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
REXO5,ENSG00000005189,Unsafe,28539487,Characterization of the mammalian RNA exonuclease 5/NEF-sp as a testis-specific nuclear 3' → 5' exoribonuclease.,2017,10.1261/rna.060723.117,https://pubmed.ncbi.nlm.nih.gov/28539487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFESD,ENSG00000175449,Unsafe,40694934,Gonadal sex differentiation in Eleutheronema tetradactylum: Histological features and transcriptomic insights from mature gonads.,2025,10.1016/j.cbd.2025.101586,https://pubmed.ncbi.nlm.nih.gov/40694934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFESD,ENSG00000175449,Unsafe,35681134,Novel γδ T cell-based prognostic signature to estimate risk and aid therapy in hepatocellular carcinoma.,2022,10.1186/s12885-022-09662-6,https://pubmed.ncbi.nlm.nih.gov/35681134/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFESD,ENSG00000175449,Unsafe,33159718,Expression Changes in Epigenetic Gene Pathways Associated With One-Carbon Nutritional Metabolites in Maternal Blood From Pregnancies Resulting in Autism and Non-Typical Neurodevelopment.,2021,10.1002/aur.2428,https://pubmed.ncbi.nlm.nih.gov/33159718/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,42677697,A retinoic acid-Rfx6 cascade modulates Wnt/Bmp-dependent gut tube patterning: insight into the molecular basis of Mitchell-Riley Syndrome.,2026,10.1242/dev.205552,https://pubmed.ncbi.nlm.nih.gov/42677697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,41422049,Multifaceted functions of transcription regulatory factor X6 (RFX6): from pancreatic development to cancer progression.,2025,10.1186/s12935-025-04073-6,https://pubmed.ncbi.nlm.nih.gov/41422049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,41716817,RFX6 expression is central to the development and function of the neuroendocrine compartments of the pancreas and intestine and strongly affects diabetes risk.,2026,10.1007/s13340-025-00867-1,https://pubmed.ncbi.nlm.nih.gov/41716817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,41636221,RFX6 maturity-onset diabetes of the young: clinical considerations and novel use of tirzepatide.,2026,10.1530/edm-25-0142,https://pubmed.ncbi.nlm.nih.gov/41636221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,41798991,Mechanisms inducing differentiation of adult islet progenitor-like cells into functional islet-like organoids.,2026,10.3389/frtra.2026.1740314,https://pubmed.ncbi.nlm.nih.gov/41798991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,38587174,RFX6 regulates human intestinal patterning and function upstream of PDX1.,2024,10.1242/dev.202529,https://pubmed.ncbi.nlm.nih.gov/38587174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,38932472,An Inherited Allele Confers Prostate Cancer Progression and Drug Resistance via RFX6/HOXA10-Orchestrated TGFβ Signaling.,2024,10.1002/advs.202401492,https://pubmed.ncbi.nlm.nih.gov/38932472/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,40761211,RFX6 heterozygous frame-shift variation causes maturity-onset diabetes mellitus of the young (MODY) with refractory hyperlipidemia: a case report.,2025,10.21037/acr-24-266,https://pubmed.ncbi.nlm.nih.gov/40761211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,39359667,Initial clinical manifestations in a young male with RFX6-variant-associated diabetes.,2024,10.1297/cpe.2024-0016,https://pubmed.ncbi.nlm.nih.gov/39359667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,39080045,"Deletion of RFX6 impairs iPSC-derived islet organoid development and survival, with no impact on PDX1+/NKX6.1+ progenitors.",2024,10.1007/s00125-024-06232-2,https://pubmed.ncbi.nlm.nih.gov/39080045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,39318439,Partial Lipodystrophy Affecting the Extremities in a Young Woman With Autoimmune Polyglandular Syndrome 1.,2024,10.1210/jcemcr/luae166,https://pubmed.ncbi.nlm.nih.gov/39318439/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,38743124,RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function.,2024,10.1007/s00125-024-06163-y,https://pubmed.ncbi.nlm.nih.gov/38743124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,38093528,RFX6 facilitates aerobic glycolysis-mediated growth and metastasis of hepatocellular carcinoma through targeting PGAM1.,2023,10.1002/ctm2.1511,https://pubmed.ncbi.nlm.nih.gov/38093528/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,38239755,Human RFX6 regulates endoderm patterning at the primitive gut tube stage.,2024,10.1093/pnasnexus/pgae001,https://pubmed.ncbi.nlm.nih.gov/38239755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,38064570,RFX6 Maintains Gene Expression and Function of Adult Human Islet α-Cells.,2024,10.2337/db23-0483,https://pubmed.ncbi.nlm.nih.gov/38064570/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,38049589,Genetic risk converges on regulatory networks mediating early type 2 diabetes.,2023,10.1038/s41586-023-06693-2,https://pubmed.ncbi.nlm.nih.gov/38049589/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,41175096,"Population Prevalence, Penetrance, and Mortality for Genetically Confirmed MODY.",2026,10.1210/clinem/dgaf599,https://pubmed.ncbi.nlm.nih.gov/41175096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,42559753,Glycemic and Renal Effects of SGLT2 Inhibitors in Monogenic Diabetes: A Real-World National Study.,2026,10.1111/dom.71169,https://pubmed.ncbi.nlm.nih.gov/42559753/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,39170430,Pan-cancer investigation of RFX family and associated genes identifies RFX8 as a therapeutic target in leukemia.,2024,10.1016/j.heliyon.2024.e35368,https://pubmed.ncbi.nlm.nih.gov/39170430/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,39003281,PDX1+ cell budding morphogenesis in a stem cell-derived islet spheroid system.,2024,10.1038/s41467-024-50109-2,https://pubmed.ncbi.nlm.nih.gov/39003281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,34988028,Inhibition of RFX6 Suppresses the Invasive Ability of Tumor Cells Through the Notch Pathway and Affects Tumor Immunity in Hepatocellular Carcinoma.,2021,10.3389/fonc.2021.801222,https://pubmed.ncbi.nlm.nih.gov/34988028/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,35402865,Calcineurin/NFATc2 and PI3K/AKT signaling maintains β-cell identity and function during metabolic and inflammatory stress.,2022,10.1016/j.isci.2022.104125,https://pubmed.ncbi.nlm.nih.gov/35402865/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,39364395,Whole Exome Sequencing in Children With Type 1 Diabetes Before Age 6 Years Reveals Insights Into Disease Heterogeneity.,2024,10.1155/2024/3076895,https://pubmed.ncbi.nlm.nih.gov/39364395/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,37550764,GATA2 co-opts TGFβ1/SMAD4 oncogenic signaling and inherited variants at 6q22 to modulate prostate cancer progression.,2023,10.1186/s13046-023-02745-7,https://pubmed.ncbi.nlm.nih.gov/37550764/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,32410729,"Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq.",2020,10.7554/elife.55053,https://pubmed.ncbi.nlm.nih.gov/32410729/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,32462000,Identification and Validation of Prognostically Relevant Gene Signature in Melanoma.,2020,10.1155/2020/5323614,https://pubmed.ncbi.nlm.nih.gov/32462000/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,36418577,Identification of monogenic variants in more than ten per cent of children without type 1 diabetes-related autoantibodies at diagnosis in the Finnish Pediatric Diabetes Register.,2023,10.1007/s00125-022-05834-y,https://pubmed.ncbi.nlm.nih.gov/36418577/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,27166427,Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells.,2016,10.1038/srep25765,https://pubmed.ncbi.nlm.nih.gov/27166427/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,29396371,Genome-wide analysis of PDX1 target genes in human pancreatic progenitors.,2018,10.1016/j.molmet.2018.01.011,https://pubmed.ncbi.nlm.nih.gov/29396371/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,24940737,Contribution of a non-β-cell source to β-cell mass during pregnancy.,2014,10.1371/journal.pone.0100398,https://pubmed.ncbi.nlm.nih.gov/24940737/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,25497100,RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells.,2014,10.1016/j.celrep.2014.11.010,https://pubmed.ncbi.nlm.nih.gov/25497100/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX6,ENSG00000185002,Unsafe,20148032,Rfx6 directs islet formation and insulin production in mice and humans.,2010,10.1038/nature08748,https://pubmed.ncbi.nlm.nih.gov/20148032/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,42206447,Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma.,2026,10.1002/advs.202523792,https://pubmed.ncbi.nlm.nih.gov/42206447/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,42899520,METTL3 destabilizes RFX7 to ameliorate PDGF-BB-induced airway smooth muscle cell dysfunction and inflammation in an in vitro model of childhood asthma.,2026,10.1080/02770903.2026.2751839,https://pubmed.ncbi.nlm.nih.gov/42899520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,42225953,Regulatory factor X 7 limits Myc activity during B cell activation and suppresses Myc-dependent lymphomagenesis.,2026,10.1038/s41590-026-02526-2,https://pubmed.ncbi.nlm.nih.gov/42225953/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,41888523,The protein kinase DYRK1B is a p53 target gene and functions as a negative feedback regulator of the transcription factor RFX7.,2026,10.1038/s41419-026-08660-x,https://pubmed.ncbi.nlm.nih.gov/41888523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,41940035,Macrophage Polarization-Related Biomarkers in Epilepsy: Integrated Bioinformatics Analysis and Clinical Validation.,2026,10.2147/jir.s581430,https://pubmed.ncbi.nlm.nih.gov/41940035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,40134574,Suppression of regulatory factor X 7 alleviates airway remodeling and inflammation in childhood asthma.,2025,10.25259/cytojournal_138_2024,https://pubmed.ncbi.nlm.nih.gov/40134574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,39007708,Expanding the clinical phenotype and variant spectrum associated with RFX7.,2024,10.1002/ajmg.a.63816,https://pubmed.ncbi.nlm.nih.gov/39007708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,39155648,A variant in long noncoding RNA NORSF affects granulosa cells response to transcription factor RFX7.,2024,10.1002/jcp.31414,https://pubmed.ncbi.nlm.nih.gov/39155648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,39181888,p53 target ANKRA2 cooperates with RFX7 to regulate tumor suppressor genes.,2024,10.1038/s41420-024-02149-2,https://pubmed.ncbi.nlm.nih.gov/39181888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,39085113,Regulatory factor X7 Represses Ox-LDL-Induced Proliferation and Migration of VSMCs via SIRT4-Mediated Inactivation of JAK2/STAT3 Pathway.,2024,10.1536/ihj.23-631,https://pubmed.ncbi.nlm.nih.gov/39085113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,36753521,Human cytomegalovirus pUL97 upregulates SOCS3 expression via transcription factor RFX7 in neural progenitor cells.,2023,10.1371/journal.ppat.1011166,https://pubmed.ncbi.nlm.nih.gov/36753521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,36864036,Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes.,2023,10.1038/s41420-023-01378-1,https://pubmed.ncbi.nlm.nih.gov/36864036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,36334883,Phenotype expansion and neurological manifestations of neurobehavioural disease caused by a variant in RFX7.,2023,10.1016/j.ejmg.2022.104657,https://pubmed.ncbi.nlm.nih.gov/36334883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,34197623,Transcription factor RFX7 governs a tumor suppressor network in response to p53 and stress.,2021,10.1093/nar/gkab575,https://pubmed.ncbi.nlm.nih.gov/34197623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,36045400,Identification of RFX5 as prognostic biomarker and associated with immune infiltration in stomach adenocarcinoma.,2022,10.1186/s40001-022-00794-w,https://pubmed.ncbi.nlm.nih.gov/36045400/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,35831154,Hsa_circ_0030042 Ameliorates Oxidized Low-Density Lipoprotein-Induced Endothelial Cell Injury via the MiR-616-3p/RFX7 Axis.,2022,10.1536/ihj.22-065,https://pubmed.ncbi.nlm.nih.gov/35831154/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,38661126,Elucidating the chain of command: our current understanding of critical target genes for p53-mediated tumor suppression.,2024,10.1080/10409238.2024.2344465,https://pubmed.ncbi.nlm.nih.gov/38661126/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,33658631,"Disruption of RFX family transcription factors causes autism, attention-deficit/hyperactivity disorder, intellectual disability, and dysregulated behavior.",2021,10.1038/s41436-021-01114-z,https://pubmed.ncbi.nlm.nih.gov/33658631/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,34907345,p53-mediated AKT and mTOR inhibition requires RFX7 and DDIT4 and depends on nutrient abundance.,2022,10.1038/s41388-021-02147-z,https://pubmed.ncbi.nlm.nih.gov/34907345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,35986039,Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants.,2022,10.1038/s41598-022-18296-4,https://pubmed.ncbi.nlm.nih.gov/35986039/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,29967452,The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity.,2018,10.1038/s41590-018-0144-9,https://pubmed.ncbi.nlm.nih.gov/29967452/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,37657555,Enterovirus D68 infection upregulates SOCS3 expression to inhibit JAK-STAT3 signaling and antagonize the innate interferon response of the host.,2023,10.1016/j.virs.2023.08.007,https://pubmed.ncbi.nlm.nih.gov/37657555/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,35795532,Immune Infiltration of Ulcerative Colitis and Detection of the m6A Subtype.,2022,10.1155/2022/7280977,https://pubmed.ncbi.nlm.nih.gov/35795532/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,33847741,Deciphering the mechanisms of CC-122 resistance in DLBCL via a genome-wide CRISPR screen.,2021,10.1182/bloodadvances.2020003431,https://pubmed.ncbi.nlm.nih.gov/33847741/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,28063705,H9N2 avian influenza virus enhances the immune responses of BMDCs by down-regulating miR29c.,2017,10.1016/j.vaccine.2016.12.054,https://pubmed.ncbi.nlm.nih.gov/28063705/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,30926791,PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice.,2019,10.1038/s41467-019-09180-3,https://pubmed.ncbi.nlm.nih.gov/30926791/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,28539126,Knowledge-driven binning approach for rare variant association analysis: application to neuroimaging biomarkers in Alzheimer's disease.,2017,10.1186/s12911-017-0454-0,https://pubmed.ncbi.nlm.nih.gov/28539126/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,20946665,A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer.,2010,10.1186/bcr2753,https://pubmed.ncbi.nlm.nih.gov/20946665/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX7,ENSG00000181827,Unsafe,18673564,Identification and characterization of novel human tissue-specific RFX transcription factors.,2008,10.1186/1471-2148-8-226,https://pubmed.ncbi.nlm.nih.gov/18673564/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX8,ENSG00000196460,Unsafe,39170430,Pan-cancer investigation of RFX family and associated genes identifies RFX8 as a therapeutic target in leukemia.,2024,10.1016/j.heliyon.2024.e35368,https://pubmed.ncbi.nlm.nih.gov/39170430/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX8,ENSG00000196460,Unsafe,39974400,Establishment and validation of predictive models by mutational and transcriptional factors for the prognosis of stage IV colorectal cancer patients with liver metastasis who undergo palliative surgery on primary tumors.,2025,10.21037/tcr-24-1183,https://pubmed.ncbi.nlm.nih.gov/39974400/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX8,ENSG00000196460,Unsafe,38350390,Identification of candidate genes affecting the tibia quality in Nonghua duck.,2024,10.1016/j.psj.2024.103515,https://pubmed.ncbi.nlm.nih.gov/38350390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX8,ENSG00000196460,Unsafe,36980830,Effect of Dietetic Obesity on Testicular Transcriptome in Cynomolgus Monkeys.,2023,10.3390/genes14030557,https://pubmed.ncbi.nlm.nih.gov/36980830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX8,ENSG00000196460,Unsafe,36045400,Identification of RFX5 as prognostic biomarker and associated with immune infiltration in stomach adenocarcinoma.,2022,10.1186/s40001-022-00794-w,https://pubmed.ncbi.nlm.nih.gov/36045400/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX8,ENSG00000196460,Unsafe,35763670,RNA Helicase DDX24 Stabilizes LAMB1 to Promote Hepatocellular Carcinoma Progression.,2022,10.1158/0008-5472.can-21-3748,https://pubmed.ncbi.nlm.nih.gov/35763670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX8,ENSG00000196460,Unsafe,29510665,Characterization of the human RFX transcription factor family by regulatory and target gene analysis.,2018,10.1186/s12864-018-4564-6,https://pubmed.ncbi.nlm.nih.gov/29510665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX8,ENSG00000196460,Unsafe,35222524,Prognostic Model of Eleven Genes Based on the Immune Microenvironment in Patients With Thymoma.,2022,10.3389/fgene.2022.668696,https://pubmed.ncbi.nlm.nih.gov/35222524/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX8,ENSG00000196460,Unsafe,34368281,"Genome-Wide Association Studies Reveal Neurological Genes for Dog Herding, Predation, Temperament, and Trainability Traits.",2021,10.3389/fvets.2021.693290,https://pubmed.ncbi.nlm.nih.gov/34368281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFX8,ENSG00000196460,Unsafe,33987581,A genome-wide association study (GWAS) for pH value in the meat of Berkshire pigs.,2021,10.5187/jast.2021.e17,https://pubmed.ncbi.nlm.nih.gov/33987581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,41376631,Case Report: A novel CIITA mutation causing MHC class II deficiency: first reported case in Morocco.,2025,10.3389/fimmu.2025.1707772,https://pubmed.ncbi.nlm.nih.gov/41376631/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,42600555,Sparse integrative dictionary learning resolves conserved drug-response states in multiple myeloma (MM).,2026,10.1016/j.cancergen.2026.08.002,https://pubmed.ncbi.nlm.nih.gov/42600555/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,42099591,"Clinical, immunological, treatment characteristics, and outcomes in 22 patients with major histocompatibility complex class II deficiency.",2026,10.3389/fimmu.2026.1811502,https://pubmed.ncbi.nlm.nih.gov/42099591/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,39170430,Pan-cancer investigation of RFX family and associated genes identifies RFX8 as a therapeutic target in leukemia.,2024,10.1016/j.heliyon.2024.e35368,https://pubmed.ncbi.nlm.nih.gov/39170430/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,41112307,Multi-omics analyses inform mechanisms of immunotherapy response in pancreatic cancer.,2025,10.3389/fimmu.2025.1673098,https://pubmed.ncbi.nlm.nih.gov/41112307/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,39192888,Prognostic value of four immune-related genes in lower-grade gliomas: a biomarker discovery study.,2024,10.3389/fgene.2024.1403587,https://pubmed.ncbi.nlm.nih.gov/39192888/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,37604847,The non-classical major histocompatibility complex II protein SLA-DM is crucial for African swine fever virus replication.,2023,10.1038/s41598-023-36788-9,https://pubmed.ncbi.nlm.nih.gov/37604847/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,33093461,Fisetin inhibits proliferation of pancreatic adenocarcinoma by inducing DNA damage via RFXAP/KDM4A-dependent histone H3K36 demethylation.,2020,10.1038/s41419-020-03019-2,https://pubmed.ncbi.nlm.nih.gov/33093461/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,39181888,p53 target ANKRA2 cooperates with RFX7 to regulate tumor suppressor genes.,2024,10.1038/s41420-024-02149-2,https://pubmed.ncbi.nlm.nih.gov/39181888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,39121331,Bioinformatics analysis of the tumor microenvironment in melanoma - Constructing a prognostic model based on CD8+ T cell-related genes: An observational study.,2024,10.1097/md.0000000000038924,https://pubmed.ncbi.nlm.nih.gov/39121331/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,35852466,A CMV-induced adaptive human Vδ1+ γδ T cell clone recognizes HLA-DR.,2022,10.1084/jem.20212525,https://pubmed.ncbi.nlm.nih.gov/35852466/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,38996837,"MHC Class II Deficiency: Clinical, Immunological, and Genetic Insights in a Large Multicenter Cohort.",2024,10.1016/j.jaip.2024.06.046,https://pubmed.ncbi.nlm.nih.gov/38996837/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,34422827,N6-Methyladenosine-Regulated mRNAs: Potential Prognostic Biomarkers for Patients With Lung Adenocarcinoma.,2021,10.3389/fcell.2021.705962,https://pubmed.ncbi.nlm.nih.gov/34422827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,38342661,Explainable cancer factors discovery: Shapley additive explanation for machine learning models demonstrates the best practices in the case of pancreatic cancer.,2024,10.1016/j.pan.2024.02.002,https://pubmed.ncbi.nlm.nih.gov/38342661/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,31870593,Link between CIITA rs3087456 polymorphism and the risk of laryngeal squamous cell carcinoma in a Chinese population.,2020,10.1016/j.prp.2019.152793,https://pubmed.ncbi.nlm.nih.gov/31870593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,37408475,Genomic analysis of venous thrombosis in children with acute lymphoblastic leukemia from diverse ancestries.,2024,10.3324/haematol.2022.281582,https://pubmed.ncbi.nlm.nih.gov/37408475/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,26337469,Pancreatic cancer-derived exosomes transfer miRNAs to dendritic cells and inhibit RFXAP expression via miR-212-3p.,2015,10.18632/oncotarget.4924,https://pubmed.ncbi.nlm.nih.gov/26337469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,32875002,A Novel RFXANK Mutation in a Chinese Child With MHC II Deficiency: Case Report and Literature Review.,2020,10.1093/ofid/ofaa314,https://pubmed.ncbi.nlm.nih.gov/32875002/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,37584719,"Clinical, Immunological, and Genetic Findings in Iranian Patients with MHC-II Deficiency: Confirmation of c.162delG RFXANK Founder Mutation in the Iranian Population.",2023,10.1007/s10875-023-01562-z,https://pubmed.ncbi.nlm.nih.gov/37584719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,29467893,IFN-γ induces the upregulation of RFXAP via inhibition of miR-212-3p in pancreatic cancer cells: A novel mechanism for IFN-γ response.,2018,10.3892/ol.2018.7777,https://pubmed.ncbi.nlm.nih.gov/29467893/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,32351547,Novel Immune-Related Gene Signature for Risk Stratification and Prognosis of Survival in Lower-Grade Glioma.,2020,10.3389/fgene.2020.00363,https://pubmed.ncbi.nlm.nih.gov/32351547/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,33628209,"Clinical, Immunological, and Molecular Features of Severe Combined Immune Deficiency: A Multi-Institutional Experience From India.",2020,10.3389/fimmu.2020.619146,https://pubmed.ncbi.nlm.nih.gov/33628209/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,30170160,MHC-II Deficiency Among Egyptians: Novel Mutations and Unique Phenotypes.,2019,10.1016/j.jaip.2018.07.046,https://pubmed.ncbi.nlm.nih.gov/30170160/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,31922974,Association between variant alleles of major histocompatibility complex class II regulatory genes and nasopharyngeal carcinoma susceptibility.,2020,10.1097/cej.0000000000000563,https://pubmed.ncbi.nlm.nih.gov/31922974/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,29285385,MHC class II associated stomach cancer mutations correlate with lack of subsequent tumor development.,2017,10.3892/mco.2017.1432,https://pubmed.ncbi.nlm.nih.gov/29285385/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,25445815,Association of high CD4-positive T cell infiltration with mutations in HLA class II-regulatory genes in microsatellite-unstable colorectal cancer.,2015,10.1007/s00262-014-1638-4,https://pubmed.ncbi.nlm.nih.gov/25445815/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,20732328,Solution structure of the heterotrimeric complex between the interaction domains of RFX5 and RFXAP from the RFX gene regulatory complex.,2010,10.1016/j.jmb.2010.08.025,https://pubmed.ncbi.nlm.nih.gov/20732328/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RFXAP,ENSG00000133111,Unsafe,28694326,Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E).,2017,10.1182/blood-2017-02-768234,https://pubmed.ncbi.nlm.nih.gov/28694326/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,42468899,RGR-opsin maintains cellular homeostasis by ameliorating the proteotoxicity of its exon-skipping splice variant.,2026,10.1016/j.exer.2026.111125,https://pubmed.ncbi.nlm.nih.gov/42468899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,42455869,Design and in silico validation of donor DNA for RNA-guided recombinase-mediated knockout of mstnb gene in Labeo rohita.,2026,10.1371/journal.pone.0352166,https://pubmed.ncbi.nlm.nih.gov/42455869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,42160018,"Dual Knockout Models of the Spatially and Functionally Conserved rgra and rgrb Zebrafish Genes Reveal the Requirement of RGR for the Integrity of Cone-Mediated Photopic Vision, the Photopic Visual Cycle and Bruch's Membrane Morphology.",2026,10.1096/fj.202504935r,https://pubmed.ncbi.nlm.nih.gov/42160018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,42192905,Association of Iba1-Positive Macrophages and B7-H3-Positive Tumor Cells with Tumor Growth Kinetics in WHO Grade II Meningioma: A Pilot Watch-and-Wait Cohort Study.,2026,10.3390/cancers18101545,https://pubmed.ncbi.nlm.nih.gov/42192905/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,42122870,Plant Silicon Defences Suppress Herbivore Growth but Trigger Compensatory Feeding in a Moderate-Accumulating Grass.,2026,10.3390/plants15091380,https://pubmed.ncbi.nlm.nih.gov/42122870/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,41515550,"Clarifying the Clinical Utility of NTAR/RGR for PAH and CTEPH. Comment on Iancu et al. Evaluating NT-proBNP-to-Albumin (NTAR) and RDW-to-eGFR (RGR) Ratios as Biomarkers for Predicting Hospitalization Duration and Mortality in Pulmonary Arterial Hypertension (PAH) and Chronic Thromboembolic Pulmonary Hypertension (CTEPH). &lt;i&gt;Diagnostics&lt;/i&gt; 2025, &lt;i&gt;15&lt;/i&gt;, 2126.",2025,10.3390/diagnostics16010055,https://pubmed.ncbi.nlm.nih.gov/41515550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,42514582,Arbuscular Mycorrhiza Fungi Reduce Photosystem II Efficiency in Phosphorus-Deficient Maize Without Promoting Growth.,2026,10.3390/plants15142215,https://pubmed.ncbi.nlm.nih.gov/42514582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,41775632,RGR-Mediated Photopic Visual Cycle and Oxidative Stress: Potential Mechanisms for Cone Vision Impairment and Retinal Degeneration in Retinitis Pigmentosa Linked to D1080N-IRBP.,2026,10.1523/jneurosci.1924-25.2026,https://pubmed.ncbi.nlm.nih.gov/41775632/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,37883094,Proteopathy Linked to Exon-Skipping Isoform of RGR-Opsin Contributes to the Pathogenesis of Age-Related Macular Degeneration.,2023,10.1167/iovs.64.13.41,https://pubmed.ncbi.nlm.nih.gov/37883094/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,41587916,Vectorized ULK1/2 and VPS34 Inhibitors for Tissue-Selective Autophagy Inhibition in Oncology.,2026,10.1021/acs.jmedchem.5c00997,https://pubmed.ncbi.nlm.nih.gov/41587916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,41450801,Comparative evaluation of coronally positioned flap with prereacted glass ionomer (Giomer) and zirconia-reinfused glass ionomer (Zirconomer) in the treatment of gingival recession incidental with non-carious cervical lesions: A randomized clinical trial.,2025,10.4103/jisp.jisp_238_23,https://pubmed.ncbi.nlm.nih.gov/41450801/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,39467145,Retinal G-protein-coupled receptor deletion exacerbates AMD-like changes via the PINK1-parkin pathway under oxidative stress.,2024,10.1096/fj.202401160rr,https://pubmed.ncbi.nlm.nih.gov/39467145/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,42207362,"A comparative analysis of serum biochemistry, gene expression, and gut microbiota in domestication-susceptible and domestication-resistant mandarin fish (Siniperca chuatsi).",2026,10.1007/s10695-026-01709-w,https://pubmed.ncbi.nlm.nih.gov/42207362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,40283684,Prognostic Value of the Red Cell Distribution Width-to-eGFR Ratio (RGR) Across Chronic Heart Failure Phenotypes: A Retrospective Observational Pilot Study.,2025,10.3390/jcm14082852,https://pubmed.ncbi.nlm.nih.gov/40283684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,39426221,Integrating GWAS and transcriptomics to identify candidate genes conferring relative growth rate trait in white-feathered broiler.,2024,10.1016/j.psj.2024.104338,https://pubmed.ncbi.nlm.nih.gov/39426221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,42280685,"Temperature-Dependent Clonal and Species-Level Growth Variation in &lt;i&gt;Spirodela&lt;/i&gt;, &lt;i&gt;Landoltia&lt;/i&gt;, &lt;i&gt;Lemna&lt;/i&gt;, and Interspecific &lt;i&gt;Lemna&lt;/i&gt; Hybrids.",2026,10.3390/plants15111649,https://pubmed.ncbi.nlm.nih.gov/42280685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,42103958,"Phytochemical-mediated variation in growth, feeding, and life table parameters of Phthorimaea operculella (Lepidoptera: Gelechiidae).",2026,10.1038/s41598-026-52636-y,https://pubmed.ncbi.nlm.nih.gov/42103958/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,41663928,Genome-wide association analysis to identify candidate genes for growth rate traits in Chinese endemic geese.,2026,10.1186/s12864-026-12518-z,https://pubmed.ncbi.nlm.nih.gov/41663928/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,41902378,"Deep Learning Can Predict the Overall Survival of Cervical Cancer Based on Histopathological Image, Gene Mutation and Clinical Information.",2026,10.1049/syb2.70060,https://pubmed.ncbi.nlm.nih.gov/41902378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,38299232,Expression Analysis of Retinal G Protein-coupled Receptor and its Correlation with Regulation of the Balance between Proliferation and Aberrant Differentiation in Cutaneous Squamous Cell Carcinoma.,2024,10.2340/actadv.v104.13213,https://pubmed.ncbi.nlm.nih.gov/38299232/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,42884907,Potential Toxicity of Microplastics in Wheat and Maize-A Pilot Pot Experiment.,2026,10.3390/plants15193043,https://pubmed.ncbi.nlm.nih.gov/42884907/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,41706326,Assessing the effects of high concentration of pure Cry proteins exposure on the Eisenia fetida by allying transcriptome analysis with toxicological evaluation.,2026,10.1007/s10646-026-03031-w,https://pubmed.ncbi.nlm.nih.gov/41706326/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,40945445,Heteroaggregation between polystyrene micro(nano)plastics and dibutyl phthalate mediates toxicity reduction in macroalgae: Physiological and transcriptomic evidence from Gracilariopsis lemaneiformis.,2025,10.1016/j.jhazmat.2025.139805,https://pubmed.ncbi.nlm.nih.gov/40945445/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,41465661,Insecticidal and Repellent Activity of Different Pomegranate Peel Extracts Against Granary Weevil Adults.,2025,10.3390/insects16121222,https://pubmed.ncbi.nlm.nih.gov/41465661/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,41489541,"The potentials of &lt;i&gt;Sporobolus pyramidalis&lt;/i&gt; and &lt;i&gt;Sacciolepis africana&lt;/i&gt; in phytoremediation of heavy metals from challawa contaminated soil, Kano, Nigeria.",2026,10.1080/15226514.2025.2611019,https://pubmed.ncbi.nlm.nih.gov/41489541/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,41715051,Cytotoxicity and bonding property of biomimetic ceramic fiber-resin composites.,2026,10.1186/s12903-026-07922-6,https://pubmed.ncbi.nlm.nih.gov/41715051/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,42162826,Ecotoxicity of single silver nanoparticles and combined silver nanoparticles and humic acid on Limnobium laevigatum.,2026,10.1016/j.envpol.2026.128388,https://pubmed.ncbi.nlm.nih.gov/42162826/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,41302892,"Assessing the Chronic Effects of Dietary Aluminum on Fitness Traits, Acetylcholinesterase Activity and Locomotion in &lt;i&gt;Lymantria dispar&lt;/i&gt; L. Larvae.",2025,10.3390/insects16111146,https://pubmed.ncbi.nlm.nih.gov/41302892/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,41138403,"Phytotest-based study on the concentration-dependent dynamic interactions of Cd, Pb, and As under multiple exposure conditions in purple soils.",2025,10.1016/j.jhazmat.2025.140158,https://pubmed.ncbi.nlm.nih.gov/41138403/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,40780306,"Parquetina nigrescens leaf extract mitigates aflatoxin B1-induced stress, immune and growth disruptions in broilers.",2025,10.1016/j.toxicon.2025.108523,https://pubmed.ncbi.nlm.nih.gov/40780306/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,39970496,Effects of sulfonamide on water remediation by aquatic plants: Insight from toxicological responses.,2025,10.1016/j.ecoenv.2025.117919,https://pubmed.ncbi.nlm.nih.gov/39970496/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,39349896,Tolerance and phytoremediation capacity of atrazine and S-metolachlor by two duckweeds.,2024,10.1007/s11356-024-35122-8,https://pubmed.ncbi.nlm.nih.gov/39349896/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,41302039,Effects of Macronutrients in Ten Different Plant Species on the Food Choice and Growth Performance of &lt;i&gt;Achatina fulica&lt;/i&gt;.,2025,10.3390/ani15223333,https://pubmed.ncbi.nlm.nih.gov/41302039/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,41741509,"Evaluation of commercial probiotics for growth, health, and biometric indices of Thai silver barb (Barbonymus gonionotus).",2026,10.1038/s41598-026-37975-0,https://pubmed.ncbi.nlm.nih.gov/41741509/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGR,ENSG00000148604,Unsafe,7947717,A human opsin-related gene that encodes a retinaldehyde-binding protein.,1994,10.1021/bi00248a022,https://pubmed.ncbi.nlm.nih.gov/7947717/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS22,ENSG00000132554,Unsafe,42342706,RGS22 is a metazoa-specific radial spoke component required for coordinated ciliary beating.,2026,10.1038/s41467-026-74801-7,https://pubmed.ncbi.nlm.nih.gov/42342706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS22,ENSG00000132554,Unsafe,39400871,RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus.,2025,10.1007/s11427-024-2720-8,https://pubmed.ncbi.nlm.nih.gov/39400871/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS22,ENSG00000132554,Unsafe,36380881,"Suppressive effect of YY1-mediated RGS22 regulation on the proliferation, migration and invasion of pancreatic ductal adenocarcinoma.",2022,10.3892/ol.2022.13577,https://pubmed.ncbi.nlm.nih.gov/36380881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS22,ENSG00000132554,Unsafe,38124114,"A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide.",2023,10.1186/s13148-023-01598-3,https://pubmed.ncbi.nlm.nih.gov/38124114/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS22,ENSG00000132554,Unsafe,29038925,miR-1260b promotes cell migration and invasion of hepatocellular carcinoma by targeting the regulator of G-protein signaling 22.,2018,10.1007/s10529-017-2455-6,https://pubmed.ncbi.nlm.nih.gov/29038925/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS22,ENSG00000132554,Unsafe,26323264,RGS22 inhibits pancreatic adenocarcinoma cell migration through the G12/13 α subunit/F-actin pathway.,2015,10.3892/or.2015.4209,https://pubmed.ncbi.nlm.nih.gov/26323264/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS22,ENSG00000132554,Unsafe,21533872,"RGS22, a novel cancer/testis antigen, inhibits epithelial cell invasion and metastasis.",2011,10.1007/s10585-011-9390-z,https://pubmed.ncbi.nlm.nih.gov/21533872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS22,ENSG00000132554,Unsafe,24403052,Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.,2014,10.1093/hmg/ddt671,https://pubmed.ncbi.nlm.nih.gov/24403052/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS22,ENSG00000132554,Unsafe,18703424,"RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits.",2008,10.1095/biolreprod.107.067504,https://pubmed.ncbi.nlm.nih.gov/18703424/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS22,ENSG00000132554,Unsafe,28219342,Effects of exposure to Streptococcus iniae on microRNA expression in the head kidney of genetically improved farmed tilapia (Oreochromis niloticus).,2017,10.1186/s12864-017-3591-z,https://pubmed.ncbi.nlm.nih.gov/28219342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS22,ENSG00000132554,Unsafe,26474971,"A genome-wide approach to link genotype to clinical outcome by utilizing next generation sequencing and gene chip data of 6,697 breast cancer patients.",2015,10.1186/s13073-015-0228-1,https://pubmed.ncbi.nlm.nih.gov/26474971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,42233024,"Multimodal integration of neuroimaging, transcriptomics and single-cell analysis reveals molecular correlates linking osteoporosis to brain abnormalities.",2026,10.3389/fimmu.2026.1817475,https://pubmed.ncbi.nlm.nih.gov/42233024/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,41169112,Molecular Mechanism of Dexmedetomidine in Alzheimer's Disease: Machine Learning Identifies RGS7 as a Key Therapeutic Targe.,2025,10.1111/cbdd.70185,https://pubmed.ncbi.nlm.nih.gov/41169112/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,40704638,Developmental regulation of GABA&lt;sub&gt;B&lt;/sub&gt; receptors and downstream molecules in the mouse brain.,2025,10.14670/hh-18-970,https://pubmed.ncbi.nlm.nih.gov/40704638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,40086518,Silencing RGS7 attenuates atrial fibrillation progression by activating the cGMP-PKG signaling pathway.,2025,10.1016/j.bbadis.2025.167786,https://pubmed.ncbi.nlm.nih.gov/40086518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,40337551,Osteocalcin and GPR158: linking bone and brain function.,2025,10.3389/fcell.2025.1564751,https://pubmed.ncbi.nlm.nih.gov/40337551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,39542413,Receptor-dependent influence of R7 RGS proteins on neuronal GIRK channel signaling dynamics.,2024,10.1016/j.pneurobio.2024.102686,https://pubmed.ncbi.nlm.nih.gov/39542413/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,40979532,Molecular pathogenesis of Alzheimer's disease onset in a mouse model: effects of cannabidiol treatment.,2025,10.3389/fnins.2025.1667585,https://pubmed.ncbi.nlm.nih.gov/40979532/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,37589751,RGS7 balances acetylation/de-acetylation of p65 to control chemotherapy-dependent cardiac inflammation.,2023,10.1007/s00018-023-04895-5,https://pubmed.ncbi.nlm.nih.gov/37589751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,36574707,A RGS7-CaMKII complex drives myocyte-intrinsic and myocyte-extrinsic mechanisms of chemotherapy-induced cardiotoxicity.,2023,10.1073/pnas.2213537120,https://pubmed.ncbi.nlm.nih.gov/36574707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,41935835,G protein regulatory network shapes magnitude and kinetics of behavioral responses in an engineered opioid receptor model.,2026,10.1016/j.jbc.2026.111425,https://pubmed.ncbi.nlm.nih.gov/41935835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,37219953,Specific regulation of mechanical nociception by Gβ5 involves GABA-B receptors.,2023,10.1172/jci.insight.134685,https://pubmed.ncbi.nlm.nih.gov/37219953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,36467406,The emerging roles of GPR158 in the regulation of the endocrine system.,2022,10.3389/fcell.2022.1034348,https://pubmed.ncbi.nlm.nih.gov/36467406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,37047347,Non-Ceruloplasmin Copper Identifies a Subtype of Alzheimer's Disease (CuAD): Characterization of the Cognitive Profile and Case of a CuAD Patient Carrying an RGS7 Stop-Loss Variant.,2023,10.3390/ijms24076377,https://pubmed.ncbi.nlm.nih.gov/37047347/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,36999276,RGS7 silence protects palmitic acid-induced pancreatic β-cell injury by inactivating the chemokine signaling pathway.,2023,10.1080/08916934.2023.2194584,https://pubmed.ncbi.nlm.nih.gov/36999276/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,40425987,Genetic markers of thrombophilia as predictors of outcome in colorectal cancer.,2025,10.1007/s11239-025-03106-1,https://pubmed.ncbi.nlm.nih.gov/40425987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,37440271,Cardiac RGS7 and RGS11 drive TGFβ1-dependent liver damage following chemotherapy exposure.,2023,10.1096/fj.202300094r,https://pubmed.ncbi.nlm.nih.gov/37440271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,36357076,"The interaction, mechanism and function of GPR158-RGS7 cross-talk.",2022,10.1016/bs.pmbts.2022.06.007,https://pubmed.ncbi.nlm.nih.gov/36357076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,40769724,Pre- and Post-synaptic Mechanisms of Neuronal Inhibition Assessed Through Biochemically Detailed Modeling of GABA&lt;sub&gt;B&lt;/sub&gt; Receptor Signaling.,2025,10.1523/jneurosci.0544-25.2025,https://pubmed.ncbi.nlm.nih.gov/40769724/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,33931669,Arginyltransferase (Ate1) regulates the RGS7 protein level and the sensitivity of light-evoked ON-bipolar responses.,2021,10.1038/s41598-021-88628-3,https://pubmed.ncbi.nlm.nih.gov/33931669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,35127722,Arginylation Regulates G-protein Signaling in the Retina.,2021,10.3389/fcell.2021.807345,https://pubmed.ncbi.nlm.nih.gov/35127722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,38444027,Genomic determinants of antibody response to a typhoid vaccine in Indian recipients.,2024,10.1007/s12041-024-01463-z,https://pubmed.ncbi.nlm.nih.gov/38444027/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,37761960,Identification of Breast Cancer Metastasis Markers from Gene Expression Profiles Using Machine Learning Approaches.,2023,10.3390/genes14091820,https://pubmed.ncbi.nlm.nih.gov/37761960/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,34112017,Identification of Potential Modulators of the RGS7/Gβ5/R7BP Complex.,2021,10.1177/24725552211020679,https://pubmed.ncbi.nlm.nih.gov/34112017/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,33402347,Striatal RGS7 Regulates Depression-Related Behaviors and Stress-Induced Reinstatement of Cocaine Conditioned Place Preference.,2021,10.1523/eneuro.0365-20.2020,https://pubmed.ncbi.nlm.nih.gov/33402347/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,31311860,The signaling proteins GPR158 and RGS7 modulate excitability of L2/3 pyramidal neurons and control A-type potassium channel in the prelimbic cortex.,2019,10.1074/jbc.ra119.007533,https://pubmed.ncbi.nlm.nih.gov/31311860/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,36362230,"Spatial Memory Training Counteracts Hippocampal GIRK Channel Decrease in the Transgenic APPSw,Ind J9 Alzheimer's Disease Mouse Model.",2022,10.3390/ijms232113444,https://pubmed.ncbi.nlm.nih.gov/36362230/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,29658790,A High-Throughput Time-Resolved Fluorescence Energy Transfer Assay to Screen for Modulators of RGS7/Gβ5/R7BP Complex.,2018,10.1089/adt.2017.839,https://pubmed.ncbi.nlm.nih.gov/29658790/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,24755289,RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling.,2014,10.7554/elife.02053,https://pubmed.ncbi.nlm.nih.gov/24755289/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,27578457,Chronic exposure to cannabinoids during adolescence causes long-lasting behavioral deficits in adult mice.,2017,10.1111/adb.12446,https://pubmed.ncbi.nlm.nih.gov/27578457/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,32350740,Integrative analysis of in vivo recording with single-cell RNA-seq data reveals molecular properties of light-sensitive neurons in mouse V1.,2020,10.1007/s13238-020-00720-y,https://pubmed.ncbi.nlm.nih.gov/32350740/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,20043004,R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaine.,2010,10.1038/npp.2009.212,https://pubmed.ncbi.nlm.nih.gov/20043004/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,26321241,The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration.,2015,10.1016/j.neuroscience.2015.08.053,https://pubmed.ncbi.nlm.nih.gov/26321241/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,28687610,Regulator of G-protein signaling Gβ5-R7 is a crucial activator of muscarinic M3 receptor-stimulated insulin secretion.,2017,10.1096/fj.201700197rr,https://pubmed.ncbi.nlm.nih.gov/28687610/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,26098217,Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer.,2015,10.1172/jci81380,https://pubmed.ncbi.nlm.nih.gov/26098217/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,28476931,A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in GPR158 Associated With Reduced Energy Expenditure in American Indians.,2017,10.2337/db16-1565,https://pubmed.ncbi.nlm.nih.gov/28476931/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS7,ENSG00000182901,Unsafe,23555580,Multiple hits for the association of uterine fibroids on human chromosome 1q43.,2013,10.1371/journal.pone.0058399,https://pubmed.ncbi.nlm.nih.gov/23555580/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,40355655,Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens.,2025,10.1038/s41401-025-01565-z,https://pubmed.ncbi.nlm.nih.gov/40355655/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,42290675,Loss of SARM1 Improves Phenotypes in a Mouse Model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay.,2026,10.1212/nxg.0000000000200400,https://pubmed.ncbi.nlm.nih.gov/42290675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,39207522,Anti-RGS8 paraneoplastic cerebellar ataxia is preferentially associated with a particular subtype of Hodgkin's lymphoma.,2024,10.1007/s00415-024-12618-4,https://pubmed.ncbi.nlm.nih.gov/39207522/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,41074411,Elevated Regulator of G Protein Signaling 8 (Rgs8) Expression in Cerebellar Purkinje Cells of a Non-Manifesting SCA14 Murine Line.,2025,10.31083/jin40839,https://pubmed.ncbi.nlm.nih.gov/41074411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,42710022,"Paraneoplastic neurological syndromes: an update on incidence, antibody discovery, and testing.",2026,10.1097/cco.0000000000001268,https://pubmed.ncbi.nlm.nih.gov/42710022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,38671425,Identification of SUMOylation-related biomarkers in papillary thyroid carcinoma.,2024,10.1186/s12935-024-03323-3,https://pubmed.ncbi.nlm.nih.gov/38671425/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,42218517,Integrative single-cell and bulk transcriptomics define cell death patterns and ZDHHC22 in gastric cancer progression.,2026,10.1186/s12920-026-02405-7,https://pubmed.ncbi.nlm.nih.gov/42218517/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,37550073,Utility of Protein Microarrays for Detection of Classified and Novel Antibodies in Autoimmune Neurologic Disease.,2023,10.1212/nxi.0000000000200145,https://pubmed.ncbi.nlm.nih.gov/37550073/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,35712654,CRISPR-Cas13-Mediated Knockdown of Regulator of G-Protein Signaling 8 (RGS8) Does Not Affect Purkinje Cell Dendritic Development.,2022,10.3389/fcell.2022.854273,https://pubmed.ncbi.nlm.nih.gov/35712654/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,36059514,Key molecules associated with thyroid carcinoma prognosis: A study based on transcriptome sequencing and GEO datasets.,2022,10.3389/fimmu.2022.964891,https://pubmed.ncbi.nlm.nih.gov/36059514/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,33782191,Autoantibodies Against the Purkinje Cell Protein RGS8 in Paraneoplastic Cerebellar Syndrome.,2021,10.1212/nxi.0000000000000987,https://pubmed.ncbi.nlm.nih.gov/33782191/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,33553137,Modulation of Increased mGluR1 Signaling by RGS8 Protects Purkinje Cells From Dendritic Reduction and Could Be a Common Mechanism in Diverse Forms of Spinocerebellar Ataxia.,2020,10.3389/fcell.2020.569889,https://pubmed.ncbi.nlm.nih.gov/33553137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,38936254,Redox-modulated SNX25 as a novel regulator of GPCR-G protein signaling from endosomes.,2024,10.1016/j.redox.2024.103253,https://pubmed.ncbi.nlm.nih.gov/38936254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,37186850,A self-inactivating invertebrate opsin optically drives biased signaling toward Gβγ-dependent ion channel modulation.,2023,10.1073/pnas.2301269120,https://pubmed.ncbi.nlm.nih.gov/37186850/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,38558529,Identification of a risk score model based on tertiary lymphoid structure-related genes for predicting immunotherapy efficacy in non-small cell lung cancer.,2024,10.1111/1759-7714.15299,https://pubmed.ncbi.nlm.nih.gov/38558529/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,31543506,"An Interhelical Salt Bridge Controls Flexibility and Inhibitor Potency for Regulators of G-protein Signaling Proteins 4, 8, and 19.",2019,10.1124/mol.119.117176,https://pubmed.ncbi.nlm.nih.gov/31543506/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,30038610,"A Spectrum of Neural Autoantigens, Newly Identified by Histo-Immunoprecipitation, Mass Spectrometry, and Recombinant Cell-Based Indirect Immunofluorescence.",2018,10.3389/fimmu.2018.01447,https://pubmed.ncbi.nlm.nih.gov/30038610/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,29758252,Depression-resistant Phenotype in Mice Overexpressing Regulator of G Protein Signaling 8 (RGS8).,2018,10.1016/j.neuroscience.2018.05.005,https://pubmed.ncbi.nlm.nih.gov/29758252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,25902068,Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model.,2015,10.1371/journal.pgen.1005182,https://pubmed.ncbi.nlm.nih.gov/25902068/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,28736108,Chronic intermittent ethanol exposure selectively alters the expression of Gα subunit isoforms and RGS subtypes in rat prefrontal cortex.,2017,10.1016/j.brainres.2017.07.014,https://pubmed.ncbi.nlm.nih.gov/28736108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,28405024,Antisense oligonucleotide therapy for spinocerebellar ataxia type 2.,2017,10.1038/nature22044,https://pubmed.ncbi.nlm.nih.gov/28405024/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,27012587,In silico prediction of microRNAs on fluoride induced sperm toxicity in mice.,2016,10.1016/j.fct.2016.03.005,https://pubmed.ncbi.nlm.nih.gov/27012587/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,20573995,RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling.,2010,10.1152/ajpcell.00441.2009,https://pubmed.ncbi.nlm.nih.gov/20573995/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,26321241,The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration.,2015,10.1016/j.neuroscience.2015.08.053,https://pubmed.ncbi.nlm.nih.gov/26321241/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,18262772,Association of RGS2 and RGS5 variants with schizophrenia symptom severity.,2008,10.1016/j.schres.2008.01.006,https://pubmed.ncbi.nlm.nih.gov/18262772/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RGS8,ENSG00000135824,Unsafe,23626793,A high throughput screen for RGS proteins using steady state monitoring of free phosphate formation.,2013,10.1371/journal.pone.0062247,https://pubmed.ncbi.nlm.nih.gov/23626793/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,41864117,RHOXF1/TSGA10 axis: a possible molecular mechanism of carcinogenesis.,2026,10.1016/j.ctarc.2026.101183,https://pubmed.ncbi.nlm.nih.gov/41864117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,37761825,Mammal Reproductive Homeobox (Rhox) Genes: An Update of Their Involvement in Reproduction and Development.,2023,10.3390/genes14091685,https://pubmed.ncbi.nlm.nih.gov/37761825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,38258527,Deleterious variants in X-linked RHOXF1 cause male infertility with oligo- and azoospermia.,2024,10.1093/molehr/gaae002,https://pubmed.ncbi.nlm.nih.gov/38258527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,36750933,EIF5A2 specifically regulates the transcription of aging-related genes in human neuroblastoma cells.,2023,10.1186/s12877-023-03793-6,https://pubmed.ncbi.nlm.nih.gov/36750933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,33511215,Potential Prognostic Biomarkers of Lung Adenocarcinoma Based on Bioinformatic Analysis.,2021,10.1155/2021/8859996,https://pubmed.ncbi.nlm.nih.gov/33511215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,34824921,Transcriptome profiling of lncRNA and co-expression network in the vaginal epithelial tissue of women with lubrication disorders.,2021,10.7717/peerj.12485,https://pubmed.ncbi.nlm.nih.gov/34824921/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,36419649,A Novel Glycolysis-Related Long Noncoding RNA Signature for Predicting Overall Survival in Gastric Cancer.,2022,10.3389/pore.2022.1610643,https://pubmed.ncbi.nlm.nih.gov/36419649/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,33333852,The PARP Inhibitor Olaparib Modulates the Transcriptional Regulatory Networks of Long Non-Coding RNAs during Vasculogenic Mimicry.,2020,10.3390/cells9122690,https://pubmed.ncbi.nlm.nih.gov/33333852/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,28171660,The human RHOX gene cluster: target genes and functional analysis of gene variants in infertile men.,2016,10.1093/hmg/ddw313,https://pubmed.ncbi.nlm.nih.gov/28171660/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,23482336,The RHOX homeobox gene cluster is selectively expressed in human oocytes and male germ cells.,2013,10.1093/humrep/det043,https://pubmed.ncbi.nlm.nih.gov/23482336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,24377578,"Expression analysis of two cancer-testis genes, FBXO39 and TDRD4, in breast cancer tissues and cell lines.",2014,10.7314/apjcp.2013.14.11.6625,https://pubmed.ncbi.nlm.nih.gov/24377578/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,34532463,Genomic instability-associated lncRNA signature predicts prognosis and distinct immune landscape in gastric cancer.,2021,10.21037/atm-21-3569,https://pubmed.ncbi.nlm.nih.gov/34532463/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,36553659,Identification of Genetic Effects of ACADVL and IRF6 Genes with Milk Production Traits of Holstein Cattle in China.,2022,10.3390/genes13122393,https://pubmed.ncbi.nlm.nih.gov/36553659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,23317270,shRNA mediated RHOXF1 silencing influences expression of BCL2 but not CASP8 in MCF-7 and MDA-MB-231 cell lines.,2012,10.7314/apjcp.2012.13.11.5865,https://pubmed.ncbi.nlm.nih.gov/23317270/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,30207747,A Novel Variant of Desmoplakin Is Potentially Associated with Silicosis Risk.,2018,10.1089/dna.2018.4370,https://pubmed.ncbi.nlm.nih.gov/30207747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,11980563,"OTEX, an androgen-regulated human member of the paired-like class of homeobox genes.",2002,10.1042/bj20020399,https://pubmed.ncbi.nlm.nih.gov/11980563/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,21609483,Homeobox gene Rhox5 is regulated by epigenetic mechanisms in cancer and stem cells and promotes cancer growth.,2011,10.1186/1476-4598-10-63,https://pubmed.ncbi.nlm.nih.gov/21609483/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,16263810,Hypercalcemia of malignancy due to ectopic transactivation of the parathyroid hormone gene.,2006,10.1210/jc.2005-2095,https://pubmed.ncbi.nlm.nih.gov/16263810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,18072571,[Analyses of differential expression of Homeobox genes between lingual squamaous cell carcinoma and normal mucosa].,2007,,https://pubmed.ncbi.nlm.nih.gov/18072571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,11001876,Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.,2000,10.1042/0264-6021:3510019,https://pubmed.ncbi.nlm.nih.gov/11001876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RHOXF1,ENSG00000101883,Unsafe,12490318,"Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis.",2002,10.1016/s0378-1119(02)01087-9,https://pubmed.ncbi.nlm.nih.gov/12490318/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIBC1,ENSG00000158423,Unsafe,42525292,Blood-based RBBP7 and RIBC1 methylation as a candidate epigenetic biomarker for ovarian cancer epigenetic markers RBBP7 and RIBC1 in ovarian cancer.,2026,10.1007/s11033-026-12485-4,https://pubmed.ncbi.nlm.nih.gov/42525292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIBC1,ENSG00000158423,Unsafe,40265983,The absence of both RIBC1 and RIBC2 induces decreased sperm motility and litter size in male mice.,2026,10.1111/andr.70045,https://pubmed.ncbi.nlm.nih.gov/40265983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIBC1,ENSG00000158423,Unsafe,42563519,Systematic Reanalysis of Whole-Exome Sequencing in Genetically Unsolved Pediatric Primary Ciliary Dyskinesia.,2026,10.1002/ppul.71776,https://pubmed.ncbi.nlm.nih.gov/42563519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIBC1,ENSG00000158423,Unsafe,29982135,Identification of biomarker candidates for fertility in spermatozoa of crossbred bulls through comparative proteomics.,2018,10.1016/j.theriogenology.2018.06.021,https://pubmed.ncbi.nlm.nih.gov/29982135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIBC1,ENSG00000158423,Unsafe,18252223,Submicroscopic duplications of the hydroxysteroid dehydrogenase HSD17B10 and the E3 ubiquitin ligase HUWE1 are associated with mental retardation.,2008,10.1016/j.ajhg.2007.11.002,https://pubmed.ncbi.nlm.nih.gov/18252223/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIBC2,ENSG00000128408,Unsafe,41666178,Integrative bioinformatics and experiments identify RIBC2 as a key regulator in the esophageal cancer.,2026,10.1371/journal.pone.0340850,https://pubmed.ncbi.nlm.nih.gov/41666178/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIBC2,ENSG00000128408,Unsafe,40265983,The absence of both RIBC1 and RIBC2 induces decreased sperm motility and litter size in male mice.,2026,10.1111/andr.70045,https://pubmed.ncbi.nlm.nih.gov/40265983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIBC2,ENSG00000128408,Unsafe,39963268,Potential biomarkers and immune infiltration linking endometriosis with recurrent pregnancy loss based on bioinformatics and machine learning.,2025,10.3389/fmolb.2025.1529507,https://pubmed.ncbi.nlm.nih.gov/39963268/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIBC2,ENSG00000128408,Unsafe,36508087,Ckb and Ybx2 interact with Ribc2 and are necessary for the ciliary beating of multi-cilia.,2023,10.1007/s13258-022-01350-w,https://pubmed.ncbi.nlm.nih.gov/36508087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIBC2,ENSG00000128408,Unsafe,37394087,Epigenome-wide association study identifies Vogt-Koyanagi-Harada disease-associated DNA methylation loci in Chinese.,2023,10.1016/j.exer.2023.109553,https://pubmed.ncbi.nlm.nih.gov/37394087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIBC2,ENSG00000128408,Unsafe,32616903,The transcriptional signature associated with human motile cilia.,2020,10.1038/s41598-020-66453-4,https://pubmed.ncbi.nlm.nih.gov/32616903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIBC2,ENSG00000128408,Unsafe,34530829,Determination of a six-gene prognostic model for cervical cancer based on WGCNA combined with LASSO and Cox-PH analysis.,2021,10.1186/s12957-021-02384-2,https://pubmed.ncbi.nlm.nih.gov/34530829/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIBC2,ENSG00000128408,Unsafe,32329860,A common variant rs2272804 in the 5'UTR of RIBC2 inhibits downstream gene expression by creating an upstream open reading frame.,2020,10.26355/eurrev_202004_20851,https://pubmed.ncbi.nlm.nih.gov/32329860/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIBC2,ENSG00000128408,Unsafe,36714595,"Overweight/obesity-related transcriptomic signature as a correlate of clinical outcome, immune microenvironment, and treatment response in hepatocellular carcinoma.",2022,10.3389/fendo.2022.1061091,https://pubmed.ncbi.nlm.nih.gov/36714595/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIBC2,ENSG00000128408,Unsafe,34674573,Identifying a cervical cancer survival signature based on mRNA expression and genome-wide copy number variations.,2022,10.1177/15353702211053580,https://pubmed.ncbi.nlm.nih.gov/34674573/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIBC2,ENSG00000128408,Unsafe,32202912,Identification of Key Genes in Association with Progression and Prognosis in Cervical Squamous Cell Carcinoma.,2020,10.1089/dna.2019.5202,https://pubmed.ncbi.nlm.nih.gov/32202912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIBC2,ENSG00000128408,Unsafe,27517910,A Genome-Wide Methylation Approach Identifies a New Hypermethylated Gene Panel in Ulcerative Colitis.,2016,10.3390/ijms17081291,https://pubmed.ncbi.nlm.nih.gov/27517910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIBC2,ENSG00000128408,Unsafe,36191189,SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.,2022,10.1073/pnas.2207605119,https://pubmed.ncbi.nlm.nih.gov/36191189/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,42500542,Case Report: Recurrent intrahepatic cholestasis: two rare cases with their novel variants of ATB8B1 and atypical clinical findings.,2026,10.3389/fmed.2026.1886444,https://pubmed.ncbi.nlm.nih.gov/42500542/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,42410101,Enhanced angiogenetic and proliferative effects of remote ischemic conditioning following esophageal resection and anastomosis in a rat model.,2026,10.1038/s41598-026-61062-z,https://pubmed.ncbi.nlm.nih.gov/42410101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,39632878,Structural basis for Rab6 activation by the Ric1-Rgp1 complex.,2024,10.1038/s41467-024-54869-9,https://pubmed.ncbi.nlm.nih.gov/39632878/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,41137173,Whole-genome sequencing reveals individual and cohort level insights into chromosome 9p syndromes.,2025,10.1186/s13073-025-01563-0,https://pubmed.ncbi.nlm.nih.gov/41137173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,37718531,Smooth Elongation of Pavement Cells Induced by RIC1 Overexpression Leads to Marginal Protrusions of the Cotyledon in Arabidopsis thaliana.,2023,10.1093/pcp/pcad094,https://pubmed.ncbi.nlm.nih.gov/37718531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,39657680,Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening.,2024,10.1016/j.cels.2024.11.004,https://pubmed.ncbi.nlm.nih.gov/39657680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,36493769,"Genome-wide analysis of copy-number variation in humans with cleft lip and/or cleft palate identifies COBLL1, RIC1, and ARHGEF38 as clefting genes.",2023,10.1016/j.ajhg.2022.11.012,https://pubmed.ncbi.nlm.nih.gov/36493769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,31932796,"Phenome-based approach identifies RIC1-linked Mendelian syndrome through zebrafish models, biobank associations and clinical studies.",2020,10.1038/s41591-019-0705-y,https://pubmed.ncbi.nlm.nih.gov/31932796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,27878435,Novel phenotypes and loci identified through clinical genomics approaches to pediatric cataract.,2017,10.1007/s00439-016-1747-6,https://pubmed.ncbi.nlm.nih.gov/27878435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,28070891,A ROP2-RIC1 pathway fine-tunes microtubule reorganization for salt tolerance in Arabidopsis.,2017,10.1111/pce.12905,https://pubmed.ncbi.nlm.nih.gov/28070891/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,25804540,Arabidopsis RIC1 Severs Actin Filaments at the Apex to Regulate Pollen Tube Growth.,2015,10.1105/tpc.114.135400,https://pubmed.ncbi.nlm.nih.gov/25804540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,27124376,Trichomonas vaginalis Repair of Iron Centres Proteins: The Different Role of Two Paralogs.,2016,10.1016/j.protis.2016.03.001,https://pubmed.ncbi.nlm.nih.gov/27124376/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,23091056,Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase.,2012,10.1074/jbc.m112.414565,https://pubmed.ncbi.nlm.nih.gov/23091056/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,23716474,Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer.,2013,10.1002/gcc.22076,https://pubmed.ncbi.nlm.nih.gov/23716474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,23078108,Arabidopsis ROP-interactive CRIB motif-containing protein 1 (RIC1) positively regulates auxin signalling and negatively regulates abscisic acid (ABA) signalling during root development.,2013,10.1111/pce.12028,https://pubmed.ncbi.nlm.nih.gov/23078108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,29752856,Ethylene-induced microtubule reorientation is essential for fast inhibition of root elongation in Arabidopsis.,2018,10.1111/jipb.12666,https://pubmed.ncbi.nlm.nih.gov/29752856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,20623139,"Isolation of a fission yeast mutant that is sensitive to valproic acid and defective in the gene encoding Ric1, a putative component of Ypt/Rab-specific GEF for Ryh1 GTPase.",2010,10.1007/s00438-010-0550-7,https://pubmed.ncbi.nlm.nih.gov/20623139/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,28355295,Risk prediction of pulmonary tuberculosis using genetic and conventional risk factors in adult Korean population.,2017,10.1371/journal.pone.0174642,https://pubmed.ncbi.nlm.nih.gov/28355295/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,22683261,ABP1 and ROP6 GTPase signaling regulate clathrin-mediated endocytosis in Arabidopsis roots.,2012,10.1016/j.cub.2012.05.020,https://pubmed.ncbi.nlm.nih.gov/22683261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,25788735,Dissecting the contribution of microtubule behaviour in adventitious root induction.,2015,10.1093/jxb/erv097,https://pubmed.ncbi.nlm.nih.gov/25788735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,37658626,A novel SLC1A1-RIC1 fusion sensitive to asparaginase-based therapy in natural killer/T-cell lymphoma.,2023,10.1111/bjh.19066,https://pubmed.ncbi.nlm.nih.gov/37658626/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,34288396,GTPase ROP6 negatively modulates phosphate deficiency through inhibition of PHT1;1 and PHT1;4 in Arabidopsis thaliana.,2021,10.1111/jipb.13153,https://pubmed.ncbi.nlm.nih.gov/34288396/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,26437057,Second reduced intensity conditioning allogeneic transplant as a rescue strategy for acute leukaemia patients who relapse after an initial RIC allogeneic transplantation: analysis of risk factors and treatment outcomes.,2016,10.1038/bmt.2015.221,https://pubmed.ncbi.nlm.nih.gov/26437057/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,22403011,Delineation of the molecular mechanism for disulfide stress-induced aluminium toxicity.,2012,10.1007/s10534-012-9534-x,https://pubmed.ncbi.nlm.nih.gov/22403011/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,16112082,Molecular cloning and functional analysis of a novel Cx43 partner protein CIP150.,2005,10.1016/j.bbrc.2005.08.019,https://pubmed.ncbi.nlm.nih.gov/16112082/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIC1,ENSG00000107036,Unsafe,10718198,Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.,2000,10.1093/dnares/7.1.65,https://pubmed.ncbi.nlm.nih.gov/10718198/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIIAD1,ENSG00000178796,Unsafe,42010243,A high-resolution spatial map of cilia-associated proteins in the human fallopian tube.,2026,10.1038/s41467-026-71692-6,https://pubmed.ncbi.nlm.nih.gov/42010243/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIIAD1,ENSG00000178796,Unsafe,32412047,Integrative analysis of DNA methylation and gene expression profiles identified potential breast cancer-specific diagnostic markers.,2020,10.1042/bsr20201053,https://pubmed.ncbi.nlm.nih.gov/32412047/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIIAD1,ENSG00000178796,Unsafe,36334189,Identification of hub genes in AR-induced tamoxifen resistance in breast cancer based on weighted gene co-expression network analysis.,2023,10.1007/s10549-022-06788-w,https://pubmed.ncbi.nlm.nih.gov/36334189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,41345547,Mapping the brain cell-specific regulatory architecture of migraine: a single-cell causal framework nominating inhibitory-neuronal BTBD16 and astrocytic RIMS1 as therapeutic targets.,2025,10.1186/s10194-025-02241-7,https://pubmed.ncbi.nlm.nih.gov/41345547/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,40307326,Prognostic biomarker RIMS1 and its association with immune infiltration in glioblastoma.,2025,10.1038/s41598-025-99499-3,https://pubmed.ncbi.nlm.nih.gov/40307326/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,42336922,Dissecting the propensity of RIM1 subdomains to form phase condensates.,2026,10.1038/s41598-026-56567-6,https://pubmed.ncbi.nlm.nih.gov/42336922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,42660892,Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons.,2026,10.1038/s41467-026-75194-3,https://pubmed.ncbi.nlm.nih.gov/42660892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,41291187,Sh3rf3 Deficiency drives autism-like behaviors via presynaptic dysfunction in mice.,2026,10.1038/s41380-025-03370-w,https://pubmed.ncbi.nlm.nih.gov/41291187/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,41677698,Screening Candidate Genes for Body Size Traits in Dongfeng Sika Deer Bucks Based on Genome-Wide Association Analysis.,2026,10.3390/biology15030227,https://pubmed.ncbi.nlm.nih.gov/41677698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,40493522,The liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid-liquid phase separation.,2025,10.1371/journal.pbio.3002817,https://pubmed.ncbi.nlm.nih.gov/40493522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,41945433,Munc13 serves as a molecular filter for SNARE sorting and assembly in active zone condensates.,2026,10.1073/pnas.2529572123,https://pubmed.ncbi.nlm.nih.gov/41945433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,42412056,Evolution of CTCF binding sites in the human genome.,2026,10.1093/molbev/msag167,https://pubmed.ncbi.nlm.nih.gov/42412056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,42805121,A seven-gene signature associated with inner mitochondrial membrane protein-defined molecular subtypes for prognostic stratification in gastric cancer.,2026,10.1016/j.prp.2026.156699,https://pubmed.ncbi.nlm.nih.gov/42805121/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,38478593,Paroxysmal dystonia results from the loss of RIM4 in Purkinje cells.,2024,10.1093/brain/awae081,https://pubmed.ncbi.nlm.nih.gov/38478593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,42594474,Single-nucleus transcriptomics reveals cell-type-resolved brain responses to concurrent exposure to polyethylene nanoplastics and butyl benzyl phthalate.,2026,10.1016/j.jhazmat.2026.143284,https://pubmed.ncbi.nlm.nih.gov/42594474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,42571211,Integrative Analysis of Steroid Metabolism-Based Molecular Subtypes Reveals Prognostic Subtypes and Therapeutic Implications in Gastric Cancer.,2026,10.1177/11769351261475376,https://pubmed.ncbi.nlm.nih.gov/42571211/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,41492970,An R83W mutation in Rab3A causes autosomal-dominant cerebellar ataxia.,2026,10.1093/hmg/ddaf186,https://pubmed.ncbi.nlm.nih.gov/41492970/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,39567526,Genetic variants associated with longevity in long-living Indians.,2024,10.1038/s41514-024-00179-9,https://pubmed.ncbi.nlm.nih.gov/39567526/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,41351843,Protocol for single-molecule analysis of synaptic protein complex-mediated vesicle recruitment.,2025,10.1016/j.xpro.2025.104249,https://pubmed.ncbi.nlm.nih.gov/41351843/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,39814011,Intracellular protein-lipid interactions drive presynaptic assembly prior to neurexin recruitment.,2025,10.1016/j.neuron.2024.12.017,https://pubmed.ncbi.nlm.nih.gov/39814011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,40795403,Multiple autism genes influence GABA neuron remodeling via distinct developmental trajectories.,2025,10.1093/genetics/iyaf156,https://pubmed.ncbi.nlm.nih.gov/40795403/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,40240063,Precision risk stratification of primary gastric cancer after eradication of &lt;i&gt;H. pylori&lt;/i&gt; by a DNA methylation marker: a multicentre prospective study.,2025,10.1136/gutjnl-2025-335039,https://pubmed.ncbi.nlm.nih.gov/40240063/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,42405393,DYRK1A Signaling in the Brain: Molecular Mechanisms and Neurotransmitter Regulation.,2026,10.2174/0115672026453723260618053839,https://pubmed.ncbi.nlm.nih.gov/42405393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,41000562,Pharmacogenomics of the Etonogestrel Contraceptive Implant: A Genome-Wide Association Study of Steady-State Etonogestrel Concentrations.,2025,10.1097/og9.0000000000000066,https://pubmed.ncbi.nlm.nih.gov/41000562/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,37434820,Exploration and validation of m7G-related genes as signatures in the immune microenvironment and prognostic indicators in low-grade glioma.,2023,,https://pubmed.ncbi.nlm.nih.gov/37434820/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,40290521,A GWAS of angiotensin-converting enzyme inhibitor-induced angioedema in a South African population.,2025,10.1016/j.jacig.2025.100464,https://pubmed.ncbi.nlm.nih.gov/40290521/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,35794675,Establishment of a male fertility prediction model with sperm RNA markers in pigs as a translational animal model.,2022,10.1186/s40104-022-00729-9,https://pubmed.ncbi.nlm.nih.gov/35794675/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,38218585,Gene knockout of RNA binding motif 5 in the brain alters RIMS2 protein homeostasis in the cerebellum and Hippocampus and exacerbates behavioral deficits after a TBI in mice.,2024,10.1016/j.expneurol.2024.114690,https://pubmed.ncbi.nlm.nih.gov/38218585/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,30559150,Active Zone Proteins RIM1αβ Are Required for Normal Corticostriatal Transmission and Action Control.,2019,10.1523/jneurosci.1940-18.2018,https://pubmed.ncbi.nlm.nih.gov/30559150/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,35899365,"Whole-transcriptome sequencing identifies neuroinflammation, metabolism and blood-brain barrier related processes in the hippocampus of aged mice during perioperative period.",2022,10.1111/cns.13901,https://pubmed.ncbi.nlm.nih.gov/35899365/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,34357055,Proteomic Analysis Unveils Expressional Changes in Cytoskeleton- and Synaptic Plasticity-Associated Proteins in Rat Brain Six Months after Withdrawal from Morphine.,2021,10.3390/life11070683,https://pubmed.ncbi.nlm.nih.gov/34357055/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,22103334,Region-specific deletions of RIM1 reproduce a subset of global RIM1α(-/-)  phenotypes.,2012,10.1111/j.1601-183x.2011.00755.x,https://pubmed.ncbi.nlm.nih.gov/22103334/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,26741287,Genome-wide association study of antibody responses to Plasmodium falciparum candidate vaccine antigens.,2016,10.1038/gene.2015.59,https://pubmed.ncbi.nlm.nih.gov/26741287/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,30559594,Interplay Between Amphetamine and Activity Level in Gene Networks of the Mouse Striatum.,2018,10.1177/1177932218815152,https://pubmed.ncbi.nlm.nih.gov/30559594/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,17237123,Genetic enhancement of cognition in a kindred with cone-rod dystrophy due to RIMS1 mutation.,2007,10.1136/jmg.2006.047407,https://pubmed.ncbi.nlm.nih.gov/17237123/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RIMS1,ENSG00000079841,Unsafe,23999003,"SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation.",2013,10.1016/j.jdermsci.2013.07.010,https://pubmed.ncbi.nlm.nih.gov/23999003/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNASE8,ENSG00000173431,Unsafe,33057072,"Regulation of gene expression by miRNA-455-3p, upregulated in the conjunctival epithelium of patients with Stevens-Johnson syndrome in the chronic stage.",2020,10.1038/s41598-020-74211-9,https://pubmed.ncbi.nlm.nih.gov/33057072/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,39543487,Machine learning-driven discovery of novel therapeutic targets in diabetic foot ulcers.,2024,10.1186/s10020-024-00955-z,https://pubmed.ncbi.nlm.nih.gov/39543487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,42803658,Characterization of the Mos10 (Vps60) ESCRT-III complex.,2026,10.1042/bsr20260272,https://pubmed.ncbi.nlm.nih.gov/42803658/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,41129588,Estimating the effect on obesity of delaying tax-based interventions in Mexico: A modeling study.,2025,10.1371/journal.pmed.1004769,https://pubmed.ncbi.nlm.nih.gov/41129588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,39703749,The Alteration of Proteomic Profiles in Hippocampus of Type 2 Diabetic Mice Associated With Cognitive Impairment.,2024,10.1177/11779322241306290,https://pubmed.ncbi.nlm.nih.gov/39703749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,39937675,Orchestration of SARS-CoV-2 Nsp4 and host cell ESCRT proteins induces morphological changes of the endoplasmic reticulum.,2025,10.1091/mbc.e24-12-0542,https://pubmed.ncbi.nlm.nih.gov/39937675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,36035168,"The epiphany derived from T-cell-inflamed profiles: Pan-cancer characterization of CD8A as a biomarker spanning clinical relevance, cancer prognosis, immunosuppressive environment, and treatment responses.",2022,10.3389/fgene.2022.974416,https://pubmed.ncbi.nlm.nih.gov/36035168/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,39953471,Expected benefits of increasing taxes to nonessential energy-dense foods in Mexico: a modeling study.,2025,10.1186/s12889-025-21745-0,https://pubmed.ncbi.nlm.nih.gov/39953471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,39624861,Study of psychosocial factors and endothelial dysfunction in coronary heart disease patients.,2025,10.1080/00015385.2024.2436810,https://pubmed.ncbi.nlm.nih.gov/39624861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,37383428,The NED foundation experience: A model of global neurosurgery.,2023,10.1016/j.bas.2023.101741,https://pubmed.ncbi.nlm.nih.gov/37383428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,33956855,"Genetic analysis of the Drosophila ESCRT-III complex protein, VPS24, reveals a novel function in lysosome homeostasis.",2021,10.1371/journal.pone.0251184,https://pubmed.ncbi.nlm.nih.gov/33956855/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,38289107,Multifaceted interactions between host ESCRT-III and budded virus-related proteins involved in entry and egress of the baculovirus Autographa californica multiple nucleopolyhedrovirus.,2024,10.1128/jvi.01900-23,https://pubmed.ncbi.nlm.nih.gov/38289107/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,33634061,Potential Impact of the Nonessential Energy-Dense Foods Tax on the Prevalence of Overweight and Obesity in Children: A Modeling Study.,2020,10.3389/fpubh.2020.591696,https://pubmed.ncbi.nlm.nih.gov/33634061/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,34028356,Design principles of the ESCRT-III Vps24-Vps2 module.,2021,10.7554/elife.67709,https://pubmed.ncbi.nlm.nih.gov/34028356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,32875105,Structure and assembly of ESCRT-III helical Vps24 filaments.,2020,10.1126/sciadv.aba4897,https://pubmed.ncbi.nlm.nih.gov/32875105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,37768378,Vps60 initiates alternative ESCRT-III filaments.,2023,10.1083/jcb.202206028,https://pubmed.ncbi.nlm.nih.gov/37768378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,33747053,Multi-Omics Data Fusion via a Joint Kernel Learning Model for Cancer Subtype Discovery and Essential Gene Identification.,2021,10.3389/fgene.2021.647141,https://pubmed.ncbi.nlm.nih.gov/33747053/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,36814923,Genetic architecture of innate and adaptive immune cells in pigs.,2023,10.3389/fimmu.2023.1058346,https://pubmed.ncbi.nlm.nih.gov/36814923/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,31246173,Electrostatic lateral interactions drive ESCRT-III heteropolymer assembly.,2019,10.7554/elife.46207,https://pubmed.ncbi.nlm.nih.gov/31246173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,31997690,Abnormal Umblical Artery Doppler is Utilized for Fetuses with Intrauterine Growth Restriction Birth at 280/7-336/7 Gestational Weeks.,2020,10.1080/15513815.2020.1716900,https://pubmed.ncbi.nlm.nih.gov/31997690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,32184262,The ubiquitin hydrolase Doa4 directly binds Snf7 to inhibit recruitment of ESCRT-III remodeling factors in &lt;i&gt;S. cerevisiae&lt;/i&gt;.,2020,10.1242/jcs.241455,https://pubmed.ncbi.nlm.nih.gov/32184262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,29422608,Accelerated invagination of vacuoles as a stress response in chronically heat-stressed yeasts.,2018,10.1038/s41598-018-20781-8,https://pubmed.ncbi.nlm.nih.gov/29422608/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,22135362,"Rescue of Aspergillus nidulans severely debilitating null mutations in ESCRT-0, I, II and III genes by inactivation of a salt-tolerance pathway allows examination of ESCRT gene roles in pH signalling.",2011,10.1242/jcs.088344,https://pubmed.ncbi.nlm.nih.gov/22135362/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,21931550,Old world arenaviruses enter the host cell via the multivesicular body and depend on the endosomal sorting complex required for transport.,2011,10.1371/journal.ppat.1002232,https://pubmed.ncbi.nlm.nih.gov/21931550/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,22344261,An ordered pathway for the assembly of fungal ESCRT-containing ambient pH signalling complexes at the plasma membrane.,2012,10.1242/jcs.098897,https://pubmed.ncbi.nlm.nih.gov/22344261/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF103-CHMP3,ENSG00000249884,Unsafe,15632132,"Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1.",2005,10.1074/jbc.m413968200,https://pubmed.ncbi.nlm.nih.gov/15632132/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,42267516,RNF138-Mediated Ubiquitination and Degradation of NS5 Restricts Tick-Borne Encephalitis Virus Infection.,2026,10.1002/advs.75991,https://pubmed.ncbi.nlm.nih.gov/42267516/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,42365901,RNF138 polyubiquitinates glioma-associated oncogene 1 on K815/K942 to suppress Sonic Hedgehog signaling in medulloblastoma.,2026,10.1016/j.bcp.2026.118203,https://pubmed.ncbi.nlm.nih.gov/42365901/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,41088213,The enigma of the RING-UIM E3 ligases: its transformative impact on cancer research.,2025,10.1186/s12967-025-07194-8,https://pubmed.ncbi.nlm.nih.gov/41088213/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,42275215,RNF138 promotes cisplatin resistance and PD-L1-mediated immune evasion via JAK2/STAT3 activation in nasopharyngeal carcinoma.,2026,10.1016/j.celrep.2026.117547,https://pubmed.ncbi.nlm.nih.gov/42275215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,41655866,Matrix stiffness-induced NARF promotes hepatocellular carcinoma progression by enhancing LEF1-mediated transcription.,2026,10.1016/j.bbamcr.2026.120122,https://pubmed.ncbi.nlm.nih.gov/41655866/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,40225576,RNF138 regulates skeletal muscle differentiation via the Wnt/β-catenin signaling pathway.,2025,10.7150/thno.110925,https://pubmed.ncbi.nlm.nih.gov/40225576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,39609819,Pin1 promotes human Ca&lt;sub&gt;V&lt;/sub&gt;2.1 channel polyubiquitination by RNF138: pathophysiological implication for episodic ataxia type 2.,2024,10.1186/s12964-024-01960-9,https://pubmed.ncbi.nlm.nih.gov/39609819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,39789198,RNF138 contributes to cisplatin resistance in nasopharyngeal carcinoma cells.,2025,10.1038/s41598-025-85716-6,https://pubmed.ncbi.nlm.nih.gov/39789198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,41926452,Specificity and recognition of the ADP-ribosyl-ubiquitin modification in the DNA damage response.,2026,10.1371/journal.pbio.3003747,https://pubmed.ncbi.nlm.nih.gov/41926452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,38156932,E3 ubiquitin-ligase RNF138 may regulate p53 protein expression to regulate the self-renewal and tumorigenicity of glioma stem cells.,2023,10.4103/jcrt.jcrt_733_23,https://pubmed.ncbi.nlm.nih.gov/38156932/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,42112146,Aimed at Subtype Discrimination but Yielding a Shared Marker: Integrative Analysis of Blood Transcriptomes Reveals Upregulated &lt;i&gt;TLR5&lt;/i&gt; as a Potential Biomarker for IBD.,2026,10.2147/ceg.s584999,https://pubmed.ncbi.nlm.nih.gov/42112146/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,38666590,Ring finger protein 138 inhibits transcription factor C/EBPα protein turnover leading to differentiation arrest in acute myeloid leukemia.,2024,10.1042/bcj20240027,https://pubmed.ncbi.nlm.nih.gov/38666590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,42511805,MicroRNAs and Cellular Senescence in Melanoma: An Underexplored Link to Tumor Progression-A Systematic Review with Bioinformatics Analyses.,2026,10.3390/ijms27146462,https://pubmed.ncbi.nlm.nih.gov/42511805/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,40913148,Phase separation of ERCC6L2-CtIP regulates the extent of DNA end resection.,2025,10.1038/s41556-025-01760-4,https://pubmed.ncbi.nlm.nih.gov/40913148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,41082101,"A novel, cheap and easy preparing selective medium for isolation of Pythium species.",2025,10.1186/s13568-025-01946-x,https://pubmed.ncbi.nlm.nih.gov/41082101/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,38327035,"RING finger E3 ligase, RNF138 inhibits osteoblast differentiation by negatively regulating Runx2 protein turnover.",2024,10.1002/jcp.31217,https://pubmed.ncbi.nlm.nih.gov/38327035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,37768037,Mechanisms of Breast Cancer Stem Cell Specification and Self-Renewal Mediated by Hypoxia-Inducible Factor 1.,2023,10.1093/stcltm/szad061,https://pubmed.ncbi.nlm.nih.gov/37768037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,36490339,NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification.,2022,10.1126/sciadv.abo5000,https://pubmed.ncbi.nlm.nih.gov/36490339/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,35697692,RING finger 138 deregulation distorts NF-кB signaling and facilities colitis switch to aggressive malignancy.,2022,10.1038/s41392-022-00985-1,https://pubmed.ncbi.nlm.nih.gov/35697692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,39297544,Identification of susceptibility modules and characteristic genes to osteoarthritis by WGCNA.,2024,10.1684/abc.2024.1913,https://pubmed.ncbi.nlm.nih.gov/39297544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,40312849,Comparative efficacy of non-ablative radiofrequency and promestriene in management of the genitourinary syndrome and sexual dysfunction in cervical cancer survivors: a pilot randomized trial.,2025,10.1093/jsxmed/qdaf083,https://pubmed.ncbi.nlm.nih.gov/40312849/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,36800290,RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.,2023,10.1016/j.celrep.2023.112097,https://pubmed.ncbi.nlm.nih.gov/36800290/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,38737696,An innovative prognostic auxiliary for colon adenocarcinoma based on zinc finger protein genes.,2024,10.21037/tcr-23-2158,https://pubmed.ncbi.nlm.nih.gov/38737696/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,34759016,African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1.,2021,10.4049/jimmunol.2100320,https://pubmed.ncbi.nlm.nih.gov/34759016/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,33025009,MYD88 L265P elicits mutation-specific ubiquitination to drive NF-κB activation and lymphomagenesis.,2021,10.1182/blood.2020004918,https://pubmed.ncbi.nlm.nih.gov/33025009/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,37671148,Classification of subtypes and identification of dysregulated genes in sepsis.,2023,10.3389/fcimb.2023.1226159,https://pubmed.ncbi.nlm.nih.gov/37671148/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,33922038,Identification of 15 lncRNAs Signature for Predicting Survival Benefit of Advanced Melanoma Patients Treated with Anti-PD-1 Monotherapy.,2021,10.3390/cells10050977,https://pubmed.ncbi.nlm.nih.gov/33922038/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,27161866,RNF138 interacts with RAD51D and is required for DNA interstrand crosslink repair and maintaining chromosome integrity.,2016,10.1016/j.dnarep.2016.04.006,https://pubmed.ncbi.nlm.nih.gov/27161866/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,28167673,Ubiquitin Ligase RNF138 Promotes Episodic Ataxia Type 2-Associated Aberrant Degradation of Human Cav2.1 (P/Q-Type) Calcium Channels.,2017,10.1523/jneurosci.3070-16.2017,https://pubmed.ncbi.nlm.nih.gov/28167673/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,16714285,"NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF).",2006,10.1074/jbc.m602089200,https://pubmed.ncbi.nlm.nih.gov/16714285/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,23674306,Proteome-wide discovery of mislocated proteins in cancer.,2013,10.1101/gr.155499.113,https://pubmed.ncbi.nlm.nih.gov/23674306/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,19603079,Influence of smoking on colonic gene expression profile in Crohn's disease.,2009,10.1371/journal.pone.0006210,https://pubmed.ncbi.nlm.nih.gov/19603079/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,20373404,Gene expression profiling reveals early cellular responses to intracellular magnetic labeling with superparamagnetic iron oxide nanoparticles.,2010,10.1002/mrm.22290,https://pubmed.ncbi.nlm.nih.gov/20373404/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF138,ENSG00000134758,Unsafe,24394665,"Bortezomib inhibits STAT5-dependent degradation of LEF-1, inducing granulocytic differentiation in congenital neutropenia CD34(+) cells.",2014,10.1182/blood-2012-09-456889,https://pubmed.ncbi.nlm.nih.gov/24394665/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,41657776,Multi-omics characterization of RNF157 expression patterns in hepatocellular carcinoma and development of an RNF157-associated prognostic signature.,2025,10.3389/fphar.2025.1738424,https://pubmed.ncbi.nlm.nih.gov/41657776/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,40312343,RNF157 targets RIG-I/DDX58 to promote proliferation in liver cancer.,2025,10.1186/s12885-025-14224-7,https://pubmed.ncbi.nlm.nih.gov/40312343/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,42220229,Real-world-data for phenotypes and genotypes of rare monogenic genetic epilepsies and genes of uncertain significance for epilepsy.,2026,10.1002/epi4.70269,https://pubmed.ncbi.nlm.nih.gov/42220229/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,39753113,Systematic functional characterization of non-coding regulatory SNPs associated with central obesity.,2025,10.1016/j.ajhg.2024.11.005,https://pubmed.ncbi.nlm.nih.gov/39753113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,37441600,RNF157 attenuates CD4+ T cell-mediated autoimmune response by promoting HDAC1 ubiquitination and degradation.,2023,10.7150/thno.86307,https://pubmed.ncbi.nlm.nih.gov/37441600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,36805591,Differential effects of the LncRNA RNF157-AS1 on epithelial ovarian cancer cells through suppression of DIRAS3- and ULK1-mediated autophagy.,2023,10.1038/s41419-023-05668-5,https://pubmed.ncbi.nlm.nih.gov/36805591/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,36263220,Exosomal RNF157 mRNA from prostate cancer cells contributes to M2 macrophage polarization through destabilizing HDAC1.,2022,10.3389/fonc.2022.1021270,https://pubmed.ncbi.nlm.nih.gov/36263220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,35435923,The E3 Ligase RNF157 Inhibits Lens Epithelial Cell Apoptosis by Negatively Regulating p53 in Age-Related Cataracts.,2022,10.1167/iovs.63.4.11,https://pubmed.ncbi.nlm.nih.gov/35435923/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,37759801,Presenilin-1-Derived Circular RNAs: Neglected Epigenetic Regulators with Various Functions in Alzheimer's Disease.,2023,10.3390/biom13091401,https://pubmed.ncbi.nlm.nih.gov/37759801/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,36457707,Exploring a four-gene risk model based on doxorubicin resistance-associated lncRNAs in hepatocellular carcinoma.,2022,10.3389/fphar.2022.1015842,https://pubmed.ncbi.nlm.nih.gov/36457707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,37542549,Comprehensive analysis of CPSF4-related alternative splice genes in hepatocellular carcinoma.,2023,10.1007/s00432-023-05178-z,https://pubmed.ncbi.nlm.nih.gov/37542549/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,35642209,Identification of Three Prognosis-Related Differentially Expressed lncRNAs Driven by Copy Number Variation in Thyroid Cancer.,2022,10.1155/2022/9203796,https://pubmed.ncbi.nlm.nih.gov/35642209/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,34224310,Identification and validation of a five-lncRNA signature for predicting survival with targeted drug candidates in ovarian cancer.,2021,10.1080/21655979.2021.1946632,https://pubmed.ncbi.nlm.nih.gov/34224310/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,36199791,The Systematic Analyses of RING Finger Gene Signature for Predicting the Prognosis of Patients with Hepatocellular Carcinoma.,2022,10.1155/2022/2466006,https://pubmed.ncbi.nlm.nih.gov/36199791/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,29507613,Up-regulated autophagy: as a protective factor in adipose tissue of WOKW rats with metabolic syndrome.,2018,10.1186/s13098-018-0317-6,https://pubmed.ncbi.nlm.nih.gov/29507613/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,34815695,Whole Exome Sequencing Study in a Family with Type 2 Diabetes Mellitus.,2021,10.2147/ijgm.s335090,https://pubmed.ncbi.nlm.nih.gov/34815695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,28655764,Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle.,2017,10.1074/jbc.m117.792754,https://pubmed.ncbi.nlm.nih.gov/28655764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,36497121,High-Content RNAi Phenotypic Screening Unveils the Involvement of Human Ubiquitin-Related Enzymes in Late Cytokinesis.,2022,10.3390/cells11233862,https://pubmed.ncbi.nlm.nih.gov/36497121/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,25342469,Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157.,2015,10.1038/cdd.2014.163,https://pubmed.ncbi.nlm.nih.gov/25342469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,32175184,A preliminary study of the effect of a high-salt diet on transcriptome dynamics in rat hypothalamic forebrain and brainstem cardiovascular control centers.,2020,10.7717/peerj.8528,https://pubmed.ncbi.nlm.nih.gov/32175184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF157,ENSG00000141576,Unsafe,35178089,Identification and Validation of a Hypoxia-Immune-Based Prognostic mRNA Signature for Oral Squamous Cell Carcinoma.,2022,10.1155/2022/5286251,https://pubmed.ncbi.nlm.nih.gov/35178089/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,41107912,miR-4793-3p predicts poor prognosis and regulates ferroptosis and invasiveness of breast cancer via targeting RNF169.,2025,10.1186/s12957-025-04036-1,https://pubmed.ncbi.nlm.nih.gov/41107912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,40029260,SIRT1/DNMT3B-mediated epigenetic gene silencing in response to phytoestrogens in mammary epithelial cells.,2025,10.1080/15592294.2025.2473770,https://pubmed.ncbi.nlm.nih.gov/40029260/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,41145912,H2BK120ub and its reader RNF169 sequentially regulate replication fork remodeling and stability.,2025,10.1038/s44318-025-00602-1,https://pubmed.ncbi.nlm.nih.gov/41145912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,42314057,PARG Governs a PARylation-Ubiquitination Toggle that Stabilizes RAD51AP1 to Drive Homologous Recombination-Mediated Chemoresistance.,2026,10.1158/0008-5472.can-25-4984,https://pubmed.ncbi.nlm.nih.gov/42314057/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,42398544,Clinicopathologic and molecular characteristics of acral melanomas harboring RARA fusions.,2026,10.1016/j.humpath.2026.106211,https://pubmed.ncbi.nlm.nih.gov/42398544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,36685833,High expression of RNF169 is associated with poor prognosis in pancreatic adenocarcinoma by regulating tumour immune infiltration.,2022,10.3389/fgene.2022.1022626,https://pubmed.ncbi.nlm.nih.gov/36685833/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,33450964,Differential DNA Methylation in Prostate Tumors from Puerto Rican Men.,2021,10.3390/ijms22020733,https://pubmed.ncbi.nlm.nih.gov/33450964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,39893332,Analysing DNA methylation and transcriptomic signatures to predict prostate cancer recurrence risk.,2025,10.1007/s12672-025-01833-8,https://pubmed.ncbi.nlm.nih.gov/39893332/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,31486214,An LTR retrotransposon-derived lncRNA interacts with RNF169 to promote homologous recombination.,2019,10.15252/embr.201847650,https://pubmed.ncbi.nlm.nih.gov/31486214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,30104380,RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair.,2018,10.1073/pnas.1804823115,https://pubmed.ncbi.nlm.nih.gov/30104380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,37409345,Integrative analysis of circadian clock with prognostic and immunological biomarker identification in ovarian cancer.,2023,10.3389/fmolb.2023.1208132,https://pubmed.ncbi.nlm.nih.gov/37409345/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,30773093,DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.,2019,10.1080/15384101.2019.1577525,https://pubmed.ncbi.nlm.nih.gov/30773093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,28325877,Dual-utility NLS drives RNF169-dependent DNA damage responses.,2017,10.1073/pnas.1616602114,https://pubmed.ncbi.nlm.nih.gov/28325877/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,31357500,Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons.,2019,10.3390/cells8080778,https://pubmed.ncbi.nlm.nih.gov/31357500/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,30979931,A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.,2019,10.1038/s41598-019-42445-x,https://pubmed.ncbi.nlm.nih.gov/30979931/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,36077022,DNA Damage Induction Alters the Expression of Ubiquitin and SUMO Regulators in Preimplantation Stage Pig Embryos.,2022,10.3390/ijms23179610,https://pubmed.ncbi.nlm.nih.gov/36077022/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,31544332,An unorthodox partnership in DNA repair pathway choice.,2019,10.15252/embr.201949105,https://pubmed.ncbi.nlm.nih.gov/31544332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,30085123,ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation.,2018,10.1093/nar/gky682,https://pubmed.ncbi.nlm.nih.gov/30085123/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,33022275,Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response.,2020,10.1016/j.molcel.2020.09.017,https://pubmed.ncbi.nlm.nih.gov/33022275/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF169,ENSG00000166439,Unsafe,28406400,The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage.,2017,10.7554/elife.23872,https://pubmed.ncbi.nlm.nih.gov/28406400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,41254487,Genome-wide association study identifies genetic variants associated with single-parity reproductive loss in three commercial pig breeds.,2025,10.1186/s12864-025-12255-9,https://pubmed.ncbi.nlm.nih.gov/41254487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,42038776,Association of Circular RNAs with Sperm Fertility Potential: Implications for Male Infertility Diagnosis.,2025,10.18502/jri.v26i4.21087,https://pubmed.ncbi.nlm.nih.gov/42038776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,37428816,"Two RNA binding proteins, ADAD2 and RNF17, interact to form a heterogeneous population of novel meiotic germ cell granules with developmentally dependent organelle association.",2023,10.1371/journal.pgen.1010519,https://pubmed.ncbi.nlm.nih.gov/37428816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,36930220,ADAD2 interacts with RNF17 in P-bodies to repress the Ping-pong cycle in pachytene piRNA biogenesis.,2023,10.1083/jcb.202206067,https://pubmed.ncbi.nlm.nih.gov/36930220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,36698249,ADAD2 functions in spermiogenesis and piRNA biogenesis in mice.,2023,10.1111/andr.13400,https://pubmed.ncbi.nlm.nih.gov/36698249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,35999765,Histology study and transcriptome analysis of the testis of Loach(Misgurnus anguillicaudatus) in response to phenanthrene exposure.,2022,10.1016/j.ecoenv.2022.113950,https://pubmed.ncbi.nlm.nih.gov/35999765/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,38911262,Analysis of 206 whole-genome resequencing reveals selection signatures associated with breed-specific traits in Hu sheep.,2024,10.1111/eva.13697,https://pubmed.ncbi.nlm.nih.gov/38911262/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,32054438,"Population-specific, recent positive directional selection suggests adaptation of human male reproductive genes to different environmental conditions.",2020,10.1186/s12862-019-1575-0,https://pubmed.ncbi.nlm.nih.gov/32054438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,24586802,"STK31/TDRD8, a germ cell-specific factor, is dispensable for reproduction in mice.",2014,10.1371/journal.pone.0089471,https://pubmed.ncbi.nlm.nih.gov/24586802/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,39596622,"Genome-Wide Association Studies and Runs of Homozygosity Reveals Genetic Markers Associated with Reproductive Performance in Korean Duroc, Landrace, and Yorkshire Breeds.",2024,10.3390/genes15111422,https://pubmed.ncbi.nlm.nih.gov/39596622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,37370521,"Evaluation of the Genetic Diversity, Population Structure and Selection Signatures of Three Native Chinese Pig Populations.",2023,10.3390/ani13122010,https://pubmed.ncbi.nlm.nih.gov/37370521/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,35477688,Differentially Expressed Genes in Period 2-Overexpressing Mice Striatum May Underlie Their Lower Sensitivity to Methamphetamine Addiction-Like Behavior.,2022,10.4062/biomolther.2021.184,https://pubmed.ncbi.nlm.nih.gov/35477688/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,24377578,"Expression analysis of two cancer-testis genes, FBXO39 and TDRD4, in breast cancer tissues and cell lines.",2014,10.7314/apjcp.2013.14.11.6625,https://pubmed.ncbi.nlm.nih.gov/24377578/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,33238277,Fertility Relevance Probability Analysis Shortlists Genetic Markers for Male Fertility Impairment.,2020,10.1159/000511117,https://pubmed.ncbi.nlm.nih.gov/33238277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,33228611,Development and validation of an RNA binding protein-associated prognostic model for hepatocellular carcinoma.,2020,10.1186/s12885-020-07625-3,https://pubmed.ncbi.nlm.nih.gov/33228611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,37752425,Genome-wide landscape of runs of homozygosity and differentiation across Egyptian goat breeds.,2023,10.1186/s12864-023-09679-6,https://pubmed.ncbi.nlm.nih.gov/37752425/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,26115953,RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.,2015,10.1101/gad.265215.115,https://pubmed.ncbi.nlm.nih.gov/26115953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,27903633,"An E2-guided E3 Screen Identifies the RNF17-UBE2U Pair as Regulator of the Radiosensitivity, Immunodeficiency, Dysmorphic Features, and Learning Difficulties (RIDDLE) Syndrome Protein RNF168.",2017,10.1074/jbc.m116.758854,https://pubmed.ncbi.nlm.nih.gov/27903633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,21515969,Tudor domain-containing protein 4 as a potential cancer/testis antigen in liver cancer.,2011,10.1620/tjem.224.41,https://pubmed.ncbi.nlm.nih.gov/21515969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF17,ENSG00000132972,Unsafe,30767091,"Induction of goat bone marrow mesenchymal stem cells into putative male germ cells using mRNA for STRA8, BOULE and DAZL.",2019,10.1007/s10616-019-00304-7,https://pubmed.ncbi.nlm.nih.gov/30767091/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,41942761,Hypertonicity-induced RNF183 targets NKCC1 to protect kidney collecting duct cells but induces apoptosis in colon cells.,2026,10.1038/s42003-026-09766-w,https://pubmed.ncbi.nlm.nih.gov/41942761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,40072093,Modification of RNF183 via m6A Methylation Mediates Podocyte Dysfunction in Diabetic Nephropathy by Regulating PKM2 Ubiquitination and Degradation.,2025,10.3390/cells14050365,https://pubmed.ncbi.nlm.nih.gov/40072093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,38044546,RNF183 Promotes Colon Cancer Cell Stemness through Fatty Acid Oxidation.,2024,10.1080/01635581.2023.2286700,https://pubmed.ncbi.nlm.nih.gov/38044546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,38212299,FBXO5-mediated RNF183 degradation prevents endoplasmic reticulum stress-induced apoptosis and promotes colon cancer progression.,2024,10.1038/s41419-024-06421-2,https://pubmed.ncbi.nlm.nih.gov/38212299/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,37258572,The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression.,2023,10.1038/s12276-023-00997-z,https://pubmed.ncbi.nlm.nih.gov/37258572/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,39742022,Identification of Endoplasmic Reticulum Stress-Related Biomarkers in Coronary Artery Disease.,2024,10.1155/2024/4664731,https://pubmed.ncbi.nlm.nih.gov/39742022/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,40988925,A lipid metabolism and lysosome-based risk signature for prognosis and immune response prediction in uterine corpus endometrial carcinoma.,2025,10.3389/fgene.2025.1594682,https://pubmed.ncbi.nlm.nih.gov/40988925/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,35104174,Knockdown of RNF183 suppressed proliferation of lung adenocarcinoma cells via inactivating the STAT3 signaling pathway.,2022,10.1080/15384101.2022.2035617,https://pubmed.ncbi.nlm.nih.gov/35104174/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,40215164,High-glucose-associated YTHDC1 lactylation reduces the sensitivity of bladder cancer to enfortumab vedotin therapy.,2025,10.1016/j.celrep.2025.115545,https://pubmed.ncbi.nlm.nih.gov/40215164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,42565562,In-depth analysis of retinal RNA transcriptome sequencing in a rat model of hypertensive retinopathy.,2026,10.11817/j.issn.1672-7347.2026.250532,https://pubmed.ncbi.nlm.nih.gov/42565562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,34777536,Moxibustion Inhibits the Expression of Colonic NLRP3 through miR7/RNF183/NF-κB Signaling Pathway in UC Rats.,2021,10.1155/2021/6519063,https://pubmed.ncbi.nlm.nih.gov/34777536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,33324448,"RNF183 Is a Prognostic Biomarker and Correlates With Tumor Purity, Immune Infiltrates in Uterine Corpus Endometrial Carcinoma.",2020,10.3389/fgene.2020.595733,https://pubmed.ncbi.nlm.nih.gov/33324448/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,35715412,Itch and autophagy-mediated NF-κB activation contributes to inhibition of cathepsin D-induced sensitizing effect on anticancer drugs.,2022,10.1038/s41419-022-05011-4,https://pubmed.ncbi.nlm.nih.gov/35715412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,35121737,Cathepsin D as a potential therapeutic target to enhance anticancer drug-induced apoptosis via RNF183-mediated destabilization of Bcl-xL in cancer cells.,2022,10.1038/s41419-022-04581-7,https://pubmed.ncbi.nlm.nih.gov/35121737/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,32486221,"The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function.",2020,10.3390/ijms21113921,https://pubmed.ncbi.nlm.nih.gov/32486221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,30413537,NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells.,2019,10.1074/jbc.ra118.002896,https://pubmed.ncbi.nlm.nih.gov/30413537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,31889078,Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation.,2019,10.1038/s41598-019-56748-6,https://pubmed.ncbi.nlm.nih.gov/31889078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,31732153,"Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.",2020,10.1016/j.bbrc.2019.11.001,https://pubmed.ncbi.nlm.nih.gov/31732153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,40158428,The characterization and validation of regulated cell death-related genes in chronic rhinosinusitis with nasal polyps.,2025,10.1016/j.intimp.2025.114509,https://pubmed.ncbi.nlm.nih.gov/40158428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,36428665,Construction of Oxidative Stress-Related Genes Risk Model Predicts the Prognosis of Uterine Corpus Endometrial Cancer Patients.,2022,10.3390/cancers14225572,https://pubmed.ncbi.nlm.nih.gov/36428665/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,36330680,Whole-genome assembly and annotation for the little yellow croaker (Larimichthys polyactis) provide insights into the evolution of hermaphroditism and gonochorism.,2023,10.1111/1755-0998.13731,https://pubmed.ncbi.nlm.nih.gov/36330680/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,28756770,Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells.,2017,10.1186/s40880-017-0228-1,https://pubmed.ncbi.nlm.nih.gov/28756770/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,31036566,EWSR1-FLI1 Activation of the Cancer/Testis Antigen FATE1 Promotes Ewing Sarcoma Survival.,2019,10.1128/mcb.00138-19,https://pubmed.ncbi.nlm.nih.gov/31036566/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF183,ENSG00000165188,Unsafe,29300766,"Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183.",2018,10.1371/journal.pone.0190407,https://pubmed.ncbi.nlm.nih.gov/29300766/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF212B,ENSG00000215277,Unsafe,38865271,RNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse.,2024,10.1073/pnas.2320995121,https://pubmed.ncbi.nlm.nih.gov/38865271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF212B,ENSG00000215277,Unsafe,40259604,A variant in RNF212B may contribute to female infertility and recurrent pregnancy loss.,2025,10.1016/j.xhgg.2025.100443,https://pubmed.ncbi.nlm.nih.gov/40259604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF212B,ENSG00000215277,Unsafe,40426007,Genomic and chromosomal architectures underlying fertility maintenance in the testes of intergeneric homoploid hybrids.,2025,10.1007/s11427-024-2868-y,https://pubmed.ncbi.nlm.nih.gov/40426007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF212B,ENSG00000215277,Unsafe,37124137,A pathogenic variant in the uncharacterized RNF212B gene results in severe aneuploidy male infertility and repeated IVF failure.,2023,10.1016/j.xhgg.2023.100189,https://pubmed.ncbi.nlm.nih.gov/37124137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF212B,ENSG00000215277,Unsafe,39761402,Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis.,2025,10.1073/pnas.2412961121,https://pubmed.ncbi.nlm.nih.gov/39761402/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF212B,ENSG00000215277,Unsafe,41118211,HEIP1 orchestrates pro-crossover protein activity during mammalian meiosis.,2025,10.1073/pnas.2515747122,https://pubmed.ncbi.nlm.nih.gov/41118211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF212B,ENSG00000215277,Unsafe,41102672,Genome landscape and genetic architecture of recombination in domestic goats (Capra hircus).,2025,10.1186/s12711-025-01001-0,https://pubmed.ncbi.nlm.nih.gov/41102672/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF212B,ENSG00000215277,Unsafe,40515540,An Increase in Male Recombination Rate With Age in Dairy Cattle Is Heritable and Polygenic.,2026,10.1111/jbg.12948,https://pubmed.ncbi.nlm.nih.gov/40515540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF212B,ENSG00000215277,Unsafe,29764960,A Genomic Region Containing REC8 and RNF212B Is Associated with Individual Recombination Rate Variation in a Wild Population of Red Deer (Cervus elaphus).,2018,10.1534/g3.118.200063,https://pubmed.ncbi.nlm.nih.gov/29764960/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF212B,ENSG00000215277,Unsafe,27516620,"Coding and noncoding variants in HFM1, MLH3, MSH4, MSH5, RNF212, and RNF212B affect recombination rate in cattle.",2016,10.1101/gr.204214.116,https://pubmed.ncbi.nlm.nih.gov/27516620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF212B,ENSG00000215277,Unsafe,27029733,Conserved Genetic Architecture Underlying Individual Recombination Rate Variation in a Wild Population of Soay Sheep (Ovis aries).,2016,10.1534/genetics.115.185553,https://pubmed.ncbi.nlm.nih.gov/27029733/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF32,ENSG00000105982,Unsafe,40755799,&lt;i&gt;Rnf32&lt;/i&gt; is not essential for spermatogenesis and male fertility in mice.,2025,10.7717/peerj.19794,https://pubmed.ncbi.nlm.nih.gov/40755799/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF32,ENSG00000105982,Unsafe,41387204,"Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1&lt;sup&gt;+&lt;/sup&gt; Macrophages to Foster Liver Metastasis, Targeted by Indole-3-Acetic Acid.",2026,10.1002/advs.202519735,https://pubmed.ncbi.nlm.nih.gov/41387204/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF32,ENSG00000105982,Unsafe,42397623,Comprehensive identification of three key genes and three key DNA methylation CpG sites associated with prognosis and prediction in colon adenocarcinoma.,2026,10.1007/s12672-026-05521-z,https://pubmed.ncbi.nlm.nih.gov/42397623/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF32,ENSG00000105982,Unsafe,41167191,The E3 ligase RNF32 controls the IκB kinase complex and NF-κB signaling in intestinal stem cells.,2025,10.1016/j.molcel.2025.10.005,https://pubmed.ncbi.nlm.nih.gov/41167191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF32,ENSG00000105982,Unsafe,42871805,Epigenetic changes differentiate between endogenous ageing and photoageing in skin and can detect sun-protection factor cream effects in a 5-month interventional study.,2026,10.1093/eep/dvag025,https://pubmed.ncbi.nlm.nih.gov/42871805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF32,ENSG00000105982,Unsafe,38270646,Prognosis and immunotherapy response prediction based on M2 macrophage-related genes in colon cancer.,2024,10.1007/s00432-023-05573-6,https://pubmed.ncbi.nlm.nih.gov/38270646/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF32,ENSG00000105982,Unsafe,38898815,Development and Validation of a Prognostic Model based on 11 E3-related Genes for Colon Cancer Patients.,2024,10.2174/0113816128292398240306160051,https://pubmed.ncbi.nlm.nih.gov/38898815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF32,ENSG00000105982,Unsafe,37434691,A signature of cuproptosis-related lncRNAs predicts prognosis and provides basis for future anti-tumor drug development in breast cancer.,2023,10.21037/tcr-22-2702,https://pubmed.ncbi.nlm.nih.gov/37434691/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF32,ENSG00000105982,Unsafe,22666536,Comparative genomics of the Hedgehog loci in chordates and the origins of Shh regulatory novelties.,2012,10.1038/srep00433,https://pubmed.ncbi.nlm.nih.gov/22666536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF32,ENSG00000105982,Unsafe,25228972,RING finger proteins are involved in the progression of barrett esophagus to esophageal adenocarcinoma: a preliminary study.,2014,10.5009/gnl13133,https://pubmed.ncbi.nlm.nih.gov/25228972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF32,ENSG00000105982,Unsafe,25252942,Mapping the Shh long-range regulatory domain.,2014,10.1242/dev.108480,https://pubmed.ncbi.nlm.nih.gov/25252942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF32,ENSG00000105982,Unsafe,11890671,"A double RING-H2 domain in RNF32, a gene expressed during sperm formation.",2002,10.1006/bbrc.2002.6612,https://pubmed.ncbi.nlm.nih.gov/11890671/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF32,ENSG00000105982,Unsafe,19066618,Mutation analysis of a large Chinese pedigree with congenital preaxial polydactyly.,2009,10.1038/ejhg.2008.240,https://pubmed.ncbi.nlm.nih.gov/19066618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF32,ENSG00000105982,Unsafe,16646086,"High incidence of t(7;12)(q36;p13) in infant AML but not in infant ALL, with a dismal outcome and ectopic expression of HLXB9.",2006,10.1002/gcc.20335,https://pubmed.ncbi.nlm.nih.gov/16646086/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,41902231,Tree Shrew Genome-Wide CRISPR Screen Identifies RNF6 as a Proviral Host Factor for Zika Virus Replication in Brain Microvascular Endothelial Cells.,2026,10.3390/v18030323,https://pubmed.ncbi.nlm.nih.gov/41902231/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,42587728,From PLP1 Misfolding to Oligodendrocyte Degeneration: A Proteostasis-Centered Framework for Pelizaeus-Merzbacher Disease.,2026,10.3390/cells15151318,https://pubmed.ncbi.nlm.nih.gov/42587728/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,41616518,RNF6 activates JNK/c-JUN pathway in ovarian cancer by promoting K48-linked NME4 ubiquitination.,2026,10.1016/j.prp.2026.156366,https://pubmed.ncbi.nlm.nih.gov/41616518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,39938447,RNF6 promotes cell proliferation of glioblastoma by targeting ubiquitin-mediated degradation of p27.,2025,10.1016/j.bbrc.2025.151460,https://pubmed.ncbi.nlm.nih.gov/39938447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,40231770,CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1-Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis.,2025,10.1002/advs.202414550,https://pubmed.ncbi.nlm.nih.gov/40231770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,39551725,The E3 ubiquitin ligase RNF6 facilitates the progression of cervical cancer by inhibiting the Hippo/Yap pathway.,2024,10.1186/s13008-024-00136-8,https://pubmed.ncbi.nlm.nih.gov/39551725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,39918413,RNF6 Inhibits Lung Adenocarcinoma Cell Proliferation by Promoting Cyclin D2 Degradation.,2025,10.1158/1541-7786.mcr-24-0703,https://pubmed.ncbi.nlm.nih.gov/39918413/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,37904524,RNF6 promotes gastric cancer progression by regulating CCNA1/CREBBP transcription.,2023,10.1080/15384101.2023.2275899,https://pubmed.ncbi.nlm.nih.gov/37904524/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,36845743,RNF6 activates TGF-β1/c-Myb pathway to promote EMT in esophageal squamous cell carcinoma.,2023,10.3389/fonc.2023.1081333,https://pubmed.ncbi.nlm.nih.gov/36845743/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,36622199,PLP1 gene mutations cause spastic paraplegia type 2 in three families.,2023,10.1002/acn3.51722,https://pubmed.ncbi.nlm.nih.gov/36622199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,37475517,Microdeletion in distal PLP1 enhancers causes hereditary spastic paraplegia 2.,2023,10.1002/acn3.51848,https://pubmed.ncbi.nlm.nih.gov/37475517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,35046680,RNF6 Targeted by miR-26a-5p Protects Pancreatic β-Cell Function Against Type 2 Diabetes.,2022,10.2147/dmso.s335088,https://pubmed.ncbi.nlm.nih.gov/35046680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,34970341,RNF6 promotes the migration and invasion of breast cancer by promoting the ubiquitination and degradation of MST1.,2022,10.3892/etm.2021.11041,https://pubmed.ncbi.nlm.nih.gov/34970341/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,34611311,RING-finger protein 6 promotes colorectal tumorigenesis by transcriptionally activating SF3B2.,2021,10.1038/s41388-021-01872-9,https://pubmed.ncbi.nlm.nih.gov/34611311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,34081837,Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling.,2021,10.1002/2211-5463.13216,https://pubmed.ncbi.nlm.nih.gov/34081837/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,35814430,Glaucocalyxin A Inhibits the Malignancies of Gastric Cancer Cells by Downregulating MDM2 and RNF6 via MiR-3658 and the SMG1-UPF mRNA Decay Pathway.,2022,10.3389/fonc.2022.871169,https://pubmed.ncbi.nlm.nih.gov/35814430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,35973638,E3 ubiquitin ligase RNF6 promotes antiviral immune responses through enhancing the expression of interferon stimulated genes in myeloid cells.,2022,10.1016/j.clim.2022.109099,https://pubmed.ncbi.nlm.nih.gov/35973638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,35456636,Regulation of p27 (Kip1) by Ubiquitin E3 Ligase RNF6.,2022,10.3390/pharmaceutics14040802,https://pubmed.ncbi.nlm.nih.gov/35456636/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,32955171,Inhibition of RNF6 alleviates traumatic brain injury by suppressing STAT3 signaling in rats.,2020,10.1002/brb3.1847,https://pubmed.ncbi.nlm.nih.gov/32955171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,36672024,In Silico Structural Analysis Predicting the Pathogenicity of PLP1 Mutations in Multiple Sclerosis.,2022,10.3390/brainsci13010042,https://pubmed.ncbi.nlm.nih.gov/36672024/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,35822825,RNF6 as an Oncogene and Potential Therapeutic Target-A Review.,2020,10.3390/biotech9040022,https://pubmed.ncbi.nlm.nih.gov/35822825/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,37324936,TRIM26 promotes non-small cell lung cancer survival by inducing PBX1 degradation.,2023,10.7150/ijbs.81726,https://pubmed.ncbi.nlm.nih.gov/37324936/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,29997504,Saponins From Paris forrestii (Takht.) H. Li Display Potent Activity Against Acute Myeloid Leukemia by Suppressing the RNF6/AKT/mTOR Signaling Pathway.,2018,10.3389/fphar.2018.00673,https://pubmed.ncbi.nlm.nih.gov/29997504/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,30195779,"Morpholino Antisense Oligomers as a Potential Therapeutic Option for the Correction of Alternative Splicing in PMD, SPG2, and HEMS.",2018,10.1016/j.omtn.2018.05.019,https://pubmed.ncbi.nlm.nih.gov/30195779/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,30314286,PLP1 Mutations in Patients with Multiple Sclerosis: Identification of a New Mutation and Potential Pathogenicity of the Mutations.,2018,10.3390/jcm7100342,https://pubmed.ncbi.nlm.nih.gov/30314286/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,32765386,Brain Magnetic Spectroscopy Imaging and Hereditary Spastic Paraplegia: A Focused Systematic Review on Current Landmarks and Future Perspectives.,2020,10.3389/fneur.2020.00515,https://pubmed.ncbi.nlm.nih.gov/32765386/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,27249653,Establishment of a Wheat Cell-Free Synthesized Protein Array Containing 250 Human and Mouse E3 Ubiquitin Ligases to Identify Novel Interaction between E3 Ligases and Substrate Proteins.,2016,10.1371/journal.pone.0156718,https://pubmed.ncbi.nlm.nih.gov/27249653/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,24314267,Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain.,2013,10.1186/1742-2094-10-146,https://pubmed.ncbi.nlm.nih.gov/24314267/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,19345326,Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination.,2009,10.1016/j.ccr.2009.02.021,https://pubmed.ncbi.nlm.nih.gov/19345326/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNF6,ENSG00000127870,Unsafe,18368307,Cloning and identification of a novel RNF6 transcriptional splice variant Spg2 in human development.,2008,10.1007/s11427-008-0047-3,https://pubmed.ncbi.nlm.nih.gov/18368307/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNFT2,ENSG00000135119,Unsafe,40632345,RNFT2 promotes malignancy of triple-negative breast cancer and predicts poor outcomes.,2025,10.1007/s10735-025-10506-3,https://pubmed.ncbi.nlm.nih.gov/40632345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNFT2,ENSG00000135119,Unsafe,40097779,Silencing of RNFT2 suppresses cell proliferation and migration through mTORC1 signaling pathway in gastric cancer.,2025,10.1007/s00726-025-03449-2,https://pubmed.ncbi.nlm.nih.gov/40097779/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNFT2,ENSG00000135119,Unsafe,36199110,N6-methyladenosine-related single-nucleotide polymorphism analyses identify oncogene RNFT2 in bladder cancer.,2022,10.1186/s12935-022-02701-z,https://pubmed.ncbi.nlm.nih.gov/36199110/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNFT2,ENSG00000135119,Unsafe,31990690,The RNFT2/IL-3Rα axis regulates IL-3 signaling and innate immunity.,2020,10.1172/jci.insight.133652,https://pubmed.ncbi.nlm.nih.gov/31990690/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNFT2,ENSG00000135119,Unsafe,37542549,Comprehensive analysis of CPSF4-related alternative splice genes in hepatocellular carcinoma.,2023,10.1007/s00432-023-05178-z,https://pubmed.ncbi.nlm.nih.gov/37542549/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNFT2,ENSG00000135119,Unsafe,33517265,Tissue RNFT2 Expression Levels Are Associated With Peritoneal Recurrence and Poor Prognosis in Gastric Cancer.,2021,10.21873/anticanres.14812,https://pubmed.ncbi.nlm.nih.gov/33517265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNFT2,ENSG00000135119,Unsafe,31816601,Identification of molecular correlations of RBM8A with autophagy in Alzheimer's disease.,2019,10.18632/aging.102571,https://pubmed.ncbi.nlm.nih.gov/31816601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNFT2,ENSG00000135119,Unsafe,31568004,Identification of gene and microRNA changes in response to smoking in human airway epithelium by bioinformatics analyses.,2019,10.1097/md.0000000000017267,https://pubmed.ncbi.nlm.nih.gov/31568004/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RNFT2,ENSG00000135119,Unsafe,34762840,Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma.,2021,10.1016/s2352-4642(21)00268-6,https://pubmed.ncbi.nlm.nih.gov/34762840/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,40904610,&lt;i&gt;ROPN1&lt;/i&gt; Gene Expression as a Prognostic and Predictive Biomarker in Aggressive Breast Cancer: Clinical Implications and Survival Association.,2025,10.4274/ejbh.galenos.2025.2025-6-2,https://pubmed.ncbi.nlm.nih.gov/40904610/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,39172012,TCR-Engineered T Cells Directed against Ropporin-1 Constitute a Safe and Effective Treatment for Triple-Negative Breast Cancer.,2024,10.1158/2159-8290.cd-24-0168,https://pubmed.ncbi.nlm.nih.gov/39172012/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,33918976,Ropporin-1 and 1B Are Widely Expressed in Human Melanoma and Evoke Strong Humoral Immune Responses.,2021,10.3390/cancers13081805,https://pubmed.ncbi.nlm.nih.gov/33918976/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,37410071,Sperm immotility is associated with epididymis metabolism disorder in mice under obstructive azoospermia.,2023,10.1096/fj.202201862rr,https://pubmed.ncbi.nlm.nih.gov/37410071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,38799722,Sperm long non-coding RNAs as markers for ram fertility.,2024,10.3389/fvets.2024.1337939,https://pubmed.ncbi.nlm.nih.gov/38799722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,32427399,Rhophilin-associated tail protein 1 promotes migration and metastasis in triple negative breast cancer via activation of RhoA.,2020,10.1096/fj.201903281r,https://pubmed.ncbi.nlm.nih.gov/32427399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,34336830,Protein Identification of Spermatozoa and Seminal Plasma in Bottlenose Dolphin (Tursiops truncatus).,2021,10.3389/fcell.2021.673961,https://pubmed.ncbi.nlm.nih.gov/34336830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,34782661,Immune classification and identification of prognostic genes for uveal melanoma based on six immune cell signatures.,2021,10.1038/s41598-021-01627-2,https://pubmed.ncbi.nlm.nih.gov/34782661/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,34336820,Comparative Proteomics and Phosphoproteomics Analysis Reveal the Possible Breed Difference in Yorkshire and Duroc Boar Spermatozoa.,2021,10.3389/fcell.2021.652809,https://pubmed.ncbi.nlm.nih.gov/34336820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,29247344,Molecular study of human sperm RNA: Ropporin and CABYR in asthenozoospermia.,2018,10.1007/s40618-017-0804-x,https://pubmed.ncbi.nlm.nih.gov/29247344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,33746934,"Transcriptome Analysis Revealed Overlapping and Special Regulatory Roles of RpoN1 and RpoN2 in Motility, Virulence, and Growth of Xanthomonas oryzae pv. oryzae.",2021,10.3389/fmicb.2021.653354,https://pubmed.ncbi.nlm.nih.gov/33746934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,26885621,Novel potential serological prostate cancer biomarkers using CT100+ cancer antigen microarray platform in a multi-cultural South African cohort.,2016,10.18632/oncotarget.7359,https://pubmed.ncbi.nlm.nih.gov/26885621/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,23303679,"Loss of R2D2 proteins ROPN1 and ROPN1L causes defects in murine sperm motility, phosphorylation, and fibrous sheath integrity.",2013,10.1095/biolreprod.112.105262,https://pubmed.ncbi.nlm.nih.gov/23303679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,22021175,Loss of ASP but not ROPN1 reduces mammalian ciliary motility.,2012,10.1002/cm.20539,https://pubmed.ncbi.nlm.nih.gov/22021175/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,25124046,Opisthorchis viverrini: analysis of the sperm-specific rhophilin associated tail protein 1-like.,2014,10.1016/j.actatropica.2014.08.002,https://pubmed.ncbi.nlm.nih.gov/25124046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,21898529,Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia.,2011,10.1002/ajh.22141,https://pubmed.ncbi.nlm.nih.gov/21898529/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,23799842,Diagnostic SOX10 gene signatures in salivary adenoid cystic and breast basal-like carcinomas.,2013,10.1038/bjc.2013.326,https://pubmed.ncbi.nlm.nih.gov/23799842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,20107840,Kalirin: a novel genetic risk factor for ischemic stroke.,2010,10.1007/s00439-010-0790-y,https://pubmed.ncbi.nlm.nih.gov/20107840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,17928627,Identification and characterization of RHOA-interacting proteins in bovine spermatozoa.,2008,10.1095/biolreprod.107.062943,https://pubmed.ncbi.nlm.nih.gov/17928627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,18421703,Protein kinase A RII-like (R2D2) proteins exhibit differential localization and AKAP interaction.,2008,10.1002/cm.20279,https://pubmed.ncbi.nlm.nih.gov/18421703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1,ENSG00000065371,Unsafe,17551920,A yeast two-hybrid system using Sp17 identified Ropporin as a novel cancer-testis antigen in hematologic malignancies.,2007,10.1002/ijc.22842,https://pubmed.ncbi.nlm.nih.gov/17551920/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1B,ENSG00000114547,Unsafe,37118964,Differential Proteomic Analysis of Human Sperm: A Systematic Review to Identify Candidate Targets to Monitor Sperm Quality.,2024,10.5534/wjmh.220262,https://pubmed.ncbi.nlm.nih.gov/37118964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1B,ENSG00000114547,Unsafe,33918976,Ropporin-1 and 1B Are Widely Expressed in Human Melanoma and Evoke Strong Humoral Immune Responses.,2021,10.3390/cancers13081805,https://pubmed.ncbi.nlm.nih.gov/33918976/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1B,ENSG00000114547,Unsafe,36750254,Suitability of tumor-associated antibodies as predictive biomarker for response to immune checkpoint inhibitors in patients with melanoma: a short report.,2023,10.1136/jitc-2022-006467,https://pubmed.ncbi.nlm.nih.gov/36750254/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1B,ENSG00000114547,Unsafe,35663320,The Role of Testosterone in Spermatogenesis: Lessons From Proteome Profiling of Human Spermatozoa in Testosterone Deficiency.,2022,10.3389/fendo.2022.852661,https://pubmed.ncbi.nlm.nih.gov/35663320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1B,ENSG00000114547,Unsafe,39406274,Investigating the effects of COVID-19 on sperm in male smokers: A prospective integrated proteomic and metabolomic study.,2024,10.1016/j.reprotox.2024.108734,https://pubmed.ncbi.nlm.nih.gov/39406274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1B,ENSG00000114547,Unsafe,34389675,Drivers and suppressors of triple-negative breast cancer.,2021,10.1073/pnas.2104162118,https://pubmed.ncbi.nlm.nih.gov/34389675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1B,ENSG00000114547,Unsafe,23799842,Diagnostic SOX10 gene signatures in salivary adenoid cystic and breast basal-like carcinomas.,2013,10.1038/bjc.2013.326,https://pubmed.ncbi.nlm.nih.gov/23799842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,42079374,Insights into Human Ciliopathies: Gene Silencing of &lt;i&gt;ropn1l&lt;/i&gt; and &lt;i&gt;tex9&lt;/i&gt; in &lt;i&gt;Schmidtea&lt;/i&gt; &lt;i&gt;mediterranea&lt;/i&gt; Indicate Association with Ciliary Structure and Motility.,2026,10.17912/micropub.biology.002035,https://pubmed.ncbi.nlm.nih.gov/42079374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,41516134,NSUN7 Regulates Sperm Flagella Formation at All Stages of Spermiogenesis.,2025,10.3390/ijms27010257,https://pubmed.ncbi.nlm.nih.gov/41516134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,40538010,Machine Learning-Driven Discovery of TRIM Genes as Diagnostic Biomarkers for Idiopathic Pulmonary Fibrosis.,2025,10.12659/msm.948510,https://pubmed.ncbi.nlm.nih.gov/40538010/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,38027210,RNA sequencing profiles reveals progressively reduced spermatogenesis with progression in adult cryptorchidism.,2023,10.3389/fendo.2023.1271724,https://pubmed.ncbi.nlm.nih.gov/38027210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,42312861,&lt;i&gt;Mycoplasma hyopneumoniae&lt;/i&gt; modulates ciliary function and epithelial integrity in air-liquid interface porcine respiratory epithelial cells (ALI-PRECs).,2026,10.1128/spectrum.01998-25,https://pubmed.ncbi.nlm.nih.gov/42312861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,39936988,Single-Cell RNA Sequencing on Formalin-Fixed and Paraffin-Embedded (FFPE) Tissue Identified Multi-Ciliary Cells in Breast Cancer.,2025,10.3390/cells14030197,https://pubmed.ncbi.nlm.nih.gov/39936988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,39849482,IQUB mutation induces radial spoke 1 deficiency causing asthenozoospermia with normal sperm morphology in humans and mice.,2025,10.1186/s12964-025-02043-z,https://pubmed.ncbi.nlm.nih.gov/39849482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,40231527,Cilia Plays a Pivotal Role in the Hypersecretion of Airway Mucus in Mice,2024,10.2174/0118761429368288250401054301,https://pubmed.ncbi.nlm.nih.gov/40231527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,37354751,"Comparative transcriptome analysis of gonads in male and female Pseudobagrus ussuriensis (Bagridae, Siluriformes).",2023,10.1016/j.cbd.2023.101105,https://pubmed.ncbi.nlm.nih.gov/37354751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,35173218,Using publicly available transcriptomic data to identify mechanistic and diagnostic biomarkers in azoospermia and overall male infertility.,2022,10.1038/s41598-022-06476-1,https://pubmed.ncbi.nlm.nih.gov/35173218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,33067535,Evaluation of blood gene expression levels in facioscapulohumeral muscular dystrophy patients.,2020,10.1038/s41598-020-74687-5,https://pubmed.ncbi.nlm.nih.gov/33067535/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,32054438,"Population-specific, recent positive directional selection suggests adaptation of human male reproductive genes to different environmental conditions.",2020,10.1186/s12862-019-1575-0,https://pubmed.ncbi.nlm.nih.gov/32054438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,32871643,Evaluation of Rhophilin Associated Tail Protein (ROPN1L) in the Human Liver Fluke Opisthorchis viverrini for Diagnostic Approach.,2020,10.3347/kjp.2020.58.4.475,https://pubmed.ncbi.nlm.nih.gov/32871643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,34360666,Bull Sperm Capacitation Is Accompanied by Redox Modifications of Proteins.,2021,10.3390/ijms22157903,https://pubmed.ncbi.nlm.nih.gov/34360666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,23303679,"Loss of R2D2 proteins ROPN1 and ROPN1L causes defects in murine sperm motility, phosphorylation, and fibrous sheath integrity.",2013,10.1095/biolreprod.112.105262,https://pubmed.ncbi.nlm.nih.gov/23303679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,36977161,Production and Immunological Characterization of scFv Specific to Epitope of Opisthorchis viverrini Rhophilin-Associated Tail Protein 1-like (OvROPN1L).,2023,10.3390/tropicalmed8030160,https://pubmed.ncbi.nlm.nih.gov/36977161/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,25124046,Opisthorchis viverrini: analysis of the sperm-specific rhophilin associated tail protein 1-like.,2014,10.1016/j.actatropica.2014.08.002,https://pubmed.ncbi.nlm.nih.gov/25124046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,28203405,Weighted gene co-expression network analysis in identification of metastasis-related genes of lung squamous cell carcinoma based on the Cancer Genome Atlas database.,2017,10.21037/jtd.2017.01.04,https://pubmed.ncbi.nlm.nih.gov/28203405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,30194076,Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A.,2018,10.21873/cgp.20094,https://pubmed.ncbi.nlm.nih.gov/30194076/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ROPN1L,ENSG00000145491,Unsafe,24219008,Dynamically regulated miRNA-mRNA networks revealed by exercise.,2013,10.1186/1472-6793-13-9,https://pubmed.ncbi.nlm.nih.gov/24219008/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPA4,ENSG00000204086,Unsafe,41053718,ACOXL-AS1's pan-cancer dynamics and its proliferative impact on endometrial endometrioid carcinoma.,2025,10.1186/s12885-025-15005-y,https://pubmed.ncbi.nlm.nih.gov/41053718/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPA4,ENSG00000204086,Unsafe,41079096,"A case report on IDH-mutant astrocytoma, CNS WHO grade 4: multi-omic characterization of untreated clinical progression.",2025,10.3389/fonc.2025.1557245,https://pubmed.ncbi.nlm.nih.gov/41079096/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPA4,ENSG00000204086,Unsafe,37827155,Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability.,2023,10.1016/j.cell.2023.09.008,https://pubmed.ncbi.nlm.nih.gov/37827155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPA4,ENSG00000204086,Unsafe,19942684,A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression.,2010,10.1093/nar/gkp1062,https://pubmed.ncbi.nlm.nih.gov/19942684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPA4,ENSG00000204086,Unsafe,19996105,An alternative form of replication protein a expressed in normal human tissues supports DNA repair.,2010,10.1074/jbc.m109.079418,https://pubmed.ncbi.nlm.nih.gov/19996105/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPA4,ENSG00000204086,Unsafe,19116208,An alternative form of replication protein a prevents viral replication in vitro.,2009,10.1074/jbc.m808963200,https://pubmed.ncbi.nlm.nih.gov/19116208/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPA4,ENSG00000204086,Unsafe,27876891,Genetic variations in the PI3K-PTEN-AKT-mTOR pathway are associated with distant metastasis in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy.,2016,10.1038/srep37576,https://pubmed.ncbi.nlm.nih.gov/27876891/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPA4,ENSG00000204086,Unsafe,15131195,"Detection of a rickettsia closely related to Rickettsia aeschlimannii, ""Rickettsia heilongjiangensis,"" Rickettsia sp. strain RpA4, and Ehrlichia muris in ticks collected in Russia and Kazakhstan.",2004,10.1128/jcm.42.5.2221-2223.2004,https://pubmed.ncbi.nlm.nih.gov/15131195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPA4,ENSG00000204086,Unsafe,21643987,Analysis of DNA repair gene polymorphisms and survival in low-grade and anaplastic gliomas.,2011,10.1007/s11060-011-0614-5,https://pubmed.ncbi.nlm.nih.gov/21643987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPA4,ENSG00000204086,Unsafe,7760808,"Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex.",1995,10.1128/mcb.15.6.3119,https://pubmed.ncbi.nlm.nih.gov/7760808/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPA4,ENSG00000204086,Unsafe,20545304,Functions of alternative replication protein A in initiation and elongation.,2010,10.1021/bi100380n,https://pubmed.ncbi.nlm.nih.gov/20545304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPA4,ENSG00000204086,Unsafe,10980409,Promoter structure and cell cycle dependent expression of the human methylpurine-DNA glycosylase gene.,2000,10.1016/s0921-8777(00)00036-7,https://pubmed.ncbi.nlm.nih.gov/10980409/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPA4,ENSG00000204086,Unsafe,19547738,Typhus and other rickettsioses: emerging infections in Germany.,2009,10.3238/arztebl.2009.0348,https://pubmed.ncbi.nlm.nih.gov/19547738/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,41966271,"RPAP3: Structural evolution, chaperone networks, and disease implications of a transcriptional Co-chaperone.",2026,10.1016/j.jbc.2026.111439,https://pubmed.ncbi.nlm.nih.gov/41966271/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,42837447,DNAAF19-RUVBL1/2 complex recruits multiple adaptors to promote dynein arm assembly.,2026,10.1073/pnas.2612755123,https://pubmed.ncbi.nlm.nih.gov/42837447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,42248294,Insights into the function and structure of the R2TP (RUVBL1-RUVBL2-RPAP3-PIH1D1) chaperone complex.,2026,10.1016/j.cstres.2026.100192,https://pubmed.ncbi.nlm.nih.gov/42248294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,42236530,Identification and validation of reference genes for quantitative real-time PCR in Corydalis saxicola under various abiotic stresses.,2026,10.1038/s41598-026-54993-0,https://pubmed.ncbi.nlm.nih.gov/42236530/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,42087217,Comprehensive molecular characterization identifies therapeutic vulnerabilities in ovarian clear cell carcinoma.,2026,10.1186/s13073-026-01663-5,https://pubmed.ncbi.nlm.nih.gov/42087217/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,41787535,The R2TP complex stabilises E7 to drive human papillomavirus-mediated pathogenesis in cellular models of cervical cancer.,2026,10.1186/s12985-026-03070-z,https://pubmed.ncbi.nlm.nih.gov/41787535/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,42020726,PIWIL1 activates the R2TP-TELO2-mTORC1 axis independently of piRNA to promote TOP mRNA translation in gastric cancer.,2026,10.1038/s41388-026-03791-z,https://pubmed.ncbi.nlm.nih.gov/42020726/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,37631136,Unveiling the Role of Sorghum RPAP3 in the Function of R2TP Complex: Insights into Protein Assembly in Plants.,2023,10.3390/plants12162925,https://pubmed.ncbi.nlm.nih.gov/37631136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,38159702,Identification and characterization of both cis- and trans-regulators mediating fenvalerate-induced expression of CYP6B7 in Helicoverpa armigera.,2024,10.1016/j.ijbiomac.2023.128995,https://pubmed.ncbi.nlm.nih.gov/38159702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,34376666,The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium.,2021,10.1038/s41467-021-24792-4,https://pubmed.ncbi.nlm.nih.gov/34376666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,35150569,The interaction between RPAP3 and TRBP reveals a possible involvement of the HSP90/R2TP chaperone complex in the regulation of miRNA activity.,2022,10.1093/nar/gkac086,https://pubmed.ncbi.nlm.nih.gov/35150569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,35129352,Unphosphorylated Form of the PAQosome Core Subunit RPAP3 Binds Ribosomal Preassembly Complexes to Modulate Ribosome Biogenesis.,2022,10.1021/acs.jproteome.1c00938,https://pubmed.ncbi.nlm.nih.gov/35129352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,29844425,The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones.,2018,10.1038/s41467-018-04431-1,https://pubmed.ncbi.nlm.nih.gov/29844425/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,32384603,RPAP3 C-Terminal Domain: A Conserved Domain for the Assembly of R2TP Co-Chaperone Complexes.,2020,10.3390/cells9051139,https://pubmed.ncbi.nlm.nih.gov/32384603/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,35078195,The Expression of the RUVBL1 Component of the R2TP Complex Correlates with Poor Prognosis in DLBCL.,2022,10.1159/000520723,https://pubmed.ncbi.nlm.nih.gov/35078195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,38192347,"The multi-faceted roles of R2TP complex span across regulation of gene expression, translation, and protein functional assembly.",2023,10.1007/s12551-023-01127-9,https://pubmed.ncbi.nlm.nih.gov/38192347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,33640610,Identification and characterization of R2TP in the development of oral squamous cell carcinoma.,2021,10.1016/j.bbrc.2021.02.074,https://pubmed.ncbi.nlm.nih.gov/33640610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,34233195,Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone.,2021,10.1016/j.celrep.2021.109317,https://pubmed.ncbi.nlm.nih.gov/34233195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,30033218,"Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex.",2018,10.1016/j.str.2018.06.002,https://pubmed.ncbi.nlm.nih.gov/30033218/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,29662061,RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex.,2018,10.1038/s41467-018-03942-1,https://pubmed.ncbi.nlm.nih.gov/29662061/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPAP3,ENSG00000005175,Unsafe,31018511,Identification of RUVBL1 and RUVBL2 as Novel Cellular Interactors of the Ebola Virus Nucleoprotein.,2019,10.3390/v11040372,https://pubmed.ncbi.nlm.nih.gov/31018511/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,41915430,Loss of RPGR disrupts motile cilia and causes primary ciliary dyskinesia by affecting F-actin dynamics.,2026,10.1172/jci193367,https://pubmed.ncbi.nlm.nih.gov/41915430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,41941273,Insights into retinal disease and non-tubulin glutamylation from a RPGR-TTLL5 complex structure.,2026,10.1083/jcb.202508020,https://pubmed.ncbi.nlm.nih.gov/41941273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,42573183,Defining a Novel RPGR Phenotype of Sector Retinitis Pigmentosa With Cone Dystrophy.,2026,10.1167/iovs.67.10.24,https://pubmed.ncbi.nlm.nih.gov/42573183/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,42609816,Genetic Insights Into Retinitis Pigmentosa: A De Novo &lt;i&gt;RPGR&lt;/i&gt; Mutation in an Iranian-Azeri Family.,2026,10.1155/crop/7640514,https://pubmed.ncbi.nlm.nih.gov/42609816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,42263801,Optimized AAV5-RPGR ORF15 Gene Therapy Rescues Photoreceptor Structure and Function in X-Linked Retinitis Pigmentosa Mouse Model.,2026,10.1016/j.ajo.2026.06.005,https://pubmed.ncbi.nlm.nih.gov/42263801/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,41323795,A human-specific &lt;i&gt;RPGR&lt;/i&gt; isoform and a clinically approved Rho/ROCK inhibitor ameliorate defects associated with RPGR dysfunction.,2025,10.1016/j.omtn.2025.102758,https://pubmed.ncbi.nlm.nih.gov/41323795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,42306097,Pathogenic mechanisms of &lt;i&gt;RPGR&lt;/i&gt; mutations in X-linked retinitis pigmentosa: integrating clinical pedigree and single-cell transcriptomics.,2026,10.3389/fgene.2026.1814462,https://pubmed.ncbi.nlm.nih.gov/42306097/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,41480687,Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review).,2026,10.3892/ijmm.2025.5723,https://pubmed.ncbi.nlm.nih.gov/41480687/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,42521440,Clinical and Genetic Landscape of RPGR -Associated Retinal Dystrophies in Portugal: Insights From the Nationwide IRD-PT Registry.,2026,10.1111/ceo.70149,https://pubmed.ncbi.nlm.nih.gov/42521440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,42576225,Efficacy and safety of AAV RPGR gene therapy in X-linked retinitis pigmentosa: a systematic review and meta-analysis.,2026,10.1186/s12967-026-08709-7,https://pubmed.ncbi.nlm.nih.gov/42576225/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,42652548,Functional Outcomes and Ocular Safety of Subretinal AAV-RPGR Gene Therapy for RPGR-Associated X-Linked Retinitis Pigmentosa: A Systematic Review and Meta-Analysis.,2026,10.3390/jcm15166144,https://pubmed.ncbi.nlm.nih.gov/42652548/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,42353874,First Exonic Cryptic Branchpoint Variant in an Inherited Retinal Degeneration Detected in an Irish &lt;i&gt;RPGR&lt;/i&gt; Pedigree with X-Linked Retinitis Pigmentosa.,2026,10.3390/genes17060715,https://pubmed.ncbi.nlm.nih.gov/42353874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,42460418,Pre-existing retinal inflammation exacerbates gene therapy-associated uveitis in more rapidly progressive retinal degeneration.,2026,10.1016/j.omta.2025.201652,https://pubmed.ncbi.nlm.nih.gov/42460418/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,41288322,RPGRORF15 Mutations Disrupt Lysosomal Lipid Metabolism in Retinal Pigment Epithelium Cells and Cause Retinitis Pigmentosa.,2025,10.1167/iovs.66.14.61,https://pubmed.ncbi.nlm.nih.gov/41288322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,40004550,Retinal Disease Variability in Female Carriers of &lt;i&gt;RPGR&lt;/i&gt; Variants Associated with Retinitis Pigmentosa: Clinical and Genetic Parameters.,2025,10.3390/genes16020221,https://pubmed.ncbi.nlm.nih.gov/40004550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,42389718,A novel chimeric RNA RPGR-EEF1A1 enhances autophagy by interaction with the small GTPase RAB37 in a GTP-dependent manner.,2026,10.1016/j.gendis.2026.102063,https://pubmed.ncbi.nlm.nih.gov/42389718/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,41481301,Phenotypic Manifestations in Female Carriers of RPGR ORF15 Variants Causing X-Linked Cone Dystrophy.,2026,10.1001/jamaophthalmol.2025.5492,https://pubmed.ncbi.nlm.nih.gov/41481301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,40597960,Analysis of choriocapillaris vascular density in patients with retinitis pigmentosa caused by RPGR gene mutations.,2025,10.1186/s12886-025-04163-z,https://pubmed.ncbi.nlm.nih.gov/40597960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,41773775,Efficacy and Safety of Gene Therapy for RPGR Gene-Associated X-Linked Retinitis Pigmentosa: A Systematic Review and Meta-Analysis.,2026,10.1167/tvst.15.3.5,https://pubmed.ncbi.nlm.nih.gov/41773775/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,42181665,Cystoid Macular Edema in Retinitis Pigmentosa: Pathophysiologic Insight Using Swept-Source OCT and Angiography.,2026,10.1016/j.xops.2026.101193,https://pubmed.ncbi.nlm.nih.gov/42181665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,42733973,Progress in gene therapy for RPGR-associated X-linked retinitis pigmentosa.,2026,10.1080/14712598.2026.2733200,https://pubmed.ncbi.nlm.nih.gov/42733973/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,42537978,"Efficacy, Safety, and Durability of Gene Therapy for Inherited Retinal Diseases in the Pediatric Population: A Scoping Review.",2026,10.1016/j.ajo.2026.07.039,https://pubmed.ncbi.nlm.nih.gov/42537978/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,42285469,Microperimetry as an Outcome Measure Improves Patient Eligibility and Efficacy Detection in RPGR Gene Therapy Trials.,2026,10.1016/j.ajo.2026.06.002,https://pubmed.ncbi.nlm.nih.gov/42285469/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,42064015,Patterns of X-Linked Retinitis Pigmentosa Genetic Testing in England and Implications for Service Provision.,2026,10.1016/j.xops.2026.101180,https://pubmed.ncbi.nlm.nih.gov/42064015/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,39941570,Pre-Clinical and Clinical Advances in Gene Therapy of X-Linked Retinitis Pigmentosa: Hope on the Horizon.,2025,10.3390/jcm14030898,https://pubmed.ncbi.nlm.nih.gov/39941570/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,40731809,Retinitis Pigmentosa: From Genetic Insights to Innovative Therapeutic Approaches-A Literature Review.,2025,10.3390/medicina61071179,https://pubmed.ncbi.nlm.nih.gov/40731809/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,42847595,Microperimetry Sensitivity Changes at the Functional Transition Zone and at the EZ Margins in X-Linked Retinitis Pigmentosa Treated With Gene Therapy.,2026,10.1167/tvst.15.10.10,https://pubmed.ncbi.nlm.nih.gov/42847595/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,42627399,Gene therapy clinical trials for inherited eye diseases: The pediatric perspective.,2026,10.1177/11206721261478166,https://pubmed.ncbi.nlm.nih.gov/42627399/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,40206241,A previously unreported &lt;i&gt;RPGR&lt;/i&gt; gene variant in a female patient with X-linked retinitis pigmentosa.,2025,10.5693/djo.02.2024.06.004,https://pubmed.ncbi.nlm.nih.gov/40206241/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,41457516,Age-Stratified Genetic Spectrum of Retinitis Pigmentosa in Korean Patients: Predominance of &lt;i&gt;RPGR&lt;/i&gt; Variants in Early-Onset Disease.,2026,10.3343/alm.2025.0146,https://pubmed.ncbi.nlm.nih.gov/41457516/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,41237986,Central Retinal Sensitivity Decline in RPGR-Related Retinal Phenotypes.,2026,10.1016/j.ajo.2025.11.002,https://pubmed.ncbi.nlm.nih.gov/41237986/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGR,ENSG00000156313,Unsafe,12140192,Species-specific subcellular localization of RPGR and RPGRIP isoforms: implications for the phenotypic variability of congenital retinopathies among species.,2002,10.1093/hmg/11.16.1899,https://pubmed.ncbi.nlm.nih.gov/12140192/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,41270749,"Connecting cilium, stress response, and proteostasis abnormalities inform variant and therapy assessment in RPGRIP1 retinal organoids.",2025,10.1016/j.stemcr.2025.102717,https://pubmed.ncbi.nlm.nih.gov/41270749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,41666299,DELETION INVOLVING EXON 18 OF RPGRIP1 IS a MAJOR CAUSE OF ACHROMATOPSIA.,2026,10.1097/iae.0000000000004778,https://pubmed.ncbi.nlm.nih.gov/41666299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,41551217,Genetic testing drives a decline in the occurrence of the canine PRA-related &lt;i&gt;RPGRIP1&lt;/i&gt; variant without an increase in inbreeding.,2026,10.1016/j.vas.2025.100555,https://pubmed.ncbi.nlm.nih.gov/41551217/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,40737315,"Whole exome sequencing reveals pathogenic variants in CNGA3, CACNA1F, and RPGRIP1 in consanguineous Pakistani families with diverse retinal phenotypes.",2025,10.1371/journal.pone.0327176,https://pubmed.ncbi.nlm.nih.gov/40737315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,41581050,A digenic contribution of RPGRIP1 and SLC4A4 to juvenile-onset open-angle glaucoma phenotype with concomitant corneal dystrophy.,2026,10.4103/ijo.ijo_2810_24,https://pubmed.ncbi.nlm.nih.gov/41581050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,39428496,Delayed-onset cord1 progressive retinal atrophy in English Springer Spaniels genetically affected with the RPGRIP1 variant.,2026,10.1111/vop.13290,https://pubmed.ncbi.nlm.nih.gov/39428496/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,41904215,A novel phenotype-guided genome analysis pipeline for variant discovery.,2026,10.1038/s41525-026-00557-0,https://pubmed.ncbi.nlm.nih.gov/41904215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,39669618,A homozygous structural variant of &lt;i&gt;RPGRIP1&lt;/i&gt; is frequently associated with achromatopsia in Japanese patients with IRD.,2024,10.1016/j.gimo.2024.101843,https://pubmed.ncbi.nlm.nih.gov/39669618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,38468396,Autozygome-guided exome-first study in a consanguineous cohort with early-onset retinal disease uncovers an isolated RIMS2 phenotype and a retina-enriched RIMS2 isoform.,2024,10.1111/cge.14517,https://pubmed.ncbi.nlm.nih.gov/38468396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,39388365,Astrogliosis and neuroinflammation underlie scoliosis upon cilia dysfunction.,2024,10.7554/elife.96831,https://pubmed.ncbi.nlm.nih.gov/39388365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,36951959,Natural disease history of a canine model of oligogenic RPGRIP1-cone-rod dystrophy establishes variable effects of previously and newly mapped modifier loci.,2023,10.1093/hmg/ddad046,https://pubmed.ncbi.nlm.nih.gov/36951959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,37650070,Molecular characterization of MAP9 in the photoreceptor sensory cilia as a modifier in canine RPGRIP1-associated cone-rod dystrophy.,2023,10.3389/fncel.2023.1226603,https://pubmed.ncbi.nlm.nih.gov/37650070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,41201214,Novel Heterozygous Variant in &lt;i&gt;RP1L1&lt;/i&gt; Gene With Retinitis Pigmentosa Phenotype: A Case Report.,2026,10.3928/23258160-20251020-01,https://pubmed.ncbi.nlm.nih.gov/41201214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,37761981,The Structural Abnormalities Are Deeply Involved in the Cause of &lt;i&gt;RPGRIP1&lt;/i&gt;-Related Retinal Dystrophy in Japanese Patients.,2023,10.3390/ijms241813678,https://pubmed.ncbi.nlm.nih.gov/37761981/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,38816995,Whole genome sequencing identifies elusive variants in genetically unsolved Italian inherited retinal disease patients.,2024,10.1016/j.xhgg.2024.100314,https://pubmed.ncbi.nlm.nih.gov/38816995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,36762997,&lt;i&gt;RPGRIP1&lt;/i&gt;-related retinal disease presenting as isolated cone dysfunction.,2023,10.1080/13816810.2023.2175224,https://pubmed.ncbi.nlm.nih.gov/36762997/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,38662103,Clinical and genetic studies for a cohort of patients with Leber congenital amaurosis.,2024,10.1007/s00417-024-06450-9,https://pubmed.ncbi.nlm.nih.gov/38662103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,40232708,Clinical Spectrum and Molecular Characteristics of Inherited Ocular Diseases in a Cohort of Pediatric Patients With Infantile Nystagmus Syndrome.,2025,10.1167/iovs.66.4.39,https://pubmed.ncbi.nlm.nih.gov/40232708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,40763962,[Analysis of clinical manifestations and genetic variants among 11 Chinese pedigrees affected with Leber congenital amaurosis].,2025,10.3760/cma.j.cn511374-20241218-00664,https://pubmed.ncbi.nlm.nih.gov/40763962/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,34722527,"Retinal Degeneration Associated With RPGRIP1: A Review of Natural History, Mutation Spectrum, and Genotype-Phenotype Correlation in 228 Patients.",2021,10.3389/fcell.2021.746781,https://pubmed.ncbi.nlm.nih.gov/34722527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,39728598,Leber congenital amaurosis: A clinical and genetic study from a tertiary eye care center.,2025,10.4103/ijo.ijo_545_24,https://pubmed.ncbi.nlm.nih.gov/39728598/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,39271608,Ocular genetics in the Japanese population.,2024,10.1007/s10384-024-01109-8,https://pubmed.ncbi.nlm.nih.gov/39271608/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,34209942,Gypenosides Alleviate Cone Cell Death in a Zebrafish Model of Retinitis Pigmentosa.,2021,10.3390/antiox10071050,https://pubmed.ncbi.nlm.nih.gov/34209942/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,25414380,Leber congenital amaurosis caused by mutations in RPGRIP1.,2014,10.1101/cshperspect.a017384,https://pubmed.ncbi.nlm.nih.gov/25414380/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,34523677,Methylome-wide association study of early life stressors and adult mental health.,2022,10.1093/hmg/ddab274,https://pubmed.ncbi.nlm.nih.gov/34523677/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,33308271,Novel gene variants in Polish patients with Leber congenital amaurosis (LCA).,2020,10.1186/s13023-020-01634-y,https://pubmed.ncbi.nlm.nih.gov/33308271/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,28966547,Diagnostic application of clinical exome sequencing in Leber congenital amaurosis.,2017,,https://pubmed.ncbi.nlm.nih.gov/28966547/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,25775262,Homozygosity mapping and targeted sanger sequencing reveal genetic defects underlying inherited retinal disease in families from pakistan.,2015,10.1371/journal.pone.0119806,https://pubmed.ncbi.nlm.nih.gov/25775262/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,20384479,Replacement gene therapy with a human RPGRIP1 sequence slows photoreceptor degeneration in a murine model of Leber congenital amaurosis.,2010,10.1089/hum.2009.218,https://pubmed.ncbi.nlm.nih.gov/20384479/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,22807295,Exclusion of RPGRIP1 ins44 from primary causal association with early-onset cone-rod dystrophy in dogs.,2012,10.1167/iovs.12-10178,https://pubmed.ncbi.nlm.nih.gov/22807295/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,15800011,Limited proteolysis differentially modulates the stability and subcellular localization of domains of RPGRIP1 that are distinctly affected by mutations in Leber's congenital amaurosis.,2005,10.1093/hmg/ddi143,https://pubmed.ncbi.nlm.nih.gov/15800011/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,26512990,Predose and Postdose Blood Gene Expression Profiles Identify the Individuals Susceptible to Acetaminophen-Induced Liver Injury in Rats.,2015,10.1371/journal.pone.0141750,https://pubmed.ncbi.nlm.nih.gov/26512990/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,19223988,"The RPGRIP1-deficient dog, a promising canine model for gene therapy.",2009,,https://pubmed.ncbi.nlm.nih.gov/19223988/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,25692141,Cone dystrophy in patient with homozygous RP1L1 mutation.,2015,10.1155/2015/545243,https://pubmed.ncbi.nlm.nih.gov/25692141/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,19840725,Which Leber congenital amaurosis patients are eligible for gene therapy trials?,2009,10.1016/j.jaapos.2009.08.006,https://pubmed.ncbi.nlm.nih.gov/19840725/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,12140192,Species-specific subcellular localization of RPGR and RPGRIP isoforms: implications for the phenotypic variability of congenital retinopathies among species.,2002,10.1093/hmg/11.16.1899,https://pubmed.ncbi.nlm.nih.gov/12140192/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,10958647,Identification of a novel protein interacting with RPGR.,2000,10.1093/hmg/9.14.2085,https://pubmed.ncbi.nlm.nih.gov/10958647/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPGRIP1,ENSG00000092200,Unsafe,10958648,The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors.,2000,10.1093/hmg/9.14.2095,https://pubmed.ncbi.nlm.nih.gov/10958648/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL10L,ENSG00000165496,Unsafe,39201790,Comprehensive Analysis of Methylome and Transcriptome to Identify Potential Genes Regulating Porcine Testis Development.,2024,10.3390/ijms25169105,https://pubmed.ncbi.nlm.nih.gov/39201790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL10L,ENSG00000165496,Unsafe,39380204,SMARTdb: An Integrated Database for Exploring Single-cell Multi-omics Data of Reproductive Medicine.,2024,10.1093/gpbjnl/qzae005,https://pubmed.ncbi.nlm.nih.gov/39380204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL10L,ENSG00000165496,Unsafe,38304813,Transcriptomics analysis reveals distinct mechanism of breast cancer stem cells regulation in mammospheres from MCF-7 and T47D cells.,2024,10.1016/j.heliyon.2024.e24356,https://pubmed.ncbi.nlm.nih.gov/38304813/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL10L,ENSG00000165496,Unsafe,28502657,RPL10L Is Required for Male Meiotic Division by Compensating for RPL10 during Meiotic Sex Chromosome Inactivation in Mice.,2017,10.1016/j.cub.2017.04.017,https://pubmed.ncbi.nlm.nih.gov/28502657/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL10L,ENSG00000165496,Unsafe,34675667,Development and Validation of a Prognostic Model of RNA-Binding Proteins in Colon Adenocarcinoma: A Study Based on TCGA and GEO Databases.,2021,10.2147/cmar.s330434,https://pubmed.ncbi.nlm.nih.gov/34675667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL10L,ENSG00000165496,Unsafe,30317246,Comprehensive Bioinformatic Analysis Genes Associated to the Prognosis of Liposarcoma.,2018,10.12659/msm.913043,https://pubmed.ncbi.nlm.nih.gov/30317246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL10L,ENSG00000165496,Unsafe,24860015,Ribosome-omics of the human ribosome.,2014,10.1261/rna.043653.113,https://pubmed.ncbi.nlm.nih.gov/24860015/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL10L,ENSG00000165496,Unsafe,19333399,Spermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers.,2009,10.1371/journal.pone.0005064,https://pubmed.ncbi.nlm.nih.gov/19333399/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL10L,ENSG00000165496,Unsafe,12490704,Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes.,2002,10.1093/nar/gkf696,https://pubmed.ncbi.nlm.nih.gov/12490704/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL10L,ENSG00000165496,Unsafe,27220462,Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference.,2016,10.3892/or.2016.4821,https://pubmed.ncbi.nlm.nih.gov/27220462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,40421595,Functional Characterization and Heterogeneity Analysis of Ribosomal Proteins in Mouse Preimplantation Embryos.,2025,10.1096/fj.202500574rr,https://pubmed.ncbi.nlm.nih.gov/40421595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,39041433,Ribosomal protein RPL39L is an efficiency factor in the cotranslational folding of a subset of proteins with alpha helical domains.,2024,10.1093/nar/gkae630,https://pubmed.ncbi.nlm.nih.gov/39041433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,40153586,Exploring the Mechanisms of Testicular Aging: Advances in Biomarker Research.,2025,10.14336/ad.2025.0070,https://pubmed.ncbi.nlm.nih.gov/40153586/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,42729953,Identification of ultrasound-associated gene candidates in myeloid cells and construction of a prognostic risk model for acute myeloid leukemia.,2026,10.7717/peerj.21661,https://pubmed.ncbi.nlm.nih.gov/42729953/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,41737832,Cuproptosis-related gene signatures define immune subtypes and predict prognosis in gastric cancer.,2026,10.3389/fmolb.2026.1746613,https://pubmed.ncbi.nlm.nih.gov/41737832/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,39380204,SMARTdb: An Integrated Database for Exploring Single-cell Multi-omics Data of Reproductive Medicine.,2024,10.1093/gpbjnl/qzae005,https://pubmed.ncbi.nlm.nih.gov/39380204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,41026376,Integrative multi-omics analysis identifies AEBP1 and EFEMP2 as key regulators of immune heterogeneity and therapeutic response in glioblastoma.,2025,10.1007/s12672-025-03500-4,https://pubmed.ncbi.nlm.nih.gov/41026376/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,40341308,DNA damage repair-related methylated genes RRM2 and GAPDH are prognostic biomarkers associated with immunotherapy for lung adenocarcinoma.,2025,10.1590/1678-4685-gmb-2024-0138,https://pubmed.ncbi.nlm.nih.gov/40341308/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,34825148,Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis.,2021,10.1016/j.isci.2021.103396,https://pubmed.ncbi.nlm.nih.gov/34825148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,41206371,Regulation of ribosomal gene expression and senescence by a PML-mTOR-RONIN nuclear complex in triple-negative breast cancer.,2025,10.1038/s41388-025-03623-6,https://pubmed.ncbi.nlm.nih.gov/41206371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,36733371,LASSO-based screening for potential prognostic biomarkers associated with glioblastoma.,2022,10.3389/fonc.2022.1057383,https://pubmed.ncbi.nlm.nih.gov/36733371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,39940786,"A Computational Recognition Analysis of Promising Prognostic Biomarkers in Breast, Colon and Lung Cancer Patients.",2025,10.3390/ijms26031017,https://pubmed.ncbi.nlm.nih.gov/39940786/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,42369705,[The Role of Cuproptosis Related Key Genes in Ovarian Cancer and the Construction of a Prognostic Model].,2026,10.12182/20260560504,https://pubmed.ncbi.nlm.nih.gov/42369705/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,37091794,Bioinformatics analysis based on crucial genes of endothelial cells in rheumatoid.,2023,10.3389/fgene.2023.1143644,https://pubmed.ncbi.nlm.nih.gov/37091794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,36517592,A male germ-cell-specific ribosome controls male fertility.,2022,10.1038/s41586-022-05508-0,https://pubmed.ncbi.nlm.nih.gov/36517592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,34428590,Deletion of ribosomal paralogs Rpl39 and Rpl39l compromises cell proliferation via protein synthesis and mitochondrial activity.,2021,10.1016/j.biocel.2021.106070,https://pubmed.ncbi.nlm.nih.gov/34428590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,35741659,Exploration of the Common Gene Characteristics and Molecular Mechanism of Parkinson's Disease and Crohn's Disease from Transcriptome Data.,2022,10.3390/brainsci12060774,https://pubmed.ncbi.nlm.nih.gov/35741659/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,31423161,A novel CpG island methylation panel predicts survival in lung adenocarcinomas.,2019,10.3892/ol.2019.10431,https://pubmed.ncbi.nlm.nih.gov/31423161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,34808269,Identification of Alzheimer associated differentially expressed gene through microarray data and transfer learning-based image analysis.,2022,10.1016/j.neulet.2021.136357,https://pubmed.ncbi.nlm.nih.gov/34808269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,24452241,RPL39L is an example of a recently evolved ribosomal protein paralog that shows highly specific tissue expression patterns and is upregulated in ESCs and HCC tumors.,2014,10.4161/rna.27427,https://pubmed.ncbi.nlm.nih.gov/24452241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,33015072,Development and Validation of a Novel DNA Methylation-Driven Gene Based Molecular Classification and Predictive Model for Overall Survival and Immunotherapy Response in Patients With Glioblastoma: A Multiomic Analysis.,2020,10.3389/fcell.2020.576996,https://pubmed.ncbi.nlm.nih.gov/33015072/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,19333399,Spermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers.,2009,10.1371/journal.pone.0005064,https://pubmed.ncbi.nlm.nih.gov/19333399/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPL39L,ENSG00000163923,Unsafe,12490704,Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes.,2002,10.1093/nar/gkf696,https://pubmed.ncbi.nlm.nih.gov/12490704/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP14,ENSG00000163684,Unsafe,42277007,TRNAU1AP and PRPF39 establish integrated control over processing of most abundant human non-coding RNAs.,2026,10.1038/s41467-026-74036-6,https://pubmed.ncbi.nlm.nih.gov/42277007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP14,ENSG00000163684,Unsafe,40517827,Ribonuclease P/MRP subunit RPP40 coordinates the transcription of pre-rRNA and ribosomal protein genes to promote Hepatocellular carcinoma malignancy.,2025,10.1016/j.gene.2025.149622,https://pubmed.ncbi.nlm.nih.gov/40517827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP14,ENSG00000163684,Unsafe,40943169,Genome-Wide Association Studies in Japanese Quails of the F&lt;sub&gt;2&lt;/sub&gt; Resource Population Elucidate Molecular Markers and Candidate Genes for Body Weight Parameters.,2025,10.3390/ijms26178243,https://pubmed.ncbi.nlm.nih.gov/40943169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP14,ENSG00000163684,Unsafe,37831743,Human RNase P exhibits and controls distinct ribonucleolytic activities required for ordered maturation of tRNA.,2023,10.1073/pnas.2307185120,https://pubmed.ncbi.nlm.nih.gov/37831743/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP14,ENSG00000163684,Unsafe,35685372,Deregulated molecules and pathways in the predisposition and dissemination of breast cancer cells to bone.,2022,10.1016/j.csbj.2022.05.051,https://pubmed.ncbi.nlm.nih.gov/35685372/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP14,ENSG00000163684,Unsafe,32295841,Learning-induced mRNA alterations in olfactory bulb mitral cells in neonatal rats.,2020,10.1101/lm.051177.119,https://pubmed.ncbi.nlm.nih.gov/32295841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP14,ENSG00000163684,Unsafe,28432356,"A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks.",2017,10.1038/s41598-017-01185-6,https://pubmed.ncbi.nlm.nih.gov/28432356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP14,ENSG00000163684,Unsafe,24534757,PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6.,2015,10.1136/annrheumdis-2013-204909,https://pubmed.ncbi.nlm.nih.gov/24534757/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP14,ENSG00000163684,Unsafe,17898086,An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing.,2008,10.1096/fj.07-8986,https://pubmed.ncbi.nlm.nih.gov/17898086/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP14,ENSG00000163684,Unsafe,10024167,"Rpp14 and Rpp29, two protein subunits of human ribonuclease P.",1999,10.1017/s135583829800185x,https://pubmed.ncbi.nlm.nih.gov/10024167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP14,ENSG00000163684,Unsafe,11929972,"A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity.",2002,10.1073/pnas.072083699,https://pubmed.ncbi.nlm.nih.gov/11929972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP14,ENSG00000163684,Unsafe,10444065,Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P.,1999,10.1083/jcb.146.3.559,https://pubmed.ncbi.nlm.nih.gov/10444065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP14,ENSG00000163684,Unsafe,19028688,Mitochondrial fatty acid synthesis type II: more than just fatty acids.,2009,10.1074/jbc.r800068200,https://pubmed.ncbi.nlm.nih.gov/19028688/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP14,ENSG00000163684,Unsafe,16723659,Differential association of protein subunits with the human RNase MRP and RNase P complexes.,2006,10.1261/rna.2293906,https://pubmed.ncbi.nlm.nih.gov/16723659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP14,ENSG00000163684,Unsafe,12003489,"Purification and characterization of Rpp25, an RNA-binding protein subunit of human ribonuclease P.",2002,10.1017/s1355838202027954,https://pubmed.ncbi.nlm.nih.gov/12003489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP14,ENSG00000163684,Unsafe,15096576,Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex.,2004,10.1093/nar/gkh539,https://pubmed.ncbi.nlm.nih.gov/15096576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP14,ENSG00000163684,Unsafe,11158571,Protein-protein interactions with subunits of human nuclear RNase P.,2001,10.1073/pnas.98.3.920,https://pubmed.ncbi.nlm.nih.gov/11158571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,42477774,Transcriptomic profiling of pediatric asthma by diseases state and severity.,2026,10.1186/s12931-026-03805-0,https://pubmed.ncbi.nlm.nih.gov/42477774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,40517827,Ribonuclease P/MRP subunit RPP40 coordinates the transcription of pre-rRNA and ribosomal protein genes to promote Hepatocellular carcinoma malignancy.,2025,10.1016/j.gene.2025.149622,https://pubmed.ncbi.nlm.nih.gov/40517827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,38116482,Genetic Switches between Cancer and Emphysema Resolution of Cigarette-Smoke Induced Inflammation.,2019,,https://pubmed.ncbi.nlm.nih.gov/38116482/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,32330594,Pilot study of combined aerobic and resistance exercise on fatigue for patients with head and neck cancer: Inflammatory and epigenetic changes.,2020,10.1016/j.bbi.2020.04.044,https://pubmed.ncbi.nlm.nih.gov/32330594/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,29372908,Crystal structures of the archaeal RNase P protein Rpp38 in complex with RNA fragments containing a K-turn motif.,2018,10.1107/s2053230x17018039,https://pubmed.ncbi.nlm.nih.gov/29372908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,28432356,"A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks.",2017,10.1038/s41598-017-01185-6,https://pubmed.ncbi.nlm.nih.gov/28432356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,12907726,Alterations in the intracellular level of a protein subunit of human RNase P affect processing of tRNA precursors.,2003,10.1093/nar/gkg691,https://pubmed.ncbi.nlm.nih.gov/12907726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,16131590,Regulated expression of functional external guide sequences in mammalian cells using a U6 RNA polymerase III promoter.,2005,10.1261/rna.2140505,https://pubmed.ncbi.nlm.nih.gov/16131590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,12552092,Coordinate inhibition of expression of several genes for protein subunits of human nuclear RNase P.,2003,10.1073/pnas.0337661100,https://pubmed.ncbi.nlm.nih.gov/12552092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,10444065,Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P.,1999,10.1083/jcb.146.3.559,https://pubmed.ncbi.nlm.nih.gov/10444065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,12176814,Differences in autoantibody response to Th/To between systemic sclerosis and other autoimmune diseases.,2002,10.1136/ard.61.9.842,https://pubmed.ncbi.nlm.nih.gov/12176814/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,10199568,RNA-protein interactions in the human RNase MRP ribonucleoprotein complex.,1999,10.1017/s1355838299982079,https://pubmed.ncbi.nlm.nih.gov/10199568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,9630247,Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P.,1998,,https://pubmed.ncbi.nlm.nih.gov/9630247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,16723659,Differential association of protein subunits with the human RNase MRP and RNase P complexes.,2006,10.1261/rna.2293906,https://pubmed.ncbi.nlm.nih.gov/16723659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,11694598,Basic domains target protein subunits of the RNase MRP complex to the nucleolus independently of complex association.,2001,10.1091/mbc.12.11.3680,https://pubmed.ncbi.nlm.nih.gov/11694598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,15351636,"Inhibition of the expression of the human RNase P protein subunits Rpp21, Rpp25, Rpp29 by external guide sequences (EGSs) and siRNA.",2004,10.1016/j.jmb.2004.06.006,https://pubmed.ncbi.nlm.nih.gov/15351636/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,10024167,"Rpp14 and Rpp29, two protein subunits of human ribonuclease P.",1999,10.1017/s135583829800185x,https://pubmed.ncbi.nlm.nih.gov/10024167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,12003489,"Purification and characterization of Rpp25, an RNA-binding protein subunit of human ribonuclease P.",2002,10.1017/s1355838202027954,https://pubmed.ncbi.nlm.nih.gov/12003489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,9037013,Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P.,1997,10.1073/pnas.94.4.1101,https://pubmed.ncbi.nlm.nih.gov/9037013/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,15096576,Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex.,2004,10.1093/nar/gkh539,https://pubmed.ncbi.nlm.nih.gov/15096576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,15382680,Analyzing the H19- and T65-epitopes in 38 kd phosphorylated protein of Marek's disease viruses and comparing chicken immunological reactions to viruses point-mutated in the epitopes.,2004,10.1360/02yc0173,https://pubmed.ncbi.nlm.nih.gov/15382680/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPP38,ENSG00000152464,Unsafe,10696440,Construction and characterization of a H19 epitope point mutant of MDV CVI988/Rispens strain.,1999,,https://pubmed.ncbi.nlm.nih.gov/10696440/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,42393735,Extracellular vesicle-mediated GALNT1/RPRD1A glycosylation axis drives immune escape and peritoneal metastasis in gastric cancer.,2026,10.1186/s13046-026-03759-7,https://pubmed.ncbi.nlm.nih.gov/42393735/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,42171939,RPRD1A drives lenvatinib resistance in hepatocellular carcinoma via the ITGA5-FAK signaling axis.,2026,10.1186/s43556-026-00459-8,https://pubmed.ncbi.nlm.nih.gov/42171939/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,41885969,Development and validation of a highly accurate multigene gene expression biomarker to predict chemotherapy response in primary triple-negative breast cancer.,2026,10.1007/s10549-026-07950-4,https://pubmed.ncbi.nlm.nih.gov/41885969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,40346476,Multi-omics integrated analysis reveals the molecular mechanism of tail fat deposition differences in sheep with different tail types.,2025,10.1186/s12864-025-11658-y,https://pubmed.ncbi.nlm.nih.gov/40346476/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,38714724,Circ-0075305 hinders gastric cancer stem cells by indirectly disrupting TCF4-β-catenin complex and downregulation of SOX9.,2024,10.1038/s42003-024-06213-6,https://pubmed.ncbi.nlm.nih.gov/38714724/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,41751104,"Kinglet in the Poultry Court of Russia: Whole-Genome Insights into Ancestry, Genetic Variability, Selection Footprints and Candidate Genes in a Unique Local Chicken Breed Relative to Other Bantam/Dwarf Breeds.",2026,10.3390/ani16040642,https://pubmed.ncbi.nlm.nih.gov/41751104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,33239754,"Current understanding of CREPT and p15RS, carboxy-terminal domain (CTD)-interacting proteins, in human cancers.",2021,10.1038/s41388-020-01544-0,https://pubmed.ncbi.nlm.nih.gov/33239754/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,37985391,Autoantibody repertoire profiling in tissue and blood identifies colorectal cancer-specific biomarkers.,2024,10.1111/cas.16011,https://pubmed.ncbi.nlm.nih.gov/37985391/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,34921137,RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding.,2021,10.1038/s41419-021-04447-4,https://pubmed.ncbi.nlm.nih.gov/34921137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,28695988,CREPT and p15RS regulate cell proliferation and cycling in chicken DF-1 cells through the Wnt/β-catenin pathway.,2018,10.1002/jcb.26277,https://pubmed.ncbi.nlm.nih.gov/28695988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,35863089,Exosomes from bone marrow mesenchymal stem cells decrease chemosensitivity of acute myeloid leukemia cells via delivering miR-10a.,2022,10.1016/j.bbrc.2022.07.017,https://pubmed.ncbi.nlm.nih.gov/35863089/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,30809286,MiR-454-3p-Mediated Wnt/β-catenin Signaling Antagonists Suppression Promotes Breast Cancer Metastasis.,2019,10.7150/thno.29055,https://pubmed.ncbi.nlm.nih.gov/30809286/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,25697359,p15RS/RPRD1A (p15INK4b-related sequence/regulation of nuclear pre-mRNA domain-containing protein 1A) interacts with HDAC2 in inhibition of the Wnt/β-catenin signaling pathway.,2015,10.1074/jbc.m114.620872,https://pubmed.ncbi.nlm.nih.gov/25697359/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,29618509,Dimerization of p15RS mediated by a leucine zipper-like motif is critical for its inhibitory role on Wnt signaling.,2018,10.1074/jbc.ra118.001969,https://pubmed.ncbi.nlm.nih.gov/29618509/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,32175184,A preliminary study of the effect of a high-salt diet on transcriptome dynamics in rat hypothalamic forebrain and brainstem cardiovascular control centers.,2020,10.7717/peerj.8528,https://pubmed.ncbi.nlm.nih.gov/32175184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,22580456,Cellular and molecular evidence for malignancy-inhibitory functions of p15RS.,2012,10.4161/cc.20400,https://pubmed.ncbi.nlm.nih.gov/22580456/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,31054975,Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins.,2019,10.1016/j.molcel.2019.04.008,https://pubmed.ncbi.nlm.nih.gov/31054975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,20739273,p15RS attenuates Wnt/{beta}-catenin signaling by disrupting {beta}-catenin·TCF4 Interaction.,2010,10.1074/jbc.m110.148791,https://pubmed.ncbi.nlm.nih.gov/20739273/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,24997600,RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.,2014,10.1038/nsmb.2853,https://pubmed.ncbi.nlm.nih.gov/24997600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RPRD1A,ENSG00000141425,Unsafe,22231121,Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B.,2011,10.4161/trns.2.5.17803,https://pubmed.ncbi.nlm.nih.gov/22231121/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH10B,ENSG00000155026,Unsafe,40564862,Neurodevelopment Genes Encoding Olduvai Domains Link Myalgic Encephalomyelitis to Neuropsychiatric Disorders.,2025,10.3390/diagnostics15121542,https://pubmed.ncbi.nlm.nih.gov/40564862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH10B,ENSG00000155026,Unsafe,34871179,Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM.,2021,10.1073/pnas.2021180118,https://pubmed.ncbi.nlm.nih.gov/34871179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH10B,ENSG00000155026,Unsafe,31057555,Analysis of Global Transcriptome Change in Mouse Embryonic Fibroblasts After dsDNA and dsRNA Viral Mimic Stimulation.,2019,10.3389/fimmu.2019.00836,https://pubmed.ncbi.nlm.nih.gov/31057555/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RSPH10B2,ENSG00000169402,Unsafe,42420839,Consensus-based detection of aetiologic copy number variants for syndromic orofacial clefts utilising whole exome sequencing of case parent trios.,2026,10.1186/s12863-026-01466-y,https://pubmed.ncbi.nlm.nih.gov/42420839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,42649225,RTEL1 mutation modifies dyskeratosis congenita caused by a telomerase RNA template mutation.,2026,10.1038/s41467-026-76650-w,https://pubmed.ncbi.nlm.nih.gov/42649225/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,42497987,Human length telomeres restrict the regenerative potential of hematopoietic stem cells in mice.,2026,10.1016/j.jbc.2026.113364,https://pubmed.ncbi.nlm.nih.gov/42497987/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,42619260,The pleiotropic landscape of rare variant associations with multiple cancers in large biobanks.,2026,10.1016/j.xhgg.2026.100662,https://pubmed.ncbi.nlm.nih.gov/42619260/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,42086202,The DNA helicase RTEL1 is involved in the repair of replicative DNA damage independently of the alternative end joining and the DNA-protein cross-link repair pathways in Arabidopsis.,2026,10.1111/tpj.70903,https://pubmed.ncbi.nlm.nih.gov/42086202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,41424170,Subclinical Telomere Biology Disorder in Cancer Patients Heterozygous for the RTEL1 R1264H Founder Variant.,2026,10.1002/ajmga.70032,https://pubmed.ncbi.nlm.nih.gov/41424170/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,42510961,Next-Generation Sequencing in Pulmonary Fibrosis: Translational Promise and Current Clinical Limitations.,2026,10.3390/cimb48070721,https://pubmed.ncbi.nlm.nih.gov/42510961/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,39156922,Discovery of a Novel Shared Variant Among RTEL1 Gene and RTEL1-TNFRSF6B lncRNA at Chromosome 20q13.33 in Familial Progressive Myoclonus Epilepsy.,2024,10.1155/2024/7518528,https://pubmed.ncbi.nlm.nih.gov/39156922/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,40087886,Rapid dynamics allow the low-abundance RTEL1 helicase to promote telomere replication.,2025,10.1093/nar/gkaf177,https://pubmed.ncbi.nlm.nih.gov/40087886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,42736390,Genomic and computational analysis of variants in telomere regulatory genes in subjects with bone marrow failure.,2026,10.1038/s41431-026-02233-4,https://pubmed.ncbi.nlm.nih.gov/42736390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,40530700,Separation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1.,2025,10.1093/nar/gkaf507,https://pubmed.ncbi.nlm.nih.gov/40530700/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,41204139,A novel RTEL1 nonsense variant in a case of familial pulmonary fibrosis: clinical description and genetic implications.,2025,10.1186/s12890-025-03976-4,https://pubmed.ncbi.nlm.nih.gov/41204139/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,39724284,RTEL1 is upregulated in gastric cancer and promotes tumor growth.,2024,10.1007/s00432-024-06062-0,https://pubmed.ncbi.nlm.nih.gov/39724284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,40424856,Whole exome sequencing identified three novel mutations of RTEL1 in Chinese patients with idiopathic pulmonary fibrosis.,2025,10.1016/j.bbadis.2025.167924,https://pubmed.ncbi.nlm.nih.gov/40424856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,38532312,High expression of RTEL1 predicates worse progression in gliomas and promotes tumorigenesis through JNK/ELK1 cascade.,2024,10.1186/s12885-024-12134-8,https://pubmed.ncbi.nlm.nih.gov/38532312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,39240887,A comprehensive in silico investigation into the pathogenic SNPs in the RTEL1 gene and their biological consequences.,2024,10.1371/journal.pone.0309713,https://pubmed.ncbi.nlm.nih.gov/39240887/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,42316340,Telomere biology disorders associated with childhood interstitial lung disease.,2026,10.3345/cep.2026.00290,https://pubmed.ncbi.nlm.nih.gov/42316340/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,42612102,Liver-associated findings and outcomes in a telomere biology disorders clinic.,2026,10.1097/hc9.0000000000001021,https://pubmed.ncbi.nlm.nih.gov/42612102/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,36253342,Regulator of telomere elongation helicase 1 gene and its association with malignancy.,2023,10.1002/cnr2.1735,https://pubmed.ncbi.nlm.nih.gov/36253342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,38132118,Human RTEL1 Interacts with KPNB1 (Importin β) and NUP153 and Connects Nuclear Import to Nuclear Envelope Stability in S-Phase.,2023,10.3390/cells12242798,https://pubmed.ncbi.nlm.nih.gov/38132118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,37988793,RTEL1 is upregulated in colorectal cancer and promotes tumor progression.,2023,10.1016/j.prp.2023.154958,https://pubmed.ncbi.nlm.nih.gov/37988793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,39279436,Germline RTEL1 Variants in Telomere Biology Disorders.,2025,10.1002/ajmg.a.63882,https://pubmed.ncbi.nlm.nih.gov/39279436/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,40294351,Identification and Validation of Gastric Adenocarcinoma Prognosis Features Based on Neutrophil-Related Genes.,2025,10.1200/po-24-00590,https://pubmed.ncbi.nlm.nih.gov/40294351/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,41142505,Bone Marrow Failure Associated With Short Telomeres and Digenic Variants of Uncertain Significance in Telomere Biology Genes.,2025,10.1155/crig/2075063,https://pubmed.ncbi.nlm.nih.gov/41142505/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,38001404,RTEL1 gene polymorphisms and neuroblastoma risk in Chinese children.,2023,10.1186/s12885-023-11642-3,https://pubmed.ncbi.nlm.nih.gov/38001404/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,37328761,Ultra-rare RTEL1 gene variants associate with acute severity of COVID-19 and evolution to pulmonary fibrosis as a specific long COVID disorder.,2023,10.1186/s12931-023-02458-7,https://pubmed.ncbi.nlm.nih.gov/37328761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,38552771,"Environmental copper exposure, placental cuproptosis, and miscarriage.",2024,10.1016/j.envpol.2024.123847,https://pubmed.ncbi.nlm.nih.gov/38552771/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,38617957,"Exploration of the potential causative genes for inflammatory bowel disease: Transcriptome-wide association analysis, Mendelian randomization analysis and Bayesian colocalisation.",2024,10.1016/j.heliyon.2024.e28944,https://pubmed.ncbi.nlm.nih.gov/38617957/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,37872177,Telomouse-a mouse model with human-length telomeres generated by a single amino acid change in RTEL1.,2023,10.1038/s41467-023-42534-6,https://pubmed.ncbi.nlm.nih.gov/37872177/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,37746290,"Pertinence of glioma and single nucleotide polymorphism of TERT, CCDC26, CDKN2A/B and RTEL1 genes in glioma: a meta-analysis.",2023,10.3389/fonc.2023.1180099,https://pubmed.ncbi.nlm.nih.gov/37746290/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,36090019,Compound heterozygous mutation of RTEL1 in interstitial lung disease complicated with pneumothorax and emphysema: A case report and literature review.,2022,10.1002/rcr2.1032,https://pubmed.ncbi.nlm.nih.gov/36090019/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,39911301,Adult-Onset Presentations of Retinopathy Associated With Short Telomere Syndromes.,2025,10.1177/24741264251316324,https://pubmed.ncbi.nlm.nih.gov/39911301/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,39399813,Exploring prognostic implications of miRNA signatures and telomere maintenance genes in kidney cancer.,2024,10.1016/j.omton.2024.200874,https://pubmed.ncbi.nlm.nih.gov/39399813/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,36655009,Dyskeratosis congenita with heterozygous RTEL1 mutations presenting with fibrotic hypersensitivity pneumonitis.,2023,10.1016/j.rmcr.2023.101810,https://pubmed.ncbi.nlm.nih.gov/36655009/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,34021146,RTEL1 influences the abundance and localization of TERRA RNA.,2021,10.1038/s41467-021-23299-2,https://pubmed.ncbi.nlm.nih.gov/34021146/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
RTEL1,ENSG00000258366,Unsafe,35562849,"Follicular helper T cell signature of replicative exhaustion, apoptosis, and senescence in common variable immunodeficiency.",2022,10.1002/eji.202149480,https://pubmed.ncbi.nlm.nih.gov/35562849/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,40707439,Renal tubular GSDME protects cisplatin nephrotoxicity by impeding OGT-STAT3-S100A7A axis in male mice.,2025,10.1038/s41467-025-62071-8,https://pubmed.ncbi.nlm.nih.gov/40707439/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,42241629,Transcriptome dissection reveals shared upregulated genes and enriched pathways involved in skin disease concurrence.,2026,,https://pubmed.ncbi.nlm.nih.gov/42241629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,41755670,"Dermal Fibroblasts, Not Keratinocytes, Dominate IL-17A/TNF-Driven Inflammation.",2026,10.1111/exd.70232,https://pubmed.ncbi.nlm.nih.gov/41755670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,40167275,Serum circulating S100A7 and S100A15 DNA copies are elevated in patients with psoriasis and atopic dermatitis.,2025,10.1111/1346-8138.17727,https://pubmed.ncbi.nlm.nih.gov/40167275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,39778778,Renal tubular S100A7a impairs fatty acid oxidation and exacerbates renal fibrosis via both intracellular and extracellular pathway.,2025,10.1016/j.bbadis.2025.167656,https://pubmed.ncbi.nlm.nih.gov/39778778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,39168013,"Drug repositioning for rosacea disease: Biological TARGET identification, molecular docking, pharmacophore mapping, and molecular dynamics analysis.",2024,10.1016/j.compbiomed.2024.108988,https://pubmed.ncbi.nlm.nih.gov/39168013/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,36982421,"Induction of Antimicrobial Protein S100A15 Expression by Oral Microbial Pathogens Is Toll-like Receptors-Dependent Activation of c-Jun-N-Terminal Kinase (JNK), p38, and NF-κB Pathways.",2023,10.3390/ijms24065348,https://pubmed.ncbi.nlm.nih.gov/36982421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,40141352,Proteomics Reveals the Role of PLIN2 in Regulating the Secondary Hair Follicle Cycle in Cashmere Goats.,2025,10.3390/ijms26062710,https://pubmed.ncbi.nlm.nih.gov/40141352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,40821152,Generalized Pustular Psoriasis as a Systemic Inflammatory Disease: Experience With 38 Japanese Cases Over 15 Years at a Single Institution.,2025,10.7759/cureus.88108,https://pubmed.ncbi.nlm.nih.gov/40821152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,36235175,S100 Proteins as Novel Therapeutic Targets in Psoriasis and Other Autoimmune Diseases.,2022,10.3390/molecules27196640,https://pubmed.ncbi.nlm.nih.gov/36235175/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,41612675,"Violence-Related Distress, Nasal Epithelial Gene Expression, and T17-High Asthma in Youth.",2026,10.1002/ppul.71486,https://pubmed.ncbi.nlm.nih.gov/41612675/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,34830597,Increased Serum Levels of S100A4 and S100A15 in Individuals Suffering from Hidradenitis Suppurativa.,2021,10.3390/jcm10225320,https://pubmed.ncbi.nlm.nih.gov/34830597/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,40580591,Identification of the differences in molecular networks between idiopathic pulmonary fibrosis and lung squamous cell carcinoma using machine learning.,2025,10.1016/j.compbiolchem.2025.108560,https://pubmed.ncbi.nlm.nih.gov/40580591/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,40773921,Knockdown of S100A9 inhibits pyroptosis and promotes PPAR signaling pathway in atopic dermatitis.,2025,10.1016/j.bbrc.2025.152431,https://pubmed.ncbi.nlm.nih.gov/40773921/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,36928592,Elucidating the NB-UVB mechanism by comparing transcriptome alteration on the edge and center of psoriatic plaques.,2023,10.1038/s41598-023-31610-y,https://pubmed.ncbi.nlm.nih.gov/36928592/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,37180672,An integrated bioinformatics analysis of the S100 in head and neck squamous cell carcinoma.,2023,10.21037/tcr-22-1353,https://pubmed.ncbi.nlm.nih.gov/37180672/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,35563374,Transcriptomic Profiling of Peripheral Edge of Lesions to Elucidate the Pathogenesis of Psoriasis Vulgaris.,2022,10.3390/ijms23094983,https://pubmed.ncbi.nlm.nih.gov/35563374/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,30744322,Unique epithelial expression of S100A calcium binding protein A7A in the endometrium at conceptus implantation in pigs,2019,10.5713/ajas.18.0920,https://pubmed.ncbi.nlm.nih.gov/30744322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,36613589,Sericin-Based Poly(Vinyl) Alcohol Relieves Plaque and Epidermal Lesions in Psoriasis; a Chance for Dressing Development in a Specific Area.,2022,10.3390/ijms24010145,https://pubmed.ncbi.nlm.nih.gov/36613589/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,33815482,Comprehensive Analysis of the Prognosis and Correlations With Immune Infiltration of S100 Protein Family Members in Hepatocellular Carcinoma.,2021,10.3389/fgene.2021.648156,https://pubmed.ncbi.nlm.nih.gov/33815482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,36588538,Identification of an Immune-Related Gene Signature Associated with Prognosis and Tumor Microenvironment in Esophageal Cancer.,2022,10.1155/2022/7413535,https://pubmed.ncbi.nlm.nih.gov/36588538/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,31639246,Downregulation of S100a7a antimicrobial peptide in acne vulgaris patients after isotretinoin therapy.,2019,10.1111/dth.13136,https://pubmed.ncbi.nlm.nih.gov/31639246/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,34925353,Transcriptome Analysis of Host Inflammatory Responses to the Ectoparasitic Mite Sarcoptes scabiei var. hominis.,2021,10.3389/fimmu.2021.778840,https://pubmed.ncbi.nlm.nih.gov/34925353/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,28498804,Increased S100A15 expression and decreased DNA methylation of its gene promoter are involved in high metastasis potential and poor outcome of lung adenocarcinoma.,2017,10.18632/oncotarget.17391,https://pubmed.ncbi.nlm.nih.gov/28498804/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,32582097,Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes.,2020,10.3389/fmicb.2020.01155,https://pubmed.ncbi.nlm.nih.gov/32582097/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,23451142,Peripheral immune cell gene expression changes in advanced non-small cell lung cancer patients treated with first line combination chemotherapy.,2013,10.1371/journal.pone.0057053,https://pubmed.ncbi.nlm.nih.gov/23451142/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,24029918,Inflammation-mediated skin tumorigenesis induced by epidermal c-Fos.,2013,10.1101/gad.223339.113,https://pubmed.ncbi.nlm.nih.gov/24029918/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,30235356,Comprehensive molecular characterization of microneedling therapy in a human three-dimensional skin model.,2018,10.1371/journal.pone.0204318,https://pubmed.ncbi.nlm.nih.gov/30235356/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,24918694,Expression of human solute carrier family transporters in skin: possible contributor to drug-induced skin disorders.,2014,10.1038/srep05251,https://pubmed.ncbi.nlm.nih.gov/24918694/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,25620035,"Prodifferentiation, anti-inflammatory and antiproliferative effects of delphinidin, a dietary anthocyanidin, in a full-thickness three-dimensional reconstituted human skin model of psoriasis.",2015,10.1159/000368445,https://pubmed.ncbi.nlm.nih.gov/25620035/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,25897967,Transcriptional landscape of psoriasis identifies the involvement of IL36 and IL36RN.,2015,10.1186/s12864-015-1508-2,https://pubmed.ncbi.nlm.nih.gov/25897967/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,25029526,"Potential therapeutic targets for oral cancer: ADM, TP53, EGFR, LYN, CTLA4, SKIL, CTGF, CD70.",2014,10.1371/journal.pone.0102610,https://pubmed.ncbi.nlm.nih.gov/25029526/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
S100A7A,ENSG00000184330,Unsafe,20220767,Assessment of the psoriatic transcriptome in a large sample: additional regulated genes and comparisons with in vitro models.,2010,10.1038/jid.2010.36,https://pubmed.ncbi.nlm.nih.gov/20220767/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,40697225,SAC3 domain containing 1 intervention in energy metabolism reprogramming assists in the progression of hepatocellular carcinoma.,2025,10.4251/wjgo.v17.i7.107971,https://pubmed.ncbi.nlm.nih.gov/40697225/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,42196419,"Prognostic Genes Linked to Asparagine Metabolism in Hepatocellular Carcinoma: Identification, Validation, and Regulatory Mechanisms Based on Transcriptome and Single-Cell RNA Sequencing.",2026,10.3390/ijms27104425,https://pubmed.ncbi.nlm.nih.gov/42196419/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,40461549,Identification and validation of SAC3D1 as a prognostic biomarker promoting the development of osteosarcoma.,2025,10.1038/s41598-025-04390-w,https://pubmed.ncbi.nlm.nih.gov/40461549/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,40503414,Role of cell cycle-related gene &lt;i&gt;SAC3 domain containing 1&lt;/i&gt; as a potential target of nitidine chloride in hepatocellular carcinoma progression.,2025,10.5306/wjco.v16.i5.104154,https://pubmed.ncbi.nlm.nih.gov/40503414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,42261309,Identification and validation of prognostic genes related to centrosome amplification in multiple myeloma.,2026,10.7717/peerj.21283,https://pubmed.ncbi.nlm.nih.gov/42261309/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,39100078,"Conduction and validation of a novel mitotic spindle assembly related signature in hepatocellular carcinoma: prognostic prediction, tumor immune microenvironment and drug susceptibility.",2024,10.3389/fgene.2024.1412303,https://pubmed.ncbi.nlm.nih.gov/39100078/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,41301179,Computational Investigation of Smooth Muscle Cell Plasticity in Atherosclerosis and Vascular Calcification: Insights from Differential Gene Expression Analysis of Microarray Data.,2025,10.3390/bioengineering12111223,https://pubmed.ncbi.nlm.nih.gov/41301179/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,39762905,Utilizing liquid-liquid biopolymer regulators to predict the prognosis and drug sensitivity of hepatocellular carcinoma.,2025,10.1186/s13062-025-00592-4,https://pubmed.ncbi.nlm.nih.gov/39762905/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,36004462,SAC3D1 activates Wnt/β‑catenin signalling in hepatocellular carcinoma.,2022,10.3892/mmr.2022.12833,https://pubmed.ncbi.nlm.nih.gov/36004462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,36635413,Identification of diagnostic biomarkers for idiopathic pulmonary hypertension with metabolic syndrome by bioinformatics and machine learning.,2023,10.1038/s41598-023-27435-4,https://pubmed.ncbi.nlm.nih.gov/36635413/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,32319600,Upregulated expression of SAC3D1 is associated with progression in gastric cancer.,2020,10.3892/ijo.2020.5048,https://pubmed.ncbi.nlm.nih.gov/32319600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,38629071,Single-cell RNA-seq reveals T cell exhaustion and immune response landscape in osteosarcoma.,2024,10.3389/fimmu.2024.1362970,https://pubmed.ncbi.nlm.nih.gov/38629071/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,37154991,Centrosome amplification-related signature correlated with immune microenvironment and treatment response predicts prognosis and improves diagnosis of hepatocellular carcinoma by integrating machine learning and single-cell analyses.,2024,10.1007/s12072-023-10538-5,https://pubmed.ncbi.nlm.nih.gov/37154991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,34760691,Bioinformatics Analysis Using ATAC-seq and RNA-seq for the Identification of 15 Gene Signatures Associated With the Prediction of Prognosis in Hepatocellular Carcinoma.,2021,10.3389/fonc.2021.726551,https://pubmed.ncbi.nlm.nih.gov/34760691/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,30353105,SAC3D1: a novel prognostic marker in hepatocellular carcinoma.,2018,10.1038/s41598-018-34129-9,https://pubmed.ncbi.nlm.nih.gov/30353105/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,34714828,GWAS loci associated with Chagas cardiomyopathy influences DNA methylation levels.,2021,10.1371/journal.pntd.0009874,https://pubmed.ncbi.nlm.nih.gov/34714828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,33539531,A Genome-Wide Association Study Identifies Novel Susceptibility loci in Chronic Chagas Cardiomyopathy.,2021,10.1093/cid/ciab090,https://pubmed.ncbi.nlm.nih.gov/33539531/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,31496805,Identification of a novel DNA repair-related prognostic signature predicting survival of patients with hepatocellular carcinoma.,2019,10.2147/cmar.s204864,https://pubmed.ncbi.nlm.nih.gov/31496805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,25326153,Low glucose transporter SLC2A5-inhibited human normal adjacent lung adenocarcinoma cytoplasmic pro-B cell development mechanism network.,2015,10.1007/s11010-014-2233-x,https://pubmed.ncbi.nlm.nih.gov/25326153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAC3D1,ENSG00000168061,Unsafe,21220475,Digital transcript profile analysis with aRNA-LongSAGE validates FERMT1 as a potential novel prognostic marker for colon cancer.,2011,10.1158/1078-0432.ccr-10-2552,https://pubmed.ncbi.nlm.nih.gov/21220475/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42275746,Effects of Smoothened Agonist Exposure on Murine Craniofacial Development.,2026,10.1016/j.identj.2026.109671,https://pubmed.ncbi.nlm.nih.gov/42275746/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42905250,Borrelia garinii spirochetemia in a previously healthy child presenting with Streptococcus anginosus group brain abscess: a case report.,2026,10.1007/s15010-026-03016-1,https://pubmed.ncbi.nlm.nih.gov/42905250/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42727673,Injectable catechol-functionalized hyaluronic acid/layered double hydroxide nanocomposite hydrogels for regulated osteoinductive delivery and bone defect repair.,2026,10.1016/j.ijbiomac.2026.154437,https://pubmed.ncbi.nlm.nih.gov/42727673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42586812,Tumor-confined nano-activators for antigen-independent broad activation of tumor-infiltrating T cells.,2026,10.1016/j.scib.2026.07.061,https://pubmed.ncbi.nlm.nih.gov/42586812/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,41327005,A comparative transcriptomic analysis provides new insights into the ecological adaptations in Ichthyophis bannanicus.,2025,10.1186/s12864-025-12305-2,https://pubmed.ncbi.nlm.nih.gov/41327005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42765457,Selective Expansion of TCR Vβ2&lt;sup&gt;+&lt;/sup&gt; Tregs and Impaired Lymphocyte TSST-1 Responsiveness in Bullous Pemphigoid Patients Colonised by Staphylococcus aureus.,2026,10.1111/exd.70355,https://pubmed.ncbi.nlm.nih.gov/42765457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42683004,Safety of S-acetyl glutathione as an novel food pursuant to Regulation (EU) 2015/2283.,2026,10.2903/j.efsa.2026.10258,https://pubmed.ncbi.nlm.nih.gov/42683004/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42804789,Embolization of CSF-venous fistula for syrinx resolution in acquired Chiari malformation: illustrative case.,2026,10.3171/case26202,https://pubmed.ncbi.nlm.nih.gov/42804789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42814823,"Speech clocks decode dementia phenotypes, social exposome, and biological aging.",2026,10.1126/sciadv.aef9864,https://pubmed.ncbi.nlm.nih.gov/42814823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,41913328,Localized Delivery of a Small Molecule Hedgehog Agonist via Poly(ε-caprolactone) Scaffolds Enhances Tendon-to-Bone Integration.,2026,10.1002/jor.70183,https://pubmed.ncbi.nlm.nih.gov/41913328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42794401,Organic-Inorganic Hyaluronic Acid/Sumecton Nanocomposite Hydrogels for Osteogenic Applications.,2026,10.3390/gels12090851,https://pubmed.ncbi.nlm.nih.gov/42794401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,40932038,A Rare Case of Multiple Myeloma with Extramedullary Right Atrium and Testicular Involvement at Initial Diagnosis,2026,10.4274/tjh.galenos.2025.2025.0347,https://pubmed.ncbi.nlm.nih.gov/40932038/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42352918,Rapid and Robust Generation of Human Cortical Interneurons from Induced Neural Stem Cells.,2026,10.3390/ijms27125194,https://pubmed.ncbi.nlm.nih.gov/42352918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,40967912,"Human Epileptic Neurons: They Are ""Sag""-nificantly Different!",2025,10.1523/eneuro.0278-25.2025,https://pubmed.ncbi.nlm.nih.gov/40967912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,41134710,"Smoothened Agonist Treatment Mitigates Vasogenic Edema, Neuroinflammation, and Neurological Dysfunction Following Traumatic Brain Injury in Mice.",2025,10.1096/fj.202502571r,https://pubmed.ncbi.nlm.nih.gov/41134710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42690049,A uniquely human sebum lipid drives streptococcal skin infection severity.,2026,10.1128/mbio.01856-26,https://pubmed.ncbi.nlm.nih.gov/42690049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42228240,The role of cellular senescence in immune-metabolic features and prognosis of ovarian cancer: an integrated analysis based on single-cell sequencing and multi-omics data.,2026,10.1007/s11357-026-02343-3,https://pubmed.ncbi.nlm.nih.gov/42228240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42796875,Integrated Transcriptomic and Phytohormone Metabolomic Analyses Reveal Distinct Molecular States Associated with PSTVd-Induced Potato Tuber Cracking and Knob-like Protuberances at Tuber Eyes.,2026,10.3390/plants15182842,https://pubmed.ncbi.nlm.nih.gov/42796875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42860187,A Mir338-CDK8-mitochondrial axis governs lineage-specific osteogenesis and defines Runx2 pleiotropy in cranial sutures.,2026,10.1016/j.jare.2026.10.029,https://pubmed.ncbi.nlm.nih.gov/42860187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42262999,Clinical and microbiological features of Streptococcus anginosus group infections: a 7-year retrospective study in Vietnam.,2026,10.3855/jidc.21557,https://pubmed.ncbi.nlm.nih.gov/42262999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42676359,&lt;i&gt;In Silico&lt;/i&gt; design and evaluation of a multi-epitope vaccine candidate against &lt;i&gt;Toxoplasma gondii&lt;/i&gt; for humans.,2026,10.3389/fcimb.2026.1905185,https://pubmed.ncbi.nlm.nih.gov/42676359/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42188907,Advances and Translational Challenges in &lt;i&gt;Toxoplasma gondii&lt;/i&gt; Vaccine Development: From Antigen Discovery to mRNA and One Health Strategies.,2026,10.3390/vetsci13050437,https://pubmed.ncbi.nlm.nih.gov/42188907/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,40026852,Clinical potential of SAG-524: A novel HBV RNA destabilizer with a unique mechanism of action.,2025,10.35772/ghm.2024.01078,https://pubmed.ncbi.nlm.nih.gov/40026852/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42064363,"Safety and efficacy of biodegradable microneedle acupuncture for dry eye: A multicenter, randomized, active-controlled pivotal trial.",2026,10.1016/j.imr.2026.101338,https://pubmed.ncbi.nlm.nih.gov/42064363/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,41026501,Self-Adjuvanting Gel for Hierarchical Delivery to Tumors and Lymph Nodes in Liver and Colon Tumor Immunotherapy.,2025,10.1021/acsnano.5c11500,https://pubmed.ncbi.nlm.nih.gov/41026501/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,39273378,Generation of Novel Tumour-Selective SEA Superantigen-Based Peptides with Improved Safety and Efficacy for Precision Cancer Immunotherapy.,2024,10.3390/ijms25179423,https://pubmed.ncbi.nlm.nih.gov/39273378/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42513950,"Screening of the Two &lt;i&gt;Pseudochloris wilhelmii&lt;/i&gt; Strains (Adriatic SAG 55.87 and Mangrove SAG 1.80) Cultured Under a Wide Range of Conditions: Nitrogen Concentration, Nitrogen Source and Salinity.",2026,10.3390/microorganisms14071444,https://pubmed.ncbi.nlm.nih.gov/42513950/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,41724403,Staphylococcal superantigen-specific IgE reveals functional superantigen production beyond Staphylococcus aureus in CRSwNP.,2026,10.1016/j.jaci.2026.02.013,https://pubmed.ncbi.nlm.nih.gov/41724403/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42475326,Mechanical behavior of single concrete frame strengthened with externally prestressed cables.,2026,10.1371/journal.pone.0350097,https://pubmed.ncbi.nlm.nih.gov/42475326/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42574561,Intelligent Framework for Adverse Drug Event Identification Using Large Language Models and Retrieval-Augmented Generation: Development and Evaluation Study.,2026,10.2196/84086,https://pubmed.ncbi.nlm.nih.gov/42574561/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,41400599,Comparison of Early Outcomes Following Transjugular Transcatheter Tricuspid Valve Replacement Between Large vs Small Annulus.,2026,10.1016/j.jcin.2025.11.013,https://pubmed.ncbi.nlm.nih.gov/41400599/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,41019053,Two homologous sequences of Grp78 and HSP70 represent tumor antigens shared with streptococcal superantigens in eliciting an antitumor immune response: an immunoinformatic investigation.,2025,10.3389/fimmu.2025.1644687,https://pubmed.ncbi.nlm.nih.gov/41019053/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42347660,Protective Effect Against Acute Experimental Toxoplasmosis Conferred by Intranasal Immunisation with &lt;i&gt;Toxoplasma gondii&lt;/i&gt; Membrane Proteins Plus CpG Adjuvant.,2026,10.3390/vaccines14060539,https://pubmed.ncbi.nlm.nih.gov/42347660/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42442113,Safety threshold quantification for mountainous freeways: a CatBoost-SHAP framework for crash frequency modeling on combined horizontal and vertical curve alignments.,2026,10.1016/j.aap.2026.108675,https://pubmed.ncbi.nlm.nih.gov/42442113/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42019996,Sanguinarine triggers apoptosis and ferroptosis synchronously by directly binding BiP in lung squamous cell carcinoma.,2026,10.1016/s1875-5364(26)61115-6,https://pubmed.ncbi.nlm.nih.gov/42019996/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,41808162,Cellular senescence in gastric cancer: a novel prognostic stratification and immune predictor.,2026,10.1186/s12920-026-02346-1,https://pubmed.ncbi.nlm.nih.gov/41808162/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42495991,Contemporary evidence for multiarterial grafting in coronary artery bypass surgery.,2026,10.1097/hco.0000000000001318,https://pubmed.ncbi.nlm.nih.gov/42495991/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,42346498,Does Total Arterial Revascularisation Confer a Survival Advantage in Moderate Left Ventricular Dysfunction? A Retrospective Cohort Study of 1866 Patients.,2026,10.3390/jcdd13060278,https://pubmed.ncbi.nlm.nih.gov/42346498/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAG,ENSG00000130561,Unsafe,3720866,Ultrastructural localization of retinal S antigen in the human retina.,1986,10.1016/0014-4835(86)90007-2,https://pubmed.ncbi.nlm.nih.gov/3720866/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD15,ENSG00000100583,Unsafe,37116672,Prospective Blood Transcriptomics Study in a Motor Vehicle Collision Cohort Identified a Protective Function of the SAMD15 Gene Against Chronic Pain.,2023,10.1016/j.jpain.2023.04.009,https://pubmed.ncbi.nlm.nih.gov/37116672/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,40252130,Identification and validation of poor prognosis immunoevasive subtype of esophageal cancer with tumor-infiltrating SAMD3 + NK cell abundance.,2025,10.1007/s00262-025-04028-w,https://pubmed.ncbi.nlm.nih.gov/40252130/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,39891760,Elevated SAMD3 expression in T cells predicts improved survival in pancreatic ductal adenocarcinoma patients.,2025,10.1007/s00262-025-03948-x,https://pubmed.ncbi.nlm.nih.gov/39891760/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,41230044,Uterine NK Cell Polarization Associates with Chronic Endometritis and Predisposition to Recurrent Implantation Failure.,2025,10.2147/ijwh.s554069,https://pubmed.ncbi.nlm.nih.gov/41230044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,39814037,"1α,25(OH)2D3 Regulates the TGF-β1/Samd Signaling Pathway Inhibition of Hepatic Stellate Cell Activation.",2025,10.1055/a-2463-5530,https://pubmed.ncbi.nlm.nih.gov/39814037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,40055915,Gastrodin inhibits reactive astrocyte-mediated inflammation in hypoxic-ischemic brain damage through S100B/RAGE-Smad3 signaling.,2025,10.3724/abbs.2024235,https://pubmed.ncbi.nlm.nih.gov/40055915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,36918563,Screening of potential immune-related genes expressed during sepsis using gene sequencing technology.,2023,10.1038/s41598-022-23062-7,https://pubmed.ncbi.nlm.nih.gov/36918563/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,34626120,A multifunctional mouse model to study the role of Samd3.,2022,10.1002/eji.202149469,https://pubmed.ncbi.nlm.nih.gov/34626120/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,37612620,Genome-wide analysis of circRNA regulation during spleen development of Chinese indigenous breed Meishan pigs.,2023,10.1186/s12864-023-09612-x,https://pubmed.ncbi.nlm.nih.gov/37612620/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,39743186,Astragali Radix-Angelicae Sinensis Radix inhibits the activation of vascular adventitial fibroblasts and vascular intimal proliferation by regulating the TGF-β1/Smad2/3 pathway.,2025,10.1016/j.jep.2024.119302,https://pubmed.ncbi.nlm.nih.gov/39743186/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,38670449,Zinc oxide nanoparticles prevent the onset of diabetic nephropathy by inhibiting multiple pathways associated with oxidative stress.,2024,10.1016/j.lfs.2024.122667,https://pubmed.ncbi.nlm.nih.gov/38670449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,38888716,Dahuang Zhechong Pill Alleviates Liver Fibrosis Progression by Regulating p38 MAPK/NF-κ B/TGF-β1 Pathway.,2024,10.1007/s11655-024-3801-x,https://pubmed.ncbi.nlm.nih.gov/38888716/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,37562291,Effect of X-ray irradiation combined with PD-1 inhibitor treatment on lung tissue injury in mice.,2023,10.1016/j.intimp.2023.110775,https://pubmed.ncbi.nlm.nih.gov/37562291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,36733505,Gastrodin attenuates renal injury and collagen deposition via suppression of the TGF-β1/Smad2/3 signaling pathway based on network pharmacology analysis.,2023,10.3389/fphar.2023.1082281,https://pubmed.ncbi.nlm.nih.gov/36733505/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,38555283,"Network pharmacology, computational biology integrated surface plasmon resonance technology reveals the mechanism of ellagic acid against rotavirus.",2024,10.1038/s41598-024-58301-6,https://pubmed.ncbi.nlm.nih.gov/38555283/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,35330412,Multi-Omics Characterization of Early- and Adult-Onset Major Depressive Disorder.,2022,10.3390/jpm12030412,https://pubmed.ncbi.nlm.nih.gov/35330412/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,33495412,Adipose-derived stromal cells improve functional recovery after spinal cord injury through TGF-β1/Smad3/PLOD2 pathway activation.,2021,10.18632/aging.202399,https://pubmed.ncbi.nlm.nih.gov/33495412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,34938356,Bioinformatics-Based Analysis of lncRNA-mRNA Interaction Network of Mild Hepatic Encephalopathy in Cirrhosis.,2021,10.1155/2021/7777699,https://pubmed.ncbi.nlm.nih.gov/34938356/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,38965845,[Single-cell transcriptomic sequencing coupled with Mendelian randomization analysis elucidates the pivotal role of CTSC in chronic rhinosinusitis].,2024,10.3760/cma.j.cn115330-20231211-00285,https://pubmed.ncbi.nlm.nih.gov/38965845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,37088770,[Effects of Bu Zhong Yi Qi decoction on CIH-induced interstitial lung fibrosis in mice].,2022,10.12047/j.cjap.6316.2022.104,https://pubmed.ncbi.nlm.nih.gov/37088770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,31186655,The Wound Healing Effect of Callicarpa nudiflora in Scalded Rats.,2019,10.1155/2019/1860680,https://pubmed.ncbi.nlm.nih.gov/31186655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,38006352,"Nuciferine Protects against Obesity-Induced Nephrotoxicity through Its Hypolipidemic, Anti-Inflammatory, and Antioxidant Effects.",2023,10.1021/acs.jafc.3c05735,https://pubmed.ncbi.nlm.nih.gov/38006352/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,29654657,Hepatoprotective effect of Herpetospermum caudigerum Wall. on carbon tetrachloride-induced hepatic fibrosis in rats.,2018,10.1111/jcmm.13568,https://pubmed.ncbi.nlm.nih.gov/29654657/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,29499953,MicroRNA-140 Inhibits the Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.,2018,10.1016/j.omtn.2017.12.022,https://pubmed.ncbi.nlm.nih.gov/29499953/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD3,ENSG00000164483,Unsafe,28049506,Novel derivative of aminobenzenesulfonamide (3c) induces apoptosis in colorectal cancer cells through ROS generation and inhibits cell migration.,2017,10.1186/s12885-016-3005-7,https://pubmed.ncbi.nlm.nih.gov/28049506/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,42486354,Samd7 is dispensable for spermatogenesis and male fertility in mice.,2026,10.1016/j.cdev.2026.204098,https://pubmed.ncbi.nlm.nih.gov/42486354/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,39531499,&lt;i&gt;Samd7&lt;/i&gt; represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity.,2024,10.1073/pnas.2402121121,https://pubmed.ncbi.nlm.nih.gov/39531499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,38272031,Mutations in SAMD7 cause autosomal-recessive macular dystrophy with or without cone dysfunction.,2024,10.1016/j.ajhg.2024.01.001,https://pubmed.ncbi.nlm.nih.gov/38272031/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,39814037,"1α,25(OH)2D3 Regulates the TGF-β1/Samd Signaling Pathway Inhibition of Hepatic Stellate Cell Activation.",2025,10.1055/a-2463-5530,https://pubmed.ncbi.nlm.nih.gov/39814037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,40020829,Whole-exome sequencing identifies EP300 variants associated with visceral leishmaniasis relapse.,2025,10.1016/j.ijbiomac.2025.141533,https://pubmed.ncbi.nlm.nih.gov/40020829/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,39103437,Functional genetic variants and susceptibility and prediction of gestational diabetes mellitus.,2024,10.1038/s41598-024-69079-y,https://pubmed.ncbi.nlm.nih.gov/39103437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,40744127,Population structure and signature of selection for body size in some Iranian and exotic horse breeds.,2025,10.1016/j.jevs.2025.105658,https://pubmed.ncbi.nlm.nih.gov/40744127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,40250431,Avian photoreceptor homologies and the origin of double cones.,2025,10.1016/j.cub.2025.02.040,https://pubmed.ncbi.nlm.nih.gov/40250431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,39743186,Astragali Radix-Angelicae Sinensis Radix inhibits the activation of vascular adventitial fibroblasts and vascular intimal proliferation by regulating the TGF-β1/Smad2/3 pathway.,2025,10.1016/j.jep.2024.119302,https://pubmed.ncbi.nlm.nih.gov/39743186/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,33603070,"Functional analysis of Samd11, a retinal photoreceptor PRC1 component, in establishing rod photoreceptor identity.",2021,10.1038/s41598-021-83781-1,https://pubmed.ncbi.nlm.nih.gov/33603070/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,28900001,Samd7 is a cell type-specific PRC1 component essential for establishing retinal rod photoreceptor identity.,2017,10.1073/pnas.1707021114,https://pubmed.ncbi.nlm.nih.gov/28900001/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,26887858,Autosomal recessive retinitis pigmentosa with homozygous rhodopsin mutation E150K and non-coding cis-regulatory variants in CRX-binding regions of SAMD7.,2016,10.1038/srep21307,https://pubmed.ncbi.nlm.nih.gov/26887858/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,31210714,Endoscopic resection of the pancreatic tail and subsequent wound healing mechanisms in a porcine model.,2019,10.3748/wjg.v25.i21.2623,https://pubmed.ncbi.nlm.nih.gov/31210714/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,23565263,Sterile alpha motif containing 7 (samd7) is a novel crx-regulated transcriptional repressor in the retina.,2013,10.1371/journal.pone.0060633,https://pubmed.ncbi.nlm.nih.gov/23565263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,36603342,"Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-β/Smad signaling.",2023,10.1016/j.phymed.2022.154626,https://pubmed.ncbi.nlm.nih.gov/36603342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,33377720,"[Regulatory effect of Qianliexiao Decoction on TGF-β1, Smad4 and Smad 7 signaling pathways and the proliferation and apoptosis of prostate fibroblasts in mice with experimental autoimmune prostatitis].",2020,,https://pubmed.ncbi.nlm.nih.gov/33377720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,22619697,Desferrioxamine attenuates doxorubicin-induced acute cardiotoxicity through TFG-β/Smad p53 pathway in rat model.,2012,10.1155/2012/619185,https://pubmed.ncbi.nlm.nih.gov/22619697/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,24783520,[Relationship between artesunate influence on the process of TGF-beta1 induced alveolar epithelial cells transform into mesenchymal cells and on idiopathic pulmonary fibrosis].,2014,,https://pubmed.ncbi.nlm.nih.gov/24783520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAMD7,ENSG00000187033,Unsafe,17347560,Arkadia-Smad7-mediated positive regulation of TGF-beta signaling in a rat model of tubulointerstitial fibrosis.,2007,10.1159/000100518,https://pubmed.ncbi.nlm.nih.gov/17347560/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,42220212,Multiple mechanisms lead to loss-of-function effects of pathogenic SARS2 variants.,2026,10.1242/dmm.052690,https://pubmed.ncbi.nlm.nih.gov/42220212/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,42530330,ACE2-fused nanobody targeting a cryptic RBD epitope broadly neutralizes SARS-like viruses.,2026,10.1128/jvi.00608-26,https://pubmed.ncbi.nlm.nih.gov/42530330/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,41536252,Brain-peripheral proteome crosstalk in Alzheimer's disease with and without diabetes mellitus.,2026,10.1002/alz.70959,https://pubmed.ncbi.nlm.nih.gov/41536252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,42421394,Mitochondria-related pathogenic genes in acute and chronic kidney disease: a Mendelian randomization study.,2026,10.1080/0886022x.2026.2698274,https://pubmed.ncbi.nlm.nih.gov/42421394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,41289788,"Identification of SARS2, PKN1, and IL11RA as causally-associated genes for patients with gastric cancer via immune cell activity: A multi-omics Mendelian randomization study integrating GWAS, eQTL, and pQTL data.",2025,10.1016/j.ctarc.2025.101042,https://pubmed.ncbi.nlm.nih.gov/41289788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,40365287,Investigating post-infection anxiety- and depression-like behaviors in a SARS-CoV-2 mouse model.,2025,10.7150/thno.102752,https://pubmed.ncbi.nlm.nih.gov/40365287/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,42037412,"SARS-CoV-2 3CLpro mutations T21I and E166A confer differential resistance to simnotrelvir, bofutrelvir, and ensitrelvir.",2026,10.1128/jvi.02223-25,https://pubmed.ncbi.nlm.nih.gov/42037412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,39704169,Early antiviral CD4+ and CD8+ T cells are associated with upper airway clearance of SARS-CoV-2.,2024,10.1172/jci.insight.186078,https://pubmed.ncbi.nlm.nih.gov/39704169/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,40234727,Genetic associations of plasma proteins and breast cancer identify potential therapeutic drug candidates.,2025,10.1038/s42003-025-08046-3,https://pubmed.ncbi.nlm.nih.gov/40234727/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,39459161,SARS-CoV-2 Nucleocapsid Protein Antagonizes GADD34-Mediated Innate Immune Pathway through Atypical Foci.,2024,10.3390/molecules29204792,https://pubmed.ncbi.nlm.nih.gov/39459161/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,38172120,TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.,2024,10.1038/s41467-023-44502-6,https://pubmed.ncbi.nlm.nih.gov/38172120/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,42267415,TXD-198 Exhibits Inhibitory Activity Against SARS-CoV-2 by Upregulating ANO1.,2026,10.1002/jmv.71004,https://pubmed.ncbi.nlm.nih.gov/42267415/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,41096790,Evaluation of Serum FGF21 Levels in Patients with Mitochondrial Aminoacyl-tRNA Synthetase Deficiency.,2025,10.3390/ijms26199525,https://pubmed.ncbi.nlm.nih.gov/41096790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,38264205,Variants in the SARS2 gene cause HUPRA syndrome with atypical features: two case reports and review of the literature.,2023,10.1093/omcr/omad119,https://pubmed.ncbi.nlm.nih.gov/38264205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,39629990,Mucosal SARS-CoV-2 S1 adenovirus-based vaccine elicits robust systemic and mucosal immunity and protects against disease in animals.,2025,10.1128/mbio.02170-24,https://pubmed.ncbi.nlm.nih.gov/39629990/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,38932334,A Unique mRNA Vaccine Elicits Protective Efficacy against the SARS-CoV-2 Omicron Variant and SARS-CoV.,2024,10.3390/vaccines12060605,https://pubmed.ncbi.nlm.nih.gov/38932334/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,41197737,A split luciferase system for studying coronavirus M&lt;sup&gt;pro&lt;/sup&gt; dimerization in vitro and in living cells.,2025,10.1016/j.jbc.2025.110890,https://pubmed.ncbi.nlm.nih.gov/41197737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,36350636,Selective degradation of tRNASer(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease.,2022,10.1093/nar/gkac1028,https://pubmed.ncbi.nlm.nih.gov/36350636/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,41667644,Structural basis for bat receptor recognition by SARS-CoV-2 and bat SARS2-like coronaviruses.,2026,10.1038/s42003-026-09682-z,https://pubmed.ncbi.nlm.nih.gov/41667644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,35967447,BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike protein.,2022,10.3389/fimmu.2022.919815,https://pubmed.ncbi.nlm.nih.gov/35967447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,41808839,Harnessing SARS-CoV-2 immunity to promote antitumor responses through intratumoral vaccination and adoptive transfer.,2026,10.3389/fimmu.2026.1711569,https://pubmed.ncbi.nlm.nih.gov/41808839/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,42885535,A multiscale mechanical model for flexible spike protein-mediated SARS-CoV-2 viral entry into host cells.,2026,10.1039/d6sm00692b,https://pubmed.ncbi.nlm.nih.gov/42885535/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,38781962,"SARS-CoV-2 breakthrough infections enhance T cell response magnitude, breadth, and epitope repertoire.",2024,10.1016/j.xcrm.2024.101583,https://pubmed.ncbi.nlm.nih.gov/38781962/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,39405115,Tissue-resident memory T cells contribute to protection against heterologous SARS-CoV-2 challenge.,2024,10.1172/jci.insight.184074,https://pubmed.ncbi.nlm.nih.gov/39405115/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,39843371,Global vaccine research and application hotspots and trends: a systematic bibliometric analysis based on SCIE highly cited papers.,2025,10.1136/bmjopen-2024-094935,https://pubmed.ncbi.nlm.nih.gov/39843371/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,40266218,Glycosylated Receptor-Binding-Domain-Targeting Mucosal Vaccines Protect Against SARS-CoV-2 Omicron and MERS-CoV.,2025,10.3390/vaccines13030293,https://pubmed.ncbi.nlm.nih.gov/40266218/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,40488365,The Data are Insufficient to Confidently Root the SARS-CoV-2 Phylogenetic Tree.,2025,10.1093/molbev/msaf118,https://pubmed.ncbi.nlm.nih.gov/40488365/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,37515096,LSDV-Vectored SARS-CoV-2 S and N Vaccine Protects against Severe Clinical Disease in Hamsters.,2023,10.3390/v15071409,https://pubmed.ncbi.nlm.nih.gov/37515096/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,36321826,Mucosal and Systemic Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination Determined by Severity of Primary Infection.,2022,10.1128/msphere.00279-22,https://pubmed.ncbi.nlm.nih.gov/36321826/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,36069348,A replication-competent smallpox vaccine LC16m8Δ-based COVID-19 vaccine.,2022,10.1080/22221751.2022.2122580,https://pubmed.ncbi.nlm.nih.gov/36069348/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,35893821,Intranasal Immunization with a Vaccinia Virus Vaccine Vector Expressing Pre-Fusion Stabilized SARS-CoV-2 Spike Fully Protected Mice against Lethal Challenge with the Heavily Mutated Mouse-Adapted SARS2-N501YMA30 Strain of SARS-CoV-2.,2022,10.3390/vaccines10081172,https://pubmed.ncbi.nlm.nih.gov/35893821/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,35282925,Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine.,2022,10.1016/j.vaccine.2021.12.063,https://pubmed.ncbi.nlm.nih.gov/35282925/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SARS2,ENSG00000104835,Unsafe,39173830,SARS-CoV-2 M&lt;sup&gt;pro&lt;/sup&gt; inhibitor identification using a cellular gain-of-signal assay for high-throughput screening.,2024,10.1016/j.slasd.2024.100181,https://pubmed.ncbi.nlm.nih.gov/39173830/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,41453690,FBXW7 E3 ligase prevents centriole overduplication by degrading the Plk4 phosphorylated STIL-SAS6 cartwheel assembly.,2026,10.1016/j.jbc.2025.111104,https://pubmed.ncbi.nlm.nih.gov/41453690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,39443355,SASS6 promotes tumor proliferation and is associated with TP53 and immune infiltration in lung adenocarcinoma.,2024,10.1007/s10238-024-01510-0,https://pubmed.ncbi.nlm.nih.gov/39443355/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,41319860,CDT1 induces the formation of polyploid giant cancer cells and promotes centrosome amplification through the PLK4/SASS6 axis.,2026,10.1016/j.canlet.2025.218186,https://pubmed.ncbi.nlm.nih.gov/41319860/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,40825584,Dysregulated &lt;i&gt;SASS6&lt;/i&gt; expression promotes increased ciliogenesis and cell invasion phenotypes.,2025,10.26508/lsa.202402820,https://pubmed.ncbi.nlm.nih.gov/40825584/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,41466703,Identification of upregulated genes in pulmonary hypertension using RNA sequencing profiling.,2025,10.6026/973206300213105,https://pubmed.ncbi.nlm.nih.gov/41466703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,36739862,Case Report: Prenatal Recurrent Microcephaly and Corpus Callosum Abnormalities in a Chinese Family with Novel Biallelic SASS6 Mutations.,2023,10.1159/000529504,https://pubmed.ncbi.nlm.nih.gov/36739862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,41644695,McIdas localizes to centrioles and controls centriole numbers through PLK4-dependent phosphorylation.,2026,10.1038/s44319-026-00697-5,https://pubmed.ncbi.nlm.nih.gov/41644695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,40281964,Molecular Mechanism of the &lt;i&gt;Grid&lt;/i&gt; Gene Family Regulating Growth Size Heteromorphism in &lt;i&gt;Cynoglossus semilaevis&lt;/i&gt;.,2025,10.3390/ani15081130,https://pubmed.ncbi.nlm.nih.gov/40281964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,39289669,High ratio of resident to exhausted CD4 + T cells predicts favorable prognosis and potentially better immunotherapeutic efficacy in hepatocellular carcinoma.,2024,10.1186/s12885-024-12916-0,https://pubmed.ncbi.nlm.nih.gov/39289669/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,38407237,Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells.,2024,10.7554/elife.94694,https://pubmed.ncbi.nlm.nih.gov/38407237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,39904373,Interactions of N- and C-terminal parts of Ana1 permitting centriole duplication but not elongation.,2025,10.1098/rsob.240325,https://pubmed.ncbi.nlm.nih.gov/39904373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,36331102,Targeting Drosophila Sas6 to mitochondria reveals its high affinity for Gorab.,2022,10.1242/bio.059545,https://pubmed.ncbi.nlm.nih.gov/36331102/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,38177679,The Ruminococcus bromii amylosome protein Sas6 binds single and double helical α-glucan structures in starch.,2024,10.1038/s41594-023-01166-6,https://pubmed.ncbi.nlm.nih.gov/38177679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,37279547,"A primary microcephaly-associated sas-6 mutation perturbs centrosome duplication, dendrite morphogenesis, and ciliogenesis in Caenorhabditis elegans.",2023,10.1093/genetics/iyad105,https://pubmed.ncbi.nlm.nih.gov/37279547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,33907854,Knockdown of SASS6 reduces growth of MDA‑MB‑231 triple‑negative breast cancer cells through arrest of the cell cycle at the G2/M phase.,2021,10.3892/or.2021.8052,https://pubmed.ncbi.nlm.nih.gov/33907854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,34260288,"E2F4's cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6.",2021,10.1091/mbc.e21-01-0039,https://pubmed.ncbi.nlm.nih.gov/34260288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,33704067,The dimeric Golgi protein Gorab binds to Sas6 as a monomer to mediate centriole duplication.,2021,10.7554/elife.57241,https://pubmed.ncbi.nlm.nih.gov/33704067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,32671379,SASS6 promotes proliferation of esophageal squamous carcinoma cells by inhibiting the p53 signaling pathway.,2021,10.1093/carcin/bgaa067,https://pubmed.ncbi.nlm.nih.gov/32671379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,33171067,Interaction interface in the C-terminal parts of centriole proteins Sas6 and Ana2.,2020,10.1098/rsob.200221,https://pubmed.ncbi.nlm.nih.gov/33171067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,32375023,CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions.,2020,10.1016/j.str.2020.04.010,https://pubmed.ncbi.nlm.nih.gov/32375023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SASS6,ENSG00000156876,Unsafe,29496738,An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly.,2018,10.1083/jcb.201605106,https://pubmed.ncbi.nlm.nih.gov/29496738/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAXO1,ENSG00000155875,Unsafe,40421755,SAXO proteins mediate tubulin turnover in axonemal microtubules of Chlamydomonas.,2025,10.1242/jcs.264074,https://pubmed.ncbi.nlm.nih.gov/40421755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAXO1,ENSG00000155875,Unsafe,32814578,Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets.,2020,10.1186/s12915-020-00826-z,https://pubmed.ncbi.nlm.nih.gov/32814578/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAXO1,ENSG00000155875,Unsafe,34496252,Atypical laminin spots and pull-generated microtubule-actin projections mediate Drosophila wing adhesion.,2021,10.1016/j.celrep.2021.109667,https://pubmed.ncbi.nlm.nih.gov/34496252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAXO1,ENSG00000155875,Unsafe,33200789,Acetylation/deacetylation and microtubule associated proteins influence flagellar axonemal stability and sperm motility.,2020,10.1042/bsr20202442,https://pubmed.ncbi.nlm.nih.gov/33200789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAXO1,ENSG00000155875,Unsafe,21959382,Exome sequencing and subsequent association studies identify five amino acid-altering variants influencing human height.,2012,10.1007/s00439-011-1096-4,https://pubmed.ncbi.nlm.nih.gov/21959382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAXO1,ENSG00000155875,Unsafe,25673876,Human FAM154A (SAXO1) is a microtubule-stabilizing protein specific to cilia and related structures.,2015,10.1242/jcs.155143,https://pubmed.ncbi.nlm.nih.gov/25673876/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAXO4,ENSG00000162148,Unsafe,42201145,Methadone Maintenance Treatment vs. Long-Term Abstinence Without Opioid Agonist: Epigenome-Wide Study of DNA Methylation.,2026,10.3390/epigenomes10020029,https://pubmed.ncbi.nlm.nih.gov/42201145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAXO4,ENSG00000162148,Unsafe,41566508,IIIG9 and PP1α form a protein complex in the adherens junctions of polarized ependymal and MDCK cells.,2026,10.1186/s12987-026-00762-0,https://pubmed.ncbi.nlm.nih.gov/41566508/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAXO4,ENSG00000162148,Unsafe,38835510,Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility.,2024,10.3389/fcell.2024.1411162,https://pubmed.ncbi.nlm.nih.gov/38835510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAXO4,ENSG00000162148,Unsafe,36544342,The First Case Report of JAK2-BCR-PPP1R32 Fusion Genes Because of a Translocation (9;22;11)(p24;q11.2;q13) in a Patient With Myeloproliferative Neoplasm.,2023,10.3343/alm.2023.43.3.295,https://pubmed.ncbi.nlm.nih.gov/36544342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAXO4,ENSG00000162148,Unsafe,40421755,SAXO proteins mediate tubulin turnover in axonemal microtubules of Chlamydomonas.,2025,10.1242/jcs.264074,https://pubmed.ncbi.nlm.nih.gov/40421755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAXO4,ENSG00000162148,Unsafe,34535732,IIIG9 inhibition in adult ependymal cells changes adherens junctions structure and induces cellular detachment.,2021,10.1038/s41598-021-97948-3,https://pubmed.ncbi.nlm.nih.gov/34535732/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAXO4,ENSG00000162148,Unsafe,28194645,"Expression of a Novel Ciliary Protein, IIIG9, During the Differentiation and Maturation of Ependymal Cells.",2018,10.1007/s12035-017-0434-5,https://pubmed.ncbi.nlm.nih.gov/28194645/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SAXO4,ENSG00000162148,Unsafe,28000566,Inferring Alcoholism SNPs and Regulatory Chemical Compounds Based on Ensemble Bayesian Network.,2017,10.2174/1386207319666161220114917,https://pubmed.ncbi.nlm.nih.gov/28000566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42804440,Comparative study on the clinical effectiveness of low-concentration cyclosporine eye drops in patients with dry eye disease.,2026,10.1371/journal.pone.0358007,https://pubmed.ncbi.nlm.nih.gov/42804440/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42741679,"Phase I Randomized Study of SCAI-005 Ophthalmic Solution: Safety, Tolerability, and Pharmacokinetics in Healthy Korean Adults.",2026,10.1016/j.xops.2026.101358,https://pubmed.ncbi.nlm.nih.gov/42741679/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42666939,Fifth Universal Definition of Myocardial Infarction (2026): On behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS) and the Society of Thoracic Surgeons (STS) Affirmation of Value by the Society for Cardiovascular Angiography and Interventions (SCAI).,2026,10.5334/gh.1578,https://pubmed.ncbi.nlm.nih.gov/42666939/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42868968,Enhanced Early Risk Stratification in Cardiogenic Shock Using Machine Learning: A Hierarchical Clustering Analysis.,2026,10.1016/j.jacadv.2026.103339,https://pubmed.ncbi.nlm.nih.gov/42868968/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42589920,Factors Associated with Progression to SCAI-Defined Hemodynamic Instability at 72 Hours in Patients with Acute Decompensated Heart Failure Receiving Inotropic Therapy.,2026,10.3390/jcm15155816,https://pubmed.ncbi.nlm.nih.gov/42589920/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42156639,Intra-Arterial Selective Hypothermic Human Serum Albumin Perfusion Attenuates Cerebral Ischemia-Reperfusion Injury.,2026,10.1007/s12975-026-01450-9,https://pubmed.ncbi.nlm.nih.gov/42156639/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42694896,The Role of PoCUS in the Diagnosis and Early Monitoring of Cardiogenic Shock in the Emergency Department: A Narrative Review.,2026,10.31083/rcm50103,https://pubmed.ncbi.nlm.nih.gov/42694896/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,41584602,Sequential salvage systemic therapy after immunotherapy in head and neck cancer: a real-world study.,2025,10.3389/fonc.2025.1719793,https://pubmed.ncbi.nlm.nih.gov/41584602/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,40401145,scAI-SNP: a method for inferring ancestry from single-cell data.,2025,10.1186/s44330-025-00029-4,https://pubmed.ncbi.nlm.nih.gov/40401145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42221802,Risk Stratification in Predicting Cardiogenic Shock 30-Day Mortality admitted to ICU: beyond the Prognostic Performance of SHARC and SCAI Classifications.,2026,10.1016/j.aicoj.2026.100090,https://pubmed.ncbi.nlm.nih.gov/42221802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42612609,Prognostic Significance of Plasma Lactate Levels in Postcardiotomy Patients.,2026,10.1016/j.jacadv.2026.103158,https://pubmed.ncbi.nlm.nih.gov/42612609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,41324047,"SCAI Door to Lactate Clearance (SCAI DLC) Cardiogenic Shock Initiative: Definition, Hypothesis, and Call to Action.",2025,10.1016/j.jscai.2025.103996,https://pubmed.ncbi.nlm.nih.gov/41324047/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42799284,Rapid Treatment of Acute Decompensated Heart Failure with Cardiogenic Shock in the Emergency Setting.,2026,10.26502/fccm.92920505,https://pubmed.ncbi.nlm.nih.gov/42799284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42238621,Exploration of the Clinical Assessment and Prognostic Value of Society for Cardiovascular Angiography and Intervention Shock Staging in Patients With Acute Myocardial Infarction and Cardiogenic Shock on Veno-arterial Extracorporeal Membrane Oxygenation Support.,2026,10.31083/rcm46066,https://pubmed.ncbi.nlm.nih.gov/42238621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,40790418,"Perceived Stress, Stress Coping Strategies, and Body Image Among Facial Dermatosis.",2025,10.5826/dpc.1503a5054,https://pubmed.ncbi.nlm.nih.gov/40790418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,41726055,Comparison of Different SCAI SHOCK Stage Classification Systems in Patients With Cardiogenic Shock.,2026,10.1016/j.jscai.2025.104119,https://pubmed.ncbi.nlm.nih.gov/41726055/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,41083288,Prognostic impact of SCAI shock severity classes in AMI-related cardiogenic shock: A sub-study of the ECLS-SHOCK Trial.,2025,10.1002/ehf2.15446,https://pubmed.ncbi.nlm.nih.gov/41083288/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,40894343,Predictive value of the cardiogenic shock working group-modified SCAI criteria in early-stage heart failure-related cardiogenic shock.,2025,10.1016/j.ijcha.2025.101776,https://pubmed.ncbi.nlm.nih.gov/40894343/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42191016,Intubation Rather Than Cardiac Arrest as a Risk-Modifier of Mortality in Infarction-Related Cardiogenic Shock.,2026,10.1016/j.cardfail.2026.05.007,https://pubmed.ncbi.nlm.nih.gov/42191016/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,41994715,Cardiogenic Shock (SCAI Stage D) Following Pharmacological Reperfusion of Anterior ST-Segment Elevation Myocardial Infarction in a Young Woman: A Case Report.,2026,10.7759/cureus.105095,https://pubmed.ncbi.nlm.nih.gov/41994715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42765398,Phenotypes of cardiogenic shock after out-of-hospital cardiac arrest: the SCAI-V classification.,2026,10.4244/eij-d-26-00092,https://pubmed.ncbi.nlm.nih.gov/42765398/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42165470,Progressive Conduction Disease on Serial ECGs Revealing Immune Checkpoint Inhibitor-Associated Myocarditis and Myositis.,2026,10.1016/j.jaccas.2026.107825,https://pubmed.ncbi.nlm.nih.gov/42165470/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,41318762,Randomized double-blind crossover trial of a transdermal maltose dissolvable microneedle patch for topical anesthesia before intravenous cannulation for thalassemia children.,2025,10.1038/s41598-025-30279-9,https://pubmed.ncbi.nlm.nih.gov/41318762/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42602635,Corrigendum to 'SCAI 2026 Scientific Sessions Abstracts' [Journal of the Society for Cardiovascular Angiography &amp; Interventions 5/4S (2026)].,2026,10.1016/j.jscai.2026.105449,https://pubmed.ncbi.nlm.nih.gov/42602635/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42553684,Clinical outcomes of Impella 5+ in acute myocardial infarction-related cardiogenic shock: a retrospective single-center study.,2026,10.3389/fcvm.2026.1840979,https://pubmed.ncbi.nlm.nih.gov/42553684/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42452710,Practical Management in Coronary In-Stent Restenosis: A Narrative Review.,2026,10.3390/jcm15135250,https://pubmed.ncbi.nlm.nih.gov/42452710/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,41085472,Haemodynamic effects of istaroxime in SCAI stage B HF-related cardiogenic shock: Insights from the SEISMiC trial.,2025,10.1002/ehf2.15448,https://pubmed.ncbi.nlm.nih.gov/41085472/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42626300,SCAI/ASE/HRS/SIR/SVS Expert Consensus Statement on Enhanced Radiation Protection: Time for Mandatory and Urgent Action.,2026,10.1016/j.jscai.2026.105455,https://pubmed.ncbi.nlm.nih.gov/42626300/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,41815572,Safety and clinical outcomes of micro-axial intravascular flow pump compared to intra-aortic balloon pump in cardiogenic shock.,2026,10.21037/cdt-2025-302,https://pubmed.ncbi.nlm.nih.gov/41815572/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,42870411,Temporary mechanical circulatory support in cardiogenic shock.,2026,10.1093/eurheartj/ehag708,https://pubmed.ncbi.nlm.nih.gov/42870411/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCAI,ENSG00000173611,Unsafe,41187145,"The efficacy and safety of lignocaine-embedded dissolvable microneedle versus EMLA for topical analgesia in adults undergoing venepuncture: A single-centre, parallel-group, double-blind randomised clinical trial protocol in a tertiary care setting.",2025,10.1371/journal.pone.0335932,https://pubmed.ncbi.nlm.nih.gov/41187145/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,42913014,SCML2 inhibits PrimPol-mediated DNA replication repriming and regulates replication gap-associated cancer cell vulnerability.,2026,10.1126/sciadv.aee4738,https://pubmed.ncbi.nlm.nih.gov/42913014/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,41088683,Construction of a prediction model for hepatocellular carcinoma based on machine learning and its prognostic characteristics.,2025,10.1097/md.0000000000044966,https://pubmed.ncbi.nlm.nih.gov/41088683/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,40033153,CTCF-mediated 3D chromatin sets up the gene expression program in the male germline.,2025,10.1038/s41594-025-01482-z,https://pubmed.ncbi.nlm.nih.gov/40033153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,40282252,Integration of Microarray and Single-Cell RNA-Seq Data and Machine Learning Allows the Identification of Key Histone Modification Gene Changes in Spermatogonial Stem Cells.,2025,10.3390/biology14040387,https://pubmed.ncbi.nlm.nih.gov/40282252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,37283086,Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin.,2023,10.1093/nar/gkad479,https://pubmed.ncbi.nlm.nih.gov/37283086/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,37810219,Discordant interactions between YAP1 and polycomb group protein SCML2 determine cell fate.,2023,10.1016/j.isci.2023.107964,https://pubmed.ncbi.nlm.nih.gov/37810219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,39607422,METTL16 is Required for Meiotic Sex Chromosome Inactivation and DSB Formation and Recombination during Male Meiosis.,2025,10.1002/advs.202406332,https://pubmed.ncbi.nlm.nih.gov/39607422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,37353627,SCML2 contributes to tumor cell resistance to DNA damage through regulating p53 and CHK1 stability.,2023,10.1038/s41418-023-01184-3,https://pubmed.ncbi.nlm.nih.gov/37353627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,34816637,Sex Comb on Midleg Like-2 Accelerates Hepatocellular Carcinoma Cell Proliferation and Metastasis by Activating Wnt/β-Catenin/EMT Signaling.,2021,10.3349/ymj.2021.62.12.1073,https://pubmed.ncbi.nlm.nih.gov/34816637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,41574544,Sex-specific mRNA and miRNA alterations in the allergic mite species Dermatophagoides farinae.,2026,10.1093/jme/tjaf185,https://pubmed.ncbi.nlm.nih.gov/41574544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,39267058,Whole exome sequencing analysis of 167 men with primary infertility.,2024,10.1186/s12920-024-02005-3,https://pubmed.ncbi.nlm.nih.gov/39267058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,31043422,Mammalian SWI/SNF collaborates with a polycomb-associated protein to regulate male germline transcription in the mouse.,2019,10.1242/dev.174094,https://pubmed.ncbi.nlm.nih.gov/31043422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,30097555,SCML2 promotes heterochromatin organization in late spermatogenesis.,2018,10.1242/jcs.217125,https://pubmed.ncbi.nlm.nih.gov/30097555/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,30137219,"A rapidly evolved domain, the SCML2 DNA-binding repeats, contributes to chromatin binding of mouse SCML2†.",2019,10.1093/biolre/ioy181,https://pubmed.ncbi.nlm.nih.gov/30137219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,32895557,Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition.,2020,10.1038/s41594-020-0488-3,https://pubmed.ncbi.nlm.nih.gov/32895557/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,25634095,Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis.,2015,10.1371/journal.pgen.1004954,https://pubmed.ncbi.nlm.nih.gov/25634095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,31630956,A Neofunctionalized X-Linked Ampliconic Gene Family Is Essential for Male Fertility and Equal Sex Ratio in Mice.,2019,10.1016/j.cub.2019.08.057,https://pubmed.ncbi.nlm.nih.gov/31630956/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,28810646,Sex comb on midleg like-2 is a novel specific marker for the diagnosis of gastroenteropancreatic neuroendocrine tumors.,2017,10.3892/etm.2017.4677,https://pubmed.ncbi.nlm.nih.gov/28810646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,29462142,RNF8 and SCML2 cooperate to regulate ubiquitination and H3K27 acetylation for escape gene activation on the sex chromosomes.,2018,10.1371/journal.pgen.1007233,https://pubmed.ncbi.nlm.nih.gov/29462142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,35530270,Construction of AP003469.4-miRNAs-mRNAs ceRNA network to reveal potential biomarkers for hepatocellular carcinoma.,2022,,https://pubmed.ncbi.nlm.nih.gov/35530270/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,24358021,Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.,2013,10.1371/journal.pbio.1001737,https://pubmed.ncbi.nlm.nih.gov/24358021/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SCML2,ENSG00000102098,Unsafe,10331946,"Identification of SCML2, a second human gene homologous to the Drosophila sex comb on midleg (Scm): A new gene cluster on Xp22.",1999,10.1006/geno.1999.5755,https://pubmed.ncbi.nlm.nih.gov/10331946/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,42733066,USP5 acts as a proteolytic switch to control SDE2 function via UBL-directed cleavage.,2026,10.1038/s41467-026-76751-6,https://pubmed.ncbi.nlm.nih.gov/42733066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,41666676,Inhibition of SDE2 promotes autophagy-dependent ferroptosis in multiple myeloma.,2026,10.1016/j.redox.2026.104007,https://pubmed.ncbi.nlm.nih.gov/41666676/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,42247766,Coordinated liver-serum-adipose lipid alterations and hepatic proteins regulate tissue-specific deposition of intramuscular and abdominal fat in chickens.,2026,10.1016/j.psj.2026.107209,https://pubmed.ncbi.nlm.nih.gov/42247766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,38558017,Interaction of ubiquitin-like protein SILENCING DEFECTIVE 2 with LIKE HETEROCHROMATIN PROTEIN 1 is required for regulation of anthocyanin biosynthesis in Arabidopsis thaliana in response to sucrose.,2024,10.1111/nph.19725,https://pubmed.ncbi.nlm.nih.gov/38558017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,41226651,Epigenetic Impact of Sleep Timing in Children: Novel DNA Methylation Signatures via SWAG Analysis.,2025,10.3390/ijms262110615,https://pubmed.ncbi.nlm.nih.gov/41226651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,40701931,Physical Exercise Improves Symptomatic Dermographism.,2025,10.1002/clt2.70083,https://pubmed.ncbi.nlm.nih.gov/40701931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,39273537,Transcriptomic Alterations in Spliceosome Components in Advanced Heart Failure: Status of Cardiac-Specific Alternative Splicing Factors.,2024,10.3390/ijms25179590,https://pubmed.ncbi.nlm.nih.gov/39273537/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,36095128,"Splicing of branchpoint-distant exons is promoted by Cactin, Tls1 and the ubiquitin-fold-activated Sde2.",2022,10.1093/nar/gkac769,https://pubmed.ncbi.nlm.nih.gov/36095128/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,35850305,Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks.,2022,10.1016/j.jbc.2022.102268,https://pubmed.ncbi.nlm.nih.gov/35850305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,34365507,SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing.,2021,10.1093/nar/gkab647,https://pubmed.ncbi.nlm.nih.gov/34365507/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,32743553,Proteome dynamics analysis identifies functional roles of SDE2 and hypoxia in DNA damage response in prostate cancer cells.,2020,10.1093/narcan/zcaa010,https://pubmed.ncbi.nlm.nih.gov/32743553/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,33127907,SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks.,2020,10.1038/s41467-020-19162-5,https://pubmed.ncbi.nlm.nih.gov/33127907/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,38925148,Mechanism for the initiation of spliceosome disassembly.,2024,10.1038/s41586-024-07741-1,https://pubmed.ncbi.nlm.nih.gov/38925148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,36659476,An ubiquitin-like protein SDE2 negatively affects sucrose-induced anthocyanin biosynthesis in Arabidopsis.,2017,10.1016/j.scib.2017.11.014,https://pubmed.ncbi.nlm.nih.gov/36659476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,33233764,Short Disordered Epitope of CRTAM Ig-Like V Domain as a Potential Target for Blocking Antibodies.,2020,10.3390/ijms21228798,https://pubmed.ncbi.nlm.nih.gov/33233764/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,28947618,Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.,2018,10.15252/embj.201796751,https://pubmed.ncbi.nlm.nih.gov/28947618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,30698750,Conditional degradation of SDE2 by the Arg/N-End rule pathway regulates stress response at replication forks.,2019,10.1093/nar/gkz054,https://pubmed.ncbi.nlm.nih.gov/30698750/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,33688234,Identification of Potential Early Diagnostic Biomarkers of Sepsis.,2021,10.2147/jir.s298604,https://pubmed.ncbi.nlm.nih.gov/33688234/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,27906959,PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress.,2016,10.1371/journal.pgen.1006465,https://pubmed.ncbi.nlm.nih.gov/27906959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,29680649,An initiator codon mutation in SDE2 causes recessive embryonic lethality in Holstein cattle.,2018,10.3168/jds.2017-14119,https://pubmed.ncbi.nlm.nih.gov/29680649/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,35509211,Immunotherapeutic Significance of a Prognostic Alternative Splicing Signature in Bladder Cancer.,2022,10.1177/15330338221090093,https://pubmed.ncbi.nlm.nih.gov/35509211/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,28534111,Overexpression of ppc or deletion of mdh for improving production of γ-aminobutyric acid in recombinant Corynebacterium glutamicum.,2017,10.1007/s11274-017-2289-3,https://pubmed.ncbi.nlm.nih.gov/28534111/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,30705154,A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.,2019,10.1126/science.aaw5569,https://pubmed.ncbi.nlm.nih.gov/30705154/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDE2,ENSG00000143751,Unsafe,29439392,The Uncertain Geographic Context Problem in the Analysis of the Relationships between Obesity and the Built Environment in Guangzhou.,2018,10.3390/ijerph15020308,https://pubmed.ncbi.nlm.nih.gov/29439392/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,42700237,FOXP1 exacerbates allergic rhinitis progression by mediating ferroptosis in nasal mucosal epithelial cells via transcriptional regulation of SDHAF2.,2026,10.1007/s00011-026-02333-3,https://pubmed.ncbi.nlm.nih.gov/42700237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,41544268,The LARGE1 controls grain size by repressing the interaction between PGL2 and APG in rice.,2026,10.1111/tpj.70674,https://pubmed.ncbi.nlm.nih.gov/41544268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,42626917,"Genetic, cellular, and environmental factors influencing tumourigenesis in carriers of succinate dehydrogenase germline mutations.",2026,10.1530/erc-26-0282,https://pubmed.ncbi.nlm.nih.gov/42626917/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,40815660,Complex II assembly drives metabolic adaptation to OXPHOS dysfunction.,2025,10.1126/sciadv.adr6012,https://pubmed.ncbi.nlm.nih.gov/40815660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,40079348,New Insights into the Clinical Characterization of SDHAF2-related Familial Paraganglioma Syndrome.,2025,10.1210/clinem/dgaf149,https://pubmed.ncbi.nlm.nih.gov/40079348/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,41907527,MsrB2 deficiency amplifies ECM-driven cardiac fibrosis under hypertensive stress.,2026,10.3389/fphys.2026.1772933,https://pubmed.ncbi.nlm.nih.gov/41907527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,41685087,Preliminary study of cyto-impedance: Molecular profiling of functional impedance in motility-promoting treatment of normal cells.,2026,10.1016/j.bbrep.2026.102476,https://pubmed.ncbi.nlm.nih.gov/41685087/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,39425877,Differential expression of nuclear-derived mitochondrial succinate dehydrogenase genes in metabolically active buffalo tissues.,2024,10.1007/s11033-024-10022-9,https://pubmed.ncbi.nlm.nih.gov/39425877/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,40615108,Short-term exposure to dim light at night affects reproduction and metabolism-linked processes in adult male tree sparrows (Passer montanus).,2025,10.1016/j.cbpa.2025.111902,https://pubmed.ncbi.nlm.nih.gov/40615108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,42666236,Complex landscape of somatic copy number alterations in head and neck paragangliomas.,2026,10.3389/fendo.2026.1841009,https://pubmed.ncbi.nlm.nih.gov/42666236/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,41915642,A novel genetic strategy to interrogate an unknown phenotypic modifier: Sdhc KO-Robertsonian mice develop frequent thyroid abnormalities with papillary thyroid carcinoma-like features.,2026,10.1371/journal.pone.0336731,https://pubmed.ncbi.nlm.nih.gov/41915642/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,38569044,Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria.,2024,10.1126/sciadv.adl0389,https://pubmed.ncbi.nlm.nih.gov/38569044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,40981001,Succinate dehydrogenase-related pheochromocytoma and paraganglioma (SDHx-PPGL): clinical and genetic insights from an Indian study.,2025,10.1530/ec-25-0500,https://pubmed.ncbi.nlm.nih.gov/40981001/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,38549682,SDHAF2-Linked Metastatic Paraganglioma: A Case Report with Implications for Counseling and Follow-Up of Pathogenic SDHAF2 Variant Carriers.,2024,10.1155/2024/2111531,https://pubmed.ncbi.nlm.nih.gov/38549682/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,41079773,Development of a CRISPR/Cas12a genome editing toolbox in &lt;i&gt;Kluyveromyces marxianus&lt;/i&gt; and its application in succinic acid biosynthesis.,2026,10.1016/j.synbio.2025.09.015,https://pubmed.ncbi.nlm.nih.gov/41079773/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,40685935,Metabolic Effects of Succinate Dehydrogenase Loss in Cancer.,2025,10.1002/jcp.70066,https://pubmed.ncbi.nlm.nih.gov/40685935/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,41169441,A Rare Case of Metastatic Carotid Body Paraganglioma: A 7-Year Asymptomatic Period.,2025,10.1155/crom/5565079,https://pubmed.ncbi.nlm.nih.gov/41169441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,36326104,SDH5 down-regulation mitigates the damage of osteoporosis via inhibiting the MyD88/NF-κB signaling pathway.,2023,10.1080/08923973.2022.2143372,https://pubmed.ncbi.nlm.nih.gov/36326104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,39586503,Succinate dehydrogenase mediated ROS production contributes to ASIC1a-induced chondrocyte pyroptosis in rheumatoid arthritis.,2025,10.1016/j.bbadis.2024.167585,https://pubmed.ncbi.nlm.nih.gov/39586503/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,34992822,Succinate dehydrogenase 5 regulates lung cancer metastasis by reprogramming glucose metabolism.,2021,10.21037/jtd-21-1769,https://pubmed.ncbi.nlm.nih.gov/34992822/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,31741753,PD-L1 regulation by SDH5 via β-catenin/ZEB1 signaling.,2019,10.1080/2162402x.2019.1655361,https://pubmed.ncbi.nlm.nih.gov/31741753/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,35741787,Hypothesis: Why Different Types of SDH Gene Variants Cause Divergent Tumor Phenotypes.,2022,10.3390/genes13061025,https://pubmed.ncbi.nlm.nih.gov/35741787/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,35158861,New Insights on the Genetics of Pheochromocytoma and Paraganglioma and Its Clinical Implications.,2022,10.3390/cancers14030594,https://pubmed.ncbi.nlm.nih.gov/35158861/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,36937957,Case report: Tisagenlecleucel for treatment of relapsed B- acute lymphoblastic leukemia in a patient with CHEK2 mutation.,2023,10.3389/fped.2023.1067131,https://pubmed.ncbi.nlm.nih.gov/36937957/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,36013579,"Novel Germline PHD2 Variant in a Metastatic Pheochromocytoma and Chronic Myeloid Leukemia, but in the Absence of Polycythemia.",2022,10.3390/medicina58081113,https://pubmed.ncbi.nlm.nih.gov/36013579/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,32246353,Orientation-dependent toxic effect of human papillomavirus type 33 long control region DNA in Escherichia coli cells.,2020,10.1007/s11262-020-01754-4,https://pubmed.ncbi.nlm.nih.gov/32246353/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,23983127,Succinate dehydrogenase 5 (SDH5) regulates glycogen synthase kinase 3β-β-catenin-mediated lung cancer metastasis.,2013,10.1074/jbc.m113.450106,https://pubmed.ncbi.nlm.nih.gov/23983127/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,33362715,Genetic and Clinical Profiles of Pheochromocytoma and Paraganglioma: A Single Center Study.,2020,10.3389/fendo.2020.574662,https://pubmed.ncbi.nlm.nih.gov/33362715/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,33560870,"Time Trends in Receipt of Germline Genetic Testing and Results for Women Diagnosed With Breast Cancer or Ovarian Cancer, 2012-2019.",2021,10.1200/jco.20.02785,https://pubmed.ncbi.nlm.nih.gov/33560870/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,32508744,"A Novel MAX Gene Mutation Variant in a Patient With Multiple and ""Composite"" Neuroendocrine-Neuroblastic Tumors.",2020,10.3389/fendo.2020.00234,https://pubmed.ncbi.nlm.nih.gov/32508744/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,28471419,Mitochondrial Deficiencies in the Predisposition to Paraganglioma.,2017,10.3390/metabo7020017,https://pubmed.ncbi.nlm.nih.gov/28471419/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,28332883,PRECISION MEDICINE: AN UPDATE ON GENOTYPE/BIOCHEMICAL PHENOTYPE RELATIONSHIPS IN PHEOCHROMOCYTOMA/PARAGANGLIOMA PATIENTS.,2017,10.4158/ep161718.ra,https://pubmed.ncbi.nlm.nih.gov/28332883/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDHAF2,ENSG00000167985,Unsafe,15689052,"Effects of d-003, a new substance purified from sugar cane wax, on platelet aggregation and plasma levels of arachidonic acid metabolites in healthy volunteers.",2004,,https://pubmed.ncbi.nlm.nih.gov/15689052/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,42085153,Single-cell multiomic and spatial landscape of the primate pineal gland reveals circadian and melatonin regulatory architecture.,2026,10.1073/pnas.2524839123,https://pubmed.ncbi.nlm.nih.gov/42085153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,42036012,Integrative analysis of lactylation patterns reveals prognostic biomarkers and therapeutic targets in pancreatic cancer.,2026,10.1016/j.canlet.2026.218536,https://pubmed.ncbi.nlm.nih.gov/42036012/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,41668247,Genome Sequencing in 19 Families With Bladder Exstrophy and Epispadias Complex Indicates Involvement of the ADGR -Gene Family.,2026,10.1002/ajmga.70074,https://pubmed.ncbi.nlm.nih.gov/41668247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,41692868,Laboratory and genetic characteristic associated with gallbladder-related outcomes in sickle cell disease in Brazil: results from the REDS-III multicenter cohort study.,2026,10.1007/s00277-026-06800-z,https://pubmed.ncbi.nlm.nih.gov/41692868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,39757246,Comparative transcriptome analysis identified genes involved in testicular development in Takifugu rubripes.,2025,10.1007/s10695-024-01439-x,https://pubmed.ncbi.nlm.nih.gov/39757246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,39442698,Methylome-wide association study of adolescent depressive episode with psychotic symptoms and childhood trauma.,2025,10.1016/j.jad.2024.10.029,https://pubmed.ncbi.nlm.nih.gov/39442698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,36580032,Identification of Novel Associations and Localization of Signals in Idiopathic Inflammatory Myopathies Using Genome-Wide Imputation.,2023,10.1002/art.42434,https://pubmed.ncbi.nlm.nih.gov/36580032/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,30687002,Expression and Roles of the Immunoglobulin Superfamily Recognition Molecule Sidekick1 in Mouse Retina.,2018,10.3389/fnmol.2018.00485,https://pubmed.ncbi.nlm.nih.gov/30687002/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,36273157,Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma.,2022,10.1186/s13046-022-02506-y,https://pubmed.ncbi.nlm.nih.gov/36273157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,32031713,Apocrine glands are bystanders in hidradenitis suppurativa and their involvement is gender specific.,2020,10.1111/jdv.16264,https://pubmed.ncbi.nlm.nih.gov/32031713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,32982686,Structure and Functions of Sidekicks.,2020,10.3389/fnmol.2020.00139,https://pubmed.ncbi.nlm.nih.gov/32982686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,30078982,Expression patterns of dscam and sdk gene paralogs in developing zebrafish retina.,2018,,https://pubmed.ncbi.nlm.nih.gov/30078982/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,26287463,Sidekick 2 directs formation of a retinal circuit that detects differential motion.,2015,10.1038/nature14682,https://pubmed.ncbi.nlm.nih.gov/26287463/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,34173924,Immunogenomic profiling and pathological response results from a clinical trial of docetaxel and carboplatin in triple-negative breast cancer.,2021,10.1007/s10549-021-06307-3,https://pubmed.ncbi.nlm.nih.gov/34173924/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,27644106,Molecular basis of sidekick-mediated cell-cell adhesion and specificity.,2016,10.7554/elife.19058,https://pubmed.ncbi.nlm.nih.gov/27644106/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,33145279,Genetic polymorphisms in neuroendocrine disorder-related candidate genes associated with pre-pregnancy obesity in gestational diabetes mellitus patients by using a stratification approach.,2020,10.21037/atm-20-1579,https://pubmed.ncbi.nlm.nih.gov/33145279/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,23055510,Expanding the Ig superfamily code for laminar specificity in retina: expression and role of contactins.,2012,10.1523/jneurosci.3193-12.2012,https://pubmed.ncbi.nlm.nih.gov/23055510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,20046828,Disease gene characterization through large-scale co-expression analysis.,2009,10.1371/journal.pone.0008491,https://pubmed.ncbi.nlm.nih.gov/20046828/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,17540029,NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation.,2007,10.1186/1471-2164-8-139,https://pubmed.ncbi.nlm.nih.gov/17540029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SDK2,ENSG00000069188,Unsafe,15551339,Congenital stationary night blindness: report of an autosomal recessive family and linkage analysis.,2005,10.1002/ajmg.a.30372,https://pubmed.ncbi.nlm.nih.gov/15551339/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,40907915,"The advanced role of the transcription factor RGPR-p117 in cell regulation: Its involvement in transcription, cell growth, and lipid metabolism.",2025,10.1016/j.ijbiomac.2025.147359,https://pubmed.ncbi.nlm.nih.gov/40907915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,42454484,SEC16B identified as a regulator of VLDL secretion and lipid accumulation in the liver.,2026,10.1172/jci208521,https://pubmed.ncbi.nlm.nih.gov/42454484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,42032080,Tissue-selective COPII modulator SEC16B aggravates cardiovascular disease by promoting lipid export.,2026,10.1038/s44318-026-00754-8,https://pubmed.ncbi.nlm.nih.gov/42032080/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,42464700,Possibility to therapeutically exploit RGPR-p117 as a target in cancer cells.,2026,10.1080/14728222.2026.2706466,https://pubmed.ncbi.nlm.nih.gov/42464700/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,42030462,Hepatic SEC16B regulates lipid homeostasis by coordinating VLDL secretion and lipid droplet expansion.,2026,10.1172/jci204602,https://pubmed.ncbi.nlm.nih.gov/42030462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,42526727,Identification and functional characterisation of the relaxin-like gonad-stimulating peptide receptor in sea cucumbers.,2026,10.1016/j.ygcen.2026.114987,https://pubmed.ncbi.nlm.nih.gov/42526727/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,42022796,Genetic architecture of obesity and advances in precision pharmacotherapy: a comprehensive review.,2026,10.3389/abp.2026.15484,https://pubmed.ncbi.nlm.nih.gov/42022796/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,40735296,Single-Cell RNA Sequencing Reveals the Critical Role of SEC16B in Lung Metastasis of Osteosarcoma.,2025,10.1096/fba.2024-00161,https://pubmed.ncbi.nlm.nih.gov/40735296/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,35835253,The overexpressed transcription factor RGPR-p117 suppresses the proliferation of normal rat kidney proximal tubular epithelial NRK-52E cells: Involvement of diverse signaling pathways.,2022,10.1016/j.lfs.2022.120795,https://pubmed.ncbi.nlm.nih.gov/35835253/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,39780531,Overexpression of RGPR-p117 reveals anticancer effects by regulating multiple signaling pathways in bone metastatic human breast cancer MDA-MB-231 cells.,2025,10.1002/iub.2939,https://pubmed.ncbi.nlm.nih.gov/39780531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,40939325,Integrative multi-omics analysis reveals key regulatory nodes of abdominal fat deposition in broiler chickens.,2025,10.1016/j.psj.2025.105802,https://pubmed.ncbi.nlm.nih.gov/40939325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,39584991,Ocular Mucous Membrane Pemphigoid Demonstrates a Distinct Autoantibody Profile from Those of Other Autoimmune Blistering Diseases: A Preliminary Study.,2024,10.3390/antib13040091,https://pubmed.ncbi.nlm.nih.gov/39584991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,36916446,Bi-allelic mutation in SEC16B alters collagen trafficking and increases ER stress.,2023,10.15252/emmm.202216834,https://pubmed.ncbi.nlm.nih.gov/36916446/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,36796587,Intestinal SEC16B modulates obesity by regulating chylomicron metabolism.,2023,10.1016/j.molmet.2023.101693,https://pubmed.ncbi.nlm.nih.gov/36796587/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,28413634,"Involvement of regucalcin gene promoter region-related protein-p117, a transcription factor, in human obesity.",2017,10.3892/br.2017.874,https://pubmed.ncbi.nlm.nih.gov/28413634/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,36445968,Impaired glutamylation of RPGRORF15 underlies the cone-dominated phenotype associated with truncating distal ORF15 variants.,2022,10.1073/pnas.2208707119,https://pubmed.ncbi.nlm.nih.gov/36445968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,33958541,Female-Specific Susceptibility Locus in BOC and SEC16B are Associated with Adolescent Idiopathic Scoliosis.,2021,10.1097/brs.0000000000004098,https://pubmed.ncbi.nlm.nih.gov/33958541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,38604958,"[Association of polymorphisms in SEC16B, DNAJC27, FTO and MC4R genes with overweight and obesity in Han preschool children].",2024,10.19813/j.cnki.weishengyanjiu.2024.02.009,https://pubmed.ncbi.nlm.nih.gov/38604958/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,41000562,Pharmacogenomics of the Etonogestrel Contraceptive Implant: A Genome-Wide Association Study of Steady-State Etonogestrel Concentrations.,2025,10.1097/og9.0000000000000066,https://pubmed.ncbi.nlm.nih.gov/41000562/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,38246519,Regucalcin downregulation in human cancer.,2024,10.1016/j.lfs.2024.122448,https://pubmed.ncbi.nlm.nih.gov/38246519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,35712653,The Pyroptosis-Related Long Noncoding RNA Signature Predicts Prognosis and Indicates Immunotherapeutic Efficiency in Hepatocellular Carcinoma.,2022,10.3389/fcell.2022.779269,https://pubmed.ncbi.nlm.nih.gov/35712653/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,36839421,Association of Plant-Based and High-Protein Diets with a Lower Obesity Risk Defined by Fat Mass in Middle-Aged and Elderly Persons with a High Genetic Risk of Obesity.,2023,10.3390/nu15041063,https://pubmed.ncbi.nlm.nih.gov/36839421/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,33801339,Association between Single Nucleotide Polymorphisms and Weight Reduction in Behavioural Interventions-A Pooled Analysis.,2021,10.3390/nu13030819,https://pubmed.ncbi.nlm.nih.gov/33801339/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,29436922,Breast cancer family history and allele-specific DNA methylation in the legacy girls study.,2018,10.1080/15592294.2018.1435243,https://pubmed.ncbi.nlm.nih.gov/29436922/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,23838847,Superparamagnetic iron oxide nanoparticles alter expression of obesity and T2D-associated risk genes in human adipocytes.,2013,10.1038/srep02173,https://pubmed.ncbi.nlm.nih.gov/23838847/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,31504550,A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity.,2019,10.1093/hmg/ddz161,https://pubmed.ncbi.nlm.nih.gov/31504550/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,23669352,Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.,2013,10.1093/hmg/ddt205,https://pubmed.ncbi.nlm.nih.gov/23669352/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,21773002,Mendelian Randomisation Study of Childhood BMI and Early Menarche.,2011,10.1155/2011/180729,https://pubmed.ncbi.nlm.nih.gov/21773002/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,23935507,"Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry.",2013,10.1371/journal.pgen.1003607,https://pubmed.ncbi.nlm.nih.gov/23935507/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,21912638,Studies of metabolic phenotypic correlates of 15 obesity associated gene variants.,2011,10.1371/journal.pone.0023531,https://pubmed.ncbi.nlm.nih.gov/21912638/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,17192411,Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization.,2007,10.1091/mbc.e06-08-0707,https://pubmed.ncbi.nlm.nih.gov/17192411/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEC16B,ENSG00000120341,Unsafe,12244571,Gene expression for a novel protein RGPR-p117 in various species: the stimulation by intracellular signaling factors.,2002,10.1002/jcb.10289,https://pubmed.ncbi.nlm.nih.gov/12244571/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,41383972,SENP5 acts as a downstream target of androgen receptor and contributes to prostate cancer growth.,2026,10.3892/ol.2025.15404,https://pubmed.ncbi.nlm.nih.gov/41383972/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,42015005,Driver or passenger? A new assessment of genes in the schizophrenia-associated 3q29 deletion locus for contribution to neurodevelopmental disorders.,2026,10.1186/s11689-026-09696-y,https://pubmed.ncbi.nlm.nih.gov/42015005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,41268439,SUMOylation involved in malignant progression of multiple tumors and SENP5 may improve the chemotherapy sensitivity of hypoxic tumors.,2025,10.3389/fphar.2025.1648271,https://pubmed.ncbi.nlm.nih.gov/41268439/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,40474290,SENP5 drives breast cancer progression through deSUMOYlation of CDK1.,2025,10.1186/s13058-025-02054-1,https://pubmed.ncbi.nlm.nih.gov/40474290/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,42410730,Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.,2026,10.1002/alz.71630,https://pubmed.ncbi.nlm.nih.gov/42410730/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,41827042,SENP5 enhances antiviral innate immunity by promoting AURKA-dependent STAT2 phosphorylation.,2026,10.1186/s12964-026-02808-0,https://pubmed.ncbi.nlm.nih.gov/41827042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,41198555,SENP5 Attenuates LPS-Induced Acute Lung Injury by Inhibiting Apoptosis of Lung Epithelial Cells Through SLC7A5/mTOR Signaling Pathway.,2025,10.31083/fbl45811,https://pubmed.ncbi.nlm.nih.gov/41198555/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,40404649,Structural basis for the human SENP5's SUMO isoform discrimination.,2025,10.1038/s41467-025-60029-4,https://pubmed.ncbi.nlm.nih.gov/40404649/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,40410883,SENP5 promotes endometrial cancer cell growth by regulating β-catenin deSUMOylation to enhance GPX4-resistance to ferroptosis.,2025,10.1186/s40001-025-02662-9,https://pubmed.ncbi.nlm.nih.gov/40410883/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,40358846,Integrative analysis of the expression profile and prognostic values of SENP gene family in hepatocellular carcinoma.,2025,10.1007/s12672-025-02598-w,https://pubmed.ncbi.nlm.nih.gov/40358846/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,42157158,Integrative interpretable learning reveals shared patterns of epitranscriptomic regulation across multiple cancer types.,2026,10.1186/s12915-026-02628-1,https://pubmed.ncbi.nlm.nih.gov/42157158/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,39862098,SUMO-Specific Peptidase 5 Promotes Oesophageal Squamous Cell Carcinoma Growth through the NF-κB-&lt;i&gt;SLC1A3&lt;/i&gt; Axis.,2025,10.31083/fbl27047,https://pubmed.ncbi.nlm.nih.gov/39862098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,38712596,Inhibition of SENP5 reduces brain injury in TBI rats by regulating NEDD4L/TCF3 axis.,2024,10.1080/00207454.2024.2350669,https://pubmed.ncbi.nlm.nih.gov/38712596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,39433793,Peptidylprolyl isomerase A guides SENP5/GAU1 DNA-lncRNA triplex generation for driving tumorigenesis.,2024,10.1038/s41467-024-53493-x,https://pubmed.ncbi.nlm.nih.gov/39433793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,37684630,SENP5 promotes homologous recombination-mediated DNA damage repair in colorectal cancer cells through H2AZ deSUMOylation.,2023,10.1186/s13046-023-02789-9,https://pubmed.ncbi.nlm.nih.gov/37684630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,37403456,SENP5 deteriorates traumatic brain injury via SUMO2-dependent suppression of E2F1 SUMOylation.,2023,10.3724/abbs.2023121,https://pubmed.ncbi.nlm.nih.gov/37403456/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,41761142,UHRF2 related to sumoylation : assessment of its role in immune suppression and therapeutic potential in colorectal cancer.,2026,10.1186/s12885-026-15727-7,https://pubmed.ncbi.nlm.nih.gov/41761142/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,38615367,Astragaloside IV combined with ligustrazine ameliorates abnormal mitochondrial dynamics via Drp1 SUMO/deSUMOylation in cerebral ischemia-reperfusion injury.,2024,10.1111/cns.14725,https://pubmed.ncbi.nlm.nih.gov/38615367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,40796734,The mitochondrial E3 ligase MAPL SUMOylates Drp1 to facilitate mitochondrial fission in intervertebral disc degeneration.,2025,10.1038/s41413-025-00449-6,https://pubmed.ncbi.nlm.nih.gov/40796734/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,38065954,Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis.,2023,10.1038/s41467-023-43751-9,https://pubmed.ncbi.nlm.nih.gov/38065954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,32859637,Platinum Drug Sensitivity Polymorphisms in Stage III Non-small Cell Lung Cancer With Invasion of Mediastinal Lymph Nodes.,2020,10.21873/cgp.20215,https://pubmed.ncbi.nlm.nih.gov/32859637/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,36834565,Biomarkers in the Rat Hippocampus and Peripheral Blood for an Early Stage of Mental Disorders Induced by Water Immersion Stress.,2023,10.3390/ijms24043153,https://pubmed.ncbi.nlm.nih.gov/36834565/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,34869605,SUMO-specific Isopeptidases Tuning Cardiac SUMOylation in Health and Disease.,2021,10.3389/fmolb.2021.786136,https://pubmed.ncbi.nlm.nih.gov/34869605/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,34695034,Specific Plasma MicroRNA Signatures in Predicting and Confirming Crohn's Disease Recurrence: Role and Pathogenic Implications.,2021,10.14309/ctg.0000000000000416,https://pubmed.ncbi.nlm.nih.gov/34695034/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,27543010,"Integrated analysis of miRNA and mRNA gene expression microarrays: Influence on platelet reactivity, clopidogrel response and drug-induced toxicity.",2016,10.1016/j.gene.2016.08.028,https://pubmed.ncbi.nlm.nih.gov/27543010/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,29311920,Modulation of miR-26a-5p and miR-15b-5p Exosomal Expression Associated with Clopidogrel-Induced Hepatotoxicity in HepG2 Cells.,2017,10.3389/fphar.2017.00906,https://pubmed.ncbi.nlm.nih.gov/29311920/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP5,ENSG00000119231,Unsafe,31324747,Genome-Wide Association Analysis for Resistance to Infectious Pancreatic Necrosis Virus Identifies Candidate Genes Involved in Viral Replication and Immune Response in Rainbow Trout (Oncorhynchus mykiss).,2019,10.1534/g3.119.400463,https://pubmed.ncbi.nlm.nih.gov/31324747/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,42452912,A Noncanonical Protein Degradation Pathway That Regulates Germ Cell Maintenance.,2026,10.1111/cpr.70259,https://pubmed.ncbi.nlm.nih.gov/42452912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,41385186,"NEDD8, stress granules, and amyotrophic lateral sclerosis: unveiling the therapeutic potential of the NEDP1 protease.",2025,10.1042/ebc20253036,https://pubmed.ncbi.nlm.nih.gov/41385186/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,41236496,NEDD8-specific protease 1 deficiency as a novel driver of hepatoblastoma development through dysregulation of the CAND1-NEDD8 pathway.,2025,10.1097/hep.0000000000001614,https://pubmed.ncbi.nlm.nih.gov/41236496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,39149589,"Authentication and validation of key genes in the treatment of atopic dermatitis with Runfuzhiyang powder: combined RNA-seq, bioinformatics analysis, and experimental research.",2024,10.3389/fgene.2024.1335093,https://pubmed.ncbi.nlm.nih.gov/39149589/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,38314144,Etoposide-induced SENP8 confers a feed-back drug resistance on acute lymphoblastic leukemia cells.,2024,10.1016/j.bbrep.2024.101650,https://pubmed.ncbi.nlm.nih.gov/38314144/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,36669387,NFIC attenuates rheumatoid arthritis-induced inflammatory response in mice by regulating PTEN/SENP8 transcription.,2023,10.1016/j.tice.2023.102013,https://pubmed.ncbi.nlm.nih.gov/36669387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,37000881,Targeting the NEDP1 enzyme to ameliorate ALS phenotypes through stress granule disassembly.,2023,10.1126/sciadv.abq7585,https://pubmed.ncbi.nlm.nih.gov/37000881/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,36847487,Deneddylating enzyme SENP8 regulates neuronal development.,2023,10.1111/jnc.15797,https://pubmed.ncbi.nlm.nih.gov/36847487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,37325561,The long non-coding RNA MALAT1 regulates intestine host-microbe interactions and polyposis.,2023,10.3389/fcell.2023.1168693,https://pubmed.ncbi.nlm.nih.gov/37325561/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,36626230,SHP2 deneddylation mediates tumor immunosuppression in colon cancer via the CD47/SIRPα axis.,2023,10.1172/jci162870,https://pubmed.ncbi.nlm.nih.gov/36626230/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,31301771,Adenovirus oncoprotein E4orf6 triggers Cullin5 neddylation to activate the CLR5 E3 ligase for p53 degradation.,2019,10.1016/j.bbrc.2019.07.028,https://pubmed.ncbi.nlm.nih.gov/31301771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,28475037,SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function.,2017,10.7554/elife.24325,https://pubmed.ncbi.nlm.nih.gov/28475037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,31577950,The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity.,2019,10.1016/j.celrep.2019.08.070,https://pubmed.ncbi.nlm.nih.gov/31577950/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,39253816,A Modular Biosensor Design for Quantitative Measurement of Free Nedd8.,2024,10.1021/acssensors.4c01130,https://pubmed.ncbi.nlm.nih.gov/39253816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,32779270,Neddylation modification of ribosomal protein RPS27L or RPS27 by MDM2 or NEDP1 regulates cancer cell survival.,2020,10.1096/fj.202000530rrr,https://pubmed.ncbi.nlm.nih.gov/32779270/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,33299139,Neddylation of PTEN regulates its nuclear import and promotes tumor development.,2021,10.1038/s41422-020-00443-z,https://pubmed.ncbi.nlm.nih.gov/33299139/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,34662580,Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis.,2021,10.1016/j.jbc.2021.101307,https://pubmed.ncbi.nlm.nih.gov/34662580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,28831681,NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase η in response to oxidative DNA damage.,2018,10.1007/s13238-017-0455-x,https://pubmed.ncbi.nlm.nih.gov/28831681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,33996822,The Absence of PTEN in Breast Cancer Is a Driver of MLN4924 Resistance.,2021,10.3389/fcell.2021.667435,https://pubmed.ncbi.nlm.nih.gov/33996822/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,31300418,Genome-wide CRISPR screens reveal genetic mediators of cereblon modulator toxicity in primary effusion lymphoma.,2019,10.1182/bloodadvances.2019031732,https://pubmed.ncbi.nlm.nih.gov/31300418/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,42401166,Aloin suppresses cancer cell growth via autophagy-promoted NEDD8 de-NEDDylation to target GPX4 for ferroptosis induction.,2026,10.1016/j.bioorg.2026.110201,https://pubmed.ncbi.nlm.nih.gov/42401166/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,28281864,Vaccines licensed and in clinical trials for the prevention of dengue.,2017,10.1080/21645515.2016.1261770,https://pubmed.ncbi.nlm.nih.gov/28281864/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,26458804,Preclinical and clinical development of a dengue recombinant subunit vaccine.,2015,10.1016/j.vaccine.2015.09.101,https://pubmed.ncbi.nlm.nih.gov/26458804/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,26335452,Development of a capillary zone electrophoresis method for dose determination in a tetravalent dengue vaccine candidate.,2015,10.1002/elps.201500186,https://pubmed.ncbi.nlm.nih.gov/26335452/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,31253823,Cross-serotype interactions and disease outcome prediction of dengue infections in Vietnam.,2019,10.1038/s41598-019-45816-6,https://pubmed.ncbi.nlm.nih.gov/31253823/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,26403403,PAPILLARY THYROID CANCER IS CHARACTERIZED BY ALTERED EXPRESSION OF GENES INVOLVED IN THE SUMOYLATION PROCESS.,2015,,https://pubmed.ncbi.nlm.nih.gov/26403403/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,17328799,Vaccine candidates for dengue virus type 1 (DEN1) generated by replacement of the structural genes of rDEN4 and rDEN4Delta30 with those of DEN1.,2007,10.1186/1743-422x-4-23,https://pubmed.ncbi.nlm.nih.gov/17328799/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,26561315,"A cohesive analysis of DNA/RNA sequences via entropy, energetics and spectral-domain methods to assess genomic features across single viral diversity.",2015,10.1504/ijbra.2015.070113,https://pubmed.ncbi.nlm.nih.gov/26561315/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,17012875,The live attenuated dengue serotype 1 vaccine rDEN1Delta30 is safe and highly immunogenic in healthy adult volunteers.,2006,10.4161/hv.2.4.2944,https://pubmed.ncbi.nlm.nih.gov/17012875/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,27682585,Perturbation of neddylation-dependent NF-κB responses in the intestinal epithelium drives apoptosis and inhibits resolution of mucosal inflammation.,2016,10.1091/mbc.e16-05-0273,https://pubmed.ncbi.nlm.nih.gov/27682585/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,26144900,Preclinical development of a dengue tetravalent recombinant subunit vaccine: Immunogenicity and protective efficacy in nonhuman primates.,2015,10.1016/j.vaccine.2015.06.067,https://pubmed.ncbi.nlm.nih.gov/26144900/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,17426182,Induction of bivalent immune responses by expression of dengue virus type 1 and type 2 antigens from a single complex adenoviral vector.,2007,10.4269/ajtmh.2007.76.743,https://pubmed.ncbi.nlm.nih.gov/17426182/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,11462001,"Construction, safety, and immunogenicity in nonhuman primates of a chimeric yellow fever-dengue virus tetravalent vaccine.",2001,10.1128/jvi.75.16.7290-7304.2001,https://pubmed.ncbi.nlm.nih.gov/11462001/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,12693596,Chimeric dengue type 2/type 1 viruses induce immune responses in cynomolgus monkeys.,2002,,https://pubmed.ncbi.nlm.nih.gov/12693596/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,20042502,Serotype-specific structural differences in the protease-cofactor complexes of the dengue virus family.,2010,10.1128/jvi.02044-09,https://pubmed.ncbi.nlm.nih.gov/20042502/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SENP8,ENSG00000166192,Unsafe,12730221,"NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins.",2003,10.1074/jbc.m212948200,https://pubmed.ncbi.nlm.nih.gov/12730221/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,42603098,"Disease characteristics of SEPSECS deficiency: An international, retrospective, multicenter cohort study.",2026,10.1016/j.gim.2026.102684,https://pubmed.ncbi.nlm.nih.gov/42603098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,42398735,Mapping of class II HLA restriction of SepSecS-specific CD4 T-cell epitopes in autoimmune hepatitis.,2026,10.1016/j.jhepr.2026.101952,https://pubmed.ncbi.nlm.nih.gov/42398735/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,39817450,Clonal analysis of SepSecS-specific B and T cells in autoimmune hepatitis.,2025,10.1172/jci183776,https://pubmed.ncbi.nlm.nih.gov/39817450/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,40017499,Acute neurological regression following fever as presenting sign of pontocerebellar hypoplasia type 2D (SEPSECS mutation).,2025,10.3892/br.2025.1945,https://pubmed.ncbi.nlm.nih.gov/40017499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,40618995,"Functional characterization of promoter regions in selenoprotein synthesis-relevant genes (sbp2, eefsec and sepsecs) and their selenium-dependent regulation in yellow catfish Pelteobagrus fulvidraco.",2025,10.1016/j.bbagrm.2025.195105,https://pubmed.ncbi.nlm.nih.gov/40618995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,39817449,Elucidating the role of autoreactive T cells and B cells in autoimmune hepatitis.,2025,10.1172/jci188538,https://pubmed.ncbi.nlm.nih.gov/39817449/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,39385655,"Human selenocysteine synthase, SEPSECS, has evolved to optimize binding of a tRNA-based substrate.",2024,10.1093/nar/gkae875,https://pubmed.ncbi.nlm.nih.gov/39385655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,37761892,Integrative Analysis Unveils the Correlation of Aminoacyl-tRNA Biosynthesis Metabolites with the Methylation of the SEPSECS Gene in Huntington's Disease Brain Tissue.,2023,10.3390/genes14091752,https://pubmed.ncbi.nlm.nih.gov/37761892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,41825724,Genetic and clinical insights into pontocerebellar hypoplasia: Identification of novel variants in an Iranian cohort.,2026,10.1016/j.ejmg.2026.105074,https://pubmed.ncbi.nlm.nih.gov/41825724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,34884733,Human Genetic Disorders Resulting in Systemic Selenoprotein Deficiency.,2021,10.3390/ijms222312927,https://pubmed.ncbi.nlm.nih.gov/34884733/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,34794077,Missense mutation in selenocysteine synthase causes cardio-respiratory failure and perinatal death in mice which can be compensated by selenium-independent GPX4.,2021,10.1016/j.redox.2021.102188,https://pubmed.ncbi.nlm.nih.gov/34794077/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,35155316,Case Report: A Relatively Mild Phenotype Produced by Novel Mutations in the SEPSECS Gene.,2021,10.3389/fped.2021.805575,https://pubmed.ncbi.nlm.nih.gov/35155316/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,40464295,Gene-Environment Interactions in Inflammatory Bowel Disease: A Systematic Review of Human Epidemiologic Studies.,2025,10.1093/ecco-jcc/jjaf061,https://pubmed.ncbi.nlm.nih.gov/40464295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,36929010,Structural basis for the tRNA-dependent activation of the terminal complex of selenocysteine synthesis in humans.,2023,10.1093/nar/gkad182,https://pubmed.ncbi.nlm.nih.gov/36929010/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,32295391,Human Disorders Affecting the Selenocysteine Incorporation Pathway Cause Systemic Selenoprotein Deficiency.,2020,10.1089/ars.2020.8097,https://pubmed.ncbi.nlm.nih.gov/32295391/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,36952494,Integrative identification of hub genes in development of atrial fibrillation related stroke.,2023,10.1371/journal.pone.0283617,https://pubmed.ncbi.nlm.nih.gov/36952494/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,40394511,Identification of regulatory loci and candidate genes related to body weight traits in broilers based on different models.,2025,10.1186/s12864-025-11651-5,https://pubmed.ncbi.nlm.nih.gov/40394511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,35252561,Novel SEPSECS Pathogenic Variants Featuring Unusual Phenotype of Complex Movement Disorder With Thin Corpus Callosum: A Case Report.,2022,10.1212/nxg.0000000000000661,https://pubmed.ncbi.nlm.nih.gov/35252561/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,38347586,Broadening the phenotype and genotype spectrum of novel mutations in pontocerebellar hypoplasia with a comprehensive molecular literature review.,2024,10.1186/s12920-024-01810-0,https://pubmed.ncbi.nlm.nih.gov/38347586/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,37202783,Development and validation of a selenium metabolism regulators associated prognostic model for hepatocellular carcinoma.,2023,10.1186/s12885-023-10944-w,https://pubmed.ncbi.nlm.nih.gov/37202783/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,36895935,A novel cuproptosis-related lncRNA signature to predict prognosis and immune landscape of lung adenocarcinoma.,2023,10.21037/tlcr-22-500,https://pubmed.ncbi.nlm.nih.gov/36895935/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,39067134,A susceptibility gene signature for ERBB2-driven mammary tumour development and metastasis in collaborative cross mice.,2024,10.1016/j.ebiom.2024.105260,https://pubmed.ncbi.nlm.nih.gov/39067134/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,34482353,"Candidate host epigenetic marks predictive for HIV reservoir size, responsiveness to latency reversal, and viral rebound.",2021,10.1097/qad.0000000000003065,https://pubmed.ncbi.nlm.nih.gov/34482353/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,36879187,Establishment of a prognostic signature for lung adenocarcinoma using cuproptosis-related lncRNAs.,2023,10.1186/s12859-023-05192-5,https://pubmed.ncbi.nlm.nih.gov/36879187/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,30815697,Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity.,2019,10.1093/toxsci/kfz024,https://pubmed.ncbi.nlm.nih.gov/30815697/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,27576344,Structural basis for early-onset neurological disorders caused by mutations in human selenocysteine synthase.,2016,10.1038/srep32563,https://pubmed.ncbi.nlm.nih.gov/27576344/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,31685647,TNF-Producing Th1 Cells Are Selectively Expanded in Liver Infiltrates of Patients with Autoimmune Hepatitis.,2019,10.4049/jimmunol.1900124,https://pubmed.ncbi.nlm.nih.gov/31685647/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,33224150,Hepatic-Specific Decrease in the Expression of Selenoenzymes and Factors Essential for Selenium Processing After Endotoxemia.,2020,10.3389/fimmu.2020.595282,https://pubmed.ncbi.nlm.nih.gov/33224150/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,20623998,Human SepSecS or SLA/LP: selenocysteine formation and autoimmune hepatitis.,2010,10.1515/bc.2010.078,https://pubmed.ncbi.nlm.nih.gov/20623998/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,26282526,Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels.,2016,10.1007/s12011-015-0470-9,https://pubmed.ncbi.nlm.nih.gov/26282526/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,24599700,Cerebellar hypoplasia in mice lacking selenoprotein biosynthesis in neurons.,2014,10.1007/s12011-014-9920-z,https://pubmed.ncbi.nlm.nih.gov/24599700/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,23112913,"Selenium, selenoprotein genes and Crohn's disease in a case-control population from Auckland, New Zealand.",2012,10.3390/nu4091247,https://pubmed.ncbi.nlm.nih.gov/23112913/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPSECS,ENSG00000109618,Unsafe,23514769,Gene expression of endoplasmic reticulum resident selenoproteins correlates with apoptosis in various muscles of se-deficient chicks.,2013,10.3945/jn.112.172395,https://pubmed.ncbi.nlm.nih.gov/23514769/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,41927050,Functional characterization of porcine septin12 and its role in male reproduction.,2026,10.5713/ab.250538,https://pubmed.ncbi.nlm.nih.gov/41927050/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,39850804,"A novel SEPT12 mutation, T96I, is associated with sperm head and annulus defects.",2024,10.3389/fcell.2024.1498013,https://pubmed.ncbi.nlm.nih.gov/39850804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,42203511,Annulus fracture underlies radiation-induced sperm dysfunction revealed by multimodal nano-imaging.,2026,10.26508/lsa.202603693,https://pubmed.ncbi.nlm.nih.gov/42203511/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,39672481,Sept10 and sept12 are expressed in specific proliferating cells in zebrafish brain.,2025,10.1016/j.gep.2024.119387,https://pubmed.ncbi.nlm.nih.gov/39672481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,40783874,[SEPT12 in male infertility: Advances in studies].,2024,,https://pubmed.ncbi.nlm.nih.gov/40783874/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,38870534,SUN5 interacts with nuclear membrane LaminB1 and cytoskeletal GTPase Septin12 mediating the sperm head-and-tail junction.,2024,10.1093/molehr/gaae022,https://pubmed.ncbi.nlm.nih.gov/38870534/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,41376943,A retrospective study with whole-exome sequencing of tissue samples: analysis of risk factors in patients of persistent cough following lung segmentectomy.,2025,10.21037/jtd-2025-1061,https://pubmed.ncbi.nlm.nih.gov/41376943/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,41126076,Genome loci with selection signatures revealed in a domesticated mandarin fish population.,2025,10.1186/s12864-025-12145-0,https://pubmed.ncbi.nlm.nih.gov/41126076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,35547809,"Homozygous Loss of Septin12, but not its Haploinsufficiency, Leads to Male Infertility and Fertilization Failure.",2022,10.3389/fcell.2022.850052,https://pubmed.ncbi.nlm.nih.gov/35547809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,41566415,Integrating reaction norm models and genome-wide association analyses to reveal the genetic architecture and environmental sensitivity of sexual precocity in Nellore cattle.,2026,10.1186/s12864-026-12547-8,https://pubmed.ncbi.nlm.nih.gov/41566415/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,30189608,CDC42 Negatively Regulates Testis-Specific SEPT12 Polymerization.,2018,10.3390/ijms19092627,https://pubmed.ncbi.nlm.nih.gov/30189608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,40376536,Establishment and clinical significance of genetic factor screening method for patients with nonobstructive azoospermia based on whole exon sequencing technology.,2025,10.21037/tau-2024-676,https://pubmed.ncbi.nlm.nih.gov/40376536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,30513371,Identification of SEPTIN12 as a novel target of the androgen and estrogen receptors in human testicular cells.,2019,10.1016/j.biochi.2018.11.018,https://pubmed.ncbi.nlm.nih.gov/30513371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,36715674,Proper phosphorylation of septin 12 regulates septin 4 and soluble adenylyl cyclase expression to induce sperm capacitation.,2023,10.1002/jcp.30951,https://pubmed.ncbi.nlm.nih.gov/36715674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,37459509,In vivo versus in silico assessment of potentially pathogenic missense variants in human reproductive genes.,2023,10.1073/pnas.2219925120,https://pubmed.ncbi.nlm.nih.gov/37459509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,34057684,SEPTIN12 c.474 G &gt; A polymorphism as a risk factor in teratozoospermic patients.,2021,10.1007/s11033-021-06417-7,https://pubmed.ncbi.nlm.nih.gov/34057684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,37935322,Identification of a potential signature to predict the risk of postmenopausal osteoporosis.,2024,10.1016/j.gene.2023.147942,https://pubmed.ncbi.nlm.nih.gov/37935322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,31880374,Single-nucleotide polymorphism c.474G>A in the SEPT12 gene is a predisposing factor in male infertility.,2020,10.1002/mrd.23310,https://pubmed.ncbi.nlm.nih.gov/31880374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,24213608,SEPT12-microtubule complexes are required for sperm head and tail formation.,2013,10.3390/ijms141122102,https://pubmed.ncbi.nlm.nih.gov/24213608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,38664359,Evaluation of an Updated Gene Panel as a Diagnostic Tool for Both Male and Female Infertility.,2024,10.1007/s43032-024-01553-4,https://pubmed.ncbi.nlm.nih.gov/38664359/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,34791246,Whole-exome sequencing of a cohort of infertile men reveals novel causative genes in teratozoospermia that are chiefly related to sperm head defects.,2021,10.1093/humrep/deab229,https://pubmed.ncbi.nlm.nih.gov/34791246/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,17967425,Phylogenetic and evolutionary analysis of the septin protein family in metazoan.,2007,10.1016/j.febslet.2007.10.032,https://pubmed.ncbi.nlm.nih.gov/17967425/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SEPTIN12,ENSG00000140623,Unsafe,15915442,Expression profiling the human septin gene family.,2005,10.1002/path.1789,https://pubmed.ncbi.nlm.nih.gov/15915442/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SERINC4,ENSG00000184716,Unsafe,41113055,SERINC4 is dispensable for male fertility and spermatogenesis in mice.,2025,10.62347/xcad5724,https://pubmed.ncbi.nlm.nih.gov/41113055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SERINC4,ENSG00000184716,Unsafe,37610843,Altered G-Protein Transduction Protein Gene Expression in the Testis of Infertile Patients with Nonobstructive Azoospermia.,2023,10.1089/dna.2023.0189,https://pubmed.ncbi.nlm.nih.gov/37610843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SERINC4,ENSG00000184716,Unsafe,33521797,Proteasomal degradation of human SERINC4: A potent host anti-HIV-1 factor that is antagonized by nef.,2020,10.1016/j.crviro.2020.100002,https://pubmed.ncbi.nlm.nih.gov/33521797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,42827183,Single-allele nanoscale mapping of regulatory variants.,2026,10.1038/s41588-026-02776-8,https://pubmed.ncbi.nlm.nih.gov/42827183/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,41972739,Sestrins as Biomarkers of Cellular Stress and Human Disease.,2026,10.3390/cells15070651,https://pubmed.ncbi.nlm.nih.gov/41972739/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,41275290,A novel regulatory circuit of ATG4B and SESN3 promotes T cell leukemogenesis.,2025,10.1186/s13046-025-03588-0,https://pubmed.ncbi.nlm.nih.gov/41275290/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,42887617,Low-dose juglone attenuates pressure overload-induced cardiac hypertrophy through Lys207-dependent FoxO1 activation and mitochondrial protection.,2026,10.1016/j.phrs.2026.109685,https://pubmed.ncbi.nlm.nih.gov/42887617/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,40597370,SESN3 restrains the progress of idiopathic pulmonary fibrosis by targeting the activity of FOSL2.,2025,10.1186/s13062-025-00670-7,https://pubmed.ncbi.nlm.nih.gov/40597370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,41632392,Potential Protective Effect of Carotid Endarterectomy: Inducing Ischemic Tolerance in Brain Tissue after Stroke.,2026,10.1007/s12031-025-02470-0,https://pubmed.ncbi.nlm.nih.gov/41632392/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,40507985,Potential Role of SESN3 in Linking Heart Failure with Preserved Ejection Fraction and Chronic Obstructive Pulmonary Disease via Autophagy Dysregulation.,2025,10.3390/ijms26115174,https://pubmed.ncbi.nlm.nih.gov/40507985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,41460862,Sestrin3 confers resistance to recombinant human arginase in small cell lung cancer by activating Akt/mTOR/ASS1 axis.,2025,10.1371/journal.pone.0338802,https://pubmed.ncbi.nlm.nih.gov/41460862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,41355963,Super-enhancer-driven core transcription factor FOXP1 delays endothelial cell senescence via phase separation-mediated SESN3 activation.,2026,10.7150/thno.119709,https://pubmed.ncbi.nlm.nih.gov/41355963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,41836804,Integrated bulk and single-cell transcriptomic profiling reveals bromocriptine sensitivity genes and cellular targets in adenomyosis.,2026,10.12669/pjms.42.2.12639,https://pubmed.ncbi.nlm.nih.gov/41836804/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,41704818,Oxidative stress-mediated responses in endometrial cancer cells: contrasting effects of doxorubicin and menadione.,2026,10.3389/fphys.2026.1733194,https://pubmed.ncbi.nlm.nih.gov/41704818/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,41681982,"Snail1 Induced Suppression of Proliferation via EGR1, FOXO1, and CEPBγ Creates a Vulnerability for Targeting Apoptotic and Cellular Senescence Pathways.",2026,10.3390/cancers18030510,https://pubmed.ncbi.nlm.nih.gov/41681982/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,40174866,"The multifaceted role of Sestrin 3 (SESN3) in oxidative stress, inflammation and tumorigenesis.",2025,10.1016/j.bbamcr.2025.119938,https://pubmed.ncbi.nlm.nih.gov/40174866/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,42599652,Machine Learning-Derived Sarcopenia Signature Identifies High-Risk Molecular State in T2D Skeletal Muscle.,2026,10.1007/s12013-026-02138-5,https://pubmed.ncbi.nlm.nih.gov/42599652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,39863613,Pifithrin-μ sensitizes mTOR-activated liver cancer to sorafenib treatment.,2025,10.1038/s41419-025-07332-6,https://pubmed.ncbi.nlm.nih.gov/39863613/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,39217398,Deciphering glial contributions to CSF1R-related disorder via single-nuclear transcriptomic profiling: a case study.,2024,10.1186/s40478-024-01853-5,https://pubmed.ncbi.nlm.nih.gov/39217398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,42629565,Sex-specific signatures of fetal programming for gestational diabetes mellitus in umbilical cord: A cohort study from Tanzania.,2026,10.1186/s12916-026-05158-3,https://pubmed.ncbi.nlm.nih.gov/42629565/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,39857395,Restoration of Sestrin 3 Expression Mitigates Cardiac Oxidative Damage in Ischemia-Reperfusion Injury Model.,2025,10.3390/antiox14010061,https://pubmed.ncbi.nlm.nih.gov/39857395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,41681932,A TP53-Pathway-Based Prognostic Signature for Radiotherapy and Functional Validation of TP53I3 in Non-Small-Cell Lung Cancer.,2026,10.3390/cancers18030457,https://pubmed.ncbi.nlm.nih.gov/41681932/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,42194988,Type 1 Diabetes and Multiple Sclerosis Share General Autoimmunity Genetic Variation.,2026,10.3390/genes17050531,https://pubmed.ncbi.nlm.nih.gov/42194988/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,41299435,Immune cell-based transcriptomic Mendelian randomization and colocalization study on type 1 diabetes.,2025,10.1186/s12916-025-04527-8,https://pubmed.ncbi.nlm.nih.gov/41299435/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,41720449,Spatially resolved transcriptomics identifies tumor-stroma-immune networks and therapeutic targets in endocrine-resistant advanced breast cancer treated with Everolimus+Letrozole: insights from the MIRACLE trial.,2026,10.1016/j.canlet.2026.218327,https://pubmed.ncbi.nlm.nih.gov/41720449/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,41234887,Unveiling critical genes and molecular subtypes in ovarian cancer: insights into tumor immunity and carbohydrate-lipid metabolism.,2025,10.21037/tcr-2025-745,https://pubmed.ncbi.nlm.nih.gov/41234887/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,38000935,A 9-year-old patient with indolent NK cell lymphoproliferative disorder: What role does an inherited SESN3 mutation play?,2024,10.1016/j.dld.2023.10.023,https://pubmed.ncbi.nlm.nih.gov/38000935/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,41514824,Integrated Transcriptomic and Metabolomic Analysis Reveals the Meat Production Features in Hybrid Sheep.,2026,10.3390/ani16010137,https://pubmed.ncbi.nlm.nih.gov/41514824/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,41357233,A prognostic model for breast cancer survival based on PCD and m6A gene interactions.,2025,10.3389/fimmu.2025.1711910,https://pubmed.ncbi.nlm.nih.gov/41357233/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,39930543,Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci.,2025,10.1186/s13059-025-03492-y,https://pubmed.ncbi.nlm.nih.gov/39930543/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,33082554,Colon and liver tissue damage detection using methylated SESN3 and PTK2B genes in circulating cell-free DNA in patients with acute graft-versus-host disease.,2021,10.1038/s41409-020-01090-z,https://pubmed.ncbi.nlm.nih.gov/33082554/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,33758823,Implication of sestrin3 in epilepsy and its comorbidities.,2021,10.1093/braincomms/fcaa130,https://pubmed.ncbi.nlm.nih.gov/33758823/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SESN3,ENSG00000149212,Unsafe,12607115,PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse.,2003,10.1007/s00439-003-0917-5,https://pubmed.ncbi.nlm.nih.gov/12607115/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,41206037,Mei5-Sae3 stabilizes both active and inactive forms of Dmc1 filaments independently of its impact on ATP hydrolysis.,2025,10.1093/nar/gkaf1085,https://pubmed.ncbi.nlm.nih.gov/41206037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,39174851,CDK phosphorylation of Sfr1 downregulates Rad51 function in late-meiotic homolog invasions.,2024,10.1038/s44318-024-00205-2,https://pubmed.ncbi.nlm.nih.gov/39174851/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,39275989,Mei5-Sae3 stabilizes Dmc1 nucleating clusters for efficient Dmc1 assembly on RPA-coated single-stranded DNA.,2024,10.1093/nar/gkae780,https://pubmed.ncbi.nlm.nih.gov/39275989/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,40091050,Genetic insights into idiopathic pulmonary fibrosis: a multi-omics approach to identify potential therapeutic targets.,2025,10.1186/s12967-025-06368-8,https://pubmed.ncbi.nlm.nih.gov/40091050/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,39195819,"Genomic Sequence of &lt;i&gt;Streptococcus salivarius&lt;/i&gt; MDI13 and &lt;i&gt;Latilactobacillus sakei&lt;/i&gt; MEI5: Two Promising Probiotic Strains Isolated from European Hakes (&lt;i&gt;Merluccius merluccius&lt;/i&gt;, L.).",2024,10.3390/vetsci11080365,https://pubmed.ncbi.nlm.nih.gov/39195819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,37330173,Phosphoregulation of DNA repair via the Rad51 auxiliary factor Swi5-Sfr1.,2023,10.1016/j.jbc.2023.104929,https://pubmed.ncbi.nlm.nih.gov/37330173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,34208949,Mapping and Analysis of Swi5 and Sfr1 Phosphorylation Sites.,2021,10.3390/genes12071014,https://pubmed.ncbi.nlm.nih.gov/34208949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,38144074,MeCP2-Induced Alternations of Transcript Levels and m6A Methylation in Human Retinal Pigment Epithelium Cells.,2023,10.1021/acsomega.3c06610,https://pubmed.ncbi.nlm.nih.gov/38144074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,36428492,Oncogenic Roles of Polycomb Repressive Complex 2 in Bladder Cancer and Upper Tract Urothelial Carcinoma.,2022,10.3390/biomedicines10112925,https://pubmed.ncbi.nlm.nih.gov/36428492/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,31790385,A mutant form of Dmc1 that bypasses the requirement for accessory protein Mei5-Sae3 reveals independent activities of Mei5-Sae3 and Rad51 in Dmc1 filament stability.,2019,10.1371/journal.pgen.1008217,https://pubmed.ncbi.nlm.nih.gov/31790385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,32204793,Cooperative interactions facilitate stimulation of Rad51 by the Swi5-Sfr1 auxiliary factor complex.,2020,10.7554/elife.52566,https://pubmed.ncbi.nlm.nih.gov/32204793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,32350068,Tetrahymena Poc5 is a transient basal body component that is important for basal body maturation.,2020,10.1242/jcs.240838,https://pubmed.ncbi.nlm.nih.gov/32350068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,27904881,"Sfr1, a Tetrahymena thermophila Sfi1 Repeat Protein, Modulates the Production of Cortical Row Basal Bodies.",2016,10.1128/msphere.00257-16,https://pubmed.ncbi.nlm.nih.gov/27904881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,34157114,Rrp1 translocase and ubiquitin ligase activities restrict the genome destabilising effects of Rad51 in fission yeast.,2021,10.1093/nar/gkab511,https://pubmed.ncbi.nlm.nih.gov/34157114/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,23874500,DNA homologous recombination factor SFR1 physically and functionally interacts with estrogen receptor alpha.,2013,10.1371/journal.pone.0068075,https://pubmed.ncbi.nlm.nih.gov/23874500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,28423184,The differentiated and conserved roles of Swi5-Sfr1 in homologous recombination.,2017,10.1002/1873-3468.12656,https://pubmed.ncbi.nlm.nih.gov/28423184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,27131790,Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombination.,2016,10.1093/nar/gkw375,https://pubmed.ncbi.nlm.nih.gov/27131790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,30462332,RPA resolves conflicting activities of accessory proteins during reconstitution of Dmc1-mediated meiotic recombination.,2019,10.1093/nar/gky1160,https://pubmed.ncbi.nlm.nih.gov/30462332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,20976249,Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination.,2010,10.1371/journal.pgen.1001160,https://pubmed.ncbi.nlm.nih.gov/20976249/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,22492707,Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex.,2012,10.1093/nar/gks305,https://pubmed.ncbi.nlm.nih.gov/22492707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,34647356,Global 3'-untranslated region landscape mediated by alternative polyadenylation during meiotic maturation of pig oocytes.,2022,10.1111/rda.14026,https://pubmed.ncbi.nlm.nih.gov/34647356/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,25387876,Comparison of treatment outcomes according to output voltage during shockwave lithotripsy for ureteral calculi: a prospective randomized multicenter study.,2015,10.1007/s00345-014-1438-7,https://pubmed.ncbi.nlm.nih.gov/25387876/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,21779174,The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination.,2011,10.1371/journal.pgen.1002148,https://pubmed.ncbi.nlm.nih.gov/21779174/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SFR1,ENSG00000156384,Unsafe,21252223,The role of the human SWI5-MEI5 complex in homologous recombination repair.,2011,10.1074/jbc.m110.207290,https://pubmed.ncbi.nlm.nih.gov/21252223/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,41143154,Utilizing CRISPR-Cas13d-knockdown in zebrafish to study a rare monogenic bone fragility syndrome.,2025,10.1093/jbmrpl/ziaf153,https://pubmed.ncbi.nlm.nih.gov/41143154/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,42442499,Sphingomyelin synthase 2 regulates host protection conferred by the administration of Cryptococcus neoformans Δsgl1 strain.,2026,10.1016/j.jbc.2026.113330,https://pubmed.ncbi.nlm.nih.gov/42442499/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,42790550,SMS2 inhibition alleviates endothelial dysfunction and atherosclerosis via promoting NFE2L1 expression to suppress ferroptosis.,2026,10.1016/j.freeradbiomed.2026.09.022,https://pubmed.ncbi.nlm.nih.gov/42790550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,42593674,SMS1 and SMS2 differentially regulate platinum chemotherapy sensitivity in ovarian cancer cells.,2026,10.1007/s11033-026-12595-z,https://pubmed.ncbi.nlm.nih.gov/42593674/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,42552306,Human growth plates house resting zone sub-populations with features of quiescent stem cells.,2026,10.1038/s41413-026-00564-y,https://pubmed.ncbi.nlm.nih.gov/42552306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,41316300,SGMS2+ macrophages enhance NR4A3hi NK cell infiltration to improve prognosis and PD-1 treatment efficacy in hepatocellular carcinoma.,2025,10.1186/s12967-025-07040-x,https://pubmed.ncbi.nlm.nih.gov/41316300/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,41347876,Sphingomyelin Synthase 2 Deletion Mitigates Oxidative Stress-Induced NF-κB Activation via Lipid Metabolic Reprogramming in Dry Eye Disease.,2025,10.1167/iovs.66.15.22,https://pubmed.ncbi.nlm.nih.gov/41347876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,41988717,Inhibiting Endothelial SMS2 Alleviates Atherosclerosis by Blocking Endothelial‑Mesenchymal Transition Through Boosted Fatty Acid Oxidation.,2026,10.1161/atvbaha.126.324346,https://pubmed.ncbi.nlm.nih.gov/41988717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,40978119,Transcriptomic and lipidomic profiling provide novel insight into the pathogenesis of monogenic &lt;i&gt;SGMS2&lt;/i&gt;-related osteoporosis.,2025,10.1093/jbmrpl/ziaf128,https://pubmed.ncbi.nlm.nih.gov/40978119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,41707846,Ceramide metabolism in oxidative and glycolytic muscle: Significance for lipid-induced insulin resistance.,2026,10.1016/j.molmet.2026.102336,https://pubmed.ncbi.nlm.nih.gov/41707846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,37886644,SGMS2 in primary osteoporosis with facial nerve palsy.,2023,10.3389/fendo.2023.1224318,https://pubmed.ncbi.nlm.nih.gov/37886644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,41821748,Pathogenic &lt;i&gt;SGMS2&lt;/i&gt; variants are not a common cause of early-onset osteoporosis among Finnish patients.,2026,10.3389/fendo.2026.1719375,https://pubmed.ncbi.nlm.nih.gov/41821748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,41268620,The Role of Sphingomyelin Synthase 2 in Lipid Metabolism and Its Implications in Diseases.,2026,10.1002/cbin.70103,https://pubmed.ncbi.nlm.nih.gov/41268620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,40123745,A novel SGMS2 mutation associated with high bone mass; description of an affected family with recurrent fragility fractures.,2025,10.1016/j.bonr.2025.101833,https://pubmed.ncbi.nlm.nih.gov/40123745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,39739672,Hypoxia-induced increase in sphingomyelin synthase 2 aggravates ischemic skeletal muscle inflammation.,2025,10.1111/febs.17379,https://pubmed.ncbi.nlm.nih.gov/39739672/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,41913146,How deep resolve affects the stability of texture features for different MR image acceleration methods - a phantom and a human brain study.,2026,10.1186/s12880-026-02317-z,https://pubmed.ncbi.nlm.nih.gov/41913146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,42879058,Docosahexaenoic acid remodels lipid composition of lipid rafts and mitochondrial function in ApoE4/4 mouse brain: a multi-omic investigation.,2026,10.1186/s43556-026-00618-x,https://pubmed.ncbi.nlm.nih.gov/42879058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,40834073,Tandem repeat-induced sexual silencing: A Rid-dependent RNAi mechanism for fungal genome defense via translational repression.,2025,10.1126/sciadv.adu7606,https://pubmed.ncbi.nlm.nih.gov/40834073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,41270786,Effect of Lactiplantibacillus mudanjiangensis strain isolated from post-fermented tea on dermal health.,2025,10.1163/18762891-bja00105,https://pubmed.ncbi.nlm.nih.gov/41270786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,41877782,Identification of plasma biomarkers in a PTZ-induced Sudden Unexpected Death-like model through integrated proteomics and metabolomics methods.,2026,10.3389/fmed.2026.1774546,https://pubmed.ncbi.nlm.nih.gov/41877782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,40651373,Memory impairment mediated by deoxynivalenol via the BLA-PrL circuit.,2025,10.1016/j.jhazmat.2025.139172,https://pubmed.ncbi.nlm.nih.gov/40651373/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,40041909,Discovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy.,2025,10.1016/j.apsb.2024.10.005,https://pubmed.ncbi.nlm.nih.gov/40041909/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,40158738,Stromal Stiffness-Regulated IGF2BP2 in Pancreatic Cancer Drives Immune Evasion via Sphingomyelin Metabolism.,2025,10.1053/j.gastro.2025.03.019,https://pubmed.ncbi.nlm.nih.gov/40158738/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,41463320,Integrative Single-Cell and Machine Learning Analysis Develops a Glutamine Metabolism-Based Prognostic Model and Identifies MSMO1 as a Therapeutic Target in Osteosarcoma.,2025,10.3390/biom15121664,https://pubmed.ncbi.nlm.nih.gov/41463320/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,39848207,Transcriptomic and metabolomic-based revelation of the effect of fresh corn extract on meat quality of Jingyuan chicken.,2025,10.1016/j.psj.2025.104814,https://pubmed.ncbi.nlm.nih.gov/39848207/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,41450556,Sphingomyelin synthase inhibitors from edible mushrooms prevent overweight and improve vitamin D homeostasis in a mouse model of diet-induced obesity.,2025,10.3389/fnut.2025.1658130,https://pubmed.ncbi.nlm.nih.gov/41450556/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,37175737,Clinical and Genetic Characteristics of Calvarial Doughnut Lesions with Bone Fragility in Three Families with a Reccurent SGMS2 Gene Variant.,2023,10.3390/ijms24098021,https://pubmed.ncbi.nlm.nih.gov/37175737/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,36691044,LARP6 suppresses colorectal cancer progression through ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesis.,2023,10.1186/s13046-023-02605-4,https://pubmed.ncbi.nlm.nih.gov/36691044/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,41517371,Spectrum of Osteoporosis Etiologies with Associated Vertebral Compression Fractures in Children: Analysis of 11 Cases.,2025,10.3390/jcm15010123,https://pubmed.ncbi.nlm.nih.gov/41517371/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,40890164,Identification of candidate gene networks affecting the number of somatic cells count and milk production in Iranian Holstein cows using Genome-wide association study.,2025,10.1038/s41598-025-09103-x,https://pubmed.ncbi.nlm.nih.gov/40890164/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,36090706,Bioinformatics Analysis of the Key Genes and Pathways in Multiple Myeloma.,2022,10.2147/ijgm.s377321,https://pubmed.ncbi.nlm.nih.gov/36090706/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,34064003,Onset of Senescence and Steatosis in Hepatocytes as a Consequence of a Shift in the Diacylglycerol/Ceramide Balance at the Plasma Membrane.,2021,10.3390/cells10061278,https://pubmed.ncbi.nlm.nih.gov/34064003/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,32451413,Sphingomyelin synthase 2 facilitates M2-like macrophage polarization and tumor progression in a mouse model of triple-negative breast cancer.,2021,10.1038/s41401-020-0419-1,https://pubmed.ncbi.nlm.nih.gov/32451413/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,31517509,Airway Resistance Caused by Sphingomyelin Synthase 2 Insufficiency in Response to Cigarette Smoke.,2020,10.1165/rcmb.2019-0133oc,https://pubmed.ncbi.nlm.nih.gov/31517509/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,38785931,Unraveling the Etiology of Dilated Cardiomyopathy through Differential miRNA-mRNA Interactome.,2024,10.3390/biom14050524,https://pubmed.ncbi.nlm.nih.gov/38785931/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,36056909,Risk stratification and prognosis prediction based on inflammation-related gene signature in lung squamous carcinoma.,2023,10.1002/cam4.5190,https://pubmed.ncbi.nlm.nih.gov/36056909/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,30646599,The Opposing Contribution of SMS1 and SMS2 to Glioma Progression and Their Value in the Therapeutic Response to 2OHOA.,2019,10.3390/cancers11010088,https://pubmed.ncbi.nlm.nih.gov/30646599/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,33226447,Overriding sorafenib resistance via blocking lipid metabolism and Ras by sphingomyelin synthase 1 inhibition in hepatocellular carcinoma.,2021,10.1007/s00280-020-04199-6,https://pubmed.ncbi.nlm.nih.gov/33226447/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGMS2,ENSG00000164023,Unsafe,14685263,Identification of a family of animal sphingomyelin synthases.,2004,10.1038/sj.emboj.7600034,https://pubmed.ncbi.nlm.nih.gov/14685263/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,42287003,SGO1 and SGO2 are Associated With Disease Progression and an Immunosuppressive Microenvironment in Papillary Renal Cell Carcinoma.,2026,10.1002/cam4.72034,https://pubmed.ncbi.nlm.nih.gov/42287003/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,41290833,Identification of novel biomarkers for epithelial ovarian cancer through machine learning and explainable artificial intelligence using in silico and in vitro analysis.,2025,10.1038/s41598-025-25901-9,https://pubmed.ncbi.nlm.nih.gov/41290833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,41872739,Functional analyses of homoeologous pericentromeric cohesion protective genes TaSGO1s during meiosis in Triticum aestivum.,2026,10.1186/s12870-026-08619-2,https://pubmed.ncbi.nlm.nih.gov/41872739/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,40861810,Pan-cancer analysis reveals SGO1 as a potential cancer prognostic and immunological biomarker.,2025,10.7150/jca.115334,https://pubmed.ncbi.nlm.nih.gov/40861810/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,42789221,A CDC20 allelic series reveals stage-specific control of metaphase-to-anaphase transitions during mitosis and meiosis in rice.,2026,10.1007/s11427-026-3515-0,https://pubmed.ncbi.nlm.nih.gov/42789221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,41786187,Shugoshin holds the potential to inhibit APC/C and thereby prevents separase activation.,2026,10.1016/j.ijbiomac.2026.151175,https://pubmed.ncbi.nlm.nih.gov/41786187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,38383432,Prognosis and biological function of SGOL1 in clear cell renal cell carcinoma: a multiomics analysis.,2024,10.1186/s12920-024-01825-7,https://pubmed.ncbi.nlm.nih.gov/38383432/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,39476301,Shugoshin 1 expression in various cancers: a potential target for therapy.,2025,10.1007/s12094-024-03749-1,https://pubmed.ncbi.nlm.nih.gov/39476301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,41688416,Emerging Regulatory Mechanisms in Sinoatrial Node Automaticity.,2026,10.1111/jcmm.71058,https://pubmed.ncbi.nlm.nih.gov/41688416/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,42556348,α-Satellite RNA maintains centromeric cohesion through R-loops.,2026,10.1016/j.molcel.2026.07.023,https://pubmed.ncbi.nlm.nih.gov/42556348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,41245052,Chronic atrial and intestinal dysrythmia syndrome: A late-onset intestinal pseudo-obstruction and cardiac dysfunction due to an SGO1 mutation.,2025,10.1002/jpr3.70060,https://pubmed.ncbi.nlm.nih.gov/41245052/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,36387443,SGOL1-AS1 enhances cell survival in acute myeloid leukemia by maintaining pro-inflammatory signaling.,2022,10.1016/j.heliyon.2022.e11362,https://pubmed.ncbi.nlm.nih.gov/36387443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,36439418,Identification and validation of a potential key gene SGOL1 for poor prognosis in hepatocellular carcinoma based on a bioinformatics approach.,2022,10.3389/fonc.2022.1043161,https://pubmed.ncbi.nlm.nih.gov/36439418/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,40258920,Genome-wide association analysis reveals insights into the genetic architecture of mesenteric torsion in pigs.,2025,10.1038/s41598-025-98029-5,https://pubmed.ncbi.nlm.nih.gov/40258920/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,39271794,Requirement of Nek2a and cyclin A2 for Wapl-dependent removal of cohesin from prophase chromatin.,2024,10.1038/s44318-024-00228-9,https://pubmed.ncbi.nlm.nih.gov/39271794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,41767060,A 10-Year-Old Boy With Chronic Atrial and Intestinal Dysrhythmia (CAID) and Chronic Intestinal Pseudo-Obstruction (CIPO).,2026,10.1002/ccr3.72111,https://pubmed.ncbi.nlm.nih.gov/41767060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,39804939,The dependence of shugoshin on Bub1-kinase activity is dispensable for the maintenance of spindle assembly checkpoint response in Cryptococcus neoformans.,2025,10.1371/journal.pgen.1011552,https://pubmed.ncbi.nlm.nih.gov/39804939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,37777834,Sgo1 interacts with CENP-A to guide accurate chromosome segregation in mitosis.,2024,10.1093/jmcb/mjad061,https://pubmed.ncbi.nlm.nih.gov/37777834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,40386336,Chronic atrial and intestinal dysrhythmia: A rare genetic disorder of intestinal pseudo-obstruction.,2025,10.1002/jpr3.12158,https://pubmed.ncbi.nlm.nih.gov/40386336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,35592680,Deciphering the Role of Shugoshin-Like Protein 1 in Lung Adenocarcinoma: A Comprehensive Analysis and In Vitro Study.,2022,10.3389/fonc.2022.898920,https://pubmed.ncbi.nlm.nih.gov/35592680/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,39921047,Integrative analysis of bulk RNA and single-cell sequencing data reveals a liquid-liquid phase separation signature for clear cell renal cell carcinoma.,2025,10.1016/j.gene.2025.149313,https://pubmed.ncbi.nlm.nih.gov/39921047/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,37122033,Sustained Shugoshin 1 downregulation reduces tumor growth and metastasis in a mouse xenograft tumor model of triple-negative breast cancer.,2023,10.1186/s13008-023-00088-5,https://pubmed.ncbi.nlm.nih.gov/37122033/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,40273626,"Vitamin K2 mitigates cognitive, and motor impairments induced by multiple surgery with anesthesia and analgesia in neonatal stage.",2025,10.1016/j.bbrc.2025.151784,https://pubmed.ncbi.nlm.nih.gov/40273626/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,37596441,Hornerin mediates phosphorylation of the polo-box domain in Plk1 by Chk1 to induce death in mitosis.,2023,10.1038/s41418-023-01208-y,https://pubmed.ncbi.nlm.nih.gov/37596441/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,39942140,"The Effects of Light Crystal Display 3D Printers, Storage Time and Steam Sterilization on the Dimensional Stability of a Photopolymer Resin for Surgical Guides: An In Vitro Study.",2025,10.3390/ma18030474,https://pubmed.ncbi.nlm.nih.gov/39942140/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,41301931,TIM-3 Promotes Proliferation of Acute Myeloid Leukemia Blasts.,2025,10.3390/biomedicines13112841,https://pubmed.ncbi.nlm.nih.gov/41301931/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,39110738,Molecular mechanism and functional significance of Wapl interaction with the Cohesin complex.,2024,10.1073/pnas.2405177121,https://pubmed.ncbi.nlm.nih.gov/39110738/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,31911855,SGO1 induces proliferation and metastasis of prostate cancer through AKT-mediated signaling pathway.,2019,,https://pubmed.ncbi.nlm.nih.gov/31911855/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,32923148,Identification of tumor-infiltrating immune cells and prognostic validation of tumor-infiltrating mast cells in adrenocortical carcinoma: results from bioinformatics and real-world data.,2020,10.1080/2162402x.2020.1784529,https://pubmed.ncbi.nlm.nih.gov/32923148/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,34925867,Inhibitors of the Bub1 spindle assembly checkpoint kinase: synthesis of BAY-320 and comparison with 2OH-BNPP1.,2021,10.1098/rsos.210854,https://pubmed.ncbi.nlm.nih.gov/34925867/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,28980861,Budding yeast CENP-ACse4 interacts with the N-terminus of Sgo1 and regulates its association with centromeric chromatin.,2018,10.1080/15384101.2017.1380129,https://pubmed.ncbi.nlm.nih.gov/28980861/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,27526110,"Systemic chromosome instability in Shugoshin-1 mice resulted in compromised glutathione pathway, activation of Wnt signaling and defects in immune system in the lung.",2016,10.1038/oncsis.2016.56,https://pubmed.ncbi.nlm.nih.gov/27526110/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,32620073,Methotrexate impaired in-vivo matured mouse oocyte quality and the possible mechanisms.,2020,10.1186/s12860-020-00298-7,https://pubmed.ncbi.nlm.nih.gov/32620073/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,30231670,Critical role of mitosis in spontaneous late-onset Alzheimer's disease; from a Shugoshin 1 cohesinopathy mouse model.,2018,10.1080/15384101.2018.1515554,https://pubmed.ncbi.nlm.nih.gov/30231670/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,30666557,CRISPR/Cas9 for overcoming drug resistance in solid tumors.,2020,10.1007/s40199-019-00240-z,https://pubmed.ncbi.nlm.nih.gov/30666557/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO1,ENSG00000129810,Unsafe,12747765,Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.,2001,,https://pubmed.ncbi.nlm.nih.gov/12747765/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,42287003,SGO1 and SGO2 are Associated With Disease Progression and an Immunosuppressive Microenvironment in Papillary Renal Cell Carcinoma.,2026,10.1002/cam4.72034,https://pubmed.ncbi.nlm.nih.gov/42287003/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,42382700,Silencing SGO2 by Oxamic Acid Dissociates Glycolysis and BRCA1-Mediated DNA Repair to Improve the Chemosensitivity of Lung Adenocarcinoma.,2026,10.1002/exp.20250098,https://pubmed.ncbi.nlm.nih.gov/42382700/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,42697347,Cycloechinulin inhibits breast cancer progression via the SGOL2/METTL3/ICAM2 signaling axis and suppresses the growth of breast cancer patient-derived organoids.,2026,10.1016/j.cellsig.2026.112875,https://pubmed.ncbi.nlm.nih.gov/42697347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,41340734,Comprehensive Analysis and Experimental Validation of Single-Cell and Transcriptome Sequencing Reveal SGO2 as a Novel Biomarker for Breast Cancer.,2025,10.2147/bctt.s561588,https://pubmed.ncbi.nlm.nih.gov/41340734/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,40664832,Elevated SGO2 expression in lung adenocarcinoma promotes migration and invasion via MAD2 and correlates with poor prognosis.,2025,10.1038/s41598-025-10993-0,https://pubmed.ncbi.nlm.nih.gov/40664832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,42498793,The deSUMOylase SPF2 and the cohesin regulators SGO2 and CTF18 suppress crossovers near centromeres.,2026,10.1038/s41477-026-02329-1,https://pubmed.ncbi.nlm.nih.gov/42498793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,41637509,Hybrid female sterility due to cohesin protection errors in mouse oocytes.,2026,10.1126/sciadv.adx9729,https://pubmed.ncbi.nlm.nih.gov/41637509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,40520116,Histone deacetylation as a landmark for Sgo2 relocation from centromeres to subtelomeres during interphase.,2025,10.1016/j.isci.2025.112717,https://pubmed.ncbi.nlm.nih.gov/40520116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,40267054,SGO2 does not play an essential role in separase inhibition during meiosis I in mouse oocytes.,2025,10.1371/journal.pbio.3003131,https://pubmed.ncbi.nlm.nih.gov/40267054/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,39344317,"SGO2 as a Prognostic Biomarker Correlated with Cell Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition in Lung Adenocarcinoma.",2024,10.31083/j.fbl2909314,https://pubmed.ncbi.nlm.nih.gov/39344317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,42095660,Replication-competent SIVcpz CRISPR screen identifies barriers to successful cross-species transmission.,2026,10.1128/jvi.00314-26,https://pubmed.ncbi.nlm.nih.gov/42095660/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,40522965,Nuances in the control of separase activity between mitosis and meiosis.,2025,10.1371/journal.pbio.3003206,https://pubmed.ncbi.nlm.nih.gov/40522965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,36566018,SGOL2 promotes prostate cancer progression by inhibiting RAB1A ubiquitination.,2022,10.18632/aging.204443,https://pubmed.ncbi.nlm.nih.gov/36566018/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,37576392,"High SGO2 predicted poor prognosis and high therapeutic value of lung adenocarcinoma and promoted cell proliferation, migration, invasion, and epithelial-to-mesenchymal transformation.",2023,10.7150/jca.86285,https://pubmed.ncbi.nlm.nih.gov/37576392/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,36380369,SGOL2 is a novel prognostic marker and fosters disease progression via a MAD2-mediated pathway in hepatocellular carcinoma.,2022,10.1186/s40364-022-00422-z,https://pubmed.ncbi.nlm.nih.gov/36380369/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,38134935,Age-dependent loss of cohesion protection in human oocytes.,2024,10.1016/j.cub.2023.11.061,https://pubmed.ncbi.nlm.nih.gov/38134935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,34535705,Shugosin 2 is a biomarker for pathological grading and survival prediction in patients with gliomas.,2021,10.1038/s41598-021-97119-4,https://pubmed.ncbi.nlm.nih.gov/34535705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,40017443,Decoding the Molecular Landscape of Prepubertal Oocyte Maturation: GTPBP4 as a Key Driver of In Vitro Developmental Competence.,2025,10.1111/cpr.70017,https://pubmed.ncbi.nlm.nih.gov/40017443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,40764838,Eliminating separase inhibition reveals absence of robust cohesin protection in oocyte metaphase II.,2025,10.1038/s44318-025-00522-0,https://pubmed.ncbi.nlm.nih.gov/40764838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,34200261,High SGO2 Expression Predicts Poor Overall Survival: A Potential Therapeutic Target for Hepatocellular Carcinoma.,2021,10.3390/genes12060876,https://pubmed.ncbi.nlm.nih.gov/34200261/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,34956967,Key Candidate Prognostic Biomarkers Correlated with Immune Infiltration in Hepatocellular Carcinoma.,2021,10.2147/jhc.s337067,https://pubmed.ncbi.nlm.nih.gov/34956967/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,32923148,Identification of tumor-infiltrating immune cells and prognostic validation of tumor-infiltrating mast cells in adrenocortical carcinoma: results from bioinformatics and real-world data.,2020,10.1080/2162402x.2020.1784529,https://pubmed.ncbi.nlm.nih.gov/32923148/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,36072975,Novel DNA Damage-Related Subtypes Characterization Identifies Uterine Corpus Endometrial Carcinoma (UCEC) Based on Machine Learning.,2022,10.1155/2022/3588117,https://pubmed.ncbi.nlm.nih.gov/36072975/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,31886561,Shugoshin 2-a new guardian for heat shock transcription.,2020,10.15252/embj.2019104077,https://pubmed.ncbi.nlm.nih.gov/31886561/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,32973131,SET/TAF1 forms a distance-dependent feedback loop with Aurora B and Bub1 as a tension sensor at centromeres.,2020,10.1038/s41598-020-71955-2,https://pubmed.ncbi.nlm.nih.gov/32973131/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,31214493,The Ectopic Expression of Meiosis Regulatory Genes in Cutaneous T-Cell Lymphomas (CTCL).,2019,10.3389/fonc.2019.00429,https://pubmed.ncbi.nlm.nih.gov/31214493/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,33859719,Comprehensive Analysis of the Control of Cancer Stem Cell Characteristics in Endometrial Cancer by Network Analysis.,2021,10.1155/2021/6653295,https://pubmed.ncbi.nlm.nih.gov/33859719/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,33778011,Cell Division Cycle Associated Genes as Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma.,2021,10.3389/fmolb.2021.657161,https://pubmed.ncbi.nlm.nih.gov/33778011/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,35117216,Comprehensive analysis of transcriptome data stemness indices identifies key genes for controlling cancer stem cell characteristics in gastric cancer.,2020,10.21037/tcr-20-704,https://pubmed.ncbi.nlm.nih.gov/35117216/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SGO2,ENSG00000163535,Unsafe,21402792,The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment.,2011,10.1083/jcb.201008023,https://pubmed.ncbi.nlm.nih.gov/21402792/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SH2D7,ENSG00000183476,Unsafe,38988920,Value analysis of ITLN1 in the diagnostic and prognostic assessment of colorectal cancer.,2024,10.21037/tcr-24-137,https://pubmed.ncbi.nlm.nih.gov/38988920/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,42364863,SHC4 suppresses ferroptosis and promotes sorafenib resistance in hepatocellular carcinoma by disrupting the interaction between NCOA4 and FTH1.,2026,10.1016/j.cellsig.2026.112699,https://pubmed.ncbi.nlm.nih.gov/42364863/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,41392689,Deletion of Adaptor Protein ShcD Impairs Olfactory Bulb Morphology and Function.,2026,10.1080/10985549.2025.2567559,https://pubmed.ncbi.nlm.nih.gov/41392689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,40152177,ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling.,2025,10.1002/1878-0261.70022,https://pubmed.ncbi.nlm.nih.gov/40152177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,42633952,Whole-Genome Resequencing Reveals Selection Signatures Associated With Lambskin Patterns in Hu Sheep.,2026,10.1002/age.70186,https://pubmed.ncbi.nlm.nih.gov/42633952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,41832213,Unbiased characterization of COVID-19 endotypes leads to prognostication of high-risk individuals using routine blood tests.,2026,10.1038/s43856-026-01520-x,https://pubmed.ncbi.nlm.nih.gov/41832213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,33495401,Adaptor Protein ShcD/SHC4 Interacts with Tie2 Receptor to Synergistically Promote Glioma Cell Invasion.,2021,10.1158/1541-7786.mcr-20-0188,https://pubmed.ncbi.nlm.nih.gov/33495401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,41454603,Dose dependent nanoparticle albumin bound paclitaxel + pembrolizumab alters the immune micro environment in a esophageal homograft mouse model.,2025,10.1080/1120009x.2025.2607798,https://pubmed.ncbi.nlm.nih.gov/41454603/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,38052369,SHC4 orchestrates β-catenin pathway-mediated metastasis in triple-negative breast cancer by promoting Src kinase autophosphorylation.,2024,10.1016/j.canlet.2023.216516,https://pubmed.ncbi.nlm.nih.gov/38052369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,35033067,SHC4 promotes tumor proliferation and metastasis by activating STAT3 signaling in hepatocellular carcinoma.,2022,10.1186/s12935-022-02446-9,https://pubmed.ncbi.nlm.nih.gov/35033067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,31823725,Localization of phosphotyrosine adaptor protein ShcD/SHC4 in the adult rat central nervous system.,2019,10.1186/s12868-019-0541-5,https://pubmed.ncbi.nlm.nih.gov/31823725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,36290460,Identification of the Factor That Leads Human Mesenchymal Stem Cell Lines into Decellularized Bone.,2022,10.3390/bioengineering9100490,https://pubmed.ncbi.nlm.nih.gov/36290460/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,38965607,Congenital syndromic Chiari-like malformation (CSCM) in Holstein cattle: towards unravelling of possible genetic causes.,2024,10.1186/s13028-024-00752-y,https://pubmed.ncbi.nlm.nih.gov/38965607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,39884456,Multiomic Sequencing of Intermediate- to High-Risk Cutaneous Squamous Cell Carcinoma Identifies Critical Genes and Expression Patterns Associated with Disease and Poor Outcomes.,2025,10.1016/j.jid.2025.01.015,https://pubmed.ncbi.nlm.nih.gov/39884456/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,35039607,Construction of a potential microRNA and messenger RNA regulatory network of acute lung injury in mice.,2022,10.1038/s41598-022-04800-3,https://pubmed.ncbi.nlm.nih.gov/35039607/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,39834541,The analysis of gene co-expression network and immune infiltration revealed biomarkers between triple-negative and non-triple negative breast cancer.,2024,10.3389/fgene.2024.1505011,https://pubmed.ncbi.nlm.nih.gov/39834541/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,33202906,"ShcD Binds DOCK4, Promotes Ameboid Motility and Metastasis Dissemination, Predicting Poor Prognosis in Melanoma.",2020,10.3390/cancers12113366,https://pubmed.ncbi.nlm.nih.gov/33202906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,28724758,The ShcD phosphotyrosine adaptor subverts canonical EGF receptor trafficking.,2017,10.1242/jcs.198903,https://pubmed.ncbi.nlm.nih.gov/28724758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,36683494,Role of gene signature regulation in tumor immune microenvironment on the mechanism of uveal melanoma metastasis.,2023,10.3233/cbm-210427,https://pubmed.ncbi.nlm.nih.gov/36683494/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,32494663,"miR-26a regulates extracellular vesicle secretion from prostate cancer cells via targeting SHC4, PFDN4, and CHORDC1.",2020,10.1126/sciadv.aay3051,https://pubmed.ncbi.nlm.nih.gov/32494663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,31524262,Role of TGF‑β in the motility of ShcD‑overexpressing 293 cells.,2019,10.3892/mmr.2019.10517,https://pubmed.ncbi.nlm.nih.gov/31524262/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,32079958,Building Patient-Physician Trust: A Medical Student Perspective.,2020,10.1097/acm.0000000000003201,https://pubmed.ncbi.nlm.nih.gov/32079958/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,33316777,Immune-related gene signature predicts overall survival of gastric cancer patients with varying microsatellite instability status.,2020,10.18632/aging.202271,https://pubmed.ncbi.nlm.nih.gov/33316777/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,35202715,Deciphering potential pharmacological mechanisms of Danhong injection to treat chronic stable angina based on drug response-related modules and genes.,2022,10.1016/j.jep.2022.115125,https://pubmed.ncbi.nlm.nih.gov/35202715/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,29556564,The role of the ShcD and RET interaction in neuroblastoma survival and migration.,2018,10.1016/j.bbrep.2018.01.007,https://pubmed.ncbi.nlm.nih.gov/29556564/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,28841874,Science of health care delivery milestones for undergraduate medical education.,2017,10.1186/s12909-017-0986-0,https://pubmed.ncbi.nlm.nih.gov/28841874/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,33619116,NPM-ALK-Induced Reprogramming of Mature TCR-Stimulated T Cells Results in Dedifferentiation and Malignant Transformation.,2021,10.1158/0008-5472.can-20-2297,https://pubmed.ncbi.nlm.nih.gov/33619116/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,36714595,"Overweight/obesity-related transcriptomic signature as a correlate of clinical outcome, immune microenvironment, and treatment response in hepatocellular carcinoma.",2022,10.3389/fendo.2022.1061091,https://pubmed.ncbi.nlm.nih.gov/36714595/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,36274625,Moving preinduction cervical ripening to a lower acuity inpatient setting using the synthetic hygroscopic cervical dilator: a cost-consequence analysis for the United States.,2022,10.1080/13696998.2022.2136854,https://pubmed.ncbi.nlm.nih.gov/36274625/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,35194440,The miR-142 Suppresses U-87 Glioblastoma Cell Growth by Targeting EGFR Oncogenic Signaling Pathway.,2021,10.22037/ijpr.2021.115089.15193,https://pubmed.ncbi.nlm.nih.gov/35194440/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,23638386,A new 12-gene diagnostic biomarker signature of melanoma revealed by integrated microarray analysis.,2013,10.7717/peerj.49,https://pubmed.ncbi.nlm.nih.gov/23638386/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,25812627,Cord blood gene expression supports that prenatal exposure to perfluoroalkyl substances causes depressed immune functionality in early childhood.,2016,10.3109/1547691x.2015.1029147,https://pubmed.ncbi.nlm.nih.gov/25812627/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHC4,ENSG00000185634,Unsafe,17409413,"RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas.",2007,10.1158/0008-5472.can-06-2301,https://pubmed.ncbi.nlm.nih.gov/17409413/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHCBP1L,ENSG00000157060,Unsafe,38912589,Protein disulfide isomerase is essential for spermatogenesis in mice.,2024,10.1172/jci.insight.177743,https://pubmed.ncbi.nlm.nih.gov/38912589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHCBP1L,ENSG00000157060,Unsafe,36611846,"CLPP Depletion Causes Diplotene Arrest; Underlying Testis Mitochondrial Dysfunction Occurs with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2.",2022,10.3390/cells12010052,https://pubmed.ncbi.nlm.nih.gov/36611846/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHCBP1L,ENSG00000157060,Unsafe,34438721,Identification and Characterization of lncRNA and mRNA in Testes of Landrace and Hezuo Boars.,2021,10.3390/ani11082263,https://pubmed.ncbi.nlm.nih.gov/34438721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHCBP1L,ENSG00000157060,Unsafe,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHCBP1L,ENSG00000157060,Unsafe,31605445,Hypothalamic transcriptome of tame and aggressive silver foxes (Vulpes vulpes) identifies gene expression differences shared across brain regions.,2020,10.1111/gbb.12614,https://pubmed.ncbi.nlm.nih.gov/31605445/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHCBP1L,ENSG00000157060,Unsafe,33238277,Fertility Relevance Probability Analysis Shortlists Genetic Markers for Male Fertility Impairment.,2020,10.1159/000511117,https://pubmed.ncbi.nlm.nih.gov/33238277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHCBP1L,ENSG00000157060,Unsafe,24557841,"SHCBP1L, a conserved protein in mammals, is predominantly expressed in male germ cells and maintains spindle stability during meiosis in testis.",2014,10.1093/molehr/gau014,https://pubmed.ncbi.nlm.nih.gov/24557841/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHCBP1L,ENSG00000157060,Unsafe,11318611,Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus.,2001,10.1006/geno.2001.6500,https://pubmed.ncbi.nlm.nih.gov/11318611/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,42258546,XPF-like domain in human SHOC1 is required for crossover formation and protecting autosome from MSUC.,2026,10.1093/nar/gkag558,https://pubmed.ncbi.nlm.nih.gov/42258546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,42473771,WGCNA combined with machine learning identifies histone deacetylation-related diagnostic features for pediatric septic shock.,2026,10.4196/kjpp.25.406,https://pubmed.ncbi.nlm.nih.gov/42473771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,41474474,Calcium signaling-mediated phosphorylation controls zinc allocation in Arabidopsis.,2025,10.1007/s44154-025-00276-z,https://pubmed.ncbi.nlm.nih.gov/41474474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,41894234,Crossover formation and coordinated assembly of synaptonemal complex relies on a direct interaction between Zip1 and Zip3.,2026,10.1093/genetics/iyag075,https://pubmed.ncbi.nlm.nih.gov/41894234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,41585490,Synthetic zipper mediated pre-targeting system for near-infrared photoimmunotherapy.,2026,10.1016/j.isci.2025.114558,https://pubmed.ncbi.nlm.nih.gov/41585490/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,36440627,M1AP interacts with the mammalian ZZS complex and promotes male meiotic recombination.,2023,10.15252/embr.202255778,https://pubmed.ncbi.nlm.nih.gov/36440627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,41300722,Is the TEX11-.652del237bp Exonic In-Frame Deletion Variant Associated with Azoospermia? The Results of an &lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Silico&lt;/i&gt; Study.,2025,10.3390/genes16111270,https://pubmed.ncbi.nlm.nih.gov/41300722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,40374915,Genotype-specific differences in infertile men due to loss-of-function variants in M1AP or ZZS genes.,2025,10.1038/s44321-025-00244-0,https://pubmed.ncbi.nlm.nih.gov/40374915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,41720360,Zinc transporters and cardiac pathophysiology.,2026,10.1016/j.freeradbiomed.2026.02.045,https://pubmed.ncbi.nlm.nih.gov/41720360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,40663571,"Four ZIPs contribute to Zn, Fe, Cu and Mn acquisition at the outer root domain.",2025,10.1371/journal.pgen.1011796,https://pubmed.ncbi.nlm.nih.gov/40663571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,41586242,Supplementation of zinc-chelating peptides from &lt;i&gt;Holothuria scabra&lt;/i&gt; improve zinc status in the offspring of zinc-deficient rats.,2025,10.3389/fnut.2025.1693713,https://pubmed.ncbi.nlm.nih.gov/41586242/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,42901081,Selenium aggravates carbon-nitrogen metabolic imbalance by promoting copper uptake and translocation in apple (Malus domestica Borkh.) plants under copper stress.,2026,10.1016/j.plaphy.2026.111870,https://pubmed.ncbi.nlm.nih.gov/42901081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,40553912,A coiled coil-based pre-targeting drug delivery system for precise treatment of breast cancer.,2025,10.1016/j.ejpb.2025.114794,https://pubmed.ncbi.nlm.nih.gov/40553912/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,40376536,Establishment and clinical significance of genetic factor screening method for patients with nonobstructive azoospermia based on whole exon sequencing technology.,2025,10.21037/tau-2024-676,https://pubmed.ncbi.nlm.nih.gov/40376536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,32900840,Bi-allelic SHOC1 loss-of-function mutations cause meiotic arrest and non-obstructive azoospermia.,2021,10.1136/jmedgenet-2020-107042,https://pubmed.ncbi.nlm.nih.gov/32900840/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,41285321,circSHOC1-SLC25A3 promotes 2-naphthylamine-induced DNA damage in bronchial epithelial cells via activation of oxidative stress.,2026,10.1016/j.taap.2025.117652,https://pubmed.ncbi.nlm.nih.gov/41285321/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,30746471,SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I.,2019,10.1126/sciadv.aau9780,https://pubmed.ncbi.nlm.nih.gov/30746471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,39678461,A comprehensive study of common and rare genetic variants in spermatogenesis-related loci identifies new risk factors for idiopathic severe spermatogenic failure.,2024,10.1093/hropen/hoae069,https://pubmed.ncbi.nlm.nih.gov/39678461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,38999774,Emerging Perspectives in Zinc Transporter Research in Prostate Cancer: An Updated Review.,2024,10.3390/nu16132026,https://pubmed.ncbi.nlm.nih.gov/38999774/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,29742103,"SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of crossover recombination intermediates during mammalian meiosis.",2018,10.1371/journal.pgen.1007381,https://pubmed.ncbi.nlm.nih.gov/29742103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,36332446,Molecular characteristics of pediatric nasopharyngeal carcinoma using whole-exome sequencing.,2022,10.1016/j.oraloncology.2022.106218,https://pubmed.ncbi.nlm.nih.gov/36332446/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,36625901,Rhizophagus irregularis improves Hg tolerance of Medicago truncatula by upregulating the Zn transporter genes ZIP2 and ZIP6.,2023,10.1007/s00572-022-01100-6,https://pubmed.ncbi.nlm.nih.gov/36625901/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,35371096,The Transcription of ZIP9 Is Associated With the Macrophage Polarization and the Pathogenesis of Hepatocellular Carcinoma.,2022,10.3389/fimmu.2022.725595,https://pubmed.ncbi.nlm.nih.gov/35371096/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,36008864,Achaete-scute complex-like 2 regulated inflammatory mechanism through Toll-like receptor 4 activating in stomach adenocarcinoma.,2022,10.1186/s12957-022-02722-y,https://pubmed.ncbi.nlm.nih.gov/36008864/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,32059372,Disruption of Bone Zinc Metabolism during Postnatal Development of Rats after Early Life Exposure to Cadmium.,2020,10.3390/ijms21041218,https://pubmed.ncbi.nlm.nih.gov/32059372/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,30833875,Analysis of mRNA Expression Patterns in Peripheral Blood Cells of 3 Patients With Cancer After the First Fraction of 2 Gy Irradiation: An Integrated Case Report and Systematic Review.,2019,10.1177/1559325819833474,https://pubmed.ncbi.nlm.nih.gov/30833875/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,35049094,Stage-specific differential expression of zinc transporter SLC30A and SLC39A family proteins during prostate tumorigenesis.,2022,10.1002/mc.23382,https://pubmed.ncbi.nlm.nih.gov/35049094/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,26980500,Dietary zinc deficiency impairs humoral and cellular immune responses to BCG and ESAT-6/CFP-10 vaccination in offspring and adult rats.,2016,10.1016/j.tube.2016.01.002,https://pubmed.ncbi.nlm.nih.gov/26980500/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,34912040,Fe and Zn stress induced gene expression analysis unraveled mechanisms of mineral homeostasis in common bean (Phaseolus vulgaris L.).,2021,10.1038/s41598-021-03506-2,https://pubmed.ncbi.nlm.nih.gov/34912040/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,28596293,The uncoupling of autophagy and zinc homeostasis in airway epithelial cells as a fundamental contributor to COPD.,2017,10.1152/ajplung.00083.2017,https://pubmed.ncbi.nlm.nih.gov/28596293/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,28261762,Involvement of Zn Depletion in Cd-Induced Toxicity on Prenatal Bone Formation in Rat.,2017,10.1007/s12011-017-0981-7,https://pubmed.ncbi.nlm.nih.gov/28261762/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,28789614,Comparative transcriptome analysis reveals key cadmium transport-related genes in roots of two pak choi (Brassica rapa L. ssp. chinensis) cultivars.,2017,10.1186/s12864-017-3973-2,https://pubmed.ncbi.nlm.nih.gov/28789614/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,24649099,Expression analysis of zinc transporters in resting and stimulated human peripheral blood mononuclear cells.,2014,10.3892/br.2014.219,https://pubmed.ncbi.nlm.nih.gov/24649099/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,22079192,Intrathecally synthesized IgG in multiple sclerosis cerebrospinal fluid recognizes identical epitopes over time.,2011,10.1016/j.jneuroim.2011.10.009,https://pubmed.ncbi.nlm.nih.gov/22079192/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,18326752,Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors.,2008,10.1167/iovs.07-0781,https://pubmed.ncbi.nlm.nih.gov/18326752/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SHOC1,ENSG00000165181,Unsafe,12730457,Regulation of zinc metabolism and genomic outcomes.,2003,10.1093/jn/133.5.1521s,https://pubmed.ncbi.nlm.nih.gov/12730457/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42523917,"Neuroprotective potential of selenium nanoparticles and/or physical and mental activities against social isolation-induced depression in a rat model: inflammatory, oxidative stress, apoptotic, and neurotransmission modulatory pathways.",2026,10.3389/fphar.2026.1810142,https://pubmed.ncbi.nlm.nih.gov/42523917/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42420412,Multilevel brain heart interaction correlates with suicidal ideation in first episode drug naive major depressive disorder.,2026,10.1038/s42003-026-10524-1,https://pubmed.ncbi.nlm.nih.gov/42420412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42351195,Targeting microglial circMBNL1 unlocks a novel nanomedicine therapeutic strategy for major depressive disorder.,2026,10.1186/s12951-026-04734-2,https://pubmed.ncbi.nlm.nih.gov/42351195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42349491,Dose-volume histogram analysis of slit-beam irradiation: biological implications in mouse&lt;i&gt;ex vivo&lt;/i&gt;testes.,2026,10.1088/1361-6560/ae82b1,https://pubmed.ncbi.nlm.nih.gov/42349491/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42774820,"Combined Effects of Dietary Soybean Lecithin With Vitamin C or Inositol on Growth, Gonadal Development, and Intestinal Microbiota in Longsnout Catfish.",2026,10.1155/anu/4061190,https://pubmed.ncbi.nlm.nih.gov/42774820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42484082,Structural and Quantitative MRI Signal Features in Pediatric Focal Cortical Dysplasia: Clinical Relevance.,2026,,https://pubmed.ncbi.nlm.nih.gov/42484082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42064794,"Neuroprotective effects of rutin, sodium selenite, and rutin-conjugated selenium nanoparticles in a social isolation model.",2026,10.3389/fphar.2026.1782734,https://pubmed.ncbi.nlm.nih.gov/42064794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42474899,Investigating NF-κB as a biomarker for suicidal ideation in depression in a pilot case-control study.,2026,10.1007/s44192-026-00507-3,https://pubmed.ncbi.nlm.nih.gov/42474899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42633856,Abnormal gray matter structural covariance networks associated with suicidal ideation in adults with major depressive disorder: Evidence from the REST-meta-MDD consortium.,2026,10.1016/j.biopsycho.2026.109377,https://pubmed.ncbi.nlm.nih.gov/42633856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42007989,Unravelling mesenteric fibrosis in small intestinal neuroendocrine tumours and implications for clinical management.,2026,10.1530/erc-25-0116,https://pubmed.ncbi.nlm.nih.gov/42007989/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,41987324,Interleukins decrease epithelial protein and gene expression by K14 + CD105+ equine hoof progenitor cells.,2026,10.1186/s13287-026-05013-5,https://pubmed.ncbi.nlm.nih.gov/41987324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42498942,Reduced NK cell frequency in older patients with evolving fractures is linked to a distinct inflammatory cytokine profile.,2026,10.1186/s12979-026-00585-5,https://pubmed.ncbi.nlm.nih.gov/42498942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42294584,GPR124 Alleviates Blood-Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury.,2026,10.1002/advs.202501197,https://pubmed.ncbi.nlm.nih.gov/42294584/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42437849,From Gut to Fat: Intestinal Epithelial Exosomes Target PDGFRα&lt;sup&gt;+&lt;/sup&gt; Progenitors to Promote Lipogenesis and Counteract Subcutaneous Adipose Tissue Atrophy in Aging.,2026,10.1111/acel.70625,https://pubmed.ncbi.nlm.nih.gov/42437849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42632088,Major depressive disorder with preserved sexual interest represents a distinct subtype: results from resting-state fMRI.,2026,10.1093/jsxmed/qdag259,https://pubmed.ncbi.nlm.nih.gov/42632088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42452701,Body Composition Analysis in Young Patients with Recent Diagnosis of Multiple Sclerosis: An Exploratory Study.,2026,10.3390/jcm15135241,https://pubmed.ncbi.nlm.nih.gov/42452701/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42014385,Thalamocortical functional connectivity alterations and peripheral immune transcriptomic dysregulation in major depressive disorder patients with suicidal ideation.,2026,10.1038/s41398-026-04047-w,https://pubmed.ncbi.nlm.nih.gov/42014385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42166365,Multiomic analyses delineate human neuroendocrine tumor cell states in relation to normal enteroendocrine cell ontogeny.,2026,10.1172/jci197772,https://pubmed.ncbi.nlm.nih.gov/42166365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42750903,Concomitant parathyroid hormone-secreting oncocytic adrenocortical carcinoma and parathyroid adenoma.,2026,10.1210/jcemcr/luag253,https://pubmed.ncbi.nlm.nih.gov/42750903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42004955,Ferroptosis inhibition and AMPK activation: key mechanisms of soy isoflavones against cerebral injury.,2026,10.3389/fimmu.2026.1663986,https://pubmed.ncbi.nlm.nih.gov/42004955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,41816410,First-line therapies with maintenance regimens for driver gene-negative advanced non-small cell lung cancer (NSCLC): a systematic review and network meta-analysis of 61 randomized trials.,2026,10.21037/jtd-2025-aw-2087,https://pubmed.ncbi.nlm.nih.gov/41816410/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42807890,Alleviation of lead toxicity and enhancement of wheat (&lt;i&gt;Triticum aestivum&lt;/i&gt; L.) yield and antioxidant capacity using silicon and humic acid amendments in contaminated soil.,2026,10.1039/d6ra06967c,https://pubmed.ncbi.nlm.nih.gov/42807890/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42538573,CEUS with VEGFR2-targeted microbubbles for monitoring of early immunotherapy effects in a colorectal cancer model.,2026,10.1186/s40644-026-01101-0,https://pubmed.ncbi.nlm.nih.gov/42538573/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42601991,Bioinformatics-driven design and protective efficacy assessment of a multi-epitope vaccine for &lt;i&gt;Toxoplasma gondii&lt;/i&gt;.,2026,10.3389/fimmu.2026.1830954,https://pubmed.ncbi.nlm.nih.gov/42601991/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42917901,Discovery of a Broad-Spectrum Antiviral Compound against Porcine Reproductive and Respiratory Syndrome Virus.,2026,10.1021/acs.jmedchem.6c01783,https://pubmed.ncbi.nlm.nih.gov/42917901/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42751074,Growth outcomes following recombinant human growth hormone therapy in Zhu-Tokita-Takenouchi-Kim syndrome.,2026,10.1210/jcemcr/luag247,https://pubmed.ncbi.nlm.nih.gov/42751074/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,41685400,Hybrid lipoplex co-delivering siPD-L1/miR-140-5p reverses T cell exhaustion &lt;i&gt;via&lt;/i&gt; post-transcriptional regulation for &lt;i&gt;in situ&lt;/i&gt; photothermal vaccination.,2026,10.1039/d5nr05275k,https://pubmed.ncbi.nlm.nih.gov/41685400/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42107577,Artemisia sieversiana protein can induce allergic rhinitis and subsequent immune tolerance establishment.,2026,10.1016/j.ijbiomac.2026.152460,https://pubmed.ncbi.nlm.nih.gov/42107577/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42863746,Targeting the H3K4me3-HNRNPC-CD24 axis overcomes stemness and immunosuppression in hepatocellular carcinoma.,2026,10.1016/j.canlet.2026.218889,https://pubmed.ncbi.nlm.nih.gov/42863746/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42540242,"Evaluation of the Antiviral Activity of Monomeric, Dimeric, and Oligomeric Flavonoids against Chikungunya and Mayaro Viruses.",2026,10.1021/acsomega.6c02683,https://pubmed.ncbi.nlm.nih.gov/42540242/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42784355,&lt;i&gt;Enterococcus mundtii&lt;/i&gt; CRL35 as a Dual-Route Treatment for Cutaneous Leishmaniasis: Preclinical Safety and Efficacy Assessment.,2026,10.3390/tropicalmed11090256,https://pubmed.ncbi.nlm.nih.gov/42784355/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,40688666,Dendritic cell membrane-based DCsLipo@MnO&lt;sub&gt;2&lt;/sub&gt;@siCTLA4@PD-1α nanomedicine for the treatment of Lynch syndrome-related colorectal cancer.,2025,10.1016/j.mtbio.2025.102045,https://pubmed.ncbi.nlm.nih.gov/40688666/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42764087,Leukemic Stem Cell-Targeted Liposomal Nanoimmunotherapy Reverses Immune Evasion and Inhibits Fusion Oncoprotein-Driven Acute Myeloid Leukemia by Silencing B-Cell Lymphoma 2.,2026,10.1016/j.actbio.2026.09.035,https://pubmed.ncbi.nlm.nih.gov/42764087/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42745525,"New 1,3-Oxazole and 1,2,4-Oxadiazole Derivatives as Novel Agents Against Human Rhinovirus and Cytomegalovirus.",2026,10.1002/cmdc.70491,https://pubmed.ncbi.nlm.nih.gov/42745525/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42647025,Cross-Linked Chondroitin Sulfate Adhesion Barrier System in Open Rectal Resection: A Randomized Clinical Trial.,2026,10.1001/jamasurg.2026.3416,https://pubmed.ncbi.nlm.nih.gov/42647025/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,41891165,Non-clinical safety of novel cross-linked chondroitin sulfate (SI-449) as an anti-adhesion barrier for abdominal and pelvic surgeries.,2026,10.1177/08853282261432825,https://pubmed.ncbi.nlm.nih.gov/41891165/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42410871,Dual-responsive hydrogel-coated nanoclusters for combined magnetic hyperthermia and drug delivery: a comprehensive &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; toxicity profiling.,2026,10.1080/1061186x.2026.2697913,https://pubmed.ncbi.nlm.nih.gov/42410871/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,42779458,Fabrication of Protein A-Functionalized Silica-Encapsulated Carbon Dot Bioconjugates for Cellular Fluorescence Imaging.,2026,10.1002/bio.70627,https://pubmed.ncbi.nlm.nih.gov/42779458/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,41936264,Effects of neonatal Vitamin A supplementation on response to vaccinations in early infancy.,2026,10.1016/j.vaccine.2026.128551,https://pubmed.ncbi.nlm.nih.gov/41936264/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,41788020,A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.,2026,10.1158/2767-9764.crc-26-0010,https://pubmed.ncbi.nlm.nih.gov/41788020/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SI,ENSG00000090402,Unsafe,1677636,Expression of sucrase-isomaltase and dipeptidylpeptidase IV in human small intestine and colon.,1991,10.1016/0016-5085(91)90517-o,https://pubmed.ncbi.nlm.nih.gov/1677636/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,42662480,SIAH1-Mediated Ubiquitination and Degradation of TRIB3 Modulate Osteogenic and Adipogenic Differentiation.,2026,10.1155/sci/5507620,https://pubmed.ncbi.nlm.nih.gov/42662480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,42168988,Polyubiquitination and accumulation of PEG10 regulated by SIAH1/2 affiliates the progression of hepatocellular carcinoma.,2026,10.1186/s12964-026-02958-1,https://pubmed.ncbi.nlm.nih.gov/42168988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,42449076,The autoimmune regulator (AIRE) is a target of the E3-Ubiquitin ligase Seven-in-absentia homolog 1 (SIAH1).,2026,10.1007/s10495-026-02398-9,https://pubmed.ncbi.nlm.nih.gov/42449076/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,42666127,"OAF Blocks SIAH1-Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD.",2026,10.1002/advs.77451,https://pubmed.ncbi.nlm.nih.gov/42666127/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,41872127,TSG101 Promotes SIAH1 Auto-Ubiquitination to Drive Migration and Invasion in Hepatocellular Carcinoma Cells.,2026,10.1111/jcmm.71109,https://pubmed.ncbi.nlm.nih.gov/41872127/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,42294752,p300 Degradation by the p53-SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity.,2026,10.1002/advs.76101,https://pubmed.ncbi.nlm.nih.gov/42294752/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,41574050,A novel variant in &lt;i&gt;SIAH1&lt;/i&gt; associated with autosomal dominant Buratti-Harel syndrome.,2025,10.3389/fnins.2025.1677646,https://pubmed.ncbi.nlm.nih.gov/41574050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,41189745,Novel &lt;i&gt;SIAH1&lt;/i&gt; Frameshift Variant in a Chilean Patient With Buratti-Harel Syndrome.,2025,10.1155/crig/8822406,https://pubmed.ncbi.nlm.nih.gov/41189745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,38213136,Nrf2 Inhibits GAPDH/Siah1 Axis to Reduce Inflammatory Reactions and Proliferation of Microglia After Simulating Spinal Cord Injury.,2025,10.2174/0115665240280178231218093609,https://pubmed.ncbi.nlm.nih.gov/38213136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,41746912,Cell death modulation dictates tissue-specific tropism of lumpy skin disease virus.,2026,10.1371/journal.ppat.1013982,https://pubmed.ncbi.nlm.nih.gov/41746912/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,38961977,SIAH1 facilitates the migration and invasion of gastric cancer cells through promoting the ubiquitination and degradation of RECK.,2024,10.1016/j.heliyon.2024.e32676,https://pubmed.ncbi.nlm.nih.gov/38961977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,41062289,Dorsal determinant Hwa stabilizes β-catenin through direct inhibition of GSK3.,2026,10.1101/gad.352622.125,https://pubmed.ncbi.nlm.nih.gov/41062289/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,41573684,XPNPEP2 regulates angiogenesis via modulation of mitochondrial function through SLC25A6.,2025,10.3389/fcell.2025.1698651,https://pubmed.ncbi.nlm.nih.gov/41573684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,42257459,DRP1/p53 interaction-mediated mitochondrial regulation of TFRC-SLC39A14 drives mechanical overload-induced temporomandibular joint osteoarthritis via ferroptosis.,2026,10.1042/cs20260714,https://pubmed.ncbi.nlm.nih.gov/42257459/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,39075049,Deficiency of SIAH1 promotes the formation of filopodia by increasing the accumulation of FASN in liver cancer.,2024,10.1038/s41419-024-06929-7,https://pubmed.ncbi.nlm.nih.gov/39075049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,39344659,SIAH3 is frequently epigenetically silenced in cancer and regulates mitochondrial metabolism.,2025,10.1002/ijc.35202,https://pubmed.ncbi.nlm.nih.gov/39344659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,40371663,hTERT Increases TRF2 to Induce Telomere Compaction and Extend Cell Replicative Lifespan.,2025,10.1111/acel.70105,https://pubmed.ncbi.nlm.nih.gov/40371663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,40869369,CDK5 Inhibits Synphilin-1 Ubiquitination and Basal Mitophagy: Implications for Parkinson's Disease.,2025,10.3390/ijms26168048,https://pubmed.ncbi.nlm.nih.gov/40869369/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,40811061,Insect antiviral Mx-like protein forms biomolecular condensates to promote viral capsid ubiquitinated degradation.,2025,10.1016/j.celrep.2025.116146,https://pubmed.ncbi.nlm.nih.gov/40811061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,41488306,Decoding microbial carcinogenic strategies: ubiquitination and SUMO modification.,2025,10.3389/fmicb.2025.1720153,https://pubmed.ncbi.nlm.nih.gov/41488306/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,39695138,Targeting PPARγ via SIAH1/2-mediated ubiquitin-proteasomal degradation as a new therapeutic approach in luminal-type bladder cancer.,2024,10.1038/s41419-024-07298-x,https://pubmed.ncbi.nlm.nih.gov/39695138/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,38410210,Proteome-wide identification and functional analysis of ubiquitinated proteins in Hepa1-6 cells by knockdown of E3 ubiquitin ligase SIAH1.,2024,10.21037/tcr-23-124,https://pubmed.ncbi.nlm.nih.gov/38410210/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,37250786,Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation.,2023,10.1016/j.isci.2023.106852,https://pubmed.ncbi.nlm.nih.gov/37250786/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,38915423,Phase 1 Open-Label Study of Omigapil in Patients With LAMA2- or COL6-Related Dystrophy.,2024,10.1212/nxg.0000000000200148,https://pubmed.ncbi.nlm.nih.gov/38915423/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,31901813,Microcystins-LR induced apoptosis via S-nitrosylation of GAPDH in colorectal cancer cells.,2020,10.1016/j.ecoenv.2019.110096,https://pubmed.ncbi.nlm.nih.gov/31901813/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,36307912,SIAH proteins regulate the degradation and intra-mitochondrial aggregation of PINK1: Implications for mitochondrial pathology in Parkinson's disease.,2022,10.1111/acel.13731,https://pubmed.ncbi.nlm.nih.gov/36307912/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,39638883,Effects of surfactin stress on gene expression and pathological changes in Spodoptera litura.,2024,10.1038/s41598-024-81946-2,https://pubmed.ncbi.nlm.nih.gov/39638883/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,35524561,P-TEFb is degraded by Siah1/2 in quiescent cells.,2022,10.1093/nar/gkac291,https://pubmed.ncbi.nlm.nih.gov/35524561/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,36385010,Identification and validation of ubiquitin-proteasome system related genes as a prognostic signature for papillary renal cell carcinoma.,2022,10.18632/aging.204383,https://pubmed.ncbi.nlm.nih.gov/36385010/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,38017459,Targeting PEG10 as a novel therapeutic approach to overcome CDK4/6 inhibitor resistance in breast cancer.,2023,10.1186/s13046-023-02903-x,https://pubmed.ncbi.nlm.nih.gov/38017459/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,32252830,Characterization and functional analysis of SIAH1 during skin and hair follicle development in the angora rabbit (Oryctolagus cuniculus).,2020,10.1186/s41065-020-00126-0,https://pubmed.ncbi.nlm.nih.gov/32252830/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,36385558,Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy.,2022,10.1038/s12276-022-00878-x,https://pubmed.ncbi.nlm.nih.gov/36385558/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,33795634,Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation.,2021,10.1038/s41392-021-00556-w,https://pubmed.ncbi.nlm.nih.gov/33795634/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,33330480,Proteasome-Mediated Regulation of Cdhr1a by Siah1 Modulates Photoreceptor Development and Survival in Zebrafish.,2020,10.3389/fcell.2020.594290,https://pubmed.ncbi.nlm.nih.gov/33330480/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,12557228,SIAH1 inactivation correlates with tumor progression in hepatocellular carcinomas.,2003,10.1002/gcc.10170,https://pubmed.ncbi.nlm.nih.gov/12557228/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIAH1,ENSG00000196470,Unsafe,9403064,Characterization of human homologs of the Drosophila seven in absentia (sina) gene.,1997,10.1006/geno.1997.4997,https://pubmed.ncbi.nlm.nih.gov/9403064/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,42035126,Bispecific CD37-Siglec6 CAR‑T cells exhibit enhanced anti‑leukemic activity and reduced exhaustion in acute myeloid leukemia xenograft models.,2026,10.1186/s12967-026-08185-z,https://pubmed.ncbi.nlm.nih.gov/42035126/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,42600490,Sialic acid-binding immunoglobulin-like lectin-6 (SIGLEC6) is increased by hypoxia and inflammation in trophoblasts.,2026,10.1016/j.preghy.2026.101503,https://pubmed.ncbi.nlm.nih.gov/42600490/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,42250324,SIGLEC6 impairs trophoblast function and orchestrates macrophage M1 polarization via suppression of Akt signaling in early-onset preeclampsia.,2026,10.1016/j.placenta.2026.05.107,https://pubmed.ncbi.nlm.nih.gov/42250324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,42901778,Single-cell analysis reveals CXCL16&lt;sup&gt;+&lt;/sup&gt; dendritic cells and clonally expanded GZMK&lt;sup&gt;+&lt;/sup&gt; CD4 T cells driving joint inflammation in psoriatic arthritis.,2026,10.1002/art.70371,https://pubmed.ncbi.nlm.nih.gov/42901778/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,40737757,The association between circulating SIGLEC6 and preeclampsia: observational studies of seven cohorts.,2025,10.1016/j.ebiom.2025.105870,https://pubmed.ncbi.nlm.nih.gov/40737757/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,40436895,Siglec6 CAR T cells suppressed progression of AML via inhibiting Siglec6 and SHP2 induced Src and ERK signaling activation.,2025,10.1038/s41598-025-00456-x,https://pubmed.ncbi.nlm.nih.gov/40436895/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,42601952,Exploratory multi-omics analysis suggests context-dependent immune responses to vitamin D&lt;sub&gt;3&lt;/sub&gt; supplementation in PBMCs of multiple sclerosis patients.,2026,10.3389/fimmu.2026.1845005,https://pubmed.ncbi.nlm.nih.gov/42601952/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,42570703,Risk factors of clonal hematopoiesis of indeterminate potential.,2026,10.1016/j.clinme.2026.100635,https://pubmed.ncbi.nlm.nih.gov/42570703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,40742316,Pan-Cancer Analyses Refine the Single-Cell Portrait of Tumor-Infiltrating Dendritic Cells.,2025,10.1158/0008-5472.can-24-3595,https://pubmed.ncbi.nlm.nih.gov/40742316/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,38593870,Targeting inhibitory Siglec-3 to suppress IgE-mediated human basophil degranulation.,2024,10.1016/j.jaci.2024.03.020,https://pubmed.ncbi.nlm.nih.gov/38593870/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,39417994,The lifespan and kinetics of human dendritic cell subsets and their precursors in health and inflammation.,2024,10.1084/jem.20220867,https://pubmed.ncbi.nlm.nih.gov/39417994/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,41680500,Protein networks are influenced by maternal BMI and differentiate preterm birth types.,2026,10.1038/s43856-026-01376-1,https://pubmed.ncbi.nlm.nih.gov/41680500/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,41031401,Large-Scale Proteomics Reveals New Candidate Biomarkers for Late-Onset Preeclampsia.,2026,10.1161/hypertensionaha.125.25189,https://pubmed.ncbi.nlm.nih.gov/41031401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,38894741,Unveiling immune tolerance pathways in preeclampsia placenta: implications for molecular targets and discovery of potential biomarkers.,2024,10.3389/fendo.2024.1385154,https://pubmed.ncbi.nlm.nih.gov/38894741/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,40991151,Proteome-Wide Mendelian Randomisation Study of Adverse Perinatal Outcomes.,2025,10.1007/s10519-025-10233-1,https://pubmed.ncbi.nlm.nih.gov/40991151/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,41624379,Convergent Multistage Evidence Implicates the CCR2-Artemin Immune-Inflammation Axis in Acute Myeloid Leukemia.,2026,10.1155/mi/2476470,https://pubmed.ncbi.nlm.nih.gov/41624379/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,39342548,Exploring a new signature for lung adenocarcinoma: analyzing cuproptosis-related genes through Integrated single-cell and bulk RNA sequencing.,2024,10.1007/s12672-024-01389-z,https://pubmed.ncbi.nlm.nih.gov/39342548/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,36113626,Elevated trophoblastic Siglec6 contributes to the impairment of vascular endothelial cell functions by downregulating Wnt6/β-catenin signaling in preeclampsia.,2022,10.1016/j.abb.2022.109396,https://pubmed.ncbi.nlm.nih.gov/36113626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,37840671,Complement Regulatory Protein CD46 Manifests a Unique Role in Promoting the Migration of Bladder Cancer Cells.,2023,10.4068/cmj.2023.59.3.160,https://pubmed.ncbi.nlm.nih.gov/37840671/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,38099221,A cross-sectional analysis of syncytiotrophoblast membrane extracellular vesicles-derived transcriptomic biomarkers in early-onset preeclampsia.,2023,10.3389/fcvm.2023.1291642,https://pubmed.ncbi.nlm.nih.gov/38099221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,39083932,SLC4A4 as a novel biomarker involved in immune system response and lung adenocarcinoma progression.,2024,10.1016/j.intimp.2024.112756,https://pubmed.ncbi.nlm.nih.gov/39083932/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,37414380,AXL+SIGLEC6+ dendritic cells in cerebrospinal fluid and brain tissues of patients with autoimmune inflammatory demyelinating disease of CNS.,2023,10.1016/j.clim.2023.109686,https://pubmed.ncbi.nlm.nih.gov/37414380/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,37974107,Characterization of genomic instability-related genes predicts survival and therapeutic response in lung adenocarcinoma.,2023,10.1186/s12885-023-11580-0,https://pubmed.ncbi.nlm.nih.gov/37974107/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,33633313,Siglec-6 is a target for chimeric antigen receptor T-cell treatment of chronic lymphocytic leukemia.,2021,10.1038/s41375-021-01188-3,https://pubmed.ncbi.nlm.nih.gov/33633313/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,34975867,Colorectal Cancer-Associated Immune Exhaustion Involves T and B Lymphocytes and Conventional NK Cells and Correlates With a Shorter Overall Survival.,2021,10.3389/fimmu.2021.778329,https://pubmed.ncbi.nlm.nih.gov/34975867/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,35101945,Generation of cDC-like cells from human induced pluripotent stem cells via Notch signaling.,2022,10.1136/jitc-2021-003827,https://pubmed.ncbi.nlm.nih.gov/35101945/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIGLEC6,ENSG00000105492,Unsafe,33796453,Integrative Analysis of the Expression of SIGLEC Family Members in Lung Adenocarcinoma via Data Mining.,2021,10.3389/fonc.2021.608113,https://pubmed.ncbi.nlm.nih.gov/33796453/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,41285899,Multi-ancestry investigation of the genomics of erectile dysfunction.,2025,10.1038/s41467-025-66723-7,https://pubmed.ncbi.nlm.nih.gov/41285899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,41495897,Multimodal bHLH-PAS DNA binding controls specificity and drives obesity.,2026,10.1093/nar/gkaf1352,https://pubmed.ncbi.nlm.nih.gov/41495897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,41516406,Novel &lt;i&gt;SIM1&lt;/i&gt; Variants Expanding the Spectrum of SIM1-Related Obesity.,2026,10.3390/ijms27010533,https://pubmed.ncbi.nlm.nih.gov/41516406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,39700135,Growth hormone receptor in VGLUT2 or Sim1 cells regulates glycemia and insulin sensitivity.,2024,10.1073/pnas.2407225121,https://pubmed.ncbi.nlm.nih.gov/39700135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,41751424,Exploring Autosomal Dominant Non-Syndromic Monogenic Obesity: From Genes to Therapy.,2026,10.3390/cimb48020162,https://pubmed.ncbi.nlm.nih.gov/41751424/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,40343416,Effects of targeted deletion of a 284 bp avian-specific highly conserved element within the Sim1 gene on flight feather development in chickens.,2025,10.24272/j.issn.2095-8137.2024.343,https://pubmed.ncbi.nlm.nih.gov/40343416/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,41581146,A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types.,2026,10.1016/j.celrep.2025.116904,https://pubmed.ncbi.nlm.nih.gov/41581146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,41257561,Genetic and epigenetic markers in the METTL21C gene associated with umbilical hernia in pigs.,2025,10.1186/s12864-025-12315-0,https://pubmed.ncbi.nlm.nih.gov/41257561/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,42844274,CBX4 stabilizes NEUROD1 through SUMO-ubiquitin crosstalk to delay β-cell senescence.,2026,10.1038/s41467-026-77536-7,https://pubmed.ncbi.nlm.nih.gov/42844274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,40428410,Cumulative Effects of Genetic Variants Detected in a Child with Early-Onset Non-Syndromic Obesity Due to SIM-1 Gene Mutation.,2025,10.3390/genes16050588,https://pubmed.ncbi.nlm.nih.gov/40428410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,40449730,Uncovering the role of Gpr45 in obesity regulation.,2025,10.1016/j.molmet.2025.102174,https://pubmed.ncbi.nlm.nih.gov/40449730/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,40943369,Genetic Prediction of Erectile Dysfunction Caused by Statins Among Malaysian Cardiac Patients.,2025,10.3390/ijms26178447,https://pubmed.ncbi.nlm.nih.gov/40943369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,40250420,CD36-mediated endocytosis of proteolysis-targeting chimeras.,2025,10.1016/j.cell.2025.03.036,https://pubmed.ncbi.nlm.nih.gov/40250420/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,39201344,Computational Analyses Reveal Deregulated Clock Genes Associated with Breast Cancer Development in Night Shift Workers.,2024,10.3390/ijms25168659,https://pubmed.ncbi.nlm.nih.gov/39201344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,42547334,Genetic burden of rare leptin-melanocortin variants in pediatric nonsyndromic obesity: Evidence from a Taiwanese cohort.,2026,10.1016/j.orcp.2026.07.003,https://pubmed.ncbi.nlm.nih.gov/42547334/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,37033219,Melanocortin 4 receptor signaling in Sim1 neurons permits sexual receptivity in female mice.,2023,10.3389/fendo.2023.983670,https://pubmed.ncbi.nlm.nih.gov/37033219/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,39019033,Rare variation in non-coding regions with evolutionary signatures contributes to autism spectrum disorder risk.,2024,10.1016/j.xgen.2024.100609,https://pubmed.ncbi.nlm.nih.gov/39019033/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,42883772,"A Batch-Aware, Subject-Grouped Pipeline to Prioritize HIIT-Associated DNA Methylation Candidates with Cross-Cohort Evaluation in Skeletal Muscle.",2026,10.3390/ijms27198523,https://pubmed.ncbi.nlm.nih.gov/42883772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,41094176,Updated penetrance estimates for recurrent copy number variants - an improved definition and formula.,2026,10.1038/s41431-025-01948-0,https://pubmed.ncbi.nlm.nih.gov/41094176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,42499770,"Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management.",2026,10.1002/ped4.70040,https://pubmed.ncbi.nlm.nih.gov/42499770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,40521184,SUMOylation of SARS-CoV-2 spike protein is a key target for broad-spectrum antiviral therapy.,2025,10.7150/thno.111256,https://pubmed.ncbi.nlm.nih.gov/40521184/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,39392390,Cell class-specific long-range axonal projections of neurons in mouse whisker-related somatosensory cortices.,2024,10.7554/elife.97602,https://pubmed.ncbi.nlm.nih.gov/39392390/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,34788630,Gαi/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents.,2021,10.1016/j.celrep.2021.109997,https://pubmed.ncbi.nlm.nih.gov/34788630/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,30879785,The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits.,2019,10.1016/j.neuron.2019.02.028,https://pubmed.ncbi.nlm.nih.gov/30879785/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,30583798,GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology.,2019,10.1016/j.ajhg.2018.11.004,https://pubmed.ncbi.nlm.nih.gov/30583798/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,31803919,Metabolic Effects of Oxytocin.,2020,10.1210/endrev/bnz012,https://pubmed.ncbi.nlm.nih.gov/31803919/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,28472148,Genetic analysis of single-minded 1 gene in early-onset severely obese children and adolescents.,2017,10.1371/journal.pone.0177222,https://pubmed.ncbi.nlm.nih.gov/28472148/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,37372363,Identifying Candidate Genes for Litter Size and Three Morphological Traits in Youzhou Dark Goats Based on Genome-Wide SNP Markers.,2023,10.3390/genes14061183,https://pubmed.ncbi.nlm.nih.gov/37372363/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,35654930,Effects of Heterozygous Variants in the Leptin-Melanocortin Pathway on Roux-en-Y Gastric Bypass Outcomes: a 15-Year Case-Control Study.,2022,10.1007/s11695-022-06122-9,https://pubmed.ncbi.nlm.nih.gov/35654930/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,28003815,Degranulation Response in Cytotoxic Rat Lymphocytes Measured with a Novel CD107a Antibody.,2016,10.3389/fimmu.2016.00572,https://pubmed.ncbi.nlm.nih.gov/28003815/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,31839450,Fan Cells in Layer 2 of the Lateral Entorhinal Cortex Are Critical for Episodic-like Memory.,2020,10.1016/j.cub.2019.11.027,https://pubmed.ncbi.nlm.nih.gov/31839450/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,28422779,The Utility of High-Fidelity Simulation for Training Critical Care Fellows in the Management of Extracorporeal Membrane Oxygenation Emergencies: A Randomized Controlled Trial.,2017,10.1097/ccm.0000000000002437,https://pubmed.ncbi.nlm.nih.gov/28422779/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,30218172,DNA methylation marker to estimate the breast cancer cell fraction in DNA samples.,2018,10.1007/s12032-018-1207-3,https://pubmed.ncbi.nlm.nih.gov/30218172/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,24465507,Cell morphogenesis proteins are translationally controlled through UTRs by the Ndr/LATS target Ssd1.,2014,10.1371/journal.pone.0085212,https://pubmed.ncbi.nlm.nih.gov/24465507/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIM1,ENSG00000112246,Unsafe,26098212,Estrogen receptor-α in medial amygdala neurons regulates body weight.,2015,10.1172/jci80941,https://pubmed.ncbi.nlm.nih.gov/26098212/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIRPD,ENSG00000125900,Unsafe,42693206,THE1 repeats: Ancient endogenous retroviruses rampaging behind sarcoid myopathy.,2026,10.1038/s10038-026-01510-w,https://pubmed.ncbi.nlm.nih.gov/42693206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIRPD,ENSG00000125900,Unsafe,41617774,Identification of diagnostic and prognostic biomarkers in lung adenocarcinoma through integrated bioinformatics analysis and real time PCR validation.,2026,10.1038/s41598-026-35971-y,https://pubmed.ncbi.nlm.nih.gov/41617774/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIRPD,ENSG00000125900,Unsafe,41443549,"Urinary total arsenic, arsenic species, and arsenic methylation capacity: an integrative profiling analysis of microRNAs in plasma and leukocytes.",2026,10.1016/j.envpol.2025.127574,https://pubmed.ncbi.nlm.nih.gov/41443549/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIRPD,ENSG00000125900,Unsafe,39920152,Retrotrans-genomics identifies aberrant THE1B endogenous retrovirus fusion transcripts in the pathogenesis of sarcoidosis.,2025,10.1038/s41467-025-56567-6,https://pubmed.ncbi.nlm.nih.gov/39920152/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIRPD,ENSG00000125900,Unsafe,37383227,Gut microbiota and Sjögren's syndrome: a two-sample Mendelian randomization study.,2023,10.3389/fimmu.2023.1187906,https://pubmed.ncbi.nlm.nih.gov/37383227/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIRPD,ENSG00000125900,Unsafe,27058892,Read-through transcripts in normal human lung parenchyma are down-regulated in lung adenocarcinoma.,2016,10.18632/oncotarget.8556,https://pubmed.ncbi.nlm.nih.gov/27058892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIRPD,ENSG00000125900,Unsafe,28480134,Common and rare genetic markers of lipid variation in subjects with type 2 diabetes from the ACCORD clinical trial.,2017,10.7717/peerj.3187,https://pubmed.ncbi.nlm.nih.gov/28480134/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,41937268,The Transcription Factors Six3 and Six6 in Neuromedin-S Neurons Differentially Affect Circadian Rhythms.,2026,10.1002/jnr.70123,https://pubmed.ncbi.nlm.nih.gov/41937268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,41533905,"Genetic Link Across Species: SIX6, a Major Human Glaucoma Gene, Confers Susceptibility to Glaucoma in Shiba-Inu Dogs.",2026,10.1167/iovs.67.1.5,https://pubmed.ncbi.nlm.nih.gov/41533905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,42472310,Temporal Comparison Reveals Weakened Genotype-Phenotype Association at a Major-Effect Locus in Dworshak National Fish Hatchery Steelhead.,2026,10.1111/eva.70300,https://pubmed.ncbi.nlm.nih.gov/42472310/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,42265999,The Effector SIX8 Contributes to Virulence of Fusarium oxysporum f. sp. lactucae Race 4 on Lettuce.,2026,10.1111/mpp.70296,https://pubmed.ncbi.nlm.nih.gov/42265999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,42713962,Connecting Skin and Gut in Dermatitis Herpetiformis: Insights from Gluten Challenge Transcriptomics.,2026,10.2340/actadv.v106.adv-2026-0792,https://pubmed.ncbi.nlm.nih.gov/42713962/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,41892811,SIX3 as a Regulator of Development and Disease.,2026,10.3390/jdb14010013,https://pubmed.ncbi.nlm.nih.gov/41892811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,42506237,Involvement of &lt;i&gt;SIX9&lt;/i&gt; in Growth and Pathogenicity in &lt;i&gt;Fusarium oxysporum&lt;/i&gt; f. sp. &lt;i&gt;fragariae&lt;/i&gt;.,2026,10.3390/jof12070475,https://pubmed.ncbi.nlm.nih.gov/42506237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,41958162,Differential Pathogenicity and Secreted in Xylem Gene Patterns in Fusarium spp. Causing Onion Basal Rot.,2026,10.5423/ppj.oa.08.2025.0115,https://pubmed.ncbi.nlm.nih.gov/41958162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,41894275,Genetic associations of variants in 10 glaucoma-related genes with POAG risk and structural phenotypes in Korean subjects.,2026,10.1097/md.0000000000048106,https://pubmed.ncbi.nlm.nih.gov/41894275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,42670983,Temporal Inflammatory Profile in Skin Surface after Oronasal Mask Application.,2026,10.2340/actadv.v106.adv-2025-0159,https://pubmed.ncbi.nlm.nih.gov/42670983/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,42042359,Pathogenicity and Pre-Characterised Putative Effectors of &lt;i&gt;Fusarium oxysporum&lt;/i&gt; and &lt;i&gt;F. proliferatum&lt;/i&gt; in Garlic (&lt;i&gt;Allium sativum&lt;/i&gt;) and Other &lt;i&gt;Allium&lt;/i&gt; spp.,2026,10.3390/jof12040264,https://pubmed.ncbi.nlm.nih.gov/42042359/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,41482736,"Density-Dependent Expression of Epitranscriptomic, Stress and Appetite Regulating Genes in Atlantic Salmon.",2026,10.1111/mec.70230,https://pubmed.ncbi.nlm.nih.gov/41482736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,41211298,Investigating the Shared Genetic Architecture of 3 Age-Related Ocular Disorders.,2026,10.1016/j.xops.2025.100942,https://pubmed.ncbi.nlm.nih.gov/41211298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,40576883,The role of SIX6 gene in juvenile open-angle glaucoma: a subtle contributor to the mutational landscape.,2025,10.1007/s10384-025-01233-z,https://pubmed.ncbi.nlm.nih.gov/40576883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,41619599,Behavioral toxicity of tralopyril in Oryzias melastigma: Integrated consequences of multi-organ damage and thyroid hormone dysregulation.,2026,10.1016/j.jhazmat.2026.141304,https://pubmed.ncbi.nlm.nih.gov/41619599/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,41002292,In Silico Identification of Pathogenicity Effectors on &lt;i&gt;Fusarium oxysporum&lt;/i&gt; f. sp. &lt;i&gt;vanillae&lt;/i&gt;.,2025,10.3390/biotech14030050,https://pubmed.ncbi.nlm.nih.gov/41002292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,40129747,Optimization of a CRISPR-Cas9 &lt;i&gt;in vitro&lt;/i&gt; protocol for targeting the SIX9 gene of &lt;i&gt;Fusarium oxysporum&lt;/i&gt; f.sp. &lt;i&gt;cubense&lt;/i&gt; race 1 associated with banana Fusarium wilt.,2025,10.3389/fpls.2025.1523884,https://pubmed.ncbi.nlm.nih.gov/40129747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,39446806,Six3 and Six6 jointly control diverse target genes in multiple cell populations over developmental trajectories of mouse embryonic retinal progenitor cells.,2024,10.1371/journal.pone.0308839,https://pubmed.ncbi.nlm.nih.gov/39446806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,39867730,Sine oculis homeobox homolog family function in gastrointestinal cancer: Progression and comprehensive analysis.,2025,10.5306/wjco.v16.i1.97163,https://pubmed.ncbi.nlm.nih.gov/39867730/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,41563720,The &lt;i&gt;SGE1&lt;/i&gt; Homolog of &lt;i&gt;Fusarium oxysporum&lt;/i&gt; f. sp. &lt;i&gt;rapae&lt;/i&gt; Is a Pathogenicity Factor and Required for Full Stress Resistance of Chlamydospores.,2026,10.1094/phyto-08-25-0279-r,https://pubmed.ncbi.nlm.nih.gov/41563720/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,42775869,The Use of Systemic Immunomodulating Drugs and Management Practices in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis among Dermatologists in the Philippines: A Cross-sectional Survey Study.,2026,10.2340/actadv.v106.adv-2026-0499,https://pubmed.ncbi.nlm.nih.gov/42775869/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,39482785,Amlodipine increases risk of primary open-angle glaucoma.,2024,10.1186/s40885-024-00290-9,https://pubmed.ncbi.nlm.nih.gov/39482785/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,39940984,Vitamin E Mitigates Polystyrene-Nanoplastic-Induced Visual Dysfunction in Zebrafish Larvae.,2025,10.3390/ijms26031216,https://pubmed.ncbi.nlm.nih.gov/39940984/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,41230783,Advances in the genetics of refractive errors: Contributions from the CREAM consortium.,2026,10.1111/aos.70025,https://pubmed.ncbi.nlm.nih.gov/41230783/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,33897626,Identification and Expression of Secreted In Xylem Pathogenicity Genes in Fusarium oxysporum f. sp. pisi.,2021,10.3389/fmicb.2021.593140,https://pubmed.ncbi.nlm.nih.gov/33897626/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,38186275,Tissue-specific metabolic enzyme levels covary with whole-animal metabolic rates and life-history loci via epistatic effects.,2024,10.1098/rstb.2022.0482,https://pubmed.ncbi.nlm.nih.gov/38186275/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,32835548,SIX6 is a TAL1-regulated transcription factor in T-ALL and associated with inferior outcome.,2020,10.1080/10428194.2020.1804560,https://pubmed.ncbi.nlm.nih.gov/32835548/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,40650499,Genetic Recovery of Two Wild Seatrout Populations Following Long-Term Stocking With Non-Native Conspecifics.,2025,10.1111/mec.70036,https://pubmed.ncbi.nlm.nih.gov/40650499/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,39779741,SIX1 aggravates the progression of spinal cord injury in mice by promoting M1 polarization of microglia.,2025,10.1038/s41598-024-82121-3,https://pubmed.ncbi.nlm.nih.gov/39779741/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,39452667,Assessing the Pathogenicity of Berkeleyomyces rouxiae and Fusarium oxysporum f. sp. vasinfectum on Cotton (Gossypium hirsutum) Using a Rapid and Robust Seedling Screening Method.,2024,10.3390/jof10100715,https://pubmed.ncbi.nlm.nih.gov/39452667/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,37221451,Propensity of Patient-Derived iPSCs for Retinal Differentiation: Implications for Autologous Cell Replacement.,2023,10.1093/stcltm/szad028,https://pubmed.ncbi.nlm.nih.gov/37221451/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,36553630,A Tet-Inducible CRISPR Platform for High-Fidelity Editing of Human Pluripotent Stem Cells.,2022,10.3390/genes13122363,https://pubmed.ncbi.nlm.nih.gov/36553630/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,36096985,Direct conversion of human umbilical cord mesenchymal stem cells into retinal pigment epithelial cells for treatment of retinal degeneration.,2022,10.1038/s41419-022-05199-5,https://pubmed.ncbi.nlm.nih.gov/36096985/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SIX6,ENSG00000184302,Unsafe,25915183,Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development.,2015,10.1210/me.2014-1279,https://pubmed.ncbi.nlm.nih.gov/25915183/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,42909751,SKA1 plays a tumor-promoting role in colorectal cancer: coupling TAF1‑dependent transcription with RPL8 interaction.,2026,10.1007/s11010-026-05758-w,https://pubmed.ncbi.nlm.nih.gov/42909751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,40874684,Knocking Down SKA1 Inhibits Hepatocellular Carcinoma Progression via Apoptosis: Integrating Single-Cell Transcriptomics With In Vivo and In Vitro Validation.,2025,10.1002/biof.70044,https://pubmed.ncbi.nlm.nih.gov/40874684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,39697720,SKA1/2/3 link to poor prognosis and immune infiltration of head and neck squamous cell carcinomas.,2024,10.21037/tcr-24-862,https://pubmed.ncbi.nlm.nih.gov/39697720/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,42625886,&lt;i&gt;Atractylodes chinensis&lt;/i&gt; polysaccharides downregulate RHEB to confer splenoprotective effects against aging-associated disorders.,2026,10.3389/fphar.2026.1877665,https://pubmed.ncbi.nlm.nih.gov/42625886/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,39614199,SKA1/2/3 is a prognostic and predictive biomarker in esophageal adenocarcinoma and squamous cell carcinoma.,2024,10.1186/s12885-024-13257-8,https://pubmed.ncbi.nlm.nih.gov/39614199/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,39656562,"SKA1 promotes oncogenic properties in oral dysplasia and oral squamous cell carcinoma, and augments resistance to radiotherapy.",2025,10.1002/1878-0261.13780,https://pubmed.ncbi.nlm.nih.gov/39656562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,37814813,Preliminary exploration of SKA1 expression in lung adenocarcinoma and its clinical significance.,2023,10.3724/abbs.2023243,https://pubmed.ncbi.nlm.nih.gov/37814813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,37746945,Integrated analysis of SKA1-related ceRNA network and SKA1 immunoassays in HCC: A study based on bioinformatic.,2023,10.1097/md.0000000000034826,https://pubmed.ncbi.nlm.nih.gov/37746945/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,41862644,Microtubule end stabilisation by cooperative oligomers of Ska and Ndc80 complexes.,2026,10.1038/s44318-026-00749-5,https://pubmed.ncbi.nlm.nih.gov/41862644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,42160554,Tissue expression of SKA1 (Spindle kinetochore-associated complex 1) in oral cancers and oral potentially malignant disorders: An association with disease progression.,2026,10.47391/jpma.22972,https://pubmed.ncbi.nlm.nih.gov/42160554/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,38507172,LINC00963 Promotes Cisplatin Resistance in Esophageal Squamous Cell Carcinoma by Interacting with miR-10a to Upregulate SKA1 Expression.,2024,10.1007/s12010-024-04897-4,https://pubmed.ncbi.nlm.nih.gov/38507172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,37017853,Integrative Analysis of DNA Methylation and Gene Expression Data Identifies Potential Biomarkers and Functional Epigenetic Modules for SARS-CoV-2.,2023,10.1007/s10528-023-10373-1,https://pubmed.ncbi.nlm.nih.gov/37017853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,36439516,SKA1/2/3 is a biomarker of poor prognosis in human hepatocellular carcinoma.,2022,10.3389/fonc.2022.1038925,https://pubmed.ncbi.nlm.nih.gov/36439516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,36973749,Hypoxia-induced lncRNA MRVI1-AS1 accelerates hepatocellular carcinoma progression by recruiting RNA-binding protein CELF2 to stabilize SKA1 mRNA.,2023,10.1186/s12957-023-02993-z,https://pubmed.ncbi.nlm.nih.gov/36973749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,37265445,The Ndc80-Cdt1-Ska1 complex is a central processive kinetochore-microtubule coupling unit.,2023,10.1083/jcb.202208018,https://pubmed.ncbi.nlm.nih.gov/37265445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,36462498,SKA1 promotes tumor metastasis via SAFB-mediated transcription repression of DUSP6 in clear cell renal cell carcinoma.,2022,10.18632/aging.204418,https://pubmed.ncbi.nlm.nih.gov/36462498/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,36397719,SKA1 is overexpressed in laryngocarcinoma and modulates cell growth via P53 signaling pathway.,2023,10.1080/15384101.2022.2145817,https://pubmed.ncbi.nlm.nih.gov/36397719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,40109869,The regulatory role of &lt;i&gt;ZFAS1/&lt;/i&gt;miRNAs/mRNAs axis in cancer: a systematic review.,2025,10.32604/or.2024.050548,https://pubmed.ncbi.nlm.nih.gov/40109869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,35813298,ETV5 overexpression promotes progression of esophageal squamous cell carcinoma by upregulating SKA1 and TRPV2.,2022,10.7150/ijms.71892,https://pubmed.ncbi.nlm.nih.gov/35813298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,35095717,Overexpression of SKA Complex Is Associated With Poor Prognosis in Gliomas.,2021,10.3389/fneur.2021.755681,https://pubmed.ncbi.nlm.nih.gov/35095717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,37180139,Immunological role and prognostic value of the SKA family in pan-cancer analysis.,2023,10.3389/fimmu.2023.1012999,https://pubmed.ncbi.nlm.nih.gov/37180139/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,40523001,Cell cycle dependent methylation of Dam1 contributes to kinetochore integrity and faithful chromosome segregation.,2025,10.1371/journal.pgen.1011760,https://pubmed.ncbi.nlm.nih.gov/40523001/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,34845974,Integrative analysis of prognostic value and immune infiltration of spindle and kinetochore-associated family members in breast cancer.,2021,10.1080/21655979.2021.1995576,https://pubmed.ncbi.nlm.nih.gov/34845974/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,33224872,Identification of Spindle and Kinetochore-Associated Family Genes as Therapeutic Targets and Prognostic Biomarkers in Pancreas Ductal Adenocarcinoma Microenvironment.,2020,10.3389/fonc.2020.553536,https://pubmed.ncbi.nlm.nih.gov/33224872/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,32232899,SKA1 regulates actin cytoskeleton remodelling via activating Cdc42 and influences the migration of pancreatic ductal adenocarcinoma cells.,2020,10.1111/cpr.12799,https://pubmed.ncbi.nlm.nih.gov/32232899/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,34045512,Transcript levels of spindle and kinetochore-associated complex 1/3 as prognostic biomarkers correlated with immune infiltrates in hepatocellular carcinoma.,2021,10.1038/s41598-021-89628-z,https://pubmed.ncbi.nlm.nih.gov/34045512/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,32420061,SKA1/2/3 serves as a biomarker for poor prognosis in human lung adenocarcinoma.,2020,10.21037/tlcr.2020.01.20,https://pubmed.ncbi.nlm.nih.gov/32420061/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,36062274,Spindle and Kinetochore-associated Family Genes are Prognostic and Predictive Biomarkers in Hepatocellular Carcinoma.,2022,10.14218/jcth.2021.00216,https://pubmed.ncbi.nlm.nih.gov/36062274/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,35949842,Construction and validation of a novel prediction system for detection of overall survival in lung cancer patients.,2022,10.12998/wjcc.v10.i18.5984,https://pubmed.ncbi.nlm.nih.gov/35949842/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,37639469,Genetic enhancers of partial PLK1 inhibition reveal hypersensitivity to kinetochore perturbations.,2023,10.1371/journal.pgen.1010903,https://pubmed.ncbi.nlm.nih.gov/37639469/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,30537941,SKA1 overexpression is associated with poor prognosis in hepatocellular carcinoma.,2018,10.1186/s12885-018-5119-6,https://pubmed.ncbi.nlm.nih.gov/30537941/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,32923148,Identification of tumor-infiltrating immune cells and prognostic validation of tumor-infiltrating mast cells in adrenocortical carcinoma: results from bioinformatics and real-world data.,2020,10.1080/2162402x.2020.1784529,https://pubmed.ncbi.nlm.nih.gov/32923148/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,35559045,Assessing the Potential Prognostic and Immunological Role of TK1 in Prostate Cancer.,2022,10.3389/fgene.2022.778850,https://pubmed.ncbi.nlm.nih.gov/35559045/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,30588253,"OIP5 Promotes Growth, Metastasis and Chemoresistance to Cisplatin in Bladder Cancer Cells.",2018,10.7150/jca.27381,https://pubmed.ncbi.nlm.nih.gov/30588253/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA1,ENSG00000154839,Unsafe,34840632,Construction and Comprehensive Analysis of a Stratification System Based on AGTRAP in Patients with Hepatocellular Carcinoma.,2021,10.1155/2021/6144476,https://pubmed.ncbi.nlm.nih.gov/34840632/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,42457653,BAP1 deficiency-induced SKA3 promotes clear cell renal cell carcinoma malignant progression by regulating chromosomal instability.,2026,10.1038/s41419-026-09076-3,https://pubmed.ncbi.nlm.nih.gov/42457653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,42170427,SKA3 promotes cell growth and metastasis and is associated with poor prognosis in patients with esophageal cancer.,2026,10.62347/kydp3214,https://pubmed.ncbi.nlm.nih.gov/42170427/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,42077186,Transcriptional Activation of SKA3 by SOX9 Promotes the Malignant Progression of Laryngeal Squamous Cell Carcinoma by Regulating AKR1C1.,2026,10.1002/jbt.70874,https://pubmed.ncbi.nlm.nih.gov/42077186/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,42079738,Integrated analysis identifies a palmitoylation-associated prognostic model (ACSM5/SKA3) for lung adenocarcinoma across multiple cohorts.,2026,10.7717/peerj.21160,https://pubmed.ncbi.nlm.nih.gov/42079738/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,41298345,SKA3-mediated hypoxia tolerance and metabolic reprogramming promote liver metastasis in lung adenocarcinoma.,2025,10.1038/s41419-025-08270-z,https://pubmed.ncbi.nlm.nih.gov/41298345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,40642599,Chitosan-encapsulated &lt;i&gt;Gloriosa superba&lt;/i&gt; nanoparticles suppress cervical cancer by inhibiting SKA3-mediated PI3K/AKT/mTOR pathway.,2025,10.1007/s10616-025-00809-4,https://pubmed.ncbi.nlm.nih.gov/40642599/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,38791174,SKA3 Expression as a Prognostic Factor for Patients with Pancreatic Adenocarcinoma.,2024,10.3390/ijms25105134,https://pubmed.ncbi.nlm.nih.gov/38791174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,40237052,lncRNAs and circRNAs: Emerging Players in Pediatric Medulloblastoma Pathology.,2026,10.2174/0109298673354413250325073924,https://pubmed.ncbi.nlm.nih.gov/40237052/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,40007126,Pan-Cancer Analysis Reveals SKA3 as a Potential Diagnostic and Prognostic Biomarker.,2025,10.1111/apm.70009,https://pubmed.ncbi.nlm.nih.gov/40007126/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,41079598,Comparative bioinformatics analysis of the Wnt pathway in breast cancer: Selection of novel biomarker panels associated with ER status.,2025,10.1515/biol-2025-1173,https://pubmed.ncbi.nlm.nih.gov/41079598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,40056339,SKA3 promotes lung adenocarcinoma progression via the EGFR/E2F1/SKA3/integrin β1 signaling loop.,2025,10.1007/s11010-025-05242-x,https://pubmed.ncbi.nlm.nih.gov/40056339/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,38241327,SKA3 targeted therapies in cancer precision surgery: bridging bench discoveries to clinical applications - review article.,2024,10.1097/js9.0000000000001123,https://pubmed.ncbi.nlm.nih.gov/38241327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,42072359,Integrative Whole-Genome and Epigenome Profiling of cfDNA in Familial Prostate Cancer: Insights from a Pilot Study.,2026,10.3390/biomedicines14040818,https://pubmed.ncbi.nlm.nih.gov/42072359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,38361632,Search for chromosomal instability aiding variants reveal naturally occurring kinetochore gene variants that perturb chromosome segregation.,2024,10.1016/j.isci.2024.109007,https://pubmed.ncbi.nlm.nih.gov/38361632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,38849978,SKA3/PTTG1/c-MYC signal loop drives the progression of colorectal cancer.,2024,10.1002/ctm2.1730,https://pubmed.ncbi.nlm.nih.gov/38849978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,39214909,"Therapeutic Potential of PLK1, KIF4A, CDCA5, UBE2C, CDT1, SKA3, AURKB, and PTTG1 Genes in Triple-Negative Breast Cancer: Correlating Their Expression with Sensitivity to GSK 461364 and IKK 16 Drugs.",2025,10.1007/s10528-024-10907-1,https://pubmed.ncbi.nlm.nih.gov/39214909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,37821935,Hypoxia-induced SKA3 promoted cholangiocarcinoma progression and chemoresistance by enhancing fatty acid synthesis via the regulation of PAR-dependent HIF-1a deubiquitylation.,2023,10.1186/s13046-023-02842-7,https://pubmed.ncbi.nlm.nih.gov/37821935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,38643755,TFAP2A Upregulates SKA3 to Promote Glycolysis and Reduce the Sensitivity of Lung Adenocarcinoma Cells to Cisplatin.,2024,10.1159/000536557,https://pubmed.ncbi.nlm.nih.gov/38643755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,38146901,Prognostic and immunological values of SKA3 for overall survival in lung adenocarcinoma and its RNA binding protein involved mechanisms.,2024,10.1080/1120009x.2023.2298153,https://pubmed.ncbi.nlm.nih.gov/38146901/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,35535142,Integrative Multi-Omics Analysis of Identified SKA3 as a Candidate Oncogene Correlates with Poor Prognosis and Immune Infiltration in Lung Adenocarcinoma.,2022,10.2147/ijgm.s359987,https://pubmed.ncbi.nlm.nih.gov/35535142/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,37924072,Establishment and application of an iELISA detection method for measuring apical membrane antigen 1 (AMA1) antibodies of Toxoplasma gondii in cats.,2023,10.1186/s12917-023-03775-1,https://pubmed.ncbi.nlm.nih.gov/37924072/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,37701707,High spindle and kinetochore-associated complex subunit-3 expression predicts poor prognosis and correlates with adverse immune infiltration in hepatocellular carcinoma.,2023,10.4240/wjgs.v15.i8.1600,https://pubmed.ncbi.nlm.nih.gov/37701707/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,35546682,SKA3 is a prognostic biomarker and associated with immune infiltration in bladder cancer.,2022,10.1186/s41065-022-00234-z,https://pubmed.ncbi.nlm.nih.gov/35546682/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,34737118,SKA3 overexpression predicts poor outcomes in skin cutaneous melanoma patients.,2022,10.1016/j.tranon.2021.101253,https://pubmed.ncbi.nlm.nih.gov/34737118/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,34544967,Circ-SKA3 Enhances Doxorubicin Toxicity in AC16 Cells Through miR-1303/TLR4 Axis.,2021,10.1536/ihj.20-809,https://pubmed.ncbi.nlm.nih.gov/34544967/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,34993016,Overexpression of SKA3 correlates with poor prognosis in female early breast cancer.,2021,10.7717/peerj.12506,https://pubmed.ncbi.nlm.nih.gov/34993016/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,34849004,SKA3 Serves as a Biomarker for Poor Prognosis in Kidney Renal Papillary Cell Carcinoma.,2021,10.2147/ijgm.s336799,https://pubmed.ncbi.nlm.nih.gov/34849004/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,34572901,Integrative Transcriptome Profiling Reveals SKA3 as a Novel Prognostic Marker in Non-Muscle Invasive Bladder Cancer.,2021,10.3390/cancers13184673,https://pubmed.ncbi.nlm.nih.gov/34572901/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,33224872,Identification of Spindle and Kinetochore-Associated Family Genes as Therapeutic Targets and Prognostic Biomarkers in Pancreas Ductal Adenocarcinoma Microenvironment.,2020,10.3389/fonc.2020.553536,https://pubmed.ncbi.nlm.nih.gov/33224872/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,34956967,Key Candidate Prognostic Biomarkers Correlated with Immune Infiltration in Hepatocellular Carcinoma.,2021,10.2147/jhc.s337067,https://pubmed.ncbi.nlm.nih.gov/34956967/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,34045512,Transcript levels of spindle and kinetochore-associated complex 1/3 as prognostic biomarkers correlated with immune infiltrates in hepatocellular carcinoma.,2021,10.1038/s41598-021-89628-z,https://pubmed.ncbi.nlm.nih.gov/34045512/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,30459531,SKA3 promotes cell proliferation and migration in cervical cancer by activating the PI3K/Akt signaling pathway.,2018,10.1186/s12935-018-0670-4,https://pubmed.ncbi.nlm.nih.gov/30459531/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKA3,ENSG00000165480,Unsafe,36686379,Specific Blood RNA Profiles in Individuals with Acute Spinal Cord Injury as Compared with Trauma Controls.,2023,10.1155/2023/1485135,https://pubmed.ncbi.nlm.nih.gov/36686379/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,42103860,Ubiquitination-driven fibroblast dysfunction: a multi-omics blueprint for precision diagnosis and therapy in diabetic foot ulcer.,2026,10.1038/s41598-026-45436-x,https://pubmed.ncbi.nlm.nih.gov/42103860/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,41828672,Mechanotransduction-Induced Gene Expression Reveals Activation of TGFβ/SKIL/TAZ Axis and Supports Invasive Phenotype in Triple-Negative Breast Cancer.,2026,10.3390/ijms27052456,https://pubmed.ncbi.nlm.nih.gov/41828672/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,42263550,The inflammatory-antigen presenting macrophage polarization defect contributes to sepsis-induced cardiomyopathy by downregulating the TGF-β pathway.,2026,10.1016/j.compbiolchem.2026.109142,https://pubmed.ncbi.nlm.nih.gov/42263550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,40391200,&lt;i&gt;SKIL&lt;/i&gt; Promotes Pancreatic Cancer Metastasis by Inhibiting &lt;i&gt;TSPYL2&lt;/i&gt; to Activate the TGF-β Pathway.,2025,10.1002/cai2.70011,https://pubmed.ncbi.nlm.nih.gov/40391200/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,41593724,Targeting super-enhancer-driven SKIL transcription by CDK7 inhibitor THZ1 to suppress gastric cancer progression.,2026,10.1186/s12967-026-07721-1,https://pubmed.ncbi.nlm.nih.gov/41593724/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,40869118,Multi-Layered Analysis of TGF-β Signaling and Regulation via DNA Methylation and microRNAs in Astrocytic Tumors.,2025,10.3390/ijms26167798,https://pubmed.ncbi.nlm.nih.gov/40869118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,40866997,Extracellular lactate improves neurogenesis by modulating H3K9 lactylation and SnoN expression under hypoxic conditions.,2025,10.1186/s13287-025-04571-4,https://pubmed.ncbi.nlm.nih.gov/40866997/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,41353443,Epidemiological and transcriptome data identify potential key genes involved in inflammatory response for diabetic nephropathy.,2025,10.1038/s41598-025-27023-8,https://pubmed.ncbi.nlm.nih.gov/41353443/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,40717965,Aloin protects against UVB-induced apoptosis by modulating integrated signaling pathways.,2025,10.3389/fphar.2025.1584233,https://pubmed.ncbi.nlm.nih.gov/40717965/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,38468490,NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA stabilization.,2024,10.1002/ctm2.1621,https://pubmed.ncbi.nlm.nih.gov/38468490/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,37389959,SKIL/SnoN attenuates TGF-β1/SMAD signaling-dependent collagen synthesis in hepatic fibrosis.,2023,10.17305/bb.2023.9000,https://pubmed.ncbi.nlm.nih.gov/37389959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,40877986,Donor-dependent regulation of type II and X collagen deposition by early modulation of miR-335-5p and miR-1246 during chondrogenic commitment.,2025,10.1186/s13287-025-04589-8,https://pubmed.ncbi.nlm.nih.gov/40877986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,40894357,"Comparative Copy Number Variation Profiling of GL01, an Immortalized Non-small Cell Lung Cancer Cell Line Derived from a Filipino Patient, and A549 Lung Adenocarcinoma Cells.",2025,10.47895/amp.vi0.10777,https://pubmed.ncbi.nlm.nih.gov/40894357/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,33268765,SKIL facilitates tumorigenesis and immune escape of NSCLC via upregulating TAZ/autophagy axis.,2020,10.1038/s41419-020-03200-7,https://pubmed.ncbi.nlm.nih.gov/33268765/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,38883842,Organic phosphate but not inorganic phosphate regulates Fgf23 expression through MAPK and TGF-ꞵ signaling.,2024,10.1016/j.isci.2024.109625,https://pubmed.ncbi.nlm.nih.gov/38883842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,34479589,Circ_0029803 serves as the sponge of miR-216b-5p to promote the progression of colorectal cancer by regulating SKIL expression.,2021,10.1186/s12957-021-02368-2,https://pubmed.ncbi.nlm.nih.gov/34479589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,40256241,The diagnostic and prognostic value of &lt;i&gt;C1orf174&lt;/i&gt; in colorectal cancer.,2025,10.34172/bi.30566,https://pubmed.ncbi.nlm.nih.gov/40256241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,36585417,Identification of ferroptosis-related genes and pathways in diabetic kidney disease using bioinformatics analysis.,2022,10.1038/s41598-022-26495-2,https://pubmed.ncbi.nlm.nih.gov/36585417/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,35136033,ATAD3B and SKIL polymorphisms associated with antipsychotic-induced QTc interval change in patients with schizophrenia: a genome-wide association study.,2022,10.1038/s41398-022-01825-0,https://pubmed.ncbi.nlm.nih.gov/35136033/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,36553500,Bioinformatics Prediction and Machine Learning on Gene Expression Data Identifies Novel Gene Candidates in Gastric Cancer.,2022,10.3390/genes13122233,https://pubmed.ncbi.nlm.nih.gov/36553500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,26405571,Intranodal vaccination with mRNA-optimized dendritic cells in metastatic melanoma patients.,2015,10.1080/2162402x.2015.1019197,https://pubmed.ncbi.nlm.nih.gov/26405571/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,34686774,Transcriptome and unique cytokine microenvironment of Castleman disease.,2022,10.1038/s41379-021-00950-3,https://pubmed.ncbi.nlm.nih.gov/34686774/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,35752645,Long-term hematopoietic stem cells as a parasite niche during treatment failure in visceral leishmaniasis.,2022,10.1038/s42003-022-03591-7,https://pubmed.ncbi.nlm.nih.gov/35752645/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,28230858,NGS-based transcriptome profiling reveals biomarkers for companion diagnostics of the TGF-β receptor blocker galunisertib in HCC.,2017,10.1038/cddis.2017.44,https://pubmed.ncbi.nlm.nih.gov/28230858/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,34830398,Genetic Biomarkers in Chronic Myeloid Leukemia: What Have We Learned So Far?,2021,10.3390/ijms222212516,https://pubmed.ncbi.nlm.nih.gov/34830398/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,22896657,Vaccination with mRNA-electroporated dendritic cells induces robust tumor antigen-specific CD4+ and CD8+ T cells responses in stage III and IV melanoma patients.,2012,10.1158/1078-0432.ccr-11-3368,https://pubmed.ncbi.nlm.nih.gov/22896657/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,23087058,Targeting CD4(+) T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccination.,2013,10.1158/0008-5472.can-12-1127,https://pubmed.ncbi.nlm.nih.gov/23087058/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,33114016,Mapping a Circular RNA-microRNA-mRNA-Signaling Regulatory Axis That Modulates Stemness Properties of Cancer Stem Cell Populations in Colorectal Cancer Spheroid Cells.,2020,10.3390/ijms21217864,https://pubmed.ncbi.nlm.nih.gov/33114016/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,32774143,The Influence of Adalimumab and Cyclosporine A on the Expression Profile of the Genes Related to TGFβ Signaling Pathways in Keratinocyte Cells Treated with Lipopolysaccharide A.,2020,10.1155/2020/3821279,https://pubmed.ncbi.nlm.nih.gov/32774143/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,25156511,Association between SNPs in defined functional pathways and risk of early or late toxicity as well as individual radiosensitivity.,2015,10.1007/s00066-014-0741-y,https://pubmed.ncbi.nlm.nih.gov/25156511/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SKIL,ENSG00000136603,Unsafe,8233802,"SnoI, a novel alternatively spliced isoform of the ski protooncogene homolog, sno.",1993,10.1093/nar/21.19.4632,https://pubmed.ncbi.nlm.nih.gov/8233802/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLAIN2,ENSG00000109171,Unsafe,41986449,Identification of biomarkers in myocardial hypertrophy and fibrosis via integrated transcriptomic and phosphoproteomic profiling.,2026,10.1038/s41598-026-47797-9,https://pubmed.ncbi.nlm.nih.gov/41986449/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLAIN2,ENSG00000109171,Unsafe,42371968,Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort.,2026,10.1371/journal.pgen.1012170,https://pubmed.ncbi.nlm.nih.gov/42371968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLAIN2,ENSG00000109171,Unsafe,37741612,Slain2 attenuates brain injury following subarachnoid hemorrhage by controlling axonal microtubule structure in mice.,2023,10.1016/j.neulet.2023.137495,https://pubmed.ncbi.nlm.nih.gov/37741612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLAIN2,ENSG00000109171,Unsafe,37817544,Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA.,2023,10.1177/00220345231198448,https://pubmed.ncbi.nlm.nih.gov/37817544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLAIN2,ENSG00000109171,Unsafe,39245941,Joint genotype and ancestry analysis identify novel loci associated with atopic dermatitis in African American population.,2024,10.1016/j.xhgg.2024.100350,https://pubmed.ncbi.nlm.nih.gov/39245941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLAIN2,ENSG00000109171,Unsafe,32256142,Proximity mapping of the microtubule plus-end tracking protein SLAIN2 using the BioID approach.,2020,10.3906/biy-2002-12,https://pubmed.ncbi.nlm.nih.gov/32256142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLAIN2,ENSG00000109171,Unsafe,36979179,Dynamic Regulation Genes at Microtubule Plus Ends: A Novel Class of Glioma Biomarkers.,2023,10.3390/biology12030488,https://pubmed.ncbi.nlm.nih.gov/36979179/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLAIN2,ENSG00000109171,Unsafe,30797712,MALAT1 sponges miR-106b-5p to promote the invasion and metastasis of colorectal cancer via SLAIN2 enhanced microtubules mobility.,2019,10.1016/j.ebiom.2018.12.049,https://pubmed.ncbi.nlm.nih.gov/30797712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLAIN2,ENSG00000109171,Unsafe,35848598,Identification of key candidate genes for wing length-related traits by whole-genome resequencing in 772 geese.,2022,10.1080/00071668.2022.2102889,https://pubmed.ncbi.nlm.nih.gov/35848598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLAIN2,ENSG00000109171,Unsafe,27939686,Mesenchymal Cell Invasion Requires Cooperative Regulation of Persistent Microtubule Growth by SLAIN2 and CLASP1.,2016,10.1016/j.devcel.2016.11.009,https://pubmed.ncbi.nlm.nih.gov/27939686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLAIN2,ENSG00000109171,Unsafe,28600779,The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes.,2017,10.1007/s00439-017-1821-8,https://pubmed.ncbi.nlm.nih.gov/28600779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLAIN2,ENSG00000109171,Unsafe,28981191,Retinoic acid receptor-α regulates synthetic events in human platelets.,2017,10.1111/jth.13861,https://pubmed.ncbi.nlm.nih.gov/28981191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLAIN2,ENSG00000109171,Unsafe,21646404,SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase.,2011,10.1083/jcb.201012179,https://pubmed.ncbi.nlm.nih.gov/21646404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLAIN2,ENSG00000109171,Unsafe,31235723,Discovery and characterization of functional modules associated with body weight in broilers.,2019,10.1038/s41598-019-45520-5,https://pubmed.ncbi.nlm.nih.gov/31235723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLAIN2,ENSG00000109171,Unsafe,23077057,Microtubule plus-end tracking proteins SLAIN1/2 and ch-TOG promote axonal development.,2012,10.1523/jneurosci.1240-12.2012,https://pubmed.ncbi.nlm.nih.gov/23077057/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLAIN2,ENSG00000109171,Unsafe,29044157,Facilitating identification of minimal protein binding domains by cross-linking mass spectrometry.,2017,10.1038/s41598-017-13663-y,https://pubmed.ncbi.nlm.nih.gov/29044157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLAIN2,ENSG00000109171,Unsafe,16546155,"Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a novel stem cell gene.",2006,10.1016/j.ydbio.2006.01.023,https://pubmed.ncbi.nlm.nih.gov/16546155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLAIN2,ENSG00000109171,Unsafe,10819331,Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.,2000,10.1093/dnares/7.2.143,https://pubmed.ncbi.nlm.nih.gov/10819331/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,41229113,Unexpectedly high levels of normally spliced transcripts from the pathogenic SLC10A7 alleles in a recessive form of skeletal dysplasia.,2026,10.1016/j.xhgg.2025.100545,https://pubmed.ncbi.nlm.nih.gov/41229113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,42277005,Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats.,2026,10.1038/s41467-026-73694-w,https://pubmed.ncbi.nlm.nih.gov/42277005/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,41804841,Genetic architecture of plasma pTau217 and related biomarkers in Alzheimer's disease via genome-wide association studies.,2026,10.1002/alz.71275,https://pubmed.ncbi.nlm.nih.gov/41804841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,39779512,SLC10A7 regulates O-GalNAc glycosylation and Ca2+ homeostasis in the secretory pathway: insights into SLC10A7-CDG.,2025,10.1007/s00018-024-05551-2,https://pubmed.ncbi.nlm.nih.gov/39779512/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,38037133,"Identification of novel homozygous nonsense SLC10A7 variant causing short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis and surgical management of spine.",2023,10.1186/s13023-023-02975-0,https://pubmed.ncbi.nlm.nih.gov/38037133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,38429619,Evolutionary analysis of SLC10 family members and insights into function and expression regulation of lamprey NTCP.,2024,10.1007/s10695-024-01324-7,https://pubmed.ncbi.nlm.nih.gov/38429619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,34671644,Functional Analysis of Rare Genetic Variants in the Negative Regulator of Intracellular Calcium Signaling RCAS/SLC10A7.,2021,10.3389/fmolb.2021.741946,https://pubmed.ncbi.nlm.nih.gov/34671644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,32350310,The orphan solute carrier SLC10A7 is a novel negative regulator of intracellular calcium signaling.,2020,10.1038/s41598-020-64006-3,https://pubmed.ncbi.nlm.nih.gov/32350310/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,33561315,Circular RNA circHECTD1 facilitates glioma progression by regulating the miR-296-3p/SLC10A7 axis.,2021,10.1002/jcp.30277,https://pubmed.ncbi.nlm.nih.gov/33561315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,38316848,"Identification of a lipid homeostasis-related gene signature for predicting prognosis, immunity, and chemotherapeutic effect in patients with gastric cancer.",2024,10.1038/s41598-024-52647-7,https://pubmed.ncbi.nlm.nih.gov/38316848/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,31191616,A New SLC10A7 Homozygous Missense Mutation Responsible for a Milder Phenotype of Skeletal Dysplasia With Amelogenesis Imperfecta.,2019,10.3389/fgene.2019.00504,https://pubmed.ncbi.nlm.nih.gov/31191616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,30082715,SLC10A7 mutations cause a skeletal dysplasia with amelogenesis imperfecta mediated by GAG biosynthesis defects.,2018,10.1038/s41467-018-05191-8,https://pubmed.ncbi.nlm.nih.gov/30082715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,31256060,Homo- and heterodimerization is a common feature of the solute carrier family SLC10 members.,2019,10.1515/hsz-2019-0148,https://pubmed.ncbi.nlm.nih.gov/31256060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,29878199,Integrating glycomics and genomics uncovers SLC10A7 as essential factor for bone mineralization by regulating post-Golgi protein transport and glycosylation.,2018,10.1093/hmg/ddy213,https://pubmed.ncbi.nlm.nih.gov/29878199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,23506869,The solute carrier family 10 (SLC10): beyond bile acid transport.,2013,10.1016/j.mam.2012.07.004,https://pubmed.ncbi.nlm.nih.gov/23506869/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,17628207,"Molecular and phylogenetic characterization of a novel putative membrane transporter (SLC10A7), conserved in vertebrates and bacteria.",2007,10.1016/j.ejcb.2007.06.001,https://pubmed.ncbi.nlm.nih.gov/17628207/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,26273529,High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.,2014,10.1038/boneres.2014.34,https://pubmed.ncbi.nlm.nih.gov/26273529/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,15932064,"Molecular cloning and characterization of a novel human C4orf13 gene, tentatively a member of the sodium bile acid cotransporter family.",2005,10.1007/s10528-005-1509-y,https://pubmed.ncbi.nlm.nih.gov/15932064/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,29805701,Alternative splicing events implicated in carcinogenesis and prognosis of colorectal cancer.,2018,10.7150/jca.24569,https://pubmed.ncbi.nlm.nih.gov/29805701/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,26832117,The plasma membrane protein Rch1 is a negative regulator of cytosolic calcium homeostasis and positively regulated by the calcium/calcineurin signaling pathway in budding yeast.,2016,10.1016/j.ejcb.2016.01.001,https://pubmed.ncbi.nlm.nih.gov/26832117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC10A7,ENSG00000120519,Unsafe,26881866,Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.,2016,10.1021/acs.chemrestox.5b00491,https://pubmed.ncbi.nlm.nih.gov/26881866/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,42794678,ADAR1 and ADAR2 Expression in the Thoracic Aortic Wall Correlates with Aneurysm Severity and Dissection Risk: Insights into A-to-I RNA Editing Dysregulation in Marfan Syndrome-Derived vSMCs.,2026,10.3390/ijms27188250,https://pubmed.ncbi.nlm.nih.gov/42794678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,40875335,KCC3 is not required for the distal convoluted tubule response to reduced dietary potassium intake.,2025,10.1152/ajprenal.00163.2025,https://pubmed.ncbi.nlm.nih.gov/40875335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,40009635,"A ""Knob Switch"" Model for the Phosphoregulatory Mechanism of KCC3 at the Carboxy-Terminal Domain.",2025,10.1021/acs.biochem.4c00523,https://pubmed.ncbi.nlm.nih.gov/40009635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,41500801,Spectrum of dominant Charcot-Marie-Tooth disease due to &lt;i&gt;SLC12A6&lt;/i&gt; variants.,2026,10.1136/jnnp-2025-336643,https://pubmed.ncbi.nlm.nih.gov/41500801/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,42304218,Sheep erythrocyte potassium locus highlights MYADM family regulation of electroneutral potassium chloride cotransporters (KCC).,2026,10.1186/s12864-026-13029-7,https://pubmed.ncbi.nlm.nih.gov/42304218/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,35274823,Erythroid-specific inactivation of Slc12a6/Kcc3 by EpoR promoter-driven Cre expression reduces K-Cl cotransport activity in mouse erythrocytes.,2022,10.14814/phy2.15186,https://pubmed.ncbi.nlm.nih.gov/35274823/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,40883263,Unveiling causal regulatory mechanisms through cell-state parallax.,2025,10.1038/s41467-025-61337-5,https://pubmed.ncbi.nlm.nih.gov/40883263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,38927257,Peripheral Blood Mononuclear Cell Expression of Cation-Chloride Cotransporter (CCC) Genes in Premenstrual Dysphoric Disorder (PMDD) across the Menstrual Cycle-A Preliminary Study.,2024,10.3390/biology13060377,https://pubmed.ncbi.nlm.nih.gov/38927257/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,37530088,The K-Cl cotransporter-3 in the mammalian kidney.,2023,10.1097/mnh.0000000000000911,https://pubmed.ncbi.nlm.nih.gov/37530088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,35874803,"KCC3a, a Strong Candidate Pathway for K+ Loss in Alkalemia.",2022,10.3389/fcell.2022.931326,https://pubmed.ncbi.nlm.nih.gov/35874803/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,34706912,Expanding the phenotype of SLC12A6-associated sensorimotor neuropathy.,2021,10.1136/bcr-2021-244641,https://pubmed.ncbi.nlm.nih.gov/34706912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,36542484,"Late-onset sensory-motor axonal neuropathy, a novel SLC12A6-related phenotype.",2023,10.1093/brain/awac488,https://pubmed.ncbi.nlm.nih.gov/36542484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,31439721,De novo variants in SLC12A6 cause sporadic early-onset progressive sensorimotor neuropathy.,2020,10.1136/jmedgenet-2019-106273,https://pubmed.ncbi.nlm.nih.gov/31439721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,41456368,Expression of genetic peripheral neuropathies in South African children.,2026,10.1016/j.nmd.2025.106283,https://pubmed.ncbi.nlm.nih.gov/41456368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,35733399,Novel heterozygous variants of SLC12A6 in Japanese families with Charcot-Marie-Tooth disease.,2022,10.1002/acn3.51603,https://pubmed.ncbi.nlm.nih.gov/35733399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,37201245,"KCCs, NKCCs, and NCC: Potential targets for cardiovascular therapeutics? A comprehensive review of cell and region specific expression and function.",2023,10.1016/j.acthis.2023.152045,https://pubmed.ncbi.nlm.nih.gov/37201245/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,33323309,Whole-exome sequencing identifies a heterozygous mutation in SLC12A6 associated with hereditary sensory and motor neuropathy.,2021,10.1016/j.nmd.2020.11.002,https://pubmed.ncbi.nlm.nih.gov/33323309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,38223443,The role of SLC12A family of cation-chloride cotransporters and drug discovery methodologies.,2023,10.1016/j.jpha.2023.09.002,https://pubmed.ncbi.nlm.nih.gov/38223443/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,33513812,Targeting the WNK-SPAK/OSR1 Pathway and Cation-Chloride Cotransporters for the Therapy of Stroke.,2021,10.3390/ijms22031232,https://pubmed.ncbi.nlm.nih.gov/33513812/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,35848620,The erythroid K-Cl cotransport inhibitor [(dihydroindenyl)oxy]acetic acid blocks erythroid Ca2+-activated K+ channel KCNN4.,2022,10.1152/ajpcell.00240.2022,https://pubmed.ncbi.nlm.nih.gov/35848620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,33596149,Temporal manipulation of KCC3 expression in juvenile or adult mice suggests irreversible developmental deficit in hereditary motor sensory neuropathy with agenesis of the corpus callosum.,2021,10.1152/ajpcell.00594.2020,https://pubmed.ncbi.nlm.nih.gov/33596149/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,31393094,SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus.,2019,10.1002/mgg3.892,https://pubmed.ncbi.nlm.nih.gov/31393094/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,27485015,Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter.,2016,10.1126/scisignal.aae0546,https://pubmed.ncbi.nlm.nih.gov/27485015/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,34877495,DNA repair factor KAT5 prevents ischemic acute kidney injury through glomerular filtration regulation.,2021,10.1016/j.isci.2021.103436,https://pubmed.ncbi.nlm.nih.gov/34877495/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,38098790,"Valorization of the essential oil from Drypetes gossweileri S. Moore (Putranjivaceae): in vitro, in vivo, and in silico nematicidal activity.",2023,10.3389/fpls.2023.1260360,https://pubmed.ncbi.nlm.nih.gov/38098790/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,25116249,Deletion of KCC3 in parvalbumin neurons leads to locomotor deficit in a conditional mouse model of peripheral neuropathy associated with agenesis of the corpus callosum.,2014,10.1016/j.bbr.2014.08.005,https://pubmed.ncbi.nlm.nih.gov/25116249/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,22423107,Loss of neuronal potassium/chloride cotransporter 3 (KCC3) is responsible for the degenerative phenotype in a conditional mouse model of hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum.,2012,10.1523/jneurosci.3679-11.2012,https://pubmed.ncbi.nlm.nih.gov/22423107/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,31835175,Genetic disruption of KCC cotransporters in a mouse model of thalassemia intermedia.,2020,10.1016/j.bcmd.2019.102389,https://pubmed.ncbi.nlm.nih.gov/31835175/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,31352162,Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease.,2019,10.1016/j.bcmd.2019.102346,https://pubmed.ncbi.nlm.nih.gov/31352162/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,25110711,The K-Cl cotransporter KCC3 as an independent prognostic factor in human esophageal squamous cell carcinoma.,2014,10.1155/2014/936401,https://pubmed.ncbi.nlm.nih.gov/25110711/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,34512723,ACE2 Netlas: In silico Functional Characterization and Drug-Gene Interactions of ACE2 Gene Network to Understand Its Potential Involvement in COVID-19 Susceptibility.,2021,10.3389/fgene.2021.698033,https://pubmed.ncbi.nlm.nih.gov/34512723/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,33794121,Identification of the protective effect of Polygonatum sibiricum polysaccharide on d-galactose-induced brain ageing in mice by the systematic characterization of a circular RNA-associated ceRNA network.,2021,10.1080/13880209.2021.1893347,https://pubmed.ncbi.nlm.nih.gov/33794121/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,31296230,K+-Cl- cotransporter 1 (KCC1): a housekeeping membrane protein that plays key supplemental roles in hematopoietic and cancer cells.,2019,10.1186/s13045-019-0766-x,https://pubmed.ncbi.nlm.nih.gov/31296230/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,17510708,Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.,2007,10.1172/jci30630,https://pubmed.ncbi.nlm.nih.gov/17510708/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,21486764,Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival.,2011,10.1113/jphysiol.2010.203703,https://pubmed.ncbi.nlm.nih.gov/21486764/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,21628467,Transit defect of potassium-chloride Co-transporter 3 is a major pathogenic mechanism in hereditary motor and sensory neuropathy with agenesis of the corpus callosum.,2011,10.1074/jbc.m111.226894,https://pubmed.ncbi.nlm.nih.gov/21628467/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,16048901,NH2-terminal heterogeneity in the KCC3 K+-Cl- cotransporter.,2005,10.1152/ajprenal.00464.2004,https://pubmed.ncbi.nlm.nih.gov/16048901/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC12A6,ENSG00000140199,Unsafe,10600773,"Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter.",1999,10.1152/ajpcell.1999.277.6.c1210,https://pubmed.ncbi.nlm.nih.gov/10600773/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,42737719,Monocarboxylate Transporter 2 (MCT2) Reduction Is Associated with Increased Lung Tumor Growth and Alterations in the Immune Microenvironment in a Subcutaneous Tumor Model.,2026,10.3390/ijms27177819,https://pubmed.ncbi.nlm.nih.gov/42737719/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,42716231,Neuronal monocarboxylate transporter 2 is downregulated and aggravates seizures in a rat model of infantile epileptic spasms.,2026,10.1016/j.nbd.2026.107604,https://pubmed.ncbi.nlm.nih.gov/42716231/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,42315503,Monocarboxylate transporter 2 regulates maintenance of myelin and axonal integrity by oligodendrocytes.,2026,10.1038/s41467-026-74488-w,https://pubmed.ncbi.nlm.nih.gov/42315503/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,40410718,Tumor suppressing function of SLC16A7 in bladder cancer and its pan-cancer analysis.,2025,10.1186/s12885-025-14345-z,https://pubmed.ncbi.nlm.nih.gov/40410718/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,42137367,Compensatory transporter upregulation facilitates retinal ganglion cell survival in glaucoma after MCT2 elimination.,2026,10.3389/fcell.2026.1805959,https://pubmed.ncbi.nlm.nih.gov/42137367/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,42261079,Intracranial Human BT12 Glioblastoma Xenograft is [&lt;sup&gt;18&lt;/sup&gt;F]FET PET Negative but 6-[&lt;sup&gt;18&lt;/sup&gt;F]Fluoronicotinic Acid PET Positive: Exploring a Novel Approach for Clinical Glioblastoma Imaging.,2026,10.1021/acs.molpharmaceut.6c00279,https://pubmed.ncbi.nlm.nih.gov/42261079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,42624199,Hypoxic preconditioning alleviates hypoxia-induced anapyrexia by attenuating cerebral lactate elevation.,2026,10.1016/j.neuroscience.2026.08.030,https://pubmed.ncbi.nlm.nih.gov/42624199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,41767714,Analyses of astrocyte-neuron lactate shuttle transporter levels in brain tissues from people with HIV-associated neurocognitive impairment and Alzheimer's disease.,2026,10.1515/nipt-2025-0019,https://pubmed.ncbi.nlm.nih.gov/41767714/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,40178895,RPE-specific MCT2 expression promotes cone survival in models of retinitis pigmentosa.,2025,10.1073/pnas.2421978122,https://pubmed.ncbi.nlm.nih.gov/40178895/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,42693052,[Danggui Shaoyao San promotes ketone body production and utilization to improve brain energy metabolism and prevent Alzheimer's disease].,2026,10.19540/j.cnki.cjcmm.20260505.801,https://pubmed.ncbi.nlm.nih.gov/42693052/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,42799796,Systemic AR-C155858 During Fixed Treadmill Exercise in MPTP Mice: An Exploratory Study.,2026,10.1007/s11064-026-04903-7,https://pubmed.ncbi.nlm.nih.gov/42799796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,41721736,Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice.,2026,10.1111/acel.70423,https://pubmed.ncbi.nlm.nih.gov/41721736/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,41046267,Neuronal MCT2 promotes angiogenesis via lactate in the developing mouse neocortex.,2026,10.1038/s41418-025-01581-w,https://pubmed.ncbi.nlm.nih.gov/41046267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,41981183,Lactate treatment improves brain biochemistry and cognitive function in transgenic Alzheimer's and wild-type mice.,2026,10.1038/s41598-026-48154-6,https://pubmed.ncbi.nlm.nih.gov/41981183/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,40397883,Validation of a data-driven multicomponent T2 analysis for quantifying myelin content in the cuprizone mouse model of multiple sclerosis.,2025,10.1371/journal.pone.0323614,https://pubmed.ncbi.nlm.nih.gov/40397883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,41381736,Structure-guided screening identifies Tucatinib as dual inhibitor for MCT1/2.,2026,10.1038/s44319-025-00661-9,https://pubmed.ncbi.nlm.nih.gov/41381736/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,42046815,SLC16A7 and WDR38 form a mitochondrial-centric axis driving lung cancer through metabolic reprogramming and REDOX adaptation.,2026,10.1515/jtim-2025-0056,https://pubmed.ncbi.nlm.nih.gov/42046815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,40195216,GLUT1 and Cerebral Glucose Hypometabolism in Human Focal Cortical Dysplasia Is Associated with Hypermethylation of Key Glucose Regulatory Genes.,2025,10.1007/s12035-025-04871-z,https://pubmed.ncbi.nlm.nih.gov/40195216/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,42163376,Single-cell analysis reveals that NRG1/3-ERBB4 signaling affects metabolic reprogramming and immune escape in Wilms tumor.,2026,10.1186/s13062-026-00780-w,https://pubmed.ncbi.nlm.nih.gov/42163376/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,41048117,Lactate Transport via Glial MCT1 and Neuronal MCT2 Is Not Required for Synchronized Synaptic Transmission in Hippocampal Slices Supplied With Glucose.,2025,10.1111/jnc.70251,https://pubmed.ncbi.nlm.nih.gov/41048117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,42844160,Inhibition and Knockdown of Monocarboxylate Transporter 1 Induce L-Lactate Accumulation in T-Cell Acute Lymphoblastic Leukemia Cells.,2026,10.1248/bpb.b26-00267,https://pubmed.ncbi.nlm.nih.gov/42844160/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,41122432,Lactate Metabolism in Intervertebral Disc Degeneration: Unveiling Novel Mechanisms Through Bioinformatics.,2025,10.1002/jsp2.70126,https://pubmed.ncbi.nlm.nih.gov/41122432/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,41252858,Maternal effects of choline on skeletal muscle development and intramuscular fat deposition in broiler offspring.,2026,10.1016/j.psj.2025.106104,https://pubmed.ncbi.nlm.nih.gov/41252858/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,39669362,Lactylation-related gene signature accurately predicts prognosis and immunotherapy response in gastric cancer.,2024,10.3389/fonc.2024.1485580,https://pubmed.ncbi.nlm.nih.gov/39669362/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,40338456,Exercise-Induced Hippocampal Neurogenesis Is Attenuated by Inhibition of Monocarboxylate Transporter 2.,2025,10.1007/s12035-025-04986-3,https://pubmed.ncbi.nlm.nih.gov/40338456/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,42464365,Aging-driven transcriptional programs in diabetic kidney disease: multi-omics discovery of diagnostic biomarkers and drug-repurposing targets.,2026,10.1186/s13148-026-02207-9,https://pubmed.ncbi.nlm.nih.gov/42464365/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,42002805,Dynamic interplay of maternal and paternal contributions to offspring phenotype in Eurasian perch.,2026,10.1186/s12915-026-02602-x,https://pubmed.ncbi.nlm.nih.gov/42002805/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,40205883,Muscle-Derived miR-200a-3p Through Light-Intensity Exercise May Contribute to Improve Memory Dysfunction in Type 2 Diabetic Mice.,2025,10.1096/fj.202500336r,https://pubmed.ncbi.nlm.nih.gov/40205883/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,34638954,Monocarboxylate Transporter-2 Expression Restricts Tumor Growth in a Murine Model of Lung Cancer: A Multi-Omic Analysis.,2021,10.3390/ijms221910616,https://pubmed.ncbi.nlm.nih.gov/34638954/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,40617965,Lactate-related gene signatures predict prognosis and immune profiles in esophageal squamous cell carcinoma.,2025,10.1038/s41598-025-10456-6,https://pubmed.ncbi.nlm.nih.gov/40617965/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,41533036,Effect of Ang II Receptor Inhibition on GSK-3β/CREB/BDNF Signalling in REM Sleep Deprivation-Induced Memory Impairment.,2026,10.1007/s11064-025-04660-z,https://pubmed.ncbi.nlm.nih.gov/41533036/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,15505343,"Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes.",2004,10.1369/jhc.4a6306.2004,https://pubmed.ncbi.nlm.nih.gov/15505343/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC16A7,ENSG00000118596,Unsafe,9786900,Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter.,1998,10.1074/jbc.273.44.28959,https://pubmed.ncbi.nlm.nih.gov/9786900/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,42840239,Structure-based virtual screening identifies ethyl rosmarinate as a SLC1A6-targeted therapeutic candidate for bladder cancer.,2026,10.3389/fphar.2026.1895264,https://pubmed.ncbi.nlm.nih.gov/42840239/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,41946908,Ethanol disrupts cerebellar synaptic modulation by enhancing EAAT4-mediated glutamate uptake.,2026,10.1038/s42003-026-09978-0,https://pubmed.ncbi.nlm.nih.gov/41946908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,40481876,Glutamate transporter SLC1A6 promotes resistance to immunotherapy in cancer.,2025,10.1007/s00262-025-04074-4,https://pubmed.ncbi.nlm.nih.gov/40481876/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,41853687,Modulation of glutamate metabolism in Niemann-pick disease type C1 mice.,2026,10.1016/j.ymgmr.2026.101303,https://pubmed.ncbi.nlm.nih.gov/41853687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,42750204,Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage-Specific Vulnerabilities in Alzheimer's Disease.,2026,10.1002/advs.77822,https://pubmed.ncbi.nlm.nih.gov/42750204/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,40458558,Normal hearing function genetics: have you heard all about it? An integrated approach of genome-wide association studies and transcriptome-wide association studies in three Italian cohorts.,2025,10.3389/fgene.2025.1522338,https://pubmed.ncbi.nlm.nih.gov/40458558/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,40372562,Alterations in the Na&lt;sup&gt;+&lt;/sup&gt;/H&lt;sup&gt;+&lt;/sup&gt; Exchanger NHE6 and Glutamate Transporters may Influence Purkinje Cell Fate in ARSACS.,2025,10.1007/s12311-025-01850-x,https://pubmed.ncbi.nlm.nih.gov/40372562/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,41044096,Ceftriaxone suppresses the severity of paclitaxel-induced glutamate-mediated chronic pain in experimental animals.,2025,10.1038/s41598-025-08119-7,https://pubmed.ncbi.nlm.nih.gov/41044096/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,42436233,Associations between the intratumoral microbiome and the host transcriptome in bladder cancer and their implications for prognostic prediction.,2026,10.1038/s41598-026-61819-6,https://pubmed.ncbi.nlm.nih.gov/42436233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,42792930,Integrated Multi-Omics Analysis Reveals Lipid Metabolism as a Key Contributor to the Growth-Meat Quality Trade-Off Among Genetically Divergent Chicken Breeds.,2026,10.3390/genes17091036,https://pubmed.ncbi.nlm.nih.gov/42792930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,39519239,Amino Acid Compound 2 (AAC2) Treatment Counteracts Insulin-Induced Synaptic Gene Expression and Seizure-Related Mortality in a Mouse Model of Alzheimer's Disease.,2024,10.3390/ijms252111689,https://pubmed.ncbi.nlm.nih.gov/39519239/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,39964323,Immunohistochemistry and Spatial Density of Müller Cells in the Human Fovea.,2025,10.1167/iovs.66.2.46,https://pubmed.ncbi.nlm.nih.gov/39964323/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,37538371,Apo state pore opening as functional basis of increased EAAT anion channel activity in episodic ataxia 6.,2023,10.3389/fphys.2023.1147216,https://pubmed.ncbi.nlm.nih.gov/37538371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,40299102,Excitatory Amino Acid Transporters as Therapeutic Targets in the Treatment of Neurological Disorders: Their Roles and Therapeutic Prospects.,2025,10.1007/s11064-025-04400-3,https://pubmed.ncbi.nlm.nih.gov/40299102/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,36789738,"4-F-PCP, a Novel PCP Analog Ameliorates the Depressive-Like Behavior of Chronic Social Defeat Stress Mice via NMDA Receptor Antagonism.",2023,10.4062/biomolther.2022.159,https://pubmed.ncbi.nlm.nih.gov/36789738/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,33927617,Radioresistant Nasopharyngeal Carcinoma Cells Exhibited Decreased Cisplatin Sensitivity by Inducing SLC1A6 Expression.,2021,10.3389/fphar.2021.629264,https://pubmed.ncbi.nlm.nih.gov/33927617/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,34400517,Climbing Fiber-Mediated Spillover Transmission to Interneurons Is Regulated by EAAT4.,2021,10.1523/jneurosci.0616-21.2021,https://pubmed.ncbi.nlm.nih.gov/34400517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,34502151,The Amino Acid-mTORC1 Pathway Mediates APEC TW-XM-Induced Inflammation in bEnd.3 Cells.,2021,10.3390/ijms22179245,https://pubmed.ncbi.nlm.nih.gov/34502151/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,37543576,Construction and validation of an immune infiltration-related risk model for predicting prognosis and immunotherapy response in low grade glioma.,2023,10.1186/s12885-023-11222-5,https://pubmed.ncbi.nlm.nih.gov/37543576/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,37849808,Multivariate piecewise linear regression model to predict radiosensitivity using the association with the genome-wide copy number variation.,2023,10.3389/fonc.2023.1154222,https://pubmed.ncbi.nlm.nih.gov/37849808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,36523302,Multiomics analysis of ferroptosis-related molecular subtypes in muscle-invasive bladder cancer immunotherapy.,2022,10.21037/tcr-22-1653,https://pubmed.ncbi.nlm.nih.gov/36523302/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,34905506,A novel 6-gene signature derived from tumor-infiltrating T cells and neutrophils predicts survival of bladder urothelial carcinoma.,2021,10.18632/aging.203770,https://pubmed.ncbi.nlm.nih.gov/34905506/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,32590943,Neuroprotective effects of magnesium L-threonate in a hypoxic zebrafish model.,2020,10.1186/s12868-020-00580-6,https://pubmed.ncbi.nlm.nih.gov/32590943/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,34920184,N6-methyladenosine-mediated downregulation of miR-374c-5p promotes cadmium-induced cell proliferation and metastasis by targeting GRM3 in breast cancer cells.,2022,10.1016/j.ecoenv.2021.113085,https://pubmed.ncbi.nlm.nih.gov/34920184/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,28173092,Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of β-III spectrin and GLAST.,2016,10.1093/hmg/ddw274,https://pubmed.ncbi.nlm.nih.gov/28173092/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,31047920,Glutamate transport system as a key constituent of glutamosome: Molecular pathology and pharmacological modulation in chronic pain.,2019,10.1016/j.neuropharm.2019.04.029,https://pubmed.ncbi.nlm.nih.gov/31047920/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,30456316,"Effects of repetitive transcranial magnetic stimulation on ER stress-related genes and glutamate, γ-aminobutyric acid and glycine transporter genes in mouse brain.",2019,10.1016/j.bbrep.2018.10.015,https://pubmed.ncbi.nlm.nih.gov/30456316/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,30670950,Electrophysiological Excitability and Parallel Fiber Synaptic Properties of Zebrin-Positive and -Negative Purkinje Cells in Lobule VIII of the Mouse Cerebellar Slice.,2018,10.3389/fncel.2018.00513,https://pubmed.ncbi.nlm.nih.gov/30670950/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,20599790,Why we should be vigilant: drug cytotoxicity observed with in vitro transporter inhibition studies.,2010,10.1016/j.bcp.2010.06.012,https://pubmed.ncbi.nlm.nih.gov/20599790/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,20505095,Zones of enhanced glutamate release from climbing fibers in the mammalian cerebellum.,2010,10.1523/jneurosci.5118-09.2010,https://pubmed.ncbi.nlm.nih.gov/20505095/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,17182680,Spatiotemporal analysis of purkinje cell degeneration relative to parasagittal expression domains in a model of neonatal viral infection.,2007,10.1128/jvi.02245-06,https://pubmed.ncbi.nlm.nih.gov/17182680/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC1A6,ENSG00000105143,Unsafe,7791878,An excitatory amino-acid transporter with properties of a ligand-gated chloride channel.,1995,10.1038/375599a0,https://pubmed.ncbi.nlm.nih.gov/7791878/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,41814388,A prognostic model for gastric cancer based on histamine-associated prognostic genes.,2026,10.1186/s41065-026-00659-w,https://pubmed.ncbi.nlm.nih.gov/41814388/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,41733804,Histone lactatation-related genes GPR19 and SLC22A16 are important diagnostic markers and drug treatment targets for prostate cancer.,2026,10.1007/s13258-026-01740-4,https://pubmed.ncbi.nlm.nih.gov/41733804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,41333034,Multi-Omics Mendelian Randomization Identifies Therapeutic Targets for Sjögren's Disease with Clinical and Bayesian Validation.,2025,10.2147/jir.s543644,https://pubmed.ncbi.nlm.nih.gov/41333034/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,39670016,"Altered carnitine transporter genes (SLC22A5, SLC22A16, SLC6A14) expression pattern among lung cancer patients.",2024,10.21037/tlcr-24-448,https://pubmed.ncbi.nlm.nih.gov/39670016/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,40572022,Mouse genome engineering uncovers 18 genes dispensable for male reproduction.,2026,10.1111/andr.70088,https://pubmed.ncbi.nlm.nih.gov/40572022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,38927694,Long Noncoding RNA 6302 Regulates Chicken Preadipocyte Differentiation by Targeting SLC22A16.,2024,10.3390/genes15060758,https://pubmed.ncbi.nlm.nih.gov/38927694/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,41134052,Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion.,2026,10.1002/advs.202511569,https://pubmed.ncbi.nlm.nih.gov/41134052/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,38710730,The transcription factor OCT6 promotes the dissolution of the naïve pluripotent state by repressing Nanog and activating a formative state gene regulatory network.,2024,10.1038/s41598-024-59247-5,https://pubmed.ncbi.nlm.nih.gov/38710730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,41761334,Sublytic pyroptosis blocks Schwann cell remyelination through caspase-1-mediated Tyro3 cleavage.,2026,10.1186/s12974-026-03724-3,https://pubmed.ncbi.nlm.nih.gov/41761334/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,40462177,PSMB10 maintains the stemness of chemotherapeutic drug-resistant leukemia cells by inhibiting senescence and cytotoxic T lymphocyte-mediated killing in a ubiquitinated degradation manner.,2025,10.1186/s13046-025-03420-9,https://pubmed.ncbi.nlm.nih.gov/40462177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,40508044,Identification of Genomic Structural Variations in Xinjiang Brown Cattle by Deep Sequencing and Their Association with Body Conformation Traits.,2025,10.3390/ijms26115234,https://pubmed.ncbi.nlm.nih.gov/40508044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,40283974,Pharmacogenetics as a Future Tool to Risk-Stratify Breast Cancer Patients According to Chemotoxicity Potential from the Doxorubicin Hydrochloride and Cyclophosphamide (AC) Regimen.,2025,10.3390/ph18040539,https://pubmed.ncbi.nlm.nih.gov/40283974/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,36052561,OCT6 inhibits differentiation of porcine-induced pluripotent stem cells through MAPK and PI3K signaling regulation.,2022,10.24272/j.issn.2095-8137.2022.220,https://pubmed.ncbi.nlm.nih.gov/36052561/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,39823724,Phosphodiesterase 4D inhibition improves the functional and molecular outcome in a mouse and human model of Charcot Marie Tooth disease 1 A.,2025,10.1016/j.biopha.2025.117828,https://pubmed.ncbi.nlm.nih.gov/39823724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,40605857,Causal association analysis between blood metabolomes and osteopenia and therapeutic target prediction for mechanomedicine.,2025,10.1016/j.mbm.2025.100137,https://pubmed.ncbi.nlm.nih.gov/40605857/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,38582508,Phosphorylation of IDH1 Facilitates Progestin Resistance in Endometrial Cancer.,2024,10.1002/advs.202310208,https://pubmed.ncbi.nlm.nih.gov/38582508/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,38444021,The POU-HD TFs impede the replication efficiency of several human papillomavirus genomes.,2024,10.1186/s12985-024-02334-w,https://pubmed.ncbi.nlm.nih.gov/38444021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,40452391,"Transcription Factors and Coregulators in Schwann Cell Differentiation, Myelination, and Remyelination: Implications for Peripheral Neuropathy.",2025,10.1002/jnr.70053,https://pubmed.ncbi.nlm.nih.gov/40452391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,38513237,Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis in vivo and in vitro.,2024,10.1182/blood.2024023983,https://pubmed.ncbi.nlm.nih.gov/38513237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,33072764,Carnitine Traffic in Cells. Link With Cancer.,2020,10.3389/fcell.2020.583850,https://pubmed.ncbi.nlm.nih.gov/33072764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,42865824,"Myelination and Remyelination in Peripheral Nerve Injury: Mechanisms, Regulation, and Therapeutic Perspectives.",2026,10.1002/mco2.71019,https://pubmed.ncbi.nlm.nih.gov/42865824/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,38491961,Effects of pharmacogenetics on pharmacokinetics and toxicity of doxorubicin in Egyptian breast cancer patients.,2024,10.1080/00498254.2024.2330493,https://pubmed.ncbi.nlm.nih.gov/38491961/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,37248319,Model for predicting prognosis and immunotherapy based on CD&lt;sup&gt;+&lt;/sup&gt;8 T cells infiltration in neuroblastoma.,2023,10.1007/s00432-023-04897-7,https://pubmed.ncbi.nlm.nih.gov/37248319/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,33135528,Impact of combinations of single-nucleotide polymorphisms of anthracycline transporter genes upon the efficacy and toxicity of induction chemotherapy in acute myeloid leukemia.,2021,10.1080/10428194.2020.1839650,https://pubmed.ncbi.nlm.nih.gov/33135528/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,35761855,Pharmacogenetics of Breast Cancer Treatments: A Sub-Saharan Africa Perspective.,2022,10.2147/pgpm.s308531,https://pubmed.ncbi.nlm.nih.gov/35761855/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,33774021,Association between the genetic polymorphisms of the pharmacokinetics of anthracycline drug and myelosuppression in a patient with breast cancer with anthracycline-based chemotherapy.,2021,10.1016/j.lfs.2021.119392,https://pubmed.ncbi.nlm.nih.gov/33774021/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,32235849,Genetic 3'UTR variations and clinical factors significantly contribute to survival prediction and clinical response in breast cancer patients.,2020,10.1038/s41598-020-62662-z,https://pubmed.ncbi.nlm.nih.gov/32235849/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,32375563,Differential changes in the pharmacokinetics of doxorubicin in diethylnitrosamine-induced hepatocarcinoma model rats.,2020,10.1080/00498254.2020.1765049,https://pubmed.ncbi.nlm.nih.gov/32375563/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,35608746,Bacterial over-expression of functionally active human CT2 (SLC22A16) carnitine transporter.,2022,10.1007/s11033-022-07491-1,https://pubmed.ncbi.nlm.nih.gov/35608746/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,35455734,Pharmacogenetic Profiling in High-Risk Soft Tissue Sarcomas Treated with Neoadjuvant Chemotherapy.,2022,10.3390/jpm12040618,https://pubmed.ncbi.nlm.nih.gov/35455734/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,30518936,Combination of chemotherapy and physical plasma elicits melanoma cell death via upregulation of SLC22A16.,2018,10.1038/s41419-018-1221-6,https://pubmed.ncbi.nlm.nih.gov/30518936/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,31981210,"Genetic Polymorphisms Affecting Cardiac Biomarker Concentrations in Children with Cancer: an Analysis from the ""European Paediatric Oncology Off-patents Medicines Consortium"" (EPOC) Trial.",2020,10.1007/s13318-019-00592-6,https://pubmed.ncbi.nlm.nih.gov/31981210/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,34948211,SLC22 Transporters in the Fly Renal System Regulate Response to Oxidative Stress In Vivo.,2021,10.3390/ijms222413407,https://pubmed.ncbi.nlm.nih.gov/34948211/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,17581421,Expression of organic cation transporter SLC22A16 in human epithelial ovarian cancer: a possible role of the adriamycin importer.,2007,10.1097/01.pgp.0000236951.33914.1b,https://pubmed.ncbi.nlm.nih.gov/17581421/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,17197897,Expression of organic cation transporter SLC22A16 in human endometria.,2007,10.1097/01.pgp.0000225845.67245.b3,https://pubmed.ncbi.nlm.nih.gov/17197897/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,15963465,Characterization of the organic cation transporter SLC22A16: a doxorubicin importer.,2005,10.1016/j.bbrc.2005.05.174,https://pubmed.ncbi.nlm.nih.gov/15963465/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,12372408,Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters.,2002,10.1016/s0006-291x(02)02343-4,https://pubmed.ncbi.nlm.nih.gov/12372408/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,12384147,Identification of OCT6 as a novel organic cation transporter preferentially expressed in hematopoietic cells and leukemias.,2002,10.1016/s0301-472x(02)00901-3,https://pubmed.ncbi.nlm.nih.gov/12384147/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC22A16,ENSG00000004809,Unsafe,12089149,Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition.,2002,10.1074/jbc.m203883200,https://pubmed.ncbi.nlm.nih.gov/12089149/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,41721478,Age-related decline in NCKX4-mediated calcium clearance accelerates aortic remodelling and drives early vascular ageing.,2026,10.1113/jp290475,https://pubmed.ncbi.nlm.nih.gov/41721478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,42158856,Identification of characteristic hub genes in the immune-active phase of chronic hepatitis B.,2026,10.3389/fimmu.2026.1769749,https://pubmed.ncbi.nlm.nih.gov/42158856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,41713129,NCKX4 regulates hippocampal Ca&lt;sup&gt;2+&lt;/sup&gt; homeostasis and contributes to contextual memory and anxiety-related behaviours.,2026,10.1016/j.ceca.2026.103126,https://pubmed.ncbi.nlm.nih.gov/41713129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,39923981,"Cellular and subcellular distribution of the K&lt;sup&gt;+&lt;/sup&gt;-dependent Na&lt;sup&gt;+&lt;/sup&gt;/Ca&lt;sup&gt;2+&lt;/sup&gt;-exchanger subtype 4, NCKX4, in mouse brain.",2025,10.1016/j.neuroscience.2025.02.013,https://pubmed.ncbi.nlm.nih.gov/39923981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,40848375,"Regulation of K&lt;sup&gt;+&lt;/sup&gt;-dependent Na&lt;sup&gt;+&lt;/sup&gt;/Ca&lt;sup&gt;2+&lt;/sup&gt;-exchanger subtype 4, NCKX4, by palmitoylation.",2025,10.1016/j.ceca.2025.103069,https://pubmed.ncbi.nlm.nih.gov/40848375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,41935024,Age-related decline in NCKX4-mediated calcium clearance accelerates aortic remodelling and drives early vascular ageing.,2026,10.1113/jp291246,https://pubmed.ncbi.nlm.nih.gov/41935024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,41540678,Cd exposure-triggered toxicity in parasitic offspring of Chouioia cunea through SLC24A3/SLC24A4-apoptosis/oxidative damage signaling pathway.,2026,10.1111/1744-7917.70226,https://pubmed.ncbi.nlm.nih.gov/41540678/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,42404704,Enamel matrix acidification caused by loss of amelogenin phosphorylation disrupts ameloblast pH-regulatory machinery.,2026,10.1093/jbmrpl/ziag096,https://pubmed.ncbi.nlm.nih.gov/42404704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,41872255,A comparative GWAS of eye colour in light and dark eye genetic backgrounds defined by HERC2 rs12913832 polymorphism in a Canadian cohort of European ancestry.,2026,10.1038/s41598-026-44580-8,https://pubmed.ncbi.nlm.nih.gov/41872255/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,42137421,PathoAnalyzer-I: An Integrative Bioinformatics Platform for Chronic Disease Analysis.,2026,10.1177/11779322261433663,https://pubmed.ncbi.nlm.nih.gov/42137421/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,39693635,Palmitoylation and regulation of potassium-dependent sodium/calcium exchangers (NCKX).,2025,10.1042/bsr20241051,https://pubmed.ncbi.nlm.nih.gov/39693635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,40342964,Key gene screening and diagnostic model establishment for acute type a aortic dissection.,2025,10.3389/fgene.2025.1586880,https://pubmed.ncbi.nlm.nih.gov/40342964/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,39259488,Transcriptome-based screening and validation of key genes for wool color in cashmere goats.,2024,10.1007/s13258-024-01562-2,https://pubmed.ncbi.nlm.nih.gov/39259488/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,36814474,Sodium/(calcium + potassium) exchanger NCKX4 optimizes KLK4 activity in the enamel matrix microenvironment to regulate ECM modeling.,2023,10.3389/fphys.2023.1116091,https://pubmed.ncbi.nlm.nih.gov/36814474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,33199372,"Calmodulin binds and modulates K+-dependent Na+/Ca2+-exchanger isoform 4, NCKX4.",2021,10.1074/jbc.ra120.015037,https://pubmed.ncbi.nlm.nih.gov/33199372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,39006025,Identification and validation of calcium extrusion-related genes prognostic signature in colon adenocarcinoma.,2024,10.7717/peerj.17582,https://pubmed.ncbi.nlm.nih.gov/39006025/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,41577183,Transcriptomics reveals new therapeutic targets for ovarian cancer.,2026,10.1016/j.slast.2026.100393,https://pubmed.ncbi.nlm.nih.gov/41577183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,40352269,Development of an immune-related gene signature applying Ridge method for improving immunotherapy responses and clinical outcomes in lung adenocarcinoma.,2025,10.7717/peerj.19121,https://pubmed.ncbi.nlm.nih.gov/40352269/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,39955314,Prelimbic cortex is involved in the regulation of morphine-induced conditioned place preference in both resistant and sensitive mice.,2025,10.1038/s41598-025-87084-7,https://pubmed.ncbi.nlm.nih.gov/39955314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,37947795,Na+/Ca2+ exchange in enamel cells is dominated by the K+-dependent NCKX exchanger.,2024,10.1085/jgp.202313372,https://pubmed.ncbi.nlm.nih.gov/37947795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,41663928,Genome-wide association analysis to identify candidate genes for growth rate traits in Chinese endemic geese.,2026,10.1186/s12864-026-12518-z,https://pubmed.ncbi.nlm.nih.gov/41663928/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,37948380,Stemness genes and miR-1247-3p expression associate with clinicopathological parameters and prognosis in lung adenocarcinoma.,2023,10.1371/journal.pone.0294171,https://pubmed.ncbi.nlm.nih.gov/37948380/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,37814076,Plasma cell signatures predict prognosis and treatment efficacy for lung adenocarcinoma.,2024,10.1007/s13402-023-00883-w,https://pubmed.ncbi.nlm.nih.gov/37814076/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,38511601,Key variants via the Alzheimer's Disease Sequencing Project whole genome sequence data.,2024,10.1002/alz.13705,https://pubmed.ncbi.nlm.nih.gov/38511601/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,33939692,Odor sampling strategies in mice with genetically altered olfactory responses.,2021,10.1371/journal.pone.0249798,https://pubmed.ncbi.nlm.nih.gov/33939692/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,33552145,A Novel Prognostic Model of Early-Stage Lung Adenocarcinoma Integrating Methylation and Immune Biomarkers.,2020,10.3389/fgene.2020.634634,https://pubmed.ncbi.nlm.nih.gov/33552145/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,33419465,"Associations of Alzheimer's disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration.",2021,10.1186/s13195-020-00755-7,https://pubmed.ncbi.nlm.nih.gov/33419465/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,22057188,The Na(+)/Ca(2+) exchanger NCKX4 governs termination and adaptation of the mammalian olfactory response.,2011,10.1038/nn.2943,https://pubmed.ncbi.nlm.nih.gov/22057188/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,28650316,"The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision.",2017,10.7554/elife.24550,https://pubmed.ncbi.nlm.nih.gov/28650316/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,34719765,Genome-wide association study and functional validation implicates JADE1 in tauopathy.,2022,10.1007/s00401-021-02379-z,https://pubmed.ncbi.nlm.nih.gov/34719765/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,28054028,The effect of the top 20 Alzheimer disease risk genes on gray-matter density and FDG PET brain metabolism.,2016,10.1016/j.dadm.2016.12.003,https://pubmed.ncbi.nlm.nih.gov/28054028/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,31784581,Prenatal electroporation-mediated gene transfer restores Slc26a4 knock-out mouse hearing and vestibular function.,2019,10.1038/s41598-019-54262-3,https://pubmed.ncbi.nlm.nih.gov/31784581/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,27066552,Late-onset Alzheimer disease risk variants mark brain regulatory loci.,2015,10.1212/nxg.0000000000000012,https://pubmed.ncbi.nlm.nih.gov/27066552/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC24A4,ENSG00000140090,Unsafe,12379639,"Molecular cloning of a fourth member of the potassium-dependent sodium-calcium exchanger gene family, NCKX4.",2002,10.1074/jbc.m210011200,https://pubmed.ncbi.nlm.nih.gov/12379639/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,41469700,SLC25A mitochondrial carriers as biomarkers and therapeutic targets of spaceflight-induced dysfunction: the ADP/ATP carrier (AAC3) as a structural case study.,2025,10.1186/s12967-025-07505-z,https://pubmed.ncbi.nlm.nih.gov/41469700/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,38808891,The essential role of adenine nucleotide translocase 4 on male reproductive function in mice.,2024,10.1590/1414-431x2024e13590,https://pubmed.ncbi.nlm.nih.gov/38808891/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,41346988,Coexistence of ulcerative colitis and neurofibromatosis type 1: a case report and literature review.,2025,10.3389/fmed.2025.1723026,https://pubmed.ncbi.nlm.nih.gov/41346988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,40898687,CFAP300 loss-of-function variant causes primary ciliary dyskinesia and male infertility via disrupting sperm flagellar assembly and acrosome formation.,2025,10.4103/aja202556,https://pubmed.ncbi.nlm.nih.gov/40898687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,42387612,Plasma proteome differences between giant cell arteritis and polymyalgia rheumatica: a pilot study.,2026,10.1186/s13075-026-03852-4,https://pubmed.ncbi.nlm.nih.gov/42387612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,38200648,Renal Mitochondrial ATP Transporter Ablation Ameliorates Obesity-Induced CKD.,2024,10.1681/asn.0000000000000294,https://pubmed.ncbi.nlm.nih.gov/38200648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,36911556,Does Electrical Status Epilepticus in Sleep Adversely Affect Language in Self-Limiting Focal Epilepsies of Childhood?,2023,10.29399/npa.28086,https://pubmed.ncbi.nlm.nih.gov/36911556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,31489369,Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD.,2019,10.1126/sciadv.aaw4597,https://pubmed.ncbi.nlm.nih.gov/31489369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,25031318,Adenine nucleotide translocase 4 is expressed within embryonic ovaries and dispensable during oogenesis.,2015,10.1177/1933719114542026,https://pubmed.ncbi.nlm.nih.gov/25031318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,25613378,Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.,2015,10.1038/cdd.2014.230,https://pubmed.ncbi.nlm.nih.gov/25613378/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,19556438,Adenine nucleotide translocase 4 deficiency leads to early meiotic arrest of murine male germ cells.,2009,10.1530/rep-09-0201,https://pubmed.ncbi.nlm.nih.gov/19556438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,33493810,Implicit cognitive flexibility in self-limited focal epilepsy of childhood: An HD-EEG study.,2021,10.1016/j.yebeh.2020.107747,https://pubmed.ncbi.nlm.nih.gov/33493810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,31805505,Impact of epilepsy on language and discourse: Two self-limited focal epileptic syndromes of childhood.,2020,10.1016/j.yebeh.2019.106671,https://pubmed.ncbi.nlm.nih.gov/31805505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,17137571,"Compartmentalization of a unique ADP/ATP carrier protein SFEC (Sperm Flagellar Energy Carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece.",2007,10.1016/j.ydbio.2006.10.004,https://pubmed.ncbi.nlm.nih.gov/17137571/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,21858006,Evolutionary genomics implies a specific function of Ant4 in mammalian and anole lizard male germ cells.,2011,10.1371/journal.pone.0023122,https://pubmed.ncbi.nlm.nih.gov/21858006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,30914420,Extramitochondrial cardiolipin suggests a novel function of mitochondria in spermatogenesis.,2019,10.1083/jcb.201808131,https://pubmed.ncbi.nlm.nih.gov/30914420/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,32600977,Exome sequencing in 57 patients with self-limited focal epilepsies of childhood with typical or atypical presentations suggests novel candidate genes.,2020,10.1016/j.ejpn.2020.05.003,https://pubmed.ncbi.nlm.nih.gov/32600977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,32613197,Identification of a potential non-coding RNA biomarker signature for amyotrophic lateral sclerosis.,2020,10.1093/braincomms/fcaa053,https://pubmed.ncbi.nlm.nih.gov/32613197/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,29352316,KANSL1 variation is not a major contributing factor in self-limited focal epilepsy syndromes of childhood.,2018,10.1371/journal.pone.0191546,https://pubmed.ncbi.nlm.nih.gov/29352316/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,33238277,Fertility Relevance Probability Analysis Shortlists Genetic Markers for Male Fertility Impairment.,2020,10.1159/000511117,https://pubmed.ncbi.nlm.nih.gov/33238277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,41747160,"Detection and quantification of microplastics in milk from Chandigarh, India: a pilot study highlighting SFEC-based spectral validation.",2026,10.1080/19440049.2026.2628941,https://pubmed.ncbi.nlm.nih.gov/41747160/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,31781568,Identification of &lt;i&gt;Trypanosoma cruzi&lt;/i&gt; Polyamine Transport Inhibitors by Computational Drug Repurposing.,2019,10.3389/fmed.2019.00256,https://pubmed.ncbi.nlm.nih.gov/31781568/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,38138083,"Characteristics, Whole-Genome Sequencing and Pathogenicity Analysis of Escherichia coli from a White Feather Broiler Farm.",2023,10.3390/microorganisms11122939,https://pubmed.ncbi.nlm.nih.gov/38138083/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,38633331,Pharmacogenomics of Hypertension in Africa: Paving the Way for a Pharmacogenetic-Based Approach for the Treatment of Hypertension in Africans.,2023,10.1155/2023/9919677,https://pubmed.ncbi.nlm.nih.gov/38633331/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,29458851,Combination of multilocus sequence typing and pulsed-field gel electrophoresis reveals an association of molecular clonality with the emergence of extensive-drug resistance (XDR) in Salmonella.,2018,10.1016/j.micres.2017.12.001,https://pubmed.ncbi.nlm.nih.gov/29458851/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,24056384,Identification of adenine nucleotide translocase 4 inhibitors by molecular docking.,2013,10.1016/j.jmgm.2013.08.016,https://pubmed.ncbi.nlm.nih.gov/24056384/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,32174961,Transcriptomic Study of Porcine Small Intestine Epithelial Cells Reveals Important Genes and Pathways Associated With Susceptibility to Escherichia coli F4ac Diarrhea.,2020,10.3389/fgene.2020.00068,https://pubmed.ncbi.nlm.nih.gov/32174961/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,32903795,Occurrence and Characterization of Salmonella Isolated From Chicken Breeder Flocks in Nine Chinese Provinces.,2020,10.3389/fvets.2020.00479,https://pubmed.ncbi.nlm.nih.gov/32903795/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,18508263,Pretreatment of woody and herbaceous biomass for enzymatic saccharification using sulfuric acid-free ethanol cooking.,2008,10.1016/j.biortech.2008.04.049,https://pubmed.ncbi.nlm.nih.gov/18508263/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,26729753,Pharmacogenomic Genome-Wide Meta-Analysis of Blood Pressure Response to β-Blockers in Hypertensive African Americans.,2016,10.1161/hypertensionaha.115.06345,https://pubmed.ncbi.nlm.nih.gov/26729753/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,19366611,Adenine nucleotide translocator 1 deficiency increases resistance of mouse brain and neurons to excitotoxic insults.,2009,10.1016/j.bbabio.2009.01.014,https://pubmed.ncbi.nlm.nih.gov/19366611/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,27641616,TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood.,2016,10.1038/srep33516,https://pubmed.ncbi.nlm.nih.gov/27641616/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,17681941,Evolutionarily conserved mammalian adenine nucleotide translocase 4 is essential for spermatogenesis.,2007,10.1074/jbc.m704386200,https://pubmed.ncbi.nlm.nih.gov/17681941/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC25A31,ENSG00000151475,Unsafe,15670820,"A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution.",2005,10.1016/j.febslet.2004.12.034,https://pubmed.ncbi.nlm.nih.gov/15670820/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,42069768,Fatty acid transporters in the porcine conceptus and early placenta and the effects of polyunsaturated fatty acids on trophoblast cells.,2026,10.1038/s41598-026-51024-w,https://pubmed.ncbi.nlm.nih.gov/42069768/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,42519381,Congenital heart defects genetic architecture in a small cohort: an integrated approach to prioritizing variants.,2026,10.3389/fcvm.2026.1850208,https://pubmed.ncbi.nlm.nih.gov/42519381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,41751270,Single-Cell Analysis Reveals Epithelial Heterogeneity and Tumor Microenvironment Characteristics During the Malignant Progression of Colorectal Cancer.,2026,10.3390/biomedicines14020371,https://pubmed.ncbi.nlm.nih.gov/41751270/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,38914245,SNPS within the SLC27A6 gene are highly associated with Hu sheep fatty acid content.,2024,10.1016/j.gene.2024.148716,https://pubmed.ncbi.nlm.nih.gov/38914245/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,41760060,Integrative transcriptomic analysis identifies synovium-derived biomarkers for OA-related synovitis and builds a validated diagnostic nomogram.,2026,10.1097/md.0000000000047559,https://pubmed.ncbi.nlm.nih.gov/41760060/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,42602500,Dietary supplementation of lysolecithin improves growth performance of piglets fed a low-nutrient density diet by modulating nutrient utilization and metabolism.,2026,10.1016/j.aninu.2026.01.011,https://pubmed.ncbi.nlm.nih.gov/42602500/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,37239243,Reduced Expression of Very-Long-Chain Acyl-CoA Synthetases SLC27A4 and SLC27A6 in the Glioblastoma Tumor Compared to the Peritumoral Area.,2023,10.3390/brainsci13050771,https://pubmed.ncbi.nlm.nih.gov/37239243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,42073311,Integrative Analysis of Volatile Flavor Compounds and Transcriptome Reveals Underlying Mechanisms Linked to Fatty Acid Content in Dabieshan Cattle.,2026,10.3390/foods15081423,https://pubmed.ncbi.nlm.nih.gov/42073311/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,39456882,Expression Profiles of Fatty Acid Transporters and the Role of n-3 and n-6 Polyunsaturated Fatty Acids in the Porcine Endometrium.,2024,10.3390/ijms252011102,https://pubmed.ncbi.nlm.nih.gov/39456882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,41274132,Placental nutrient transporter abundance in gestational diabetes mellitus with normal birthweight.,2025,10.1016/j.placenta.2025.10.015,https://pubmed.ncbi.nlm.nih.gov/41274132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,41223060,Untargeted metabolomics identifies altered cardiac metabolite and gene expression patterns in late preterm growth-restricted newborn lambs.,2025,10.1152/ajpheart.00610.2025,https://pubmed.ncbi.nlm.nih.gov/41223060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,42019356,Egfl7 regulates embryonic angiogenesis and placental vascular function in mice.,2026,10.1016/j.bbrc.2026.153770,https://pubmed.ncbi.nlm.nih.gov/42019356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,37456940,Analysis of Fatty Acid Metabolism in Fetal and Failing Hearts by Single-Cell RNA Sequencing Revealed SLC27A6 as a Critical Gene in Heart Maturation.,2023,10.6515/acs.202307_39(4).20221219b,https://pubmed.ncbi.nlm.nih.gov/37456940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,40805003,Evaluation of Alterations in Nutrient Utilization and Intestinal Health in Response to Heat Stress in Pekin Ducks Based on a Pair-Feeding Experimental Design.,2025,10.3390/ani15152213,https://pubmed.ncbi.nlm.nih.gov/40805003/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,37867472,Maturation of lipid metabolism in the fetal and newborn sheep heart.,2023,10.1152/ajpregu.00122.2023,https://pubmed.ncbi.nlm.nih.gov/37867472/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,40520872,Identification of lipid metabolism-related marker genes in colorectal cancer.,2025,10.62347/egux7327,https://pubmed.ncbi.nlm.nih.gov/40520872/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,40507856,Machine Learning-Based Analysis of Differentially Expressed Genes in the Muscle Transcriptome Between Beef Cattle and Dairy Cattle.,2025,10.3390/ijms26115046,https://pubmed.ncbi.nlm.nih.gov/40507856/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,40119254,Altered structural and transporter-related gene expression patterns in the placenta play a role in fetal demise during Porcine reproductive and respiratory syndrome virus infection.,2025,10.1186/s12864-025-11397-0,https://pubmed.ncbi.nlm.nih.gov/40119254/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,38946889,mRNA-lncRNA gene expression signature in HPV-associated neoplasia and cervical cancer.,2024,10.18699/vjgb-24-39,https://pubmed.ncbi.nlm.nih.gov/38946889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,40241125,Elucidating the role of lipid metabolism dysregulation in the transition from oral lichen planus to oral squamous cell carcinoma.,2025,10.1186/s12967-025-06431-4,https://pubmed.ncbi.nlm.nih.gov/40241125/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,35047398,Downregulation of SLC27A6 by DNA Hypermethylation Promotes Proliferation but Suppresses Metastasis of Nasopharyngeal Carcinoma Through Modulating Lipid Metabolism.,2021,10.3389/fonc.2021.780410,https://pubmed.ncbi.nlm.nih.gov/35047398/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,34100479,Abundance of solute carrier family 27 member 6 (SLC27A6) in the bovine mammary gland alters fatty acid metabolism.,2021,10.1039/d0fo03289a,https://pubmed.ncbi.nlm.nih.gov/34100479/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,33679876,"Whole-Exome Sequencing and hiPSC Cardiomyocyte Models Identify MYRIP, TRAPPC11, and SLC27A6 of Potential Importance to Left Ventricular Hypertrophy in an African Ancestry Population.",2021,10.3389/fgene.2021.588452,https://pubmed.ncbi.nlm.nih.gov/33679876/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,36967810,Methionine-Mediated Regulation of Intestinal Lipid Transportation Induced by High-Fat Diet in Rice Field Eel (Monopterus Albus).,2023,10.1155/2023/5533414,https://pubmed.ncbi.nlm.nih.gov/36967810/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,32922552,TMT-labeling Proteomics of Papillary Thyroid Carcinoma Reveal Invasive Biomarkers.,2020,10.7150/jca.47290,https://pubmed.ncbi.nlm.nih.gov/32922552/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,33989714,Effect of type 2 diabetes mellitus on placental expression and activity of nutrient transporters and their association with birth weight and neonatal adiposity.,2021,10.1016/j.mce.2021.111319,https://pubmed.ncbi.nlm.nih.gov/33989714/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,33266331,Distinctive Features of Orbital Adipose Tissue (OAT) in Graves' Orbitopathy.,2020,10.3390/ijms21239145,https://pubmed.ncbi.nlm.nih.gov/33266331/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,33312420,Inhibition of vascular adhesion protein-1 modifies hepatic steatosis in vitro and in vivo.,2020,10.4254/wjh.v12.i11.931,https://pubmed.ncbi.nlm.nih.gov/33312420/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,33343387,"Lipid-Lowering Effects of Lotus Leaf Alcoholic Extract on Serum, Hepatopancreas, and Muscle of Juvenile Grass Carp via Gene Expression.",2020,10.3389/fphys.2020.584782,https://pubmed.ncbi.nlm.nih.gov/33343387/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,30465939,Hepatic transcriptome of the euryhaline teleost Japanese seabass (Lateolabrax japonicus) fed diets characterized by α-linolenic acid or linoleic acid.,2019,10.1016/j.cbd.2018.11.005,https://pubmed.ncbi.nlm.nih.gov/30465939/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,31313401,Targeting cholecystokinin-2 receptor for pancreatic cancer chemoprevention.,2019,10.1002/mc.23084,https://pubmed.ncbi.nlm.nih.gov/31313401/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC27A6,ENSG00000113396,Unsafe,12556534,Characterization of a heart-specific fatty acid transport protein.,2003,10.1074/jbc.m211412200,https://pubmed.ncbi.nlm.nih.gov/12556534/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,41821641,A Five-Gene PANoptosis Signature Correlates with Immune Infiltration and Secondary Brain Injury in Intracerebral Hemorrhage.,2026,10.2147/ijgm.s581629,https://pubmed.ncbi.nlm.nih.gov/41821641/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,42644140,HIF1A-Associated Ferroptosis-Related Gene Signatures Reveal Candidate Circulating Biomarkers in Diabetic Nephropathy.,2026,10.1096/fba.2026-00173,https://pubmed.ncbi.nlm.nih.gov/42644140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,41632392,Potential Protective Effect of Carotid Endarterectomy: Inducing Ischemic Tolerance in Brain Tissue after Stroke.,2026,10.1007/s12031-025-02470-0,https://pubmed.ncbi.nlm.nih.gov/41632392/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,39456605,Targeting the Leloir Pathway with Galactose-Based Antimetabolites in Glioblastoma.,2024,10.3390/cancers16203510,https://pubmed.ncbi.nlm.nih.gov/39456605/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,33920278,The Leloir Cycle in Glioblastoma: Galactose Scavenging and Metabolic Remodeling.,2021,10.3390/cancers13081815,https://pubmed.ncbi.nlm.nih.gov/33920278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,38861014,In vitro effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on the expression of genes related to sperm motility and energy metabolism and intracytoplasmic sperm injection outcomes in obstructive azoospermic patients.,2024,10.1007/s11033-024-09676-2,https://pubmed.ncbi.nlm.nih.gov/38861014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,41114485,VNN2 and IL1R2 Identified as Potential Molecular Signatures in Granulosa Cells and Blood of Patients with Polycystic Ovary Syndrome (PCOS).,2026,10.2174/0118715303417042251002073727,https://pubmed.ncbi.nlm.nih.gov/41114485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,28971850,"The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease.",2017,10.3945/ajcn.116.147603,https://pubmed.ncbi.nlm.nih.gov/28971850/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,38802844,Exploring the molecular mechanisms of ferroptosis-related genes in periodontitis: a multi-dataset analysis.,2024,10.1186/s12903-024-04342-2,https://pubmed.ncbi.nlm.nih.gov/38802844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,38191519,Divergent epigenetic responses to perinatal asphyxia in severe mental disorders.,2024,10.1038/s41398-023-02709-7,https://pubmed.ncbi.nlm.nih.gov/38191519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,36518662,SLC2As as diagnostic markers and therapeutic targets in LUAD patients through bioinformatic analysis.,2022,10.3389/fphar.2022.1045179,https://pubmed.ncbi.nlm.nih.gov/36518662/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,41999681,"Dietary total antioxidant capacity alleviates inflammatory bowel disease-related surgery, gastrointestinal cancer, and mortality risks among middle-aged and older individuals.",2026,10.1016/j.jnha.2026.100848,https://pubmed.ncbi.nlm.nih.gov/41999681/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,39147981,DNA Methylation Patterns Associated with Tinnitus in Young Adults-A Pilot Study.,2024,10.1007/s10162-024-00961-2,https://pubmed.ncbi.nlm.nih.gov/39147981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,27460888,"The SLC2A14 gene: genomic locus, tissue expression, splice variants, and subcellular localization of the protein.",2016,10.1139/bcb-2015-0089,https://pubmed.ncbi.nlm.nih.gov/27460888/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,39891865,Shared genes and relevant potential molecular linkages between COVID-19 and chronic thromboembolic pulmonary hypertension (CTEPH).,2025,10.1007/s11239-025-03072-8,https://pubmed.ncbi.nlm.nih.gov/39891865/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,38299279,Disulfidptosis and its Role in Peripheral Blood Immune Cells after a Stroke: A New Frontier in Stroke Pathogenesis.,2024,10.2174/0115672026286243240105115419,https://pubmed.ncbi.nlm.nih.gov/38299279/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,36959648,SERPINE1 and its co-expressed genes are associated with the progression of clear cell renal cell carcinoma.,2023,10.1186/s12894-023-01217-6,https://pubmed.ncbi.nlm.nih.gov/36959648/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,28379195,Avian and Mammalian Facilitative Glucose Transporters.,2017,10.3390/microarrays6020007,https://pubmed.ncbi.nlm.nih.gov/28379195/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,36230616,Genome-Wide Association Study Identifies Candidate Loci Associated with Opioid Analgesic Requirements in the Treatment of Cancer Pain.,2022,10.3390/cancers14194692,https://pubmed.ncbi.nlm.nih.gov/36230616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,35920070,Transcriptional regulation of glucose transporters in human oral squamous cell carcinoma cells.,2022,10.1111/jop.13342,https://pubmed.ncbi.nlm.nih.gov/35920070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,35284940,"Circulating Immune Bioenergetic, Metabolic, and Genetic Signatures Predict Melanoma Patients' Response to Anti-PD-1 Immune Checkpoint Blockade.",2022,10.1158/1078-0432.ccr-21-3114,https://pubmed.ncbi.nlm.nih.gov/35284940/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,31996098,Keratinocytes Derived from Patient-Specific Induced Pluripotent Stem Cells Recapitulate the Genetic Signature of Psoriasis Disease.,2020,10.1089/scd.2019.0150,https://pubmed.ncbi.nlm.nih.gov/31996098/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,21295279,Functional screening of Alzheimer pathology genome-wide association signals in Drosophila.,2011,10.1016/j.ajhg.2011.01.006,https://pubmed.ncbi.nlm.nih.gov/21295279/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC2A14,ENSG00000173262,Unsafe,12504846,"GLUT14, a duplicon of GLUT3, is specifically expressed in testis as alternative splice forms.",2002,10.1006/geno.2002.7010,https://pubmed.ncbi.nlm.nih.gov/12504846/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,42738848,Developmental Changes in the Protein Expression Levels and Localization of the Vesicular Zinc Transporter (ZnT3) in the Mouse Central Auditory System.,2026,10.3390/cells15171554,https://pubmed.ncbi.nlm.nih.gov/42738848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,42707613,Focused ultrasound-mediated blood-brain barrier modulation is associated with adult hippocampal neurogenic responses linked to zinc-dependent signaling.,2026,10.7150/thno.133902,https://pubmed.ncbi.nlm.nih.gov/42707613/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,39048372,Zinc transporter ZnT3/Slc30a3 has a potential role in zinc ion influx in mouse oocytes.,2024,10.1262/jrd.2024-044,https://pubmed.ncbi.nlm.nih.gov/39048372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,41300833,&lt;i&gt;SLC30A3&lt;/i&gt; as a Zinc Transporter-Related Biomarker and Potential Therapeutic Target in Alzheimer's Disease.,2025,10.3390/genes16111380,https://pubmed.ncbi.nlm.nih.gov/41300833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,41989273,Zinc Overload in Microvessels Contributes to Blood-Brain Barrier Disruption by Activating the JAK2 Pathway After Cerebral Ischemia/Reperfusion.,2026,10.1002/cns.70885,https://pubmed.ncbi.nlm.nih.gov/41989273/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,41045626,Zinc transporter proteins in the retina as potential biomarkers for staging early Alzheimer's disease: Comparative analysis in human and mouse models.,2026,10.1016/j.neurobiolaging.2025.09.010,https://pubmed.ncbi.nlm.nih.gov/41045626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,42609005,Non-cell autonomous control of presynaptic remodeling by the hypothalamic autophagy-NPY axis.,2026,10.1080/15548627.2026.2719429,https://pubmed.ncbi.nlm.nih.gov/42609005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,40558551,Lower Zinc but Higher Calcium Content in Rodent Spinal Cord Compared to Brain.,2025,10.3390/cells14120922,https://pubmed.ncbi.nlm.nih.gov/40558551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,39383661,"Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model.",2024,10.1016/j.jtemb.2024.127540,https://pubmed.ncbi.nlm.nih.gov/39383661/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,40233591,Ginsenoside Rb1 combined with Lycium barbarum polysaccharide alleviate the Tripterygium wilfordii polyglycoside-induced oligoasthenozoospermia in mice by inhibiting ZnT3-mediated oxidative stress response.,2025,10.1016/j.jtemb.2025.127646,https://pubmed.ncbi.nlm.nih.gov/40233591/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,41504061,ZnT3-TMEM163 Mediates Zinc Homeostasis Imbalance Induced Neurodegeneration in Hippocampus.,2025,10.31083/fbl45588,https://pubmed.ncbi.nlm.nih.gov/41504061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,42730838,Effect of Zinc Status on Pubertal and Cognitive Functions in Male Offspring of Rats with Induced Zinc Deficiency During Gestation and Lactation.,2026,10.1007/s12011-026-05338-5,https://pubmed.ncbi.nlm.nih.gov/42730838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,39809542,The Astrocytic Zinc Transporter ZIP12 Is a Synaptic Protein That Contributes to Synaptic Zinc Levels in the Mouse Auditory Cortex.,2025,10.1523/jneurosci.2067-24.2025,https://pubmed.ncbi.nlm.nih.gov/39809542/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,36203844,Variants in the zinc transporter-3 encoding gene (SLC30A3) in schizophrenia and bipolar disorder: Effects on brain glutamate-A pilot study.,2022,10.3389/fpsyt.2022.929306,https://pubmed.ncbi.nlm.nih.gov/36203844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,41087886,Estrogen improves sevoflurane-induced cognitive dysfunction by regulating synaptic zinc homeostasis.,2025,10.1186/s10020-025-01364-6,https://pubmed.ncbi.nlm.nih.gov/41087886/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,39212812,Effect of the estrous cycle on zinc transporter expression in bovine cumulus-oocyte complexes and oviduct epithelial cells.,2024,10.1007/s11259-024-10523-9,https://pubmed.ncbi.nlm.nih.gov/39212812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,41760936,Mass spectrometry analysis of young and aged mice and human Alzheimer's disease with Lewy body pathology using on-slide tissue digestion.,2026,10.1007/s00216-026-06385-6,https://pubmed.ncbi.nlm.nih.gov/41760936/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,39258564,The WFS1-ZnT3-Zn&lt;sup&gt;2+&lt;/sup&gt; Axis Regulates the Vicious Cycle of Obesity and Depression.,2024,10.1002/advs.202403405,https://pubmed.ncbi.nlm.nih.gov/39258564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,38830758,Trans-synaptic Association of Vesicular Zinc Transporter 3 and Shank3 Supports Synapse-Specific Dendritic Spine Structure and Function in the Mouse Auditory Cortex.,2024,10.1523/jneurosci.0619-24.2024,https://pubmed.ncbi.nlm.nih.gov/38830758/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,39474773,Cryo-EM structures of the zinc transporters ZnT3 and ZnT4 provide insights into their transport mechanisms.,2025,10.1002/1873-3468.15047,https://pubmed.ncbi.nlm.nih.gov/39474773/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,40777132,Immunogenic cell death-related genes as prognostic biomarkers and therapeutic insights in uterine corpus endometrial carcinoma: an integrative bioinformatics analysis.,2025,10.3389/fonc.2025.1588703,https://pubmed.ncbi.nlm.nih.gov/40777132/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,39596116,Forced Overexpression and Knockout Analysis of SLC30A and SLC39A Family Genes Suggests Their Involvement in Establishing Resistance to Cisplatin in Human Cancer Cells.,2024,10.3390/ijms252212049,https://pubmed.ncbi.nlm.nih.gov/39596116/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,39312661,Cell-type-specific enhancement of deviance detection by synaptic zinc in the mouse auditory cortex.,2024,10.1073/pnas.2405615121,https://pubmed.ncbi.nlm.nih.gov/39312661/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,37962463,Neuronal Zinc Transporter ZnT3 Modulates Cerebral Ischemia-Induced Blood-Brain Barrier Disruption.,2023,10.14336/ad.2023.1011,https://pubmed.ncbi.nlm.nih.gov/37962463/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,38407877,Molecular subtype identification and prognosis stratification by a immunogenic cell death-related gene expression signature in colorectal cancer.,2024,10.1080/14737140.2024.2320187,https://pubmed.ncbi.nlm.nih.gov/38407877/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,38354264,"Cochlear zinc signaling dysregulation is associated with noise-induced hearing loss, and zinc chelation enhances cochlear recovery.",2024,10.1073/pnas.2310561121,https://pubmed.ncbi.nlm.nih.gov/38354264/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,37449644,Selective deletion of zinc transporter 3 in amacrine cells promotes retinal ganglion cell survival and optic nerve regeneration after injury.,2023,10.4103/1673-5374.373660,https://pubmed.ncbi.nlm.nih.gov/37449644/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,36980224,Environmental Enrichment Engages Vesicular Zinc Signaling to Enhance Hippocampal Neurogenesis.,2023,10.3390/cells12060883,https://pubmed.ncbi.nlm.nih.gov/36980224/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,37306234,Nanoselenium Alleviates Cadmium-Induced Cerebral Injury via Regulating Cerebral Metal Transporters and Metal-Regulatory Transcription Factor 1.,2023,10.1021/acs.jafc.3c02121,https://pubmed.ncbi.nlm.nih.gov/37306234/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,38807922,Genetic deletion of zinc transporter ZnT3 induces progressive cognitive deficits in mice by impairing dendritic spine plasticity and glucose metabolism.,2024,10.3389/fnmol.2024.1375925,https://pubmed.ncbi.nlm.nih.gov/38807922/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,35273483,Lack of Vesicular Zinc Does Not Affect the Behavioral Phenotype of Polyinosinic:Polycytidylic Acid-Induced Maternal Immune Activation Mice.,2022,10.3389/fnbeh.2022.769322,https://pubmed.ncbi.nlm.nih.gov/35273483/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,32012946,Zinc Transporter-3 Knockout Mice Demonstrate Age-Dependent Alterations in the Metalloproteome.,2020,10.3390/ijms21030839,https://pubmed.ncbi.nlm.nih.gov/32012946/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,32346941,Zinc transporter 3 modulates cell proliferation and neuronal differentiation in the adult hippocampus.,2020,10.1002/stem.3194,https://pubmed.ncbi.nlm.nih.gov/32346941/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,36382201,Nano-selenium alleviates cadmium-induced cerebellar injury by activating metal regulatory transcription factor 1 mediated metal response.,2022,10.1016/j.aninu.2022.06.021,https://pubmed.ncbi.nlm.nih.gov/36382201/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,39272182,Interactive effect of air pollution and genetic risk of depression on processing speed by resting-state functional connectivity of occipitoparietal network.,2024,10.1186/s12916-024-03614-6,https://pubmed.ncbi.nlm.nih.gov/39272182/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,34750356,Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior.,2021,10.1038/s41398-021-01693-0,https://pubmed.ncbi.nlm.nih.gov/34750356/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC30A3,ENSG00000115194,Unsafe,19521526,SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity.,2009,10.1371/journal.pone.0005896,https://pubmed.ncbi.nlm.nih.gov/19521526/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,42809390,Slc35a1-mediated endothelial sialylation controls the fate and integrity of the intestinal microvascular network in adult mice.,2026,10.1073/pnas.2601083123,https://pubmed.ncbi.nlm.nih.gov/42809390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,42241751,Strain-specific responses of avian influenza virus to disruption of solute carrier family 35 member A1 (SLC35A1) in chicken cells.,2026,10.1016/j.psj.2026.107178,https://pubmed.ncbi.nlm.nih.gov/42241751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,40613041,"A Novel Missense Variant in Ultrarare SLC35A1-CDG Alters Cellular Glycosylation, Lipid, and Energy Metabolism Without Affecting CDG Serum Markers.",2025,10.1155/humu/6290620,https://pubmed.ncbi.nlm.nih.gov/40613041/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,40541099,Genome-wide CRISPR/Cas9 screen identifies host factors for Newcastle disease virus replication.,2025,10.1016/j.psj.2025.105421,https://pubmed.ncbi.nlm.nih.gov/40541099/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,41204359,Age‑dependent and post‑intraventricular hemorrhage remodeling of the ependymal glycocalyx in mice.,2025,10.1186/s12987-025-00725-x,https://pubmed.ncbi.nlm.nih.gov/41204359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,42162024,Gene overexpression reduces inhibitory metabolites to enhance CHO cell growth and IgG1 production.,2026,10.1038/s41540-026-00707-1,https://pubmed.ncbi.nlm.nih.gov/42162024/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,39601564,Identification of SLC35A1 as an essential host factor for the transduction of multi-serotype recombinant adeno-associated virus (AAV) vectors.,2025,10.1128/mbio.03268-24,https://pubmed.ncbi.nlm.nih.gov/39601564/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,38992465,Ablation of Intestinal Epithelial Sialylation Predisposes to Acute and Chronic Intestinal Inflammation in Mice.,2024,10.1016/j.jcmgh.2024.101378,https://pubmed.ncbi.nlm.nih.gov/38992465/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,38467191,Endothelial Slc35a1 Deficiency Causes Loss of LSEC Identity and Exacerbates Neonatal Lipid Deposition in the Liver in Mice.,2024,10.1016/j.jcmgh.2024.03.002,https://pubmed.ncbi.nlm.nih.gov/38467191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,41637037,Genome-wide CRISPR/Cas9 knockout screen identifies host factors essential for bovine parainfluenza virus type 3 replication.,2026,10.1007/s11427-025-3142-x,https://pubmed.ncbi.nlm.nih.gov/41637037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,39792924,SLC35A2 gene product modulates paramyxovirus fusion events during infection.,2025,10.1371/journal.ppat.1012531,https://pubmed.ncbi.nlm.nih.gov/39792924/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,38382634,Production of CA125 with Tn antigens using a glycosylphosphatidylinositol anchoring system.,2024,10.1093/jb/mvae019,https://pubmed.ncbi.nlm.nih.gov/38382634/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,40586559,Genetic resilience or resistance in poultry against avian influenza virus: mirage or reality?,2025,10.1128/jvi.00820-25,https://pubmed.ncbi.nlm.nih.gov/40586559/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,40207931,"Cell binding, uptake, and infection of influenza A virus using recombinant antibody-based receptors.",2025,10.1128/jvi.02275-24,https://pubmed.ncbi.nlm.nih.gov/40207931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,32303557,Slc35a1 deficiency causes thrombocytopenia due to impaired megakaryocytopoiesis and excessive platelet clearance in the liver.,2021,10.3324/haematol.2019.225987,https://pubmed.ncbi.nlm.nih.gov/32303557/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,36257191,An interaction between SLC35A1 and ST3Gal4 is differentially affected by CDG-causing mutations in the SLC35A1 gene.,2022,10.1016/j.bbrc.2022.10.019,https://pubmed.ncbi.nlm.nih.gov/36257191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,34384782,A three-pocket model for substrate coordination and selectivity by the nucleotide sugar transporters SLC35A1 and SLC35A2.,2021,10.1016/j.jbc.2021.101069,https://pubmed.ncbi.nlm.nih.gov/34384782/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,36453883,Genome-Wide CRISPR/Cas9 Screen Reveals a Role for SLC35A1 in the Adsorption of Porcine Deltacoronavirus.,2022,10.1128/jvi.01626-22,https://pubmed.ncbi.nlm.nih.gov/36453883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,36982178,Inherited Thrombocytopenia Caused by Variants in Crucial Genes for Glycosylation.,2023,10.3390/ijms24065109,https://pubmed.ncbi.nlm.nih.gov/36982178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,34015330,The promiscuous binding pocket of SLC35A1 ensures redundant transport of CDP-ribitol to the Golgi.,2021,10.1016/j.jbc.2021.100789,https://pubmed.ncbi.nlm.nih.gov/34015330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,39955956,"Corrigendum to ""Genome-scale CRISPR screen identifies TRIM2 and SLC35A1 associated with porcine epidemic diarrhoea virus infection"" [Int. J. Biol. Macromol. 250 (2023) 125962].",2025,10.1016/j.ijbiomac.2025.140866,https://pubmed.ncbi.nlm.nih.gov/39955956/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,37499712,Genome-scale CRISPR screen identifies TRIM2 and SLC35A1 associated with porcine epidemic diarrhoea virus infection.,2023,10.1016/j.ijbiomac.2023.125962,https://pubmed.ncbi.nlm.nih.gov/37499712/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,36746519,Distinct transcriptional signatures in purified circulating immune cells drive heterogeneity in disease location in IBD.,2023,10.1136/bmjgast-2022-001003,https://pubmed.ncbi.nlm.nih.gov/36746519/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,30834435,Functional analyses of the UDP-galactose transporter SLC35A2 using the binding of bacterial Shiga toxins as a novel activity assay.,2019,10.1093/glycob/cwz016,https://pubmed.ncbi.nlm.nih.gov/30834435/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,27642072,Genetic engineering of CHO cells for viral resistance to minute virus of mice.,2017,10.1002/bit.26186,https://pubmed.ncbi.nlm.nih.gov/27642072/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,31462968,Nucleotide Sugar Transporter SLC35 Family Structure and Function.,2019,10.1016/j.csbj.2019.08.002,https://pubmed.ncbi.nlm.nih.gov/31462968/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC35A1,ENSG00000164414,Unsafe,22989990,"CHO-gmt5, a novel CHO glycosylation mutant for producing afucosylated and asialylated recombinant antibodies.",2013,10.4161/bioe.22262,https://pubmed.ncbi.nlm.nih.gov/22989990/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,41811103,SLC38A9 Regulation Affects Hippocampal Neuronal Autophagy: A Potential Alzheimer's Therapeutic Approach by Suppressing Alzheimer's Disease-Related Protein Deposition.,2026,10.1002/cns.70823,https://pubmed.ncbi.nlm.nih.gov/41811103/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,42070976,pH-mediated activation of the lysosomal arginine sensor SLC38A9.,2026,10.1002/1873-3468.70352,https://pubmed.ncbi.nlm.nih.gov/42070976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,42186568,"Lysosomal protein SLC38A9 regulates arginine-mediated autophagy, ER stress, and apoptosis in abalone &lt;i&gt;Haliotis discus hannai&lt;/i&gt;.",2026,10.1007/s42995-025-00348-z,https://pubmed.ncbi.nlm.nih.gov/42186568/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,40613244,mTORC1 Selective Nano-Inhibitor by Disrupting the Lysosomal Arginine-SLC38A9- mTORC1-CDKs Axis for Precision Bladder Cancer Therapy.,2025,10.1002/adma.202504798,https://pubmed.ncbi.nlm.nih.gov/40613244/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,41311398,A small-molecule anti-cancer drug for long-acting lysosomal damage.,2025,10.1016/j.apsb.2025.09.005,https://pubmed.ncbi.nlm.nih.gov/41311398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,40448242,"Proteome profile differences among human, monkey, and mouse brain microvessels and cultured brain microvascular endothelial cells.",2025,10.1186/s12987-025-00650-z,https://pubmed.ncbi.nlm.nih.gov/40448242/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,38638435,Arginine alleviates &lt;i&gt;Clostridium perfringens&lt;/i&gt; α toxin-induced intestinal injury &lt;i&gt;in vivo&lt;/i&gt; and &lt;i&gt;in vitro&lt;/i&gt; via the SLC38A9/mTORC1 pathway.,2024,10.3389/fimmu.2024.1357072,https://pubmed.ncbi.nlm.nih.gov/38638435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,41461269,Amino Acid Signaling in Skeletal Muscle Is Blunted by Prematurity in a Piglet Model.,2026,10.1016/j.tjnut.2025.101303,https://pubmed.ncbi.nlm.nih.gov/41461269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,39071889,SLC38A9 regulates SARS-CoV-2 viral entry.,2024,10.1016/j.isci.2024.110387,https://pubmed.ncbi.nlm.nih.gov/39071889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,40509034,Dietary Supplementation of &lt;i&gt;Lactobacillus reuteri&lt;/i&gt; Modulates Amino Acid Metabolism and Extracellular Matrix in the Gut-Liver Axis of Weaned Piglets.,2025,10.3390/ani15111567,https://pubmed.ncbi.nlm.nih.gov/40509034/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,38142034,The SLC38A9-mTOR axis is involved in autophagy in the juvenile yellow catfish (Pelteobagrus fulvidraco) under ammonia stress.,2024,10.1016/j.envpol.2023.123211,https://pubmed.ncbi.nlm.nih.gov/38142034/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,37953772,"RBM25 binds to and regulates alternative splicing levels of &lt;i&gt;Slc38a9, Csf1,&lt;/i&gt; and &lt;i&gt;Coro6&lt;/i&gt; to affect immune and inflammatory processes in H9c2 cells.",2023,10.7717/peerj.16312,https://pubmed.ncbi.nlm.nih.gov/37953772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,33743841,D-Tryptophan enhances the reproductive organ-specific expression of the amino acid transporter homolog Dr-SLC38A9 involved in the sexual induction of planarian Dugesia ryukyuensis.,2021,10.1186/s40851-021-00173-z,https://pubmed.ncbi.nlm.nih.gov/33743841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,35457018,Slc38a9 Deficiency Induces Apoptosis and Metabolic Dysregulation and Leads to Premature Death in Zebrafish.,2022,10.3390/ijms23084200,https://pubmed.ncbi.nlm.nih.gov/35457018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,34685533,Arginine Regulates TOR Signaling Pathway through SLC38A9 in Abalone Haliotis discus hannai.,2021,10.3390/cells10102552,https://pubmed.ncbi.nlm.nih.gov/34685533/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,36364703,"The Genetic Variability of Members of the SLC38 Family of Amino Acid Transporters (SLC38A3, SLC38A7 and SLC38A9) Affects Susceptibility to Type 2 Diabetes and Vascular Complications.",2022,10.3390/nu14214440,https://pubmed.ncbi.nlm.nih.gov/36364703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,39163330,Rag-Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway.,2024,10.1073/pnas.2322755121,https://pubmed.ncbi.nlm.nih.gov/39163330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,38166559,Sex differences in response to obesity and caloric restriction on cognition and hippocampal measures of autophagic-lysosomal transcripts and signaling pathways.,2024,10.1186/s12868-023-00840-1,https://pubmed.ncbi.nlm.nih.gov/38166559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,34572527,Insights into the Interaction of Lysosomal Amino Acid Transporters SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in C2C12 Cells.,2021,10.3390/biom11091314,https://pubmed.ncbi.nlm.nih.gov/34572527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,34246831,Identification of amino acid response element of SLC38A9 as an ATF4-binding site in porcine skeletal muscle cells.,2021,10.1016/j.bbrc.2021.06.083,https://pubmed.ncbi.nlm.nih.gov/34246831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,33296665,A conformational change in the N terminus of SLC38A9 signals mTORC1 activation.,2021,10.1016/j.str.2020.11.014,https://pubmed.ncbi.nlm.nih.gov/33296665/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,39145096,Identifying key pathogenic mechanisms and potential intervention targets for recurrence after laryngeal cancer treatment through bioinformatics screening.,2024,10.21037/tcr-24-1015,https://pubmed.ncbi.nlm.nih.gov/39145096/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,37239413,Single-Locus and Multi-Locus Genome-Wide Association Studies Identify Genes Associated with Liver Cu Concentration in Merinoland Sheep.,2023,10.3390/genes14051053,https://pubmed.ncbi.nlm.nih.gov/37239413/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,36906952,Cholesterol confers ferroptosis resistance onto myeloid-biased hematopoietic stem cells and prevents irradiation-induced myelosuppression.,2023,10.1016/j.redox.2023.102661,https://pubmed.ncbi.nlm.nih.gov/36906952/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,34095122,Arginine Metabolism and Its Potential in Treatment of Colorectal Cancer.,2021,10.3389/fcell.2021.658861,https://pubmed.ncbi.nlm.nih.gov/34095122/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,35111801,The Amino Acids Sensing and Utilization in Response to Dietary Aromatic Amino Acid Supplementation in LPS-Induced Inflammation Piglet Model.,2021,10.3389/fnut.2021.819835,https://pubmed.ncbi.nlm.nih.gov/35111801/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,30956113,Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling.,2019,10.1016/j.cmet.2019.03.005,https://pubmed.ncbi.nlm.nih.gov/30956113/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,35174346,"Effect of hyperthermia on cell viability, amino acid transfer, and milk protein synthesis in bovine mammary epithelial cells.",2022,10.5187/jast.2021.e128,https://pubmed.ncbi.nlm.nih.gov/35174346/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,35111166,Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55-IL6ST Gene Region in Immature Dendritic Cells.,2021,10.3389/fimmu.2021.816930,https://pubmed.ncbi.nlm.nih.gov/35111166/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,35230915,The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3.,2022,10.1080/15548627.2022.2029671,https://pubmed.ncbi.nlm.nih.gov/35230915/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,34827885,"Effect of Heat Stress on Bovine Mammary Cellular Metabolites and Gene Transcription Related to Amino Acid Metabolism, Amino Acid Transportation and Mammalian Target of Rapamycin (mTOR) Signaling.",2021,10.3390/ani11113153,https://pubmed.ncbi.nlm.nih.gov/34827885/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,29248224,"Varying the ratio of Lys:Met while maintaining the ratios of Thr:Phe, Lys:Thr, Lys:His, and Lys:Val alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription.",2018,10.3168/jds.2017-13351,https://pubmed.ncbi.nlm.nih.gov/29248224/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,28503190,"Essential amino acid ingestion alters expression of genes associated with amino acid sensing, transport, and mTORC1 regulation in human skeletal muscle.",2017,10.1186/s12986-017-0187-1,https://pubmed.ncbi.nlm.nih.gov/28503190/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,27609023,A 19-Gene expression signature as a predictor of survival in colorectal cancer.,2016,10.1186/s12920-016-0218-1,https://pubmed.ncbi.nlm.nih.gov/27609023/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC38A9,ENSG00000177058,Unsafe,24762746,New genetic biomarkers predicting azathioprine blood concentrations in combination therapy with 5-aminosalicylic acid.,2014,10.1371/journal.pone.0095080,https://pubmed.ncbi.nlm.nih.gov/24762746/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,40540401,Choline transporters are required for oligodendrocyte differentiation and myelin sheath formation in mouse postnatal brain.,2025,10.1016/j.celrep.2025.115852,https://pubmed.ncbi.nlm.nih.gov/40540401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,42241629,Transcriptome dissection reveals shared upregulated genes and enriched pathways involved in skin disease concurrence.,2026,,https://pubmed.ncbi.nlm.nih.gov/42241629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,41605187,Regulation of Lipid Biology-Associated Gene Expression in Granulosa Cells in Hyperandrogenic PCOS: A Possible Link Between Dyslipidemia and Hyperandrogenism.,2026,10.1002/lipd.70035,https://pubmed.ncbi.nlm.nih.gov/41605187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,38466119,Predicting Functional Consequences of Recent Natural Selection in Britain.,2024,10.1093/molbev/msae053,https://pubmed.ncbi.nlm.nih.gov/38466119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,37540584,Functional characterization of Bombyx mori (Lepidoptera: Bombycidae) C-type lectin 5.,2023,10.1093/jee/toad142,https://pubmed.ncbi.nlm.nih.gov/37540584/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,40873762,Machine Learning-Driven Prediction Models for Brodalumab Therapeutic Effect and Response Speed in Plaque Psoriasis.,2025,10.2147/ptt.s531925,https://pubmed.ncbi.nlm.nih.gov/40873762/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,40972734,"Diversity of human choline transporters: substrate specificity, kinetic properties, and inhibitor sensitivity.",2025,10.1016/j.bcp.2025.117343,https://pubmed.ncbi.nlm.nih.gov/40972734/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,35067776,Gene expression profiling using targeted RNA-sequencing to elucidate the progression from histologically normal lung tissues to non-invasive lesions in invasive lung adenocarcinoma.,2022,10.1007/s00428-021-03250-y,https://pubmed.ncbi.nlm.nih.gov/35067776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,41091165,Differentiating the demographic histories and local adaptations of middle-altitude Qiang and Tibetan people.,2025,10.1007/s00439-025-02784-4,https://pubmed.ncbi.nlm.nih.gov/41091165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,35580964,"Comparison of biochemical, microbial and mucosal mRNA expression in bile acid diarrhoea and irritable bowel syndrome with diarrhoea.",2023,10.1136/gutjnl-2022-327471,https://pubmed.ncbi.nlm.nih.gov/35580964/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,38200769,Genome-Wide Association Study for Somatic Skeletal Traits in Duroc × (Landrace × Yorkshire) Pigs.,2023,10.3390/ani14010037,https://pubmed.ncbi.nlm.nih.gov/38200769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,35211402,Case Report: Pathological Complete Response in a Lung Metastasis of Phyllodes Tumor Patient Following Treatment Containing Peptide Neoantigen Nano-Vaccine.,2022,10.3389/fonc.2022.800484,https://pubmed.ncbi.nlm.nih.gov/35211402/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,33206936,Genomic and transcriptomic correlates of Richter transformation in chronic lymphocytic leukemia.,2021,10.1182/blood.2020005650,https://pubmed.ncbi.nlm.nih.gov/33206936/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,27082540,Knockdown by shRNA identifies SLC44A5 as a potential therapeutic target in hepatocellular carcinoma.,2016,10.3892/mmr.2016.5136,https://pubmed.ncbi.nlm.nih.gov/27082540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,30375717,Involvement of dual-strand of the miR-144 duplex and their targets in the pathogenesis of lung squamous cell carcinoma.,2019,10.1111/cas.13853,https://pubmed.ncbi.nlm.nih.gov/30375717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,22815983,"The molecular effects of a polymorphism in the 5'UTR of solute carrier family 44, member 5 that is associated with birth weight in Holsteins.",2012,10.1371/journal.pone.0041267,https://pubmed.ncbi.nlm.nih.gov/22815983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,34095189,Dietary Choline-Enhanced Skin Immune Response of Juvenile Grass Carp Might Be Related to the STAT3 and NF-kB Signaling Pathway (Ctenopharyngodon idella).,2021,10.3389/fnut.2021.652767,https://pubmed.ncbi.nlm.nih.gov/34095189/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,29610366,Exome chip analyses identify genes affecting mortality after HLA-matched unrelated-donor blood and marrow transplantation.,2018,10.1182/blood-2017-11-817973,https://pubmed.ncbi.nlm.nih.gov/29610366/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,25256443,Membrane transport mechanisms of choline in human intestinal epithelial LS180 cells.,2014,10.1002/bdd.1917,https://pubmed.ncbi.nlm.nih.gov/25256443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,21311593,Neuronal genes for subcutaneous fat thickness in human and pig are identified by local genomic sequencing and combined SNP association study.,2011,10.1371/journal.pone.0016356,https://pubmed.ncbi.nlm.nih.gov/21311593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC44A5,ENSG00000137968,Unsafe,8864171,Tumor associated antigens in human renal cell carcinoma: MHC restricted recognition by cytotoxic T lymphocytes.,1996,10.1111/j.1399-0039.1996.tb02601.x,https://pubmed.ncbi.nlm.nih.gov/8864171/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,39317184,The sodium-bicarbonate cotransporter Slc4a5 mediates feedback at the first synapse of vision.,2024,10.1016/j.neuron.2024.08.015,https://pubmed.ncbi.nlm.nih.gov/39317184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,40444624,Effect of Electroacupuncture on Intestinal Mucosal Barrier in IBS-D Rats: Analysis Based on RNA-seq.,2026,10.2174/0113862073395229250513074835,https://pubmed.ncbi.nlm.nih.gov/40444624/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,40795418,Multi-omics profiling of hepatic macromolecules in laying hens with difference feed intake: Mechanistic insights into antioxidant capacity modulation.,2025,10.1016/j.psj.2025.105575,https://pubmed.ncbi.nlm.nih.gov/40795418/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,35216333,A Splicing Mutation in Slc4a5 Results in Retinal Detachment and Retinal Pigment Epithelium Dysfunction.,2022,10.3390/ijms23042220,https://pubmed.ncbi.nlm.nih.gov/35216333/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,38493246,Analysis of the finasteride treatment and its withdrawal in the rat hypothalamus and hippocampus at whole-transcriptome level.,2024,10.1007/s40618-024-02345-y,https://pubmed.ncbi.nlm.nih.gov/38493246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,32547422,NBCe2 (Slc4a5) Is Expressed in the Renal Connecting Tubules and Cortical Collecting Ducts and Mediates Base Extrusion.,2020,10.3389/fphys.2020.00560,https://pubmed.ncbi.nlm.nih.gov/32547422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,27628629,The Renal Sodium Bicarbonate Cotransporter NBCe2: Is It a Major Contributor to Sodium and pH Homeostasis?,2016,10.1007/s11906-016-0679-9,https://pubmed.ncbi.nlm.nih.gov/27628629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,29642240,Sodium bicarbonate cotransporter NBCe2 gene variants increase sodium and bicarbonate transport in human renal proximal tubule cells.,2018,10.1371/journal.pone.0189464,https://pubmed.ncbi.nlm.nih.gov/29642240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,35150959,Targeting hypoxia regulated sodium driven bicarbonate transporters reduces triple negative breast cancer metastasis.,2022,10.1016/j.neo.2022.01.003,https://pubmed.ncbi.nlm.nih.gov/35150959/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,30541599,Choroid plexus genes for CSF production and brain homeostasis are altered in Alzheimer's disease.,2018,10.1186/s12987-018-0120-7,https://pubmed.ncbi.nlm.nih.gov/30541599/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,36980585,Interactions of SNPs in Folate Metabolism Related Genes on Prostate Cancer Aggressiveness in European Americans and African Americans.,2023,10.3390/cancers15061699,https://pubmed.ncbi.nlm.nih.gov/36980585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,26447209,The sodium-bicarbonate cotransporter NBCe2 (slc4a5) expressed in human renal proximal tubules shows increased apical expression under high-salt conditions.,2015,10.1152/ajpregu.00150.2015,https://pubmed.ncbi.nlm.nih.gov/26447209/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,24155723,Na(+) dependent acid-base transporters in the choroid plexus; insights from slc4 and slc9 gene deletion studies.,2013,10.3389/fphys.2013.00304,https://pubmed.ncbi.nlm.nih.gov/24155723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,22082831,Targeted mutation of SLC4A5 induces arterial hypertension and renal metabolic acidosis.,2012,10.1093/hmg/ddr533,https://pubmed.ncbi.nlm.nih.gov/22082831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,30105963,Genetic predisposition to salt-sensitive normotension and its effects on salt taste perception and intake.,2018,10.1017/s0007114518002027,https://pubmed.ncbi.nlm.nih.gov/30105963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,29956324,The choroid plexus sodium-bicarbonate cotransporter NBCe2 regulates mouse cerebrospinal fluid pH.,2018,10.1113/jp275489,https://pubmed.ncbi.nlm.nih.gov/29956324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,21705333,Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene).,2011,10.1074/jbc.m111.249961,https://pubmed.ncbi.nlm.nih.gov/21705333/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,26556046,The Effect of Acute and Chronic Social Stress on the Hippocampal Transcriptome in Mice.,2015,10.1371/journal.pone.0142195,https://pubmed.ncbi.nlm.nih.gov/26556046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,19384345,"Functional identification of the promoter of SLC4A5, a gene associated with cardiovascular and metabolic phenotypes in the HERITAGE Family Study.",2009,10.1038/ejhg.2009.64,https://pubmed.ncbi.nlm.nih.gov/19384345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,25428855,Cation-coupled bicarbonate transporters.,2014,10.1002/cphy.c130005,https://pubmed.ncbi.nlm.nih.gov/25428855/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,22987918,Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter.,2012,10.1161/hypertensionaha.112.196071,https://pubmed.ncbi.nlm.nih.gov/22987918/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,26582410,Common variants in the Na(+)-coupled bicarbonate transporter genes and salt sensitivity of blood pressure: the GenSalt study.,2016,10.1038/jhh.2015.113,https://pubmed.ncbi.nlm.nih.gov/26582410/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,17715183,Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues.,2007,10.1152/ajpregu.00356.2007,https://pubmed.ncbi.nlm.nih.gov/17715183/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,11788353,Functional characterization of NBC4: a new electrogenic sodium-bicarbonate cotransporter.,2002,10.1152/ajpcell.00409.2001,https://pubmed.ncbi.nlm.nih.gov/11788353/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,10978526,"Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family.",2000,10.1016/s0167-4781(00)00149-4,https://pubmed.ncbi.nlm.nih.gov/10978526/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC4A5,ENSG00000188687,Unsafe,11087115,"Two C-terminal variants of NBC4, a new member of the sodium bicarbonate cotransporter family: cloning, characterization, and localization.",2000,10.1080/15216540050176539,https://pubmed.ncbi.nlm.nih.gov/11087115/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,42353828,A Comprehensive Bioinformatic Analysis of SLC52A3 as a Prognostic Biomarker and Potential Therapeutic Target in Gynecological Cancers.,2026,10.3390/genes17060669,https://pubmed.ncbi.nlm.nih.gov/42353828/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,42787692,SLC52A3-Related Riboflavin Transporter Deficiency in Two Saudi Siblings: A Case Report.,2026,10.7759/cureus.115131,https://pubmed.ncbi.nlm.nih.gov/42787692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,42799589,Biomarker-Guided Diagnosis of Riboflavin Transporter Deficiency Presenting as Seronegative Myasthenia Gravis: A Short Report from a Consanguineous Family.,2026,10.1177/19450265261493084,https://pubmed.ncbi.nlm.nih.gov/42799589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,39656631,Development of a riboflavin-responsive model of riboflavin transporter deficiency in zebrafish.,2025,10.1093/hmg/ddae171,https://pubmed.ncbi.nlm.nih.gov/39656631/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,42056474,SLC52A3-related Brown-Vialetto-Van Laere syndrome: a large cohort from the Arabian Peninsula.,2026,10.1038/s41431-026-02106-w,https://pubmed.ncbi.nlm.nih.gov/42056474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,42826312,Excellent response to high-dose Riboflavin in Brown-Vialetto-Van Laere syndrome: A case report.,2026,10.1097/md.0000000000051027,https://pubmed.ncbi.nlm.nih.gov/42826312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,40603088,Identification and Physiological Analysis of Novel Riboflavin Transporter RFVT.,2025,10.1248/bpb.b25-00194,https://pubmed.ncbi.nlm.nih.gov/40603088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,41272437,Identification and Functional Validation of the Role of Solute Carriers in Shaping Xenobiotic Tolerance in Polyphagous Pests of &lt;i&gt;Spodoptera litura&lt;/i&gt;.,2025,10.1021/acs.jafc.5c12376,https://pubmed.ncbi.nlm.nih.gov/41272437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,39144563,MicroPET Imaging of Riboflavin Transporter 3 Expression in Myocardial Infarction/Reperfusion Rat Models with Radiofluorinated Riboflavin.,2024,10.1021/acsptsci.4c00175,https://pubmed.ncbi.nlm.nih.gov/39144563/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,40307217,Structure and transport mechanism of human riboflavin transporters.,2025,10.1038/s41467-025-59255-7,https://pubmed.ncbi.nlm.nih.gov/40307217/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,40787273,Brown-Vialetto-Van Laere Syndrome: Case Report of Dramatic Response to Riboflavin.,2025,10.22037/ijcn.v19i3.46308,https://pubmed.ncbi.nlm.nih.gov/40787273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,40471388,Transcriptional characterization of sepsis in a LPS porcine model.,2025,10.1007/s00438-025-02261-7,https://pubmed.ncbi.nlm.nih.gov/40471388/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,41617437,Alteration of Flavin Homeostasis in Uterine Cancer.,2026,10.21873/anticanres.17978,https://pubmed.ncbi.nlm.nih.gov/41617437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,40539137,Long-Term Survival in Brown-Vialetto-Van Laere Syndrome: A Case Report Highlighting Respiratory Care.,2025,10.7759/cureus.84491,https://pubmed.ncbi.nlm.nih.gov/40539137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,41784817,Amino acid metabolism-related model for prognosis and immunity in gastric cancer.,2026,10.1007/s00726-026-03507-3,https://pubmed.ncbi.nlm.nih.gov/41784817/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,39279392,Development and Evaluation of [&lt;sup&gt;68&lt;/sup&gt;Ga]Ga-Labeled Riboflavin Derivative for RFVT3-Targeted PET Imaging of Melanoma in Mice.,2024,10.1021/acs.molpharmaceut.4c00209,https://pubmed.ncbi.nlm.nih.gov/39279392/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,33116204,Effect of riboflavin deficiency on development of the cerebral cortex in Slc52a3 knockout mice.,2020,10.1038/s41598-020-75601-9,https://pubmed.ncbi.nlm.nih.gov/33116204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,39234898,Rare Diseases Linked to Mutations in Vitamin Transporters Expressed in the Human Blood-Brain Barrier.,2024,10.1002/cpt.3433,https://pubmed.ncbi.nlm.nih.gov/39234898/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,42104168,Leveraging mitochondrial dynamics-related risk signatures to predict the prognosis and tumor microenvironment of lung adenocarcinoma.,2026,10.1007/s12672-026-05038-5,https://pubmed.ncbi.nlm.nih.gov/42104168/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,40168907,Brown-Vialetto-Van Laere syndrome patients with unusual phenotypes from Indian ethnicity: Functional analysis of clinical variants in SLC52A2 and SLC52A3 genes.,2025,10.1016/j.braindev.2025.104355,https://pubmed.ncbi.nlm.nih.gov/40168907/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,42838046,Cancer competition for vitamin B2 creates metabolic checkpoint for T cell ferroptosis.,2026,10.1016/j.cell.2026.09.020,https://pubmed.ncbi.nlm.nih.gov/42838046/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,42367221,"Based on comprehensive analysis of ScRNA-seq and bulk RNA-seq, identification of palmitoylation-related genes as biomarkers to evaluate prognosis and immune landscape in stomach adenocarcinoma.",2026,10.1007/s10616-026-01014-7,https://pubmed.ncbi.nlm.nih.gov/42367221/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,38234923,KLK10/LIPH/PARD6B/SLC52A3 are promising molecular biomarkers for the prognosis of pancreatic cancer through a ceRNA network.,2024,10.1016/j.heliyon.2024.e24287,https://pubmed.ncbi.nlm.nih.gov/38234923/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,35549728,Defective expression of C20orf54 in esophageal dysplasia: a possible biomarker of esophageal carcinoma for early detection.,2022,10.1186/s12957-022-02612-3,https://pubmed.ncbi.nlm.nih.gov/35549728/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,38430255,Riboflavin-LSD1 axis participates in the in vivo tumor-associated macrophage morphology in human colorectal liver metastases.,2024,10.1007/s00262-024-03645-1,https://pubmed.ncbi.nlm.nih.gov/38430255/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,39023044,Genome-wide meta-analysis identifies ancestry-specific loci for Alzheimer's disease.,2024,10.1002/alz.14121,https://pubmed.ncbi.nlm.nih.gov/39023044/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,38745833,Case Report: A rare treatable metabolic syndrome (Brown-Vialetto-Van Laere syndrome) masquerading as chronic inflammatory demyelinating polyneuropathy from Saudi Arabia.,2024,10.3389/fped.2024.1377515,https://pubmed.ncbi.nlm.nih.gov/38745833/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,41295274,Riboflavin Transporter Deficiency as a Cause of Progressive Encephalopathy.,2025,10.3390/metabo15110688,https://pubmed.ncbi.nlm.nih.gov/41295274/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,38968825,Fluoride induces immunotoxicity by regulating riboflavin transport and metabolism partly through IL-17A in the spleen.,2024,10.1016/j.jhazmat.2024.135085,https://pubmed.ncbi.nlm.nih.gov/38968825/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,34395718,To Be or No B2: A Rare Cause of Stridor and Weakness in a Toddler.,2021,10.1177/2329048x211030723,https://pubmed.ncbi.nlm.nih.gov/34395718/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,36355094,"A New Mechanism for Ginsenoside Rb1 to Promote Glucose Uptake, Regulating Riboflavin Metabolism and Redox Homeostasis.",2022,10.3390/metabo12111011,https://pubmed.ncbi.nlm.nih.gov/36355094/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,34853602,A Transcription Factor-Based Risk Model for Predicting the Prognosis of Prostate Cancer and Potential Therapeutic Drugs.,2021,10.1155/2021/6894278,https://pubmed.ncbi.nlm.nih.gov/34853602/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,32685482,Prognostic Value and Immune Infiltrates of ABCA8 and FABP4 in Stomach Adenocarcinoma.,2020,10.1155/2020/4145164,https://pubmed.ncbi.nlm.nih.gov/32685482/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,32022482,A juvenile ALS-like phenotype dramatically improved after high-dose riboflavin treatment.,2020,10.1002/acn3.50977,https://pubmed.ncbi.nlm.nih.gov/32022482/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC52A3,ENSG00000101276,Unsafe,20463145,Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain.,2010,10.3945/jn.110.122911,https://pubmed.ncbi.nlm.nih.gov/20463145/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A16,ENSG00000063127,Unsafe,42231301,Prospective germline exome and machine learning-based risk score identify predictive and prognostic biomarkers of immunotherapy outcomes in advanced non-small cell lung cancer.,2026,10.1186/s12967-026-08374-w,https://pubmed.ncbi.nlm.nih.gov/42231301/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A16,ENSG00000063127,Unsafe,27134767,Genome-wide time-to-event analysis on smoking progression stages in a family-based study.,2016,10.1002/brb3.462,https://pubmed.ncbi.nlm.nih.gov/27134767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A16,ENSG00000063127,Unsafe,25750709,"Expression of drug transporters in human kidney: impact of sex, age, and ethnicity.",2015,10.1186/s13293-015-0020-3,https://pubmed.ncbi.nlm.nih.gov/25750709/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A16,ENSG00000063127,Unsafe,11112352,Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl- -dependent neurotransmitter transporter gene family.,2000,10.1006/geno.2000.6387,https://pubmed.ncbi.nlm.nih.gov/11112352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,41703440,"Slc6a9 is distributed in glial cells and neurons across several nervous system regions, whereas Slc6a5 is more restricted to neurons in the caudal brain.",2026,10.1186/s12868-026-00999-3,https://pubmed.ncbi.nlm.nih.gov/41703440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,42491336,Targeting the NAT1-ENO1-Lactate Axis Destabilizes PD-L1 to Reinvigorate Antitumor Immunity in Colorectal Cancer.,2026,10.1002/mco2.70867,https://pubmed.ncbi.nlm.nih.gov/42491336/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,42665691,Propofol regulates SLC6A2 expression via NAT10-mediated ac4C modification to modulate excessive mitophagy and hippocampal neuron dysfunction in aged postoperative cognitive dysfunction.,2026,10.1007/s00210-026-05839-z,https://pubmed.ncbi.nlm.nih.gov/42665691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,42247510,Regulation of NAT1 activity in modern humans by a novel phosphorylation site.,2026,10.1126/sciadv.ady1666,https://pubmed.ncbi.nlm.nih.gov/42247510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,42719741,Unveiling the molecular toxicity of plasticizers derived from microplastics (DMP and DEP) in diabetic kidney disease: integrative insights from network toxicology and multi-omics analysis.,2026,10.3389/fimmu.2026.1918728,https://pubmed.ncbi.nlm.nih.gov/42719741/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,42510976,Carnosic Acid Attenuates TNF-α-Induced Insulin Resistance by Regulating Mitochondrial Function in 3T3-L1 Adipocytes.,2026,10.3390/cimb48070736,https://pubmed.ncbi.nlm.nih.gov/42510976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,42589662,The Pharmacogenomics of Opioid Response in Cancer Pain: From Receptor Polymorphisms to Tumour-Mediated Interference-A Narrative-Critical Review.,2026,10.3390/ijms27157011,https://pubmed.ncbi.nlm.nih.gov/42589662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,42624950,Antisense oligonucleotide-mediated disruption of mRNA localisation inhibits angiogenesis.,2026,10.1007/s10456-026-10087-z,https://pubmed.ncbi.nlm.nih.gov/42624950/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,42651827,"Cross-Cohort, Renal Compartment-Aware Transcriptomic Assessment of Lycii Fructus-Annotated Targets in Diabetic Kidney Disease.",2026,10.3390/cimb48080829,https://pubmed.ncbi.nlm.nih.gov/42651827/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,42722212,"Integrative network toxicology, molecular docking, and in vitro experiments identify SLC6A2 as a novel candidate target in nicotine-induced osteoporosis.",2026,10.1016/j.exger.2026.113316,https://pubmed.ncbi.nlm.nih.gov/42722212/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,41943069,Activation of the NR3C1-STAT3-SLC6A2 signaling axis by a cyanidin-3-O-glucoside-enriched anthocyanin preparation attenuates neuroinflammation and pain hypersensitivity in intervertebral disc degeneration.,2026,10.1186/s12974-026-03791-6,https://pubmed.ncbi.nlm.nih.gov/41943069/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,41723107,Cancer-associated fibroblasts promote osimertinib resistance in non-small cell lung cancer cells via METTL1-mediated NET1 m&lt;sup&gt;7&lt;/sup&gt;G modification.,2026,10.1038/s41419-026-08505-7,https://pubmed.ncbi.nlm.nih.gov/41723107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,42163165,Gene expression meta-analysis in the prefrontal cortex: unraveling biological underpinnings of suicidal risk.,2026,10.1186/s12888-026-08170-2,https://pubmed.ncbi.nlm.nih.gov/42163165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,42450020,"Association of Selected Genetic Variants in CYP1A1, CYP2D6, NAT1 and NAT2 with Endometrial Cancer Risk: A Preliminary Case-Control Study.",2026,10.3390/ijms27135747,https://pubmed.ncbi.nlm.nih.gov/42450020/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,42621018,Integrated non-targeted and targeted metabolomics reveals tryptophan metabolism disorders in hypertension.,2026,10.3389/fcvm.2026.1805381,https://pubmed.ncbi.nlm.nih.gov/42621018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,41492199,Tabersonine Alleviates Cerebral Ischemia/Reperfusion Injury Partly via Repressing the SLC6A2/NF-κB Signalling Pathway.,2026,10.1111/1440-1681.70101,https://pubmed.ncbi.nlm.nih.gov/41492199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,41449633,The Role of the RhoA Activating Protein Net1 in Cancer Initiation and Progression.,2026,10.1080/10985549.2025.2605086,https://pubmed.ncbi.nlm.nih.gov/41449633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,41975102,GlyT1 (SLC6A9) inhibition in neurological and psychiatric disorders.,2026,10.1007/s00210-026-05276-y,https://pubmed.ncbi.nlm.nih.gov/41975102/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,39747410,Multiomics analysis reveals the involvement of NET1 in tumour immune regulation and malignant progression.,2025,10.1038/s41598-024-83714-8,https://pubmed.ncbi.nlm.nih.gov/39747410/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,40473627,Control of epithelial tissue organization by mRNA localization.,2025,10.1038/s41467-025-60532-8,https://pubmed.ncbi.nlm.nih.gov/40473627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,42101172,Pharmacogenetics of venlafaxine response in older adults with depression and chronic lower back pain.,2026,10.1080/14622416.2026.2669395,https://pubmed.ncbi.nlm.nih.gov/42101172/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,41187610,"Apixaban kinetics could be influenced by sex, cytochrome P450 enzymes and SLC6A2 transporter.",2025,10.1016/j.biopha.2025.118732,https://pubmed.ncbi.nlm.nih.gov/41187610/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,40329330,Investigating the mechanisms by which low NAT1 expression in tumor cells contributes to chemo-resistance in colorectal cancer.,2025,10.1186/s13148-025-01882-4,https://pubmed.ncbi.nlm.nih.gov/40329330/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,40592148,Investigation of potential toxicity associated with long-term amitriptyline exposure: Evidence from genomics.,2025,10.1016/j.ecoenv.2025.118587,https://pubmed.ncbi.nlm.nih.gov/40592148/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,41306765,Arylamine N-Acetyltransferase 1 Knockout in Immortalized Human Bronchial Cells Results in a Reduction of Cellular Growth.,2025,10.1016/j.genrep.2025.102332,https://pubmed.ncbi.nlm.nih.gov/41306765/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,40981114,The Role of Pharmacogenomics in Optimizing Ketamine Therapy for Post-Amputation Pain.,2025,10.3390/reports8030156,https://pubmed.ncbi.nlm.nih.gov/40981114/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,41344065,N-acetyltransferase (NAT) 1 and NAT2 enzyme activities drive interindividual variability in sulfamethoxazole N-acetylation.,2025,10.1016/j.dmd.2025.100195,https://pubmed.ncbi.nlm.nih.gov/41344065/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,41742646,Ultrasound-Responsive Serotonylation and Hallmark Pathway Gene Signatures Reveal Tumor Microenvironment Vulnerabilities and Prognostic Subtypes in Colorectal Cancer.,2026,10.1177/10849785261422976,https://pubmed.ncbi.nlm.nih.gov/41742646/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,39204422,"Genetic Variation in CYP2D6, UGT1A4, SLC6A2 and SLCO1B1 Alters the Pharmacokinetics and Safety of Mirabegron.",2024,10.3390/pharmaceutics16081077,https://pubmed.ncbi.nlm.nih.gov/39204422/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,41263065,MCT8 Modulates Metabolite Uptake and T-cell Exhaustion to Promote Immunosuppression and Tumor Progression in Hepatocellular Carcinoma.,2026,10.1158/1535-7163.mct-25-0564,https://pubmed.ncbi.nlm.nih.gov/41263065/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC6A2,ENSG00000103546,Unsafe,39144569,Small Molecule Inhibitors of Arylamine N-Acetyltransferase 1 Attenuate Cellular Respiration.,2024,10.1021/acsptsci.4c00282,https://pubmed.ncbi.nlm.nih.gov/39144569/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,37834431,Na+/H+ Exchangers (NHEs) in Mammalian Sperm: Essential Contributors to Male Fertility.,2023,10.3390/ijms241914981,https://pubmed.ncbi.nlm.nih.gov/37834431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,41467369,Potential Risk Factors and Therapeutic Targets for Dilated Cardiomyopathy Identified Through Mendelian Randomization Analysis.,2026,10.1161/jaha.124.038088,https://pubmed.ncbi.nlm.nih.gov/41467369/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,38927088,pH Homeodynamics and Male Fertility: A Coordinated Regulation of Acid-Based Balance during Sperm Journey to Fertilization.,2024,10.3390/biom14060685,https://pubmed.ncbi.nlm.nih.gov/38927088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,35694410,"The Less Well-Known Little Brothers: The SLC9B/NHA Sodium Proton Exchanger Subfamily-Structure, Function, Regulation and Potential Drug-Target Approaches.",2022,10.3389/fphys.2022.898508,https://pubmed.ncbi.nlm.nih.gov/35694410/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,40900730,Genetic predisposition to immune dysregulation and extracellular matrix remodeling in cardiac arrhythmia reveals potential mediation by &lt;i&gt;SPP1&lt;/i&gt;+ macrophages.,2025,10.3389/fcell.2025.1611663,https://pubmed.ncbi.nlm.nih.gov/40900730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,41792460,ENA1 deficiency attenuates Saccharomyces 'boulardii' probiotic yeast virulence in immunosuppressed mouse fungaemia model.,2026,10.1038/s42003-026-09763-z,https://pubmed.ncbi.nlm.nih.gov/41792460/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,41199725,Molecular mechanisms underpinning buoyancy control in the aquatic larvae of Chaoborus evolved from tracheal fluid clearing functionality.,2025,10.1242/jeb.251113,https://pubmed.ncbi.nlm.nih.gov/41199725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,41498801,Targeted analysis of whole exome sequencing in Thai patients with neonatal diabetes.,2026,10.1007/s00439-025-02815-0,https://pubmed.ncbi.nlm.nih.gov/41498801/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,36943876,NHA1 is a cation/proton antiporter essential for the water-conserving functions of the rectal complex in Tribolium castaneum.,2023,10.1073/pnas.2217084120,https://pubmed.ncbi.nlm.nih.gov/36943876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,41676957,Trafficking of the human Na&lt;sup&gt;+&lt;/sup&gt;/H&lt;sup&gt;+&lt;/sup&gt; antiporter NHA2 to the plasma membrane requires cornichon COPII cargo receptors.,2026,10.1002/pro.70492,https://pubmed.ncbi.nlm.nih.gov/41676957/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,41609903,Different sodium and potassium homeostasis patterns between rare and abundant microbial taxa in biological soil crusts revealed by metatranscriptomics.,2026,10.1007/s10534-026-00792-z,https://pubmed.ncbi.nlm.nih.gov/41609903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,25701605,Identification and characterization of methylation-dependent/independent DNA regulatory elements in the human SLC9B1 gene.,2015,10.1016/j.gene.2015.02.050,https://pubmed.ncbi.nlm.nih.gov/25701605/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,38328397,The yeast 14-3-3 proteins Bmh1 and Bmh2 regulate key signaling pathways.,2024,10.3389/fmolb.2024.1327014,https://pubmed.ncbi.nlm.nih.gov/38328397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,38396725,"Populus euphratica GRP2 Interacts with Target mRNAs to Negatively Regulate Salt Tolerance by Interfering with Photosynthesis, Na+, and ROS Homeostasis.",2024,10.3390/ijms25042046,https://pubmed.ncbi.nlm.nih.gov/38396725/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,38836370,The Role of Cornichons in the Biogenesis and Functioning of Monovalent-Cation Transport Systems.,2024,10.33549/physiolres.935406,https://pubmed.ncbi.nlm.nih.gov/38836370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,34946993,The Toxic Effects of Ppz1 Overexpression Involve Nha1-Mediated Deregulation of K+ and H+ Homeostasis.,2021,10.3390/jof7121010,https://pubmed.ncbi.nlm.nih.gov/34946993/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,38916228,"Comparative Whole-Genome Sequencing Analysis of In-situ and Invasive Acral Lentiginous Melanoma: Markedly Increased Copy Number Gains of GAB2 , PAK1 , UCP2 , and CCND1 are Associated with Melanoma Invasion.",2024,10.1097/pas.0000000000002273,https://pubmed.ncbi.nlm.nih.gov/38916228/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,28868326,Evolution of Vertebrate Solute Carrier Family 9B Genes and Proteins (SLC9B): Evidence for a Marsupial Origin for Testis Specific SLC9B1 from an Ancestral Vertebrate SLC9B2 Gene.,2016,10.4172/2329-9002.1000167,https://pubmed.ncbi.nlm.nih.gov/28868326/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,39465437,Whole-exome profiles of inflammatory breast cancer and pathological response to neoadjuvant chemotherapy.,2024,10.1186/s12967-024-05790-8,https://pubmed.ncbi.nlm.nih.gov/39465437/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,32054438,"Population-specific, recent positive directional selection suggests adaptation of human male reproductive genes to different environmental conditions.",2020,10.1186/s12862-019-1575-0,https://pubmed.ncbi.nlm.nih.gov/32054438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,38053573,The Hrk1 kinase is a determinant of acetic acid tolerance in yeast by modulating H+ and K+ homeostasis.,2023,10.15698/mic2023.12.809,https://pubmed.ncbi.nlm.nih.gov/38053573/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,27010853,Sodium-hydrogen exchanger NHA1 and NHA2 control sperm motility and male fertility.,2016,10.1038/cddis.2016.65,https://pubmed.ncbi.nlm.nih.gov/27010853/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,31208046,The Recretohalophyte Tamarix TrSOS1 Gene Confers Enhanced Salt Tolerance to Transgenic Hairy Root Composite Cotton Seedlings Exhibiting Virus-Induced Gene Silencing of GhSOS1.,2019,10.3390/ijms20122930,https://pubmed.ncbi.nlm.nih.gov/31208046/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,26113853,Quantitative description of ion transport via plasma membrane of yeast and small cells.,2015,10.3389/fpls.2015.00425,https://pubmed.ncbi.nlm.nih.gov/26113853/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,20438880,Analysis of a novel calcium auxotrophy in Aspergillus nidulans.,2010,10.1016/j.fgb.2010.04.002,https://pubmed.ncbi.nlm.nih.gov/20438880/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,18000046,A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension.,2007,10.1073/pnas.0707120104,https://pubmed.ncbi.nlm.nih.gov/18000046/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9B1,ENSG00000164037,Unsafe,16850186,Cloning of a novel human NHEDC1 (Na+/H+ exchanger like domain containing 1) gene expressed specifically in testis.,2006,10.1007/s11033-006-0010-y,https://pubmed.ncbi.nlm.nih.gov/16850186/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C1,ENSG00000172139,Unsafe,41091759,Formation of a complex between TMEM217 and the sodium-proton exchanger SLC9C1 is crucial for mouse sperm motility and male fertility.,2025,10.1073/pnas.2513924122,https://pubmed.ncbi.nlm.nih.gov/41091759/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C1,ENSG00000172139,Unsafe,37832806,Common as well as unique methylation-sensitive DNA regulatory elements in three mammalian SLC9C1 genes.,2024,10.1016/j.gene.2023.147897,https://pubmed.ncbi.nlm.nih.gov/37832806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C1,ENSG00000172139,Unsafe,39677330,Identification of differentially expressed genes in human testis biopsies with defective spermatogenesis.,2024,10.1002/rmb2.12616,https://pubmed.ncbi.nlm.nih.gov/39677330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C1,ENSG00000172139,Unsafe,36982403,The SLC9C2 Gene Product (Na+/H+ Exchanger Isoform 11; NHE11) Is a Testis-Specific Protein Localized to the Head of Mature Mammalian Sperm.,2023,10.3390/ijms24065329,https://pubmed.ncbi.nlm.nih.gov/36982403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C1,ENSG00000172139,Unsafe,37880360,Structure and electromechanical coupling of a voltage-gated Na&lt;sup&gt;+&lt;/sup&gt;/H&lt;sup&gt;+&lt;/sup&gt; exchanger.,2023,10.1038/s41586-023-06518-2,https://pubmed.ncbi.nlm.nih.gov/37880360/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C1,ENSG00000172139,Unsafe,39267058,Whole exome sequencing analysis of 167 men with primary infertility.,2024,10.1186/s12920-024-02005-3,https://pubmed.ncbi.nlm.nih.gov/39267058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C1,ENSG00000172139,Unsafe,40282371,Identification of Candidate Genes and Functional Pathways Associated with Body Size Traits in Hulunbuir Sheep Through GWAS Analysis.,2025,10.3390/genes16040410,https://pubmed.ncbi.nlm.nih.gov/40282371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C1,ENSG00000172139,Unsafe,39943155,"Resequencing Composite Kazakh Whiteheaded Cattle: Insights into Ancestral Breed Contributions, Selection Signatures, and Candidate Genetic Variants.",2025,10.3390/ani15030385,https://pubmed.ncbi.nlm.nih.gov/39943155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C1,ENSG00000172139,Unsafe,38702190,"Epigenome-wide association study of lung cancer among never smokers in two prospective cohorts in Shanghai, China.",2024,10.1136/thorax-2023-220352,https://pubmed.ncbi.nlm.nih.gov/38702190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C1,ENSG00000172139,Unsafe,37669933,Control of intracellular pH and bicarbonate by CO2 diffusion into human sperm.,2023,10.1038/s41467-023-40855-0,https://pubmed.ncbi.nlm.nih.gov/37669933/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C1,ENSG00000172139,Unsafe,37880361,Structures of a sperm-specific solute carrier gated by voltage and cAMP.,2023,10.1038/s41586-023-06629-w,https://pubmed.ncbi.nlm.nih.gov/37880361/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C1,ENSG00000172139,Unsafe,34810263,Molecular mechanisms of sperm motility are conserved in an early-branching metazoan.,2021,10.1073/pnas.2109993118,https://pubmed.ncbi.nlm.nih.gov/34810263/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C1,ENSG00000172139,Unsafe,30022052,The solute carrier SLC9C1 is a Na+/H+-exchanger gated by an S4-type voltage-sensor and cyclic-nucleotide binding.,2018,10.1038/s41467-018-05253-x,https://pubmed.ncbi.nlm.nih.gov/30022052/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C1,ENSG00000172139,Unsafe,34799600,Sperm preparedness and adaptation to osmotic and pH stressors relate to functional competence of sperm in Bos taurus.,2021,10.1038/s41598-021-01928-6,https://pubmed.ncbi.nlm.nih.gov/34799600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C1,ENSG00000172139,Unsafe,31664702,Familial Alzheimer's Disease and Recessive Modifiers.,2020,10.1007/s12035-019-01798-0,https://pubmed.ncbi.nlm.nih.gov/31664702/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C1,ENSG00000172139,Unsafe,33976808,Local environment-driven adaptive evolution in a marine invasive ascidian (Molgula manhattensis).,2021,10.1002/ece3.7322,https://pubmed.ncbi.nlm.nih.gov/33976808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C1,ENSG00000172139,Unsafe,21255775,A comprehensive gene mutation screen in men with asthenozoospermia.,2011,10.1016/j.fertnstert.2010.11.067,https://pubmed.ncbi.nlm.nih.gov/21255775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C1,ENSG00000172139,Unsafe,18931044,Can we generate new hypotheses about Dent's disease from gene analysis of a mouse model?,2009,10.1113/expphysiol.2008.044586,https://pubmed.ncbi.nlm.nih.gov/18931044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C2,ENSG00000162753,Unsafe,42103725,Chronic stress drives oligoasthenozoospermia via gut microbiota-vitamin-Sting1/Slc9c2 axis.,2026,10.1038/s41467-026-72450-4,https://pubmed.ncbi.nlm.nih.gov/42103725/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C2,ENSG00000162753,Unsafe,36982403,The SLC9C2 Gene Product (Na+/H+ Exchanger Isoform 11; NHE11) Is a Testis-Specific Protein Localized to the Head of Mature Mammalian Sperm.,2023,10.3390/ijms24065329,https://pubmed.ncbi.nlm.nih.gov/36982403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C2,ENSG00000162753,Unsafe,36297433,Cardiac Sodium/Hydrogen Exchanger (NHE11) as a Novel Potential Target for SGLT2i in Heart Failure: A Preliminary Study.,2022,10.3390/pharmaceutics14101996,https://pubmed.ncbi.nlm.nih.gov/36297433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C2,ENSG00000162753,Unsafe,38977582,Identifying key genes and functionally enriched pathways in acute myeloid leukemia by weighted gene co-expression network analysis.,2025,10.1007/s13353-024-00881-0,https://pubmed.ncbi.nlm.nih.gov/38977582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLC9C2,ENSG00000162753,Unsafe,30547318,Screening of Genetic Factor in the Interaction Between Periodontitis and Metabolic Traits Using Candidate Gene Association Study (CGAS).,2019,10.1007/s10528-018-9899-9,https://pubmed.ncbi.nlm.nih.gov/30547318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,41826328,Hepatocyte SLCO4C1 is a cAMP uptake transporter for inhibiting lipogenesis and a therapeutic target for MASLD.,2026,10.1038/s41467-026-70729-0,https://pubmed.ncbi.nlm.nih.gov/41826328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,40903846,Differential Expression Patterns of SLCO Solute Carriers in Human Breast Cancer Cell Lines and Tumour Samples.,2025,10.1111/jcmm.70838,https://pubmed.ncbi.nlm.nih.gov/40903846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,40600533,HFD-induced Alterations in Renal Tubular Oatp4c1-P-gp Transport Systems in Mice: Impact on Digoxin Renal Excretion and Gadolinium-Enhanced Radiological Manifestations.,2025,10.2174/0113892002371501250610074757,https://pubmed.ncbi.nlm.nih.gov/40600533/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,40474975,"Bupropion decreases plasma levels of asymmetric dimethylarginine and ameliorates renal injury by modulation of Ddah1, Oatp4c1, Oct2, and Mate1 in rats with adenine-induced chronic renal injury.",2025,10.3389/fphar.2025.1565713,https://pubmed.ncbi.nlm.nih.gov/40474975/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,40555835,Transport of the uremic toxin symmetric dimethylarginine (SDMA) by renal transport proteins.,2025,10.1007/s00726-025-03466-1,https://pubmed.ncbi.nlm.nih.gov/40555835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,39729035,Impaired renal transporter gene expression and uremic toxin excretion as aging hallmarks in cats with naturally occurring chronic kidney disease.,2024,10.18632/aging.206176,https://pubmed.ncbi.nlm.nih.gov/39729035/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,40148036,"Organic anion transporting polypeptides: Pharmacology, toxicology, structure, and transport mechanisms.",2025,10.1016/j.pharmr.2024.100023,https://pubmed.ncbi.nlm.nih.gov/40148036/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,38226966,Identification and validation of SLCO4C1 as a biological marker in hepatocellular carcinoma based on anoikis classification features.,2024,10.18632/aging.205438,https://pubmed.ncbi.nlm.nih.gov/38226966/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,42453346,Regulation of Renal Transporters by Pro-Inflammatory Cytokines in Human Proximal Tubular Epithelial Cells: Identification of the Perpetrator and Mechanisms.,2026,10.1021/acsptsci.6c00131,https://pubmed.ncbi.nlm.nih.gov/42453346/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,41898457,Preeclampsia Genomic Susceptibility Factors in Populations of African Ancestry: A Systematic Review and Meta-Analysis.,2026,10.3390/ijms27062594,https://pubmed.ncbi.nlm.nih.gov/41898457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,41398767,Systematic druggable genome-wide mendelian randomization identifies therapeutic targets for childhood asthma.,2025,10.1097/md.0000000000046718,https://pubmed.ncbi.nlm.nih.gov/41398767/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,33870862,Influence of vitamin D treatment on functional expression of drug disposition pathways in human kidney proximal tubule cells during simulated uremia.,2021,10.1080/00498254.2021.1909783,https://pubmed.ncbi.nlm.nih.gov/33870862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,38399338,Dysregulation of the mRNA Expression of Human Renal Drug Transporters by Proinflammatory Cytokines in Primary Human Proximal Tubular Epithelial Cells.,2024,10.3390/pharmaceutics16020285,https://pubmed.ncbi.nlm.nih.gov/38399338/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,38650001,T cell expressions of aberrant gene signatures and Co-inhibitory receptors (Co-IRs) as predictors of renal damage and lupus disease activity.,2024,10.1186/s12929-024-01024-7,https://pubmed.ncbi.nlm.nih.gov/38650001/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,38256064,The Use of an Antioxidant Enables Accurate Evaluation of the Interaction of Curcumin on Organic Anion-Transporting Polypeptides 4C1 by Preventing Auto-Oxidation.,2024,10.3390/ijms25020991,https://pubmed.ncbi.nlm.nih.gov/38256064/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,39014336,Identification of several lncRNA-mRNA pairs associated with marbling trait between Nanyang and Angus cattle.,2024,10.1186/s12864-024-10590-x,https://pubmed.ncbi.nlm.nih.gov/39014336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,38769028,Involvement of circRNA Regulators MBNL1 and QKI in the Progression of Esophageal Squamous Cell Carcinoma.,2024,10.1177/10732748241257142,https://pubmed.ncbi.nlm.nih.gov/38769028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,35955643,Bile Acid-Drug Interaction via Organic Anion-Transporting Polypeptide 4C1 Is a Potential Mechanism of Altered Pharmacokinetics of Renally Excreted Drugs.,2022,10.3390/ijms23158508,https://pubmed.ncbi.nlm.nih.gov/35955643/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,30865704,The renal transport protein OATP4C1 mediates uptake of the uremic toxin asymmetric dimethylarginine (ADMA) and efflux of cardioprotective L-homoarginine.,2019,10.1371/journal.pone.0213747,https://pubmed.ncbi.nlm.nih.gov/30865704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,39041788,Identification of a substrate of the renal tubular transporters for detecting drug-induced early acute kidney injury.,2024,10.1093/toxsci/kfae093,https://pubmed.ncbi.nlm.nih.gov/39041788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,36974330,Prognostic Lysosome-Related Biomarkers for Predicting Drug Candidates in Hepatocellular Carcinoma: An Insilco Analysis.,2023,10.2147/jhc.s401338,https://pubmed.ncbi.nlm.nih.gov/36974330/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,38817198,COVID-19 severity gradient differentially dysregulates clinically relevant drug processing genes in nasopharyngeal swab samples.,2024,10.1111/bcp.16124,https://pubmed.ncbi.nlm.nih.gov/38817198/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,34912216,"Drug Transporters in the Kidney: Perspectives on Species Differences, Disease Status, and Molecular Docking.",2021,10.3389/fphar.2021.746208,https://pubmed.ncbi.nlm.nih.gov/34912216/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,28057840,Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations.,2017,10.1124/jpet.116.237438,https://pubmed.ncbi.nlm.nih.gov/28057840/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,36365126,Construction and Evaluation of a Novel Organic Anion Transporter 1/3 CRISPR/Cas9 Double-Knockout Rat Model.,2022,10.3390/pharmaceutics14112307,https://pubmed.ncbi.nlm.nih.gov/36365126/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,35163972,The System Profile of Renal Drug Transporters in Tubulointerstitial Fibrosis Model and Consequent Effect on Pharmacokinetics.,2022,10.3390/molecules27030704,https://pubmed.ncbi.nlm.nih.gov/35163972/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,33033495,Weighted Gene Co-expression Network Analysis of Key Biomarkers Associated With Bronchopulmonary Dysplasia.,2020,10.3389/fgene.2020.539292,https://pubmed.ncbi.nlm.nih.gov/33033495/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,35720166,Evaluating the regulation of transporter proteins and P-glycoprotein in rats with cholestasis and its implication for digoxin clearance.,2022,10.4291/wjgp.v13.i3.73,https://pubmed.ncbi.nlm.nih.gov/35720166/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,31015435,Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease.,2019,10.1038/s41467-019-09735-4,https://pubmed.ncbi.nlm.nih.gov/31015435/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLCO4C1,ENSG00000173930,Unsafe,14993604,Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney.,2004,10.1073/pnas.0304987101,https://pubmed.ncbi.nlm.nih.gov/14993604/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,42135620,Identification and validation of serum SLIT1 as a biomarker for predicting anti-PD-1/PD-L1 resistance in non-small cell lung cancer.,2026,10.1186/s12575-026-00344-2,https://pubmed.ncbi.nlm.nih.gov/42135620/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,42277205,"S1UTRSP5, a short restructured RNA from SLIT1 3'UTR, mitigates mouse cardiac remodeling via enhancing SlRT1 activity.",2026,10.1038/s41401-026-01859-w,https://pubmed.ncbi.nlm.nih.gov/42277205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,41555045,Long-range chemical signalling in vivo is regulated by mechanical signals.,2026,10.1038/s41563-025-02463-9,https://pubmed.ncbi.nlm.nih.gov/41555045/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,42105438,A female-specific role for Slit1 in prenatal stress-induced depression vulnerability.,2026,10.1016/j.neurot.2026.e00916,https://pubmed.ncbi.nlm.nih.gov/42105438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,40996529,Redundant functions and mechanisms of action of Slit1 and Slit2 in ovarian granulosa cells.,2025,10.1530/rep-25-0210,https://pubmed.ncbi.nlm.nih.gov/40996529/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,40117292,A neuronal Slit1-dependent program rescues oligodendrocyte differentiation and myelination under chronic hypoxic conditions.,2025,10.1016/j.celrep.2025.115467,https://pubmed.ncbi.nlm.nih.gov/40117292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,39768930,Slit1 Promotes Hypertrophic Scar Formation Through the TGF-β Signaling Pathway.,2024,10.3390/medicina60122051,https://pubmed.ncbi.nlm.nih.gov/39768930/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,38943353,Slit1 inhibits ovarian follicle development and female fertility in mice†.,2024,10.1093/biolre/ioae106,https://pubmed.ncbi.nlm.nih.gov/38943353/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,41521561,SLIT2 as a key regulator and therapeutic target in liver injury.,2026,10.1016/j.ymthe.2026.01.010,https://pubmed.ncbi.nlm.nih.gov/41521561/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,41531492,Integrated bioinformatics analysis reveals Netrin-1 as a key molecular link between Parkinson's disease and heart failure.,2025,10.3389/fnagi.2025.1709337,https://pubmed.ncbi.nlm.nih.gov/41531492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,41029738,Exploration and validation of the immune-related genes signatures and potential molecular mechanisms shared between Alzheimer's disease (AD) and Parkinson's disease (PD).,2025,10.1186/s12920-025-02219-z,https://pubmed.ncbi.nlm.nih.gov/41029738/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,42716364,Gbx2 and Robo receptors control amacrine cell dendrite stratification in the mammalian retina.,2026,10.1016/j.ydbio.2026.09.003,https://pubmed.ncbi.nlm.nih.gov/42716364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,40806490,Direct and Indirect Downstream Pathways That Regulate Repulsive Guidance Effects of FGF3 on Developing Thalamocortical Axons.,2025,10.3390/ijms26157361,https://pubmed.ncbi.nlm.nih.gov/40806490/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,40868176,Identification of Candidate Genes for Endometriosis in a Three-Generation Family with Multiple Affected Members Using Whole-Exome Sequencing.,2025,10.3390/biomedicines13081922,https://pubmed.ncbi.nlm.nih.gov/40868176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,40508075,SLIT/ROBO Pathway and Prostate Cancer: Gene and Protein Expression and Their Prognostic Values.,2025,10.3390/ijms26115265,https://pubmed.ncbi.nlm.nih.gov/40508075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,35996510,Micro RNA-640 Targeting SLIT1 Enhances Glioma Radiosensitivity by Restraining the Activation of Wnt/β-Catenin Signaling Pathway.,2022,10.3389/bjbs.2022.10067,https://pubmed.ncbi.nlm.nih.gov/35996510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,40138590,Cancer-Associated Fibroblasts Foster a High-Lactate Microenvironment to Drive Perineural Invasion in Pancreatic Cancer.,2025,10.1158/0008-5472.can-24-3173,https://pubmed.ncbi.nlm.nih.gov/40138590/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,39863663,Evaluation of transcriptomic changes after photobiomodulation in spinal cord injury.,2025,10.1038/s41598-025-87300-4,https://pubmed.ncbi.nlm.nih.gov/39863663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,39159057,Multiple guidance mechanisms control axon growth to generate precise T-shaped bifurcation during dorsal funiculus development in the spinal cord.,2024,10.7554/elife.94109,https://pubmed.ncbi.nlm.nih.gov/39159057/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,37830982,SLIT3-mediated fibroblast signaling: a promising target for antifibrotic therapies.,2023,10.1152/ajpheart.00216.2023,https://pubmed.ncbi.nlm.nih.gov/37830982/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,36560848,Immune-related matrisomes are potential biomarkers to predict the prognosis and immune microenvironment of glioma patients.,2023,10.1002/2211-5463.13541,https://pubmed.ncbi.nlm.nih.gov/36560848/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,33552279,MicroRNA-640 promotes cell proliferation and adhesion in glioblastoma by targeting Slit guidance ligand 1.,2021,10.3892/ol.2020.12422,https://pubmed.ncbi.nlm.nih.gov/33552279/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,31607866,The ATP-P2X7 Signaling Pathway Participates in the Regulation of Slit1 Expression in Satellite Glial Cells.,2019,10.3389/fncel.2019.00420,https://pubmed.ncbi.nlm.nih.gov/31607866/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,26575696,The effects of house dust mite sublingual immunotherapy in patients with allergic rhinitis according to duration.,2016,10.1002/alr.21657,https://pubmed.ncbi.nlm.nih.gov/26575696/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,33526319,Long-term sublingual immunotherapy provides better effects for patients with Japanese cedar pollinosis.,2021,10.1016/j.anl.2021.01.003,https://pubmed.ncbi.nlm.nih.gov/33526319/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,29705951,Fibroblast growth factor receptor 1 signaling transcriptionally regulates the axon guidance cue slit1.,2018,10.1007/s00018-018-2824-x,https://pubmed.ncbi.nlm.nih.gov/29705951/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,35793981,Genetic Variants Associated with Supernormal Coronary Arteries.,2023,10.5551/jat.63554,https://pubmed.ncbi.nlm.nih.gov/35793981/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,31326446,"Toxicogenomic analyses of the effects of BDE-47/209, TBBPA/S and TCBPA on early neural development with a human embryonic stem cell in vitro differentiation system.",2019,10.1016/j.taap.2019.114685,https://pubmed.ncbi.nlm.nih.gov/31326446/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,33168897,Transcriptome and methylome analysis reveals three cellular origins of pituitary tumors.,2020,10.1038/s41598-020-76555-8,https://pubmed.ncbi.nlm.nih.gov/33168897/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,34305528,Spatial RNA Sequencing Identifies Robust Markers of Vulnerable and Resistant Human Midbrain Dopamine Neurons and Their Expression in Parkinson's Disease.,2021,10.3389/fnmol.2021.699562,https://pubmed.ncbi.nlm.nih.gov/34305528/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,30993182,The Expression of Key Guidance Genes at a Forebrain Axon Turning Point Is Maintained by Distinct Fgfr Isoforms but a Common Downstream Signal Transduction Mechanism.,2019,10.1523/eneuro.0086-19.2019,https://pubmed.ncbi.nlm.nih.gov/30993182/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,26899441,"Anti-depressant effects of Gastrodia elata Blume and its compounds gastrodin and 4-hydroxybenzyl alcohol, via the monoaminergic system and neuronal cytoskeletal remodeling.",2016,10.1016/j.jep.2016.02.001,https://pubmed.ncbi.nlm.nih.gov/26899441/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,25950486,Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells.,2015,10.1038/cddis.2015.121,https://pubmed.ncbi.nlm.nih.gov/25950486/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,25825206,Gene expression profiling of the hippocampal dentate gyrus in an adult toxicity study captures a variety of neurodevelopmental dysfunctions in rat models of hypothyroidism.,2016,10.1002/jat.3140,https://pubmed.ncbi.nlm.nih.gov/25825206/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,26225558,Genome-Wide Analyses Suggest Mechanisms Involving Early B-Cell Development in Canine IgA Deficiency.,2015,10.1371/journal.pone.0133844,https://pubmed.ncbi.nlm.nih.gov/26225558/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLIT1,ENSG00000187122,Unsafe,9813312,Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system.,1998,10.1016/s0169-328x(98)00224-1,https://pubmed.ncbi.nlm.nih.gov/9813312/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,42098304,SLX4IP limits replication stress globally and at ALT telomeres.,2026,10.1038/s44318-026-00790-4,https://pubmed.ncbi.nlm.nih.gov/42098304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,40383148,Loss of SLX4IP leads to common fragile site instability and compromises DNA interstrand crosslink repair in vivo.,2025,10.1016/j.jbc.2025.110244,https://pubmed.ncbi.nlm.nih.gov/40383148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,41402316,Molecular basis of XPF-ERCC1 targeting to SLX4-dependent DNA repair pathways.,2025,10.1038/s41467-025-67216-3,https://pubmed.ncbi.nlm.nih.gov/41402316/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,39488637,TGF-β superfamily-induced transcriptional activation pathways establish the RAD52-dependent ALT machinery during malignant transformation of MPNSTs.,2024,10.1038/s41598-024-76732-z,https://pubmed.ncbi.nlm.nih.gov/39488637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,34492133,SLX4IP N-terminus dictates telomeric localization in ALT-like castration-resistant prostate cancer cell lines.,2021,10.1002/pros.24225,https://pubmed.ncbi.nlm.nih.gov/34492133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,37890990,Alternative lengthening of telomeres: mechanism and the pathogenesis of cancer.,2024,10.1136/jcp-2023-209005,https://pubmed.ncbi.nlm.nih.gov/37890990/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,34187905,SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-κB and Notch signaling.,2021,10.1126/scisignal.abe9613,https://pubmed.ncbi.nlm.nih.gov/34187905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,33188147,SLX4IP Promotes Telomere Maintenance in Androgen Receptor-Independent Castration-Resistant Prostate Cancer through ALT-like Telomeric PML Localization.,2021,10.1158/1541-7786.mcr-20-0314,https://pubmed.ncbi.nlm.nih.gov/33188147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,31495888,SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair.,2019,10.1093/nar/gkz769,https://pubmed.ncbi.nlm.nih.gov/31495888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,32071280,SLX4IP and telomere dynamics dictate breast cancer metastasis and therapeutic responsiveness.,2020,10.26508/lsa.201900427,https://pubmed.ncbi.nlm.nih.gov/32071280/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,31447390,SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance.,2019,10.1016/j.molcel.2019.07.010,https://pubmed.ncbi.nlm.nih.gov/31447390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,31889939,Quantitative proteome analysis of Merkel cell carcinoma cell lines using SILAC.,2019,10.1186/s12014-019-9263-z,https://pubmed.ncbi.nlm.nih.gov/31889939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,33213082,Candidate Gene Markers Associated with Fecal Shedding of the Feline Enteric Coronavirus (FECV).,2020,10.3390/pathogens9110958,https://pubmed.ncbi.nlm.nih.gov/33213082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,34804132,Exploring the Structures and Functions of Macromolecular SLX4-Nuclease Complexes in Genome Stability.,2021,10.3389/fgene.2021.784167,https://pubmed.ncbi.nlm.nih.gov/34804132/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,33596761,Coordinated roles of SLX4 and MutSβ in DNA repair and the maintenance of genome stability.,2021,10.1080/10409238.2021.1881433,https://pubmed.ncbi.nlm.nih.gov/33596761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,31270560,Exploring the dark genome: implications for precision medicine.,2019,10.1007/s00335-019-09809-0,https://pubmed.ncbi.nlm.nih.gov/31270560/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,34205589,The Population Diversity of Candidate Genes for Resistance/Susceptibility to Coronavirus Infection in Domestic Cats: An Inter-Breed Comparison.,2021,10.3390/pathogens10060778,https://pubmed.ncbi.nlm.nih.gov/34205589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,30480765,Aneuploid acute myeloid leukemia exhibits a signature of genomic alterations in the cell cycle and protein degradation machinery.,2019,10.1002/cncr.31837,https://pubmed.ncbi.nlm.nih.gov/30480765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,31149201,NOVEL GENETIC FINDINGS IN A CHINESE FAMILY WITH EARLY-ONSET FEMALE-RELATED TYPE 2 DIABETES.,2017,10.4183/aeb.2017.364,https://pubmed.ncbi.nlm.nih.gov/31149201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,30979813,Functional CRISPR and shRNA Screens Identify Involvement of Mitochondrial Electron Transport in the Activation of Evofosfamide.,2019,10.1124/mol.118.115196,https://pubmed.ncbi.nlm.nih.gov/30979813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SLX4IP,ENSG00000149346,Unsafe,24045615,Frequent and sex-biased deletion of SLX4IP by illegitimate V(D)J-mediated recombination in childhood acute lymphoblastic leukemia.,2014,10.1093/hmg/ddt447,https://pubmed.ncbi.nlm.nih.gov/24045615/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,41904889,A Novel Nonsense Variant in TBX15 Transcription Factor Suggests an Expanded Genetic Spectrum Of Submucous Cleft Palate.,2026,10.1016/j.identj.2026.109520,https://pubmed.ncbi.nlm.nih.gov/41904889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,42555297,Three-Dimensional Evaluation of Pharynx in Patients With Different Severity Levels of Cleft Palate Using Cone-Beam Computed Tomography.,2026,10.1097/scs.0000000000013203,https://pubmed.ncbi.nlm.nih.gov/42555297/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,41665764,"Machine learning, whole-transcriptome and integrative omics analysis reveals key regulatory networks governing human spermatogonial stem cells.",2026,10.1007/s10238-026-02074-x,https://pubmed.ncbi.nlm.nih.gov/41665764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,42509736,High-Dimensional Immunophenotyping of Plasma-Derived Small Extracellular Vesicles in Pancreatic Cancer: An Exploratory Proof-of-Principle Study.,2026,10.3390/biom16070942,https://pubmed.ncbi.nlm.nih.gov/42509736/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,40379833,MCSP&lt;sup&gt;+&lt;/sup&gt; metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization.,2025,10.1038/s43018-025-00963-w,https://pubmed.ncbi.nlm.nih.gov/40379833/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,41166245,"Cross-cultural adaptation, reliability, and validity of the Turkish version of moral courage scale for physicians.",2025,10.1371/journal.pone.0333598,https://pubmed.ncbi.nlm.nih.gov/41166245/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,41385814,Congenital palatal fistula associated with submucous cleft palate: Surgical outcomes and insights from a case series of 27 patients.,2026,10.1016/j.bjps.2025.11.061,https://pubmed.ncbi.nlm.nih.gov/41385814/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,40821197,Management of Congenital Palatal Fistula Associated With Wiskott-Aldrich Syndrome.,2025,10.7759/cureus.88137,https://pubmed.ncbi.nlm.nih.gov/40821197/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,39220726,An organotypic human melanoma-in-skin model as an in vitro tool for testing Vγ9Vδ2-T cell-based immunotherapy.,2024,10.1016/j.iotech.2024.100724,https://pubmed.ncbi.nlm.nih.gov/39220726/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,42136066,Interfollicular Stem Cells of Human Epidermis Exhibit a Distinct Mechanical Signature That Deteriorates With Aging.,2026,10.1111/exd.70268,https://pubmed.ncbi.nlm.nih.gov/42136066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,41631021,Demography and Surgical Interventions of Submucous Cleft Palate: A Single-center Retrospective Case Series.,2026,10.53045/jprs.2024-0075,https://pubmed.ncbi.nlm.nih.gov/41631021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,41245767,Translation and Validation of the Chinese Version of Moral Courage Scale for Physicians.,2025,10.5334/pme.1896,https://pubmed.ncbi.nlm.nih.gov/41245767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,39733703,Multi-modal cross-domain self-supervised pre-training for fMRI and EEG fusion.,2025,10.1016/j.neunet.2024.107066,https://pubmed.ncbi.nlm.nih.gov/39733703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,40231574,Improvement of speech function in submucous cleft palate through conservative treatment.,2025,10.1111/cga.70009,https://pubmed.ncbi.nlm.nih.gov/40231574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,40885275,Techno-economic analysis of cost-competitive hard carbon production from biomass for sodium-ion batteries.,2025,10.1016/j.biortech.2025.133220,https://pubmed.ncbi.nlm.nih.gov/40885275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,41947835,Resonance Tube Therapy as a Novel Approach to Enhance Velopharyngeal Function.,2026,10.53045/jprs.2025-0006,https://pubmed.ncbi.nlm.nih.gov/41947835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,40403613,Stellate silicon microneedles for rapid point-of-care melanoma exosome isolation and detection via a lateral flow assay.,2025,10.1016/j.bios.2025.117560,https://pubmed.ncbi.nlm.nih.gov/40403613/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,37741800,A retrospective cephalometric study on the craniofacial morphology of adult patients with unoperated submucous cleft palate.,2023,10.1016/j.jcms.2023.08.005,https://pubmed.ncbi.nlm.nih.gov/37741800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,39152475,Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy.,2024,10.1186/s13024-024-00747-3,https://pubmed.ncbi.nlm.nih.gov/39152475/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,40723316,Polysaccharide Supplements from &lt;i&gt;Millettia speciosa Champ. ex Benth&lt;/i&gt; Enhance Growth and Meat Quality in Wenchang Chickens.,2025,10.3390/biology14070755,https://pubmed.ncbi.nlm.nih.gov/40723316/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,42225049,Cysteine protease as a novel serodiagnostic marker for Spirometra mansoni infection in cats.,2026,10.1016/j.vetpar.2026.110814,https://pubmed.ncbi.nlm.nih.gov/42225049/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,41586775,Analysis of the Chief Complaints at Consultation in 278 Patients With Submucous Cleft Palate.,2026,10.1097/scs.0000000000012476,https://pubmed.ncbi.nlm.nih.gov/41586775/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,42130402,Comparison of Speech Outcomes Following Furlow Z-Plasty Versus Pharyngeal Flap in the Primary Management of Submucous Cleft Palate.,2026,10.1177/10556656261445557,https://pubmed.ncbi.nlm.nih.gov/42130402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,40659004,Multi-Modal Cognitive Stimulation Program Improves Cognition and Quality of Life in Thai Older Adults with Mild Cognitive Impairment: A Randomized Controlled Trial.,2026,10.1159/000547310,https://pubmed.ncbi.nlm.nih.gov/40659004/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,37208128,Bispecific antibodies redirect synthetic agonistic receptor modified T cells against melanoma.,2023,10.1136/jitc-2022-006436,https://pubmed.ncbi.nlm.nih.gov/37208128/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,38709246,Gas-Amplified Metalloimmunotherapy with Dual Activation of Pyroptosis and the STING Pathway for Remodeling the Immunosuppressive Cervical Cancer Microenvironment.,2024,10.1021/acsnano.4c00017,https://pubmed.ncbi.nlm.nih.gov/38709246/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,40504044,Generation and functional analysis of melanoma antigen-specific CD8+ T cells derived from S/MAR vector-transfected human induced pluripotent stem cells.,2025,10.1002/ijc.35524,https://pubmed.ncbi.nlm.nih.gov/40504044/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,40062672,Longitudinal Speech Changes in Velopharyngeal Function in Submucous Cleft Palate.,2025,10.1002/ohn.1218,https://pubmed.ncbi.nlm.nih.gov/40062672/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,37221637,Outcomes of Primary Furlow Double-Opposing Z-plasty for the Treatment of Symptomatic Submucous Cleft Palate.,2023,10.1097/scs.0000000000009385,https://pubmed.ncbi.nlm.nih.gov/37221637/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,38468353,Social support and mental well-being among people with and without chronic illness during the Covid-19 pandemic: evidence from the longitudinal UCL covid survey.,2024,10.1186/s40359-024-01596-x,https://pubmed.ncbi.nlm.nih.gov/38468353/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,37579431,"The Evolution of External Healthcare Regulation in England; From Performance Oversight to Supporting Improvement Comment on ""The Special Measures for Quality and Challenged Provider Regimes in the English NHS: A Rapid Evaluation of a National Improvement Initiative for Failing Healthcare Organisations"".",2023,10.34172/ijhpm.2023.7809,https://pubmed.ncbi.nlm.nih.gov/37579431/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,35891187,Immunotherapeutic Targeting of NG2/CSPG4 in Solid Organ Cancers.,2022,10.3390/vaccines10071023,https://pubmed.ncbi.nlm.nih.gov/35891187/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,38681241,What Technique Results in the Lowest Rate of Velopharyngeal Insufficiency in Patients With Submucous Cleft Palate? A Systematic Review and Meta-Analysis.,2024,10.1177/22925503221110066,https://pubmed.ncbi.nlm.nih.gov/38681241/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,33951124,"Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study.",2021,10.15403/jgld-3401,https://pubmed.ncbi.nlm.nih.gov/33951124/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,35069706,Prediction of the RNA Tertiary Structure Based on a Random Sampling Strategy and Parallel Mechanism.,2021,10.3389/fgene.2021.813604,https://pubmed.ncbi.nlm.nih.gov/35069706/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,33441615,A chemokine-fusion vaccine targeting immature dendritic cells elicits elevated antibody responses to malaria sporozoites in infant macaques.,2021,10.1038/s41598-020-79427-3,https://pubmed.ncbi.nlm.nih.gov/33441615/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMCP,ENSG00000163206,Unsafe,8833144,"Isolation, expression, and chromosomal localization of the human mitochondrial capsule selenoprotein gene (MCSP).",1996,10.1006/geno.1996.0104,https://pubmed.ncbi.nlm.nih.gov/8833144/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMIM36,ENSG00000261873,Unsafe,41153404,A Genome-Wide Association Study in Psoriasis Patients Reveals Variants Associated with Response to Treatment with Interleukin-17A Pathway Inhibitors.,2025,10.3390/genes16101187,https://pubmed.ncbi.nlm.nih.gov/41153404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMKR1,ENSG00000240204,Unsafe,39512681,Exploring Pathogenic Genes in Frozen Shoulder through weighted gene co-expression network analysis and Mendelian Randomization.,2024,10.7150/ijms.98505,https://pubmed.ncbi.nlm.nih.gov/39512681/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SMKR1,ENSG00000240204,Unsafe,31959204,A DNA methylation signature to improve survival prediction of gastric cancer.,2020,10.1186/s13148-020-0807-x,https://pubmed.ncbi.nlm.nih.gov/31959204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,41195642,Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies.,2026,10.1002/acn3.70238,https://pubmed.ncbi.nlm.nih.gov/41195642/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,41310180,3D genetic architecture of schizophrenia risk across three neuronal subtypes.,2026,10.1038/s41380-025-03352-y,https://pubmed.ncbi.nlm.nih.gov/41310180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,42014657,Development of a metabolic subtype classifier for low-grade glioma to guide precision therapy.,2026,10.1007/s12672-026-04935-z,https://pubmed.ncbi.nlm.nih.gov/42014657/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,41162879,Proteomic signature of aging in bloodstain samples: a preliminary study.,2025,10.1186/s12864-025-12164-x,https://pubmed.ncbi.nlm.nih.gov/41162879/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,39163863,Physical exercise mediates cortical synaptic protein lactylation to improve stress resilience.,2024,10.1016/j.cmet.2024.07.018,https://pubmed.ncbi.nlm.nih.gov/39163863/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,38098057,Beyond the exome: utility of long-read whole genome sequencing in exome-negative autosomal recessive diseases.,2023,10.1186/s13073-023-01270-8,https://pubmed.ncbi.nlm.nih.gov/38098057/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,39753749,Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia.,2025,10.1038/s41562-024-02091-4,https://pubmed.ncbi.nlm.nih.gov/39753749/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,38990251,Synaptic Vesicle-Related Proteins and Ubiquilin 2 in Cortical Synaptosomes Mediate Cognitive Impairment in Vascular Dementia Rats.,2025,10.1007/s12035-024-04327-w,https://pubmed.ncbi.nlm.nih.gov/38990251/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,37784143,An alpha-helix variant p.Arg156Pro in LMNA as a cause of hereditary dilated cardiomyopathy: genetics and bioinfomatics exploration.,2023,10.1186/s12920-023-01661-1,https://pubmed.ncbi.nlm.nih.gov/37784143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,33356818,Clinical significance and potential molecular mechanism of miRNA-222-3p in metastatic prostate cancer.,2021,10.1080/21655979.2020.1867405,https://pubmed.ncbi.nlm.nih.gov/33356818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,33858496,Identification of DNA methylation markers for early detection of CRC indicates a role for nervous system-related genes in CRC.,2021,10.1186/s13148-021-01067-9,https://pubmed.ncbi.nlm.nih.gov/33858496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,34880896,Circular RNA Expression and Regulation Profiling in Testicular Tissues of Immature and Mature Wandong Cattle (Bos taurus).,2021,10.3389/fgene.2021.685541,https://pubmed.ncbi.nlm.nih.gov/34880896/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,38073751,Analysis of a Four-Component Competing Endogenous RNA Network Reveals Potential Biomarkers in Gastric Cancer: An Integrated Systems Biology and Experimental Investigation.,2023,10.4103/abr.abr_185_23,https://pubmed.ncbi.nlm.nih.gov/38073751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,35203526,A Novel 16-Genes Signature Scoring System as Prognostic Model to Evaluate Survival Risk in Patients with Glioblastoma.,2022,10.3390/biomedicines10020317,https://pubmed.ncbi.nlm.nih.gov/35203526/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,36028080,Perfluorooctanoic acid-induced developmental cardiotoxicity in chicken embryo: Roles of miR-490-5p.,2022,10.1016/j.envpol.2022.120022,https://pubmed.ncbi.nlm.nih.gov/36028080/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,33324198,Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer's Disease Pathogenesis.,2020,10.3389/fnagi.2020.605961,https://pubmed.ncbi.nlm.nih.gov/33324198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,31929350,MicroRNA-301b and its target gene synaptosome-associated protein 91 as important modulators in esophageal cancer: functional experiments.,2020,10.1097/cad.0000000000000893,https://pubmed.ncbi.nlm.nih.gov/31929350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,27655637,COL3A1 and SNAP91: novel glioblastoma markers with diagnostic and prognostic value.,2016,10.18632/oncotarget.12038,https://pubmed.ncbi.nlm.nih.gov/27655637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,34151536,Analysis of high-risk pedigrees identifies 11 candidate variants for Alzheimer's disease.,2022,10.1002/alz.12397,https://pubmed.ncbi.nlm.nih.gov/34151536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,34211824,Identification of a Seven-lncRNA-mRNA Signature for Recurrence and Prognostic Prediction in Relapsed Acute Lymphoblastic Leukemia Based on WGCNA and LASSO Analyses.,2021,10.1155/2021/6692022,https://pubmed.ncbi.nlm.nih.gov/34211824/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,36000950,Diverse mutations and structural variations contribute to Notch signaling deregulation in paediatric T-cell lymphoblastic lymphoma.,2022,10.1002/pbc.29926,https://pubmed.ncbi.nlm.nih.gov/36000950/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAP91,ENSG00000065609,Unsafe,26945057,"Dynamic internalization and recycling of a metal ion transporter: Cu homeostasis and CTR1, the human Cu⁺ uptake system.",2016,10.1242/jcs.173351,https://pubmed.ncbi.nlm.nih.gov/26945057/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,41006818,Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci.,2025,10.1038/s41366-025-01898-z,https://pubmed.ncbi.nlm.nih.gov/41006818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,40956881,SUMO conjugation to promoter-proximal sequence elements-associated proteins impacts on snRNA transcription.,2025,10.1073/pnas.2417409122,https://pubmed.ncbi.nlm.nih.gov/40956881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,40706988,"A Systematic, Evidence-Based Workflow for Classifying KMT2A Fusions in Acute Myeloid Leukemia.",2025,10.1016/j.jmoldx.2025.06.007,https://pubmed.ncbi.nlm.nih.gov/40706988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,36369505,Structural basis of human SNAPc recognizing proximal sequence element of snRNA promoter.,2022,10.1038/s41467-022-34639-1,https://pubmed.ncbi.nlm.nih.gov/36369505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,34922489,Profiles of immune cell infiltration and immune-related genes in the tumor microenvironment of osteosarcoma cancer.,2021,10.1186/s12885-021-09042-6,https://pubmed.ncbi.nlm.nih.gov/34922489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,34108018,TBP and SNAP50 transcription factors bind specifically to the Pr77 promoter sequence from trypanosomatid non-LTR retrotransposons.,2021,10.1186/s13071-021-04803-5,https://pubmed.ncbi.nlm.nih.gov/34108018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,34937578,DNA methylation mediates the association between breastfeeding and early-life growth trajectories.,2021,10.1186/s13148-021-01209-z,https://pubmed.ncbi.nlm.nih.gov/34937578/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,31646075,"Expression of MHC class I, HLA-A and HLA-B identifies immune-activated breast tumors with favorable outcome.",2019,10.1080/2162402x.2019.1629780,https://pubmed.ncbi.nlm.nih.gov/31646075/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,25581648,Dual-trait selection for ethanol consumption and withdrawal: genetic and transcriptional network effects.,2014,10.1111/acer.12574,https://pubmed.ncbi.nlm.nih.gov/25581648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,19356248,Histone acetylations mark origins of polycistronic transcription in Leishmania major.,2009,10.1186/1471-2164-10-152,https://pubmed.ncbi.nlm.nih.gov/19356248/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,23646176,Genomic analysis of sequence-dependent DNA curvature in Leishmania.,2013,10.1371/journal.pone.0063068,https://pubmed.ncbi.nlm.nih.gov/23646176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,16603380,Co-expression of multiple subunits enables recombinant SNAPC assembly and function for transcription by human RNA polymerases II and III.,2006,10.1016/j.pep.2006.02.015,https://pubmed.ncbi.nlm.nih.gov/16603380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,14733910,Molecular hierarchy in neurons differentiated from mouse ES cells containing a single human chromosome 21.,2004,10.1016/j.bbrc.2003.12.091,https://pubmed.ncbi.nlm.nih.gov/14733910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,9003788,"Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc.",1996,10.1002/j.1460-2075.1996.tb01104.x,https://pubmed.ncbi.nlm.nih.gov/9003788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,16098103,Involvement of SRD2-mediated activation of snRNA transcription in the control of cell proliferation competence in Arabidopsis.,2005,10.1111/j.1365-313x.2005.02469.x,https://pubmed.ncbi.nlm.nih.gov/16098103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,14757834,The Trypanosoma brucei spliced leader RNA and rRNA gene promoters have interchangeable TbSNAP50-binding elements.,2004,10.1093/nar/gkh231,https://pubmed.ncbi.nlm.nih.gov/14757834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,12391172,Redundant cooperative interactions for assembly of a human U6 transcription initiation complex.,2002,10.1128/mcb.22.22.8067-8078.2002,https://pubmed.ncbi.nlm.nih.gov/12391172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,9732265,SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III.,1998,10.1101/gad.12.17.2664,https://pubmed.ncbi.nlm.nih.gov/9732265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,11094070,The retinoblastoma tumor suppressor protein targets distinct general transcription factors to regulate RNA polymerase III gene expression.,2000,10.1128/mcb.20.24.9182-9191.2000,https://pubmed.ncbi.nlm.nih.gov/11094070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC3,ENSG00000164975,Unsafe,9418884,The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1.,1998,10.1128/mcb.18.1.368,https://pubmed.ncbi.nlm.nih.gov/9418884/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC5,ENSG00000174446,Unsafe,38312596,Long noncoding RNA lnc-SNAPC5-3:4 inhibits malignancy by directly upregulating miR-224-3p in non-small cell lung cancer.,2024,10.1016/j.heliyon.2024.e24668,https://pubmed.ncbi.nlm.nih.gov/38312596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC5,ENSG00000174446,Unsafe,39833228,Brain gliomas new transcriptomic discoveries from differentially expressed genes to therapeutic targets.,2025,10.1038/s41598-025-86316-0,https://pubmed.ncbi.nlm.nih.gov/39833228/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC5,ENSG00000174446,Unsafe,39747245,Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters.,2025,10.1038/s41467-024-55553-8,https://pubmed.ncbi.nlm.nih.gov/39747245/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC5,ENSG00000174446,Unsafe,37441804,"Exploring Cancer Dependency Map genes and immune subtypes in colon cancer, in which TIGD1 contributes to colon cancer progression.",2023,10.18632/aging.204859,https://pubmed.ncbi.nlm.nih.gov/37441804/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC5,ENSG00000174446,Unsafe,35672525,The role of plasma exosomal lnc-SNAPC5-3:4 in monitoring the efficacy of anlotinib in the treatment of advanced non-small cell lung cancer.,2022,10.1007/s00432-022-04071-5,https://pubmed.ncbi.nlm.nih.gov/35672525/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC5,ENSG00000174446,Unsafe,16603380,Co-expression of multiple subunits enables recombinant SNAPC assembly and function for transcription by human RNA polymerases II and III.,2006,10.1016/j.pep.2006.02.015,https://pubmed.ncbi.nlm.nih.gov/16603380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC5,ENSG00000174446,Unsafe,9732265,SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III.,1998,10.1101/gad.12.17.2664,https://pubmed.ncbi.nlm.nih.gov/9732265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNAPC5,ENSG00000174446,Unsafe,12391172,Redundant cooperative interactions for assembly of a human U6 transcription initiation complex.,2002,10.1128/mcb.22.22.8067-8078.2002,https://pubmed.ncbi.nlm.nih.gov/12391172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42643333,AHCSIS: adaptive evaluation model for stereoscopic visual comfort based on HHT-CSP-SSA and improved SNN.,2026,10.3389/fnins.2026.1839200,https://pubmed.ncbi.nlm.nih.gov/42643333/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42403478,Adaptive memristor-based LIF neuron circuit for energy efficient SNN crossbar array.,2026,10.1007/s11571-026-10493-5,https://pubmed.ncbi.nlm.nih.gov/42403478/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42590654,SAD-SNN: Spatial-Activation Distillation for High-Performance Spiking Neural Networks.,2026,10.3390/s26154877,https://pubmed.ncbi.nlm.nih.gov/42590654/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42505514,Task-State fMRI-Derived Whole-Brain Functional Topology-Constrained Spiking Neural Network with an Embedded Auditory Core Circuit for Speech Recognition.,2026,10.3390/biomimetics11070481,https://pubmed.ncbi.nlm.nih.gov/42505514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,41144417,SNN-FT: Temporal-Coded Spiking Neural Networks for Fourier Transform.,2026,10.1109/tnnls.2025.3622893,https://pubmed.ncbi.nlm.nih.gov/41144417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42284823,SD&lt;sup&gt;2&lt;/sup&gt;-SNN: Self-distillation and structural decomposition framework for SNNs in continual learning.,2026,10.1016/j.neunet.2026.109241,https://pubmed.ncbi.nlm.nih.gov/42284823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42781073,SPiKe-Med: a hybrid spiking-CNN-transformer framework for energy-efficient brain tumor MRI segmentation.,2026,10.3389/frai.2026.1852940,https://pubmed.ncbi.nlm.nih.gov/42781073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42224325,DBHN-Net: Dual-Branch Hybrid Neural Network for Low-Complexity Monaural Speech Enhancement.,2026,10.1109/tpami.2026.3698087,https://pubmed.ncbi.nlm.nih.gov/42224325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42371896,ANP-R: A 22nm 0.88pJ/SOP Asynchronous SNN-based Processor with Coarse-Grained Reconfigurable Architecture Enabling Multisensory On-chip Incremental Learning for Edge AI.,2026,10.1109/tbcas.2026.3708212,https://pubmed.ncbi.nlm.nih.gov/42371896/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42780973,Multi-plasticity synergy with adaptive mechanism assignment for training spiking neural networks.,2026,10.3389/fnins.2026.1939650,https://pubmed.ncbi.nlm.nih.gov/42780973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,41779837,The 3D architecture of the ctenophore aboral organ and the evolution of complex integrative centers in animals.,2026,10.1126/sciadv.aea8399,https://pubmed.ncbi.nlm.nih.gov/41779837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42590470,"DCPA-SNN, Direct-Coding-Physics-Aware Spiking Neural Network: A Framework for Wearable ECG Denoising Under Dynamic-Noise Conditions.",2026,10.3390/s26154695,https://pubmed.ncbi.nlm.nih.gov/42590470/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,41435729,NSPDI-SNN: An efficient lightweight SNN based on nonlinear synaptic pruning and dendritic integration.,2026,10.1016/j.neunet.2025.108417,https://pubmed.ncbi.nlm.nih.gov/41435729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,41892131,"eXCube2: Explainable Brain-Inspired Spiking Neural Network Framework for Emotion Recognition from Audio, Visual and Multimodal Audio-Visual Data.",2026,10.3390/biomimetics11030208,https://pubmed.ncbi.nlm.nih.gov/41892131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42055332,Insights into the role of internal catalysts in asparagine-to-succinimide conversion in a hyperthermophilic glutamine amidotransferase.,2026,10.1016/j.jbc.2026.113093,https://pubmed.ncbi.nlm.nih.gov/42055332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42324274,Performance evaluation of AkidaNet converted to spiking domain for the classification of weeds in cotton fields.,2026,10.1038/s41598-026-54153-4,https://pubmed.ncbi.nlm.nih.gov/42324274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42122581,UDC-SNN: An Uncertainty-Aware Dynamic Cascading Framework with Spiking Neural Network for Balancing Performance and Energy in Multimodal Emotion Recognition.,2026,10.3390/s26092859,https://pubmed.ncbi.nlm.nih.gov/42122581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42041830,Event-Based Vision at the Edge: A Review.,2026,10.3390/brainsci16040422,https://pubmed.ncbi.nlm.nih.gov/42041830/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42255354,CrossModal-associated-SNN: multi-channel spiking neural networks with clustering and associative learning.,2026,10.1007/s11571-026-10487-3,https://pubmed.ncbi.nlm.nih.gov/42255354/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42187369,Speech Recognition with an fMRISNN Constrained by Human Functional Brain Networks: A Study of Enhanced MFCC-Driven Sparse Spike Encoding.,2026,10.3390/biomimetics11050302,https://pubmed.ncbi.nlm.nih.gov/42187369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42885404,"Correction: Rathee et al. SIFT-SNN for Traffic-Flow Infrastructure Safety: A Real-Time Context-Aware Anomaly Detection Framework. &lt;i&gt;J. Imaging&lt;/i&gt; 2026, &lt;i&gt;12&lt;/i&gt;, 64.",2026,10.3390/jimaging12100467,https://pubmed.ncbi.nlm.nih.gov/42885404/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42898395,Improving performance in SNN-based deep reinforcement learning via transition-aware embeddings.,2026,10.3389/fnbot.2026.1929177,https://pubmed.ncbi.nlm.nih.gov/42898395/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42168468,"Energy-efficient, real-time detection of railway fastening systems from drone-based imagery using spiking neural networks.",2026,10.1038/s41598-026-53237-5,https://pubmed.ncbi.nlm.nih.gov/42168468/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42656600,The role of inhibition in modeling decision making with spiking neural networks.,2026,10.3389/fninf.2026.1854811,https://pubmed.ncbi.nlm.nih.gov/42656600/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,40510120,Random heterogeneous spiking neural network for adversarial defense.,2025,10.1016/j.isci.2025.112660,https://pubmed.ncbi.nlm.nih.gov/40510120/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,39799207,Obtaining personalized predictions from a randomized controlled trial on Alzheimer's disease.,2025,10.1038/s41598-024-84687-4,https://pubmed.ncbi.nlm.nih.gov/39799207/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,39344260,"Sensory Neuronopathies: Clinical Presentation, Management, and Outcome.",2024,10.4103/aian.aian_303_24,https://pubmed.ncbi.nlm.nih.gov/39344260/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,41462047,Neuromorphic robust framework for integrated estimation and control in dynamical systems using spiking neural networks.,2025,10.1038/s41598-025-28344-4,https://pubmed.ncbi.nlm.nih.gov/41462047/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,41716657,Bidirectional cross-day alignment of neural spikes and behavior using a hybrid SNN-ANN algorithm.,2026,10.3389/fnins.2026.1772958,https://pubmed.ncbi.nlm.nih.gov/41716657/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,42197858,Neuromorphic Technologies for Neuroengineering: From Adaptive Stimulation to SNN-Based Inference and Deployable Biointerfaces.,2026,10.3390/s26103049,https://pubmed.ncbi.nlm.nih.gov/42197858/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,41600482,Impact Analysis of the Market Penetration Rate of Connected Vehicles and the Failure Rate of Roadside Equipment on Data Accuracy.,2026,10.3390/s26020686,https://pubmed.ncbi.nlm.nih.gov/41600482/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,41134528,A multifunctional probe for optical and electrochemical detection of hydrogen sulfide and real-time selective fungal imaging.,2025,10.1039/d5an00783f,https://pubmed.ncbi.nlm.nih.gov/41134528/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,41079560,Learning and inference with correlated neural variability.,2025,10.1093/pnasnexus/pgaf284,https://pubmed.ncbi.nlm.nih.gov/41079560/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,41286087,Trend Factor Smoothing and Tasmanian Devil Optimization based Siamese Neural Network for anomaly detection in predictive maintenance.,2025,10.1038/s41598-025-25312-w,https://pubmed.ncbi.nlm.nih.gov/41286087/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,41745429,SIFT-SNN for Traffic-Flow Infrastructure Safety: A Real-Time Context-Aware Anomaly Detection Framework.,2026,10.3390/jimaging12020064,https://pubmed.ncbi.nlm.nih.gov/41745429/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,39085549,Feasibility of Regional Lymphadenectomy for Stomach-Preserving Surgery in Early Gastric Cancer Omitting Sentinel Node Navigation: A Post Hoc Analysis of the SENORITA Trial.,2024,10.1245/s10434-024-15950-1,https://pubmed.ncbi.nlm.nih.gov/39085549/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,41414245,Real-time vibration mode recognition of &lt;i&gt;φ&lt;/i&gt;-OTDR based on Opus audio compression and spiking neural networks.,2025,10.1364/oe.578219,https://pubmed.ncbi.nlm.nih.gov/41414245/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNN,ENSG00000184602,Unsafe,41261120,Neuromorphic computing paradigms enhance robustness through spiking neural networks.,2025,10.1038/s41467-025-65197-x,https://pubmed.ncbi.nlm.nih.gov/41261120/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,41318855,SNX16 aggravates AngII-induced cardiac hypertrophy in mice via EGFR transactivation.,2025,10.1038/s42003-025-09243-w,https://pubmed.ncbi.nlm.nih.gov/41318855/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,41237209,mTORC1 regulates autophagosomal components recycling through SNX16 phosphorylation.,2025,10.1073/pnas.2511069122,https://pubmed.ncbi.nlm.nih.gov/41237209/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,41747779,TAS2R46 activation protects intestinal barrier from chronic high glucose.,2026,10.1016/j.bbi.2026.106516,https://pubmed.ncbi.nlm.nih.gov/41747779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,38849490,SNX16 is required for hepatocellular carcinoma survival via modulating the EGFR-AKT signaling pathway.,2024,10.1038/s41598-024-64015-6,https://pubmed.ncbi.nlm.nih.gov/38849490/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,35482720,Comprehensive analysis of GSEC/miR-101-3p/SNX16/PAPOLG axis in hepatocellular carcinoma.,2022,10.1371/journal.pone.0267117,https://pubmed.ncbi.nlm.nih.gov/35482720/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,35458555,A Single Amino Acid Residue R144 of SNX16 Affects Its Ability to Inhibit the Replication of Influenza A Virus.,2022,10.3390/v14040825,https://pubmed.ncbi.nlm.nih.gov/35458555/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,31876369,SNX16 activates c-Myc signaling by inhibiting ubiquitin-mediated proteasomal degradation of eEF1A2 in colorectal cancer development.,2020,10.1002/1878-0261.12626,https://pubmed.ncbi.nlm.nih.gov/31876369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,32579212,BHLHE40 plays a pathological role in pre-eclampsia through upregulating SNX16 by transcriptional inhibition of miR-196a-5p.,2020,10.1093/molehr/gaaa037,https://pubmed.ncbi.nlm.nih.gov/32579212/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,34633594,Differential Expression of LOXL1-AS1 in Coronary Heart Disease and its Regulatory Mechanism in ox-LDL-Induced Human Coronary Artery Endothelial Cell Pyroptosis.,2023,10.1007/s10557-021-07274-z,https://pubmed.ncbi.nlm.nih.gov/34633594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,32012743,Circulating Anti-Sorting Nexins 16 Antibodies as an Emerging Biomarker of Coronary Artery Disease in Patients with Obstructive Sleep Apnea.,2020,10.3390/diagnostics10020071,https://pubmed.ncbi.nlm.nih.gov/32012743/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,31253649,Higher-order assembly of Sorting Nexin 16 controls tubulation and distribution of neuronal endosomes.,2019,10.1083/jcb.201811074,https://pubmed.ncbi.nlm.nih.gov/31253649/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,35575181,Myosin V facilitates polarised E-cadherin secretion.,2022,10.1111/tra.12846,https://pubmed.ncbi.nlm.nih.gov/35575181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,25408875,SNX16 negatively regulates the migration and tumorigenesis of MCF-7 cells.,2013,10.1186/2045-9769-2-3,https://pubmed.ncbi.nlm.nih.gov/25408875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,21754999,Role of SNX16 in the dynamics of tubulo-cisternal membrane domains of late endosomes.,2011,10.1371/journal.pone.0021771,https://pubmed.ncbi.nlm.nih.gov/21754999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,21464232,A presynaptic endosomal trafficking pathway controls synaptic growth signaling.,2011,10.1083/jcb.201009052,https://pubmed.ncbi.nlm.nih.gov/21464232/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,24345872,ChIP-seq analysis of histone H3K9 trimethylation in peripheral blood mononuclear cells of membranous nephropathy patients.,2014,10.1590/1414-431x20132809,https://pubmed.ncbi.nlm.nih.gov/24345872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,19754948,Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study.,2009,10.1186/1471-2350-10-91,https://pubmed.ncbi.nlm.nih.gov/19754948/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,15292396,Sorting nexin 16 regulates EGF receptor trafficking by phosphatidylinositol-3-phosphate interaction with the Phox domain.,2004,10.1242/jcs.01233,https://pubmed.ncbi.nlm.nih.gov/15292396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,12813048,Evidence for a role of SNX16 in regulating traffic between the early and later endosomal compartments.,2003,10.1074/jbc.m300143200,https://pubmed.ncbi.nlm.nih.gov/12813048/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX16,ENSG00000104497,Unsafe,15951806,Endosome-to-cytosol transport of viral nucleocapsids.,2005,10.1038/ncb1269,https://pubmed.ncbi.nlm.nih.gov/15951806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,41863598,Schizophrenia risk variants modulate transcription factor binding and gene expression in cortical cell types.,2026,10.1007/s00018-026-06177-2,https://pubmed.ncbi.nlm.nih.gov/41863598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,40002894,SNX19 Interacts with Caveolin-1 and Flotillin-1 to Regulate D1R Endocytosis and Signaling.,2025,10.3390/biomedicines13020481,https://pubmed.ncbi.nlm.nih.gov/40002894/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,40136427,Exploring the Therapeutic Potential of the DOT1L Inhibitor EPZ004777 Using Bioinformatics and Molecular Docking Approaches in Acute Myeloid Leukemia.,2025,10.3390/cimb47030173,https://pubmed.ncbi.nlm.nih.gov/40136427/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,33649454,Single molecule in situ hybridization reveals distinct localizations of schizophrenia risk-related transcripts SNX19 and AS3MT in human brain.,2021,10.1038/s41380-021-01046-9,https://pubmed.ncbi.nlm.nih.gov/33649454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,37794117,Whole-genome sequencing analysis of suicide deaths integrating brain-regulatory eQTLs data to identify risk loci and genes.,2023,10.1038/s41380-023-02282-x,https://pubmed.ncbi.nlm.nih.gov/37794117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,38549512,Mendelian randomization analysis using GWAS and eQTL data to investigate the relationship between chronotype and neuropsychiatric disorders and their molecular basis.,2024,10.1002/ajmg.b.32980,https://pubmed.ncbi.nlm.nih.gov/38549512/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,36324508,Genetic architecture and selection of Anhui autochthonous pig population revealed by whole genome resequencing.,2022,10.3389/fgene.2022.1022261,https://pubmed.ncbi.nlm.nih.gov/36324508/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,34315878,SNX19 restricts endolysosome motility through contacts with the endoplasmic reticulum.,2021,10.1038/s41467-021-24709-1,https://pubmed.ncbi.nlm.nih.gov/34315878/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,39334355,Longitudinal association of peripheral blood DNA methylation with liver fat content: distinguishing between predictors and biomarkers.,2024,10.1186/s12944-024-02304-9,https://pubmed.ncbi.nlm.nih.gov/39334355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,32259353,Lipid rafts are required for effective renal D1 dopamine receptor function.,2020,10.1096/fj.201902710rr,https://pubmed.ncbi.nlm.nih.gov/32259353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,36341443,Case report: ETS1 gene deletion associated with a low number of recent thymic emigrants in three patients with Jacobsen syndrome.,2022,10.3389/fimmu.2022.867206,https://pubmed.ncbi.nlm.nih.gov/36341443/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,30635639,Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19).,2020,10.1038/s41380-018-0293-0,https://pubmed.ncbi.nlm.nih.gov/30635639/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,33652569,SNX-PXA-RGS-PXC Subfamily of SNXs in the Regulation of Receptor-Mediated Signaling and Membrane Trafficking.,2021,10.3390/ijms22052319,https://pubmed.ncbi.nlm.nih.gov/33652569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,39132059,DNA Methylation in Noncancerous Liver Tissues as Biomarker for Multicentric Occurrence of Hepatitis C Virus-Related Hepatocellular Carcinoma.,2022,10.1016/j.gastha.2022.02.016,https://pubmed.ncbi.nlm.nih.gov/39132059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,32047265,Variations and expression features of CYP2D6 contribute to schizophrenia risk.,2021,10.1038/s41380-020-0675-y,https://pubmed.ncbi.nlm.nih.gov/32047265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,28335009,Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci.,2017,10.1093/hmg/ddx103,https://pubmed.ncbi.nlm.nih.gov/28335009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,33050709,Genetic determinants of ammonia-induced acute lung injury in mice.,2021,10.1152/ajplung.00276.2020,https://pubmed.ncbi.nlm.nih.gov/33050709/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,28552197,Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression.,2017,10.1016/j.ajhg.2017.04.016,https://pubmed.ncbi.nlm.nih.gov/28552197/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,31425724,Integrating genome-wide association study and methylation functional annotation data identified candidate genes and pathways for schizophrenia.,2020,10.1016/j.pnpbp.2019.109736,https://pubmed.ncbi.nlm.nih.gov/31425724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,25148684,Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling.,2014,10.1074/jbc.m114.595959,https://pubmed.ncbi.nlm.nih.gov/25148684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SNX19,ENSG00000120451,Unsafe,34335698,Epigenetic Markers Are Associated With Differences in Isocyanate Biomarker Levels in Exposed Spray-Painters.,2021,10.3389/fgene.2021.700636,https://pubmed.ncbi.nlm.nih.gov/34335698/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,40418209,Sohlh1 Modulates the Stemness and Differentiation of Glioma Stem-Like Cells by Inactivation of Wnt/β-Catenin Signalling Pathway via SFRP1.,2025,10.1111/jcmm.70599,https://pubmed.ncbi.nlm.nih.gov/40418209/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,41981464,The transcription factor E4F1 is crucial for spermatogonial differentiation and meiosis progression in mice.,2026,10.1186/s12864-026-12649-3,https://pubmed.ncbi.nlm.nih.gov/41981464/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,41429626,[Polyphyllin VII inhibits osteosarcoma xenograft growth in mice by inducing ferroptosis via upregulating SOHLH1].,2025,10.12122/j.issn.1673-4254.2025.12.20,https://pubmed.ncbi.nlm.nih.gov/41429626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,39952345,Effect of vitrification on in vitro developmental competence of rat testicular tissue.,2025,10.1016/j.cryobiol.2025.105213,https://pubmed.ncbi.nlm.nih.gov/39952345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,36723967,Sohlh1 loss of function male and female infertility model impacts overall health beyond gonadal dysfunction in mice†.,2023,10.1093/biolre/ioad008,https://pubmed.ncbi.nlm.nih.gov/36723967/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,39950040,Clinical phenotype and genetic analysis of patients with severe oligoasthenospermia carrying heterozygous SOHLH1 c.346-1G>A mutation.,2025,10.3389/fgene.2025.1531697,https://pubmed.ncbi.nlm.nih.gov/39950040/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,39210919,Prochloraz induced alterations in the expression of mRNA in the reproductive system of male offspring mice.,2024,10.7717/peerj.17917,https://pubmed.ncbi.nlm.nih.gov/39210919/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,34448846,The mutation c.346-1G > A in SOHLH1 impairs sperm production in the homozygous but not in the heterozygous condition.,2022,10.1093/hmg/ddab242,https://pubmed.ncbi.nlm.nih.gov/34448846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,37194006,Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice.,2023,10.1186/s12958-023-01097-3,https://pubmed.ncbi.nlm.nih.gov/37194006/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,39295530,Short Chain Chlorinated Paraffins Impaired Spermatogenesis Process in Mice via Inhibiting α-KG/TET Enzyme Activity.,2024,10.1021/acs.est.4c05895,https://pubmed.ncbi.nlm.nih.gov/39295530/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,36607631,Sumoylation regulates functional properties of the oocyte transcription factors SOHLH1 and NOBOX.,2023,10.1096/fj.202201481r,https://pubmed.ncbi.nlm.nih.gov/36607631/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,38448741,Dysgerminoma Probably Due to a Novel SOHLH1-pathogenic Variant Causing Familial Ovarian Dysgenesis.,2024,10.1007/s43032-024-01492-0,https://pubmed.ncbi.nlm.nih.gov/38448741/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,36230452,F1 Male Sterility in Cattle-Yak Examined through Changes in Testis Tissue and Transcriptome Profiles.,2022,10.3390/ani12192711,https://pubmed.ncbi.nlm.nih.gov/36230452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,39849206,Rapid human oogonia-like cell specification via transcription factor-directed differentiation.,2025,10.1038/s44319-025-00371-2,https://pubmed.ncbi.nlm.nih.gov/39849206/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,35723319,The Transcriptional Cell Atlas of Testis Development in Sheep at Pre-Sexual Maturity.,2022,10.3390/cimb44020033,https://pubmed.ncbi.nlm.nih.gov/35723319/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,36980830,Effect of Dietetic Obesity on Testicular Transcriptome in Cynomolgus Monkeys.,2023,10.3390/genes14030557,https://pubmed.ncbi.nlm.nih.gov/36980830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,38181927,L-carnitine fails to rescue chemotherapy injured ovaries by epigenetic changes of transcription factors.,2024,10.1016/j.gene.2024.148128,https://pubmed.ncbi.nlm.nih.gov/38181927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,33236849,Stimulated by retinoic acid gene 8 (STRA8) interacts with the germ cell specific bHLH factor SOHLH1 and represses c-KIT expression in vitro.,2021,10.1111/jcmm.16087,https://pubmed.ncbi.nlm.nih.gov/33236849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,38135418,Decabromodiphenyl ether induces the chromosome association disorders of spermatocytes and deformation failures of spermatids in mice.,2024,10.1016/j.jes.2023.03.043,https://pubmed.ncbi.nlm.nih.gov/38135418/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,33407539,FSH regulates RA signaling to commit spermatogonia into differentiation pathway and meiosis.,2021,10.1186/s12958-020-00686-w,https://pubmed.ncbi.nlm.nih.gov/33407539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,34155740,Intrapleural infections in patients with subcutaneous panniculitis-like T-cell lymphoma are susceptible to hemophagocytic lymphohistiocytosis.,2021,10.1111/dth.15037,https://pubmed.ncbi.nlm.nih.gov/34155740/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,38664359,Evaluation of an Updated Gene Panel as a Diagnostic Tool for Both Male and Female Infertility.,2024,10.1007/s43032-024-01553-4,https://pubmed.ncbi.nlm.nih.gov/38664359/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,36228355,Decabromodiphenyl ethane induces male reproductive toxicity by glycolipid metabolism imbalance and meiotic failure.,2022,10.1016/j.ecoenv.2022.114165,https://pubmed.ncbi.nlm.nih.gov/36228355/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,37889105,Cyanidin-3-O-glucoside Mitigates the Ovarian Defect Induced by Zearalenone via p53-GADD45a Signaling during Primordial Follicle Assembly.,2023,10.1021/acs.jafc.3c03315,https://pubmed.ncbi.nlm.nih.gov/37889105/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,38008054,Melatonin alleviates the toxic effect of di(2-ethylhexyl) phthalate on oocyte quality resulting from CEBPB suppression during primordial follicle formation.,2024,10.1016/j.jhazmat.2023.132997,https://pubmed.ncbi.nlm.nih.gov/38008054/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,30988352,Single cell RNA-sequencing identified Dec2 as a suppressive factor for spermatogonial differentiation by inhibiting Sohlh1 expression.,2019,10.1038/s41598-019-42578-z,https://pubmed.ncbi.nlm.nih.gov/30988352/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,27460030,Endosulfan inhibiting the meiosis process via depressing expressions of regulatory factors and causing cell cycle arrest in spermatogenic cells.,2016,10.1007/s11356-016-7195-y,https://pubmed.ncbi.nlm.nih.gov/27460030/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,32164318,Loss of Cx43 in Murine Sertoli Cells Leads to Altered Prepubertal Sertoli Cell Maturation and Impairment of the Mitosis-Meiosis Switch.,2020,10.3390/cells9030676,https://pubmed.ncbi.nlm.nih.gov/32164318/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,30090449,Silica nanoparticles induce start inhibition of meiosis and cell cycle arrest via down-regulating meiotic relevant factors.,2016,10.1039/c6tx00236f,https://pubmed.ncbi.nlm.nih.gov/30090449/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,26053026,Adverse Effects of High Concentrations of Fluoride on Characteristics of the Ovary and Mature Oocyte of Mouse.,2015,10.1371/journal.pone.0129594,https://pubmed.ncbi.nlm.nih.gov/26053026/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOHLH1,ENSG00000165643,Unsafe,23190605,Overexpression of Uromodulin-like1 accelerates follicle depletion and subsequent ovarian degeneration.,2012,10.1038/cddis.2012.169,https://pubmed.ncbi.nlm.nih.gov/23190605/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,41761071,Genome-wide analysis of the SOS2 gene family in melon (Cucumis melo L.) and functional characterization of MELO3C010334 in response to salt stress.,2026,10.1186/s12870-026-08456-3,https://pubmed.ncbi.nlm.nih.gov/41761071/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,40545718,CaM4 Functions as a Positive Regulator of the SOS Pathway in Response to Salt Stress.,2025,10.1111/pce.70021,https://pubmed.ncbi.nlm.nih.gov/40545718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,42654945,Overexpression of Lotus &lt;i&gt;NnSWEET4a&lt;/i&gt; Alters Sugar Homeostasis and Induces Salt Hypersensitivity in &lt;i&gt;Arabidopsis&lt;/i&gt;.,2026,10.3390/plants15162542,https://pubmed.ncbi.nlm.nih.gov/42654945/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,41882629,SOS1: tracking the evolving path from promising to actionable therapeutic target in RAS-dependent cancers.,2026,10.1186/s12943-026-02632-7,https://pubmed.ncbi.nlm.nih.gov/41882629/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,40566682,The ESCRT component FYVE4 modulates salt-stress response by strengthening the SOS1-SOS2 interaction in Arabidopsis.,2025,10.1016/j.xplc.2025.101428,https://pubmed.ncbi.nlm.nih.gov/40566682/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,41816029,"A multimodal ultrasound approach: quantitative speed-of-sound, elastography, and B-mode imaging for predicting papillary thyroid carcinoma invasiveness.",2026,10.21037/qims-2025-1824,https://pubmed.ncbi.nlm.nih.gov/41816029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,40468845,Severe Nerve Enlargement in SOS2-Related Noonan Syndrome.,2025,10.1002/ajmg.a.64142,https://pubmed.ncbi.nlm.nih.gov/40468845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,41326795,RASH3D19 mediates RAS activation through a positive feedback loop in KRAS-mutant cancer.,2026,10.1038/s41556-025-01816-5,https://pubmed.ncbi.nlm.nih.gov/41326795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,42824961,Clinical consensus guidelines for the management of Noonan syndrome in Japan.,2026,10.1297/cpe.2026-0037,https://pubmed.ncbi.nlm.nih.gov/42824961/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,41600666,Transcriptome-Wide Identification and Analysis Reveals m6A Regulation of Porcine Intestinal Epithelial Cells Under TGEV Infection.,2025,10.3390/vetsci13010010,https://pubmed.ncbi.nlm.nih.gov/41600666/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,39900886,Targeting KDM4C Prevents Heart Failure after Acute Myocardial Infarction Via Activation of SOS2.,2025,10.1007/s12265-025-10594-2,https://pubmed.ncbi.nlm.nih.gov/39900886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,41345145,Alfalfa MsSOS2 confers salinity tolerance by promoting lateral root growth and regulating Na&lt;sup&gt;+&lt;/sup&gt;/K&lt;sup&gt;+&lt;/sup&gt; homeostasis.,2025,10.1038/s41598-025-21355-1,https://pubmed.ncbi.nlm.nih.gov/41345145/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,39884044,Heat stress enhances the expression of METTL3 to mediate N6-methyladenosine modification of SOS2 and NLRP3 inflammasome activation in boar Sertoli cells.,2025,10.1016/j.jhazmat.2025.137432,https://pubmed.ncbi.nlm.nih.gov/39884044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,42779230,LncRNA MtCIR2 Negatively Regulates Response of Medicago truncatula Seedlings to Salt Stress by Targeting SOS2-Dependent Na Efflux via H2A Ubiquitination.,2026,10.1111/pce.70904,https://pubmed.ncbi.nlm.nih.gov/42779230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,42089908,Functional characterization of citrus SOS genes reveals CsSOS2 as a key regulator of salinity tolerance in Carrizo citrange.,2026,10.1007/s00299-026-03839-0,https://pubmed.ncbi.nlm.nih.gov/42089908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,40033301,Sos1 ablation alters focal adhesion dynamics and increases Mmp2/9-dependent gelatinase activity in primary mouse embryonic fibroblasts.,2025,10.1186/s12964-025-02122-1,https://pubmed.ncbi.nlm.nih.gov/40033301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,39818983,Discovery of Small Molecules that Bind to Son of Sevenless 2 (SOS2).,2025,10.1021/acs.jmedchem.4c02007,https://pubmed.ncbi.nlm.nih.gov/39818983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,41929834,Carbon dots alleviate salinity stress and promote growth in tomato (&lt;i&gt;Solanum lycopersicum&lt;/i&gt;).,2026,10.3389/fpls.2026.1772618,https://pubmed.ncbi.nlm.nih.gov/41929834/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,41407845,"In-silico identification, characterization and expression analysis of salt overly sensitive-2 (SOS2) gene family in Gossypium hirsutum L. against abiotic stresses.",2025,10.1038/s41598-025-32353-8,https://pubmed.ncbi.nlm.nih.gov/41407845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,39963720,SALT OVERLY SENSITIVE2 and AMMONIUM TRANSPORTER1;1 contribute to plant salt tolerance by maintaining ammonium uptake.,2025,10.1093/plcell/koaf034,https://pubmed.ncbi.nlm.nih.gov/39963720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,39792473,SOS2 phosphorylates FREE1 to regulate multi-vesicular body trafficking and vacuolar dynamics under salt stress.,2025,10.1093/plcell/koaf012,https://pubmed.ncbi.nlm.nih.gov/39792473/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,38073064,SOS2 modulates the threshold of EGFR signaling to regulate osimertinib efficacy and resistance in lung adenocarcinoma.,2024,10.1002/1878-0261.13564,https://pubmed.ncbi.nlm.nih.gov/38073064/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,41855887,Brassica metabolite priming boosts growth and ion-water homeostasis under salt stress in broccoli.,2026,10.1016/j.jplph.2026.154747,https://pubmed.ncbi.nlm.nih.gov/41855887/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,38156904,Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography.,2024,10.1021/acs.jmedchem.3c02140,https://pubmed.ncbi.nlm.nih.gov/38156904/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,41558457,"S-nitrosoglutathione enhances rice tolerance to salt-submergence by coordinating ethylene, GA, and ABA accumulation and improving ion transport.",2026,10.1016/j.plaphy.2026.111036,https://pubmed.ncbi.nlm.nih.gov/41558457/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,39488215,Concurrent SOS1 and MEK suppression inhibits signaling and growth of NF1-null melanoma.,2024,10.1016/j.xcrm.2024.101818,https://pubmed.ncbi.nlm.nih.gov/39488215/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,42796777,&lt;i&gt;REM&lt;/i&gt; Gene Family in Sugar Beet and Functional &lt;i&gt;BvREM12&lt;/i&gt; in Salt Stress Tolerance.,2026,10.3390/plants15182745,https://pubmed.ncbi.nlm.nih.gov/42796777/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,42510565,&lt;i&gt;Ethylene-Responsive Transcription Factor 013&lt;/i&gt; Regulates Physiological and Molecular Responses to Salt Stress in &lt;i&gt;Arabidopsis thaliana&lt;/i&gt;.,2026,10.3390/antiox15070834,https://pubmed.ncbi.nlm.nih.gov/42510565/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,42433909,Comparative metabolomic and transcriptomic analysis revealing the role of salicylic acid for short-term response with arginine and myristic acid for long-term tolerance under salt stress in watermelon (&lt;i&gt;Citrullus lanatus&lt;/i&gt; L.).,2026,10.3389/fpls.2026.1823719,https://pubmed.ncbi.nlm.nih.gov/42433909/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,40412226,Helium governs nitric oxide signaling to improve alfalfa salinity tolerance by reestablishing redox and ion homeostasis.,2025,10.1016/j.plaphy.2025.110055,https://pubmed.ncbi.nlm.nih.gov/40412226/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,38612440,Unraveling the Contribution of MulSOS2 in Conferring Salinity Tolerance in Mulberry (Morus atropurpurea Roxb).,2024,10.3390/ijms25073628,https://pubmed.ncbi.nlm.nih.gov/38612440/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,39437166,SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma.,2025,10.1158/0008-5472.can-23-3256,https://pubmed.ncbi.nlm.nih.gov/39437166/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOS2,ENSG00000100485,Unsafe,38386704,Inverse regulation of SOS1 and HKT1 protein localization and stability by SOS3/CBL4 in Arabidopsis thaliana.,2024,10.1073/pnas.2320657121,https://pubmed.ncbi.nlm.nih.gov/38386704/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,41931180,Functional roles and clinical potential of SOX1 in cancer as a biomarker and therapeutic target.,2026,10.1007/s12672-026-04431-4,https://pubmed.ncbi.nlm.nih.gov/41931180/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,42002638,"Higher expression of SOX1, miR-155, and miR-21 in the colostrum of SARS-CoV-2-infected mothers.",2026,10.1038/s41598-026-49964-4,https://pubmed.ncbi.nlm.nih.gov/42002638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,42494433,Case Report: A case of paraneoplastic autoimmune encephalitis with concurrent anti-GABABR and anti-SOX1 antibody positivity.,2026,10.3389/fncel.2026.1816167,https://pubmed.ncbi.nlm.nih.gov/42494433/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,42388632,Anti-VGCC negative and Anti-SOX1 positive Lambert-Eaton myasthenic syndrome as the initial presentation of small cell lung cancer: a case report.,2026,10.3389/fonc.2026.1825530,https://pubmed.ncbi.nlm.nih.gov/42388632/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,41622162,Aberrant DNA methylation of SOX1 and PAX1 as epigenetic biomarkers and prognostic indicators in oral squamous cell carcinoma: a single-centre retrospective study.,2026,10.1186/s12903-026-07806-9,https://pubmed.ncbi.nlm.nih.gov/41622162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,42158422,Application of a modified MSRE-qPCR method for detecting circulating cell-free DNA methylation in cervical cancer.,2026,10.3389/fonc.2026.1759488,https://pubmed.ncbi.nlm.nih.gov/42158422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,41394839,Case Report: Anti-SOX1 antibody-associated limbic encephalitis with hippocampal sclerosis: the first autopsy case.,2025,10.3389/fimmu.2025.1688011,https://pubmed.ncbi.nlm.nih.gov/41394839/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,42278501,Comparative Analysis of Ectodermal Marker Expression in Human Adipose-Derived Stem Cells and Amniotic Epithelial Cells Exposed to Ectoderm-Inducing Conditions.,2026,10.3390/ijms27114976,https://pubmed.ncbi.nlm.nih.gov/42278501/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,41578161,Clinical Spectrum and Outcomes of SOX1 Antibody-Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study.,2026,10.1002/acn3.70313,https://pubmed.ncbi.nlm.nih.gov/41578161/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,40699796,Hypermethylation of &lt;i&gt;SOX1&lt;/i&gt; and &lt;i&gt;HOXA9&lt;/i&gt; Genes Is Associated with Clinicopathologic Characteristics of Non-Small Cell Lung Cancer Patients.,2025,10.3390/cimb47060397,https://pubmed.ncbi.nlm.nih.gov/40699796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,42166845,Decitabine inhibits the malignant transformation of oral potentially malignant disorders by upregulating SOX1 expression via demethylation to modulate the wnt pathway in a male rat model.,2026,10.1016/j.archoralbio.2026.106628,https://pubmed.ncbi.nlm.nih.gov/42166845/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,42196306,APOE4 Alters Early Transcriptional Programs and Inflammatory Signaling in Human Induced Pluripotent Stem Cells.,2026,10.3390/ijms27104325,https://pubmed.ncbi.nlm.nih.gov/42196306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,41542009,"Severe Anti-CV2/CRMP5, Anti-Hu, and Anti-SOX1 Antibody-Positive Paraneoplastic Neurological Syndrome Associated With Tumor Recurrence During Atezolizumab Therapy.",2025,10.7759/cureus.99224,https://pubmed.ncbi.nlm.nih.gov/41542009/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,41624872,Autoimmune encephalitis associated with antibodies against intracellular antigens in children.,2025,10.3389/fimmu.2025.1678497,https://pubmed.ncbi.nlm.nih.gov/41624872/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,41291493,Lambert-Eaton myasthenic syndrome presenting with occult mediastinal small cell carcinoma and positivity for anti-CV2/CRMP5 and anti-SOX1 antibodies: a case report.,2025,10.1186/s12883-025-04541-6,https://pubmed.ncbi.nlm.nih.gov/41291493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,42744285,Prolonged Post-Electroconvulsive Therapy Delirium in Treatment-Resistant Depression With Central Nervous System Risk Factors Under Programmed Cell Death Protein 1 Inhibitor Therapy: A Case Report.,2026,10.1097/yct.0000000000001324,https://pubmed.ncbi.nlm.nih.gov/42744285/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,42265288,Collagen IV outperforms alternative ECM coatings to preserve human neural progenitor properties on electrically conductive neural interfaces.,2026,10.1038/s41598-026-57453-x,https://pubmed.ncbi.nlm.nih.gov/42265288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,40162504,Nuclear factor I-C aggravates acute myelogenous leukemia by inhibiting SRY-box transcription factor 1 to activate autophagy.,2025,10.4149/neo_2025_240905n376,https://pubmed.ncbi.nlm.nih.gov/40162504/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,39681745,WTAP Regulates SOX1 Expression to Affect the Tumorigenicity of Colorectal Cancer via an m6A-YTHDF2-Dependent Manner.,2025,10.1007/s10620-024-08780-4,https://pubmed.ncbi.nlm.nih.gov/39681745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,41977478,Effects of Maternal Tetramethyl Bisphenol F Exposure on Neurodevelopment and Behavior in Mouse Offspring.,2026,10.3390/ijms27073299,https://pubmed.ncbi.nlm.nih.gov/41977478/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,41573575,Clinical characteristics and prognosis of paraneoplastic syndromes: a single-center cohort study in Northern China.,2025,10.3389/fimmu.2025.1715164,https://pubmed.ncbi.nlm.nih.gov/41573575/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,42749652,Paraneoplastic Neurological Syndrome in a Patient with Limited-stage Small-cell Lung Cancer Receiving Durvalumab Maintenance after Concurrent Chemoradiotherapy: A Case Report.,2026,10.2169/internalmedicine.7992-26,https://pubmed.ncbi.nlm.nih.gov/42749652/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,40620335,Diagnostic Significance of Paraneoplastic Neuronal Antibodies in Japanese Adults with Autoimmune Encephalitis: A Case Series Study in an Adult Epilepsy Clinic.,2025,10.2147/cpaa.s514609,https://pubmed.ncbi.nlm.nih.gov/40620335/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,41357218,Baseline neuronal antibodies in patients with small cell lung cancer are not necessarily associated with post-immune checkpoint inhibitors neurotoxicities.,2025,10.3389/fimmu.2025.1681765,https://pubmed.ncbi.nlm.nih.gov/41357218/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,41095886,"Clinical Features, Antibody Profiles, and Prognostic Factors in Autoimmune Encephalitis: A Single-Center Study.",2025,10.3390/jcm14196806,https://pubmed.ncbi.nlm.nih.gov/41095886/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,42699011,Diagnostic Accuracy of DNA Methylation Markers for Detecting Cervical Precancer and Cervical Cancer: A Systematic Review and Meta-analysis.,2026,10.22037/aaem.v14i1.3062,https://pubmed.ncbi.nlm.nih.gov/42699011/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,41555581,SOX1/PAX1 Methylation for Triage of HPV-Positive Women in Cervical Cancer Screening: A Cohort Study.,2026,10.1111/1471-0528.70162,https://pubmed.ncbi.nlm.nih.gov/41555581/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,40687918,PAX1/SOX1 gene methylation as a detection and triage method for triage of high risk HPV-Positive women in cervical cancer screening.,2025,10.1016/j.gore.2025.101794,https://pubmed.ncbi.nlm.nih.gov/40687918/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,41504982,Coexisting cerebellar ataxia and Lambert-Eaton myasthenic syndrome without malignancy: insights from a case and systematic literature review.,2026,10.1007/s10072-025-08589-7,https://pubmed.ncbi.nlm.nih.gov/41504982/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX1,ENSG00000182968,Unsafe,40385046,Paraneoplastic cerebellar degeneration combined with Lambert-Eaton myasthenia gravis syndrome in a patient positive for SOX1 antibody.,2025,10.62347/nhtj8584,https://pubmed.ncbi.nlm.nih.gov/40385046/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,42908613,"Duplication of the &lt;i&gt;SOX3&lt;/i&gt; gene in an &lt;i&gt;SRY&lt;/i&gt;-negative boy with a 46,XX karyotype: a case report and a review of the literature.",2026,10.3389/fgene.2026.1861766,https://pubmed.ncbi.nlm.nih.gov/42908613/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,42029673,Diverse SOX3 genetic variants and their associated phenotypic spectrum in human disease.,2026,10.1210/endrev/bnag008,https://pubmed.ncbi.nlm.nih.gov/42029673/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,41680906,Overexpression of SOX3 due to an X chromosome inversion leading to ovotesticular difference in sex development.,2026,10.1186/s13293-025-00822-4,https://pubmed.ncbi.nlm.nih.gov/41680906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,42729676,The Charcot-Marie-Tooth Neuropathy (CMTX3) Complex Structural Variation Causes Differential SOX3 Spatiotemporal Expression.,2026,10.1155/humu/4225263,https://pubmed.ncbi.nlm.nih.gov/42729676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,41300700,Molecular Characterization and Expression Patterns of &lt;i&gt;Sox3&lt;/i&gt; and &lt;i&gt;Sox30&lt;/i&gt; Genes and Response to Exogenous Hormones in the Chinese Soft-Shelled Turtle (&lt;i&gt;Pelodiscus sinensis&lt;/i&gt;).,2025,10.3390/genes16111249,https://pubmed.ncbi.nlm.nih.gov/41300700/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,42048305,Cytogenomic Investigation of Individuals with Ovotesticular Difference of Sex Development.,2026,10.1159/000551594,https://pubmed.ncbi.nlm.nih.gov/42048305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,42850448,"Dexamethasone suppresses the sox3 gene during tail regeneration in the electric black ghost knifefish, Apteronotus albifrons (Linnaeus 1766).",2026,10.1007/s00418-026-02538-x,https://pubmed.ncbi.nlm.nih.gov/42850448/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,41776093,Unrevealing the dual role of paired box and sex determining region Y related high mobility group box in glioblastoma.,2026,10.1007/s12672-026-04671-4,https://pubmed.ncbi.nlm.nih.gov/41776093/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,42497869,Position effect at the SOX3 locus by an interchromosomal insertion causes hereditary spastic paraplegia.,2026,10.1016/j.ajhg.2026.07.001,https://pubmed.ncbi.nlm.nih.gov/42497869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,42278634,"Integrated Transcriptome Landscape of mRNAs, lncRNAs, circRNAs, and miRNAs Reveals Molecular Regulatory Networks of Sex Differentiation in the Zig-Zag Eel (&lt;i&gt;Mastacembelus armatus&lt;/i&gt;).",2026,10.3390/ijms27115111,https://pubmed.ncbi.nlm.nih.gov/42278634/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,42569264,Epigenetic-metabolic coupling by SOX3/WDR5-SIRT5 signaling mediates the therapeutic effects of TGFβ-targeted exosomal nanoparticles in osteoarthritis.,2026,10.1016/j.mtbio.2026.103457,https://pubmed.ncbi.nlm.nih.gov/42569264/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,39766273,Disruption of Sex-Linked &lt;i&gt;Sox3&lt;/i&gt; Causes ZW Female-to-Male Sex Reversal in the Japanese Frog &lt;i&gt;Glandirana rugosa&lt;/i&gt;.,2024,10.3390/biom14121566,https://pubmed.ncbi.nlm.nih.gov/39766273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,41983446,Male germ cell-specific deletion of &lt;i&gt;Eif5&lt;/i&gt; causes the apoptosis of mouse progenitor spermatogonia by excessive endoplasmic reticulum stress and defective DNA repair.,2026,10.24272/j.issn.2095-8137.2025.220,https://pubmed.ncbi.nlm.nih.gov/41983446/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,42665132,Endocrine disrupting effects of estrone on male Siniperca chuatsi: From gonadal remodeling to gene regulation.,2027,10.1016/j.jsbmb.2026.107107,https://pubmed.ncbi.nlm.nih.gov/42665132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,41012776,SOX Family Members Expression in Canine Oral Melanoma: Role of the SOX3 in Tumor Aggressiveness.,2025,10.3390/vetsci12090851,https://pubmed.ncbi.nlm.nih.gov/41012776/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,41187170,Foxi2 and Sox3 are master transcription regulators that control ectoderm germ layer specification in Xenopus.,2025,10.1371/journal.pbio.3003476,https://pubmed.ncbi.nlm.nih.gov/41187170/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,42346119,Generation of Chimera-Competent Avian iPSCs Using Defined Transcription Factors.,2026,10.3390/cells15121092,https://pubmed.ncbi.nlm.nih.gov/42346119/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,41352536,RNA and ChIP-sequencing analysis reveals SOX3 suppresses antiviral innate immunity through the AKT1-PTEN signaling axis.,2025,10.1016/j.virs.2025.11.012,https://pubmed.ncbi.nlm.nih.gov/41352536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,40586822,SOX3 facilitates granulosa cell proliferation and suppresses cell apoptosis through modulating PI3K/AKT pathway by targeting SPP1.,2025,10.1007/s00018-025-05797-4,https://pubmed.ncbi.nlm.nih.gov/40586822/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,42453292,TGFβ signalling maintains Sox4+ astrocyte progenitors and restricts the early differentiation of BLBP+ astrocytes in the mouse dentate gyrus.,2026,10.3389/fncel.2026.1882016,https://pubmed.ncbi.nlm.nih.gov/42453292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,42356499,Synthesis and Development of Novel Small-Molecule MEIS2 Inhibitors That Induce Cell Death in Breast Cancer Cells by Targeting the Homeobox Domain.,2026,10.3390/ph19060881,https://pubmed.ncbi.nlm.nih.gov/42356499/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,41232283,Developmental toxicity of co-exposure of heavy metal and polystyrene microplastics in Xenopus laevis embryo.,2025,10.1016/j.scitotenv.2025.180903,https://pubmed.ncbi.nlm.nih.gov/41232283/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,38927713,Clinical Correlation of Transcription Factor SOX3 in Cancer: Unveiling Its Role in Tumorigenesis.,2024,10.3390/genes15060777,https://pubmed.ncbi.nlm.nih.gov/38927713/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,41734345,Human NT2/D1-derived early neural progenitor cells immobilised in alginate microfibres as an &lt;i&gt;in vitro&lt;/i&gt; 3D system for neurotoxicity testing.,2026,10.1177/02611929261428700,https://pubmed.ncbi.nlm.nih.gov/41734345/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,38891067,Transcription Factors Sox2 and Sox3 Directly Regulate the Expression of Genes Involved in the Onset of Oligodendrocyte Differentiation.,2024,10.3390/cells13110935,https://pubmed.ncbi.nlm.nih.gov/38891067/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,41514706,"High Doses of Norfloxacin Nicotinate Induce Apoptosis, Developmental Neurotoxicity, and Aberrant DNA Methylation in Zebrafish (&lt;i&gt;Danio rerio&lt;/i&gt;) Larvae.",2025,10.3390/ani16010018,https://pubmed.ncbi.nlm.nih.gov/41514706/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,42054264,Unraveling the Genetic Heterogeneity of Isolated Growth Hormone Deficiency: Insights from the GENHYPOPIT Cohort.,2026,10.1159/000551700,https://pubmed.ncbi.nlm.nih.gov/42054264/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,37749917,ROR2 deficit may induce the tetralogy of Fallot via down-regulating of β-catenin/SOX3/HSPA6 in vitro and in vivo.,2023,10.1111/jcmm.17969,https://pubmed.ncbi.nlm.nih.gov/37749917/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,35698877,Casein kinase 1α regulates murine spermatogenesis via p53-Sox3 signaling.,2022,10.1242/dev.200205,https://pubmed.ncbi.nlm.nih.gov/35698877/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,40216251,Loss of sex-determining region Y-box 2 (Sox2) captures embryonic stem cells in a primed pluripotent state.,2025,10.1016/j.jbc.2025.108501,https://pubmed.ncbi.nlm.nih.gov/40216251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,40181463,Biological pathways leading to septo-optic dysplasia: a review.,2025,10.1186/s13023-025-03541-6,https://pubmed.ncbi.nlm.nih.gov/40181463/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,34953010,Expression and significance of SOX B1 genes in glioblastoma multiforme patients.,2022,10.1111/jcmm.17120,https://pubmed.ncbi.nlm.nih.gov/34953010/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,32363730,Serum proteome profiling reveals SOX3 as a candidate prognostic marker for gastric cancer.,2020,10.1111/jcmm.15326,https://pubmed.ncbi.nlm.nih.gov/32363730/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX3,ENSG00000134595,Unsafe,42032984,Association of &lt;i&gt;QPRT&lt;/i&gt; gene polymorphisms with postpartum depression in Chinese cesarean parturients: A candidate gene association study.,2025,10.11817/j.issn.1672-7347.2025.250235,https://pubmed.ncbi.nlm.nih.gov/42032984/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,42510885,"Epigenetic Patterns in Musculoskeletal Disease: Methylation of &lt;i&gt;DKK1&lt;/i&gt;, &lt;i&gt;RHOJ&lt;/i&gt;, and &lt;i&gt;SOX6&lt;/i&gt; Genes in Osteoarthritis and Osteoporosis.",2026,10.3390/cimb48070644,https://pubmed.ncbi.nlm.nih.gov/42510885/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,42630156,"Integrated analysis of MYH6, MYH7, and MYH7B expression and their associated microRNAs in human end-stage heart failure.",2026,10.3389/fcvm.2026.1879458,https://pubmed.ncbi.nlm.nih.gov/42630156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,42422969,SOX6 is expressed in various cell lineages in the developing mouse heart and contributes to proper valvuloseptal development.,2026,10.1002/ar.70285,https://pubmed.ncbi.nlm.nih.gov/42422969/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,42012747,The Transcription Factor SOX6 Regulates Autophagy Levels Through LAMP5 to Inhibit the Development of Pituitary Adenomas.,2026,10.1007/s12010-026-05703-z,https://pubmed.ncbi.nlm.nih.gov/42012747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,42226351,Ocular Manifestations of Infectious Salmon Anaemia Virus Infection in Atlantic Salmon (Salmo salar).,2026,10.1111/jfd.70219,https://pubmed.ncbi.nlm.nih.gov/42226351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,40858115,Transient gene melting governs the timing of oligodendrocyte maturation.,2025,10.1016/j.cell.2025.07.039,https://pubmed.ncbi.nlm.nih.gov/40858115/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,41589677,Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors.,2026,10.7554/elife.100340,https://pubmed.ncbi.nlm.nih.gov/41589677/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,42564005,Sox5 controls cell cycle progression in intermediate progenitor cells during dentate gyrus development.,2026,10.3389/fcell.2026.1876208,https://pubmed.ncbi.nlm.nih.gov/42564005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,42244182,Integrated transcriptomic and functional analysis reveals tissue-specific molecular pathology in adolescent idiopathic scoliosis.,2026,10.1016/j.xhgg.2026.100631,https://pubmed.ncbi.nlm.nih.gov/42244182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,32757994,"Curcumin Suppresses Cell Proliferation, Migration, and Invasion Through Modulating miR-21-5p/&lt;i&gt;SOX6&lt;/i&gt; Axis in Hepatocellular Carcinoma.",2026,10.1089/cbr.2020.3734,https://pubmed.ncbi.nlm.nih.gov/32757994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,42509558,Integrating bulk and single-cell RNA sequencing with GWAS reveals regulatory networks underpinning complex traits in beef cattle.,2026,10.1186/s40104-026-01471-2,https://pubmed.ncbi.nlm.nih.gov/42509558/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,42310192,Engineering functional ventral midbrain dopaminergic neurons in human organoids through WNT modulation and bioreactor culture.,2026,10.1038/s41380-026-03667-4,https://pubmed.ncbi.nlm.nih.gov/42310192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,41616818,SOX6 is a novel host factor that promotes hepatitis B virus replication by enhancing the transcriptional activity of enhancer I.,2026,10.1016/j.antiviral.2026.106359,https://pubmed.ncbi.nlm.nih.gov/41616818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,40501408,SOX6 enhances vascular smooth muscle cell phenotypic switching and elevates blood pressure by activating autophagy.,2025,10.1002/ame2.70046,https://pubmed.ncbi.nlm.nih.gov/40501408/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,39379100,MIAT promotes myofibroblastic activities and transformation in oral submucous fibrosis through sponging the miR-342-3p/SOX6 axis.,2024,10.18632/aging.206121,https://pubmed.ncbi.nlm.nih.gov/39379100/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,40866912,A novel SOX6 + melanoma cell subtype promotes early microsatellite invasion in Asian acral melanoma through fatty acid transport disorder.,2025,10.1186/s13046-025-03516-2,https://pubmed.ncbi.nlm.nih.gov/40866912/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,41344818,Transcriptomic and experimental validation identifies SOX6 and LDLRAD3 as key factors in vascular dementia.,2026,10.1093/gerona/glaf262,https://pubmed.ncbi.nlm.nih.gov/41344818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,40912159,Evaluation of SOX6 immunohistochemical expression as a diagnostic marker in the distinction of epithelioid mesothelioma from lung carcinomas.,2026,10.1016/j.anndiagpath.2025.152553,https://pubmed.ncbi.nlm.nih.gov/40912159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,40818967,"Multi-omics approach reveals CCND1, GABPA, HIF1A, and SOX6 as key regulators and prognostic markers in heart failure.",2025,10.1186/s41065-025-00536-y,https://pubmed.ncbi.nlm.nih.gov/40818967/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,41997398,LncRNA PSMB8-AS1 contributes to post-infarction heart failure by aggravating myocardial injury and inflammation.,2026,10.1016/j.abb.2026.110825,https://pubmed.ncbi.nlm.nih.gov/41997398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,39573918,Sox6 and ALDH1A1 Truncation by Asparagine Endopeptidase Defines Selective Neuronal Vulnerability in Parkinson's Disease.,2025,10.1002/advs.202409477,https://pubmed.ncbi.nlm.nih.gov/39573918/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,39726326,Single-Cell RNA Sequencing Reveals the Tumor Heterogeneity and Immunosuppressive Microenvironment in Urothelial Carcinoma.,2025,10.1111/cas.16436,https://pubmed.ncbi.nlm.nih.gov/39726326/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,39262802,SOX6 expression and aneurysms of the thoracic and abdominal aorta.,2024,10.1016/j.isci.2024.110436,https://pubmed.ncbi.nlm.nih.gov/39262802/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,39619607,PACAP38 synergizes with irradiation to suppress the proliferation of multiple cancer cells via regulating SOX6/Wnt/β-catenin signaling.,2024,10.3389/fphar.2024.1492453,https://pubmed.ncbi.nlm.nih.gov/39619607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,41688785,MPTP and rotenone cause dopaminergic neuronal death by increasing DDIT4 promoter lactylation.,2026,10.1038/s41401-026-01748-2,https://pubmed.ncbi.nlm.nih.gov/41688785/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,41845016,Single-cell insights into trophoblast heterogeneity and adaptive dysfunction in selective fetal growth restriction.,2026,10.1038/s42003-026-09798-2,https://pubmed.ncbi.nlm.nih.gov/41845016/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,40808403,Nigrostriatal dopaminergic vulnerability in Parkinson's disease: Neuroprotective strategies.,2026,10.4103/nrr.nrr-d-25-00380,https://pubmed.ncbi.nlm.nih.gov/40808403/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,38848163,LncRNA MIR181A2HG inhibits keratinocytes proliferation through miR-223-3p/SOX6 axis.,2024,10.18632/aging.205902,https://pubmed.ncbi.nlm.nih.gov/38848163/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,41354962,Multi-omics research on moyamoya disease: current perspectives and future directions.,2025,10.1186/s12986-025-01066-0,https://pubmed.ncbi.nlm.nih.gov/41354962/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,40597588,Analysis of genomic selection characteristics of local cattle breeds in Gansu.,2025,10.1186/s12864-025-11753-0,https://pubmed.ncbi.nlm.nih.gov/40597588/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,40505591,In vitro evaluation of the biocompatibility and chondro-inductive potential of Kapton® for cartilage tissue engineering.,2025,10.1016/j.rvsc.2025.105755,https://pubmed.ncbi.nlm.nih.gov/40505591/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,39478117,Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages.,2024,10.1038/s43018-024-00773-6,https://pubmed.ncbi.nlm.nih.gov/39478117/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,36186474,Transcriptome sequencing analysis of the role of miR-499-5p and SOX6 in chicken skeletal myofiber specification.,2022,10.3389/fgene.2022.1008649,https://pubmed.ncbi.nlm.nih.gov/36186474/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,36069193,Neurodevelopmental disorder with dystonia due to SOX6 mutations.,2022,10.1002/mgg3.2051,https://pubmed.ncbi.nlm.nih.gov/36069193/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,36595751,Higher TYROBP and lower SOX6 as predictive biomarkers for poor prognosis of clear cell renal cell carcinoma: A pilot study.,2022,10.1097/md.0000000000030658,https://pubmed.ncbi.nlm.nih.gov/36595751/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,41299762,Deciphering the epigenomic regulatory variations reveals function diversity in adipose lineage among different adipose depots of pigs.,2025,10.1186/s13578-025-01513-8,https://pubmed.ncbi.nlm.nih.gov/41299762/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,37298481,Precision Editing as a Therapeutic Approach for β-Hemoglobinopathies.,2023,10.3390/ijms24119527,https://pubmed.ncbi.nlm.nih.gov/37298481/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,40660304,Blocking calcium-MYC regulatory axis inhibits early dedifferentiation of chondrocytes and contributes to cartilage regeneration.,2025,10.1186/s13287-025-04483-3,https://pubmed.ncbi.nlm.nih.gov/40660304/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SOX6,ENSG00000110693,Unsafe,11255018,"Cloning, characterization and chromosome mapping of the human SOX6 gene.",2001,10.1016/s0378-1119(01)00346-8,https://pubmed.ncbi.nlm.nih.gov/11255018/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,42780548,The SPA17-AXL axis drives melanoma aggressiveness and SPA17-targeting vaccination exhibits antitumor efficacy.,2026,10.3389/fimmu.2026.1914680,https://pubmed.ncbi.nlm.nih.gov/42780548/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,42473194,Clinical and molecular correlates of digitally quantified anthracosis in lung tissue slides: utility of an automated quantitative workflow.,2026,10.1002/2056-4538.70110,https://pubmed.ncbi.nlm.nih.gov/42473194/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,40740074,Electrochemical biosensing of sperm protein 17 in clinical samples using a hydrothermally synthesized MoS&lt;sub&gt;2&lt;/sub&gt;@rGO@MWCNTs ternary system without prior pre-treatment.,2025,10.1039/d5tb00741k,https://pubmed.ncbi.nlm.nih.gov/40740074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,41361190,Microbiota-host crosstalk: the role of short-term dietary restriction in neurological and metabolic dysregulation.,2025,10.1038/s41522-025-00857-w,https://pubmed.ncbi.nlm.nih.gov/41361190/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,41719382,"Genomic characterization of Sabiá virus in Brazil, 2019-2020: Implications for diagnostics, virus evolution, and receptor binding.",2026,10.1371/journal.pntd.0014008,https://pubmed.ncbi.nlm.nih.gov/41719382/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,40165483,Immunological Features and Potential Biomarkers of Systemic Sclerosis-Associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis.,2025,10.1111/crj.70072,https://pubmed.ncbi.nlm.nih.gov/40165483/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,41760906,Sparcl1 mitigates abdominal aortic aneurysm through inhibiting lymphangiogenesis-mediated TLS formation.,2026,10.1038/s41590-026-02454-1,https://pubmed.ncbi.nlm.nih.gov/41760906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,37835834,Characterization of Cancer/Testis Antigens as Prognostic Markers of Ovarian Cancer.,2023,10.3390/diagnostics13193092,https://pubmed.ncbi.nlm.nih.gov/37835834/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,40783878,Development and validation of G2M signature-based prognostic model for stratifying colon cancer prognosis.,2025,10.1007/s12672-025-03355-9,https://pubmed.ncbi.nlm.nih.gov/40783878/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,37224658,Sperm protein antigen 17 and Sperm flagellar 1 cancer testis antigens are expressed in a rare case of ciliated foregut cyst of the common hepatic duct.,2023,10.1016/j.prp.2023.154546,https://pubmed.ncbi.nlm.nih.gov/37224658/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,40944437,Siderophore-Dependent and -Independent Iron Acquisition Pathways in Marinobacter Nauticus SP17.,2025,10.1111/1462-2920.70176,https://pubmed.ncbi.nlm.nih.gov/40944437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,40158048,Spatial transcriptomic profiling of the human fallopian tube epithelium reveals region-specific gene expression patterns.,2025,10.1038/s42003-025-07871-w,https://pubmed.ncbi.nlm.nih.gov/40158048/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,40711514,Identification and functional annotation of candidate genes and transcription factors associated with reproductive traits to Nelore bulls: new insights from GWAS and post-GWAS analysis.,2025,10.1007/s11250-025-04558-6,https://pubmed.ncbi.nlm.nih.gov/40711514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,35592314,Sperm Autoantigenic Protein 17 Predicts the Prognosis and the Immunotherapy Response of Cancers: A Pan-Cancer Analysis.,2022,10.3389/fimmu.2022.844736,https://pubmed.ncbi.nlm.nih.gov/35592314/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,40278608,Isolation and Characterization of Aerobic and Facultative Anaerobic 17β-Estradiol Degrading Bacteria in Paddy Soils and Their Potential Mechanisms.,2025,10.3390/toxics13040292,https://pubmed.ncbi.nlm.nih.gov/40278608/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,40119264,Whole-genome bisulfite sequencing of X and Y sperm in Holstein bulls reveals differences in autosomal methylation status.,2025,10.1186/s12864-025-11402-6,https://pubmed.ncbi.nlm.nih.gov/40119264/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,35261795,The expression of cancer-testis antigen in ovarian cancer and the development of immunotherapy.,2022,,https://pubmed.ncbi.nlm.nih.gov/35261795/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,36292606,A Comparative Cross-Platform Analysis to Identify Potential Biomarker Genes for Evaluation of Teratozoospermia and Azoospermia.,2022,10.3390/genes13101721,https://pubmed.ncbi.nlm.nih.gov/36292606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,37695244,Decreased AKAP4/PKA signaling pathway in high DFI sperm affects sperm capacitation.,2024,10.4103/aja202329,https://pubmed.ncbi.nlm.nih.gov/37695244/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,31417875,Sperm Protein Antigen 17 Expression Correlates With Lymph Node Metastasis and Worse Overall Survival in Patients With Breast Cancer.,2019,10.3389/fonc.2019.00710,https://pubmed.ncbi.nlm.nih.gov/31417875/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,35463817,Design of a new multi-epitope peptide vaccine for non-small cell Lung cancer via vaccinology methods: an in silico study.,2022,10.22099/mbrc.2022.42468.1697,https://pubmed.ncbi.nlm.nih.gov/35463817/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,29245977,"The cancer-testis antigen, sperm protein 17, a new biomarker and immunological target in head and neck squamous cell carcinoma.",2017,10.18632/oncotarget.22213,https://pubmed.ncbi.nlm.nih.gov/29245977/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,33392854,Serum Sp17 Autoantibody Serves as a Potential Specific Biomarker in Patients with SAPHO Syndrome.,2021,10.1007/s10875-020-00937-w,https://pubmed.ncbi.nlm.nih.gov/33392854/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,31845450,Immunogenicity and contraceptive efficacy of recombinant fusion protein encompassing Sp17 spermatozoa-specific protein and GnRH: Relevance of adjuvants and microparticles based delivery to minimize number of injections.,2020,10.1111/aji.13218,https://pubmed.ncbi.nlm.nih.gov/31845450/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,30127274,Sperm Protein 17 Expression by Murine Epithelial Ovarian Cancer Cells and Its Impact on Tumor Progression.,2018,10.3390/cancers10080276,https://pubmed.ncbi.nlm.nih.gov/30127274/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,29088794,Cancer testis antigen Sperm Protein 17 as a new target for triple negative breast cancer immunotherapy.,2017,10.18632/oncotarget.20102,https://pubmed.ncbi.nlm.nih.gov/29088794/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,29204156,Sp17 Protein Expression and Major Histocompatibility Class I and II Epitope Presentation in Diffuse Large B Cell Lymphoma Patients.,2017,10.1155/2017/6527306,https://pubmed.ncbi.nlm.nih.gov/29204156/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPA17,ENSG00000064199,Unsafe,27618037,"In Vitro Assessment of the Expression and T Cell Immunogenicity of the Tumor-Associated Antigens BORIS, MUC1, hTERT, MAGE-A3 and Sp17 in Uterine Cancer.",2016,10.3390/ijms17091525,https://pubmed.ncbi.nlm.nih.gov/27618037/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,42339479,Effects of resveratrol supplementation to equine sperm during semen cryopreservation.,2026,10.1590/1984-3143-ar2025-0107,https://pubmed.ncbi.nlm.nih.gov/42339479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,41518220,Niacin Improves Cryopreserved Equine Sperm Quality and Gene Expression: An Artificial Intelligence Assisted Evaluation.,2026,10.1111/rda.70173,https://pubmed.ncbi.nlm.nih.gov/41518220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,40137503,Oxidative and Molecular-Structural Alterations of Spermatozoa in Swine and Ram Exposed to the Triazole Ipconazole.,2025,10.3390/toxics13030176,https://pubmed.ncbi.nlm.nih.gov/40137503/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,40295237,Causal relationships between gut microbiota and male reproductive inflammation and infertility: Insights from Mendelian randomization.,2025,10.1097/md.0000000000042323,https://pubmed.ncbi.nlm.nih.gov/40295237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,40276155,Proteomic analysis of Toraya buffalo seminal plasma and sperm: uncovering insights to optimize reproductive success.,2025,10.3389/fvets.2025.1492135,https://pubmed.ncbi.nlm.nih.gov/40276155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,37118964,Differential Proteomic Analysis of Human Sperm: A Systematic Review to Identify Candidate Targets to Monitor Sperm Quality.,2024,10.5534/wjmh.220262,https://pubmed.ncbi.nlm.nih.gov/37118964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,39142616,"Effect of naringenin on post-thaw quality, fertility-associated gene expression and fertilization potential of buffalo (Bubalus bubalis) bull sperm.",2024,10.1016/j.cryobiol.2024.104953,https://pubmed.ncbi.nlm.nih.gov/39142616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,38268214,"Ameliorative effect of crocin on post-thaw quality, fertility-associated gene expression and fertilization potential of buffalo (Bubalus bubalis) bull sperm.",2024,10.1111/rda.14519,https://pubmed.ncbi.nlm.nih.gov/38268214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,37230456,Effects of cryopreservation in the presence of Natural Deep Eutectic Solvents (NADESs) on sperm parameters.,2023,10.1016/j.cryobiol.2023.05.007,https://pubmed.ncbi.nlm.nih.gov/37230456/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,33290900,Biological features of tissue and bone sarcomas investigated using an in vitro model of clonal selection.,2021,10.1016/j.prp.2020.153214,https://pubmed.ncbi.nlm.nih.gov/33290900/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,24872021,SPACA3 gene variants in a New Zealand cohort of infertile and fertile couples.,2014,10.3109/14647273.2014.907506,https://pubmed.ncbi.nlm.nih.gov/24872021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,37020592,The role of spermatozoa-zona pellucida interaction in selecting fertilization-competent spermatozoa in humans.,2023,10.3389/fendo.2023.1135973,https://pubmed.ncbi.nlm.nih.gov/37020592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,26088750,Cancer-testis antigen SLLP1 represents a promising target for the immunotherapy of multiple myeloma.,2015,10.1186/s12967-015-0562-5,https://pubmed.ncbi.nlm.nih.gov/26088750/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,27832206,"Structural, Functional and Phylogenetic Analysis of Sperm Lysozyme-Like Proteins.",2016,10.1371/journal.pone.0166321,https://pubmed.ncbi.nlm.nih.gov/27832206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,27611690,In Silico and Biochemical Characterization of Lysozyme-Like Proteins in the Rat.,2016,10.1371/journal.pone.0161909,https://pubmed.ncbi.nlm.nih.gov/27611690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,22110709,Characterization of a novel lysozyme-like 4 gene in the rat.,2011,10.1371/journal.pone.0027659,https://pubmed.ncbi.nlm.nih.gov/22110709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,32602977,The effect of astaxanthin supplementation on the post-thaw quality of dog semen.,2020,10.1111/rda.13758,https://pubmed.ncbi.nlm.nih.gov/32602977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,35395711,Bioinformatics analysis reveals immune prognostic markers for overall survival of colorectal cancer patients: a novel machine learning survival predictive system.,2022,10.1186/s12859-022-04657-3,https://pubmed.ncbi.nlm.nih.gov/35395711/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,25038051,The role of SPRASA in female fertility.,2015,10.1177/1933719114542009,https://pubmed.ncbi.nlm.nih.gov/25038051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,26198801,"Sperm Lysozyme-Like Protein 1 (SLLP1), an intra-acrosomal oolemmal-binding sperm protein, reveals filamentous organization in protein crystal form.",2015,10.1111/andr.12057,https://pubmed.ncbi.nlm.nih.gov/26198801/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,32812178,Prognostication of a 13-immune-related-gene signature in patients with early triple-negative breast cancer.,2020,10.1007/s10549-020-05874-1,https://pubmed.ncbi.nlm.nih.gov/32812178/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,24038607,SAS1B protein [ovastacin] shows temporal and spatial restriction to oocytes in several eutherian orders and initiates translation at the primary to secondary follicle transition.,2013,10.1002/dvdy.24040,https://pubmed.ncbi.nlm.nih.gov/24038607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,25191655,"Optimization of the IPP Precursor Supply for the Production of Lycopene, Decaprenoxanthin and Astaxanthin by Corynebacterium glutamicum.",2014,10.3389/fbioe.2014.00028,https://pubmed.ncbi.nlm.nih.gov/25191655/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,21898529,Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia.,2011,10.1002/ajh.22141,https://pubmed.ncbi.nlm.nih.gov/21898529/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,15475442,"The spermatozoa protein, SLLP1, is a novel cancer-testis antigen in hematologic malignancies.",2004,10.1158/1078-0432.ccr-04-0911,https://pubmed.ncbi.nlm.nih.gov/15475442/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,16929165,Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma.,2006,10.4161/cbt.5.9.3174,https://pubmed.ncbi.nlm.nih.gov/16929165/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,17312182,Cancer/testis genes in multiple myeloma: expression patterns and prognosis value determined by microarray analysis.,2007,10.4049/jimmunol.178.5.3307,https://pubmed.ncbi.nlm.nih.gov/17312182/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,16014814,"Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family.",2005,10.1095/biolreprod.105.041889,https://pubmed.ncbi.nlm.nih.gov/16014814/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA3,ENSG00000141316,Unsafe,12606493,"SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa.",2003,10.1095/biolreprod.102.010108,https://pubmed.ncbi.nlm.nih.gov/12606493/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA9,ENSG00000165698,Unsafe,42286192,SPACA9 and MNMIP1 bridge the seam of spermatid manchette microtubules.,2026,10.1038/s44318-026-00833-w,https://pubmed.ncbi.nlm.nih.gov/42286192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA9,ENSG00000165698,Unsafe,40453182,"Development of a procedure for isolation, identification and quality assessment of bovine spermatids and evaluation of their fertilizing ability &lt;i&gt;in vitro&lt;/i&gt;.",2025,10.3389/fbioe.2025.1581019,https://pubmed.ncbi.nlm.nih.gov/40453182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA9,ENSG00000165698,Unsafe,36830681,Loss of Tumor Suppressor C9orf9 Promotes Metastasis in Colorectal Cancer.,2023,10.3390/biom13020312,https://pubmed.ncbi.nlm.nih.gov/36830681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA9,ENSG00000165698,Unsafe,36191189,SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.,2022,10.1073/pnas.2207605119,https://pubmed.ncbi.nlm.nih.gov/36191189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA9,ENSG00000165698,Unsafe,37865089,De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking.,2023,10.1016/j.cell.2023.09.017,https://pubmed.ncbi.nlm.nih.gov/37865089/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA9,ENSG00000165698,Unsafe,30820981,Comparative proteomic analysis of high- and low-fertile buffalo bull spermatozoa for identification of fertility-associated proteins.,2019,10.1111/rda.13426,https://pubmed.ncbi.nlm.nih.gov/30820981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA9,ENSG00000165698,Unsafe,19334046,Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer.,2009,10.1002/path.2520,https://pubmed.ncbi.nlm.nih.gov/19334046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACA9,ENSG00000165698,Unsafe,15239131,Expression in bladder transitional cell carcinoma by real-time quantitative reverse transcription polymerase chain reaction array of 65 genes at the tumor suppressor locus 9q34.1-2: identification of 5 candidates tumor suppressor genes.,2004,10.1002/ijc.20283,https://pubmed.ncbi.nlm.nih.gov/15239131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACDR,ENSG00000185955,Unsafe,38863317,Testis-Specific Gene C7orf61 Is Involved in Mouse Sperm-Egg Fusion.,2024,10.22037/uj.v21i.8073,https://pubmed.ncbi.nlm.nih.gov/38863317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACDR,ENSG00000185955,Unsafe,41302093,Genome-Wide Association Study for Milk Protein Content in Romanian Dual-Purpose Cattle.,2025,10.3390/life15111668,https://pubmed.ncbi.nlm.nih.gov/41302093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACDR,ENSG00000185955,Unsafe,31985809,Exome sequencing reveals novel causes as well as new candidate genes for human globozoospermia.,2020,10.1093/humrep/dez246,https://pubmed.ncbi.nlm.nih.gov/31985809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACDR,ENSG00000185955,Unsafe,34580317,Integration and gene co-expression network analysis of scRNA-seq transcriptomes reveal heterogeneity and key functional genes in human spermatogenesis.,2021,10.1038/s41598-021-98267-3,https://pubmed.ncbi.nlm.nih.gov/34580317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACDR,ENSG00000185955,Unsafe,36047070,Globozoospermia: A Case Report and Systematic Review of Literature.,2023,10.5534/wjmh.220020,https://pubmed.ncbi.nlm.nih.gov/36047070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPACDR,ENSG00000185955,Unsafe,23634713,Evaluation of potential protein biomarkers in patients with high sperm DNA damage.,2013,10.3109/19396368.2013.775396,https://pubmed.ncbi.nlm.nih.gov/23634713/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,42650068,&lt;i&gt;SPAG1&lt;/i&gt; Expression as a Candidate Predictor of Pathological Lymph Node Metastasis in Prostate Cancer: A Transcriptomic Analysis of The Cancer Genome Atlas Prostate Adenocarcinoma Cohort.,2026,10.3390/genes17080875,https://pubmed.ncbi.nlm.nih.gov/42650068/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,42837447,DNAAF19-RUVBL1/2 complex recruits multiple adaptors to promote dynein arm assembly.,2026,10.1073/pnas.2612755123,https://pubmed.ncbi.nlm.nih.gov/42837447/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,42772652,Integrative multi-omics and Mendelian randomization analysis reveals immune-epigenetic crosstalk potentially involved in cervical carcinogenesis.,2026,10.1016/j.freeradbiomed.2026.09.021,https://pubmed.ncbi.nlm.nih.gov/42772652/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,42575707,A Novel Frameshift Variant in SPAG1 Likely Causes Primary Ciliary Dyskinesia in Cocker Spaniels in Australia.,2026,10.1002/age.70183,https://pubmed.ncbi.nlm.nih.gov/42575707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,41667496,An integrative structural biology approach reveals the dynamic organization of the R2SP quaternary chaperone complex.,2026,10.1038/s41467-026-69157-x,https://pubmed.ncbi.nlm.nih.gov/41667496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,39364610,Promoter Deletion Leading to Allele Specific Expression in a Genetically Unsolved Case of Primary Ciliary Dyskinesia.,2025,10.1002/ajmg.a.63880,https://pubmed.ncbi.nlm.nih.gov/39364610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,41398765,A cancer-testis antigen signature for predicting prognosis and response to immunotherapy in acute myeloid leukemia.,2025,10.1097/md.0000000000046374,https://pubmed.ncbi.nlm.nih.gov/41398765/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,40746734,The lack of homozygotes with a large deletion encompassing &lt;i&gt;SPAG1&lt;/i&gt; and &lt;i&gt;POLR2K&lt;/i&gt; in primary ciliary dyskinesia patients suggests the lethal effect of the loss of POLR2K protein.,2025,10.1016/j.gendis.2025.101535,https://pubmed.ncbi.nlm.nih.gov/40746734/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,35178554,The role of SPAG1 in the assembly of axonemal dyneins in human airway epithelia.,2022,10.1242/jcs.259512,https://pubmed.ncbi.nlm.nih.gov/35178554/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,39520808,Impact of gonadotropin on certain testis-related genes identified through testicular transcriptome analysis in the Asian and the African catfish.,2024,10.1016/j.cbd.2024.101349,https://pubmed.ncbi.nlm.nih.gov/39520808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,38491953,Analysis of clinical characteristics and histopathological transcription in 40 patients afflicted by epilepsy stemming from focal cortical dysplasia.,2024,10.1002/epi4.12928,https://pubmed.ncbi.nlm.nih.gov/38491953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,37568830,Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins.,2023,10.3390/diagnostics13152468,https://pubmed.ncbi.nlm.nih.gov/37568830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,41454275,Genome-wide identifications of regulatory variants influencing milk fat percentage in Chinese Holstein cow.,2025,10.1186/s12864-025-12449-1,https://pubmed.ncbi.nlm.nih.gov/41454275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,41299435,Immune cell-based transcriptomic Mendelian randomization and colocalization study on type 1 diabetes.,2025,10.1186/s12916-025-04527-8,https://pubmed.ncbi.nlm.nih.gov/41299435/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,41553716,"Dioxin, an endocrine disruptor, induces long term effects on DNA methylation in men after in-utero exposure.",2026,10.23736/s2724-6507.25.04276-9,https://pubmed.ncbi.nlm.nih.gov/41553716/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,35227274,Comprehensive analysis of SPAG1 expression as a prognostic and predictive biomarker in acute myeloid leukemia by integrative bioinformatics and clinical validation.,2022,10.1186/s12920-022-01193-0,https://pubmed.ncbi.nlm.nih.gov/35227274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,33888993,Expression and Prognosis of Sperm-Associated Antigen 1 in Human Breast Cancer.,2021,10.2147/ott.s288484,https://pubmed.ncbi.nlm.nih.gov/33888993/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,35951456,SPAG1 promotes the development of AML by activating the ERK/MAPK signaling pathway and affects the chemotherapy sensitivity of venetoclax.,2022,10.4149/neo_2022_220415n416,https://pubmed.ncbi.nlm.nih.gov/35951456/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,40723324,Genomic Analysis of Adaptability and Genetic Structure of Jabal Akhdar Goats: Evidence of Positive Selection in an Indigenous Omani Breed.,2025,10.3390/biology14070761,https://pubmed.ncbi.nlm.nih.gov/40723324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,39411815,Construction and validation of a histone-related gene signature for the diagnosis of endometriosis.,2025,10.5603/gpl.96199,https://pubmed.ncbi.nlm.nih.gov/39411815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,33883344,Detection of novel and recurrent conjoined genes in non-Hodgkin B-cell lymphoma.,2021,10.3960/jslrt.20033,https://pubmed.ncbi.nlm.nih.gov/33883344/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,36951526,Germline genetic variants and pediatric rhabdomyosarcoma outcomes: a report from the Children's Oncology Group.,2023,10.1093/jnci/djad055,https://pubmed.ncbi.nlm.nih.gov/36951526/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,21150711,Sperm-associated antigens as targets for cancer immunotherapy: expression pattern and humoral immune response in cancer patients.,2011,10.1097/cji.0b013e3181fb64fa,https://pubmed.ncbi.nlm.nih.gov/21150711/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,28149327,In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain.,2017,10.1186/s13072-017-0111-y,https://pubmed.ncbi.nlm.nih.gov/28149327/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,27861489,Characterizing Transcriptional Networks in Male Rainbow Darter (Etheostoma caeruleum) that Regulate Testis Development over a Complete Reproductive Cycle.,2016,10.1371/journal.pone.0164722,https://pubmed.ncbi.nlm.nih.gov/27861489/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,24055112,Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms.,2013,10.1016/j.ajhg.2013.07.025,https://pubmed.ncbi.nlm.nih.gov/24055112/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,16983343,Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells.,2007,10.1038/sj.onc.1209961,https://pubmed.ncbi.nlm.nih.gov/16983343/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,11517287,Expression and function of the HSD-3.8 gene encoding a testis-specific protein.,2001,10.1093/molehr/7.9.811,https://pubmed.ncbi.nlm.nih.gov/11517287/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG1,ENSG00000104450,Unsafe,1299558,Isolation and sequencing of the cDNA encoding the 75-kD human sperm protein related to infertility.,1992,,https://pubmed.ncbi.nlm.nih.gov/1299558/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,42723868,"The double-edged role of SPAG6 in male reproductive toxicity: pro-invasive in leukemia, protective in germ cells.",2026,10.3389/fmed.2026.1855817,https://pubmed.ncbi.nlm.nih.gov/42723868/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,41685588,Role of SPAG6 in regulating physiological functions and tumorigenesis (Review).,2026,10.3892/ijo.2026.5855,https://pubmed.ncbi.nlm.nih.gov/41685588/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,40497959,"Mouse SPAG6L, a Key Cytoskeleton Modulator Essential for Male Germ Cell Development, Is Not Required for Sertoli Cell Function.",2025,10.3390/cells14110783,https://pubmed.ncbi.nlm.nih.gov/40497959/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,41066509,The Janus Face of SPAG6: Inducing EMT in Luminal Breast Cancer Cells Amidst Widespread Expression Loss in Breast Tumours.,2025,10.1111/jcmm.70870,https://pubmed.ncbi.nlm.nih.gov/41066509/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,42095086,Syncytin-a deficiency compromises murine sperm function by suppressing PRL/PGE2 and PI3K/AKT/mTOR pathway.,2026,10.1016/j.isci.2026.115694,https://pubmed.ncbi.nlm.nih.gov/42095086/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,40535772,SPAG6 Promotes Multiple Myeloma Through Activation of the MAPK/ERK Signaling Pathway.,2025,10.3389/fphar.2025.1572621,https://pubmed.ncbi.nlm.nih.gov/40535772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,41042741,RETRACTED: SPAG6 hypermethylation silences a novel tumor suppressor and inhibits renal cell carcinoma progression via PI3K/AKT/mTOR pathway.,2025,10.1371/journal.pone.0333202,https://pubmed.ncbi.nlm.nih.gov/41042741/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,42643619,A Novel Homozygous Mutation in &lt;i&gt;ARL2BP&lt;/i&gt; Causes Multiple Morphological Abnormalities of the Flagella and Primary Ciliary Dyskinesia.,2026,10.1155/humu/7635300,https://pubmed.ncbi.nlm.nih.gov/42643619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,42785075,Identification and evaluation of candidate sperm proteins associated with cryopreservation-induced changes in semen quality in Thai native roosters.,2026,10.1016/j.psj.2026.107802,https://pubmed.ncbi.nlm.nih.gov/42785075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,39015705,"A comprehensive pan-cancer analysis revealing SPAG6 as a novel diagnostic, prognostic and immunological biomarker in tumor.",2024,10.21037/gs-24-157,https://pubmed.ncbi.nlm.nih.gov/39015705/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,40260407,Investigating cigarette smoke-induced airway inflammation and sperm activity impairment in rats based on cilia-associated proteins.,2025,10.1007/s13205-025-04302-9,https://pubmed.ncbi.nlm.nih.gov/40260407/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,40145872,CircMYH9 promotes the mRNA stability of SPAG6 by recruiting EIF4A3 to facilitate the progression of breast cancer.,2025,10.1080/15592294.2025.2482382,https://pubmed.ncbi.nlm.nih.gov/40145872/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,39508041,SPAG6 overexpression decreases the pro-apoptotic effect of daunorubicin in acute myeloid leukemia cells through the ROS/JNK MAPK axis in a GSTP1-dependent manner.,2024,10.3389/fphar.2024.1390456,https://pubmed.ncbi.nlm.nih.gov/39508041/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,37169167,The Function of Spag6 to Repair Brain Edema Damage After Cerebral Ischemic Stroke-reperfusion.,2023,10.1016/j.neuroscience.2023.04.014,https://pubmed.ncbi.nlm.nih.gov/37169167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,40462294,Spatial Transcriptomics Shows a Distinctive Tumour Microenvironment in the Invasive Versus Premalignant Portion of Early Cutaneous Squamous Cell Carcinoma.,2025,10.1111/exd.70125,https://pubmed.ncbi.nlm.nih.gov/40462294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,40152050,High Expression of SPAG6 Acts as a Pro-Tumor Factor and Associated With Poor Prognosis in Acute Myeloid Leukemia.,2025,10.1111/ijlh.14457,https://pubmed.ncbi.nlm.nih.gov/40152050/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,35159146,The Ancient and Evolved Mouse Sperm-Associated Antigen 6 Genes Have Different Biologic Functions In Vivo.,2022,10.3390/cells11030336,https://pubmed.ncbi.nlm.nih.gov/35159146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,38147275,SPAG6 regulates cell proliferation and apoptosis via TGF-β/Smad signal pathway in adult B-cell acute lymphoblastic leukemia.,2024,10.1007/s12185-023-03684-x,https://pubmed.ncbi.nlm.nih.gov/38147275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,37681349,Upregulated SPAG6 correlates with increased STAT1 and is associated with reduced sensitivity of interferon-α response in BCR::ABL1 negative myeloproliferative neoplasms.,2023,10.1111/cas.15950,https://pubmed.ncbi.nlm.nih.gov/37681349/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,38027210,RNA sequencing profiles reveals progressively reduced spermatogenesis with progression in adult cryptorchidism.,2023,10.3389/fendo.2023.1271724,https://pubmed.ncbi.nlm.nih.gov/38027210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,36398260,DNMT3b-mediated SPAG6 promoter hypermethylation affects lung squamous cell carcinoma development through the JAK/STAT pathway.,2022,,https://pubmed.ncbi.nlm.nih.gov/36398260/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,36199573,Aberrant expression of SPAG6 and NM23 predicts poor prognosis of human osteosarcoma.,2022,10.3389/fgene.2022.1012548,https://pubmed.ncbi.nlm.nih.gov/36199573/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,40457935,A novel frameshift variant in AXDND1 may cause multiple morphological abnormalities of the sperm flagella in a consanguineous Pakistani family.,2025,10.4103/aja202538,https://pubmed.ncbi.nlm.nih.gov/40457935/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,35590199,"Delayed fractional dosing with RTS,S/AS01 improves humoral immunity to malaria via a balance of polyfunctional NANP6- and Pf16-specific antibodies.",2021,10.1016/j.medj.2021.10.003,https://pubmed.ncbi.nlm.nih.gov/35590199/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,40486681,Distinct germ-line genetic mutation patterns correlate with reproductive outcomes in ICSI patients: a pilot study.,2025,10.3389/fgene.2025.1610943,https://pubmed.ncbi.nlm.nih.gov/40486681/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,31660426,The Emerging Role of Sperm-Associated Antigen 6 Gene in the Microtubule Function of Cells and Cancer.,2019,10.1016/j.omto.2019.08.011,https://pubmed.ncbi.nlm.nih.gov/31660426/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,34950701,Identification of a Five-Gene Signature Derived From MYCN Amplification and Establishment of a Nomogram for Predicting the Prognosis of Neuroblastoma.,2021,10.3389/fmolb.2021.769661,https://pubmed.ncbi.nlm.nih.gov/34950701/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,37001189,Microcystin leucine arginine induces human sperm damage: Involvement of the Ca2+/CaMKKβ/AMPK pathway.,2023,10.1016/j.ecoenv.2023.114845,https://pubmed.ncbi.nlm.nih.gov/37001189/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,36246315,Regulatory effects of differential dietary energy levels on spermatogenesis and sperm motility of yellow-feathered breeder cocks.,2022,10.3389/fvets.2022.964620,https://pubmed.ncbi.nlm.nih.gov/36246315/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,27169488,Impaired immunological synapse in sperm associated antigen 6 (SPAG6) deficient mice.,2016,10.1038/srep25840,https://pubmed.ncbi.nlm.nih.gov/27169488/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,21150711,Sperm-associated antigens as targets for cancer immunotherapy: expression pattern and humoral immune response in cancer patients.,2011,10.1097/cji.0b013e3181fb64fa,https://pubmed.ncbi.nlm.nih.gov/21150711/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG6,ENSG00000077327,Unsafe,10493827,cDNA cloning and characterization of a human sperm antigen (SPAG6) with homology to the product of the Chlamydomonas PF16 locus.,1999,10.1006/geno.1999.5914,https://pubmed.ncbi.nlm.nih.gov/10493827/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,39846792,"Truncated SPAG9 as a novel candidate gene for a new syndrome: Coarse facial features, albinism, cataract and developmental delay (CACD syndrome).",2025,10.1590/1678-4685-gmb-2024-0094,https://pubmed.ncbi.nlm.nih.gov/39846792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,41176051,Cancer-testis antigens (CTAs) in lung cancer.,2026,10.1016/j.cca.2025.120687,https://pubmed.ncbi.nlm.nih.gov/41176051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,42249300,Semi-automatic 3D-quantification of in-vivo synapse formation.,2026,10.1186/s12859-026-06480-6,https://pubmed.ncbi.nlm.nih.gov/42249300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,42869898,"Single-cell, spatial, and machine learning analyses identify ANKIB1 as an oligodendrocyte-anchored palmitoylation-associated candidate biomarker of Alzheimer's disease.",2026,10.1038/s41398-026-04463-y,https://pubmed.ncbi.nlm.nih.gov/42869898/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,34380828,Significance of cancer testis-associated antigens (SPAG9 and FBXO39) in colon cancer.,2022,10.4103/ijc.ijc_873_19,https://pubmed.ncbi.nlm.nih.gov/34380828/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,41911957,Transcriptome and alternative splicing analyses uncover immune-centric pathogenesis in periodontitis versus barrier-dysfunction-driven pathogenesis in peri-implantitis.,2026,10.1016/j.gene.2026.150114,https://pubmed.ncbi.nlm.nih.gov/41911957/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,41420843,Immune Surveillance in Chronic Myeloid Leukemia: Tumor Antigen Expression and CD8&lt;sup&gt;+&lt;/sup&gt; T Cell Function in the Context of Treatment- Free Remission.,2026,10.2478/aite-2026-0004,https://pubmed.ncbi.nlm.nih.gov/41420843/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,37107702,SPAG9 Expression Predicts Good Prognosis in Patients with Clear-Cell Renal Cell Carcinoma: A Bioinformatics Analysis with Experimental Validation.,2023,10.3390/genes14040944,https://pubmed.ncbi.nlm.nih.gov/37107702/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,40302679,Proteomics unveils chemical modifications on protein side chains in raw breast meat of broilers (Gallus gallus) affected with growth-related myopathies.,2025,10.5713/ab.24.0892,https://pubmed.ncbi.nlm.nih.gov/40302679/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,40013273,Sperm protein profile and their correlation with frozen semen quality of indigenous Indonesian buffalo bulls.,2024,10.5455/javar.2024.k836,https://pubmed.ncbi.nlm.nih.gov/40013273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,37106775,Electrostatic Complementarities of Glioblastoma-Resident T-Cell Receptors and Cancer Testis Antigens Linked to Poor Outcomes and High Levels of Sphingosine Kinase-2 Expression.,2023,10.3390/biology12040575,https://pubmed.ncbi.nlm.nih.gov/37106775/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,36780531,An HLA-G/SPAG9/STAT3 axis promotes brain metastases.,2023,10.1073/pnas.2205247120,https://pubmed.ncbi.nlm.nih.gov/36780531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,35574342,"Cancer/Testis Antigens as Biomarker and Target for the Diagnosis, Prognosis, and Therapy of Lung Cancer.",2022,10.3389/fonc.2022.864159,https://pubmed.ncbi.nlm.nih.gov/35574342/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,37993474,Bioinformatics analysis and machine learning approach applied to the identification of novel key genes involved in non-alcoholic fatty liver disease.,2023,10.1038/s41598-023-46711-x,https://pubmed.ncbi.nlm.nih.gov/37993474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,39506873,The causal association between COVID-19 and ischemic stroke: a mendelian randomization study.,2024,10.1186/s12985-024-02548-y,https://pubmed.ncbi.nlm.nih.gov/39506873/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,35535313,Oncolytic Adenovirus with SPAG9 shRNA Driven by DD3 Promoter Improved the Efficacy of Docetaxil for Prostate Cancer.,2022,10.1155/2022/7918067,https://pubmed.ncbi.nlm.nih.gov/35535313/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,37357722,The bioceramic sealer iRoot SP promotes osteogenic differentiation of human stem cells from apical papilla via miR-141-3p/SPAG9/MAPK signalling pathway.,2023,10.1111/iej.13948,https://pubmed.ncbi.nlm.nih.gov/37357722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,35879405,The combination of ruxolitinib and Bcl-2/Mcl-1 inhibitors has a synergistic effect on leukemic cells carrying a SPAG9::JAK2 fusion.,2022,10.1038/s41417-022-00511-z,https://pubmed.ncbi.nlm.nih.gov/35879405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,39392357,Proteomic Characterization of Urinary Exosomes with Pancreatic Cancer by Phosphatidylserine Imprinted Polymer Enrichment and Mass Spectrometry Analysis.,2025,10.1021/acs.jproteome.4c00508,https://pubmed.ncbi.nlm.nih.gov/39392357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,31497238,SPAG9 promotes prostate cancer proliferation and metastasis via MAPK signaling pathway.,2019,,https://pubmed.ncbi.nlm.nih.gov/31497238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,34493268,"Dendritic cells matured with recombinant human sperm associated antigen 9 (rhSPAG9) induce CD4+, CD8+ T cells and activate NK cells: a potential candidate molecule for immunotherapy in cervical cancer.",2021,10.1186/s12935-021-01951-7,https://pubmed.ncbi.nlm.nih.gov/34493268/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,32776977,Sperm associated antigen 9 promotes oncogenic KSHV-encoded interferon regulatory factor-induced cellular transformation and angiogenesis by activating the JNK/VEGFA pathway.,2020,10.1371/journal.ppat.1008730,https://pubmed.ncbi.nlm.nih.gov/32776977/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,32503577,miR-874 inhibits gastric cancer cell proliferation by targeting SPAG9.,2020,10.1186/s12885-020-06994-z,https://pubmed.ncbi.nlm.nih.gov/32503577/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,23170277,Cancer testis antigens: A new paradigm for cancer therapy.,2012,10.4161/onci.20686,https://pubmed.ncbi.nlm.nih.gov/23170277/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,37251077,Exploring the shared gene signatures of smoking-related osteoporosis and chronic obstructive pulmonary disease using machine learning algorithms.,2023,10.3389/fmolb.2023.1204031,https://pubmed.ncbi.nlm.nih.gov/37251077/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,26893659,"SPAG9 controls the cell motility, invasion and angiogenesis of human osteosarcoma cells.",2016,10.3892/etm.2015.2932,https://pubmed.ncbi.nlm.nih.gov/26893659/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,21356354,Sperm-associated antigen 9 is a novel biomarker for colorectal cancer and is involved in tumor growth and tumorigenicity.,2011,10.1016/j.ajpath.2010.11.047,https://pubmed.ncbi.nlm.nih.gov/21356354/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,24349057,Sperm associated antigen 9 plays an important role in bladder transitional cell carcinoma.,2013,10.1371/journal.pone.0081348,https://pubmed.ncbi.nlm.nih.gov/24349057/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,36203482,Fertility-Sparing Approach in Patients with Endometrioid Endometrial Cancer Grade 2 Stage IA (FIGO): A Qualitative Systematic Review.,2022,10.1155/2022/4070368,https://pubmed.ncbi.nlm.nih.gov/36203482/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,20359745,Immunogenic antigens as therapeutic targets against myeloid leukaemic cells.,2010,10.1016/j.leukres.2010.03.013,https://pubmed.ncbi.nlm.nih.gov/20359745/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,20138665,Sperm associated antigen 9 expression and humoral response in chronic myeloid leukemia.,2010,10.1016/j.leukres.2010.01.017,https://pubmed.ncbi.nlm.nih.gov/20138665/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,29699331,Vaccines for immunological control of fertility.,2010,10.1007/s12522-009-0042-9,https://pubmed.ncbi.nlm.nih.gov/29699331/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,16112646,Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia.,2005,10.1016/j.bbrc.2005.08.024,https://pubmed.ncbi.nlm.nih.gov/16112646/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,14662895,A novel protein highly expressed in testis is overexpressed in systemic sclerosis fibroblasts and targeted by autoantibodies.,2003,10.4049/jimmunol.171.12.6883,https://pubmed.ncbi.nlm.nih.gov/14662895/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAG9,ENSG00000008294,Unsafe,9480848,"Cloning of a novel human testis mRNA specifically expressed in testicular haploid germ cells, having unique palindromic sequences and encoding a leucine zipper dimerization motif.",1998,10.1006/bbrc.1997.7943,https://pubmed.ncbi.nlm.nih.gov/9480848/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,42538614,SPG4 Hereditary Spastic Paraplegia: From Etiology to Therapy.,2026,10.1002/mds.70453,https://pubmed.ncbi.nlm.nih.gov/42538614/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,42658319,Significant differences in phenotype and age of onset in an SPG4 family caused by whole SPAST deletion combined with a hemizygous S44L modifier.,2026,10.1007/s10048-026-00931-1,https://pubmed.ncbi.nlm.nih.gov/42658319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,41739645,Modeling spastic paraplegia 4 with corticospinal motor neuron-enriched cortical organoids reveals genotype-phenotype and HDAC6-targetable pathology.,2026,10.1016/j.celrep.2026.117036,https://pubmed.ncbi.nlm.nih.gov/41739645/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,41885189,SPG4 and Dementia: Expanding the Clinical Spectrum.,2026,10.1002/acn3.70371,https://pubmed.ncbi.nlm.nih.gov/41885189/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,42521669,Alu-mediated SPAST deletion impairs golgi zinc transport and reveals a druggable vulnerability.,2026,10.1038/s41392-026-02785-3,https://pubmed.ncbi.nlm.nih.gov/42521669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,41748310,A GJA1 Variant Triggers Earlier SPG4 Onset by Destabilizing Deubiquitinase VCPIP1 to Lower SPASTIN Levels.,2026,10.1002/mds.70248,https://pubmed.ncbi.nlm.nih.gov/41748310/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,42687129,Validation of a Cellular Imaging-Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia.,2026,10.1002/acn3.70482,https://pubmed.ncbi.nlm.nih.gov/42687129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,42083457,Genotype-structure-phenotype correlations define divergent natural history in early-onset spastic paraplegia type 4.,2026,10.1093/brain/awag150,https://pubmed.ncbi.nlm.nih.gov/42083457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,41978773,Expanding the clinical and mutational spectrum of hereditary spastic paraplegia type 4 in a cohort of patients from central China.,2026,10.3389/fgene.2026.1800987,https://pubmed.ncbi.nlm.nih.gov/41978773/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,41311060,Intracerebroventricular SPAST-AAV9 gene therapy prevents manifestation of symptoms in a mouse model of SPG4 hereditary spastic paraplegia.,2026,10.1016/j.ymthe.2025.11.029,https://pubmed.ncbi.nlm.nih.gov/41311060/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,41797006,Spastin Is Required to Prevent SPAST-Related Demyelination.,2026,10.1111/jnc.70407,https://pubmed.ncbi.nlm.nih.gov/41797006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,42001173,Tissue-specific gene dosage disruption is a key feature and pathogenic mechanism of structural variants in the human genome.,2026,10.1186/s13073-026-01653-7,https://pubmed.ncbi.nlm.nih.gov/42001173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,41507865,Subclinical involvement of central nervous system structures other than motor or sensory tracts in SPG3A and SPG4 patients.,2026,10.1186/s12883-025-04624-4,https://pubmed.ncbi.nlm.nih.gov/41507865/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,41000004,Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics.,2026,10.1002/acn3.70206,https://pubmed.ncbi.nlm.nih.gov/41000004/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,40870017,Expanding the Phenotypic Spectrum of SPG4: Autism Spectrum Disorder in Early-Onset and Complex SPAST-HSP and Case Study.,2025,10.3390/genes16080970,https://pubmed.ncbi.nlm.nih.gov/40870017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,42065018,Spastic Quadriplegia Resulting From a Pathogenic Variant in the &lt;i&gt;SPAST&lt;/i&gt; Gene: A First Report.,2026,10.1155/crnm/2632593,https://pubmed.ncbi.nlm.nih.gov/42065018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,39614608,Unraveling Isoform Complexity: The Roles of M1- and M87-Spastin in Spastic Paraplegia 4 (SPG4).,2025,10.1002/mds.30072,https://pubmed.ncbi.nlm.nih.gov/39614608/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,41403389,Reversing Autophagy Inhibition Ameliorates Neurodegeneration in Hereditary Spastic Paraplegia Caused by a Degradation-Resistant SPAST Mutation.,2026,10.1002/mds.70150,https://pubmed.ncbi.nlm.nih.gov/41403389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,42320547,"Proteomic analysis reveals early pathological defects in corticospinal motor neurons of a spastin model of hereditary spastic paraplegia, which are improved by NU-9 treatment.",2026,10.1016/j.nbd.2026.107494,https://pubmed.ncbi.nlm.nih.gov/42320547/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,39731306,From spastic paraplegia to infantile neurodegenerative disorder: Expanding the phenotypic spectrum associated with biallelic SPAST variants.,2025,10.1111/ene.70025,https://pubmed.ncbi.nlm.nih.gov/39731306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,41734945,MDSGene Systematic Review of Common Forms of Dominant Hereditary Spastic Paraplegia: Novel Insights.,2026,10.1002/mdc3.70559,https://pubmed.ncbi.nlm.nih.gov/41734945/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,42233908,Dilated Cardiomyopathy in a Woman With SPG4-Associated Hereditary Spastic Paraplegia.,2026,10.1016/j.jaccas.2026.108746,https://pubmed.ncbi.nlm.nih.gov/42233908/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,41541044,Serendipitous Symptom Control: Allopurinol for Spasticity in a Case of SPG4-Linked Hereditary Spastic Paraplegia-A Case Report.,2026,10.1002/ccr3.71884,https://pubmed.ncbi.nlm.nih.gov/41541044/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,38066582,A novel truncated variant in SPAST results in spastin accumulation and defects in microtubule dynamics.,2023,10.1186/s12920-023-01759-6,https://pubmed.ncbi.nlm.nih.gov/38066582/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,39334479,Spastin accumulation and motor neuron defects caused by a novel SPAST splice site mutation.,2024,10.1186/s12967-024-05669-8,https://pubmed.ncbi.nlm.nih.gov/39334479/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,41774218,Beyond mobility: A prospective study on diet and metabolism in hereditary spastic paraplegia.,2026,10.1007/s11011-026-01815-x,https://pubmed.ncbi.nlm.nih.gov/41774218/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,40397864,The SpasT-SCI-T trial protocol: Investigating calpain-mediated sodium channel fragments as biomarkers for traumatic CNS injuries and spasticity prediction.,2025,10.1371/journal.pone.0319635,https://pubmed.ncbi.nlm.nih.gov/40397864/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,34439700,Therapeutic Strategies for Mutant SPAST-Based Hereditary Spastic Paraplegia.,2021,10.3390/brainsci11081081,https://pubmed.ncbi.nlm.nih.gov/34439700/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,35591986,Oral Vaccination of Mice With Trichinella spiralis Putative Serine Protease and Murine Interleukin-4 DNA Delivered by Invasive Lactiplantibacillus plantarum Elicits Protective Immunity.,2022,10.3389/fmicb.2022.859243,https://pubmed.ncbi.nlm.nih.gov/35591986/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,33708099,Coexistence of Hereditary Spastic Paraplegia Type 4 and Narcolepsy: A Case Report.,2021,10.1159/000512404,https://pubmed.ncbi.nlm.nih.gov/33708099/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,36580633,Effect of the Structure of Magnetic Nanocomposite Adsorbents on the Lysozyme Separation Efficiency.,2023,10.1021/acsabm.2c00833,https://pubmed.ncbi.nlm.nih.gov/36580633/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,37144097,Reduced acetylated α-tubulin in SPAST hereditary spastic paraplegia patient PBMCs.,2023,10.3389/fnins.2023.1073516,https://pubmed.ncbi.nlm.nih.gov/37144097/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,38651515,Relationship between brain white matter damage and grey matter atrophy in hereditary spastic paraplegia types 4 and 5.,2024,10.1111/ene.16310,https://pubmed.ncbi.nlm.nih.gov/38651515/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,41586880,Natural history in hereditary spastic paraplegias: real-world data from an Austrian cohort.,2026,10.1007/s00415-025-13606-y,https://pubmed.ncbi.nlm.nih.gov/41586880/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPAST,ENSG00000021574,Unsafe,10610178,"Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia.",1999,10.1038/15472,https://pubmed.ncbi.nlm.nih.gov/10610178/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA17,ENSG00000162814,Unsafe,41972556,The Molecular Characterization and Functional Analysis of &lt;i&gt;Pomacea canaliculata&lt;/i&gt; Boule: A Central Player in Spermatogenesis and Male Fertility.,2026,10.3390/biology15070554,https://pubmed.ncbi.nlm.nih.gov/41972556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA17,ENSG00000162814,Unsafe,39686771,Novel homozygous SPAG17 variants cause human male infertility through multiple morphological abnormalities of spermatozoal flagella related to axonemal microtubule doublets.,2025,10.4103/aja202496,https://pubmed.ncbi.nlm.nih.gov/39686771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA17,ENSG00000162814,Unsafe,38886667,DNA methylation patterns in patients with asthenospermia and oligoasthenospermia.,2024,10.1186/s12864-024-10491-z,https://pubmed.ncbi.nlm.nih.gov/38886667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA17,ENSG00000162814,Unsafe,38572922,Feature Engineering-Assisted Drug Repurposing on Disease-Drug Transcriptome Profiles in Gastric Cancer.,2024,10.1089/adt.2023.141,https://pubmed.ncbi.nlm.nih.gov/38572922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA17,ENSG00000162814,Unsafe,35384611,Comprehensive Transcriptome Analysis of Gonadal and Somatic Tissues for Identification of Sex-Related Genes in the Largemouth Bass Micropterus salmoides.,2022,10.1007/s10126-022-10127-x,https://pubmed.ncbi.nlm.nih.gov/35384611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA17,ENSG00000162814,Unsafe,23079716,Overexpression of human SPATA17 protein induces germ cell apoptosis in transgenic male mice.,2013,10.1007/s11033-012-2246-z,https://pubmed.ncbi.nlm.nih.gov/23079716/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA17,ENSG00000162814,Unsafe,21108043,Overexpression a novel zebra fish spermatogenesis-associated gene 17 (SPATA17) induces apoptosis in GC-1 cells.,2011,10.1007/s11033-010-0511-6,https://pubmed.ncbi.nlm.nih.gov/21108043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA17,ENSG00000162814,Unsafe,19483714,A single nucleotide polymorphism in SPATA17 may be a genetic risk factor for Japanese patients with meiotic arrest.,2009,10.1038/aja.2009.30,https://pubmed.ncbi.nlm.nih.gov/19483714/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA17,ENSG00000162814,Unsafe,25353171,Genetic analysis of intracapillary glomerular lipoprotein deposits in aging mice.,2014,10.1371/journal.pone.0111308,https://pubmed.ncbi.nlm.nih.gov/25353171/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA17,ENSG00000162814,Unsafe,16395525,Expression and identification of a novel apoptosis gene Spata17 (MSRG-11) in mouse spermatogenic cells.,2006,10.1111/j.1745-7270.2006.00125.x,https://pubmed.ncbi.nlm.nih.gov/16395525/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA17,ENSG00000162814,Unsafe,21901812,Effects of decabromodiphenyl ether (BDE-209) on mRNA transcription of thyroid hormone pathway and spermatogenesis associated genes in Chinese rare minnow (Gobiocypris rarus).,2014,10.1002/tox.20767,https://pubmed.ncbi.nlm.nih.gov/21901812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA17,ENSG00000162814,Unsafe,23549274,"De novo microduplications at 1q41, 2q37.3, and 8q24.3 in patients with VATER/VACTERL association.",2013,10.1038/ejhg.2013.58,https://pubmed.ncbi.nlm.nih.gov/23549274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA17,ENSG00000162814,Unsafe,27802063,In silico analysis of candidate proteins sharing homology with Streptococcus agalactiae proteins and their role in male infertility.,2017,10.1080/19396368.2016.1243741,https://pubmed.ncbi.nlm.nih.gov/27802063/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA17,ENSG00000162814,Unsafe,32163230,Whole exome sequencing identifies multiple novel candidate genes in familial gastroschisis.,2020,10.1002/mgg3.1176,https://pubmed.ncbi.nlm.nih.gov/32163230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,41637829,Comprehensive transcriptome analysis of somatic and gonadal tissues for identification of sex-biased genes in spotted scat (Scatophagus argus).,2026,10.1016/j.cbd.2026.101767,https://pubmed.ncbi.nlm.nih.gov/41637829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,40612294,Molecular characterization and expression of &lt;i&gt;Spata22&lt;/i&gt; in testes of the sterile male cattle-yak.,2025,10.1016/j.vas.2025.100471,https://pubmed.ncbi.nlm.nih.gov/40612294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,42098781,SPATA22 heterozygous variants drive premature ovarian insufficiency: mechanism of granulosa cells dysfunction and therapeutic potential of N-acetylcysteine (NAC) treatment.,2026,10.1186/s12958-026-01547-8,https://pubmed.ncbi.nlm.nih.gov/42098781/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,40296718,New feature of hMEIOB and hSPATA22 binding to ssDNA from a single-molecule perspective.,2025,10.3724/abbs.2025057,https://pubmed.ncbi.nlm.nih.gov/40296718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,40954385,A genome-wide association study identifies Asian-specific genetic susceptibility for epigenetic age acceleration.,2026,10.1007/s11357-025-01885-2,https://pubmed.ncbi.nlm.nih.gov/40954385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,42133574,ssDNA dynamics during mammalian meiotic recombination†.,2026,10.1093/biolre/ioag102,https://pubmed.ncbi.nlm.nih.gov/42133574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,32388826,shani mutation in mouse affects splicing of Spata22 and leads to impaired meiotic recombination.,2020,10.1007/s00412-020-00735-8,https://pubmed.ncbi.nlm.nih.gov/32388826/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,36331299,Nuclear localization of human MEIOB requires its NLS in the OB domain and interaction with SPATA22.,2022,10.3724/abbs.2022156,https://pubmed.ncbi.nlm.nih.gov/36331299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,32463099,A cell-based high-content screen identifies isocotoin as a small molecule inhibitor of the meiosis-specific MEIOB-SPATA22 complex†.,2020,10.1093/biolre/ioaa062,https://pubmed.ncbi.nlm.nih.gov/32463099/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,35384611,Comprehensive Transcriptome Analysis of Gonadal and Somatic Tissues for Identification of Sex-Related Genes in the Largemouth Bass Micropterus salmoides.,2022,10.1007/s10126-022-10127-x,https://pubmed.ncbi.nlm.nih.gov/35384611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,28297563,Spermatogenesis associated 22 is required for DNA repair and synapsis of homologous chromosomes in mouse germ cells.,2017,10.1111/andr.12315,https://pubmed.ncbi.nlm.nih.gov/28297563/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,33523351,Differential expression analysis and identification of sex-related genes by gonad transcriptome sequencing in estradiol-treated and non-treated Ussuri catfish Pseudobagrus ussuriensis.,2021,10.1007/s10695-021-00932-x,https://pubmed.ncbi.nlm.nih.gov/33523351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,28453612,Meiosis-specific proteins MEIOB and SPATA22 cooperatively associate with the single-stranded DNA-binding replication protein A complex and DNA double-strand breaks.,2017,10.1093/biolre/iox040,https://pubmed.ncbi.nlm.nih.gov/28453612/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,31000419,A truncating MEIOB mutation responsible for familial primary ovarian insufficiency abolishes its interaction with its partner SPATA22 and their recruitment to DNA double-strand breaks.,2019,10.1016/j.ebiom.2019.03.075,https://pubmed.ncbi.nlm.nih.gov/31000419/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,29635292,Comparative whole genome DNA methylation profiling of cattle sperm and somatic tissues reveals striking hypomethylated patterns in sperm.,2018,10.1093/gigascience/giy039,https://pubmed.ncbi.nlm.nih.gov/29635292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,34237181,Zebrafish intestinal transcriptome highlights subdued inflammatory responses to dietary soya bean and efficacy of yeast β-glucan.,2021,10.1111/jfd.13484,https://pubmed.ncbi.nlm.nih.gov/34237181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,23903057,Infertility associated with meiotic failure in the tremor rat (tm/tm) is caused by the deletion of spermatogenesis associated 22.,2013,10.1538/expanim.62.219,https://pubmed.ncbi.nlm.nih.gov/23903057/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,22011390,"Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells.",2012,10.1095/biolreprod.111.095752,https://pubmed.ncbi.nlm.nih.gov/22011390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,25142975,Genetic evidence suggests that Spata22 is required for the maintenance of Rad51 foci in mammalian meiosis.,2014,10.1038/srep06148,https://pubmed.ncbi.nlm.nih.gov/25142975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,30716097,Dual functions for the ssDNA-binding protein RPA in meiotic recombination.,2019,10.1371/journal.pgen.1007952,https://pubmed.ncbi.nlm.nih.gov/30716097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,34392356,Whole-exome sequencing of consanguineous families with infertile men and women identifies homologous mutations in SPATA22 and MEIOB.,2021,10.1093/humrep/deab185,https://pubmed.ncbi.nlm.nih.gov/34392356/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA22,ENSG00000141255,Unsafe,15713825,Novel development-related alternative splices in human testis identified by cDNA microarrays.,2005,10.1002/j.1939-4640.2005.tb01085.x,https://pubmed.ncbi.nlm.nih.gov/15713825/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA24,ENSG00000170469,Unsafe,40917356,Potential role of 4-hydroxyisoleucine in enhancing fertility in male mice with diet-induced obesity.,2025,10.3389/fendo.2025.1561543,https://pubmed.ncbi.nlm.nih.gov/40917356/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA24,ENSG00000170469,Unsafe,35709667,Mixed model-based eQTL analysis reveals lncRNAs associated with regulation of genes involved in sex determination and spermatogenesis: The key to understanding human gender imbalance.,2022,10.1016/j.compbiolchem.2022.107713,https://pubmed.ncbi.nlm.nih.gov/35709667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31G1,ENSG00000174038,Unsafe,36871790,C9orf131 and C10orf120 are not essential for male fertility in humans or mice.,2023,10.1016/j.ydbio.2023.02.009,https://pubmed.ncbi.nlm.nih.gov/36871790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA31G1,ENSG00000174038,Unsafe,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA33,ENSG00000167523,Unsafe,35536443,SPATA33 affects the formation of cell adhesion complex by interacting with CTNNA3 in TM4 cells.,2022,10.1007/s00441-022-03631-y,https://pubmed.ncbi.nlm.nih.gov/35536443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA33,ENSG00000167523,Unsafe,34446558,SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.,2021,10.1073/pnas.2106673118,https://pubmed.ncbi.nlm.nih.gov/34446558/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA33,ENSG00000167523,Unsafe,33087875,SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy.,2021,10.1038/s41418-020-00638-2,https://pubmed.ncbi.nlm.nih.gov/33087875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA33,ENSG00000167523,Unsafe,39316935,Divergent transcriptomic profiles in depressed individuals with hyper- and hypophagia implicating inflammatory status.,2024,10.1016/j.jpsychires.2024.09.020,https://pubmed.ncbi.nlm.nih.gov/39316935/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA33,ENSG00000167523,Unsafe,33818286,SPATA33 functions as a mitophagy receptor in mammalian germline.,2021,10.1080/15548627.2021.1909836,https://pubmed.ncbi.nlm.nih.gov/33818286/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA33,ENSG00000167523,Unsafe,40751759,Deciphering the molecular clock: exploring molecular mechanisms and genetic influences on skin ageing.,2025,10.1007/s10522-025-10296-x,https://pubmed.ncbi.nlm.nih.gov/40751759/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA33,ENSG00000167523,Unsafe,35886074,Further Insights on RNA Expression and Sperm Motility.,2022,10.3390/genes13071291,https://pubmed.ncbi.nlm.nih.gov/35886074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA33,ENSG00000167523,Unsafe,38111388,Genome-wide single nucleotide polymorphism (SNP) data reveal potential candidate genes for litter traits in a Yorkshire pig population.,2023,10.5194/aab-66-357-2023,https://pubmed.ncbi.nlm.nih.gov/38111388/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA33,ENSG00000167523,Unsafe,23844118,A novel testis-enriched gene Spata33 is expressed during spermatogenesis.,2013,10.1371/journal.pone.0067882,https://pubmed.ncbi.nlm.nih.gov/23844118/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA33,ENSG00000167523,Unsafe,30098056,Gene alterations and expression spectrum of SPATA33 in nonobstructive azoospermic Iranian men.,2018,10.1002/mrd.23051,https://pubmed.ncbi.nlm.nih.gov/30098056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA33,ENSG00000167523,Unsafe,36959629,DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight.,2023,10.1186/s13148-023-01463-3,https://pubmed.ncbi.nlm.nih.gov/36959629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA33,ENSG00000167523,Unsafe,36099812,Genetic landscape of a large cohort of Primary Ovarian Insufficiency: New genes and pathways and implications for personalized medicine.,2022,10.1016/j.ebiom.2022.104246,https://pubmed.ncbi.nlm.nih.gov/36099812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA33,ENSG00000167523,Unsafe,36035146,Novel genetic associations with five aesthetic facial traits: A genome-wide association study in the Chinese population.,2022,10.3389/fgene.2022.967684,https://pubmed.ncbi.nlm.nih.gov/36035146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA33,ENSG00000167523,Unsafe,37424101,Tethering ATG16L1 or LC3 induces targeted autophagic degradation of protein aggregates and mitochondria.,2023,10.1080/15548627.2023.2234797,https://pubmed.ncbi.nlm.nih.gov/37424101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA33,ENSG00000167523,Unsafe,31630191,Functional annotation of melanoma risk loci identifies novel susceptibility genes.,2020,10.1093/carcin/bgz173,https://pubmed.ncbi.nlm.nih.gov/31630191/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA33,ENSG00000167523,Unsafe,35973810,Sequencing of the ZMYND15 gene in a cohort of infertile Chinese men reveals novel mutations in patients with teratozoospermia.,2023,10.1136/jmg-2022-108727,https://pubmed.ncbi.nlm.nih.gov/35973810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,39253718,Transcriptome analysis of four types of gonadal tissues in largemouth bass (Micropterus salmoides) to reveal its sex-related genes.,2024,10.3389/fgene.2024.1459427,https://pubmed.ncbi.nlm.nih.gov/39253718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,36446526,Transcriptome analyses in infertile men reveal germ cell-specific expression and splicing patterns.,2023,10.26508/lsa.202201633,https://pubmed.ncbi.nlm.nih.gov/36446526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,35384611,Comprehensive Transcriptome Analysis of Gonadal and Somatic Tissues for Identification of Sex-Related Genes in the Largemouth Bass Micropterus salmoides.,2022,10.1007/s10126-022-10127-x,https://pubmed.ncbi.nlm.nih.gov/35384611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,33314576,SPATA4 improves aging-induced metabolic dysfunction through promotion of preadipocyte differentiation and adipose tissue expansion.,2021,10.1111/acel.13282,https://pubmed.ncbi.nlm.nih.gov/33314576/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,40247127,Epigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses.,2025,10.1038/s41380-025-03031-y,https://pubmed.ncbi.nlm.nih.gov/40247127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,34858332,Application of SNP in Genetic Sex Identification and Effect of Estradiol on Gene Expression of Sex-Related Genes in Strongylocentrotus intermedius.,2021,10.3389/fendo.2021.756530,https://pubmed.ncbi.nlm.nih.gov/34858332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,40628169,PANoptosis-driven molecular stratification in esophageal squamous cell carcinoma: A multi-omics prognostic model and FGFR-Targeted therapeutic validation.,2025,10.1016/j.compbiomed.2025.110688,https://pubmed.ncbi.nlm.nih.gov/40628169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,35145544,Identification of Key Genes Related to Postnatal Testicular Development Based on Transcriptomic Data of Testis in Hu Sheep.,2021,10.3389/fgene.2021.773695,https://pubmed.ncbi.nlm.nih.gov/35145544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,37350641,Histopathologic Features for Overall Survival in Merkel Cell Carcinoma: A Case Series with Intact Mismatch Repair Protein Expression.,2023,10.5146/tjpath.2023.01603,https://pubmed.ncbi.nlm.nih.gov/37350641/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,31838782,Increased DNA methylation in the spermatogenesis-associated (SPATA) genes correlates with infertility.,2020,10.1111/andr.12742,https://pubmed.ncbi.nlm.nih.gov/31838782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,26424010,SPATA4 Counteracts Etoposide-Induced Apoptosis via Modulating Bcl-2 Family Proteins in HeLa Cells.,2015,10.1248/bpb.b15-00117,https://pubmed.ncbi.nlm.nih.gov/26424010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,24146794,Spermatogenesis associated 4 promotes Sertoli cell proliferation modulated negatively by regulatory factor X1.,2013,10.1371/journal.pone.0075933,https://pubmed.ncbi.nlm.nih.gov/24146794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,17673952,Cloning and characterization of chicken SPATA4 gene and analysis of its specific expression.,2007,10.1007/s11010-007-9556-9,https://pubmed.ncbi.nlm.nih.gov/17673952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,21445983,Spata4 promotes osteoblast differentiation through Erk-activated Runx2 pathway.,2011,10.1002/jbmr.394,https://pubmed.ncbi.nlm.nih.gov/21445983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,16038605,Cloning and characterization of zebra fish SPATA4 gene and analysis of its gonad specific expression.,2005,10.1007/s10541-005-0163-7,https://pubmed.ncbi.nlm.nih.gov/16038605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,27861489,Characterizing Transcriptional Networks in Male Rainbow Darter (Etheostoma caeruleum) that Regulate Testis Development over a Complete Reproductive Cycle.,2016,10.1371/journal.pone.0164722,https://pubmed.ncbi.nlm.nih.gov/27861489/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,21901812,Effects of decabromodiphenyl ether (BDE-209) on mRNA transcription of thyroid hormone pathway and spermatogenesis associated genes in Chinese rare minnow (Gobiocypris rarus).,2014,10.1002/tox.20767,https://pubmed.ncbi.nlm.nih.gov/21901812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,15826498,Cloning and expression analysis of gonadogenesis-associated gene SPATA4 from rainbow trout (Oncorhynchus mykiss).,2005,10.5483/bmbrep.2005.38.2.206,https://pubmed.ncbi.nlm.nih.gov/15826498/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,15516739,Cloning and characterization of testis-specific spermatogenesis associated gene homologous to human SPATA4 in rat.,2004,10.1248/bpb.27.1867,https://pubmed.ncbi.nlm.nih.gov/15516739/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,16336790,Molecular cloning and bioinformatic analysis of SPATA4 gene.,2005,10.5483/bmbrep.2005.38.6.739,https://pubmed.ncbi.nlm.nih.gov/16336790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,23604077,Identification of cilia genes that affect cell-cycle progression using whole-genome transcriptome analysis in Chlamydomonas reinhardtti.,2013,10.1534/g3.113.006338,https://pubmed.ncbi.nlm.nih.gov/23604077/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA4,ENSG00000150628,Unsafe,15158438,Cloning of a full-length cDNA of human testis-specific spermatogenic cell apoptosis inhibitor TSARG2 as a candidate oncogene.,2004,10.1016/j.bbrc.2004.04.160,https://pubmed.ncbi.nlm.nih.gov/15158438/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA45,ENSG00000185523,Unsafe,38697008,Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice.,2024,10.1016/j.jri.2024.104252,https://pubmed.ncbi.nlm.nih.gov/38697008/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA45,ENSG00000185523,Unsafe,35751016,Ectopic expression of a combination of 5 genes detects high risk forms of T-cell acute lymphoblastic leukemia.,2022,10.1186/s12864-022-08688-1,https://pubmed.ncbi.nlm.nih.gov/35751016/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA46,ENSG00000171722,Unsafe,42254241,The influence of unhealthy lifestyle on semen quality: results from a cross-sectional study and Mendelian randomization analysis.,2026,10.1097/ms9.0000000000004982,https://pubmed.ncbi.nlm.nih.gov/42254241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA46,ENSG00000171722,Unsafe,37833923,Comprehensive Analysis of the Transcriptome-Wide m6A Methylome in Shaziling Pig Testicular Development.,2023,10.3390/ijms241914475,https://pubmed.ncbi.nlm.nih.gov/37833923/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA46,ENSG00000171722,Unsafe,33064378,USP26 deubiquitinates androgen receptor (AR) in the maintenance of sperm maturation and spermatogenesis through the androgen receptor signaling pathway.,2020,10.17219/acem/123355,https://pubmed.ncbi.nlm.nih.gov/33064378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA46,ENSG00000171722,Unsafe,27488028,"Deficiency of SPATA46, a Novel Nuclear Membrane Protein, Causes Subfertility in Male Mice.",2016,10.1095/biolreprod.116.140996,https://pubmed.ncbi.nlm.nih.gov/27488028/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA46,ENSG00000171722,Unsafe,35616329,Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice.,2022,10.1242/dev.200489,https://pubmed.ncbi.nlm.nih.gov/35616329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA46,ENSG00000171722,Unsafe,30701647,Nuclear envelope dynamics during mammalian spermatogenesis: new insights on male fertility.,2019,10.1111/brv.12498,https://pubmed.ncbi.nlm.nih.gov/30701647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA46,ENSG00000171722,Unsafe,31374971,Genome-Wide Scan for Runs of Homozygosity Identifies Candidate Genes in Three Pig Breeds.,2019,10.3390/ani9080518,https://pubmed.ncbi.nlm.nih.gov/31374971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA46,ENSG00000171722,Unsafe,32405957,Transcriptomic profiling of long non-coding RNAs in non-virus associated hepatocellular carcinoma.,2020,10.1007/s12013-020-00915-4,https://pubmed.ncbi.nlm.nih.gov/32405957/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,42791710,Transcriptomic Dynamics and ECM Remodeling During Postnatal Testicular Maturation in the Tianzhu White Yak.,2026,10.3390/ani16182853,https://pubmed.ncbi.nlm.nih.gov/42791710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,42375253,"&lt;i&gt;Chlorella vulgaris&lt;/i&gt; improves fertility in malnourished male rats by regulating the oxidative state, spermatogenesis, and inflammatory cytokines.",2026,10.5455/ovj.2026.v16.i1.59,https://pubmed.ncbi.nlm.nih.gov/42375253/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,41148541,Reproductive Dysfunction and Testicular Epigenetic Alterations in Male Rats with Experimental Amebiasis: Evaluation of SPATA6 Methylation and Therapeutic Outcomes.,2025,10.1007/s11686-025-01133-9,https://pubmed.ncbi.nlm.nih.gov/41148541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,42179785,Integrative Machine Learning Framework Revealing TRPM4-Associated Signatures and Identifying SPATA6 as a Potential Biomarker in Prostate Cancer.,2026,10.7150/jca.129356,https://pubmed.ncbi.nlm.nih.gov/42179785/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,40976895,Unraveling the Role of Perivascular Macrophages in Alzheimer's Disease: Insights from the Crosstalk between Immunometabolism and Ferroptosis.,2026,10.2174/011570159x417328250908080404,https://pubmed.ncbi.nlm.nih.gov/40976895/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,40095067,Loss of Cep135 causes oligoasthenoteratozoospermia and male infertility in mice.,2025,10.1007/s00018-025-05616-w,https://pubmed.ncbi.nlm.nih.gov/40095067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,38096624,Molecular characterization of SPATA6 and association of its SNPs with testicular size in sheep.,2024,10.1016/j.theriogenology.2023.12.008,https://pubmed.ncbi.nlm.nih.gov/38096624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,38454159,BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly.,2024,10.1038/s44319-024-00112-x,https://pubmed.ncbi.nlm.nih.gov/38454159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,38126872,Identification of CFAP52 as a novel diagnostic target of male infertility with defects of sperm head-tail connection and flagella development.,2023,10.7554/elife.92769,https://pubmed.ncbi.nlm.nih.gov/38126872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,39777350,Panel containing three serum microRNAs: a promising biomarker for early detection of bladder cancer.,2024,10.3389/fonc.2024.1470457,https://pubmed.ncbi.nlm.nih.gov/39777350/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,40919429,Genome-wide association study on dairy goat milk production traits using three models.,2025,10.3389/fgene.2025.1650836,https://pubmed.ncbi.nlm.nih.gov/40919429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,40346865,Downregulation of spermatogenesis-associated transcripts in the spermatozoa of idiopathic infertile men.,2026,10.1111/andr.70060,https://pubmed.ncbi.nlm.nih.gov/40346865/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,40711600,A missense mutation in TCFL5 is associated with male infertility due to oligoasthenoteratozoospermia.,2025,10.1007/s00438-025-02278-y,https://pubmed.ncbi.nlm.nih.gov/40711600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,41499646,Discovery of a Pathogenic NME5 Variant Underlying Acephalic Spermatozoa Syndrome: Unraveling a Novel Genotype-Phenotype Association in Male Infertility.,2026,10.1111/cge.70049,https://pubmed.ncbi.nlm.nih.gov/41499646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,36672807,Identification of Circular RNAs of Testis and Caput Epididymis and Prediction of Their Potential Functional Roles in Donkeys.,2022,10.3390/genes14010066,https://pubmed.ncbi.nlm.nih.gov/36672807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,33667862,"Effects of SPATA6 on proliferation, apoptosis and steroidogenesis of Hu sheep Leydig cells in vitro.",2021,10.1016/j.theriogenology.2021.02.011,https://pubmed.ncbi.nlm.nih.gov/33667862/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,39199980,Genome-Wide Analysis of Genetic Diversity and Selection Signatures in Zaobei Beef Cattle.,2024,10.3390/ani14162447,https://pubmed.ncbi.nlm.nih.gov/39199980/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,37398910,Sex blind: bridging the gap between drug exposure and sex-related gene expression in Danio rerio using next-generation sequencing (NGS) data and a literature review to find the missing links in pharmaceutical and environmental toxicology studies.,2023,10.3389/ftox.2023.1187302,https://pubmed.ncbi.nlm.nih.gov/37398910/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,38505001,Copy number variants selected during pig domestication inferred from whole genome resequencing.,2024,10.3389/fvets.2024.1364267,https://pubmed.ncbi.nlm.nih.gov/38505001/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,26464655,The role of spermatogenesis-associated protein 6 in testicular germ cell tumors.,2015,,https://pubmed.ncbi.nlm.nih.gov/26464655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA6,ENSG00000132122,Unsafe,29691636,Genome-wide association for testis weight in the diversity outbred mouse population.,2018,10.1007/s00335-018-9745-8,https://pubmed.ncbi.nlm.nih.gov/29691636/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA9,ENSG00000145757,Unsafe,42254241,The influence of unhealthy lifestyle on semen quality: results from a cross-sectional study and Mendelian randomization analysis.,2026,10.1097/ms9.0000000000004982,https://pubmed.ncbi.nlm.nih.gov/42254241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA9,ENSG00000145757,Unsafe,40295237,Causal relationships between gut microbiota and male reproductive inflammation and infertility: Insights from Mendelian randomization.,2025,10.1097/md.0000000000042323,https://pubmed.ncbi.nlm.nih.gov/40295237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA9,ENSG00000145757,Unsafe,36070248,Genome-wide association study of liver enzyme elevation in an extended cohort of rheumatoid arthritis patients starting low-dose methotrexate.,2022,10.2217/pgs-2022-0074,https://pubmed.ncbi.nlm.nih.gov/36070248/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA9,ENSG00000145757,Unsafe,36708065,Genome-wide Association Study of Methotrexate-Induced Liver Injury in Rheumatoid Arthritis Patients.,2023,10.1002/cpt.2858,https://pubmed.ncbi.nlm.nih.gov/36708065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA9,ENSG00000145757,Unsafe,32849829,Genome-Wide Association Study Using Individual Single-Nucleotide Polymorphisms and Haplotypes for Erythrocyte Traits in Alpine Merino Sheep.,2020,10.3389/fgene.2020.00848,https://pubmed.ncbi.nlm.nih.gov/32849829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA9,ENSG00000145757,Unsafe,21946350,Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.,2011,10.1038/ng.941,https://pubmed.ncbi.nlm.nih.gov/21946350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATA9,ENSG00000145757,Unsafe,12493713,"NYD-SP16, a novel gene associated with spermatogenesis of human testis.",2003,10.1095/biolreprod.102.004242,https://pubmed.ncbi.nlm.nih.gov/12493713/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,39272266,Novel Single-Nucleotide Polymorphisms (SNPs) and Genetic Studies of the Shadow of Prion Protein (SPRN) in Quails.,2024,10.3390/ani14172481,https://pubmed.ncbi.nlm.nih.gov/39272266/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,39765621,Novel Insertion/Deletion Polymorphisms and Genetic Studies of the Shadow of Prion Protein (SPRN) in Raccoon Dogs.,2024,10.3390/ani14243716,https://pubmed.ncbi.nlm.nih.gov/39765621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,38929426,First Report of Single Nucleotide Polymorphisms (SNPs) of the Leporine Shadow of Prion Protein Gene (SPRN) and Absence of Nonsynonymous SNPs in the Open Reading Frame (ORF) in Rabbits.,2024,10.3390/ani14121807,https://pubmed.ncbi.nlm.nih.gov/38929426/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,38891635,The First Genetic Characterization of the SPRN Gene in Pekin Ducks (Anas platyrhynchos domesticus).,2024,10.3390/ani14111588,https://pubmed.ncbi.nlm.nih.gov/38891635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,41123810,Differential gene expression in peripheral vascular smooth muscle cells of patients with peripheral artery disease.,2026,10.1007/s10157-025-02774-w,https://pubmed.ncbi.nlm.nih.gov/41123810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,40204637,The prion-family protein Doppel exerts a protective role during influenza virus infection.,2025,10.1093/jimmun/vkaf031,https://pubmed.ncbi.nlm.nih.gov/40204637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,38812560,Novel polymorphisms and genetic studies of the shadow of prion protein gene (SPRN) in pheasants.,2024,10.3389/fvets.2024.1399548,https://pubmed.ncbi.nlm.nih.gov/38812560/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,41170269,The Implementation of Faricimab in East Lancashire NHS Trust: Highlighting the Real-World Efficacy and Safety in Patients With Neovascular Age-Related Macular Degeneration.,2025,10.7759/cureus.93478,https://pubmed.ncbi.nlm.nih.gov/41170269/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,35632724,"Novel Polymorphisms and Genetic Characteristics of the Shadow of Prion Protein Gene (SPRN) in Cats, Hosts of Feline Spongiform Encephalopathy.",2022,10.3390/v14050981,https://pubmed.ncbi.nlm.nih.gov/35632724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,35799279,Potential genetic robustness of Prnp and Sprn double knockout mouse embryos towards ShRNA-lentiviral inoculation.,2022,10.1186/s13567-022-01075-4,https://pubmed.ncbi.nlm.nih.gov/35799279/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,35151978,Post-transcriptional silencing of Bos taurus prion family genes and its impact on granulosa cell steroidogenesis.,2022,10.1016/j.bbrc.2022.02.012,https://pubmed.ncbi.nlm.nih.gov/35151978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,35982928,"Novel insertion/deletion polymorphisms and genetic features of the shadow of prion protein gene (SPRN) in dogs, a prion-resistant animal.",2022,10.3389/fvets.2022.942289,https://pubmed.ncbi.nlm.nih.gov/35982928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,34573540,"The First Report of Genetic Polymorphisms of the Equine SPRN Gene in Outbred Horses, Jeju and Halla Horses.",2021,10.3390/ani11092574,https://pubmed.ncbi.nlm.nih.gov/34573540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,35782543,"The First Report of Polymorphisms and Genetic Characteristics of the Shadow of Prion Protein (SPRN) in Prion Disease-Resistant Animal, Chickens.",2022,10.3389/fvets.2022.904305,https://pubmed.ncbi.nlm.nih.gov/35782543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,32943703,Polymorphisms of shadow of prion protein gene (SPRN) in Korean native cattle (Hanwoo) and Holstein cattle.,2020,10.1038/s41598-020-72225-x,https://pubmed.ncbi.nlm.nih.gov/32943703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,37286946,Multi-omics analysis reveals changes in tryptophan and cholesterol metabolism before and after sexual maturation in captive macaques.,2023,10.1186/s12864-023-09404-3,https://pubmed.ncbi.nlm.nih.gov/37286946/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,32317725,The Prion-like protein Shadoo is involved in mouse embryonic and mammary development and differentiation.,2020,10.1038/s41598-020-63805-y,https://pubmed.ncbi.nlm.nih.gov/32317725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,35709667,Mixed model-based eQTL analysis reveals lncRNAs associated with regulation of genes involved in sex determination and spermatogenesis: The key to understanding human gender imbalance.,2022,10.1016/j.compbiolchem.2022.107713,https://pubmed.ncbi.nlm.nih.gov/35709667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,31905681,"The First Report of Genetic and Structural Diversities in the SPRN Gene in the Horse, an Animal Resistant to Prion Disease.",2019,10.3390/genes11010039,https://pubmed.ncbi.nlm.nih.gov/31905681/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,31649311,Scrapie susceptibility-associated indel polymorphism of shadow of prion protein gene (SPRN) in Korean native black goats.,2019,10.1038/s41598-019-51625-8,https://pubmed.ncbi.nlm.nih.gov/31649311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,42611868,A strengthened soft-point registration network for LiDAR point cloud registration.,2026,10.1371/journal.pone.0355292,https://pubmed.ncbi.nlm.nih.gov/42611868/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,35869782,A Modified Ultra-Sensitive ELISA for Measurement of LH in Mice.,2022,10.1210/endocr/bqac109,https://pubmed.ncbi.nlm.nih.gov/35869782/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,30779607,The Special Pathogens Research Network: Enabling Research Readiness.,2019,10.1089/hs.2018.0106,https://pubmed.ncbi.nlm.nih.gov/30779607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,35077391,Novel necroptosis-related gene signature for predicting the prognosis of pancreatic adenocarcinoma.,2022,10.18632/aging.203846,https://pubmed.ncbi.nlm.nih.gov/35077391/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,27561286,Utilisation of cardiac pacemakers over a 20-year period: Results from a nationwide pacemaker registry.,2017,10.1007/s12471-016-0880-0,https://pubmed.ncbi.nlm.nih.gov/27561286/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,30512033,Genomic Analysis and Prediction within a US Public Collaborative Winter Wheat Regional Testing Nursery.,2018,10.3835/plantgenome2018.01.0004,https://pubmed.ncbi.nlm.nih.gov/30512033/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,25364761,Role of the prion protein family in the gonads.,2014,10.3389/fcell.2014.00056,https://pubmed.ncbi.nlm.nih.gov/25364761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,19657386,Frequent missense and insertion/deletion polymorphisms in the ovine Shadoo gene parallel species-specific variation in PrP.,2009,10.1371/journal.pone.0006538,https://pubmed.ncbi.nlm.nih.gov/19657386/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,23071594,Comparative analysis of the Shadoo gene between cattle and buffalo reveals significant differences.,2012,10.1371/journal.pone.0046601,https://pubmed.ncbi.nlm.nih.gov/23071594/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,17703189,The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections.,2007,10.1038/sj.emboj.7601830,https://pubmed.ncbi.nlm.nih.gov/17703189/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,22114562,Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation.,2011,10.1371/journal.ppat.1002391,https://pubmed.ncbi.nlm.nih.gov/22114562/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,19798432,Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones.,2009,10.1371/journal.ppat.1000608,https://pubmed.ncbi.nlm.nih.gov/19798432/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPATC1,ENSG00000186583,Unsafe,20542897,Speriolin is a novel human and mouse sperm centrosome protein.,2010,10.1093/humrep/deq138,https://pubmed.ncbi.nlm.nih.gov/20542897/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,42012696,SPC25 promotes gastric cancer cells G1/S cell cycle transition and tumorigenesis by enhancing SLC1A5-mediated glutamine metabolism.,2026,10.1007/s10863-026-10108-y,https://pubmed.ncbi.nlm.nih.gov/42012696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,41801295,"A plant alkaloid lycorine inhibits non-small cell lung cancer cell proliferation, metastasis, glycolysis and promotes ferroptosis through the ZNF143/SPC25 axis.",2026,10.1007/s11418-025-01966-8,https://pubmed.ncbi.nlm.nih.gov/41801295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,40691691,SPC25 as a prognostic and immune-related biomarker in lung adenocarcinoma.,2025,10.1038/s41598-025-09615-6,https://pubmed.ncbi.nlm.nih.gov/40691691/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,41375045,Integrating Functional Genomic Screens and Multi-Omics Data to Construct a Prognostic Model for Lung Adenocarcinoma and Validating SPC25.,2025,10.3390/cancers17233844,https://pubmed.ncbi.nlm.nih.gov/41375045/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,41079598,Comparative bioinformatics analysis of the Wnt pathway in breast cancer: Selection of novel biomarker panels associated with ER status.,2025,10.1515/biol-2025-1173,https://pubmed.ncbi.nlm.nih.gov/41079598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,40552366,TFDP1 activates SPC25-mediated glutamine metabolism to repress anti-tumor immunity of NK cells in lung adenocarcinoma.,2025,10.1080/1744666x.2025.2524469,https://pubmed.ncbi.nlm.nih.gov/40552366/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,39948743,Mefloquine Suppresses Metastasis in Renal Cell Carcinoma Through Targeting SPC25.,2025,10.1111/cas.70001,https://pubmed.ncbi.nlm.nih.gov/39948743/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,40400636,The multifaceted functions of SPC25 in cancer: from molecular pathways to targeted therapy.,2025,10.3389/fmed.2025.1550901,https://pubmed.ncbi.nlm.nih.gov/40400636/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,39558547,SPC25 Activates the Warburg Effect to Inhibit Ferroptosis in Prostate Cancer Cells.,2024,10.1177/15579883241297880,https://pubmed.ncbi.nlm.nih.gov/39558547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,39919356,SPC25 upregulates CCND1 to promote the progression of esophageal squamous cell carcinoma by inhibiting MDM2-mediated E2F1 ubiquitination.,2025,10.1016/j.tranon.2025.102300,https://pubmed.ncbi.nlm.nih.gov/39919356/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,42035708,Genotoxic effects of 6PPD-quinone on juvenile European seabass (Dicentrarchus labrax): Impacts on DNA replication fidelity and oxidative DNA damage.,2026,10.1016/j.aquatox.2026.107830,https://pubmed.ncbi.nlm.nih.gov/42035708/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,39829079,Mechanism Study of E2F8 Activation of SPC25-Mediated Glutamine Metabolism Promoting Immune Escape in Lung Adenocarcinoma.,2025,10.1111/imm.13894,https://pubmed.ncbi.nlm.nih.gov/39829079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,38605119,Spindle component 25 predicts the prognosis and the immunotherapy response of cancers: a pan-cancer analysis.,2024,10.1038/s41598-024-59038-y,https://pubmed.ncbi.nlm.nih.gov/38605119/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,39488790,Targeting the SPC25/RIOK1/MYH9 Axis to Overcome Tumor Stemness and Platinum Resistance in Epithelial Ovarian Cancer.,2024,10.1002/advs.202406688,https://pubmed.ncbi.nlm.nih.gov/39488790/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,39755832,"Berberine restrains non-small cell lung cancer cell growth, invasion and glycolysis via inactivating the SPC25/NUF2 pathway.",2025,10.1007/s00210-024-03729-w,https://pubmed.ncbi.nlm.nih.gov/39755832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,39457969,"Effects of Substituting Fishmeal with Soy Protein Concentrate Supplemented with Essential Amino Acids in the Olive Flounder (Paralichthys olivaceus) Diet on the Expression of Genes Related to Growth, Stress, Immunity, and Digestive Enzyme.",2024,10.3390/ani14203039,https://pubmed.ncbi.nlm.nih.gov/39457969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,38217547,"SPC25 as a novel therapeutic and prognostic biomarker and its association with glycolysis, ferroptosis and ceRNA in lung adenocarcinoma.",2024,10.18632/aging.205418,https://pubmed.ncbi.nlm.nih.gov/38217547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,40546347,Network-based analysis of candidate oncogenes and pathways in hepatocellular carcinoma.,2025,10.1016/j.bbrep.2025.102086,https://pubmed.ncbi.nlm.nih.gov/40546347/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,38420826,"SPC25 Functions as a Prognostic-Related Biomarker, and Its High Expression Correlates with Tumor Immune Infiltration and UCEC Progression.",2024,10.31083/j.fbl2902069,https://pubmed.ncbi.nlm.nih.gov/38420826/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,39061878,"Excessive Replacement of Fish Meal by Soy Protein Concentrate Resulted in Inhibition of Growth, Nutrient Metabolism, Antioxidant Capacity, Immune Capacity, and Intestinal Development in Juvenile Largemouth Bass (Micropterus salmoides).",2024,10.3390/antiox13070809,https://pubmed.ncbi.nlm.nih.gov/39061878/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,40792151,Identification and validation of hub genes for kidney renal clear cell carcinoma treated with metformin and everolimus combination therapy.,2025,10.21037/tcr-2025-277,https://pubmed.ncbi.nlm.nih.gov/40792151/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,40399988,Exploring the genomic and transcriptomic profiles of glycemic traits and drug repurposing.,2025,10.1186/s12929-025-01137-7,https://pubmed.ncbi.nlm.nih.gov/40399988/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,38324016,Coregulation of NDC80 Complex Subunits Determines the Fidelity of the Spindle-Assembly Checkpoint and Mitosis.,2024,10.1158/1541-7786.mcr-23-0828,https://pubmed.ncbi.nlm.nih.gov/38324016/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,35967419,Spindle pole body component 25 and platelet-derived growth factor mediate crosstalk between tumor-associated macrophages and prostate cancer cells.,2022,10.3389/fimmu.2022.907636,https://pubmed.ncbi.nlm.nih.gov/35967419/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,33408271,SPC25 overexpression promotes tumor proliferation and is prognostic of poor survival in hepatocellular carcinoma.,2020,10.18632/aging.202329,https://pubmed.ncbi.nlm.nih.gov/33408271/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,37059592,Cellular senescence-related gene signature as a valuable predictor of prognosis in hepatocellular carcinoma.,2023,10.18632/aging.204658,https://pubmed.ncbi.nlm.nih.gov/37059592/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,31400751,Up-regulation of SPC25 promotes breast cancer.,2019,10.18632/aging.102153,https://pubmed.ncbi.nlm.nih.gov/31400751/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPC25,ENSG00000152253,Unsafe,39323031,Comprehensive Analysis Identifies Hyaluronan Mediated Motility Receptor and Cell Division Cycle 25C as Potential Prognostic Biomarkers in Head and Neck Squamous Cell Carcinoma.,2024,10.1177/10732748241287904,https://pubmed.ncbi.nlm.nih.gov/39323031/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,42769070,A homozygous &lt;i&gt;SPDYA&lt;/i&gt; variant associated with meiotic arrest and failed microdissection testicular sperm extraction in non-obstructive azoospermia.,2026,10.3389/fendo.2026.1916743,https://pubmed.ncbi.nlm.nih.gov/42769070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,41483811,Atypical cell cycle regulation over neural stem cell expansion.,2026,10.1016/j.stemcr.2025.102752,https://pubmed.ncbi.nlm.nih.gov/41483811/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,42417195,Cap 2'-O-methyltransferase CMTR2 regulates male meiosis independent of its methyltransferase activity.,2026,10.1093/nar/gkag699,https://pubmed.ncbi.nlm.nih.gov/42417195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,42658044,The non-canonical CDK2 activator SPY1 uses separable mechanisms to activate phosphorylated and unphosphorylated CDK2.,2026,10.1042/bcj20260441,https://pubmed.ncbi.nlm.nih.gov/42658044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,40826181,Speedy A governs non-homologous XY chromosome desynapsis as a unique prerequisite for XY loop-axis organization.,2025,10.1038/s44318-025-00528-8,https://pubmed.ncbi.nlm.nih.gov/40826181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,41793107,Systematic Multiplatform Discovery of Methylation Markers Enables Non-Invasive Early Detection of Endometrial Cancer.,2026,10.1111/cas.70346,https://pubmed.ncbi.nlm.nih.gov/41793107/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,40034037,Targeting cyclin-dependent kinase 2 (CDK2) interactions with cyclins and Speedy 1 (Spy1) for cancer and male contraception.,2025,10.1080/17568919.2025.2463868,https://pubmed.ncbi.nlm.nih.gov/40034037/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,38943151,Atypical cell cycle regulation promotes mammary stem cell expansion during mammary development and tumourigenesis.,2024,10.1186/s13058-024-01862-1,https://pubmed.ncbi.nlm.nih.gov/38943151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,42346934,Radiomics-Guided Multi-Sequence Learning for Pathological Complete Response Prediction from Breast MRI with Missing Auxiliary Sequences.,2026,10.3390/jimaging12060271,https://pubmed.ncbi.nlm.nih.gov/42346934/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,41094188,Multiscale Pancancer Analysis Uncovers Intrinsic Imaging and Molecular Characteristics Prominent in Breast Cancer and Glioblastoma.,2026,10.1038/s41416-025-03235-7,https://pubmed.ncbi.nlm.nih.gov/41094188/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,41540040,"BreastDCEDL: A standardized deep learning-ready breast DCE-MRI dataset of 2,070 patients.",2026,10.1038/s41597-026-06589-6,https://pubmed.ncbi.nlm.nih.gov/41540040/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,37588169,IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells.,2023,10.1016/j.isci.2023.107464,https://pubmed.ncbi.nlm.nih.gov/37588169/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,36876138,The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells.,2023,10.1016/j.isci.2023.106202,https://pubmed.ncbi.nlm.nih.gov/36876138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,36443440,SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1.,2023,10.1038/s41418-022-01089-7,https://pubmed.ncbi.nlm.nih.gov/36443440/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,40639694,Study on TGF beta polymorphism in psoriatic patients with plaques infected with Streptococcuspyogenes.,2025,10.1016/j.micpath.2025.107830,https://pubmed.ncbi.nlm.nih.gov/40639694/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,34039995,The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.,2021,10.1038/s41467-021-23550-w,https://pubmed.ncbi.nlm.nih.gov/34039995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,34954527,"Analysis and gonadal localization of Speedy A mRNA transcript, a novel gene associated with early germline cells in the scallop, Argopecten purpuratus.",2022,10.1016/j.anireprosci.2021.106909,https://pubmed.ncbi.nlm.nih.gov/34954527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,39500896,Genomic variations associated with risk and protection against vincristine-induced peripheral neuropathy in pediatric cancer patients.,2024,10.1038/s41525-024-00443-7,https://pubmed.ncbi.nlm.nih.gov/39500896/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,39429662,Phosphorus Metabolism-Related Genes Serve as Novel Biomarkers for Predicting Prognosis in Bladder Cancer: A Bioinformatics Analysis.,2024,10.18502/ijph.v53i9.16449,https://pubmed.ncbi.nlm.nih.gov/39429662/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,39244594,Multicenter radio-multiomic analysis for predicting breast cancer outcome and unravelling imaging-biological connection.,2024,10.1038/s41698-024-00666-y,https://pubmed.ncbi.nlm.nih.gov/39244594/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,42688134,BCMM: gated bidirectional cross-attention fusion of breast MRI and clinical features for predicting RCB response in the I-SPY1 cohort.,2026,10.3389/frai.2026.1846986,https://pubmed.ncbi.nlm.nih.gov/42688134/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,40771390,The value of multiparametric MRI-based combined intratumoral and peritumoral radiomics in differentiating luminal and non-luminal molecular subtypes of breast cancer: a multicenter study.,2025,10.21037/gs-2025-83,https://pubmed.ncbi.nlm.nih.gov/40771390/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,40584836,Development and validation of an MRI spatiotemporal interaction model for early noninvasive prediction of neoadjuvant chemotherapy response in breast cancer: a multicentre study.,2025,10.1016/j.eclinm.2025.103298,https://pubmed.ncbi.nlm.nih.gov/40584836/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,30116243,Protective Regulatory T Cell Immune Response Induced by Intranasal Immunization With the Live-Attenuated Pneumococcal Vaccine SPY1 via the Transforming Growth Factor-β1-Smad2/3 Pathway.,2018,10.3389/fimmu.2018.01754,https://pubmed.ncbi.nlm.nih.gov/30116243/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,37226243,Integration of multiomics data shows down regulation of mismatch repair and tubulin pathways in triple-negative chemotherapy-resistant breast tumors.,2023,10.1186/s13058-023-01656-x,https://pubmed.ncbi.nlm.nih.gov/37226243/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,35871247,Expert tumor annotations and radiomics for locally advanced breast cancer in DCE-MRI for ACRIN 6657/I-SPY1.,2022,10.1038/s41597-022-01555-4,https://pubmed.ncbi.nlm.nih.gov/35871247/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,36513760,Resampling and harmonization for mitigation of heterogeneity in image parameters of baseline scans.,2022,10.1038/s41598-022-26083-4,https://pubmed.ncbi.nlm.nih.gov/36513760/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,28956354,Heterologous prime-boost immunization with live SPY1 and DnaJ protein of Streptococcus pneumoniae induces strong Th1 and Th17 cellular immune responses in mice.,2017,10.1007/s12275-017-7262-1,https://pubmed.ncbi.nlm.nih.gov/28956354/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,28423577,"The cyclin-like protein, SPY1, regulates the ERα and ERK1/2 pathways promoting tamoxifen resistance.",2017,10.18632/oncotarget.15578,https://pubmed.ncbi.nlm.nih.gov/28423577/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,37270540,Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding.,2023,10.1038/s41467-023-38732-x,https://pubmed.ncbi.nlm.nih.gov/37270540/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,15611625,Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.,2005,10.4161/cc.4.1.1347,https://pubmed.ncbi.nlm.nih.gov/15611625/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPDYA,ENSG00000163806,Unsafe,11980914,Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2.,2002,10.1083/jcb.200109045,https://pubmed.ncbi.nlm.nih.gov/11980914/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,42748167,Coronavirus Nsp5‑mediated dual‑site cleavage of GSDMA modifies its antiviral and proinflammatory functions.,2026,10.1371/journal.ppat.1014602,https://pubmed.ncbi.nlm.nih.gov/42748167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,42604562,"Rotavirus-NSP5 interacts with and hijacks host ATP citrate lyase to viroplasms, enhancing lipid biosynthesis for facilitating rotavirus infection.",2026,10.1080/21505594.2026.2709258,https://pubmed.ncbi.nlm.nih.gov/42604562/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,42294686,Swine acute diarrhea syndrome coronavirus nsp5 induces apoptosis by targeting GATA zinc finger domain-containing protein 2A (GATAD2A/p66α).,2026,10.1128/mbio.00785-26,https://pubmed.ncbi.nlm.nih.gov/42294686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,39397181,SPECC1 as a pan-cancer biomarker: unraveling its role in drug sensitivity and resistance mechanisms.,2024,10.1007/s12672-024-01426-x,https://pubmed.ncbi.nlm.nih.gov/39397181/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,42466866,"Correction for Li et al., ""PDCoV NSP5 cleaves the selective autophagy receptor CCDC50 to disrupt autophagic degradation of the viral envelope protein"".",2026,10.1128/mbio.01535-26,https://pubmed.ncbi.nlm.nih.gov/42466866/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,42192130,Phosphorylation tunes strain-specific protein condensation during rotavirus replication organelle assembly.,2026,10.1038/s44318-026-00814-z,https://pubmed.ncbi.nlm.nih.gov/42192130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,42620616,PRRSV suppresses ER-phagy through Nsp2- and Nsp5-mediated degradation of FAM134B.,2026,10.3389/fcimb.2026.1905056,https://pubmed.ncbi.nlm.nih.gov/42620616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,42283626,Cleavage of TOM1 by the SARS-CoV-2 main protease NSP5 prevents autophagic degradation of viral envelope.,2026,10.1128/jvi.00434-26,https://pubmed.ncbi.nlm.nih.gov/42283626/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,41817175,PDCoV NSP5 cleaves the selective autophagy receptor CCDC50 to disrupt autophagic degradation of the viral envelope protein.,2026,10.1128/mbio.00259-26,https://pubmed.ncbi.nlm.nih.gov/41817175/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,39831223,Circular RNA SPECC1 promoted tumorigenesis and osimertinib resistance in lung adenocarcinoma via a circular RNA-microRNA network.,2024,10.21037/jtd-2024-2144,https://pubmed.ncbi.nlm.nih.gov/39831223/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,41102826,PRRSV NSP5 orchestrates dual immune disruption by targeting NLRP3 and STING.,2025,10.1186/s13567-025-01636-3,https://pubmed.ncbi.nlm.nih.gov/41102826/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,41924271,Cellular sensor DAP5 decodes &lt;i&gt;Betacoronaviral&lt;/i&gt; NSP5 to drive virus-induced senescence.,2026,10.3389/fimmu.2026.1768183,https://pubmed.ncbi.nlm.nih.gov/41924271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,41673661,Cell type resolved MR based on brain single cell eQTLs corroborated by single cell RNA sequencing uncovers neuroimmune and vascular programs in intracerebral hemorrhage.,2026,10.1186/s12967-026-07842-7,https://pubmed.ncbi.nlm.nih.gov/41673661/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,41866037,Cleavage at the nsp5-nsp6 site of SARS-CoV-2 main protease intermediate precursor is faster from a monomer than a dimer form.,2026,10.1016/j.jbc.2026.111395,https://pubmed.ncbi.nlm.nih.gov/41866037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,39333871,A novel protein SPECC1-415aa encoded by N6-methyladenosine modified circSPECC1 regulates the sensitivity of glioblastoma to TMZ.,2024,10.1186/s11658-024-00644-z,https://pubmed.ncbi.nlm.nih.gov/39333871/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,42287953,Identification of SARS-CoV-2 proteins suppressing host protein synthesis.,2026,10.1016/j.virol.2026.111006,https://pubmed.ncbi.nlm.nih.gov/42287953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,41758870,PRRSV-2 impedes lysosomes from eliminating secondary infected bacteria.,2026,10.1371/journal.ppat.1014000,https://pubmed.ncbi.nlm.nih.gov/41758870/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,41085289,Comparative analysis of NSP5/VP2-induced viroplasm-like structures in rotavirus species A to J.,2025,10.1128/jvi.00990-25,https://pubmed.ncbi.nlm.nih.gov/41085289/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,40736574,The P132H mutation of SARS-CoV-2 NSP5 relieves its inhibition on interferon-β activation via blocking MAVS degradation.,2025,10.1007/s00018-025-05822-6,https://pubmed.ncbi.nlm.nih.gov/40736574/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,40611336,Porcine reproductive and respiratory syndrome virus NSP5 exploited UBE2L6 to promote viral replication via antagonising host RLRs and ISGylation.,2025,10.1186/s13567-025-01558-0,https://pubmed.ncbi.nlm.nih.gov/40611336/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,40195509,Immunoinformatics-driven design of a multi-epitope vaccine targeting neonatal rotavirus with focus on outer capsid proteins VP4 and VP7 and non structural proteins NSP2 and NSP5.,2025,10.1038/s41598-025-95256-8,https://pubmed.ncbi.nlm.nih.gov/40195509/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,42097490,CircSPECC1 attenuates sensitivity to PD-1 blockade through impaired antigen presentation in hepatocellular carcinoma.,2026,10.1016/j.canlet.2026.218568,https://pubmed.ncbi.nlm.nih.gov/42097490/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,42412727,A rotavirus vaccine candidate attenuated by codon deoptimization protects neonatal mice against wild-type virus infection.,2026,10.1371/journal.ppat.1014292,https://pubmed.ncbi.nlm.nih.gov/42412727/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,40668805,Protracted SARS-CoV-2 Infection in B-cell Depleted Patients: Immunologic and Viral Characteristics and Response to Dual and Extended Antiviral Therapy.,2026,10.1093/cid/ciaf383,https://pubmed.ncbi.nlm.nih.gov/40668805/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,41519377,"Genomic and antigenic analysis of G1P[8] rotavirus strains in Ningxia, China.",2026,10.1016/j.ijid.2026.108372,https://pubmed.ncbi.nlm.nih.gov/41519377/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,40842188,PRRSV evades innate immune cGAS-STING antiviral function via its Nsp5 to deter STING translocation and activation.,2025,10.1080/21505594.2025.2548625,https://pubmed.ncbi.nlm.nih.gov/40842188/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,42655636,Human Coronavirus Photodynamic Inactivation and In Silico Mechanisms Induced by Ga(III) vs. Zn(II) Phthalocyanines.,2026,10.3390/v18080815,https://pubmed.ncbi.nlm.nih.gov/42655636/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,42436145,"Super-resolution atlas of SARS-CoV-2 infection reveals protease-dependent organelle maturation, dsRNA landscapes, and intracellular structural proteins.",2026,10.1038/s41467-026-75289-x,https://pubmed.ncbi.nlm.nih.gov/42436145/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,37600784,An attenuated herpesvirus vectored vaccine candidate induces T-cell responses against highly conserved porcine reproductive and respiratory syndrome virus M and NSP5 proteins that are unable to control infection.,2023,10.3389/fimmu.2023.1201973,https://pubmed.ncbi.nlm.nih.gov/37600784/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,42514641,Molecular Epidemiological Survey of Porcine Rotavirus in the Guangxi Region from 2020 to 2025 and Isolation and Identification of the G9P[23] Strain CH-GXGL-PoRV-3151-2021.,2026,10.3390/vetsci13070631,https://pubmed.ncbi.nlm.nih.gov/42514641/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,39480086,"PF-00835231 broadly inhibits swine Alpha-coronavirus, including emerging SADS-CoV.",2024,10.1128/jvi.01303-24,https://pubmed.ncbi.nlm.nih.gov/39480086/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,40479048,Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease.,2025,10.1126/sciadv.adv8875,https://pubmed.ncbi.nlm.nih.gov/40479048/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,42794799,"HPLC-HRMS/MS Characterization, Molecular Docking, and Comparative Genotoxicity of Free and Liposome-Encapsulated &lt;i&gt;Aesculus hippocastanum&lt;/i&gt; Seed Extract.",2026,10.3390/ijms27188372,https://pubmed.ncbi.nlm.nih.gov/42794799/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,38803355,"CircRNA regulates the liquid-liquid phase separation of ATG4B, a novel strategy to inhibit cancer metastasis?",2024,10.15698/cst2024.05.296,https://pubmed.ncbi.nlm.nih.gov/38803355/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPECC1,ENSG00000128487,Unsafe,15602574,A gene highly expressed in tumor cells encodes novel structure proteins.,2004,10.1038/sj.onc.1207988,https://pubmed.ncbi.nlm.nih.gov/15602574/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,42117808,A Novel Circular RNA circSPEF2 Regulates Testis Development in Crucian Carp.,2026,10.3390/biology15090669,https://pubmed.ncbi.nlm.nih.gov/42117808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,40747466,&lt;i&gt;SPEF1&lt;/i&gt; and &lt;i&gt;SPEF2&lt;/i&gt; as potential biomarkers in bladder cancer: Insights from a comprehensive bioinformatic analysis.,2025,10.14440/bladder.2024.0071,https://pubmed.ncbi.nlm.nih.gov/40747466/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,38568462,Novel SPEF2 variants cause male infertility and likely primary ciliary dyskinesia.,2024,10.1007/s10815-024-03106-9,https://pubmed.ncbi.nlm.nih.gov/38568462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,39753944,Novel variants of FSIP2 and SPEF2 cause varying degrees of spermatozoa damage in MMAF patients and favorable ART outcomes.,2025,10.1007/s10815-024-03378-1,https://pubmed.ncbi.nlm.nih.gov/39753944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,40898687,CFAP300 loss-of-function variant causes primary ciliary dyskinesia and male infertility via disrupting sperm flagellar assembly and acrosome formation.,2025,10.4103/aja202556,https://pubmed.ncbi.nlm.nih.gov/40898687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,36615117,Novel SPEF2 Variant in a Japanese Patient with Primary Ciliary Dyskinesia: A Case Report and Literature Review.,2022,10.3390/jcm12010317,https://pubmed.ncbi.nlm.nih.gov/36615117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,35965828,The ciliary protein Spef2 stimulates acinar Ampkα/Sirt1 signaling and ameliorates acute pancreatitis and associated lung injury.,2022,10.21037/atm-22-3118,https://pubmed.ncbi.nlm.nih.gov/35965828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,39312031,CATSPER2 and SPEF2 are potential molecular markers for boar sperm quality: a population association study.,2024,10.1007/s10815-024-03252-0,https://pubmed.ncbi.nlm.nih.gov/39312031/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,34755699,Sperm flagellar 2 (SPEF2) is essential for sperm flagellar assembly in humans.,2022,10.4103/aja202154,https://pubmed.ncbi.nlm.nih.gov/34755699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,39558053,Airway ciliary microenvironment responses in mice with primary ciliary dyskinesia and central pair apparatus defects.,2024,10.1038/s41598-024-79877-z,https://pubmed.ncbi.nlm.nih.gov/39558053/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,36873931,"Pathogenic gene variants in CCDC39, CCDC40, RSPH1, RSPH9, HYDIN, and SPEF2 cause defects of sperm flagella composition and male infertility.",2023,10.3389/fgene.2023.1117821,https://pubmed.ncbi.nlm.nih.gov/36873931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,40376536,Establishment and clinical significance of genetic factor screening method for patients with nonobstructive azoospermia based on whole exon sequencing technology.,2025,10.21037/tau-2024-676,https://pubmed.ncbi.nlm.nih.gov/40376536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,31408832,"Goat SPEF2: Expression profile, indel variants identification and association analysis with litter size.",2019,10.1016/j.theriogenology.2019.08.007,https://pubmed.ncbi.nlm.nih.gov/31408832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,32704025,"Genetic interaction between central pair apparatus genes CFAP221, CFAP54, and SPEF2 in mouse models of primary ciliary dyskinesia.",2020,10.1038/s41598-020-69359-3,https://pubmed.ncbi.nlm.nih.gov/32704025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,29339787,Cilia-related protein SPEF2 regulates osteoblast differentiation.,2018,10.1038/s41598-018-19204-5,https://pubmed.ncbi.nlm.nih.gov/29339787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,34679903,"Search for Associations of FSHR, INHA, INHAB, PRL, TNP2 and SPEF2 Genes Polymorphisms with Semen Quality in Russian Holstein Bulls (Pilot Study).",2021,10.3390/ani11102882,https://pubmed.ncbi.nlm.nih.gov/34679903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,36617567,ATAC-seq and RNA-seq analysis unravel the mechanism of sex differentiation and infertility in sex reversal chicken.,2023,10.1186/s13072-022-00476-1,https://pubmed.ncbi.nlm.nih.gov/36617567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,41199169,Whole-genome resequencing uncovers population structure and candidate molecular markers for litter size in hetian sheep.,2025,10.1186/s12864-025-12168-7,https://pubmed.ncbi.nlm.nih.gov/41199169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,34932939,Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice.,2022,10.1016/j.ajhg.2021.11.022,https://pubmed.ncbi.nlm.nih.gov/34932939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,38200094,Strong selection signatures for Aleutian disease tolerance acting on novel candidate genes linked to immune and cellular responses in American mink (Neogale vison).,2024,10.1038/s41598-023-51039-7,https://pubmed.ncbi.nlm.nih.gov/38200094/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,36360263,Population Structure and Selection Signatures Underlying Domestication Inferred from Genome-Wide Copy Number Variations in Chinese Indigenous Pigs.,2022,10.3390/genes13112026,https://pubmed.ncbi.nlm.nih.gov/36360263/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,35500227,"Racial and ethnic differences in clonal hematopoiesis, tumor markers, and outcomes of patients with multiple myeloma.",2022,10.1182/bloodadvances.2021006652,https://pubmed.ncbi.nlm.nih.gov/35500227/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,37001189,Microcystin leucine arginine induces human sperm damage: Involvement of the Ca2+/CaMKKβ/AMPK pathway.,2023,10.1016/j.ecoenv.2023.114845,https://pubmed.ncbi.nlm.nih.gov/37001189/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,28574850,Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients.,2017,10.18632/oncotarget.17959,https://pubmed.ncbi.nlm.nih.gov/28574850/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,34386042,"Genome-Wide Analyses Reveal the Genetic Architecture and Candidate Genes of Indicine, Taurine, Synthetic Crossbreds, and Locally Adapted Cattle in Brazil.",2021,10.3389/fgene.2021.702822,https://pubmed.ncbi.nlm.nih.gov/34386042/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPEF2,ENSG00000152582,Unsafe,24360193,Enhanced response to pulmonary Streptococcus pneumoniae infection is associated with primary ciliary dyskinesia in mice lacking Pcdp1 and Spef2.,2013,10.1186/2046-2530-2-18,https://pubmed.ncbi.nlm.nih.gov/24360193/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,42432034,SPINK2 in hematopoiesis and cancer: Biology and clinical implications.,2026,10.1038/s41420-026-03206-8,https://pubmed.ncbi.nlm.nih.gov/42432034/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,41776172,SPINK2 silencing suppresses leukemic proliferation and restores myeloid commitment via MECOM downregulation in acute myeloid leukaemia.,2026,10.1038/s41420-026-02988-1,https://pubmed.ncbi.nlm.nih.gov/41776172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,41842707,Therapeutic Targets for Lung Squamous Cell Carcinoma: Proteome-Wide Mendelian Randomization and Potential Drug Prediction.,2026,10.1111/crj.70182,https://pubmed.ncbi.nlm.nih.gov/41842707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,42658018,Integration of Proteomics and Phenomics to Reveal Molecular Differences in High and Low Semen Quality in Donkeys.,2026,10.1111/rda.70314,https://pubmed.ncbi.nlm.nih.gov/42658018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,42729953,Identification of ultrasound-associated gene candidates in myeloid cells and construction of a prognostic risk model for acute myeloid leukemia.,2026,10.7717/peerj.21661,https://pubmed.ncbi.nlm.nih.gov/42729953/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,42277943,Single-cell RNA sequencing reveals chemotherapy-induced apoptosis in acute myeloid leukemia via B cell depletion and M2 to M1 macrophage repolarization.,2026,10.1186/s40246-026-01001-1,https://pubmed.ncbi.nlm.nih.gov/42277943/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,41616039,"Identification of deleterious missense variants of serine peptidase inhibitor Kazal type 2 gene and their impact on KAZAL domain structure, stability, flexibility, and dimension.",2026,10.1080/07391102.2026.2618605,https://pubmed.ncbi.nlm.nih.gov/41616039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,41948341,Integrative profiling of lactylation reveals prognostic biomarkers and an immunosuppressive niche in acute myeloid leukemia.,2026,10.3389/fimmu.2026.1765979,https://pubmed.ncbi.nlm.nih.gov/41948341/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,40681857,Expression of marker genes to assess the spermatogenic capacity in patients with idiopathic non-obstructive azoospermia.,2025,10.1007/s10815-025-03584-5,https://pubmed.ncbi.nlm.nih.gov/40681857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,38388961,RARRES1 inhibits hepatocellular carcinoma progression and increases its sensitivity to lenvatinib through interaction with SPINK2.,2024,10.1186/s13062-024-00459-0,https://pubmed.ncbi.nlm.nih.gov/38388961/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,41724374,First insight into the regulatory role of the glycoprotein hormones GPA2 and GPB5 in the small-spotted catshark (Scyliorhinus canicula L.) during spermiogenesis.,2026,10.1016/j.jprot.2026.105627,https://pubmed.ncbi.nlm.nih.gov/41724374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,36462395,"Characterization of SPINK2, SPACA7 and PDCL2: Effect of immunization on fecundity, sperm function and testicular transcriptome.",2023,10.1016/j.repbio.2022.100711,https://pubmed.ncbi.nlm.nih.gov/36462395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,41908943,Computational and Experimental Biology Reveals Dihydroartemisinin's Efficacy Against Steroid-Induced Osteonecrosis of the Femoral Head Adjusting Ferroptosis via CCL17-PRDX6.,2026,10.2147/dddt.s574294,https://pubmed.ncbi.nlm.nih.gov/41908943/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,41780767,Comparison of single-cell sequencing technologies for allele-specific expression analysis in rabbit spermatids.,2026,10.1016/j.ygeno.2026.111224,https://pubmed.ncbi.nlm.nih.gov/41780767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,37298647,SPINK2 Protein Expression Is an Independent Adverse Prognostic Marker in AML and Is Potentially Implicated in the Regulation of Ferroptosis and Immune Response.,2023,10.3390/ijms24119696,https://pubmed.ncbi.nlm.nih.gov/37298647/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,37378330,Temporary serine protease inhibition and the role of SPINK2 in human bone marrow.,2023,10.1016/j.isci.2023.106949,https://pubmed.ncbi.nlm.nih.gov/37378330/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,35173838,SPINK2 is a prognostic biomarker related to immune infiltration in acute myeloid leukemia.,2022,,https://pubmed.ncbi.nlm.nih.gov/35173838/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,42588684,DNA Methylation of Pharmacologic and Leukemia-Related Genes Predicts Clinical Outcomes in Pediatric Acute Myeloid Leukemia.,2026,10.3390/cancers18152467,https://pubmed.ncbi.nlm.nih.gov/42588684/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,37359898,Upregulation of SPINK2 in acute myeloid leukemia.,2023,10.1515/almed-2022-0047,https://pubmed.ncbi.nlm.nih.gov/37359898/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,39737198,Single-cell transcriptomics reveals heterogeneity and prognostic markers of myeloid precursor cells in acute myeloid leukemia.,2024,10.3389/fimmu.2024.1494106,https://pubmed.ncbi.nlm.nih.gov/39737198/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,39227582,Efficient generation of human NOTCH ligand-expressing haemogenic endothelial cells as infrastructure for in vitro haematopoiesis and lymphopoiesis.,2024,10.1038/s41467-024-51974-7,https://pubmed.ncbi.nlm.nih.gov/39227582/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,39506790,Dissecting L-glutamine metabolism in acute myeloid leukemia: single-cell insights and therapeutic implications.,2024,10.1186/s12967-024-05779-3,https://pubmed.ncbi.nlm.nih.gov/39506790/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,39053673,Methylation and transcriptome analyses construct a prognostic model and reveal the suppressor role of VMO1 in lung adenocarcinoma.,2024,10.1016/j.cellsig.2024.111313,https://pubmed.ncbi.nlm.nih.gov/39053673/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,28554943,SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia in homozygotes.,2017,10.15252/emmm.201607461,https://pubmed.ncbi.nlm.nih.gov/28554943/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,33925480,NUP-98 Rearrangements Led to the Identification of Candidate Biomarkers for Primary Induction Failure in Pediatric Acute Myeloid Leukemia.,2021,10.3390/ijms22094575,https://pubmed.ncbi.nlm.nih.gov/33925480/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINK2,ENSG00000128040,Unsafe,20736409,Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.,2010,10.1074/mcp.m110.001719,https://pubmed.ncbi.nlm.nih.gov/20736409/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINT3,ENSG00000101446,Unsafe,39665756,Large-scale CRISPR/Cas9 deletions within the WFDC gene cluster uncover gene functionality and critical roles in mammalian reproduction.,2024,10.1073/pnas.2413195121,https://pubmed.ncbi.nlm.nih.gov/39665756/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINT3,ENSG00000101446,Unsafe,40224648,Sex differences in proteomics of cardiovascular disease - &lt;i&gt;Results from the Yale-CMD registry&lt;/i&gt;.,2025,10.1016/j.ijcha.2025.101667,https://pubmed.ncbi.nlm.nih.gov/40224648/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINT3,ENSG00000101446,Unsafe,36959545,Discovery of novel glioma serum biomarkers by proximity extension assay.,2023,10.1186/s12014-023-09400-5,https://pubmed.ncbi.nlm.nih.gov/36959545/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINT3,ENSG00000101446,Unsafe,39972314,Potential drug targets for ovarian cancer identified through Mendelian randomization and colocalization analysis.,2025,10.1186/s13048-025-01620-7,https://pubmed.ncbi.nlm.nih.gov/39972314/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINT3,ENSG00000101446,Unsafe,32814578,Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets.,2020,10.1186/s12915-020-00826-z,https://pubmed.ncbi.nlm.nih.gov/32814578/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINT3,ENSG00000101446,Unsafe,21988899,Three genes expressing Kunitz domains in the epididymis are related to genes of WFDC-type protease inhibitors and semen coagulum proteins in spite of lacking similarity between their protein products.,2011,10.1186/1471-2091-12-55,https://pubmed.ncbi.nlm.nih.gov/21988899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINT4,ENSG00000149651,Unsafe,39665756,Large-scale CRISPR/Cas9 deletions within the WFDC gene cluster uncover gene functionality and critical roles in mammalian reproduction.,2024,10.1073/pnas.2413195121,https://pubmed.ncbi.nlm.nih.gov/39665756/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINT4,ENSG00000149651,Unsafe,40428390,Genome-Wide Analysis of Copy Number Variations in Three Populations of Nanyang Cattle Using Whole-Genome Resequencing.,2025,10.3390/genes16050568,https://pubmed.ncbi.nlm.nih.gov/40428390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINT4,ENSG00000149651,Unsafe,32814578,Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets.,2020,10.1186/s12915-020-00826-z,https://pubmed.ncbi.nlm.nih.gov/32814578/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINT4,ENSG00000149651,Unsafe,32030088,Comparative RNA-Seq Analysis of Differentially Expressed Genes in the Epididymides of Yak and Cattleyak.,2019,10.2174/1389202920666190809092819,https://pubmed.ncbi.nlm.nih.gov/32030088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINT4,ENSG00000149651,Unsafe,21536719,Differing evolutionary histories of WFDC8 (short-term balancing) in Europeans and SPINT4 (incomplete selective sweep) in Africans.,2011,10.1093/molbev/msr106,https://pubmed.ncbi.nlm.nih.gov/21536719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINT4,ENSG00000149651,Unsafe,21988899,Three genes expressing Kunitz domains in the epididymis are related to genes of WFDC-type protease inhibitors and semen coagulum proteins in spite of lacking similarity between their protein products.,2011,10.1186/1471-2091-12-55,https://pubmed.ncbi.nlm.nih.gov/21988899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPINT4,ENSG00000149651,Unsafe,12920233,Discovery in silico and characterization in vitro of novel genes exclusively expressed in the mouse epididymis.,2003,10.1210/me.2003-0008,https://pubmed.ncbi.nlm.nih.gov/12920233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP4,ENSG00000153790,Unsafe,42770300,Mitochonic acid 5 alleviates amyotrophic lateral sclerosis phenotypes via mitochondrial augmentation.,2026,10.1172/jci.insight.200761,https://pubmed.ncbi.nlm.nih.gov/42770300/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP4,ENSG00000153790,Unsafe,35180297,Genetic pleiotropy between pulmonary function and age-related traits: The Long Life Family Study.,2022,10.1093/gerona/glac046,https://pubmed.ncbi.nlm.nih.gov/35180297/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP4,ENSG00000153790,Unsafe,30064229,"LINGO1, C7orf31 and VEGFA are prognostic genes of primary glioblastoma: analysis of gene expression microarray.",2018,10.4149/neo_2018_170722n496,https://pubmed.ncbi.nlm.nih.gov/30064229/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP4,ENSG00000153790,Unsafe,25074808,Proteomic analysis of mammalian sperm cells identifies new components of the centrosome.,2014,10.1242/jcs.157008,https://pubmed.ncbi.nlm.nih.gov/25074808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP4,ENSG00000153790,Unsafe,32588039,CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction†.,2020,10.1093/biolre/ioaa083,https://pubmed.ncbi.nlm.nih.gov/32588039/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP5,ENSG00000165863,Unsafe,36355490,The Expression Patterns of Human Cancer-Testis Genes Are Induced through Epigenetic Drugs in Colon Cancer Cells.,2022,10.3390/ph15111319,https://pubmed.ncbi.nlm.nih.gov/36355490/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP5,ENSG00000165863,Unsafe,31462944,Identification of clinical trait-related lncRNA and mRNA biomarkers with weighted gene co-expression network analysis as useful tool for personalized medicine in ovarian cancer.,2019,10.1007/s13167-019-00175-0,https://pubmed.ncbi.nlm.nih.gov/31462944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPMIP5,ENSG00000165863,Unsafe,25609838,Combining RNA and protein profiling data with network interactions identifies genes associated with spermatogenesis in mouse and human.,2015,10.1095/biolreprod.114.126250,https://pubmed.ncbi.nlm.nih.gov/25609838/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,42519029,Downregulation of SPRED1 drives keratinocyte hyperproliferation in psoriasis via activation of the ERK-RSK1 signaling axis.,2026,10.1016/j.isci.2026.116812,https://pubmed.ncbi.nlm.nih.gov/42519029/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,40948827,Enhancing the sensitivity of lung adenocarcinoma to immune therapeutic agents through &lt;i&gt;SPRED1&lt;/i&gt;.,2025,10.21037/tlcr-2025-800,https://pubmed.ncbi.nlm.nih.gov/40948827/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,42201959,NF1 and SPRED1/2 cooperate through RAS-MAPK-independent functions.,2026,10.1073/pnas.2535319123,https://pubmed.ncbi.nlm.nih.gov/42201959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,42587751,Conserved Hypoxia-Responsive miRNA Programs Define Adaptive and Stress-Limiting Regulatory Axes in Hepatocellular Carcinoma.,2026,10.3390/cells15151341,https://pubmed.ncbi.nlm.nih.gov/42587751/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,41094606,The role of SPRED1 mutation in melanoma.,2025,10.1186/s40001-025-03267-y,https://pubmed.ncbi.nlm.nih.gov/41094606/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,42809100,A multi-omics and machine-learning framework reveals shared druggable targets for Alzheimer's disease and periodontitis and identifies amentoflavone and taraxerone as potential dual-action natural products.,2026,10.1007/s00210-026-05953-y,https://pubmed.ncbi.nlm.nih.gov/42809100/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,41208883,TTC36-Mediated Tumor Suppression via YBX3/SPRED1 Axis Paradoxically Reduces Sorafenib Sensitivity in Hepatocellular Carcinoma.,2025,10.7150/ijbs.115727,https://pubmed.ncbi.nlm.nih.gov/41208883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,42840422,Aptamer-guided delivery of miR-126 suppresses glioblastoma stem-like cell invasion and tumor progression.,2026,10.1016/j.omtn.2026.103103,https://pubmed.ncbi.nlm.nih.gov/42840422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,41904680,Cancer risk in adults with pathogenic germline variants in RAS/MAPK genes using genomic ascertainment.,2026,10.1016/j.gim.2026.102561,https://pubmed.ncbi.nlm.nih.gov/41904680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,40806788,"Loss of SPRED3 Causes Primary Hypothyroidism and Alters Thyroidal Expression of Autophagy Regulators LC3, p62, and ATG5 in Mice.",2025,10.3390/ijms26157660,https://pubmed.ncbi.nlm.nih.gov/40806788/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,41630929,Variant Resolution Through RNA Testing and Affected Tissue Analysis in the Neurofibromatoses: A Case Series.,2026,10.1212/nxg.0000000000200347,https://pubmed.ncbi.nlm.nih.gov/41630929/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,39510187,Legius syndrome mutations in the Ras-regulator SPRED1 abolish its membrane localization and potentially cause neurodegeneration.,2024,10.1016/j.jbc.2024.107969,https://pubmed.ncbi.nlm.nih.gov/39510187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,42248117,Generation and characterization of four iPSC and isogenic gene-corrected lines from Legius syndrome patients.,2026,10.1016/j.scr.2026.104026,https://pubmed.ncbi.nlm.nih.gov/42248117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,40358892,miR-486-3p Suppresses Osteosarcoma Proliferation and Migration by Targeting the SPRED1-MAPK/ERK Pathway.,2026,10.1007/s10528-025-11128-w,https://pubmed.ncbi.nlm.nih.gov/40358892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,39495984,Pancancer analysis of the interactions between CTNNB1 and infiltrating immune cell populations.,2024,10.1097/md.0000000000040186,https://pubmed.ncbi.nlm.nih.gov/39495984/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,41641015,The potential mechanisms and regulatory roles of exosomal miRNA in neural repair after spinal cord injury.,2025,10.3389/fncel.2025.1711454,https://pubmed.ncbi.nlm.nih.gov/41641015/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,40635095,NSC-derived extracellular vesicles-mediates neuronal plasticity enhancement in vascular dementia via transferring miR-210.,2025,10.1186/s40478-025-02073-1,https://pubmed.ncbi.nlm.nih.gov/40635095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,40644385,"Integrative Genomic, Transcriptomic and Epigenomic Analysis Reveals cis-regulatory Contributions to High-altitude Adaptation in Tibetan Pigs.",2025,10.1093/molbev/msaf169,https://pubmed.ncbi.nlm.nih.gov/40644385/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,40051658,Longitudinal profiling of IDH-mutant astrocytomas reveals acquired RAS-MAPK pathway mutations associated with inferior survival.,2025,10.1093/noajnl/vdaf024,https://pubmed.ncbi.nlm.nih.gov/40051658/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,41155378,"Neurofibromin Encoded by the Neurofibromatosis Type 1 (NF1) Gene Promotes the Membrane Translocation of SPRED2, Thereby Inhibiting the ERK Pathway in Breast Cancer Cells.",2025,10.3390/ijms262010072,https://pubmed.ncbi.nlm.nih.gov/41155378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,40756116,A novel patient-derived cutaneous melanoma cell line reveals key features of metastatic melanoma.,2025,10.3389/fonc.2025.1531013,https://pubmed.ncbi.nlm.nih.gov/40756116/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,37343716,Oxidative Stress-mediated Sprouty-related Protein with an EVH1 Domain 1 Down-regulation Contributes to Resisting Oxidative Injury in Microglia.,2023,10.1016/j.neuroscience.2023.06.012,https://pubmed.ncbi.nlm.nih.gov/37343716/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,38233508,Prediction of CAF-related genes in immunotherapy and drug sensitivity in hepatocellular carcinoma: a multi-database analysis.,2024,10.1038/s41435-024-00252-z,https://pubmed.ncbi.nlm.nih.gov/38233508/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,37396522,"miR-126-5p affects the chemosensitivity of colorectal cancer cells by regulating SPRED1, ERK1/2 pathway and apoptosis.",2023,10.1016/j.gendis.2022.05.024,https://pubmed.ncbi.nlm.nih.gov/37396522/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,41774747,Integrating sequence-based GWAS and comparative genomic analysis reveals conservation and species-specificity of putative functional variants influencing tail length and tail abnormalities in pigs and sheep.,2026,10.1371/journal.pone.0343836,https://pubmed.ncbi.nlm.nih.gov/41774747/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,41876476,Identification of acetylation-related molecular signatures in knee osteoarthritis patients with significant response to warm-needle acupuncture using machine-learning approaches.,2026,10.1177/17448069261439615,https://pubmed.ncbi.nlm.nih.gov/41876476/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,34564700,Spred1 deficit promotes treatment resistance and transformation of chronic phase CML.,2022,10.1038/s41375-021-01423-x,https://pubmed.ncbi.nlm.nih.gov/34564700/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,34311771,MEK inhibition ameliorates social behavior phenotypes in a Spred1 knockout mouse model for RASopathy disorders.,2021,10.1186/s13229-021-00458-2,https://pubmed.ncbi.nlm.nih.gov/34311771/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,39295275,ASCL1 Restrains ERK1/2 to Promote Survival of a Subset of Neuroendocrine Lung Cancers.,2024,10.1158/1535-7163.mct-24-0355,https://pubmed.ncbi.nlm.nih.gov/39295275/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,38107964,Monkeypox Virus Crosstalk with HIV: An Integrated Skin Transcriptome and Machine Learning Study.,2023,10.1021/acsomega.3c07687,https://pubmed.ncbi.nlm.nih.gov/38107964/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,32175275,SPRED1 Is Downregulated and a Prognostic Biomarker in Adult Acute Myeloid Leukemia.,2020,10.3389/fonc.2020.00204,https://pubmed.ncbi.nlm.nih.gov/32175275/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,38217548,Combination of bulk RNA sequencing and scRNA sequencing uncover the molecular characteristics of MAPK signaling in kidney renal clear cell carcinoma.,2024,10.18632/aging.205436,https://pubmed.ncbi.nlm.nih.gov/38217548/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRED1,ENSG00000166068,Unsafe,15580519,Expression and subcellular localization of Spred proteins in mouse and human tissues.,2004,10.1007/s00418-004-0725-6,https://pubmed.ncbi.nlm.nih.gov/15580519/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,39272266,Novel Single-Nucleotide Polymorphisms (SNPs) and Genetic Studies of the Shadow of Prion Protein (SPRN) in Quails.,2024,10.3390/ani14172481,https://pubmed.ncbi.nlm.nih.gov/39272266/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,39765621,Novel Insertion/Deletion Polymorphisms and Genetic Studies of the Shadow of Prion Protein (SPRN) in Raccoon Dogs.,2024,10.3390/ani14243716,https://pubmed.ncbi.nlm.nih.gov/39765621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,38929426,First Report of Single Nucleotide Polymorphisms (SNPs) of the Leporine Shadow of Prion Protein Gene (SPRN) and Absence of Nonsynonymous SNPs in the Open Reading Frame (ORF) in Rabbits.,2024,10.3390/ani14121807,https://pubmed.ncbi.nlm.nih.gov/38929426/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,38891635,The First Genetic Characterization of the SPRN Gene in Pekin Ducks (Anas platyrhynchos domesticus).,2024,10.3390/ani14111588,https://pubmed.ncbi.nlm.nih.gov/38891635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,41123810,Differential gene expression in peripheral vascular smooth muscle cells of patients with peripheral artery disease.,2026,10.1007/s10157-025-02774-w,https://pubmed.ncbi.nlm.nih.gov/41123810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,40204637,The prion-family protein Doppel exerts a protective role during influenza virus infection.,2025,10.1093/jimmun/vkaf031,https://pubmed.ncbi.nlm.nih.gov/40204637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,38812560,Novel polymorphisms and genetic studies of the shadow of prion protein gene (SPRN) in pheasants.,2024,10.3389/fvets.2024.1399548,https://pubmed.ncbi.nlm.nih.gov/38812560/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,41170269,The Implementation of Faricimab in East Lancashire NHS Trust: Highlighting the Real-World Efficacy and Safety in Patients With Neovascular Age-Related Macular Degeneration.,2025,10.7759/cureus.93478,https://pubmed.ncbi.nlm.nih.gov/41170269/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,35632724,"Novel Polymorphisms and Genetic Characteristics of the Shadow of Prion Protein Gene (SPRN) in Cats, Hosts of Feline Spongiform Encephalopathy.",2022,10.3390/v14050981,https://pubmed.ncbi.nlm.nih.gov/35632724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,35799279,Potential genetic robustness of Prnp and Sprn double knockout mouse embryos towards ShRNA-lentiviral inoculation.,2022,10.1186/s13567-022-01075-4,https://pubmed.ncbi.nlm.nih.gov/35799279/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,35151978,Post-transcriptional silencing of Bos taurus prion family genes and its impact on granulosa cell steroidogenesis.,2022,10.1016/j.bbrc.2022.02.012,https://pubmed.ncbi.nlm.nih.gov/35151978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,35982928,"Novel insertion/deletion polymorphisms and genetic features of the shadow of prion protein gene (SPRN) in dogs, a prion-resistant animal.",2022,10.3389/fvets.2022.942289,https://pubmed.ncbi.nlm.nih.gov/35982928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,34573540,"The First Report of Genetic Polymorphisms of the Equine SPRN Gene in Outbred Horses, Jeju and Halla Horses.",2021,10.3390/ani11092574,https://pubmed.ncbi.nlm.nih.gov/34573540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,35782543,"The First Report of Polymorphisms and Genetic Characteristics of the Shadow of Prion Protein (SPRN) in Prion Disease-Resistant Animal, Chickens.",2022,10.3389/fvets.2022.904305,https://pubmed.ncbi.nlm.nih.gov/35782543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,32943703,Polymorphisms of shadow of prion protein gene (SPRN) in Korean native cattle (Hanwoo) and Holstein cattle.,2020,10.1038/s41598-020-72225-x,https://pubmed.ncbi.nlm.nih.gov/32943703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,32317725,The Prion-like protein Shadoo is involved in mouse embryonic and mammary development and differentiation.,2020,10.1038/s41598-020-63805-y,https://pubmed.ncbi.nlm.nih.gov/32317725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,31905681,"The First Report of Genetic and Structural Diversities in the SPRN Gene in the Horse, an Animal Resistant to Prion Disease.",2019,10.3390/genes11010039,https://pubmed.ncbi.nlm.nih.gov/31905681/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,31649311,Scrapie susceptibility-associated indel polymorphism of shadow of prion protein gene (SPRN) in Korean native black goats.,2019,10.1038/s41598-019-51625-8,https://pubmed.ncbi.nlm.nih.gov/31649311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,25364761,Role of the prion protein family in the gonads.,2014,10.3389/fcell.2014.00056,https://pubmed.ncbi.nlm.nih.gov/25364761/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,25265054,Spermitin: a novel mitochondrial protein in Drosophila spermatids.,2014,10.1371/journal.pone.0108802,https://pubmed.ncbi.nlm.nih.gov/25265054/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,42611868,A strengthened soft-point registration network for LiDAR point cloud registration.,2026,10.1371/journal.pone.0355292,https://pubmed.ncbi.nlm.nih.gov/42611868/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,35869782,A Modified Ultra-Sensitive ELISA for Measurement of LH in Mice.,2022,10.1210/endocr/bqac109,https://pubmed.ncbi.nlm.nih.gov/35869782/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,30779607,The Special Pathogens Research Network: Enabling Research Readiness.,2019,10.1089/hs.2018.0106,https://pubmed.ncbi.nlm.nih.gov/30779607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,35077391,Novel necroptosis-related gene signature for predicting the prognosis of pancreatic adenocarcinoma.,2022,10.18632/aging.203846,https://pubmed.ncbi.nlm.nih.gov/35077391/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,27561286,Utilisation of cardiac pacemakers over a 20-year period: Results from a nationwide pacemaker registry.,2017,10.1007/s12471-016-0880-0,https://pubmed.ncbi.nlm.nih.gov/27561286/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,30512033,Genomic Analysis and Prediction within a US Public Collaborative Winter Wheat Regional Testing Nursery.,2018,10.3835/plantgenome2018.01.0004,https://pubmed.ncbi.nlm.nih.gov/30512033/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,19657386,Frequent missense and insertion/deletion polymorphisms in the ovine Shadoo gene parallel species-specific variation in PrP.,2009,10.1371/journal.pone.0006538,https://pubmed.ncbi.nlm.nih.gov/19657386/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,23071594,Comparative analysis of the Shadoo gene between cattle and buffalo reveals significant differences.,2012,10.1371/journal.pone.0046601,https://pubmed.ncbi.nlm.nih.gov/23071594/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,17703189,The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections.,2007,10.1038/sj.emboj.7601830,https://pubmed.ncbi.nlm.nih.gov/17703189/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,22114562,Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation.,2011,10.1371/journal.ppat.1002391,https://pubmed.ncbi.nlm.nih.gov/22114562/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,19798432,Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones.,2009,10.1371/journal.ppat.1000608,https://pubmed.ncbi.nlm.nih.gov/19798432/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRN,ENSG00000203772,Unsafe,14527721,"Shadoo, a new protein highly conserved from fish to mammals and with similarity to prion protein.",2003,10.1016/s0378-1119(03)00707-8,https://pubmed.ncbi.nlm.nih.gov/14527721/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRR4,ENSG00000184148,Unsafe,40598168,Identification of mitophagy-related biomarkers with immune cell infiltration in psoriasis.,2025,10.1186/s12920-025-02176-7,https://pubmed.ncbi.nlm.nih.gov/40598168/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRR4,ENSG00000184148,Unsafe,41265305,Lasia spinosa supplementation improves semen quality and sperm cryosurvival in subfertile beef bulls: An exploratory testicular transcriptomic analysis.,2025,10.1016/j.anireprosci.2025.108043,https://pubmed.ncbi.nlm.nih.gov/41265305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRR4,ENSG00000184148,Unsafe,32978827,Markers for Ca++ -induced terminal differentiation of keratinocytes in vitro under defined conditions.,2020,10.1111/exd.14199,https://pubmed.ncbi.nlm.nih.gov/32978827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRR4,ENSG00000184148,Unsafe,28119736,Recent Positive Selection in Genes of the Mammalian Epidermal Differentiation Complex Locus.,2016,10.3389/fgene.2016.00227,https://pubmed.ncbi.nlm.nih.gov/28119736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRR4,ENSG00000184148,Unsafe,33181142,Isosorbide Di-(Linoleate/Oleate) Stimulates Prodifferentiation Gene Expression to Restore the Epidermal Barrier and Improve Skin Hydration.,2021,10.1016/j.jid.2020.09.029,https://pubmed.ncbi.nlm.nih.gov/33181142/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRR4,ENSG00000184148,Unsafe,30272454,Integration of Transcriptomics and Antibody-Based Proteomics for Exploration of Proteins Expressed in Specialized Tissues.,2018,10.1021/acs.jproteome.8b00406,https://pubmed.ncbi.nlm.nih.gov/30272454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRR4,ENSG00000184148,Unsafe,11719550,"SPRR4, a novel cornified envelope precursor: UV-dependent epidermal expression and selective incorporation into fragile envelopes.",2001,10.1242/jcs.114.21.3837,https://pubmed.ncbi.nlm.nih.gov/11719550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRR4,ENSG00000184148,Unsafe,22142393,The effect of pimecrolimus on expression of genes associated with skin barrier dysfunction in atopic dermatitis skin lesions.,2012,10.1111/j.1600-0625.2011.01417.x,https://pubmed.ncbi.nlm.nih.gov/22142393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRR4,ENSG00000184148,Unsafe,11279051,Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function.,2001,10.1074/jbc.m100336200,https://pubmed.ncbi.nlm.nih.gov/11279051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRR4,ENSG00000184148,Unsafe,12584609,Mouse Sprr locus: a tandem array of coordinately regulated genes.,2003,10.1007/s00335-002-2205-4,https://pubmed.ncbi.nlm.nih.gov/12584609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,42676598,SPRTN preserves RNA polymerase I transcription under genotoxic drug stress in lung adenocarcinoma.,2026,10.3389/fonc.2026.1917106,https://pubmed.ncbi.nlm.nih.gov/42676598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,40691134,Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability.,2025,10.1038/s41467-025-61224-z,https://pubmed.ncbi.nlm.nih.gov/40691134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,41995195,Isotope Dilution NanoLC-MS/MS Quantitation of Methylglyoxal DNA-Protein Cross-Links: Formation and Repair in Human Cells.,2026,10.1021/acs.analchem.5c06852,https://pubmed.ncbi.nlm.nih.gov/41995195/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,39730693,SPRTN metalloprotease participates in repair of ROS-mediated DNA-protein crosslinks.,2024,10.1038/s41598-024-81799-9,https://pubmed.ncbi.nlm.nih.gov/39730693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,39290288,"Nitrogen mustard induces dynamic nuclear protein spectrum change and DNA-protein crosslinking, with p97 mediating repair.",2024,10.1016/j.heliyon.2024.e37401,https://pubmed.ncbi.nlm.nih.gov/39290288/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,42129541,A CHK1-mediated phosphorylation switch suppresses human Topoisomerase 1-associated genomic instability.,2026,10.1038/s44318-026-00783-3,https://pubmed.ncbi.nlm.nih.gov/42129541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,37788708,Tyrosyl-DNA phosphodiesterase 1 (TDP1) and SPRTN protease repair histone 3 and topoisomerase 1 DNA-protein crosslinks in vivo.,2023,10.1098/rsob.230113,https://pubmed.ncbi.nlm.nih.gov/37788708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,38086993,SPRTN is involved in hepatocellular carcinoma development through the ER stress response.,2024,10.1038/s41417-023-00708-w,https://pubmed.ncbi.nlm.nih.gov/38086993/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,42653448,Genetic Modifiers of Cardiac Remodeling Severity in IVS4+919G&gt;A-Associated Fabry Cardiomyopathy.,2026,10.3390/ijms27167447,https://pubmed.ncbi.nlm.nih.gov/42653448/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,39028621,PARP1-driven repair of topoisomerase IIIα DNA-protein crosslinks by FEN1.,2024,10.1016/j.celrep.2024.114522,https://pubmed.ncbi.nlm.nih.gov/39028621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,37024461,Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes.,2023,10.1038/s41467-023-37498-6,https://pubmed.ncbi.nlm.nih.gov/37024461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,36681662,SPRTN patient variants cause global-genome DNA-protein crosslink repair defects.,2023,10.1038/s41467-023-35988-1,https://pubmed.ncbi.nlm.nih.gov/36681662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,41543603,Signatures of high-altitude adaptation in Caucasus populations: evidence from the EGLN1-SPRTN locus.,2026,10.1007/s10709-026-00259-6,https://pubmed.ncbi.nlm.nih.gov/41543603/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,25261934,"Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features.",2014,10.1038/ng.3103,https://pubmed.ncbi.nlm.nih.gov/25261934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,38600236,Transcription-coupled DNA-protein crosslink repair by CSB and CRL4&lt;sup&gt;CSA&lt;/sup&gt;-mediated degradation.,2024,10.1038/s41556-024-01394-y,https://pubmed.ncbi.nlm.nih.gov/38600236/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,36718861,SPRTN-dependent DPC degradation precedes repair of damaged DNA: a proof of concept revealed by the STAR assay.,2023,10.1093/nar/gkad022,https://pubmed.ncbi.nlm.nih.gov/36718861/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,36282523,SPRTN and TDP1/TDP2 Independently Suppress 5-Aza-2'-deoxycytidine-Induced Genomic Instability in Human TK6 Cell Line.,2022,10.1021/acs.chemrestox.2c00213,https://pubmed.ncbi.nlm.nih.gov/36282523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,36608669,The FANCJ helicase unfolds DNA-protein crosslinks to promote their repair.,2023,10.1016/j.molcel.2022.12.005,https://pubmed.ncbi.nlm.nih.gov/36608669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,35782873,Mechanisms and Regulation of DNA-Protein Crosslink Repair During DNA Replication by SPRTN Protease.,2022,10.3389/fmolb.2022.916697,https://pubmed.ncbi.nlm.nih.gov/35782873/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,32649882,Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging.,2020,10.1016/j.molcel.2020.06.027,https://pubmed.ncbi.nlm.nih.gov/32649882/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,42912308,A Latent DNA-Protein Cross-Link Agent as a Chemical Adjuvant for Photodynamic Therapy.,2026,10.1021/jacs.6c13537,https://pubmed.ncbi.nlm.nih.gov/42912308/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,41610251,DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic lethality.,2026,10.1126/science.adx9445,https://pubmed.ncbi.nlm.nih.gov/41610251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,40828618,Examination of a Chimeric Bis-Electrophile for Selective DNA-Protein Cross-Linking and Mechlorethamine Reveals an Unknown Source of Nitrogen Mustard Cytotoxicity.,2025,10.1021/jacs.5c09293,https://pubmed.ncbi.nlm.nih.gov/40828618/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,37324923,An efficient DNAzyme for the fluorescence detection of Vibrio cholerae.,2023,10.1002/fsn3.3304,https://pubmed.ncbi.nlm.nih.gov/37324923/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,34879279,The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability.,2021,10.1016/j.celrep.2021.110080,https://pubmed.ncbi.nlm.nih.gov/34879279/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,38652696,Quantification of Intracellular DNA-Protein Cross-Links with N7-Methyl-2'-Deoxyguanosine and Their Contribution to Cytotoxicity.,2024,10.1021/acs.chemrestox.4c00076,https://pubmed.ncbi.nlm.nih.gov/38652696/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,34551432,Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1-DNA complexes.,2021,10.1093/nar/gkab777,https://pubmed.ncbi.nlm.nih.gov/34551432/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,27871366,Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.,2016,10.1016/j.molcel.2016.09.032,https://pubmed.ncbi.nlm.nih.gov/27871366/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,38084926,Isolation and detection of DNA-protein crosslinks in mammalian cells.,2024,10.1093/nar/gkad1178,https://pubmed.ncbi.nlm.nih.gov/38084926/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,30914427,SUMOylation promotes protective responses to DNA-protein crosslinks.,2019,10.15252/embj.2019101496,https://pubmed.ncbi.nlm.nih.gov/30914427/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,32853547,DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease.,2020,10.1016/j.molcel.2020.08.003,https://pubmed.ncbi.nlm.nih.gov/32853547/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,27418463,Improved quality of life in patients with no-option critical limb ischemia undergoing gene therapy with DVC1-0101.,2016,10.1038/srep30035,https://pubmed.ncbi.nlm.nih.gov/27418463/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,34189469,Protein-oligonucleotide conjugates as model substrates for DNA-protein crosslink repair proteases.,2021,10.1016/j.xpro.2021.100591,https://pubmed.ncbi.nlm.nih.gov/34189469/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,33668039,LncRNA-mRNA co-expression analysis discovered the diagnostic and prognostic biomarkers and potential therapeutic agents for myocardial infarction.,2021,10.18632/aging.202713,https://pubmed.ncbi.nlm.nih.gov/33668039/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,30170832,DNA protein crosslink proteolysis repair: From yeast to premature ageing and cancer in humans.,2018,10.1016/j.dnarep.2018.08.025,https://pubmed.ncbi.nlm.nih.gov/30170832/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPRTN,ENSG00000010072,Unsafe,23319060,DVC1-0101 to treat peripheral arterial disease: a Phase I/IIa open-label dose-escalation clinical trial.,2013,10.1038/mt.2012.279,https://pubmed.ncbi.nlm.nih.gov/23319060/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,42801053,Severe Hereditary Pyropoikilocytosis/Hereditary Elliptocytosis-Like Phenotype Associated With a Heterozygous &lt;i&gt;SPTA1&lt;/i&gt; Variant in a Cambodian Girl: A Case Report.,2026,10.1155/crh/9545062,https://pubmed.ncbi.nlm.nih.gov/42801053/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,42238882,A defined microbiota mouse model for &lt;i&gt;Salmonella&lt;/i&gt; Paratyphi A oral infection.,2026,10.3389/fmicb.2026.1824783,https://pubmed.ncbi.nlm.nih.gov/42238882/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,42908713,"Transcranial ultrasound stimulation of the right globus pallidus interna in schizophrenia: A randomized, sham-controlled pilot study.",2026,10.1038/s44384-026-00076-3,https://pubmed.ncbi.nlm.nih.gov/42908713/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,40717354,Hereditary Spherocytosis due to an SPTA1 Nonsense Mutation Coinherited With α spectrin&lt;sup&gt;LELY&lt;/sup&gt; in Trans.,2025,10.1002/ajh.70021,https://pubmed.ncbi.nlm.nih.gov/40717354/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,42350657,Spontaneous membrane protrusion and cell morphogenesis via self-propelled actin filaments.,2026,10.1038/s44319-026-00804-6,https://pubmed.ncbi.nlm.nih.gov/42350657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,41697720,Placental iron utilisation in fetal growth restriction: alterations in mitochondrial haem synthesis and iron-sulphur cluster assembly pathways.,2026,10.1113/jp289451,https://pubmed.ncbi.nlm.nih.gov/41697720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,42334200,Inter-rater reliability and construct validity of a cross-diagnostic movement quality score for rehabilitation assessment.,2026,10.2340/jrm.v58.45701,https://pubmed.ncbi.nlm.nih.gov/42334200/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,41020088,Hereditary elliptocytosis in a child with an autosomal recessive &lt;i&gt;SPTA1&lt;/i&gt; mutation: a case report from Saudi Arabia.,2025,10.25122/jml-2025-0038,https://pubmed.ncbi.nlm.nih.gov/41020088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,41098499,Homozygous α-Spectrin (SPTA1) Variant Causing Persistent Hereditary Pyropoikilocytosis in a Newborn: A Case Report and Literature Review.,2025,10.2147/imcrj.s483359,https://pubmed.ncbi.nlm.nih.gov/41098499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,41845437,Safety and neuromodulation effect of transcranial focused ultrasound for motor recovery in patients with subacute stroke.,2026,10.1186/s12984-026-01945-4,https://pubmed.ncbi.nlm.nih.gov/41845437/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,40797064,Focused ultrasound suppresses pentylenetetrazol-induced epileptiform activity in rats and alters connectivity measured by functional MRI.,2025,10.1038/s41598-025-15305-0,https://pubmed.ncbi.nlm.nih.gov/40797064/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,40486436,SPTA1-Related Hereditary Spherocytosis: Novel Compound Heterozygous Mutations With Severe Clinical Manifestation.,2025,10.7759/cureus.83724,https://pubmed.ncbi.nlm.nih.gov/40486436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,42387612,Plasma proteome differences between giant cell arteritis and polymyalgia rheumatica: a pilot study.,2026,10.1186/s13075-026-03852-4,https://pubmed.ncbi.nlm.nih.gov/42387612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,41914049,In-depth analysis of osmotic gradient ektacytometry parameters across different genotypes in hereditary spherocytosis.,2026,10.1111/bjh.70457,https://pubmed.ncbi.nlm.nih.gov/41914049/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,39833304,Dehydrocorydaline maintains the vascular smooth muscle cell contractile phenotype by upregulating Spta1.,2025,10.1038/s41401-024-01464-9,https://pubmed.ncbi.nlm.nih.gov/39833304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,39993792,Sculponeatin A induces mitochondrial dysfunction in non-small cell lung cancer through WWP2-mediated degradation of mitochondrial STAT3.,2025,10.1111/bph.17460,https://pubmed.ncbi.nlm.nih.gov/39993792/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,40956434,Genetic biomarkers and crucial cell subsets of iron metabolism in Beta-Thalassemia: insights from bioinformatics and experimental validation.,2025,10.1007/s00277-025-06605-6,https://pubmed.ncbi.nlm.nih.gov/40956434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,42150595,Distinct electrophysiological profiles of bacterial mechanosensitive channels for sonogenetic actuator selection.,2026,10.1088/1741-2552/ae6f83,https://pubmed.ncbi.nlm.nih.gov/42150595/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,42126446,Expanding the genetic spectrum of hereditary spherocytosis: novel mutations and phenotypic heterogeneity from a 55-patient cohort.,2026,10.1007/s00277-026-07066-1,https://pubmed.ncbi.nlm.nih.gov/42126446/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,41826520,"Integrated Liquid Biopsy and Tumor Tissue Genomic Profiling of Appendiceal Cancer: cfDNA Burden, Mutation Landscapes, and Clinical Outcomes.",2026,10.1245/s10434-026-19351-4,https://pubmed.ncbi.nlm.nih.gov/41826520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,42627772,Erratum.,2026,10.1159/000553551,https://pubmed.ncbi.nlm.nih.gov/42627772/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,41711158,Curing the “Incurable”: First Successful Hematopoietic Stem Cell Transplantation in Severe Hereditary Spherocytosis with Homozygous &lt;i&gt;SPTA1&lt;/i&gt; Variant and Hepatic Fibrosis,2026,10.4274/tjh.galenos.2026.04710,https://pubmed.ncbi.nlm.nih.gov/41711158/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,41868970,Lineage-Specific Disruption of Hematopoiesis by Oxaliplatin: Mechanisms of Erythropoietin Resistance and Immune Suppression.,2026,10.14302/issn.2372-6601.jhor-25-5944,https://pubmed.ncbi.nlm.nih.gov/41868970/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,41818007,A Low-complexity Programmable Ultrasound Stimulation System: Design and Safety Evaluation.,2026,10.1109/tbme.2026.3673152,https://pubmed.ncbi.nlm.nih.gov/41818007/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,39779891,Longitudinal genomic profiling using liquid biopsies in metastatic nonsquamous NSCLC following first line immunotherapy.,2025,10.1038/s41698-024-00797-2,https://pubmed.ncbi.nlm.nih.gov/39779891/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,42175794,Hereditary Spherocytosis: A Case Series Spanning Prenatal Detection to Neonatal Care.,2026,10.1002/pd.70185,https://pubmed.ncbi.nlm.nih.gov/42175794/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,41395625,Comprehensive molecular profiling of urologic tumors presented in a molecular tumor board: insights from a real-world precision oncology cohort.,2025,10.3389/fonc.2025.1688779,https://pubmed.ncbi.nlm.nih.gov/41395625/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,41855993,Multifactorial regulation of ultrasound-induced cavitation by engineered silica nanoparticles.,2026,10.1016/j.ultsonch.2026.107817,https://pubmed.ncbi.nlm.nih.gov/41855993/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,41841113,Ultrasonic exposure enhances the body's antioxidant capacity.,2026,10.3164/jcbn.25-210,https://pubmed.ncbi.nlm.nih.gov/41841113/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,39593786,Preliminary Examination of the Effects of Focused Ultrasound on Living Skin and Temperature at the Skin-Transducer Interface.,2024,10.3390/bioengineering11111126,https://pubmed.ncbi.nlm.nih.gov/39593786/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,36905103,Prognostic-Related Biomarkers in Pancreatic Ductal Adenocarcinoma Correlating with Immune Infiltrates Based on Proteomics.,2023,10.12659/msm.938785,https://pubmed.ncbi.nlm.nih.gov/36905103/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,41613154,Ideational and conceptual apraxia by cerebral infarction in the left basal ganglia and right pons: a case report.,2025,10.3389/fresc.2025.1723964,https://pubmed.ncbi.nlm.nih.gov/41613154/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SPTA1,ENSG00000163554,Unsafe,40580408,Genomic alteration correlates with programmed cell death ligand 1 (PD-L1) expression in 2750 Chinese non-small-cell lung cancer patients.,2026,10.1007/s12094-025-03966-2,https://pubmed.ncbi.nlm.nih.gov/40580408/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SRSF12,ENSG00000154548,Unsafe,41060796,SRSF12 is a primate-specific splicing factor that induces a tissue-specific gene expression program.,2025,10.1091/mbc.e25-07-0352,https://pubmed.ncbi.nlm.nih.gov/41060796/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SRSF12,ENSG00000154548,Unsafe,39986371,SRSF12 deficiency enhances tumor innervation and accelerates pancreatic tumorigenesis.,2025,10.1016/j.canlet.2025.217563,https://pubmed.ncbi.nlm.nih.gov/39986371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SRSF12,ENSG00000154548,Unsafe,39463061,SRSF12 is a prognostic biomarker involved in immune infiltration in acute myeloid leukemia.,2024,10.1080/16078454.2024.2420301,https://pubmed.ncbi.nlm.nih.gov/39463061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SRSF12,ENSG00000154548,Unsafe,40740009,Silencing serine/arginine-rich splicing factor 1 to induce apoptosis and autophagy-dependent cell death in cholangiocarcinoma through the correction of oncogenic splicing errors.,2025,10.5115/acb.25.052,https://pubmed.ncbi.nlm.nih.gov/40740009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SRSF12,ENSG00000154548,Unsafe,40239543,Putrescine modulates alternative splicing of gonadotropin hormone-releasing hormone (GnRH) through differential regulation of splicing factors.,2025,10.1016/j.bbrc.2025.151795,https://pubmed.ncbi.nlm.nih.gov/40239543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SRSF12,ENSG00000154548,Unsafe,37359548,Pro-inflammatory polarization and colorectal cancer modulate alternative and intronic polyadenylation in primary human macrophages.,2023,10.3389/fimmu.2023.1182525,https://pubmed.ncbi.nlm.nih.gov/37359548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SRSF12,ENSG00000154548,Unsafe,39251328,Regulatory interplay between SR proteins governs CLK1 kinase splice variants production.,2024,10.1261/rna.080107.124,https://pubmed.ncbi.nlm.nih.gov/39251328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SRSF12,ENSG00000154548,Unsafe,40781517,SRSF3 undergoes phase separation in lung cancer and is associated with immunity and ferroptosis.,2025,10.1038/s41598-025-12842-6,https://pubmed.ncbi.nlm.nih.gov/40781517/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SRSF12,ENSG00000154548,Unsafe,41638430,Phosphorylation-dependent regulation of serine/arginine-rich proteins and U2AF1 interactions in early spliceosome assembly.,2026,10.1016/j.jbc.2026.111222,https://pubmed.ncbi.nlm.nih.gov/41638430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SRSF12,ENSG00000154548,Unsafe,39227899,Exploring serine-arginine rich splicing factors: potential predictive markers for dysregulation in oral cancer.,2024,10.1186/s12885-024-12750-4,https://pubmed.ncbi.nlm.nih.gov/39227899/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SRSF12,ENSG00000154548,Unsafe,41916911,"[Expression, Prognostic and Functional Analysis of SRSF Family Proteins 
in Non-small Cell Lung Cancer].",2026,10.3779/j.issn.1009-3419.2026.106.02,https://pubmed.ncbi.nlm.nih.gov/41916911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SRSF12,ENSG00000154548,Unsafe,37020999,Using multi-tissue transcriptome-wide association study to identify candidate susceptibility genes for respiratory infectious diseases.,2023,10.3389/fgene.2023.1164274,https://pubmed.ncbi.nlm.nih.gov/37020999/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SRSF12,ENSG00000154548,Unsafe,34026613,Integrated Analysis of Nine Prognostic RNA-Binding Proteins in Soft Tissue Sarcoma.,2021,10.3389/fonc.2021.633024,https://pubmed.ncbi.nlm.nih.gov/34026613/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SRSF12,ENSG00000154548,Unsafe,25594558,SRrp35 suppresses cell proliferation and malignancy in hepatocellular carcinoma.,2015,10.1111/hepr.12493,https://pubmed.ncbi.nlm.nih.gov/25594558/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SRSF12,ENSG00000154548,Unsafe,32188628,Transcriptome complexity in intravascular NK/T-cell lymphoma.,2020,10.1136/jclinpath-2020-206461,https://pubmed.ncbi.nlm.nih.gov/32188628/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SRSF12,ENSG00000154548,Unsafe,11684676,Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing.,2001,10.1074/jbc.m103967200,https://pubmed.ncbi.nlm.nih.gov/11684676/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,41827805,MicroRNA-625-3p Increases Chemosensitivity in Ovarian Cancer Cells Through Decreasing SSX2IP-Mediated Cisplatin Export in Extracellular Vesicles.,2026,10.3390/cancers18050872,https://pubmed.ncbi.nlm.nih.gov/41827805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,39533770,SSX2IP promotes cell proliferation and migration in breast cancer by regulating FANCI.,2025,10.1002/cbin.12259,https://pubmed.ncbi.nlm.nih.gov/39533770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,39732885,Genome-wide analysis of alternative splicing differences in hepatic ischemia reperfusion injury.,2024,10.1038/s41598-024-82846-1,https://pubmed.ncbi.nlm.nih.gov/39732885/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,35658330,"MiRNA-181b-5p Modulates Cell Proliferation, Cell Cycle, and Apoptosis by Targeting &lt;i&gt;SSX2IP&lt;/i&gt; in Acute Lymphoblastic Leukemia",2022,10.4274/tjh.galenos.2022.2022.0054,https://pubmed.ncbi.nlm.nih.gov/35658330/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,36809789,Defining a cohort of anemia-activated cis elements reveals a mechanism promoting erythroid precursor function.,2023,10.1182/bloodadvances.2022009163,https://pubmed.ncbi.nlm.nih.gov/36809789/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,35406752,Mitotic Maturation Compensates for Premature Centrosome Splitting and PCM Loss in Human cep135 Knockout Cells.,2022,10.3390/cells11071189,https://pubmed.ncbi.nlm.nih.gov/35406752/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,34710136,Identification of the centrosomal maturation factor SSX2IP as a Wtip-binding partner by targeted proximity biotinylation.,2021,10.1371/journal.pone.0259068,https://pubmed.ncbi.nlm.nih.gov/34710136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,33987909,OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring.,2021,10.15252/embr.202052173,https://pubmed.ncbi.nlm.nih.gov/33987909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,36199443,CASP9 As a Prognostic Biomarker and Promising Drug Target Plays a Pivotal Role in Inflammatory Breast Cancer.,2022,10.1155/2022/1043445,https://pubmed.ncbi.nlm.nih.gov/36199443/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,37154991,Centrosome amplification-related signature correlated with immune microenvironment and treatment response predicts prognosis and improves diagnosis of hepatocellular carcinoma by integrating machine learning and single-cell analyses.,2024,10.1007/s12072-023-10538-5,https://pubmed.ncbi.nlm.nih.gov/37154991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,31837171,Expression and prognostic utility of SSX2IP in patients with nasopharyngeal carcinoma.,2020,10.1111/apm.13023,https://pubmed.ncbi.nlm.nih.gov/31837171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,32992503,Identification of Genes Whose Expression Overlaps Age Boundaries and Correlates with Risk Groups in Paediatric and Adult Acute Myeloid Leukaemia.,2020,10.3390/cancers12102769,https://pubmed.ncbi.nlm.nih.gov/32992503/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,29423088,Identification of survivin as a promising target for the immunotherapy of adult B-cell acute lymphoblastic leukemia.,2018,10.18632/oncotarget.23380,https://pubmed.ncbi.nlm.nih.gov/29423088/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,29658965,A comprehensive transcriptome analysis of skeletal muscles in two Polish pig breeds differing in fat and meat quality traits.,2018,10.1590/1678-4685-gmb-2016-0101,https://pubmed.ncbi.nlm.nih.gov/29658965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,26545777,The conserved Wdr8-hMsd1/SSX2IP complex localises to the centrosome and ensures proper spindle length and orientation.,2015,10.1016/j.bbrc.2015.10.169,https://pubmed.ncbi.nlm.nih.gov/26545777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,34140499,An anchoring complex recruits katanin for microtubule severing at the plant cortical nucleation sites.,2021,10.1038/s41467-021-24067-y,https://pubmed.ncbi.nlm.nih.gov/34140499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,30106160,Transcriptome and methylome profiling in a rat model of irritable bowel syndrome induced by stress.,2018,10.3892/ijmm.2018.3823,https://pubmed.ncbi.nlm.nih.gov/30106160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,25833712,Centriolar satellite- and hMsd1/SSX2IP-dependent microtubule anchoring is critical for centriole assembly.,2015,10.1091/mbc.e14-11-1561,https://pubmed.ncbi.nlm.nih.gov/25833712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,33789615,A novel tp53-associated nomogram to predict the overall survival in patients with pancreatic cancer.,2021,10.1186/s12885-021-08066-2,https://pubmed.ncbi.nlm.nih.gov/33789615/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,28098238,Expression of the novel maternal centrosome assembly factor Wdr8 is required for vertebrate embryonic mitoses.,2017,10.1038/ncomms14090,https://pubmed.ncbi.nlm.nih.gov/28098238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,23452395,SSX2IP promotes metastasis and chemotherapeutic resistance of hepatocellular carcinoma.,2013,10.1186/1479-5876-11-52,https://pubmed.ncbi.nlm.nih.gov/23452395/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,23826132,Epigenetic silencing of miR-338-3p contributes to tumorigenicity in gastric cancer by targeting SSX2IP.,2013,10.1371/journal.pone.0066782,https://pubmed.ncbi.nlm.nih.gov/23826132/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,17904521,SSX2IP: an emerging role in cancer.,2007,10.1016/j.bbrc.2007.09.052,https://pubmed.ncbi.nlm.nih.gov/17904521/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,19179477,Elevated expression of the leukemia-associated antigen SSX2IP predicts survival in acute myeloid leukemia patients who lack detectable cytogenetic rearrangements.,2009,10.1182/blood-2008-09-178848,https://pubmed.ncbi.nlm.nih.gov/19179477/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,16112646,Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia.,2005,10.1016/j.bbrc.2005.08.024,https://pubmed.ncbi.nlm.nih.gov/16112646/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,30881373,Identification of Important Effector Proteins in the FOXJ1 Transcriptional Network Associated With Ciliogenesis and Ciliary Function.,2019,10.3389/fgene.2019.00023,https://pubmed.ncbi.nlm.nih.gov/30881373/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,28430825,Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium.,2017,10.1371/journal.pgen.1006719,https://pubmed.ncbi.nlm.nih.gov/28430825/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SSX2IP,ENSG00000117155,Unsafe,25987607,The Msd1-Wdr8-Pkl1 complex anchors microtubule minus ends to fission yeast spindle pole bodies.,2015,10.1083/jcb.201412111,https://pubmed.ncbi.nlm.nih.gov/25987607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,42854377,Meiotic recombination proteins in cancer.,2026,10.1016/j.dnarep.2026.103963,https://pubmed.ncbi.nlm.nih.gov/42854377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,42051960,Meiotic gene expression of &lt;i&gt;STAG3&lt;/i&gt; and &lt;i&gt;DMC1&lt;/i&gt; in blood: A novel non-invasive biomarker approach for diminished ovarian reserve: A case-control study.,2026,10.18502/ijrm.v24i2.21050,https://pubmed.ncbi.nlm.nih.gov/42051960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,42399815,O-GlcNAc transferase governs spermatogenic mitotic-to-meiotic transition and progression by coordinating transcription and alternative splicing programs.,2026,10.1186/s11658-026-00972-2,https://pubmed.ncbi.nlm.nih.gov/42399815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,42857607,Roles of meiotic and mitotic cohesin in stem cell gene regulation and genome stability.,2026,10.1016/j.omtn.2026.103100,https://pubmed.ncbi.nlm.nih.gov/42857607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,41492387,STAG2-truncating variants reveal a mosaic STAG2 inactivation pattern and compensatory mechanisms involving cohesin complex remodeling.,2025,10.1016/j.isci.2025.114195,https://pubmed.ncbi.nlm.nih.gov/41492387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,41832298,Genomic sequencing of multicystic mesothelioma finds cohesin complex mutations associated with disease recurrence in patients referred for cytoreductive surgery and HIPEC.,2026,10.1038/s41416-026-03366-5,https://pubmed.ncbi.nlm.nih.gov/41832298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,42645331,Diverse Roles of Cohesin in Chromosome Dynamics and Stem Cells.,2026,10.3390/biotech15030070,https://pubmed.ncbi.nlm.nih.gov/42645331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,39932630,Novel STAG3 variant causes oligoasthenoteratozoospermia with high sperm aneuploidy rate.,2025,10.1007/s10815-025-03417-5,https://pubmed.ncbi.nlm.nih.gov/39932630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,41202953,Prenatal and postnatal exposure to environmental level arsenic declines male reproductive function by affecting spermatogenesis and maturation in offspring.,2026,10.1016/j.envres.2025.123276,https://pubmed.ncbi.nlm.nih.gov/41202953/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,41234874,Single-cell analysis of tumor microenvironment immune homeostasis and identification of prognostic biomarkers in head and neck squamous cell carcinoma.,2025,10.21037/tcr-2025-999,https://pubmed.ncbi.nlm.nih.gov/41234874/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,37828232,METTL3/IGF2BP2 axis affects the progression of colorectal cancer by regulating m6A modification of STAG3.,2023,10.1038/s41598-023-44379-x,https://pubmed.ncbi.nlm.nih.gov/37828232/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,41588333,Integrated analysis of lncRNA-miRNA-mRNA networks reveals stage-specific molecular regulation of oogenesis in Chinese alligator (Alligator sinensis).,2026,10.1186/s12864-026-12542-z,https://pubmed.ncbi.nlm.nih.gov/41588333/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,39030605,N6-methyladenosine writer METTL16-mediated alternative splicing and translation control are essential for murine spermatogenesis.,2024,10.1186/s13059-024-03332-5,https://pubmed.ncbi.nlm.nih.gov/39030605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,39999035,A Tiered Approach to Exome Sequencing Analysis in Early-Onset Primary Ovarian Insufficiency.,2025,10.1210/clinem/dgaf124,https://pubmed.ncbi.nlm.nih.gov/39999035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,38551023,mRNA-Seq of testis and liver tissues reveals a testis-specific gene and alternative splicing associated with hybrid male sterility in dzo.,2024,10.1093/jas/skae091,https://pubmed.ncbi.nlm.nih.gov/38551023/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,35768632,TCFL5 deficiency impairs the pachytene to diplotene transition during spermatogenesis in the mouse.,2022,10.1038/s41598-022-15167-w,https://pubmed.ncbi.nlm.nih.gov/35768632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,41393291,Novel variants associated with premature ovarian insufficiency in Russian adolescents.,2025,10.3389/fendo.2025.1687148,https://pubmed.ncbi.nlm.nih.gov/41393291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,39323031,Comprehensive Analysis Identifies Hyaluronan Mediated Motility Receptor and Cell Division Cycle 25C as Potential Prognostic Biomarkers in Head and Neck Squamous Cell Carcinoma.,2024,10.1177/10732748241287904,https://pubmed.ncbi.nlm.nih.gov/39323031/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,35941537,The upregulation of stromal antigen 3 expression suppresses the phenotypic hallmarks of hepatocellular carcinoma through the Smad3-CDK4/CDK6-cyclin D1 and CXCR4/RhoA pathways.,2022,10.1186/s12876-022-02400-z,https://pubmed.ncbi.nlm.nih.gov/35941537/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,37867192,SRSF2 is required for mRNA splicing during spermatogenesis.,2023,10.1186/s12915-023-01736-6,https://pubmed.ncbi.nlm.nih.gov/37867192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,31682730,Mutations in the stromal antigen 3 (STAG3) gene cause male infertility due to meiotic arrest.,2019,10.1093/humrep/dez204,https://pubmed.ncbi.nlm.nih.gov/31682730/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,36179046,Ectopic expression of meiotic cohesin generates chromosome instability in cancer cell line.,2022,10.1073/pnas.2204071119,https://pubmed.ncbi.nlm.nih.gov/36179046/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,33712015,Identification of four key prognostic genes and three potential drugs in human papillomavirus negative head and neck squamous cell carcinoma.,2021,10.1186/s12935-021-01863-6,https://pubmed.ncbi.nlm.nih.gov/33712015/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,31214493,The Ectopic Expression of Meiosis Regulatory Genes in Cutaneous T-Cell Lymphomas (CTCL).,2019,10.3389/fonc.2019.00429,https://pubmed.ncbi.nlm.nih.gov/31214493/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,34528236,Transcriptomic changes during stage progression of mycosis fungoides.,2022,10.1111/bjd.20760,https://pubmed.ncbi.nlm.nih.gov/34528236/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,27462861,Gene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors.,2016,10.18632/oncotarget.10788,https://pubmed.ncbi.nlm.nih.gov/27462861/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,26425700,"Diagnostic Performance of Plasma DNA Methylation Profiles in Lung Cancer, Pulmonary Fibrosis and COPD.",2015,10.1016/j.ebiom.2015.06.025,https://pubmed.ncbi.nlm.nih.gov/26425700/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,25408876,Cohesin complexes with a potential to link mammalian meiosis to cancer.,2013,10.1186/2045-9769-2-4,https://pubmed.ncbi.nlm.nih.gov/25408876/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,29757976,Fatty Acid β-Oxidation Is Essential in Leptin-Mediated Oocytes Maturation of Yellow Catfish Pelteobagrus fulvidraco.,2018,10.3390/ijms19051457,https://pubmed.ncbi.nlm.nih.gov/29757976/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,26243799,Genetics of primary ovarian insufficiency: new developments and opportunities.,2015,10.1093/humupd/dmv036,https://pubmed.ncbi.nlm.nih.gov/26243799/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAG3,ENSG00000066923,Unsafe,16401344,Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe.,2006,10.1186/1471-2407-6-6,https://pubmed.ncbi.nlm.nih.gov/16401344/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,42529575,Mining Chemotherapy Resistance Related Genes in Breast Cancer to Construct a New Prognosis Prediction Model-Based on GEO Database and Real-World Study.,2026,10.1155/humu/1378458,https://pubmed.ncbi.nlm.nih.gov/42529575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,41189944,Unveiling hypoxic regulatory networks by bioinformatics: mechanisms of hypoxia-related hub genes driving rituximab resistance and poor prognosis in DLBCL.,2025,10.3389/fonc.2025.1592441,https://pubmed.ncbi.nlm.nih.gov/41189944/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,42511095,Whole-Genome Resequencing-Based Selection-Signal and Association Analyses Prioritize Candidate Genes and Haplotypes for PRRS Resistance-Related Traits in Pigs.,2026,10.3390/ani16142218,https://pubmed.ncbi.nlm.nih.gov/42511095/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,37462801,Signal-transducing adaptor protein 1 (STAP1) in microglia promotes the malignant progression of glioma.,2023,10.1007/s11060-023-04390-8,https://pubmed.ncbi.nlm.nih.gov/37462801/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,36713363,Diagnostic and prognostic value of STAP1 and AHNAK methylation in peripheral blood immune cells for HBV-related hepatopathy.,2022,10.3389/fimmu.2022.1091103,https://pubmed.ncbi.nlm.nih.gov/36713363/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,37526444,Relationship between STAP1 methylation in peripheral blood T cells and the clinicopathological characteristics and prognosis of patients within 5-cm diameter HCC.,2024,10.23736/s2724-5985.23.03309-0,https://pubmed.ncbi.nlm.nih.gov/37526444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,37840707,StAP1 phage: an effective tool for treating methicillin-resistant Staphylococcus aureus infections.,2023,10.3389/fmicb.2023.1267786,https://pubmed.ncbi.nlm.nih.gov/37840707/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,40936767,Development of a prognostic RiskScore model using efferocytosis-related signature genes for lung adenocarcinoma.,2025,10.7717/peerj.19892,https://pubmed.ncbi.nlm.nih.gov/40936767/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,41192030,Lipidomics and transcriptomics analyses reveal high sperm storage ability-related lipids/genes in the liver-blood-utero-vaginal junction mucosa axis of female ducks.,2026,10.1016/j.theriogenology.2025.117743,https://pubmed.ncbi.nlm.nih.gov/41192030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,33228548,Mice lacking global Stap1 expression do not manifest hypercholesterolemia.,2020,10.1186/s12881-020-01176-x,https://pubmed.ncbi.nlm.nih.gov/33228548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,33159017,CircGLCE alleviates intervertebral disc degeneration by regulating apoptosis and matrix degradation through the targeting of miR-587/STAP1.,2020,10.18632/aging.104035,https://pubmed.ncbi.nlm.nih.gov/33159017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,31996024,Taking One Step Back in Familial Hypercholesterolemia: STAP1 Does Not Alter Plasma LDL (Low-Density Lipoprotein) Cholesterol in Mice and Humans.,2020,10.1161/atvbaha.119.313470,https://pubmed.ncbi.nlm.nih.gov/31996024/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,29330417,High STAP1 expression in DUX4-rearranged cases is not suitable as therapeutic target in pediatric B-cell precursor acute lymphoblastic leukemia.,2018,10.1038/s41598-017-17704-4,https://pubmed.ncbi.nlm.nih.gov/29330417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,38112449,Bioinformatics analyses and experimental validation of the role of phagocytosis in low-grade glioma.,2024,10.1002/tox.24095,https://pubmed.ncbi.nlm.nih.gov/38112449/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,40283609,A Novel Screening Approach for Familial Hypercholesterolemia: A Genetic Study on Patients Detected Using Preexisting Centralized Analytics.,2025,10.3390/jcm14082780,https://pubmed.ncbi.nlm.nih.gov/40283609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,39512369,Cardiovascular disease risk in patients with elevated LDL-C levels: FH vs. non-FH.,2024,10.3389/fcvm.2024.1434392,https://pubmed.ncbi.nlm.nih.gov/39512369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,35639605,A single promoter-TALE system for tissue-specific and tuneable expression of multiple genes in rice.,2022,10.1111/pbi.13864,https://pubmed.ncbi.nlm.nih.gov/35639605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,38529604,A Novel Gene Signature based on Immune Cell Infiltration Landscape Predicts Prognosis in Lung Adenocarcinoma Patients.,2024,10.2174/0109298673293174240320053546,https://pubmed.ncbi.nlm.nih.gov/38529604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,36685889,Positive regulation of innate immune response by miRNA-let-7a-5p.,2022,10.3389/fgene.2022.1025539,https://pubmed.ncbi.nlm.nih.gov/36685889/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,31427613,Evaluation of the role of STAP1 in Familial Hypercholesterolemia.,2019,10.1038/s41598-019-48402-y,https://pubmed.ncbi.nlm.nih.gov/31427613/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,36439494,Characterization of genomic alterations and neoantigens and analysis of immune infiltration identified therapeutic and prognostic biomarkers in adenocarcinoma at the gastroesophageal junction.,2022,10.3389/fonc.2022.941868,https://pubmed.ncbi.nlm.nih.gov/36439494/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,34108619,A risk model developed based on tumor microenvironment predicts overall survival and associates with tumor immunity of patients with lung adenocarcinoma.,2021,10.1038/s41388-021-01853-y,https://pubmed.ncbi.nlm.nih.gov/34108619/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,28324178,Complete genome sequence analysis of a novel Staphylococcus phage StAP1 and proposal of a new species in the genus Silviavirus.,2017,10.1007/s00705-017-3316-2,https://pubmed.ncbi.nlm.nih.gov/28324178/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,35581549,Genome-wide detection of genetic structure and runs of homozygosity analysis in Anhui indigenous and Western commercial pig breeds using PorcineSNP80k data.,2022,10.1186/s12864-022-08583-9,https://pubmed.ncbi.nlm.nih.gov/35581549/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,33280515,The Lung Adenocarcinoma Microenvironment Mining and Its Prognostic Merit.,2020,10.1177/1533033820977547,https://pubmed.ncbi.nlm.nih.gov/33280515/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,34712245,Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period.,2021,10.3389/fimmu.2021.763067,https://pubmed.ncbi.nlm.nih.gov/34712245/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,33498209,Reticular Basement Membrane Thickness Is Associated with Growth- and Fibrosis-Promoting Airway Transcriptome Profile-Study in Asthma Patients.,2021,10.3390/ijms22030998,https://pubmed.ncbi.nlm.nih.gov/33498209/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,33102522,Identification of a Novel Tumor Microenvironment-Associated Eight-Gene Signature for Prognosis Prediction in Lung Adenocarcinoma.,2020,10.3389/fmolb.2020.571641,https://pubmed.ncbi.nlm.nih.gov/33102522/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,10518561,"Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase.",1999,10.1073/pnas.96.21.11976,https://pubmed.ncbi.nlm.nih.gov/10518561/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,23269450,Mucosal plasma cell barrier disruption during intestine transplant rejection.,2012,10.1097/tp.0b013e3182708d9d,https://pubmed.ncbi.nlm.nih.gov/23269450/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,20442417,Loops govern SH2 domain specificity by controlling access to binding pockets.,2010,10.1126/scisignal.2000796,https://pubmed.ncbi.nlm.nih.gov/20442417/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STAP1,ENSG00000035720,Unsafe,17509582,Potato aspartic proteases (StAPs) exert cytotoxic activity on bovine and human spermatozoa.,2007,10.1016/j.fertnstert.2007.02.008,https://pubmed.ncbi.nlm.nih.gov/17509582/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STEAP1B,ENSG00000105889,Unsafe,36011027,STEAP1-4 (Six-Transmembrane Epithelial Antigen of the Prostate 1-4) and Their Clinical Implications for Prostate Cancer.,2022,10.3390/cancers14164034,https://pubmed.ncbi.nlm.nih.gov/36011027/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STEAP1B,ENSG00000105889,Unsafe,34778263,Regulatory Roles of Six-Transmembrane Epithelial Antigen of the Prostate Family Members in the Occurrence and Development of Malignant Tumors.,2021,10.3389/fcell.2021.752426,https://pubmed.ncbi.nlm.nih.gov/34778263/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STEAP1B,ENSG00000105889,Unsafe,36183486,Whole genome sequencing identifies candidate genes for familial essential tremor and reveals biological pathways implicated in essential tremor aetiology.,2022,10.1016/j.ebiom.2022.104290,https://pubmed.ncbi.nlm.nih.gov/36183486/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STEAP1B,ENSG00000105889,Unsafe,32277301,Genome-wide association study identifies new loci for albuminuria in the Japanese population.,2020,10.1007/s10157-020-01884-x,https://pubmed.ncbi.nlm.nih.gov/32277301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STEAP1B,ENSG00000105889,Unsafe,25053991,"Expression of STEAP1 and STEAP1B in prostate cell lines, and the putative regulation of STEAP1 by post-transcriptional and post-translational mechanisms.",2014,10.18632/genesandcancer.13,https://pubmed.ncbi.nlm.nih.gov/25053991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,41785206,Transcriptional repression of reaper by Stand still ensures female germline development in Drosophila.,2026,10.1371/journal.pgen.1012041,https://pubmed.ncbi.nlm.nih.gov/41785206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,42009739,Multi-omics analysis reveals the key role of STIL in Li-Fraumeni syndrome and osteosarcoma.,2026,10.1038/s41698-026-01432-y,https://pubmed.ncbi.nlm.nih.gov/42009739/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,40907573,"H3K18la Facilitates TRA2A-Mediated Alternative Splicing of STIL, Suppressing Ferroptosis and Cisplatin Treatment Sensitivity in Ovarian Cancer.",2026,10.4143/crt.2025.752,https://pubmed.ncbi.nlm.nih.gov/40907573/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,42050492,Association of stromal tumor infiltrating lymphocytes and body mass index with prognosis in esophageal squamous cell carcinoma patients.,2026,10.1186/s12885-026-16045-8,https://pubmed.ncbi.nlm.nih.gov/42050492/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,42679176,Folate Receptor Alpha Expression Across the Spectrum of Serous Tubal Lesions: An Adjunct Biomarker for Distinguishing Serous Tubal Intraepithelial Carcinoma From Serous Tubal Intraepithelial Lesions.,2026,10.1097/pas.0000000000002612,https://pubmed.ncbi.nlm.nih.gov/42679176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,42252253,Tubal epithelial alterations: evolving concepts.,2026,10.3802/jgo.2026.37.e121,https://pubmed.ncbi.nlm.nih.gov/42252253/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,41749477,Disrupted STIL-BRCA1 axis causes centrosome amplification and genomic instability.,2026,10.1002/1873-3468.70317,https://pubmed.ncbi.nlm.nih.gov/41749477/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,42195079,Comparison of Stromal Tumor-Infiltrating Lymphocyte (sTIL) Levels and Clinicopathological Features in Neoadjuvant-Naive HER2-Low and HER2-Negative Primary Breast Cancers.,2026,10.3390/medicina62050826,https://pubmed.ncbi.nlm.nih.gov/42195079/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,42636839,Artificial intelligence-based tumour infiltrating lymphocyte quantification in patients with triple-negative breast cancer: an independent validation study.,2026,10.1016/s1470-2045(26)00339-6,https://pubmed.ncbi.nlm.nih.gov/42636839/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,41720822,Clinical and histopathological characterization of metastatic lobular breast cancer: lessons learned from post-mortem tissue donation programs.,2026,10.1038/s41523-026-00912-5,https://pubmed.ncbi.nlm.nih.gov/41720822/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,41453690,FBXW7 E3 ligase prevents centriole overduplication by degrading the Plk4 phosphorylated STIL-SAS6 cartwheel assembly.,2026,10.1016/j.jbc.2025.111104,https://pubmed.ncbi.nlm.nih.gov/41453690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,42082707,Artificial intelligence-powered H&amp;E-based quantification of spatial tumor-infiltrating lymphocyte distribution identifies prognostic immune niches in colorectal cancer.,2026,10.1007/s00262-026-04409-9,https://pubmed.ncbi.nlm.nih.gov/42082707/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,39466849,STIL overexpression shortens lifespan and reduces tumor formation in mice.,2024,10.1371/journal.pgen.1011460,https://pubmed.ncbi.nlm.nih.gov/39466849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,42389652,Tuberculous pyosalpinx associated with serous tubal intraepithelial lesion: a case report on evidence of early tubal neoplastic transformation.,2026,10.1016/j.crwh.2026.e00828,https://pubmed.ncbi.nlm.nih.gov/42389652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,41943585,Comparative Analysis of Stromal Tumor Infiltrating Lymphocytes in Various Grades and Molecular Subtypes of Breast Carcinoma.,2026,10.4103/aam.aam_873_25,https://pubmed.ncbi.nlm.nih.gov/41943585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,41972153,Clinicopathological and molecular characteristics associated with pathological complete response in neoadjuvant immunotherapy for breast cancer.,2026,10.3389/fimmu.2026.1771228,https://pubmed.ncbi.nlm.nih.gov/41972153/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,42337235,Spatial analyses implicate high stromal tumour-infiltrating CD8&lt;sup&gt;+&lt;/sup&gt; lymphocytes as a negative predictive marker for chemotherapy in estrogen receptor-positive breast cancer.,2026,10.1038/s41467-026-73432-2,https://pubmed.ncbi.nlm.nih.gov/42337235/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,39735672,STIL enhances the development of lung adenocarcinoma by regulating the glycolysis pathway.,2025,10.32604/or.2024.048562,https://pubmed.ncbi.nlm.nih.gov/39735672/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,39718123,Regulatory factor X-5/SCL/TAL1 interruption site axis promotes aerobic glycolysis and hepatocellular carcinoma cell stemness.,2025,10.1002/kjm2.12922,https://pubmed.ncbi.nlm.nih.gov/39718123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,40861467,Heterogeneity and distribution characteristics of tertiary lymphoid structures predict prognostic outcome in esophageal squamous cell carcinoma.,2025,10.3389/fimmu.2025.1606499,https://pubmed.ncbi.nlm.nih.gov/40861467/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,42636838,"Manual, digital, and AI tumour-infiltrating lymphocyte scoring: a secondary analysis of the APHINITY randomised trial.",2026,10.1016/s1470-2045(26)00247-0,https://pubmed.ncbi.nlm.nih.gov/42636838/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,40021215,T-cell immune checkpoint inhibition plus hypomethylation for locally advanced HER2-negative breast cancer: a phase 2 neoadjuvant window trial of decitabine and pembrolizumab followed by standard neoadjuvant chemotherapy.,2025,10.1136/jitc-2024-010294,https://pubmed.ncbi.nlm.nih.gov/40021215/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,42512390,Prognostic Value of Morphological Characteristics and Immune Microenvironment in High-Grade Serous Cancer (HGSC).,2026,10.3390/cancers18142327,https://pubmed.ncbi.nlm.nih.gov/42512390/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,42617026,Tumor-infiltrating lymphocytes density and distribution in breast cancer: A two-year study on their clinicopathological correlation.,2026,10.4103/jcrt.jcrt_1656_25,https://pubmed.ncbi.nlm.nih.gov/42617026/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,41234834,Clinical significance of CD155 expression and correlation with immune cell infiltration in triple-negative breast cancer.,2025,10.21037/tcr-2025-643,https://pubmed.ncbi.nlm.nih.gov/41234834/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,41698306,"Analgesic efficacy of the subtransverse process interligamentary plane block in thoracic surgery: A randomized, controlled, non-inferiority trial.",2026,10.1016/j.jclinane.2026.112149,https://pubmed.ncbi.nlm.nih.gov/41698306/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,41696397,"Comment on ""Ultrasound-guided subtransverse interligamentary (STIL) block versus erector spinae plane (ESP) block for postoperative analgesia in patients undergoing modified radical mastectomy (MRM)"".",2026,10.4103/ija.ija_1049_25,https://pubmed.ncbi.nlm.nih.gov/41696397/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,40114292,"Pathological complete response, histologic grade, and level of stromal tumor-infiltrating lymphocytes in ER + HER2- breast cancer.",2025,10.1186/s13058-025-01999-7,https://pubmed.ncbi.nlm.nih.gov/40114292/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,41696383,"Reply to ""Ultrasound-guided sub transverse interligamentary (STIL) block versus erector spinae plane (ESP) block for postoperative analgesia in patients undergoing modified radical mastectomy (MRM)"".",2026,10.4103/ija.ija_1273_25,https://pubmed.ncbi.nlm.nih.gov/41696383/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,41716408,Adjuvant pegylated liposomal doxorubicin versus epirubicin sequential paclitaxel in triple-negative breast cancer: comparable efficacy with a distinct safety profile.,2026,10.3389/fimmu.2026.1690888,https://pubmed.ncbi.nlm.nih.gov/41716408/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,38547391,Tumor-infiltrating lymphocytes and breast cancer mortality in racially and ethnically diverse participants of the Northern California Breast Cancer Family Registry.,2024,10.1093/jncics/pkae023,https://pubmed.ncbi.nlm.nih.gov/38547391/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,15107824,Sil overexpression in lung cancer characterizes tumors with increased mitotic activity.,2004,10.1038/sj.onc.1207685,https://pubmed.ncbi.nlm.nih.gov/15107824/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STIL,ENSG00000123473,Unsafe,1922059,"Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia.",1991,10.1128/mcb.11.11.5462-5469.1991,https://pubmed.ncbi.nlm.nih.gov/1922059/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,42710668,STK31 enhances gallbladder cancer development by modulating DNA replication machinery.,2026,10.1016/j.jbc.2026.113534,https://pubmed.ncbi.nlm.nih.gov/42710668/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,42281281,ω-3PUFAs Inhibit Gallbladder Cancer Through Enhancing STK31 Methylation.,2026,10.1002/mnfr.70522,https://pubmed.ncbi.nlm.nih.gov/42281281/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,41275291,NSUN7-mediated m&lt;sup&gt;5&lt;/sup&gt;C modification of circNTRK2 regulates stemness properties of glioblastoma cells by activating STK31.,2025,10.1186/s12967-025-07484-1,https://pubmed.ncbi.nlm.nih.gov/41275291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,42038776,Association of Circular RNAs with Sperm Fertility Potential: Implications for Male Infertility Diagnosis.,2025,10.18502/jri.v26i4.21087,https://pubmed.ncbi.nlm.nih.gov/42038776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,40688336,Identification and validation of a prognostic signature of m&lt;sup&gt;5&lt;/sup&gt;C-related genes for esophageal cancer.,2025,10.21037/jtd-2025-768,https://pubmed.ncbi.nlm.nih.gov/40688336/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,39054797,The molecular mechanism underlying KRAS regulation on STK31 expression in pancreatic ductal adenocarcinoma.,2024,10.1111/cas.16286,https://pubmed.ncbi.nlm.nih.gov/39054797/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,36424885,Cancer-testis gene STK31 is regulated by methylation and promotes the development of pancreatic cancer.,2023,10.1002/cam4.5472,https://pubmed.ncbi.nlm.nih.gov/36424885/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,40025230,STK31 drives tumor immune evasion through STAT3-IL-6 mediated CD8&lt;sup&gt;+&lt;/sup&gt; T cell exhaustion.,2025,10.1038/s41388-024-03271-2,https://pubmed.ncbi.nlm.nih.gov/40025230/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,41324770,Whole-exome sequencing for identification of specific gene mutations in an Indian cohort of triple-negative breast cancer patients.,2025,10.1007/s12672-025-03921-1,https://pubmed.ncbi.nlm.nih.gov/41324770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,36636045,MicroRNA-543 controls pancreatic cancer development by LINC00847-microRNA-543-STK31 axis.,2022,10.21037/jgo-22-1017,https://pubmed.ncbi.nlm.nih.gov/36636045/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,33649810,STK31 upregulation is associated with chromatin remodeling in gastric cancer and induction of tumorigenicity in a xenograft mouse model.,2021,10.3892/or.2021.7993,https://pubmed.ncbi.nlm.nih.gov/33649810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,40332359,Single-Cell Transcriptomic Analysis of the Potential Mechanisms of Follicular Development in &lt;i&gt;Stra8&lt;/i&gt;-Deficient Mice.,2025,10.3390/ijms26083734,https://pubmed.ncbi.nlm.nih.gov/40332359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,35389570,Spastic Paraplegia 20 and Serine/Threonine Protein Kinase 31 Expression for the Detection of Colorectal Cancer.,2022,10.33594/000000509,https://pubmed.ncbi.nlm.nih.gov/35389570/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,37194006,Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice.,2023,10.1186/s12958-023-01097-3,https://pubmed.ncbi.nlm.nih.gov/37194006/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,39031522,Rare and common variants associated with alcohol consumption identify a conserved molecular network.,2024,10.1111/acer.15399,https://pubmed.ncbi.nlm.nih.gov/39031522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,31894338,STK31 regulates the proliferation and cell cycle of lung cancer cells via the Wnt/β‑catenin pathway and feedback regulation by c‑myc.,2020,10.3892/or.2019.7441,https://pubmed.ncbi.nlm.nih.gov/31894338/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,28412729,STK31 as novel biomarker of metastatic potential and tumorigenicity of colorectal cancer.,2017,10.18632/oncotarget.15396,https://pubmed.ncbi.nlm.nih.gov/28412729/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,27852984,Characterization of MAGEG2 with testis-specific expression in mice.,2017,10.4103/1008-682x.192033,https://pubmed.ncbi.nlm.nih.gov/27852984/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,33128354,Higher miR-543 levels correlate with lower STK31 expression and longer pancreatic cancer survival.,2020,10.1002/cam4.3559,https://pubmed.ncbi.nlm.nih.gov/33128354/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,28422722,"The clinical value, regulatory mechanisms, and gene network of the cancer-testis gene STK31 in pancreatic cancer.",2017,10.18632/oncotarget.16814,https://pubmed.ncbi.nlm.nih.gov/28422722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,32053966,Ductal Carcinoma In Situ Progression in Dog Model of Breast Cancer.,2020,10.3390/cancers12020418,https://pubmed.ncbi.nlm.nih.gov/32053966/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,24667656,STK31 is a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells.,2014,10.1371/journal.pone.0093303,https://pubmed.ncbi.nlm.nih.gov/24667656/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,24586802,"STK31/TDRD8, a germ cell-specific factor, is dispensable for reproduction in mice.",2014,10.1371/journal.pone.0089471,https://pubmed.ncbi.nlm.nih.gov/24586802/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,31706243,Low doses of carbendazim and chlorothalonil synergized to impair mouse spermatogenesis through epigenetic pathways.,2020,10.1016/j.ecoenv.2019.109908,https://pubmed.ncbi.nlm.nih.gov/31706243/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,18281482,Efficient identification of a novel cancer/testis antigen for immunotherapy using three-step microarray analysis.,2008,10.1158/0008-5472.can-07-0964,https://pubmed.ncbi.nlm.nih.gov/18281482/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STK31,ENSG00000196335,Unsafe,23483634,Transcriptomic Profiling of Medial Temporal Lobe Epilepsy.,2012,10.4172/jpb.1000210,https://pubmed.ncbi.nlm.nih.gov/23483634/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STPG3,ENSG00000197768,Unsafe,41829019,"Whole-Genome Sequencing Reveals Breed-Specific SNPs, Indels, and Signatures of Selection in Royal White and White Dorper Sheep.",2026,10.3390/ani16050811,https://pubmed.ncbi.nlm.nih.gov/41829019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STPG3,ENSG00000197768,Unsafe,32561905,CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity.,2020,10.1093/biolre/ioaa084,https://pubmed.ncbi.nlm.nih.gov/32561905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STPG3,ENSG00000197768,Unsafe,36717792,Novel cuproptosis-related long non-coding RNA signature to predict prognosis in prostate carcinoma.,2023,10.1186/s12885-023-10584-0,https://pubmed.ncbi.nlm.nih.gov/36717792/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STPG3,ENSG00000197768,Unsafe,35018112,Long Non-Coding RNA Signatures Associated with Ferroptosis Predict Prognosis in Colorectal Cancer.,2022,10.2147/ijgm.s331378,https://pubmed.ncbi.nlm.nih.gov/35018112/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STPG3,ENSG00000197768,Unsafe,26956253,Mosaic CREBBP mutation causes overlapping clinical features of Rubinstein-Taybi and Filippi syndromes.,2016,10.1038/ejhg.2016.14,https://pubmed.ncbi.nlm.nih.gov/26956253/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,41962458,Isoform-dependent glycosylation of respiratory viral class I fusion glycoproteins by oligosaccharyltransferases.,2026,10.1016/j.virol.2026.110902,https://pubmed.ncbi.nlm.nih.gov/41962458/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,41778789,Differential contributions of human oligosaccharyltransferase complexes OST-A and OST-B to HIV-1 envelope glycoprotein glycosylation.,2026,10.1128/jvi.01481-25,https://pubmed.ncbi.nlm.nih.gov/41778789/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,41574665,HMGN2 induces pyroptosis in tumour cells by modulating the STT3B/PD‑L1/caspase‑1/GSDMD axis.,2026,10.3892/mmr.2026.13807,https://pubmed.ncbi.nlm.nih.gov/41574665/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,42499505,Posaconazole mitigates α-amanitin-induced liver injury by inhibiting STT3B-mediated glycosylation and cellular uptake.,2026,10.3389/fphar.2026.1864484,https://pubmed.ncbi.nlm.nih.gov/42499505/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,42610776,Design of absorbing material distribution for noise barrier via accelerated BEM and optimality criteria method.,2026,10.1177/00368504261480232,https://pubmed.ncbi.nlm.nih.gov/42610776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,42636657,STT3 promotes cervical cancer proliferation and apoptosis via PI3K/AKT pathway.,2026,10.1016/j.tranon.2026.102991,https://pubmed.ncbi.nlm.nih.gov/42636657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,42680959,The lithium-magnesium-zinc axis under stress: regulation of N-glycosylation-linked proteostasis and Alzheimer's disease.,2026,10.1007/s10787-026-02383-3,https://pubmed.ncbi.nlm.nih.gov/42680959/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,41757822,A comparison of simplified versus the original media in standard vapor freezing and in-house vitrification of human sperm.,2026,10.5935/1518-0557.20250154,https://pubmed.ncbi.nlm.nih.gov/41757822/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,39732974,Hypoxia-induced TPC2 transcription and glycosylation aggravates pulmonary arterial hypertension by blocking autophagy flux.,2024,10.1038/s41598-024-82552-y,https://pubmed.ncbi.nlm.nih.gov/39732974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,40056505,Unveiling the Role of Oligosaccharyltransferase STT3B in Colorectal Cancer Tissues: Clinical significance and Molecular Mechanisms Driving the Formation of Tertiary Lymphoid Structures.,2025,10.1016/j.imbio.2025.152886,https://pubmed.ncbi.nlm.nih.gov/40056505/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,41217233,Glycosylation of Tetraspanin CD151 Defines the Invasive Phenotype of Human Breast Cancer Cells.,2025,10.1096/fj.202500093r,https://pubmed.ncbi.nlm.nih.gov/41217233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,39945486,STT3B promotes porcine epidemic diarrhea virus replication by regulating N-glycosylation of PEDV S protein.,2025,10.1128/jvi.00018-25,https://pubmed.ncbi.nlm.nih.gov/39945486/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,39192160,Exosomes from Hypoxic Pretreatment ADSCs Ameliorate Cardiac Damage Post-MI via Activated circ-Stt3b/miR-15a-5p/GPX4 Signaling and Decreased Ferroptosis.,2024,10.1007/s12012-024-09915-9,https://pubmed.ncbi.nlm.nih.gov/39192160/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,38934375,Acceptors stability modulates the efficiency of post-translational protein N-glycosylation.,2024,10.1096/fj.202302267r,https://pubmed.ncbi.nlm.nih.gov/38934375/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,38945975,Stabilization of EREG via STT3B-mediated N-glycosylation is critical for PDL1 upregulation and immune evasion in head and neck squamous cell carcinoma.,2024,10.1038/s41368-024-00311-1,https://pubmed.ncbi.nlm.nih.gov/38945975/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,40494352,Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation.,2025,10.1016/j.chembiol.2025.05.005,https://pubmed.ncbi.nlm.nih.gov/40494352/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,42680017,Genome-wide screening and functional analysis of protein glycosylation-related genes involved in tomato fruit ripening.,2026,10.1016/j.plantsci.2026.113418,https://pubmed.ncbi.nlm.nih.gov/42680017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,40343924,Design of the multi-material structure using an MMC-SIMP sequential topology optimization method.,2025,10.1371/journal.pone.0321100,https://pubmed.ncbi.nlm.nih.gov/40343924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,39668180,STT3-mediated aberrant N-glycosylation of CD24 inhibits paclitaxel sensitivity in triple-negative breast cancer.,2025,10.1038/s41401-024-01419-0,https://pubmed.ncbi.nlm.nih.gov/39668180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,39118819,The rhythmic mind: brain functions of percussionists in improvisation.,2024,10.3389/fnhum.2024.1418727,https://pubmed.ncbi.nlm.nih.gov/39118819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,42513682,Effect of Manual Tungsten Inert Gas Welding on the Microstructure and Mechanical Properties of Welded Joints in Thick SIMP Steel Plates.,2026,10.3390/ma19142944,https://pubmed.ncbi.nlm.nih.gov/42513682/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,42009876,In vitro tolerability of soluble silicic acid and tetraethyl orthosilicate in ocular epithelial cells.,2026,10.1007/s10856-026-07048-9,https://pubmed.ncbi.nlm.nih.gov/42009876/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,40778492,Feasibility and Safety of Transfemoral Aortic Valve Replacement Using Local Anesthesia in the Catheterization Suite Versus General Anesthesia in the Operation Theater.,2025,10.1002/ccd.70084,https://pubmed.ncbi.nlm.nih.gov/40778492/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,40093315,Development and validation of a prediction model for VTE risk in gastric and esophageal cancer patients.,2025,10.3389/fphar.2025.1448879,https://pubmed.ncbi.nlm.nih.gov/40093315/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,39830021,A novel allosteric driver mutation of β-glucuronidase promotes head and neck squamous cell carcinoma progression through STT3B-mediated PD-L1 N-glycosylation.,2025,10.1002/mco2.70062,https://pubmed.ncbi.nlm.nih.gov/39830021/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,40237362,Covalently Interlocked Electrode-Electrolyte Interface for High-Energy-Density Quasi-Solid-State Lithium-Ion Batteries.,2025,10.1002/advs.202417143,https://pubmed.ncbi.nlm.nih.gov/40237362/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,41471498,Design and Testing of an Emg-Controlled Semi-Active Knee Prosthesis.,2025,10.3390/s25247505,https://pubmed.ncbi.nlm.nih.gov/41471498/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,39047576,Evaluation of enhanced external counterpulsation for diabetic foot based on a patient-specific 0D-1D cardiovascular system model.,2024,10.1016/j.cmpb.2024.108333,https://pubmed.ncbi.nlm.nih.gov/39047576/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STT3B,ENSG00000163527,Unsafe,12887896,Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties.,2003,10.1016/s1097-2765(03)00243-0,https://pubmed.ncbi.nlm.nih.gov/12887896/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,40593136,Role of lysine acetylation-related genes in the diagnosis and prognosis of glioma.,2025,10.1038/s41598-025-07738-4,https://pubmed.ncbi.nlm.nih.gov/40593136/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,40691474,LARS2 DNA methylation predicts the prognosis in colon cancer.,2025,10.1038/s41598-025-10669-9,https://pubmed.ncbi.nlm.nih.gov/40691474/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,40713775,"Reversing the ""cold"" tumor microenvironment: the role of neoantigen vaccines in prostate cancer.",2025,10.1186/s12967-025-06867-8,https://pubmed.ncbi.nlm.nih.gov/40713775/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,39326207,Chronic lung inflammation and CK14+ basal cell proliferation induce persistent alveolar-bronchiolization in SARS-CoV-2-infected hamsters.,2024,10.1016/j.ebiom.2024.105363,https://pubmed.ncbi.nlm.nih.gov/39326207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,32993587,"Distinctive roles of syntaxin binding protein 4 and its action target, TP63, in lung squamous cell carcinoma: a theranostic study for the precision medicine.",2020,10.1186/s12885-020-07448-2,https://pubmed.ncbi.nlm.nih.gov/32993587/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,36291149,"RNA Sequencing of Intestinal Enterocytes Pre- and Post-Roux-en-Y Gastric Bypass Reveals Alteration in Gene Expression Related to Enterocyte Differentiation, Restitution, and Obesity with Regulation by Schlafen 12.",2022,10.3390/cells11203283,https://pubmed.ncbi.nlm.nih.gov/36291149/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,35772352,Germline allelic expression of genes at 17q22 locus associates with risk of breast cancer.,2022,10.1016/j.ejca.2022.05.034,https://pubmed.ncbi.nlm.nih.gov/35772352/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,31782549,Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor.,2020,10.15252/embj.2019102406,https://pubmed.ncbi.nlm.nih.gov/31782549/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,29735662,STXBP4 regulates APC/C-mediated p63 turnover and drives squamous cell carcinogenesis.,2018,10.1073/pnas.1718546115,https://pubmed.ncbi.nlm.nih.gov/29735662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,28087642,STXBP4 Drives Tumor Growth and Is Associated with Poor Prognosis through PDGF Receptor Signaling in Lung Squamous Cell Carcinoma.,2017,10.1158/1078-0432.ccr-16-1815,https://pubmed.ncbi.nlm.nih.gov/28087642/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,35389339,Genetic loci and metabolic states associated with murine epigenetic aging.,2022,10.7554/elife.75244,https://pubmed.ncbi.nlm.nih.gov/35389339/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,35585482,Sperm DNA methylation patterns at discrete CpGs and genes involved in embryonic development are related to bull fertility.,2022,10.1186/s12864-022-08614-5,https://pubmed.ncbi.nlm.nih.gov/35585482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,36496815,Assessment and Distribution of Runs of Homozygosity in Horse Breeds Representing Different Utility Types.,2022,10.3390/ani12233293,https://pubmed.ncbi.nlm.nih.gov/36496815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,31539133,Long noncoding RNA LINC00511 involves in breast cancer recurrence and radioresistance by regulating STXBP4 expression via miR-185.,2019,10.26355/eurrev_201909_18855,https://pubmed.ncbi.nlm.nih.gov/31539133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,41059755,Retraction Note.,2025,10.26355/eurrev_202509_37398,https://pubmed.ncbi.nlm.nih.gov/41059755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,27600471,"Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs).",2016,10.1038/srep32512,https://pubmed.ncbi.nlm.nih.gov/27600471/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,32115800,Transcriptome-wide association study of breast cancer risk by estrogen-receptor status.,2020,10.1002/gepi.22288,https://pubmed.ncbi.nlm.nih.gov/32115800/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,26472073,Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors.,2015,10.1093/hmg/ddv432,https://pubmed.ncbi.nlm.nih.gov/26472073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,19451233,Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation.,2009,10.1128/mcb.00449-09,https://pubmed.ncbi.nlm.nih.gov/19451233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,26895964,Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin.,2016,10.1074/jbc.m115.674200,https://pubmed.ncbi.nlm.nih.gov/26895964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP4,ENSG00000166263,Unsafe,23893088,"The associations between a polygenic score, reproductive and menstrual risk factors and breast cancer risk.",2013,10.1007/s10549-013-2646-3,https://pubmed.ncbi.nlm.nih.gov/23893088/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,42443147,Mapping lncRNAs onto multilevel mRNA co‑expression modules in autism.,2026,10.1038/s41398-026-04275-0,https://pubmed.ncbi.nlm.nih.gov/42443147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,41273056,Adolescent White Matter Maturation Mediates Epigenetic Associations With Cognitive Development.,2026,10.1002/dneu.70000,https://pubmed.ncbi.nlm.nih.gov/41273056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,39379476,The syntaxin-binding protein STXBP5 regulates progerin expression.,2024,10.1038/s41598-024-74621-z,https://pubmed.ncbi.nlm.nih.gov/39379476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,40274928,Author Correction: The syntaxin-binding protein STXBP5 regulates progerin expression.,2025,10.1038/s41598-025-96183-4,https://pubmed.ncbi.nlm.nih.gov/40274928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,42441516,Machine Learning-Based Identification of Tamoxifen Resistance-Associated Genes and Their Application in Prognostic Modeling of Breast Cancer.,2026,10.3791/71327,https://pubmed.ncbi.nlm.nih.gov/42441516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,37325053,Comprehensive investigation of the prognostic values and molecular mechanisms of syntaxin binding protein 5 antisense RNA 1 in patients with colon adenocarcinoma based on RNA sequencing dataset.,2023,10.7150/jca.83423,https://pubmed.ncbi.nlm.nih.gov/37325053/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,42340073,"Platelet-Related Gene Signature Predicts Prognosis, Immune Landscape, and Drug Sensitivity in Acute Myeloid Leukemia.",2026,10.1002/biof.70123,https://pubmed.ncbi.nlm.nih.gov/42340073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,41732097,Transcriptome profiling of peripheral blood for inflammatory subtype classification and diagnostic model construction in asthma.,2026,10.1080/02770903.2026.2633354,https://pubmed.ncbi.nlm.nih.gov/41732097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,37695731,Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons.,2023,10.7554/elife.85561,https://pubmed.ncbi.nlm.nih.gov/37695731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,37529779,Epigenetic associations with adolescent grey matter maturation and cognitive development.,2023,10.3389/fgene.2023.1222619,https://pubmed.ncbi.nlm.nih.gov/37529779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,33965377,Aberrant hypermethylation induced downregulation of antisense lncRNA STXBP5-AS1 and its sense gene STXBP5 correlate with tumorigenesis of glioma.,2021,10.1016/j.lfs.2021.119590,https://pubmed.ncbi.nlm.nih.gov/33965377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,34764730,Ginsenoside Rh2 upregulates long noncoding RNA STXBP5-AS1 to sponge microRNA-4425 in suppressing breast cancer cell proliferation.,2021,10.1016/j.jgr.2021.08.006,https://pubmed.ncbi.nlm.nih.gov/34764730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,37947097,Proteomics to Identify New Blood Biomarkers for Diagnosing Patients With Acute Stroke.,2023,10.1161/jaha.123.030021,https://pubmed.ncbi.nlm.nih.gov/37947097/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,35661455,Deregulation of ceRNA Networks in Frontal Cortex and Choroid Plexus of Brain during SARS-CoV-2 Infection Aggravates Neurological Manifestations: An Insight from Bulk and Single-Cell Transcriptomic Analyses.,2022,10.1002/adbi.202101310,https://pubmed.ncbi.nlm.nih.gov/35661455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,33160411,LncRNA STXBP5-AS1 suppresses stem cell-like properties of pancreatic cancer by epigenetically inhibiting neighboring androglobin gene expression.,2020,10.1186/s13148-020-00961-y,https://pubmed.ncbi.nlm.nih.gov/33160411/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,38317187,Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans.,2024,10.1186/s13073-023-01273-5,https://pubmed.ncbi.nlm.nih.gov/38317187/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,37182169,Identification of lncRNAs involved in response to ionizing radiation in fibroblasts of long-term survivors of childhood cancer and cancer-free controls.,2023,10.3389/fonc.2023.1158176,https://pubmed.ncbi.nlm.nih.gov/37182169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,37550093,Associations of multiple genetic variations with plasma levels of Von Willebrand Factor and clinical phenotype in Iranian patients with Von Willebrand disease type 1.,2023,10.1016/j.transci.2023.103766,https://pubmed.ncbi.nlm.nih.gov/37550093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,38584223,Genome-wide 5-hydroxymethylcytosines in circulating cell-free DNA as noninvasive diagnostic markers for gastric cancer.,2024,10.1007/s10120-024-01493-7,https://pubmed.ncbi.nlm.nih.gov/38584223/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,31212131,LncRNA STXBP5-AS1 suppressed cervical cancer progression via targeting miR-96-5p/PTEN axis.,2019,10.1016/j.biopha.2019.109082,https://pubmed.ncbi.nlm.nih.gov/31212131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,37280069,Development of cancer-associated fibroblast-related gene signature for predicting the survival and immunotherapy response in lung adenocarcinoma.,2023,10.18632/aging.204774,https://pubmed.ncbi.nlm.nih.gov/37280069/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,34868337,Identification of the Upregulation of MRPL13 as a Novel Prognostic Marker Associated with Overall Survival Time and Immunotherapy Response in Breast Cancer.,2021,10.1155/2021/1498924,https://pubmed.ncbi.nlm.nih.gov/34868337/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,35075611,Constructing a Novel Signature Based on Immune-Related lncRNA to Improve Prognosis Prediction of Cervical Squamous Cell Carcinoma Patients.,2022,10.1007/s43032-022-00851-z,https://pubmed.ncbi.nlm.nih.gov/35075611/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,31261173,The role of genetics in the pathogenesis and diagnosis of type 1 Von Willebrand disease.,2019,10.1097/moh.0000000000000524,https://pubmed.ncbi.nlm.nih.gov/31261173/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,24578379,Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.,2014,10.1161/atvbaha.113.302088,https://pubmed.ncbi.nlm.nih.gov/24578379/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,32241256,Pseudogene-gene functional networks are prognostic of patient survival in breast cancer.,2020,10.1186/s12920-020-0687-0,https://pubmed.ncbi.nlm.nih.gov/32241256/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,26486471,Genome-wide association studies identify genetic loci for low von Willebrand factor levels.,2016,10.1038/ejhg.2015.222,https://pubmed.ncbi.nlm.nih.gov/26486471/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,31788200,Differential gene expression in chronic wasting disease-positive white-tailed deer (Odocoileus virginianus).,2019,10.1002/ece3.5724,https://pubmed.ncbi.nlm.nih.gov/31788200/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,25045670,Long non-coding RNA deregulation in tongue squamous cell carcinoma.,2014,10.1155/2014/405860,https://pubmed.ncbi.nlm.nih.gov/25045670/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,21163921,Genetic variation associated with plasma von Willebrand factor levels and the risk of incident venous thrombosis.,2011,10.1182/blood-2010-10-315473,https://pubmed.ncbi.nlm.nih.gov/21163921/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
STXBP5,ENSG00000164506,Unsafe,24349514,"MicroRNA-494, upregulated by tumor necrosis factor-α, desensitizes insulin effect in C2C12 muscle cells.",2013,10.1371/journal.pone.0083471,https://pubmed.ncbi.nlm.nih.gov/24349514/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN3,ENSG00000164744,Unsafe,41035184,The mid-SUN-POD1 complex ensures the structural integrity of ER bodies required for herbivore defense in Arabidopsis.,2026,10.1111/nph.70613,https://pubmed.ncbi.nlm.nih.gov/41035184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN3,ENSG00000164744,Unsafe,36825599,SUN4 is a spermatid type II inner nuclear membrane protein that forms heteromeric assemblies with SUN3 and interacts with lamin B3.,2023,10.1242/jcs.260155,https://pubmed.ncbi.nlm.nih.gov/36825599/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN3,ENSG00000164744,Unsafe,39434140,Screening differentially expressed proteins to distinguish thymoma (B1 and B3) from thymic cysts based on tandem mass tag (TMT) technology.,2024,10.1186/s13019-024-03114-x,https://pubmed.ncbi.nlm.nih.gov/39434140/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN3,ENSG00000164744,Unsafe,37176845,In Depth Topological Analysis of Arabidopsis Mid-SUN Proteins and Their Interaction with the Membrane-Bound Transcription Factor MaMYB.,2023,10.3390/plants12091787,https://pubmed.ncbi.nlm.nih.gov/37176845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN3,ENSG00000164744,Unsafe,32156700,The testis-specific LINC component SUN3 is essential for sperm head shaping during mouse spermiogenesis.,2020,10.1074/jbc.ra119.012375,https://pubmed.ncbi.nlm.nih.gov/32156700/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN3,ENSG00000164744,Unsafe,35577772,POD1-SUN-CRT3 chaperone complex guards the ER sorting of LRR receptor kinases in Arabidopsis.,2022,10.1038/s41467-022-30179-w,https://pubmed.ncbi.nlm.nih.gov/35577772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN3,ENSG00000164744,Unsafe,33763102,Evolution and Functional Divergence of SUN Genes in Plants.,2021,10.3389/fpls.2021.646622,https://pubmed.ncbi.nlm.nih.gov/33763102/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN3,ENSG00000164744,Unsafe,26621829,The LINC complex component Sun4 plays a crucial role in sperm head formation and fertility.,2015,10.1242/bio.015768,https://pubmed.ncbi.nlm.nih.gov/26621829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN3,ENSG00000164744,Unsafe,30359793,Molecular evolution of SUN-domain containing proteins in diverse plant species and their expression profiling in response to developmental and perturbation stimuli.,2019,10.1016/j.phytochem.2018.10.007,https://pubmed.ncbi.nlm.nih.gov/30359793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN3,ENSG00000164744,Unsafe,20711465,Mammalian sperm head formation involves different polarization of two novel LINC complexes.,2010,10.1371/journal.pone.0012072,https://pubmed.ncbi.nlm.nih.gov/20711465/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN3,ENSG00000164744,Unsafe,30268407,Protein oligomerization and mobility within the nuclear envelope evaluated by the time-shifted mean-segmented Q factor.,2019,10.1016/j.ymeth.2018.09.008,https://pubmed.ncbi.nlm.nih.gov/30268407/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN3,ENSG00000164744,Unsafe,31022261,Selection signatures in four German warmblood horse breeds: Tracing breeding history in the modern sport horse.,2019,10.1371/journal.pone.0215913,https://pubmed.ncbi.nlm.nih.gov/31022261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN3,ENSG00000164744,Unsafe,24010407,A multilectin affinity approach for comparative glycoprotein profiling of rheumatoid arthritis and spondyloarthropathy.,2013,10.1186/1559-0275-10-11,https://pubmed.ncbi.nlm.nih.gov/24010407/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN3,ENSG00000164744,Unsafe,21711156,"SPAG4L, a novel nuclear envelope protein involved in the meiotic stage of spermatogenesis.",2011,10.1089/dna.2010.1161,https://pubmed.ncbi.nlm.nih.gov/21711156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUN3,ENSG00000164744,Unsafe,19193627,A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.,2009,10.1093/hmg/ddp059,https://pubmed.ncbi.nlm.nih.gov/19193627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,41957462,SUV family histone methyltransferases correlate with nuclear lamina remodeling and clinical outcome in cancer: integrative pan-cancer TCGA analysis and experimental evidence.,2026,10.1038/s41598-026-44020-7,https://pubmed.ncbi.nlm.nih.gov/41957462/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,42463647,SUV39H2-mediated NCOA4 methylation controls ferritinophagy and ferroptosis in triple-negative breast cancer.,2026,10.1038/s41419-026-09008-1,https://pubmed.ncbi.nlm.nih.gov/42463647/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,42853938,Targeting SUV39H2 exon skipping reverses resistance to CDK4/6 inhibitors via transcriptional activation of p21.,2026,10.1126/sciadv.aea2001,https://pubmed.ncbi.nlm.nih.gov/42853938/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,41551146,Role of SUV39H2 in shaping the malignant phenotype of triple-negative breast cancer.,2025,10.3389/fonc.2025.1679640,https://pubmed.ncbi.nlm.nih.gov/41551146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,42707048,Histone H3K9 methyltransferases regulate cortical growth by coordinating heterochromatin formation and neural progenitor dynamics.,2026,10.1242/dev.205584,https://pubmed.ncbi.nlm.nih.gov/42707048/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,41047764,SUV39H2 is a vulnerability in glioblastoma stem cells enhanced by co-targeting SUV39H1.,2025,10.1080/17501911.2025.2568366,https://pubmed.ncbi.nlm.nih.gov/41047764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,41402789,Synthetic lethality from the combination of a histone methyltransferase SUV39H2 inhibitor and a poly (ADP-ribose) polymerase inhibitor for uterine leiomyosarcoma.,2025,10.1186/s12885-025-15267-6,https://pubmed.ncbi.nlm.nih.gov/41402789/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,42140939,H3K9me3 controls epidermis morphogenesis by regulating RNA Pol II dynamics at developmental promoters and enhancers.,2026,10.1038/s41467-026-73308-5,https://pubmed.ncbi.nlm.nih.gov/42140939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,42063540,The basic domain of Suv39h2 buffers mitoxantrone-induced heterochromatin destabilization.,2026,10.1016/j.isci.2026.115626,https://pubmed.ncbi.nlm.nih.gov/42063540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,40849299,CRISPR/Cas9 screening identifies SUV39H2 as a key regulator of oHSV-1 resistance in oral squamous cell carcinoma.,2025,10.1038/s41420-025-02702-7,https://pubmed.ncbi.nlm.nih.gov/40849299/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,42178055,Transcript switching during differentiation of mural and cumulus granulosa cells.,2026,10.1016/j.mce.2026.112831,https://pubmed.ncbi.nlm.nih.gov/42178055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,40650108,Unveiling the Role of Histone Methyltransferases in Psoriasis Pathogenesis: Insights from Transcriptomic Analysis.,2025,10.3390/ijms26136329,https://pubmed.ncbi.nlm.nih.gov/40650108/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,41638075,Inhibition of SUV39H1 and SUV39H2 promotes zygotic genome activation and improves the developmental competence of porcine somatic cell nuclear transfer embryos.,2026,10.1016/j.theriogenology.2026.117853,https://pubmed.ncbi.nlm.nih.gov/41638075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,41078093,TGFBI Inhibits the Pyroptosis of Macrophages to Ameliorate Septic Shock.,2025,10.1111/jcmm.70802,https://pubmed.ncbi.nlm.nih.gov/41078093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,42172506,Epigenetic drug control of Clec4g/LSECtin expression reduces fibrosis burden in cirrhosis.,2026,10.1097/hc9.0000000000000961,https://pubmed.ncbi.nlm.nih.gov/42172506/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,40113969,Multi-omics analysis identifies glioblastoma dependency on H3K9me3 methyltransferase activity.,2025,10.1038/s41698-025-00829-5,https://pubmed.ncbi.nlm.nih.gov/40113969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,39981438,Construction of a circadian rhythm-related gene signature for predicting the prognosis and immune infiltration of breast cancer.,2025,10.3389/fmolb.2025.1540672,https://pubmed.ncbi.nlm.nih.gov/39981438/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,40750792,DCAF13 is essential for mouse uterine function and fertility.,2025,10.1038/s41420-025-02583-w,https://pubmed.ncbi.nlm.nih.gov/40750792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,34559682,SUV39H2/KMT1B Inhibits the cardiomyocyte senescence phenotype by down-regulating BTG2/PC3.,2021,10.18632/aging.203551,https://pubmed.ncbi.nlm.nih.gov/34559682/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,41231099,Autophagy regulates the maternal-to-zygotic transition through MAP1LC3B-mediated maternal mRNA decay.,2026,10.1080/15548627.2025.2589911,https://pubmed.ncbi.nlm.nih.gov/41231099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,42019735,Melatonin corrects HT-2 toxin-induced aberrant histone modifications and DNA hypermethylation in mouse oocytes.,2026,10.1016/j.reprotox.2026.109252,https://pubmed.ncbi.nlm.nih.gov/42019735/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,30719171,The Oncogenic Potential of SUV39H2: A Comprehensive and Perspective View.,2019,10.7150/jca.28254,https://pubmed.ncbi.nlm.nih.gov/30719171/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,39175876,CRISPR-Cas9 screening develops an epigenetic and transcriptional gene signature for risk stratification and target prediction in neuroblastoma.,2024,10.3389/fcell.2024.1433008,https://pubmed.ncbi.nlm.nih.gov/39175876/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,38719473,Suv39h-catalyzed H3K9me3 is critical for euchromatic genome organization and the maintenance of gene transcription.,2024,10.1101/gr.279119.124,https://pubmed.ncbi.nlm.nih.gov/38719473/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,26500027,Targeting Suppressor of Variegation 3-9 Homologue 2 (SUV39H2) in Acute Lymphoblastic Leukemia (ALL).,2015,10.1016/j.tranon.2015.07.003,https://pubmed.ncbi.nlm.nih.gov/26500027/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,36670976,Downregulation of PI3K/AKT/mTOR Pathway in Juglone-Treated Bovine Oocytes.,2023,10.3390/antiox12010114,https://pubmed.ncbi.nlm.nih.gov/36670976/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,35562425,Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance.,2022,10.1038/s41580-022-00483-w,https://pubmed.ncbi.nlm.nih.gov/35562425/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,30159125,Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX.,2018,10.18632/oncotarget.25806,https://pubmed.ncbi.nlm.nih.gov/30159125/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,33850897,A metabolism-related gene signature for predicting the prognosis and therapeutic responses in patients with hepatocellular carcinoma.,2021,10.21037/atm-21-927,https://pubmed.ncbi.nlm.nih.gov/33850897/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,35978026,Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction.,2022,10.1038/s41698-022-00299-z,https://pubmed.ncbi.nlm.nih.gov/35978026/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,28533942,HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses.,2017,10.1080/2162402x.2017.1293214,https://pubmed.ncbi.nlm.nih.gov/28533942/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SUV39H2,ENSG00000152455,Unsafe,35166421,HP1 maintains protein stability of H3K9 methyltransferases and demethylases.,2022,10.15252/embr.202153581,https://pubmed.ncbi.nlm.nih.gov/35166421/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SVOPL,ENSG00000157703,Unsafe,31093489,"Allelic Switching of DLX5, GRB10, and SVOPL during Colorectal Cancer Tumorigenesis.",2019,10.1155/2019/1287671,https://pubmed.ncbi.nlm.nih.gov/31093489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SVOPL,ENSG00000157703,Unsafe,37337823,Genome-wide association and replication studies for handedness in a Korean community-based cohort.,2023,10.1002/brb3.3121,https://pubmed.ncbi.nlm.nih.gov/37337823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SVOPL,ENSG00000157703,Unsafe,36896338,WGCNA-based identification of potential targets and pathways in response to treatment in locally advanced breast cancer patients.,2023,10.1515/med-2023-0651,https://pubmed.ncbi.nlm.nih.gov/36896338/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SVOPL,ENSG00000157703,Unsafe,32241461,Ovary removal modifies liver message RNA profiles in single Comb White Leghorn chickens.,2020,10.1016/j.psj.2019.12.036,https://pubmed.ncbi.nlm.nih.gov/32241461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SVOPL,ENSG00000157703,Unsafe,33823999,Conception by fertility treatment and offspring deoxyribonucleic acid methylation.,2021,10.1016/j.fertnstert.2021.03.011,https://pubmed.ncbi.nlm.nih.gov/33823999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SVOPL,ENSG00000157703,Unsafe,23894296,Loss of the SV2-like protein SVOP produces no apparent deficits in laboratory mice.,2013,10.1371/journal.pone.0068215,https://pubmed.ncbi.nlm.nih.gov/23894296/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SVOPL,ENSG00000157703,Unsafe,27862604,Whole-Genome Sequencing of Cytogenetically Balanced Chromosome Translocations Identifies Potentially Pathological Gene Disruptions and Highlights the Importance of Microhomology in the Mechanism of Formation.,2017,10.1002/humu.23146,https://pubmed.ncbi.nlm.nih.gov/27862604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SVOPL,ENSG00000157703,Unsafe,28878041,"Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression.",2017,10.1098/rsob.170142,https://pubmed.ncbi.nlm.nih.gov/28878041/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SVOPL,ENSG00000157703,Unsafe,29176782,A universal mammalian vaccine cell line substrate.,2017,10.1371/journal.pone.0188333,https://pubmed.ncbi.nlm.nih.gov/29176782/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SVOPL,ENSG00000157703,Unsafe,24247273,Differentially methylated regions in maternal and paternal uniparental disomy for chromosome 7.,2014,10.4161/epi.27160,https://pubmed.ncbi.nlm.nih.gov/24247273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SVOPL,ENSG00000157703,Unsafe,26819647,Genome-wide DNA methylation analysis of pseudohypoparathyroidism patients with GNAS imprinting defects.,2016,10.1186/s13148-016-0175-8,https://pubmed.ncbi.nlm.nih.gov/26819647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SVOPL,ENSG00000157703,Unsafe,17714910,Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family.,2007,10.1016/j.ygeno.2007.03.017,https://pubmed.ncbi.nlm.nih.gov/17714910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,42901904,RNF220 safeguards meiotic synapsis and male fertility by antagonizing SYCE1 ubiquitination.,2026,10.1038/s41419-026-09128-8,https://pubmed.ncbi.nlm.nih.gov/42901904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,41411337,Contrasting effects of DNA demethylation on cancer-germline gene expression in breast cancer and leukemia cells.,2025,10.1371/journal.pone.0339460,https://pubmed.ncbi.nlm.nih.gov/41411337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,42792869,Ubc9 Mediates SUMO2/3 Modification to Regulate Meiosis in Male Mice.,2026,10.3390/biomedicines14092129,https://pubmed.ncbi.nlm.nih.gov/42792869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,42381596,eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes.,2026,10.1002/advs.76264,https://pubmed.ncbi.nlm.nih.gov/42381596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,41467312,SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis.,2026,10.1111/cpr.70158,https://pubmed.ncbi.nlm.nih.gov/41467312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,42059593,"The synaptonemal complex: structure, function, and clinical implications†.",2026,10.1093/biolre/ioag092,https://pubmed.ncbi.nlm.nih.gov/42059593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,39208330,"Differential expression and regulation of ADAD1, DMRTC2, PRSS54, SYCE1, SYCP1, TEX101, TEX48, and TMPRSS12 gene profiles in colon cancer tissues and their in vitro response to epigenetic drugs.",2024,10.1371/journal.pone.0307724,https://pubmed.ncbi.nlm.nih.gov/39208330/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,37957469,"Novel Mutations Reduce Expression of Meiotic Regulators SYCE1 and BOLL in Testis of Azoospermic Men from West Bengal, India.",2024,10.1007/s43032-023-01393-8,https://pubmed.ncbi.nlm.nih.gov/37957469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,41339899,"Genetic and epigenetic insights into non-obstructive azoospermia: mechanisms, biomarkers, and clinical perspectives.",2025,10.1186/s12958-025-01497-7,https://pubmed.ncbi.nlm.nih.gov/41339899/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,35718780,Novel copy number variations within SYCE1 caused meiotic arrest and non-obstructive azoospermia.,2022,10.1186/s12920-022-01288-8,https://pubmed.ncbi.nlm.nih.gov/35718780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,40896145,Genetic determinants of testicular sperm extraction outcomes: insights from a large multicentre study of men with non-obstructive azoospermia.,2025,10.1093/hropen/hoaf049,https://pubmed.ncbi.nlm.nih.gov/40896145/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,35768632,TCFL5 deficiency impairs the pachytene to diplotene transition during spermatogenesis in the mouse.,2022,10.1038/s41598-022-15167-w,https://pubmed.ncbi.nlm.nih.gov/35768632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,35023261,Novel exon mutation in SYCE1 gene is associated with non-obstructive azoospermia.,2022,10.1111/jcmm.17180,https://pubmed.ncbi.nlm.nih.gov/35023261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,35697131,Syce1 and Syce3 regulate testosterone and dihydrotestosterone synthesis via steroidogenic pathways in mouse Sertoli and Leydig cells.,2022,10.1016/j.jsbmb.2022.106135,https://pubmed.ncbi.nlm.nih.gov/35697131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,42221552,Meiotic gene variants contribute to recurrent blastulation failure.,2026,10.1093/hropen/hoag039,https://pubmed.ncbi.nlm.nih.gov/42221552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,40711600,A missense mutation in TCFL5 is associated with male infertility due to oligoasthenoteratozoospermia.,2025,10.1007/s00438-025-02278-y,https://pubmed.ncbi.nlm.nih.gov/40711600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,36041235,Analysis of copy number variation in men with non-obstructive azoospermia.,2022,10.1111/andr.13267,https://pubmed.ncbi.nlm.nih.gov/36041235/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,35848971,Studying the nature of ascending-descending-floating-sinking of Chinese medicines based on gonadotropin-releasing hormone.,2022,10.19852/j.cnki.jtcm.20220516.003,https://pubmed.ncbi.nlm.nih.gov/35848971/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,32917591,Meiotic chromosome synapsis depends on multivalent SYCE1-SIX6OS1 interactions that are disrupted in cases of human infertility.,2020,10.1126/sciadv.abb1660,https://pubmed.ncbi.nlm.nih.gov/32917591/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,35995261,Regulation of DNA methylation during the testicular development of Shaziling pigs.,2022,10.1016/j.ygeno.2022.110450,https://pubmed.ncbi.nlm.nih.gov/35995261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,32782607,A 10-gene signature as a predictor of biochemical recurrence after radical prostatectomy in patients with prostate cancer and a Gleason score ≥7.,2020,10.3892/ol.2020.11830,https://pubmed.ncbi.nlm.nih.gov/32782607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,24970476,"A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets.",2014,10.1158/0008-5472.can-13-3725,https://pubmed.ncbi.nlm.nih.gov/24970476/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,29577858,Expression and Prognostic Relevance of GAGE1 and XAGE1 Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma.,2017,10.2174/1566524018666180322162145,https://pubmed.ncbi.nlm.nih.gov/29577858/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,35413094,Whole-exome sequencing in patients with maturation arrest: a potential additional diagnostic tool for prevention of recurrent negative testicular sperm extraction outcomes.,2022,10.1093/humrep/deac057,https://pubmed.ncbi.nlm.nih.gov/35413094/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1,ENSG00000171772,Unsafe,26243799,Genetics of primary ovarian insufficiency: new developments and opportunities.,2015,10.1093/humupd/dmv036,https://pubmed.ncbi.nlm.nih.gov/26243799/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE1L,ENSG00000205078,Unsafe,42071849,Integrative Mendelian randomization reveals the mediating role of immune cell traits in the causal pathway from gene expression to neonatal bacterial sepsis.,2026,10.1097/md.0000000000048476,https://pubmed.ncbi.nlm.nih.gov/42071849/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE3,ENSG00000217442,Unsafe,42059593,"The synaptonemal complex: structure, function, and clinical implications†.",2026,10.1093/biolre/ioag092,https://pubmed.ncbi.nlm.nih.gov/42059593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE3,ENSG00000217442,Unsafe,39885385,Full-length transcriptome analysis of male and female gonads in Japanese Eel (Anguilla japonica).,2025,10.1186/s12864-025-11279-5,https://pubmed.ncbi.nlm.nih.gov/39885385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE3,ENSG00000217442,Unsafe,38958533,HSF5 Deficiency Causes Male Infertility Involving Spermatogenic Arrest at Meiotic Prophase I in Humans and Mice.,2024,10.1002/advs.202402412,https://pubmed.ncbi.nlm.nih.gov/38958533/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE3,ENSG00000217442,Unsafe,35697131,Syce1 and Syce3 regulate testosterone and dihydrotestosterone synthesis via steroidogenic pathways in mouse Sertoli and Leydig cells.,2022,10.1016/j.jsbmb.2022.106135,https://pubmed.ncbi.nlm.nih.gov/35697131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE3,ENSG00000217442,Unsafe,36635604,Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3.,2023,10.1038/s41594-022-00909-1,https://pubmed.ncbi.nlm.nih.gov/36635604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE3,ENSG00000217442,Unsafe,39566816,Unraveling productivity-enhancing genes in Chinese hamster ovary cells via CRISPR activation screening using recombinase-mediated cassette exchange system.,2025,10.1016/j.ymben.2024.11.009,https://pubmed.ncbi.nlm.nih.gov/39566816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE3,ENSG00000217442,Unsafe,32748829,Deep Transcriptomic Analysis Reveals the Dynamic Developmental Progression during Early Development of Channel Catfish (Ictalurus punctatus).,2020,10.3390/ijms21155535,https://pubmed.ncbi.nlm.nih.gov/32748829/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE3,ENSG00000217442,Unsafe,30949703,SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice.,2019,10.1093/nar/gkz226,https://pubmed.ncbi.nlm.nih.gov/30949703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE3,ENSG00000217442,Unsafe,31479777,Identifying candidate genes associated with sperm morphology abnormalities using weighted single-step GWAS in a Duroc boar population.,2020,10.1016/j.theriogenology.2019.08.031,https://pubmed.ncbi.nlm.nih.gov/31479777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE3,ENSG00000217442,Unsafe,31023827,A molecular model for self-assembly of the synaptonemal complex protein SYCE3.,2019,10.1074/jbc.ra119.008404,https://pubmed.ncbi.nlm.nih.gov/31023827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE3,ENSG00000217442,Unsafe,21637789,"A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility.",2011,10.1371/journal.pgen.1002088,https://pubmed.ncbi.nlm.nih.gov/21637789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE3,ENSG00000217442,Unsafe,28149327,In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain.,2017,10.1186/s13072-017-0111-y,https://pubmed.ncbi.nlm.nih.gov/28149327/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE3,ENSG00000217442,Unsafe,25394919,Structural insight into the central element assembly of the synaptonemal complex.,2014,10.1038/srep07059,https://pubmed.ncbi.nlm.nih.gov/25394919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE3,ENSG00000217442,Unsafe,25831978,Protein SYCP2 is an ancient component of the metazoan synaptonemal complex.,2014,10.1159/000381080,https://pubmed.ncbi.nlm.nih.gov/25831978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE3,ENSG00000217442,Unsafe,30607510,Molecular structure of human synaptonemal complex protein SYCE1.,2019,10.1007/s00412-018-00688-z,https://pubmed.ncbi.nlm.nih.gov/30607510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE3,ENSG00000217442,Unsafe,26661581,Protein markers of synaptic behavior and chromatin remodeling of the neo-XY body in phyllostomid bats.,2016,10.1007/s00412-015-0566-1,https://pubmed.ncbi.nlm.nih.gov/26661581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCE3,ENSG00000217442,Unsafe,20353270,In vitro and in vivo effects of reovirus on HPV16-transformed mice cells.,2010,10.4149/neo_2010_03_207,https://pubmed.ncbi.nlm.nih.gov/20353270/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCN,ENSG00000179751,Unsafe,42434748,"Macrophage inhibitory cytokine 1, syncollin and thrombospondin-2 in pancreatic ductal adenocarcinoma and chronic pancreatitis differentiation.",2026,10.3389/fonc.2026.1866001,https://pubmed.ncbi.nlm.nih.gov/42434748/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCN,ENSG00000179751,Unsafe,37714387,Transcriptome analysis revealed the existence of family-specific regulation of growth traits in grass carp.,2023,10.1016/j.ygeno.2023.110706,https://pubmed.ncbi.nlm.nih.gov/37714387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCN,ENSG00000179751,Unsafe,24007603,Validation of four candidate pancreatic cancer serological biomarkers that improve the performance of CA19.9.,2013,10.1186/1471-2407-13-404,https://pubmed.ncbi.nlm.nih.gov/24007603/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCN,ENSG00000179751,Unsafe,31706267,Integrated transcriptomic analysis reveals hub genes involved in diagnosis and prognosis of pancreatic cancer.,2019,10.1186/s10020-019-0113-2,https://pubmed.ncbi.nlm.nih.gov/31706267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCN,ENSG00000179751,Unsafe,23355975,The SycN/YscB chaperone-binding domain of YopN is required for the calcium-dependent regulation of Yop secretion by Yersinia pestis.,2013,10.3389/fcimb.2013.00001,https://pubmed.ncbi.nlm.nih.gov/23355975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCN,ENSG00000179751,Unsafe,31538697,Bioinformatics Tools and Workflow to Select Blood Biomarkers for Early Cancer Diagnosis: An Application to Pancreatic Cancer.,2019,10.1002/pmic.201800489,https://pubmed.ncbi.nlm.nih.gov/31538697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCN,ENSG00000179751,Unsafe,30718421,Convergent gene losses illuminate metabolic and physiological changes in herbivores and carnivores.,2019,10.1073/pnas.1818504116,https://pubmed.ncbi.nlm.nih.gov/30718421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCN,ENSG00000179751,Unsafe,28630070,Regulation of Type III Secretion of Translocon and Effector Proteins by the EsaB/EsaL/EsaM Complex in Edwardsiella tarda.,2017,10.1128/iai.00322-17,https://pubmed.ncbi.nlm.nih.gov/28630070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCN,ENSG00000179751,Unsafe,24198067,"The Yersinia pestis type III secretion system: expression, assembly and role in the evasion of host defenses.",2013,10.1007/s12026-013-8454-3,https://pubmed.ncbi.nlm.nih.gov/24198067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCN,ENSG00000179751,Unsafe,9882687,"Identification of SycN, YscX, and YscY, three new elements of the Yersinia yop virulon.",1999,10.1128/jb.181.2.675-680.1999,https://pubmed.ncbi.nlm.nih.gov/9882687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCN,ENSG00000179751,Unsafe,11514512,Regulated secretion of YopN by the type III machinery of Yersinia enterocolitica.,2001,10.1128/jb.183.18.5293-5301.2001,https://pubmed.ncbi.nlm.nih.gov/11514512/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCN,ENSG00000179751,Unsafe,10094626,A complex composed of SycN and YscB functions as a specific chaperone for YopN in Yersinia pestis.,1998,10.1046/j.1365-2958.1998.01110.x,https://pubmed.ncbi.nlm.nih.gov/10094626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCN,ENSG00000179751,Unsafe,12535078,"Translocation of YopE and YopN into eukaryotic cells by Yersinia pestis yopN, tyeA, sycN, yscB and lcrG deletion mutants measured using a phosphorylatable peptide tag and phosphospecific antibodies.",2003,10.1046/j.1365-2958.2003.03343.x,https://pubmed.ncbi.nlm.nih.gov/12535078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCN,ENSG00000179751,Unsafe,15502305,"A pivotal role for reductive methylation in the de novo crystallization of a ternary complex composed of Yersinia pestis virulence factors YopN, SycN and YscB.",2004,10.1107/s0907444904023005,https://pubmed.ncbi.nlm.nih.gov/15502305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCN,ENSG00000179751,Unsafe,15262954,Expression of a functional secreted YopN-TyeA hybrid protein in Yersinia pestis is the result of a +1 translational frameshift event.,2004,10.1128/jb.186.15.5160-5166.2004,https://pubmed.ncbi.nlm.nih.gov/15262954/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCN,ENSG00000179751,Unsafe,11844757,YopD and LcrH regulate expression of Yersinia enterocolitica YopQ by a posttranscriptional mechanism and bind to yopQ RNA.,2002,10.1128/jb.184.5.1287-1295.2002,https://pubmed.ncbi.nlm.nih.gov/11844757/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,42493501,SYCP2 recruits HORMAD2 to chromosome axes for unsynapsed chromatin silencing and synapsis surveillance in meiosis.,2026,10.1038/s41467-026-75839-3,https://pubmed.ncbi.nlm.nih.gov/42493501/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,42673516,LncRNA THOR regulates spermatogenesis by interacting with and stabilizing Sycp3 protein in zebrafish†.,2026,10.1093/biolre/ioag185,https://pubmed.ncbi.nlm.nih.gov/42673516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,41182523,Unveiling the expression and mechanistic role of SYCP2 in cervical lesions.,2025,10.1007/s12672-025-03894-1,https://pubmed.ncbi.nlm.nih.gov/41182523/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,41526827,Comprehensive pan-cancer analysis and experimental verification of the roles of SCP2 in colon adenocarcinoma.,2026,10.1186/s12885-025-15519-5,https://pubmed.ncbi.nlm.nih.gov/41526827/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,41594538,Exploration of Novel Markers in Tan Sheep Spermatogenesis.,2026,10.3390/ani16020350,https://pubmed.ncbi.nlm.nih.gov/41594538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,42543885,Ferroptosis-Based Peripheral Immune Dysregulation and Diagnostic Signatures in Parkinson's Disease: An RNA Transcriptomic and Single-Cell Immune Sequencing Analysis.,2026,10.1096/fj.202503867r,https://pubmed.ncbi.nlm.nih.gov/42543885/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,42059593,"The synaptonemal complex: structure, function, and clinical implications†.",2026,10.1093/biolre/ioag092,https://pubmed.ncbi.nlm.nih.gov/42059593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,40918650,ABL1-mediated tyrosine phosphorylation of SYCP2 contributes to transcription-coupled homologous recombination and platinum resistance in ovarian cancer.,2025,10.1093/narcan/zcaf031,https://pubmed.ncbi.nlm.nih.gov/40918650/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,42510638,"Comparative Transcriptomics Reveals Potential Regulatory Mechanisms Underlying Changes in Antioxidant, Anti-Inflammatory, and Other Immune Functions Induced by &lt;i&gt;Bellamya purificata&lt;/i&gt; Polysaccharides in &lt;i&gt;Cherax quadricarinatus&lt;/i&gt;.",2026,10.3390/antiox15070907,https://pubmed.ncbi.nlm.nih.gov/42510638/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,40432880,A novel loss-of-function &lt;i&gt;SYCP2&lt;/i&gt; variant causes asthenoteratozoospermia in infertile males.,2025,10.3389/fgene.2025.1595720,https://pubmed.ncbi.nlm.nih.gov/40432880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,42068772,Genome-wide identification and transcriptomic reprogramming of the hsd17b gene family during endocrine-induced sex reversal in mandarin fish (Siniperca chuatsi).,2026,10.1016/j.cbd.2026.101851,https://pubmed.ncbi.nlm.nih.gov/42068772/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,39202451,Novel Loss-of-Function SYCP2 Variants in Infertile Males Upgrade the Gene-Disease Clinical Validity Classification for SYCP2 and Male Infertility to Strong.,2024,10.3390/genes15081092,https://pubmed.ncbi.nlm.nih.gov/39202451/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,40993092,Targeting the SCP2/HSPB1 Axis: A Novel Mechanism Underlying Ferroptosis Regulation and Hepatocellular Carcinoma Progression.,2026,10.1620/tjem.2025.j116,https://pubmed.ncbi.nlm.nih.gov/40993092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,41894294,The association between lipid metabolism and coronary artery disease: A systematic Mendelian randomization study combined with transcriptome analysis.,2026,10.1097/md.0000000000047880,https://pubmed.ncbi.nlm.nih.gov/41894294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,40788210,[Relationship between sterol carrier protein 2 gene and prostate cancer: Based on single-cell RNA sequencing combined with Mendelian randomization].,2025,,https://pubmed.ncbi.nlm.nih.gov/40788210/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,38383600,Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair.,2024,10.1038/s41467-024-45693-2,https://pubmed.ncbi.nlm.nih.gov/38383600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,41250910,Decoding nuclear-encoded mitochondrial genes in major depressive disorder: A multi-omics perspective.,2025,10.1017/s0033291725102559,https://pubmed.ncbi.nlm.nih.gov/41250910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,41704008,TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy.,2026,10.1002/advs.202521997,https://pubmed.ncbi.nlm.nih.gov/41704008/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,40424650,AFB1 exacerbates testicular and intestinal inflammation by increasing stearoyl ethanolamide and homocysteine levels.,2025,10.1016/j.intimp.2025.114943,https://pubmed.ncbi.nlm.nih.gov/40424650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,39126002,Quantitative Proteomic Analysis Reveals Key Proteins Involved in Testicular Development of Yaks.,2024,10.3390/ijms25158433,https://pubmed.ncbi.nlm.nih.gov/39126002/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,42753730,Zonated cholesterol sensing by SIRT2 drives MASLD-HCC.,2026,10.1016/j.cmet.2026.08.015,https://pubmed.ncbi.nlm.nih.gov/42753730/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,42226445,"Evaluation of Torula Yeast (Candida utilis) Single Cell Proteins as a Partial Replacement for Soybean Meal in Broiler Diets: Effects on Productive Performance, Meat Quality Traits, and Plasma Metabolome.",2026,10.1111/jpn.70082,https://pubmed.ncbi.nlm.nih.gov/42226445/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,39948230,Construction of regulatory T cells specific genes predictive models of prostate cancer patients based on machine learning: a computational analysis and in vitro experiments.,2025,10.1007/s12672-025-01862-3,https://pubmed.ncbi.nlm.nih.gov/39948230/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,39756766,Identification of two novel α-amylase inhibitory activity peptide from Russian sea cucumber body wallprotein hydrolysate.,2025,10.1016/j.ijbiomac.2025.139499,https://pubmed.ncbi.nlm.nih.gov/39756766/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,39765120,Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy.,2025,10.1016/j.ecoenv.2025.117678,https://pubmed.ncbi.nlm.nih.gov/39765120/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,41876721,Dietary quercetagetin enhances antioxidant capacity and modulates intestinal microbiota in dexamethasone-challenged broilers.,2026,10.1038/s41598-026-44135-x,https://pubmed.ncbi.nlm.nih.gov/41876721/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,40533710,"Identification of prostate cancer potential therapeutic targets and virtual drug screening through combined Mendelian randomization study, Bayesian colocalization and molecular docking.",2025,10.1007/s12672-025-02968-4,https://pubmed.ncbi.nlm.nih.gov/40533710/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,40889571,"Epigenetic transgenerational effects of prenatal exposure to 2,2',4,4'-tetrabromodiphenyl ether on sperm function and DNA methylation in rat offspring.",2025,10.1016/j.fct.2025.115716,https://pubmed.ncbi.nlm.nih.gov/40889571/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,42055624,LGALS3BP Links Centrosomes and Mitochondria to Maintain Energetic Fitness and Restrain Compensatory Lipid Catabolic Reprogramming in Hepatocellular Carcinoma.,2026,10.21873/cgp.20581,https://pubmed.ncbi.nlm.nih.gov/42055624/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,36159998,Increased expression of SYCP2 predicts poor prognosis in patients suffering from breast carcinoma.,2022,10.3389/fgene.2022.922401,https://pubmed.ncbi.nlm.nih.gov/36159998/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2,ENSG00000196074,Unsafe,40620061,Mendelian Randomization Analysis of Mitochondria-Related Genes and Screening of Prognostic Genes in Colorectal Cancer.,2025,10.1002/cam4.71012,https://pubmed.ncbi.nlm.nih.gov/40620061/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2L,ENSG00000153157,Unsafe,42059593,"The synaptonemal complex: structure, function, and clinical implications†.",2026,10.1093/biolre/ioag092,https://pubmed.ncbi.nlm.nih.gov/42059593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2L,ENSG00000153157,Unsafe,32303603,Homozygous variants in SYCP2L cause premature ovarian insufficiency.,2021,10.1136/jmedgenet-2019-106789,https://pubmed.ncbi.nlm.nih.gov/32303603/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2L,ENSG00000153157,Unsafe,26362258,Accelerated reproductive aging in females lacking a novel centromere protein SYCP2L.,2015,10.1093/hmg/ddv359,https://pubmed.ncbi.nlm.nih.gov/26362258/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2L,ENSG00000153157,Unsafe,35768515,Comparative transcriptome analysis of Indian domestic duck reveals candidate genes associated with egg production.,2022,10.1038/s41598-022-15099-5,https://pubmed.ncbi.nlm.nih.gov/35768515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2L,ENSG00000153157,Unsafe,30465971,Testicular transcriptome alterations in zebrafish (Danio rerio) exposure to 17β-estradiol.,2019,10.1016/j.chemosphere.2018.11.092,https://pubmed.ncbi.nlm.nih.gov/30465971/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2L,ENSG00000153157,Unsafe,27142338,Prostate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes.,2016,10.1002/cncr.30045,https://pubmed.ncbi.nlm.nih.gov/27142338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2L,ENSG00000153157,Unsafe,11739789,"A novel karyoskeletal protein: characterization of protein NO145, the major component of nucleolar cortical skeleton in Xenopus oocytes.",2001,10.1091/mbc.12.12.3904,https://pubmed.ncbi.nlm.nih.gov/11739789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2L,ENSG00000153157,Unsafe,19448621,Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.,2009,10.1038/ng.385,https://pubmed.ncbi.nlm.nih.gov/19448621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2L,ENSG00000153157,Unsafe,23508249,Replication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study.,2013,10.1093/humrep/det071,https://pubmed.ncbi.nlm.nih.gov/23508249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYCP2L,ENSG00000153157,Unsafe,17374641,Regulatory mechanisms governing the oocyte-specific synthesis of the karyoskeletal protein NO145.,2007,10.1242/jcs.000166,https://pubmed.ncbi.nlm.nih.gov/17374641/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,39994412,Synapsin III promotes neuronal-like transdifferentiation of glioblastoma stem cells by disrupting JAG1-Notch1 interaction.,2025,10.1093/neuonc/noaf056,https://pubmed.ncbi.nlm.nih.gov/39994412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,39832663,Novel peptidomimetic compounds attenuate hypoxic-ischemic brain injury in neonatal rats.,2025,10.1016/j.expneurol.2025.115151,https://pubmed.ncbi.nlm.nih.gov/39832663/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,39511336,Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse model.,2025,10.1038/s41386-024-02020-z,https://pubmed.ncbi.nlm.nih.gov/39511336/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,42486440,Exploring zebrafish models of ADHD: A systematic review of genetic and pharmacological approaches.,2026,10.1016/j.bbr.2026.116393,https://pubmed.ncbi.nlm.nih.gov/42486440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,38743493,"Syn3, a newly developed cyclic peptide and BDNF signaling enhancer, ameliorates retinal ganglion cell degeneration in diabetic retinopathy.",2024,10.1093/procel/pwae028,https://pubmed.ncbi.nlm.nih.gov/38743493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,42809351,Acute effects of whole-body vibration training with additional loading on lower limb muscle synergies during running.,2026,10.37190/abb/220282,https://pubmed.ncbi.nlm.nih.gov/42809351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,38687826,Targeting the postsynaptic scaffolding protein PSD-95 enhances BDNF signaling to mitigate depression-like behaviors in mice.,2024,10.1126/scisignal.adn4556,https://pubmed.ncbi.nlm.nih.gov/38687826/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,42349827,Mutations in the three synapsin genes lead to profound social deficits and cortical dysfunctions.,2026,10.1016/j.pnpbp.2026.111810,https://pubmed.ncbi.nlm.nih.gov/42349827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,40804412,Uterine leiomyoma-like inflammatory myofibroblastic tumour with a rare ALK::SYN3 fusion: a clinicopathologic and molecular analysis.,2025,10.1186/s13000-025-01701-7,https://pubmed.ncbi.nlm.nih.gov/40804412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,41981316,Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting.,2026,10.1038/s41588-026-02564-4,https://pubmed.ncbi.nlm.nih.gov/41981316/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,41561239,Integrating the Data From Microbiome and Metabolome Genome-Wide Association Studies to Uncover Gene-Microbe-Metabolite Interactions in Allergic Diseases.,2025,10.7759/cureus.99600,https://pubmed.ncbi.nlm.nih.gov/41561239/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,38232002,Novel synthetic inducible promoters controlling gene expression during water-deficit stress with green tissue specificity in transgenic poplar.,2024,10.1111/pbi.14289,https://pubmed.ncbi.nlm.nih.gov/38232002/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,40804979,Impact of Heat Stress on Gene Expression in the Hypothalamic-Pituitary-Ovarian Axis of Hu Sheep.,2025,10.3390/ani15152189,https://pubmed.ncbi.nlm.nih.gov/40804979/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,42450718,Weighted Single-Step Genomic Evaluation of Body Structural Traits for Early Selection of Growth Performance in Thai Swamp Buffalo.,2026,10.3390/ani16132012,https://pubmed.ncbi.nlm.nih.gov/42450718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,41639242,Gene variants in the pheromone vomeronasal receptors and QTLs around behavioral and fat metabolism genes associated with altered feed efficiency in cattle.,2026,10.1038/s41598-026-37314-3,https://pubmed.ncbi.nlm.nih.gov/41639242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,41764967,Dynamic regulation of Lower-Limb joint loading during Foot-Abducted landing in wide Lunge: An analysis of muscle synergy and neuromuscular activation patterns.,2026,10.1016/j.jbiomech.2026.113231,https://pubmed.ncbi.nlm.nih.gov/41764967/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,42109582,Predicting progression of Alzheimer's disease using blood-based multi-omics data.,2026,10.1093/bioadv/vbag085,https://pubmed.ncbi.nlm.nih.gov/42109582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,41961139,Melatonin enhances the antitumor and immunomodulatory effects of Bacillus Calmette-Guérin immunotherapy in a murine bladder cancer model.,2026,10.1007/s11033-026-11728-8,https://pubmed.ncbi.nlm.nih.gov/41961139/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,42356813,Comparison of Neuromuscular Control Characteristics in Forehand Stroke Between International- and National-Level Squash Players: An sEMG-Based Analysis of Muscle Synergy and Intermuscular Coherence.,2026,10.3390/s26123840,https://pubmed.ncbi.nlm.nih.gov/42356813/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,40187516,Shared and unique genes and pathways between neuropathic and inflammatory pain assays.,2025,10.1016/j.brainres.2025.149614,https://pubmed.ncbi.nlm.nih.gov/40187516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,37705979,Interferon gene therapy with nadofaragene firadenovec for bladder cancer: from bench to approval.,2023,10.3389/fimmu.2023.1260498,https://pubmed.ncbi.nlm.nih.gov/37705979/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,39131870,The Evolution of Nadofaragene Firadenovec: A Review and the Path Forward.,2024,10.3233/blc-230083,https://pubmed.ncbi.nlm.nih.gov/39131870/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,40970394,"Gene-mediated therapy for BCG-unresponsive nonmuscle-invasive bladder cancer: mechanisms, clinical evidence, and practical implementation.",2025,10.1097/mou.0000000000001345,https://pubmed.ncbi.nlm.nih.gov/40970394/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,39816909,Evaluation of Probiotic Effects on the Growth Performance and Microbiome of Nile Tilapia (Oreochromis niloticus) in a High-Density Biofloc System.,2025,10.1155/anu/5868806,https://pubmed.ncbi.nlm.nih.gov/39816909/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,39380384,Enhancement of the flavor and functional characteristics of cod protein isolate using an enzyme-microbe system.,2024,10.1039/d4fo02272f,https://pubmed.ncbi.nlm.nih.gov/39380384/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,36051251,Pharmacologic Therapies for Non-Muscle Invasive Bladder Cancer: Current and Future Treatments.,2022,10.33696/pharmacol.4.030,https://pubmed.ncbi.nlm.nih.gov/36051251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,41600467,Effects of NMES Combined with Resistance Training Using Underwater Surface EMG Sensors on Neuromuscular Activation of Breaststroke Technique in Breaststroke Athletes: Analysis of Non-Negative Matrix Muscle Synergy.,2026,10.3390/s26020671,https://pubmed.ncbi.nlm.nih.gov/41600467/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,34413083,Syn3 Gene Knockout Negatively Impacts Aspects of Reversal Learning Performance.,2021,10.1523/eneuro.0251-21.2021,https://pubmed.ncbi.nlm.nih.gov/34413083/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,40564278,Genome-Wide Association Analysis of Flavor Precursor Traits in Chengkou Mountain Chicken.,2025,10.3390/ani15121726,https://pubmed.ncbi.nlm.nih.gov/40564278/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,37610508,Impact of synbiotics on growth performance and gut health in Murrah buffalo calves.,2024,10.1007/s11259-023-10194-y,https://pubmed.ncbi.nlm.nih.gov/37610508/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,39559365,Single-cell RNA sequencing analysis identifies acute changes in the tumor microenvironment induced by interferon α gene therapy in a murine bladder cancer model.,2024,10.3389/fimmu.2024.1387229,https://pubmed.ncbi.nlm.nih.gov/39559365/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,35847448,Lentiviral interferon: A novel method for gene therapy in bladder cancer.,2022,10.1016/j.omto.2022.06.005,https://pubmed.ncbi.nlm.nih.gov/35847448/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,36569910,Interaction between glycolysis‒cholesterol synthesis axis and tumor microenvironment reveal that gamma-glutamyl hydrolase suppresses glycolysis in colon cancer.,2022,10.3389/fimmu.2022.979521,https://pubmed.ncbi.nlm.nih.gov/36569910/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,32304379,Bladder-preserving strategies for Bacillus Calmette-Guérin unresponsive non-muscle invasive bladder cancer; where are we and what will be expected?,2020,10.1097/mou.0000000000000792,https://pubmed.ncbi.nlm.nih.gov/32304379/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYN3,ENSG00000185666,Unsafe,28834453,"Intravesical rAd-IFNα/Syn3 for Patients With High-Grade, Bacillus Calmette-Guerin-Refractory or Relapsed Non-Muscle-Invasive Bladder Cancer: A Phase II Randomized Study.",2017,10.1200/jco.2017.72.3064,https://pubmed.ncbi.nlm.nih.gov/28834453/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNGR4,ENSG00000105467,Unsafe,42217082,Pan-cancer multi-omics analysis identifies SYNGR4 as a novel clinical prognostic biomarker and therapeutic target in lung adenocarcinoma.,2026,10.1007/s12672-026-05319-z,https://pubmed.ncbi.nlm.nih.gov/42217082/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNGR4,ENSG00000105467,Unsafe,39902127,Unveiling the role of SYNGR4 in breast cancer development: a novel target for immunotherapy.,2024,10.3389/fonc.2024.1490073,https://pubmed.ncbi.nlm.nih.gov/39902127/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNGR4,ENSG00000105467,Unsafe,39976036,Machine Learning for Chromatin Regulators in Coronary Artery Disease Diagnosis.,2025,10.2174/011871529x352182250207062210,https://pubmed.ncbi.nlm.nih.gov/39976036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNGR4,ENSG00000105467,Unsafe,32686835,Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models.,2020,10.1093/hmg/ddaa140,https://pubmed.ncbi.nlm.nih.gov/32686835/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNGR4,ENSG00000105467,Unsafe,34269186,SYNGR4 and PLEKHB1 deregulation in motor neurons of amyotrophic lateral sclerosis models: potential contributions to pathobiology.,2022,10.4103/1673-5374.317960,https://pubmed.ncbi.nlm.nih.gov/34269186/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,41330442,Roles in physiology and disease of the inositol phosphatase synaptojanin 1.,2026,10.1016/j.bbalip.2025.159708,https://pubmed.ncbi.nlm.nih.gov/41330442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,42517031,Case Report: Deep brain stimulation in SYNJ1-related early-onset parkinsonism.,2026,10.3389/fmed.2026.1895449,https://pubmed.ncbi.nlm.nih.gov/42517031/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,42853660,Dystrophic changes of nigrostriatal axons harboring a &lt;i&gt;SYNJ1&lt;/i&gt; Parkinson's mutation suggest catastrophic failure of endocytic mechanisms.,2026,10.1073/pnas.2622215123,https://pubmed.ncbi.nlm.nih.gov/42853660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,41991085,"DYRK1A and Parkinson's disease, facts and hypotheses.",2026,10.1016/j.nbd.2026.107379,https://pubmed.ncbi.nlm.nih.gov/41991085/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,41927572,Author Correction: Parkinsonism mutations in DNAJC6 cause lipid defects and neurodegeneration that are rescued by Synj1.,2026,10.1038/s41531-026-01327-6,https://pubmed.ncbi.nlm.nih.gov/41927572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,41195642,Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies.,2026,10.1002/acn3.70238,https://pubmed.ncbi.nlm.nih.gov/41195642/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,40488273,Endophilin A1 and synaptojanin 1-dependent endocytosis of synaptic vesicles in nociceptive spinal circuits maintains postoperative and cancer pain.,2025,10.1097/j.pain.0000000000003657,https://pubmed.ncbi.nlm.nih.gov/40488273/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,42310027,iSCORE-PD: an isogenic stem cell collection to research Parkinson's disease.,2026,10.1038/s41467-026-74355-8,https://pubmed.ncbi.nlm.nih.gov/42310027/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,42614171,"Female chronic social defeat stress (&lt;i&gt;fem&lt;/i&gt;CSDS) maps synaptic, bioenergetic and metabolic proteome remodeling in the nucleus accumbens (NAc).",2026,10.3389/fsysb.2026.1904427,https://pubmed.ncbi.nlm.nih.gov/42614171/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,41992374,Integrative Phosphoproteomic Profiling Reveals Stage-Specific Signalling and Metabolism in Equine Melanocytic Neoplasm.,2026,10.1111/vco.70070,https://pubmed.ncbi.nlm.nih.gov/41992374/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,40835006,Proteomic Characterization of the Alzheimer's Disease Risk Factor BIN1 Interactome.,2025,10.1016/j.mcpro.2025.101055,https://pubmed.ncbi.nlm.nih.gov/40835006/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,41502721,Unveiling Dragon's Blood Radiation Mitigation Mechanism: Identifying Key Targets and Bioactive Compounds with Multiomics Using Integrated AI-Driven Models.,2025,10.1021/acsomega.5c10620,https://pubmed.ncbi.nlm.nih.gov/41502721/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,42737551,Rare Variants May Influence Disease Risk and Clinical Features in Sporadic Late-Onset Chinese Parkinson's Disease Patients.,2026,10.3390/ijms27177653,https://pubmed.ncbi.nlm.nih.gov/42737551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,39050701,Haploinsufficiency of the Parkinson's disease gene synaptojanin1 is associated with abnormal responses to psychomotor stimulants and mesolimbic dopamine signaling.,2024,10.3389/fnbeh.2024.1359225,https://pubmed.ncbi.nlm.nih.gov/39050701/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,39455605,Are rare heterozygous SYNJ1 variants associated with Parkinson's disease?,2024,10.1038/s41531-024-00809-9,https://pubmed.ncbi.nlm.nih.gov/39455605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,42409815,Whole-genome sequencing of 197 cases with Parkinson's disease reveals novel pathogenic variants in the Indian population.,2026,10.1038/s41531-026-01462-0,https://pubmed.ncbi.nlm.nih.gov/42409815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,39273702,Identification of SYNJ1 in a Complex Case of Juvenile Parkinsonism Using a Multiomics Approach.,2024,10.3390/ijms25179754,https://pubmed.ncbi.nlm.nih.gov/39273702/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,39117637,"Parkinson's disease gene, Synaptojanin1, dysregulates the surface maintenance of the dopamine transporter.",2024,10.1038/s41531-024-00769-0,https://pubmed.ncbi.nlm.nih.gov/39117637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,37528868,Synaptojanin 1 Modulates Functional Recovery After Incomplete Spinal Cord Injury in Male Apolipoprotein E Epsilon 4 Mice.,2023,10.1089/neur.2023.0023,https://pubmed.ncbi.nlm.nih.gov/37528868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,38836947,Co-occurrence of PRKN and SYNJ1 variants in Early-Onset Parkinson's disease.,2024,10.1007/s11011-024-01362-3,https://pubmed.ncbi.nlm.nih.gov/38836947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,40939428,Identification of bovine genotypes conferring diminished susceptibility to salmonellosis and colonization by Salmonella and E. coli O157:H7.,2025,10.1016/j.vetmic.2025.110725,https://pubmed.ncbi.nlm.nih.gov/40939428/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,39991576,"Identification of a Lactate Accumulation Model to Explain the Heterogeneity in Prognosis, Immune Landscape, and Tumor Environment for HNSCC patients.",2025,10.7150/jca.99560,https://pubmed.ncbi.nlm.nih.gov/39991576/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,40153687,Comprehensive Molecular and Genomic Analysis of NCI-MATCH Subprotocol Y: Capivasertib in Patients With an &lt;i&gt;AKT1 E17K&lt;/i&gt;-Mutated Tumor.,2025,10.1200/po-24-00614,https://pubmed.ncbi.nlm.nih.gov/40153687/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,42456684,Parkinson's disease genetics across diverse ancestries: an observational genetic study of causal and risk variants with translational implications.,2026,10.1016/s1474-4422(26)00198-5,https://pubmed.ncbi.nlm.nih.gov/42456684/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,38152048,Network pharmacology and molecular docking of endogenous active metabolites in diabetic kidney disease.,2023,10.1080/0886022x.2023.2290927,https://pubmed.ncbi.nlm.nih.gov/38152048/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,39201619,Role of Lipids in the Pathogenesis of Parkinson's Disease.,2024,10.3390/ijms25168935,https://pubmed.ncbi.nlm.nih.gov/39201619/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,39427050,Exploration of the shared gene signatures and molecular mechanisms between Alzheimer's disease and intracranial aneurysm.,2024,10.1038/s41598-024-75694-6,https://pubmed.ncbi.nlm.nih.gov/39427050/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,39838718,Spermidine Recovers the Autophagy Defects Underlying the Pathophysiology of Cell Trafficking Disorders.,2025,10.1002/jimd.12841,https://pubmed.ncbi.nlm.nih.gov/39838718/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,36464875,Triplication of &lt;i&gt;Synaptojanin 1&lt;/i&gt; in Alzheimer's Disease Pathology in Down Syndrome.,2022,10.2174/1567205020666221202102832,https://pubmed.ncbi.nlm.nih.gov/36464875/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,40829774,Clinical Profile and Genetic Composition of Patients With Juvenile Parkinsonism From a Single Tertiary Care Center in India.,2026,10.14802/jmd.25132,https://pubmed.ncbi.nlm.nih.gov/40829774/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYNJ1,ENSG00000159082,Unsafe,37667188,Analysis of differentially expressed genes discovers Latroeggtoxin VI-induced changes and SYNJ1 as a main target in PC12 cells.,2023,10.1186/s12864-023-09634-5,https://pubmed.ncbi.nlm.nih.gov/37667188/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT10,ENSG00000110975,Unsafe,39551620,Behavioural phenotypes of Dicer knockout in the mouse SCN.,2024,10.1111/ejn.16605,https://pubmed.ncbi.nlm.nih.gov/39551620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT10,ENSG00000110975,Unsafe,37386035,Genome-wide case-only analysis of gene-gene interactions with known Parkinson's disease risk variants reveals link between LRRK2 and SYT10.,2023,10.1038/s41531-023-00550-9,https://pubmed.ncbi.nlm.nih.gov/37386035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT10,ENSG00000110975,Unsafe,40559938,Hippocampal Proteomics Reveals the Novel Molecular Profiling of Postnatal Lead (Pb) Exposure on Autism-like Behaviors.,2025,10.3390/toxics13060465,https://pubmed.ncbi.nlm.nih.gov/40559938/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT10,ENSG00000110975,Unsafe,39333573,Identification of potential new T cell activation molecules: a Bioinformatic Approach.,2024,10.1038/s41598-024-73003-9,https://pubmed.ncbi.nlm.nih.gov/39333573/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT10,ENSG00000110975,Unsafe,39442698,Methylome-wide association study of adolescent depressive episode with psychotic symptoms and childhood trauma.,2025,10.1016/j.jad.2024.10.029,https://pubmed.ncbi.nlm.nih.gov/39442698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT10,ENSG00000110975,Unsafe,36507940,"A Time-course Transcriptional Kinetics of Genes in Behavior, Cortisol Synthesis and Neurodevelopment in Zebrafish Larvae Exposed to Imidacloprid and Thiamethoxam.",2022,10.1007/s00128-022-03645-w,https://pubmed.ncbi.nlm.nih.gov/36507940/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT10,ENSG00000110975,Unsafe,34155139,Dissecting and modeling photic and melanopsin effects to predict sleep disturbances induced by irregular light exposure in mice.,2021,10.1073/pnas.2017364118,https://pubmed.ncbi.nlm.nih.gov/34155139/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT10,ENSG00000110975,Unsafe,34195885,Genetic predictors of sick sinus syndrome.,2021,10.1007/s11033-021-06517-4,https://pubmed.ncbi.nlm.nih.gov/34195885/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT10,ENSG00000110975,Unsafe,26936998,Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration.,2016,10.1523/jneurosci.2027-15.2016,https://pubmed.ncbi.nlm.nih.gov/26936998/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT10,ENSG00000110975,Unsafe,30919020,Genetics and the heart rate response to exercise.,2019,10.1007/s00018-019-03079-4,https://pubmed.ncbi.nlm.nih.gov/30919020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT10,ENSG00000110975,Unsafe,21496647,Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10.,2011,10.1016/j.cell.2011.03.034,https://pubmed.ncbi.nlm.nih.gov/21496647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT10,ENSG00000110975,Unsafe,21921292,"Synaptotagmin10-Cre, a driver to disrupt clock genes in the SCN.",2011,10.1177/0748730411415363,https://pubmed.ncbi.nlm.nih.gov/21921292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT10,ENSG00000110975,Unsafe,29484034,A robust internal control for high-precision DNA methylation analyses by droplet digital PCR.,2018,10.1186/s13148-018-0456-5,https://pubmed.ncbi.nlm.nih.gov/29484034/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT10,ENSG00000110975,Unsafe,30988672,Genome-Wide SNP Discovery in Indigenous Cattle Breeds of South Africa.,2019,10.3389/fgene.2019.00273,https://pubmed.ncbi.nlm.nih.gov/30988672/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT10,ENSG00000110975,Unsafe,28626000,"BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells.",2017,10.1083/jcb.201702099,https://pubmed.ncbi.nlm.nih.gov/28626000/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT10,ENSG00000110975,Unsafe,27951453,Screening and functional identification of lncRNAs under β-diketone antibiotic exposure to zebrafish (Danio rerio) using high-throughput sequencing.,2017,10.1016/j.aquatox.2016.12.003,https://pubmed.ncbi.nlm.nih.gov/27951453/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT10,ENSG00000110975,Unsafe,18803478,Age-dependent spatial memory loss can be partially restored by immune activation.,2008,10.1089/rej.2008.0755,https://pubmed.ncbi.nlm.nih.gov/18803478/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT10,ENSG00000110975,Unsafe,14756426,Cloning and characterization of human synaptotagmin 10 gene.,2003,10.1080/10425170310001608407,https://pubmed.ncbi.nlm.nih.gov/14756426/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT14,ENSG00000143469,Unsafe,39966626,Human mood disorder risk gene Synaptotagmin-14 contributes to mania-like behaviors in mice.,2025,10.1038/s41380-025-02933-1,https://pubmed.ncbi.nlm.nih.gov/39966626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT14,ENSG00000143469,Unsafe,41271589,Molecular insights into electroreceptor ribbon synapses from differential gene expression in sturgeon lateral line organs.,2026,10.1111/joa.70061,https://pubmed.ncbi.nlm.nih.gov/41271589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT14,ENSG00000143469,Unsafe,41153404,A Genome-Wide Association Study in Psoriasis Patients Reveals Variants Associated with Response to Treatment with Interleukin-17A Pathway Inhibitors.,2025,10.3390/genes16101187,https://pubmed.ncbi.nlm.nih.gov/41153404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT14,ENSG00000143469,Unsafe,38608796,The potential up-regulation risk of 3' UTR SNP (rs10787760 G &gt; A) for the VAX1 gene is associated with NSCLP in the northwest Chinese population.,2024,10.1016/j.gene.2024.148458,https://pubmed.ncbi.nlm.nih.gov/38608796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT14,ENSG00000143469,Unsafe,34229539,Comprehensive analysis on the expression profile and prognostic values of Synaptotagmins (SYTs) family members and their methylation levels in gastric cancer.,2021,10.1080/21655979.2021.1951059,https://pubmed.ncbi.nlm.nih.gov/34229539/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT14,ENSG00000143469,Unsafe,34534285,"Insm1, Neurod1, and Pax6 promote murine pancreatic endocrine cell development through overlapping yet distinct RNA transcription and splicing programs.",2021,10.1093/g3journal/jkab303,https://pubmed.ncbi.nlm.nih.gov/34534285/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT14,ENSG00000143469,Unsafe,39729750,Tumor gene expression is associated with venous thromboembolism in patients with ductal pancreatic adenocarcinoma.,2025,10.1016/j.thromres.2024.109240,https://pubmed.ncbi.nlm.nih.gov/39729750/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT14,ENSG00000143469,Unsafe,29634997,RNAi-mediated SYT14 knockdown inhibits the growth of human glioma cell line U87MG.,2018,10.1016/j.brainresbull.2018.04.002,https://pubmed.ncbi.nlm.nih.gov/29634997/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT14,ENSG00000143469,Unsafe,33108691,Identification of novel susceptibility loci for non-syndromic cleft lip with or without cleft palate.,2020,10.1111/jcmm.15878,https://pubmed.ncbi.nlm.nih.gov/33108691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT14,ENSG00000143469,Unsafe,34947986,"Involvement of Rare Mutations of SCN9A, DPP4, ABCA13, and SYT14 in Schizophrenia and Bipolar Disorder.",2021,10.3390/ijms222413189,https://pubmed.ncbi.nlm.nih.gov/34947986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT14,ENSG00000143469,Unsafe,27351839,Analysis of the Differentiation of Kenyon Cell Subtypes Using Three Mushroom Body-Preferential Genes during Metamorphosis in the Honeybee (Apis mellifera L.).,2016,10.1371/journal.pone.0157841,https://pubmed.ncbi.nlm.nih.gov/27351839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT14,ENSG00000143469,Unsafe,32973469,Neurophysiological and Genetic Findings in Patients With Juvenile Myoclonic Epilepsy.,2020,10.3389/fnint.2020.00045,https://pubmed.ncbi.nlm.nih.gov/32973469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT14,ENSG00000143469,Unsafe,21835308,"Exome sequencing reveals a homozygous SYT14 mutation in adult-onset, autosomal-recessive spinocerebellar ataxia with psychomotor retardation.",2011,10.1016/j.ajhg.2011.07.012,https://pubmed.ncbi.nlm.nih.gov/21835308/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT14,ENSG00000143469,Unsafe,34288924,Gene expression changes in male and female rhesus macaque 60 days after irradiation.,2021,10.1371/journal.pone.0254344,https://pubmed.ncbi.nlm.nih.gov/34288924/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
SYT14,ENSG00000143469,Unsafe,17304550,Disruption of a synaptotagmin (SYT14) associated with neurodevelopmental abnormalities.,2007,10.1002/ajmg.a.31618,https://pubmed.ncbi.nlm.nih.gov/17304550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,41592600,FOXM1 influences DNA methylation to augment TACC3 alternative splicing directed by KAT2A in hepatocellular carcinoma.,2026,10.3350/cmh.2025.1370,https://pubmed.ncbi.nlm.nih.gov/41592600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,42499031,"TACC3, correlated with immune cell infiltrates, is a novel prognostic biomarker in BRCA.",2026,10.1097/md.0000000000049943,https://pubmed.ncbi.nlm.nih.gov/42499031/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,42181836,A Multi-omics Investigation Identifies TACC3 as a Driver of Immunosuppression in Intrahepatic Cholangiocarcinoma via Activation of the STAT3-PD-L1 Axis.,2026,10.14218/jcth.2025.00616,https://pubmed.ncbi.nlm.nih.gov/42181836/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,42049022,Mechanistic design of cell-penetrating disruptors for phospho-dependent TACC3-CHC interaction.,2026,10.1016/j.str.2026.04.001,https://pubmed.ncbi.nlm.nih.gov/42049022/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,42381324,Cross-Tissue Transcriptome-Wide Association Study Prioritizes Candidate Genes and Compound-Associated Signatures for Osteoarthritis.,2026,10.2174/0113816128481898260605051256,https://pubmed.ncbi.nlm.nih.gov/42381324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,41892193,From a Polymorphous Low-Grade Neuroepithelial Tumor to a Glioblastoma in an Adult Patient with FGFR3-TACC3 Fusion: A Case Report and Literature Review of the Molecular Profile.,2026,10.3390/curroncol33030165,https://pubmed.ncbi.nlm.nih.gov/41892193/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,40866361,Transforming acidic coiled-coil-containing protein 3-mediated lipid metabolism reprogramming impairs CD8&lt;sup&gt;+&lt;/sup&gt; T-cell cytotoxicity in hepatocellular carcinoma.,2025,10.1038/s41392-025-02367-9,https://pubmed.ncbi.nlm.nih.gov/40866361/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,42377805,FGFR3::TACC3 Fusion and NOTCH1 Loss-of-Function in a Case of HPV-Associated Sinonasal Squamous Cell Carcinoma: Diagnostic Challenge and Implications for Targeted Therapy.,2026,10.1007/s12105-026-01947-7,https://pubmed.ncbi.nlm.nih.gov/42377805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,42058998,FGFR alterations and potential role of FGFR inhibitors in pediatric brain tumors.,2026,10.1093/noajnl/vdaf113,https://pubmed.ncbi.nlm.nih.gov/42058998/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,41185057,Diffusely metastatic glioblastoma with FGFR3::TACC3 fusion: cell-free DNA fragmentation analyses and molecular characterization of matched primary and metastatic tumor sites.,2025,10.1186/s40478-025-02142-5,https://pubmed.ncbi.nlm.nih.gov/41185057/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,40358390,Human Papillomavirus Integration Induces Oncogenic Host Gene Fusions in Oropharyngeal Cancers.,2025,10.1158/2159-8290.cd-24-1535,https://pubmed.ncbi.nlm.nih.gov/40358390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,40672757,Correction: FGFR3-TACC3 fusion gene promotes glioblastoma malignant progression through the activation of STAT3 signaling pathway.,2025,10.3389/fonc.2025.1637363,https://pubmed.ncbi.nlm.nih.gov/40672757/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,41907614,&lt;i&gt;FGFR3-TACC3&lt;/i&gt; fusion as a potential primary resistance mechanism to EGFR-TKI in lung adenocarcinoma harboring co-driven mutations: a case report.,2026,10.3389/fonc.2026.1780493,https://pubmed.ncbi.nlm.nih.gov/41907614/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,40373614,TACC3 facilitates chondrocyte differentiation by attenuating abnormally activated FGFR3 signaling in achondroplasia - An in vitro study.,2025,10.1016/j.tice.2025.102940,https://pubmed.ncbi.nlm.nih.gov/40373614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,42586248,Non-small cell lung carcinomas with diffuse co-expression of TTF-1 and p40: Clinicopathologic and molecular characterization of a rare phenotype.,2026,10.1016/j.humpath.2026.106219,https://pubmed.ncbi.nlm.nih.gov/42586248/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,39408967,Localization and Tumor Growth Inhibition of I-131-Labeled Monoclonal Antibody ERIC1 in a Subcutaneous Xenograft Model of Small Cell Lung Cancer in SCID Mice.,2024,10.3390/ijms251910638,https://pubmed.ncbi.nlm.nih.gov/39408967/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,39603208,Development and validation of a radiomic prediction model for TACC3 expression and prognosis in non-small cell lung cancer using contrast-enhanced CT imaging.,2025,10.1016/j.tranon.2024.102211,https://pubmed.ncbi.nlm.nih.gov/39603208/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,40417325,Diffuse glioma with &lt;i&gt;FGFR3&lt;/i&gt;::&lt;i&gt;TACC3&lt;/i&gt; gene fusion and prominent calcification: A case report.,2025,10.1016/j.radcr.2025.04.034,https://pubmed.ncbi.nlm.nih.gov/40417325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,39409066,Tumoricidal Activity and Side Effects of Radiolabeled Anti-NCAM [131I]-Iodine-ERIC1 in Neuroblastoma-Bearing Mice.,2024,10.3390/ijms251910737,https://pubmed.ncbi.nlm.nih.gov/39409066/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,41165398,Diffuse glioma with FGFR3-TACC3 fusion in adults is not a homogenous clinicopathological and molecular entity.,2025,10.1002/2056-4538.70057,https://pubmed.ncbi.nlm.nih.gov/41165398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,41100064,Pemigatinib for previously treated metastatic or unresectable central nervous system tumors with fibroblast growth factor receptor mutations or rearrangements: FIGHT-207 results.,2025,10.1093/oncolo/oyaf272,https://pubmed.ncbi.nlm.nih.gov/41100064/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,39510064,Prognostic and Immunotherapeutic Role of TACC3 in Pancancer and Its Impact on Proliferation and Docetaxel Resistance in Lung Adenocarcinoma.,2025,10.1159/000542450,https://pubmed.ncbi.nlm.nih.gov/39510064/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,41567627,Fibroblast growth factor receptor inhibitors in glioma: a narrative review of recent advances.,2025,10.3389/fphar.2025.1714696,https://pubmed.ncbi.nlm.nih.gov/41567627/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,40412795,Radiotherapy-induced TACC3 confers resistance of HCC to radiotherapy and enhances IL4-dependent immunosuppression to exacerbate hepatocarcinogenesis.,2025,10.1016/j.canlet.2025.217819,https://pubmed.ncbi.nlm.nih.gov/40412795/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,40603902,FGFR inhibitors promote the autophagic degradation of IFN-γ-induced PD-L1 and alleviate the PD-L1-mediated transcriptional suppression of FGFR3-TACC3 in non-muscle-invasive bladder cancer.,2025,10.1038/s41419-025-07821-8,https://pubmed.ncbi.nlm.nih.gov/40603902/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,39306889,Pluripotent stem cell-derived CTLs targeting FGFR3-TACC3 fusion gene in osteosarcoma.,2024,10.1016/j.intimp.2024.112862,https://pubmed.ncbi.nlm.nih.gov/39306889/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,41936598,Identification of natural FGFR3 inhibitor for glioma using integrated computational and microRNA regulatory analysis.,2026,10.1038/s41598-026-45845-y,https://pubmed.ncbi.nlm.nih.gov/41936598/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,41207822,Virus-mediated gene fusion: igniting and sustaining oncogenesis.,2025,10.1016/j.trecan.2025.10.008,https://pubmed.ncbi.nlm.nih.gov/41207822/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,39889548,Isoxazole-pyrimidine derivatives as TACC3 inhibitors: A novel modality to targeted cancer therapy.,2025,10.1016/j.bioorg.2025.108204,https://pubmed.ncbi.nlm.nih.gov/39889548/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TACC3,ENSG00000013810,Unsafe,41986521,Clinicopathologic features of KRAS G12C-mutated non-small cell lung carcinomas:insights from 279 retrospective cases.,2026,10.1007/s00428-026-04526-x,https://pubmed.ncbi.nlm.nih.gov/41986521/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TADA2A,ENSG00000276234,Unsafe,40772539,PCR-RFLP assays to detect recessive lethal alleles in Landrace and Duroc pigs in Vietnam.,2025,10.1177/10406387251318022,https://pubmed.ncbi.nlm.nih.gov/40772539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TADA2A,ENSG00000276234,Unsafe,40608154,CircTADA2A inhibits cell proliferation and promotes ferroptosis by sponging miR-638 in acute myeloid leukemia.,2025,10.1007/s13577-025-01251-6,https://pubmed.ncbi.nlm.nih.gov/40608154/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TADA2A,ENSG00000276234,Unsafe,39097891,Circ_0006220 (circ-TADA2A) accelerates prostate cancer cell malignant behaviors through miR-520f-3p/CDCA7 axis.,2024,10.14715/cmb/2024.70.7.12,https://pubmed.ncbi.nlm.nih.gov/39097891/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TADA2A,ENSG00000276234,Unsafe,38347496,Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis.,2024,10.1186/s12711-024-00882-x,https://pubmed.ncbi.nlm.nih.gov/38347496/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TADA2A,ENSG00000276234,Unsafe,38007639,Integrative analysis of histone acetyltransferase KAT2A in human cancer.,2023,10.3233/cbm-220464,https://pubmed.ncbi.nlm.nih.gov/38007639/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TADA2A,ENSG00000276234,Unsafe,34065515,α-Synuclein A53T Binds to Transcriptional Adapter 2-Alpha and Blocks Histone H3 Acetylation.,2021,10.3390/ijms22105392,https://pubmed.ncbi.nlm.nih.gov/34065515/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TADA2A,ENSG00000276234,Unsafe,34588429,Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis.,2021,10.1038/s41419-021-04193-7,https://pubmed.ncbi.nlm.nih.gov/34588429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TADA2A,ENSG00000276234,Unsafe,34296306,Circular RNA TADA2A promotes proliferation and migration via modulating of miR‑638/KIAA0101 signal in non‑small cell lung cancer.,2021,10.3892/or.2021.8152,https://pubmed.ncbi.nlm.nih.gov/34296306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TADA2A,ENSG00000276234,Unsafe,32694556,CircRNA TADA2A relieves idiopathic pulmonary fibrosis by inhibiting proliferation and activation of fibroblasts.,2020,10.1038/s41419-020-02747-9,https://pubmed.ncbi.nlm.nih.gov/32694556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TADA2A,ENSG00000276234,Unsafe,39013295,Further screening of SNP loci of eggshell translucency related genes and evaluation of genetic effects.,2024,10.1016/j.psj.2024.103963,https://pubmed.ncbi.nlm.nih.gov/39013295/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TADA2A,ENSG00000276234,Unsafe,32799891,CircTADA2A suppresses the progression of colorectal cancer via miR-374a-3p/KLF14 axis.,2020,10.1186/s13046-020-01642-7,https://pubmed.ncbi.nlm.nih.gov/32799891/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TADA2A,ENSG00000276234,Unsafe,38216274,"Prenatal diagnosis and perinatal findings of 17q12 microdeletion encompassing HNF1B in a fetus with bilateral hyperechogenic kidneys on fetal ultrasound and mild renal abnormality after birth, and a review of the literature of prenatal diagnosis of 17q12 microdeletion.",2024,10.1016/j.tjog.2023.10.005,https://pubmed.ncbi.nlm.nih.gov/38216274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TADA2A,ENSG00000276234,Unsafe,29181107,Investigation of fusion gene expression in HCT116 cells.,2017,10.3892/ol.2017.7055,https://pubmed.ncbi.nlm.nih.gov/29181107/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TADA2A,ENSG00000276234,Unsafe,33293831,TRPS1 and YAP1 Regulate Cell Proliferation and Drug Resistance of Osteosarcoma via Competitively Binding to the Target of circTADA2A - miR-129-5p.,2020,10.2147/ott.s276953,https://pubmed.ncbi.nlm.nih.gov/33293831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TADA2A,ENSG00000276234,Unsafe,29514634,Multi-tissue transcriptomic study reveals the main role of liver in the chicken adaptive response to a switch in dietary energy source through the transcriptional regulation of lipogenesis.,2018,10.1186/s12864-018-4520-5,https://pubmed.ncbi.nlm.nih.gov/29514634/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TADA2A,ENSG00000276234,Unsafe,29049012,Transcriptome Profiling Uncovers Potential Common Mechanisms in Fetal Trisomies 18 and 21.,2017,10.1089/omi.2017.0123,https://pubmed.ncbi.nlm.nih.gov/29049012/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TADA2A,ENSG00000276234,Unsafe,30875370,Loss of function mutations in essential genes cause embryonic lethality in pigs.,2019,10.1371/journal.pgen.1008055,https://pubmed.ncbi.nlm.nih.gov/30875370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TADA2A,ENSG00000276234,Unsafe,22178801,Prenatally diagnosed 17q12 microdeletion syndrome with a novel association with congenital diaphragmatic hernia.,2012,10.1159/000332968,https://pubmed.ncbi.nlm.nih.gov/22178801/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1A,ENSG00000143498,Unsafe,41588282,LncRNA TAF1A-AS1 regulates the progression in hepatocellular carcinoma by targeting miR-664b-3p/USP22 axis.,2026,10.1007/s12672-026-04454-x,https://pubmed.ncbi.nlm.nih.gov/41588282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1A,ENSG00000143498,Unsafe,40902972,Nucleolar protein DCAF13 promotes non-small cell lung cancer cell proliferation via facilitating rDNA transcription and ribosome biogenesis.,2025,10.1016/j.jbc.2025.110656,https://pubmed.ncbi.nlm.nih.gov/40902972/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1A,ENSG00000143498,Unsafe,39209150,Biallelic potential disease-causing missense variants in TAF1A in two siblings with infantile restrictive cardiomyopathy.,2024,10.1016/j.ejmg.2024.104968,https://pubmed.ncbi.nlm.nih.gov/39209150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1A,ENSG00000143498,Unsafe,39993547,"Key genes linking gut microbiota, immune cells, and osteoporosis: A multi-omics approach.",2025,10.1016/j.micpath.2025.107412,https://pubmed.ncbi.nlm.nih.gov/39993547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1A,ENSG00000143498,Unsafe,37501913,"Juvenile-onset multifocal atrial arrhythmias, atrial standstill and compound heterozygosity of genetic variants in TAF1A: sentinel event for evolving dilated cardiomyopathy-a case report.",2023,10.1093/ehjcr/ytad255,https://pubmed.ncbi.nlm.nih.gov/37501913/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1A,ENSG00000143498,Unsafe,39175876,CRISPR-Cas9 screening develops an epigenetic and transcriptional gene signature for risk stratification and target prediction in neuroblastoma.,2024,10.3389/fcell.2024.1433008,https://pubmed.ncbi.nlm.nih.gov/39175876/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1A,ENSG00000143498,Unsafe,33311601,TAF1A and ZBTB41 serve as novel key genes in cervical cancer identified by integrated approaches.,2021,10.1038/s41417-020-00278-1,https://pubmed.ncbi.nlm.nih.gov/33311601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1A,ENSG00000143498,Unsafe,39369230,LINC01116-dependent upregulation of RNA polymerase I transcription drives oncogenic phenotypes in lung adenocarcinoma.,2024,10.1186/s12967-024-05715-5,https://pubmed.ncbi.nlm.nih.gov/39369230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1A,ENSG00000143498,Unsafe,35925837,TFIIB-related factor 1 is a nucleolar protein that promotes RNA polymerase I-directed transcription and tumour cell growth.,2023,10.1093/hmg/ddac152,https://pubmed.ncbi.nlm.nih.gov/35925837/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1A,ENSG00000143498,Unsafe,28777933,Heterozygous De Novo UBTF Gain-of-Function Variant Is Associated with Neurodegeneration in Childhood.,2017,10.1016/j.ajhg.2017.07.002,https://pubmed.ncbi.nlm.nih.gov/28777933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1A,ENSG00000143498,Unsafe,28472305,Recessive TAF1A mutations reveal ribosomopathy in siblings with end-stage pediatric dilated cardiomyopathy.,2017,10.1093/hmg/ddx169,https://pubmed.ncbi.nlm.nih.gov/28472305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1A,ENSG00000143498,Unsafe,32522293,A potential prognostic prediction model of colon adenocarcinoma with recurrence based on prognostic lncRNA signatures.,2020,10.1186/s40246-020-00270-8,https://pubmed.ncbi.nlm.nih.gov/32522293/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1A,ENSG00000143498,Unsafe,27878435,Novel phenotypes and loci identified through clinical genomics approaches to pediatric cataract.,2017,10.1007/s00439-016-1747-6,https://pubmed.ncbi.nlm.nih.gov/27878435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1A,ENSG00000143498,Unsafe,29367541,Diagnostic Yield of Whole Exome Sequencing in Pediatric Dilated Cardiomyopathy.,2017,10.3390/jcdd4030011,https://pubmed.ncbi.nlm.nih.gov/29367541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1A,ENSG00000143498,Unsafe,26811294,Detection of genes associated with developmental competence of bovine oocytes.,2016,10.1016/j.anireprosci.2016.01.004,https://pubmed.ncbi.nlm.nih.gov/26811294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1A,ENSG00000143498,Unsafe,17069796,"Global functional analysis of nucleophosmin in Taxol response, cancer, chromatin regulation, and ribosomal DNA transcription.",2007,10.1016/j.yexcr.2006.09.016,https://pubmed.ncbi.nlm.nih.gov/17069796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF1A,ENSG00000143498,Unsafe,17954271,Transcriptional profiling of genes at the human common fragile site FRA1H in tumor-derived cell lines.,2007,10.1016/j.cancergencyto.2007.07.004,https://pubmed.ncbi.nlm.nih.gov/17954271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,41814948,Coordinating meiotic prophase I progression and early oocyte differentiation.,2026,10.1242/dev.205203,https://pubmed.ncbi.nlm.nih.gov/41814948/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,39281470,EEF1B2 regulates the proliferation and apoptosis of human spermatogonial stem cell lines through TAF4B.,2024,10.1016/j.heliyon.2024.e36467,https://pubmed.ncbi.nlm.nih.gov/39281470/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,37900284,Transcription and chromatin regulation by TAF4b during cellular quiescence of developing prospermatogonia.,2023,10.3389/fcell.2023.1270408,https://pubmed.ncbi.nlm.nih.gov/37900284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,39494734,Overexpression of TAF4B Promoted the Proliferation of Undifferentiated Spermatogonia in Cattleyak In Vitro.,2024,10.1111/rda.14738,https://pubmed.ncbi.nlm.nih.gov/39494734/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,38271475,Splicing factor SRSF1 is essential for homing of precursor spermatogonial stem cells in mice.,2024,10.7554/elife.89316,https://pubmed.ncbi.nlm.nih.gov/38271475/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,35043944,TAF4b transcription networks regulating early oocyte differentiation.,2022,10.1242/dev.200074,https://pubmed.ncbi.nlm.nih.gov/35043944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,39430741,Circular RNA TAF4B targeting MFN2 accelerates cell growth in bladder cancer through p27 depression and AKT activation.,2024,10.3389/fimmu.2024.1477196,https://pubmed.ncbi.nlm.nih.gov/39430741/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,31932482,ZFP628 Is a TAF4b-Interacting Transcription Factor Required for Mouse Spermiogenesis.,2020,10.1128/mcb.00228-19,https://pubmed.ncbi.nlm.nih.gov/31932482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,37013480,miR-34a-5p as molecular hub of pathomechanisms in Huntington's disease.,2023,10.1186/s10020-023-00640-7,https://pubmed.ncbi.nlm.nih.gov/37013480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,38136955,Genome-Wide Association Studies and Runs of Homozygosity to Identify Reproduction-Related Genes in Yorkshire Pig Population.,2023,10.3390/genes14122133,https://pubmed.ncbi.nlm.nih.gov/38136955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,40211853,Transcriptomic analysis identifies CXCL12 as a novel candidate gene for litter size in rabbits.,2026,10.5713/ab.24.0640,https://pubmed.ncbi.nlm.nih.gov/40211853/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,32502024,Analysis of TATA-box binding protein associated factor 4b gene mutations in a Chinese population with nonobstructive azoospermia.,2020,10.1097/md.0000000000020561,https://pubmed.ncbi.nlm.nih.gov/32502024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,34556135,Successful transplantation of spermatogonial stem cells into the seminiferous tubules of busulfan-treated mice.,2021,10.1186/s12978-021-01242-4,https://pubmed.ncbi.nlm.nih.gov/34556135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,31914128,Dynamic and regulated TAF gene expression during mouse embryonic germ cell development.,2020,10.1371/journal.pgen.1008515,https://pubmed.ncbi.nlm.nih.gov/31914128/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,32655042,Next-generation sequencing: toward an increase in the diagnostic yield in patients with apparently idiopathic spermatogenic failure.,2021,10.4103/aja.aja_25_20,https://pubmed.ncbi.nlm.nih.gov/32655042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,38126142,Participation of the TBP-associated factors (TAFs) in cell differentiation.,2024,10.1002/jcp.31167,https://pubmed.ncbi.nlm.nih.gov/38126142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,38478424,4D label-free quantitative proteomic analysis identifies CRABP1 as a novel candidate gene for litter size in rabbits†.,2024,10.1093/biolre/ioae038,https://pubmed.ncbi.nlm.nih.gov/38478424/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,35504087,N6-methyladenosine RNA demethylase ALKBH5 is testis-specifically downregulated in hybrid male sterile dzo and is a target gene of bta-miR-200a.,2022,10.1016/j.theriogenology.2022.04.022,https://pubmed.ncbi.nlm.nih.gov/35504087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,39312076,N-acetylcysteine mitigates oxidative damage to the ovary in D-galactose-induced ovarian failure in rabbits.,2024,10.1007/s11033-024-09951-2,https://pubmed.ncbi.nlm.nih.gov/39312076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,34322376,Circular RNA TAF4B Promotes Bladder Cancer Progression by Sponging miR-1298-5p and Regulating TGFA Expression.,2021,10.3389/fonc.2021.643362,https://pubmed.ncbi.nlm.nih.gov/34322376/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,34639162,Transcriptome Analyses Identify Potential Key microRNAs and Their Target Genes Contributing to Ovarian Reserve.,2021,10.3390/ijms221910819,https://pubmed.ncbi.nlm.nih.gov/34639162/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,11856754,Enhanced apoptosis of B and T lymphocytes in TAFII105 dominant-negative transgenic mice is linked to nuclear factor-kappa B.,2002,10.1074/jbc.m200696200,https://pubmed.ncbi.nlm.nih.gov/11856754/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,16088961,Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line.,2005,10.1002/jcb.20577,https://pubmed.ncbi.nlm.nih.gov/16088961/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF4B,ENSG00000141384,Unsafe,8858156,Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130.,1996,10.1016/s0092-8674(00)81330-6,https://pubmed.ncbi.nlm.nih.gov/8858156/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,41730469,Activation of taf7l promotes sensory nerve regeneration by enhancing conditioning effect.,2026,10.1016/j.neulet.2026.138559,https://pubmed.ncbi.nlm.nih.gov/41730469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,38112167,TAF7L regulates early stages of male germ cell development in the rat.,2024,10.1096/fj.202301716rr,https://pubmed.ncbi.nlm.nih.gov/38112167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,36714566,Deleterious variants in TAF7L cause human oligoasthenoteratozoospermia and its impairing histone to protamine exchange inducing reduced &lt;i&gt;in vitro&lt;/i&gt; fertilization.,2022,10.3389/fendo.2022.1099270,https://pubmed.ncbi.nlm.nih.gov/36714566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,35554494,Genetic characterization of a missense mutation in the X-linked TAF7L gene identified in an oligozoospermic man†.,2022,10.1093/biolre/ioac093,https://pubmed.ncbi.nlm.nih.gov/35554494/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,42039311,Selection signatures on the autosomes and the X chromosome in the prolific Belclare sheep breed.,2026,10.1016/j.vas.2026.100659,https://pubmed.ncbi.nlm.nih.gov/42039311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,38643268,Integrative analysis in head and neck cancer reveals distinct role of miRNome and methylome as tumour epigenetic drivers.,2024,10.1038/s41598-024-59312-z,https://pubmed.ncbi.nlm.nih.gov/38643268/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,34319233,Epi-mutations for spermatogenic defects by maternal exposure to di(2-ethylhexyl) phthalate.,2021,10.7554/elife.70322,https://pubmed.ncbi.nlm.nih.gov/34319233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,31065688,Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis.,2020,10.1093/jmcb/mjz035,https://pubmed.ncbi.nlm.nih.gov/31065688/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,34453732,Unraveling the Regulation of Cancer/Testis Antigens in Tumorigenesis Through an Analysis of Normal Germ Cell Development in Rodents.,2021,10.1007/978-3-030-77779-1_4,https://pubmed.ncbi.nlm.nih.gov/34453732/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,40435666,DEHP exposure alters carcinoembryonic antigen family member transcript levels and modulates responses to activin A in the murine placenta.,2025,10.1016/j.placenta.2025.05.017,https://pubmed.ncbi.nlm.nih.gov/40435666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,38126142,Participation of the TBP-associated factors (TAFs) in cell differentiation.,2024,10.1002/jcp.31167,https://pubmed.ncbi.nlm.nih.gov/38126142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,34552771,Current updates and future perspectives in the evaluation of azoospermia: A systematic review.,2021,10.1080/2090598x.2021.1954415,https://pubmed.ncbi.nlm.nih.gov/34552771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,34821436,A novel immunodiagnosis panel for hepatocellular carcinoma based on bioinformatics and the autoantibody-antigen system.,2022,10.1111/cas.15217,https://pubmed.ncbi.nlm.nih.gov/34821436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,36142875,Gene Expression and DNA Methylation in Human Papillomavirus Positive and Negative Head and Neck Squamous Cell Carcinomas.,2022,10.3390/ijms231810967,https://pubmed.ncbi.nlm.nih.gov/36142875/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,31914128,Dynamic and regulated TAF gene expression during mouse embryonic germ cell development.,2020,10.1371/journal.pgen.1008515,https://pubmed.ncbi.nlm.nih.gov/31914128/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,24082143,Taf7l cooperates with Trf2 to regulate spermiogenesis.,2013,10.1073/pnas.1317034110,https://pubmed.ncbi.nlm.nih.gov/24082143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,27576952,TRF2 is recruited to the pre-initiation complex as a testis-specific subunit of TFIIA/ALF to promote haploid cell gene expression.,2016,10.1038/srep32069,https://pubmed.ncbi.nlm.nih.gov/27576952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,26107214,Cancer/Testis OIP5 and TAF7L Genes are Up-Regulated in Breast Cancer.,2015,10.7314/apjcp.2015.16.11.4623,https://pubmed.ncbi.nlm.nih.gov/26107214/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,23292864,"Expression analysis of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L in acute myeloid leukemia: a gender-dependent expression pattern.",2013,10.1007/s12032-012-0368-8,https://pubmed.ncbi.nlm.nih.gov/23292864/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,23326641,Dual functions of TAF7L in adipocyte differentiation.,2013,10.7554/elife.00170,https://pubmed.ncbi.nlm.nih.gov/23326641/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,38511217,Systematic molecular analyses for 115 karyotypically normal men with isolated non-obstructive azoospermia.,2024,10.1093/humrep/deae057,https://pubmed.ncbi.nlm.nih.gov/38511217/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,25975716,Non-synonymous mutations mapped to chromosome X associated with andrological and growth traits in beef cattle.,2015,10.1186/s12864-015-1595-0,https://pubmed.ncbi.nlm.nih.gov/25975716/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAF7L,ENSG00000102387,Unsafe,11279525,An abundance of X-linked genes expressed in spermatogonia.,2001,10.1038/86927,https://pubmed.ncbi.nlm.nih.gov/11279525/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAFA3,ENSG00000184599,Unsafe,35712659,"Molecular Structure, Expression and Role of TAFA4 and its Receptor FPR1 in the Spinal Cord.",2022,10.3389/fcell.2022.911414,https://pubmed.ncbi.nlm.nih.gov/35712659/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAFA3,ENSG00000184599,Unsafe,25595455,"FAM19A3, a novel secreted protein, modulates the microglia/macrophage polarization dynamics and ameliorates cerebral ischemia.",2015,10.1016/j.febslet.2015.01.003,https://pubmed.ncbi.nlm.nih.gov/25595455/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAFA3,ENSG00000184599,Unsafe,25562418,High-resolution 400K oligonucleotide array comparative genomic hybridization analysis of neurofibromatosis type 1-associated cutaneous neurofibromas.,2015,10.1016/j.gene.2014.12.064,https://pubmed.ncbi.nlm.nih.gov/25562418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TAFA3,ENSG00000184599,Unsafe,15028294,TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain.,2004,10.1016/j.ygeno.2003.10.006,https://pubmed.ncbi.nlm.nih.gov/15028294/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TATDN2,ENSG00000157014,Unsafe,41404808,Tatdn2 is required for DNA repair to safeguard genome stability in primordial germ cells.,2025,10.1093/nar/gkaf1289,https://pubmed.ncbi.nlm.nih.gov/41404808/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TATDN2,ENSG00000157014,Unsafe,37953292,TATDN2 resolution of R-loops is required for survival of BRCA1-mutant cancer cells.,2023,10.1093/nar/gkad952,https://pubmed.ncbi.nlm.nih.gov/37953292/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TATDN2,ENSG00000157014,Unsafe,37696853,"Linkage analysis using whole exome sequencing data implicates SLC17A1, SLC17A3, TATDN2 and TMEM131L in type 1 diabetes in Kuwaiti families.",2023,10.1038/s41598-023-42255-2,https://pubmed.ncbi.nlm.nih.gov/37696853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TATDN2,ENSG00000157014,Unsafe,40784251,Evolutionary analysis of ghrelin in Actinopterygii.,2025,10.1016/j.cbd.2025.101599,https://pubmed.ncbi.nlm.nih.gov/40784251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TATDN2,ENSG00000157014,Unsafe,38069223,Cellular Responses to Widespread DNA Replication Stress.,2023,10.3390/ijms242316903,https://pubmed.ncbi.nlm.nih.gov/38069223/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TATDN2,ENSG00000157014,Unsafe,37087456,Development of an endoplasmic reticulum stress-related signature with potential implications in prognosis and immunotherapy in head and neck squamous cell carcinoma.,2023,10.1186/s13000-023-01338-4,https://pubmed.ncbi.nlm.nih.gov/37087456/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TATDN2,ENSG00000157014,Unsafe,18954468,"Complex organisation and structure of the ghrelin antisense strand gene GHRLOS, a candidate non-coding RNA gene.",2008,10.1186/1471-2199-9-95,https://pubmed.ncbi.nlm.nih.gov/18954468/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TATDN2,ENSG00000157014,Unsafe,32128678,Establishment of a Genomic-Clinicopathologic Nomogram for Predicting Early Recurrence of Hepatocellular Carcinoma After R0 Resection.,2021,10.1007/s11605-020-04554-1,https://pubmed.ncbi.nlm.nih.gov/32128678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TATDN2,ENSG00000157014,Unsafe,16211299,Identification of candidate radioresistant genes in human squamous cell carcinoma cells through gene expression analysis using DNA microarrays.,2005,10.3892/or.14.5.1293,https://pubmed.ncbi.nlm.nih.gov/16211299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42697995,Spatial isoform sequencing at single-cell resolution reveals cell-type-specific spatial isoform variability in multiple brain cell types.,2026,10.1038/s41592-026-03211-w,https://pubmed.ncbi.nlm.nih.gov/42697995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42542656,Evaluating exon skipping in the central nervous system in Duchenne muscular dystrophy using spatial transcriptomics.,2026,10.1016/j.isci.2026.116906,https://pubmed.ncbi.nlm.nih.gov/42542656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42435768,Single-Cell and Spatial Transcriptomics Unveil Key Regulators Governing Cell Differentiation for Schistosoma japonicum Sexual Development.,2026,10.1002/advs.76329,https://pubmed.ncbi.nlm.nih.gov/42435768/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42310461,Spatial distribution of the proteome in the human body and in cancers.,2026,10.1038/s41586-026-10660-y,https://pubmed.ncbi.nlm.nih.gov/42310461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42615563,A multiplex tissue resource for high-resolution spatial protein profiling in the Human Protein Atlas.,2026,10.1002/pro.70764,https://pubmed.ncbi.nlm.nih.gov/42615563/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42462710,Whole-transcriptome-scale isoform-resolved spatial imaging of single cells in tissues.,2026,10.1016/j.cell.2026.06.027,https://pubmed.ncbi.nlm.nih.gov/42462710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42419284,Dissecting human organ development using spatial technologies.,2026,10.1016/j.devcel.2026.05.004,https://pubmed.ncbi.nlm.nih.gov/42419284/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42374103,A unified spatial transcriptome profiling of ten mouse organs.,2026,10.1038/s41597-026-07752-9,https://pubmed.ncbi.nlm.nih.gov/42374103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42760317,Spatial proteomics identifies FXYD6 as a dual-site protein of neuromuscular junction in the diaphragm.,2026,10.1038/s42003-026-10884-8,https://pubmed.ncbi.nlm.nih.gov/42760317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42777040,Spatial organization of AQP4 water channel expression in the human brain.,2026,10.1126/sciadv.aeg8117,https://pubmed.ncbi.nlm.nih.gov/42777040/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42786290,ResolVI: addressing noise and bias in spatial transcriptomics.,2026,10.1038/s41592-026-03212-9,https://pubmed.ncbi.nlm.nih.gov/42786290/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42263412,Beyond the gene: isoform diversity as a key contributor to human brain disorders.,2026,10.1016/j.gde.2026.102497,https://pubmed.ncbi.nlm.nih.gov/42263412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42608546,Profiling maize embryonic leaf development and discovering new genes using high-resolution spatial long-read isoform sequencing.,2026,10.1038/s41477-026-02364-y,https://pubmed.ncbi.nlm.nih.gov/42608546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42781193,Benign Uroandrological Ecosystem: A Thorough Overview from Single-Cell and Spatial Transcriptomics.,2026,10.34133/research.1438,https://pubmed.ncbi.nlm.nih.gov/42781193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42222651,"ApoE expression across the CNS: Who, What, Where, When, and How (much)?",2026,10.1186/s44477-026-00028-x,https://pubmed.ncbi.nlm.nih.gov/42222651/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42609318,Tumor-neuronal hybrid programs reveal a spatially adaptive malignant state in glioblastoma.,2026,10.3389/fonc.2026.1865999,https://pubmed.ncbi.nlm.nih.gov/42609318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42458406,ViMST: vision transformer-based dual modality multi-task graph contrastive network for spatial transcriptomics microenvironments investigation.,2026,10.1186/s12915-026-02676-7,https://pubmed.ncbi.nlm.nih.gov/42458406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42754563,CoxFormer enables spatial omics inference with multimodal generative modeling.,2026,10.1038/s41467-026-76404-8,https://pubmed.ncbi.nlm.nih.gov/42754563/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42478573,Spatial Total RNA Sequencing of Formalin-Fixed Paraffin-Embedded Tissue by spRandom-seq.,2026,10.1002/smll.74487,https://pubmed.ncbi.nlm.nih.gov/42478573/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42454497,"The splice of life: an isoform-centric view of disease, technology, and therapeutics.",2026,10.1172/jci207476,https://pubmed.ncbi.nlm.nih.gov/42454497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42807800,Navigating the immunosuppressive abyss: current hurdles and innovative breakthroughs in neoadjuvant immunotherapy for osteosarcoma.,2026,10.3389/fimmu.2026.1837053,https://pubmed.ncbi.nlm.nih.gov/42807800/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42820221,Beyond local control: radiotherapy-immunotherapy combinations from &lt;i&gt;in situ&lt;/i&gt; vaccination to systemic immune remodeling.,2026,10.3389/fgene.2026.1927654,https://pubmed.ncbi.nlm.nih.gov/42820221/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42662135,Biomarker-driven immunotherapy and adoptive cell therapy in recurrent pancreatic ductal adenocarcinoma.,2026,10.3389/fmed.2026.1900701,https://pubmed.ncbi.nlm.nih.gov/42662135/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42792661,"Immunotherapy for Digestive System Cancers: Progress, Challenges, and Future Directions.",2026,10.3390/biomedicines14091919,https://pubmed.ncbi.nlm.nih.gov/42792661/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42317269,"Precision immuno-oncology in oral cancer: latest trends in biomarkers, novel drug development and nanoparticle-based therapeutic platforms.",2026,10.3389/fcell.2026.1839508,https://pubmed.ncbi.nlm.nih.gov/42317269/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42558893,Targeting molecular residual disease and immune escape in colorectal cancer recurrence: biomarker-guided immunotherapy and cell therapies.,2026,10.3389/fmed.2026.1906283,https://pubmed.ncbi.nlm.nih.gov/42558893/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42643613,Rethinking PDAC: from immunological silence to therapeutic opportunity.,2026,10.3389/fimmu.2026.1909191,https://pubmed.ncbi.nlm.nih.gov/42643613/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42787418,"Molecular subgroups and biomarker guided precision immunotherapy in triple-negative breast cancer: advances, challenges, and future directions.",2026,10.3389/fimmu.2026.1859601,https://pubmed.ncbi.nlm.nih.gov/42787418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42449707,"Rational Immune Checkpoint Inhibitor-Based Combination Immunotherapy in Cancer: Mechanistic Design, Biomarker Selection, and Implications for Oncology Pharmacy.",2026,10.3390/cancers18132163,https://pubmed.ncbi.nlm.nih.gov/42449707/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42352533,The Evolving Landscape of Immune Regulation and Immunotherapy in Cholangiocarcinoma and Biliary Tract Cancer.,2026,10.3390/cancers18122001,https://pubmed.ncbi.nlm.nih.gov/42352533/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42606129,Radiotherapy and immunotherapy in cancer treatment: mechanisms of clinical synergy.,2026,10.1172/jci207550,https://pubmed.ncbi.nlm.nih.gov/42606129/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42459678,"Immunotherapy for tuberculosis: current landscape, mechanistic insights, and translational perspectives.",2026,10.3389/fimmu.2026.1859046,https://pubmed.ncbi.nlm.nih.gov/42459678/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,41851770,"Precision immunotherapy for head and neck cancer: therapeutic combinations, biomarker strategies, and translational challenges.",2026,10.1186/s12943-026-02609-6,https://pubmed.ncbi.nlm.nih.gov/41851770/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42035063,"Breast cancer immunotherapy: mechanisms of immune evasion, biomarkers, and emerging therapeutic strategies.",2026,10.1186/s12943-026-02655-0,https://pubmed.ncbi.nlm.nih.gov/42035063/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42719683,"Tumor microenvironment-mediated resistance to immune checkpoint inhibitors in non-small cell lung cancer: Mechanisms, combination strategies and clinical perspectives (Review).",2026,10.3892/mco.2026.2971,https://pubmed.ncbi.nlm.nih.gov/42719683/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,41892350,Precision Immunotherapeutics for Glioblastoma: Current Approaches and Emerging Strategies in 2026.,2026,10.3390/cells15060561,https://pubmed.ncbi.nlm.nih.gov/41892350/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42807818,Engineering strategies to address immune and delivery barriers in pancreatic ductal adenocarcinoma: a barrier-matched translational framework.,2026,10.3389/fimmu.2026.1900936,https://pubmed.ncbi.nlm.nih.gov/42807818/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42206056,Unlocking the potential: current landscape and future directions of immunotherapy in gastric cancer.,2026,10.3389/fimmu.2026.1742723,https://pubmed.ncbi.nlm.nih.gov/42206056/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42734102,Spatial and Temporal Heterogeneity of Macrophage Efferocytosis in Tumors: Emerging Implications for Immunotherapy Biomarkers and Therapeutic Timing.,2026,10.1002/cam4.72195,https://pubmed.ncbi.nlm.nih.gov/42734102/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBATA,ENSG00000166220,Unsafe,42736558,Spatial ecotype in tumor immune exclusion: from spatial architecture to therapeutic strategies.,2026,10.1186/s12943-026-02766-8,https://pubmed.ncbi.nlm.nih.gov/42736558/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D26,ENSG00000214946,Unsafe,41656195,PPP1R1C: a specific placental mRNA biomarker for distinguishing preeclampsia from healthy pregnancies.,2026,10.1186/s12884-026-08779-x,https://pubmed.ncbi.nlm.nih.gov/41656195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D3D,ENSG00000274419,Unsafe,41882721,Pharmacogenomic study of the effects of saxagliptin on glucose control and hypoglycemic events.,2026,10.1186/s12920-026-02348-z,https://pubmed.ncbi.nlm.nih.gov/41882721/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D3D,ENSG00000274419,Unsafe,34553038,TBC1D3 family is a prognostic biomarker and correlates with immune infiltration in kidney renal clear cell carcinoma.,2021,10.1016/j.omto.2021.06.014,https://pubmed.ncbi.nlm.nih.gov/34553038/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D3D,ENSG00000274419,Unsafe,16863688,"TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.",2006,10.1016/j.ygeno.2006.05.009,https://pubmed.ncbi.nlm.nih.gov/16863688/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D3G,ENSG00000260287,Unsafe,33074126,Characterization of stanniocalcin-1 expression in macrophage differentiation.,2021,10.1016/j.tranon.2020.100881,https://pubmed.ncbi.nlm.nih.gov/33074126/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,42481897,Correlations between TSC Expression and Menorrhagia in Adenomyosis Patients.,2026,10.1007/s43032-026-02141-4,https://pubmed.ncbi.nlm.nih.gov/42481897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,40655946,New insights into tuberous sclerosis complex: from structure to pathogenesis.,2025,10.3389/fcell.2025.1595867,https://pubmed.ncbi.nlm.nih.gov/40655946/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,42204603,"AcTor, a novel mTOR stimulator, potentiates ixazomib for the treatment of acute myeloid leukemia.",2026,10.1186/s12943-026-02689-4,https://pubmed.ncbi.nlm.nih.gov/42204603/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,39231952,TBC1 domain-containing proteins are frequently involved in triple-negative breast cancers in connection with the induction of a glycolytic phenotype.,2024,10.1038/s41419-024-07037-2,https://pubmed.ncbi.nlm.nih.gov/39231952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,40597935,Integrated proteomics and transcriptomics analysis reveals key regulatory genes between ER-positive/PR-positive and ER-positive/PR-negative breast cancer.,2025,10.1186/s12885-025-14451-y,https://pubmed.ncbi.nlm.nih.gov/40597935/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,39940906,Integrated Computational Analysis Reveals Early Genetic and Epigenetic AML Susceptibility Biomarkers in Benzene-Exposed Workers.,2025,10.3390/ijms26031138,https://pubmed.ncbi.nlm.nih.gov/39940906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,35584673,The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth.,2022,10.1016/j.celrep.2022.110824,https://pubmed.ncbi.nlm.nih.gov/35584673/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,38809988,Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer.,2024,10.1126/sciadv.adk3121,https://pubmed.ncbi.nlm.nih.gov/38809988/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,35077870,TBC domain family 7-like enhances the tolerance of Penaeus vannamei to ammonia nitrogen by the up-regulation of autophagy.,2022,10.1016/j.fsi.2022.01.025,https://pubmed.ncbi.nlm.nih.gov/35077870/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,40118904,Mining of candidate genes related to body size in Chinese native pig breeds based on public data.,2025,10.1038/s41598-025-88583-3,https://pubmed.ncbi.nlm.nih.gov/40118904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,40282429,Clinical-Genetic Approach to Conditions with Macrocephaly and ASD/Behaviour Abnormalities: Variants in &lt;i&gt;PTEN&lt;/i&gt; and &lt;i&gt;PPP2R5D&lt;/i&gt; Are the Most Recurrent Gene Mutations in a Patient-Oriented Diagnostic Strategy.,2025,10.3390/genes16040469,https://pubmed.ncbi.nlm.nih.gov/40282429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,37371794,Transcriptomic Context of RUNX3 Expression in Monocytes: A Cross-Sectional Analysis.,2023,10.3390/biomedicines11061698,https://pubmed.ncbi.nlm.nih.gov/37371794/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,32510182,Discovery of TBC1D7 as a Potential Driver for Melanoma Cell Invasion.,2020,10.1002/pmic.201900347,https://pubmed.ncbi.nlm.nih.gov/32510182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,35096832,Beyond Protein Synthesis; The Multifaceted Roles of Tuberin in Cell Cycle Regulation.,2021,10.3389/fcell.2021.806521,https://pubmed.ncbi.nlm.nih.gov/35096832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,37769522,Increasing glutathione levels by a novel posttranslational mechanism inhibits neuronal hyperexcitability.,2023,10.1016/j.redox.2023.102895,https://pubmed.ncbi.nlm.nih.gov/37769522/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,29187524,dTBC1D7 regulates systemic growth independently of TSC through insulin signaling.,2018,10.1083/jcb.201706027,https://pubmed.ncbi.nlm.nih.gov/29187524/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,30143532,The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding.,2018,10.1074/jbc.ra118.003525,https://pubmed.ncbi.nlm.nih.gov/30143532/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,35764790,Equivocal evidence for a link between megalencephaly-related genes and primate brain size evolution.,2022,10.1038/s41598-022-12953-4,https://pubmed.ncbi.nlm.nih.gov/35764790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,33436626,Structural insights into TSC complex assembly and GAP activity on Rheb.,2021,10.1038/s41467-020-20522-4,https://pubmed.ncbi.nlm.nih.gov/33436626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,33194704,Tre2-Bub2-Cdc16 Family Proteins Based Nomogram Serve as a Promising Prognosis Predicting Model for Melanoma.,2020,10.3389/fonc.2020.579625,https://pubmed.ncbi.nlm.nih.gov/33194704/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,42603235,Candidate genomic regions associated with differential clinical response to lumpy skin disease in sahiwal cattle.,2026,10.1007/s11259-026-11464-1,https://pubmed.ncbi.nlm.nih.gov/42603235/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,27795403,The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA.,2016,10.1128/mbio.01747-16,https://pubmed.ncbi.nlm.nih.gov/27795403/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBC1D7,ENSG00000145979,Unsafe,17658474,Identification of TBC7 having TBC domain as a novel binding protein to TSC1-TSC2 complex.,2007,10.1016/j.bbrc.2007.07.011,https://pubmed.ncbi.nlm.nih.gov/17658474/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,42876469,Types 1 diabetes mellitus and Graves' disease in Sanjad-Sakati syndrome: a case report in Saudi Arabia.,2026,10.3389/fendo.2026.1920847,https://pubmed.ncbi.nlm.nih.gov/42876469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,41833177,Clinical-genetic features of the TBCE-related spectrum disorders: A focus on the childhood-onset neurodegenerative phenotype.,2026,10.1016/j.ymgme.2026.109873,https://pubmed.ncbi.nlm.nih.gov/41833177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,42267904,Comprehensive analysis of disease spectrum and mortality in Sanjad-Sakati syndrome: an international rare disease registry study.,2026,10.1210/clinem/dgag226,https://pubmed.ncbi.nlm.nih.gov/42267904/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,41461644,Cryo-EM structures of the tubulin cofactors reveal the molecular basis of alpha/beta-tubulin biogenesis.,2025,10.1038/s41467-025-68142-0,https://pubmed.ncbi.nlm.nih.gov/41461644/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,42102195,A unified mechanism for tubulin cofactors catalyzing α/β-tubulin biogenesis and degradation.,2026,10.1126/sciadv.aee2303,https://pubmed.ncbi.nlm.nih.gov/42102195/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,39153170,"Expanding TBCE-related phenotype-novel variant causing rigid spine, eosinophilia, neutropenia, and nocturnal hypoxemia.",2025,10.1007/s13353-024-00894-9,https://pubmed.ncbi.nlm.nih.gov/39153170/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,39657131,Out-of-frame Translation Rescues a Loss-of-function Variant in a Novel TBCE Phenotype.,2025,10.1210/clinem/dgae839,https://pubmed.ncbi.nlm.nih.gov/39657131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,39932783,Quantitative hypermorphic FAM111A alleles cause autosomal recessive Kenny-Caffey syndrome type 2 and osteocraniostenosis.,2025,10.1172/jci.insight.186862,https://pubmed.ncbi.nlm.nih.gov/39932783/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,39911167,Key Clinical and X-Ray Characteristics for the Diagnosis of Kenny-Caffey Syndrome Types 1 and 2.,2025,10.1159/000540377,https://pubmed.ncbi.nlm.nih.gov/39911167/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,39086450,Homozygous TBCE Gene Mutation c.155-166del in a Libyan Patient with Sanjad-Sakati Syndrome: Same Gene Mutation Responsible in All Arab Ethnic Patients.,2024,10.1055/s-0042-1744482,https://pubmed.ncbi.nlm.nih.gov/39086450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,40856104,"A founder variant in TBCB is associated with global developmental delay, autism spectrum, and spastic paraparesis.",2025,10.1016/j.gim.2025.101569,https://pubmed.ncbi.nlm.nih.gov/40856104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,33968934,"Colchicine Blocks Tubulin Heterodimer Recycling by Tubulin Cofactors TBCA, TBCB, and TBCE.",2021,10.3389/fcell.2021.656273,https://pubmed.ncbi.nlm.nih.gov/33968934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,40037090,"Oligogenic analysis across broad phenotypes of 46,XY differences in sex development associated with NR5A1/SF-1 variants: findings from the international SF1next study.",2025,10.1016/j.ebiom.2025.105624,https://pubmed.ncbi.nlm.nih.gov/40037090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,40715829,The role of mitochondria-related genes in hepatocellular carcinoma prognosis: construction of prognostic models based on machine learning.,2025,10.1007/s12672-025-03216-5,https://pubmed.ncbi.nlm.nih.gov/40715829/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,36970197,Concurrent silencing of TBCE and drug delivery to overcome platinum-based resistance in liver cancer.,2023,10.1016/j.apsb.2022.03.003,https://pubmed.ncbi.nlm.nih.gov/36970197/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,39853547,Phenotypic variability in progressive encephalopathy with brain atrophy and thin corpus callosum: insights from two families.,2025,10.1007/s10048-025-00799-7,https://pubmed.ncbi.nlm.nih.gov/39853547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,38433956,Sanjad-Sakati Syndrome in a 35-day-old Iraqi Infant: A Case Report.,2024,10.5001/omj.2024.09,https://pubmed.ncbi.nlm.nih.gov/38433956/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,34132336,Tubulin-folding cofactor E deficiency promotes vascular dysfunction by increased endoplasmic reticulum stress.,2022,10.1093/eurheartj/ehab222,https://pubmed.ncbi.nlm.nih.gov/34132336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,35432193,Disorders of Sex Development in a Large Ukrainian Cohort: Clinical Diversity and Genetic Findings.,2022,10.3389/fendo.2022.810782,https://pubmed.ncbi.nlm.nih.gov/35432193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,34134906,Broadening the spectrum phenotype of TBCE-related neuron neurodegeneration.,2021,10.1016/j.braindev.2021.05.015,https://pubmed.ncbi.nlm.nih.gov/34134906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,35720065,Pegylated Insulin-Like Growth Factor 1 attenuates Hair Cell Loss and promotes Presynaptic Maintenance of Medial Olivocochlear Cholinergic Fibers in the Cochlea of the Progressive Motor Neuropathy Mouse.,2022,10.3389/fneur.2022.885026,https://pubmed.ncbi.nlm.nih.gov/35720065/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,36916904,Expanding the Phenotypic Spectrum of Kenny-Caffey Syndrome.,2023,10.1210/clinem/dgad147,https://pubmed.ncbi.nlm.nih.gov/36916904/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,33150438,Multiple Endocrine Deficiencies are Common in Hypoparathyroidism-Retardation-Dysmorphism Syndrome.,2021,10.1210/clinem/dgaa807,https://pubmed.ncbi.nlm.nih.gov/33150438/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,28004224,Antioxidant and antiproliferative effects of different solvent fractions from Terminalia belerica Roxb. fruit on various cancer cells.,2017,10.1007/s10616-016-0051-6,https://pubmed.ncbi.nlm.nih.gov/28004224/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,32652002,A Genome-Wide Pharmacogenetic Study of Growth Hormone Responsiveness.,2020,10.1210/clinem/dgaa443,https://pubmed.ncbi.nlm.nih.gov/32652002/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,27021905,Neurofilament depletion improves microtubule dynamics via modulation of Stat3/stathmin signaling.,2016,10.1007/s00401-016-1564-y,https://pubmed.ncbi.nlm.nih.gov/27021905/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,28582460,Admixture mapping of pelvic organ prolapse in African Americans from the Women's Health Initiative Hormone Therapy trial.,2017,10.1371/journal.pone.0178839,https://pubmed.ncbi.nlm.nih.gov/28582460/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCE,ENSG00000284770,Unsafe,20103624,Efficacious immune therapy in chronic myelogenous leukemia (CML) recognizes antigens that are expressed on CML progenitor cells.,2010,10.1158/0008-5472.can-09-2303,https://pubmed.ncbi.nlm.nih.gov/20103624/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCEL,ENSG00000154114,Unsafe,32033965,"Tubulin-binding cofactor E-like (TBCEL), the protein product of the mulet gene, is required in the germline for the regulation of inter-flagellar microtubule dynamics during spermatid individualization.",2020,10.1242/bio.049080,https://pubmed.ncbi.nlm.nih.gov/32033965/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCEL,ENSG00000154114,Unsafe,37632589,Whole-Genome Re-sequencing and Transcriptome Reveal Candidate Genes and Pathways Associated with Hybrid Sterility in Hermaphroditic Argopecten Scallops.,2023,10.1007/s10126-023-10247-y,https://pubmed.ncbi.nlm.nih.gov/37632589/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCEL,ENSG00000154114,Unsafe,23121292,The Drosophila homologue of tubulin-specific chaperone E-like protein is required for synchronous sperm individualization and normal male fertility.,2012,10.3109/01677063.2012.731119,https://pubmed.ncbi.nlm.nih.gov/23121292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCEL,ENSG00000154114,Unsafe,24098140,Identification of 526 conserved metazoan genetic innovations exposes a new role for cofactor E-like in neuronal microtubule homeostasis.,2013,10.1371/journal.pgen.1003804,https://pubmed.ncbi.nlm.nih.gov/24098140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCEL,ENSG00000154114,Unsafe,18439319,Multiple expressed MHC class II loci in salmonids; details of one non-classical region in Atlantic salmon (Salmo salar).,2008,10.1186/1471-2164-9-193,https://pubmed.ncbi.nlm.nih.gov/18439319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBCEL,ENSG00000154114,Unsafe,15728251,Identification of a novel tubulin-destabilizing protein related to the chaperone cofactor E.,2005,10.1242/jcs.01719,https://pubmed.ncbi.nlm.nih.gov/15728251/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,41101043,TBL2 modulates glioblastoma progression by inducing autophagy through by the AMPK/mTOR signaling pathway.,2026,10.1016/j.tice.2025.103186,https://pubmed.ncbi.nlm.nih.gov/41101043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,39499734,TBL2 Promotes Tumorigenesis via PRMT5/WDR77-Mediated AKT Activation in Breast Cancer.,2024,10.1002/advs.202400160,https://pubmed.ncbi.nlm.nih.gov/39499734/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,37477745,Transducin Beta-Like 2 is a Potential Driver Gene that Adapts to Endoplasmic Reticulum Stress to Promote Tumor Growth of Lung Adenocarcinoma.,2023,10.1245/s10434-023-13864-y,https://pubmed.ncbi.nlm.nih.gov/37477745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,40841581,Early lipid genetics: identification of common and rare genetic variants for lipid traits in Indian adolescents.,2025,10.1038/s10038-025-01388-0,https://pubmed.ncbi.nlm.nih.gov/40841581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,32811528,TBL2 methylation is associated with hyper-low-density lipoprotein cholesterolemia: a case-control study.,2020,10.1186/s12944-020-01359-8,https://pubmed.ncbi.nlm.nih.gov/32811528/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,36356568,Transcriptomic and proteomic characteristics of the di(2-ethylhexyl) phthalate-induced sperm dna damage mouse model.,2022,10.1177/09603271221139444,https://pubmed.ncbi.nlm.nih.gov/36356568/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,37254524,Integrating functional scoring and regulatory data to predict the effect of non-coding SNPs in a complex neurological disease.,2024,10.1093/bfgp/elad020,https://pubmed.ncbi.nlm.nih.gov/37254524/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,34015761,PKD2 deficiency suppresses amino acid biosynthesis in ADPKD by impairing the PERK-TBL2-eIF2ɑ-ATF4 pathway.,2021,10.1016/j.bbrc.2021.05.012,https://pubmed.ncbi.nlm.nih.gov/34015761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,33789571,An introduction to new robust linear and monotonic correlation coefficients.,2021,10.1186/s12859-021-04098-4,https://pubmed.ncbi.nlm.nih.gov/33789571/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,36768954,Modulation of NBAS-Related Functions in the Early Response to SARS-CoV-2 Infection.,2023,10.3390/ijms24032634,https://pubmed.ncbi.nlm.nih.gov/36768954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,35285134,Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations.,2022,10.1111/jth.15698,https://pubmed.ncbi.nlm.nih.gov/35285134/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,34698247,Novel Binding Partners for CCT and PhLP1 Suggest a Common Folding Mechanism for WD40 Proteins with a 7-Bladed Beta-Propeller Structure.,2021,10.3390/proteomes9040040,https://pubmed.ncbi.nlm.nih.gov/34698247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,35864917,Seropositive Neuromyelitis Optica in a Case of Undiagnosed Ankylosing Spondylitis: A Neuro-Rheumatological Conundrum.,2022,10.5339/qmj.2022.29,https://pubmed.ncbi.nlm.nih.gov/35864917/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,28196854,Hypothalamic transcriptomic alterations in male and female California mice (Peromyscus californicus) developmentally exposed to bisphenol A or ethinyl estradiol.,2017,10.14814/phy2.13133,https://pubmed.ncbi.nlm.nih.gov/28196854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,26239904,TBL2 Associates With ATF4 mRNA Via Its WD40 Domain and Regulates Its Translation During ER Stress.,2016,10.1002/jcb.25301,https://pubmed.ncbi.nlm.nih.gov/26239904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,30902786,MicroRNA 4651 regulates nonsense-mediated mRNA decay by targeting SMG9 mRNA.,2019,10.1016/j.gene.2019.03.031,https://pubmed.ncbi.nlm.nih.gov/30902786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,25393282,TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress.,2014,10.1371/journal.pone.0112761,https://pubmed.ncbi.nlm.nih.gov/25393282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,25976671,The endoplasmic reticulum-localized protein TBL2 interacts with the 60S ribosomal subunit.,2015,10.1016/j.bbrc.2015.04.144,https://pubmed.ncbi.nlm.nih.gov/25976671/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,27473591,MicroRNA 433 regulates nonsense-mediated mRNA decay by targeting SMG5 mRNA.,2016,10.1186/s12867-016-0070-z,https://pubmed.ncbi.nlm.nih.gov/27473591/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,33965896,Exercise training effects on natural killer cells: a preliminary proteomics and systems biology approach.,2021,,https://pubmed.ncbi.nlm.nih.gov/33965896/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,40644570,&lt;sup&gt;1&lt;/sup&gt;H Parashift Probes for Ratiometric Detection of Nitroreductase.,2025,10.1021/acs.inorgchem.5c00798,https://pubmed.ncbi.nlm.nih.gov/40644570/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,26535170,First Bahraini adolescent with anti-NMDAR-Ab encephalitis.,2015,10.5339/qmj.2015.2,https://pubmed.ncbi.nlm.nih.gov/26535170/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TBL2,ENSG00000106638,Unsafe,18193044,"Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.",2008,10.1038/ng.75,https://pubmed.ncbi.nlm.nih.gov/18193044/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,41631087,Type 2 Diabetes in a Portuguese Adolescent With Hijazi-Reis Syndrome.,2026,10.7759/cureus.100610,https://pubmed.ncbi.nlm.nih.gov/41631087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,42058904,Dynamic systemic immune-inflammation index predicts survival after neoadjuvant immunotherapy in gastric cancer: A multicenter study.,2026,10.1016/j.isci.2026.115612,https://pubmed.ncbi.nlm.nih.gov/42058904/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,40250979,The USP11/TCEAL1 complex promotes transcription elongation to sustain oncogenic gene expression in neuroblastoma.,2025,10.1101/gad.352166.124,https://pubmed.ncbi.nlm.nih.gov/40250979/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,38200082,Confirmation and expansion of the phenotype of the TCEAL1-related neurodevelopmental disorder.,2024,10.1038/s41431-023-01530-6,https://pubmed.ncbi.nlm.nih.gov/38200082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,38750072,Xq22 deletion involving TCEAL1 in a female patient with early-onset neurological disease trait.,2024,10.1038/s41439-024-00278-9,https://pubmed.ncbi.nlm.nih.gov/38750072/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,36368327,TCEAL1 loss-of-function results in an X-linked dominant neurodevelopmental syndrome and drives the neurological disease trait in Xq22.2 deletions.,2022,10.1016/j.ajhg.2022.10.007,https://pubmed.ncbi.nlm.nih.gov/36368327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,36900258,Aberrant Methylation of the Imprinted C19MC and MIR371-3 Clusters in Patients with Non-Small Cell Lung Cancer.,2023,10.3390/cancers15051466,https://pubmed.ncbi.nlm.nih.gov/36900258/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,33033111,In vivo CRISPR/Cas9 knockout screen: TCEAL1 silencing enhances docetaxel efficacy in prostate cancer.,2020,10.26508/lsa.202000770,https://pubmed.ncbi.nlm.nih.gov/33033111/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,33613812,Hypoglycemic Effect of Electroacupuncture Combined with Antrodia cinnamomea in Dexamethasone-Induced Insulin-Resistant Rats.,2021,10.1089/acu.2020.1455,https://pubmed.ncbi.nlm.nih.gov/33613812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,33765582,Protein O-GlcNAcylation alleviates small intestinal injury induced by ischemia-reperfusion and oxygen-glucose deprivation.,2021,10.1016/j.biopha.2021.111477,https://pubmed.ncbi.nlm.nih.gov/33765582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,32297559,Electroacupuncture combined with acarbose improves insulin sensitivity via peroxisome proliferator-activated receptor γ activation and produces a stronger glucose-lowering effect than acarbose alone in a rat model of steroid-induced insulin resistance.,2020,10.1177/0964528419901135,https://pubmed.ncbi.nlm.nih.gov/32297559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,29257321,Improving insulin resistance with Antrodia cinnamomea mycelium powder to induce a hypoglycemic effect in dexamethasone‑induced insulin‑resistant rats.,2018,10.3892/mmr.2017.8259,https://pubmed.ncbi.nlm.nih.gov/29257321/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,27506666,"A microdeletion at Xq22.2 implicates a glycine receptor GLRA4 involved in intellectual disability, behavioral problems and craniofacial anomalies.",2016,10.1186/s12883-016-0642-z,https://pubmed.ncbi.nlm.nih.gov/27506666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,35280808,A Radiosensitivity Prediction Model Developed Based on Weighted Correlation Network Analysis of Hypoxia Genes for Lower-Grade Glioma.,2022,10.3389/fonc.2022.757686,https://pubmed.ncbi.nlm.nih.gov/35280808/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,26879182,15 Hz electroacupuncture at ST36 improves insulin sensitivity and reduces free fatty acid levels in rats with chronic dexamethasone-induced insulin resistance.,2016,10.1136/acupmed-2015-010956,https://pubmed.ncbi.nlm.nih.gov/26879182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,10051408,"Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR.",1999,10.1006/geno.1998.5705,https://pubmed.ncbi.nlm.nih.gov/10051408/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,24438349,Peroxisome proliferator-activated receptor activating hypoglycemic effect of Gardenia jasminoides Ellis aqueous extract and improvement of insulin sensitivity in steroid induced insulin resistant rats.,2014,10.1186/1472-6882-14-30,https://pubmed.ncbi.nlm.nih.gov/24438349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,25712886,The Involvement of Serotonin in the Hypoglycemic Effects Produced by Administration of the Aqueous Extract of Xylaria nigripes with Steroid-Induced Insulin-Resistant Rats.,2015,10.1002/ptr.5314,https://pubmed.ncbi.nlm.nih.gov/25712886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,26173897,Epidemic Model with Isolation in Multilayer Networks.,2015,10.1038/srep12151,https://pubmed.ncbi.nlm.nih.gov/26173897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,27179774,Screening of Differently Expressed miRNA and mRNA in Prostate Cancer by Integrated Analysis of Transcription Data.,2016,10.1016/j.urology.2016.04.041,https://pubmed.ncbi.nlm.nih.gov/27179774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,35800642,Does the sixth wave of COVID-19 break in Okinawa?,2022,10.1002/jgf2.550,https://pubmed.ncbi.nlm.nih.gov/35800642/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCEAL1,ENSG00000172465,Unsafe,34301560,The Rx-HEART Framework to Address Health Equity and Racism Within Pharmacy Education.,2021,10.5688/ajpe8590,https://pubmed.ncbi.nlm.nih.gov/34301560/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,42741451,High-dimensional spectral flow cytometry uncovers progressive T-cell exhaustion and myeloid cell reprogramming in a CLL mouse model.,2026,10.1002/hem3.70476,https://pubmed.ncbi.nlm.nih.gov/42741451/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,42503043,Reduced colony-stimulating factor 1 receptor expression in myeloid cells has limited impact on chronic lymphocytic leukaemia progression.,2026,10.1111/bjh.70700,https://pubmed.ncbi.nlm.nih.gov/42503043/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,42101063,Neither Fish nor Fowl-Cerebriform Variant of TCL1-Family Negative T-Prolymphocytic Leukemia.,2026,10.1111/ijlh.70140,https://pubmed.ncbi.nlm.nih.gov/42101063/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,41790574,CD49d governs immune synapse formation through actin rearrangements and synchronizes BCR signaling in CLL.,2026,10.1182/blood.2024027753,https://pubmed.ncbi.nlm.nih.gov/41790574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,42745818,Case Report: Blastic plasmacytoid dendritic cell neoplasm mimicking systemic lymphoma: a multidisciplinary diagnostic challenge.,2026,10.3389/fmed.2026.1934512,https://pubmed.ncbi.nlm.nih.gov/42745818/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,40696399,miR-193a-3p prevents tumour progression by targeting TCL1 in diffuse large B-cell lymphoma.,2025,10.1186/s12967-025-06689-8,https://pubmed.ncbi.nlm.nih.gov/40696399/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,42857718,Influence of gut microbiota on chronic lymphocytic leukemia development and aggressiveness.,2027,10.1080/29933935.2026.2717015,https://pubmed.ncbi.nlm.nih.gov/42857718/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,42553064,Impact of high-fat Western diet on chronic lymphocytic leukemia disease progression and gut microbiome profile in Eµ-TCL1 mice.,2026,10.3389/fonc.2026.1842275,https://pubmed.ncbi.nlm.nih.gov/42553064/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,41214147,IGHV1 usage is associated with lymphadenopathy and aggressive disease in the TCL1 mouse model for chronic lymphocytic leukemia.,2025,10.1038/s41598-025-23109-5,https://pubmed.ncbi.nlm.nih.gov/41214147/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,41545700,Strong constitutive NF-κB signaling in B cells drives SLL/CLL-like lymphomagenesis and overcomes microenvironmental dependencies.,2026,10.1038/s41375-025-02844-8,https://pubmed.ncbi.nlm.nih.gov/41545700/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,40994741,Eμ-TCL1 mice with conditional human BCL2 knockin as novel B-cell lymphoma model for studying venetoclax effects in vivo.,2025,10.1016/j.bneo.2025.100143,https://pubmed.ncbi.nlm.nih.gov/40994741/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,41163374,Targeting Tumorigenic Coactivators in the PI3K/AKT Signaling Pathway: A Novel Approach for Cancer Treatment.,2025,10.1002/cam4.71304,https://pubmed.ncbi.nlm.nih.gov/41163374/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,41954626,A case of T-prolymphocytic leukemia harboring RAS mutation.,2026,10.1007/s00277-026-06986-2,https://pubmed.ncbi.nlm.nih.gov/41954626/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,41939248,Casein kinase 1δ/ε inhibition suppresses CLL proliferation through cell-intrinsic and microenvironmental mechanisms.,2026,10.1002/hem3.70343,https://pubmed.ncbi.nlm.nih.gov/41939248/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,40720748,Targeting S100A9-mediated inflammation: a novel therapeutic approach for CLL.,2025,10.1182/bloodadvances.2025016061,https://pubmed.ncbi.nlm.nih.gov/40720748/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,40708600,BET Protein Inhibition Relieves MDSC-Mediated Immune Suppression in Chronic Lymphocytic Leukemia.,2025,10.3390/hemato6020014,https://pubmed.ncbi.nlm.nih.gov/40708600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,40742099,Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia.,2025,10.1158/2767-9764.crc-25-0022,https://pubmed.ncbi.nlm.nih.gov/40742099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,40376109,&lt;i&gt;Tcl1&lt;/i&gt; coordinately promotes metabolic shift and regulates totipotency exit.,2025,10.1093/lifemedi/lnaf013,https://pubmed.ncbi.nlm.nih.gov/40376109/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,39988601,G-protein coupled receptor kinase-2 regulates the migration of chronic lymphocytic leukaemia cells to sphingosine-1 phosphate in vitro and their trafficking in vivo.,2025,10.1038/s41598-025-91536-5,https://pubmed.ncbi.nlm.nih.gov/39988601/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,39157689,Robust and cost-effective CRISPR/Cas9 gene editing of primary tumor B cells in Eµ-TCL1 model of chronic lymphocytic leukemia.,2024,10.1002/hem3.134,https://pubmed.ncbi.nlm.nih.gov/39157689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,41773322,Splenic B-Cell Lymphoma/Leukemia With TCL1 Gene Rearrangement.,2026,10.1111/ijlh.70082,https://pubmed.ncbi.nlm.nih.gov/41773322/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,42454958,HS1 loss drives cytoskeletal dysregulation and reduces sensitivity to BTK inhibition in chronic lymphocytic leukemia.,2026,10.1093/jleuko/qiag099,https://pubmed.ncbi.nlm.nih.gov/42454958/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,42008303,The Clinicopathologic and Genomic Features of Mature Versus Blastic Plasmacytoid Dendritic Cell Neoplasms Arising From Chronic Myeloid Neoplasms.,2026,10.1097/pas.0000000000002556,https://pubmed.ncbi.nlm.nih.gov/42008303/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,38839457,Lessons learned from the Eµ-TCL1 mouse model of CLL.,2024,10.1053/j.seminhematol.2024.05.002,https://pubmed.ncbi.nlm.nih.gov/38839457/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,40917153,Real-world management of blastic plasmacytoid dendritic cell neoplasm at an academic center with a broad regional referral base.,2025,10.1016/j.lrr.2025.100541,https://pubmed.ncbi.nlm.nih.gov/40917153/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,41843069,T-prolymphocytic leukemia with three distinct immunophenotypic subsets.,2026,10.1007/s00428-026-04481-7,https://pubmed.ncbi.nlm.nih.gov/41843069/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,41575515,Blastic plasmacytoid dendritic cell neoplasm: dermal thickening with T2-dark band as an early imaging clue.,2026,10.1007/s00256-026-05140-3,https://pubmed.ncbi.nlm.nih.gov/41575515/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,10344735,Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus.,1999,,https://pubmed.ncbi.nlm.nih.gov/10344735/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCL1B,ENSG00000213231,Unsafe,10077617,Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes.,1999,10.1073/pnas.96.6.2949,https://pubmed.ncbi.nlm.nih.gov/10077617/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP10L,ENSG00000242220,Unsafe,40228222,NEK6 Accelerates Hepatocellular Carcinoma Progression and Glycolysis through Ubiquitination of TCP10L.,2025,10.1615/critreveukaryotgeneexpr.2025057446,https://pubmed.ncbi.nlm.nih.gov/40228222/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP10L,ENSG00000242220,Unsafe,32438969,TCP10L negatively regulates alpha-fetoprotein expression in hepatocellular carcinoma.,2020,,https://pubmed.ncbi.nlm.nih.gov/32438969/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP10L,ENSG00000242220,Unsafe,33947493,Whole-Genome Study of a Multigenerational Family with Essential Tremor.,2022,10.1017/cjn.2021.104,https://pubmed.ncbi.nlm.nih.gov/33947493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP10L,ENSG00000242220,Unsafe,31671693,Novel Mutations Segregating with Complete Androgen Insensitivity Syndrome and their Molecular Characteristics.,2019,10.3390/ijms20215418,https://pubmed.ncbi.nlm.nih.gov/31671693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP10L,ENSG00000242220,Unsafe,24565846,TCP10L acts as a tumor suppressor by inhibiting cell proliferation in hepatocellular carcinoma.,2014,10.1016/j.bbrc.2014.02.049,https://pubmed.ncbi.nlm.nih.gov/24565846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP10L,ENSG00000242220,Unsafe,26698869,TCP10L synergizes with MAD1 in transcriptional suppression and cell cycle arrest through mutual interaction.,2016,10.5483/bmbrep.2016.49.6.248,https://pubmed.ncbi.nlm.nih.gov/26698869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP10L,ENSG00000242220,Unsafe,15910542,TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3.,2005,10.1111/j.1365-2605.2005.00522.x,https://pubmed.ncbi.nlm.nih.gov/15910542/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP10L,ENSG00000242220,Unsafe,14586771,"Identification of a novel liver-specific expressed gene, TCP10L, encoding a human leucine zipper protein with transcription inhibition activity.",2003,10.1007/s10038-003-0075-6,https://pubmed.ncbi.nlm.nih.gov/14586771/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP10L,ENSG00000242220,Unsafe,15469726,Human liver specific transcriptional factor TCP10L binds to MAD4.,2004,10.5483/bmbrep.2004.37.4.402,https://pubmed.ncbi.nlm.nih.gov/15469726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCP11L1,ENSG00000176148,Unsafe,36036794,Associations of Heavy Metals with Activities of Daily Living Disability: An Epigenome-Wide View of DNA Methylation and Mediation Analysis.,2022,10.1289/ehp10602,https://pubmed.ncbi.nlm.nih.gov/36036794/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCTE1,ENSG00000146221,Unsafe,41460250,ANKEF1 is a key axonemal component essential for murine sperm motility and male fertility.,2025,10.7554/elife.105321,https://pubmed.ncbi.nlm.nih.gov/41460250/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCTE1,ENSG00000146221,Unsafe,38650655,Effects of &lt;i&gt;Tcte1&lt;/i&gt; knockout on energy chain transportation and spermatogenesis: implications for male infertility.,2024,10.1093/hropen/hoae020,https://pubmed.ncbi.nlm.nih.gov/38650655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCTE1,ENSG00000146221,Unsafe,35388187,Bi-allelic variants in human TCTE1/DRC5 cause asthenospermia and male infertility.,2022,10.1038/s41431-022-01095-w,https://pubmed.ncbi.nlm.nih.gov/35388187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCTE1,ENSG00000146221,Unsafe,31961863,Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice.,2020,10.1371/journal.pgen.1008585,https://pubmed.ncbi.nlm.nih.gov/31961863/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCTE1,ENSG00000146221,Unsafe,28630322,TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa.,2017,10.1073/pnas.1621279114,https://pubmed.ncbi.nlm.nih.gov/28630322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCTE1,ENSG00000146221,Unsafe,25761592,Comparative analysis of testis transcriptomes from triploid and fertile diploid cyprinid fish.,2015,10.1095/biolreprod.114.125609,https://pubmed.ncbi.nlm.nih.gov/25761592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCTE1,ENSG00000146221,Unsafe,20937862,Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma.,2010,10.1073/pnas.1003956107,https://pubmed.ncbi.nlm.nih.gov/20937862/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCTE1,ENSG00000146221,Unsafe,27440996,"Variation in PTCHD2, CRISP3, NAP1L4, FSCB, and AP3B2 associated with spherical equivalent.",2016,,https://pubmed.ncbi.nlm.nih.gov/27440996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCTE1,ENSG00000146221,Unsafe,8646886,"Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q.",1996,10.1159/000134329,https://pubmed.ncbi.nlm.nih.gov/8646886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCTE1,ENSG00000146221,Unsafe,2063871,The gene for autosomal dominant spinocerebellar ataxia (SCA1) maps telomeric to the HLA complex and is closely linked to the D6S89 locus in three large kindreds.,1991,,https://pubmed.ncbi.nlm.nih.gov/2063871/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TCTE1,ENSG00000146221,Unsafe,8352275,Linkage analysis of idiopathic generalized epilepsy (IGE) and marker loci on chromosome 6p in families of patients with juvenile myoclonic epilepsy: no evidence for an epilepsy locus in the HLA region.,1993,,https://pubmed.ncbi.nlm.nih.gov/8352275/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD10,ENSG00000163239,Unsafe,41514165,Integrated fetal testicular transcriptomic and epigenomic profiles during maternal nutrient restriction with dietary melatonin intervention.,2026,10.1093/jas/skaf455,https://pubmed.ncbi.nlm.nih.gov/41514165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD10,ENSG00000163239,Unsafe,36294892,Discovering Breast Cancer Biomarkers Candidates through mRNA Expression Analysis Based on The Cancer Genome Atlas Database.,2022,10.3390/jpm12101753,https://pubmed.ncbi.nlm.nih.gov/36294892/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD10,ENSG00000163239,Unsafe,37073353,Evolutionary dynamics and conserved function of the Tudor domain-containing (TDRD) proteins in teleost fish.,2022,10.1007/s42995-021-00118-7,https://pubmed.ncbi.nlm.nih.gov/37073353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD10,ENSG00000163239,Unsafe,30866861,Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers.,2019,10.1186/s12885-019-5403-0,https://pubmed.ncbi.nlm.nih.gov/30866861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD10,ENSG00000163239,Unsafe,25017056,Molecular analysis of porcine TDRD10 gene: a novel member of the TDRD family.,2014,10.1016/j.gene.2014.07.026,https://pubmed.ncbi.nlm.nih.gov/25017056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD10,ENSG00000163239,Unsafe,31832568,A Pilot Genome-Wide Analysis Study Identifies Loci Associated With Response to Obeticholic Acid in Patients With NASH.,2019,10.1002/hep4.1439,https://pubmed.ncbi.nlm.nih.gov/31832568/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD10,ENSG00000163239,Unsafe,24423473,Association of rs1466535 LRP1 but not rs3019885 SLC30A8 and rs6674171 TDRD10 gene polymorphisms with abdominal aortic aneurysm in Italian patients.,2015,10.1016/j.jvs.2013.10.090,https://pubmed.ncbi.nlm.nih.gov/24423473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD10,ENSG00000163239,Unsafe,39643267,"Genomic insights into demographic history, structural variation landscape, and complex traits from 514 Hu sheep genomes.",2025,10.1016/j.jgg.2024.11.015,https://pubmed.ncbi.nlm.nih.gov/39643267/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,42552473,TDRD5 facilitates piRNA biogenesis and male fertility through phase separation.,2026,10.1038/s44319-026-00890-6,https://pubmed.ncbi.nlm.nih.gov/42552473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,42531888,Ameliorative effects of myricetin nanoparticles on carbon tetrachloride-induced spermatogenic dysfunction in mice.,2026,10.1016/j.repbio.2026.101268,https://pubmed.ncbi.nlm.nih.gov/42531888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,42449406,Genetic architecture and cross-platform validation of apolipoprotein A-IV concentrations.,2026,10.1186/s13059-026-04196-7,https://pubmed.ncbi.nlm.nih.gov/42449406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,41655928,The Poly(rC) binding protein 2 is required for spermatogenesis by regulating alternative splicing and mRNA stability.,2026,10.1016/j.ijbiomac.2026.150796,https://pubmed.ncbi.nlm.nih.gov/41655928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,38520410,MIWI N-terminal arginines orchestrate generation of functional pachytene piRNAs and spermiogenesis.,2024,10.1093/nar/gkae193,https://pubmed.ncbi.nlm.nih.gov/38520410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,38847152,"Homozygous deleterious variants in the C-terminal of TDRD5 impair spermiogenesis, causing severe oligoasthenoteratozoospermia in humans.",2025,10.1111/andr.13676,https://pubmed.ncbi.nlm.nih.gov/38847152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,35323525,TDRD5 Is Required for Spermatogenesis and Oogenesis in Locusta migratoria.,2022,10.3390/insects13030227,https://pubmed.ncbi.nlm.nih.gov/35323525/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,39858587,Omics Data Integration Uncovers mRNA-miRNA Interaction Regions in Genes Associated with Chronic Venous Insufficiency.,2024,10.3390/genes16010040,https://pubmed.ncbi.nlm.nih.gov/39858587/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,36980830,Effect of Dietetic Obesity on Testicular Transcriptome in Cynomolgus Monkeys.,2023,10.3390/genes14030557,https://pubmed.ncbi.nlm.nih.gov/36980830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,39922133,Transcriptome and chromatin accessibility landscape of ovarian development at different egg-laying stages in taihe black-bone silky fowls.,2025,10.1016/j.psj.2025.104864,https://pubmed.ncbi.nlm.nih.gov/39922133/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,32059713,"Testicular expression of TDRD1, TDRD5, TDRD9 and TDRD12 in azoospermia.",2020,10.1186/s12881-020-0970-0,https://pubmed.ncbi.nlm.nih.gov/32059713/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,35657999,"The Caenorhabditis elegans TDRD5/7-like protein, LOTR-1, interacts with the helicase ZNFX-1 to balance epigenetic signals in the germline.",2022,10.1371/journal.pgen.1010245,https://pubmed.ncbi.nlm.nih.gov/35657999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,29317670,TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice.,2018,10.1038/s41467-017-02622-w,https://pubmed.ncbi.nlm.nih.gov/29317670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,36895014,Development and validation of an RBP gene signature for prognosis prediction in colorectal cancer based on WGCNA.,2023,10.1186/s41065-023-00274-z,https://pubmed.ncbi.nlm.nih.gov/36895014/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,31432149,Genome‑wide investigation of the clinical implications and molecular mechanism of long noncoding RNA LINC00668 and protein‑coding genes in hepatocellular carcinoma.,2019,10.3892/ijo.2019.4858,https://pubmed.ncbi.nlm.nih.gov/31432149/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,29317647,Investigation of piwi-interacting RNA pathway genes role in idiopathic non-obstructive azoospermia.,2018,10.1038/s41598-017-17518-4,https://pubmed.ncbi.nlm.nih.gov/29317647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,29733347,Disruption of Tdrd5 decouples the stepwise processing of long precursor transcripts during pachytene PIWI-interacting RNA biogenesis.,2018,10.1093/biolre/ioy110,https://pubmed.ncbi.nlm.nih.gov/29733347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,31125834,Evolutionary significance and regulated expression of Tdrd family genes in gynogenetic Japanese flounder (Paralichthys olivaceus).,2019,10.1016/j.cbd.2019.05.003,https://pubmed.ncbi.nlm.nih.gov/31125834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,32141383,Promoter hypermethylation of PIWI/piRNA pathway genes associated with diminished pachytene piRNA production in bovine hybrid male sterility.,2020,10.1080/15592294.2020.1738026,https://pubmed.ncbi.nlm.nih.gov/32141383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,35488327,A prognostic model for oral squamous cell carcinoma using 7 genes related to tumor mutational burden.,2022,10.1186/s12903-022-02193-3,https://pubmed.ncbi.nlm.nih.gov/35488327/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,37469802,Optical Genome Mapping Identifies Novel Recurrent Structural Alterations in Childhood ETV6::RUNX1+ and High Hyperdiploid Acute Lymphoblastic Leukemia.,2023,10.1097/hs9.0000000000000925,https://pubmed.ncbi.nlm.nih.gov/37469802/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,31666004,Weighted single-step GWAS identified candidate genes associated with semen traits in a Duroc boar population.,2019,10.1186/s12864-019-6164-5,https://pubmed.ncbi.nlm.nih.gov/31666004/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,21515969,Tudor domain-containing protein 4 as a potential cancer/testis antigen in liver cancer.,2011,10.1620/tjem.224.41,https://pubmed.ncbi.nlm.nih.gov/21515969/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD5,ENSG00000162782,Unsafe,24586802,"STK31/TDRD8, a germ cell-specific factor, is dispensable for reproduction in mice.",2014,10.1371/journal.pone.0089471,https://pubmed.ncbi.nlm.nih.gov/24586802/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,42922160,"RNA-binding proteins in spermatogenesis: functional mechanisms, clinical potential, and future perspectives. ",2026,10.4103/aja202641,https://pubmed.ncbi.nlm.nih.gov/42922160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,39331689,Loss-of-function variant in TDRD6 cause male infertility with severe oligo-astheno-teratozoospermia in human and mice.,2024,10.1111/jcmm.18580,https://pubmed.ncbi.nlm.nih.gov/39331689/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,39764564,Altered zygotic gene expression caused by sperm with &lt;i&gt;Tdrd6&lt;/i&gt; variants disrupts early embryonic development.,2025,10.1002/mco2.70038,https://pubmed.ncbi.nlm.nih.gov/39764564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,42229831,Exploratory multi‑omics analysis for candidate biomarker identification in Parkinson's disease.,2026,10.1016/j.neuroscience.2026.05.035,https://pubmed.ncbi.nlm.nih.gov/42229831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,38520410,MIWI N-terminal arginines orchestrate generation of functional pachytene piRNAs and spermiogenesis.,2024,10.1093/nar/gkae193,https://pubmed.ncbi.nlm.nih.gov/38520410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,38491008,piRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis.,2024,10.1038/s41467-024-46664-3,https://pubmed.ncbi.nlm.nih.gov/38491008/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,36241908,"VASA protein and gene expression analysis of human non-obstructive azoospermia and normal by immunohistochemistry, immunocytochemistry, and bioinformatics analysis.",2022,10.1038/s41598-022-22137-9,https://pubmed.ncbi.nlm.nih.gov/36241908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,40311511,Comprehensive transcriptome analysis and lncRNA-miRNA-mRNA establishment of schizophrenia based on induced pluripotent stem cells.,2025,10.1016/j.schres.2025.04.027,https://pubmed.ncbi.nlm.nih.gov/40311511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,37073353,Evolutionary dynamics and conserved function of the Tudor domain-containing (TDRD) proteins in teleost fish.,2022,10.1007/s42995-021-00118-7,https://pubmed.ncbi.nlm.nih.gov/37073353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,27149095,Chromatoid Body Protein TDRD6 Supports Long 3' UTR Triggered Nonsense Mediated mRNA Decay.,2016,10.1371/journal.pgen.1005857,https://pubmed.ncbi.nlm.nih.gov/27149095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,34926575,Development and Validation of Ten-RNA Binding Protein Signature Predicts Overall Survival in Osteosarcoma.,2021,10.3389/fmolb.2021.751842,https://pubmed.ncbi.nlm.nih.gov/34926575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,28263986,TDRD6 mediates early steps of spliceosome maturation in primary spermatocytes.,2017,10.1371/journal.pgen.1006660,https://pubmed.ncbi.nlm.nih.gov/28263986/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,31125834,Evolutionary significance and regulated expression of Tdrd family genes in gynogenetic Japanese flounder (Paralichthys olivaceus).,2019,10.1016/j.cbd.2019.05.003,https://pubmed.ncbi.nlm.nih.gov/31125834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,35399512,Integrative Analysis of RNA Expression and Regulatory Networks in Mice Liver Infected by Echinococcus multilocularis.,2022,10.3389/fcell.2022.798551,https://pubmed.ncbi.nlm.nih.gov/35399512/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,32728493,Cellular heterogeneity map of diverse immune and stromal phenotypes within breast tumor microenvironment.,2020,10.7717/peerj.9478,https://pubmed.ncbi.nlm.nih.gov/32728493/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,29551503,TDRD6 is associated with oligoasthenoteratozoospermia by sequencing the patient from a consanguineous family.,2018,10.1016/j.gene.2018.03.040,https://pubmed.ncbi.nlm.nih.gov/29551503/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,28444146,Nonsense in the testis: multiple roles for nonsense-mediated decay revealed in male reproduction.,2017,10.1093/biolre/iox033,https://pubmed.ncbi.nlm.nih.gov/28444146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,36185367,The chromosome-scale genome of the raccoon dog: Insights into its evolutionary characteristics.,2022,10.1016/j.isci.2022.105117,https://pubmed.ncbi.nlm.nih.gov/36185367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,35116519,Construction of a prognostic risk model of colorectal adenocarcinoma through integrated analysis of RNA-binding proteins.,2021,10.21037/tcr-21-40,https://pubmed.ncbi.nlm.nih.gov/35116519/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,33711033,Integrated analysis of RNA-binding proteins in thyroid cancer.,2021,10.1371/journal.pone.0247836,https://pubmed.ncbi.nlm.nih.gov/33711033/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,31472347,Arsenic influences spermatogenesis by disorganizing the elongation of spermatids in adult male mice.,2020,10.1016/j.chemosphere.2019.124650,https://pubmed.ncbi.nlm.nih.gov/31472347/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,31682594,Network-based analysis of prostate cancer cell lines reveals novel marker gene candidates associated with radioresistance and patient relapse.,2019,10.1371/journal.pcbi.1007460,https://pubmed.ncbi.nlm.nih.gov/31682594/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRD6,ENSG00000180113,Unsafe,23721730,"Titanium dioxide nanoparticle-induced testicular damage, spermatogenesis suppression, and gene expression alterations in male mice.",2013,10.1016/j.jhazmat.2013.04.046,https://pubmed.ncbi.nlm.nih.gov/23721730/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,42564021,Post-transcriptional regulation via alternative polyadenylation and piRNA shapes macrophage responses in psoriasis.,2026,10.3389/fimmu.2026.1760348,https://pubmed.ncbi.nlm.nih.gov/42564021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,42625859,"Dysregulation of piRNA biogenesis-associated proteins in cancer: mechanisms, evidence, and translational constraints.",2026,10.3389/fmolb.2026.1906635,https://pubmed.ncbi.nlm.nih.gov/42625859/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,41043513,Proteomic Analysis of Human Topoisomerases Reveals Their Distinct and Diverse Cellular Functions.,2025,10.1016/j.mcpro.2025.101082,https://pubmed.ncbi.nlm.nih.gov/41043513/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,41250910,Decoding nuclear-encoded mitochondrial genes in major depressive disorder: A multi-omics perspective.,2025,10.1017/s0033291725102559,https://pubmed.ncbi.nlm.nih.gov/41250910/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,41059337,Cracking the code: how piRNA pathway shapes spermatogenesis and combats male infertility.,2025,10.3389/fcell.2025.1657744,https://pubmed.ncbi.nlm.nih.gov/41059337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,40564099,Integrative Analysis of Plasma Proteomics and Transcriptomics Reveals Potential Therapeutic Targets for Psoriasis.,2025,10.3390/biomedicines13061380,https://pubmed.ncbi.nlm.nih.gov/40564099/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,41023308,PIWI proteins tether the piRNA biogenesis machinery to mitochondria during mammalian spermatogenesis.,2025,10.1038/s44318-025-00579-x,https://pubmed.ncbi.nlm.nih.gov/41023308/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,39934434,"A novel defined risk signature of ferroptosis-related lncRNAs for predicting prognosis, immune infiltration, and chemotherapy response in multiple myeloma.",2025,10.1007/s12672-025-01947-z,https://pubmed.ncbi.nlm.nih.gov/39934434/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,38008726,LncRNA TDRKH-AS1 promotes breast cancer progression via the miR-134-5p/CREB1 axis.,2023,10.1186/s12967-023-04640-3,https://pubmed.ncbi.nlm.nih.gov/38008726/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,39444988,Investigating the role of prognostic mitophagy-related genes in non-small cell cancer pathogenesis via multiomics and network-based approach.,2024,10.1007/s13205-024-04127-y,https://pubmed.ncbi.nlm.nih.gov/39444988/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,38956960,Whole genome sequencing identifies a homozygous splicing variant in TDRKH segregating with non-obstructive azoospermia in an Iranian family.,2024,10.1111/cge.14584,https://pubmed.ncbi.nlm.nih.gov/38956960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,42682829,Proteome-wide Mendelian randomisation of lung function to identify potential therapeutic targets for respiratory disease.,2026,10.1183/23120541.00828-2025,https://pubmed.ncbi.nlm.nih.gov/42682829/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,38520410,MIWI N-terminal arginines orchestrate generation of functional pachytene piRNAs and spermiogenesis.,2024,10.1093/nar/gkae193,https://pubmed.ncbi.nlm.nih.gov/38520410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,38491008,piRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis.,2024,10.1038/s41467-024-46664-3,https://pubmed.ncbi.nlm.nih.gov/38491008/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,40104741,Construction and validation of a prognostic model of lncRNAs associated with RNA methylation in lung adenocarcinoma.,2025,10.21037/tcr-24-1085,https://pubmed.ncbi.nlm.nih.gov/40104741/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,37488572,Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia.,2023,10.1186/s12967-023-04346-6,https://pubmed.ncbi.nlm.nih.gov/37488572/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,36777835,Three RNA-binding protein signature as a novel biomarker to predict endometrial cancer prognosis.,2023,,https://pubmed.ncbi.nlm.nih.gov/36777835/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,37956204,MIWI N-terminal RG motif promotes efficient pachytene piRNA production and spermatogenesis independent of LINE1 transposon silencing.,2023,10.1371/journal.pgen.1011031,https://pubmed.ncbi.nlm.nih.gov/37956204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,40187354,Integration of biobank-scale genetics and plasma proteomics reveals evidence for causal processes in asthma risk and heterogeneity.,2025,10.1016/j.xgen.2025.100840,https://pubmed.ncbi.nlm.nih.gov/40187354/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,40750267,Loss of Different Domains of TDRD12 Leads to Distinct Male Infertility-Related Phenotypes.,2026,10.1111/cge.70034,https://pubmed.ncbi.nlm.nih.gov/40750267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,38855504,Disulfidptosis‑related lncRNA prognosis model to predict survival therapeutic response prediction in lung adenocarcinoma.,2024,10.3892/ol.2024.14476,https://pubmed.ncbi.nlm.nih.gov/38855504/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,39778021,Assessing the Causal Effect of Circulating Protein-To-Protein Ratio on the Risk of Morbidity of Hepatocellular Carcinoma.,2025,10.1002/cam4.70570,https://pubmed.ncbi.nlm.nih.gov/39778021/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,32670860,Long Non-coding RNA TDRKH-AS1 Promotes Colorectal Cancer Cell Proliferation and Invasion Through the β-Catenin Activated Wnt Signaling Pathway.,2020,10.3389/fonc.2020.00639,https://pubmed.ncbi.nlm.nih.gov/32670860/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,35193591,A novel qualitative signature based on lncRNA pairs for prognosis prediction in hepatocellular carcinoma.,2022,10.1186/s12935-022-02507-z,https://pubmed.ncbi.nlm.nih.gov/35193591/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,34347949,"Variant PNLDC1, Defective piRNA Processing, and Azoospermia.",2021,10.1056/nejmoa2028973,https://pubmed.ncbi.nlm.nih.gov/34347949/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,24586802,"STK31/TDRD8, a germ cell-specific factor, is dispensable for reproduction in mice.",2014,10.1371/journal.pone.0089471,https://pubmed.ncbi.nlm.nih.gov/24586802/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TDRKH,ENSG00000182134,Unsafe,26474455,Genetic polymorphisms associated with increased risk of developing chronic myelogenous leukemia.,2015,10.18632/oncotarget.5915,https://pubmed.ncbi.nlm.nih.gov/26474455/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,40583560,A novel splicing variant in TECTA associated with prelingual autosomal dominant nonsyndromic hearing loss via dominant-negative effect.,2025,10.1093/hmg/ddaf109,https://pubmed.ncbi.nlm.nih.gov/40583560/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,42702881,TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non-Syndromic Hearing Loss.,2026,10.1002/advs.77543,https://pubmed.ncbi.nlm.nih.gov/42702881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,41817103,Divergence of Visual Morphology and Opsin Expression in an African Cichlid Linked With Turbidity.,2026,10.1111/mec.70278,https://pubmed.ncbi.nlm.nih.gov/41817103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,39437584,Critical role of hepsin/TMPRSS1 in hearing and tectorial membrane morphogenesis: Insights from transgenic mouse models.,2024,10.1016/j.heares.2024.109134,https://pubmed.ncbi.nlm.nih.gov/39437584/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,40901670,"Tectorial membrane: structure, function, and its implications for hearing loss.",2025,10.3389/fneur.2025.1630549,https://pubmed.ncbi.nlm.nih.gov/40901670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,41476317,Parallel Morphological and Functional Development in the Xenopus Retinotectal System.,2026,10.1002/dneu.70007,https://pubmed.ncbi.nlm.nih.gov/41476317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,39657673,Microvilli control the morphogenesis of the tectorial membrane extracellular matrix.,2025,10.1016/j.devcel.2024.11.011,https://pubmed.ncbi.nlm.nih.gov/39657673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,38676628,Reevaluating the splice-altering variant in TECTA as a cause of nonsyndromic hearing loss DFNA8/12 by functional analysis of RNA.,2024,10.1093/hmg/ddae071,https://pubmed.ncbi.nlm.nih.gov/38676628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,39857269,Exploring Brain Size Asymmetry and Its Relationship with Predation Risk Among Chinese Anurans.,2025,10.3390/biology14010038,https://pubmed.ncbi.nlm.nih.gov/39857269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,38474154,Validation of RNA Extraction Methods and Suitable Reference Genes for Gene Expression Studies in Developing Fetal Human Inner Ear Tissue.,2024,10.3390/ijms25052907,https://pubmed.ncbi.nlm.nih.gov/38474154/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,38367039,Characterization of pathological changes in the olfactory system of mice exposed to methylmercury.,2024,10.1007/s00204-024-03682-w,https://pubmed.ncbi.nlm.nih.gov/38367039/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,38997160,Synaptic Connectivity and Electrophysiological Properties of the Nucleus of the Lateral Olfactory Tract.,2024,10.1523/jneurosci.2420-23.2024,https://pubmed.ncbi.nlm.nih.gov/38997160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,39012795,Specific and comprehensive genetic targeting reveals brain-wide distribution and synaptic input patterns of GABAergic axo-axonic interneurons.,2024,10.7554/elife.93481,https://pubmed.ncbi.nlm.nih.gov/39012795/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,37399346,Lateral semicircular canal dilatation in a patient with congenital hearing loss due to α-tectorin mutation: microanatomical considerations.,2023,10.1136/bcr-2022-254068,https://pubmed.ncbi.nlm.nih.gov/37399346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,37282449,Differentiation and functional connectivity of fetal tectal transplants.,2023,10.4103/1673-5374.371348,https://pubmed.ncbi.nlm.nih.gov/37282449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,39974400,Establishment and validation of predictive models by mutational and transcriptional factors for the prognosis of stage IV colorectal cancer patients with liver metastasis who undergo palliative surgery on primary tumors.,2025,10.21037/tcr-24-1183,https://pubmed.ncbi.nlm.nih.gov/39974400/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,38490646,Intracranial self-stimulation reverses impaired spatial learning and regulates serum microRNA levels in a streptozotocin-induced rat model of Alzheimer disease.,2024,10.1503/jpn.230066,https://pubmed.ncbi.nlm.nih.gov/38490646/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,38373826,"The Effects of Rearing Environment on Organization of the Olfactory System and Brain of Juvenile Sockeye Salmon, Oncorhynchus nerka.",2024,10.1093/icb/icae002,https://pubmed.ncbi.nlm.nih.gov/38373826/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,40656120,"A novel, non-opioid, selective orexin-1 receptor antagonist for the treatment of substance use disorders.",2024,10.1016/j.nsa.2024.104053,https://pubmed.ncbi.nlm.nih.gov/40656120/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,39332802,Salinization and low-dose levels of pesticides alter brain shape of larval amphibians.,2024,10.1016/j.envpol.2024.125027,https://pubmed.ncbi.nlm.nih.gov/39332802/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,36565421,Genetic advances in Meniere Disease.,2023,10.1007/s11033-022-08149-8,https://pubmed.ncbi.nlm.nih.gov/36565421/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,32749216,Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior.,2020,10.7554/elife.57268,https://pubmed.ncbi.nlm.nih.gov/32749216/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,34322810,Bioinformatic analyses suggest augmented interleukin-17 signaling as the mechanism of COVID-19-associated herpes zoster.,2021,10.1007/s11356-021-15567-x,https://pubmed.ncbi.nlm.nih.gov/34322810/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,36682503,Global brain c-Fos profiling reveals major functional brain networks rearrangements after alcohol reexposure.,2023,10.1016/j.nbd.2023.106006,https://pubmed.ncbi.nlm.nih.gov/36682503/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,37371710,Autosomal Dominant Non-Syndromic Hearing Loss (DFNA): A Comprehensive Narrative Review.,2023,10.3390/biomedicines11061616,https://pubmed.ncbi.nlm.nih.gov/37371710/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,25549536,RWDD3 and TECTA variants not linked to paclitaxel induced peripheral neuropathy in North American trial Alliance N08C1.,2015,10.3109/0284186x.2014.985388,https://pubmed.ncbi.nlm.nih.gov/25549536/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,29371927,Independent replication of polymorphisms predicting toxicity in breast cancer patients randomized between dose-dense and docetaxel-containing adjuvant chemotherapy.,2017,10.18632/oncotarget.22697,https://pubmed.ncbi.nlm.nih.gov/29371927/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,35453615,Increases of Phosphorylated Tau (Ser202/Thr205) in the Olfactory Regions Are Associated with Impaired EEG and Olfactory Behavior in Traumatic Brain Injury Mice.,2022,10.3390/biomedicines10040865,https://pubmed.ncbi.nlm.nih.gov/35453615/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,34048796,Early Developmental Exposure to Fluoxetine and Citalopram Results in Different Neurodevelopmental Outcomes.,2021,10.1016/j.neuroscience.2021.05.023,https://pubmed.ncbi.nlm.nih.gov/34048796/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,35551471,"SCN1A overexpression, associated with a genomic region marked by a risk variant for a common epilepsy, raises seizure susceptibility.",2022,10.1007/s00401-022-02429-0,https://pubmed.ncbi.nlm.nih.gov/35551471/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,36365050,"First Record of the Rare Species Aeromonas lusitana from Rainbow Trout (Oncorhynchus mykiss, Walbaum): Comparative Analysis with the Existing Strains.",2022,10.3390/pathogens11111299,https://pubmed.ncbi.nlm.nih.gov/36365050/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,31609204,Novel long-range inhibitory nNOS-expressing hippocampal cells.,2019,10.7554/elife.46816,https://pubmed.ncbi.nlm.nih.gov/31609204/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,25758224,Otolith tethering in the zebrafish otic vesicle requires Otogelin and α-Tectorin.,2015,10.1242/dev.116632,https://pubmed.ncbi.nlm.nih.gov/25758224/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,33929649,Feeding design in free-living mesostigmatid chelicerae (Acari: Anactinotrichida).,2021,10.1007/s10493-021-00612-8,https://pubmed.ncbi.nlm.nih.gov/33929649/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TECTA,ENSG00000109927,Unsafe,29667327,Novel West syndrome candidate genes in a Chinese cohort.,2018,10.1111/cns.12860,https://pubmed.ncbi.nlm.nih.gov/29667327/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEDC2,ENSG00000162062,Unsafe,41352505,Tubulin epsilon and delta complex 2 enhances malignancy in non-small cell lung cancer by activating the hedgehog signaling pathway to promote tumor cell stemness.,2026,10.1016/j.ijbiomac.2025.149503,https://pubmed.ncbi.nlm.nih.gov/41352505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEDC2,ENSG00000162062,Unsafe,42196266,Machine Learning-Based Identification of Biomarkers for Early-Stage Non-Small Cell Lung Cancer Through Gene Expression Analysis.,2026,10.3390/ijms27104282,https://pubmed.ncbi.nlm.nih.gov/42196266/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEDC2,ENSG00000162062,Unsafe,39979680,Biallelic TEDC1 variants cause a new syndrome with severe growth impairment and endocrine complications.,2025,10.1038/s41431-025-01802-3,https://pubmed.ncbi.nlm.nih.gov/39979680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEDC2,ENSG00000162062,Unsafe,37867019,TEDC2 plays an oncogenic role and serves as a therapeutic target of hepatocellular carcinoma.,2024,10.1016/j.dld.2023.09.025,https://pubmed.ncbi.nlm.nih.gov/37867019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEDC2,ENSG00000162062,Unsafe,39553728,Comprehensive analysis of transcriptomics and radiomics revealed the potential of TEDC2 as a diagnostic marker for lung adenocarcinoma.,2024,10.7717/peerj.18310,https://pubmed.ncbi.nlm.nih.gov/39553728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEDC2,ENSG00000162062,Unsafe,38239349,A pan-cancer analysis of the prognostic implication and oncogenic role of tubulin epsilon and delta complex 2 (TEDC2) in human tumors.,2023,10.3389/fimmu.2023.1272108,https://pubmed.ncbi.nlm.nih.gov/38239349/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEDC2,ENSG00000162062,Unsafe,37350390,Identification of potential prognostic markers for lung adenocarcinoma using comprehensive analysis.,2023,10.3892/mmr.2023.13036,https://pubmed.ncbi.nlm.nih.gov/37350390/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEDC2,ENSG00000162062,Unsafe,40067174,A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture.,2025,10.7554/elife.98704,https://pubmed.ncbi.nlm.nih.gov/40067174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEDC2,ENSG00000162062,Unsafe,36973475,TEDC2 correlated with prognosis and immune microenvironment in lung adenocarcinoma.,2023,10.1038/s41598-023-32238-8,https://pubmed.ncbi.nlm.nih.gov/36973475/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEDC2,ENSG00000162062,Unsafe,35087752,Identification of Novel Prognostic Markers Associated With Laryngeal Squamous Cell Carcinoma Using Comprehensive Analysis.,2021,10.3389/fonc.2021.779153,https://pubmed.ncbi.nlm.nih.gov/35087752/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEDC2,ENSG00000162062,Unsafe,34956967,Key Candidate Prognostic Biomarkers Correlated with Immune Infiltration in Hepatocellular Carcinoma.,2021,10.2147/jhc.s337067,https://pubmed.ncbi.nlm.nih.gov/34956967/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEDC2,ENSG00000162062,Unsafe,33993705,Genome-wide associations between alcohol consumption and blood DNA methylation: evidence from twin study.,2021,10.2217/epi-2021-0039,https://pubmed.ncbi.nlm.nih.gov/33993705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEDC2,ENSG00000162062,Unsafe,26356813,"Triple-layer dissection of the lung adenocarcinoma transcriptome: regulation at the gene, transcript, and exon levels.",2015,10.18632/oncotarget.4810,https://pubmed.ncbi.nlm.nih.gov/26356813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEDC2,ENSG00000162062,Unsafe,26019538,Whole genome methylation analyses of schizophrenia patients before and after treatment.,2014,10.1080/13102818.2014.933501,https://pubmed.ncbi.nlm.nih.gov/26019538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEDC2,ENSG00000162062,Unsafe,26026093,Microarray Gene-expression Profiling Analysis Comparing PCNSL and Non-CNS Diffuse Large B-Cell Lymphoma.,2015,,https://pubmed.ncbi.nlm.nih.gov/26026093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,41194443,CRISPR/Cas9-mediated genome editing identifies six testis-expressed genes individually dispensable for overt male fecundity in mice.,2026,10.7555/jbr.39.20250247,https://pubmed.ncbi.nlm.nih.gov/41194443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,40243732,Tekt3 Safeguards Proper Functions and Morphology of Neuromast Hair Bundles.,2025,10.3390/ijms26073115,https://pubmed.ncbi.nlm.nih.gov/40243732/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,38448737,"Tektin bundle interacting protein, TEKTIP1, functions to stabilize the tektin bundle and axoneme in mouse sperm flagella.",2024,10.1007/s00018-023-05081-3,https://pubmed.ncbi.nlm.nih.gov/38448737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,42416903,Alterations in the protein lactylation landscape of sperm from patients with varicocele-associated asthenozoospermia.,2026,10.3389/fendo.2026.1791920,https://pubmed.ncbi.nlm.nih.gov/42416903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,42615880,Key regulatory genes and pathways in spermatogenesis identified by transcriptome profiling of the hypothalamic-pituitary-gonadal axis during sexual maturation in Wenchang roosters.,2026,10.1080/00071668.2026.2702458,https://pubmed.ncbi.nlm.nih.gov/42615880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,40649876,Age-Associated Proteomic Changes in Human Spermatozoa.,2025,10.3390/ijms26136099,https://pubmed.ncbi.nlm.nih.gov/40649876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,42800358,Time-resolved transcriptomics reveals sex-specific programs of gametogenesis and post-spawning gonadal remodeling in the sea cucumber Apostichopus japonicus.,2026,10.1016/j.cbd.2026.102025,https://pubmed.ncbi.nlm.nih.gov/42800358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,39677330,Identification of differentially expressed genes in human testis biopsies with defective spermatogenesis.,2024,10.1002/rmb2.12616,https://pubmed.ncbi.nlm.nih.gov/39677330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,36708031,Bi-allelic human TEKT3 mutations cause male infertility with oligoasthenoteratozoospermia owing to acrosomal hypoplasia and reduced progressive motility.,2023,10.1093/hmg/ddad013,https://pubmed.ncbi.nlm.nih.gov/36708031/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,42036177,Prenatal phenotypes and pregnancy outcomes of fetuses with 17p12 microdeletions and microduplications.,2026,10.1016/j.tjog.2025.11.023,https://pubmed.ncbi.nlm.nih.gov/42036177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,38799722,Sperm long non-coding RNAs as markers for ram fertility.,2024,10.3389/fvets.2024.1337939,https://pubmed.ncbi.nlm.nih.gov/38799722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,39333243,"Adipose gene expression profiles in Northern Finncattle, Mirandesa cattle, Yakutian cattle and commercial Holstein cattle.",2024,10.1038/s41598-024-73023-5,https://pubmed.ncbi.nlm.nih.gov/39333243/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,39856550,Whole-genome resequencing landscape of adaptive evolution in Relict gull (Larus relictus).,2025,10.1186/s12864-025-11257-x,https://pubmed.ncbi.nlm.nih.gov/39856550/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,35804605,Comparative Proteomic Analyses of Poorly Motile Swamp Buffalo Spermatozoa Reveal Low Energy Metabolism and Deficiencies in Motility-Related Proteins.,2022,10.3390/ani12131706,https://pubmed.ncbi.nlm.nih.gov/35804605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,32251302,Transcriptomic analysis of female and male gonads in juvenile snakeskin gourami (Trichopodus pectoralis).,2020,10.1038/s41598-020-61738-0,https://pubmed.ncbi.nlm.nih.gov/32251302/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,36766254,Identification of New Candidate Genes Related to Semen Traits in Duroc Pigs through Weighted Single-Step GWAS.,2023,10.3390/ani13030365,https://pubmed.ncbi.nlm.nih.gov/36766254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,25999357,Spermatozoa protein alterations in infertile men with bilateral varicocele.,2016,10.4103/1008-682x.153848,https://pubmed.ncbi.nlm.nih.gov/25999357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,35595453,A false-positive result at non-invasive prenatal testing due to maternal 17p12 microduplication.,2022,10.1016/j.tjog.2022.03.037,https://pubmed.ncbi.nlm.nih.gov/35595453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,26268136,Identification and characterization of a bovine sperm acrosomal matrix protein and its mechanism of interaction with acrosomal hydrolases.,2015,10.1007/s11010-015-2534-8,https://pubmed.ncbi.nlm.nih.gov/26268136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,31479777,Identifying candidate genes associated with sperm morphology abnormalities using weighted single-step GWAS in a Duroc boar population.,2020,10.1016/j.theriogenology.2019.08.031,https://pubmed.ncbi.nlm.nih.gov/31479777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT3,ENSG00000125409,Unsafe,36191189,SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.,2022,10.1073/pnas.2207605119,https://pubmed.ncbi.nlm.nih.gov/36191189/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT4,ENSG00000163060,Unsafe,42630843,Cytoskeletal dynamics in breast cancer: mechanistic insights and therapeutic opportunities.,2026,10.1016/j.jncc.2025.09.006,https://pubmed.ncbi.nlm.nih.gov/42630843/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT4,ENSG00000163060,Unsafe,35547812,"Hdh-Tektin-4 Regulates Motility of Fresh and Cryopreserved Sperm in Pacific Abalone, Haliotis discus hannai.",2022,10.3389/fcell.2022.870743,https://pubmed.ncbi.nlm.nih.gov/35547812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT4,ENSG00000163060,Unsafe,40594066,Pan-Cancer Exome-wide analysis of germline mutational patterns and pathways.,2025,10.1038/s41598-025-05296-3,https://pubmed.ncbi.nlm.nih.gov/40594066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT4,ENSG00000163060,Unsafe,38137330,Study on Potential Differentially Expressed Genes in Idiopathic Pulmonary Fibrosis by Bioinformatics and Next-Generation Sequencing Data Analysis.,2023,10.3390/biomedicines11123109,https://pubmed.ncbi.nlm.nih.gov/38137330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT4,ENSG00000163060,Unsafe,36936432,Case report: Novel TBX5-related pathogenic mechanism of Holt-Oram syndrome.,2023,10.3389/fgene.2023.1063202,https://pubmed.ncbi.nlm.nih.gov/36936432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT4,ENSG00000163060,Unsafe,35447134,Cathepsin F genetic mutation is associated with familial papillary thyroid cancer.,2022,10.1016/j.amjms.2022.03.017,https://pubmed.ncbi.nlm.nih.gov/35447134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT4,ENSG00000163060,Unsafe,36714547,High-throughput proteomic characterization of seminal plasma from bulls with contrasting semen quality.,2023,10.1007/s13205-023-03474-6,https://pubmed.ncbi.nlm.nih.gov/36714547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT4,ENSG00000163060,Unsafe,32677196,A prospective multicenter phase II study on the efficacy and safety of dasatinib in the treatment of metastatic gastrointestinal stromal tumors failed by imatinib and sunitinib and analysis of NGS in peripheral blood.,2020,10.1002/cam4.3319,https://pubmed.ncbi.nlm.nih.gov/32677196/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT4,ENSG00000163060,Unsafe,25761592,Comparative analysis of testis transcriptomes from triploid and fertile diploid cyprinid fish.,2015,10.1095/biolreprod.114.125609,https://pubmed.ncbi.nlm.nih.gov/25761592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT4,ENSG00000163060,Unsafe,24823476,Enriched variations in TEKT4 and breast cancer resistance to paclitaxel.,2014,10.1038/ncomms4802,https://pubmed.ncbi.nlm.nih.gov/24823476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT4,ENSG00000163060,Unsafe,18951373,Tektin 3 is required for progressive sperm motility in mice.,2009,10.1002/mrd.20957,https://pubmed.ncbi.nlm.nih.gov/18951373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT4,ENSG00000163060,Unsafe,22774605,[Expression of TEKT4 protein decreases in the ejaculated spermatozoa of idiopathic asthenozoospermic men].,2012,,https://pubmed.ncbi.nlm.nih.gov/22774605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT4,ENSG00000163060,Unsafe,17244819,Absence of tektin 4 causes asthenozoospermia and subfertility in male mice.,2007,10.1096/fj.06-7035com,https://pubmed.ncbi.nlm.nih.gov/17244819/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT4,ENSG00000163060,Unsafe,27871913,What can time-frequency and phase coherence measures tell us about the genetic basis of P3 amplitude?,2017,10.1016/j.ijpsycho.2016.11.008,https://pubmed.ncbi.nlm.nih.gov/27871913/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT4,ENSG00000163060,Unsafe,32975708,Randomized phase II clinical trial and biomarker analysis of paclitaxel plus epirubicin versus vinorelbine plus epirubicin as neoadjuvant chemotherapy in locally advanced HER2-negative breast cancer with TEKT4 variations.,2021,10.1007/s10549-020-05940-8,https://pubmed.ncbi.nlm.nih.gov/32975708/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKT4,ENSG00000163060,Unsafe,36191189,SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.,2022,10.1073/pnas.2207605119,https://pubmed.ncbi.nlm.nih.gov/36191189/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKTL1,ENSG00000160994,Unsafe,41316927,Microtubule Inner Protein CFAP77 Contributes to Sperm Motility and Male Fertility in Mice.,2026,10.1111/andr.70152,https://pubmed.ncbi.nlm.nih.gov/41316927/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKTL1,ENSG00000160994,Unsafe,41118442,The core outer junction protein CFAP77 connects A- and B-tubules within doublet microtubules of cilia and flagella.,2025,10.1371/journal.pbio.3003442,https://pubmed.ncbi.nlm.nih.gov/41118442/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKTL1,ENSG00000160994,Unsafe,38835510,Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility.,2024,10.3389/fcell.2024.1411162,https://pubmed.ncbi.nlm.nih.gov/38835510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKTL1,ENSG00000160994,Unsafe,38704377,Mutation characteristics and molecular evolution of ovarian metastasis from gastric cancer and potential biomarkers for paclitaxel treatment.,2024,10.1038/s41467-024-48144-0,https://pubmed.ncbi.nlm.nih.gov/38704377/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEKTL1,ENSG00000160994,Unsafe,37865089,De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking.,2023,10.1016/j.cell.2023.09.017,https://pubmed.ncbi.nlm.nih.gov/37865089/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,41276573,"TESMIN promotes lung adenocarcinoma proliferation, migration and invasion via PI3K/AKT/mTOR signaling.",2025,10.1038/s41598-025-28798-6,https://pubmed.ncbi.nlm.nih.gov/41276573/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,39229988,TESMIN is a Prognostic Biomarker Associated with Immunosuppression and Activated Cell Cycle in Lung Adenocarcinoma.,2025,10.2174/0109298673315434240826100918,https://pubmed.ncbi.nlm.nih.gov/39229988/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,38283987,Clinical Significance and Functional Insights of Tesmin in Hepatocellular Carcinoma.,2024,10.1155/2024/3058875,https://pubmed.ncbi.nlm.nih.gov/38283987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,39831256,Comprehensive bioinformatics analysis of prognosis and immunotherapy in lung adenocarcinoma.,2024,10.21037/jtd-24-1530,https://pubmed.ncbi.nlm.nih.gov/39831256/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,41301891,GBA1 Gene-Associated Transcriptomic Signatures Reveal Risk Genes in Parkinson's Disease.,2025,10.3390/biomedicines13112799,https://pubmed.ncbi.nlm.nih.gov/41301891/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,33281959,Role of tesmin expression in non-small cell lung cancer.,2021,10.3892/ol.2020.12309,https://pubmed.ncbi.nlm.nih.gov/33281959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,36564444,Proximity-dependent biotin labeling in testicular germ cells identified TESMIN-associated proteins.,2022,10.1038/s41598-022-26501-7,https://pubmed.ncbi.nlm.nih.gov/36564444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,31916570,"Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice†.",2020,10.1093/biolre/ioaa002,https://pubmed.ncbi.nlm.nih.gov/31916570/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,31059101,Expression of tesmin (MTL5) in non‑small cell lung cancer: A preliminary study.,2019,10.3892/or.2019.7145,https://pubmed.ncbi.nlm.nih.gov/31059101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,35249447,Metallothionein-like 5 expression is correlated with poor prognosis and promotes proliferation of cervical squamous cell carcinoma.,2022,10.1080/21655979.2022.2036901,https://pubmed.ncbi.nlm.nih.gov/35249447/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,39915770,Preoperative liquid biopsy transcriptomic panel for risk assessment of lymph node metastasis in T1 gastric cancer.,2025,10.1186/s13046-025-03305-x,https://pubmed.ncbi.nlm.nih.gov/39915770/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,34388164,Nuclear translocation of MTL5 from cytoplasm requires its direct interaction with LIN9 and is essential for male meiosis and fertility.,2021,10.1371/journal.pgen.1009753,https://pubmed.ncbi.nlm.nih.gov/34388164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,40522509,Genome-wide identification and functional analysis of TCX gene family and the critical role of GhTCX17 in response to drought and salt stress in cotton.,2025,10.1007/s10142-025-01632-y,https://pubmed.ncbi.nlm.nih.gov/40522509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,33783608,Cellular and subcellular localization of endogenous phospholipase D6 in seminiferous tubules of mouse testes.,2021,10.1007/s00441-021-03442-7,https://pubmed.ncbi.nlm.nih.gov/33783608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,33257503,Prediction and Validation of Mouse Meiosis-Essential Genes Based on Spermatogenesis Proteome Dynamics.,2021,10.1074/mcp.ra120.002081,https://pubmed.ncbi.nlm.nih.gov/33257503/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,34404837,The ABCC4 gene is associated with pyometra in golden retriever dogs.,2021,10.1038/s41598-021-95936-1,https://pubmed.ncbi.nlm.nih.gov/34404837/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,34545296,Oxidative Stress Genes in Diabetes Mellitus Type 2: Association with Diabetic Kidney Disease.,2021,10.1155/2021/2531062,https://pubmed.ncbi.nlm.nih.gov/34545296/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,31514295,Involvement of Dual Strands of miR-143 (miR-143-5p and miR-143-3p) and Their Target Oncogenes in the Molecular Pathogenesis of Lung Adenocarcinoma.,2019,10.3390/ijms20184482,https://pubmed.ncbi.nlm.nih.gov/31514295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,28369098,Functional relevance for associations between osteoporosis and genetic variants.,2017,10.1371/journal.pone.0174808,https://pubmed.ncbi.nlm.nih.gov/28369098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,26296075,Decreased spermatogenesis led to alterations of testis-specific gene expression in male mice following nano-TiO2 exposure.,2015,10.1016/j.jhazmat.2015.08.010,https://pubmed.ncbi.nlm.nih.gov/26296075/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,31071517,Diagnostic significance of metallothionein members in recognizing cadmium exposure in various organs under low-dose exposure.,2019,10.1016/j.chemosphere.2019.04.192,https://pubmed.ncbi.nlm.nih.gov/31071517/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,29725345,A Genome-Wide Linkage Study for Chronic Obstructive Pulmonary Disease in a Dutch Genetic Isolate Identifies Novel Rare Candidate Variants.,2018,10.3389/fgene.2018.00133,https://pubmed.ncbi.nlm.nih.gov/29725345/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,24565835,"Zinc protects cyclophosphamide-induced testicular damage in rat: involvement of metallothionein, tesmin and Nrf2.",2014,10.1016/j.bbrc.2014.02.055,https://pubmed.ncbi.nlm.nih.gov/24565835/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,24055800,"Tributyltin chloride induced testicular toxicity by JNK and p38 activation, redox imbalance and cell death in sertoli-germ cell co-culture.",2013,10.1016/j.tox.2013.09.003,https://pubmed.ncbi.nlm.nih.gov/24055800/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,21664405,Interplay of early biochemical manifestations by cadmium insult in sertoli-germ coculture: an in vitro study.,2011,10.1016/j.tox.2011.05.013,https://pubmed.ncbi.nlm.nih.gov/21664405/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,25371445,Association of prostate cancer risk variants with gene expression in normal and tumor tissue.,2015,10.1158/1055-9965.epi-14-0694-t,https://pubmed.ncbi.nlm.nih.gov/25371445/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TESMIN,ENSG00000132749,Unsafe,27142620,Ostreococcus tauri is a new model green alga for studying iron metabolism in eukaryotic phytoplankton.,2016,10.1186/s12864-016-2666-6,https://pubmed.ncbi.nlm.nih.gov/27142620/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42804960,TET1-mediated demethylation of UGT1A1 suppresses neuronal ferroptosis and brain injury in bilirubin encephalopathy.,2026,10.1016/j.tice.2026.103980,https://pubmed.ncbi.nlm.nih.gov/42804960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42637820,DREAMS illuminates spatial DNA and RNA modification landscapes.,2026,10.1038/s41556-026-02038-z,https://pubmed.ncbi.nlm.nih.gov/42637820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42754661,YAP1 induces hepatocellular carcinoma via DNA demethylation rather than by canonical driver gene mutations.,2026,10.1038/s42003-026-10882-w,https://pubmed.ncbi.nlm.nih.gov/42754661/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,41896302,TET1 deficiency amplifies macrophage inflammatory signaling associated with Crohn's disease.,2026,10.1007/s00011-026-02228-3,https://pubmed.ncbi.nlm.nih.gov/41896302/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42665721,TET1-mediated DNA demethylation and transcription activation of MRPS17 induces lung adenocarcinoma through PI3K-AKT-mTOR pathway.,2026,10.1007/s10735-026-10862-8,https://pubmed.ncbi.nlm.nih.gov/42665721/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42091342,TET1 downregulation in the dorsal root ganglion and spinal cord is required for short-term sleep disturbance to delay surgical pain recovery.,2026,10.1016/j.bja.2026.02.025,https://pubmed.ncbi.nlm.nih.gov/42091342/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42393935,Exposure to Dim Light at Night Impairs Photoperiodic and Metabolic Gene Expression in Syrian Hamsters (Mesocricetus auratus).,2026,10.1002/jez.70113,https://pubmed.ncbi.nlm.nih.gov/42393935/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42851704,TET1 loss promotes malignant phenotypes in HeLa cells and is associated with altered PTEN-PI3K/AKT/mTOR signaling.,2026,10.3389/fonc.2026.1963427,https://pubmed.ncbi.nlm.nih.gov/42851704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42129486,Pyruvate carboxylase promotes SREBP1a-mediated lipid synthesis in epithelial ovarian cancer.,2026,10.1038/s42003-026-10253-5,https://pubmed.ncbi.nlm.nih.gov/42129486/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42725138,Multi-functional bionic nanoparticles for precise neuronal targeting and synergistic therapy in Alzheimer's disease.,2026,10.1016/j.mtbio.2026.103617,https://pubmed.ncbi.nlm.nih.gov/42725138/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42132410,Prenatal alcohol exposure-mediated Tet1 upregulation promotes DNA demethylation and elevated transcription at the miR-150 promoter.,2026,10.1152/ajpcell.00140.2026,https://pubmed.ncbi.nlm.nih.gov/42132410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42435767,TET1 Inhibition Promotes Therapeutic Sensitivity in TP53-Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology.,2026,10.1002/advs.76517,https://pubmed.ncbi.nlm.nih.gov/42435767/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42193073,Differential TET1/2/3 Protein Expression in Circulating Leukocytes of Statin-Treated Patients with HFrEF.,2026,10.3390/cimb48050467,https://pubmed.ncbi.nlm.nih.gov/42193073/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42695671,microRNA-27a-3p influences hepatocellular carcinoma cell migration and invasion via the TET1/p53 pathway.,2026,10.1080/17410541.2026.2718045,https://pubmed.ncbi.nlm.nih.gov/42695671/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,41928256,Electroacupuncture activates the TET1/PPARα pathway to protect mitochondrial function in MASLD.,2026,10.1186/s12950-026-00500-1,https://pubmed.ncbi.nlm.nih.gov/41928256/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,41152554,TET1 loss propels the development of hyperthyroidism by remodeling histone modifications of PAX8 promoter.,2025,10.1038/s12276-025-01566-2,https://pubmed.ncbi.nlm.nih.gov/41152554/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,41559134,TET1 suppresses hepatocellular carcinoma progression by modulating the PI3K/Akt signaling pathways.,2026,10.1038/s41598-026-36334-3,https://pubmed.ncbi.nlm.nih.gov/41559134/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42268715,B cell TET2 recruits OGT for nuclear TET2 and H2B O-GlcNAcylation to drive AID and BLIMP-1 expression and maturation of the antibody response.,2026,10.1016/j.celrep.2026.117370,https://pubmed.ncbi.nlm.nih.gov/42268715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,40830820,TET1 methylation and mRNA expression in renal cell carcinoma: implications for tumor staging and prognosis.,2025,10.1186/s40001-025-03051-y,https://pubmed.ncbi.nlm.nih.gov/40830820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42448565,TET1 noncatalytic activity shapes the chromatin landscape associated with de novo methylation establishment in the male germline.,2026,10.1101/gad.353483.125,https://pubmed.ncbi.nlm.nih.gov/42448565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42747979,STK11 deficiency drives NSCLC immune resistance via ETNK2-mediated phosphoethanolamine accumulation.,2026,10.1093/intimm/dxag048,https://pubmed.ncbi.nlm.nih.gov/42747979/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,41559050,TET1 as a master regulator controlling GPX4-dependent and -independent ferroptosis surveillance in acute myeloid leukemia.,2026,10.1038/s41467-026-68509-x,https://pubmed.ncbi.nlm.nih.gov/41559050/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42359646,Regulatory function of ten‑eleven translocation‑2 in transcriptional mechanisms of demethylated myeloma cells.,2026,10.3892/mmr.2026.13947,https://pubmed.ncbi.nlm.nih.gov/42359646/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,40517100,Metabolic Regulation of cGAS-STING Signaling in the Tumor Microenvironment: Dual Immune Roles and Therapeutic Implications.,2025,10.1016/j.cytogfr.2025.06.002,https://pubmed.ncbi.nlm.nih.gov/40517100/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42506101,"TET Enzymes as Epigenetic Integrators in Intestinal Immunity, Inflammation, and Disease.",2026,10.3390/jpm16070375,https://pubmed.ncbi.nlm.nih.gov/42506101/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42624385,Chlorpyrifos exposure remodels the spermatogenic niche and alters testicular epigenetic dynamics in the absence of overt reproductive toxicity.,2026,10.1016/j.reprotox.2026.109330,https://pubmed.ncbi.nlm.nih.gov/42624385/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,40790761,TET1 functions as a tumor suppressor in lung adenocarcinoma through epigenetic remodeling and immune modulation.,2025,10.1186/s13072-025-00617-2,https://pubmed.ncbi.nlm.nih.gov/40790761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,42778210,Gamma-Delta Phenotypic Evolution in Mycosis Fungoides With CD30-Positive Cutaneous Progression.,2026,10.1111/cup.70221,https://pubmed.ncbi.nlm.nih.gov/42778210/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,41291744,Activation of WDHD1 by DNA demethylases promotes MINPP1 transcription and glycolysis in lung adenocarcinoma progression.,2025,10.1186/s12931-025-03399-z,https://pubmed.ncbi.nlm.nih.gov/41291744/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,40161258,Protective effects of corn silk and &lt;i&gt;asparagus Officinalis&lt;/i&gt; against formaldehyde-induced reproductive toxicity in male rats via CDK2/Spem1/Fbxo47 and Tet1 pathways.,2025,10.1093/toxres/tfaf039,https://pubmed.ncbi.nlm.nih.gov/40161258/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,41547069,Cannabidiol inhibits melanoma progression by regulating PPARγ-TET1 complex-dependent LRSAM1 demethylation.,2026,10.1016/j.phymed.2026.157775,https://pubmed.ncbi.nlm.nih.gov/41547069/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,41362610,High matrix stiffness triggers the YAP-OPA1-TET1/3 loop to drive chemoresistance via enhanced nuclear-mitochondrial communication.,2025,10.1016/j.isci.2025.113996,https://pubmed.ncbi.nlm.nih.gov/41362610/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,28531272,A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer.,2017,10.1093/nar/gkx435,https://pubmed.ncbi.nlm.nih.gov/28531272/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,25284789,5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.,2014,10.1016/j.celrep.2014.08.071,https://pubmed.ncbi.nlm.nih.gov/25284789/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,12646957,"TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).",2003,10.1038/sj.leu.2402834,https://pubmed.ncbi.nlm.nih.gov/12646957/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TET1,ENSG00000138336,Unsafe,12124344,"LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23).",2002,,https://pubmed.ncbi.nlm.nih.gov/12124344/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,41411337,Contrasting effects of DNA demethylation on cancer-germline gene expression in breast cancer and leukemia cells.,2025,10.1371/journal.pone.0339460,https://pubmed.ncbi.nlm.nih.gov/41411337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,42450230,Seminal-Plasma Molecular Biomarkers as a Liquid Biopsy of Testicular Function: Toward AI-Ready Sperm-Retrieval Prediction in Non-Obstructive Azoospermia.,2026,10.3390/ijms27135965,https://pubmed.ncbi.nlm.nih.gov/42450230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,39208330,"Differential expression and regulation of ADAD1, DMRTC2, PRSS54, SYCE1, SYCP1, TEX101, TEX48, and TMPRSS12 gene profiles in colon cancer tissues and their in vitro response to epigenetic drugs.",2024,10.1371/journal.pone.0307724,https://pubmed.ncbi.nlm.nih.gov/39208330/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,41594507,Doppler Waveform Alterations of the Supratesticular Artery and Associated Semen Biomarkers in Infertile Male Dromedary Camels.,2026,10.3390/ani16020319,https://pubmed.ncbi.nlm.nih.gov/41594507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,41398765,A cancer-testis antigen signature for predicting prognosis and response to immunotherapy in acute myeloid leukemia.,2025,10.1097/md.0000000000046374,https://pubmed.ncbi.nlm.nih.gov/41398765/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,35774118,A Role of the TEX101 Interactome in the Common Aetiology Behind Male Subfertility and Testicular Germ Cell Tumor.,2022,10.3389/fonc.2022.892043,https://pubmed.ncbi.nlm.nih.gov/35774118/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,39126002,Quantitative Proteomic Analysis Reveals Key Proteins Involved in Testicular Development of Yaks.,2024,10.3390/ijms25158433,https://pubmed.ncbi.nlm.nih.gov/39126002/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,40952146,"Navigating male infertility through testicular biopsy: outcomes, predictive parameters, and surgical innovation.",2025,10.1080/19396368.2025.2551006,https://pubmed.ncbi.nlm.nih.gov/40952146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,37568830,Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins.,2023,10.3390/diagnostics13152468,https://pubmed.ncbi.nlm.nih.gov/37568830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,39767586,Predictors of Successful Testicular Sperm Extraction: A New Era for Men with Non-Obstructive Azoospermia.,2024,10.3390/biomedicines12122679,https://pubmed.ncbi.nlm.nih.gov/39767586/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,40041504,Identification of reproductive performance in Bali-polled bulls using computer-assisted semen analysis and plasma seminal proteomics.,2025,10.14202/vetworld.2025.102-109,https://pubmed.ncbi.nlm.nih.gov/40041504/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,39183752,Age-dependent variations in proteomic characteristics of spermatozoa in Simmental bull.,2024,10.3389/fvets.2024.1393706,https://pubmed.ncbi.nlm.nih.gov/39183752/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,39546127,Survival prediction in patients with head and neck squamous cell carcinoma and novel mechanistic insights of S100A8/A9.,2024,10.1007/s12672-024-01540-w,https://pubmed.ncbi.nlm.nih.gov/39546127/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,32927778,Role of the Glycosylphosphatidylinositol-Anchored Protein TEX101 and Its Related Molecules in Spermatogenesis.,2020,10.3390/ijms21186628,https://pubmed.ncbi.nlm.nih.gov/32927778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,41328241,Proteomic analysis of seminal plasma in Bali-polled bulls: Identifying biomarkers for fertility assessment.,2025,10.5455/javar.2025.l933,https://pubmed.ncbi.nlm.nih.gov/41328241/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,30429210,Identification of TEX101-associated Proteins Through Proteomic Measurement of Human Spermatozoa Homozygous for the Missense Variant rs35033974.,2019,10.1074/mcp.ra118.001170,https://pubmed.ncbi.nlm.nih.gov/30429210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,30097533,Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies.,2018,10.1074/mcp.ra118.000749,https://pubmed.ncbi.nlm.nih.gov/30097533/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,37076787,Seminal plasma biomarkers for predicting successful sperm retrieval in patients with nonobstructive azoospermia: a narrative review of human studies.,2023,10.1186/s12610-023-00184-0,https://pubmed.ncbi.nlm.nih.gov/37076787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,34101112,Dysregulation of Notch-FGF signaling axis in germ cells results in cystic dilation of the rete testis in mice.,2022,10.1007/s12079-021-00628-0,https://pubmed.ncbi.nlm.nih.gov/34101112/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,28330469,Preclinical evaluation of a TEX101 protein ELISA test for the differential diagnosis of male infertility.,2017,10.1186/s12916-017-0817-5,https://pubmed.ncbi.nlm.nih.gov/28330469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,31635267,The Impact of the Antigenic Composition of Chimeric Proteins on Their Immunoprotective Activity against Chronic Toxoplasmosis in Mice.,2019,10.3390/vaccines7040154,https://pubmed.ncbi.nlm.nih.gov/31635267/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,33892811,Prognostic biomarkers and therapeutic targets in oral squamous cell carcinoma: a study based on cross-database analysis.,2021,10.1186/s41065-021-00181-1,https://pubmed.ncbi.nlm.nih.gov/33892811/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,22588436,"Expression of testis-specific genes, TEX101 and ODF4, in chronic myeloid leukemia and evaluation of TEX101 immunogenicity.",2012,10.5144/0256-4947.2012.256,https://pubmed.ncbi.nlm.nih.gov/22588436/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,23396665,"Expression of Testis Specific Genes TSGA10, TEX101 and ODF3 in Breast Cancer.",2012,10.5812/ircmj.3611,https://pubmed.ncbi.nlm.nih.gov/23396665/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,25994570,"Transcriptome analysis of the cancer/testis genes, DAZ1, AURKC, and TEX101, in breast tumors and six breast cancer cell lines.",2015,10.1007/s13277-015-3546-4,https://pubmed.ncbi.nlm.nih.gov/25994570/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,35117201,Comprehensive analysis reveals novel gene signature in head and neck squamous cell carcinoma: predicting is associated with poor prognosis in patients.,2020,10.21037/tcr-20-805,https://pubmed.ncbi.nlm.nih.gov/35117201/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,34992636,Whole Genome Methylation Analysis Reveals Role of DNA Methylation in Cow's Ileal and Ileal Lymph Node Responses to Mycobacterium avium subsp. paratuberculosis Infection.,2021,10.3389/fgene.2021.797490,https://pubmed.ncbi.nlm.nih.gov/34992636/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,19886887,Elevated expression levels of testis-specific genes TEX101 and SPATA19 in basal cell carcinoma and their correlation with clinical and pathological features.,2010,10.1111/j.1365-2133.2009.09568.x,https://pubmed.ncbi.nlm.nih.gov/19886887/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,16516155,A novel spermatogenesis-specific uPAR gene expressed in human and mouse testis.,2006,10.1016/j.bbrc.2006.01.175,https://pubmed.ncbi.nlm.nih.gov/16516155/,annotation citations | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX101,ENSG00000131126,Unsafe,27157261,A gonogenic stimulated transition of mouse embryonic stem cells with enhanced control of diverse differentiation pathways.,2016,10.1038/srep25104,https://pubmed.ncbi.nlm.nih.gov/27157261/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,41300722,Is the TEX11-.652del237bp Exonic In-Frame Deletion Variant Associated with Azoospermia? The Results of an &lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Silico&lt;/i&gt; Study.,2025,10.3390/genes16111270,https://pubmed.ncbi.nlm.nih.gov/41300722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,42324855,Variants in ZZS Complex-Associated Genes TEX11 and M1AP Are Responsible for Male Infertility and Nonobstructive Azoospermia.,2026,10.1111/andr.70291,https://pubmed.ncbi.nlm.nih.gov/42324855/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,42381596,eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes.,2026,10.1002/advs.76264,https://pubmed.ncbi.nlm.nih.gov/42381596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,42019764,"ZIP4 protects against CCl&lt;sub&gt;4&lt;/sub&gt;-induced liver fibrosis by regulating zinc homeostasis, oxidative stress, and ferroptosis.",2026,10.1016/j.freeradbiomed.2026.04.138,https://pubmed.ncbi.nlm.nih.gov/42019764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,39231187,A partial deletion within the meiosis-specific sporulation domain SPO22 of Tex11 is not associated with infertility in mice.,2024,10.1371/journal.pone.0309974,https://pubmed.ncbi.nlm.nih.gov/39231187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,42001942,Zinc-induced exposure of an LxL motif drives clathrin-mediated endocytosis of the zinc transceptor ZIP4.,2026,10.1016/j.jbc.2026.111472,https://pubmed.ncbi.nlm.nih.gov/42001942/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,42258546,XPF-like domain in human SHOC1 is required for crossover formation and protecting autosome from MSUC.,2026,10.1093/nar/gkag558,https://pubmed.ncbi.nlm.nih.gov/42258546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,41803029,Novel PMVs/ZIP4/Zinc/Prelamin A Axis Promotes Nuclear Dysmorphism and Vascular Aging in Humans and Rodents Post-Injury: Effective Treatment With Platelet Membrane-Coated ZIF-8 Nanoparticles.,2026,10.1111/acel.70443,https://pubmed.ncbi.nlm.nih.gov/41803029/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,40869403,Zinc Transporters of the LIV-1 Subfamily in Various Cancers: Molecular Insights and Research Priorities for Saudi Arabia.,2025,10.3390/ijms26168080,https://pubmed.ncbi.nlm.nih.gov/40869403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,41182569,Exploring the prognostic value and biomarker of TEX11 in breast cancer via PANoptosis.,2026,10.1007/s12282-025-01794-4,https://pubmed.ncbi.nlm.nih.gov/41182569/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,41459538,"Identification and validation of biomarkers related to centrosome replication in ulcerative colitis based on bulk transcriptome, single-cell RNA sequencing and experiments.",2025,10.3389/fimmu.2025.1627926,https://pubmed.ncbi.nlm.nih.gov/41459538/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,40305049,A zinc transporter drives glioblastoma progression via extracellular vesicles-reprogrammed microglial plasticity.,2025,10.1073/pnas.2427073122,https://pubmed.ncbi.nlm.nih.gov/40305049/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,42814503,Immunomagnetic-MXene Bifunctional Probes for Ultrasensitive and Specific Terahertz Metasensing of Tumor-Derived Exosomes.,2026,10.1002/advs.78093,https://pubmed.ncbi.nlm.nih.gov/42814503/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,39417191,ZIP4: a promising early diagnostic and therapeutic targets for pancreatic cancer.,2024,10.62347/avym3477,https://pubmed.ncbi.nlm.nih.gov/39417191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,38217540,ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis.,2024,10.18632/aging.205412,https://pubmed.ncbi.nlm.nih.gov/38217540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,42059593,"The synaptonemal complex: structure, function, and clinical implications†.",2026,10.1093/biolre/ioag092,https://pubmed.ncbi.nlm.nih.gov/42059593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,41602521,Accumulation of ph1 (zip4-5B) and ph2 (msh7-3D) mutations fails to boost homoeologous recombination in hexaploid wheat.,2025,10.3389/fpls.2025.1733533,https://pubmed.ncbi.nlm.nih.gov/41602521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,39664563,"Research progress on the molecular structure, function, and application in tumor therapy of zinc transporter ZIP4.",2024,10.7150/ijbs.102460,https://pubmed.ncbi.nlm.nih.gov/39664563/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,40694934,Gonadal sex differentiation in Eleutheronema tetradactylum: Histological features and transcriptomic insights from mature gonads.,2025,10.1016/j.cbd.2025.101586,https://pubmed.ncbi.nlm.nih.gov/40694934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,42628183,Enhanced cadmium phytoextraction in Brassica juncea by a hyperaccumulator-sourced synthetic inoculant.,2026,10.1016/j.ecoenv.2026.120696,https://pubmed.ncbi.nlm.nih.gov/42628183/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,41586242,Supplementation of zinc-chelating peptides from &lt;i&gt;Holothuria scabra&lt;/i&gt; improve zinc status in the offspring of zinc-deficient rats.,2025,10.3389/fnut.2025.1693713,https://pubmed.ncbi.nlm.nih.gov/41586242/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,39283041,Validation of ZIP4 as a tumour-associated antigen for nanotargeting.,2025,10.1080/1061186x.2024.2405711,https://pubmed.ncbi.nlm.nih.gov/39283041/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,38367035,Role of zinc in health and disease.,2024,10.1007/s10238-024-01302-6,https://pubmed.ncbi.nlm.nih.gov/38367035/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,39147518,Zn&lt;sup&gt;2+&lt;/sup&gt; chelating peptide GFLGSP: Characterization of structure/Zn&lt;sup&gt;2+&lt;/sup&gt; chelating mode and the potential mechanisms for promoting Zn&lt;sup&gt;2+&lt;/sup&gt; transport in Caco-2 cells.,2024,10.1016/j.foodres.2024.114829,https://pubmed.ncbi.nlm.nih.gov/39147518/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,41036460,"Preparation, characterization, assembly, and stability of walnut peptide - zinc complexes and its ability to promote zinc transport in Caco-2 cells.",2025,10.1016/j.fochx.2025.103046,https://pubmed.ncbi.nlm.nih.gov/41036460/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,40513488,Zinc-binding mechanism of synthetic oyster peptides and their taste sensory characteristics: Insight into umami and saltiness perception.,2025,10.1016/j.foodchem.2025.145077,https://pubmed.ncbi.nlm.nih.gov/40513488/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,41824266,"Effects of Copper Glycinate Replacing High-Dose Copper Sulfate on Growth Performance, Trace Element Metabolism and Stem Cell Activity in Growing Pigs.",2026,10.1007/s12011-026-05041-5,https://pubmed.ncbi.nlm.nih.gov/41824266/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,39128710,Determination of metal ion transport rate of human ZIP4 using stable zinc isotopes.,2024,10.1016/j.jbc.2024.107661,https://pubmed.ncbi.nlm.nih.gov/39128710/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,37666630,Cell-based transport assay to study kinetics and substrate specificity of human ZIPs.,2023,10.1016/bs.mie.2023.05.013,https://pubmed.ncbi.nlm.nih.gov/37666630/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,41466218,"Role of chromosome ends in meiotic stability, recombination and wheat evolution in the context of breeding.",2025,10.1186/s12870-025-08020-5,https://pubmed.ncbi.nlm.nih.gov/41466218/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,38072947,Psoralen synergies with zinc implants to promote bone repair by regulating ZIP4 in rats with bone defect.,2023,10.1186/s40824-023-00472-w,https://pubmed.ncbi.nlm.nih.gov/38072947/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,41923320,Effects of potentiated zinc oxide and crude protein levels in low acid-binding capacity diets on growth performance and mineral status in nursery pigs.,2026,10.1093/jas/skag091,https://pubmed.ncbi.nlm.nih.gov/41923320/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,38996680,Transcriptome-wide m&lt;sup&gt;6&lt;/sup&gt;A methylation profile reveals tissue specific regulatory networks in switchgrass (Panicum virgatum L.) under cadmium stress.,2024,10.1016/j.jhazmat.2024.134904,https://pubmed.ncbi.nlm.nih.gov/38996680/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX11,ENSG00000120498,Unsafe,18369460,ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over.,2008,10.1371/journal.pgen.1000042,https://pubmed.ncbi.nlm.nih.gov/18369460/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,42792869,Ubc9 Mediates SUMO2/3 Modification to Regulate Meiosis in Male Mice.,2026,10.3390/biomedicines14092129,https://pubmed.ncbi.nlm.nih.gov/42792869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,41467312,SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis.,2026,10.1111/cpr.70158,https://pubmed.ncbi.nlm.nih.gov/41467312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,42059593,"The synaptonemal complex: structure, function, and clinical implications†.",2026,10.1093/biolre/ioag092,https://pubmed.ncbi.nlm.nih.gov/42059593/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,34880391,Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12.,2021,10.1038/s42003-021-02887-4,https://pubmed.ncbi.nlm.nih.gov/34880391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,42411655,Genomic Analysis Revealed Hotspots of Genetic Adaptation and Risk of Disappearance in Brazilian Goat Populations.,2026,10.31083/fbs43536,https://pubmed.ncbi.nlm.nih.gov/42411655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,36071143,Coiled-coil structure of meiosis protein TEX12 and conformational regulation by its C-terminal tip.,2022,10.1038/s42003-022-03886-9,https://pubmed.ncbi.nlm.nih.gov/36071143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,40332359,Single-Cell Transcriptomic Analysis of the Potential Mechanisms of Follicular Development in &lt;i&gt;Stra8&lt;/i&gt;-Deficient Mice.,2025,10.3390/ijms26083734,https://pubmed.ncbi.nlm.nih.gov/40332359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,29932616,"Expression analysis of genes encoding TEX11, TEX12, TEX14 and TEX15 in testis tissues of men with non-obstructive azoospermia.",2018,10.5935/1518-0557.20180030,https://pubmed.ncbi.nlm.nih.gov/29932616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,36635604,Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3.,2023,10.1038/s41594-022-00909-1,https://pubmed.ncbi.nlm.nih.gov/36635604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,34373646,Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12.,2021,10.1038/s41594-021-00636-z,https://pubmed.ncbi.nlm.nih.gov/34373646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,35368888,Identify a DNA Damage Repair Gene Signature for Predicting Prognosis and Immunotherapy Response in Cervical Squamous Cell Carcinoma.,2022,10.1155/2022/8736575,https://pubmed.ncbi.nlm.nih.gov/35368888/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,34969823,The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly.,2022,10.1101/gad.348973.121,https://pubmed.ncbi.nlm.nih.gov/34969823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,31023827,A molecular model for self-assembly of the synaptonemal complex protein SYCE3.,2019,10.1074/jbc.ra119.008404,https://pubmed.ncbi.nlm.nih.gov/31023827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,30958977,Genome-wide association study of four composite reproductive traits in Iranian fat-tailed sheep.,2019,10.1071/rd18282,https://pubmed.ncbi.nlm.nih.gov/30958977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,34253331,Deoxyribonucleic acid methylation signatures in sperm deoxyribonucleic acid fragmentation.,2021,10.1016/j.fertnstert.2021.06.025,https://pubmed.ncbi.nlm.nih.gov/34253331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,22870393,Structural analysis of the human SYCE2-TEX12 complex provides molecular insights into synaptonemal complex assembly.,2012,10.1098/rsob.120099,https://pubmed.ncbi.nlm.nih.gov/22870393/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,25831978,Protein SYCP2 is an ancient component of the metazoan synaptonemal complex.,2014,10.1159/000381080,https://pubmed.ncbi.nlm.nih.gov/25831978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,22854038,Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes.,2012,10.1242/jcs.105015,https://pubmed.ncbi.nlm.nih.gov/22854038/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,16968740,Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex.,2006,10.1242/jcs.03182,https://pubmed.ncbi.nlm.nih.gov/16968740/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX12,ENSG00000150783,Unsafe,30607510,Molecular structure of human synaptonemal complex protein SYCE1.,2019,10.1007/s00412-018-00688-z,https://pubmed.ncbi.nlm.nih.gov/30607510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX26,ENSG00000175664,Unsafe,41890232,Promoter hypomethylation of &lt;i&gt;CDH7&lt;/i&gt;: a novel epigenetic marker associated with cerebral small vessel disease.,2026,10.3389/fgene.2026.1780415,https://pubmed.ncbi.nlm.nih.gov/41890232/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX26,ENSG00000175664,Unsafe,39306700,Implementation of the Methyl-Seq platform to identify tissue- and sex-specific DNA methylation differences in the rat epigenome.,2024,10.1080/15592294.2024.2393945,https://pubmed.ncbi.nlm.nih.gov/39306700/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX26,ENSG00000175664,Unsafe,40564006,Effect of Recombinant Human Growth Hormone (rhGH) Use on Genetic Methylation Patterns and Their Relationship with Body Composition in Small-for-Gestational-Age (SGA) Newborns.,2025,10.3390/biomedicines13061288,https://pubmed.ncbi.nlm.nih.gov/40564006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX26,ENSG00000175664,Unsafe,36349462,Comprehensive analysis of HHV-6 and HHV-7-related gene signature in prognosis and response to temozolomide of glioma.,2023,10.1002/jmv.28285,https://pubmed.ncbi.nlm.nih.gov/36349462/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX26,ENSG00000175664,Unsafe,36244801,Sex-Specific Genetic and Transcriptomic Liability to Neuroticism.,2023,10.1016/j.biopsych.2022.07.019,https://pubmed.ncbi.nlm.nih.gov/36244801/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX26,ENSG00000175664,Unsafe,32686835,Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models.,2020,10.1093/hmg/ddaa140,https://pubmed.ncbi.nlm.nih.gov/32686835/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX26,ENSG00000175664,Unsafe,30362198,Comprehensive analysis of coexpressed long noncoding RNAs and genes in breast cancer.,2019,10.1111/jog.13840,https://pubmed.ncbi.nlm.nih.gov/30362198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX26,ENSG00000175664,Unsafe,30911093,Genome-wide association study of blood lipids in Indians confirms universality of established variants.,2019,10.1038/s10038-019-0591-7,https://pubmed.ncbi.nlm.nih.gov/30911093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX26,ENSG00000175664,Unsafe,26117173,Distinct differences in global gene expression profiles in non-implanted blastocysts and blastocysts resulting in live birth.,2015,10.1016/j.gene.2015.06.057,https://pubmed.ncbi.nlm.nih.gov/26117173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX29,ENSG00000153495,Unsafe,42176103,TEX29 is a novel acrosome marker dispensable for spermatogenesis and fertilization in mice.,2026,10.1007/s10815-026-03907-0,https://pubmed.ncbi.nlm.nih.gov/42176103/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX29,ENSG00000153495,Unsafe,42881083,4D-DIA proteomics unveils the dual engines of human sperm capacitation.,2026,10.1016/j.repbio.2026.101290,https://pubmed.ncbi.nlm.nih.gov/42881083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX29,ENSG00000153495,Unsafe,40394719,"Identifying GAP43, NMU, and TEX29 as Potential Prognostic Biomarkers for COPD Combined With Lung Cancer Patients Using Machine Learning.",2025,10.1002/jgm.70020,https://pubmed.ncbi.nlm.nih.gov/40394719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX29,ENSG00000153495,Unsafe,38869630,Characterizing Common and Rare Variations in Nontraditional Glycemic Biomarkers Using Multivariate Approaches on Multiancestry ARIC Study.,2024,10.2337/db23-0318,https://pubmed.ncbi.nlm.nih.gov/38869630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX29,ENSG00000153495,Unsafe,37018654,Human skeletal muscle methylome after low-carbohydrate energy-balanced exercise.,2023,10.1152/ajpendo.00029.2023,https://pubmed.ncbi.nlm.nih.gov/37018654/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX29,ENSG00000153495,Unsafe,30174296,Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis.,2018,10.1016/j.stem.2018.08.007,https://pubmed.ncbi.nlm.nih.gov/30174296/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX29,ENSG00000153495,Unsafe,31788056,DNA methylation profiling analysis identifies a DNA methylation signature for predicting prognosis and recurrence of lung adenocarcinoma.,2019,10.3892/ol.2019.10931,https://pubmed.ncbi.nlm.nih.gov/31788056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX30,ENSG00000151287,Unsafe,41689187,TEX30 safeguards sperm morphogenesis and quality consistency required for male fertility.,2026,10.1093/reprod/xaag022,https://pubmed.ncbi.nlm.nih.gov/41689187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX30,ENSG00000151287,Unsafe,40704729,Loss of TEX30 leads to male subfertility in mice.,2025,10.1093/biolre/ioaf163,https://pubmed.ncbi.nlm.nih.gov/40704729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX30,ENSG00000151287,Unsafe,37594251,Scrutinizing the human TEX genes in the context of human male infertility.,2024,10.1111/andr.13511,https://pubmed.ncbi.nlm.nih.gov/37594251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX30,ENSG00000151287,Unsafe,30762239,DNA methylation and allergic sensitizations: A genome-scale longitudinal study during adolescence.,2019,10.1111/all.13746,https://pubmed.ncbi.nlm.nih.gov/30762239/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX30,ENSG00000151287,Unsafe,23158542,Genomic profiling of rectal adenoma and carcinoma by array-based comparative genomic hybridization.,2012,10.1186/1755-8794-5-52,https://pubmed.ncbi.nlm.nih.gov/23158542/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX55,ENSG00000163424,Unsafe,33458765,Tex55 encodes a conserved putative A-kinase anchoring protein dispensable for male fertility in the mouse.,2021,10.1093/biolre/ioab007,https://pubmed.ncbi.nlm.nih.gov/33458765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX55,ENSG00000163424,Unsafe,19821082,"Expression profile of a novel germ cell-specific gene, TSCPA, in mice and human.",2009,10.1007/s11596-009-0502-9,https://pubmed.ncbi.nlm.nih.gov/19821082/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX9,ENSG00000151575,Unsafe,42079374,Insights into Human Ciliopathies: Gene Silencing of &lt;i&gt;ropn1l&lt;/i&gt; and &lt;i&gt;tex9&lt;/i&gt; in &lt;i&gt;Schmidtea&lt;/i&gt; &lt;i&gt;mediterranea&lt;/i&gt; Indicate Association with Ciliary Structure and Motility.,2026,10.17912/micropub.biology.002035,https://pubmed.ncbi.nlm.nih.gov/42079374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX9,ENSG00000151575,Unsafe,42348320,Microtubule-associated CCDC112 is essential for spermiogenesis and male fertility in mice.,2026,10.1093/jmcb/mjag019,https://pubmed.ncbi.nlm.nih.gov/42348320/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX9,ENSG00000151575,Unsafe,37594251,Scrutinizing the human TEX genes in the context of human male infertility.,2024,10.1111/andr.13511,https://pubmed.ncbi.nlm.nih.gov/37594251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX9,ENSG00000151575,Unsafe,31481019,TEX9 and eIF3b functionally synergize to promote the progression of esophageal squamous cell carcinoma.,2019,10.1186/s12885-019-6071-9,https://pubmed.ncbi.nlm.nih.gov/31481019/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX9,ENSG00000151575,Unsafe,33064489,The Functionally Unannotated Proteome of Human Male Tissues: A Shared Resource to Uncover New Protein Functions Associated with Reproductive Biology.,2020,10.1021/acs.jproteome.0c00516,https://pubmed.ncbi.nlm.nih.gov/33064489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX9,ENSG00000151575,Unsafe,28770278,An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection.,2017,10.1007/s00262-017-2047-2,https://pubmed.ncbi.nlm.nih.gov/28770278/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TEX9,ENSG00000151575,Unsafe,28460059,Insights into Ciliary Genes and Evolution from Multi-Level Phylogenetic Profiling.,2017,10.1093/molbev/msx146,https://pubmed.ncbi.nlm.nih.gov/28460059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,42313930,TFPI2 promotes NK cell-mediated glioblastoma killing through adhesion and checkpoint control.,2026,10.1073/pnas.2529973123,https://pubmed.ncbi.nlm.nih.gov/42313930/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,42619388,FOXO4 enhances high glucose-induced HK-2 cell damage and inflammation by targeting TFPI2 in diabetic nephropathy.,2026,10.23876/j.krcp.25.389,https://pubmed.ncbi.nlm.nih.gov/42619388/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,42349846,Tissue Factor Pathway Inhibitor-2 (TFPI2) as a Biomarker in Gynecologic Malignancies: A Narrative Review Focusing on Clear Cell Carcinoma.,2026,10.1111/jog.70344,https://pubmed.ncbi.nlm.nih.gov/42349846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,42216563,TFPI2 in tumor metastasis: a double-edged sword with clinical implications.,2026,10.1080/15384047.2026.2678642,https://pubmed.ncbi.nlm.nih.gov/42216563/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,41842961,Symbiotic exclusivity between CLOCK and TFPI2 drives stemness and immunosuppression in glioblastoma models.,2026,10.1172/jci199056,https://pubmed.ncbi.nlm.nih.gov/41842961/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,42171882,TFPI2 expression predicts resistance to immunotherapy plus tyrosine kinase inhibitor and informs first-line therapy selection in metastatic renal cell carcinoma.,2026,10.1007/s13402-026-01224-3,https://pubmed.ncbi.nlm.nih.gov/42171882/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,40361374,Reassessing the Role of Tissue Factor Pathway Inhibitor 2 in Neoplastic and Non-Neoplastic Lesions.,2025,10.3390/cancers17091447,https://pubmed.ncbi.nlm.nih.gov/40361374/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,41695361,"Stool-based SDC2/SFRP2/TFPI2 methylation assay for colorectal neoplasia screening: a multicenter, case-control study.",2026,10.3389/fonc.2026.1748759,https://pubmed.ncbi.nlm.nih.gov/41695361/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,42745340,TNFα-induced endothelial extracellular vesicles regulate astrocyte function: an integrated transcriptomic and proteomic study.,2026,10.1186/s12987-026-00851-0,https://pubmed.ncbi.nlm.nih.gov/42745340/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,41932065,Trophoblast KHSRP deficiency induces DNA damage and apoptosis via TFPI2 in unexplained spontaneous miscarriage.,2026,10.1016/j.placenta.2026.03.022,https://pubmed.ncbi.nlm.nih.gov/41932065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,39562727,Tissue factor pathway inhibitor 2 (TFPI2) is a potential serum biomarker for clear cell renal carcinoma.,2024,10.1038/s41598-024-80248-x,https://pubmed.ncbi.nlm.nih.gov/39562727/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,40765823,Tissue Factor Pathway Inhibitor 2 Enhances Hepatocellular Carcinoma Chemosensitivity by Activating CCAR2-GADD45A-Mediated DNA Damage Repair.,2025,10.7150/ijbs.111142,https://pubmed.ncbi.nlm.nih.gov/40765823/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,40889548,Microenvironmental TFPI2 in Hirschsprung Disease: Mechanisms in ENCC Development.,2025,10.1016/j.jpedsurg.2025.162625,https://pubmed.ncbi.nlm.nih.gov/40889548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,40765756,Combined Methylation Analysis of SDC2 and TFPI2 in Plasma: A Noninvasive Liquid Biopsy Approach for Early Detection of Colorectal Polyp.,2025,10.22088/ijmcm.bums.14.2.646,https://pubmed.ncbi.nlm.nih.gov/40765756/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,40800606,"Transcriptome analysis of serum biomarker, shared gene signature and pharmacological targets between diabetic cardiomyopathy and nephropathy.",2025,10.1016/j.bbrep.2025.102194,https://pubmed.ncbi.nlm.nih.gov/40800606/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,42433374,From islet to blood: macrophage remodeling signatures for diagnosis and risk stratification in type 1 diabetes.,2026,10.3389/fimmu.2026.1832672,https://pubmed.ncbi.nlm.nih.gov/42433374/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,39192208,Tissue factor pathway inhibitor 2 as a serum biomarker for endometrial cancer: a single-center retrospective study.,2024,10.1186/s12885-024-12827-0,https://pubmed.ncbi.nlm.nih.gov/39192208/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,42138075,Uncovering a feedback loop in glioblastoma that reinforces stemness and immunosuppression.,2026,10.1172/jci205841,https://pubmed.ncbi.nlm.nih.gov/42138075/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,40525287,Tissue Factor Pathway Inhibitor-2 Expression in Uterine Cervical Clear Cell Carcinoma: A Potential Biomarker for Clinical Diagnosis.,2025,10.1097/pai.0000000000001270,https://pubmed.ncbi.nlm.nih.gov/40525287/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,42840404,Development of an application for colorectal cancer prediction using SDC2 and TFPI2 methylation: an opportunity for early and noninvasive diagnosis in Latin-America.,2026,10.3389/fmolb.2026.1922606,https://pubmed.ncbi.nlm.nih.gov/42840404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,40277888,"Glioblastoma Stem Cells at the Nexus of Tumor Heterogeneity, Immune Evasion, and Therapeutic Resistance.",2025,10.3390/cells14080562,https://pubmed.ncbi.nlm.nih.gov/40277888/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,41815145,Identification and validation of a novel estrogen-related model for breast cancer to predict the prognosis.,2026,10.21037/tcr-2025-1409,https://pubmed.ncbi.nlm.nih.gov/41815145/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,39154703,Restoration of TFPI2 by LSD1 inhibition suppresses tumor progression and potentiates antitumor immunity in breast cancer.,2024,10.1016/j.canlet.2024.217182,https://pubmed.ncbi.nlm.nih.gov/39154703/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,40244374,miR-130a-5p/TFPI2 axis promotes invasion of hepatocellular carcinoma by altering epithelial-to-mesenchymal transition.,2025,10.1007/s12672-025-02296-7,https://pubmed.ncbi.nlm.nih.gov/40244374/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,39971476,Assessment of tissue factor pathway inhibitor 2 (TFPI2) as a novel serum marker for malignant tumors of the ovary before and after treatment: A case-control study.,2025,10.1111/jog.16241,https://pubmed.ncbi.nlm.nih.gov/39971476/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,37667051,Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma.,2023,10.1038/s41590-023-01605-y,https://pubmed.ncbi.nlm.nih.gov/37667051/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,40422184,Identification of Prognostic Biomarkers of Ovarian High-Grade Serous Carcinoma: A Preliminary Study Using Spatial Transcriptome Analysis and Multispectral Imaging.,2025,10.3390/cells14100681,https://pubmed.ncbi.nlm.nih.gov/40422184/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,42007152,A novel prognostic signature based on epithelial-mesenchymal transition-associated genes for the prognosis and immune status in breast cancer.,2026,10.62347/jqqx7009,https://pubmed.ncbi.nlm.nih.gov/42007152/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TFPI2,ENSG00000105825,Unsafe,41270582,Harnessing dental stem cell-derived synovial cells for IBD therapy: dual modulation of gut immunity and crypt repair.,2025,10.1016/j.ebiom.2025.106039,https://pubmed.ncbi.nlm.nih.gov/41270582/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,41748276,Testing insulin-like growth factor messenger RNA-binding protein 3 as a surrogate immunohistochemical marker for indeterminate thyroid nodules with THADA fusion in both cytologic and surgical specimens.,2026,10.1002/cncy.70076,https://pubmed.ncbi.nlm.nih.gov/41748276/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,41751935,"Pathophysiological Roles of Two Intracellular P-Type ATPases: The Cancer-Associated Na&lt;sup&gt;+&lt;/sup&gt;,K&lt;sup&gt;+&lt;/sup&gt;-ATPase α3 Isoform and the Parkinson's Disease-Related ATP13A2.",2026,10.3390/ijms27041800,https://pubmed.ncbi.nlm.nih.gov/41751935/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,42232812,Physiological classification of Parkinson's disease severity using multimodal speech biomarkers with a hybrid CNN-Mamba framework.,2026,10.3389/fphys.2026.1806415,https://pubmed.ncbi.nlm.nih.gov/42232812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,42030275,The stress reduction potential of Bhagavad Gita and Yoga for healthcare workers during the COVID-19 pandemic: A randomized controlled trial.,2026,10.1371/journal.pone.0347320,https://pubmed.ncbi.nlm.nih.gov/42030275/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,42319597,CAN the variants in the THADA and ADAMST9 genes be common risk factors for type 2 diabetes development and obesity.,2026,10.1007/s11033-026-12184-0,https://pubmed.ncbi.nlm.nih.gov/42319597/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,42703834,Phenotype-Specific Association of &lt;i&gt;LHCGR&lt;/i&gt; rs13405728 Polymorphism with Anovulatory Infertility in Malay Women with Polycystic Ovary Syndrome: A Case-Control Study.,2026,10.22074/ijfs.2025.2065767.1908,https://pubmed.ncbi.nlm.nih.gov/42703834/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,42869755,Parkinson's Disease Detection Using Empirical Fourier Decomposition of Speech Signal.,2026,10.1016/j.jvoice.2026.09.051,https://pubmed.ncbi.nlm.nih.gov/42869755/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,41702252,"Understanding social media addiction through Ayurveda, Yoga, and Neuroscience: A narrative review anchored in Indian Knowledge Systems.",2026,10.1016/j.jaim.2025.101293,https://pubmed.ncbi.nlm.nih.gov/41702252/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,40483304,Structural insights into tRNA recognition of the human FTSJ1-THADA complex.,2025,10.1038/s42003-025-08278-3,https://pubmed.ncbi.nlm.nih.gov/40483304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,38561668,Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect.,2024,10.1186/s12576-024-00914-7,https://pubmed.ncbi.nlm.nih.gov/38561668/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,41247892,A Novel Approach to Distinguish Parkinson's Disease Patients From Healthy Control Subjects Using Speech-Based Task Analysis.,2026,10.1109/jbhi.2025.3633456,https://pubmed.ncbi.nlm.nih.gov/41247892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,41300169,Speech Markers of Parkinson's Disease: Phonological Features and Acoustic Measures.,2025,10.3390/brainsci15111162,https://pubmed.ncbi.nlm.nih.gov/41300169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,41459278,Lived experiences of spiritual emotional intelligence: a &lt;i&gt;Bhagavad Gitā&lt;/i&gt;-based indigenous model of psychological wellbeing.,2025,10.3389/fpsyg.2025.1730103,https://pubmed.ncbi.nlm.nih.gov/41459278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,40021270,"The Bhagavad Gita, Psychological Safety, and the Medical Learning Environment: Hitting the Sweet Spot.",2025,10.1016/j.jacadv.2024.101458,https://pubmed.ncbi.nlm.nih.gov/40021270/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,38234670,THADA inhibits autophagy and increases 5-FU sensitivity in gastric cancer cells via the PI3K/AKT/mTOR signaling pathway.,2024,10.22038/ijbms.2023.72055.15668,https://pubmed.ncbi.nlm.nih.gov/38234670/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,37223019,"Genes in loci genetically associated with polycystic ovary syndrome are dynamically expressed in human fetal gonadal, metabolic and brain tissues.",2023,10.3389/fendo.2023.1149473,https://pubmed.ncbi.nlm.nih.gov/37223019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,39219254,Association of candidate gene (INSR & THADA) polymorphism with polycystic ovary syndrome: meta-analysis and statistical power analysis.,2024,10.4274/jtgga.galenos.2024.2024-1-7,https://pubmed.ncbi.nlm.nih.gov/39219254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,41827959,Longitudinal Evaluation of Dysarthria Progression in Patients with Parkinson's Disease.,2026,10.3390/diagnostics16050683,https://pubmed.ncbi.nlm.nih.gov/41827959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,42551945,Optical genome mapping refines diagnosis of high-grade myeloid neoplasms through detection of MECOM rearrangements cryptic to conventional karyotype.,2026,10.1093/ajcp/aqag087,https://pubmed.ncbi.nlm.nih.gov/42551945/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,41970998,Identification of novel genomic variants in diabetic nephropathy patients using whole-exome sequencing: a pilot investigation.,2026,10.3389/fendo.2026.1798640,https://pubmed.ncbi.nlm.nih.gov/41970998/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,41283083,Resilience for Surgeons: Lessons from the Philosophy of the Bhagavad Gita.,2025,10.1007/s13193-024-02175-7,https://pubmed.ncbi.nlm.nih.gov/41283083/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,39499690,Registered report: The effectiveness of a Bhagavad Gita intervention to reduce psychological distress in homeless people-A randomised controlled trial.,2024,10.1371/journal.pone.0310795,https://pubmed.ncbi.nlm.nih.gov/39499690/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,42473585,Application Value of Multi-Gene Testing in the Evaluation of Benign and Malignant Thyroid Nodules.,2026,10.30498/ijb.2026.564985.4327,https://pubmed.ncbi.nlm.nih.gov/42473585/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,34341130,THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy.,2021,10.1136/jitc-2021-002443,https://pubmed.ncbi.nlm.nih.gov/34341130/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,40570327,Enhancing Quality of Life in Patients With Hypothyroidism Using a Scientific Yoga Module: Randomized Controlled Trial.,2025,10.2196/54078,https://pubmed.ncbi.nlm.nih.gov/40570327/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,34479926,Correction: THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy.,2021,10.1136/jitc-2021-002443orr1,https://pubmed.ncbi.nlm.nih.gov/34479926/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,37632631,"Population Pharmacokinetic Analysis of Follicle-Stimulating Hormone During Ovarian Stimulation: Relation with Weight, Prolactin and Gene Polymorphism in THADA and ADIPOQ.",2023,10.1007/s40262-023-01299-3,https://pubmed.ncbi.nlm.nih.gov/37632631/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,37982420,Evidence of positive selection of genetic variants associated with PCOS.,2023,10.1093/humrep/dead106,https://pubmed.ncbi.nlm.nih.gov/37982420/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,42515984,"Shared Genetic Architecture and Pleiotropic Loci Linking Endometriosis and Inflammatory Bowel Disease: An Integrative GWAS, Colocalization, and Mendelian Randomization Study.",2026,10.1155/bmri/8422273,https://pubmed.ncbi.nlm.nih.gov/42515984/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,40275442,"Malignancy Risk, Molecular Mutations, and Surgical Outcomes of Thyroid Nodules Classified as Atypia of Undetermined Significance in the Bethesda System: A Comprehensive Analysis.",2026,10.1111/cyt.13503,https://pubmed.ncbi.nlm.nih.gov/40275442/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,33421693,Relevance of Bhagavad Gita for healthcare workers amidst the COVID -19 crisis.,2021,10.1016/j.ajp.2020.102534,https://pubmed.ncbi.nlm.nih.gov/33421693/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,37342177,Scientific yoga module for hypothyroidism: A study protocol for tele-yoga RCT.,2023,10.1016/j.conctc.2023.101157,https://pubmed.ncbi.nlm.nih.gov/37342177/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,33678824,Building resilience in the COVID-19 era: Three paths in the Bhagavad Gita.,2020,10.4103/psychiatry.indianjpsychiatry_829_20,https://pubmed.ncbi.nlm.nih.gov/33678824/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THADA,ENSG00000115970,Unsafe,12955091,Identification of a gene rearranged by 2p21 aberrations in thyroid adenomas.,2003,10.1038/sj.onc.1206867,https://pubmed.ncbi.nlm.nih.gov/12955091/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP2,ENSG00000173451,Unsafe,41594224,The Whole Transcriptome Sequencing Profile of Serum-Derived Exosomes and Potential Pathophysiology of Age-Related Hearing Loss.,2026,10.3390/diagnostics16020248,https://pubmed.ncbi.nlm.nih.gov/41594224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP2,ENSG00000173451,Unsafe,38357906,Bone Marrow Mesenchymal Stem Cell-derived Exosomal microRNA-99b-5p Promotes Cell Growth of High Glucose-treated Human Umbilical Vein Endothelial Cells by Modulating THAP Domain Containing 2 Expression.,2024,10.2174/011574888x272011231128073104,https://pubmed.ncbi.nlm.nih.gov/38357906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP2,ENSG00000173451,Unsafe,38397108,Molecular Mechanism of Different Rooting Capacity between Two Clones of Taxodium hybrid 'Zhongshanshan'.,2024,10.3390/ijms25042427,https://pubmed.ncbi.nlm.nih.gov/38397108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP2,ENSG00000173451,Unsafe,23778488,MicroRNA 100: a context dependent miRNA in prostate cancer.,2013,10.6061/clinics/2013(06)12,https://pubmed.ncbi.nlm.nih.gov/23778488/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP2,ENSG00000173451,Unsafe,20926767,Late-gestational systemic hypoxia leads to a similar early gene response in mouse placenta and developing brain.,2010,10.1152/ajpregu.00697.2009,https://pubmed.ncbi.nlm.nih.gov/20926767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP2,ENSG00000173451,Unsafe,25493074,"The involvement of miR-100 in bladder urothelial carcinogenesis changing the expression levels of mRNA and proteins of genes related to cell proliferation, survival, apoptosis and chromosomal stability.",2014,10.1186/s12935-014-0119-3,https://pubmed.ncbi.nlm.nih.gov/25493074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP2,ENSG00000173451,Unsafe,19372056,"Change in expression of miR-let7c, miR-100, and miR-218 from high grade localized prostate cancer to metastasis.",2011,10.1016/j.urolonc.2009.02.002,https://pubmed.ncbi.nlm.nih.gov/19372056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP6,ENSG00000174796,Unsafe,42565575,[Effects of &lt;i&gt;Thap6&lt;/i&gt; gene knockout on emotional and social behaviors in mice].,2026,10.11817/j.issn.1672-7347.2026.260005,https://pubmed.ncbi.nlm.nih.gov/42565575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP6,ENSG00000174796,Unsafe,41165415,Spatiotemporal Patterns of Gene Expression Associated With Mating Stimuli in the Brain of Female Guppies.,2025,10.1111/gbb.70035,https://pubmed.ncbi.nlm.nih.gov/41165415/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP6,ENSG00000174796,Unsafe,26117544,Redefining the transcriptional regulatory dynamics of classically and alternatively activated macrophages by deepCAGE transcriptomics.,2015,10.1093/nar/gkv646,https://pubmed.ncbi.nlm.nih.gov/26117544/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,41612596,Integrative Genomic Analysis Identifies THAP9 as a Human-Specific Regulator of Oligodendrocyte Differentiation.,2026,10.1111/jnc.70348,https://pubmed.ncbi.nlm.nih.gov/41612596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,40015502,A m6A writer RBM15 enhances the cell malignancy of osteosarcoma by mediating m6A modification of lncRNA THAP9-AS1.,2025,10.1016/j.yexcr.2025.114490,https://pubmed.ncbi.nlm.nih.gov/40015502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,40379722,A novel LncRNA risk model for disulfidptosis-related prognosis prediction and response to chemotherapy in acute myeloid leukemia.,2025,10.1038/s41598-025-01730-8,https://pubmed.ncbi.nlm.nih.gov/40379722/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,42148878,"Phase I Study of Rogocekib in Patients with Advanced, Relapsed, or Refractory Malignant Solid Tumors.",2026,10.1158/1078-0432.ccr-25-4896,https://pubmed.ncbi.nlm.nih.gov/42148878/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,40766329,Targeting PDCD4 in cancer and atrial fibrillation: mechanistic insights from integrated multi-omics and single-cell analysis.,2025,10.3389/fonc.2025.1593815,https://pubmed.ncbi.nlm.nih.gov/40766329/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,35893234,Pan-Cancer Analysis Reveals the Prognostic Potential of the THAP9/THAP9-AS1 Sense-Antisense Gene Pair in Human Cancers.,2022,10.3390/ncrna8040051,https://pubmed.ncbi.nlm.nih.gov/35893234/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,38292821,"Bioinformatic analysis of THAP9 transposase homolog: conserved regions, novel motifs.",2024,10.1016/j.crstbi.2023.100113,https://pubmed.ncbi.nlm.nih.gov/38292821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,38270621,THAP9-AS1 promotes nasopharyngeal carcinoma progression through targeted regulation of the miR-185-5p/SOX13 axis.,2024,10.1556/2060.2023.00232,https://pubmed.ncbi.nlm.nih.gov/38270621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,36170961,LncRNA THAP9-AS1 highly expressed in tissues of hepatocellular carcinoma and accelerates tumor cell proliferation.,2022,10.1016/j.clinre.2022.102025,https://pubmed.ncbi.nlm.nih.gov/36170961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,34691358,THAP9-AS1 Promotes Tumorigenesis and Reduces ROS Generation through the JAK2/STAT3 Signaling Pathway by Increasing SOCS3 Promoter Methylation in Osteosarcoma.,2021,10.1155/2021/5620475,https://pubmed.ncbi.nlm.nih.gov/34691358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,33854048,THAP9-AS1/miR-133b/SOX4 positive feedback loop facilitates the progression of esophageal squamous cell carcinoma.,2021,10.1038/s41419-021-03690-z,https://pubmed.ncbi.nlm.nih.gov/33854048/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,39839902,In silico analysis of lncRNA-miRNA-mRNA signatures related to Sorafenib effectiveness in liver cancer cells.,2025,10.3748/wjg.v31.i3.95207,https://pubmed.ncbi.nlm.nih.gov/39839902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,34273804,LncRNA THAP9-AS1 accelerates cell growth of esophageal squamous cell carcinoma through sponging miR-335-5p to regulate SGMS2.,2021,10.1016/j.prp.2021.153526,https://pubmed.ncbi.nlm.nih.gov/34273804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,34288157,The role of long noncoding RNA THAP9-AS1 in the osteogenic differentiation of dental pulp stem cells via the miR-652-3p/VEGFA axis.,2021,10.1111/eos.12790,https://pubmed.ncbi.nlm.nih.gov/34288157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,38414024,Bioinformatic analysis and experimental validation of cuproptosis-related LncRNA as a novel biomarker for prognosis and immunotherapy of oral squamous cell carcinoma.,2024,10.1186/s41065-024-00311-5,https://pubmed.ncbi.nlm.nih.gov/38414024/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,33344646,Long Noncoding RNA THAP9-AS1 and TSPOAP1-AS1 Provide Potential Diagnostic Signatures for Pediatric Septic Shock.,2020,10.1155/2020/7170464,https://pubmed.ncbi.nlm.nih.gov/33344646/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,37304952,Genome-wide detection of m6A-associated SNPs in atrial fibrillation pathogenesis.,2023,10.3389/fcvm.2023.1152851,https://pubmed.ncbi.nlm.nih.gov/37304952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,31831555,lncRNA THAP9-AS1 Promotes Pancreatic Ductal Adenocarcinoma Growth and Leads to a Poor Clinical Outcome via Sponging miR-484 and Interacting with YAP.,2020,10.1158/1078-0432.ccr-19-0674,https://pubmed.ncbi.nlm.nih.gov/31831555/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,36597408,Identification and comparison of m6A modifications in glioblastoma non-coding RNAs with MeRIP-seq and Nanopore dRNA-seq.,2023,10.1080/15592294.2022.2163365,https://pubmed.ncbi.nlm.nih.gov/36597408/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,32021238,Long noncoding RNA THAP9-AS1 is induced by Helicobacter pylori and promotes cell growth and migration of gastric cancer.,2019,10.2147/ott.s201832,https://pubmed.ncbi.nlm.nih.gov/32021238/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
THAP9,ENSG00000168152,Unsafe,33102573,Construction and Analysis of lncRNA-Mediated ceRNA Network in Nasopharyngeal Carcinoma Based on Weighted Correlation Network Analysis.,2020,10.1155/2020/1468980,https://pubmed.ncbi.nlm.nih.gov/33102573/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,42022037,Topoisomerase II binding protein 1-interacting checkpoint and replication regulator promotes lung adenocarcinoma proliferation by regulating myelocytomatosis oncogene signaling pathway.,2026,10.25259/cytojournal_24_2025,https://pubmed.ncbi.nlm.nih.gov/42022037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,41445727,Multiomics analysis demonstrated that TOPBP1 interacting checkpoint and Replication Regulator may serve as an immune-related biomarker indicative of poor prognosis in lung adenocarcinoma.,2025,10.3389/fimmu.2025.1740279,https://pubmed.ncbi.nlm.nih.gov/41445727/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,41105363,Deciphering TICRR's oncogenic landscape in pancreatic adenocarcinoma: molecular insights and clinical implications.,2025,10.1007/s12672-025-03803-6,https://pubmed.ncbi.nlm.nih.gov/41105363/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,39246575,TICRR Overexpression Enhances Disease Aggressiveness and Immune Infiltration of Cutaneous Melanoma.,2024,10.2147/pgpm.s469972,https://pubmed.ncbi.nlm.nih.gov/39246575/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,40319014,Selective interactions at pre-replication complexes categorize baseline and dormant origins.,2025,10.1038/s41467-025-59509-4,https://pubmed.ncbi.nlm.nih.gov/40319014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,38968480,TICRR as a potential prognostic biomarker for lung adenocarcinoma: A comprehensive analysis using TCGA database.,2024,10.1097/md.0000000000038660,https://pubmed.ncbi.nlm.nih.gov/38968480/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,38152367,"TICRR serves as a prognostic biomarker in lung adenocarcinoma with implications in RNA epigenetic modification, DDR pathway, and RNA metabolism.",2023,10.3389/fonc.2023.1274439,https://pubmed.ncbi.nlm.nih.gov/38152367/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,37266876,Comprehensive Analysis of TICRR in Hepatocellular Carcinoma Based on Bioinformatics Analysis.,2024,10.1007/s10528-023-10378-w,https://pubmed.ncbi.nlm.nih.gov/37266876/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,40624716,Cell cycle-dependent TICRR/TRESLIN and MTBP chromatin binding mechanisms and patterns.,2025,10.1186/s13059-025-03665-9,https://pubmed.ncbi.nlm.nih.gov/40624716/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,36213689,ncRNAs-mediated high expression of TICRR promotes tumor cell proliferation and migration and is correlated with poor prognosis and tumor immune infiltration of hepatocellular carcinoma.,2022,10.1016/j.omtn.2022.09.007,https://pubmed.ncbi.nlm.nih.gov/36213689/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,41301931,TIM-3 Promotes Proliferation of Acute Myeloid Leukemia Blasts.,2025,10.3390/biomedicines13112841,https://pubmed.ncbi.nlm.nih.gov/41301931/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,41189590,Mendelian Randomization and Bioinformatics Analysis Reveal the Potential Protective Role of Metformin in Primary Liver Cancer.,2025,10.1002/fsn3.71156,https://pubmed.ncbi.nlm.nih.gov/41189590/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,35419294,A Cell Cycle-Related 13-mRNA Signature to Predict Prognosis in Hepatocellular Carcinoma.,2022,10.3389/fonc.2022.760190,https://pubmed.ncbi.nlm.nih.gov/35419294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,33505430,Increased Expression of TICRR Predicts Poor Clinical Outcomes: A Potential Therapeutic Target for Papillary Renal Cell Carcinoma.,2020,10.3389/fgene.2020.605378,https://pubmed.ncbi.nlm.nih.gov/33505430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,35091422,Refining the domain architecture model of the replication origin firing factor Treslin/TICRR.,2022,10.26508/lsa.202101088,https://pubmed.ncbi.nlm.nih.gov/35091422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,34534348,The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase.,2021,10.1093/nar/gkab805,https://pubmed.ncbi.nlm.nih.gov/34534348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,36311753,Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm.,2022,10.3389/fimmu.2022.1016683,https://pubmed.ncbi.nlm.nih.gov/36311753/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,31275851,TICRR Contributes to Tumorigenesis Through Accelerating DNA Replication in Cancers.,2019,10.3389/fonc.2019.00516,https://pubmed.ncbi.nlm.nih.gov/31275851/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,33495413,Overexpression of TICRR and PPIF confer poor prognosis in endometrial cancer identified by gene co-expression network analysis.,2021,10.18632/aging.202417,https://pubmed.ncbi.nlm.nih.gov/33495413/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,34699733,The role of DDK and Treslin-MTBP in coordinating replication licensing and pre-initiation complex formation.,2021,10.1098/rsob.210121,https://pubmed.ncbi.nlm.nih.gov/34699733/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,34008756,Prognostic implications of immune-related eight-gene signature in pediatric brain tumors.,2021,10.1590/1414-431x2020e10612,https://pubmed.ncbi.nlm.nih.gov/34008756/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,26238040,Functional analysis of the nasopharyngeal carcinoma primary tumor‑associated gene interaction network.,2015,10.3892/mmr.2015.4090,https://pubmed.ncbi.nlm.nih.gov/26238040/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TICRR,ENSG00000140534,Unsafe,24825563,Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease.,2014,10.1165/rcmb.2014-0135oc,https://pubmed.ncbi.nlm.nih.gov/24825563/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIGD7,ENSG00000140993,Unsafe,41521457,Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages.,2026,10.1002/advs.202516704,https://pubmed.ncbi.nlm.nih.gov/41521457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIGD7,ENSG00000140993,Unsafe,38618725,Exploration of Diagnostic Markers Associated with Inflammation in Chronic Kidney Disease Based on WGCNA and Machine Learning.,2024,10.1615/critrevimmunol.2024051277,https://pubmed.ncbi.nlm.nih.gov/38618725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIGD7,ENSG00000140993,Unsafe,36265781,A more novel and robust gene signature predicts outcome in patients with esophageal squamous cell carcinoma.,2022,10.1016/j.clinre.2022.102033,https://pubmed.ncbi.nlm.nih.gov/36265781/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIGD7,ENSG00000140993,Unsafe,15487591,"Isolation and characterization of a Jerky and JRK/JH8 like gene, tigger transposable element derived 7, TIGD7.",2004,10.1023/b:bigi.0000034428.95802.35,https://pubmed.ncbi.nlm.nih.gov/15487591/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIGD7,ENSG00000140993,Unsafe,21423737,Changes in whole blood gene expression in obese subjects with type 2 diabetes following bariatric surgery: a pilot study.,2011,10.1371/journal.pone.0016729,https://pubmed.ncbi.nlm.nih.gov/21423737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIGD7,ENSG00000140993,Unsafe,23289938,Genomic signatures of a global fitness index in a multi-ethnic cohort of women.,2013,10.1111/ahg.12006,https://pubmed.ncbi.nlm.nih.gov/23289938/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,42905753,A macrophage-targeted TIMD4 Peptide-Nanoparticle attenuates colitis symptoms and monocyte recruitment in a mouse model.,2026,10.1371/journal.pbio.3004056,https://pubmed.ncbi.nlm.nih.gov/42905753/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,40929246,Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction-associated steatohepatitis.,2025,10.1126/scitranslmed.adv2106,https://pubmed.ncbi.nlm.nih.gov/40929246/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,42735472,Timd4&lt;sup&gt;+&lt;/sup&gt; cardiac resident macrophages promote neutrophil chemotaxis and exacerbate sepsis-associated myocardial injury.,2026,10.1016/j.intimp.2026.117381,https://pubmed.ncbi.nlm.nih.gov/42735472/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,41136987,Epigenetic reprogramming of dendritic cells by DNMT1 inhibition attenuates Th2 skewing in allergic airway inflammation.,2025,10.1186/s12964-025-02467-7,https://pubmed.ncbi.nlm.nih.gov/41136987/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,42841477,Heterogeneity and ontogeny of mouse thymic macrophages reveal a requirement for &lt;i&gt;Csf1r&lt;/i&gt;-expressing myeloid cells during early T cell development.,2026,10.7554/elife.109219,https://pubmed.ncbi.nlm.nih.gov/42841477/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,41563642,Infiltration of TIM4-positive intratumoral macrophages serves as an adverse prognostic factor in breast cancer.,2026,10.1007/s12282-026-01825-8,https://pubmed.ncbi.nlm.nih.gov/41563642/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,42209436,Integrated multi-omics strategies for identifying novel therapies in psoriasis.,2026,10.1093/bioinformatics/btag347,https://pubmed.ncbi.nlm.nih.gov/42209436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,41639779,Elevated serum TIM4 is associated with disease severity and serves as a potential predictive biomarker in chronic hepatitis B.,2026,10.1186/s12879-026-12709-9,https://pubmed.ncbi.nlm.nih.gov/41639779/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,42118107,Cellular composition of tissue-resident monocyte-lineage cells reveals transcriptional heterogeneity during inflammatory arthritis.,2026,10.1093/jimmun/vkag077,https://pubmed.ncbi.nlm.nih.gov/42118107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,41469584,Different plasma exosome isolation methods generated distinct microRNA and protein profiles in healthy controls and patients with advanced prostate and lung cancer.,2025,10.1186/s12885-025-15492-z,https://pubmed.ncbi.nlm.nih.gov/41469584/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,41483833,From Tim4 to ischemic stroke: a mitochondrial pathway driving microglial M1 polarization.,2026,10.1016/j.brainres.2025.150140,https://pubmed.ncbi.nlm.nih.gov/41483833/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,42048131,Mesenteric macrophage-monocyte circuit controls systemic inflammation during enteric bacterial infection.,2026,10.1084/jem.20251492,https://pubmed.ncbi.nlm.nih.gov/42048131/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,41362741,Targeting Myeloid FoxO1 Ameliorates Sepsis-induced Intestinal Injury by Modulating Tim4&lt;sup&gt;+&lt;/sup&gt; Macrophage Glycolysis.,2026,10.7150/ijbs.119052,https://pubmed.ncbi.nlm.nih.gov/41362741/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,42066239,Magnetic Graphene for High-Performance Isolation of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes via Ca&lt;sup&gt;2+&lt;/sup&gt;-Dependent Reversible Recognition.,2026,10.1021/acsnano.6c02520,https://pubmed.ncbi.nlm.nih.gov/42066239/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,38418808,Tim4 deficiency reduces CD301b+ macrophage and aggravates periodontitis bone loss.,2024,10.1038/s41368-023-00270-z,https://pubmed.ncbi.nlm.nih.gov/38418808/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,40606633,TIM4+macrophages suppress the proinflammatory response to maintain the chronic alveolar echinococcosis infection.,2025,10.3389/fcimb.2025.1600686,https://pubmed.ncbi.nlm.nih.gov/40606633/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,40576208,A Pan-Cancer Study of Tumour-Associated Efferocytosis Core Genes and Preliminary Exploration of TIMD4 in Renal Cell Carcinoma.,2025,10.1111/jcmm.70671,https://pubmed.ncbi.nlm.nih.gov/40576208/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,41875622,Multi-omic and functional analyses identified an endoplasmic reticulum stress-driven TIMD4⁺ IL1β⁺ macrophage subpopulation contributes to osteoarthritis progression.,2026,10.1016/j.prp.2026.156442,https://pubmed.ncbi.nlm.nih.gov/41875622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,40621694,Monocyte-Derived Macrophages-Synovial Fibroblasts Crosstalk Unravels Oncostatin Signaling Network as a Driver of Synovitis in Osteoarthritis.,2026,10.1002/art.43299,https://pubmed.ncbi.nlm.nih.gov/40621694/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,42536710,Two differentiation pathways generate large peritoneal macrophages with one replenishing mesothelial border macrophages.,2026,10.1126/sciimmunol.aeg8653,https://pubmed.ncbi.nlm.nih.gov/42536710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,42856794,Targeting TREM2&lt;sup&gt;+&lt;/sup&gt; and TIMD4&lt;sup&gt;+&lt;/sup&gt; Macrophages Reprograms the Tumor Microenvironment and Enhances PD-1 Blockade Efficacy in Intrahepatic Cholangiocarcinoma.,2026,10.34133/cancomm.0056,https://pubmed.ncbi.nlm.nih.gov/42856794/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,41162642,Cancer suppresses mitochondrial chaperone activity in macrophages to drive immune evasion.,2025,10.1038/s41590-025-02324-2,https://pubmed.ncbi.nlm.nih.gov/41162642/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,39695662,Dust mite antigens endow dendritic cells with the capacity to induce a Th2 response by regulating their methylation profiles.,2024,10.1186/s12964-024-01986-z,https://pubmed.ncbi.nlm.nih.gov/39695662/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,42305533,Multi-layered functional genomics prioritizes candidate effectors and regulatory mechanisms of ankylosing spondylitis.,2026,10.3389/fimmu.2026.1859310,https://pubmed.ncbi.nlm.nih.gov/42305533/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,40604335,CD81 Aggravates Ovarian Cancer Progression via p-Cresyl Sulfate-Mediated Mitophagy in Tim4&lt;sup&gt;+&lt;/sup&gt; Tumour-Associated Macrophages.,2025,10.1111/jcmm.70701,https://pubmed.ncbi.nlm.nih.gov/40604335/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIMD4,ENSG00000145850,Unsafe,18082433,TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.,2007,10.1016/j.immuni.2007.11.011,https://pubmed.ncbi.nlm.nih.gov/18082433/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,41291151,TIPIN coordinates ATM-dependent checkpoint and NF-κB signaling to counteract DNA replication damage from topoisomerase inhibition.,2025,10.1038/s42003-025-09084-7,https://pubmed.ncbi.nlm.nih.gov/41291151/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,41717160,Progesterone Enhances the Sensitivity of Ovarian Cancer Cells to Poly (ADP-Ribose) Polymerase (PARP) Inhibitors by Suggesting a Role for Transcription-Replication Conflict-Related Pathways: An In Vitro Study.,2026,10.7759/cureus.101806,https://pubmed.ncbi.nlm.nih.gov/41717160/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,38487270,Timeless-Tipin interactions with MCM and RPA mediate DNA replication stress response.,2024,10.3389/fcell.2024.1346534,https://pubmed.ncbi.nlm.nih.gov/38487270/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,39972127,Mechanism for local attenuation of DNA replication at double-strand breaks.,2025,10.1038/s41586-024-08557-9,https://pubmed.ncbi.nlm.nih.gov/39972127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,35082931,Integrated Bioinformatic Analysis Identifies TIPIN as a Prognostic Biomarker in Hepatocellular Carcinoma.,2022,10.1155/2022/5764592,https://pubmed.ncbi.nlm.nih.gov/35082931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,38509368,Transcription-replication conflicts underlie sensitivity to PARP inhibitors.,2024,10.1038/s41586-024-07217-2,https://pubmed.ncbi.nlm.nih.gov/38509368/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,39003404,The shared mechanism and potential diagnostic markers for premature ovarian failure and dry eye disease.,2024,10.1038/s41598-024-67284-3,https://pubmed.ncbi.nlm.nih.gov/39003404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,32499870,Knock-down of the TIM/TIPIN complex promotes apoptosis in melanoma cells.,2020,10.18632/oncotarget.27572,https://pubmed.ncbi.nlm.nih.gov/32499870/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,34269473,TIMELESS-TIPIN and UBXN-3 promote replisome disassembly during DNA replication termination in Caenorhabditis elegans.,2021,10.15252/embj.2021108053,https://pubmed.ncbi.nlm.nih.gov/34269473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,34694004,Structure of a human replisome shows the organisation and interactions of a DNA replication machine.,2021,10.15252/embj.2021108819,https://pubmed.ncbi.nlm.nih.gov/34694004/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,34934449,Identification of potential key genes and functional role of CENPF in osteosarcoma using bioinformatics and experimental analysis.,2022,10.3892/etm.2021.11003,https://pubmed.ncbi.nlm.nih.gov/34934449/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,39236719,Mechanisms controlling replication fork stalling and collapse at topoisomerase 1 cleavage complexes.,2024,10.1016/j.molcel.2024.08.004,https://pubmed.ncbi.nlm.nih.gov/39236719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,33816217,Construction of Gene Modules and Analysis of Prognostic Biomarkers for Cervical Cancer by Weighted Gene Co-Expression Network Analysis.,2021,10.3389/fonc.2021.542063,https://pubmed.ncbi.nlm.nih.gov/33816217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,36997515,Excessive reactive oxygen species induce transcription-dependent replication stress.,2023,10.1038/s41467-023-37341-y,https://pubmed.ncbi.nlm.nih.gov/36997515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,35048968,TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination.,2022,10.1093/nar/gkac011,https://pubmed.ncbi.nlm.nih.gov/35048968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,38466804,The Novel ATR Inhibitor M1774 Induces Replication Protein Overexpression and Broad Synergy with DNA-targeted Anticancer Drugs.,2024,10.1158/1535-7163.mct-23-0402,https://pubmed.ncbi.nlm.nih.gov/38466804/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,35661926,Essential role of CK2α for the interaction and stability of replication fork factors during DNA synthesis and activation of the S-phase checkpoint.,2022,10.1007/s00018-022-04374-3,https://pubmed.ncbi.nlm.nih.gov/35661926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,35585232,Fast and efficient DNA replication with purified human proteins.,2022,10.1038/s41586-022-04759-1,https://pubmed.ncbi.nlm.nih.gov/35585232/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,36267209,Escape from G1 arrest during acute MEK inhibition drives the acquisition of drug resistance.,2022,10.1093/narcan/zcac032,https://pubmed.ncbi.nlm.nih.gov/36267209/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,26004086,TIPIN depletion leads to apoptosis in breast cancer cells.,2015,10.1016/j.molonc.2015.04.010,https://pubmed.ncbi.nlm.nih.gov/26004086/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,34689170,Germline polymorphisms in genes maintaining the replication fork predict the efficacy of oxaliplatin and irinotecan in patients with metastatic colorectal cancer.,2022,10.1038/s41416-021-01592-7,https://pubmed.ncbi.nlm.nih.gov/34689170/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,32345670,The Clinical Relevance of Frequent Germline Genetic Variants Detected by Targeted Sequencing in Patients With Rectal Adenocarcinoma (READ).,2020,10.21873/cgp.20189,https://pubmed.ncbi.nlm.nih.gov/32345670/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,33127907,SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks.,2020,10.1038/s41467-020-19162-5,https://pubmed.ncbi.nlm.nih.gov/33127907/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,33166393,"Separable functions of Tof1/Timeless in intra-S-checkpoint signalling, replisome stability and DNA topological stress.",2020,10.1093/nar/gkaa963,https://pubmed.ncbi.nlm.nih.gov/33166393/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,34608864,DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks.,2021,10.7554/elife.70787,https://pubmed.ncbi.nlm.nih.gov/34608864/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,31805522,Fork pausing complex engages topoisomerases at the replisome.,2020,10.1101/gad.331868.119,https://pubmed.ncbi.nlm.nih.gov/31805522/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,27492458,Disruption of clock gene expression in human colorectal liver metastases.,2016,10.1007/s13277-016-5231-7,https://pubmed.ncbi.nlm.nih.gov/27492458/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,17296725,The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement.,2007,10.1128/mcb.02190-06,https://pubmed.ncbi.nlm.nih.gov/17296725/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,17141802,Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors.,2007,10.1016/j.jmb.2006.10.097,https://pubmed.ncbi.nlm.nih.gov/17141802/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIPIN,ENSG00000075131,Unsafe,23325691,Timeless-dependent DNA replication-coupled recombination promotes Kaposi's Sarcoma-associated herpesvirus episome maintenance and terminal repeat stability.,2013,10.1128/jvi.02211-12,https://pubmed.ncbi.nlm.nih.gov/23325691/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,42698655,Nuclear localization of Toll/interleukin-1 receptor domain-containing adaptor protein reveals a previously unrecognized role in hepatic stellate cell activation.,2026,10.3389/fimmu.2026.1870084,https://pubmed.ncbi.nlm.nih.gov/42698655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,42614271,Toll/IL-1 receptor domain-containing adaptor protein plays a crucial role in macrophage-mediated hepatic stellate cell activation in alcoholic liver disease.,2026,10.3389/fcell.2026.1883301,https://pubmed.ncbi.nlm.nih.gov/42614271/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,42310187,A Sulfonamide-Based Compound DRZ-V Enhances Wound Repair via Macrophage-Mediated Responses Associated with TIRAP-NF-κB Signaling.,2026,10.1007/s11095-026-04131-2,https://pubmed.ncbi.nlm.nih.gov/42310187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,42552630,MyD88-Family Adaptors: Compartmentalised Signalling and Non-Immune Functions.,2026,10.1111/imm.70184,https://pubmed.ncbi.nlm.nih.gov/42552630/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,42778610,TRAM promotes Toll-like-receptor-free myddosome signal transduction.,2026,10.1038/s41586-026-11052-y,https://pubmed.ncbi.nlm.nih.gov/42778610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,42565646,"Maternal High Fat Diet and Acute Viral Mimic Exposure Impact Placental Inflammation, Lipid Peroxidation and Cellular Proliferation-to-Death Ratio Across Mouse Pregnancy.",2026,10.1111/aji.70290,https://pubmed.ncbi.nlm.nih.gov/42565646/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,42858882,The lncRNA-mediated ceRNA network of Largemouth Bass contribute to immune regulation during LMBV Infection.,2026,10.1016/j.micpath.2026.108865,https://pubmed.ncbi.nlm.nih.gov/42858882/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,40975499,Inhibiting TIRAP-mediated inflammatory signaling: A promising therapeutic strategy against sepsis.,2025,10.1016/j.bcp.2025.117353,https://pubmed.ncbi.nlm.nih.gov/40975499/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,42510697,Integrative Bioinformatics Prioritizes the &lt;i&gt;TLR4&lt;/i&gt; Axis and Candidate Non-Starch Polysaccharides in Hyperuricemia-Associated Inflammation.,2026,10.3390/biology15141150,https://pubmed.ncbi.nlm.nih.gov/42510697/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,41159953,A novel TIRAP-MyD88 inhibitor blocks TLR7- and TLR8-induced type I IFN responses.,2025,10.1093/jimmun/vkaf258,https://pubmed.ncbi.nlm.nih.gov/41159953/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,41166992,"Corrigendum to ""A peptide derived from the core β-sheet region of TIRAP decoys TLR4 and reduces inflammatory and autoimmune symptoms in murine models"" [eBioMedicine 52 (2020) 102645].",2025,10.1016/j.ebiom.2025.105953,https://pubmed.ncbi.nlm.nih.gov/41166992/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,39781449,"Toll-like receptor adaptor protein TIRAP has specialized roles in signaling, metabolic control and leukocyte migration upon wounding in zebrafish larvae.",2025,10.7150/ijbs.101055,https://pubmed.ncbi.nlm.nih.gov/39781449/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,40033498,Revealing the Mechanism of Buzhong Yiqi Tang in Ameliorating Autoimmune Thyroiditis &lt;i&gt;via&lt;/i&gt; the Toll-like Receptor Pathway.,2026,10.2174/0113862073357259250214111143,https://pubmed.ncbi.nlm.nih.gov/40033498/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,41665962,IFN-γ-induced trained immunity enhances killing of priority pathogens in healthy and genetically vulnerable individuals.,2026,10.1172/jci.insight.195866,https://pubmed.ncbi.nlm.nih.gov/41665962/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,40979914,Inhibition of LOXL2 Suppresses Nasal Mucosal Inflammation and Remodeling in Allergic Rhinitis.,2025,10.2147/jaa.s535065,https://pubmed.ncbi.nlm.nih.gov/40979914/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,41897345,Systemic Effects of Oral Antibiotics in Mice: A Combined Physiological and Molecular Approach.,2026,10.3390/biom16030409,https://pubmed.ncbi.nlm.nih.gov/41897345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,42177796,RANKL inhibits macrophage proinflammatory Toll-like receptor 2 and 4 signaling and impairs killing of intracellular bacteria.,2026,10.1093/immhor/vlag023,https://pubmed.ncbi.nlm.nih.gov/42177796/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,41081077,The role of Toll-like receptors in liver regeneration after partial hepatectomy.,2025,10.5114/pg.2025.154724,https://pubmed.ncbi.nlm.nih.gov/41081077/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,42243884,Heterodimerization with signaling-inert TLR8b converts TLR8a from proviral to antiviral sensor in Ctenopharyngodon idella.,2026,10.1186/s12964-026-02982-1,https://pubmed.ncbi.nlm.nih.gov/42243884/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,39617791,Hypothermic oxygenated perfusion inhibits CLIP1-mediated TIRAP ubiquitination via TFPI2 to reduce ischemia‒reperfusion injury of the fatty liver.,2024,10.1038/s12276-024-01350-8,https://pubmed.ncbi.nlm.nih.gov/39617791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,42446204,The Dual Role of TLR2 in Breast Cancer: Implications for Therapeutic Targeting.,2026,10.1080/08820139.2026.2698759,https://pubmed.ncbi.nlm.nih.gov/42446204/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,42339729,Single-cell RNA sequencing reveals IgM &lt;sup&gt;+&lt;/sup&gt; B cell differentiation and protective responses after DNA vaccination and &lt;i&gt;Vibrio anguillarum&lt;/i&gt; challenge in flounder ( &lt;i&gt;Paralichthys olivaceus&lt;/i&gt;).,2026,10.24272/j.issn.2095-8137.2025.302,https://pubmed.ncbi.nlm.nih.gov/42339729/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,41319095,Development and Validation of a Prognostic Model for Lung Cancer Based on Machine Learning and Immune Microenvironment Analysis.,2025,10.1111/jcmm.70962,https://pubmed.ncbi.nlm.nih.gov/41319095/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,39631651,Dorzolamide intermediates with potential anti-inflammatory activity.,2025,10.1016/j.ejphar.2024.177160,https://pubmed.ncbi.nlm.nih.gov/39631651/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,40823350,A Chimeric Peptide Derived from a Bacterial Effector Protein Attenuates TLR-2/4-Mediated Production of Pro-Inflammatory Cytokines and Enhances the Cellular Availability of Gentamicin.,2025,10.2147/jir.s526902,https://pubmed.ncbi.nlm.nih.gov/40823350/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,41071380,Development and validation of a leukemia prognostic model through single-cell RNA sequencing and machine learning approaches.,2025,10.1007/s12672-025-03757-9,https://pubmed.ncbi.nlm.nih.gov/41071380/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,40535818,"Pyroptosis-Related Gene Signatures Enable Robustly Diagnosis, Prognosis and Immune Responses Prediction in Uterine Corpus Endometrial Carcinoma.",2025,10.7150/jca.104826,https://pubmed.ncbi.nlm.nih.gov/40535818/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,40433385,"SARM1: a key multifaceted component in immunoregulation, inflammation and neurodegeneration.",2025,10.3389/fimmu.2025.1521364,https://pubmed.ncbi.nlm.nih.gov/40433385/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,36888688,Tirap controls Mycobacterium tuberculosis phagosomal acidification.,2023,10.1371/journal.ppat.1011192,https://pubmed.ncbi.nlm.nih.gov/36888688/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,40711583,MyD88 polymerization and association to cellular membranes in a yeast heterologous model.,2025,10.1007/s00018-025-05827-1,https://pubmed.ncbi.nlm.nih.gov/40711583/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,35447474,Microbiota-dependent TLR2 signaling reduces silver nanoparticle toxicity to zebrafish larvae.,2022,10.1016/j.ecoenv.2022.113522,https://pubmed.ncbi.nlm.nih.gov/35447474/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,38790160,"The Immune Microenvironment Landscape of Pituitary NeuroEndocrine Tumors, a Transcriptomic Approach.",2024,10.3390/genes15050531,https://pubmed.ncbi.nlm.nih.gov/38790160/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,42098854,A pyroptosis-related molecular signature stratifies prognosis and highlights GSDMB-mediated malignancy in intrahepatic cholangiocarcinoma.,2026,10.1186/s13062-026-00824-1,https://pubmed.ncbi.nlm.nih.gov/42098854/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TIRAP,ENSG00000150455,Unsafe,38416868,o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2.,2024,10.1080/14756366.2024.2313055,https://pubmed.ncbi.nlm.nih.gov/38416868/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,42802226,Transketolase-like 1 potentiates PD-1 blockade in hepatocellular carcinoma by glycolysis to prime dendritic cell lactylation.,2026,10.1038/s41392-026-02875-2,https://pubmed.ncbi.nlm.nih.gov/42802226/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,42533116,TKTL1 mediates metabolic adaptation and stress resistance in pancreatic cancer cells under nutrient-deprived conditions.,2026,10.1038/s41388-026-03913-7,https://pubmed.ncbi.nlm.nih.gov/42533116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,40783353,Erratum to TKTL1: a new candidate gene in non-obstructive azoospermia Reproductive BioMedicine Online 51/3 (2025) 104895.,2025,10.1016/j.rbmo.2025.105185,https://pubmed.ncbi.nlm.nih.gov/40783353/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,40720083,Apo10 and TKTL1 in blood macrophages as non-invasive biomarkers for early detection of cervical cancer.,2025,10.1007/s13402-025-01092-3,https://pubmed.ncbi.nlm.nih.gov/40720083/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,42471432,Single cell and bulk transcriptomics reveal metabolic reprogramming biomarker signatures during extracorporeal membrane oxygenation for cardiogenic shock.,2026,10.1038/s41598-026-62728-4,https://pubmed.ncbi.nlm.nih.gov/42471432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,40680550,TKTL1: a new candidate gene in non-obstructive azoospermia.,2025,10.1016/j.rbmo.2025.104895,https://pubmed.ncbi.nlm.nih.gov/40680550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,42100784,Expanding the phenotypic spectrum of Xq28 duplication involving MECP2: a familial case report.,2026,10.3389/fpsyt.2026.1810637,https://pubmed.ncbi.nlm.nih.gov/42100784/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,41203358,Role of transketolase-like1 in human cortical neurogenesis.,2025,10.1016/bs.mie.2025.06.039,https://pubmed.ncbi.nlm.nih.gov/41203358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,42381053,Machine learning reveals X chromosome transcriptional signatures that classify systemic lupus erythematosus in females.,2026,10.1186/s41927-026-00669-1,https://pubmed.ncbi.nlm.nih.gov/42381053/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,41766871,Identification and validation of prognostic genes related to glycolysis and M2 macrophage in hepatocellular carcinoma: an integrated analysis of bulk RNA sequencing and single-cell RNA sequencing.,2026,10.3389/fimmu.2026.1710411,https://pubmed.ncbi.nlm.nih.gov/41766871/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,38675412,"Neurogenesis-Associated Protein, a Potential Prognostic Biomarker in Anti-PD-1 Based Kidney Renal Clear Cell Carcinoma Patient Therapeutics.",2024,10.3390/ph17040451,https://pubmed.ncbi.nlm.nih.gov/38675412/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,41370394,Evaluating the effects of archaic protein-altering variants in living human adults.,2025,10.1126/sciadv.ads5703,https://pubmed.ncbi.nlm.nih.gov/41370394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,41613799,Detection of Prostate Carcinoma in an Asymptomatic Individual Initiated by an Immunological Biopsy-A Case Report.,2026,10.32604/or.2025.068555,https://pubmed.ncbi.nlm.nih.gov/41613799/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,40076035,Single-Cell RNA Sequencing Reveals an Atlas of Meihua Pig Testis Cells.,2025,10.3390/ani15050752,https://pubmed.ncbi.nlm.nih.gov/40076035/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,39644404,Apo10 and TKTL1 in blood macrophages as potential biomarkers for early diagnosis of operable breast cancer.,2025,10.1007/s10549-024-07569-3,https://pubmed.ncbi.nlm.nih.gov/39644404/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,41020695,CDH1 Orchestrates Anabolic Events to Promote Cell Cycle Initiation.,2025,10.1002/advs.202507584,https://pubmed.ncbi.nlm.nih.gov/41020695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,38073178,"Genome sequencing of Pakistani families with male infertility identifies deleterious genotypes in SPAG6, CCDC9, TKTL1, TUBA3C, and M1AP.",2025,10.1111/andr.13570,https://pubmed.ncbi.nlm.nih.gov/38073178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,39311634,Molecular Characteristics and Expression of TKTL1 in Germ Cells: Implications for Nontumour Cell Research.,2024,10.1111/rda.14723,https://pubmed.ncbi.nlm.nih.gov/39311634/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,36009359,Epitope Detection in Monocytes (EDIM) As a New Method of Liquid Biopsy in Pediatric Rhabdomyosarcoma.,2022,10.3390/biomedicines10081812,https://pubmed.ncbi.nlm.nih.gov/36009359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,37341056,Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer.,2023,10.1002/1878-0261.13474,https://pubmed.ncbi.nlm.nih.gov/37341056/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,41639165,Machine learning-based prognostic model of stemness and angiogenesis-related genes for predicting prognosis and immune infiltration in patients with HCC.,2026,10.1038/s41598-026-38379-w,https://pubmed.ncbi.nlm.nih.gov/41639165/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,37914307,Utility of peripheral blood macrophage factor Apo10 and TKTL1 as markers in distinguishing malignant from benign lung nodules: a protocol for a prospective cohort study in Southern China.,2023,10.1136/bmjopen-2023-076573,https://pubmed.ncbi.nlm.nih.gov/37914307/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,37378867,Apo10 and TKTL1 in blood macrophages as biomarkers for differentiating lung cancer from benign lung lesions: a comparative study with conventional biomarkers.,2023,10.1007/s13402-023-00838-1,https://pubmed.ncbi.nlm.nih.gov/37378867/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,39096475,Development and Validation of a Carbohydrate Metabolism-Related Model for Predicting Prognosis and Immune Landscape in Hepatocellular Carcinoma Patients.,2024,10.1007/s11596-024-2886-y,https://pubmed.ncbi.nlm.nih.gov/39096475/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,35864157,Epitope detection in monocytes (EDIM) for liquid biopsy including identification of GD2 in childhood neuroblastoma-a pilot study.,2022,10.1038/s41416-022-01855-x,https://pubmed.ncbi.nlm.nih.gov/35864157/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,38455402,Regulating TKT activity inhibits proliferation of human acute lymphoblastic leukemia cells.,2024,10.21203/rs.3.rs-3326583/v1,https://pubmed.ncbi.nlm.nih.gov/38455402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,36362375,Identification of Hypoxia-Related Prognostic Signature and Competing Endogenous RNA Regulatory Axes in Hepatocellular Carcinoma.,2022,10.3390/ijms232113590,https://pubmed.ncbi.nlm.nih.gov/36362375/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,37346076,Case Report: Early detection of lung carcinoid in an asymptomatic individual by blood-test initiated PET-CT imaging.,2023,10.3389/fonc.2023.1177237,https://pubmed.ncbi.nlm.nih.gov/37346076/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,36175412,Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals new therapeutic strategies.,2022,10.1038/s41467-022-33282-0,https://pubmed.ncbi.nlm.nih.gov/36175412/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,34938106,Hypoxia-Related Gene-Based Signature Can Evaluate the Tumor Immune Microenvironment and Predict the Prognosis of Colon Adenocarcinoma Patients.,2021,10.2147/ijgm.s343216,https://pubmed.ncbi.nlm.nih.gov/34938106/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,38145010,RNA Sequencing and Bioinformatics Analysis to Reveal Potential Biomarkers in Patients with Combined Allergic Rhinitis and Asthma Syndrome.,2023,10.2147/jir.s438758,https://pubmed.ncbi.nlm.nih.gov/38145010/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,36692643,Metabolic heterogeneity in early-stage lung adenocarcinoma revealed by RNA-seq and scRNA-seq.,2023,10.1007/s12094-023-03082-z,https://pubmed.ncbi.nlm.nih.gov/36692643/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,36074851,Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals.,2022,10.1126/science.abl6422,https://pubmed.ncbi.nlm.nih.gov/36074851/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,15991799,"Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer.",2005,,https://pubmed.ncbi.nlm.nih.gov/15991799/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TKTL1,ENSG00000007350,Unsafe,8838793,Molecular cloning of tissue-specific transcripts of a transketolase-related gene: implications for the evolution of new vertebrate genes.,1996,10.1006/geno.1996.0124,https://pubmed.ncbi.nlm.nih.gov/8838793/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLCD3B,ENSG00000149926,Unsafe,42365880,"The 24,25(OH)&lt;sub&gt;2&lt;/sub&gt;D&lt;sub&gt;3&lt;/sub&gt;-TLCD3B signaling complex and reproductive function in mice and men.",2026,10.1016/j.jsbmb.2026.107060,https://pubmed.ncbi.nlm.nih.gov/42365880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLCD3B,ENSG00000149926,Unsafe,42400802,Identifying genetics biomarkers in correlation with pathological and PSMA PET/CT characteristics in prostate cancer.,2026,10.1186/s13550-026-01471-3,https://pubmed.ncbi.nlm.nih.gov/42400802/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLCD3B,ENSG00000149926,Unsafe,41148797,Suppression of Cornea Stromal Fibrosis by Vitamin D.,2025,10.3390/cells14201583,https://pubmed.ncbi.nlm.nih.gov/41148797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLCD3B,ENSG00000149926,Unsafe,37466006,Ceramide compensation by ceramide synthases preserves retinal function and structure in a retinal dystrophy mouse model.,2023,10.1242/dmm.050168,https://pubmed.ncbi.nlm.nih.gov/37466006/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLCD3B,ENSG00000149926,Unsafe,34984324,16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis.,2022,10.1016/j.isci.2021.103551,https://pubmed.ncbi.nlm.nih.gov/34984324/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLCD3B,ENSG00000149926,Unsafe,35275174,AAV8-Mediated Gene Therapy Rescues Retinal Degeneration Phenotype in a Tlcd3b Knockout Mouse Model.,2022,10.1167/iovs.63.3.11,https://pubmed.ncbi.nlm.nih.gov/35275174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLCD3B,ENSG00000149926,Unsafe,37968726,Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein.,2023,10.1186/s13059-023-03092-8,https://pubmed.ncbi.nlm.nih.gov/37968726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLCD3B,ENSG00000149926,Unsafe,33077892,Ceramide synthase TLCD3B is a novel gene associated with human recessive retinal dystrophy.,2021,10.1038/s41436-020-01003-x,https://pubmed.ncbi.nlm.nih.gov/33077892/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLCD3B,ENSG00000149926,Unsafe,30010626,"Optimal bone fracture repair requires 24R,25-dihydroxyvitamin D3 and its effector molecule FAM57B2.",2018,10.1172/jci98093,https://pubmed.ncbi.nlm.nih.gov/30010626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLCD3B,ENSG00000149926,Unsafe,36595826,Establishment of a prognostic prediction system based on tumor microenvironment of pancreatic cancer.,2022,10.1097/md.0000000000032364,https://pubmed.ncbi.nlm.nih.gov/36595826/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLCD3B,ENSG00000149926,Unsafe,23275342,"Fam57b (family with sequence similarity 57, member B), a novel peroxisome proliferator-activated receptor γ target gene that regulates adipogenesis through ceramide synthesis.",2013,10.1074/jbc.m112.440792,https://pubmed.ncbi.nlm.nih.gov/23275342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLCD3B,ENSG00000149926,Unsafe,34745101,International Prognostic Index-Based Immune Prognostic Model for Diffuse Large B-Cell Lymphoma.,2021,10.3389/fimmu.2021.732006,https://pubmed.ncbi.nlm.nih.gov/34745101/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,42910041,Quercetin upregulates TLE4 to block the Wnt/β-catenin signaling pathway and inhibit cell migration and invasion of cervical cancer cells.,2026,10.3389/fphar.2026.1892382,https://pubmed.ncbi.nlm.nih.gov/42910041/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,40835866,A preliminary bioinformatic screen to identify SRI SMC2 PSIP1 TLE4 and MSX1 as potential diagnostic and prognostic markers of osteoarthritis.,2025,10.1038/s41598-025-13575-2,https://pubmed.ncbi.nlm.nih.gov/40835866/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,40816475,Long noncoding RNA HNF4A-AS1 upregulates TLE4 to inhibit hepatitis B virus replication.,2025,10.1016/j.virusres.2025.199616,https://pubmed.ncbi.nlm.nih.gov/40816475/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,42039706,XIAP Deficiency Impairs Colonic Tuft Cell Development and Predisposes to Crohn's Disease.,2026,10.1002/mco2.70745,https://pubmed.ncbi.nlm.nih.gov/42039706/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,42602988,Multi-omics dissection of FOXA1 reveals cancer-type-specific transcriptional networks and functional risk variants.,2026,10.1016/j.isci.2026.117064,https://pubmed.ncbi.nlm.nih.gov/42602988/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,41463075,Subtype-Independent Dysregulation of the Notch Signaling Pathway and Its miRNA Regulators in Breast Cancer.,2025,10.3390/biomedicines13123065,https://pubmed.ncbi.nlm.nih.gov/41463075/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,41810855,Overexpression of the transcriptional corepressor Tle1 enhances effector proliferation of CD8+ T cells during acute and chronic viral infections.,2026,10.1093/intimm/dxag001,https://pubmed.ncbi.nlm.nih.gov/41810855/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,40406521,&lt;i&gt;Helicobacter pylori&lt;/i&gt; induced miR-362-5p upregulation drives gastric cancer progression and links hepatocellular carcinoma through an exosome-dependent pathway.,2025,10.3389/fcimb.2025.1582131,https://pubmed.ncbi.nlm.nih.gov/40406521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,42071182,Single cell RNA sequencing reveals transitional states and signaling shifts in nephron progenitor cells of the late-gestation rhesus macaque kidney.,2026,10.1186/s12864-026-12908-3,https://pubmed.ncbi.nlm.nih.gov/42071182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,42192100,Epigenome-wide association study of psilocybin-induced methylome changes in alcohol use disorder.,2026,10.1038/s41398-026-03961-3,https://pubmed.ncbi.nlm.nih.gov/42192100/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,39006072,TLE4 downregulation identified by WGCNA and machine learning algorithm promotes papillary thyroid carcinoma progression via activating JAK/STAT pathway.,2024,10.7150/jca.95501,https://pubmed.ncbi.nlm.nih.gov/39006072/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,38368400,A simple and reliable method for claustrum localization across age in mice.,2024,10.1186/s13041-024-01082-w,https://pubmed.ncbi.nlm.nih.gov/38368400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,39315707,scMMO-atlas: a single cell multimodal omics atlas and portal for exploring fine cell heterogeneity and cell dynamics.,2025,10.1093/nar/gkae821,https://pubmed.ncbi.nlm.nih.gov/39315707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,40267082,Methylome and transcriptome analyses reveal HLA-DMB's contribution to periodontitis development.,2025,10.1371/journal.pone.0319055,https://pubmed.ncbi.nlm.nih.gov/40267082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,39838044,TLE4 is a repressor of the oncogenic activity of TLX3 in T-cell acute lymphoblastic leukemia.,2025,10.1038/s41375-025-02513-w,https://pubmed.ncbi.nlm.nih.gov/39838044/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,38791273,Sox10 Activity and the Timing of Schwann Cell Differentiation Are Controlled by a Tle4-Dependent Negative Feedback Loop.,2024,10.3390/ijms25105234,https://pubmed.ncbi.nlm.nih.gov/38791273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,37561632,Tle4 controls both developmental acquisition and early post-natal maturation of corticothalamic projection neuron identity.,2023,10.1016/j.celrep.2023.112957,https://pubmed.ncbi.nlm.nih.gov/37561632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,38600964,The impact of canonical Wnt transcriptional repressors TLE3 and TLE4 on postsynaptic transcription at the neuromuscular junction.,2024,10.3389/fnmol.2024.1360368,https://pubmed.ncbi.nlm.nih.gov/38600964/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,38714941,Characterization of sexual maturity-associated N6-methyladenosine in boar testes.,2024,10.1186/s12864-024-10343-w,https://pubmed.ncbi.nlm.nih.gov/38714941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,38710443,Neuroplasticity-related genes correlate with individual differences in distinct phases of oxycodone self-administration in male rats.,2024,10.1016/j.neuropharm.2024.109972,https://pubmed.ncbi.nlm.nih.gov/38710443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,36801171,TLE3 and TLE4-coordinated colonic macrophage-CD4+ T cell crosstalk maintains intestinal immune homeostasis.,2023,10.1016/j.mucimm.2022.12.005,https://pubmed.ncbi.nlm.nih.gov/36801171/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,40473764,Development of a prognostic model for chemotherapy response and identification of TNFAIP2 as a target in colorectal cancer.,2025,10.1038/s41598-025-05556-2,https://pubmed.ncbi.nlm.nih.gov/40473764/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,34211555,miR-302d Competitively Binding with the lncRNA-341 Targets TLE4 in the Process of SSC Generation.,2021,10.1155/2021/5546936,https://pubmed.ncbi.nlm.nih.gov/34211555/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,34438242,"Potential role of CMPK1, SLC29A1, and TLE4 polymorphisms in gemcitabine-based chemotherapy in HER2-negative metastatic breast cancer patients: pharmacogenetic study results from the prospective randomized phase II study of eribulin plus gemcitabine versus paclitaxel plus gemcitabine (KCSG-BR-13-11).",2021,10.1016/j.esmoop.2021.100236,https://pubmed.ncbi.nlm.nih.gov/34438242/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,38092774,Analyzing aberrant DNA methylation in colorectal cancer uncovered intangible heterogeneity of gene effects in the survival time of patients.,2023,10.1038/s41598-023-47377-1,https://pubmed.ncbi.nlm.nih.gov/38092774/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,33328215,CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies.,2021,10.1158/2159-8290.cd-20-1243,https://pubmed.ncbi.nlm.nih.gov/33328215/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,33772408,MiR-375 potentially enhances GnRH expression by targeting Sp1 in GT1-7 cells.,2021,10.1007/s11626-020-00447-4,https://pubmed.ncbi.nlm.nih.gov/33772408/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,38028584,"Genetic diversity, population structure, and selective signature of sheep in the northeastern Tarim Basin.",2023,10.3389/fgene.2023.1281601,https://pubmed.ncbi.nlm.nih.gov/38028584/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,39308831,Population structure and selective signature of Kirghiz sheep by Illumina Ovine SNP50 BeadChip.,2024,10.7717/peerj.17980,https://pubmed.ncbi.nlm.nih.gov/39308831/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,29869113,TLE4 acts as a corepressor of Hes1 to inhibit inflammatory responses in macrophages.,2019,10.1007/s13238-018-0554-3,https://pubmed.ncbi.nlm.nih.gov/29869113/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,34886788,A Proteomics Study of the Subacute Toxicity of Rat Brain after Long- Term Exposure of Gelsemium elegans.,2022,10.2174/1874467214666211209144139,https://pubmed.ncbi.nlm.nih.gov/34886788/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLE4,ENSG00000106829,Unsafe,37370521,"Evaluation of the Genetic Diversity, Population Structure and Selection Signatures of Three Native Chinese Pig Populations.",2023,10.3390/ani13122010,https://pubmed.ncbi.nlm.nih.gov/37370521/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,40287404,TLK1 as a therapeutic target in TMZ resistant glioblastoma using small molecule inhibitor.,2025,10.1038/s41598-025-86599-3,https://pubmed.ncbi.nlm.nih.gov/40287404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,42149324,Platycodin D Overcomes Cisplatin Resistance in Gastric Cancer by Inducing Ferroptosis through TLK1-Dependent UHRF2/DNMT3A/ALOX15 Pathway.,2026,10.1007/s11655-026-3848-y,https://pubmed.ncbi.nlm.nih.gov/42149324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,39727191,Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interaction.,2025,10.1093/nar/gkae1279,https://pubmed.ncbi.nlm.nih.gov/39727191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,40369698,Mechanistic insights into Circ-MBOAT2-mediated regulation of TLK1 through miR-664b-3p in non-small cell lung cancer.,2025,10.1186/s41065-025-00439-y,https://pubmed.ncbi.nlm.nih.gov/40369698/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,40227796,Targeting the TLK1-MK5 Axis Suppresses Prostate Cancer Metastasis.,2025,10.3390/cancers17071187,https://pubmed.ncbi.nlm.nih.gov/40227796/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,38868186,De novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency.,2024,10.1016/j.isci.2024.109984,https://pubmed.ncbi.nlm.nih.gov/38868186/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,36947060,The interaction between ASF1B and TLK1 promotes the malignant progression of low-grade glioma.,2023,10.1080/07853890.2023.2169751,https://pubmed.ncbi.nlm.nih.gov/36947060/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,39994492,Plasma Exosomal circRNAs as Potential Biomarkers for Patients with Septic Shock-Induced Acute Kidney Injury.,2025,10.1002/bab.2736,https://pubmed.ncbi.nlm.nih.gov/39994492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,38111505,Tousled-like kinase 1 promotes gastric cancer progression by regulating the tumor growth factor-beta signaling pathway.,2023,10.3748/wjg.v29.i44.5919,https://pubmed.ncbi.nlm.nih.gov/38111505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,38925844,TLK1 Inhibition Enhances the Anticancer Effect of Deep UV Irradiation Through CHK1 Activation.,2024,10.21873/anticanres.17095,https://pubmed.ncbi.nlm.nih.gov/38925844/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,39029318,A novel approach to investigate the combinatorial effects of TLK1 (Tousled-Like Kinase1) inhibitors with Temozolomide for glioblastoma therapy.,2024,10.1016/j.bioorg.2024.107643,https://pubmed.ncbi.nlm.nih.gov/39029318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,37446279,"Targeting Prostate Cancer, the 'Tousled Way'.",2023,10.3390/ijms241311100,https://pubmed.ncbi.nlm.nih.gov/37446279/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,39199688,TLK1>Nek1 Axis Promotes Nuclear Retention and Activation of YAP with Implications for Castration-Resistant Prostate Cancer.,2024,10.3390/cancers16162918,https://pubmed.ncbi.nlm.nih.gov/39199688/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,36497211,"The TLK1-MK5 Axis Regulates Motility, Invasion, and Metastasis of Prostate Cancer Cells.",2022,10.3390/cancers14235728,https://pubmed.ncbi.nlm.nih.gov/36497211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,37439356,TLK1-mediated RAD54 phosphorylation spatio-temporally regulates Homologous Recombination Repair.,2023,10.1093/nar/gkad589,https://pubmed.ncbi.nlm.nih.gov/37439356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,35359342,Circular RNA TLK1 Exerts Oncogenic Functions in Hepatocellular Carcinoma by Acting as a ceRNA of miR-138-5p.,2022,10.1155/2022/2415836,https://pubmed.ncbi.nlm.nih.gov/35359342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,39796704,Beyond the Horizon: Rethinking Prostate Cancer Treatment Through Innovation and Alternative Strategies.,2024,10.3390/cancers17010075,https://pubmed.ncbi.nlm.nih.gov/39796704/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,37186176,Circular RNA as biomarkers for acute ischemic stroke: A systematic review and meta-analysis.,2023,10.1111/cns.14220,https://pubmed.ncbi.nlm.nih.gov/37186176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,35582542,Tousled-like kinase 1: a novel factor with multifaceted role in mCRPC progression and development of therapy resistance.,2022,10.20517/cdr.2021.109,https://pubmed.ncbi.nlm.nih.gov/35582542/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,35064619,TLK1-mediated MK5-S354 phosphorylation drives prostate cancer cell motility and may signify distinct pathologies.,2022,10.1002/1878-0261.13183,https://pubmed.ncbi.nlm.nih.gov/35064619/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,38001987,Exploiting TLK1 and Cisplatin Synergy for Synthetic Lethality in Androgen-Insensitive Prostate Cancer.,2023,10.3390/biomedicines11112987,https://pubmed.ncbi.nlm.nih.gov/38001987/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,37686173,Untousling the Role of Tousled-like Kinase 1 in DNA Damage Repair.,2023,10.3390/ijms241713369,https://pubmed.ncbi.nlm.nih.gov/37686173/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,39844055,Tousled-like kinase loss confers PARP inhibitor resistance in BRCA1-mutated cancers by impeding non-homologous end joining repair.,2025,10.1186/s10020-025-01066-z,https://pubmed.ncbi.nlm.nih.gov/39844055/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,35048066,Disorder at the Start: The Contribution of Dysregulated Translation Initiation to Cancer Therapy Resistance.,2021,10.3389/froh.2021.765931,https://pubmed.ncbi.nlm.nih.gov/35048066/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,32468002,Knockdown of Tousled‑like kinase 1 inhibits survival of glioblastoma multiforme cells.,2020,10.3892/ijmm.2020.4619,https://pubmed.ncbi.nlm.nih.gov/32468002/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,32905878,Generation of Phenothiazine with Potent Anti-TLK1 Activity for Prostate Cancer Therapy.,2020,10.1016/j.isci.2020.101474,https://pubmed.ncbi.nlm.nih.gov/32905878/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,31175227,The TOR Pathway Plays Pleiotropic Roles in Growth and Stress Responses of the Fungal Pathogen Cryptococcus neoformans.,2019,10.1534/genetics.119.302191,https://pubmed.ncbi.nlm.nih.gov/31175227/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,30737777,Targeting the TLK1/NEK1 DDR axis with Thioridazine suppresses outgrowth of androgen independent prostate tumors.,2019,10.1002/ijc.32200,https://pubmed.ncbi.nlm.nih.gov/30737777/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,28708136,Differential requirements for Tousled-like kinases 1 and 2 in mammalian development.,2017,10.1038/cdd.2017.108,https://pubmed.ncbi.nlm.nih.gov/28708136/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,31311824,Circular RNA TLK1 Aggravates Neuronal Injury and Neurological Deficits after Ischemic Stroke via miR-335-3p/TIPARP.,2019,10.1523/jneurosci.0299-19.2019,https://pubmed.ncbi.nlm.nih.gov/31311824/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,32755577,Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres.,2020,10.1016/j.celrep.2020.107983,https://pubmed.ncbi.nlm.nih.gov/32755577/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,26855419,"Tousled kinase activator, gallic acid, promotes homologous recombinational repair and suppresses radiation cytotoxicity in salivary gland cells.",2016,10.1016/j.freeradbiomed.2015.12.029,https://pubmed.ncbi.nlm.nih.gov/26855419/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,10588641,Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly.,1999,10.1091/mbc.10.12.4033,https://pubmed.ncbi.nlm.nih.gov/10588641/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TLK1,ENSG00000198586,Unsafe,9427565,"cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal.",1997,10.1016/s0378-1119(97)00495-2,https://pubmed.ncbi.nlm.nih.gov/9427565/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMED7,ENSG00000134970,Unsafe,41877912,Proteomic Analysis of Cerebrospinal Fluid: Toward the Identification of Biomarkers for Early Central Nervous System Infection.,2026,10.2147/idr.s570645,https://pubmed.ncbi.nlm.nih.gov/41877912/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMED7,ENSG00000134970,Unsafe,42205681,Evolocumab Alters Transcriptomic Signatures and Identifies Inflammatory Biomarkers in Brain-Heart Syndrome with Coronary Heart Disease History.,2026,10.2147/ijgm.s603395,https://pubmed.ncbi.nlm.nih.gov/42205681/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMED7,ENSG00000134970,Unsafe,40874303,Transcriptomic and Proteomic Insights Into Buffalo Milk Fat Synthesis and the Role of IGFBP4 in BMECs.,2025,10.1096/fj.202502191r,https://pubmed.ncbi.nlm.nih.gov/40874303/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMED7,ENSG00000134970,Unsafe,38453906,RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling.,2024,10.1038/s41467-024-45615-2,https://pubmed.ncbi.nlm.nih.gov/38453906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMED7,ENSG00000134970,Unsafe,37491993,Anterograde trafficking of Toll-like receptors requires the cargo sorting adaptors TMED-2 and 7.,2023,10.1111/tra.12912,https://pubmed.ncbi.nlm.nih.gov/37491993/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMED7,ENSG00000134970,Unsafe,33911883,Overexpression of microRNA-340-5p Ameliorates Inflammatory Response and Intracellular Survival of Mycobacterium Tuberculosis in Alveolar Type II Cells.,2021,10.2147/idr.s291867,https://pubmed.ncbi.nlm.nih.gov/33911883/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMED7,ENSG00000134970,Unsafe,35754792,TMED2/9/10 Serve as Biomarkers for Poor Prognosis in Head and Neck Squamous Carcinoma.,2022,10.3389/fgene.2022.895281,https://pubmed.ncbi.nlm.nih.gov/35754792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMED7,ENSG00000134970,Unsafe,33148610,AGS3-dependent trans-Golgi network membrane trafficking is essential for compaction in mouse embryos.,2020,10.1242/jcs.243238,https://pubmed.ncbi.nlm.nih.gov/33148610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMED7,ENSG00000134970,Unsafe,25808494,"Expression, sorting, and segregation of Golgi proteins during germ cell differentiation in the testis.",2015,10.1091/mbc.e14-12-1632,https://pubmed.ncbi.nlm.nih.gov/25808494/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMED7,ENSG00000134970,Unsafe,31102346,Dark side of the epididymis: tails of sperm maturation.,2019,10.1111/andr.12641,https://pubmed.ncbi.nlm.nih.gov/31102346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMED7,ENSG00000134970,Unsafe,32435407,Predictive Gene Signature for Pyrazolopyrimidine Derivative c-Src Inhibitor 10a Sensitivity in Melanoma Cells.,2020,10.1021/acsmedchemlett.9b00679,https://pubmed.ncbi.nlm.nih.gov/32435407/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMED7,ENSG00000134970,Unsafe,26311421,"Compartmentalization of membrane trafficking, glucose transport, glycolysis, actin, tubulin and the proteasome in the cytoplasmic droplet/Hermes body of epididymal sperm.",2015,10.1098/rsob.150080,https://pubmed.ncbi.nlm.nih.gov/26311421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMED7,ENSG00000134970,Unsafe,31258758,Clustered microRNAs hsa-miR-221-3p/hsa-miR-222-3p and their targeted genes might be prognostic predictors for hepatocellular carcinoma.,2019,10.7150/jca.29207,https://pubmed.ncbi.nlm.nih.gov/31258758/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMED7,ENSG00000134970,Unsafe,25074978,The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane.,2014,10.1126/scisignal.2005275,https://pubmed.ncbi.nlm.nih.gov/25074978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMED7,ENSG00000134970,Unsafe,24357726,Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma.,2014,10.1182/blood-2013-07-512392,https://pubmed.ncbi.nlm.nih.gov/24357726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMED7,ENSG00000134970,Unsafe,20178780,The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta.,2010,10.1016/j.ydbio.2010.02.019,https://pubmed.ncbi.nlm.nih.gov/20178780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMED7,ENSG00000134970,Unsafe,26881866,Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.,2016,10.1021/acs.chemrestox.5b00491,https://pubmed.ncbi.nlm.nih.gov/26881866/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMED7,ENSG00000134970,Unsafe,16308470,Identification of differentially expressed genes in metastatic and non-metastatic nasopharyngeal carcinoma cells by suppression subtractive hybridization.,2005,10.1155/2005/108490,https://pubmed.ncbi.nlm.nih.gov/16308470/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM140,ENSG00000146859,Unsafe,42100482,Integrated transcriptomic profiling combined with &lt;i&gt;in vitro&lt;/i&gt; validation reveals the involvement of TMEM140 in the link between periodontitis and brain aging.,2026,10.3389/fnagi.2026.1761218,https://pubmed.ncbi.nlm.nih.gov/42100482/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM140,ENSG00000146859,Unsafe,41944309,Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP-Mediated Invasion Activates Ras Signaling and Destabilizes p53.,2026,10.1002/advs.202517245,https://pubmed.ncbi.nlm.nih.gov/41944309/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM140,ENSG00000146859,Unsafe,39709506,Genetic analysis of psychosis Biotypes: shared Ancestry-adjusted polygenic risk and unique genomic associations.,2025,10.1038/s41380-024-02876-z,https://pubmed.ncbi.nlm.nih.gov/39709506/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM140,ENSG00000146859,Unsafe,40766309,The novel diagnostic markers for systemic lupus erythematosus and periodontal disease.,2025,10.3389/fimmu.2025.1614044,https://pubmed.ncbi.nlm.nih.gov/40766309/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM140,ENSG00000146859,Unsafe,26198430,TMEM140 is associated with the prognosis of glioma by promoting cell viability and invasion.,2015,10.1186/s13045-015-0187-4,https://pubmed.ncbi.nlm.nih.gov/26198430/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM140,ENSG00000146859,Unsafe,33498390,Differential DNA Methylation Landscape in Skin Fibroblasts from African Americans with Systemic Sclerosis.,2021,10.3390/genes12020129,https://pubmed.ncbi.nlm.nih.gov/33498390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM140,ENSG00000146859,Unsafe,33173609,Laser Capture Microdissection-Based RNA Microsequencing Reveals Optic Nerve Crush-Related Early mRNA Alterations in Retinal Ganglion Cell Layer.,2020,10.1167/tvst.9.11.30,https://pubmed.ncbi.nlm.nih.gov/33173609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM140,ENSG00000146859,Unsafe,27171439,Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.,2016,10.1371/journal.pone.0155660,https://pubmed.ncbi.nlm.nih.gov/27171439/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM140,ENSG00000146859,Unsafe,26329470,Erratum: TMEM140 is associated with the prognosis of glioma by promoting cell viability and invasion.,2015,10.1186/s13045-015-0199-0,https://pubmed.ncbi.nlm.nih.gov/26329470/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM140,ENSG00000146859,Unsafe,29616088,Retrospective screening of microarray data to identify candidate IFN-inducible genes in a HTLV-1 transformed model.,2018,10.3892/ol.2018.8014,https://pubmed.ncbi.nlm.nih.gov/29616088/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM140,ENSG00000146859,Unsafe,18317883,Identification of genes potentially involved in supporting hematopoietic stem cell activity of stromal cell line MC3T3-G2/PA6.,2008,10.1007/s12185-008-0048-9,https://pubmed.ncbi.nlm.nih.gov/18317883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM217,ENSG00000172738,Unsafe,41091759,Formation of a complex between TMEM217 and the sodium-proton exchanger SLC9C1 is crucial for mouse sperm motility and male fertility.,2025,10.1073/pnas.2513924122,https://pubmed.ncbi.nlm.nih.gov/41091759/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM217,ENSG00000172738,Unsafe,38510480,Identification of TMEM217 as a novel prognostic biomarker and potential therapeutic target in acute myeloid leukemia.,2024,10.1016/j.gendis.2023.06.010,https://pubmed.ncbi.nlm.nih.gov/38510480/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM217,ENSG00000172738,Unsafe,28431867,Whole exome sequencing identification of novel candidate genes in patients with proliferative diabetic retinopathy.,2017,10.1016/j.visres.2017.03.007,https://pubmed.ncbi.nlm.nih.gov/28431867/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM217,ENSG00000172738,Unsafe,26428916,Gene expression profiling of DMU-212-induced apoptosis and anti-angiogenesis in vascular endothelial cells.,2016,10.3109/13880209.2015.1071414,https://pubmed.ncbi.nlm.nih.gov/26428916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM225B,ENSG00000244219,Unsafe,30886340,De novo single-nucleotide and copy number variation in discordant monozygotic twins reveals disease-related genes.,2019,10.1038/s41431-019-0376-7,https://pubmed.ncbi.nlm.nih.gov/30886340/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM232,ENSG00000186952,Unsafe,39516485,TMEM232 is required for the formation of sperm flagellum and male fertility in mice.,2024,10.1038/s41419-024-07200-9,https://pubmed.ncbi.nlm.nih.gov/39516485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM232,ENSG00000186952,Unsafe,37371084,Deficiency of the Tmem232 Gene Causes Male Infertility with Morphological Abnormalities of the Sperm Flagellum in Mice.,2023,10.3390/cells12121614,https://pubmed.ncbi.nlm.nih.gov/37371084/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM232,ENSG00000186952,Unsafe,39596646,Effects of TMEM232 Variant on Infant Atopic Dermatitis According to Maternal Factors.,2024,10.3390/genes15111446,https://pubmed.ncbi.nlm.nih.gov/39596646/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM232,ENSG00000186952,Unsafe,36928730,TMEM232 promotes the inflammatory response in atopic dermatitis via the nuclear factor-κB and signal transducer and activator of transcription 3 signalling pathways.,2023,10.1093/bjd/ljad078,https://pubmed.ncbi.nlm.nih.gov/36928730/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM232,ENSG00000186952,Unsafe,37606455,Excessive Gestational Weight Gain Alters DNA Methylation and Influences Foetal and Neonatal Body Composition.,2023,10.3390/epigenomes7030018,https://pubmed.ncbi.nlm.nih.gov/37606455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM232,ENSG00000186952,Unsafe,42253507,Novel African American Colorectal Cancer &lt;i&gt;MSH3&lt;/i&gt; Variants Associate With Major Genomic Instability.,2026,10.1155/humu/5588764,https://pubmed.ncbi.nlm.nih.gov/42253507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM232,ENSG00000186952,Unsafe,34750414,Confirming the TMEM232 gene associated with atopic dermatitis through targeted capture sequencing.,2021,10.1038/s41598-021-01194-6,https://pubmed.ncbi.nlm.nih.gov/34750414/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM232,ENSG00000186952,Unsafe,38649688,Biallelic variants identified in 36 Pakistani families and trios with autism spectrum disorder.,2024,10.1038/s41598-024-57942-x,https://pubmed.ncbi.nlm.nih.gov/38649688/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM232,ENSG00000186952,Unsafe,34318869,Functionathon: a manual data mining workflow to generate functional hypotheses for uncharacterized human proteins and its application by undergraduate students.,2021,10.1093/database/baab046,https://pubmed.ncbi.nlm.nih.gov/34318869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM232,ENSG00000186952,Unsafe,36654975,Preliminary Study of Genome-Wide Association Identified Novel Susceptibility Genes for Hemorheological Indexes in a Chinese Population.,2022,10.1159/000524849,https://pubmed.ncbi.nlm.nih.gov/36654975/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM232,ENSG00000186952,Unsafe,28351738,Scanning indels in the 5q22.1 region and identification of the TMEM232 susceptibility gene that is associated with atopic dermatitis in the Chinese Han population.,2017,10.1016/j.gene.2017.03.034,https://pubmed.ncbi.nlm.nih.gov/28351738/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM232,ENSG00000186952,Unsafe,31712638,"KMT2C, a histone methyltransferase, is mutated in a family segregating non-syndromic primary failure of tooth eruption.",2019,10.1038/s41598-019-52935-7,https://pubmed.ncbi.nlm.nih.gov/31712638/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM232,ENSG00000186952,Unsafe,31064978,DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis.,2019,10.1038/s41467-019-09984-3,https://pubmed.ncbi.nlm.nih.gov/31064978/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM232,ENSG00000186952,Unsafe,29949836,"Association of Genetic Polymorphisms with Atopic Dermatitis, Clinical Severity and Total IgE: A Replication and Extended Study.",2018,10.4168/aair.2018.10.4.397,https://pubmed.ncbi.nlm.nih.gov/29949836/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM232,ENSG00000186952,Unsafe,31640099,"Genome-Wide Methylation of Mild Cognitive Impairment in Mexican Americans Highlights Genes Involved in Synaptic Transport, Alzheimer's Disease-Precursor Phenotypes, and Metabolic Morbidities.",2019,10.3233/jad-190634,https://pubmed.ncbi.nlm.nih.gov/31640099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM241,ENSG00000134490,Unsafe,37890669,TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport.,2023,10.1016/j.jlr.2023.100465,https://pubmed.ncbi.nlm.nih.gov/37890669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM241,ENSG00000134490,Unsafe,42511033,Genomic Analysis of the Columbian Plumage Pattern in Various Chicken Breeds.,2026,10.3390/ani16142153,https://pubmed.ncbi.nlm.nih.gov/42511033/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM241,ENSG00000134490,Unsafe,37792698,Genetics of vegetarianism: A genome-wide association study.,2023,10.1371/journal.pone.0291305,https://pubmed.ncbi.nlm.nih.gov/37792698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM241,ENSG00000134490,Unsafe,39736302,Whole genome and transcriptome analyses in dairy goats identify genetic markers associated with high milk yield.,2025,10.1016/j.ijbiomac.2024.139192,https://pubmed.ncbi.nlm.nih.gov/39736302/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM241,ENSG00000134490,Unsafe,36720443,Deciphering the chromatin spatial organization landscapes during BMMSC differentiation.,2023,10.1016/j.jgg.2023.01.009,https://pubmed.ncbi.nlm.nih.gov/36720443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM241,ENSG00000134490,Unsafe,39944650,Variations in rumen microbiota and host genome impacted feed efficiency in goat breeds.,2025,10.3389/fmicb.2025.1492742,https://pubmed.ncbi.nlm.nih.gov/39944650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM241,ENSG00000134490,Unsafe,27199446,Molecular Characterization of the Lipid Genome-Wide Association Study Signal on Chromosome 18q11.2 Implicates HNF4A-Mediated Regulation of the TMEM241 Gene.,2016,10.1161/atvbaha.116.307182,https://pubmed.ncbi.nlm.nih.gov/27199446/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM241,ENSG00000134490,Unsafe,25476127,Integrated differential transcriptome maps of Acute Megakaryoblastic Leukemia (AMKL) in children with or without Down Syndrome (DS).,2014,10.1186/s12920-014-0063-z,https://pubmed.ncbi.nlm.nih.gov/25476127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM241,ENSG00000134490,Unsafe,23027870,Hyperactivity of the Ero1α oxidase elicits endoplasmic reticulum stress but no broad antioxidant response.,2012,10.1074/jbc.m112.405050,https://pubmed.ncbi.nlm.nih.gov/23027870/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM31,ENSG00000179363,Unsafe,28454390,Expression of novel cancer/testis antigen TMEM31 increases during metastatic melanoma progression.,2017,10.3892/ol.2017.5728,https://pubmed.ncbi.nlm.nih.gov/28454390/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM31,ENSG00000179363,Unsafe,31079006,In silico analysis of transmembrane protein 31 (TMEM31) antigen to design novel multiepitope peptide and DNA cancer vaccines against melanoma.,2019,10.1016/j.molimm.2019.04.030,https://pubmed.ncbi.nlm.nih.gov/31079006/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM31,ENSG00000179363,Unsafe,34868337,Identification of the Upregulation of MRPL13 as a Novel Prognostic Marker Associated with Overall Survival Time and Immunotherapy Response in Breast Cancer.,2021,10.1155/2021/1498924,https://pubmed.ncbi.nlm.nih.gov/34868337/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM95,ENSG00000182896,Unsafe,41233479,Spermatozoa lacking TEX51 display hypofertility and defects in morphology.,2025,10.1038/s42003-025-08937-5,https://pubmed.ncbi.nlm.nih.gov/41233479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM95,ENSG00000182896,Unsafe,40711049,"Impact of Polystyrene Microplastics on Human Sperm Functionality: An In Vitro Study of Cytotoxicity, Genotoxicity and Fertility-Related Genes Expression.",2025,10.3390/toxics13070605,https://pubmed.ncbi.nlm.nih.gov/40711049/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM95,ENSG00000182896,Unsafe,35409288,The Role of Sperm Proteins IZUMO1 and TMEM95 in Mammalian Fertilization: A Systematic Review.,2022,10.3390/ijms23073929,https://pubmed.ncbi.nlm.nih.gov/35409288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM95,ENSG00000182896,Unsafe,40239489,Transmembrane protein 95 as a promising molecular marker of ram sperm functionality.,2025,10.1016/j.theriogenology.2025.117440,https://pubmed.ncbi.nlm.nih.gov/40239489/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM95,ENSG00000182896,Unsafe,40058809,Molecular mechanisms leading to gamete fusion.,2025,10.5387/fms.24-00046,https://pubmed.ncbi.nlm.nih.gov/40058809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM95,ENSG00000182896,Unsafe,32393636,"Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice.",2020,10.1073/pnas.1922650117,https://pubmed.ncbi.nlm.nih.gov/32393636/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM95,ENSG00000182896,Unsafe,35721474,The Sperm Olfactory Receptor OLFR601 is Dispensable for Mouse Fertilization.,2022,10.3389/fcell.2022.854115,https://pubmed.ncbi.nlm.nih.gov/35721474/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM95,ENSG00000182896,Unsafe,36161911,Human sperm TMEM95 binds eggs and facilitates membrane fusion.,2022,10.1073/pnas.2207805119,https://pubmed.ncbi.nlm.nih.gov/36161911/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM95,ENSG00000182896,Unsafe,32484434,TMEM95 is a sperm membrane protein essential for mammalian fertilization.,2020,10.7554/elife.53913,https://pubmed.ncbi.nlm.nih.gov/32484434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM95,ENSG00000182896,Unsafe,26385321,Identification of novel alternative splicing transcript and expression analysis of bovine TMEM95 gene.,2016,10.1016/j.gene.2015.09.026,https://pubmed.ncbi.nlm.nih.gov/26385321/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM95,ENSG00000182896,Unsafe,37453426,The EGF-motif-containing protein SPE-36 is a secreted sperm protein required for fertilization in C. elegans.,2023,10.1016/j.cub.2023.06.051,https://pubmed.ncbi.nlm.nih.gov/37453426/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM95,ENSG00000182896,Unsafe,35096839,Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats.,2021,10.3389/fcell.2021.810118,https://pubmed.ncbi.nlm.nih.gov/35096839/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM95,ENSG00000182896,Unsafe,31315171,Detection of Bovine TMEM95 p.Cys161X Mutation in 13 Chinese Indigenous Cattle Breeds.,2019,10.3390/ani9070444,https://pubmed.ncbi.nlm.nih.gov/31315171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM95,ENSG00000182896,Unsafe,37752425,Genome-wide landscape of runs of homozygosity and differentiation across Egyptian goat breeds.,2023,10.1186/s12864-023-09679-6,https://pubmed.ncbi.nlm.nih.gov/37752425/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM95,ENSG00000182896,Unsafe,28859280,Subfertility in bulls carrying a nonsense mutation in transmembrane protein 95 is due to failure to interact with the oocyte vestments.,2017,10.1093/biolre/iox065,https://pubmed.ncbi.nlm.nih.gov/28859280/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM95,ENSG00000182896,Unsafe,25064398,Integrative DNA methylation and gene expression analysis identifies discoidin domain receptor 1 association with idiopathic nonobstructive azoospermia.,2014,10.1016/j.fertnstert.2014.06.028,https://pubmed.ncbi.nlm.nih.gov/25064398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMEM95,ENSG00000182896,Unsafe,24391514,A nonsense mutation in TMEM95 encoding a nondescript transmembrane protein causes idiopathic male subfertility in cattle.,2014,10.1371/journal.pgen.1004044,https://pubmed.ncbi.nlm.nih.gov/24391514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPPE,ENSG00000188167,Unsafe,29317602,Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank.,2018,10.1038/s41398-017-0034-1,https://pubmed.ncbi.nlm.nih.gov/29317602/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS11F,ENSG00000198092,Unsafe,40556423,TMEM106B Supports Viral Entry and Syncytia Formation Mediated by the Spike Proteins From Omicron BA.2.86 and JN.1.,2025,10.1002/jmv.70439,https://pubmed.ncbi.nlm.nih.gov/40556423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS11F,ENSG00000198092,Unsafe,35403268,Construction of a prognostic risk assessment model for lung adenocarcinoma based on Integrin β family-related genes.,2022,10.1002/jcla.24419,https://pubmed.ncbi.nlm.nih.gov/35403268/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS11F,ENSG00000198092,Unsafe,28338078,The Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss.,2017,10.1038/srep45262,https://pubmed.ncbi.nlm.nih.gov/28338078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS11F,ENSG00000198092,Unsafe,32625238,New Analysis Framework Incorporating Mixed Mutual Information and Scalable Bayesian Networks for Multimodal High Dimensional Genomic and Epigenomic Cancer Data.,2020,10.3389/fgene.2020.00648,https://pubmed.ncbi.nlm.nih.gov/32625238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS9,ENSG00000178297,Unsafe,40652049,Combination of genetic studies and animal modeling proposes TMPRSS9 as a candidate gene for serum K+ variations.,2025,10.1038/s41598-025-11106-7,https://pubmed.ncbi.nlm.nih.gov/40652049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS9,ENSG00000178297,Unsafe,34758722,Azoospermia and reciprocal translocations: should whole-exome sequencing be recommended?,2021,10.1186/s12610-021-00145-5,https://pubmed.ncbi.nlm.nih.gov/34758722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS9,ENSG00000178297,Unsafe,31943016,Combination of whole exome sequencing and animal modeling identifies TMPRSS9 as a candidate gene for autism spectrum disorder.,2020,10.1093/hmg/ddz305,https://pubmed.ncbi.nlm.nih.gov/31943016/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS9,ENSG00000178297,Unsafe,37042750,Identification of Embryonic Chicken Proteases Activating Newcastle Disease Virus and Their Roles in the Pathogenicity of Virus Used as In Ovo Vaccine.,2023,10.1128/jvi.00324-23,https://pubmed.ncbi.nlm.nih.gov/37042750/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS9,ENSG00000178297,Unsafe,39151574,Integrative analysis of transcriptome-wide association study and mRNA expression profile identified risk genes for bipolar disorder.,2024,10.1016/j.neulet.2024.137935,https://pubmed.ncbi.nlm.nih.gov/39151574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS9,ENSG00000178297,Unsafe,33537060,"The Dynamic Expression of Potential Mediators of Severe Acute Respiratory Syndrome Coronavirus 2 Cellular Entry in Fetal, Neonatal, and Adult Rhesus Monkeys.",2020,10.3389/fgene.2020.607479,https://pubmed.ncbi.nlm.nih.gov/33537060/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS9,ENSG00000178297,Unsafe,33932994,RNA sequencing-based analysis of the magnum tissues revealed the novel genes and biological pathways involved in the egg-white formation in the laying hen.,2021,10.1186/s12864-021-07634-x,https://pubmed.ncbi.nlm.nih.gov/33932994/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS9,ENSG00000178297,Unsafe,24756697,Polyserase-1/TMPRSS9 induces pro-tumor effects in pancreatic cancer cells by activation of pro-uPA.,2014,10.3892/or.2014.3146,https://pubmed.ncbi.nlm.nih.gov/24756697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS9,ENSG00000178297,Unsafe,30449631,Genome-wide interaction study of gene-by-occupational exposures on respiratory symptoms.,2019,10.1016/j.envint.2018.11.017,https://pubmed.ncbi.nlm.nih.gov/30449631/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS9,ENSG00000178297,Unsafe,16872279,"Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates urokinase-type plasminogen activator and the proteolytic activation is negatively regulated by glycosaminoglycans.",2006,10.1042/bj20060212,https://pubmed.ncbi.nlm.nih.gov/16872279/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS9,ENSG00000178297,Unsafe,25582750,Identification of stage-specific markers during differentiation of hair cells from mouse inner ear stem cells or progenitor cells in vitro.,2015,10.1016/j.biocel.2014.12.024,https://pubmed.ncbi.nlm.nih.gov/25582750/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS9,ENSG00000178297,Unsafe,17655505,Identification and analysis of the promoter region of the type II transmembrane serine protease polyserase-1 and its transcript variants.,2007,10.1515/bc.2007.093,https://pubmed.ncbi.nlm.nih.gov/17655505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TMPRSS9,ENSG00000178297,Unsafe,12886014,"Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product.",2003,10.1073/pnas.1633392100,https://pubmed.ncbi.nlm.nih.gov/12886014/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42049430,NLRP3 and RANK-RANKL-OPG Pathway-related Gene Expression Levels in Children With Autism Spectrum Disorder.,2026,10.21873/invivo.14319,https://pubmed.ncbi.nlm.nih.gov/42049430/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42332539,"The role of neutrophils, fibroblasts, and osteoclasts in periodontitis: A transcriptomic and single-cell analysis.",2026,10.1097/md.0000000000049382,https://pubmed.ncbi.nlm.nih.gov/42332539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42635043,TRANCE is a unique marker of chronic pancreatitis in children.,2026,10.1172/jci.insight.198911,https://pubmed.ncbi.nlm.nih.gov/42635043/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,41461683,Genomic analysis unlocks the potential of denosumab as a targeted therapy for Crohn's disease.,2025,10.1038/s41598-025-28395-7,https://pubmed.ncbi.nlm.nih.gov/41461683/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42882213,"Gingival Crevicular Fluid Levels of Parathyroid Hormone-Related Protein, RANK Ligand, and Osteoprotegerin in Periodontal Health, Gingivitis, and Periodontitis: A Cross-Sectional Study.",2026,10.3390/jcm15197752,https://pubmed.ncbi.nlm.nih.gov/42882213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42805952,C-type lectin receptors: bone remodeling and therapeutic potential.,2026,10.1038/s41413-026-00567-9,https://pubmed.ncbi.nlm.nih.gov/42805952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42602299,Role of the Antioxidant Lycopene in Bone Health: Emphasis on the RANKL/RANK/OPG Signaling Pathway.,2026,10.1002/fsn3.72229,https://pubmed.ncbi.nlm.nih.gov/42602299/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42572248,"Targeting RANKL Prevents Bone Loss, Improves Muscle Function and Extends Lifespan in Progeroid Mice.",2026,10.1111/acel.70655,https://pubmed.ncbi.nlm.nih.gov/42572248/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42158288,Transcriptomic profiling and RANKL/RANK/OPG-mediated osteoclastogenesis in zebrafish larvae under simulated microgravity conditions.,2026,10.3389/fcell.2026.1786373,https://pubmed.ncbi.nlm.nih.gov/42158288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42322574,Gene polymorphism and serum level of RANKL among patients with rheumatoid arthritis: a systematic review and meta-analysis.,2026,10.14715/cmb/2025.72.3.4,https://pubmed.ncbi.nlm.nih.gov/42322574/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42738900,A Truncated Serpin D1 Variant Regulates Adseverin-Dependent Actin Severing and Is Required for Osteoclastogenesis.,2026,10.3390/cells15171607,https://pubmed.ncbi.nlm.nih.gov/42738900/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42564269,TNF-α blockade with adalimumab restores bone metabolism in rheumatoid arthritis by regulating cytokines and inflammatory cell infiltration.,2026,10.3389/fimmu.2026.1866519,https://pubmed.ncbi.nlm.nih.gov/42564269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42503518,Targeting IFN-I driven tertiary lymphoid structures halts B cell-mediated bone loss in periodontitis.,2026,10.1038/s41368-026-00450-7,https://pubmed.ncbi.nlm.nih.gov/42503518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42187765,Histological Evaluation of Radiotherapy-Induced Changes in Periodontal Tissues in a Rat Model of Experimental Periodontitis.,2026,10.3390/biology15100803,https://pubmed.ncbi.nlm.nih.gov/42187765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,41734157,Brain activity and the production of written text during mediumistic trance: A controlled EEG study.,2026,10.1371/journal.pone.0343216,https://pubmed.ncbi.nlm.nih.gov/41734157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,41825583,Porphyromonas gingivalis lipids enhance RANKL-mediated osteoclast formation.,2026,10.1016/j.bone.2026.117852,https://pubmed.ncbi.nlm.nih.gov/41825583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42272924,"Crosstalk with bone marrow adipocytes, but not osteoblasts, drives a cortical bone resorption phenotype in female mice with adult-onset deletion of the glucocorticoid receptor in Osterix-expressing cells.",2026,10.1093/jbmrpl/ziag090,https://pubmed.ncbi.nlm.nih.gov/42272924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42375605,RANKL-RANK signaling promotes cigarette smoke-induced emphysema with MMP-9 upregulation in alveolar macrophages.,2026,10.3389/fphar.2026.1754836,https://pubmed.ncbi.nlm.nih.gov/42375605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42781185,Osteoprotegerin and receptor activator of NF-kappaB ligand as biomarkers for bone resorption-related disorders.,2026,10.5493/wjem.120531,https://pubmed.ncbi.nlm.nih.gov/42781185/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42727731,Trauma-specific and time-dependent changes of the RANK/RANKL/OPG signaling axis in the periapical bone tissue after experimental traumatic dental injuries in rats.,2026,10.1016/j.bbagen.2026.131002,https://pubmed.ncbi.nlm.nih.gov/42727731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42823111,"Efficacy and safety of narlumosbart in combination with stereotactic body radiation therapy followed by first-line chemotherapy combined with immunotherapy in advanced driver gene-negative non-small cell lung cancer patients with bone metastases: a phase II, single-arm, single-centre clinical trial protocol.",2026,10.1136/bmjopen-2026-120892,https://pubmed.ncbi.nlm.nih.gov/42823111/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42712902,Thymic regeneration and tumor immunotherapy.,2026,10.3389/fimmu.2026.1891681,https://pubmed.ncbi.nlm.nih.gov/42712902/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42445399,Efficacy and safety of combined RANKL and PD-1 inhibitors in bone metastases: a retrospective study.,2026,10.21037/tcr-2026-1-0312,https://pubmed.ncbi.nlm.nih.gov/42445399/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42644021,Rewiring osteoimmune homeostasis in osteoporosis: T-cell subsets as key regulators and emerging therapeutic targets.,2026,10.3389/fimmu.2026.1926935,https://pubmed.ncbi.nlm.nih.gov/42644021/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42591919,"RANKL-convergent osteoimmune network framework in osteoporosis: integrating macrophage activation, T-cell imbalance, and cytokine crosstalk.",2026,10.3389/fimmu.2026.1911132,https://pubmed.ncbi.nlm.nih.gov/42591919/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42336709,Pembrolizumab and Denosumab in Clear-Cell Renal-Cell Carcinoma.,2026,10.1016/j.clgc.2026.102585,https://pubmed.ncbi.nlm.nih.gov/42336709/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42818898,Traditional Chinese medicine regulating Wnt/β-catenin and OPG/RANKL/RANK pathways in osteoporosis: a narrative review based on bone coupling and pathological subtype differences.,2026,10.3389/fmed.2026.1924175,https://pubmed.ncbi.nlm.nih.gov/42818898/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,40936894,Immunosuppressive tumor microenvironment and advance in immunotherapy in melanoma bone metastasis.,2025,10.3389/fimmu.2025.1608215,https://pubmed.ncbi.nlm.nih.gov/40936894/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42526401,Metabolic checkpoints in bone remodeling: from dysregulation to targeted therapies.,2026,10.1016/j.clinsp.2026.101060,https://pubmed.ncbi.nlm.nih.gov/42526401/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42662138,Advances in the association between tumor immune microenvironment remodeling in osteosarcoma and the risk of pathological fractures.,2026,10.3389/fgene.2026.1882506,https://pubmed.ncbi.nlm.nih.gov/42662138/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,40669444,RANKL/PD-1 dual blockade demonstrates survival benefit for patients with advanced lung adenocarcinoma harboring KRAS mutations.,2025,10.1016/j.xcrm.2025.102235,https://pubmed.ncbi.nlm.nih.gov/40669444/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42345808,"The Effects of Bisphosphonates Used in Osteoporosis Treatment on Breast Cancer: Analysis with Integrative Bioinformatics Methods, DFT, ADMET and Molecular Docking Analysis.",2026,10.3390/biology15120952,https://pubmed.ncbi.nlm.nih.gov/42345808/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42597939,Progress on novel compounds for the treatment of bone metabolism-related disorders: focus on osteoporosis and beyond.,2026,10.3389/fchem.2026.1861883,https://pubmed.ncbi.nlm.nih.gov/42597939/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42824795,"Immune checkpoint inhibition in bone metastases: lesion response heterogeneity, the osteoimmune niche, and microenvironment-directed therapy.",2026,10.3389/fimmu.2026.1959101,https://pubmed.ncbi.nlm.nih.gov/42824795/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42454030,Fueling bone loss: the immunometabolic reprogramming of the bone microenvironment in diabetic osteoporosis.,2026,10.3389/fimmu.2026.1850044,https://pubmed.ncbi.nlm.nih.gov/42454030/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42558368,Molecular mechanisms and translational prospects in osteoporosis.,2026,10.3389/fendo.2026.1907271,https://pubmed.ncbi.nlm.nih.gov/42558368/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF11,ENSG00000120659,Unsafe,42462530,Dihydrobaicalein suppresses osteoclast differentiation and mitochondrial transfer to prevent postmenopausal osteoporosis.,2026,10.1016/j.phymed.2026.158564,https://pubmed.ncbi.nlm.nih.gov/42462530/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,41892249,TNFSF4/OX40L and IKZF1/IKAROS Genetic Variant Associations with Egyptian Juvenile Systemic Lupus Erythematosus (JSLE).,2026,10.3390/biology15060489,https://pubmed.ncbi.nlm.nih.gov/41892249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,41471849,Downregulation of oar-miR-125b Drives Blood-Brain Barrier Breakdown Through the TNFSF4-NF-κB Inflammatory Axis in Enterococcus Faecalis Meningitis.,2025,10.3390/microorganisms13122644,https://pubmed.ncbi.nlm.nih.gov/41471849/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,40493100,Multi-omics analysis of tumor necrosis factor superfamily 4 reveals its prognostic value with T cell exhaustion feature in cancer.,2025,10.1007/s12672-025-02666-1,https://pubmed.ncbi.nlm.nih.gov/40493100/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,41689774,Identification of the Inflammatory Cytokine Tumor Necrosis Factor Superfamily 4 as an Oncogenic Driver and Potential Druggable Target in Hepatocellular Carcinoma.,2026,10.1111/hepr.70135,https://pubmed.ncbi.nlm.nih.gov/41689774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,40254578,Identifying TNFSF4&lt;sup&gt;low&lt;/sup&gt;-MSCs superiorly treating idiopathic pulmonary fibrosis through Tregs differentiation modulation.,2025,10.1186/s13287-025-04313-6,https://pubmed.ncbi.nlm.nih.gov/40254578/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,41026121,TNFSF4 Promotes Bone Erosion in Rheumatoid Arthritis by Enhancing the Inflammatory Response of Synovial Macrophages.,2025,10.1096/fj.202501883rr,https://pubmed.ncbi.nlm.nih.gov/41026121/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,42358961,Identification of oxidative stress-associated biomarkers for inflammatory bowel disease through integrated machine learning and weighted gene co-expression network analysis.,2026,10.3389/fimmu.2026.1763786,https://pubmed.ncbi.nlm.nih.gov/42358961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,41234826,"Constructing an immune-related prognostic model and exploring the function of HMGB3, TNFSF4, and CORO2A in breast cancer.",2025,10.21037/tcr-2025-1049,https://pubmed.ncbi.nlm.nih.gov/41234826/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,39825223,Pan-cancer analysis shows that TNFSF4 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including liver cancer.,2025,10.1186/s12885-025-13479-4,https://pubmed.ncbi.nlm.nih.gov/39825223/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,40624624,Integrated analysis of polytranscriptomics reveals TNFSF ligand genes in pancreatic cancer prognosis and immune regulation.,2025,10.1186/s12865-025-00733-4,https://pubmed.ncbi.nlm.nih.gov/40624624/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,41202012,Structural and evolutionary constraints shape adaptive landscapes of immune-related genes across mammalian phylogeny.,2025,10.1371/journal.pone.0332734,https://pubmed.ncbi.nlm.nih.gov/41202012/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,41678619,Transcription factor Etv3 controls the tolerogenic function of dendritic cells.,2026,10.1126/science.ads1246,https://pubmed.ncbi.nlm.nih.gov/41678619/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,42653386,Genomic Landscape of Systemic Lupus Erythematosus and Lupus Nephritis Globally and the Gaps in Africa.,2026,10.3390/ijms27167383,https://pubmed.ncbi.nlm.nih.gov/42653386/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,42156591,An epigenetic switch in vascular phenotype augments anti-tumor immunity.,2026,10.1007/s10456-026-10042-y,https://pubmed.ncbi.nlm.nih.gov/42156591/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,41102682,Analysis of FNDC1 as a diagnostic marker and potential therapeutic target for ovarian serous cancer.,2025,10.1186/s12885-025-14924-0,https://pubmed.ncbi.nlm.nih.gov/41102682/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,40972652,LIGHT in combination with IL-13 or IL-17 drives inflammatory transcriptional signatures in human pulmonary fibroblasts relevant for human lung disease.,2025,10.1093/immhor/vlaf042,https://pubmed.ncbi.nlm.nih.gov/40972652/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,41165588,Distinct expression profiles of inflammasome-associated genes in systemic juvenile idiopathic arthritis.,2026,10.1093/rheumatology/keaf576,https://pubmed.ncbi.nlm.nih.gov/41165588/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,39856662,MiR-125b-5p ameliorates ox-LDL-induced vascular endothelial cell dysfunction by negatively regulating TNFSF4/TLR4/NF-κB signaling.,2025,10.1186/s12896-025-00944-y,https://pubmed.ncbi.nlm.nih.gov/39856662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,40292102,Constructing a neural network model based on tumor-infiltrating lymphocytes (TILs) to predict the survival of hepatocellular carcinoma patients.,2025,10.7717/peerj.19351,https://pubmed.ncbi.nlm.nih.gov/40292102/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,40908857,Acute Hyperinsulinemia during Hyperinsulinemic- Euglycemic Clamp Influences DNA Methylation and Gene Expression in Peripheral Blood Cells of Adult Men.,2026,10.4093/dmj.2025.0072,https://pubmed.ncbi.nlm.nih.gov/40908857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,41561762,OX40/OX40L: a new target for tumor immunotherapy and its clinical research progress.,2025,10.3389/fonc.2025.1730620,https://pubmed.ncbi.nlm.nih.gov/41561762/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,38526805,OX40/OX40 ligand and its role in precision immune oncology.,2024,10.1007/s10555-024-10184-9,https://pubmed.ncbi.nlm.nih.gov/38526805/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,41310864,Molecular subtyping and a seven-gene immune signature reveal heterogeneity in tumor microenvironment and prognosis of lung adenocarcinoma.,2025,10.1186/s40001-025-03544-w,https://pubmed.ncbi.nlm.nih.gov/41310864/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,40965741,MiR-26b-5p mediates radioresistance and immunosuppression via targeting PRKCD in non-small cell lung cancer.,2025,10.1007/s00432-025-06310-x,https://pubmed.ncbi.nlm.nih.gov/40965741/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,40083872,Tumor gene expression signatures associated with outcome in large B-cell lymphoma treated with CD19-directed CAR T-cell therapy (axicabtagene ciloleucel).,2025,10.3389/fonc.2025.1519473,https://pubmed.ncbi.nlm.nih.gov/40083872/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,40061889,Prognostic significance of the inhibitory-to-stimulatory immune checkpoint ratio in patients with breast cancer.,2025,10.3389/fonc.2025.1524861,https://pubmed.ncbi.nlm.nih.gov/40061889/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNFSF4,ENSG00000117586,Unsafe,39945271,Bioinformatics Analysis of Key Genes Associated with Resistance to the Combination of Bevacizumab and Pemetrexed Chemotherapy in Non-small Cell Lung Cancer.,2025,10.2174/0115748928376905250210055408,https://pubmed.ncbi.nlm.nih.gov/39945271/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,42555892,TFEB Deficiency Impairs Male Fertility Through Mitochondrial Dysfunction.,2026,10.1096/fj.202601937rr,https://pubmed.ncbi.nlm.nih.gov/42555892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,42791710,Transcriptomic Dynamics and ECM Remodeling During Postnatal Testicular Maturation in the Tianzhu White Yak.,2026,10.3390/ani16182853,https://pubmed.ncbi.nlm.nih.gov/42791710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,42812170,"Impaired antigen clearance of macrophages associates with heart failure and non-obstructive azoospermia: insights from transcriptomics, in silico knockout, and &lt;i&gt;in vitro&lt;/i&gt; validation.",2026,10.3389/fimmu.2026.1909437,https://pubmed.ncbi.nlm.nih.gov/42812170/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,42278056,Single-Cell RNA Sequencing Reveals Dynamic Transcriptional Landscape of Testicular Maturation in Dezhou Donkeys.,2026,10.3390/ani16111621,https://pubmed.ncbi.nlm.nih.gov/42278056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,42468500,Deciphering testicular aging through whole transcriptome sequencing and ceRNA network analysis in cattle.,2026,10.1016/j.theriogenology.2026.118089,https://pubmed.ncbi.nlm.nih.gov/42468500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,41594366,A Comprehensive Atlas of Testicular lncRNAs Reveals Dynamic Changes and Regulatory Networks During Sexual Maturation in Tibetan Sheep.,2026,10.3390/ani16020176,https://pubmed.ncbi.nlm.nih.gov/41594366/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,41866036,PRAMEL12 orchestrates spermiogenesis to ensure male fertility in mice.,2026,10.1016/j.jbc.2026.111392,https://pubmed.ncbi.nlm.nih.gov/41866036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,42468183,"Dibromoacetic acid impairs spermatogenesis: integrative evidence from human epidemiology, network toxicology, and mechanistic validation.",2026,10.1016/j.envint.2026.110425,https://pubmed.ncbi.nlm.nih.gov/42468183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,42622507,"Spastic and non-spastic spinal cord injury induce systemic reproductive impairment via alterations in testicular morphology, microenvironment, spermatogenesis, and modulation of sperm parameters.",2026,10.1080/10790268.2026.2709255,https://pubmed.ncbi.nlm.nih.gov/42622507/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,40077949,Evaluation of &lt;i&gt;TNP1&lt;/i&gt; and &lt;i&gt;PRM1&lt;/i&gt; gene expression in male infertility patients with low or high sperm DNA fragmentation.,2025,10.4274/jtgga.galenos.2024.2024-5-3,https://pubmed.ncbi.nlm.nih.gov/40077949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,40858886,Combination of knockout serum replacement and plasma rich in growth factors does not support in vitro spermatogenesis in mice.,2025,10.1038/s41598-025-16502-7,https://pubmed.ncbi.nlm.nih.gov/40858886/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,41490753,Male reproductive impairment linked to occupational ionizing radiation exposure in radiology workers.,2026,10.1016/j.reprotox.2026.109160,https://pubmed.ncbi.nlm.nih.gov/41490753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,39404405,Establishment and Characterization of Testis Organoids with Proliferation and Differentiation of Spermatogonial Stem Cells into Spermatocytes and Spermatids.,2024,10.3390/cells13191642,https://pubmed.ncbi.nlm.nih.gov/39404405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,39688669,Coevolution and Adaptation of Transition Nuclear Proteins and Protamines in Naturally Ascrotal Mammals Support the Black Queen Hypothesis.,2024,10.1093/gbe/evae260,https://pubmed.ncbi.nlm.nih.gov/39688669/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,41136666,Environmental light deprivation disrupts Leydig cell maturation and male reproductive development in rats.,2025,10.1038/s41598-025-21236-7,https://pubmed.ncbi.nlm.nih.gov/41136666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,40676622,Circadian disruption impairs Leydig cell maturation and reproductive development in male rats.,2025,10.1186/s12958-025-01440-w,https://pubmed.ncbi.nlm.nih.gov/40676622/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,38596069,"Key chromatin regulator-related genes associated with the risk of coronary artery disease regulate the expression of HCFC1, RNF8, TNP1 and SET.",2024,10.1016/j.heliyon.2024.e28685,https://pubmed.ncbi.nlm.nih.gov/38596069/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,39028130,Adverse Effects of Nicotine on Human Sperm Nuclear Proteins.,2025,10.5534/wjmh.240072,https://pubmed.ncbi.nlm.nih.gov/39028130/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,39849580,In vitro sperm generation from immature mouse testicular tissue using plasma rich in growth factors.,2025,10.1186/s13287-025-04136-5,https://pubmed.ncbi.nlm.nih.gov/39849580/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,39776796,A general strategy towards activatable nanophotosensitizer for phototoxicity-free photodynamic therapy.,2025,10.7150/thno.100597,https://pubmed.ncbi.nlm.nih.gov/39776796/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,40311472,BDE-209 toxicity: From spermiogenesis to sexual maturity in F1 male mice.,2025,10.1016/j.ecoenv.2025.118231,https://pubmed.ncbi.nlm.nih.gov/40311472/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,39245200,Prenatal exposure to environmentally relevant levels of PAHs inhibits spermatogenesis in adult mice and the mechanism involved.,2024,10.1016/j.envpol.2024.124914,https://pubmed.ncbi.nlm.nih.gov/39245200/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,37643832,Transition nuclear protein 1 as a novel biomarker in patients with fertilization failure.,2023,10.5653/cerm.2023.05890,https://pubmed.ncbi.nlm.nih.gov/37643832/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,38798119,Sodium arsenite impairs sperm quality via downregulating the ZMYND15 and ZMYND10.,2024,10.1002/tox.24327,https://pubmed.ncbi.nlm.nih.gov/38798119/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,36803971,A novel DNA damage repair gene-related prognostic model for evaluating the prognosis and tumor microenvironment infiltration of esophageal squamous cell carcinoma.,2023,10.1186/s12920-023-01459-1,https://pubmed.ncbi.nlm.nih.gov/36803971/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,39572374,"Testicular histopathology and its association with germ cell numbers, serum concentrations of reproductive hormones, and semen quality.",2026,10.1111/andr.13803,https://pubmed.ncbi.nlm.nih.gov/39572374/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,38786072,Interaction between Chromodomain Y-like Protein and Androgen Receptor Signaling in Sertoli Cells Accounts for Spermatogenesis.,2024,10.3390/cells13100851,https://pubmed.ncbi.nlm.nih.gov/38786072/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,34494233,Cryoprotective Effect of Pentoxifylline on Spermatogonial Stem Cell During Transplantation into Azoospermic Torsion Mouse Model.,2022,10.1007/s43032-021-00729-6,https://pubmed.ncbi.nlm.nih.gov/34494233/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,35717571,Mini Bioreactor Can Support In Vitro Spermatogenesis of Mouse Testicular Tissue.,2022,10.22074/cellj.2022.8053,https://pubmed.ncbi.nlm.nih.gov/35717571/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,35052491,Changes in Expression of Specific mRNA Transcripts after Single- or Re-Irradiation in Mouse Testes.,2022,10.3390/genes13010151,https://pubmed.ncbi.nlm.nih.gov/35052491/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,30551142,Cytological and molecular aspects of the ageing sperm.,2019,10.1093/humrep/dey357,https://pubmed.ncbi.nlm.nih.gov/30551142/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,30087569,ISEcp1-mediated transposition of chromosome-borne blaCMY-2 into an endogenous ColE1-like plasmid in Escherichia coli.,2018,10.2147/idr.s159345,https://pubmed.ncbi.nlm.nih.gov/30087569/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,26088866,Expansion and long-term culture of human spermatogonial stem cells via the activation of SMAD3 and AKT pathways.,2015,10.1177/1535370215590822,https://pubmed.ncbi.nlm.nih.gov/26088866/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TNP1,ENSG00000118245,Unsafe,9809674,Expression of mRNA and protein of nucleoproteins during human spermiogenesis.,1998,10.1093/molehr/4.10.939,https://pubmed.ncbi.nlm.nih.gov/9809674/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOMM20L,ENSG00000196860,Unsafe,34290169,CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice.,2022,10.4103/aja.aja_63_21,https://pubmed.ncbi.nlm.nih.gov/34290169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOMM20L,ENSG00000196860,Unsafe,31889427,Seeking for potential pathogenic genes of major depressive disorder in the Gene Expression Omnibus database.,2020,10.1111/appy.12379,https://pubmed.ncbi.nlm.nih.gov/31889427/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42679034,A multispecies toolkit of &lt;i&gt;TOP2&lt;/i&gt; hypercleavage mutants for studying topoisomerase II-mediated DNA damage.,2026,10.1073/pnas.2616452123,https://pubmed.ncbi.nlm.nih.gov/42679034/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42442624,"Targeting DNA topoisomerase II in Cancer: mechanism of inhibition, clinical utility, and future directions.",2026,10.1016/j.gene.2026.150314,https://pubmed.ncbi.nlm.nih.gov/42442624/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42420267,FOXM1 inhibition primes terminal differentiation of human iPSC-derived hepatocytes.,2026,10.1038/s41420-026-03178-9,https://pubmed.ncbi.nlm.nih.gov/42420267/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42229414,"The heat shock transcription factor, HSF1, stimulates the catalytic engagement of topoisomerase IIβ over topoisomerase IIα.",2026,10.1016/j.molcel.2026.05.014,https://pubmed.ncbi.nlm.nih.gov/42229414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42755804,"The expression and clinical significance of SIRT5, H2A and TOP2A in cervical cancer.",2026,10.3389/fonc.2026.1899320,https://pubmed.ncbi.nlm.nih.gov/42755804/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,40425539,Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection.,2025,10.1038/s41467-025-60167-9,https://pubmed.ncbi.nlm.nih.gov/40425539/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42352983,Multifaceted Integrated Analysis of CDK1 and TOP2A Signaling Pathways for Multi-Target Therapeutic Intervention in Epithelial Ovarian Cancer.,2026,10.3390/ijms27125264,https://pubmed.ncbi.nlm.nih.gov/42352983/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42919848,Targeting Artemis sensitizes acute lymphoblastic leukemia cells to topoisomerase 2 poisons by disrupting DNA-PKcs-dependent repair.,2026,10.1038/s42003-026-10731-w,https://pubmed.ncbi.nlm.nih.gov/42919848/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42489567,Analysis of gene expression changes upon topobexin treatment and TOP2B-knockout in hiPSC-derived cardiomyocytes.,2026,10.1242/bio.062592,https://pubmed.ncbi.nlm.nih.gov/42489567/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42539873,Single-nucleus transcriptomics identifies cell cycle and synaptic pathway dysregulation during OPC-to-glioma progression.,2026,10.3389/fncel.2026.1713437,https://pubmed.ncbi.nlm.nih.gov/42539873/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42065042,"Integrated Global Phosphoproteomic, Bioinformatic, and Machine Learning Analysis Reveals Regulatory Networks of TOP1, TOP2A, TOP2B, and C1orf35 in Hepatocellular Carcinoma (HCC).",2026,10.32604/or.2026.073745,https://pubmed.ncbi.nlm.nih.gov/42065042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42465750,Targeting the E2F6-TOP2A-DKK1 axis: a novel therapeutic strategy for EMT-driven hepatocellular carcinoma progression.,2026,10.3389/fimmu.2026.1809952,https://pubmed.ncbi.nlm.nih.gov/42465750/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42827794,Integrating network analysis and machine learning to explore the pharmacological targets and associations of oleanolic acid in lung adenocarcinoma.,2026,10.3389/fphar.2026.1841232,https://pubmed.ncbi.nlm.nih.gov/42827794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42192880,TOP2 and NOS2 Orchestrate the Generation of DNA Breaks to Promote Colitis Cancer Initiation.,2026,10.3390/cancers18101519,https://pubmed.ncbi.nlm.nih.gov/42192880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,41296866,TOP2B modulates DNA supercoiling and chromatin contacts during transcriptional induction.,2025,10.1126/sciadv.adu6524,https://pubmed.ncbi.nlm.nih.gov/41296866/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,41284119,The analysis of TOP2A as a potential target for predicting the prognosis of brain glioma in the TCGA database and in single-center study.,2025,10.1007/s12672-025-04051-4,https://pubmed.ncbi.nlm.nih.gov/41284119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42869219,Determinants of Etoposide Hypersensitivity Span all of the Top2 alpha Catalytic Domains.,2026,10.1016/j.jmb.2026.170068,https://pubmed.ncbi.nlm.nih.gov/42869219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42675999,TOP2A Drives Oral Squamous Cell Carcinoma Initiation and Progression Through Activation of the TGF-β2/Smad Signaling Pathway.,2026,10.1111/jop.70178,https://pubmed.ncbi.nlm.nih.gov/42675999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,40803551,DNA Topoisomerase II Mutations in Cancer: Structural Impact and Drug Response in High-grade Serous Ovarian Carcinoma.,2026,10.1016/j.jmb.2025.169384,https://pubmed.ncbi.nlm.nih.gov/40803551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42106529,Identification of biomarkers associated with diagnosis of gastroesophageal junction adenocarcinoma and their correlation with immune infiltration.,2026,10.1007/s12672-026-05067-0,https://pubmed.ncbi.nlm.nih.gov/42106529/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42919937,Pharmacological correlates of topoisomerase II-directed protection against anthracycline-induced DNA damage and cardiotoxicity: a comparative evaluation of catalytic topoisomerase II inhibitors.,2026,10.1007/s00204-026-04600-y,https://pubmed.ncbi.nlm.nih.gov/42919937/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,41972142,Discovery of tumor antigens in renal cell carcinoma and prospects for clinical application.,2026,10.3389/fimmu.2026.1771006,https://pubmed.ncbi.nlm.nih.gov/41972142/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42794684,Virtual Screening and Molecular Dynamics Simulations Identifying Natural Product-Derived Cathepsin K Inhibitors as Potential Therapeutics for Osteoporosis.,2026,10.3390/ijms27188258,https://pubmed.ncbi.nlm.nih.gov/42794684/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42450107,In Silico Prioritisation of Similarity-Selected Small Molecules Targeting the IsdB NEAT Domain of &lt;i&gt;Staphylococcus aureus&lt;/i&gt; as a Potential Antivirulence Strategy.,2026,10.3390/ijms27135834,https://pubmed.ncbi.nlm.nih.gov/42450107/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,40969744,Immunoprevention of triple-negative breast cancer with a novel multivalent vaccine.,2025,10.3389/fimmu.2025.1638526,https://pubmed.ncbi.nlm.nih.gov/40969744/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42158873,"Case Report: triple therapy with pembrolizumab, ipilimumab, and lenvatinib in mitotane- and radiation-refractory, cortisol-secreting stage IV adrenocortical carcinoma: a genomically guided approach.",2026,10.3389/fimmu.2026.1819473,https://pubmed.ncbi.nlm.nih.gov/42158873/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,40873400,Exploring DNA topoisomerase II alpha in adrenocortical carcinoma through multi-omics analysis: a potential biomarker and therapeutic target.,2025,10.3724/abbs.2025144,https://pubmed.ncbi.nlm.nih.gov/40873400/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,39727717,Targeting TOP2A in Ovarian Cancer: Biological and Clinical Implications.,2024,10.3390/curroncol31120594,https://pubmed.ncbi.nlm.nih.gov/39727717/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,42140468,Computational multi-omics modelling identifies TOP2A as a central prognostic biomarker and therapeutic target in renal cell carcinoma.,2026,10.1016/j.abb.2026.110865,https://pubmed.ncbi.nlm.nih.gov/42140468/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,40887474,Single cell-RNA sequencing reveal TOP2A as a key driver of hepatocellular carcinoma progression.,2025,10.1038/s41598-025-16785-w,https://pubmed.ncbi.nlm.nih.gov/40887474/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TOP2A,ENSG00000131747,Unsafe,9155056,The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues.,1997,10.1038/bjc.1997.227,https://pubmed.ncbi.nlm.nih.gov/9155056/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,42778273,A general method for the assay of thiamine pyrophosphokinase activity.,2026,10.1016/bs.mie.2026.06.026,https://pubmed.ncbi.nlm.nih.gov/42778273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,42199240,The Regulatory Mechanism and Value in Early Diagnosis and Prognosis Assessment of miR-4448 in Breast Cancer.,2026,10.2147/bctt.s592003,https://pubmed.ncbi.nlm.nih.gov/42199240/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,42799968,HOM2 and TPK1 are associated with Kluyveromyces marxianus growth under high-temperature and reduced-aeration conditions.,2026,10.1007/s11274-026-05267-4,https://pubmed.ncbi.nlm.nih.gov/42799968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,42251905,Lactate-related diagnostic signature in rheumatoid arthritis: WGCNA and LASSO analysis with experimental validation.,2026,10.1016/j.imlet.2026.107200,https://pubmed.ncbi.nlm.nih.gov/42251905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,41506439,Astrocytic TPK1 mitigates amyloid pathology via TFEB-mediated endocytosis.,2026,10.1016/j.expneurol.2026.115640,https://pubmed.ncbi.nlm.nih.gov/41506439/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,42335246,TPK1-Related Thiamine Metabolism Dysfunction Syndrome,1993,,https://pubmed.ncbi.nlm.nih.gov/42335246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,39998251,Exploring the differential localization of protein kinase A isoforms in &lt;i&gt;Candida albicans&lt;/i&gt;.,2025,10.1128/msphere.01037-24,https://pubmed.ncbi.nlm.nih.gov/39998251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,40427372,The Molecular Mechanism by Which miR-211-5p Regulates the Proliferation and Differentiation of Preadipocytes in Meat Rabbits by Targeting TPK1.,2025,10.3390/ani15101497,https://pubmed.ncbi.nlm.nih.gov/40427372/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,40299682,Thiamine and METTL14 in Diabetes Management with Intensive Insulin Therapy.,2025,10.3390/biomedicines13040980,https://pubmed.ncbi.nlm.nih.gov/40299682/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,42837982,AtCAMTA4 negatively regulates salinity stress response via regulation of ROS and Na&lt;sup&gt;+&lt;/sup&gt;/K&lt;sup&gt;+&lt;/sup&gt; homeostasis.,2026,10.1016/j.plaphy.2026.111807,https://pubmed.ncbi.nlm.nih.gov/42837982/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,39844397,Integrative Bioinformatics and Experimental Validation Reveal the Mechanistic Action of Patchouli Alcohol in Prostate Cancer Treatment.,2026,10.2174/0113892010355513241224101450,https://pubmed.ncbi.nlm.nih.gov/39844397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,40361616,Engineering Baker's Yeast for Efficient cAMP Synthesis via Regulation of PKA Activity.,2025,10.3390/foods14091533,https://pubmed.ncbi.nlm.nih.gov/40361616/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,41375369,Cloning and Functional Verification of Salt Tolerance Gene &lt;i&gt;HbNHX2&lt;/i&gt; in &lt;i&gt;Hordeum brevisubulatum&lt;/i&gt;.,2025,10.3390/plants14233658,https://pubmed.ncbi.nlm.nih.gov/41375369/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,41400924,Nonredundant roles for paralogous proteins in the yeast glucose-sensing pathway.,2026,10.1091/mbc.e25-10-0475,https://pubmed.ncbi.nlm.nih.gov/41400924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,39140381,Report of a novel recurrent homozygous variant c.620A&gt;T in three unrelated families with thiamine metabolism dysfunction syndrome 5 and review of literature.,2024,10.1097/mcd.0000000000000490,https://pubmed.ncbi.nlm.nih.gov/39140381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,40225937,Novel Synonymous and Deep Intronic Variants Causing Primary and Secondary Pyruvate Dehydrogenase Complex Deficiency.,2024,10.1155/2024/1611838,https://pubmed.ncbi.nlm.nih.gov/40225937/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,40838017,Multi-omics reveals effects of diet FNDF/starch level on growth performance and rumen development of Hu sheep.,2025,10.3389/fmicb.2025.1601950,https://pubmed.ncbi.nlm.nih.gov/40838017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,40300504,Plasma proteomic profiling reveals Parkinson's disease-associated proteins: A UK Biobank study.,2025,10.1016/j.parkreldis.2025.107851,https://pubmed.ncbi.nlm.nih.gov/40300504/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,41158885,Novel Insights From In Silico Analysis of Biallelic ALPL (c.1001G/A and c.571G/A) in Two Mennonite Families Leading to Hypophosphatasia.,2025,10.7759/cureus.93139,https://pubmed.ncbi.nlm.nih.gov/41158885/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,40186230,The wide phenotypic spectrum of thiamine metabolism dysfunction syndrome 5 and its treatment.,2025,10.1186/s13023-025-03665-9,https://pubmed.ncbi.nlm.nih.gov/40186230/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,41299220,Multiomic analyses on the contribution of transposable elements to the cis-regulatory landscape of different types of immune cells.,2025,10.1186/s12864-025-12285-3,https://pubmed.ncbi.nlm.nih.gov/41299220/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,40593068,Predicting cisplatin response in cholangiocarcinoma patients using chromosome pattern and related gene expression.,2025,10.1038/s41598-025-06851-8,https://pubmed.ncbi.nlm.nih.gov/40593068/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,37375824,Chlorogenic Acid Induced Neuroblastoma Cells Differentiation via the ACAT1-TPK1-PDH Pathway.,2023,10.3390/ph16060877,https://pubmed.ncbi.nlm.nih.gov/37375824/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,38730464,Multiomics-based molecular subtyping based on the commensal microbiome predicts molecular characteristics and the therapeutic response in breast cancer.,2024,10.1186/s12943-024-02017-8,https://pubmed.ncbi.nlm.nih.gov/38730464/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,41443473,Whole-genome sequencing identifies genetic diversity and adaptive signatures of hypoxia and ultraviolet radiation in Chinese chickens.,2026,10.1016/j.jare.2025.12.027,https://pubmed.ncbi.nlm.nih.gov/41443473/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,37622082,Thiamine pyrophosphokinase deficiency: report of two Chinese cases and a literature review.,2023,10.3389/fped.2023.1173787,https://pubmed.ncbi.nlm.nih.gov/37622082/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,37760005,Protein Kinase A Controls the Melanization of Candida auris through the Alteration of Cell Wall Components.,2023,10.3390/antiox12091702,https://pubmed.ncbi.nlm.nih.gov/37760005/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,41358723,Mitochondrial complex III subunit Qcr8 regulates the virulence and adhesion of &lt;i&gt;Candida albicans&lt;/i&gt; by modulating mitochondrial function.,2026,10.1128/spectrum.01672-25,https://pubmed.ncbi.nlm.nih.gov/41358723/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,37306828,A demonstration based on multi-omics transcriptome sequencing data revealed disulfidptosis heterogeneity within the tumor microenvironment of esophageal squamous cell carcinoma.,2023,10.1007/s12672-023-00711-5,https://pubmed.ncbi.nlm.nih.gov/37306828/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,37415797,Effect of genetic variants in UBE2O and TPK1 on facial morphology of Koreans.,2023,10.1093/fsr/owad011,https://pubmed.ncbi.nlm.nih.gov/37415797/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,36543778,Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation.,2022,10.1038/s41467-022-35388-x,https://pubmed.ncbi.nlm.nih.gov/36543778/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,30459934,The adaptive regulation of thiamine pyrophosphokinase-1 facilitates malignant growth during supplemental thiamine conditions.,2018,10.18632/oncotarget.26259,https://pubmed.ncbi.nlm.nih.gov/30459934/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,36879823,Functional genomic analysis of &lt;i&gt;Candida albicans&lt;/i&gt; protein kinases reveals modulators of morphogenesis in diverse environments.,2023,10.1016/j.isci.2023.106145,https://pubmed.ncbi.nlm.nih.gov/36879823/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,35883514,Yeast Protein Kinase A Isoforms: A Means of Encoding Specificity in the Response to Diverse Stress Conditions?,2022,10.3390/biom12070958,https://pubmed.ncbi.nlm.nih.gov/35883514/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,11342117,Molecular cloning of human thiamin pyrophosphokinase.,2001,10.1016/s0167-4781(00)00264-5,https://pubmed.ncbi.nlm.nih.gov/11342117/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPK1,ENSG00000196511,Unsafe,11342111,Isolation and characterization of a human thiamine pyrophosphokinase cDNA.,2001,10.1016/s0167-4781(00)00247-5,https://pubmed.ncbi.nlm.nih.gov/11342111/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPPP2,ENSG00000179636,Unsafe,41148789,Diverse Roles of Tubulin Polymerization Promoting Protein 3 (TPPP3) in Human Health and Disease.,2025,10.3390/cells14201573,https://pubmed.ncbi.nlm.nih.gov/41148789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPPP2,ENSG00000179636,Unsafe,39000129,The Role of Tubulin Polymerization-Promoting Protein2 (TPPP2) in Spermatogenesis: A Narrative Review.,2024,10.3390/ijms25137017,https://pubmed.ncbi.nlm.nih.gov/39000129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPPP2,ENSG00000179636,Unsafe,42826827,Perfluorooctanoic acid exposure inhibits round spermatid elongation by impeding ubiquitin-proteasome-mediated chromatin remodeling in mice.,2026,10.1016/j.tox.2026.154608,https://pubmed.ncbi.nlm.nih.gov/42826827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPPP2,ENSG00000179636,Unsafe,36950598,Gene-based cancer-testis antigens as prognostic indicators in hepatocellular carcinoma.,2023,10.1016/j.heliyon.2023.e13269,https://pubmed.ncbi.nlm.nih.gov/36950598/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPPP2,ENSG00000179636,Unsafe,40041504,Identification of reproductive performance in Bali-polled bulls using computer-assisted semen analysis and plasma seminal proteomics.,2025,10.14202/vetworld.2025.102-109,https://pubmed.ncbi.nlm.nih.gov/40041504/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPPP2,ENSG00000179636,Unsafe,30680919,"Deficiency of TPPP2, a factor linked to oligoasthenozoospermia, causes subfertility in male mice.",2019,10.1111/jcmm.14149,https://pubmed.ncbi.nlm.nih.gov/30680919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPPP2,ENSG00000179636,Unsafe,37782577,"Bull Sperm SWATH-MS-Based Proteomics Reveals Link between High Fertility and Energy Production, Motility Structures, and Sperm-Oocyte Interaction.",2023,10.1021/acs.jproteome.3c00461,https://pubmed.ncbi.nlm.nih.gov/37782577/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPPP2,ENSG00000179636,Unsafe,37549510,Integrated molecular-network analysis reveals infertility-associated key genes and transcription factors in the non-obstructive azoospermia.,2023,10.1016/j.ejogrb.2023.07.023,https://pubmed.ncbi.nlm.nih.gov/37549510/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPPP2,ENSG00000179636,Unsafe,34231842,CFAP65 is required in the acrosome biogenesis and mitochondrial sheath assembly during spermiogenesis.,2021,10.1093/hmg/ddab185,https://pubmed.ncbi.nlm.nih.gov/34231842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPPP2,ENSG00000179636,Unsafe,30820981,Comparative proteomic analysis of high- and low-fertile buffalo bull spermatozoa for identification of fertility-associated proteins.,2019,10.1111/rda.13426,https://pubmed.ncbi.nlm.nih.gov/30820981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPPP2,ENSG00000179636,Unsafe,33292187,A systems biology framework integrating GWAS and RNA-seq to shed light on the molecular basis of sperm quality in swine.,2020,10.1186/s12711-020-00592-0,https://pubmed.ncbi.nlm.nih.gov/33292187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPPP2,ENSG00000179636,Unsafe,36277216,Quantitative phosphoproteomics analyses reveal the regulatory mechanisms related to frozen-thawed sperm capacitation and acrosome reaction in yak (Bos grunniens).,2022,10.3389/fphys.2022.1013082,https://pubmed.ncbi.nlm.nih.gov/36277216/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPPP2,ENSG00000179636,Unsafe,23436708,Scanning of novel cancer/testis proteins by human testis proteomic analysis.,2013,10.1002/pmic.201200489,https://pubmed.ncbi.nlm.nih.gov/23436708/,annotation citations | normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPPP2,ENSG00000179636,Unsafe,25576359,On the tubulin polymerization promoting proteins of zebrafish.,2015,10.1016/j.bbrc.2014.12.099,https://pubmed.ncbi.nlm.nih.gov/25576359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPPP2,ENSG00000179636,Unsafe,28106390,Tubulin Binding and Polymerization Promoting Properties of Tubulin Polymerization Promoting Proteins Are Evolutionarily Conserved.,2017,10.1021/acs.biochem.6b00902,https://pubmed.ncbi.nlm.nih.gov/28106390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPPP2,ENSG00000179636,Unsafe,22711244,Genetic architecture of resilience of executive functioning.,2012,10.1007/s11682-012-9184-1,https://pubmed.ncbi.nlm.nih.gov/22711244/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,42473588,Targeting TPX2 to Enhance Metastasis Control and Radiosensitivity in Esophageal Squamous Cell Carcinoma Through PI3K/AKT Pathway Modulation.,2026,10.30498/ijb.2025.549444.4243,https://pubmed.ncbi.nlm.nih.gov/42473588/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,42311261,TPX2-mediated autophagy maintains cancer stemness in LUAD: bioinformatic screening and functional validation.,2026,10.3389/fonc.2026.1724797,https://pubmed.ncbi.nlm.nih.gov/42311261/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,42594498,CircLDLR silencing alleviates the damage of keratinocytes induced by M5 cytokine via the miR-1294/TPX2 axis.,2026,10.1016/j.tice.2026.103856,https://pubmed.ncbi.nlm.nih.gov/42594498/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,41768250,TPX2 promotes gastric cancer progression and angiogenesis via Wnt/β-catenin signaling.,2026,10.3389/fonc.2026.1764583,https://pubmed.ncbi.nlm.nih.gov/41768250/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,42199350,TPX2 as a prognostic biomarker and potential therapeutic target for malignant melanoma proliferation and metastasis.,2026,10.3892/etm.2026.13177,https://pubmed.ncbi.nlm.nih.gov/42199350/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,42794412,&lt;i&gt;Arabidopsis&lt;/i&gt; TPXL Proteins Mediate a Selective Aurora Kinase-Microtubule Association During Cell Division.,2026,10.3390/ijms27187980,https://pubmed.ncbi.nlm.nih.gov/42794412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,42148505,RBM15B-mediated m6A modification of FOXM1 activates the AURKA/TPX2 axis to promote epithelial-mesenchymal transition-driven endometrial cancer progression.,2026,10.1080/19336918.2026.2674357,https://pubmed.ncbi.nlm.nih.gov/42148505/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,42331884,Transcriptomic landscape of Gallbladder cancer reveals altered pathways related to cell cycle and Aurora kinase.,2026,10.1038/s41598-026-55515-8,https://pubmed.ncbi.nlm.nih.gov/42331884/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,41740229,Somatic structural variants drive upper tract urothelial carcinoma muscle invasiveness via activation of TPX2 transcription.,2026,10.1016/j.ebiom.2026.106182,https://pubmed.ncbi.nlm.nih.gov/41740229/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,42106529,Identification of biomarkers associated with diagnosis of gastroesophageal junction adenocarcinoma and their correlation with immune infiltration.,2026,10.1007/s12672-026-05067-0,https://pubmed.ncbi.nlm.nih.gov/42106529/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,41617029,CEP55 promotes prostate cancer progression via TPX2-dependent activation of AURKA-PI3K-AKT signaling and inhibition of ferroptosis.,2026,10.1016/j.jbc.2026.111218,https://pubmed.ncbi.nlm.nih.gov/41617029/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,41113174,Overexpression of the TPX2 gene is associated with enhanced tumor malignancy in lung adenocarcinoma and identification of marine natural inhibitors of the Aurora kinase A-TPX2 protein complex.,2025,10.1007/s40203-025-00436-z,https://pubmed.ncbi.nlm.nih.gov/41113174/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,41923619,Targeting TPX2-dependent lineage plasticity by CDK4/6 inhibition reverses therapy resistance in neuroendocrine bladder carcinoma.,2026,10.1016/j.xcrm.2026.102712,https://pubmed.ncbi.nlm.nih.gov/41923619/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,41144123,"Integrated transcriptomic and immunoinformatics analysis identifies tpx2, bub1b, and ube2c as diagnostic biomarkers and therapeutic targets in endometrial carcinoma.",2025,10.1007/s12672-025-03800-9,https://pubmed.ncbi.nlm.nih.gov/41144123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,42131338,Evaluation of translational potential of mRNA vaccine candidate antigens for pancreatic cancer: a systematic review based on clinical evidence and stratified prioritization strategies.,2026,10.3389/fimmu.2026.1803792,https://pubmed.ncbi.nlm.nih.gov/42131338/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,42035943,CDT1 and E2F1 synergistically promote the glycolysis and progression of non-small cell lung cancer through the TPX2/AKT pathway.,2026,10.1016/j.ejphar.2026.178892,https://pubmed.ncbi.nlm.nih.gov/42035943/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,42726806,Identification of functional genes and immune cell infiltration analysis in liposarcoma.,2026,10.1371/journal.pone.0358180,https://pubmed.ncbi.nlm.nih.gov/42726806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,42405025,Integrative Transcriptomic Analysis Identifies Hypoxia-responsive Cell Cycle Hub Genes as Prognostic Markers in Glioblastoma.,2026,10.1177/09727531261453688,https://pubmed.ncbi.nlm.nih.gov/42405025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,41811178,Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations.,2026,10.7554/elife.100832,https://pubmed.ncbi.nlm.nih.gov/41811178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,42420840,Single-cell and bulk transcriptomics identify senescence-related EMT transcriptional programs and a prognostic framework in pancreatic ductal adenocarcinoma.,2026,10.1186/s12876-026-05043-6,https://pubmed.ncbi.nlm.nih.gov/42420840/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,41836411,Deciphering immune heterogeneity in lung adenocarcinoma via machine learning-based Differential Phenotype Immune Score: TPX2 as a key biomarker for immunotherapy resistance.,2026,10.3389/fimmu.2026.1797282,https://pubmed.ncbi.nlm.nih.gov/41836411/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,41876446,The ATC12 small molecule inhibits the Aurora-A/TPX2 interaction and impairs the proliferation of breast cancer cells.,2026,10.1038/s41419-026-08579-3,https://pubmed.ncbi.nlm.nih.gov/41876446/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,41054421,Integrated multi-omics analysis identifies TPX2 as a potential prognostic and immunological biomarker in hepatocellular carcinoma.,2025,10.1016/j.iliver.2025.100184,https://pubmed.ncbi.nlm.nih.gov/41054421/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,39688710,Exploring the clinical significance of TPX2 in pancreatic cancer: from biomarker to immunotherapy.,2025,10.1007/s00210-024-03628-0,https://pubmed.ncbi.nlm.nih.gov/39688710/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,41178031,HMSN-Mediated miR-502-3p Delivery Suppresses Lung Adenocarcinoma via TPX2-Dependent Inhibition of PI3K/AKT.,2025,10.1021/acsbiomaterials.5c01555,https://pubmed.ncbi.nlm.nih.gov/41178031/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,40837835,Green-synthesized silver nanoparticles from incensole acetate modulate &lt;i&gt;TPX2&lt;/i&gt; expression in DMBA-induced breast cancer.,2025,10.1039/d5na00341e,https://pubmed.ncbi.nlm.nih.gov/40837835/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,42037647,Prognostic biomarkers and regulatory mechanisms associated with lysine β-hydroxybutyrylation modification in prostate cancer.,2026,10.3389/fmolb.2026.1778536,https://pubmed.ncbi.nlm.nih.gov/42037647/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,40695191,Deciphering the prognostic value and immunotherapeutic strategy of aggrephagy in melanoma: Integrating single-cell sequencing and machine learning.,2025,10.1016/j.seminoncol.2025.152371,https://pubmed.ncbi.nlm.nih.gov/40695191/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TPX2,ENSG00000088325,Unsafe,42438784,SPP1+ Macrophages Promote Immunosuppression in Post-TACE Hepatocellular Carcinoma Involving Lactate-Induced Lactylation and Potential SPP1-CD44 Signaling.,2026,10.2147/jhc.s603485,https://pubmed.ncbi.nlm.nih.gov/42438784/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC5,ENSG00000181029,Unsafe,35425722,MCT4 Promotes Hepatocellular Carcinoma Progression by Upregulating TRAPPC5 Gene.,2022,10.2147/jhc.s352948,https://pubmed.ncbi.nlm.nih.gov/35425722/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC5,ENSG00000181029,Unsafe,32151258,Long noncoding RNA and messenger RNA abnormalities in pediatric sepsis: a preliminary study.,2020,10.1186/s12920-020-0698-x,https://pubmed.ncbi.nlm.nih.gov/32151258/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC5,ENSG00000181029,Unsafe,35401685,Genetic Parameter Estimation and Whole Sequencing Analysis of the Genetic Architecture of Chicken Keel Bending.,2022,10.3389/fgene.2022.833132,https://pubmed.ncbi.nlm.nih.gov/35401685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC5,ENSG00000181029,Unsafe,24929516,[Differentially expressed genes identified in the main olfactory epithelium of mice with deficiency of adenylate cyclase 3 by using suppression subtractive hybridization approach].,2014,10.3724/sp.j.1005.2014.0574,https://pubmed.ncbi.nlm.nih.gov/24929516/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,42417464,Expanding the Phenotypic Spectrum of Trafficking Protein Particle Complex Subunit 9-Related Intellectual Developmental Disorder: Prader-Willi-like Presentation in a Tunisian Family.,2026,10.1177/19450265261468940,https://pubmed.ncbi.nlm.nih.gov/42417464/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,42910280,Hypoxia Reprograms a Ciliary Scaffold into a Metabolic-Epigenetic Trafficking Hub via a Succinate-Driven DNMT3L-ASXL2 Axis.,2026,10.7150/ijbs.137355,https://pubmed.ncbi.nlm.nih.gov/42910280/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,42353817,&lt;i&gt;TRAPPC9&lt;/i&gt;-Related Intellectual Developmental Disorder: A Systematic Review and a Novel Case of a Complex Structural Variant.,2026,10.3390/genes17060658,https://pubmed.ncbi.nlm.nih.gov/42353817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,41300827,Canine Neuronal Ceroid Lipofuscinosis-like Disorder Associated with Sequence Variants in &lt;i&gt;AP3B1&lt;/i&gt; and &lt;i&gt;TRAPPC9&lt;/i&gt;.,2025,10.3390/genes16111370,https://pubmed.ncbi.nlm.nih.gov/41300827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,37416774,Defective neurite elongation and branching in Nibp/Trappc9 deficient zebrafish and mice.,2023,10.7150/ijbs.78489,https://pubmed.ncbi.nlm.nih.gov/37416774/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,38889014,Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in Trappc9-linked brain developmental syndrome.,2024,10.1172/jci.insight.181339,https://pubmed.ncbi.nlm.nih.gov/38889014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,41981918,Diagnostic Accuracy of Arm Conicity to Detect Inaccurate Non-Invasive Blood Pressure Measurement in Obese Patients.,2026,10.1111/aas.70236,https://pubmed.ncbi.nlm.nih.gov/41981918/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,41613331,Diagnostic accuracy of the HUAWEI WATCH D for measuring spinal anesthesia-induced hypotension during elective cesarean section: a diagnostic test.,2025,10.3389/fmed.2025.1686637,https://pubmed.ncbi.nlm.nih.gov/41613331/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,42645425,Correlation of AHR Activation-Induced Suppression of PWM-Stimulated IgG and IgG-Triggered Signaling in Human PBMCs.,2026,10.3390/antib15040068,https://pubmed.ncbi.nlm.nih.gov/42645425/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,42691834,Agreement between noninvasive blood pressure obtained by an automated oscillometric blood pressure monitor and invasive blood pressure measurements in anesthetized pumas (Puma concolor).,2026,10.1016/j.vaa.2026.101296,https://pubmed.ncbi.nlm.nih.gov/42691834/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,39045327,DNA methylation patterns in the peripheral blood of Xinjiang brown cattle with variable somatic cell counts.,2024,10.3389/fgene.2024.1405478,https://pubmed.ncbi.nlm.nih.gov/39045327/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,41402726,Comparison of invasive and noninvasive blood pressure measurements in critically ill patients receiving norepinephrine.,2025,10.1186/s12871-025-03502-3,https://pubmed.ncbi.nlm.nih.gov/41402726/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,32434006,Emerging role of NIK/IKK2-binding protein (NIBP)/trafficking protein particle complex 9 (TRAPPC9) in nervous system diseases.,2020,10.1016/j.trsl.2020.05.001,https://pubmed.ncbi.nlm.nih.gov/32434006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,41350911,Beyond global trueness and precision: evaluating the clinical suitability of automated brachial cuff blood pressure measurements in acute care-a protocol for systematic review and meta-analysis of aggregated and individual participant data.,2025,10.1186/s13643-025-03009-5,https://pubmed.ncbi.nlm.nih.gov/41350911/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,40976028,Noninvasive blood pressure measurements demonstrated a significant underestimation of blood pressure in a patient with severe preeclampsia: a case report.,2025,10.1016/j.ijscr.2025.111956,https://pubmed.ncbi.nlm.nih.gov/40976028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,39184350,Case Report: Whole exome sequencing identifies compound heterozygous variants in the TRAPPC9 gene in a child with developmental delay.,2024,10.3389/fgene.2024.1415194,https://pubmed.ncbi.nlm.nih.gov/39184350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,42768427,EXPRESS: EFFECTS OF INTRAMUSCULAR AND INTRANASAL ADMINISTRATION OF MEDETOMIDINE ON SEDATION AND SOME CARDIOPULMONARY VARIABLES IN HEALTHY CATS.,2026,10.1177/1098612x261493783,https://pubmed.ncbi.nlm.nih.gov/42768427/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,38058760,TRAPPC9-Related Intellectual Disability: Report of Two New Cases and Review of the Literature.,2023,10.1159/000531439,https://pubmed.ncbi.nlm.nih.gov/38058760/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,40284851,Evaluation of Two Veterinary Oscillometric Noninvasive Blood Pressure (NIBP) Measurement Devices (petMAP Graphic II and High-Definition Oscillometry) in Dogs.,2025,10.3390/vetsci12040349,https://pubmed.ncbi.nlm.nih.gov/40284851/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,39261946,Overexpression of ZFP69B promotes hepatocellular carcinoma growth by upregulating the expression of TLX1 and TRAPPC9.,2024,10.1186/s13008-024-00131-z,https://pubmed.ncbi.nlm.nih.gov/39261946/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,42277673,Automated alerts and intraoperative noninvasive blood pressure monitoring gaps: a retrospective before-and-after study.,2026,10.1186/s12871-026-04023-3,https://pubmed.ncbi.nlm.nih.gov/42277673/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,42388985,Accuracy of ankle versus arm oscillometric non-invasive blood pressure in detecting hypotension during shoulder surgery in the beach-chair position: A prospective observational study.,2026,10.4103/ija.ija_251_26,https://pubmed.ncbi.nlm.nih.gov/42388985/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,39998635,Continuous immunotherapy beyond disease progression in patients with advanced non-small cell and small cell lung cancer.,2025,10.1007/s00262-025-03958-9,https://pubmed.ncbi.nlm.nih.gov/39998635/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,42358569,Reduction of fentanyl-induced cough by low-dose nalbuphine pretreatment during induction of general anesthesia in children: a randomized controlled trial.,2026,10.3389/fped.2026.1795451,https://pubmed.ncbi.nlm.nih.gov/42358569/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,42654383,The Effect of Using Hypotension Prediction Index to Reduce Intraoperative Hypotension in Elective Cesarean Sections: A Randomized Controlled Trial.,2026,10.3390/medicina62081486,https://pubmed.ncbi.nlm.nih.gov/42654383/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,42275671,The Effect of Education Through Interactive Videos on Noninvasive Blood Pressure Measurement Knowledge and Skill Level of Nursing Students.,2026,10.1097/cin.0000000000001582,https://pubmed.ncbi.nlm.nih.gov/42275671/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,40725744,Feasibility of Hypotension Prediction Index-Guided Monitoring for Epidural Labor Analgesia: A Randomized Controlled Trial.,2025,10.3390/jcm14145037,https://pubmed.ncbi.nlm.nih.gov/40725744/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,40256648,Systolic Pressure and Pulse Rate Range Performance Comparison of Seven Non-Invasive Blood Pressure Monitors.,2025,10.2147/mder.s520615,https://pubmed.ncbi.nlm.nih.gov/40256648/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,42367153,Impact of Inhalation Sedation on Cardiovascular Haemodynamics in Hypertensive Patients Requiring Dental Treatment: A Clinical Observational Study.,2026,10.3290/j.ohpd.c_2753,https://pubmed.ncbi.nlm.nih.gov/42367153/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,40072565,Development and evaluation of an automated phenylephrine delivery system by lower limit control for managing intraoperative hypotension.,2025,10.1007/s00540-025-03476-z,https://pubmed.ncbi.nlm.nih.gov/40072565/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,38321507,"Continuous vs intermittent Non-Invasive blood pressure MONitoring in preventing postoperative organ failure (niMON): study protocol for an open-label, multicenter randomized trial.",2024,10.1186/s44158-024-00142-w,https://pubmed.ncbi.nlm.nih.gov/38321507/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRAPPC9,ENSG00000167632,Unsafe,15951441,"NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation.",2005,10.1074/jbc.m501670200,https://pubmed.ncbi.nlm.nih.gov/15951441/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,42637077,TRDMT1 slows lung cancer growth by stabilizing TFRC mRNA and triggering ferroptosis cell death.,2026,10.1016/j.jbc.2026.113474,https://pubmed.ncbi.nlm.nih.gov/42637077/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,42901998,"A multi-omics study integrating single-cell transcriptomics, spatial transcriptomics, and mendelian randomization unveil the implication of TRDMT1 expression in T cells on the immunotherapeutic response and prognosis in breast cancer.",2026,10.1007/s10142-026-02083-9,https://pubmed.ncbi.nlm.nih.gov/42901998/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,40905999,Transfer RNA Aspartic Acid Methyltransferase 1 (TRDMT1/DNMT2) Regulates Plant Development and Gene Expression in the Moss Physcomitrium patens.,2025,10.1007/s00438-025-02285-z,https://pubmed.ncbi.nlm.nih.gov/40905999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,42706250,Suppression of transcription-replication conflicts by sequence-coordinated actions of TRDMT1 and MutLα.,2026,10.1038/s41467-026-76137-8,https://pubmed.ncbi.nlm.nih.gov/42706250/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,42431391,TRDMT1-mediated mRNA m&lt;sup&gt;5&lt;/sup&gt;C methylation decreases chemotherapy sensitivity by activating homologous recombination-mediated DNA damage repair and IRS2 expression in pancreatic cancer.,2026,10.1016/j.canlet.2026.218725,https://pubmed.ncbi.nlm.nih.gov/42431391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,41723159,DNMT2 inhibits anaplastic thyroid cancer progression by downregulating 5'tiRNA&lt;sup&gt;Gly-GCC&lt;/sup&gt; production.,2026,10.1038/s41419-026-08488-5,https://pubmed.ncbi.nlm.nih.gov/41723159/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,42580142,TRDMT1-dependent m5C modification of TLR4 mediates the protective effects of Shaoyao decoction in TNBS-induced Crohn's disease.,2026,10.1016/j.intimp.2026.117233,https://pubmed.ncbi.nlm.nih.gov/42580142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,40894903,DNA-encoded library screening uncovers potent DNMT2 inhibitors targeting a cryptic allosteric binding site.,2025,10.1016/j.isci.2025.113300,https://pubmed.ncbi.nlm.nih.gov/40894903/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,38782147,Biological function molecular pathways and druggability of DNMT2/TRDMT1.,2024,10.1016/j.phrs.2024.107222,https://pubmed.ncbi.nlm.nih.gov/38782147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,39617358,tRNA methyltransferase DNMT2 promotes hepatocellular carcinoma progression and enhances Bortezomib resistance through inhibiting TNFSF10.,2025,10.1016/j.cellsig.2024.111533,https://pubmed.ncbi.nlm.nih.gov/39617358/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,41226543,DNMT Enzymes and Their Impact on Cervical Cancer: A State-of-the-Art Review.,2025,10.3390/ijms262110496,https://pubmed.ncbi.nlm.nih.gov/41226543/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,41417568,DNMT2-m5C-ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation-Mediated Notch Pathway.,2026,10.1002/advs.202515931,https://pubmed.ncbi.nlm.nih.gov/41417568/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,41790613,An integrative analysis reveals the mechanism of plastic stabilizers inducing breast cancer.,2026,10.1371/journal.pcbi.1014025,https://pubmed.ncbi.nlm.nih.gov/41790613/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,40984038,Association of TRDMT1 Gene Polymorphisms With Neuroblastoma Susceptibility: Insights From a Case-Control Study.,2025,10.1111/jcmm.70848,https://pubmed.ncbi.nlm.nih.gov/40984038/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,40754087,Resveratrol alleviates lipopolysaccharide-induced acute lung injury through blocking the excessive autophagy/mitophagy via SIRT1/PGC-1α and TNF/NF-κB/JNK pathways.,2025,10.1016/j.ijbiomac.2025.146500,https://pubmed.ncbi.nlm.nih.gov/40754087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,37584564,Arabidopsis T-DNA mutants affected in TRDMT1/DNMT2 show differential protein synthesis and compromised stress tolerance.,2024,10.1111/febs.16935,https://pubmed.ncbi.nlm.nih.gov/37584564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,37579906,Restricted tRNA methylation by intermolecular disulfide bonds in DNMT2/TRDMT1.,2023,10.1016/j.ijbiomac.2023.126310,https://pubmed.ncbi.nlm.nih.gov/37579906/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,37966982,Determinants of DNMT2/TRDMT1 preference for substrates tRNA and DNA during the evolution.,2023,10.1080/15476286.2023.2272473,https://pubmed.ncbi.nlm.nih.gov/37966982/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,41519051,Unveiling the landscape of m&lt;sup&gt;5&lt;/sup&gt;C RNA methylation in lung cancer: From molecular mechanisms to therapeutic opportunities.,2026,10.1016/j.bbrc.2026.153259,https://pubmed.ncbi.nlm.nih.gov/41519051/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,39630363,The mechanism of sevoflurane affecting ovarian cancer cell proliferation and migration by regulating RNA methylase TRDMT1 to activate the β-catenin pathway.,2024,10.1007/s10565-024-09941-x,https://pubmed.ncbi.nlm.nih.gov/39630363/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,40801921,TRDMT1 methyltransferase gene knockout attenuates STING-based cell death signaling during self-extracellular RNA-mediated response in drug-induced senescent osteosarcoma cells.,2025,10.1007/s00018-025-05835-1,https://pubmed.ncbi.nlm.nih.gov/40801921/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,42154051,Geroprotective effects of bioactive compounds against hydroquinone toxicity in Drosophila melanogaster: an in vivo and in silico insight.,2026,10.1007/s10522-026-10452-x,https://pubmed.ncbi.nlm.nih.gov/42154051/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,36273376,DNMT2/TRDMT1 gene knockout compromises doxorubicin-induced unfolded protein response and sensitizes cancer cells to ER stress-induced apoptosis.,2023,10.1007/s10495-022-01779-0,https://pubmed.ncbi.nlm.nih.gov/36273376/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,34139673,The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence.,2021,10.18632/aging.203203,https://pubmed.ncbi.nlm.nih.gov/34139673/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,34110975,New substrates and determinants for tRNA recognition of RNA methyltransferase DNMT2/TRDMT1.,2021,10.1080/15476286.2021.1930756,https://pubmed.ncbi.nlm.nih.gov/34110975/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,39923561,Molecular insight into reproductive toxicity and transgenerational effects of Cadmium exposure on Drosophila melanogaster.,2025,10.1016/j.ecoenv.2025.117870,https://pubmed.ncbi.nlm.nih.gov/39923561/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,41350058,Acute insecticide exposure uncovers genotype-specific transcriptomic responses underlying toxicity and resistance in mosquitoes.,2026,10.1016/j.pestbp.2025.106799,https://pubmed.ncbi.nlm.nih.gov/41350058/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,40235543,Exploring the impact of cuproptosis on prostate cancer prognosis &lt;i&gt;via&lt;/i&gt; RNA methylation regulation based on single cell and bulk RNA sequencing data.,2025,10.3389/fphar.2025.1573611,https://pubmed.ncbi.nlm.nih.gov/40235543/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRDMT1,ENSG00000107614,Unsafe,42084676,"RNA methylation in cardiovascular remodeling: Molecular mechanisms, biomarkers, and therapeutic strategies.",2026,10.1007/s11033-026-11865-0,https://pubmed.ncbi.nlm.nih.gov/42084676/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,42559952,Molecular Mechanism of TRIM16 Regulating Osteogenic Differentiation of Periodontal Ligament Stem Cells Under Inflammatory Microenvironment.,2026,10.1002/cbin.70192,https://pubmed.ncbi.nlm.nih.gov/42559952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,41717414,"TRIM16: a context-dependent E3 ligase in autophagy, oxidative stress, and immune regulation - from cancer and systemic disease.",2026,10.3389/fonc.2026.1743345,https://pubmed.ncbi.nlm.nih.gov/41717414/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,42580143,Tripartite motif 16 mitigates endotoxemia-induced cardiac dysfunction via the Cav-1/Src/YAP signaling axis in mice.,2026,10.1016/j.intimp.2026.117274,https://pubmed.ncbi.nlm.nih.gov/42580143/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,42831895,ZC3H13-Mediated m&lt;sup&gt;6&lt;/sup&gt;A Modification of TRIM16 Suppresses EndMT and Atherosclerosis by Destabilizing Ang2 and Inhibiting the TLR4/NLRP3 Pathway.,2026,10.1080/10985549.2026.2733731,https://pubmed.ncbi.nlm.nih.gov/42831895/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,42171628,FGF8-mediated TRIM16 regulation promotes K48-linked ubiquitination and degradation of RIG-I to facilitate Influenza a virus immune evasion.,2026,10.1080/21505594.2026.2677346,https://pubmed.ncbi.nlm.nih.gov/42171628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,41134044,TRIM16 Inhibits Inflammation by Interacting With and Ubiquitinating TRAF2 in a Colitis Model.,2025,10.1111/jcmm.70917,https://pubmed.ncbi.nlm.nih.gov/41134044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,40990506,Sanggenol L Enhances Temozolomide Drug Sensitivity by Inhibiting Mitophagy and Inducing Apoptosis Through the Regulation of the TRIM16-OPTN Axis in Glioblastoma.,2025,10.1002/advs.202502915,https://pubmed.ncbi.nlm.nih.gov/40990506/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,41437125,TRIM16 mediates YAP1 K63-linked ubiquitination to alleviate sepsis-induced acute liver injury through YAP/Nrf2 axis in mice.,2025,10.1186/s13578-025-01517-4,https://pubmed.ncbi.nlm.nih.gov/41437125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,42107085,ZDHHC18-Mediated Palmitoylation of ORF3a Promotes SARS-CoV-2 Pathogenesis by Antagonizing TRIM16-Mediated Ubiquitination and Proteasomal Degradation.,2026,10.1002/advs.75591,https://pubmed.ncbi.nlm.nih.gov/42107085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,42086121,Activation of tripartite motif-containing protein 16 improves cardiac function in aging mice by regulating Mfn2-dependent mitochondrial fusion through Sirt6.,2026,10.1016/j.cellsig.2026.112573,https://pubmed.ncbi.nlm.nih.gov/42086121/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,42454546,"Chromosome-scale genome of European anchovy (Engraulis encrasicolus L., 1758) and comparative genomics uncover clupeid-specific immune gene expansions.",2026,10.1093/dnares/dsag009,https://pubmed.ncbi.nlm.nih.gov/42454546/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,40491313,EBBP-Mediated Integrated Stress Response Attenuates Anthracycline-Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes.,2025,10.1002/advs.202502726,https://pubmed.ncbi.nlm.nih.gov/40491313/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,40796898,"Exosome-delivered METTL14 drives hypoxia-induced proliferation, metastasis, and glycolysis of breast cancer cells through regulating TRIM16-mediated FGF7 ubiquitination.",2025,10.1186/s13058-025-02099-2,https://pubmed.ncbi.nlm.nih.gov/40796898/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,40991993,The protective role of TRIM16 in rheumatoid arthritis: mechanisms of modulating ferroptosis.,2025,10.1016/j.intimp.2025.115573,https://pubmed.ncbi.nlm.nih.gov/40991993/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,42594767,Ebselen inhibits PRRSV replication by activating the TRIM16/SQSTM1-KEAP1-NRF2-mediated oxidative stress response pathway.,2026,10.1016/j.vetmic.2026.111192,https://pubmed.ncbi.nlm.nih.gov/42594767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,40575853,TRIM16 Mediates K63-Linked Ubiquitination of DAB2 to Facilitate Vascular Calcification.,2025,10.1161/circresaha.125.326520,https://pubmed.ncbi.nlm.nih.gov/40575853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,40383937,TRIM16 mediates secretory autophagy in head and neck cancer-associated fibroblasts.,2025,10.1080/15548627.2025.2508064,https://pubmed.ncbi.nlm.nih.gov/40383937/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,39192479,TRIM16 facilitates SIRT-1-dependent regulation of antioxidant response to alleviate age-related sarcopenia.,2024,10.1002/jcsm.13553,https://pubmed.ncbi.nlm.nih.gov/39192479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,41225541,TGF-β2 increases eHSP90α secretion via upregulating secretory autophagy pathway.,2025,10.1186/s12964-025-02493-5,https://pubmed.ncbi.nlm.nih.gov/41225541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,39367988,NPRL2 promotes TRIM16-mediated ubiquitination degradation of Galectin-3 to prevent CD8+T lymphocyte cuproptosis in glioma.,2024,10.1007/s00018-024-05454-2,https://pubmed.ncbi.nlm.nih.gov/39367988/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,42092406,TRIM16 attenuates TDP43-mediated oxidative injury by coordinating Nrf2 activation and TFR1 autophagic degradation.,2026,10.1016/j.freeradbiomed.2026.05.014,https://pubmed.ncbi.nlm.nih.gov/42092406/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,37977258,ZnO nanoparticles impair autophagic flux and cell viability through the TRIM16-NRF2-p62 pathway in inflammatory keratinocytes.,2023,10.1016/j.fct.2023.114177,https://pubmed.ncbi.nlm.nih.gov/37977258/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,38488668,TFEB ameliorates DEHP-induced neurotoxicity by activating GAL3/TRIM16 axis dependent lysophagy and alleviating lysosomal dysfunction.,2024,10.1002/tox.24221,https://pubmed.ncbi.nlm.nih.gov/38488668/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,37477507,TRIM16 E121D variant affects the risk and prognosis of hepatocellular carcinoma by modulating the Wnt/β-catenin pathway.,2023,10.1002/mc.23608,https://pubmed.ncbi.nlm.nih.gov/37477507/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,37417356,Saikosaponin A protects against uremic toxin indole‑3 acetic acid‑induced damage to the myocardium.,2023,10.3892/mmr.2023.13046,https://pubmed.ncbi.nlm.nih.gov/37417356/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,38149724,Cordyceps cicadae polysaccharides attenuate diabetic nephropathy via the miR-30a-3p/TRIM16 axis.,2024,10.1111/jdi.14116,https://pubmed.ncbi.nlm.nih.gov/38149724/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,41082270,Intracellular Mechanical Stress-Mediated Autophagy Cell Death via Nanospikes for Cancer Treatment.,2026,10.1002/advs.202512256,https://pubmed.ncbi.nlm.nih.gov/41082270/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,40608798,Bioinformatics-guided construction of a tumor microenvironment-derived prognostic model in acute myeloid leukemia.,2025,10.1371/journal.pone.0325145,https://pubmed.ncbi.nlm.nih.gov/40608798/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,39511617,Co-regulated ceRNA network mediated by circRNA and lncRNA in patients with gouty arthritis.,2024,10.1186/s12920-024-02038-8,https://pubmed.ncbi.nlm.nih.gov/39511617/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,33184347,Withaferin A activates TRIM16 for its anti-cancer activity in melanoma.,2020,10.1038/s41598-020-76722-x,https://pubmed.ncbi.nlm.nih.gov/33184347/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,38393256,Particulate Matter Induces Oxidative Stress and Ferroptosis in Human Lung Epithelial Cells.,2024,10.3390/toxics12020161,https://pubmed.ncbi.nlm.nih.gov/38393256/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,42256736,Genome-wide association study of the antibody response to &lt;i&gt;Corynebacterium pseudotuberculosis&lt;/i&gt; in sheep.,2025,10.5194/aab-68-109-2025,https://pubmed.ncbi.nlm.nih.gov/42256736/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,30806139,TRIM16 governs the biogenesis and disposal of stress-induced protein aggregates to evade cytotoxicity: implication for neurodegeneration and cancer.,2019,10.1080/15548627.2019.1586251,https://pubmed.ncbi.nlm.nih.gov/30806139/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,33681288,Identification of Tumor Mutation Burden and Immune Infiltrates in Hepatocellular Carcinoma Based on Multi-Omics Analysis.,2020,10.3389/fmolb.2020.599142,https://pubmed.ncbi.nlm.nih.gov/33681288/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM16,ENSG00000221926,Unsafe,37947597,Ferritin Is Secreted from Primary Cultured Astrocyte in Response to Iron Treatment via TRPML1-Mediated Exocytosis.,2023,10.3390/cells12212519,https://pubmed.ncbi.nlm.nih.gov/37947597/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,42567523,Fumarate hydratase suppresses glioblastoma progression by restricting fumarate-mediated succination of TRIM17.,2026,10.1016/j.jbc.2026.113401,https://pubmed.ncbi.nlm.nih.gov/42567523/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,42288623,TRIM17 downregulation modulates CRPC progression and enzalutamide resistance by derepressing BCL2 expression via the p53-dependent and p53-independent pathways.,2026,10.1038/s41418-026-01778-7,https://pubmed.ncbi.nlm.nih.gov/42288623/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,41145484,TRIM17 promotes the progression of osteosarcoma by regulating PDK1 m6A modification-mediated AKT/mTOR pathway activation through ubiquitination of FTO.,2025,10.1038/s41419-025-08070-5,https://pubmed.ncbi.nlm.nih.gov/41145484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,41871027,Discovery of novel murine PML isoforms.,2026,10.1080/19491034.2026.2646815,https://pubmed.ncbi.nlm.nih.gov/41871027/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,42292357,"TRIM47: molecular characteristics, disease-related mechanisms, and clinical translational value.",2026,10.3389/fimmu.2026.1830642,https://pubmed.ncbi.nlm.nih.gov/42292357/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,40695795,ILF3 promotes colorectal cancer cell resistance to ferroptosis by enhancing cysteine uptake and GSH synthesis via stabilizing SLC3A2 mRNA.,2025,10.1038/s41419-025-07872-x,https://pubmed.ncbi.nlm.nih.gov/40695795/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,40379611,ZSCAN21 mediates the pathogenic transcriptional induction of α-synuclein in cellular and animal models of Parkinson's disease.,2025,10.1038/s41419-025-07722-w,https://pubmed.ncbi.nlm.nih.gov/40379611/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,42555825,&lt;i&gt;Tet&lt;/i&gt; Trim-Away: a conditional rapid protein degradation system for &lt;i&gt;Tetrahymena thermophila&lt;/i&gt;.,2026,10.1091/mbc.e26-05-0233,https://pubmed.ncbi.nlm.nih.gov/42555825/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,37697039,The E3 ubiquitin ligase TRIM17 promotes gastric cancer survival and progression via controlling BAX stability and antagonizing apoptosis.,2023,10.1038/s41418-023-01221-1,https://pubmed.ncbi.nlm.nih.gov/37697039/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,39587079,Cryo-EM structure of PML RBCC dimer reveals CC-mediated octopus-like nuclear body assembly mechanism.,2024,10.1038/s41421-024-00735-3,https://pubmed.ncbi.nlm.nih.gov/39587079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,39335502,Inflammaging: Expansion of Molecular Phenotype and Role in Age-Associated Female Infertility.,2024,10.3390/biomedicines12091987,https://pubmed.ncbi.nlm.nih.gov/39335502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,36988770,Tripartite Motif Protein Family in Central Nervous System Diseases.,2023,10.1007/s10571-023-01337-5,https://pubmed.ncbi.nlm.nih.gov/36988770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,34069831,To Ubiquitinate or Not to Ubiquitinate: TRIM17 in Cell Life and Death.,2021,10.3390/cells10051235,https://pubmed.ncbi.nlm.nih.gov/34069831/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,40780616,TMEFF2 promotes hyperplastic prostate progression by degrading BAX via TRIM17.,2025,10.1016/j.cellsig.2025.112050,https://pubmed.ncbi.nlm.nih.gov/40780616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,37990144,Probable human origin of the SARS-CoV-2 polybasic furin cleavage motif.,2023,10.1186/s12863-023-01169-8,https://pubmed.ncbi.nlm.nih.gov/37990144/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,41669795,Building evidence for transfusion practice: A pilot study on bacterial adhesion and growth in red blood cell infusion sets.,2026,10.1111/trf.70104,https://pubmed.ncbi.nlm.nih.gov/41669795/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,41504013,Targeting the TRIM28-EZH2 Protein-Protein Interface With Cysteine-Reactive Covalent Inhibitors: A Computational Blueprint for Cancer Therapy.,2026,10.1002/cbdv.202502892,https://pubmed.ncbi.nlm.nih.gov/41504013/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,35220278,Telomere length in leucocytes and solid tissues of young and aged rats.,2022,10.18632/aging.203922,https://pubmed.ncbi.nlm.nih.gov/35220278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,37219768,TRIM17-mediated ubiquitination and degradation of RBM38 promotes cisplatin resistance in non-small cell lung cancer.,2023,10.1007/s13402-023-00825-6,https://pubmed.ncbi.nlm.nih.gov/37219768/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,41953019,CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response.,2026,10.3389/fimmu.2026.1744833,https://pubmed.ncbi.nlm.nih.gov/41953019/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,39909472,Red blood cell casts on kidney biopsy and progression of IgA nephropathy.,2025,10.1093/ndt/gfaf023,https://pubmed.ncbi.nlm.nih.gov/39909472/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,41672712,Bacterial proliferation is comparable in red blood cell concentrates stored in DEHT/PAGGSM and DEHP/SAGM containers.,2026,10.1111/vox.70195,https://pubmed.ncbi.nlm.nih.gov/41672712/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,40083393,Herpes Zoster Infections With Multiple Sclerosis Disease-Modifying Therapies: A Real-World Pharmacovigilance Study.,2025,10.1212/cpj.0000000000200462,https://pubmed.ncbi.nlm.nih.gov/40083393/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,40421416,Insights into the protein domains of C-VI TRIM subfamily in viral infection.,2025,10.3389/fcimb.2025.1573422,https://pubmed.ncbi.nlm.nih.gov/40421416/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,37367937,Comprehensive analysis of the prognostic and immunological signature of eight Tripartitemotif (TRIM) family molecules in human gliomas.,2023,10.18632/aging.204841,https://pubmed.ncbi.nlm.nih.gov/37367937/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,38372920,"Forest waste composting-operational management, environmental impacts, and application.",2025,10.1007/s11356-024-32279-0,https://pubmed.ncbi.nlm.nih.gov/38372920/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,37124610,Blood cell traits and risk of glaucoma: A two-sample mendelian randomization study.,2023,10.3389/fgene.2023.1142773,https://pubmed.ncbi.nlm.nih.gov/37124610/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,39725733,E3 ubiquitin ligase TRIM2 identified as a novel suppressor of CYP11B2 and aldosterone production.,2024,10.1007/s00018-024-05545-0,https://pubmed.ncbi.nlm.nih.gov/39725733/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM17,ENSG00000162931,Unsafe,19358823,"TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase.",2009,10.1016/j.bbrc.2009.04.010,https://pubmed.ncbi.nlm.nih.gov/19358823/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,42892647,TRIM36 catalyzes K63-linked ubiquitination of TAK1 to drive septic inflammation.,2026,10.1007/s00011-026-02393-5,https://pubmed.ncbi.nlm.nih.gov/42892647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,41323265,TRIM36 inhibits lung fibroblast activation and pulmonary fibrosis through the degradation of phospho-AKT1.,2025,10.1016/j.isci.2025.113775,https://pubmed.ncbi.nlm.nih.gov/41323265/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,41553545,E3 ubiquitin ligase trim36 targets ddx3x for degradation to reprogram macrophage polarization and ameliorate tubal factor infertility in rats.,2026,10.1007/s10565-026-10140-z,https://pubmed.ncbi.nlm.nih.gov/41553545/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,41940332,&lt;i&gt;TRIM36&lt;/i&gt; and &lt;i&gt;CAMK2N2&lt;/i&gt; regulate ferroptosis and antigen presentation in small cell lung cancer.,2026,10.1016/j.isci.2026.115310,https://pubmed.ncbi.nlm.nih.gov/41940332/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,41960164,Low-level lasers can improve spermatogenesis in infertile mice by targeting molecular pathways.,2026,10.34172/bi.31018,https://pubmed.ncbi.nlm.nih.gov/41960164/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,40028597,TRIM36 serves as a prognostic indicator linked to immune infiltration in KIRC.,2025,10.1016/j.heliyon.2025.e42540,https://pubmed.ncbi.nlm.nih.gov/40028597/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,39803720,TRIM36 Inhibits the Development of AOM/DSS-Induced Colitis-Associated Colorectal Cancer by Promoting the Ubiquitination and Degradation of GRB7.,2025,10.1002/mc.23871,https://pubmed.ncbi.nlm.nih.gov/39803720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,40723250,The Roles of Tripartite Motif Proteins in Urological Cancers: A Systematic Review.,2025,10.3390/cancers17142367,https://pubmed.ncbi.nlm.nih.gov/40723250/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,35053362,Microtubular TRIM36 E3 Ubiquitin Ligase in Embryonic Development and Spermatogenesis.,2022,10.3390/cells11020246,https://pubmed.ncbi.nlm.nih.gov/35053362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,42508108,Autophagy-related responses in Pacific oyster Crassostrea gigas exposed to phenanthrene: Association with a putative E3 ubiquitin ligase-NF-κB regulatory axis.,2026,10.1016/j.ecoenv.2026.120574,https://pubmed.ncbi.nlm.nih.gov/42508108/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,36799474,Trigred motif 36 regulates neuroendocrine differentiation of prostate cancer via HK2 ubiquitination and GPx4 deficiency.,2023,10.1111/cas.15763,https://pubmed.ncbi.nlm.nih.gov/36799474/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,40821731,Structural analysis of TRIM family PRYSPRY domains and its implications for E3-ligand design.,2025,10.1016/j.yjsbx.2025.100134,https://pubmed.ncbi.nlm.nih.gov/40821731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,38697008,Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice.,2024,10.1016/j.jri.2024.104252,https://pubmed.ncbi.nlm.nih.gov/38697008/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,36068629,TRIM36 inhibits tumorigenesis through the Wnt/β-catenin pathway and promotes caspase-dependent apoptosis in hepatocellular carcinoma.,2022,10.1186/s12935-022-02692-x,https://pubmed.ncbi.nlm.nih.gov/36068629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,41008661,&lt;i&gt;NUAK2&lt;/i&gt; Pathogenic Variants Are Definitively Associated with Neural Tube Defects in Humans: New Genotype-Phenotype Correlation and Review of the Literature.,2025,10.3390/diagnostics15182289,https://pubmed.ncbi.nlm.nih.gov/41008661/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,39648428,Exploring the Biological Effects of Polystyrene Nanoplastics on Spermatogenesis: Insights From Transcriptomic Analysis in Mouse Spermatocytes.,2025,10.1177/10915818241305086,https://pubmed.ncbi.nlm.nih.gov/39648428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,37875418,FOXA2 Suppression by TRIM36 Exerts Anti-Tumor Role in Colorectal Cancer Via Inducing NRF2/GPX4-Regulated Ferroptosis.,2023,10.1002/advs.202304521,https://pubmed.ncbi.nlm.nih.gov/37875418/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,36062277,Extracellular Polysaccharide from Rhizopus nigricans Inhibits Hepatocellular Carcinoma via miR-494-3p/TRIM36 Axis and Cyclin E Ubiquitination.,2022,10.14218/jcth.2021.00301,https://pubmed.ncbi.nlm.nih.gov/36062277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,40341176,OTX2 expression contributes progression of gastric cancer in young adults.,2025,10.1038/s41598-025-99632-2,https://pubmed.ncbi.nlm.nih.gov/40341176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,36035305,Exploring Early Physical Examination Diagnostic Biomarkers for Alzheimer's Disease Based on Least Absolute Shrinkage and Selection Operator.,2022,10.1155/2022/3039248,https://pubmed.ncbi.nlm.nih.gov/36035305/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,36588538,Identification of an Immune-Related Gene Signature Associated with Prognosis and Tumor Microenvironment in Esophageal Cancer.,2022,10.1155/2022/7413535,https://pubmed.ncbi.nlm.nih.gov/36588538/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,35231813,CpG site-specific methylation as epi-biomarkers for the prediction of health risk in PAHs-exposed populations.,2022,10.1016/j.jhazmat.2022.128538,https://pubmed.ncbi.nlm.nih.gov/35231813/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,30238687,Androgen-responsive tripartite motif 36 enhances tumor-suppressive effect by regulating apoptosis-related pathway in prostate cancer.,2018,10.1111/cas.13803,https://pubmed.ncbi.nlm.nih.gov/30238687/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,28359976,TRIM36 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation.,2017,10.1016/j.envpol.2017.03.001,https://pubmed.ncbi.nlm.nih.gov/28359976/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,32973212,Novel targets identified by integrated proteomic and phosphoproteomic analysis in spermatogenesis of swamp buffalo (Bubalus bubalis).,2020,10.1038/s41598-020-72353-4,https://pubmed.ncbi.nlm.nih.gov/32973212/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,32149111,Comprehensive Analysis of lncRNA-Mediated ceRNA Crosstalk and Identification of Prognostic Biomarkers in Wilms' Tumor.,2020,10.1155/2020/4951692,https://pubmed.ncbi.nlm.nih.gov/32149111/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,28087737,A homozygous mutation in TRIM36 causes autosomal recessive anencephaly in an Indian family.,2017,10.1093/hmg/ddx020,https://pubmed.ncbi.nlm.nih.gov/28087737/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM36,ENSG00000152503,Unsafe,15145053,Cloning and characterisation of the RBCC728/TRIM36 zinc-binding protein from the tumor suppressor gene region at chromosome 5q22.3.,2004,10.1016/j.gene.2004.02.045,https://pubmed.ncbi.nlm.nih.gov/15145053/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,41572508,TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2.,2026,10.1002/advs.202521337,https://pubmed.ncbi.nlm.nih.gov/41572508/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,40948140,Arabinoxylan and glycolysis inhibitors alleviate trimethylamine accumulation and gut barrier impairment by inhibiting the PERK pathway.,2025,10.1039/d5fo03078a,https://pubmed.ncbi.nlm.nih.gov/40948140/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,41267785,Identification of Shared Diagnostic Biomarkers LCN2 and DUOX2 for Inflammatory Bowel Disease and Cholangiocarcinoma Through Integrative Bioinformatics and Machine Learning.,2025,10.2147/jir.s558859,https://pubmed.ncbi.nlm.nih.gov/41267785/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,38901248,Targeting TRIM40 signaling reduces esophagus cancer development: A mechanism involving in protection of oroxylin A.,2024,10.1016/j.intimp.2024.112362,https://pubmed.ncbi.nlm.nih.gov/38901248/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,39357549,TRIM40 interacts with ROCK1 directly and inhibits colorectal cancer cell proliferation through the c-Myc/p21 axis.,2024,10.1016/j.bbamcr.2024.119855,https://pubmed.ncbi.nlm.nih.gov/39357549/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,39792251,Rnd3 Ameliorates Diabetic Cardiac Microvascular Injury via Facilitating Trim40-Mediated Rock1 Ubiquitination.,2025,10.2337/db24-0543,https://pubmed.ncbi.nlm.nih.gov/39792251/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,36755029,TRIM40 is a pathogenic driver of inflammatory bowel disease subverting intestinal barrier integrity.,2023,10.1038/s41467-023-36424-0,https://pubmed.ncbi.nlm.nih.gov/36755029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,37146559,TRIM40 ameliorates diabetic retinopathy through suppressing inflammation via Reelin/DAB1 signaling disruption: A mechanism by proteasomal degradation of DAB1.,2023,10.1016/j.bbrc.2023.04.020,https://pubmed.ncbi.nlm.nih.gov/37146559/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,38005825,Pteropus vampyrus TRIM40 Is an Interferon-Stimulated Gene That Antagonizes RIG-I-like Receptors.,2023,10.3390/v15112147,https://pubmed.ncbi.nlm.nih.gov/38005825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,40244264,Advancing Personalized Medicine in Alzheimer's Disease: Liquid Biopsy Epigenomics Unveil &lt;i&gt;APOE&lt;/i&gt; ε4-Linked Methylation Signatures.,2025,10.3390/ijms26073419,https://pubmed.ncbi.nlm.nih.gov/40244264/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,40564099,Integrative Analysis of Plasma Proteomics and Transcriptomics Reveals Potential Therapeutic Targets for Psoriasis.,2025,10.3390/biomedicines13061380,https://pubmed.ncbi.nlm.nih.gov/40564099/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,40542411,Clinical progression and genetic pathways in body-first and brain-first Parkinson's disease.,2025,10.1186/s13024-025-00866-5,https://pubmed.ncbi.nlm.nih.gov/40542411/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,38253527,"EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses.",2024,10.1038/s41467-024-44960-6,https://pubmed.ncbi.nlm.nih.gov/38253527/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,39653243,The host restriction factor SERINC5 inhibits HIV-1 transcription by negatively regulating NF-κB signaling.,2025,10.1016/j.jbc.2024.108058,https://pubmed.ncbi.nlm.nih.gov/39653243/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,39251458,"Molecular similarities between the genes for Trypanosoma cruzi microtubule-associated proteins, mammalian interferons, and TRIMs.",2024,10.1007/s00436-024-08329-4,https://pubmed.ncbi.nlm.nih.gov/39251458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,37686511,Whole Exome-Wide Association Identifies Rare Variants in GALNT9 Associated with Middle Eastern Papillary Thyroid Carcinoma Risk.,2023,10.3390/cancers15174235,https://pubmed.ncbi.nlm.nih.gov/37686511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,40169050,Evaluation of the efficacy of cell-penetrating monoclonal antibodies targeting intracellular p-NLRP3&lt;sup&gt;S295&lt;/sup&gt; in alleviating hepatotoxicant-induced NAFLD.,2025,10.1016/j.ijbiomac.2025.142696,https://pubmed.ncbi.nlm.nih.gov/40169050/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,37759668,Literature-Based Discovery to Elucidate the Biological Links between Resistant Hypertension and COVID-19.,2023,10.3390/biology12091269,https://pubmed.ncbi.nlm.nih.gov/37759668/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,30906467,Acetic acid alleviates the inflammatory response and liver injury in septic mice by increasing the expression of TRIM40.,2019,10.3892/etm.2019.7274,https://pubmed.ncbi.nlm.nih.gov/30906467/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,34177938,Emerging Roles of MHC Class I Region-Encoded E3 Ubiquitin Ligases in Innate Immunity.,2021,10.3389/fimmu.2021.687102,https://pubmed.ncbi.nlm.nih.gov/34177938/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,29117565,The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I.,2017,10.1016/j.celrep.2017.10.020,https://pubmed.ncbi.nlm.nih.gov/29117565/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,27258892,Association of MHC region SNPs with irritant susceptibility in healthcare workers.,2016,10.3109/1547691x.2016.1173135,https://pubmed.ncbi.nlm.nih.gov/27258892/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,21682861,Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving.,2011,10.1186/1471-2148-11-171,https://pubmed.ncbi.nlm.nih.gov/21682861/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,23190605,Overexpression of Uromodulin-like1 accelerates follicle depletion and subsequent ovarian degeneration.,2012,10.1038/cddis.2012.169,https://pubmed.ncbi.nlm.nih.gov/23190605/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM40,ENSG00000204614,Unsafe,21474709,TRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancers.,2011,10.1093/carcin/bgr068,https://pubmed.ncbi.nlm.nih.gov/21474709/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,42380918,The ubiquitin E3 ligase TRIM59 in myeloid cell regulates complement C3 through degrading CCAAT/enhancer binding protein β to promote neuron survival after ischemic stroke.,2026,10.1186/s13578-026-01605-z,https://pubmed.ncbi.nlm.nih.gov/42380918/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,42800466,TRIM59 attenuates sleep disturbances and improves hippocampal neuronal injury in PCPA-induced sleep-deprived male mice via the NLRP3 signaling pathway.,2026,10.1016/j.npep.2026.102663,https://pubmed.ncbi.nlm.nih.gov/42800466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,42625456,TRIM59 Drives Bladder Cancer Progression Through E3 Ligase-Dependent K48-Linked Degradation of PTRF.,2026,10.1111/cas.70510,https://pubmed.ncbi.nlm.nih.gov/42625456/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,41413601,Targeting TRIM59 impairs RNA splicing and promotes neuroblastoma differentiation and therapeutic responses.,2025,10.1186/s13046-025-03573-7,https://pubmed.ncbi.nlm.nih.gov/41413601/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,41971643,TRIM59 alleviates neuronal ferroptosis and promotes functional recovery after spinal cord injury by mediating ubiquitination and degradation of ANXA2.,2026,10.1016/j.jot.2026.101070,https://pubmed.ncbi.nlm.nih.gov/41971643/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,41710851,"TRIM59 (Tripartite Motif-Containing 59) Expression in Pan-Cancer and Its Diagnostic and Prognostic Implications in Breast Cancer, Esophageal Cancer, Lung Squamous Cell Carcinoma, and Stomach Adenocarcinoma.",2026,10.7759/cureus.101752,https://pubmed.ncbi.nlm.nih.gov/41710851/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,41705369,Phosphatidic Acid-TRIM59-Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI.,2026,10.1002/advs.202521296,https://pubmed.ncbi.nlm.nih.gov/41705369/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,41791705,PLLP inhibits the progression of WT p53 gastric cancer by reducing p53 protein ubiquitination by binding to TRIM59.,2026,10.1016/j.jbc.2026.111341,https://pubmed.ncbi.nlm.nih.gov/41791705/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,42245669,TRIM59 promotes immune evasion and tumor progression in lung adenocarcinoma via ubiquitin- proteasomal degradation of IRF3.,2026,10.3389/fimmu.2026.1813280,https://pubmed.ncbi.nlm.nih.gov/42245669/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,41372105,Eugenol as a game-changer: overcoming osimertinib resistance in non-small cell lung cancer by inhibiting glycolysis via the tripartite motif containing 59/extracellular signal-regulated kinase pathway.,2026,10.1097/cad.0000000000001793,https://pubmed.ncbi.nlm.nih.gov/41372105/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,41982165,Ubiquitin-dependent degradation of MBD3 by TRIM59 promotes lung adenocarcinoma.,2026,10.3724/abbs.2026044,https://pubmed.ncbi.nlm.nih.gov/41982165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,40790033,TRIM59 suppresses mitochondrial-associated apoptosis to facilitate progression in papillary renal cell carcinoma via the ACAT1-cardiolipin pathway.,2025,10.1038/s41419-025-07913-5,https://pubmed.ncbi.nlm.nih.gov/40790033/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,40588013,"TRIM59 deficiency aggravates HFD-induced obesity in mice associated with increased adipose tissue inflammation, lipid accumulation, and apoptosis.",2025,10.1016/j.cellsig.2025.111954,https://pubmed.ncbi.nlm.nih.gov/40588013/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,39051047,Myeloid Cell Trim59 Deficiency Worsens Experimental Ischemic Stroke and Alters Cerebral Proteomic Profile.,2024,10.2147/jir.s469651,https://pubmed.ncbi.nlm.nih.gov/39051047/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,40723250,The Roles of Tripartite Motif Proteins in Urological Cancers: A Systematic Review.,2025,10.3390/cancers17142367,https://pubmed.ncbi.nlm.nih.gov/40723250/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,40795049,TRIM59 regulates autophagy-dependent ferroptosis in non-small cell lung cancer by modulating the ubiquitination of TMEM164.,2025,10.1093/bbb/zbaf118,https://pubmed.ncbi.nlm.nih.gov/40795049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,41942785,Integrative multimodal transcriptomics identifies a cancer-associated fibroblast membrane signature for predicting prognosis and therapeutic response in pancreatic ductal adenocarcinoma.,2026,10.1007/s00109-026-02669-7,https://pubmed.ncbi.nlm.nih.gov/41942785/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,39263074,TRIM59 is required for mouse GC-1 cell maintenance through modulating the ubiquitination of AXIN1.,2024,10.1016/j.heliyon.2024.e36744,https://pubmed.ncbi.nlm.nih.gov/39263074/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,38291200,TRIM59 suppresses the brain ischaemia/reperfusion injury and pyroptosis of microglial through mediating the ubiquitination of NLRP3.,2024,10.1038/s41598-024-52914-7,https://pubmed.ncbi.nlm.nih.gov/38291200/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,42471918,DNA Methylation at Core N-Methyl-D-Aspartate (NMDA) Receptor Genes Reveals a Glutamatergic Signature of Aging in Post-COVID Whole Blood With Implications for Long-COVID Neuropsychiatric Sequelae.,2026,10.7759/cureus.112902,https://pubmed.ncbi.nlm.nih.gov/42471918/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,41074451,Identification of &lt;i&gt;TRIM59&lt;/i&gt; as a Key Biomarker for Ferroptosis Resistance and Immunotherapy Response in Bladder Cancer via Multi-Omics Integration and Machine Learning.,2025,10.31083/fbl44395,https://pubmed.ncbi.nlm.nih.gov/41074451/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,41289662,"A hexaplex droplet digital PCR assay for DNA methylation-based age prediction from blood samples targeting ELOVL2, FHL2, and TRIM59.",2026,10.1016/j.fsigen.2025.103396,https://pubmed.ncbi.nlm.nih.gov/41289662/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,39451518,"TRIM25, TRIM28 and TRIM59 and Their Protein Partners in Cancer Signaling Crosstalk: Potential Novel Therapeutic Targets for Cancer.",2024,10.3390/cimb46100638,https://pubmed.ncbi.nlm.nih.gov/39451518/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,36417114,TRIM59 promotes steatosis and ferroptosis in non-alcoholic fatty liver disease via enhancing GPX4 ubiquitination.,2023,10.1007/s13577-022-00820-3,https://pubmed.ncbi.nlm.nih.gov/36417114/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,38275209,Epigenetic age prediction using costal cartilage for the investigation of disaster victims and missing persons.,2024,10.1111/1556-4029.15470,https://pubmed.ncbi.nlm.nih.gov/38275209/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,40775408,Integrative analysis identifies FBXO5 as a critical mediator of CRPC progression and bone metastatic potential.,2025,10.1007/s12672-025-03069-y,https://pubmed.ncbi.nlm.nih.gov/40775408/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIM59,ENSG00000213186,Unsafe,34397900,Potential value of tripartite motif-containing 59 as a biomarker for predicting the prognosis of patients with lung cancer: A protocol for systematic review and meta-analysis.,2021,10.1097/md.0000000000026868,https://pubmed.ncbi.nlm.nih.gov/34397900/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,40702521,A homozygous TRIP13 pathogenic variant associated with familiar oocyte arrest and prematurely condensed sperm chromosomes.,2025,10.1186/s13039-025-00722-7,https://pubmed.ncbi.nlm.nih.gov/40702521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,42099656,Multi-omics analysis and functional validation reveal the oncogenic role of TRIP13.,2026,10.3389/fimmu.2026.1691436,https://pubmed.ncbi.nlm.nih.gov/42099656/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,42288680,Targeting mitochondrial TRIP13-AIF interaction suppresses myeloid leukemia progression and overcomes drug resistance.,2026,10.1038/s41388-026-03852-3,https://pubmed.ncbi.nlm.nih.gov/42288680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,39207914,TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis.,2024,10.7554/elife.92195,https://pubmed.ncbi.nlm.nih.gov/39207914/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,42000600,AAA ATPase TRIP13 is overexpressed in prostate cancer and promotes tumor progression.,2026,10.1016/j.tranon.2026.102743,https://pubmed.ncbi.nlm.nih.gov/42000600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,41907269,TRIP13 identified by WGCNA as a progression-related and prognostic biomarker in ovarian cancer.,2026,10.3389/fmed.2026.1765576,https://pubmed.ncbi.nlm.nih.gov/41907269/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,42688965,"Isoform-resolved 14-3-3/YWHA networks in colorectal cancer: phospho-adaptor mechanisms, biomarker contexts and therapeutic opportunities.",2026,10.3389/fonc.2026.1906093,https://pubmed.ncbi.nlm.nih.gov/42688965/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,42915736,TRIP13 Promotes Aflatoxin B1-Induced Hepatocellular Carcinoma Progression by Inhibiting Ferroptosis.,2026,10.1021/acs.chemrestox.6c00310,https://pubmed.ncbi.nlm.nih.gov/42915736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,42464653,Triptonide enhances DNA damage by inhibiting TRIP13‑mediated DNA repair and synergizes with bortezomib to suppress multiple myeloma.,2026,10.3892/ijo.2026.5919,https://pubmed.ncbi.nlm.nih.gov/42464653/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,41353268,TRIP13 alters mitochondrial function and promotes bortezomib resistance in multiple myeloma.,2025,10.1038/s41598-025-31265-x,https://pubmed.ncbi.nlm.nih.gov/41353268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,42013305,Dual Inhibition of TRIP13 and Aurora A Induces Mitotic DNA Damage and Concurrent Pyroptotic-Apoptotic Cell Death in Rb-Deficient Cancer Cells.,2026,10.1158/1078-0432.ccr-25-4712,https://pubmed.ncbi.nlm.nih.gov/42013305/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,42336904,"Integrated bioinformatics, machine learning, and experimental validation identify a four-gene diagnostic signature for cervical cancer associated with PI3K/AKT signaling.",2026,10.1038/s41598-026-57689-7,https://pubmed.ncbi.nlm.nih.gov/42336904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,41007830,Decoding TRIP13's Role in Gastric Cancer: Implications for Prognosis and Immune Response.,2025,10.3390/biomedicines13092268,https://pubmed.ncbi.nlm.nih.gov/41007830/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,42456201,Silencing thyroid hormone receptor interactor 13/kinetochore-associated 1 inhibits DNA damage repair and enhances Olaparib sensitivity in ovarian cancer.,2026,10.1016/j.jpet.2026.104964,https://pubmed.ncbi.nlm.nih.gov/42456201/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,41535263,TRIP13 promotes the expansion and immunosuppression of CD4&lt;sup&gt;+&lt;/sup&gt;Foxp3&lt;sup&gt;+&lt;/sup&gt; regulatory T cells by sustaining HAT1 stability.,2026,10.1038/s41419-025-08214-7,https://pubmed.ncbi.nlm.nih.gov/41535263/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,41145438,"Melatonin suppresses cancer cell proliferation, DNA repair and expression of the oncogene TRIP13.",2025,10.1038/s41420-025-02788-z,https://pubmed.ncbi.nlm.nih.gov/41145438/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,41828362,Genetic Mutations and Non-Genomic Dysregulation in Human Preimplantation Embryo Arrest.,2026,10.3390/ijms27052135,https://pubmed.ncbi.nlm.nih.gov/41828362/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,41487520,Mitophagy-related gene TRIP13 predicts prognosis and immune response and promotes proliferation and migration &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; of clear cell renal cell carcinoma.,2025,10.3389/fphar.2025.1736086,https://pubmed.ncbi.nlm.nih.gov/41487520/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,40253660,Thyroid hormone receptor interacting protein 13 is associated with prognosis and immunotherapy efficacy in human cancers: a pan-cancer analysis.,2025,10.1007/s12672-025-02385-7,https://pubmed.ncbi.nlm.nih.gov/40253660/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,40441196,Pan-cancer analysis shows that TRIP13 as a potential prognostic and immunotherapeutic biomarker for multiple cancer types including LIHC and LUAD.,2025,10.1097/md.0000000000042588,https://pubmed.ncbi.nlm.nih.gov/40441196/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,42244292,Damage&lt;b&gt;-&lt;/b&gt;associated molecular pattern &lt;b&gt;scoring system and its role in prognosis and immunotherapy&lt;/b&gt; in hepatocellular carcinoma.,2026,10.11817/j.issn.1672-7347.2026.250595,https://pubmed.ncbi.nlm.nih.gov/42244292/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,39398261,TRIP13: A promising cancer immunotherapy target.,2024,10.1002/cai2.147,https://pubmed.ncbi.nlm.nih.gov/39398261/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,40337305,Discovery of novel antimyeloma agents targeting TRIP13 by molecular modeling and bioassay.,2025,10.1039/d4md01008f,https://pubmed.ncbi.nlm.nih.gov/40337305/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,39964967,TRIP13 Is a Potential Prognostic Marker and Therapeutic Target for Endometrial Cancer.,2025,10.1615/critreveukaryotgeneexpr.2025056929,https://pubmed.ncbi.nlm.nih.gov/39964967/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,42035708,Genotoxic effects of 6PPD-quinone on juvenile European seabass (Dicentrarchus labrax): Impacts on DNA replication fidelity and oxidative DNA damage.,2026,10.1016/j.aquatox.2026.107830,https://pubmed.ncbi.nlm.nih.gov/42035708/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,40790482,TRIP13-induced NUSAP1 upregulation promotes CcRCC progression through EMT and PI3K/AKT/mTOR pathway.,2025,10.1186/s12967-025-06761-3,https://pubmed.ncbi.nlm.nih.gov/40790482/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIP13,ENSG00000071539,Unsafe,40228580,Advancing the development of TRIP13 inhibitors: A high-throughput screening approach.,2025,10.1016/j.slasd.2025.100233,https://pubmed.ncbi.nlm.nih.gov/40228580/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIQK,ENSG00000205133,Unsafe,39169736,The primate-specific presence of interferon regulatory factor-5 pseudogene 1.,2024,10.1002/jmv.29879,https://pubmed.ncbi.nlm.nih.gov/39169736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIQK,ENSG00000205133,Unsafe,32277301,Genome-wide association study identifies new loci for albuminuria in the Japanese population.,2020,10.1007/s10157-020-01884-x,https://pubmed.ncbi.nlm.nih.gov/32277301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIQK,ENSG00000205133,Unsafe,29335477,Transcriptomic signatures of cellular and humoral immune responses in older adults after seasonal influenza vaccination identified by data-driven clustering.,2018,10.1038/s41598-017-17735-x,https://pubmed.ncbi.nlm.nih.gov/29335477/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRIQK,ENSG00000205133,Unsafe,18828657,"TRIQK, a novel family of small proteins localized to the endoplasmic reticulum membrane, is conserved across vertebrates.",2008,10.2108/zsj.25.706,https://pubmed.ncbi.nlm.nih.gov/18828657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,42181738,&lt;i&gt;TRMT10A&lt;/i&gt;-Related Neurodevelopmental Disorder Without Metabolic Findings.,2026,10.1155/humu/8058409,https://pubmed.ncbi.nlm.nih.gov/42181738/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,42518040,TRMT10A maintains lipid homeostasis independently of its tRNA m&lt;sup&gt;1&lt;/sup&gt;G9 methyltransferase activity.,2026,10.1007/s11427-025-3385-2,https://pubmed.ncbi.nlm.nih.gov/42518040/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,41071892,Targeting the ATM-TRMT10A-BRCA1 axis confers synthetic lethality to PARP inhibition in metastatic castration-resistant prostate cancer.,2025,10.1126/sciadv.adw7989,https://pubmed.ncbi.nlm.nih.gov/41071892/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,40140670,TRMT10A regulates tRNA-ArgCCT m&lt;sup&gt;1&lt;/sup&gt;G9 modification to generate tRNA-derived fragments influencing vasculogenic mimicry formation in glioblastoma.,2025,10.1038/s41419-025-07548-6,https://pubmed.ncbi.nlm.nih.gov/40140670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,38950903,TRMT10A dysfunction perturbs codon translation of initiator methionine and glutamine and impairs brain functions in mice.,2024,10.1093/nar/gkae520,https://pubmed.ncbi.nlm.nih.gov/38950903/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,40097295,Characterization of the nucleolar localization signal of TRMT10A and its importance for the m1G9 methylation of tRNAs in mammalian cells.,2025,10.1093/jmcb/mjaf011,https://pubmed.ncbi.nlm.nih.gov/40097295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,39440920,New Insights Into TRMT10A Syndrome: Case Report and Literature Review.,2025,10.1002/ajmg.b.33015,https://pubmed.ncbi.nlm.nih.gov/39440920/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,38155219,dTrmt10A impacts Hsp70 chaperone m&lt;sup&gt;6&lt;/sup&gt;A levels and the stress response in the Drosophila brain.,2023,10.1038/s41598-023-50272-4,https://pubmed.ncbi.nlm.nih.gov/38155219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,33448213,"TRMT10A Mutation in a Child with Diabetes, Short Stature, Microcephaly and Hypoplastic Kidneys",2022,10.4274/jcrpe.galenos.2020.2020.0265,https://pubmed.ncbi.nlm.nih.gov/33448213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,34541035,Expanding the Phenotype of TRMT10A Mutations: Case Report and a Review of the Existing Cases,2023,10.4274/jcrpe.galenos.2021.2021.0110,https://pubmed.ncbi.nlm.nih.gov/34541035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,33067246,"tRNA methyltransferase 10 homologue A (TRMT10A) mutation in a Chinese patient with diabetes, insulin resistance, intellectual deficiency and microcephaly.",2020,10.1136/bmjdrc-2020-001601,https://pubmed.ncbi.nlm.nih.gov/33067246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,30247717,Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes.,2018,10.1093/nar/gky839,https://pubmed.ncbi.nlm.nih.gov/30247717/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,24204302,tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans.,2013,10.1371/journal.pgen.1003888,https://pubmed.ncbi.nlm.nih.gov/24204302/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,32392304,Functional characterization of the human tRNA methyltransferases TRMT10A and TRMT10B.,2020,10.1093/nar/gkaa353,https://pubmed.ncbi.nlm.nih.gov/32392304/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,32213595,Coordination of mRNA and tRNA methylations by TRMT10A.,2020,10.1073/pnas.1913448117,https://pubmed.ncbi.nlm.nih.gov/32213595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,26526202,"tRNA methyltransferase homologue gene TRMT10A mutation in young adult-onset diabetes with intellectual disability, microcephaly and epilepsy.",2016,10.1111/dme.13024,https://pubmed.ncbi.nlm.nih.gov/26526202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,37949221,tRNA m1G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10.,2023,10.1016/j.jbc.2023.105443,https://pubmed.ncbi.nlm.nih.gov/37949221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,26535115,"Case Report: Compound heterozygous nonsense mutations in TRMT10A are associated with microcephaly, delayed development, and periventricular white matter hyperintensities.",2015,10.12688/f1000research.7106.1,https://pubmed.ncbi.nlm.nih.gov/26535115/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,31292261,Distinct substrate specificities of the human tRNA methyltransferases TRMT10A and TRMT10B.,2019,10.1261/rna.072090.119,https://pubmed.ncbi.nlm.nih.gov/31292261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRMT10A,ENSG00000145331,Unsafe,25053765,"TRMT10A dysfunction is associated with abnormalities in glucose homeostasis, short stature and microcephaly.",2014,10.1136/jmedgenet-2014-102282,https://pubmed.ncbi.nlm.nih.gov/25053765/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,42458520,Heterogeneity characterization and therapeutic marker discovery of endometrial carcinoma using GeoMXT™ digital spatial profiling.,2026,10.1186/s12967-026-08606-z,https://pubmed.ncbi.nlm.nih.gov/42458520/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,42441309,"Analysis of the relationship between serum LAMC2, TROAP and clinical stages and prognosis of non-muscle invasive bladder cancer.",2026,10.1515/med-2026-1481,https://pubmed.ncbi.nlm.nih.gov/42441309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,42889252,Integrative Single-Cell and Bulk Transcriptomics Identifies a Proliferative Malignant State and Supports a Functional Contribution of TROAP in Osteosarcoma.,2026,10.1155/ijog/1407947,https://pubmed.ncbi.nlm.nih.gov/42889252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,41350492,TROAP aggravates chemoresistance of colorectal cancer cells via lipogenesis by PI3K/Akt pathway and histone acetylation.,2025,10.1007/s10142-025-01787-8,https://pubmed.ncbi.nlm.nih.gov/41350492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,40252097,TROAP promotes esophageal squamous cell carcinoma progression via the PI3K/AKT pathway.,2025,10.1007/s00432-025-06200-2,https://pubmed.ncbi.nlm.nih.gov/40252097/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,42634370,Th17 Cell-Related Gene Biomarkers in Autoimmune Thyroiditis: Comprehensive Bioinformatics Analysis and In Vivo Validation.,2026,10.2174/0113862073420296251128070854,https://pubmed.ncbi.nlm.nih.gov/42634370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,40696794,FBXW5 Promotes Epithelial-Mesenchymal Transition in Lung Adenocarcinoma Through the KLF13/TROAP Signaling Pathway.,2025,10.1002/mc.70018,https://pubmed.ncbi.nlm.nih.gov/40696794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,39153983,Evaluating trophinin associated protein as a biomarker of prognosis and therapy response in renal cell carcinoma.,2024,10.1186/s12885-024-12802-9,https://pubmed.ncbi.nlm.nih.gov/39153983/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,41008819,&lt;i&gt;CDCA8&lt;/i&gt; and &lt;i&gt;TROAP&lt;/i&gt; as Prognostic Biomarkers of Postoperative Metastatic Progression in Clear Cell Renal Cell Carcinoma.,2025,10.3390/cancers17182975,https://pubmed.ncbi.nlm.nih.gov/41008819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,39501799,E2F1-induced upregulation of &lt;i&gt;TROAP&lt;/i&gt; contributes to endometrial cancer progression.,2025,10.14670/hh-18-834,https://pubmed.ncbi.nlm.nih.gov/39501799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,37731946,"Integrative analysis of TROAP with molecular features, carcinogenesis, and related immune and pharmacogenomic characteristics in soft tissue sarcoma.",2023,10.1002/mco2.369,https://pubmed.ncbi.nlm.nih.gov/37731946/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,39586843,PCBP2 stabilizes TROAP to promote the malignant progression of gastric cancer.,2025,10.1007/s00210-024-03503-y,https://pubmed.ncbi.nlm.nih.gov/39586843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,40358820,Sunitinib-resistant renal cell carcinoma cell-derived exosomes promote facilitation of tumor progression via secretion of the lncRNA SNHG16.,2025,10.1007/s13577-025-01228-5,https://pubmed.ncbi.nlm.nih.gov/40358820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,40229714,Molecular basis identification and hypnotic drug interactions for cognitive impairment related to sleep deprivation.,2025,10.1186/s12888-024-06395-7,https://pubmed.ncbi.nlm.nih.gov/40229714/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,38967825,Clinical significance of TROAP in endometrial cancer and the antiproliferative and proapoptotic effects of TROAP knockdown in endometrial cancer cells: integrated utilization of bioinformatic analysis and in vitro test verification.,2024,10.1007/s00210-024-03260-y,https://pubmed.ncbi.nlm.nih.gov/38967825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,41614789,Integrative Bioinformatics and Experimental Validation Establish CCNB1 as a Potential Biomarker for Diagnosis and Prognosis in Colorectal Cancer.,2025,10.3390/cimb47121026,https://pubmed.ncbi.nlm.nih.gov/41614789/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,36419876,"Pan-cancer analysis of trophinin-associated protein with potential implications in clinical significance, prognosis, and tumor microenvironment in human cancers.",2022,10.3389/fonc.2022.971618,https://pubmed.ncbi.nlm.nih.gov/36419876/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,41374402,Overexpression of &lt;i&gt;CDC20&lt;/i&gt; Confer a Poorer Prognosis in Bladder Cancer Identified by Gene Co-Expression Network Analysis.,2025,10.3390/diagnostics15233016,https://pubmed.ncbi.nlm.nih.gov/41374402/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,36938721,High trophinin-associated protein expression predicts good survival in acute myeloid leukemia with normal cytogenetics.,2023,10.3233/cbm-210042,https://pubmed.ncbi.nlm.nih.gov/36938721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,38971916,Investigation on the molecular mechanism of SPA interference with osteogenic differentiation of bone marrow mesenchymal stem cells.,2024,10.1038/s41598-024-66502-2,https://pubmed.ncbi.nlm.nih.gov/38971916/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,37298609,"TROAP Promotes the Proliferation, Migration, and Metastasis of Kidney Renal Clear Cell Carcinoma with the Help of STAT3.",2023,10.3390/ijms24119658,https://pubmed.ncbi.nlm.nih.gov/37298609/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,40356980,Bioinformatics analysis across pan-cancer and experimental validation in hepatocellular carcinoma revealed the oncogenic role of SF3B6.,2025,10.3389/fphar.2025.1516534,https://pubmed.ncbi.nlm.nih.gov/40356980/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,37127623,Liquid-liquid phase separation throws novel insights into treatment strategies for skin cutaneous melanoma.,2023,10.1186/s12885-023-10847-w,https://pubmed.ncbi.nlm.nih.gov/37127623/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,39324133,Single-cell RNA sequencing reveals the communications between tumor microenvironment components and tumor metastasis in osteosarcoma.,2024,10.3389/fimmu.2024.1445555,https://pubmed.ncbi.nlm.nih.gov/39324133/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,38560563,Development of a cell adhesion-based prognostic model for multiple myeloma: Insights into chemotherapy response and potential reversal of adhesion effects.,2024,10.32604/or.2023.043647,https://pubmed.ncbi.nlm.nih.gov/38560563/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,34139453,Molecular subtypes based on CNVs related gene signatures identify candidate prognostic biomarkers in lung adenocarcinoma.,2021,10.1016/j.neo.2021.05.006,https://pubmed.ncbi.nlm.nih.gov/34139453/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,30854102,The Upregulation of Trophinin-Associated Protein (TROAP) Predicts a Poor Prognosis in Hepatocellular Carcinoma.,2019,10.7150/jca.26666,https://pubmed.ncbi.nlm.nih.gov/30854102/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,31285897,Trophinin-associated protein expression is an independent prognostic biomarker in lung adenocarcinoma.,2019,10.21037/jtd.2019.04.86,https://pubmed.ncbi.nlm.nih.gov/31285897/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,36601001,CCNB1 and AURKA are critical genes for prostate cancer progression and castration-resistant prostate cancer resistant to vinblastine.,2022,10.3389/fendo.2022.1106175,https://pubmed.ncbi.nlm.nih.gov/36601001/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,37004005,Bioinformatic analysis highlights SNHG6 as a putative prognostic biomarker for kidney renal papillary cell carcinoma.,2023,10.1186/s12894-023-01218-5,https://pubmed.ncbi.nlm.nih.gov/37004005/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,33995639,Five-gene signature associating with Gleason score serve as novel biomarkers for identifying early recurring events and contributing to early diagnosis for Prostate Adenocarcinoma.,2021,10.7150/jca.52170,https://pubmed.ncbi.nlm.nih.gov/33995639/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TROAP,ENSG00000135451,Unsafe,27295129,"Investigating core genetic-and-epigenetic cell cycle networks for stemness and carcinogenic mechanisms, and cancer drug design using big database mining and genome-wide next-generation sequencing data.",2016,10.1080/15384101.2016.1198862,https://pubmed.ncbi.nlm.nih.gov/27295129/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,41942595,Upregulated TRPM1 is associated with apoptosis in Rs1 knockout mice and in ARPE19 cells through increased intracellular calcium.,2026,10.1038/s41598-026-47523-5,https://pubmed.ncbi.nlm.nih.gov/41942595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,42702620,Non-canonical pore architecture underlies constitutive gating of human retinal TRPM1.,2026,10.1038/s41467-026-76454-y,https://pubmed.ncbi.nlm.nih.gov/42702620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,41857038,Cryo-EM structure of TRPM1 reveals a non-canonical architecture with an inverted transmembrane domain.,2026,10.1038/s41467-026-70722-7,https://pubmed.ncbi.nlm.nih.gov/41857038/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,42055330,Domain-specific functions of LRIT3 in synaptic assembly and retinal signal transmission.,2026,10.1016/j.jbc.2026.113097,https://pubmed.ncbi.nlm.nih.gov/42055330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,40869148,TRP Channels in Skin Cancer: Focus on Malignant Melanoma.,2025,10.3390/ijms26167829,https://pubmed.ncbi.nlm.nih.gov/40869148/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,42467387,Electronegative ERG in association with probable TRPM1-related cancer associated retinopathy: a case report.,2026,10.1007/s10633-026-10132-8,https://pubmed.ncbi.nlm.nih.gov/42467387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,41099728,A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness.,2025,10.1085/jgp.202413749,https://pubmed.ncbi.nlm.nih.gov/41099728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,42471459,"Gene augmentation therapy successfully treats mice with complete congenital stationary night blindness (cCSNB), improving retinal function and visual acuity.",2026,10.1038/s41434-026-00633-1,https://pubmed.ncbi.nlm.nih.gov/42471459/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,42651970,Histological and Strand-Specific Transcriptomic Analyses Reveal Developmental Dynamics and Pigmentation-Associated Candidate Genes in Black and White Skin Regions of Bama Miniature Pigs.,2026,10.3390/ani16162565,https://pubmed.ncbi.nlm.nih.gov/42651970/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,41371955,The Retinal Light Response Is Modulated by an mGluR5-Mediated Retrograde Signal from ON-Bipolar Cells to Photoreceptors.,2026,10.1523/jneurosci.2277-24.2025,https://pubmed.ncbi.nlm.nih.gov/41371955/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,41968578,Evolution in metazoans of the TRPM channel family involves multiple gains and losses of genes and domains.,2026,10.1093/molbev/msag098,https://pubmed.ncbi.nlm.nih.gov/41968578/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,40882735,New insights into sex determination in amphibians: Unraveling the regulatory roles of Trpm1 and Dmrt1 in the Chinese giant salamander (Andrias davidianus).,2025,10.1016/j.ijbiomac.2025.147194,https://pubmed.ncbi.nlm.nih.gov/40882735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,41490227,ANTI-VEGF THERAPY SWITCHING RETINAL DISEASES: Characterizing Clinical Manifestations and Common Involved Genes.,2026,10.1097/iae.0000000000004768,https://pubmed.ncbi.nlm.nih.gov/41490227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,39318594,Case report: Longitudinal evaluation and treatment of a melanoma-associated retinopathy patient.,2024,10.3389/fmed.2024.1445180,https://pubmed.ncbi.nlm.nih.gov/39318594/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,41275129,Effect of induced molting on bone remodeling in laying hens.,2025,10.1186/s12864-025-12335-w,https://pubmed.ncbi.nlm.nih.gov/41275129/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,42211199,Genotype-phenotype correlations in Chinese patients with congenital stationary night blindness and early-onset high myopia: evidence from electrophysiology and whole-exome sequencing.,2026,10.18240/ijo.2026.06.18,https://pubmed.ncbi.nlm.nih.gov/42211199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,42074509,"Mutation Screening of &lt;i&gt;ARR3&lt;/i&gt;, &lt;i&gt;CACNA1F&lt;/i&gt;, &lt;i&gt;P4HA2&lt;/i&gt;, &lt;i&gt;TRPM1&lt;/i&gt;, &lt;i&gt;COL2A1&lt;/i&gt;, &lt;i&gt;COL11A1&lt;/i&gt; and &lt;i&gt;PAX6&lt;/i&gt; in a Chinese Cohort of 37 Patients with Early-Onset High Myopia.",2026,10.3390/genes17040391,https://pubmed.ncbi.nlm.nih.gov/42074509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,41333194,ATAS-EMIT Activates the 5-HT/AC/cAMP Pathway to Ameliorate Insomnia in PCPA Insomniac Rats.,2025,10.2147/nss.s536579,https://pubmed.ncbi.nlm.nih.gov/41333194/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,42278384,Genetic and Clinical Heterogeneity of Polish Patients with Congenital Stationary Night Blindness (CSNB).,2026,10.3390/ijms27114855,https://pubmed.ncbi.nlm.nih.gov/42278384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,40930976,Trans-synaptic Interaction with mGluR6 Contributes to ELFN1 Presynaptic Enrichment in Rod Photoreceptors.,2025,10.1523/jneurosci.0785-25.2025,https://pubmed.ncbi.nlm.nih.gov/40930976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,39109318,&lt;i&gt;Anti&lt;/i&gt;-TRPM1 autoantibody-positive unilateral melanoma associated retinopathy (MAR) triggered by immunotherapy recapitulates functional and structural details of &lt;i&gt;TRPM1&lt;/i&gt;-associated congenital stationary night blindness.,2024,10.1016/j.ajoc.2024.102098,https://pubmed.ncbi.nlm.nih.gov/39109318/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,37359558,Self-delivery of TIGIT-blocking scFv enhances CAR-T immunotherapy in solid tumors.,2023,10.3389/fimmu.2023.1175920,https://pubmed.ncbi.nlm.nih.gov/37359558/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,37296886,"PDAC, the Influencer Cancer: Cross-Talk with Tumor Microenvironment and Connected Potential Therapy Strategies.",2023,10.3390/cancers15112923,https://pubmed.ncbi.nlm.nih.gov/37296886/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,39079892,Characterising the refractive error in paediatric patients with congenital stationary night blindness: a multicentre study.,2025,10.1136/bjo-2023-323747,https://pubmed.ncbi.nlm.nih.gov/39079892/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,41042798,Towards a transcriptomic biomarker for the classification of melanocytic neoplasms.,2025,10.1371/journal.pgen.1011869,https://pubmed.ncbi.nlm.nih.gov/41042798/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,40795418,Multi-omics profiling of hepatic macromolecules in laying hens with difference feed intake: Mechanistic insights into antioxidant capacity modulation.,2025,10.1016/j.psj.2025.105575,https://pubmed.ncbi.nlm.nih.gov/40795418/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,37668527,A Cell Surface-Binding Antibody Atlas Nominates a MUC18-Directed Antibody-Drug Conjugate for Targeting Melanoma.,2023,10.1158/0008-5472.can-23-1356,https://pubmed.ncbi.nlm.nih.gov/37668527/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,42106701,Electronegative electroretinography in inherited retinal disease: a systematic review of genotype-phenotype correlations.,2026,10.1186/s12886-026-04858-x,https://pubmed.ncbi.nlm.nih.gov/42106701/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,34301262,AUY922 induces retinal toxicity through attenuating TRPM1.,2021,10.1186/s12929-021-00751-5,https://pubmed.ncbi.nlm.nih.gov/34301262/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,31117125,TRPM1 Autoantibodies in Melanoma Patients Without Self-Reported Visual Symptoms.,2019,10.1167/iovs.19-26775,https://pubmed.ncbi.nlm.nih.gov/31117125/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,33785025,"Mice with mutations in Trpm1, a gene in the locus of 15q13.3 microdeletion syndrome, display pronounced hyperactivity and decreased anxiety-like behavior.",2021,10.1186/s13041-021-00749-y,https://pubmed.ncbi.nlm.nih.gov/33785025/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,38680092,Roles of TRPM channels in glioma.,2024,10.1080/15384047.2024.2338955,https://pubmed.ncbi.nlm.nih.gov/38680092/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,37220680,Extended functional rescue following AAV gene therapy in a canine model of LRIT3-congenital stationary night blindness.,2023,10.1016/j.visres.2023.108260,https://pubmed.ncbi.nlm.nih.gov/37220680/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,38522615,"Congenital Stationary Night Blindness: Structure, Function and Genotype-Phenotype Correlations in a Cohort of 122 Patients.",2024,10.1016/j.oret.2024.03.017,https://pubmed.ncbi.nlm.nih.gov/38522615/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,37970507,A genome-wide association study for the fatty acid composition of breast meat in an F2 crossbred chicken population.,2023,10.5187/jast.2023.e1,https://pubmed.ncbi.nlm.nih.gov/37970507/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,35433692,Glucocorticoid Exposure of Preimplantation Embryos Increases Offspring Anxiety-Like Behavior by Upregulating miR-211-5p via Trpm1 Demethylation.,2022,10.3389/fcell.2022.874374,https://pubmed.ncbi.nlm.nih.gov/35433692/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,30027108,A Large Endoplasmic Reticulum-Resident Pool of TRPM1 in Retinal ON-Bipolar Cells.,2018,10.1523/eneuro.0143-18.2018,https://pubmed.ncbi.nlm.nih.gov/30027108/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,19896109,Mutations in TRPM1 are a common cause of complete congenital stationary night blindness.,2009,10.1016/j.ajhg.2009.10.012,https://pubmed.ncbi.nlm.nih.gov/19896109/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,11112417,"Expression and Up-regulation of alternatively spliced transcripts of melastatin, a melanoma metastasis-related gene, in human melanoma cells.",2000,10.1006/bbrc.2000.3894,https://pubmed.ncbi.nlm.nih.gov/11112417/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM1,ENSG00000134160,Unsafe,9537257,Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis.,1998,,https://pubmed.ncbi.nlm.nih.gov/9537257/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,42764190,TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala.,2026,10.1111/bph.70669,https://pubmed.ncbi.nlm.nih.gov/42764190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,42484498,Altered TRPM3-Dependent Cytosolic and Mitochondrial Calcium Influx in Natural Killer Cells of Post-COVID-19 Condition Patients.,2026,10.1002/eji.70240,https://pubmed.ncbi.nlm.nih.gov/42484498/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,41710303,ATP release mediated by TRPM3 enhances invasion in glioblastoma.,2026,10.1080/19768354.2026.2629066,https://pubmed.ncbi.nlm.nih.gov/41710303/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,41530372,A duo of redox-sensitive pore-loop cysteines controls the activity of the neural ion channel TRPM3.,2026,10.1038/s42004-026-01889-9,https://pubmed.ncbi.nlm.nih.gov/41530372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,41922314,Stereoselectivity and functional plasticity of a common ligand-binding pocket in TRPM3.,2026,10.1038/s41467-026-71226-0,https://pubmed.ncbi.nlm.nih.gov/41922314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,42177403,Deficient TRPM3-linked mitochondrial Ca&lt;sup&gt;2+&lt;/sup&gt; influx in natural killer cells associated with myalgic encephalomyelitis/chronic fatigue syndrome.,2026,10.1186/s12865-026-00849-1,https://pubmed.ncbi.nlm.nih.gov/42177403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,41806836,TRPM3 mediates spontaneous pain and mechanical allodynia in a mouse model of chronic orofacial neuropathy.,2026,10.1016/j.xcrm.2026.102645,https://pubmed.ncbi.nlm.nih.gov/41806836/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,41133435,TRPM3 activation causes CGRP release in trigeminal neurons: Implications for migraine mechanisms.,2026,10.1111/head.15082,https://pubmed.ncbi.nlm.nih.gov/41133435/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,42612766,Memantine modulates TRPM3-associated glutamatergic signaling via vGLUT2 in a mouse model of obsessive-compulsive disorder.,2026,10.1016/j.ejphar.2026.179238,https://pubmed.ncbi.nlm.nih.gov/42612766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,42822062,Transient receptor potential melastatin 3-dependent disruption of hypothalamic paraventricular nucleus-medial prefrontal cortex serotonergic signaling promotes depressive-like behavior in ovariectomized rats.,2026,10.1016/j.jpet.2026.104991,https://pubmed.ncbi.nlm.nih.gov/42822062/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,42643274,The role of non-coding RNAs in the pathogenesis of migraine: from molecular insights to potential biomarkers.,2026,10.3389/fneur.2026.1838515,https://pubmed.ncbi.nlm.nih.gov/42643274/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,41585253,Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.,2025,10.3389/fmed.2025.1703924,https://pubmed.ncbi.nlm.nih.gov/41585253/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,41154581,"The ExPAND Study: A Prospective Association Study into Endometriosis-Associated Pain, Neurosteroid Synthesis, and TRPM3.",2025,10.3390/biom15101352,https://pubmed.ncbi.nlm.nih.gov/41154581/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,39994546,Sex difference in TRPM3 channel functioning in nociceptive and vascular systems: an emerging target for migraine therapy in females?,2025,10.1186/s10194-025-01966-9,https://pubmed.ncbi.nlm.nih.gov/39994546/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,38970055,Potential pathophysiological role of the ion channel TRPM3 in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the therapeutic effect of low-dose naltrexone.,2024,10.1186/s12967-024-05412-3,https://pubmed.ncbi.nlm.nih.gov/38970055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,41031400,Renal TRPM3 Channels Regulate Blood Pressure via Tubuloglomerular Feedback and Plasma Volume Control.,2025,10.1161/hypertensionaha.125.25790,https://pubmed.ncbi.nlm.nih.gov/41031400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,41455679,The therapeutic pipeline in migraine: What does the future hold?,2026,10.1016/j.neurot.2025.e00826,https://pubmed.ncbi.nlm.nih.gov/41455679/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,41096659,The Role of TRP Channels in Colitis and Inflammatory Bowel Disease: A Systematic Review.,2025,10.3390/ijms26199390,https://pubmed.ncbi.nlm.nih.gov/41096659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,42134321,Cilia beating of ependymal cells regulates adult neural stem cell quiescence via mechanical forces mediated by PKD1/2-TRPM3.,2026,10.1016/j.neuron.2026.04.031,https://pubmed.ncbi.nlm.nih.gov/42134321/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,39749750,Phenotype Spectrum of TRPM3-Associated Disorders.,2025,10.1002/ana.27141,https://pubmed.ncbi.nlm.nih.gov/39749750/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,40806522,Muscarinic Receptor Antagonism and TRPM3 Activation as Stimulators of Mitochondrial Function and Axonal Repair in Diabetic Sensorimotor Polyneuropathy.,2025,10.3390/ijms26157393,https://pubmed.ncbi.nlm.nih.gov/40806522/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,40458265,Low-Dose naltrexone restored TRPM3 ion channel function in natural killer cells from long COVID patients.,2025,10.3389/fmolb.2025.1582967,https://pubmed.ncbi.nlm.nih.gov/40458265/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,42650333,Developmental and/or Epileptic Encephalopathy with Spike-Wave Activation in Sleep: From Thalamocortical Mechanisms to Precision Therapy.,2026,10.3390/children13080993,https://pubmed.ncbi.nlm.nih.gov/42650333/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,39922884,Targeting TRPM3 as a potential therapeutic approach for autosomal dominant polycystic kidney disease.,2025,10.1038/s41598-025-89200-z,https://pubmed.ncbi.nlm.nih.gov/39922884/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,41990141,Thermotactic Decision-Making in Aquatic Invertebrates: High-Resolution Behavioral Analysis of Ecotoxicological Effects.,2026,10.1021/acs.est.5c16058,https://pubmed.ncbi.nlm.nih.gov/41990141/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,39621240,Diverse RNA methylation patterns in neutrophils: key drivers in hepatocellular carcinoma.,2025,10.1007/s12094-024-03756-2,https://pubmed.ncbi.nlm.nih.gov/39621240/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,39231217,Human heat sensation: A randomized crossover trial.,2024,10.1126/sciadv.ado3498,https://pubmed.ncbi.nlm.nih.gov/39231217/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,38917121,Novel characterization of endogenous transient receptor potential melastatin 3 ion channels from Gulf War Illness participants.,2024,10.1371/journal.pone.0305704,https://pubmed.ncbi.nlm.nih.gov/38917121/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,38765011,Investigation into the restoration of TRPM3 ion channel activity in post-COVID-19 condition: a potential pharmacotherapeutic target.,2024,10.3389/fimmu.2024.1264702,https://pubmed.ncbi.nlm.nih.gov/38765011/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,42047579,Developmental and/or epileptic encephalopathy with spike-and-wave activation in sleep: Pathophysiological insights and treatment options.,2026,10.1002/epi.70271,https://pubmed.ncbi.nlm.nih.gov/42047579/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,38731855,Anti-Nociceptive Effects of Sphingomyelinase and Methyl-Beta-Cyclodextrin in the Icilin-Induced Mouse Pain Model.,2024,10.3390/ijms25094637,https://pubmed.ncbi.nlm.nih.gov/38731855/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,40535770,Genetic polymorphisms as predictors of the response of hepatocellular carcinoma patients to doxorubicin chemotherapy: a genome-wide association study.,2025,10.3389/fphar.2025.1604473,https://pubmed.ncbi.nlm.nih.gov/40535770/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,25090642,"Mutation of the melastatin-related cation channel, TRPM3, underlies inherited cataract and glaucoma.",2014,10.1371/journal.pone.0104000,https://pubmed.ncbi.nlm.nih.gov/25090642/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,12672799,Molecular and functional characterization of the melastatin-related cation channel TRPM3.,2003,10.1074/jbc.m300945200,https://pubmed.ncbi.nlm.nih.gov/12672799/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPM3,ENSG00000083067,Unsafe,12672827,Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3).,2003,10.1074/jbc.m211232200,https://pubmed.ncbi.nlm.nih.gov/12672827/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42902773,Potential roles for transient receptor potential vanilloid 1 in heart failure with preserved ejection fraction.,2026,10.1080/19336950.2026.2746860,https://pubmed.ncbi.nlm.nih.gov/42902773/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42902421,Capsaicin suppresses microglial inflammation through TRPV1-SSR4 interaction.,2026,10.1186/s40035-026-00589-7,https://pubmed.ncbi.nlm.nih.gov/42902421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42766002,Identification of a human mitochondrial isoform of TRPV1: a thermostat regulating mitochondrial maximal temperature?,2026,10.1007/s00018-026-06360-5,https://pubmed.ncbi.nlm.nih.gov/42766002/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42560767,Effects of burosumab on macrophage polarization and TRPV1 expression in children with XLH.,2026,10.1530/ec-26-0183,https://pubmed.ncbi.nlm.nih.gov/42560767/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42909024,Neuroimmune activation of the TRPV1-RAMP1 axis drives type 2 immunity to repair intestinal barrier and alleviate metabolic disease.,2026,10.3389/fimmu.2026.1965520,https://pubmed.ncbi.nlm.nih.gov/42909024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42742208,TRPV1-STAT3 signaling as a driver of lethal pathology during pneumococcal nose-to-brain invasion.,2026,10.1128/spectrum.01320-26,https://pubmed.ncbi.nlm.nih.gov/42742208/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42820868,Reproductive phenotypes and transcriptomic responses associated with Trpv1 deficiency in mice.,2026,10.1093/biolre/ioag217,https://pubmed.ncbi.nlm.nih.gov/42820868/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,41893961,Bioinformatics analysis of TRPV1 expression and its role in hepatocellular carcinoma prognosis.,2026,10.1007/s12672-026-04744-4,https://pubmed.ncbi.nlm.nih.gov/41893961/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42396643,TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review).,2026,10.3892/ijmm.2026.5915,https://pubmed.ncbi.nlm.nih.gov/42396643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42281344,"Exploring the role of alpha-tocopherol in pain and inflammation: interplay with TRPV1, PKA, and PKC pathways.",2026,10.3344/kjp.25390,https://pubmed.ncbi.nlm.nih.gov/42281344/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42791932,Olopatadine Exerts Multifaceted Protective Effects in an Ovalbumin-Induced Allergic Eye Disease Mouse Model.,2026,10.3390/bioengineering13091060,https://pubmed.ncbi.nlm.nih.gov/42791932/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42524107,Molecular mechanisms of perimenopausal cognitive impairment in a rat model: multi-omics integration reveals the Adgrl2-Camk2d-TRPV1 signaling axis mediating calcium homeostasis disruption and neuroinflammation.,2026,10.3389/fnagi.2026.1862151,https://pubmed.ncbi.nlm.nih.gov/42524107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42604367,Silver Needle Thermotherapy Regulates TRPV1 to Alleviate Endoplasmic Reticulum Stress and Relieve Myofascial Pain.,2026,10.2147/jpr.s627846,https://pubmed.ncbi.nlm.nih.gov/42604367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42365227,Cannabidiol alleviates traumatic brain injury-induced neuronal damage and cognitive deficits by inhibiting ferroptosis via the TRPV1/MCU/PI3K/Akt pathway.,2026,10.1186/s11658-026-00983-z,https://pubmed.ncbi.nlm.nih.gov/42365227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42193132,Hormonal Dysregulation and Neuroinflammation in Endometriosis: Convergent Druggable Pathways.,2026,10.3390/cimb48050528,https://pubmed.ncbi.nlm.nih.gov/42193132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42761952,From Bibliometrics to Preliminary Clinical Evidence: TRP Channel-Mediated Neuroimmune Crosstalk in Temperature-Sensitive Airway Hyperresponsiveness.,2026,10.2147/jir.s611261,https://pubmed.ncbi.nlm.nih.gov/42761952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42626696,Duloxetine ameliorates acute pancreatitis-associated inflammation and modulates pain related neuroinflammatory pathways via modulation of SP-related neurokinin signaling and PAR2/TRPV1 pathways.,2026,10.3389/ftox.2026.1891784,https://pubmed.ncbi.nlm.nih.gov/42626696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42784317,α-Latrotoxin and Pain: A Nociceptor Perspective on Latrodectism.,2026,10.3390/toxins18090393,https://pubmed.ncbi.nlm.nih.gov/42784317/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42007487,Inhibition of Microglial TRPV1 Ameliorates Brain Injury After Intracerebral Hemorrhage by Suppressing AMPK/PINK1-Mediated Mitophagy.,2026,10.1002/cns.70881,https://pubmed.ncbi.nlm.nih.gov/42007487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42568828,LIPUS combined with mild hyperthermia promotes rotator cuff healing via TRPV1/Ca&lt;sup&gt;2+&lt;/sup&gt;/CaMKII-driven BACH2 nuclear translocation and inhibition of M1 polarization.,2026,10.1016/j.jot.2026.101170,https://pubmed.ncbi.nlm.nih.gov/42568828/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,41569118,"TRPV1 from the TRP family: Structure, function, implication in autoimmune diseases and potential therapies.",2026,10.1080/19336950.2026.2616902,https://pubmed.ncbi.nlm.nih.gov/41569118/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42913877,"Efficacy and safety of the TRPV1 agonist RTX-GRT7039 in patients with pain associated with knee osteoarthritis: results from a phase 3, randomised, placebo-controlled trial.",2026,10.1016/j.joca.2026.10.011,https://pubmed.ncbi.nlm.nih.gov/42913877/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42802866,A Quercetin/Rg3-Loaded Calcium Phosphate Nanoplatform Alleviates Breast Cancer-Induced Peripheral Hyperalgesia and Enhances Antitumor Immunity.,2026,10.2147/ijn.s623910,https://pubmed.ncbi.nlm.nih.gov/42802866/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42321244,Neuron-targeting piezoelectric microneedles disrupt pro-tumorigenic neuron-immune crosstalk and restore anti-tumor immunity in melanoma.,2026,10.1038/s41467-026-74550-7,https://pubmed.ncbi.nlm.nih.gov/42321244/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42500652,Immunological mechanisms and prevention strategies for febrile seizures in children.,2026,10.3389/fimmu.2026.1833132,https://pubmed.ncbi.nlm.nih.gov/42500652/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,41722000,"TRPV1 Receptor Modulators: Emerging Therapies for Neuropathic, Osteoarthritic, and Perioperative Pain.",2026,10.1007/s40263-026-01272-1,https://pubmed.ncbi.nlm.nih.gov/41722000/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42711863,Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal-Immunotherapy.,2026,10.1002/advs.77625,https://pubmed.ncbi.nlm.nih.gov/42711863/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42421687,TRPV1-mediated calcium signaling underlies the synergistic pro-apoptotic effects of lidocaine and melatonin in SH-SY5Y neuroblastoma cells.,2026,10.3389/fonc.2026.1883694,https://pubmed.ncbi.nlm.nih.gov/42421687/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42653475,Iron Oxide Nanozyme for Magnetothermal Activation of ER-TRPV1 Enables Efficient Intravesical Therapy of Bladder Cancer.,2026,10.3390/ijms27167475,https://pubmed.ncbi.nlm.nih.gov/42653475/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42875643,The dual role of capsaicin in inflammatory bowel disease: from TRPV1-mediated protection to neurogenic inflammation.,2026,10.1007/s10787-026-02426-9,https://pubmed.ncbi.nlm.nih.gov/42875643/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,41535811,Pan-cancer analysis of TRPV1: a novel immune infiltration-related biomarker for tumor prognosis and immunotherapy response prediction.,2026,10.1186/s12885-026-15576-4,https://pubmed.ncbi.nlm.nih.gov/41535811/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,41726657,T Cell Receptor Co-Stimulation Through Magnetogenetic Tools: A Platform for Wireless Rewiring of Cellular Signaling.,2026,10.1021/acsomega.5c10000,https://pubmed.ncbi.nlm.nih.gov/41726657/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42706754,Nanocatalytic Phase Separation Augments Tumor-specific cGAS-STING Activation for Spinal Metastasized Breast Cancer Metalloimmunotherapy.,2026,10.1002/adhm.71684,https://pubmed.ncbi.nlm.nih.gov/42706754/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42623749,Sublethal oral exposure to the marine toxin PbTx3: Neurotoxicity assessment in mice.,2026,10.1016/j.ecoenv.2026.120682,https://pubmed.ncbi.nlm.nih.gov/42623749/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42155176,X-ray programmable interleukin-12 expression via a Ca&lt;sup&gt;2+&lt;/sup&gt; signaling-gated nanoplasmid system for cancer immunotherapy.,2026,10.1016/j.biomaterials.2026.124308,https://pubmed.ncbi.nlm.nih.gov/42155176/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,41552596,The Role of TRPV1 Channel in Cosmetic Safety Evaluation.,2026,10.1021/acsomega.5c10830,https://pubmed.ncbi.nlm.nih.gov/41552596/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,42788080,Precision acupuncture for chemotherapy-induced peripheral neuropathy: multitarget mechanisms and integrated clinical translation framework.,2026,10.3389/fneur.2026.1855553,https://pubmed.ncbi.nlm.nih.gov/42788080/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,14987252,"Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures.",2004,10.1111/j.0906-6705.2004.0178.x,https://pubmed.ncbi.nlm.nih.gov/14987252/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,11243859,The tissue distribution and functional characterization of human VR1.,2001,10.1006/bbrc.2001.4482,https://pubmed.ncbi.nlm.nih.gov/11243859/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TRPV1,ENSG00000196689,Unsafe,11050376,Cloning and functional expression of a human orthologue of rat vanilloid receptor-1.,2000,10.1016/s0304-3959(00)00353-5,https://pubmed.ncbi.nlm.nih.gov/11050376/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSACC,ENSG00000163467,Unsafe,33732283,The Novel Key Genes of Non-obstructive Azoospermia Affect Spermatogenesis: Transcriptomic Analysis Based on RNA-Seq and scRNA-Seq Data.,2021,10.3389/fgene.2021.608629,https://pubmed.ncbi.nlm.nih.gov/33732283/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSACC,ENSG00000163467,Unsafe,31671693,Novel Mutations Segregating with Complete Androgen Insensitivity Syndrome and their Molecular Characteristics.,2019,10.3390/ijms20215418,https://pubmed.ncbi.nlm.nih.gov/31671693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSACC,ENSG00000163467,Unsafe,20829357,Identification of a novel HSP70-binding cochaperone critical to HSP90-mediated activation of small serine/threonine kinase.,2010,10.1074/jbc.m110.134767,https://pubmed.ncbi.nlm.nih.gov/20829357/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,41864117,RHOXF1/TSGA10 axis: a possible molecular mechanism of carcinogenesis.,2026,10.1016/j.ctarc.2026.101183,https://pubmed.ncbi.nlm.nih.gov/41864117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,42899482,Tumour Antigen-Specific Antibody Signatures as Diagnostic Biomarkers for Melanoma.,2026,10.1002/ijc.70726,https://pubmed.ncbi.nlm.nih.gov/42899482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,40507237,TSGA10 as a Model of a Thermal Metabolic Regulator: Implications for Cancer Biology.,2025,10.3390/cancers17111756,https://pubmed.ncbi.nlm.nih.gov/40507237/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,41836594,"Methylation and Expression Analysis of POU4F2, HOXA9, RBM46, and TSGA10 Genes in Bladder Cancer Using Methyl-Sensitive Restriction Enzyme PCR (MSRE-PCR).",2026,10.2147/cmar.s557943,https://pubmed.ncbi.nlm.nih.gov/41836594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,39744514,Prediction the functional impacts of highly deleterious non-synonymous variants of TSGA10 gene.,2025,10.22099/mbrc.2024.49991.1977,https://pubmed.ncbi.nlm.nih.gov/39744514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,39272902,Exploring TSGA10 Function: A Crosstalk or Controlling Mechanism in the Signaling Pathway of Carcinogenesis?,2024,10.3390/cancers16173044,https://pubmed.ncbi.nlm.nih.gov/39272902/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,40567906,"Chrysin's protective effect on the expression of &lt;i&gt;protamine&lt;/i&gt;, &lt;i&gt;Tsga10&lt;/i&gt;, &lt;i&gt;Dazl&lt;/i&gt;, and &lt;i&gt;Akap4&lt;/i&gt; genes against diazinon toxin in male rats: An experimental study.",2025,10.18502/ijrm.v23i3.18778,https://pubmed.ncbi.nlm.nih.gov/40567906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,42192970,Mitochondrial Hijacking and MicroRNA Crosstalk: Cancer Stem Cell-Mediated Immune Evasion and Metabolic Plasticity in the Tumor Microenvironment.,2026,10.3390/cancers18101611,https://pubmed.ncbi.nlm.nih.gov/42192970/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,36860313,Identification of TSGA10 and GGNBP2 splicing variants in 5' untranslated region with distinct expression profiles in brain tumor samples.,2023,10.3389/fonc.2023.1075638,https://pubmed.ncbi.nlm.nih.gov/36860313/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,38317066,A novel homozygous TSGA10 missense variant causes acephalic spermatozoa syndrome in a Pakistani family.,2024,10.1186/s12610-024-00220-7,https://pubmed.ncbi.nlm.nih.gov/38317066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,40349371,miR-508-5p regulates macrophage polarization via targeting TSGA10 to promote malignant behavior in esophageal cancer cells.,2026,10.1080/15257770.2025.2491561,https://pubmed.ncbi.nlm.nih.gov/40349371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,42069234,Impact of 5-alpha reductase inhibitors on male reproductive health: A review of finasteride and dutasteride.,2026,10.1016/j.reprotox.2026.109257,https://pubmed.ncbi.nlm.nih.gov/42069234/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,34409526,Pathogenesis of acephalic spermatozoa syndrome caused by splicing mutation and de novo deletion in TSGA10.,2021,10.1007/s10815-021-02295-x,https://pubmed.ncbi.nlm.nih.gov/34409526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,36718663,Retracted: Expression of Testis-Specific Gene Antigen 10 (TSGA10) is Associated with Apoptosis and Cell Migration in Bladder Cancer Cells and Tumor Stage and Overall Survival in Patients with Bladder Cancer.,2023,10.12659/msm.939596,https://pubmed.ncbi.nlm.nih.gov/36718663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,37670815,Transcriptomic signatures for human male infertility.,2023,10.3389/fmolb.2023.1226829,https://pubmed.ncbi.nlm.nih.gov/37670815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,34232471,TSGA10 as a Potential Key Factor in the Process of Spermatid Differentiation/Maturation: Deciphering Its Association with Autophagy Pathway.,2021,10.1007/s43032-021-00648-6,https://pubmed.ncbi.nlm.nih.gov/34232471/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,40376536,Establishment and clinical significance of genetic factor screening method for patients with nonobstructive azoospermia based on whole exon sequencing technology.,2025,10.21037/tau-2024-676,https://pubmed.ncbi.nlm.nih.gov/40376536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,37505071,"The constructive and destructive impact of autophagy on both genders' reproducibility, a comprehensive review.",2023,10.1080/15548627.2023.2238577,https://pubmed.ncbi.nlm.nih.gov/37505071/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,36386800,Identification of genes related to sexual differentiation and sterility in embryonic gonads of Mule ducks by transcriptome analysis.,2022,10.3389/fgene.2022.1037810,https://pubmed.ncbi.nlm.nih.gov/36386800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,31310599,Expression of Testis-Specific Gene Antigen 10 (TSGA10) is Associated with Apoptosis and Cell Migration in Bladder Cancer Cells and Tumor Stage and Overall Survival in Patients with Bladder Cancer.,2019,10.12659/msm.915682,https://pubmed.ncbi.nlm.nih.gov/31310599/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,31508330,Functional expression and impact of testis-specific gene antigen 10 in breast cancer: a combined in vitro and in silico analysis.,2019,10.15171/bi.2019.19,https://pubmed.ncbi.nlm.nih.gov/31508330/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,23396665,"Expression of Testis Specific Genes TSGA10, TEX101 and ODF3 in Breast Cancer.",2012,10.5812/ircmj.3611,https://pubmed.ncbi.nlm.nih.gov/23396665/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,30464633,Urine exosome gene expression of cancer-testis antigens for prediction of bladder carcinoma.,2018,10.2147/cmar.s180389,https://pubmed.ncbi.nlm.nih.gov/30464633/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,16406020,"Expression of the testis-specific gene, TSGA10, in Iranian patients with acute lymphoblastic leukemia (ALL).",2006,10.1016/j.leukres.2005.11.012,https://pubmed.ncbi.nlm.nih.gov/16406020/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,16120156,Identification of the testis-specific protein 10 (TSGA10) as serologically defined tumour-associated antigen in primary cutaneous T-cell lymphoma.,2005,10.1111/j.1365-2133.2005.06669.x,https://pubmed.ncbi.nlm.nih.gov/16120156/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,28905369,TSGA10 is a novel candidate gene associated with acephalic spermatozoa.,2018,10.1111/cge.13140,https://pubmed.ncbi.nlm.nih.gov/28905369/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,14585816,Tsga10 encodes a 65-kilodalton protein that is processed to the 27-kilodalton fibrous sheath protein.,2004,10.1095/biolreprod.103.021170,https://pubmed.ncbi.nlm.nih.gov/14585816/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSGA10,ENSG00000135951,Unsafe,11179690,"Identification and characterisation of a novel gene, TSGA10, expressed in testis.",2001,10.1016/s0378-1119(00)00519-9,https://pubmed.ncbi.nlm.nih.gov/11179690/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPAN16,ENSG00000130167,Unsafe,41347075,Construction and validation of a transmembrane 4 superfamily-related genes prognostic model for esophageal squamous cell carcinoma.,2025,10.3389/fonc.2025.1580199,https://pubmed.ncbi.nlm.nih.gov/41347075/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPAN16,ENSG00000130167,Unsafe,40070065,Development of a Novel 11-Gene Signature Related to Immune Subtypes for Fibromyalgia,2026,10.2174/0118715303365068250303042017,https://pubmed.ncbi.nlm.nih.gov/40070065/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPAN16,ENSG00000130167,Unsafe,35992081,The role of tetraspanins pan-cancer.,2022,10.1016/j.isci.2022.104777,https://pubmed.ncbi.nlm.nih.gov/35992081/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPAN16,ENSG00000130167,Unsafe,35207567,Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.,2022,10.3390/life12020280,https://pubmed.ncbi.nlm.nih.gov/35207567/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPAN16,ENSG00000130167,Unsafe,36568979,Potential diagnostic of lymph node metastasis and prognostic values of TM4SFs in papillary thyroid carcinoma patients.,2022,10.3389/fcell.2022.1001954,https://pubmed.ncbi.nlm.nih.gov/36568979/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPAN16,ENSG00000130167,Unsafe,31703168,Integrated Multiomics Approach to Identify Genetic Underpinnings of Heart Failure and Its Echocardiographic Precursors: Framingham Heart Study.,2019,10.1161/circgen.118.002489,https://pubmed.ncbi.nlm.nih.gov/31703168/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSPAN16,ENSG00000130167,Unsafe,17312329,Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias.,2007,10.1200/jco.2006.09.3534,https://pubmed.ncbi.nlm.nih.gov/17312329/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,41614612,Impacts of testis-specific serine/threonine protein kinase 3 on eupyrene spermatogenesis and contributes to male sterility in Plutella xylostella.,2026,10.1002/ps.70590,https://pubmed.ncbi.nlm.nih.gov/41614612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,42025703,GLUL deficiency causes sperm acrosome defects and male infertility via influencing redox balance in mice.,2026,10.1016/j.freeradbiomed.2026.04.030,https://pubmed.ncbi.nlm.nih.gov/42025703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,40884870,Construction and differential analysis of testicular atlas between 10-week-old and 23-week-old ducks using single-cell RNA sequencing.,2025,10.1016/j.psj.2025.105715,https://pubmed.ncbi.nlm.nih.gov/40884870/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,40305308,Identification of TSSK1 and TSSK2 as Novel Targets for Male Contraception.,2025,10.3390/biom15040601,https://pubmed.ncbi.nlm.nih.gov/40305308/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,36306217,Testis-specific serine kinase 3 is required for sperm morphogenesis and male fertility.,2023,10.1111/andr.13314,https://pubmed.ncbi.nlm.nih.gov/36306217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,37550055,Expression of Testis-specific Serine/Threonine Kinases during the Reproductive and Nonreproductive Seasons and Their Localization in Mature Spermatozoa of Tree Shrews (Tupaia belangeri).,2023,10.30802/aalas-cm-23-000043,https://pubmed.ncbi.nlm.nih.gov/37550055/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,38714941,Characterization of sexual maturity-associated N6-methyladenosine in boar testes.,2024,10.1186/s12864-024-10343-w,https://pubmed.ncbi.nlm.nih.gov/38714941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,34623009,"TSSK3, a novel target for male contraception, is required for spermiogenesis.",2021,10.1002/mrd.23539,https://pubmed.ncbi.nlm.nih.gov/34623009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,39855482,Comprehensive analysis of the transcriptome-wide m6A Methylome in sheep testicular development.,2025,10.1016/j.ygeno.2025.111005,https://pubmed.ncbi.nlm.nih.gov/39855482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,33765466,"cDNA cloning, expression and bioinformatical analysis of Tssk genes in tree shrews.",2021,10.1016/j.compbiolchem.2021.107474,https://pubmed.ncbi.nlm.nih.gov/33765466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,38631127,Gonadal transcriptome analysis of genes related to sex differentiation and sex development in the Pomacea canaliculata.,2024,10.1016/j.cbd.2024.101235,https://pubmed.ncbi.nlm.nih.gov/38631127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,36899892,miRNA Expression Profiles of Mouse Round Spermatids in GRTH/DDX25-Mediated Spermiogenesis: mRNA-miRNA Network Analysis.,2023,10.3390/cells12050756,https://pubmed.ncbi.nlm.nih.gov/36899892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,33859575,Expression of the Testis-Specific Serine/Threonine Kinases Suggests Their Role in Spermiogenesis of Bay Scallop Argopecten irradians.,2021,10.3389/fphys.2021.657559,https://pubmed.ncbi.nlm.nih.gov/33859575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,34537014,KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases.,2021,10.1186/s12859-021-04358-3,https://pubmed.ncbi.nlm.nih.gov/34537014/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,26600552,"Cloning, sequence characterization, and expression patterns of members of the porcine TSSK family.",2015,10.4238/2015.october.18.56,https://pubmed.ncbi.nlm.nih.gov/26600552/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,31955635,Comparative proteomics reveals protective effect of resveratrol on a high-fat diet-induced damage to mice testis.,2020,10.1080/19396368.2019.1701138,https://pubmed.ncbi.nlm.nih.gov/31955635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,28952188,Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinase 2 (TSSK2).,2017,10.1002/cmdc.201700503,https://pubmed.ncbi.nlm.nih.gov/28952188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,20729278,Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis.,2011,10.1093/molehr/gaq071,https://pubmed.ncbi.nlm.nih.gov/20729278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,23054012,Testis specific serine/threonine kinase 4 (Tssk4) maintains its kinase activity by phosphorylating itself at Thr-197.,2013,10.1007/s11033-012-2078-x,https://pubmed.ncbi.nlm.nih.gov/23054012/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TSSK3,ENSG00000162526,Unsafe,16336268,Characterization of testis-specific serine-threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling.,2005,10.1111/j.1742-4658.2005.05018.x,https://pubmed.ncbi.nlm.nih.gov/16336268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC16,ENSG00000167094,Unsafe,40822862,Multiomics Identifies Potential Biomarkers in Ankylosing Spondylitis Bone Formation.,2025,10.1155/humu/8771129,https://pubmed.ncbi.nlm.nih.gov/40822862/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC16,ENSG00000167094,Unsafe,40187068,Novel genetic associations with childhood adipocytokines in Indian adolescents.,2025,10.1016/j.cyto.2025.156935,https://pubmed.ncbi.nlm.nih.gov/40187068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC16,ENSG00000167094,Unsafe,38948080,Mass spectrometry-based proteomic profiling of extracellular vesicle proteins in diabetic and non-diabetic ischemic stroke patients: a case-control study.,2024,10.3389/fmolb.2024.1387859,https://pubmed.ncbi.nlm.nih.gov/38948080/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC16,ENSG00000167094,Unsafe,39884456,Multiomic Sequencing of Intermediate- to High-Risk Cutaneous Squamous Cell Carcinoma Identifies Critical Genes and Expression Patterns Associated with Disease and Poor Outcomes.,2025,10.1016/j.jid.2025.01.015,https://pubmed.ncbi.nlm.nih.gov/39884456/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC16,ENSG00000167094,Unsafe,38728468,NR1I2 as a core biological target in chronic venous ulcer tissues treated with ultrasound therapy.,2024,10.1097/md.0000000000038092,https://pubmed.ncbi.nlm.nih.gov/38728468/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC16,ENSG00000167094,Unsafe,40115909,Development of a prognostic risk model for colorectal cancer and association of the prognostic model with cancer stem cell and immune cell infiltration.,2025,10.21037/jgo-2024-985,https://pubmed.ncbi.nlm.nih.gov/40115909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC21A,ENSG00000168026,Unsafe,42791792,Genome-Wide Analysis of DNA Methylation Profiles on Jining Grey Goat Uterus Associated with Prolificacy Using Whole-Genome Bisulfite Sequencing.,2026,10.3390/ani16182935,https://pubmed.ncbi.nlm.nih.gov/42791792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC21A,ENSG00000168026,Unsafe,42723515,Ballelic Variants of TTC-Related Genes Cause Asthenoteratozoospermia With Favorable Clinical Outcomes After ICSI.,2026,10.1111/andr.70361,https://pubmed.ncbi.nlm.nih.gov/42723515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC21A,ENSG00000168026,Unsafe,38151293,Identification of TTC21A as a Potential Prognostic Marker in Head and Neck Squamous Cell Carcinoma: In Silico Analysis.,2024,10.21873/cgp.20428,https://pubmed.ncbi.nlm.nih.gov/38151293/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC21A,ENSG00000168026,Unsafe,35706814,High expression of TTC21A predict poor prognosis of colorectal cancer and influence the immune infiltrating level.,2022,10.21037/tcr-21-2674,https://pubmed.ncbi.nlm.nih.gov/35706814/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC21A,ENSG00000168026,Unsafe,36406111,High expression of TTC21A predicts unfavorable prognosis and immune infiltrates in clear cell renal cell carcinoma.,2022,10.3389/fgene.2022.967378,https://pubmed.ncbi.nlm.nih.gov/36406111/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC21A,ENSG00000168026,Unsafe,37383223,Screening biomarkers for Sjogren's Syndrome by computer analysis and evaluating the expression correlations with the levels of immune cells.,2023,10.3389/fimmu.2023.1023248,https://pubmed.ncbi.nlm.nih.gov/37383223/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC21A,ENSG00000168026,Unsafe,40376536,Establishment and clinical significance of genetic factor screening method for patients with nonobstructive azoospermia based on whole exon sequencing technology.,2025,10.21037/tau-2024-676,https://pubmed.ncbi.nlm.nih.gov/40376536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC21A,ENSG00000168026,Unsafe,39267058,Whole exome sequencing analysis of 167 men with primary infertility.,2024,10.1186/s12920-024-02005-3,https://pubmed.ncbi.nlm.nih.gov/39267058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC21A,ENSG00000168026,Unsafe,36756949,Absence of CEP78 causes photoreceptor and sperm flagella impairments in mice and a human individual.,2023,10.7554/elife.76157,https://pubmed.ncbi.nlm.nih.gov/36756949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC21A,ENSG00000168026,Unsafe,30929735,Bi-allelic Mutations in TTC21A Induce Asthenoteratospermia in Humans and Mice.,2019,10.1016/j.ajhg.2019.02.020,https://pubmed.ncbi.nlm.nih.gov/30929735/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC21A,ENSG00000168026,Unsafe,31812070,Increased expression of TTC21A in lung adenocarcinoma infers favorable prognosis and high immune infiltrating level.,2020,10.1016/j.intimp.2019.106077,https://pubmed.ncbi.nlm.nih.gov/31812070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC21A,ENSG00000168026,Unsafe,33345186,The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.,2020,10.1093/braincomms/fcaa176,https://pubmed.ncbi.nlm.nih.gov/33345186/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC21A,ENSG00000168026,Unsafe,32167205,"Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis.",2020,10.1096/fj.201902611r,https://pubmed.ncbi.nlm.nih.gov/32167205/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC21A,ENSG00000168026,Unsafe,35254116,"System analysis of FHIT in LUAD and LUSC: The expression, prognosis, gene regulation network, and regulation targets.",2022,10.1177/03936155221084056,https://pubmed.ncbi.nlm.nih.gov/35254116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC21A,ENSG00000168026,Unsafe,32636717,The plasma peptides of sepsis.,2020,10.1186/s12014-020-09288-5,https://pubmed.ncbi.nlm.nih.gov/32636717/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC21A,ENSG00000168026,Unsafe,24977159,Epigenetic alterations of chromosome 3 revealed by NotI-microarrays in clear cell renal cell carcinoma.,2014,10.1155/2014/735292,https://pubmed.ncbi.nlm.nih.gov/24977159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC21A,ENSG00000168026,Unsafe,10965040,Substrate specificity analysis of microbial transglutaminase using proteinaceous protease inhibitors as natural model substrates.,2000,10.1093/oxfordjournals.jbchem.a022769,https://pubmed.ncbi.nlm.nih.gov/10965040/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC21A,ENSG00000168026,Unsafe,12543795,An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies.,2003,,https://pubmed.ncbi.nlm.nih.gov/12543795/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC29,ENSG00000137473,Unsafe,42756534,A novel frameshift variant in &lt;i&gt;TTC29&lt;/i&gt; associated with total asthenozoospermia and male infertility.,2026,10.3389/fcell.2026.1937470,https://pubmed.ncbi.nlm.nih.gov/42756534/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC29,ENSG00000137473,Unsafe,42723515,Ballelic Variants of TTC-Related Genes Cause Asthenoteratozoospermia With Favorable Clinical Outcomes After ICSI.,2026,10.1111/andr.70361,https://pubmed.ncbi.nlm.nih.gov/42723515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC29,ENSG00000137473,Unsafe,39066891,ZMYND12 serves as an IDAd subunit that is essential for sperm motility in mice.,2024,10.1007/s00018-024-05344-7,https://pubmed.ncbi.nlm.nih.gov/39066891/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC29,ENSG00000137473,Unsafe,37934199,"Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function.",2023,10.7554/elife.87698,https://pubmed.ncbi.nlm.nih.gov/37934199/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC29,ENSG00000137473,Unsafe,36346162,Novel biallelic mutations in TTC29 cause asthenoteratospermia and male infertility.,2022,10.1002/mgg3.2078,https://pubmed.ncbi.nlm.nih.gov/36346162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC29,ENSG00000137473,Unsafe,41834962,[Whole Exome Sequencing Identified Novel Pathogenic Mutations of &lt;i&gt;ADGB&lt;/i&gt; in Patients With Oligoasthenozoospermia].,2026,10.12182/20260160108,https://pubmed.ncbi.nlm.nih.gov/41834962/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC29,ENSG00000137473,Unsafe,39774243,Genomic evidence of improved fertility and adaptation in Iranian domestic sheep attributed to introgression from Asiatic Mouflon and urial.,2025,10.1038/s41598-025-85756-y,https://pubmed.ncbi.nlm.nih.gov/39774243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC29,ENSG00000137473,Unsafe,31735294,Bi-allelic Mutations in TTC29 Cause Male Subfertility with Asthenoteratospermia in Humans and Mice.,2019,10.1016/j.ajhg.2019.10.010,https://pubmed.ncbi.nlm.nih.gov/31735294/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC29,ENSG00000137473,Unsafe,38540412,Genome-Wide DNA Methylation Analysis and Functional Validation of Litter Size Traits in Jining Grey Goats.,2024,10.3390/genes15030353,https://pubmed.ncbi.nlm.nih.gov/38540412/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC29,ENSG00000137473,Unsafe,31735292,"Mutations in TTC29, Encoding an Evolutionarily Conserved Axonemal Protein, Result in Asthenozoospermia and Male Infertility.",2019,10.1016/j.ajhg.2019.10.007,https://pubmed.ncbi.nlm.nih.gov/31735292/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC29,ENSG00000137473,Unsafe,33342769,Gene Expression Profiling in the Striatum of Per2 KO Mice Exhibiting More Vulnerable Responses against Methamphetamine.,2021,10.4062/biomolther.2020.123,https://pubmed.ncbi.nlm.nih.gov/33342769/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC29,ENSG00000137473,Unsafe,22878202,Regulation of rat tetratricopeptide repeat domain 29 gene expression by follicle-stimulating hormone.,2012,10.1271/bbb.120293,https://pubmed.ncbi.nlm.nih.gov/22878202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC29,ENSG00000137473,Unsafe,32034058,Integrated characterisation of cancer genes identifies key molecular biomarkers in stomach adenocarcinoma.,2020,10.1136/jclinpath-2019-206400,https://pubmed.ncbi.nlm.nih.gov/32034058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC29,ENSG00000137473,Unsafe,32655616,Integrating Genome-Wide CNVs Into QTLs and High Confidence GWAScore Regions Identified Positional Candidates for Sheep Economic Traits.,2020,10.3389/fgene.2020.00569,https://pubmed.ncbi.nlm.nih.gov/32655616/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC29,ENSG00000137473,Unsafe,25250046,Genome-wide association and pathway analysis of feed efficiency in pigs reveal candidate genes and pathways for residual feed intake.,2014,10.3389/fgene.2014.00307,https://pubmed.ncbi.nlm.nih.gov/25250046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTC29,ENSG00000137473,Unsafe,34529793,"Genetic diagnosis, sperm phenotype and ICSI outcome in case of severe asthenozoospermia with multiple morphological abnormalities of the flagellum.",2021,10.1093/humrep/deab200,https://pubmed.ncbi.nlm.nih.gov/34529793/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42189826,TTK Overexpression as a Prognostic Indicator and Immune Modulator in Kidney Renal Clear Cell Carcinoma.,2026,10.1002/mc.70132,https://pubmed.ncbi.nlm.nih.gov/42189826/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,41790678,The expression of tyrosine kinase and threonine promotes the progression of lung adenocarcinoma and is linked to a negative prognosis.,2026,10.1097/md.0000000000047882,https://pubmed.ncbi.nlm.nih.gov/41790678/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42289641,TTK Overexpression: A Negative Prognostic Biomarker in Anaplastic Thyroid Carcinoma.,2026,10.1002/cam4.71995,https://pubmed.ncbi.nlm.nih.gov/42289641/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42793322,Chromosomal Heterogeneity and Enrichment of Mitotic Regulatory Programs Reveal a Therapeutic Vulnerability in Cytarabine-Resistant FLT3-ITD AML.,2026,10.3390/cimb48090966,https://pubmed.ncbi.nlm.nih.gov/42793322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,40499340,Targeting monopolar spindle kinase I (Mps1 or TTK) induces radiosensitization in syngeneic models of triple negative breast cancer (TNBC) and potentiates type I interferon (T1IFN) signaling.,2025,10.1016/j.neo.2025.101190,https://pubmed.ncbi.nlm.nih.gov/40499340/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42309608,Phosphosite-specific co-regulation networks of MELK kinase: insights from integrative global phosphoproteomes.,2026,10.1016/j.jgeb.2026.100705,https://pubmed.ncbi.nlm.nih.gov/42309608/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42641883,Rewiring mitotic checkpoint control via Mps1 inhibition overcomes DNA repair-mediated resistance in glioblastoma.,2026,10.1016/j.jbc.2026.113487,https://pubmed.ncbi.nlm.nih.gov/42641883/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42122120,NFYA-Mediated TTK Up-Regulation Drives Fast Cell Cycle Progression and Its Inhibition Leads to Mitotic Catastrophe in Triple Negative Breast Cancer.,2026,10.3390/cancers18091324,https://pubmed.ncbi.nlm.nih.gov/42122120/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,39668392,Identifying Anti-cancer Effects and Exploring the Mechanism of an MPS1/TTK Inhibitor in Gastric Cancer.,2025,10.4143/crt.2024.780,https://pubmed.ncbi.nlm.nih.gov/39668392/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42647139,Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small Cell Lung Cancer.,2026,10.1158/2767-9764.crc-26-0560,https://pubmed.ncbi.nlm.nih.gov/42647139/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,41697437,Disconnect between in vitro and in vivo efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma.,2026,10.1007/s13402-026-01175-9,https://pubmed.ncbi.nlm.nih.gov/41697437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42461244,Kinetochore clustering is mediated by Mps1 phosphorylation of conserved MELT motifs in Stu1.,2026,10.1083/jcb.202601143,https://pubmed.ncbi.nlm.nih.gov/42461244/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,40332247,Reduction in Gonad Development and Sperm Motility in Male Brown Planthopper &lt;i&gt;Nilaparvata lugens&lt;/i&gt; via RNAi-Mediated Knockdown of &lt;i&gt;tramtrack&lt;/i&gt;.,2025,10.3390/ijms26083643,https://pubmed.ncbi.nlm.nih.gov/40332247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,41482351,Mechanistic Insights into Threonine Tyrosine Kinase Mediated Cell Cycle Regulation in Triple-negative Breast Cancer.,2026,10.21873/cgp.20563,https://pubmed.ncbi.nlm.nih.gov/41482351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42188182,Genome-Wide Identification of Transcriptional Start Sites and Candidate Enhancers Regulating Worker Metamorphosis in &lt;i&gt;Apis mellifera&lt;/i&gt;.,2026,10.3390/insects17050516,https://pubmed.ncbi.nlm.nih.gov/42188182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,38904203,Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer.,2024,10.3892/or.2024.8760,https://pubmed.ncbi.nlm.nih.gov/38904203/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42449121,Defining a ketone threshold for weight loss: evidence from 14 day daily β-hydroxybutyrate monitoring in 217 subjects on a ketogenic diet.,2026,10.1038/s41387-026-00454-6,https://pubmed.ncbi.nlm.nih.gov/42449121/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42247986,Computational exploration of quercetin derivatives from Azadirachta indica leaf as threonine tyrosine kinase inhibitors for potential lung and pancreatic cancer treatment.,2026,10.1016/j.compbiolchem.2026.109159,https://pubmed.ncbi.nlm.nih.gov/42247986/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,40269198,TTK promotes mitophagy by regulating ULK1 phosphorylation and pre-mRNA splicing to inhibit mitochondrial apoptosis in bladder cancer.,2025,10.1038/s41418-025-01492-w,https://pubmed.ncbi.nlm.nih.gov/40269198/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42906557,Dynamic roles of embryonic glial cells in octopus brain development.,2026,10.1016/j.cub.2026.09.068,https://pubmed.ncbi.nlm.nih.gov/42906557/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42909643,MPS1 inhibition as an anticancer strategy: where do we stand?,2026,10.1007/s10577-026-09821-6,https://pubmed.ncbi.nlm.nih.gov/42909643/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42893099,Integrated Transcriptomic and Single-Cell Analyses Identify a T Cell-Mediated Tumor Killing Gene Signature for Prognostic Stratification and Immune Characterization in Breast Cancer.,2026,10.2147/ijwh.s628386,https://pubmed.ncbi.nlm.nih.gov/42893099/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42076055,"Mitotic Machinery Dysregulation in Lung Cancer: Biological Roles, Therapeutic Targeting, and Combination Strategies.",2026,10.3390/pharmaceutics18040402,https://pubmed.ncbi.nlm.nih.gov/42076055/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,41603185,Prediction of Clinical Outcomes and Immunotherapy Response in Breast Cancer Based on T Cell-Mediated Tumor Killing-Related Traits.,2026,10.2174/0118715303429021251024053150,https://pubmed.ncbi.nlm.nih.gov/41603185/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,41516322,Overcoming Therapeutic Resistance in Triple-Negative Breast Cancer: Targeting the Undrugged Kinome.,2025,10.3390/ijms27010450,https://pubmed.ncbi.nlm.nih.gov/41516322/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42257923,"Comparative evaluation of bipolar versus monopolar energy platforms in G-POEM for gastroparesis: technical performance, learning curves, and clinical outcomes.",2026,10.1007/s00464-026-12746-0,https://pubmed.ncbi.nlm.nih.gov/42257923/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,38900577,TTK inhibitor OSU13 promotes immunotherapy responses by activating tumor STING.,2024,10.1172/jci.insight.177523,https://pubmed.ncbi.nlm.nih.gov/38900577/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42140164,cGAS-STING Signalling in the tumour microenvironment: Implications for immune surveillance and therapeutic strategies.,2026,10.1016/j.intimp.2026.116832,https://pubmed.ncbi.nlm.nih.gov/42140164/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42507215,Characterizing risk groups in papillary thyroid carcinoma through T-Cell mediated tumor cell killing-related genes: a pathway to therapeutic predictions.,2026,10.1007/s00405-026-10470-y,https://pubmed.ncbi.nlm.nih.gov/42507215/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTK,ENSG00000112742,Unsafe,42039207,Comprehensive analysis of prognostic characteristics based on T cell-mediated tumor killing related genes in triple negative breast cancer.,2026,10.3389/fimmu.2026.1801004,https://pubmed.ncbi.nlm.nih.gov/42039207/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL10,ENSG00000162571,Unsafe,42737678,A Comparative Analysis of the Methylation Status of Non-Coding RNA Promoters in Fibroid and Matched Myometrium.,2026,10.3390/ijms27177781,https://pubmed.ncbi.nlm.nih.gov/42737678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL10,ENSG00000162571,Unsafe,42351650,A Gene Feature Based on Histone Modifications Can Predict the Prognosis of Prostate Cancer.,2026,10.3390/biomedicines14061219,https://pubmed.ncbi.nlm.nih.gov/42351650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL10,ENSG00000162571,Unsafe,39554687,Identification of genetic risk variants for Type-2 Diabetes mellitus in Pakistani Pashtun population: A case-control association study.,2024,10.12669/pjms.40.10.10292,https://pubmed.ncbi.nlm.nih.gov/39554687/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL10,ENSG00000162571,Unsafe,18331838,TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein 1.,2008,10.1016/j.febslet.2008.02.079,https://pubmed.ncbi.nlm.nih.gov/18331838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL10,ENSG00000162571,Unsafe,26292219,Transcription Factor Hepatocyte Nuclear Factor-1β (HNF-1β) Regulates MicroRNA-200 Expression through a Long Noncoding RNA.,2015,10.1074/jbc.m115.670646,https://pubmed.ncbi.nlm.nih.gov/26292219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL10,ENSG00000162571,Unsafe,19427864,TTLL10 can perform tubulin glycylation when co-expressed with TTLL8.,2009,10.1016/j.febslet.2009.05.003,https://pubmed.ncbi.nlm.nih.gov/19427864/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL11,ENSG00000175764,Unsafe,40834096,Mechanistic insights into TTLL11 polyglutamylase-mediated primary tubulin chain elongation.,2025,10.1126/sciadv.adw1561,https://pubmed.ncbi.nlm.nih.gov/40834096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL11,ENSG00000175764,Unsafe,42624259,The molecular mechanisms and therapeutic targeting of microtubule glutamylation in mitosis and cancer.,2026,10.1016/j.pharmthera.2026.109100,https://pubmed.ncbi.nlm.nih.gov/42624259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL11,ENSG00000175764,Unsafe,41770829,"Expression of recombinant human glutamylating TTLLs in human cells leads to differential tubulin glutamylation patterns, with only TTLL6 disrupting microtubule dynamics.",2026,10.1371/journal.pone.0339922,https://pubmed.ncbi.nlm.nih.gov/41770829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL11,ENSG00000175764,Unsafe,39349846,Carboxy-terminal polyglutamylation regulates signaling and phase separation of the Dishevelled protein.,2024,10.1038/s44318-024-00254-7,https://pubmed.ncbi.nlm.nih.gov/39349846/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL11,ENSG00000175764,Unsafe,39966472,Doublecortin restricts neuronal branching by regulating tubulin polyglutamylation.,2025,10.1038/s41467-025-56951-2,https://pubmed.ncbi.nlm.nih.gov/39966472/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL11,ENSG00000175764,Unsafe,36511133,TTLL11 gene is associated with sustained attention performance and brain networks: A genome-wide association study of a healthy Chinese sample.,2023,10.1111/gbb.12835,https://pubmed.ncbi.nlm.nih.gov/36511133/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL11,ENSG00000175764,Unsafe,36414642,Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11.,2022,10.1038/s41467-022-34909-y,https://pubmed.ncbi.nlm.nih.gov/36414642/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL11,ENSG00000175764,Unsafe,39613968,Tubulin glutamylation regulates axon guidance via the selective tuning of microtubule-severing enzymes.,2025,10.1038/s44318-024-00307-x,https://pubmed.ncbi.nlm.nih.gov/39613968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL11,ENSG00000175764,Unsafe,34040021,Genetic variant of TTLL11 gene and subsequent ciliary defects are associated with idiopathic scoliosis in a 5-generation UK family.,2021,10.1038/s41598-021-90155-0,https://pubmed.ncbi.nlm.nih.gov/34040021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL11,ENSG00000175764,Unsafe,38259468,Pharmacogenomics of intravenous immunoglobulin response in Kawasaki disease.,2023,10.3389/fimmu.2023.1287094,https://pubmed.ncbi.nlm.nih.gov/38259468/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL11,ENSG00000175764,Unsafe,39920028,Characterization of tubulin post-translational modifications and their enzymes during human oocyte meiosis.,2025,10.1016/j.rbmo.2024.103885,https://pubmed.ncbi.nlm.nih.gov/39920028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL11,ENSG00000175764,Unsafe,34338422,Exome survey of individuals affected by VATER/VACTERL with renal phenotypes identifies phenocopies and novel candidate genes.,2021,10.1002/ajmg.a.62447,https://pubmed.ncbi.nlm.nih.gov/34338422/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL11,ENSG00000175764,Unsafe,32184465,Translation of mouse model to human gives insights into periodontitis etiology.,2020,10.1038/s41598-020-61819-0,https://pubmed.ncbi.nlm.nih.gov/32184465/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL11,ENSG00000175764,Unsafe,21302349,Inherited balanced translocation t(9;17)(q33.2;q25.3) concomitant with a 16p13.1 duplication in a patient with schizophrenia.,2011,10.1002/ajmg.b.31157,https://pubmed.ncbi.nlm.nih.gov/21302349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,41770829,"Expression of recombinant human glutamylating TTLLs in human cells leads to differential tubulin glutamylation patterns, with only TTLL6 disrupting microtubule dynamics.",2026,10.1371/journal.pone.0339922,https://pubmed.ncbi.nlm.nih.gov/41770829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,40202105,Repeated Exposure to Sevoflurane in Neonatal Mice Induces Cognitive and Synaptic Impairments in a TTLL6-Mediated Tubulin Polyglutamylation Manner.,2025,10.1111/cns.70376,https://pubmed.ncbi.nlm.nih.gov/40202105/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,42654155,Targeting TTLL1 Alleviates Aβ-Induced Microtubule Disruption and TAU Pathology in Human iPSC-Derived Cortical Neurons.,2026,10.3390/pharmaceutics18081038,https://pubmed.ncbi.nlm.nih.gov/42654155/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,42624259,The molecular mechanisms and therapeutic targeting of microtubule glutamylation in mitosis and cancer.,2026,10.1016/j.pharmthera.2026.109100,https://pubmed.ncbi.nlm.nih.gov/42624259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,42036012,Integrative analysis of lactylation patterns reveals prognostic biomarkers and therapeutic targets in pancreatic cancer.,2026,10.1016/j.canlet.2026.218536,https://pubmed.ncbi.nlm.nih.gov/42036012/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,38658656,Structural basis for α-tubulin-specific and modification state-dependent glutamylation.,2024,10.1038/s41589-024-01599-0,https://pubmed.ncbi.nlm.nih.gov/38658656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,35333353,XBP1 variant 1 promotes mitosis of cancer cells involving upregulation of the polyglutamylase TTLL6.,2022,10.1093/hmg/ddac010,https://pubmed.ncbi.nlm.nih.gov/35333353/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,39613968,Tubulin glutamylation regulates axon guidance via the selective tuning of microtubule-severing enzymes.,2025,10.1038/s44318-024-00307-x,https://pubmed.ncbi.nlm.nih.gov/39613968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,38596466,Proteomic analysis of the serum in dogs with pulmonary hypertension secondary to myxomatous mitral valve disease: the preliminary study.,2024,10.3389/fvets.2024.1327453,https://pubmed.ncbi.nlm.nih.gov/38596466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,33123270,Effect of TTLL6 expression on CDDP sensitivity of EC109/CDDP cells in hypoxia/acidosis microenvironment.,2020,10.7150/jca.47694,https://pubmed.ncbi.nlm.nih.gov/33123270/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,37181810,Identification of a New m6A Regulator-Related Methylation Signature for Predicting the Prognosis and Immune Microenvironment of Patients with Pancreatic Cancer.,2023,10.1155/2023/5565054,https://pubmed.ncbi.nlm.nih.gov/37181810/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,39920028,Characterization of tubulin post-translational modifications and their enzymes during human oocyte meiosis.,2025,10.1016/j.rbmo.2024.103885,https://pubmed.ncbi.nlm.nih.gov/39920028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,26691836,Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia.,2015,10.1186/s13024-015-0064-1,https://pubmed.ncbi.nlm.nih.gov/26691836/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,32747782,Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.,2020,10.1038/s41594-020-0462-0,https://pubmed.ncbi.nlm.nih.gov/32747782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,24065130,Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin.,2013,10.1038/emboj.2013.207,https://pubmed.ncbi.nlm.nih.gov/24065130/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,34791208,Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility.,2022,10.1093/g3journal/jkab394,https://pubmed.ncbi.nlm.nih.gov/34791208/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,30956117,Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes.,2019,10.1016/j.molmet.2019.03.004,https://pubmed.ncbi.nlm.nih.gov/30956117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,21262966,Tubulin tyrosine ligase-like genes ttll3 and ttll6 maintain zebrafish cilia structure and motility.,2011,10.1074/jbc.m110.209817,https://pubmed.ncbi.nlm.nih.gov/21262966/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,25332286,Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation.,2014,10.1084/jem.20141123,https://pubmed.ncbi.nlm.nih.gov/25332286/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL6,ENSG00000170703,Unsafe,30120249,Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules.,2018,10.1038/s41467-018-05867-1,https://pubmed.ncbi.nlm.nih.gov/30120249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL9,ENSG00000131044,Unsafe,39863862,Identification of novel cytoskeleton protein involved in spermatogenic cells and sertoli cells of non-obstructive azoospermia based on microarray and bioinformatics analysis.,2025,10.1186/s12920-025-02087-7,https://pubmed.ncbi.nlm.nih.gov/39863862/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL9,ENSG00000131044,Unsafe,38622589,Human genetic associations of the airway microbiome in chronic obstructive pulmonary disease.,2024,10.1186/s12931-024-02805-2,https://pubmed.ncbi.nlm.nih.gov/38622589/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL9,ENSG00000131044,Unsafe,34028060,Targeted sequencing reveals candidate causal variants for dairy bull subfertility.,2021,10.1111/age.13089,https://pubmed.ncbi.nlm.nih.gov/34028060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL9,ENSG00000131044,Unsafe,39920028,Characterization of tubulin post-translational modifications and their enzymes during human oocyte meiosis.,2025,10.1016/j.rbmo.2024.103885,https://pubmed.ncbi.nlm.nih.gov/39920028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL9,ENSG00000131044,Unsafe,27257088,"Ttll9-/- mice sperm flagella show shortening of doublet 7, reduction of doublet 5 polyglutamylation and a stall in beating.",2016,10.1242/jcs.185983,https://pubmed.ncbi.nlm.nih.gov/27257088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL9,ENSG00000131044,Unsafe,34280480,Different combinations of high-frequency rTMS and cognitive training improve the cognitive function of cerebral ischemic rats.,2021,10.1016/j.brainresbull.2021.07.012,https://pubmed.ncbi.nlm.nih.gov/34280480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL9,ENSG00000131044,Unsafe,24196831,"A conserved flagella-associated protein in Chlamydomonas, FAP234, is essential for axonemal localization of tubulin polyglutamylase TTLL9.",2014,10.1091/mbc.e13-07-0424,https://pubmed.ncbi.nlm.nih.gov/24196831/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL9,ENSG00000131044,Unsafe,26348919,A NIMA-Related Kinase Suppresses the Flagellar Instability Associated with the Loss of Multiple Axonemal Structures.,2015,10.1371/journal.pgen.1005508,https://pubmed.ncbi.nlm.nih.gov/26348919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL9,ENSG00000131044,Unsafe,18586949,Glutamylation on alpha-tubulin is not essential but affects the assembly and functions of a subset of microtubules in Tetrahymena thermophila.,2008,10.1128/ec.00084-08,https://pubmed.ncbi.nlm.nih.gov/18586949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TTLL9,ENSG00000131044,Unsafe,20188560,Tubulin polyglutamylation regulates axonemal motility by modulating activities of inner-arm dyneins.,2010,10.1016/j.cub.2009.12.058,https://pubmed.ncbi.nlm.nih.gov/20188560/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3D,ENSG00000075886,Unsafe,41047445,RNA sequence analysis of differentially expressed genes in left atrial appendage thrombus.,2026,10.1007/s11239-025-03184-1,https://pubmed.ncbi.nlm.nih.gov/41047445/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3D,ENSG00000075886,Unsafe,39286180,Epithelial cell-related prognostic risk model in breast cancer based on single-cell and bulk RNA sequencing.,2024,10.1016/j.heliyon.2024.e37048,https://pubmed.ncbi.nlm.nih.gov/39286180/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3D,ENSG00000075886,Unsafe,39432642,"Exploring the role of aggrephagy-related signatures in immune microenvironment, prognosis, and therapeutic strategies of breast cancer.",2024,10.1097/md.0000000000039999,https://pubmed.ncbi.nlm.nih.gov/39432642/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3D,ENSG00000075886,Unsafe,41953647,"Insight into genes responsible for cornea plana, megalocornea, keratoconus and brittle cornea syndrome.",2026,,https://pubmed.ncbi.nlm.nih.gov/41953647/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3D,ENSG00000075886,Unsafe,37346398,Exploring novel biomarkers in dilated cardiomyopathy‑induced heart failure by integrated analysis and in vitro experiments.,2023,10.3892/etm.2023.12024,https://pubmed.ncbi.nlm.nih.gov/37346398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3D,ENSG00000075886,Unsafe,37628602,Insights from a Computational-Based Approach for Analyzing Autophagy Genes across Human Cancers.,2023,10.3390/genes14081550,https://pubmed.ncbi.nlm.nih.gov/37628602/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3D,ENSG00000075886,Unsafe,39082332,An Apoptosis-Related Specific Risk Model for Breast Cancer: From Genomic Analysis to Precision Medicine.,2024,10.31083/j.fbl2907239,https://pubmed.ncbi.nlm.nih.gov/39082332/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3D,ENSG00000075886,Unsafe,35501919,Impact of neoadjuvant chemotherapy on somatic mutation status in high-grade serous ovarian carcinoma.,2022,10.1186/s13048-022-00983-5,https://pubmed.ncbi.nlm.nih.gov/35501919/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3D,ENSG00000075886,Unsafe,29051577,De novo mutations of TUBA3D are associated with keratoconus.,2017,10.1038/s41598-017-13162-0,https://pubmed.ncbi.nlm.nih.gov/29051577/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3D,ENSG00000075886,Unsafe,30423812,Role of Overexpressed Transcription Factor FOXO1 in Fatal Cardiovascular Septal Defects in Patau Syndrome: Molecular and Therapeutic Strategies.,2018,10.3390/ijms19113547,https://pubmed.ncbi.nlm.nih.gov/30423812/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3D,ENSG00000075886,Unsafe,29619247,Cardiac arrhythmia and neuroexcitability gene variants in resected brain tissue from patients with sudden unexpected death in epilepsy (SUDEP).,2018,10.1038/s41525-018-0048-5,https://pubmed.ncbi.nlm.nih.gov/29619247/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3E,ENSG00000152086,Unsafe,42343898,"Identification and multi-layered validation of seven diagnostic biomarkers for dilated cardiomyopathy via integrative machine learning, single-cell transcriptomics, and Mendelian randomization.",2026,10.3389/fcell.2026.1851275,https://pubmed.ncbi.nlm.nih.gov/42343898/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3E,ENSG00000152086,Unsafe,42275208,A spatial and temporal atlas of tubulin isotype gene expression during vertebrate embryonic development.,2026,10.1091/mbc.e26-03-0116,https://pubmed.ncbi.nlm.nih.gov/42275208/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3E,ENSG00000152086,Unsafe,39432642,"Exploring the role of aggrephagy-related signatures in immune microenvironment, prognosis, and therapeutic strategies of breast cancer.",2024,10.1097/md.0000000000039999,https://pubmed.ncbi.nlm.nih.gov/39432642/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3E,ENSG00000152086,Unsafe,37747033,Identification and validation of molecular subtypes and a 9-gene risk model for breast cancer.,2023,10.1097/md.0000000000035204,https://pubmed.ncbi.nlm.nih.gov/37747033/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3E,ENSG00000152086,Unsafe,36538967,Changes on proteomic and metabolomic profiling of cryopreserved sperm effected by melatonin.,2023,10.1016/j.jprot.2022.104791,https://pubmed.ncbi.nlm.nih.gov/36538967/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3E,ENSG00000152086,Unsafe,28487351,Gestational high-fat diet and bisphenol A exposure heightens mammary cancer risk.,2017,10.1530/erc-17-0006,https://pubmed.ncbi.nlm.nih.gov/28487351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBA3E,ENSG00000152086,Unsafe,25558065,Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families.,2015,10.1016/j.celrep.2014.12.015,https://pubmed.ncbi.nlm.nih.gov/25558065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,40701248,A novel protein encoded by circTUBGCP3 blocks ferroptosis and promotes gastric cancer progression.,2025,10.1016/j.jbc.2025.110507,https://pubmed.ncbi.nlm.nih.gov/40701248/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,42367068,Stage-Specific Expression and Perinuclear Enrichment of γ-Tubulin During Tomont Development and Theront Morphogenesis in Cryptocaryon irritans.,2026,10.1111/jeu.70106,https://pubmed.ncbi.nlm.nih.gov/42367068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,42092188,Mutation of Tubgcp6 induces hematopoietic stem and progenitor cell exhaustion in zebrafish.,2026,10.1038/s42003-026-10209-9,https://pubmed.ncbi.nlm.nih.gov/42092188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,41571964,Associations of air pollution and genetic risk and their interaction with risk of Alzheimer's disease: identification of risk loci and potential biological pathways.,2026,10.1007/s11357-026-02102-4,https://pubmed.ncbi.nlm.nih.gov/41571964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,40752182,Transcriptomic analysis unveils critical genes governing early development and sex differentiation in the Cipangopaludina chinensis (Gastropoda: Viviparidae).,2025,10.1016/j.cbd.2025.101590,https://pubmed.ncbi.nlm.nih.gov/40752182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,33482282,Tubgcp3 is a mitotic regulator of planarian epidermal differentiation.,2021,10.1016/j.gene.2021.145440,https://pubmed.ncbi.nlm.nih.gov/33482282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,40359387,Single-cell proteomics analysis of human oocytes during GV-to-MI transition.,2025,10.1093/humrep/deaf086,https://pubmed.ncbi.nlm.nih.gov/40359387/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,31178691,Tubgcp3 Is Required for Retinal Progenitor Cell Proliferation During Zebrafish Development.,2019,10.3389/fnmol.2019.00126,https://pubmed.ncbi.nlm.nih.gov/31178691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,40543334,Physiological and molecular responses to different sizes of polystyrene micro/nanoplastics in the model unicellular eukaryote Paramecium tetraurelia.,2025,10.1016/j.jhazmat.2025.138963,https://pubmed.ncbi.nlm.nih.gov/40543334/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,40074789,Structural mechanisms for centrosomal recruitment and organization of the microtubule nucleator γ-TuRC.,2025,10.1038/s41467-025-57729-2,https://pubmed.ncbi.nlm.nih.gov/40074789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,34696358,Potential Molecular Mechanisms of Rare Anti-Tumor Immune Response by SARS-CoV-2 in Isolated Cases of Lymphomas.,2021,10.3390/v13101927,https://pubmed.ncbi.nlm.nih.gov/34696358/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,38086550,The AP-2 complex interacts with γ-TuRC and regulates the proliferative capacity of neural progenitors.,2024,10.26508/lsa.202302029,https://pubmed.ncbi.nlm.nih.gov/38086550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,39663511,Insight Into Body Size Evolution in Aves: Based on Some Body Size-Related Genes.,2025,10.1111/1749-4877.12927,https://pubmed.ncbi.nlm.nih.gov/39663511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,35078983,Modular assembly of the principal microtubule nucleator γ-TuRC.,2022,10.1038/s41467-022-28079-0,https://pubmed.ncbi.nlm.nih.gov/35078983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,33458610,Autosomal recessive variants in &lt;i&gt;TUBGCP2&lt;/i&gt; alter the γ-tubulin ring complex leading to neurodevelopmental disease.,2021,10.1016/j.isci.2020.101948,https://pubmed.ncbi.nlm.nih.gov/33458610/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,26079448,Overexpression and Nucleolar Localization of γ-Tubulin Small Complex Proteins GCP2 and GCP3 in Glioblastoma.,2015,10.1097/nen.0000000000000212,https://pubmed.ncbi.nlm.nih.gov/26079448/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,35604367,Reconstitution and mechanistic dissection of the human microtubule branching machinery.,2022,10.1083/jcb.202109053,https://pubmed.ncbi.nlm.nih.gov/35604367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,29351804,A metastasized hepatocellular carcinoma in the capsule of an undescended testis in the right inguinal area: report of a rare case.,2018,10.1186/s12957-018-1319-4,https://pubmed.ncbi.nlm.nih.gov/29351804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,21908619,Molecular identification of β-citrylglutamate hydrolase as glutamate carboxypeptidase 3.,2011,10.1074/jbc.m111.287318,https://pubmed.ncbi.nlm.nih.gov/21908619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,32846968,Subcellular Localization and Mitotic Interactome Analyses Identify SIRT4 as a Centrosomally Localized and Microtubule Associated Protein.,2020,10.3390/cells9091950,https://pubmed.ncbi.nlm.nih.gov/32846968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TUBGCP3,ENSG00000126216,Unsafe,27149990,Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers.,2016,10.1242/dmm.025239,https://pubmed.ncbi.nlm.nih.gov/27149990/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,41965938,Methylation biomarkers in non-regressive cervical intraepithelial neoplasia grade 2 lesions: an epigenome wide association study.,2026,10.1038/s41416-026-03391-4,https://pubmed.ncbi.nlm.nih.gov/41965938/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,40828202,Bioinformatics and Experimental Validation of Diagnostic Marker Genes for Myocardial Infarction and Analysis of Their Immune Cell Infiltration.,2026,10.1007/s10528-025-11211-2,https://pubmed.ncbi.nlm.nih.gov/40828202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,35603654,[Preparation and application of rabbit polyclonal antibody against mouse Tubby-like protein 2 (TULP2)].,2022,,https://pubmed.ncbi.nlm.nih.gov/35603654/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,33763418,"TULP2, a New RNA-Binding Protein, Is Required for Mouse Spermatid Differentiation and Male Fertility.",2021,10.3389/fcell.2021.623738,https://pubmed.ncbi.nlm.nih.gov/33763418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,39944873,Nomogram construction based on characteristic genes and clinical variables to predict the risk of multiple organ dysfunction syndrome caused by influenza in children.,2025,10.21037/tp-24-386,https://pubmed.ncbi.nlm.nih.gov/39944873/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,35619658,TULP2 deletion mice exhibit abnormal outer dense fiber structure and male infertility.,2022,10.1002/rmb2.12467,https://pubmed.ncbi.nlm.nih.gov/35619658/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,40837069,Genome-Wide Association Study and Rare Variant Association Studies of Strabismus in the &lt;i&gt;All of Us&lt;/i&gt; Research Program.,2025,10.1016/j.xops.2025.100873,https://pubmed.ncbi.nlm.nih.gov/40837069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,36650547,A novel homozygous TUB mutation associated with autosomal recessive retinitis pigmentosa in a consanguineous Chinese family.,2023,10.1186/s12920-023-01430-0,https://pubmed.ncbi.nlm.nih.gov/36650547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,34462398,Differential Roles of Tubby Family Proteins in Ciliary Formation and Trafficking.,2021,10.14348/molcells.2021.0082,https://pubmed.ncbi.nlm.nih.gov/34462398/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,32054438,"Population-specific, recent positive directional selection suggests adaptation of human male reproductive genes to different environmental conditions.",2020,10.1186/s12862-019-1575-0,https://pubmed.ncbi.nlm.nih.gov/32054438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,31850197,A Diagnostic Panel of DNA Methylation Biomarkers for Lung Adenocarcinoma.,2019,10.3389/fonc.2019.01281,https://pubmed.ncbi.nlm.nih.gov/31850197/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,33187986,A conserved acetylation switch enables pharmacological control of tubby-like protein stability.,2021,10.1074/jbc.ra120.015839,https://pubmed.ncbi.nlm.nih.gov/33187986/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,9096357,"Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases.",1997,10.1073/pnas.94.7.3128,https://pubmed.ncbi.nlm.nih.gov/9096357/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,15738400,Genome-wide transcriptional analysis of flagellar regeneration in Chlamydomonas reinhardtii identifies orthologs of ciliary disease genes.,2005,10.1073/pnas.0408358102,https://pubmed.ncbi.nlm.nih.gov/15738400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,11000483,GFP-tagged expression and immunohistochemical studies to determine the subcellular localization of the tubby gene family members.,2000,10.1016/s0169-328x(00)00164-9,https://pubmed.ncbi.nlm.nih.gov/11000483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,9828123,"Molecular characterization of a novel tubby gene family member, TULP3, in mouse and humans.",1998,10.1006/geno.1998.5567,https://pubmed.ncbi.nlm.nih.gov/9828123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,14708010,Tubby proteins: the plot thickens.,2004,10.1038/nrm1278,https://pubmed.ncbi.nlm.nih.gov/14708010/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,11483369,"Molecular cloning, expression and regulation of the avian tubby-like protein 1 (tulp1) gene.",2001,10.1016/s0378-1119(01)00578-9,https://pubmed.ncbi.nlm.nih.gov/11483369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TULP2,ENSG00000104804,Unsafe,15905330,Identification of cancer/testis-antigen genes by massively parallel signature sequencing.,2005,10.1073/pnas.0502583102,https://pubmed.ncbi.nlm.nih.gov/15905330/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TVP23C,ENSG00000175106,Unsafe,37152992,Transcriptomic insights into adenoid cystic carcinoma via RNA sequencing.,2023,10.3389/fgene.2023.1144945,https://pubmed.ncbi.nlm.nih.gov/37152992/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TVP23C,ENSG00000175106,Unsafe,37463833,Landscape of semi-extractable RNAs across five human cell lines.,2023,10.1093/nar/gkad567,https://pubmed.ncbi.nlm.nih.gov/37463833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TVP23C,ENSG00000175106,Unsafe,32123817,Identification of several plasma proteins whose levels in colorectal cancer patients differ depending on outcome.,2019,10.1096/fba.2019-00062,https://pubmed.ncbi.nlm.nih.gov/32123817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,40091773,"Oxidative stress markers 8-OHdG, Trx-1, and Prx6 are expressed in seminoma and are connected to TXNDC2, 3, and 6 expression levels.",2025,10.14670/hh-18-898,https://pubmed.ncbi.nlm.nih.gov/40091773/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,42677124,Decoding astrocytic tryptophan metabolism in the pathogenesis of epilepsy: evidence from artificial intelligence-driven multi-omics and clinical validation.,2026,10.3389/fnins.2026.1913179,https://pubmed.ncbi.nlm.nih.gov/42677124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,42128968,Mendelian randomization analysis of causal relationships between chondrosarcoma and angiogenesis related genes.,2026,10.1007/s12672-026-04621-0,https://pubmed.ncbi.nlm.nih.gov/42128968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,41280771,Trp101-Mediated Cold Adaptation in &lt;i&gt;Sphingomonas&lt;/i&gt; sp. Thioredoxin: Increased α4-Helix Rigidity with Preserved Overall Flexibility.,2025,10.1021/acsomega.5c07089,https://pubmed.ncbi.nlm.nih.gov/41280771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,34158577,TXNDC2 joint molecular marker is associated with testis pathology and is an accurate predictor of sperm retrieval.,2021,10.1038/s41598-021-92603-3,https://pubmed.ncbi.nlm.nih.gov/34158577/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,33603952,"Testis-Specific Thioredoxins TXNDC2, TXNDC3, and TXNDC6 Are Expressed in Both Testicular and Systemic DLBCL and Correlate with Clinical Disease Presentation.",2021,10.1155/2021/8026941,https://pubmed.ncbi.nlm.nih.gov/33603952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,38463323,"Thr-to-Ala Mutation Leads to a Larger Aromatic Pair and Reduced Packing Density in α1,α3-Helices during Thioredoxin Cold Adaptation.",2024,10.1021/acsomega.3c09806,https://pubmed.ncbi.nlm.nih.gov/38463323/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,36230452,F1 Male Sterility in Cattle-Yak Examined through Changes in Testis Tissue and Transcriptome Profiles.,2022,10.3390/ani12192711,https://pubmed.ncbi.nlm.nih.gov/36230452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,37093439,Improving effects of telmisartan on spermatogenic disorder induced by fractionated low-dose irradiation in mice.,2023,10.1007/s11255-023-03601-5,https://pubmed.ncbi.nlm.nih.gov/37093439/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,35682598,Comprehensive Flow-Cytometric Quality Assessment of Ram Sperm Intended for Gene Banking Using Standard and Novel Fertility Biomarkers.,2022,10.3390/ijms23115920,https://pubmed.ncbi.nlm.nih.gov/35682598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,38318849,The Significance of the Redox Gene in the Prognosis and Therapeutic Response of Glioma.,2024,10.1097/coc.0000000000001086,https://pubmed.ncbi.nlm.nih.gov/38318849/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,34910731,Essential roles of buried phenylalanine in the structural stability of thioredoxin from a psychrophilic Arctic bacterium Sphingomonas sp.,2021,10.1371/journal.pone.0261123,https://pubmed.ncbi.nlm.nih.gov/34910731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,25501236,Molecular characterization of thioredoxin-1 and thioredoxin reductase activity in mud crab Scylla paramamosain.,2014,10.4238/2014.december.4.19,https://pubmed.ncbi.nlm.nih.gov/25501236/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,24728569,Molecular analysis of testis biopsy and semen pellet as complementary methods with histopathological analysis of testis in non-obstructive azoospermia.,2014,10.1007/s10815-014-0220-5,https://pubmed.ncbi.nlm.nih.gov/24728569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,15781233,Absolute mRNA levels and transcriptional regulation of the mouse testis-specific thioredoxins.,2005,10.1016/j.bbrc.2005.02.128,https://pubmed.ncbi.nlm.nih.gov/15781233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,15181017,"Spermatocyte/spermatid-specific thioredoxin-3, a novel Golgi apparatus-associated thioredoxin, is a specific marker of aberrant spermatogenesis.",2004,10.1074/jbc.m404192200,https://pubmed.ncbi.nlm.nih.gov/15181017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,17725311,"[Correlation of testis/sperm specific thioredoxin-1, 2 and 3 with male reproduction].",2007,,https://pubmed.ncbi.nlm.nih.gov/17725311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,12149401,"Cloning, expression and characterization of mouse spermatid specific thioredoxin-1 gene and protein.",2002,10.1093/molehr/8.8.710,https://pubmed.ncbi.nlm.nih.gov/12149401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,11737268,"Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells.",2001,10.1046/j.1365-2443.2001.00484.x,https://pubmed.ncbi.nlm.nih.gov/11737268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,12909633,"Cloning and developmental analysis of murid spermatid-specific thioredoxin-2 (SPTRX-2), a novel sperm fibrous sheath protein and autoantigen.",2003,10.1074/jbc.m305475200,https://pubmed.ncbi.nlm.nih.gov/12909633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
TXNDC2,ENSG00000168454,Unsafe,11399755,"Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa.",2001,10.1074/jbc.m101760200,https://pubmed.ncbi.nlm.nih.gov/11399755/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,42848643,UBE2S promotes gastric cancer progression through RACGAP1 stabilization associated with K292-dependent K63-linked ubiquitination.,2026,10.1080/15384047.2026.2737476,https://pubmed.ncbi.nlm.nih.gov/42848643/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,42032653,UBE2S promotes small cell lung cancer transformation and progression via monitoring metabolic remodeling and cell cycle.,2026,10.1186/s12967-026-08146-6,https://pubmed.ncbi.nlm.nih.gov/42032653/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,42133651,UBE2S emerges as a key driver in an NK cell-based prognostic model for clear cell renal cell carcinoma.,2026,10.1371/journal.pone.0344925,https://pubmed.ncbi.nlm.nih.gov/42133651/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,42669192,"UBE2S Promotes KIRC Progression by Regulating CDC20 Expression and Suppressing FDX1-Mediated Cuproptosis, While Promoting M2 Macrophage Polarization.",2026,10.1002/mc.70171,https://pubmed.ncbi.nlm.nih.gov/42669192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,41427004,"Prognostic Value of UBE2S, HIF-1α, and FOXM1 Expression in Esophageal Squamous Cell Carcinoma.",2025,10.1155/ancp/3557238,https://pubmed.ncbi.nlm.nih.gov/41427004/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,41378026,Ubiquitin-conjugating enzyme E2S serves as a prognostic marker for skin cutaneous melanoma.,2025,10.21037/tcr-2025-620,https://pubmed.ncbi.nlm.nih.gov/41378026/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,41254082,Mechanistic insights into IL-6-mediated NK cell dysfunction in NSCLC via the IRE1α-XBP1s-STAT3-UBE2S axis.,2025,10.1038/s41698-025-01140-z,https://pubmed.ncbi.nlm.nih.gov/41254082/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,41623377,UBE2S and HIF1α expression patterns and stratified analysis reveal prognostic value in esophageal squamous cell carcinoma.,2026,10.7717/peerj.20694,https://pubmed.ncbi.nlm.nih.gov/41623377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,41351058,UBE2S-mediated deubiquitination of GLUT1 via USP10 regulates glucose metabolic reprogramming and immune microenvironment to promote fibrosis in endometriosis.,2025,10.1186/s12967-025-07436-9,https://pubmed.ncbi.nlm.nih.gov/41351058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,41083491,UBE2S inhibits colorectal cancer proliferation by regulating the PI3K/AKT and MAPK/ERK pathways via TRAF6.,2025,10.1038/s41598-025-18637-z,https://pubmed.ncbi.nlm.nih.gov/41083491/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,41391673,"Unraveling the secrets of UBE2S in endometrial cancer: Potential targets for diagnosis, prognostic assessment, and ferroptosis therapy.",2026,10.1016/j.cellsig.2025.112325,https://pubmed.ncbi.nlm.nih.gov/41391673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,41359628,The deubiquitinating enzyme Cezanne stabilizes BRCA1 by counteracting APC/C and Ube2S-dependent Lys11-linked ubiquitination.,2025,10.1371/journal.pbio.3003545,https://pubmed.ncbi.nlm.nih.gov/41359628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,40819747,NSUN2 promotes osteosarcoma metastasis via stabilizing UBE2S mRNA in an m5C-dependent manner.,2025,10.1016/j.cellsig.2025.112065,https://pubmed.ncbi.nlm.nih.gov/40819747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,41609080,Exploring the Molecular Mechanisms and Shared Genetic Characteristics of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma.,2026,10.31083/fbl46992,https://pubmed.ncbi.nlm.nih.gov/41609080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,41751958,FOXM1 Signaling Network Transcriptionally Upregulates Expression of Proteins Involved in Mitotic Progression to Induce High Proliferation and Chromosomal Instability in Androgen Receptor-Low Triple-Negative Breast Cancer.,2026,10.3390/ijms27041823,https://pubmed.ncbi.nlm.nih.gov/41751958/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,39904430,Ubiquitin-conjugating enzyme E2S decreases the sensitivity of glioblastoma cells to temozolomide by upregulating PGAM1 via the interaction with OTUB2.,2025,10.1016/j.ijbiomac.2025.140583,https://pubmed.ncbi.nlm.nih.gov/39904430/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,39807632,"UBE2S, downregulated by miR-152-3p, facilitates prostate cancer progression through the PTEN-mediated AKT/mTOR pathway.",2025,10.1093/hmg/ddaf004,https://pubmed.ncbi.nlm.nih.gov/39807632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,41898804,The Regulation of p53 by Ubiquitination and Implications for Therapeutic Targeting in Colorectal Cancer.,2026,10.3390/genes17030270,https://pubmed.ncbi.nlm.nih.gov/41898804/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,40188527,Ubiquitin-conjugating enzyme E2S (UBE2S) as a prognostic biomarker and regulator of tumorigenesis in osteosarcoma.,2025,10.1016/j.intimp.2025.114545,https://pubmed.ncbi.nlm.nih.gov/40188527/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,38915206,UBE2S promotes glycolysis in hepatocellular carcinoma by enhancing E3 enzyme-independent polyubiquitination of VHL.,2024,10.3350/cmh.2024.0236,https://pubmed.ncbi.nlm.nih.gov/38915206/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,40189665,Construction of ubiquitination-related risk model for predicting prognosis in lung adenocarcinoma.,2025,10.1038/s41598-025-92177-4,https://pubmed.ncbi.nlm.nih.gov/40189665/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,38312603,Diverse roles of UBE2S in cancer and therapy resistance: Biological functions and mechanisms.,2024,10.1016/j.heliyon.2024.e24465,https://pubmed.ncbi.nlm.nih.gov/38312603/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,40029500,Single cell transcriptomic analysis reveals tumor immune infiltration by macrophage cells gene signature in lung adenocarcinoma.,2025,10.1007/s12672-025-01834-7,https://pubmed.ncbi.nlm.nih.gov/40029500/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,35578600,"A Pan-Cancer Analysis of UBE2S in Tumorigenesis, Prognosis, Pathway, Immune Infiltration and Evasion, and Therapy Response from an Immune-Oncology Perspective.",2022,10.1155/2022/3982539,https://pubmed.ncbi.nlm.nih.gov/35578600/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,37422473,UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.,2023,10.1038/s41419-023-05938-2,https://pubmed.ncbi.nlm.nih.gov/37422473/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,37223535,"The landscape of UBE2S in hepatocellular carcinoma: Prognostic significance, immuno-oncology feature and drug response.",2023,10.1016/j.gendis.2022.04.010,https://pubmed.ncbi.nlm.nih.gov/37223535/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,38577593,Prognostic and Immune Landscape Analysis of Ubiquitination-related Genes in Hepatocellular Carcinoma: Based on Bulk and Single-cell RNA Sequencing Data.,2024,10.7150/jca.93425,https://pubmed.ncbi.nlm.nih.gov/38577593/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,37693154,UBE2S targets RPL26 for ubiquitination and degradation to promote non-small cell lung cancer progression via regulating c-Myc.,2023,,https://pubmed.ncbi.nlm.nih.gov/37693154/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2S,ENSG00000108106,Unsafe,37007952,Development and validation of a tumor immune cell infiltration-related gene signature for recurrence prediction by weighted gene co-expression network analysis in prostate cancer.,2023,10.3389/fgene.2023.1067172,https://pubmed.ncbi.nlm.nih.gov/37007952/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,42755793,Type I collagen promotes triple-negative breast cancer progression through a UBE2V1-ACSL5 regulatory axis.,2026,10.3389/fonc.2026.1916886,https://pubmed.ncbi.nlm.nih.gov/42755793/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,42215525,CircRNA-cZFR is upregulated in bladder cancer and promotes tumorigenesis via UBE2V1 regulation.,2026,10.1038/s41598-026-48969-3,https://pubmed.ncbi.nlm.nih.gov/42215525/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,42374413,BRD4-mediated histone H4K12 lactylation drives ovarian cancer progression by activating the Ube2v1-DDX3X ubiquitination axis.,2026,10.1186/s12967-026-08434-1,https://pubmed.ncbi.nlm.nih.gov/42374413/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,41446875,UBE2V1 Promotes Hepatocellular Carcinoma Progression by Forming a Positive Feedback Loop with HIF-1α.,2025,10.34133/research.1041,https://pubmed.ncbi.nlm.nih.gov/41446875/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,41879050,Uev1A counteracts oncogenic &lt;i&gt;Ras&lt;/i&gt; stimuli in both polyploid and diploid cells.,2026,10.7554/elife.107104,https://pubmed.ncbi.nlm.nih.gov/41879050/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,41258590,Genetic screening identifies Ube2v1 as a suppressor of immunoglobulin class switch recombination in CH12F3 cells.,2025,10.1007/s11033-025-11268-7,https://pubmed.ncbi.nlm.nih.gov/41258590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,40394227,UBE2V1 governs aging induced protein aggregation and developmental defects in oocytes and embryos.,2025,10.1038/s42003-025-08214-5,https://pubmed.ncbi.nlm.nih.gov/40394227/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,41232091,Serum exosomal miR-1275 as a potential biomarker for the diagnosis and prognostic assessment of hepatocellular carcinoma.,2025,10.1177/18758592251396221,https://pubmed.ncbi.nlm.nih.gov/41232091/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,39789578,Integrated bioinformatics analysis and experimental validation of exosome-related gene signature in steroid-induced osteonecrosis of the femoral head.,2025,10.1186/s13018-025-05456-1,https://pubmed.ncbi.nlm.nih.gov/39789578/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,37954522,Clinicopathological significance and prognostic implications of Ube2v1 expression in colorectal cancer.,2023,10.3892/mi.2023.119,https://pubmed.ncbi.nlm.nih.gov/37954522/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,34466666,Expression and clinical significance of UBE2V1 in cervical cancer.,2021,10.1016/j.bbrep.2021.101108,https://pubmed.ncbi.nlm.nih.gov/34466666/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,42300294,BMS-CTMC-2025-461Ubiquitin as a Putative Causal Immune Orchestrator in Initial COVID-19 Severity: A Mendelian Randomization and Multi-Omics Study.,2026,10.2174/0115680266458416260529222552,https://pubmed.ncbi.nlm.nih.gov/42300294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,39986592,A novel paracetamol derivative alleviates lipopolysaccharide-induced neuroinflammation.,2025,10.1016/j.ejphar.2025.177409,https://pubmed.ncbi.nlm.nih.gov/39986592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,40609214,Differential expression of lncRNAs and mRNAs in bone marrow-derived mesenchymal stem cells under continuous and intermittent teriparatide treatment.,2025,10.1016/j.biopha.2025.118293,https://pubmed.ncbi.nlm.nih.gov/40609214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,33108402,Leishmania differentiation requires ubiquitin conjugation mediated by a UBC2-UEV1 E2 complex.,2020,10.1371/journal.ppat.1008784,https://pubmed.ncbi.nlm.nih.gov/33108402/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,38795139,Role of Ubiquitin-conjugating enzyme E2 (UBE2) in two immune-mediated inflammatory skin diseases: a mendelian randomization analysis.,2024,10.1007/s00403-024-02976-4,https://pubmed.ncbi.nlm.nih.gov/38795139/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,36121211,Microarray and in silico analysis of DNA repair genes between human testis of patients with nonobstructive azoospermia and normal cells.,2022,10.1002/cbf.3747,https://pubmed.ncbi.nlm.nih.gov/36121211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,39237880,Hsa_circ_0000520 suppresses vasculogenic mimicry formation and metastasis in bladder cancer through Lin28a/PTEN/PI3K signaling.,2024,10.1186/s11658-024-00627-0,https://pubmed.ncbi.nlm.nih.gov/39237880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,37786443,Hypoxia-induced long non-coding RNA LINC00460 promotes p53 mediated proliferation and metastasis of pancreatic cancer by regulating the miR-4689/UBE2V1 axis and sequestering USP10.,2023,10.7150/ijms.87833,https://pubmed.ncbi.nlm.nih.gov/37786443/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,38176925,Bioinformatic Analysis and Experimental Validation of Ubiquitin-Proteasomal System-Related Hub Genes as Novel Biomarkers for Alzheimer's Disease.,2023,10.31083/j.jin2206138,https://pubmed.ncbi.nlm.nih.gov/38176925/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,38935533,FATTY ACID DESATURASE4 enhances plant RNA virus replication and undergoes host vacuolar ATPase-mediated degradation.,2024,10.1093/plphys/kiae350,https://pubmed.ncbi.nlm.nih.gov/38935533/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,35368888,Identify a DNA Damage Repair Gene Signature for Predicting Prognosis and Immunotherapy Response in Cervical Squamous Cell Carcinoma.,2022,10.1155/2022/8736575,https://pubmed.ncbi.nlm.nih.gov/35368888/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,35960109,CircRNA expression profile and potential role of hsa_circ_0040039 in intervertebral disc degeneration.,2022,10.1097/md.0000000000030035,https://pubmed.ncbi.nlm.nih.gov/35960109/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,36362243,Proteomics of Aqueous Humor as a Source of Disease Biomarkers in Retinoblastoma.,2022,10.3390/ijms232113458,https://pubmed.ncbi.nlm.nih.gov/36362243/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,20420830,Recruitment of Uev1B to Hrs-containing endosomes and its effect on endosomal trafficking.,2010,10.1016/j.yexcr.2010.04.017,https://pubmed.ncbi.nlm.nih.gov/20420830/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,29108000,Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1.,2017,10.1371/journal.ppat.1006703,https://pubmed.ncbi.nlm.nih.gov/29108000/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,33298875,Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility.,2020,10.1038/s41421-020-00231-4,https://pubmed.ncbi.nlm.nih.gov/33298875/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,23573234,Gene-expression changes in cerium chloride-induced injury of mouse hippocampus.,2013,10.1371/journal.pone.0060092,https://pubmed.ncbi.nlm.nih.gov/23573234/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,29532025,"Ube2V2 Is a Rosetta Stone Bridging Redox and Ubiquitin Codes, Coordinating DNA Damage Responses.",2018,10.1021/acscentsci.7b00556,https://pubmed.ncbi.nlm.nih.gov/29532025/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,30224375,UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling.,2018,10.1158/0008-5472.can-18-1040,https://pubmed.ncbi.nlm.nih.gov/30224375/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,14764741,In vivo evidence that peptide vaccination can induce HLA-DR-restricted CD4+ T cells reactive to a class I tumor peptide.,2004,10.4049/jimmunol.172.4.2659,https://pubmed.ncbi.nlm.nih.gov/14764741/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,31110484,Transcriptomic Analysis of Mecp2 Mutant Mice Reveals Differentially Expressed Genes and Altered Mechanisms in Both Blood and Brain.,2019,10.3389/fpsyt.2019.00278,https://pubmed.ncbi.nlm.nih.gov/31110484/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,22545106,Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study.,2012,10.1371/journal.pone.0035425,https://pubmed.ncbi.nlm.nih.gov/22545106/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,20613989,Protein-protein interaction antagonists as novel inhibitors of non-canonical polyubiquitylation.,2010,10.1371/journal.pone.0011403,https://pubmed.ncbi.nlm.nih.gov/20613989/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,9705497,The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family.,1998,10.1093/nar/26.17.3908,https://pubmed.ncbi.nlm.nih.gov/9705497/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE2V1,ENSG00000244687,Unsafe,9418904,"Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells.",1998,10.1128/mcb.18.1.576,https://pubmed.ncbi.nlm.nih.gov/9418904/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,42867806,Loss of UBE3C-mediated PIM2 ubiquitination drives Helicobacter pylori-induced gastritis via JAK2/STAT3 activation.,2026,10.1007/s11010-026-05774-w,https://pubmed.ncbi.nlm.nih.gov/42867806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,42476128,Structures of dynamic interactors at native proteasomes by PhIX-MS and cryo-electron microscopy.,2026,10.1016/j.molcel.2026.06.032,https://pubmed.ncbi.nlm.nih.gov/42476128/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,41965876,Endogenous protein tagging coupled with a CRISPR screening approach identifies UBE3C as a potential MYC oncogene regulator.,2026,10.1038/s41598-026-47974-w,https://pubmed.ncbi.nlm.nih.gov/41965876/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,42829916,CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells.,2026,10.1002/advs.78088,https://pubmed.ncbi.nlm.nih.gov/42829916/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,40495659,Melatonin mitigates ovarian aging through regulation of the YTHDF2/m &lt;sup&gt;6&lt;/sup&gt;A/UBE3C axis.,2025,10.3724/abbs.2025090,https://pubmed.ncbi.nlm.nih.gov/40495659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,41398047,SLAP controls mTORC2 integrity via UBE3C-mediated non-degradative mLST8 ubiquitination to suppress colorectal tumorigenesis.,2026,10.1038/s41418-025-01633-1,https://pubmed.ncbi.nlm.nih.gov/41398047/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,40696164,METTL5-mediated m6A modification of UBE3C promotes osteosarcoma progression by suppressing ferroptosis via inducing AHNAK ubiquitination.,2025,10.1007/s10735-025-10495-3,https://pubmed.ncbi.nlm.nih.gov/40696164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,40553397,UBE3C promotes pancreatic ductal adenocarcinoma progression by catalysing p53 ubiquitination.,2025,10.1007/s11033-025-10751-5,https://pubmed.ncbi.nlm.nih.gov/40553397/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,40602747,Identification of UBE3C as an E3 ubiquitin ligase for mutant BRAF.,2025,10.1016/j.lfs.2025.123827,https://pubmed.ncbi.nlm.nih.gov/40602747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,39212385,UBE3C restricts EV-A71 replication by ubiquitination-dependent degradation of 2C.,2024,10.1128/jvi.01335-24,https://pubmed.ncbi.nlm.nih.gov/39212385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,36380488,Novel gene-intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy.,2023,10.1093/brain/awac424,https://pubmed.ncbi.nlm.nih.gov/36380488/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,39990664,SEC61G Facilitates Brain Metastases via Antagonizing PGAM1 Ubiquitination and Immune Microenvironment Remodeling in Non-Small Cell Lung Cancer.,2025,10.7150/ijbs.109187,https://pubmed.ncbi.nlm.nih.gov/39990664/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,40308888,"Exosomal miR-137-3p targets UBE3C to activate STAT3, promoting migration and differentiation into endometrial epithelial cell of human umbilical cord mesenchymal stem cells under hypoxia.",2025,10.4252/wjsc.v17.i4.100359,https://pubmed.ncbi.nlm.nih.gov/40308888/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,38438481,Recurrent UBE3C-LRP5 translocations in head and neck cancer with therapeutic implications.,2024,10.1038/s41698-024-00555-4,https://pubmed.ncbi.nlm.nih.gov/38438481/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,39682999,Effect of Fatty Acids on Backfat Quality in Beijing Black Pigs.,2024,10.3390/foods13233927,https://pubmed.ncbi.nlm.nih.gov/39682999/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,39636856,Temporal control of acute protein aggregate turnover by UBE3C and NRF1-dependent proteasomal pathways.,2024,10.1073/pnas.2417390121,https://pubmed.ncbi.nlm.nih.gov/39636856/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,37173692,LINC00963-FOSB-mediated transcription activation of UBE3C enhances radioresistance of breast cancer cells by inducing ubiquitination-dependent protein degradation of TP73.,2023,10.1186/s12967-023-04153-z,https://pubmed.ncbi.nlm.nih.gov/37173692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,40653069,Agricultural copper pesticide exposure and DNA methylation in Central Valley of California residents with and without Parkinson's disease.,2025,10.1016/j.envres.2025.122335,https://pubmed.ncbi.nlm.nih.gov/40653069/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,38067172,UBE3C Facilitates the ER-Associated and Peripheral Degradation of Misfolded CFTR.,2023,10.3390/cells12232741,https://pubmed.ncbi.nlm.nih.gov/38067172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,35914132,P38α MAPK is a gatekeeper of uterine progesterone responsiveness at peri-implantation via Ube3c-mediated PGR degradation.,2022,10.1073/pnas.2206000119,https://pubmed.ncbi.nlm.nih.gov/35914132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,35840930,"Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway.",2022,10.1186/s12943-022-01607-8,https://pubmed.ncbi.nlm.nih.gov/35840930/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,37760932,UBL3 Interaction with α-Synuclein Is Downregulated by Silencing MGST3.,2023,10.3390/biomedicines11092491,https://pubmed.ncbi.nlm.nih.gov/37760932/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,38125763,Current insights into the oncogenic roles of lncRNA LINC00355.,2023,10.1002/cai2.91,https://pubmed.ncbi.nlm.nih.gov/38125763/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,36343628,Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy.,2023,10.1080/15548627.2022.2139921,https://pubmed.ncbi.nlm.nih.gov/36343628/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,25658088,UBE3C promotes growth and metastasis of renal cell carcinoma via activating Wnt/β-catenin pathway.,2015,10.1371/journal.pone.0115622,https://pubmed.ncbi.nlm.nih.gov/25658088/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,26389696,Liganded ERα Stimulates the E3 Ubiquitin Ligase Activity of UBE3C to Facilitate Cell Proliferation.,2015,10.1210/me.2015-1125,https://pubmed.ncbi.nlm.nih.gov/26389696/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,33182779,"Molecular Evolution, Neurodevelopmental Roles and Clinical Significance of HECT-Type UBE3 E3 Ubiquitin Ligases.",2020,10.3390/cells9112455,https://pubmed.ncbi.nlm.nih.gov/33182779/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,25752577,Assembly and specific recognition of k29- and k33-linked polyubiquitin.,2015,10.1016/j.molcel.2015.01.042,https://pubmed.ncbi.nlm.nih.gov/25752577/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,29782494,Ubiquitin-dependent proteolysis of CXCL7 leads to posterior longitudinal ligament ossification.,2018,10.1371/journal.pone.0196204,https://pubmed.ncbi.nlm.nih.gov/29782494/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,19846067,A genomewide association study of citalopram response in major depressive disorder.,2010,10.1016/j.biopsych.2009.08.029,https://pubmed.ncbi.nlm.nih.gov/19846067/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,12692129,Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase.,2003,10.1074/jbc.m212887200,https://pubmed.ncbi.nlm.nih.gov/12692129/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,11278995,A HECT domain E3 enzyme assembles novel polyubiquitin chains.,2001,10.1074/jbc.m100034200,https://pubmed.ncbi.nlm.nih.gov/11278995/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3C,ENSG00000009335,Unsafe,9575161,Characterization of human hect domain family members and their interaction with UbcH5 and UbcH7.,1998,10.1074/jbc.273.20.12148,https://pubmed.ncbi.nlm.nih.gov/9575161/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3D,ENSG00000118420,Unsafe,40075082,Deficiency of UBE3D in mice leads to severe embryonic abnormalities and disrupts the mRNA of Homeobox genes via CPSF3.,2025,10.1038/s41420-025-02387-y,https://pubmed.ncbi.nlm.nih.gov/40075082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3D,ENSG00000118420,Unsafe,41582361,Ubiquitination-based Classification and a Prognostic Signature Identify the Role of TRIM21 in Sarcoma Progression.,2026,10.2174/0109298673388379251113061745,https://pubmed.ncbi.nlm.nih.gov/41582361/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3D,ENSG00000118420,Unsafe,36519931,UBE3D Regulates mRNA 3'-End Processing and Maintains Adipogenic Potential in 3T3-L1 Cells.,2022,10.1128/mcb.00174-22,https://pubmed.ncbi.nlm.nih.gov/36519931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3D,ENSG00000118420,Unsafe,39032490,Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function.,2024,10.1016/j.molcel.2024.06.017,https://pubmed.ncbi.nlm.nih.gov/39032490/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3D,ENSG00000118420,Unsafe,39199913,Novel Candidate Genes Involved in an Initial Stage of White Striping Development in Broiler Chickens.,2024,10.3390/ani14162379,https://pubmed.ncbi.nlm.nih.gov/39199913/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3D,ENSG00000118420,Unsafe,39308831,Population structure and selective signature of Kirghiz sheep by Illumina Ovine SNP50 BeadChip.,2024,10.7717/peerj.17980,https://pubmed.ncbi.nlm.nih.gov/39308831/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3D,ENSG00000118420,Unsafe,40629317,The related SNPs and genes to body size using GWAS- latent variable modeling in dromedaries.,2025,10.1186/s12864-025-11766-9,https://pubmed.ncbi.nlm.nih.gov/40629317/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3D,ENSG00000118420,Unsafe,36094642,UBE3D Is Involved in Blue Light-Induced Retinal Damage by Regulating Double-Strand Break Repair.,2022,10.1167/iovs.63.10.7,https://pubmed.ncbi.nlm.nih.gov/36094642/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3D,ENSG00000118420,Unsafe,38099500,Active DHEA uptake in the prostate gland correlates with aggressive prostate cancer.,2023,10.1172/jci171199,https://pubmed.ncbi.nlm.nih.gov/38099500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3D,ENSG00000118420,Unsafe,35992060,"Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration, invasion, and self-renewal.",2022,10.1016/j.isci.2022.104804,https://pubmed.ncbi.nlm.nih.gov/35992060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3D,ENSG00000118420,Unsafe,32200270,"ube3d, a New Gene Associated with Age-Related Macular Degeneration, Induces Functional Changes in Both In Vivo and In Vitro Studies.",2020,10.1016/j.omtn.2020.02.010,https://pubmed.ncbi.nlm.nih.gov/32200270/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3D,ENSG00000118420,Unsafe,37106959,Population Genetic Analysis of Six Chinese Indigenous Pig Meta-Populations Based on Geographically Isolated Regions.,2023,10.3390/ani13081396,https://pubmed.ncbi.nlm.nih.gov/37106959/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3D,ENSG00000118420,Unsafe,35873486,Genomic Diversity and Selection Signatures for Weining Cattle on the Border of Yunnan-Guizhou.,2022,10.3389/fgene.2022.848951,https://pubmed.ncbi.nlm.nih.gov/35873486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3D,ENSG00000118420,Unsafe,33050709,Genetic determinants of ammonia-induced acute lung injury in mice.,2021,10.1152/ajplung.00276.2020,https://pubmed.ncbi.nlm.nih.gov/33050709/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3D,ENSG00000118420,Unsafe,29783944,Estimates of genomic heritability and genome-wide association study for fatty acids profile in Santa Inês sheep.,2018,10.1186/s12864-018-4777-8,https://pubmed.ncbi.nlm.nih.gov/29783944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBE3D,ENSG00000118420,Unsafe,26962152,Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease.,2016,10.1093/hmg/ddw069,https://pubmed.ncbi.nlm.nih.gov/26962152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBL4B,ENSG00000186150,Unsafe,36779514,The MAEL expression in mitochondria of human spermatozoa and the association with asthenozoospermia.,2023,10.1111/andr.13408,https://pubmed.ncbi.nlm.nih.gov/36779514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBL4B,ENSG00000186150,Unsafe,40428403,Genetic Determinants of Colonic Diverticulosis-A Systematic Review.,2025,10.3390/genes16050581,https://pubmed.ncbi.nlm.nih.gov/40428403/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBL4B,ENSG00000186150,Unsafe,34249105,The Dispensable Roles of X-Linked Ubl4a and Its Autosomal Counterpart Ubl4b in Spermatogenesis Represent a New Evolutionary Type of X-Derived Retrogenes.,2021,10.3389/fgene.2021.689902,https://pubmed.ncbi.nlm.nih.gov/34249105/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBL4B,ENSG00000186150,Unsafe,19333399,Spermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers.,2009,10.1371/journal.pone.0005064,https://pubmed.ncbi.nlm.nih.gov/19333399/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBL4B,ENSG00000186150,Unsafe,16872915,"Ubl4b, an X-derived retrogene, is specifically expressed in post-meiotic germ cells in mammals.",2007,10.1016/j.modgep.2006.06.002,https://pubmed.ncbi.nlm.nih.gov/16872915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBL4B,ENSG00000186150,Unsafe,29936662,Progression Rate Associated Peripheral Blood Biomarkers of Parkinson's Disease.,2018,10.1007/s12031-018-1102-6,https://pubmed.ncbi.nlm.nih.gov/29936662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBL4B,ENSG00000186150,Unsafe,22139977,Generation of mice with conditional null allele for GdX/Ubl4A.,2012,10.1002/dvg.20832,https://pubmed.ncbi.nlm.nih.gov/22139977/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBXN10,ENSG00000162543,Unsafe,40496915,Case Report: Phenotypic and genetic characterization of a presumptive sporadic hypothalamic hamartoma in a standard Schnauzer dog.,2025,10.3389/fvets.2025.1591863,https://pubmed.ncbi.nlm.nih.gov/40496915/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBXN10,ENSG00000162543,Unsafe,40644891,Biomarker discovery for early breast cancer diagnosis using machine learning on transcriptomic data for biosensor development.,2025,10.1016/j.compbiomed.2025.110584,https://pubmed.ncbi.nlm.nih.gov/40644891/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBXN10,ENSG00000162543,Unsafe,40949454,Development of a prognostic risk model for predicting biochemical recurrence-free survival in patients with prostate cancer based on lysine acetylation.,2025,10.21037/tau-2025-179,https://pubmed.ncbi.nlm.nih.gov/40949454/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBXN10,ENSG00000162543,Unsafe,35034539,LncRNA ubiquitin-binding protein domain protein 10 antisense RNA 1 inhibits colon adenocarcinoma progression via the miR-515-5p/slit guidance ligand 3 axis.,2022,10.1080/21655979.2021.2024396,https://pubmed.ncbi.nlm.nih.gov/35034539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBXN10,ENSG00000162543,Unsafe,38226611,PRADclass: Hybrid Gleason Grade-Informed Computational Strategy Identifies Consensus Biomarker Features Predictive of Aggressive Prostate Adenocarcinoma.,2024,10.1177/15330338231222389,https://pubmed.ncbi.nlm.nih.gov/38226611/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBXN10,ENSG00000162543,Unsafe,37245085,An in-silico Approach for Recognition of Long non-coding RNA-Associated Competing Endogenous RNA Axes in Prostate Cancer.,2024,10.22037/uj.v20i.7650,https://pubmed.ncbi.nlm.nih.gov/37245085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBXN10,ENSG00000162543,Unsafe,35414328,Expression status and prognostic value of autophagy-related lncRNAs in prostate cancer.,2022,10.1080/15384101.2022.2065149,https://pubmed.ncbi.nlm.nih.gov/35414328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBXN10,ENSG00000162543,Unsafe,34926580,5-Methylcytosine RNA Methyltransferases-Related Long Non-coding RNA to Develop and Validate Biochemical Recurrence Signature in Prostate Cancer.,2021,10.3389/fmolb.2021.775304,https://pubmed.ncbi.nlm.nih.gov/34926580/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBXN10,ENSG00000162543,Unsafe,26389662,Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.,2015,10.1038/ncb3238,https://pubmed.ncbi.nlm.nih.gov/26389662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBXN10,ENSG00000162543,Unsafe,32037394,The Cardiac Genome Clinic: implementing genome sequencing in pediatric heart disease.,2020,10.1038/s41436-020-0757-x,https://pubmed.ncbi.nlm.nih.gov/32037394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UBXN10,ENSG00000162543,Unsafe,21156036,DNA methylation in glioblastoma: impact on gene expression and clinical outcome.,2010,10.1186/1471-2164-11-701,https://pubmed.ncbi.nlm.nih.gov/21156036/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,42084407,Characterization of the corticotropin-releasing hormone family in largemouth bass and their expression profiles in response to feeding and acute and chronic heat stress.,2026,10.1111/jfb.70481,https://pubmed.ncbi.nlm.nih.gov/42084407/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,42338588,Multi-omics analysis of kidney renal cell carcinoma in silico with preliminary &lt;i&gt;in vivo&lt;/i&gt; validation.,2026,10.3389/fimmu.2026.1732965,https://pubmed.ncbi.nlm.nih.gov/42338588/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,42617550,CRHR2 activation by urocortins regulates splenic microbiota-immune-brain axis in a single prolonged stress model of post-traumatic stress in male rats.,2026,10.1016/j.npep.2026.102651,https://pubmed.ncbi.nlm.nih.gov/42617550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,41408446,Treadmill training or caloric restriction delays aging-associated increase in urocortin 2-induced hyperthermia in middle-aged male Wistar rats.,2025,10.1038/s41598-025-32585-8,https://pubmed.ncbi.nlm.nih.gov/41408446/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,40275076,Urocortin2 measurement for heart failure assessment.,2025,10.1038/s41598-025-99509-4,https://pubmed.ncbi.nlm.nih.gov/40275076/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,40037626,Suppression of Luteinizing Hormone Secretion in Female Mice by a Urocortin 2-CRHR2 Signaling Pathway.,2025,10.1210/endocr/bqaf042,https://pubmed.ncbi.nlm.nih.gov/40037626/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,40138071,Electroacupuncture Improves the Motor Function in Rats with Spinal Cord Injury by Regulating UCN2-Mediated cAMP-PKA Signaling in the Spinal Cord Microenvironment.,2025,10.1007/s10571-025-01537-1,https://pubmed.ncbi.nlm.nih.gov/40138071/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,40530752,Machine Learning Characterization of Immunometabolism in the Tumor Microenvironment and Immunotherapy Responses in Bladder Cancer.,2025,10.1097/cji.0000000000000568,https://pubmed.ncbi.nlm.nih.gov/40530752/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,41329780,Identification of oxidative stress-responsive genes in recurrent miscarriage and their role in disease pathogenesis.,2025,10.1371/journal.pone.0337362,https://pubmed.ncbi.nlm.nih.gov/41329780/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,42254588,A fusion-based multiomics classification approach for enhanced gene discovery in non-small cell lung cancer.,2026,10.1093/bioadv/vbag131,https://pubmed.ncbi.nlm.nih.gov/42254588/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,37402735,Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity.,2023,10.1038/s41467-023-39597-w,https://pubmed.ncbi.nlm.nih.gov/37402735/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,37860766,Human skin CD141+ dendritic cells regulate cutaneous immunity via the neuropeptide urocortin 2.,2023,10.1016/j.isci.2023.108029,https://pubmed.ncbi.nlm.nih.gov/37860766/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,40934983,"Exploratory safety investigations in normal, freely moving Göttingen Minipigs using telemetry: Pharmacological validation.",2025,10.1016/j.vascn.2025.108395,https://pubmed.ncbi.nlm.nih.gov/40934983/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,39506968,Transcriptomic analysis of embryonic mouse hypothalamic N38 cells exposed to high-energy protons and/or simulated microgravity.,2024,10.1016/j.heliyon.2024.e39533,https://pubmed.ncbi.nlm.nih.gov/39506968/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,37433214,Effects of Urocortin 2 Gene Transfer on Glucose Disposal in Insulin-Resistant db/db Mice on Metformin.,2023,10.1089/hum.2023.052,https://pubmed.ncbi.nlm.nih.gov/37433214/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,39581268,The effects of corticotropin-releasing factor (CRF) and urocortins on the noradrenaline (NA) released from the locus coeruleus (LC).,2024,10.1016/j.peptides.2024.171322,https://pubmed.ncbi.nlm.nih.gov/39581268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,39595978,Single Intranasal Administration of Ucn3 Affects the Development of PTSD Symptoms in an Animal Model.,2024,10.3390/ijms252211908,https://pubmed.ncbi.nlm.nih.gov/39595978/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,40123464,Osmoregulatory contributions of the corticotropin-releasing factor system in the intestine of Atlantic salmon.,2025,10.1242/jeb.250052,https://pubmed.ncbi.nlm.nih.gov/40123464/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,38616821,Role of CRH in colitis and colitis-associated cancer: a combinative result of central and peripheral effects?,2024,10.3389/fendo.2024.1363748,https://pubmed.ncbi.nlm.nih.gov/38616821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,39798539,"The effects of corticotropin-releasing factor (CRF) and urocortins on the serotonin (hydroxytryptamine, 5HT) released from the raphe nuclei (RN).",2025,10.1016/j.npep.2025.102503,https://pubmed.ncbi.nlm.nih.gov/39798539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,39247280,Prediction of clear cell renal cell carcinoma prognosis based on an immunogenomic landscape analysis.,2024,10.1016/j.heliyon.2024.e36156,https://pubmed.ncbi.nlm.nih.gov/39247280/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,31676153,Urocortin 2 Gene Transfer Improves Heart Function in Aged Mice.,2020,10.1016/j.ymthe.2019.10.003,https://pubmed.ncbi.nlm.nih.gov/31676153/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,27699250,One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance.,2016,10.1172/jci.insight.88322,https://pubmed.ncbi.nlm.nih.gov/27699250/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,34724890,Development of a prognostic signature of patients with esophagus adenocarcinoma by using immune-related genes.,2021,10.1186/s12859-021-04456-2,https://pubmed.ncbi.nlm.nih.gov/34724890/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,30062211,Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal.,2018,10.1016/j.jacbts.2017.12.004,https://pubmed.ncbi.nlm.nih.gov/30062211/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,28929494,CRHR2/Ucn2 signaling is a novel regulator of miR-7/YY1/Fas circuitry contributing to reversal of colorectal cancer cell resistance to Fas-mediated apoptosis.,2018,10.1002/ijc.31064,https://pubmed.ncbi.nlm.nih.gov/28929494/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,25760560,Intravenous AAV8 Encoding Urocortin-2 Increases Function of the Failing Heart in Mice.,2015,10.1089/hum.2014.157,https://pubmed.ncbi.nlm.nih.gov/25760560/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,23931341,Intravenous adeno-associated virus serotype 8 encoding urocortin-2 provides sustained augmentation of left ventricular function in mice.,2013,10.1089/hum.2013.088,https://pubmed.ncbi.nlm.nih.gov/23931341/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,26495412,Diminished expression of CRHR2 in human colon cancer promotes tumor growth and EMT via persistent IL-6/Stat3 signaling.,2015,10.1016/j.jcmgh.2015.08.001,https://pubmed.ncbi.nlm.nih.gov/26495412/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UCN2,ENSG00000145040,Unsafe,22339174,"Comparative pharmacokinetics and pharmacodynamics of urocortins 1, 2 and 3 in healthy sheep.",2012,10.1111/j.1476-5381.2012.01904.x,https://pubmed.ncbi.nlm.nih.gov/22339174/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,42783252,"Metabolic Reprogramming Supports Neonicotinoid Resistance in the Brown Planthopper, &lt;i&gt;Nilaparvata lugens&lt;/i&gt;.",2026,10.3390/insects17090884,https://pubmed.ncbi.nlm.nih.gov/42783252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,37983911,Quantitative analysis of the UDP-glucuronosyltransferase transcriptome in human tissues.,2023,10.1002/prp2.1154,https://pubmed.ncbi.nlm.nih.gov/37983911/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,39887940,Structural Insights into the Substrate Recognition of Ginsenoside Glycosyltransferase Pq3-O-UGT2.,2025,10.1002/advs.202413185,https://pubmed.ncbi.nlm.nih.gov/39887940/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,36508673,Selective involvement of UGGT variant: UGGT2 in protecting mouse embryonic fibroblasts from saturated lipid-induced ER stress.,2022,10.1073/pnas.2214957119,https://pubmed.ncbi.nlm.nih.gov/36508673/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,36424908,Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans-chromosomic mouse line expressing human UGT2 enzymes.,2022,10.1002/prp2.1030,https://pubmed.ncbi.nlm.nih.gov/36424908/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,42138572,Integrated Transcriptomic and Enzymatic Analysis Reveals the Detoxification Response of Asian Spongy Gypsy Moth Lymantria dispar asiatica to Chlorantraniliprole.,2026,10.1002/arch.70163,https://pubmed.ncbi.nlm.nih.gov/42138572/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,38184160,"Expression, purification, characterization and crystallization of Panax quinquefolius ginsenoside glycosyltransferase Pq3-O-UGT2.",2024,10.1016/j.pep.2024.106430,https://pubmed.ncbi.nlm.nih.gov/38184160/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,42042053,"Evolutionary Characteristics and Expression Patterns of the &lt;i&gt;UGT&lt;/i&gt; Gene Family in Epimedium from Gansu, China.",2026,10.3390/cimb48040393,https://pubmed.ncbi.nlm.nih.gov/42042053/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,36741721,The Uridine diphosphate (UDP)-glycosyltransferases (UGTs) superfamily: the role in tumor cell metabolism.,2022,10.3389/fonc.2022.1088458,https://pubmed.ncbi.nlm.nih.gov/36741721/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,38585359,Serum biomarkers in patients with drug-resistant epilepsy: a proteomics-based analysis.,2024,10.3389/fneur.2024.1383023,https://pubmed.ncbi.nlm.nih.gov/38585359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,36224499,Rice glycosyltransferase gene UGT2 functions in salt stress tolerance under the regulation of bZIP23 transcription factor.,2023,10.1007/s00299-022-02933-3,https://pubmed.ncbi.nlm.nih.gov/36224499/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,40462234,Unraveling the genetic blueprint of doxorubicin-induced cardiotoxicity through systems genetics approaches.,2025,10.1186/s40959-025-00349-y,https://pubmed.ncbi.nlm.nih.gov/40462234/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,38272446,Rescue of secretion of rare-disease-associated misfolded mutant glycoproteins in UGGT1 knock-out mammalian cells.,2024,10.1111/tra.12927,https://pubmed.ncbi.nlm.nih.gov/38272446/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,39457450,Validating Disease Associations of Drug-Metabolizing Enzymes through Genome-Wide Association Study Data Analysis.,2024,10.3390/genes15101326,https://pubmed.ncbi.nlm.nih.gov/39457450/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,38909075,Fitness effects of synthetic and natural diet preservatives on the edible insect Bombyx mori.,2024,10.1038/s41538-024-00284-9,https://pubmed.ncbi.nlm.nih.gov/38909075/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,39826345,Coding and non-coding transcripts modulated by transparent and blue PET micro-nanoplastics in Arabidopsis thaliana.,2025,10.1016/j.plaphy.2024.109409,https://pubmed.ncbi.nlm.nih.gov/39826345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,35806479,Complete Reaction Phenotyping of Propranolol and 4-Hydroxypropranolol with the 19 Enzymes of the Human UGT1 and UGT2 Families.,2022,10.3390/ijms23137476,https://pubmed.ncbi.nlm.nih.gov/35806479/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,33320095,Quantitative glycoproteomics reveals cellular substrate selectivity of the ER protein quality control sensors UGGT1 and UGGT2.,2020,10.7554/elife.63997,https://pubmed.ncbi.nlm.nih.gov/33320095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,38292011,Biochemical and in silico characterization of glycosyltransferases from red sweet cherry (Prunus avium L.) reveals their broad specificity toward phenolic substrates.,2024,10.1016/j.fochms.2023.100193,https://pubmed.ncbi.nlm.nih.gov/38292011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,31359729,[Mechanism of Cinnamomi Ramulus improving rat model of intrahepatic cholestasis induced by ANIT by regulating FXR pathway].,2019,10.19540/j.cnki.cjcmm.20190321.402,https://pubmed.ncbi.nlm.nih.gov/31359729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,35731022,Engineering of triterpene metabolism and overexpression of the lignin biosynthesis gene PAL promotes ginsenoside Rg3 accumulation in ginseng plant chassis.,2022,10.1111/jipb.13315,https://pubmed.ncbi.nlm.nih.gov/35731022/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,36634840,De novo biosynthesis of carminic acid in Saccharomyces cerevisiae.,2023,10.1016/j.ymben.2023.01.005,https://pubmed.ncbi.nlm.nih.gov/36634840/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,30379829,The evolution of UDP-glycosyl/glucuronosyltransferase 1E (UGT1E) genes in bird lineages is linked to feeding habits but UGT2 genes is not.,2018,10.1371/journal.pone.0205266,https://pubmed.ncbi.nlm.nih.gov/30379829/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,35534264,[Toxicity mechanism of Rhododendri Mollis Flos: based on serum metabolomics and network toxicology].,2022,10.19540/j.cnki.cjcmm.20211223.702,https://pubmed.ncbi.nlm.nih.gov/35534264/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,31257199,[Chromatin architectural protein CTCF regulates gene expression of the UGT1 cluster].,2019,10.16288/j.yczz.19-072,https://pubmed.ncbi.nlm.nih.gov/31257199/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,30373036,New insights into the metabolism and toxicity of bisphenol A on marine fish under long-term exposure.,2018,10.1016/j.envpol.2018.07.048,https://pubmed.ncbi.nlm.nih.gov/30373036/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,35634928,Convergent copy number increase of genes associated with freshwater colonization in fishes.,2022,10.1098/rstb.2020.0509,https://pubmed.ncbi.nlm.nih.gov/35634928/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,36744215,Inhibitory activity of Enhydra fluctuans Lour. on calcium oxalate crystallisation through in silico and in vitro studies.,2022,10.3389/fphar.2022.982419,https://pubmed.ncbi.nlm.nih.gov/36744215/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,28496260,"Overexpression of a cytochrome P450 and a UDP-glycosyltransferase is associated with imidacloprid resistance in the Colorado potato beetle, Leptinotarsa decemlineata.",2017,10.1038/s41598-017-01961-4,https://pubmed.ncbi.nlm.nih.gov/28496260/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,26354949,Xenobiotic Metabolism in Mice Lacking the UDP-Glucuronosyltransferase 2 Family.,2015,10.1124/dmd.115.065482,https://pubmed.ncbi.nlm.nih.gov/26354949/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,30718425,Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.,2019,10.1073/pnas.1808255116,https://pubmed.ncbi.nlm.nih.gov/30718425/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,20161780,Cloning and comparative analyses of the zebrafish Ugt repertoire reveal its evolutionary diversity.,2010,10.1371/journal.pone.0009144,https://pubmed.ncbi.nlm.nih.gov/20161780/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UGGT2,ENSG00000102595,Unsafe,10694380,Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity.,2000,10.1021/bi9916473,https://pubmed.ncbi.nlm.nih.gov/10694380/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,42008532,Upregulation of CD1d and ULBP3 on B cells from healthy donors and chronic lymphocytic leukaemia patients does not prime them for killing by γδ T cells.,2026,10.1371/journal.pone.0346684,https://pubmed.ncbi.nlm.nih.gov/42008532/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,41346557,Can Serum UL16 Binding Protein 3 Tell Us More about Tinea Capitis?,2025,10.4103/ijt.ijt_104_24,https://pubmed.ncbi.nlm.nih.gov/41346557/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,41565766,Proteomic profiling of single extracellular vesicles as a promising new approach for the diagnosis and treatment modality of advanced ovarian cancer.,2026,10.1038/s41698-026-01271-x,https://pubmed.ncbi.nlm.nih.gov/41565766/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,41366520,Loss of EHMT2 enhances NK cell-driven anti-tumor immunity through TGF-β1 suppression.,2026,10.1038/s44321-025-00357-6,https://pubmed.ncbi.nlm.nih.gov/41366520/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,38780505,Unveiling the role of the KLF4/Lnc18q22.2/ULBP3 axis in the tumorigenesis and immune escape of hepatocellular carcinoma under hypoxic condition.,2024,10.1111/jcmm.18411,https://pubmed.ncbi.nlm.nih.gov/38780505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,37664624,LncRNA TYMSOS facilitates breast cancer metastasis and immune escape through downregulating ULBP3.,2023,10.1016/j.isci.2023.107556,https://pubmed.ncbi.nlm.nih.gov/37664624/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,39963517,The Identification of FN1 as an Early Diagnostic Marker for Recurrent Abortion by Single-Exosome Profiling.,2025,10.2147/ijgm.s487632,https://pubmed.ncbi.nlm.nih.gov/39963517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,39492940,UL16‑binding protein 1 is a significant prognostic and diagnostic marker for breast cancer.,2025,10.3892/ol.2024.14761,https://pubmed.ncbi.nlm.nih.gov/39492940/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,38410511,Elevated levels of cell-free NKG2D-ligands modulate NKG2D surface expression and compromise NK cell function in severe COVID-19 disease.,2024,10.3389/fimmu.2024.1273942,https://pubmed.ncbi.nlm.nih.gov/38410511/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,36741391,Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients.,2022,10.3389/fimmu.2022.1097117,https://pubmed.ncbi.nlm.nih.gov/36741391/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,36210637,A signature based on NKG2D ligands to predict the recurrence of hepatocellular carcinoma after radical resection.,2023,10.1002/cam4.5318,https://pubmed.ncbi.nlm.nih.gov/36210637/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,38953028,"The HHV-6B U20 glycoprotein binds ULBP1, masking it from recognition by NKG2D and interfering with natural killer cell activation.",2024,10.3389/fimmu.2024.1363156,https://pubmed.ncbi.nlm.nih.gov/38953028/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,35936986,The MICA-NKG2D axis in clear cell renal cell carcinoma bolsters MICA as target in immuno-oncology.,2022,10.1080/2162402x.2022.2104991,https://pubmed.ncbi.nlm.nih.gov/35936986/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,33194048,Down-regulation of UL16-binding protein 3 mediated by interferon-gamma impairs immune killing in nasopharyngeal carcinoma.,2020,,https://pubmed.ncbi.nlm.nih.gov/33194048/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,37389656,CLPTM1L is a GPI-anchoring pathway component targeted by HCMV.,2023,10.1083/jcb.202207104,https://pubmed.ncbi.nlm.nih.gov/37389656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,33779082,Clinical Impact of Natural Killer Group 2D Receptor Expression and That of Its Ligand in Ovarian Carcinomas: A Retrospective Study.,2021,10.3349/ymj.2021.62.4.288,https://pubmed.ncbi.nlm.nih.gov/33779082/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,31292299,Arming oHSV with ULBP3 drives abscopal immunity in lymphocyte-depleted glioblastoma.,2019,10.1172/jci.insight.128217,https://pubmed.ncbi.nlm.nih.gov/31292299/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,33909599,Investigation and verification of the clinical significance and perspective of natural killer group 2 member D ligands in colon adenocarcinoma.,2021,10.18632/aging.202935,https://pubmed.ncbi.nlm.nih.gov/33909599/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,39579618,"B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies.",2024,10.1016/j.ebiom.2024.105459,https://pubmed.ncbi.nlm.nih.gov/39579618/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,35740068,HO-1 Limits the Efficacy of Vemurafenib/PLX4032 in BRAFV600E Mutated Melanoma Cells Adapted to Physiological Normoxia or Hypoxia.,2022,10.3390/antiox11061171,https://pubmed.ncbi.nlm.nih.gov/35740068/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,34721381,The HHV-6A Proteins U20 and U21 Target NKG2D Ligands to Escape Immune Recognition.,2021,10.3389/fimmu.2021.714799,https://pubmed.ncbi.nlm.nih.gov/34721381/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,27116977,IDH mutant gliomas escape natural killer cell immune surveillance by downregulation of NKG2D ligand expression.,2016,10.1093/neuonc/now061,https://pubmed.ncbi.nlm.nih.gov/27116977/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,25138242,The regulatory effect of UL-16 binding protein-3 expression on the cytotoxicity of NK cells in cancer patients.,2014,10.1038/srep06138,https://pubmed.ncbi.nlm.nih.gov/25138242/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULBP3,ENSG00000131019,Unsafe,32698530,Human Metapneumovirus Escapes NK Cell Recognition through the Downregulation of Stress-Induced Ligands for NKG2D.,2020,10.3390/v12070781,https://pubmed.ncbi.nlm.nih.gov/32698530/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,42818585,"Cuproptosis-associated genes &lt;i&gt;DLD&lt;/i&gt;, &lt;i&gt;ULK2&lt;/i&gt;, &lt;i&gt;CCL8&lt;/i&gt;, and &lt;i&gt;CCS&lt;/i&gt; link metabolic and immunological dysfunction in Parkinson's disease: a multi-omics study.",2026,10.3389/fimmu.2026.1813166,https://pubmed.ncbi.nlm.nih.gov/42818585/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,42911720,Discovery and Optimization of Isoform Selective ULK1 Degraders to Enhance Antitumor Activity in KRAS-Mutant Cancer.,2026,10.1021/acs.jmedchem.6c01340,https://pubmed.ncbi.nlm.nih.gov/42911720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,41719166,ULK2 suppresses glycolysis to attenuate cisplatin resistance in ovarian cancer organoid via c-Jun phosphorylation.,2026,10.1177/00368504261421695,https://pubmed.ncbi.nlm.nih.gov/41719166/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,42884135,Integrative Phosphoproteomic Characterization of ULK1 Phosphosites Reveals Co-Regulatory Networks in Autophagy and Metabolic Adaptation.,2026,10.3390/ijms27198892,https://pubmed.ncbi.nlm.nih.gov/42884135/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,41550068,&lt;i&gt;ATG&lt;/i&gt; gene duplication in vertebrates: evolutionary divergence and its functional implications.,2026,10.1080/15548627.2026.2618126,https://pubmed.ncbi.nlm.nih.gov/41550068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,42278237,miRNA-Mediated Signaling Networks in Non-Small Cell Lung Cancer: Linking Tumor Progression to Sarcopenia.,2026,10.3390/ijms27114703,https://pubmed.ncbi.nlm.nih.gov/42278237/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,40336101,T-lymphocytes suppression by CD14&lt;sup&gt;+&lt;/sup&gt; monocytes with high expression of ULK2 in patients with multiple myeloma.,2025,10.1186/s12967-025-06516-0,https://pubmed.ncbi.nlm.nih.gov/40336101/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,42094695,Genome-wide association study of myopia progression in Chinese adolescents and application of polygenic risk score prediction.,2026,10.3389/fchem.2026.1778732,https://pubmed.ncbi.nlm.nih.gov/42094695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,41469454,In silico identification of bilobetin and ginsenoside as dual CK2 and ULK2 inhibitors targeting triple-negative breast cancer.,2025,10.1038/s41598-025-33464-y,https://pubmed.ncbi.nlm.nih.gov/41469454/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,40696241,ULK2 promotes migration and invasion of colorectal cancer cells via MCT4-mediated lactate export.,2025,10.1007/s12032-025-02931-x,https://pubmed.ncbi.nlm.nih.gov/40696241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,40664084,Novel insights into the ULK2-FIP200-AMPK-mediated regulation of autophagy and BCR::ABL degradation in chronic myeloid leukemia.,2025,10.1016/j.bbrc.2025.152343,https://pubmed.ncbi.nlm.nih.gov/40664084/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,41689999,Identifying novel biomarkers for systemic lupus erythematosus associated with macrophage activation syndrome.,2026,10.1016/j.biopha.2026.119101,https://pubmed.ncbi.nlm.nih.gov/41689999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,40951946,Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures.,2025,10.1002/alz.70681,https://pubmed.ncbi.nlm.nih.gov/40951946/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,41475172,Transcriptomic and metabolomic insights into lipid metabolism genes underlying meat quality differences between yellow-feathered and white-feathered broilers in China.,2026,10.1016/j.psj.2025.106334,https://pubmed.ncbi.nlm.nih.gov/41475172/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,41958884,Early modulation of autophagy-associated markers in murine adenomyosis and selective persistence in human stromal lesions.,2026,10.3389/fendo.2026.1750026,https://pubmed.ncbi.nlm.nih.gov/41958884/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,38952983,ULK2 suppresses ovarian cancer cell migration and invasion by elevating IGFBP3.,2024,10.7717/peerj.17628,https://pubmed.ncbi.nlm.nih.gov/38952983/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,39348350,"Autophagy-associated biomarkers ULK2, UVRAG, and miRNAs miR-21, miR-126, and miR-374: Prognostic significance in glioma patients.",2024,10.1371/journal.pone.0311308,https://pubmed.ncbi.nlm.nih.gov/39348350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,40319799,ULK2 deficiency stratifies autophagy-driven molecular subtypes and exacerbates trophoblasts apoptosis in preeclampsia.,2025,10.1016/j.placenta.2025.04.015,https://pubmed.ncbi.nlm.nih.gov/40319799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,41255881,Umbilical cord mesenchymal stem cell-derived exosomes promote wound healing and skin regeneration via the regulation of inflammation and angiogenesis.,2025,10.3389/fbioe.2025.1641709,https://pubmed.ncbi.nlm.nih.gov/41255881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,42603538,Exploring ULK family in human cancer: insights into mechanisms and therapeutic potential.,2026,10.1016/j.bioorg.2026.110352,https://pubmed.ncbi.nlm.nih.gov/42603538/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,41674365,Synthesis and Characterization of ULK1/2 Kinase Inhibitors That Inhibit Autophagy and Upregulate Expression of Major Histocompatibility Complex I for the Treatment of Non-Small Cell Lung Cancer.,2026,10.1021/acschembio.5c00711,https://pubmed.ncbi.nlm.nih.gov/41674365/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,38929191,"Screening and Mechanism Study of Three Antagonistic Drugs, Oxysophoridine, Rutin, and Phellodendrine, against Zearalenone-Induced Reproductive Toxicity in Ovine Oocytes.",2024,10.3390/antiox13060752,https://pubmed.ncbi.nlm.nih.gov/38929191/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,41229266,Pharmacogenetic markers of PEG-asparaginase toxicity in Brazilian pediatric ALL: insights from a multicenter prospective cohort study.,2025,10.1080/14622416.2025.2572961,https://pubmed.ncbi.nlm.nih.gov/41229266/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,41017714,Genome-Wide Protein Interaction Analysis in Parasitic Gyrodactylus Flatworms-Fish Hosts System and Drug Target Identification.,2025,10.1002/advs.202514618,https://pubmed.ncbi.nlm.nih.gov/41017714/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,39528529,Bioinformatics analysis and identification of underlying biomarkers potentially linking allergic rhinitis and autophagy.,2024,10.1038/s41598-024-78375-6,https://pubmed.ncbi.nlm.nih.gov/39528529/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,39822999,Synergistic machine learning models utilizing ferroptosis-related genes for improved neuroblastoma outcome prediction.,2024,10.21037/tp-24-323,https://pubmed.ncbi.nlm.nih.gov/39822999/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,41596065,Itaconic Acid Activates Lysosomal Biogenesis and Autophagy Flux and Mitigates High-Fat Diet-Induced Liver Lipid Accumulation in Largemouth Bass (Micropterus salmoides).,2025,10.3390/antiox15010006,https://pubmed.ncbi.nlm.nih.gov/41596065/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,40664895,Developing a machine-learning model to enable treatment selection for neoadjuvant chemotherapy for esophageal cancer.,2025,10.1038/s41598-025-11252-y,https://pubmed.ncbi.nlm.nih.gov/40664895/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,39277994,"Nano-alumina induced developmental and neurobehavioral toxicity in the early life stage of zebrafish, associated with mTOR.",2024,10.1016/j.aquatox.2024.107086,https://pubmed.ncbi.nlm.nih.gov/39277994/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,39145053,Identification of a ferroptosis-related gene signature for the prognosis of pediatric neuroblastoma.,2024,10.21037/tcr-24-269,https://pubmed.ncbi.nlm.nih.gov/39145053/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,34895031,"Immunosurveillance, interferon, and autophagic networking in cancer: the PRKCI-ULK2 paradigm.",2022,10.1080/15548627.2021.1991192,https://pubmed.ncbi.nlm.nih.gov/34895031/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,36387235,Analysis of exosomal competing endogenous RNA network response to paclitaxel treatment reveals key genes in advanced gastric cancer.,2022,10.3389/fonc.2022.1027748,https://pubmed.ncbi.nlm.nih.gov/36387235/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK2,ENSG00000083290,Unsafe,34560002,PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.,2021,10.1016/j.molcel.2021.08.039,https://pubmed.ncbi.nlm.nih.gov/34560002/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,41813586,ULK4 and CDKN2A polymorphisms influence the risk of developing monoclonal gammopathy of undetermined significance.,2026,10.1002/ijc.70427,https://pubmed.ncbi.nlm.nih.gov/41813586/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,40464465,Applications and Possible Mechanisms of ULK4 in Brain: Implications for Neuropsychiatric Disorders.,2025,10.31083/jin31350,https://pubmed.ncbi.nlm.nih.gov/40464465/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,40171800,Phosphorylation-induced SUMOylation promotes Ulk4 condensation at the ciliary tip to transduce Hedgehog signal.,2025,10.1242/jcs.263695,https://pubmed.ncbi.nlm.nih.gov/40171800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,39734234,Disentangling the genetic overlap between ischemic stroke and obesity.,2024,10.1186/s13098-024-01555-x,https://pubmed.ncbi.nlm.nih.gov/39734234/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,42603538,Exploring ULK family in human cancer: insights into mechanisms and therapeutic potential.,2026,10.1016/j.bioorg.2026.110352,https://pubmed.ncbi.nlm.nih.gov/42603538/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,39765701,Identifying Significant SNPs of the Total Number of Piglets Born and Their Relationship with Leg Bumps in Pigs.,2024,10.3390/biology13121034,https://pubmed.ncbi.nlm.nih.gov/39765701/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,38096226,Ulk4 promotes Shh signaling by regulating Stk36 ciliary localization and Gli2 phosphorylation.,2023,10.7554/elife.88637,https://pubmed.ncbi.nlm.nih.gov/38096226/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,39185807,Association of Unc-51-like Kinase 4 (&lt;i&gt;ULK4&lt;/i&gt;) with the reactivity of the extended reward system in response to conditioned stimuli.,2024,10.1080/15622975.2024.2393381,https://pubmed.ncbi.nlm.nih.gov/39185807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,40244254,Single-Nucleotide Polymorphisms Related to Multiple Myeloma Risk: A Systematic Review and Meta-Analysis.,2025,10.3390/ijms26073369,https://pubmed.ncbi.nlm.nih.gov/40244254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,39945255,Prediction of the Prognosis and Treatment Responses Based on the Characteristics of Disulfidptosis-Related Genes in Patients with Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma,2026,10.2174/0118715303374396250129111340,https://pubmed.ncbi.nlm.nih.gov/39945255/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,37584603,The putative protein kinase Stk36 is essential for ciliogenesis and CSF flow by associating with Ulk4.,2023,10.1096/fj.202300481r,https://pubmed.ncbi.nlm.nih.gov/37584603/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,35522199,Deletion of Schizophrenia Susceptibility Gene Ulk4 Leads to Abnormal Cognitive Behaviors via Akt-GSK-3 Signaling Pathway in Mice.,2022,10.1093/schbul/sbac040,https://pubmed.ncbi.nlm.nih.gov/35522199/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,35493088,ULK4 in Neurodevelopmental and Neuropsychiatric Disorders.,2022,10.3389/fcell.2022.873706,https://pubmed.ncbi.nlm.nih.gov/35493088/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,42218382,Integrated environmental and genomic analysis reveals the drivers and genetic mechanisms of agro-climatic adaptation in geese.,2026,10.1186/s12864-026-12991-6,https://pubmed.ncbi.nlm.nih.gov/42218382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,41398767,Systematic druggable genome-wide mendelian randomization identifies therapeutic targets for childhood asthma.,2025,10.1097/md.0000000000046718,https://pubmed.ncbi.nlm.nih.gov/41398767/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,36989043,ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum.,2023,10.1091/mbc.e22-06-0222,https://pubmed.ncbi.nlm.nih.gov/36989043/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,40313396,Prenatal opioid exposure alters pain perception and increases long-term health risks in infants with neonatal opioid withdrawal syndrome.,2025,10.3389/fpain.2025.1497801,https://pubmed.ncbi.nlm.nih.gov/40313396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,34235142,"Ulk4, a Newly Discovered Susceptibility Gene for Schizophrenia, Regulates Corticogenesis in Mice.",2021,10.3389/fcell.2021.645368,https://pubmed.ncbi.nlm.nih.gov/34235142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,36118886,Association of genetic variants in ULK4 with the age of first onset of type B aortic dissection.,2022,10.3389/fgene.2022.956866,https://pubmed.ncbi.nlm.nih.gov/36118886/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,35083612,Schizophrenia predisposition gene Unc-51-like kinase 4 for the improvement of cerebral ischemia/reperfusion injury.,2022,10.1007/s11033-021-07108-z,https://pubmed.ncbi.nlm.nih.gov/35083612/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,37239846,Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization.,2023,10.3390/ijms24108500,https://pubmed.ncbi.nlm.nih.gov/37239846/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,29391390,Ulk4 regulates GABAergic signaling and anxiety-related behavior.,2018,10.1038/s41398-017-0091-5,https://pubmed.ncbi.nlm.nih.gov/29391390/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,37020999,Using multi-tissue transcriptome-wide association study to identify candidate susceptibility genes for respiratory infectious diseases.,2023,10.3389/fgene.2023.1164274,https://pubmed.ncbi.nlm.nih.gov/37020999/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,35433698,The Two-Faced Role of Autophagy in Endometrial Cancer.,2022,10.3389/fcell.2022.839416,https://pubmed.ncbi.nlm.nih.gov/35433698/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,34537014,KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases.,2021,10.1186/s12859-021-04358-3,https://pubmed.ncbi.nlm.nih.gov/34537014/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,26956052,Survival kinase genes present prognostic significance in glioblastoma.,2016,10.18632/oncotarget.7917,https://pubmed.ncbi.nlm.nih.gov/26956052/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,22120009,Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.,2011,10.1038/ng.993,https://pubmed.ncbi.nlm.nih.gov/22120009/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,27587788,A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci.,2016,10.1158/1055-9965.epi-15-1193,https://pubmed.ncbi.nlm.nih.gov/27587788/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,32401642,Autophagy in the physiological endometrium and cancer.,2021,10.1080/15548627.2020.1752548,https://pubmed.ncbi.nlm.nih.gov/32401642/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,25249183,Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.,2015,10.1093/hmg/ddu478,https://pubmed.ncbi.nlm.nih.gov/25249183/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,23972371,Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.,2013,10.1016/j.ajhg.2013.07.010,https://pubmed.ncbi.nlm.nih.gov/23972371/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ULK4,ENSG00000168038,Unsafe,24284070,Recurrent deletions of ULK4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility.,2014,10.1242/jcs.137604,https://pubmed.ncbi.nlm.nih.gov/24284070/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,42321946,Mitochondrial proteases maintain cellular protein homeostasis and tissue integrity.,2026,10.1186/s13578-026-01612-0,https://pubmed.ncbi.nlm.nih.gov/42321946/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,40551644,[Effect of acupuncture on intracerebral mitochondrial function in mice with cerebral hemorrhage].,2025,10.13702/j.1000-0607.20240186,https://pubmed.ncbi.nlm.nih.gov/40551644/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,40806426,The Efficiency of the Krebs Cycle and the Respiratory Chain in Physiologically and Prematurely Aging Bees (&lt;i&gt;Apis mellifera&lt;/i&gt;).,2025,10.3390/ijms26157294,https://pubmed.ncbi.nlm.nih.gov/40806426/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,40565507,The Association Between Dexmedetomidine and Bradycardia: An Analysis of FDA Adverse Event Reporting System (FAERS) Data and Transcriptomic Profiles.,2025,10.3390/genes16060615,https://pubmed.ncbi.nlm.nih.gov/40565507/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,41325391,Integrated single-cell RNA-seq and bulk RNA-seq analysis to investigate key adipogenesis genes in adipose-derived stem cells.,2025,10.1371/journal.pone.0335152,https://pubmed.ncbi.nlm.nih.gov/41325391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,37884186,Uqcr11 alleviates oxidative stress and apoptosis after traumatic brain injury.,2023,10.1016/j.expneurol.2023.114582,https://pubmed.ncbi.nlm.nih.gov/37884186/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,40496861,Exploring the role of mitochondrial metabolism and immune infiltration in myocardial infarction: novel insights from bioinformatics and experimental validation.,2025,10.3389/fimmu.2025.1543584,https://pubmed.ncbi.nlm.nih.gov/40496861/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,38459019,N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration.,2024,10.1038/s41467-024-46458-7,https://pubmed.ncbi.nlm.nih.gov/38459019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,39633257,Gene ontology defines pre-post- hatch energy dynamics in the complexus muscle of broiler chickens.,2024,10.1186/s12864-024-11103-6,https://pubmed.ncbi.nlm.nih.gov/39633257/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,39347483,Using Bioinformatics and Machine Learning to Predict the Genetic Characteristics of Ferroptosis-Cuproptosis-Related Genes Associated with Sleep Deprivation.,2024,10.2147/nss.s473022,https://pubmed.ncbi.nlm.nih.gov/39347483/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,36307865,The immunometabolic landscape of the bone marrow microenvironment in acute myeloid leukemia.,2022,10.1186/s40164-022-00332-8,https://pubmed.ncbi.nlm.nih.gov/36307865/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,38065351,Comparative studies on the chemical composition and pharmacological effects of vinegar-processed antler glue modified from Lei Gong Pao Zhi Lun and traditional water-processed antler glue.,2024,10.1016/j.jep.2023.117508,https://pubmed.ncbi.nlm.nih.gov/38065351/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,38181234,Association of abnormal NDUFB2 and UQCRH expression with venous thromboembolism in patients with liver cirrhosis.,2024,10.1097/md.0000000000036868,https://pubmed.ncbi.nlm.nih.gov/38181234/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,33940051,Association between structural brain features and gene expression by weighted gene co-expression network analysis in conversion from MCI to AD.,2021,10.1016/j.bbr.2021.113330,https://pubmed.ncbi.nlm.nih.gov/33940051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,39341452,Integrated proteomic and glycoproteomic analysis reveals heterogeneity and molecular signatures of brain metastases from lung adenocarcinomas.,2024,10.1016/j.canlet.2024.217262,https://pubmed.ncbi.nlm.nih.gov/39341452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,38901783,Role of oxidative phosphorylation in the antidepressant effects of arketamine via the vagus nerve-dependent spleen-brain axis.,2024,10.1016/j.nbd.2024.106573,https://pubmed.ncbi.nlm.nih.gov/38901783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,36617259,Signatures of selection in indigenous Chinese cattle genomes reveal adaptive genes and genetic variations to cold climate.,2023,10.1093/jas/skad006,https://pubmed.ncbi.nlm.nih.gov/36617259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,37035824,Multi-transcriptomics reveals RLMF axis-mediated signaling molecules associated with bovine feed efficiency.,2023,10.3389/fvets.2023.1090517,https://pubmed.ncbi.nlm.nih.gov/37035824/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,39455924,Transcriptomic analysis reveals differentially expressed genes associated with meat quality in Chinese Dagu chicken and AA+ broiler roosters.,2024,10.1186/s12864-024-10927-6,https://pubmed.ncbi.nlm.nih.gov/39455924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,37894583,"Effects of Microplastic (MP) Exposure at Environmentally Relevant Doses on the Structure, Function, and Transcriptome of the Kidney in Mice.",2023,10.3390/molecules28207104,https://pubmed.ncbi.nlm.nih.gov/37894583/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,31795990,Identification of recurrence marker associated with immune infiltration in prostate cancer with radical resection and build prognostic nomogram.,2019,10.1186/s12885-019-6391-9,https://pubmed.ncbi.nlm.nih.gov/31795990/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,32339879,Mechanism of PM2.5-induced human bronchial epithelial cell toxicity in central China.,2020,10.1016/j.jhazmat.2020.122747,https://pubmed.ncbi.nlm.nih.gov/32339879/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,33138038,Transcriptomic and Proteomic Analysis Reveals Mechanisms of Patulin-Induced Cell Toxicity in Human Embryonic Kidney Cells.,2020,10.3390/toxins12110681,https://pubmed.ncbi.nlm.nih.gov/33138038/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UQCR11,ENSG00000127540,Unsafe,35244775,Transcriptomic and ultrastructural evidence indicate that anti-HMGB1 antibodies rescue organic dust-induced mitochondrial dysfunction.,2022,10.1007/s00441-022-03602-3,https://pubmed.ncbi.nlm.nih.gov/35244775/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,41751772,Nonsense Mutation in &lt;i&gt;USH2A&lt;/i&gt; Exon-13 Activates the Innate Immune Response in Müller Glial Cells.,2026,10.3390/ijms27041636,https://pubmed.ncbi.nlm.nih.gov/41751772/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,42253508,Study on the Mechanism of Hearing Loss Induced by USH2A Gene Knockout.,2026,10.1155/humu/8451291,https://pubmed.ncbi.nlm.nih.gov/42253508/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,42923505,Usher Syndrome Type 2A and Epileptic Encephalopathy with Spike-Wave Activation in Sleep: A Coincidental Dual Diagnosis? Case Report. ,2026,10.1159/msy/adrag009,https://pubmed.ncbi.nlm.nih.gov/42923505/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,41182029,USH2A-Mutated Human Retinal Organoids Model Rod-Cone Dystrophy.,2025,10.1167/iovs.66.14.2,https://pubmed.ncbi.nlm.nih.gov/41182029/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,42565060,Rare Case of Esophageal Squamous Cell Carcinoma in an Adolescent with Multiple Congenital Anomalies and Homozygous USH2A Mutation.,2026,10.4103/jiaps.jiaps_404_25,https://pubmed.ncbi.nlm.nih.gov/42565060/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,42775014,Deep Learning for Diagnosis of Choroideremia and &lt;i&gt;USH2A&lt;/i&gt;-Associated Rod-Cone Dystrophy Using Macular OCT Volumes.,2026,10.1016/j.xops.2026.101378,https://pubmed.ncbi.nlm.nih.gov/42775014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,42710431,Generation of isogenic gene-corrected cell lines from a USH2A-RP patient-derived iPS cell line.,2026,10.1016/j.scr.2026.104094,https://pubmed.ncbi.nlm.nih.gov/42710431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,40970667,Exon Skipping Therapy Restores Ciliary Function in USH2A-Related Retinal Degeneration.,2025,10.1167/iovs.66.12.46,https://pubmed.ncbi.nlm.nih.gov/40970667/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,40994011,"AAV-mediated exon skipping therapy for Usher syndrome, type 2A.",2026,10.1016/j.ymthe.2025.09.038,https://pubmed.ncbi.nlm.nih.gov/40994011/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,41729786,From Sound to Stability: Lessons Learned From the CRUSH Study on Hearing Loss Progression and Vestibular Phenotype in Usher Syndrome Type 2A.,2026,10.1097/mao.0000000000004851,https://pubmed.ncbi.nlm.nih.gov/41729786/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,42866676,Peripheral Vascular Alterations in &lt;i&gt;USH2A&lt;/i&gt;-Retinitis Pigmentosa and Relationship with Macular Involvement: A Cross-Sectional Study.,2026,10.1016/j.xops.2026.101396,https://pubmed.ncbi.nlm.nih.gov/42866676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,40037841,Deciphering the largest disease-associated transcript isoforms in the human neural retina with advanced long-read sequencing approaches.,2025,10.1101/gr.280060.124,https://pubmed.ncbi.nlm.nih.gov/40037841/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,41569027,Modulation of Aerobic Glycolysis Genes During the Progression of Retinitis Pigmentosa.,2026,10.1167/iovs.67.1.49,https://pubmed.ncbi.nlm.nih.gov/41569027/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,41376777,Erratum: Genome Editing in Patient iPSCs Corrects the Most Prevalent &lt;i&gt;USH2A&lt;/i&gt; Mutations and Reveals Intriguing Mutant mRNA Expression Profiles.,2025,10.1016/j.omtm.2025.101645,https://pubmed.ncbi.nlm.nih.gov/41376777/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,42181665,Cystoid Macular Edema in Retinitis Pigmentosa: Pathophysiologic Insight Using Swept-Source OCT and Angiography.,2026,10.1016/j.xops.2026.101193,https://pubmed.ncbi.nlm.nih.gov/42181665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,40677926,Identification of Novel &lt;i&gt;USH2A&lt;/i&gt; Mutations in a Consanguineous Chinese Family With Usher Syndrome.,2025,10.1155/humu/6391770,https://pubmed.ncbi.nlm.nih.gov/40677926/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,39922978,Comparison of CRISPR-Cas13b RNA base editing approaches for USH2A-associated inherited retinal degeneration.,2025,10.1038/s42003-025-07557-3,https://pubmed.ncbi.nlm.nih.gov/39922978/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,40225234,Optic Nerve Coloboma in a Child With Compound Heterozygous USH2A Variants.,2025,10.1155/crig/4667935,https://pubmed.ncbi.nlm.nih.gov/40225234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,41804064,Somatic mosaicism of a novel USH2A variant in Usher syndrome.,2026,10.1080/13816810.2026.2628874,https://pubmed.ncbi.nlm.nih.gov/41804064/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,40624766,An &lt;i&gt;USH2A&lt;/i&gt; variant leading to isolated maculopathy: a novel phenotype.,2025,10.1080/13816810.2025.2528043,https://pubmed.ncbi.nlm.nih.gov/40624766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,40731809,Retinitis Pigmentosa: From Genetic Insights to Innovative Therapeutic Approaches-A Literature Review.,2025,10.3390/medicina61071179,https://pubmed.ncbi.nlm.nih.gov/40731809/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,39620688,Taxane-induced retinal toxicity in a pathogenic USH2A variant carrier.,2024,10.4103/ijo.ijo_914_24,https://pubmed.ncbi.nlm.nih.gov/39620688/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,40877827,"Inherited retinal diseases in Kentucky: diagnostic yield, gene variants, and novel mutations in a U.S. population.",2025,10.1186/s12920-025-02186-5,https://pubmed.ncbi.nlm.nih.gov/40877827/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,40869487,Genetic Therapies for Retinitis Pigmentosa: Current Breakthroughs and Future Directions.,2025,10.3390/jcm14165661,https://pubmed.ncbi.nlm.nih.gov/40869487/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,39620689,Authors' Response: The disastrous triple hit-taxane-induced retinal toxicity in a patient with breast cancer and a pathogenic USH2A variant.,2024,10.4103/ijo.ijo_2079_24,https://pubmed.ncbi.nlm.nih.gov/39620689/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,42627399,Gene therapy clinical trials for inherited eye diseases: The pediatric perspective.,2026,10.1177/11206721261478166,https://pubmed.ncbi.nlm.nih.gov/42627399/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,41552664,Anatomy- versus Sensitivity-Based Loci Preselection in Detecting USH2A-Retinopathy Microperimetric Progression.,2026,10.1016/j.xops.2025.101018,https://pubmed.ncbi.nlm.nih.gov/41552664/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,40423621,Functional Vision Assessment Over 4 Years in USH2A Using the Veteran Affairs Low-Vision Visual Functioning Questionnaire.,2025,10.1167/iovs.66.5.39,https://pubmed.ncbi.nlm.nih.gov/40423621/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,39103200,Long-term natural history of ellipsoid zone width in USH2A-retinopathy.,2025,10.1136/bjo-2024-325323,https://pubmed.ncbi.nlm.nih.gov/39103200/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,40235854,Single-guide RNA Cas9 and enhanced-deletion Cas9 rescue a recurrent &lt;i&gt;USH2A&lt;/i&gt;-related splicing defect.,2025,10.1016/j.omtn.2025.102523,https://pubmed.ncbi.nlm.nih.gov/40235854/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,39811264,"Visual Acuity, Full-field Stimulus Thresholds, and Electroretinography for 4 Years in The Rate of Progression of USH2A-related Retinal Degeneration (RUSH2A) Study.",2025,10.1016/j.xops.2024.100648,https://pubmed.ncbi.nlm.nih.gov/39811264/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,40324556,Natural History of Microperimetry and Optical Coherence Tomography in USH2A-Retinopathy: A Structure-Function Association Study.,2025,10.1016/j.ajo.2025.04.034,https://pubmed.ncbi.nlm.nih.gov/40324556/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,39881543,Systematic empirical evaluation of individual base editing targets: Validating therapeutic targets in USH2A and comparison of methods.,2025,10.1016/j.ymthe.2025.01.042,https://pubmed.ncbi.nlm.nih.gov/39881543/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,39382872,Endpoints and Design for Clinical Trials in USH2A-Related Retinal Degeneration: Results and Recommendations From the RUSH2A Natural History Study.,2024,10.1167/tvst.13.10.15,https://pubmed.ncbi.nlm.nih.gov/39382872/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,37813209,The effects of ush2a gene knockout on vesicle transport in photoreceptors.,2024,10.1016/j.gene.2023.147885,https://pubmed.ncbi.nlm.nih.gov/37813209/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,15015129,Identification of 51 novel exons of the Usher syndrome type 2A (USH2A) gene that encode multiple conserved functional domains and that are mutated in patients with Usher syndrome type II.,2004,10.1086/383096,https://pubmed.ncbi.nlm.nih.gov/15015129/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,12433396,Usherin expression is highly conserved in mouse and human tissues.,2002,10.1016/s0378-5955(02)00635-4,https://pubmed.ncbi.nlm.nih.gov/12433396/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,11788194,Localization and expression of usherin: a novel basement membrane protein defective in people with Usher's syndrome type IIa.,2002,10.1016/s0378-5955(01)00344-6,https://pubmed.ncbi.nlm.nih.gov/11788194/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USH2A,ENSG00000042781,Unsafe,9624053,Mutation of a gene encoding a protein with extracellular matrix motifs in Usher syndrome type IIa.,1998,10.1126/science.280.5370.1753,https://pubmed.ncbi.nlm.nih.gov/9624053/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,42564607,Ubiquitin-specific protease 25: a new regulator for cardiovascular and cerebrovascular diseases.,2026,10.3389/fcell.2026.1802539,https://pubmed.ncbi.nlm.nih.gov/42564607/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,42803147,USP25 stabilises GLI1 through K48-linked deubiquitination within a reciprocal regulatory circuit in osteoarthritis models.,2026,10.1002/ctm2.70851,https://pubmed.ncbi.nlm.nih.gov/42803147/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,42875598,USP25 augments XIAP-mediated signaling to safeguard intestinal homeostasis.,2026,10.1038/s41418-026-01885-5,https://pubmed.ncbi.nlm.nih.gov/42875598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,41692245,USP25 deficiency suppresses diet-induced obesity via ubiquitination and degradation of PARP1 and Elovl3 downregulation.,2026,10.1016/j.jlr.2026.101002,https://pubmed.ncbi.nlm.nih.gov/41692245/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,42792250,Nifuroxazide Pretreatment Protects Against Acute CdCl&lt;sub&gt;2&lt;/sub&gt; Exposure-Induced Toxicity via Modulating the USP21/AIM2 Inflammasome Axis.,2026,10.3390/antiox15091211,https://pubmed.ncbi.nlm.nih.gov/42792250/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,41882191,USP25 aggravates liver cancer development and impairs chemosensitivity by limiting LATS1 activation.,2026,10.1038/s44319-026-00749-w,https://pubmed.ncbi.nlm.nih.gov/41882191/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,42298713,Combining Transarterial Chemoembolisation With Reduced Deubiquitinase Activity Reduces Hepatocellular Carcinoma Progression.,2026,10.1111/jcmm.71209,https://pubmed.ncbi.nlm.nih.gov/42298713/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,42373595,TRMT1-mediated tRNA m&lt;sup&gt;2&lt;/sup&gt;&lt;sub&gt;2&lt;/sub&gt;G modification drives Osimertinib resistance via the ATXN3/USP25 axis in lung adenocarcinoma.,2026,10.1038/s41419-026-09039-8,https://pubmed.ncbi.nlm.nih.gov/42373595/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,42441110,"Disrupting the tumor-associated TNKS-USP25 protein-protein interface in cancer: structural basis, druggability, and therapeutic opportunities.",2026,10.1039/d6ra01334a,https://pubmed.ncbi.nlm.nih.gov/42441110/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,41771990,The role and regulatory mechanism of USP25 in pancreatic microcirculatory disturbance in severe acute pancreatitis.,2026,10.1038/s41598-026-39295-9,https://pubmed.ncbi.nlm.nih.gov/41771990/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,42409806,The deubiquitinase USP25 contributes to stemness and malignant progression of breast cancer by stabilizing C1ql4.,2026,10.1038/s41598-026-49272-x,https://pubmed.ncbi.nlm.nih.gov/42409806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,41918783,A prognostic nomogram for colorectal cancer based on ubiquitin-specific protease 21 expression: a retrospective cohort study.,2026,10.3389/fmolb.2026.1764916,https://pubmed.ncbi.nlm.nih.gov/41918783/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,42168156,USP21 functions as an oncogenic regulator of the Mdm2-p53 axis in colorectal cancer.,2026,10.1038/s41420-026-03170-3,https://pubmed.ncbi.nlm.nih.gov/42168156/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,42838151,USF1 promotes growth and glycolysis in acute myeloid leukemia cells.,2026,10.1016/j.bbadis.2026.168497,https://pubmed.ncbi.nlm.nih.gov/42838151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,41096992,&lt;i&gt;Usp21&lt;/i&gt; Knockout Causes Abnormal Lipid Metabolism in Mouse and Its Polymorphism Correlates with Hypercholesterolemia in Outpatients.,2025,10.3390/ijms26199727,https://pubmed.ncbi.nlm.nih.gov/41096992/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,41861519,USP25 regulates atherosclerosis by restricting RIPK1-mediated inflammatory responses.,2026,10.1016/j.ebiom.2026.106213,https://pubmed.ncbi.nlm.nih.gov/41861519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,41326342,USP25 attenuates the immunosuppressive tumor microenvironment via the deubiquitination of TAB2 in head and neck squamous cell carcinoma.,2025,10.1038/s41420-025-02883-1,https://pubmed.ncbi.nlm.nih.gov/41326342/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,41499392,USP25 inhibition ameliorates Parkinson's disease by restoring mitophagy.,2026,10.1073/pnas.2516471123,https://pubmed.ncbi.nlm.nih.gov/41499392/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,41321637,USP25 deubiquitinates cytosolic METTL3 to impede glioma proliferation via an m6A-independent pathway.,2025,10.1016/j.isci.2025.113918,https://pubmed.ncbi.nlm.nih.gov/41321637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,42412560,ATR senses stiff extracellular matrix to promote epithelial-to-mesenchymal transition and immune suppression.,2026,10.1172/jci192285,https://pubmed.ncbi.nlm.nih.gov/42412560/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,42091690,USP21 drives immune evasion in colorectal cancer via deubiquitination and stabilization of β-catenin.,2026,10.1038/s41423-026-01419-6,https://pubmed.ncbi.nlm.nih.gov/42091690/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,41729829,Ophiopogonin D Reduced Ferroptosis of Skin Epithelial Cells to Thermal Injury by USP25/ TAB2.,2026,10.1177/15347346251409003,https://pubmed.ncbi.nlm.nih.gov/41729829/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,41637985,USP21-mediated SMARCB1 stabilization under hypoxia may influence tumor progression and immune response in HCC.,2026,10.1016/j.bbrc.2026.153383,https://pubmed.ncbi.nlm.nih.gov/41637985/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,41921404,USP25 in atherosclerosis: a new kid on the block.,2026,10.1016/j.ebiom.2026.106243,https://pubmed.ncbi.nlm.nih.gov/41921404/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,40465099,Identification and validation of a thirteen-gene signature based on ubiquitin related genes in cervical cancer.,2025,10.1007/s12672-025-02459-6,https://pubmed.ncbi.nlm.nih.gov/40465099/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,42017948,Structure Merging Approach Leads to New Dual Potent and Selective USP25/USP28 Inhibitors.,2026,10.1021/acs.jmedchem.5c03045,https://pubmed.ncbi.nlm.nih.gov/42017948/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,40629473,USP21-EGFR-Lyn axis drives NSCLC progression and therapeutic potential of USP21 inhibition.,2025,10.1186/s40364-025-00806-x,https://pubmed.ncbi.nlm.nih.gov/40629473/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,38875478,Heterozygous variants in USP25 cause genetic generalized epilepsy.,2024,10.1093/brain/awae191,https://pubmed.ncbi.nlm.nih.gov/38875478/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,11597335,Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25.,2001,10.1186/gb-2001-2-10-research0043,https://pubmed.ncbi.nlm.nih.gov/11597335/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP25,ENSG00000155313,Unsafe,10644437,"USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2.",1999,10.1006/geno.1999.6025,https://pubmed.ncbi.nlm.nih.gov/10644437/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,42671015,Interactions Between E3 Ubiquitin Ligases and Deubiquitinases in AKT Regulation: Implications in Skeletal Muscle Homeostasis.,2026,10.1002/cbf.70297,https://pubmed.ncbi.nlm.nih.gov/42671015/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,42414261,ACSL3 inhibits ferroptosis in gastric cancer through the activation of unfolded protein response following endoplasmic reticulum stress.,2026,10.1038/s41419-026-09068-3,https://pubmed.ncbi.nlm.nih.gov/42414261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,42337222,USP37 facilitates hepatocellular carcinoma progression by deubiquitinating RAF1 and activating ERK1/2 signaling.,2026,10.1007/s10142-026-01931-y,https://pubmed.ncbi.nlm.nih.gov/42337222/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,41980094,CHK2-USP37 axis stabilizes FOXO4 to sustain senescence and evade apoptosis.,2026,10.1073/pnas.2526252123,https://pubmed.ncbi.nlm.nih.gov/41980094/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,41408466,Identification of Raptor and GLI1 as USP37 substrates highlight its context-specific function in medulloblastoma cells.,2026,10.1038/s41388-025-03651-2,https://pubmed.ncbi.nlm.nih.gov/41408466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,40926837,An integrative pan-cancer analysis of USP37 and functional validation in pancreatic cancer.,2025,10.3389/fcell.2025.1659747,https://pubmed.ncbi.nlm.nih.gov/40926837/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,40458725,"The CENPN/STAT3/USP37 signaling axis promotes invasion, migration and metastasis in nasopharyngeal carcinoma.",2025,10.3389/fonc.2025.1536574,https://pubmed.ncbi.nlm.nih.gov/40458725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,40080254,USP37 as a novel regulator of NRF2 protein stability and chemoresistance in HCC.,2025,10.1007/s12672-025-01913-9,https://pubmed.ncbi.nlm.nih.gov/40080254/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,40038378,USP37-stabilized SALL4 promotes the keloid formation by PI3K/AKT pathway.,2025,10.1038/s41598-025-91776-5,https://pubmed.ncbi.nlm.nih.gov/40038378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,41633365,The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus.,2026,10.1016/j.cels.2025.101488,https://pubmed.ncbi.nlm.nih.gov/41633365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,41399373,Deubiquitomic and bioinformatic analyses in cisplatin-treated lung cancer cells.,2026,10.7150/ijms.120464,https://pubmed.ncbi.nlm.nih.gov/41399373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,40379725,USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination.,2025,10.1038/s41467-025-59770-7,https://pubmed.ncbi.nlm.nih.gov/40379725/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,40486858,CDK1-mediated phosphorylation of USP37 regulates SND1 stability and promotes oncogenesis in colorectal cancer.,2025,10.1016/j.apsb.2025.02.014,https://pubmed.ncbi.nlm.nih.gov/40486858/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,40533495,USP37 prevents premature disassembly of stressed replisomes by TRAIP.,2025,10.1038/s41467-025-60139-z,https://pubmed.ncbi.nlm.nih.gov/40533495/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,40548939,USP37 counteracts HLTF to protect damaged replication forks and promote survival of BRCA1-deficient cells and PARP inhibitor resistance.,2025,10.1093/nar/gkaf544,https://pubmed.ncbi.nlm.nih.gov/40548939/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,39655951,Deubiquitinase USP37 enhances the anti-HIV-2/SIV ability of the host restriction factor SAMHD1.,2025,10.1128/jvi.01858-24,https://pubmed.ncbi.nlm.nih.gov/39655951/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,39722070,USP37 promotes diffuse large B-cell lymphoma progression by deubiquitinating and stabilizing c-myc.,2024,10.1007/s10735-024-10323-0,https://pubmed.ncbi.nlm.nih.gov/39722070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,37424824,USP37 promotes angiogenesis and metastasis in colorectal cancer by facilitating β-catenin stability.,2023,,https://pubmed.ncbi.nlm.nih.gov/37424824/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,37955924,Synergistic anticancer effect by targeting CDK2 and EGFR-ERK signaling.,2024,10.1083/jcb.202203005,https://pubmed.ncbi.nlm.nih.gov/37955924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,38352690,"Ubiquitin specific peptidase (USP37) mediated effects in microscaffold-encapsulated cells: a comprehensive study on growth, proliferation and EMT.",2024,10.1039/d3ra08786g,https://pubmed.ncbi.nlm.nih.gov/38352690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,36405275,Emerging potential of ubiquitin-specific proteases and ubiquitin-specific proteases inhibitors in breast cancer treatment.,2022,10.12998/wjcc.v10.i32.11690,https://pubmed.ncbi.nlm.nih.gov/36405275/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP37,ENSG00000135913,Unsafe,14715245,Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.,2004,10.1016/j.bbrc.2003.12.050,https://pubmed.ncbi.nlm.nih.gov/14715245/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,42636941,CPT1A-driven USP44 K543 succinylation promotes esophageal squamous cell carcinoma progression via inhibiting CDK5RAP3 K166 deubiquitination.,2026,10.1016/j.ijbiomac.2026.154173,https://pubmed.ncbi.nlm.nih.gov/42636941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,42080060,"Clinical Relevance of USP44 Expression and DNA Methylation Status in Breast Cancer Cell Lines, Tumor Tissues, and Circulating Tumor DNA.",2026,10.2147/bctt.s599533,https://pubmed.ncbi.nlm.nih.gov/42080060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,42183175,USP44 Stabilizes MAOB via Deubiquitination to Inhibit Cisplatin Resistance in Lung Adenocarcinoma.,2026,10.1155/ijog/7433804,https://pubmed.ncbi.nlm.nih.gov/42183175/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,41250203,Hypermethylated USP44 deubiquitinates SENP2: a critical mechanism in esophageal cancer progression and a new target for intervention.,2025,10.1186/s13148-025-01958-1,https://pubmed.ncbi.nlm.nih.gov/41250203/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,41299552,Protective effects of mouse bone marrow mesenchymal stem cell-derived extracellular vesicles on radiation-induced epididymal cells damage via USP44/RBM14 axis.,2025,10.1186/s13287-025-04782-9,https://pubmed.ncbi.nlm.nih.gov/41299552/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,40619273,USP44 promotes chemotherapeutic drug resistance of triple negative breast cancer through EZH2 protein stability.,2025,10.1080/15384047.2025.2529652,https://pubmed.ncbi.nlm.nih.gov/40619273/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,41333036,Chronic Exposure to Cigarette Smoke Induces Pyroptosis in Pulmonary Epithelial Cells via EGR1/USP44/TRAF6 Axis in COPD.,2025,10.2147/jir.s546865,https://pubmed.ncbi.nlm.nih.gov/41333036/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,40824171,USP44 Regulates Chemoresistance Induced by ROS and the MAPK/NF-κB Pathway Through the Stabilization of ITGB4 in Gastric Cancer.,2025,10.1096/fj.202501369r,https://pubmed.ncbi.nlm.nih.gov/40824171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,40922130,"USP44, ZNF454, and GPRC5B ctDNA Methylation Markers in Breast Cancer: Limited Clinical Relevance for Disease Monitoring and Tumor Characteristics.",2026,10.1111/ajco.70015,https://pubmed.ncbi.nlm.nih.gov/40922130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,39722007,USP44 regulates HEXIM1 stability to inhibit tumorigenesis and metastasis of oral squamous cell carcinoma.,2024,10.1186/s13062-024-00573-z,https://pubmed.ncbi.nlm.nih.gov/39722007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,39215663,The deubiquitinase USP44 enhances cisplatin chemosensitivity through stabilizing STUB1 to promote LRPPRC degradation in neuroblastoma.,2025,10.1093/neuonc/noae175,https://pubmed.ncbi.nlm.nih.gov/39215663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,41626181,Identify and validate a novel ubiquitination-related biomarker for thyroid cancer prognosis and immunotherapy.,2025,10.3389/fonc.2025.1542784,https://pubmed.ncbi.nlm.nih.gov/41626181/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,38500512,"Mechanism of miR-98-5p in gastric cancer cell proliferation, migration, and invasion through the USP44/CTCFL axis.",2024,10.1093/toxres/tfae040,https://pubmed.ncbi.nlm.nih.gov/38500512/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,39767807,Proximity Proteomics Reveals USP44 Forms a Complex with BRCA2 in Neuroblastoma Cells and Is Required to Prevent Chromosome Breakage.,2024,10.3390/biomedicines12122901,https://pubmed.ncbi.nlm.nih.gov/39767807/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,39430240,USP44 inactivation accelerates the progression of thyroid cancer by inducing ubiquitylation and degradation of p21.,2024,10.7150/ijbs.99817,https://pubmed.ncbi.nlm.nih.gov/39430240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,38775808,USP44 Overexpression Drives a MYC-Like Gene Expression Program in Neuroblastoma through Epigenetic Reprogramming.,2024,10.1158/1541-7786.mcr-23-0454,https://pubmed.ncbi.nlm.nih.gov/38775808/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,39659944,Effect of subcutaneous adipose tissue-associated CSRP2 on the progression of prostate cancer via the WDR5/USP44 pathway.,2024,10.62347/ahqt5920,https://pubmed.ncbi.nlm.nih.gov/39659944/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,38097536,The deubiquitinating enzyme USP44 suppresses hepatocellular carcinoma progression by inhibiting Hedgehog signaling and PDL1 expression.,2023,10.1038/s41419-023-06358-y,https://pubmed.ncbi.nlm.nih.gov/38097536/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,37791390,CBX7 reprograms metabolic flux to protect against meningioma progression by modulating the USP44/c-MYC/LDHA axis.,2024,10.1093/jmcb/mjad057,https://pubmed.ncbi.nlm.nih.gov/37791390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,39819761,Discovery of Methylated DNA Biomarkers for Potential Nonendoscopic Detection of Barrett's Esophagus and Esophageal Adenocarcinoma.,2025,10.14309/ajg.0000000000003323,https://pubmed.ncbi.nlm.nih.gov/39819761/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,37816258,RNA-binding protein NOVA1 promotes acute T-lymphocyte leukemia progression by stabilizing USP44 mRNA.,2024,10.1139/bcb-2023-0092,https://pubmed.ncbi.nlm.nih.gov/37816258/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,36483601,USP44 accelerates the growth of T-cell acute lymphoblastic leukemia through interacting with WDR5 and repressing its ubiquitination.,2022,10.7150/ijms.74535,https://pubmed.ncbi.nlm.nih.gov/36483601/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,37204480,Integrated network findings reveal ubiquitin-specific protease 44 overexpression suppresses tumorigenicity of liver cancer.,2023,10.18632/aging.204733,https://pubmed.ncbi.nlm.nih.gov/37204480/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,36380875,"Insight into the physiological and pathological roles of USP44, a potential tumor target (Review).",2022,10.3892/ol.2022.13575,https://pubmed.ncbi.nlm.nih.gov/36380875/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,35079021,USP44 regulates irradiation-induced DNA double-strand break repair and suppresses tumorigenesis in nasopharyngeal carcinoma.,2022,10.1038/s41467-022-28158-2,https://pubmed.ncbi.nlm.nih.gov/35079021/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,32644293,The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation.,2020,10.15252/embr.202050308,https://pubmed.ncbi.nlm.nih.gov/32644293/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,34572834,USP44 Promoter Methylation in Plasma Cell-Free DNA in Prostate Cancer.,2021,10.3390/cancers13184607,https://pubmed.ncbi.nlm.nih.gov/34572834/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,37234870,Diagnostic rate of germline pathogenic variants in pancreatic ductal adenocarcinoma patients using whole genome sequencing.,2023,10.3389/fgene.2023.1172365,https://pubmed.ncbi.nlm.nih.gov/37234870/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,28544703,High ubiquitin-specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer.,2017,10.1002/cam4.1090,https://pubmed.ncbi.nlm.nih.gov/28544703/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,28938551,Overexpression of ubiquitin specific proteases 44 promotes the malignancy of glioma by stabilizing tumor-promoter securin.,2017,10.18632/oncotarget.16447,https://pubmed.ncbi.nlm.nih.gov/28938551/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,21853124,Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia.,2011,10.1371/journal.pone.0023389,https://pubmed.ncbi.nlm.nih.gov/21853124/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP44,ENSG00000136014,Unsafe,14715245,Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.,2004,10.1016/j.bbrc.2003.12.050,https://pubmed.ncbi.nlm.nih.gov/14715245/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,42123680,Ubiquitin-Specific Protease 49 Interacts with Bax to Modulate Apoptosis.,2026,10.3390/ijms27094102,https://pubmed.ncbi.nlm.nih.gov/42123680/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,42728347,Circular RNA MCM3 recruits USP49 to stabilize PTBP1 and promote cisplatin resistance in cervical squamous cell carcinoma.,2026,10.1038/s41388-026-03988-2,https://pubmed.ncbi.nlm.nih.gov/42728347/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,41519241,USP49 regulates lipid metabolism in hepatocellular carcinoma by stabilizing RACK1 to promote tumor proliferation and migration.,2026,10.1016/j.bbamcr.2026.120107,https://pubmed.ncbi.nlm.nih.gov/41519241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,41443044,USP49 promotes the malignancy of triple-negative breast cancer cells by regulating PKMYT1 ubiquitination and stability.,2026,10.1016/j.bbrc.2025.153163,https://pubmed.ncbi.nlm.nih.gov/41443044/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,41035649,FBXO2 promotes hepatocellular carcinoma progression and sorafenib resistance by targeting USP49 for proteasomal degradation.,2025,10.3389/fimmu.2025.1660034,https://pubmed.ncbi.nlm.nih.gov/41035649/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,41349242,Vitexin targets USP49-GRPR deubiquitination axis in medullary thyroid carcinoma therapy.,2026,10.1016/j.bbadis.2025.168128,https://pubmed.ncbi.nlm.nih.gov/41349242/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,41399373,Deubiquitomic and bioinformatic analyses in cisplatin-treated lung cancer cells.,2026,10.7150/ijms.120464,https://pubmed.ncbi.nlm.nih.gov/41399373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,40460957,USP49 undergoes liquid-liquid phase separation and stabilizes RPA70 to induce radioresistance through homologous recombination repair in esophageal squamous cell carcinoma.,2025,10.1016/j.ijbiomac.2025.144834,https://pubmed.ncbi.nlm.nih.gov/40460957/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,39497328,IGF2BP3-dependent N6-methyladenosine modification of USP49 promotes carboplatin resistance in retinoblastoma by enhancing autophagy via regulating the stabilization of SIRT1.,2024,10.1002/kjm2.12902,https://pubmed.ncbi.nlm.nih.gov/39497328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,40234906,Cold atmospheric plasma drives USP49/HDAC3 axis mediated ferroptosis as a novel therapeutic strategy in endometrial cancer via reinforcing lactylation dependent p53 expression.,2025,10.1186/s12967-025-06449-8,https://pubmed.ncbi.nlm.nih.gov/40234906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,41041437,Deubiquitinating Enzymes in Osteoarthritis: From Mechanisms to Therapeutic.,2025,10.52965/001c.144733,https://pubmed.ncbi.nlm.nih.gov/41041437/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,39234990,Ubiquitin-specific peptidase 49 promotes adenocarcinoma of the esophagogastric junction malignant progression via activating SHCBP1-β-catenin-GPX4 axis.,2025,10.1093/carcin/bgae060,https://pubmed.ncbi.nlm.nih.gov/39234990/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,39568464,miR-361-3p overexpression promotes apoptosis and inflammation by regulating the USP49/IκBα/NF-κB pathway to aggravate sepsis-induced myocardial injury.,2024,10.1093/toxres/tfae190,https://pubmed.ncbi.nlm.nih.gov/39568464/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,40818063,Inhibition of UBE2N promotes the clearance of mutant HTT (huntingtin) in HD knock-in mice.,2025,10.1080/15548627.2025.2549109,https://pubmed.ncbi.nlm.nih.gov/40818063/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,41605053,ResiDUBs: A deubiquitinating enzyme-based prognostic model identifies UBXN1 driving sorafenib resistance in liver cancer.,2026,10.1016/j.intimp.2026.116290,https://pubmed.ncbi.nlm.nih.gov/41605053/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,37991085,"CDK5R1, GSE1, HSPG2 and WDFY3 as indirect epigenetic-sensitive genes in atrial fibrillation.",2024,10.1111/eci.14135,https://pubmed.ncbi.nlm.nih.gov/37991085/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,35072515,USP49-Mediated Histone H2B Deubiquitination Regulates HCT116 Cell Proliferation through MDM2-p53 Axis.,2022,10.1128/mcb.00434-21,https://pubmed.ncbi.nlm.nih.gov/35072515/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,35318441,USP49 mediates tumor progression and poor prognosis through a YAP1-dependent feedback loop in gastric cancer.,2022,10.1038/s41388-022-02267-0,https://pubmed.ncbi.nlm.nih.gov/35318441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,36702832,USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy.,2023,10.1038/s41419-023-05600-x,https://pubmed.ncbi.nlm.nih.gov/36702832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,35279684,Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation.,2022,10.1038/s41419-022-04675-2,https://pubmed.ncbi.nlm.nih.gov/35279684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,35273362,Genome-wide screening for deubiquitinase subfamily identifies ubiquitin-specific protease 49 as a novel regulator of odontogenesis.,2022,10.1038/s41418-022-00956-7,https://pubmed.ncbi.nlm.nih.gov/35273362/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,31001918,Ubiquitin specific peptidase 49 inhibits non-small cell lung cancer cell growth by suppressing PI3K/AKT signaling.,2019,10.1002/kjm2.12073,https://pubmed.ncbi.nlm.nih.gov/31001918/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,32691951,The long non-coding RNA HLNC1 potentiates hepatocellular carcinoma progression via interaction with USP49.,2020,10.1002/jcla.23462,https://pubmed.ncbi.nlm.nih.gov/32691951/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,31397674,USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication.,2019,10.7554/elife.48318,https://pubmed.ncbi.nlm.nih.gov/31397674/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,30943264,USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA.,2019,10.1371/journal.ppat.1007680,https://pubmed.ncbi.nlm.nih.gov/30943264/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP49,ENSG00000164663,Unsafe,32143396,Differential Expression of DUB Genes in Ovarian Cells Treated with Di-2-Ethylhexyl Phthalate.,2020,10.3390/ijms21051755,https://pubmed.ncbi.nlm.nih.gov/32143396/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,41475333,NEK8 stabilization via USP51-mediated deubiquitination promotes colorectal cancer progression.,2026,10.1016/j.prp.2025.156346,https://pubmed.ncbi.nlm.nih.gov/41475333/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,42642633,Galanin impairs tumor immunity in glioblastoma by promoting infiltration and ferroptosis resistance of myeloid-derived suppressor cells.,2026,10.1038/s43018-026-01221-3,https://pubmed.ncbi.nlm.nih.gov/42642633/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,41273238,Ubiquitin Specific Peptidase 51 Exacerbates Skeletal Muscle Injury by Enhancing APAF1-Mediated Apoptosis and Pyroptosis.,2025,10.1096/fj.202503043r,https://pubmed.ncbi.nlm.nih.gov/41273238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,42508747,Blocking pyruvate carboxylase expression triggers ferroptosis and inhibits non-small cell lung cancer progression.,2026,10.1016/j.canlet.2026.218764,https://pubmed.ncbi.nlm.nih.gov/42508747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,40877392,Regulation of divergent epithelial-to-mesenchymal transition responses via the CDK4/6-USP51 pathway through ZEB1 protein stabilization.,2025,10.1038/s41598-025-17310-9,https://pubmed.ncbi.nlm.nih.gov/40877392/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,40487653,USP51/GRP78/ABCB1 axis confers chemoresistance through decreasing doxorubicin accumulation in triple-negative breast cancer cells.,2025,10.1016/j.apsb.2025.03.004,https://pubmed.ncbi.nlm.nih.gov/40487653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,37816999,USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A.,2023,10.1038/s41418-023-01228-8,https://pubmed.ncbi.nlm.nih.gov/37816999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,39366949,Correction: CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism.,2024,10.1038/s41392-024-01972-4,https://pubmed.ncbi.nlm.nih.gov/39366949/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,37422632,USP51 promotes non-small cell lung carcinoma cell stemness by deubiquitinating TWIST1.,2023,10.1186/s12967-023-04304-2,https://pubmed.ncbi.nlm.nih.gov/37422632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,37386737,USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer.,2023,10.1002/cac2.12460,https://pubmed.ncbi.nlm.nih.gov/37386737/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,36603607,USP51/ZEB1/ACTA2 axis promotes mesenchymal phenotype in gastric cancer and is associated with low cohesion characteristics.,2023,10.1016/j.phrs.2022.106644,https://pubmed.ncbi.nlm.nih.gov/36603607/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,35058607,CDK4/6-USP51 axis regulates lung adenocarcinoma metastasis through ZEB1.,2022,10.1038/s41417-021-00420-7,https://pubmed.ncbi.nlm.nih.gov/35058607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,38753057,"De novo variants in ATXN7L3 lead to developmental delay, hypotonia and distinctive facial features.",2024,10.1093/brain/awae160,https://pubmed.ncbi.nlm.nih.gov/38753057/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,38577450,Ubiquitin-specific protease 21 promotes tumorigenicity and stemness of colorectal cancer by deubiquitinating and stabilizing ZEB1.,2024,10.4251/wjgo.v16.i3.1006,https://pubmed.ncbi.nlm.nih.gov/38577450/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,34188037,Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance.,2021,10.1038/s41467-021-24298-z,https://pubmed.ncbi.nlm.nih.gov/34188037/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,39196911,The effect of ribociclib on the expression levels of miR-141 and CDK4/6-USP51 signaling pathway genes in MCF-7 and MDA-MB-231 cells.,2024,10.1371/journal.pone.0309289,https://pubmed.ncbi.nlm.nih.gov/39196911/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,32468048,Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1.,2020,10.3892/mmr.2020.11188,https://pubmed.ncbi.nlm.nih.gov/32468048/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,32296027,CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism.,2020,10.1038/s41392-020-0118-x,https://pubmed.ncbi.nlm.nih.gov/32296027/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,31217854,FAT4-USP51 complex regulates the proliferation and invasion of endometrial cancer via Hippo pathway.,2019,,https://pubmed.ncbi.nlm.nih.gov/31217854/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,39203006,New Natural and Sustainable Cosmetic Preservative Based on Sugarcane Straw Extract.,2024,10.3390/molecules29163928,https://pubmed.ncbi.nlm.nih.gov/39203006/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,33022275,Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response.,2020,10.1016/j.molcel.2020.09.017,https://pubmed.ncbi.nlm.nih.gov/33022275/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
USP51,ENSG00000247746,Unsafe,14715245,Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.,2004,10.1016/j.bbrc.2003.12.050,https://pubmed.ncbi.nlm.nih.gov/14715245/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,42278056,Single-Cell RNA Sequencing Reveals Dynamic Transcriptional Landscape of Testicular Maturation in Dezhou Donkeys.,2026,10.3390/ani16111621,https://pubmed.ncbi.nlm.nih.gov/42278056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,40482072,Early transcriptional states of spermatogonia and marker expressions in the prepubertal human testis following chemotherapy-induced depletion.,2025,10.1093/humrep/deaf103,https://pubmed.ncbi.nlm.nih.gov/40482072/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,42572996,Impact of gender-affirming hormone therapy on the endocrine axis and male germ cells.,2026,10.1530/raf-26-0032,https://pubmed.ncbi.nlm.nih.gov/42572996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,38486279,Sox9 downregulation in non-obstructive azoospermia by UTF1 and mediator role of POU5F1.,2024,10.1186/s13104-024-06711-0,https://pubmed.ncbi.nlm.nih.gov/38486279/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,41039089,Identification of SENP7 and UTF1/VENTX as new loci influencing clustered protocadherin methylation across blood and brain using a genome-wide association study.,2026,10.1038/s41380-025-03283-8,https://pubmed.ncbi.nlm.nih.gov/41039089/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,39754619,UTF1 Expression is Important for the Generation and Maintenance of Human iPSCs.,2025,10.1007/s12015-024-10836-x,https://pubmed.ncbi.nlm.nih.gov/39754619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,37655584,Effects of adriamycin on cell differentiation and proliferation in rat testis.,2023,10.1080/10520295.2023.2248880,https://pubmed.ncbi.nlm.nih.gov/37655584/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,36760370,Expression and clinical significance of undifferentiated embryonic cell transcription factor 1 in breast cancer.,2023,10.21037/tcr-22-2890,https://pubmed.ncbi.nlm.nih.gov/36760370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,36326833,Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells.,2023,10.15252/embj.2022111251,https://pubmed.ncbi.nlm.nih.gov/36326833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,35360067,Characterization and Survival of Human Infant Testicular Cells After Direct Xenotransplantation.,2022,10.3389/fendo.2022.853482,https://pubmed.ncbi.nlm.nih.gov/35360067/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,33256838,Genetic and histopathological analysis of transverse testicular ectopia without persistent Müllerian duct syndrome: two case reports.,2020,10.1186/s13256-020-02559-7,https://pubmed.ncbi.nlm.nih.gov/33256838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,34257725,MicroRNA-148a-3p inhibits the proliferation of cervical cancer cells by regulating the expression levels of DNMT1 and UTF1.,2021,10.3892/ol.2021.12878,https://pubmed.ncbi.nlm.nih.gov/34257725/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,31947706,Development and Disease-Dependent Dynamics of Spermatogonial Subpopulations in Human Testicular Tissues.,2020,10.3390/jcm9010224,https://pubmed.ncbi.nlm.nih.gov/31947706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,34622232,Single-cell RNA-seq unravels alterations of the human spermatogonial stem cell compartment in patients with impaired spermatogenesis.,2021,10.1016/j.xcrm.2021.100395,https://pubmed.ncbi.nlm.nih.gov/34622232/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,33753728,The Sumo proteome of proliferating and neuronal-differentiating cells reveals Utf1 among key Sumo targets involved in neurogenesis.,2021,10.1038/s41419-021-03590-2,https://pubmed.ncbi.nlm.nih.gov/33753728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,29222434,Embryonic lethality and defective male germ cell development in mice lacking UTF1.,2017,10.1038/s41598-017-17482-z,https://pubmed.ncbi.nlm.nih.gov/29222434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,29097685,Utf1 contributes to intergenerational epigenetic inheritance of pluripotency.,2017,10.1038/s41598-017-14426-5,https://pubmed.ncbi.nlm.nih.gov/29097685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,31671863,Xeno-Free Propagation of Spermatogonial Stem Cells from Infant Boys.,2019,10.3390/ijms20215390,https://pubmed.ncbi.nlm.nih.gov/31671863/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,38432161,Investigation of the differentiation potential of pericyte cells as an alternative source of mesenchymal stem cells.,2024,10.1016/j.acthis.2024.152145,https://pubmed.ncbi.nlm.nih.gov/38432161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,33517544,"An Insight into the Role of UTF1 in Development, Stem Cells, and Cancer.",2021,10.1007/s12015-021-10127-9,https://pubmed.ncbi.nlm.nih.gov/33517544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,30446626,SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling.,2018,10.1242/dev.164160,https://pubmed.ncbi.nlm.nih.gov/30446626/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,35786440,"Comparative genomics of Nocardia seriolae reveals recent importation and subsequent widespread dissemination in mariculture farms in the South Central Coast region, Vietnam.",2022,10.1099/mgen.0.000845,https://pubmed.ncbi.nlm.nih.gov/35786440/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,32228279,Carnitine Diminishes Etoposide Toxic Action on Spermatogonial Self-renewal and Sperm Production in Adult Rats Treated in the Prepubertal Phase.,2020,10.1369/0022155420916274,https://pubmed.ncbi.nlm.nih.gov/32228279/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,23101626,Regulation of pluripotency and self- renewal of ESCs through epigenetic-threshold modulation and mRNA pruning.,2012,10.1016/j.cell.2012.09.023,https://pubmed.ncbi.nlm.nih.gov/23101626/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,25277677,Functional expression and regulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in mouse iPS cell-derived cardiomyocytes after UTF1 -neo selection.,2014,10.1159/000366332,https://pubmed.ncbi.nlm.nih.gov/25277677/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,30048506,Different murine-derived feeder cells alter the definitive endoderm differentiation of human induced pluripotent stem cells.,2018,10.1371/journal.pone.0201239,https://pubmed.ncbi.nlm.nih.gov/30048506/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,25267789,Quantitative detection of human spermatogonia for optimization of spermatogonial stem cell culture.,2014,10.1093/humrep/deu232,https://pubmed.ncbi.nlm.nih.gov/25267789/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,26282538,Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity.,2015,10.1186/s13287-015-0137-7,https://pubmed.ncbi.nlm.nih.gov/26282538/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,19690622,Expression pattern of stemness-related genes in human endometrial and endometriotic tissues.,2009,10.2119/molmed.2009.00068,https://pubmed.ncbi.nlm.nih.gov/19690622/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,24890267,Fluorescence- and magnetic-activated cell sorting strategies to isolate and enrich human spermatogonial stem cells.,2014,10.1016/j.fertnstert.2014.04.036,https://pubmed.ncbi.nlm.nih.gov/24890267/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,24001715,A combined approach facilitates the reliable detection of human spermatogonia in vitro.,2013,10.1093/humrep/det336,https://pubmed.ncbi.nlm.nih.gov/24001715/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
UTF1,ENSG00000171794,Unsafe,24465482,Efficient reprogramming of naïve-like induced pluripotent stem cells from porcine adipose-derived stem cells with a feeder-independent and serum-free system.,2014,10.1371/journal.pone.0085089,https://pubmed.ncbi.nlm.nih.gov/24465482/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,42725393,Synaptobrevin-2 Containing Extracellular Vesicles Are Rapidly Incorporated Into Mammalian Neurons via a Dynamin-Dependent Pathway.,2026,10.1111/jnc.70551,https://pubmed.ncbi.nlm.nih.gov/42725393/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,42797954,Rabies Virus Glycoprotein G Variation Is Associated with Neurovirulence and Reduced Vamp2 Abundance in a Mouse Model of Direct CNS Infection.,2026,10.3390/vetsci13090919,https://pubmed.ncbi.nlm.nih.gov/42797954/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,42582587,Altered synaptic and astrocytic proteins in Lewy body disorders associated with &lt;i&gt;GBA&lt;/i&gt; mutations.,2026,10.1093/braincomms/fcag246,https://pubmed.ncbi.nlm.nih.gov/42582587/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,42270582,Npas4 is involved in synaptic and cognitive function by regulating the transcription of Neuroligin-1 and N-cadherin.,2026,10.1038/s41398-026-03949-z,https://pubmed.ncbi.nlm.nih.gov/42270582/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,41544231,Platelet α-granule cargo packaging and endocytosis are important for normal mouse skin wound healing.,2026,10.1182/bloodadvances.2025017317,https://pubmed.ncbi.nlm.nih.gov/41544231/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,42410626,Terahertz wave stimulation improves visual recognition memory via the activation of excitatory neurons in the perirhinal cortex.,2026,10.1186/s12964-026-03051-3,https://pubmed.ncbi.nlm.nih.gov/42410626/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,42288194,Disruption of dopamine transmission by cholesterol depletion is associated with alterations in protein lipid raft partitioning and actin dynamics.,2026,10.1016/j.neuropharm.2026.111078,https://pubmed.ncbi.nlm.nih.gov/42288194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,42404435,Value of synaptic proteins as biomarkers in amyotrophic lateral sclerosis.,2026,10.1093/braincomms/fcag247,https://pubmed.ncbi.nlm.nih.gov/42404435/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,42705540,Cdc42 coordinates apical membrane formation and secretory granule maturation through v-SNARE maintenance in salivary acinar cells.,2026,10.1016/j.jbc.2026.113521,https://pubmed.ncbi.nlm.nih.gov/42705540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,42125990,VAMP2/SNAP25 promotes the aggressive progression of head and neck cancer by regulating the fate of multivesicular bodies.,2026,10.20892/j.issn.2095-3941.2025.0522,https://pubmed.ncbi.nlm.nih.gov/42125990/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,42378484,Single-Cell Transcriptomics and Mendelian Randomization Analysis Reveal Key Genes in Atrial Fibrillation.,2026,10.1111/jce.70432,https://pubmed.ncbi.nlm.nih.gov/42378484/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,42533122,Light-activated tetanus neurotoxin for conditional proteolysis and inducible synaptic inhibition in vivo.,2026,10.1038/s41592-026-03176-w,https://pubmed.ncbi.nlm.nih.gov/42533122/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,40757880,miR-127-3p regulates osteoporosis progression by targeting VAMP2 to modulate cell differentiation.,2025,10.1530/joe-25-0032,https://pubmed.ncbi.nlm.nih.gov/40757880/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,40549157,APOE4 triggers dysregulated synaptic vesicle release by disrupting SNARE complex assembly.,2025,10.1007/s00018-025-05787-6,https://pubmed.ncbi.nlm.nih.gov/40549157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,42649220,Oligomeric Alpha-Synuclein from neural-derived extracellular vesicles as possible biomarkers of non-motor symptoms in Parkinson's disease.,2026,10.1038/s41531-026-01474-w,https://pubmed.ncbi.nlm.nih.gov/42649220/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,40405270,Influence of co-pathology on CSF and plasma synaptic markers SNAP25 and VAMP2 in Alzheimer's disease and Parkinson's disease.,2025,10.1186/s13195-025-01762-2,https://pubmed.ncbi.nlm.nih.gov/40405270/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,41521857,Inhibitory effects of METTL3 on airway smooth muscle cell proliferation and migration &lt;i&gt;via&lt;/i&gt; lncRNA GAS5/miR-29c-3p/VAMP2 axis.,2026,10.1080/01902148.2025.2605437,https://pubmed.ncbi.nlm.nih.gov/41521857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,41272619,Research on tracheal stenosis based on molecular biomarkers.,2025,10.1186/s12890-025-04034-9,https://pubmed.ncbi.nlm.nih.gov/41272619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,41364313,A Novel Palmitoylation-Related Molecular Signature for Predicting and Therapeutically Targeting Alzheimer's Disease.,2025,10.1007/s12035-025-05574-1,https://pubmed.ncbi.nlm.nih.gov/41364313/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,42272073,ScRNA-seq Data Reveal Gene Upregulation and Downregulation in Oxygen-Induced Retinopathy.,2026,10.12659/msm.951911,https://pubmed.ncbi.nlm.nih.gov/42272073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,40354525,Trehalose dimycolate inhibits phagosome maturation and promotes intracellular &lt;i&gt;M. tuberculosis&lt;/i&gt; growth via noncanonical SNARE interactions.,2025,10.1073/pnas.2423292122,https://pubmed.ncbi.nlm.nih.gov/40354525/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,41962776,High sensitivity of iPSC-derived motor neurons to the human-relevant botulinum neurotoxin serotypes E and F.,2026,10.1016/j.neuro.2026.103446,https://pubmed.ncbi.nlm.nih.gov/41962776/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,39955261,"Biofluid biomarker changes following treatment with sabirnetug (ACU193) in INTERCEPT-AD, a phase 1 trial in early Alzheimer's disease.",2025,10.1016/j.tjpad.2025.100082,https://pubmed.ncbi.nlm.nih.gov/39955261/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,40475761,Transcriptomic insights into the mechanism of action of telomere-related biomarkers in rheumatoid arthritis.,2025,10.3389/fimmu.2025.1585895,https://pubmed.ncbi.nlm.nih.gov/40475761/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,39953608,Identification of endoplasmic reticulum stress and mitochondrial dysfunction related biomarkers in osteoporosis.,2025,10.1186/s41065-025-00387-7,https://pubmed.ncbi.nlm.nih.gov/39953608/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,38115820,Construction and validation of a risk model based on the key SNARE proteins to predict the prognosis and immune microenvironment of gliomas.,2023,10.3389/fnmol.2023.1304224,https://pubmed.ncbi.nlm.nih.gov/38115820/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,38951706,VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates.,2024,10.1038/s41556-024-01456-1,https://pubmed.ncbi.nlm.nih.gov/38951706/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,38531902,Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes.,2024,10.1038/s41467-024-46828-1,https://pubmed.ncbi.nlm.nih.gov/38531902/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,41194174,Mechanical stimulation simulating osteopathic pressing manipulation inhibits nociceptive hypersensitivity and synovial inflammation in knee osteoarthritis rats by modulating trafficking dynamics of transient receptor potentials via complexin2.,2025,10.1186/s13018-025-06414-7,https://pubmed.ncbi.nlm.nih.gov/41194174/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,38990251,Synaptic Vesicle-Related Proteins and Ubiquilin 2 in Cortical Synaptosomes Mediate Cognitive Impairment in Vascular Dementia Rats.,2025,10.1007/s12035-024-04327-w,https://pubmed.ncbi.nlm.nih.gov/38990251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,36248974,Prognostic signature construction of energy metabolism-related genes in pancreatic cancer.,2022,10.3389/fonc.2022.917897,https://pubmed.ncbi.nlm.nih.gov/36248974/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,36977091,Biological and Immunological Characterization of a Functional L-HN Derivative of Botulinum Neurotoxin Serotype F.,2023,10.3390/toxins15030200,https://pubmed.ncbi.nlm.nih.gov/36977091/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAMP2,ENSG00000220205,Unsafe,8760387,Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2.,1996,10.1042/bj3170945,https://pubmed.ncbi.nlm.nih.gov/8760387/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,42702875,"Progesterone Is Associated With Increased Vasohibin-2 Expression, Tubulin Detyrosination, and Paclitaxel Sensitivity in PR-Negative Ovarian Cancer Cells.",2026,10.1002/cnr2.70681,https://pubmed.ncbi.nlm.nih.gov/42702875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,41565265,Roles and Therapeutic Application of Vasohibin-2 in Cancers.,2026,10.1620/tjem.2025.j163,https://pubmed.ncbi.nlm.nih.gov/41565265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,41965682,3D-Mesenchymal stromal cells derived VASH2 alleviates oxidative stress-induced endothelial senescence by mediating α-tubulin detyrosination in systemic sclerosis.,2026,10.1186/s12967-026-08072-7,https://pubmed.ncbi.nlm.nih.gov/41965682/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,41345086,KY216-tubulin complex captures VASH2 to inhibit NSCLC metastasis.,2025,10.1038/s41467-025-66817-2,https://pubmed.ncbi.nlm.nih.gov/41345086/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,40889590,Impact of endogenous vasohibin 1 and vasohibin 2 gene expression on ferroptosis in a mouse cerebral infarction model.,2025,10.1016/j.neuroscience.2025.08.061,https://pubmed.ncbi.nlm.nih.gov/40889590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,41757512,m&lt;sup&gt;5&lt;/sup&gt;C-Modified tRF3b-Cys&lt;sup&gt;GCA&lt;/sup&gt;-23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4.,2026,10.1002/advs.202522294,https://pubmed.ncbi.nlm.nih.gov/41757512/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,41229276,Real-time FRET assay for monitoring detyrosination by TMCP1 and VASH2.,2025,10.1002/pro.70374,https://pubmed.ncbi.nlm.nih.gov/41229276/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,41034039,"Expressions of VEGF, Vasohibin-1, and Vasohibin-2 in Benign Parotid Gland Tumor.",2025,10.1620/tjem.2025.j115,https://pubmed.ncbi.nlm.nih.gov/41034039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,41474745,Peptide-based covalent inhibitor of tubulin detyrosination promotes mesenchymal-to-epithelial transition in lung cancer cells.,2026,10.1073/pnas.2514990123,https://pubmed.ncbi.nlm.nih.gov/41474745/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,39443476,VASH2 enhances KIF3C-mediated EGFR-endosomal recycling to promote aggression and chemoresistance of lung squamous cell carcinoma by increasing tubulin detyrosination.,2024,10.1038/s41419-024-07155-x,https://pubmed.ncbi.nlm.nih.gov/39443476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,37821528,A preliminary study on the mechanism of VASH2 in childhood medulloblastoma.,2023,10.1038/s41598-023-42869-6,https://pubmed.ncbi.nlm.nih.gov/37821528/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,40691305,LINC00654 promotes ovarian cancer progression by facilitating nuclear export of HuR and stabilizing oncogenic mRNAs.,2025,10.1038/s41388-025-03500-2,https://pubmed.ncbi.nlm.nih.gov/40691305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,38278467,High Vasohibin-2 expression correlated with autophagy in proliferative diabetic retinopathy.,2024,10.1016/j.exer.2024.109808,https://pubmed.ncbi.nlm.nih.gov/38278467/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,40483461,Dynamic changes in vasohibin and nitric oxide signaling following surgical resection of head and neck squamous cell carcinoma.,2025,10.1186/s12957-025-03853-8,https://pubmed.ncbi.nlm.nih.gov/40483461/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,37430466,Novel strategy of liver cancer treatment with modified antisense oligonucleotides targeting human vasohibin-2.,2023,10.1111/cas.15897,https://pubmed.ncbi.nlm.nih.gov/37430466/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,38695075,Preventive effects of vasohibin-2-targeting peptide vaccine for diabetic nephropathy.,2024,10.1152/ajprenal.00341.2023,https://pubmed.ncbi.nlm.nih.gov/38695075/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,38220168,Vasohibin-2-Targeting Therapies for the Treatment of Pancreatic Ductal Adenocarcinoma.,2024,10.1620/tjem.2023.j109,https://pubmed.ncbi.nlm.nih.gov/38220168/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,37073150,Knockdown of VASH2 Inhibits the Stemness and EMT Process by Regulating ZEB2 in Colorectal Cancer.,2024,10.2174/1574888x18666230417084221,https://pubmed.ncbi.nlm.nih.gov/37073150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,37704418,Development of a Novel and Simple Anti-Metastatic Cancer Treatment Targeting Vasohibin-2.,2023,10.1620/tjem.2023.j076,https://pubmed.ncbi.nlm.nih.gov/37704418/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,39865093,Tubulin tyrosination/detyrosination regulate the affinity and sorting of intraflagellar transport trains on axonemal microtubule doublets.,2025,10.1038/s41467-025-56098-0,https://pubmed.ncbi.nlm.nih.gov/39865093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,40853733,Development of Low-Nanomolar Covalent Epoxide Inhibitors of Tubulin Detyrosinating Enzymes VASH1&2.,2025,10.1021/acs.jmedchem.5c00980,https://pubmed.ncbi.nlm.nih.gov/40853733/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,42278079,Genomic Signatures of Selection Reveal Breed-Specific and Shared Adaptive Regions in South African Beef Cattle.,2026,10.3390/ani16111645,https://pubmed.ncbi.nlm.nih.gov/42278079/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,31074083,Vasohibin-2 plays an essential role in metastasis of pancreatic ductal adenocarcinoma.,2019,10.1111/cas.14041,https://pubmed.ncbi.nlm.nih.gov/31074083/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,36288859,Inhibition of STAT3 Promotes Effector T Cell Infiltration But also Immunosuppression in the HCC Tumor Microenvironment.,2022,10.21873/anticanres.16027,https://pubmed.ncbi.nlm.nih.gov/36288859/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,35145607,Antitumor effect of isoquercetin on tissue vasohibin expression and colon cancer vasculature.,2022,10.18632/oncotarget.28181,https://pubmed.ncbi.nlm.nih.gov/35145607/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,24595063,Vasohibin 2 decreases the cisplatin sensitivity of hepatocarcinoma cell line by downregulating p53.,2014,10.1371/journal.pone.0090358,https://pubmed.ncbi.nlm.nih.gov/24595063/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,24118388,In vivo delivery of siRNA targeting vasohibin-2 decreases tumor angiogenesis and suppresses tumor growth in ovarian cancer.,2013,10.1111/cas.12297,https://pubmed.ncbi.nlm.nih.gov/24118388/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,25269476,MiR200-upregulated Vasohibin 2 promotes the malignant transformation of tumors by inducing epithelial-mesenchymal transition in hepatocellular carcinoma.,2014,10.1186/s12964-014-0062-x,https://pubmed.ncbi.nlm.nih.gov/25269476/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,34040253,MARK4 controls ischaemic heart failure through microtubule detyrosination.,2021,10.1038/s41586-021-03573-5,https://pubmed.ncbi.nlm.nih.gov/34040253/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VASH2,ENSG00000143494,Unsafe,31320544,Epigenetic regulation of histone H3 in the process of hepatocellular tumorigenesis.,2019,10.1042/bsr20191815,https://pubmed.ncbi.nlm.nih.gov/31320544/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,42570147,Serum miR-369-3p Downregulation Correlates with Poor Prognosis in Acute Ischemic Stroke and Mitigates Endothelial Injury by Targeting VAV3.,2026,10.1007/s11064-026-04852-1,https://pubmed.ncbi.nlm.nih.gov/42570147/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,42794834,Time-Resolved Network Entropy Analysis Identifies a CTNND1-VAV3 Subnetwork in Gefitinib-Resistant NSCLC.,2026,10.3390/ijms27188409,https://pubmed.ncbi.nlm.nih.gov/42794834/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,42248330,VAV3 is associated with atherosclerosis and ox-LDL-induced endothelial dysfunctional remodeling.,2026,10.1016/j.mvr.2026.104966,https://pubmed.ncbi.nlm.nih.gov/42248330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,42083314,Indirubin Sensitizes Prostate Cancer to Docetaxel by Inhibiting Autophagy Through the circ-Vav3/miR-204-5p/MAPK1 Pathway.,2026,10.1002/jbt.70884,https://pubmed.ncbi.nlm.nih.gov/42083314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,42450257,Serum EV-Derived rno-let-7b-5p Is Associated with Lung-Adipose Alterations in Allergic Asthma.,2026,10.3390/ijms27135989,https://pubmed.ncbi.nlm.nih.gov/42450257/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,42008609,Single-cell RNA sequencing identifies microglial state changes associated with iTBS after ischemia-reperfusion injury.,2026,10.1371/journal.pone.0346888,https://pubmed.ncbi.nlm.nih.gov/42008609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,42527560,Multi-ancestry genome-wide association analyses provide insights into the genetic basis of Hashimoto's thyroiditis.,2026,10.1038/s41588-026-02704-w,https://pubmed.ncbi.nlm.nih.gov/42527560/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,42025389,Gut microbiota-derived trimethylamine-N-oxide protects pulmonary vascular barrier integrity via Vav guanine nucleotide exchange factor 3 (VAV3)-mediated cytoskeletal remodelling in acute lung injury.,2026,10.1111/bph.70449,https://pubmed.ncbi.nlm.nih.gov/42025389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,42305062,Silencing miR-208a-3p promotes autophagy and attenuates high glucose-triggered podocyte injury by activating VAV3/AKT/mTOR pathway.,2026,10.4149/gpb_2026008,https://pubmed.ncbi.nlm.nih.gov/42305062/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,42450011,"Translational Validation of a Novel Multi-Locus ctDNA Methylation Assay for Early Detection and Stratification of Colorectal Cancer: An Exploratory Prospective, Case-Control Study.",2026,10.3390/ijms27135738,https://pubmed.ncbi.nlm.nih.gov/42450011/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,41354017,"Vav3, a potential diagnostic and prognostic marker of diabetes, regulates glycolipid metabolism.",2026,10.1016/j.mam.2025.101429,https://pubmed.ncbi.nlm.nih.gov/41354017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,42419155,Systemic infections alter cortical transcriptional signatures in Alzheimer's disease.,2026,10.1016/j.neurobiolaging.2026.06.010,https://pubmed.ncbi.nlm.nih.gov/42419155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,40618919,Unravelling the roles of Vav3 in cytoskeletal control and angiogenesis.,2025,10.1016/j.lfs.2025.123834,https://pubmed.ncbi.nlm.nih.gov/40618919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,41849028,Lactate Metabolism-Immune Regulation-Related Gene Signature in Lower-Grade Gliomas: Prognostic Model Development and Immune Characterization.,2026,10.1096/fj.202503738rr,https://pubmed.ncbi.nlm.nih.gov/41849028/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,42056214,Resibufogenin promotes angiogenesis via the VAV3-mediated ITGA5-VEGF signaling axis in macrophages to alleviate myocardial infarction.,2026,10.1038/s41401-026-01799-5,https://pubmed.ncbi.nlm.nih.gov/42056214/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,40855003,Bcl11a deficiency in cerebellar Purkinje cells causes ataxia and autistic-like behavior by altering Vav3.,2026,10.1038/s41380-025-03175-x,https://pubmed.ncbi.nlm.nih.gov/40855003/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,39987600,Circular RNA Vav3 mediated ALV-J inhibition of autophagy by modulating the gga-miR-375/CIP2A axis and activating AKT.,2025,10.1016/j.psj.2025.104923,https://pubmed.ncbi.nlm.nih.gov/39987600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,39200159,Prognostic Significance of VAV3 Gene Variants and Expression in Renal Cell Carcinoma.,2024,10.3390/biomedicines12081694,https://pubmed.ncbi.nlm.nih.gov/39200159/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,41516108,HuR-Targeted Small Molecules Reduce &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; Adhesion in Cystic Fibrosis Airway Epithelial Cells.,2025,10.3390/ijms27010232,https://pubmed.ncbi.nlm.nih.gov/41516108/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,42517221,Prospective evaluation of a multi-gene cfDNA methylation assay for CRC screening in a high-risk cohort.,2026,10.1515/cclm-2026-0185,https://pubmed.ncbi.nlm.nih.gov/42517221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,40496857,Machine learning-based diagnostic and prognostic models for breast cancer: a new frontier on the clinical application of natural killer cell-related gene signatures in precision medicine.,2025,10.3389/fimmu.2025.1581982,https://pubmed.ncbi.nlm.nih.gov/40496857/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,39998699,Activation of RHO-GTPase gene pattern correlates with adverse clinical outcome and immune microenvironment in clear cell renal cell carcinoma.,2025,10.1007/s10238-025-01593-3,https://pubmed.ncbi.nlm.nih.gov/39998699/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,39715471,Genome-wide CRISPR/Cas9 screen identifies AraC-daunorubicin-etoposide response modulators associated with outcomes in pediatric AML.,2025,10.1182/bloodadvances.2024014157,https://pubmed.ncbi.nlm.nih.gov/39715471/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,41614931,Genome-Wide Insights into Intermittent Milking Behavior of Pandharpuri Buffalo.,2026,10.3390/cimb48010101,https://pubmed.ncbi.nlm.nih.gov/41614931/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,37591108,The role of Vav3 expression for inflammation and cell death during experimental myocardial infarction.,2023,10.1016/j.clinsp.2023.100273,https://pubmed.ncbi.nlm.nih.gov/37591108/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,40379756,Identification of natural killer cell-characteristic genes in atherosclerosis based on bioinformatics analysis.,2025,10.1038/s41598-025-98524-9,https://pubmed.ncbi.nlm.nih.gov/40379756/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,41915463,Lentinula edodes Cultured Extract Intake at Puberty Mitigates Inflammatory Signals at the Mammary Glands by the Involvement of Epigenetic Mechanisms in BALB/c Mice.,2026,10.1155/tbj/2122220,https://pubmed.ncbi.nlm.nih.gov/41915463/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,41516402,Subtype-Specific m&lt;sup&gt;6&lt;/sup&gt;A circRNA Methylation Patterns Identify Epigenetic Biomarker Candidates of Potential Diagnostic and Prognostic Significance in Breast Cancer.,2026,10.3390/ijms27010529,https://pubmed.ncbi.nlm.nih.gov/41516402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,36602863,Targeting HuR-Vav3 mRNA interaction prevents Pseudomonas aeruginosa adhesion to the cystic fibrosis airway epithelium.,2023,10.1172/jci.insight.161961,https://pubmed.ncbi.nlm.nih.gov/36602863/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,40782057,Brain Transcriptome Analysis Reveals Exercise Improves Methamphetamine-Induced Impairments in Mouse Learning and Memory Abilities.,2025,10.1111/adb.70077,https://pubmed.ncbi.nlm.nih.gov/40782057/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,36539408,DC vaccines loaded with glioma cells killed by photodynamic therapy induce Th17 anti-tumor immunity and provide a four-gene signature for glioma prognosis.,2022,10.1038/s41419-022-05514-0,https://pubmed.ncbi.nlm.nih.gov/36539408/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,40626048,Identification of potential miRNA biomarkers for neurobrucellosis diagnosis.,2025,10.3389/fphys.2025.1463597,https://pubmed.ncbi.nlm.nih.gov/40626048/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,11094073,"Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.",2000,10.1128/mcb.20.24.9212-9224.2000,https://pubmed.ncbi.nlm.nih.gov/11094073/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VAV3,ENSG00000134215,Unsafe,9705494,Non-stoichiometric reduced complexity probes for cDNA arrays.,1998,10.1093/nar/26.17.3883,https://pubmed.ncbi.nlm.nih.gov/9705494/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,42144399,VCPIP1 drives diabetic cardiomyopathy by deubiquitinating AMPKγ1 and preventing AMPKα-γ subunit assembly in cardiomyocytes.,2026,10.1038/s41392-026-02701-9,https://pubmed.ncbi.nlm.nih.gov/42144399/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,41748310,A GJA1 Variant Triggers Earlier SPG4 Onset by Destabilizing Deubiquitinase VCPIP1 to Lower SPASTIN Levels.,2026,10.1002/mds.70248,https://pubmed.ncbi.nlm.nih.gov/41748310/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,40581931,VCPIP1 potentiates innate immune responses by non-catalytically reducing the ubiquitination of IRAK1/2.,2025,10.1016/j.celrep.2025.115931,https://pubmed.ncbi.nlm.nih.gov/40581931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,40436845,VCPIP1 facilitates pancreatic adenocarcinoma progression via Hippo/YAP signaling.,2025,10.1038/s41419-025-07746-2,https://pubmed.ncbi.nlm.nih.gov/40436845/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,39796135,Analyses of the MYBL1 Gene in Triple Negative Breast Cancer: Evidence of Regulation of the VCPIP1 Gene and Identification of a Specific Exon Overexpressed in Tumor Cell Lines.,2024,10.3390/ijms26010279,https://pubmed.ncbi.nlm.nih.gov/39796135/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,40865405,VCPIP1 ameliorates sepsis-associated encephalopathy by promoting microglia autophagy via the PI3K/AKT/mTOR pathway.,2025,10.1016/j.intimp.2025.115417,https://pubmed.ncbi.nlm.nih.gov/40865405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,40877265,Structural basis of VCP-VCPIP1-p47 ternary complex in Golgi maintenance.,2025,10.1038/s41467-025-63161-3,https://pubmed.ncbi.nlm.nih.gov/40877265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,39494904,Identification and characterization of host factor VCPIP1 as a multi-functional positive regulator of hepatitis B virus.,2024,10.1128/jvi.01581-24,https://pubmed.ncbi.nlm.nih.gov/39494904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,39234822,Molecular Basis of VCPIP1 and P97/VCP Interaction Reveals Its Functions in Post-Mitotic Golgi Reassembly.,2024,10.1002/advs.202403417,https://pubmed.ncbi.nlm.nih.gov/39234822/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,40085114,"Structural insights into the coupling between VCP, an essential unfoldase, and a deubiquitinase.",2025,10.1083/jcb.202410148,https://pubmed.ncbi.nlm.nih.gov/40085114/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,39550842,VCPIP1 negatively regulates NF-κB signaling pathways by deubiquitinating and stabilizing Erbin in MDP-stimulated macrophages.,2024,10.1016/j.intimp.2024.113622,https://pubmed.ncbi.nlm.nih.gov/39550842/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,38072049,VCIP135 associates with both the N- and C-terminal regions of p97 ATPase.,2024,10.1016/j.jbc.2023.105540,https://pubmed.ncbi.nlm.nih.gov/38072049/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,38473786,Characterization of MYBL1 Gene in Triple-Negative Breast Cancers and the Genes' Relationship to Alterations Identified at the Chromosome 8q Loci.,2024,10.3390/ijms25052539,https://pubmed.ncbi.nlm.nih.gov/38473786/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,32649882,Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging.,2020,10.1016/j.molcel.2020.06.027,https://pubmed.ncbi.nlm.nih.gov/32649882/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,37175532,Identification and Characterization of Proteins That Are Involved in RTP1S-Dependent Transport of Olfactory Receptors.,2023,10.3390/ijms24097829,https://pubmed.ncbi.nlm.nih.gov/37175532/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,35695579,Hepatitis B Virus X Protein Is Stabilized by the Deubiquitinating Enzyme VCPIP1 in a Ubiquitin-Independent Manner by Recruiting the 26S Proteasome Subunit PSMC3.,2022,10.1128/jvi.00611-22,https://pubmed.ncbi.nlm.nih.gov/35695579/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,36915397,Alternative Polyadenylation Results in mRNA Transcript Instability in Gestational Diabetes Mellitus.,2023,10.2147/dmso.s400283,https://pubmed.ncbi.nlm.nih.gov/36915397/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,35729157,Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA.,2022,10.1038/s41392-022-01017-8,https://pubmed.ncbi.nlm.nih.gov/35729157/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,37176056,miR-145-3p Inhibits MuSCs Proliferation and Mitochondria Mass via Targeting MYBL1 in Jianzhou Big-Eared Goats.,2023,10.3390/ijms24098341,https://pubmed.ncbi.nlm.nih.gov/37176056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,34646144,Screening of a Focused Ubiquitin-Proteasome Pathway Inhibitor Library Identifies Small Molecules as Novel Modulators of Botulinum Neurotoxin Type A Toxicity.,2021,10.3389/fphar.2021.763950,https://pubmed.ncbi.nlm.nih.gov/34646144/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,28584101,Deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication.,2017,10.1073/pnas.1621076114,https://pubmed.ncbi.nlm.nih.gov/28584101/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,36754960,Accelerating inhibitor discovery for deubiquitinating enzymes.,2023,10.1038/s41467-023-36246-0,https://pubmed.ncbi.nlm.nih.gov/36754960/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,27685836,Immune complexome analysis reveals the specific and frequent presence of immune complex antigens in lung cancer patients: A pilot study.,2017,10.1002/ijc.30455,https://pubmed.ncbi.nlm.nih.gov/27685836/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,25302364,The biology of A20-like molecules.,2014,10.1007/978-1-4939-0398-6_3,https://pubmed.ncbi.nlm.nih.gov/25302364/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCPIP1,ENSG00000175073,Unsafe,28881649,Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry.,2017,10.18632/oncotarget.17261,https://pubmed.ncbi.nlm.nih.gov/28881649/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX2,ENSG00000177504,Unsafe,42231942,An integrative omics-guided druggability analysis of VCX2 in hepatocellular carcinoma using Peruvian natural products.,2026,10.3389/fbinf.2026.1822441,https://pubmed.ncbi.nlm.nih.gov/42231942/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX2,ENSG00000177504,Unsafe,33634013,The Cancer/Testis Antigen Gene VCX2 Is Rarely Expressed in Malignancies but Can Be Epigenetically Activated Using DNA Methyltransferase and Histone Deacetylase Inhibitors.,2020,10.3389/fonc.2020.584024,https://pubmed.ncbi.nlm.nih.gov/33634013/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX2,ENSG00000177504,Unsafe,40580591,Identification of the differences in molecular networks between idiopathic pulmonary fibrosis and lung squamous cell carcinoma using machine learning.,2025,10.1016/j.compbiolchem.2025.108560,https://pubmed.ncbi.nlm.nih.gov/40580591/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX2,ENSG00000177504,Unsafe,37347056,Case report: Sex-specific characteristics of epilepsy phenotypes associated with Xp22.31 deletion: a case report and review.,2023,10.3389/fgene.2023.1025390,https://pubmed.ncbi.nlm.nih.gov/37347056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX2,ENSG00000177504,Unsafe,28122887,Expanding the genetic spectrum of ANOS1 mutations in patients with congenital hypogonadotropic hypogonadism.,2017,10.1093/humrep/dew354,https://pubmed.ncbi.nlm.nih.gov/28122887/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VCX2,ENSG00000177504,Unsafe,18076704,"Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis.",2008,10.1111/j.1365-2133.2007.08373.x,https://pubmed.ncbi.nlm.nih.gov/18076704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,41522855,"Central nervous system schwannoma, VGLL-fused (EWSR1::VGLL1 fusion) with neuroblastoma-like cell dense areas in the frontal lobe of a young man with schwannomatosis due to a germline LZTR1 mutation.",2026,10.17879/freeneuropathology-2026-8898,https://pubmed.ncbi.nlm.nih.gov/41522855/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,42351298,VGLL-fused intraparenchymal schwannoma with EWSR1::VGLL1 fusion: integrated clinicopathological and molecular characterization.,2026,10.1186/s40478-026-02355-2,https://pubmed.ncbi.nlm.nih.gov/42351298/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,41540017,Distinguishing benign from pathogenic duplications involving GPR101 and VGLL1-adjacent enhancers in the clinical setting with the bioinformatic tool POSTRE.,2026,10.1038/s41525-025-00548-7,https://pubmed.ncbi.nlm.nih.gov/41540017/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,41284866,VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment.,2025,10.1073/pnas.2508432122,https://pubmed.ncbi.nlm.nih.gov/41284866/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,39713960,VGLL fusions define a new class of intraparenchymal central nervous system schwannoma.,2025,10.1093/neuonc/noae269,https://pubmed.ncbi.nlm.nih.gov/39713960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,40980038,Integrated bioinformatics and machine learning identify S100A9 and VGLL1 as hub genes for schizophrenia.,2025,10.3389/fpsyt.2025.1621219,https://pubmed.ncbi.nlm.nih.gov/40980038/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,38912065,Placental co-transcriptional activator Vestigial-like 1 (VGLL1) drives tumorigenesis via increasing transcription of proliferation and invasion genes.,2024,10.3389/fonc.2024.1403052,https://pubmed.ncbi.nlm.nih.gov/38912065/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,39356622,Induction of the TEAD Coactivator VGLL1 by Estrogen Receptor-Targeted Therapy Drives Resistance in Breast Cancer.,2024,10.1158/0008-5472.can-24-0013,https://pubmed.ncbi.nlm.nih.gov/39356622/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,40684399,Non-penetrant Xq26.3 duplication involving the invariant TAD border: clinical evidence for the VGLL1 region as the GPR101 pituitary enhancer of X-linked acrogigantism.,2025,10.1007/s11102-025-01559-4,https://pubmed.ncbi.nlm.nih.gov/40684399/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,40300335,Vestigial-like family member 1 (VGLL1): An emerging candidate in tumor progression.,2025,10.1016/j.bbrc.2025.151889,https://pubmed.ncbi.nlm.nih.gov/40300335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,38439973,N6-methyladenosine-modified VGLL1 promotes ovarian cancer metastasis through high-mobility group AT-hook 1/Wnt/β-catenin signaling.,2024,10.1016/j.isci.2024.109245,https://pubmed.ncbi.nlm.nih.gov/38439973/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,38417636,VGLL1 stabilization of cytoplasmic TAZ promotes EGFR expression and maintains tumor initiating cells in breast cancer independent of TEAD.,2024,10.1016/j.cellsig.2024.111120,https://pubmed.ncbi.nlm.nih.gov/38417636/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,41386839,Identification of high-risk signatures and therapeutic targets through molecular characterization and immune profiling of TP53-mutant breast cancer.,2025,10.1016/j.jgeb.2025.100574,https://pubmed.ncbi.nlm.nih.gov/41386839/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,38233381,VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification.,2024,10.1038/s41467-024-44780-8,https://pubmed.ncbi.nlm.nih.gov/38233381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,33087697,Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers.,2020,10.1038/s41467-020-19141-w,https://pubmed.ncbi.nlm.nih.gov/33087697/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,37004960,"Vestigial-like 1 (VGLL1): An ancient co-transcriptional activator linking wing, placenta, and tumor development.",2023,10.1016/j.bbcan.2023.188892,https://pubmed.ncbi.nlm.nih.gov/37004960/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,39484215,COADREADx: A comprehensive algorithmic dissection of colorectal cancer unravels salient biomarkers and actionable insights into its discrete progression.,2024,10.7717/peerj.18347,https://pubmed.ncbi.nlm.nih.gov/39484215/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,34373716,"Weighted gene co-expression network analysis of the association between upregulated AMD1, EN1 and VGLL1 and the progression and poor prognosis of breast cancer.",2021,10.3892/etm.2021.10462,https://pubmed.ncbi.nlm.nih.gov/34373716/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,35202564,Duplications disrupt chromatin architecture and rewire GPR101-enhancer communication in X-linked acrogigantism.,2022,10.1016/j.ajhg.2022.02.002,https://pubmed.ncbi.nlm.nih.gov/35202564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,36613819,TNF-α Secreted from Macrophages Increases the Expression of Prometastatic Integrin αV in Gastric Cancer.,2022,10.3390/ijms24010376,https://pubmed.ncbi.nlm.nih.gov/36613819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,31816819,PI3K/AKT/β-Catenin Signaling Regulates Vestigial-Like 1 Which Predicts Poor Prognosis and Enhances Malignant Phenotype in Gastric Cancer.,2019,10.3390/cancers11121923,https://pubmed.ncbi.nlm.nih.gov/31816819/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,32793503,Multiple Roles of Vestigial-Like Family Members in Tumor Development.,2020,10.3389/fonc.2020.01266,https://pubmed.ncbi.nlm.nih.gov/32793503/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,37075810,LOGGIC Core BioClinical Data Bank: Added clinical value of RNA-Seq in an international molecular diagnostic registry for pediatric low-grade glioma patients.,2023,10.1093/neuonc/noad078,https://pubmed.ncbi.nlm.nih.gov/37075810/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,30034932,VGLL4 is a transcriptional cofactor acting as a novel tumor suppressor via interacting with TEADs.,2018,,https://pubmed.ncbi.nlm.nih.gov/30034932/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VGLL1,ENSG00000102243,Unsafe,28733631,VGLL4 Selectively Represses YAP-Dependent Gene Induction and Tumorigenic Phenotypes in Breast Cancer.,2017,10.1038/s41598-017-06227-7,https://pubmed.ncbi.nlm.nih.gov/28733631/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,42717782,KIAA1429 promotes chondrocyte senescence and ferroptosis in osteoarthritis progression by facilitating m6A-mediated downregulation of USP3.,2026,10.4149/gpb_2026020,https://pubmed.ncbi.nlm.nih.gov/42717782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,40723784,"The Multifaceted Role of VIRMA, a Core Component of the Methyltransferase Complex, in Cancer and Cancer Therapy.",2025,10.3390/biom15070912,https://pubmed.ncbi.nlm.nih.gov/40723784/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,40611263,Total m6A RNA levels and VIRMA expression as potential diagnostic and prognostic markers in oral squamous cell carcinoma.,2025,10.1186/s13000-025-01678-3,https://pubmed.ncbi.nlm.nih.gov/40611263/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,42635958,p300-Mediated H3K18 Lactylation Drives Radiation-Induced Pulmonary Fibrosis via VIRMA-Dependent m6A Modification of GATA3.,2026,10.1002/advs.77328,https://pubmed.ncbi.nlm.nih.gov/42635958/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,42627048,KIAA1429 knockdown alleviates osteosarcoma  progression by destabilizing SLC7A11 mRNA via m6A methylation to promote ferroptosis.,2026,10.3892/ijo.2026.5929,https://pubmed.ncbi.nlm.nih.gov/42627048/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,41146006,KIAA1429-mediated M&lt;sup&gt;6&lt;/sup&gt;A methylation inhibits osteoclast differentiation via stabilizing Lrp4 mRNA and protects against osteoporosis.,2025,10.1186/s11658-025-00800-z,https://pubmed.ncbi.nlm.nih.gov/41146006/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,40640307,KIAA1429 promotes non-small-cell lung cancer cell proliferation through the TRERNA1/HOXA6 axis.,2025,10.1038/s41598-025-09441-w,https://pubmed.ncbi.nlm.nih.gov/40640307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,41907423,KIAA1429 promotes clear cell renal cell carcinoma progression by regulating MYC mRNA stability.,2026,10.1016/j.isci.2026.115198,https://pubmed.ncbi.nlm.nih.gov/41907423/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,40069867,m6A transferase KIAA1429 mediates the upregulation of LncRNA LINC00968 promoting the progression of gastric cancer cells.,2025,10.1186/s41065-025-00393-9,https://pubmed.ncbi.nlm.nih.gov/40069867/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,41860402,VIRMA modulates function of photoreceptor cells through m6A modification and alternative splicing.,2026,10.1172/jci.insight.197880,https://pubmed.ncbi.nlm.nih.gov/41860402/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,41345190,KIAA1429 impairs anti-tumor immunity via regulation of PD-L1 and CD8&lt;sup&gt;+&lt;/sup&gt; T cells in colorectal cancer.,2025,10.1038/s41598-025-27586-6,https://pubmed.ncbi.nlm.nih.gov/41345190/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,41826832,USP7 Drives Atherosclerosis by Promoting Ferroptosis in Vascular Endothelial Cells via the KIAA1429/NEAT1/CTCF Axis.,2026,10.1186/s12575-026-00331-7,https://pubmed.ncbi.nlm.nih.gov/41826832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,41622440,The m 6 A writer VIRMA regulates the developmental elimination of retinal astrocytes and retinal vascular integrity maintenance.,2026,10.4103/nrr.nrr-d-25-00295,https://pubmed.ncbi.nlm.nih.gov/41622440/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,42437826,KIAA1429 promotes gallbladder cancer progression through m6A-dependent post-transcriptional modification of KIF20A.,2026,10.1038/s41598-026-61349-1,https://pubmed.ncbi.nlm.nih.gov/42437826/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,41085851,Long non-coding RNA FEZF1-AS1 suppresses ferroptosis in multiple myeloma cells through KIAA1429-mediated m6A modification.,2025,10.1007/s13577-025-01274-z,https://pubmed.ncbi.nlm.nih.gov/41085851/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,37705505,KIAA1429/VIRMA promotes breast cancer progression by m&lt;sup&gt;6&lt;/sup&gt; A-dependent cytosolic HAS2 stabilization.,2023,10.15252/embr.202255506,https://pubmed.ncbi.nlm.nih.gov/37705505/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,40577453,VIRMA-mediated m&lt;sup&gt;6&lt;/sup&gt;A modification regulates forebrain formation through modulating ribosome biogenesis.,2025,10.1126/sciadv.adq9643,https://pubmed.ncbi.nlm.nih.gov/40577453/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,41190085,KIAA1429 in non-small cell lung cancer: bridging m6A epigenetics to therapeutic innovation.,2025,10.3389/fsurg.2025.1643120,https://pubmed.ncbi.nlm.nih.gov/41190085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,39456252,N6-Methyladenosine Methyltransferase Component KIAA1429 Is a Potential Target of Cancer Therapy.,2024,10.3390/biom14101319,https://pubmed.ncbi.nlm.nih.gov/39456252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,40747381,"KIAA1429-mediated ZFPM2-AS1 m&lt;sup&gt;6&lt;/sup&gt;A modification promotes the proliferation, migration and invasion of osteosarcoma cells.",2025,10.3892/ol.2025.15199,https://pubmed.ncbi.nlm.nih.gov/40747381/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,38843497,Role and mechanism of KIAA1429 in regulating cellular ferroptosis and radioresistance in colorectal cancer.,2024,10.17305/bb.2024.10313,https://pubmed.ncbi.nlm.nih.gov/38843497/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,40254620,VIRMA promotes NSCLC progression by modifying ADAR m&lt;sup&gt;6&lt;/sup&gt;A and increasing the activity of the TGF-β signaling pathway.,2025,10.1038/s41598-025-97237-3,https://pubmed.ncbi.nlm.nih.gov/40254620/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,40436288,IL-6/KIAA1429 promotes ferroptosis resistance in endometrial cancer through m6A modification of DDIT3.,2025,10.1016/j.cellsig.2025.111906,https://pubmed.ncbi.nlm.nih.gov/40436288/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,37606975,"Pan-cancer analysis and experimental validation revealed the m6A methyltransferase KIAA1429 as a potential biomarker for diagnosis, prognosis, and immunotherapy.",2023,10.18632/aging.204968,https://pubmed.ncbi.nlm.nih.gov/37606975/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,41815123,Identification of immune-related targets of N6-methyladenosine regulators in hepatocellular carcinoma via RNA-seq analysis.,2026,10.21037/tcr-2025-1417,https://pubmed.ncbi.nlm.nih.gov/41815123/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,40301310,Acetylated KIAA1429 by TIP60 facilitates metastasis and immune evasion of hepatocellular carcinoma via N6-methyladenosine-KDM5B-mediated regulation of FoxO1.,2025,10.1038/s41420-025-02462-4,https://pubmed.ncbi.nlm.nih.gov/40301310/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,41378023,Prognostic potential of N6-methyladenosine methylation-associated genes in lung adenocarcinoma.,2025,10.21037/tcr-2025-aw-2305,https://pubmed.ncbi.nlm.nih.gov/41378023/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,41513610,VIRMA/IGF2BP3-mediated ANLN upregulation promotes intrahepatic cholangiocarcinoma growth by forming a positive feedback loop with RhoA/YAP1/TEAD1 signaling pathway.,2026,10.1038/s41419-025-08197-5,https://pubmed.ncbi.nlm.nih.gov/41513610/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,41228380,The Epitranscriptomic Landscape of Gastric Cancer Stem Cells: The Emerging Role of m&lt;sup&gt;6&lt;/sup&gt;A RNA Modifications.,2025,10.3390/cancers17213589,https://pubmed.ncbi.nlm.nih.gov/41228380/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,39499390,Mechanism of the KIAA1429/KLF1/PD-L1 Axis in Regulating Immune Escape in Non-small Cell Lung Cancer.,2025,10.1007/s12013-024-01592-3,https://pubmed.ncbi.nlm.nih.gov/39499390/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,40183263,Construction of a Single-cell Atlas of Thyroid Cancer,2026,10.2174/0118715303359688250209090544,https://pubmed.ncbi.nlm.nih.gov/40183263/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,41017455,Extracellular Vesicle-Packaged circTAX1BP1 from Cancer-Associated Fibroblasts Regulates RNA m6A Modification through Lactylation of VIRMA in Colorectal Cancer Cells.,2025,10.1002/advs.202514008,https://pubmed.ncbi.nlm.nih.gov/41017455/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,42724890,Development of m6A-related prognostic models for survival in lung squamous cell carcinoma with different PD-L1 expression levels.,2026,10.21037/tcr-2026-0829,https://pubmed.ncbi.nlm.nih.gov/42724890/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,41613364,"Machine learning-based comprehensive analysis of m6A RNA methylation regulators in colorectal cancer: implications for prognosis, immune microenvironment, and immunotherapy response.",2025,10.3389/ebm.2025.10776,https://pubmed.ncbi.nlm.nih.gov/41613364/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VIRMA,ENSG00000164944,Unsafe,41120498,​Identification of a novel m6A RNA methylation regulator-based signature for prognosis and immune landscape prediction in hepatocellular carcinoma.,2025,10.1038/s41598-025-20551-3,https://pubmed.ncbi.nlm.nih.gov/41120498/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42531760,Gene expression of anticoagulant rodenticide target genes (vkorc1 and vkorc1l1) in a non-target wildlife species: The eagle owl (Bubo bubo).,2026,10.1016/j.ecoenv.2026.120587,https://pubmed.ncbi.nlm.nih.gov/42531760/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42321255,VKORC1L1-mediated vitamin K recycling counters ferroptosis to promote endothelial repair.,2026,10.1038/s41598-026-54463-7,https://pubmed.ncbi.nlm.nih.gov/42321255/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42801138,"Allelic Frequency of Single-Nucleotide Polymorphisms in CYP2C9, VKORC1, and CYP4F2 Genetic Variants in Patients With Mechanical Heart Valves on Acenocoumarol Drug Therapy.",2026,10.7759/cureus.115278,https://pubmed.ncbi.nlm.nih.gov/42801138/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42123380,Isomer-Dependent Pharmacokinetic Behavior and VKOR Interactions of Second-Generation Anticoagulant Rodenticides: An Integrated In Vivo-In Vitro-In Silico Investigation.,2026,10.3390/ijms27093794,https://pubmed.ncbi.nlm.nih.gov/42123380/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42660115,γ-glutamyl carboxylase inhibition by Anisindione.,2026,10.1016/j.str.2026.08.002,https://pubmed.ncbi.nlm.nih.gov/42660115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42570116,Vitamin K in photosynthetic organisms.,2026,10.1007/s00425-026-05122-8,https://pubmed.ncbi.nlm.nih.gov/42570116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,41597466,Association Between VKORC1 Gene Polymorphisms and Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis.,2026,10.3390/medicina62010180,https://pubmed.ncbi.nlm.nih.gov/41597466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42178279,An ordinary differential equation-based integrated pharmacokinetic-pharmacodynamic model for predicting anticoagulant responses to warfarin and diphacinone across rodent and bat species.,2026,10.1292/jvms.26-0177,https://pubmed.ncbi.nlm.nih.gov/42178279/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42761110,"LP533401 treatment alters vitamin K metabolism, bone Gla-OC/Glu-OC ratios, and improves mineral status of the skeleton in rats with chronic kidney disease.",2026,10.3389/fphar.2026.1793663,https://pubmed.ncbi.nlm.nih.gov/42761110/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42005663,Systematic Druggable Genome-Wide Analysis Identifies Therapeutic Targets for Aging: A Mendelian Randomization Study.,2026,10.1002/hsr2.72044,https://pubmed.ncbi.nlm.nih.gov/42005663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,38762182,Warfarin analogs target disulfide bond-forming enzymes and suggest a residue important for quinone and coumarin binding.,2024,10.1016/j.jbc.2024.107383,https://pubmed.ncbi.nlm.nih.gov/38762182/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42574618,Giant viruses encode vitamin K-based redox modules for lipid modification.,2026,10.1073/pnas.2610764123,https://pubmed.ncbi.nlm.nih.gov/42574618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42563458,Purine Metabolism-Related Pathogenic Genes in Trigeminal Neuralgia: A Multiomics Mendelian Randomization Study.,2026,10.1155/prm/1640039,https://pubmed.ncbi.nlm.nih.gov/42563458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,41861711,Bioengineered baculovirus-derived extracellular vesicles loaded with of γ-carboxylated Gla-rich protein: Dual modulation of inflammation and vascular calcification.,2026,10.1016/j.bioadv.2026.214833,https://pubmed.ncbi.nlm.nih.gov/41861711/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,40621007,&lt;i&gt;In Silico&lt;/i&gt; and &lt;i&gt;In Vitro&lt;/i&gt; Studies of Potential Novel Vitamin K Epoxide Reductase (VKOR) Inhibitors Suggest an Updated Structure-Activity Relationship.,2025,10.1021/acsomega.5c01116,https://pubmed.ncbi.nlm.nih.gov/40621007/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,34594221,Sex Metabolic Differences and Effects on Blood Coagulation Among Rats Exposed to Sodium Dehydroacetate.,2021,10.3389/fphar.2021.727084,https://pubmed.ncbi.nlm.nih.gov/34594221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,41050406,"Prevalence of risk phenotypes associated with &lt;i&gt;CYP2C9*2, *3,&lt;/i&gt; and &lt;i&gt;VKORC1 c.-1639G&gt;A&lt;/i&gt; genetic polymorphisms in world populations: implications in clinical practice.",2025,10.3389/fphar.2025.1597379,https://pubmed.ncbi.nlm.nih.gov/41050406/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42544696,The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin.,2026,10.1002/cpt.70413,https://pubmed.ncbi.nlm.nih.gov/42544696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,41465069,Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) Gene Polymorphisms Predict Arterial Stiffness and Serum MGP Levels in Chronic Kidney Disease Patients.,2025,10.3390/genes16121396,https://pubmed.ncbi.nlm.nih.gov/41465069/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42411791,"Ferulenol, a Prenylated Coumarin, Suppresses Collagen-Induced Platelet Activation via PLCγ2-Mediated cPLA2 Signaling in Humans.",2026,10.31083/pharmazie52496,https://pubmed.ncbi.nlm.nih.gov/42411791/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42841193,&lt;i&gt;CYP2C9&lt;/i&gt; and &lt;i&gt;VKORC1&lt;/i&gt; variants and warfarin response in Kazakh patients following cardiac surgery.,2026,10.1515/dmpt-2026-0030,https://pubmed.ncbi.nlm.nih.gov/42841193/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,41512386,Ginger (Zingiber officinale Roscoe)-derived natural compounds inhibit vitamin K-dependent carboxylation: a novel possibility for traditional Chinese medicine-induced bleeding risk.,2026,10.1016/j.phymed.2026.157777,https://pubmed.ncbi.nlm.nih.gov/41512386/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42630019,Pharmacogenomics in Dentistry: From CYP-Mediated Drug Response to Precision Prescribing in Oral Healthcare.,2026,10.1111/odi.70468,https://pubmed.ncbi.nlm.nih.gov/42630019/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42257367,Association between the &lt;i&gt;VKORC1&lt;/i&gt; rs8050894 CC genotype and undercarboxylated osteocalcin levels following vitamin K and D supplementation in Mexican Citizens with T2DM: A randomized clinical trial.,2026,10.1177/10815589261460882,https://pubmed.ncbi.nlm.nih.gov/42257367/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42756309,Vietnamese pharmacogenomic variation in global context: a systematic review and meta-analysis for clinical implementation.,2026,10.3389/fphar.2026.1921144,https://pubmed.ncbi.nlm.nih.gov/42756309/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,41728397,Clinical Pharmacogenomic Variants Among the Saudi Population and Their Impact on Drug Response: A Review of Saudi-Based Evidence.,2026,10.7759/cureus.101993,https://pubmed.ncbi.nlm.nih.gov/41728397/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,41656635,Clinical Application of Pharmacogenomics in Stroke Management: Current Evidence and Future Directions.,2026,10.5853/jos.2025.04595,https://pubmed.ncbi.nlm.nih.gov/41656635/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42703504,Prognostic value of genes associated with metastasis and propionate metabolism in rectal cancer.,2026,10.21037/jgo-2025-1-1061,https://pubmed.ncbi.nlm.nih.gov/42703504/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,41518981,Incidence of Vkorc1 gene mutations in brown rat (Rattus norvegicus) populations from downtown Madrid and their role in resistance to anticoagulant rodenticide: Implications for rodenticide management.,2026,10.1016/j.ecoenv.2026.119689,https://pubmed.ncbi.nlm.nih.gov/41518981/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,41155858,The Genetic Polymorphisms of CYP2C9 and VKORC1 in the Saudi Population and Their Impact on Anticoagulant Management.,2025,10.3390/medicina61101872,https://pubmed.ncbi.nlm.nih.gov/41155858/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,41892871,Explainable Artificial Intelligence Unravels the Possible Distinct Roles of VKORC1 and CYP2C9 in Predicting Warfarin Anticoagulation Control.,2026,10.3390/medsci14010156,https://pubmed.ncbi.nlm.nih.gov/41892871/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,41428972,Small-molecule inhibition of γ-glutamyl carboxylase reveals a novel anticoagulant strategy.,2026,10.1182/bloodadvances.2025018776,https://pubmed.ncbi.nlm.nih.gov/41428972/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,42168535,Pharmacogenomic landscape of a Moroccan cohort: enhancing global diversity and addressing the North African gap.,2026,10.1038/s41598-026-54350-1,https://pubmed.ncbi.nlm.nih.gov/42168535/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VKORC1,ENSG00000167397,Unsafe,14765194,Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.,2004,10.1038/nature02214,https://pubmed.ncbi.nlm.nih.gov/14765194/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,40746939,An antibody-drug conjugate targeting VpreB1 for the treatment of B-cell acute lymphoblastic leukemia.,2025,10.1016/j.bneo.2025.100120,https://pubmed.ncbi.nlm.nih.gov/40746939/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,42773776,Yishen Gushu Formula Attenuates Ovariectomy-Induced Bone Loss by Regulating the B-Cell Receptor Signaling Pathway in Rats.,2026,10.1177/15578100261489657,https://pubmed.ncbi.nlm.nih.gov/42773776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,41611721,Association-induced folding governs surrogate light chain and pre-B cell receptor core assembly.,2026,10.1038/s41467-026-68965-5,https://pubmed.ncbi.nlm.nih.gov/41611721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,39357526,Application of Gene Expression Microarray for the Classification of Ph-Like B-Cell Acute Lymphoblastic Leukemia.,2025,10.1111/ijlh.14370,https://pubmed.ncbi.nlm.nih.gov/39357526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,36311706,Evolution of surrogate light chain in tetrapods and the relationship between lengths of CDR H3 and VpreB tails.,2022,10.3389/fimmu.2022.1001134,https://pubmed.ncbi.nlm.nih.gov/36311706/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,41258531,Establishment and characterization of a novel cell line ICH-BCPALL-3 from B cell precursor acute lymphoblastic leukemia with TCF3::HLF.,2025,10.1007/s13577-025-01318-4,https://pubmed.ncbi.nlm.nih.gov/41258531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,40443574,Two case reports of B-cell lymphopenia associated with &lt;i&gt;IGLL1&lt;/i&gt; variants identified through newborn screening in Ukraine.,2025,10.3389/fped.2025.1566867,https://pubmed.ncbi.nlm.nih.gov/40443574/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,34662891,VpreB surrogate light chain expression in B-lineage ALL: a report from the Children's Oncology Group.,2022,10.1182/bloodadvances.2021005245,https://pubmed.ncbi.nlm.nih.gov/34662891/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,33418558,CRISPR/Cas9 mediated knock-out of VPREB1 gene induces a cytotoxic effect in myeloma cells.,2021,10.1371/journal.pone.0245349,https://pubmed.ncbi.nlm.nih.gov/33418558/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,39312877,Characterisation of cells markers associated with IKZF1&lt;sup&gt;plus&lt;/sup&gt; in BCP-ALL.,2024,10.1016/j.tranon.2024.102127,https://pubmed.ncbi.nlm.nih.gov/39312877/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,38752789,Comparative analysis of dynamic transcriptomes reveals specific COVID-19 features and pathogenesis of immunocompromised populations.,2024,10.1128/msystems.01385-23,https://pubmed.ncbi.nlm.nih.gov/38752789/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,33101545,Association of VPREB1 Gene Copy Number Variation and Rheumatoid Arthritis Susceptibility.,2020,10.1155/2020/7189626,https://pubmed.ncbi.nlm.nih.gov/33101545/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,40369607,Molecular characterization and predictors of relapse in patients with Ph + ALL after frontline ponatinib and blinatumomab.,2025,10.1186/s13045-025-01709-y,https://pubmed.ncbi.nlm.nih.gov/40369607/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,38777370,A multiomic characterization of the leukemia cell line REH using short- and long-read sequencing.,2024,10.26508/lsa.202302481,https://pubmed.ncbi.nlm.nih.gov/38777370/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,39453390,Construction of a five-gene-based prognostic model for relapsed/refractory acute lymphoblastic leukemia.,2024,10.1080/16078454.2024.2412952,https://pubmed.ncbi.nlm.nih.gov/39453390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,32218851,Complex karyotype with cryptic FUS gene rearrangement and deletion of NR3C1 and VPREB1 genes in childhood B-cell acute lymphoblastic leukemia: A case report.,2020,10.3892/ol.2020.11387,https://pubmed.ncbi.nlm.nih.gov/32218851/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,31291582,MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition.,2019,10.1016/j.celrep.2019.06.029,https://pubmed.ncbi.nlm.nih.gov/31291582/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,36980958,Optical Genome Mapping Reveals and Characterizes Recurrent Aberrations and New Fusion Genes in Adult ALL.,2023,10.3390/genes14030686,https://pubmed.ncbi.nlm.nih.gov/36980958/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,27611867,The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia.,2016,10.1371/journal.pone.0162638,https://pubmed.ncbi.nlm.nih.gov/27611867/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,34505882,Lymphoid blast transformation in an MPN with BCR-JAK2 treated with ruxolitinib: putative mechanisms of resistance.,2021,10.1182/bloodadvances.2020004174,https://pubmed.ncbi.nlm.nih.gov/34505882/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,35395988,[Bioinformatics Analysis of Microarray Data in Myelodysplastic Syndrome Based on Gene Expression Omnibus Database].,2022,10.19746/j.cnki.issn.1009-2137.2022.02.031,https://pubmed.ncbi.nlm.nih.gov/35395988/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,22684248,"A VpreB3 homologue in a marsupial, the gray short-tailed opossum, Monodelphis domestica.",2012,10.1007/s00251-012-0626-0,https://pubmed.ncbi.nlm.nih.gov/22684248/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,28217764,VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen-binding sites.,2016,10.1126/sciimmunol.aaf6628,https://pubmed.ncbi.nlm.nih.gov/28217764/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,34410295,Association of Combined Focal 22q11.22 Deletion and IKZF1 Alterations With Outcomes in Childhood Acute Lymphoblastic Leukemia.,2021,10.1001/jamaoncol.2021.2723,https://pubmed.ncbi.nlm.nih.gov/34410295/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,34113352,"Dermatan Sulfate Is a Potential Regulator of IgH via Interactions With Pre-BCR, GTF2I, and BiP ER Complex in Pre-B Lymphoblasts.",2021,10.3389/fimmu.2021.680212,https://pubmed.ncbi.nlm.nih.gov/34113352/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,27799525,Expression of HIV-1 matrix protein p17 and association with B-cell lymphoma in HIV-1 transgenic mice.,2016,10.1073/pnas.1615258113,https://pubmed.ncbi.nlm.nih.gov/27799525/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,16281060,The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription.,2005,10.1038/sj.emboj.7600850,https://pubmed.ncbi.nlm.nih.gov/16281060/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,29472919,"In the Absence of Central pre-B Cell Receptor Selection, Peripheral Selection Attempts to Optimize the Antibody Repertoire by Enriching for CDR-H3 Y101.",2018,10.3389/fimmu.2018.00120,https://pubmed.ncbi.nlm.nih.gov/29472919/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPREB1,ENSG00000169575,Unsafe,11181696,Loss of precursor B cell expansion but not allelic exclusion in VpreB1/VpreB2 double-deficient mice.,2001,10.1084/jem.193.4.435,https://pubmed.ncbi.nlm.nih.gov/11181696/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,42537404,VPS33A and VPS18 orchestrate porcine epidemic diarrhea virus replication by modulating autophagic flux.,2026,10.1080/21505594.2026.2707880,https://pubmed.ncbi.nlm.nih.gov/42537404/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,41718964,VPS33A Promotes Pemigatinib Resistance in Cholangiocarcinoma via Autophagy.,2026,10.1007/s10620-026-09720-0,https://pubmed.ncbi.nlm.nih.gov/41718964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,40822349,Triclabendazole suppresses cellular levels of glycosaminoglycan-A potential therapeutic agent for mucopolysaccharidoses and related diseases.,2025,10.1016/j.isci.2025.113118,https://pubmed.ncbi.nlm.nih.gov/40822349/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,41310305,The use of genistein and ambroxol may be an effective approach in correcting cellular dysfunctions of mucopolysaccharidosis-plus syndrome.,2025,10.1007/s00335-025-10176-2,https://pubmed.ncbi.nlm.nih.gov/41310305/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,41154677,"Mucopolysaccharidoses-What Clinicians Need to Know: A Clinical, Biochemical, and Molecular Overview.",2025,10.3390/biom15101448,https://pubmed.ncbi.nlm.nih.gov/41154677/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,42584803,Identification and Validation of programmed cell death-related biomarkers in Osteoarthritis and an Exploratory Pan-Cancer Analysis: SHARPIN as a Potential Biomarker.,2026,10.1007/s10067-026-08320-7,https://pubmed.ncbi.nlm.nih.gov/42584803/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,42691780,Clinical and biochemical footprints of inherited disorders of autophagy.,2026,10.1016/j.ymgme.2026.110248,https://pubmed.ncbi.nlm.nih.gov/42691780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,40758165,Cellular and molecular changes in mucopolysaccharidosis-plus syndrome caused by a homozygous c.599G &gt; C (p.Arg200Pro) variant of the VPS33A gene.,2026,10.1007/s13353-025-00997-x,https://pubmed.ncbi.nlm.nih.gov/40758165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,39273517,Mucopolysaccharidosis-Plus Syndrome: Is This a Type of Mucopolysaccharidosis or a Separate Kind of Metabolic Disease?,2024,10.3390/ijms25179570,https://pubmed.ncbi.nlm.nih.gov/39273517/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,41977248,Autophagy-Mitophagy Pathway-Linked Genetic Variants Associate with Systemic Inflammation and Interact with Dietary Factors in Asian and European Cohorts.,2026,10.3390/ijms27073062,https://pubmed.ncbi.nlm.nih.gov/41977248/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,38585203,Domain 3a mutation of VPS33A suppresses larval arrest phenotype in the loss of VPS45 in Caenorhabditis elegans.,2024,10.17912/micropub.biology.001155,https://pubmed.ncbi.nlm.nih.gov/38585203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,36153662,Juvenile mucopolysaccharidosis plus disease caused by a missense mutation in VPS33A.,2022,10.1002/humu.24479,https://pubmed.ncbi.nlm.nih.gov/36153662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,36232726,Mucopolysaccharidosis-Plus Syndrome: Report on a Polish Patient with a Novel VPS33A Variant with Comparison with Other Described Patients.,2022,10.3390/ijms231911424,https://pubmed.ncbi.nlm.nih.gov/36232726/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,33938619,Bi-allelic VPS16 variants limit HOPS/CORVET levels and cause a mucopolysaccharidosis-like disease.,2021,10.15252/emmm.202013376,https://pubmed.ncbi.nlm.nih.gov/33938619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,31070736,The lysosomal disease caused by mutant VPS33A.,2019,10.1093/hmg/ddz077,https://pubmed.ncbi.nlm.nih.gov/31070736/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,34285335,Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue.,2021,10.1038/s12276-021-00648-1,https://pubmed.ncbi.nlm.nih.gov/34285335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,35327996,"Mucopolysaccharidosis-Plus Syndrome, a Rapidly Progressive Disease: Favorable Impact of a Very Prolonged Steroid Treatment on the Clinical Course in a Child.",2022,10.3390/genes13030442,https://pubmed.ncbi.nlm.nih.gov/35327996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,37062417,The Sec1-Munc18 protein VPS33B forms a uniquely bidirectional complex with VPS16B.,2023,10.1016/j.jbc.2023.104718,https://pubmed.ncbi.nlm.nih.gov/37062417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,33764426,Bi-allelic variants in HOPS complex subunit VPS41 cause cerebellar ataxia and abnormal membrane trafficking.,2021,10.1093/brain/awaa459,https://pubmed.ncbi.nlm.nih.gov/33764426/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,37628632,Prenatal Diagnosis of Mucopolysaccharidosis-Plus Syndrome (MPSPS).,2023,10.3390/genes14081581,https://pubmed.ncbi.nlm.nih.gov/37628632/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,35905627,Triphenyltin exposure induced abnormal morphological colouration in adult male guppies (Poecilia reticulata).,2022,10.1016/j.ecoenv.2022.113912,https://pubmed.ncbi.nlm.nih.gov/35905627/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,30898038,Elevated pulmonary tuberculosis biomarker miR-423-5p plays critical role in the occurrence of active TB by inhibiting autophagosome-lysosome fusion.,2019,10.1080/22221751.2019.1590129,https://pubmed.ncbi.nlm.nih.gov/30898038/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,31188703,A reversible autophagy inhibitor blocks autophagosome-lysosome fusion by preventing Stx17 loading onto autophagosomes.,2019,10.1091/mbc.e18-08-0482,https://pubmed.ncbi.nlm.nih.gov/31188703/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,19158398,The SM protein Car/Vps33A regulates SNARE-mediated trafficking to lysosomes and lysosome-related organelles.,2009,10.1091/mbc.e08-03-0282,https://pubmed.ncbi.nlm.nih.gov/19158398/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,29608557,"A high throughput, functional screen of human Body Mass Index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses.",2018,10.1371/journal.pgen.1007222,https://pubmed.ncbi.nlm.nih.gov/29608557/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VPS33A,ENSG00000139719,Unsafe,22203954,Targeting protein-trafficking pathways alters melanoma treatment sensitivity.,2012,10.1073/pnas.1118366109,https://pubmed.ncbi.nlm.nih.gov/22203954/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,41827800,Beyond Gastric Specificity: V-Set and Immunoglobulin Domain-Containing 1 (VSIG1) in Digestive Tract Tumors.,2026,10.3390/cancers18050867,https://pubmed.ncbi.nlm.nih.gov/41827800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,38928294,Gastric-Type Expression Signature in Hepatocellular Carcinoma.,2024,10.3390/ijms25126588,https://pubmed.ncbi.nlm.nih.gov/38928294/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,37587724,Downregulation of cancer-associated fibroblast exosome-derived miR-29b-1-5p restrains vasculogenic mimicry and apoptosis while accelerating migration and invasion of gastric cancer cells via immunoglobulin domain-containing 1/zonula occluden-1 axis.,2023,10.1080/15384101.2023.2231740,https://pubmed.ncbi.nlm.nih.gov/37587724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,36171238,V-set and immunoglobulin domain containing 1 (VSIG1) as an emerging target for epithelial-mesenchymal transition of gastric cancer.,2022,10.1038/s41598-022-19883-1,https://pubmed.ncbi.nlm.nih.gov/36171238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,38570609,Convergent gene losses and pseudogenizations in multiple lineages of stomachless fishes.,2024,10.1038/s42003-024-06103-x,https://pubmed.ncbi.nlm.nih.gov/38570609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,40843895,Evolution of the Jawed Vertebrate (Gnathostomata) Stomach Through Gene Repertoire Loss: Findings from Agastric Species.,2025,10.3390/jdb13030027,https://pubmed.ncbi.nlm.nih.gov/40843895/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,37240039,Mucin-Phenotype and Expression of the Protein V-Set and Immunoglobulin Domain Containing 1 (VSIG1): New Insights into Gastric Carcinogenesis.,2023,10.3390/ijms24108697,https://pubmed.ncbi.nlm.nih.gov/37240039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,33916888,"V-Set and Immunoglobulin Domain-Containing 1 (VSIG1), Predominantly Expressed in Testicular Germ Cells, Is Dispensable for Spermatogenesis and Male Fertility in Mice.",2021,10.3390/ani11041037,https://pubmed.ncbi.nlm.nih.gov/33916888/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,40207165,"Isolation, phylogenetics, and characterization of a new PDCoV strain that affects cellular gene expression in human cells.",2025,10.3389/fmicb.2025.1534907,https://pubmed.ncbi.nlm.nih.gov/40207165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,42544649,[Establishment of a Doxorubicin-Resistant Acute Myeloid Leukemia Cell Line and Study on Its Drug Resistance Mechanisms].,2026,10.19746/j.cnki.issn1009-2137.2026.03.004,https://pubmed.ncbi.nlm.nih.gov/42544649/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,40897077,Functional stomach loss preceding body inflation evolution in Tetraodontiformes: Evidence of gene loss and rapid evolution.,2025,10.1016/j.cbd.2025.101574,https://pubmed.ncbi.nlm.nih.gov/40897077/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,34170400,"Interaction between cadherins, vimentin, and V-set and immunoglobulin domain containing 1 in gastric-type hepatocellular carcinoma.",2021,10.1007/s00418-021-02006-8,https://pubmed.ncbi.nlm.nih.gov/34170400/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,37544131,HPV disrupt the cytoskeleton in oral squamous cell carcinomas from non-oropharyngeal sites via the E-cadherin/Mena/SMA pathway.,2023,10.1016/j.prp.2023.154723,https://pubmed.ncbi.nlm.nih.gov/37544131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,40199101,The surface proteome of rabbit spermatozoa.,2025,10.1016/j.anireprosci.2025.107834,https://pubmed.ncbi.nlm.nih.gov/40199101/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,28603843,"Characterization of V-set and immunoglobulin domain containing 1 exerting a tumor suppressor function in gastric, lung, and esophageal cancer cells.",2017,10.1111/cas.13295,https://pubmed.ncbi.nlm.nih.gov/28603843/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,33423702,"An ""expressionistic"" look at serrated precancerous colorectal lesions.",2021,10.1186/s13000-020-01064-1,https://pubmed.ncbi.nlm.nih.gov/33423702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,33176137,Functional Pro-metastatic Heterogeneity Revealed by Spiked-scRNAseq Is Shaped by Cancer Cell Interactions and Restricted by VSIG1.,2020,10.1016/j.celrep.2020.108372,https://pubmed.ncbi.nlm.nih.gov/33176137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,32403160,High expression of CXCL14 is a biomarker of lung adenocarcinoma with micropapillary pattern.,2020,10.1111/cas.14456,https://pubmed.ncbi.nlm.nih.gov/32403160/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,29204252,"Paradoxical expression pattern of the epithelial mesenchymal transition-related biomarkers CD44, SLUG, N-cadherin and VSIG1/Glycoprotein A34 in gastrointestinal stromal tumors.",2017,10.4251/wjgo.v9.i11.436,https://pubmed.ncbi.nlm.nih.gov/29204252/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,21991385,Adhesion protein VSIG1 is required for the proper differentiation of glandular gastric epithelia.,2011,10.1371/journal.pone.0025908,https://pubmed.ncbi.nlm.nih.gov/21991385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VSIG1,ENSG00000101842,Unsafe,16405301,"Glycoprotein A34, a novel target for antibody-based cancer immunotherapy.",2006,,https://pubmed.ncbi.nlm.nih.gov/16405301/,annotation citations | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VWA3B,ENSG00000168658,Unsafe,41673450,Childhood-onset ataxia with dystonia: expanding the spectrum of VWA3B-related disorders.,2026,10.1038/s10038-026-01460-3,https://pubmed.ncbi.nlm.nih.gov/41673450/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VWA3B,ENSG00000168658,Unsafe,40746421,Proteomic and structural comparison between cilia from primary ciliary dyskinesia patients with a DNAH5 defect.,2025,10.3389/fmolb.2025.1593810,https://pubmed.ncbi.nlm.nih.gov/40746421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VWA3B,ENSG00000168658,Unsafe,39199980,Genome-Wide Analysis of Genetic Diversity and Selection Signatures in Zaobei Beef Cattle.,2024,10.3390/ani14162447,https://pubmed.ncbi.nlm.nih.gov/39199980/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VWA3B,ENSG00000168658,Unsafe,40630915,Transcriptomic profiling and bioinformatic insights into myocardial injury following aneurysmal subarachnoid hemorrhage.,2025,10.3389/fneur.2025.1492398,https://pubmed.ncbi.nlm.nih.gov/40630915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VWA3B,ENSG00000168658,Unsafe,39442698,Methylome-wide association study of adolescent depressive episode with psychotic symptoms and childhood trauma.,2025,10.1016/j.jad.2024.10.029,https://pubmed.ncbi.nlm.nih.gov/39442698/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VWA3B,ENSG00000168658,Unsafe,37772257,Identification of genetic variants associated with a wide spectrum of phenotypes clinically diagnosed as Sanfilippo and Morquio syndromes using whole genome sequencing.,2023,10.3389/fgene.2023.1254909,https://pubmed.ncbi.nlm.nih.gov/37772257/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VWA3B,ENSG00000168658,Unsafe,26157035,A homozygous mutation of VWA3B causes cerebellar ataxia with intellectual disability.,2016,10.1136/jnnp-2014-309828,https://pubmed.ncbi.nlm.nih.gov/26157035/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
VWA3B,ENSG00000168658,Unsafe,34417961,Preliminary study of genome-wide association identifies novel susceptibility genes for serum mineral elements in the Chinese Han population.,2022,10.1007/s12011-021-02854-4,https://pubmed.ncbi.nlm.nih.gov/34417961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,41685452,Elevated Pulmonary Artery Wedge Pressure in Group 1 Pulmonary Hypertension.,2026,10.1161/circulationaha.125.077606,https://pubmed.ncbi.nlm.nih.gov/41685452/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,42460063,Case Report: Pulmonary artery biopsy findings in a patient with a BMPR2 variant-associated pulmonary arterial hypertension.,2026,10.3389/fmed.2026.1848607,https://pubmed.ncbi.nlm.nih.gov/42460063/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,42026897,Right Atrial Pressure/Pulmonary Artery Wedge Pressure Ratio Correlates With Early Outcomes After Pulmonary Endarterectomy for Chronic Thromboembolic Pulmonary Hypertension.,2026,10.1002/resp.70255,https://pubmed.ncbi.nlm.nih.gov/42026897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,42057615,Right heart catheterization blended training program: quality improvement and educational outcomes.,2026,10.1093/atsscholar/aapag022,https://pubmed.ncbi.nlm.nih.gov/42057615/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,41073129,Phenotyping of patients with mild pulmonary hypertension.,2025,10.1136/openhrt-2025-003591,https://pubmed.ncbi.nlm.nih.gov/41073129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,41465363,Knockdown-Induced Fasting Phenotypes in Flatworms: Insights into Underlying Mechanisms of Feeding Behavior.,2025,10.3390/ijms262411934,https://pubmed.ncbi.nlm.nih.gov/41465363/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,42325947,Machine learning for prediction of key haemodynamic parameters in pulmonary arterial hypertension.,2026,10.1093/ehjdh/ztaf074,https://pubmed.ncbi.nlm.nih.gov/42325947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,41115606,Impact of Elevated Pulmonary Arterial Wedge Pressure on Safety and Efficacy of Balloon Pulmonary Angioplasty in the Treatment of Chronic Thromboembolic Pulmonary Hypertension.,2026,10.1016/j.chest.2025.10.017,https://pubmed.ncbi.nlm.nih.gov/41115606/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,42569061,Right Ventricular to Left Ventricular (RV/LV) Blood Pool T2 Ratio Is Associated With Invasive Hemodynamics Across Pulmonary Hypertension Subgroups.,2026,10.1002/pul2.70381,https://pubmed.ncbi.nlm.nih.gov/42569061/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,40767090,The fluid challenge for identification of pulmonary hypertension associated with left heart disease.,2025,10.1097/mcp.0000000000001189,https://pubmed.ncbi.nlm.nih.gov/40767090/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,39768504,Reassessing Pulmonary Hypertension Classification: Utilizing Criteria for Heart Failure with Preserved Ejection Fraction Instead of Pulmonary Arterial Wedge Pressure.,2024,10.3390/jcm13247582,https://pubmed.ncbi.nlm.nih.gov/39768504/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,39209475,"Definition, classification and diagnosis of pulmonary hypertension.",2024,10.1183/13993003.01324-2024,https://pubmed.ncbi.nlm.nih.gov/39209475/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,41467934,Concomitant Effect of Hypothyroidism with Obesity on Testicular and Sperm Function in Male ICR Mice: Involvement of TGFβ/SMAD Signaling.,2026,10.1007/s12013-025-01973-2,https://pubmed.ncbi.nlm.nih.gov/41467934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,42368181,Incidence of Adverse Cardiac Events After Liver Transplantation in Patients With Different Hemodynamic Classifications of Pulmonary Hypertension.,2026,10.1155/ijh/2869285,https://pubmed.ncbi.nlm.nih.gov/42368181/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,41081177,Correlation between the extracellular volume fraction and hemodynamic parameters in light-chain cardiac amyloidosis patients.,2025,10.21037/qims-24-2243,https://pubmed.ncbi.nlm.nih.gov/41081177/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,38628496,"PLCζ, WBP2NL and TNF-α expression in spermatozoa is associated with stallion fertility and seminal quality?",2024,10.1590/1984-3143-ar2023-0088,https://pubmed.ncbi.nlm.nih.gov/38628496/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,39567192,The relationship between mixed venous blood oxygen saturation and pulmonary arterial and venous pressures in patients with heart failure.,2024,10.14814/phy2.70128,https://pubmed.ncbi.nlm.nih.gov/39567192/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,42288249,Impact of Systemic-to-Pulmonary Artery Shunt Embolization on Right Heart Hemodynamics in Patients with Bronchiectasis.,2026,10.1016/j.jvir.2026.108903,https://pubmed.ncbi.nlm.nih.gov/42288249/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,40446883,Prevalence of occult HFpEF and age-specific efficacy of passive leg raise in pulmonary hypertension.,2025,10.1016/j.healun.2025.04.020,https://pubmed.ncbi.nlm.nih.gov/40446883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,41052526,[Definition and Classification of Pulmonary Hypertension].,2025,10.1055/a-2625-4769,https://pubmed.ncbi.nlm.nih.gov/41052526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,41835997,Pulmonary artery denervation improves left ventricular diastolic function in patients with isolated post-capillary pulmonary hypertension secondary to heart failure with preserved ejection fraction: a safety and proof-of-principle cohort study.,2026,10.4244/aij-d-25-00061,https://pubmed.ncbi.nlm.nih.gov/41835997/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,41800501,A comprehensive review about sperm-oocyte interactions and key activation factors of fertilization in mammals.,2026,10.32604/cju.2025.069420,https://pubmed.ncbi.nlm.nih.gov/41800501/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,41653169,"Ambrisentan for Early-Stage Low-Risk Pulmonary Arterial Hypertension: Design of the Randomized, Double-Blind, Placebo-Controlled ALEPH Trial.",2026,10.1016/j.jacasi.2025.12.014,https://pubmed.ncbi.nlm.nih.gov/41653169/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,41888869,Update on pulmonary hypertension.,2026,10.1186/s12931-026-03635-0,https://pubmed.ncbi.nlm.nih.gov/41888869/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,40981641,"Hemodynamic Ramp Test in Cardiogenic Shock Supported by Microaxial Flow Pump: Protocol Description, Feasibility, and Hemodynamic Response.",2026,10.1097/mat.0000000000002555,https://pubmed.ncbi.nlm.nih.gov/40981641/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,42512605,Comparison of Functional and Hemodynamic Parameters Between Methamphetamine-Associated and Idiopathic Pulmonary Arterial Hypertension: Systematic Review and Meta-Analysis.,2026,10.3390/healthcare14142089,https://pubmed.ncbi.nlm.nih.gov/42512605/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,41613828,Sotatercept in Pulmonary Langerhans Cell Histiocytosis-Associated Pulmonary Hypertension: A Case Series and Systematic Review.,2026,10.1002/pul2.70239,https://pubmed.ncbi.nlm.nih.gov/41613828/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,41822894,Hemodynamic effects of cycle ergometry and low-intensity handgrip in patients with pulmonary hypertension.,2026,10.3389/fmed.2026.1727173,https://pubmed.ncbi.nlm.nih.gov/41822894/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,41393960,Rethinking Operability in Large VSD: The Diastolic Pulmonary Shunt Index (DiPSI) and a Probabilistic Perspective.,2025,10.1002/pul2.70225,https://pubmed.ncbi.nlm.nih.gov/41393960/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,39957705,Meta-Analysis of Real-World Clinical Practice to Assess the Effectiveness of Riociguat in Treating Chronic Thromboembolic Pulmonary Hypertension.,2025,10.1111/jch.70015,https://pubmed.ncbi.nlm.nih.gov/39957705/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,37753275,Pulmonary arterial wedge pressure increase during exercise in patients diagnosed with pulmonary arterial or chronic thromboembolic pulmonary hypertension.,2023,10.1183/23120541.00379-2023,https://pubmed.ncbi.nlm.nih.gov/37753275/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,39991489,Comparative hemodynamic responses to upright and recumbent cycling in patients with exercise intolerance.,2024,10.3389/fcvm.2024.1431787,https://pubmed.ncbi.nlm.nih.gov/39991489/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WBP2NL,ENSG00000183066,Unsafe,17289678,"PAWP, a sperm-specific WW domain-binding protein, promotes meiotic resumption and pronuclear development during fertilization.",2007,10.1074/jbc.m609132200,https://pubmed.ncbi.nlm.nih.gov/17289678/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,42393565,Integrated bioinformatic multi-omics analysis and experimental verification reveal the oncogenic role of WDHD1 and its underlying mechanism in gastric cancer progression.,2026,10.1186/s12885-026-16401-8,https://pubmed.ncbi.nlm.nih.gov/42393565/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,41850053,WDHD1 promotes hepatocellular carcinoma progression by affecting the cell cycle and immune evasion.,2026,10.1016/j.tranon.2026.102735,https://pubmed.ncbi.nlm.nih.gov/41850053/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,41962535,Bi-allelic WDHD1 variants cause microcephalic primordial dwarfism.,2026,10.1016/j.ajhg.2026.03.010,https://pubmed.ncbi.nlm.nih.gov/41962535/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,42041705,E2F1-Driven WDHD1 Transcription Enhances Cell-Cycle Progression and Promotes Pancreatic Cancer Progression.,2026,10.3390/curroncol33040186,https://pubmed.ncbi.nlm.nih.gov/42041705/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,41291744,Activation of WDHD1 by DNA demethylases promotes MINPP1 transcription and glycolysis in lung adenocarcinoma progression.,2025,10.1186/s12931-025-03399-z,https://pubmed.ncbi.nlm.nih.gov/41291744/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,41885168,An essential role for actinotrichia in zebrafish fin patterning and courtship behavior.,2026,10.1242/dev.204990,https://pubmed.ncbi.nlm.nih.gov/41885168/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,41902797,A Tumor Microenvironment-Derived CAF-VEGF Model and Its Application in Biomarker Screening for HCC.,2026,10.1002/cbf.70204,https://pubmed.ncbi.nlm.nih.gov/41902797/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,40711991,Previously undescribed effects and mechanisms of STAT3 in HPV-induced DNA re-replication in response to DNA damage.,2025,10.1111/febs.70201,https://pubmed.ncbi.nlm.nih.gov/40711991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,41063234,Interaction between IGF2BP3 and RP11-480I12.5 facilitates proliferation and suppresses apoptosis in non-small cell lung cancer.,2025,10.1186/s40001-025-03193-z,https://pubmed.ncbi.nlm.nih.gov/41063234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,37759234,"Integrative bioinformatics analysis of WDHD1: a potential biomarker for pan-cancer prognosis, diagnosis, and immunotherapy.",2023,10.1186/s12957-023-03187-3,https://pubmed.ncbi.nlm.nih.gov/37759234/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,38980253,An immune biomarker associated with EMT serves as a predictor for prognosis and drug response in bladder cancer.,2024,10.18632/aging.205927,https://pubmed.ncbi.nlm.nih.gov/38980253/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,40752182,Transcriptomic analysis unveils critical genes governing early development and sex differentiation in the Cipangopaludina chinensis (Gastropoda: Viviparidae).,2025,10.1016/j.cbd.2025.101590,https://pubmed.ncbi.nlm.nih.gov/40752182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,40021097,Exploring the novel role and mechanistic insights of skeletal muscle relaxant cyclobenzaprine hydrochloride in esophageal squamous cell carcinoma treatment.,2025,10.1016/j.ejps.2025.107051,https://pubmed.ncbi.nlm.nih.gov/40021097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,40516835,Bioinformatics and experiments reveal the hub genes of age-related hearing loss and the mechanism of PLK1 silencing in the protection of aging cochlear hair cells.,2025,10.1016/j.gene.2025.149632,https://pubmed.ncbi.nlm.nih.gov/40516835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,40898188,Integrating proteomics and bioinformatics for the identification of breast cancer biomarkers interacting with telomeric G-quadruplex.,2025,10.1186/s12935-025-03955-z,https://pubmed.ncbi.nlm.nih.gov/40898188/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,39072709,"Design, synthesis, and evaluation of novel stilbene derivatives that degrade acidic nucleoplasmic DNA-binding protein 1 (And1) and synergize with PARP1 inhibitor in NSCLC cells.",2024,10.1080/14756366.2024.2383886,https://pubmed.ncbi.nlm.nih.gov/39072709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,39935706,Decoding oral cancer: insights from miRNA expression profiles and their regulatory targets.,2024,10.3389/fmolb.2024.1521839,https://pubmed.ncbi.nlm.nih.gov/39935706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,37569867,WD Repeat and HMG Box DNA Binding Protein 1: An Oncoprotein at the Hub of Tumorigenesis and a Novel Therapeutic Target.,2023,10.3390/ijms241512494,https://pubmed.ncbi.nlm.nih.gov/37569867/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,36345604,WDHD1 is over-expressed in nasopharyngeal carcinoma and may control the expression of ITGAV.,2023,10.1002/2211-5463.13519,https://pubmed.ncbi.nlm.nih.gov/36345604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,37323410,Exploring Key Genes with Diagnostic Value for Nonalcoholic Steatohepatitis Based on Bioinformatics Analysis.,2023,10.1021/acsomega.3c01709,https://pubmed.ncbi.nlm.nih.gov/37323410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,41832834,Itaconic acid additives reconstruct the solvation structure and stabilize the anode interface of aqueous zinc-ion batteries.,2026,10.1016/j.jcis.2026.140285,https://pubmed.ncbi.nlm.nih.gov/41832834/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,41367976,Predictive Validity of the e-Connect Suicide Risk Classification Algorithm in Youth on Probation.,2025,10.1016/j.jaacop.2025.04.006,https://pubmed.ncbi.nlm.nih.gov/41367976/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,35422862,The Involvement of WDHD1 in the Occurrence of Esophageal Cancer as a Downstream Target of PI3K/AKT Pathway.,2022,10.1155/2022/5871188,https://pubmed.ncbi.nlm.nih.gov/35422862/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,37059208,The association between internal polycyclic aromatic hydrocarbons exposure and risk of Obesity-A systematic review with meta-analysis.,2023,10.1016/j.chemosphere.2023.138669,https://pubmed.ncbi.nlm.nih.gov/37059208/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,32426268,WDHD1 Leads to Cisplatin Resistance by Promoting MAPRE2 Ubiquitination in Lung Adenocarcinoma.,2020,10.3389/fonc.2020.00461,https://pubmed.ncbi.nlm.nih.gov/32426268/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,33221821,WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer.,2020,10.1038/s41419-020-03210-5,https://pubmed.ncbi.nlm.nih.gov/33221821/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,37844410,Transcriptomic profiling of TLR-7-mediated immune-challenge in zebrafish embryos in the presence and absence of glucocorticoid-induced immunosuppression.,2023,10.1016/j.ecoenv.2023.115570,https://pubmed.ncbi.nlm.nih.gov/37844410/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,35732289,Effectiveness and safety of ultrasound-guided high-intensity focused ultrasound ablation for the treatment of colorectal cancer liver metastases.,2022,10.1080/02656736.2022.2086712,https://pubmed.ncbi.nlm.nih.gov/35732289/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,36794538,Association of serum albumin to globulin ratio with outcomes in acute ischemic stroke.,2023,10.1111/cns.14108,https://pubmed.ncbi.nlm.nih.gov/36794538/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,36245565,Bacteriological Quality of Table Eggs in Moroccan Formal and Informal Sector.,2022,10.1155/2022/6223404,https://pubmed.ncbi.nlm.nih.gov/36245565/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,32882197,Outcomes of Ambulatory Axillary Intraaortic Balloon Pump as a Bridge to Heart Transplantation.,2021,10.1016/j.athoracsur.2020.06.077,https://pubmed.ncbi.nlm.nih.gov/32882197/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDHD1,ENSG00000198554,Unsafe,27171113,Impact of Androstenone on Leash Pulling and Jumping Up in Dogs.,2016,10.3390/ani6050034,https://pubmed.ncbi.nlm.nih.gov/27171113/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,41268724,Identification of conserved residues essential for the ciliogenic functions of WDPCP.,2025,10.1242/dmm.052149,https://pubmed.ncbi.nlm.nih.gov/41268724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,42454909,mSphere Legacy: Fritz about Fritz.,2026,10.1128/msphere.00361-26,https://pubmed.ncbi.nlm.nih.gov/42454909/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,39582775,High gestational leucine level dampens WDPCP/MAPK signaling to impair the EMT and migration of cardiac microvascular endothelial cells in congenital heart defects.,2024,10.1002/pul2.70013,https://pubmed.ncbi.nlm.nih.gov/39582775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,42390542,Young Investigator Award 2026: Integrative mechanistic insights into YAP/TAZ-mediated angiogenesis and its therapeutic implications.,2026,10.1007/s00210-026-05654-6,https://pubmed.ncbi.nlm.nih.gov/42390542/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,42193919,Rebuilding the Mucociliary Apparatus in ECRS: TSLP/IL-33 Signaling Synergy and the Residual Molecular Scar of &lt;i&gt;DNASE1L3&lt;/i&gt; Following IL-4/13 Blockade.,2026,10.3390/cells15100911,https://pubmed.ncbi.nlm.nih.gov/42193919/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,42409159,Coherent photonic biofields: Revisiting Fritz-Albert Popp's hypothesis.,2026,10.1016/j.biosystems.2026.105880,https://pubmed.ncbi.nlm.nih.gov/42409159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,40172470,Fritz Köberle: A Life Dedicated to Medicine.,2025,10.1590/0037-8682-0045-2025,https://pubmed.ncbi.nlm.nih.gov/40172470/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,41797961,Points to Remember in Ovarian Eponyms Pearls: Dr. Fritz Malignant Brenner Tumor.,2026,10.4103/gmit.gmit-d-25-00042,https://pubmed.ncbi.nlm.nih.gov/41797961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,39669798,A cross-tissue transcriptome-wide association study identifies WDPCP as a potential susceptibility gene for coronary atherosclerosis.,2024,10.1016/j.athplu.2024.11.002,https://pubmed.ncbi.nlm.nih.gov/39669798/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,37996473,"Evidence for involvement of the alcohol consumption WDPCP gene in lipid metabolism, and liver cirrhosis.",2023,10.1038/s41598-023-47371-7,https://pubmed.ncbi.nlm.nih.gov/37996473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,41247789,Causal associations between human plasma proteins and prostate cancer identified by proteome-wide Mendelian randomization.,2025,10.7554/elife.101584,https://pubmed.ncbi.nlm.nih.gov/41247789/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,41188790,Cross-tissue transcriptome-wide association studies identify genetic susceptibility genes for prostate cancer.,2025,10.1186/s12885-025-14827-0,https://pubmed.ncbi.nlm.nih.gov/41188790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,40470020,The rediscovery of Fritz Heider's early social cognition: a person-centered perspective.,2025,10.3389/fpsyg.2025.1577720,https://pubmed.ncbi.nlm.nih.gov/40470020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,40927956,Randomised Clinical Trial on the Effect of Intermittent Vibrational Force Application During Orthodontic Treatment With Aligners on Root Resorption.,2025,10.1111/ocr.70028,https://pubmed.ncbi.nlm.nih.gov/40927956/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,40398431,The Rise of Stereotactic Neurosurgery in Germany.,2025,10.1055/a-2558-3307,https://pubmed.ncbi.nlm.nih.gov/40398431/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,42197345,Biofilm Formation and Plastic Degradation in Bacteria from Different Environments: Evidence for Phenotypic Acclimation and Metabolic Exaptation.,2026,10.3390/microorganisms14050959,https://pubmed.ncbi.nlm.nih.gov/42197345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,39710986,Fritz Kauffmann: innovator in microbial classification.,2025,10.1111/apm.13504,https://pubmed.ncbi.nlm.nih.gov/39710986/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,42359970,"The 1965 ""Gloria Films,"" Then and Now.",2026,10.1002/jhbs.70062,https://pubmed.ncbi.nlm.nih.gov/42359970/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,41204708,scRNA-Seq Reveals Sustained Pro-Inflammation by Innate Immune Activation in In Utero HBV-Exposed Neonates of High HBsAg Mothers.,2025,10.1111/liv.70405,https://pubmed.ncbi.nlm.nih.gov/41204708/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,34225660,Wdpcp regulates cellular proliferation and differentiation in the developing limb via hedgehog signaling.,2021,10.1186/s12861-021-00241-9,https://pubmed.ncbi.nlm.nih.gov/34225660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,40829216,"Management of caffeine in wastewater using nanolayered material: An integrated study of process kinetics, modeling, and toxicity assessment.",2025,10.1016/j.jenvman.2025.127011,https://pubmed.ncbi.nlm.nih.gov/40829216/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,40705409,"Telehealth for the Initial Evaluation of Musculoskeletal Disorders: Qualitative Study of Patients, Health Care Providers, and Key Stakeholders in the Province of Quebec in Canada.",2025,10.2196/72901,https://pubmed.ncbi.nlm.nih.gov/40705409/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,40253419,A comparison between adsorption and photocatalytic degradation for the management of sulfamethoxazole in water.,2025,10.1038/s41598-025-95947-2,https://pubmed.ncbi.nlm.nih.gov/40253419/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,40627018,First Report of &lt;i&gt;Polystigma amygdalinum&lt;/i&gt; Causing Red Leaf Blotch of Almond in California.,2025,10.1094/pdis-04-25-0925-pdn,https://pubmed.ncbi.nlm.nih.gov/40627018/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,35879774,"Dendrimer-based drug delivery systems: history, challenges, and latest developments.",2022,10.1186/s13036-022-00298-5,https://pubmed.ncbi.nlm.nih.gov/35879774/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,34200559,A Multi-Rheology Design Method of Sheeting Polymer Extrusion Dies Based on Flow Network and the Winter-Fritz Design Equation.,2021,10.3390/polym13121924,https://pubmed.ncbi.nlm.nih.gov/34200559/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,35772733,Signaling Role of NADPH Oxidases in ROS-Dependent Host Cell Death Induced by Pathogenic Entamoeba histolytica.,2022,10.3347/kjp.2022.60.3.155,https://pubmed.ncbi.nlm.nih.gov/35772733/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,31988890,"Personalized Cancer Care: Risk Prediction, Early Diagnosis, Progression, and Therapy.",2016,10.1159/000453253,https://pubmed.ncbi.nlm.nih.gov/31988890/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,33597122,Copy Number Variant Analysis and Genome-wide Association Study Identify Loci with Large Effect for Vesicoureteral Reflux.,2021,10.1681/asn.2020050681,https://pubmed.ncbi.nlm.nih.gov/33597122/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,30560385,[Werner Heyde: psychiatrist and mass murderer : A forensic psychiatric perspective].,2019,10.1007/s00115-018-0650-x,https://pubmed.ncbi.nlm.nih.gov/30560385/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,36186856,Feasibility and efficacy of an acceptance and mindfulness-based group intervention for young people with early psychosis (Feel-Good group).,2022,10.3389/fpsyt.2022.943488,https://pubmed.ncbi.nlm.nih.gov/36186856/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,35712166,Correcting the Bias Correction for the Bootstrap Confidence Interval in Mediation Analysis.,2022,10.3389/fpsyg.2022.810258,https://pubmed.ncbi.nlm.nih.gov/35712166/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,28556894,Analysis of precursors to multiply controlled problem behavior: A replication.,2017,10.1002/jaba.398,https://pubmed.ncbi.nlm.nih.gov/28556894/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,35141809,Specialized inpatient treatment for young people with early psychosis: acute-treatment and 12-month results.,2022,10.1007/s00406-022-01379-8,https://pubmed.ncbi.nlm.nih.gov/35141809/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDPCP,ENSG00000143951,Unsafe,33350891,MRI-based Synthetic CT in the Detection of Structural Lesions in Patients with Suspected Sacroiliitis: Comparison with MRI.,2021,10.1148/radiol.2020201537,https://pubmed.ncbi.nlm.nih.gov/33350891/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,42400031,Prenatal diagnosis of cranioectodermal dysplasia: a case report and review of the literature.,2026,10.1186/s13256-026-06295-2,https://pubmed.ncbi.nlm.nih.gov/42400031/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,40548870,&lt;i&gt;WDR35&lt;/i&gt; Is Associated with Chemosensitivity and Prognosis in Lung Adenocarcinoma.,2025,10.1089/cbr.2025.0124,https://pubmed.ncbi.nlm.nih.gov/40548870/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,42083518,DNAI4 is required for flagellum assembly and male fertility in mice.,2026,10.1242/dev.205190,https://pubmed.ncbi.nlm.nih.gov/42083518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,40445021,Aberrant Splicing Caused by Compound Heterozygous Variants in WDR35 Identified in a Fetus With Cranioectodermal Dysplasia 2.,2025,10.1002/pd.6821,https://pubmed.ncbi.nlm.nih.gov/40445021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,37596520,Novel compound heterozygous WDR35 variants in a Chinese patient associated with cranioectodermal dysplasia and ectopic testis: a case report and review of the literature.,2023,10.1186/s12887-023-04110-1,https://pubmed.ncbi.nlm.nih.gov/37596520/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,38161384,Ciliary phenotyping in renal epithelial cells in a cranioectodermal dysplasia patient with WDR35 variants.,2023,10.3389/fmolb.2023.1285790,https://pubmed.ncbi.nlm.nih.gov/38161384/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,39877340,Case Report: Prenatal diagnosis of novel compound heterozygous variants in WDR35 gene causing short-rib thoracic dysplasia 7 with or without polydactyly.,2024,10.3389/fped.2024.1503455,https://pubmed.ncbi.nlm.nih.gov/39877340/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,34734804,A WDR35-dependent coat protein complex transports ciliary membrane cargo vesicles to cilia.,2021,10.7554/elife.69786,https://pubmed.ncbi.nlm.nih.gov/34734804/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,42385107,Cross-Platform Gene Signature to Predict Survival Outcomes for Nasopharyngeal Carcinoma.,2026,10.1200/po-26-00029,https://pubmed.ncbi.nlm.nih.gov/42385107/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,42450606,Distribution and Evolutionary Implications of Flagellum-Associated Gene Families in Representative Algal Genomes.,2026,10.3390/biology15131058,https://pubmed.ncbi.nlm.nih.gov/42450606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,40045677,Giardia intraflagellar transport protein 88 is involved in flagella formation.,2025,10.3347/phd.24064,https://pubmed.ncbi.nlm.nih.gov/40045677/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,37703354,A TGFβ-ECM-integrin signaling axis drives structural reconfiguration of the bile duct to promote polycystic liver disease.,2023,10.1126/scitranslmed.abq5930,https://pubmed.ncbi.nlm.nih.gov/37703354/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,30570184,"RagA, an mTORC1 activator, interacts with a hedgehog signaling protein, WDR35/IFT121.",2019,10.1111/gtc.12663,https://pubmed.ncbi.nlm.nih.gov/30570184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,25908617,Specific variants in WDR35 cause a distinctive form of Ellis-van Creveld syndrome by disrupting the recruitment of the EvC complex and SMO into the cilium.,2015,10.1093/hmg/ddv152,https://pubmed.ncbi.nlm.nih.gov/25908617/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,33517396,Molecular basis of ciliary defects caused by compound heterozygous IFT144/WDR19 mutations found in cranioectodermal dysplasia.,2021,10.1093/hmg/ddab034,https://pubmed.ncbi.nlm.nih.gov/33517396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,33009702,Association study of genetic variants at TTC32-WDR35 gene cluster with coronary artery disease in Chinese Han population.,2021,10.1002/jcla.23594,https://pubmed.ncbi.nlm.nih.gov/33009702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,27806291,Role for the IFT-A Complex in Selective Transport to the Primary Cilium.,2016,10.1016/j.celrep.2016.10.018,https://pubmed.ncbi.nlm.nih.gov/27806291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,28400947,Mutations in IFT-A satellite core component genes IFT43 and IFT121 produce short rib polydactyly syndrome with distinctive campomelia.,2017,10.1186/s13630-017-0051-y,https://pubmed.ncbi.nlm.nih.gov/28400947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,33421337,Interfamilial clinical variability in four Polish families with cranioectodermal dysplasia and identical compound heterozygous variants in WDR35.,2021,10.1002/ajmg.a.62067,https://pubmed.ncbi.nlm.nih.gov/33421337/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,38531627,Variant characterisation and clinical profile in a large cohort of patients with Ellis-van Creveld syndrome and a family with Weyers acrofacial dysostosis.,2024,10.1136/jmg-2023-109546,https://pubmed.ncbi.nlm.nih.gov/38531627/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,23289926,Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation.,2013,10.1186/1471-2202-14-4,https://pubmed.ncbi.nlm.nih.gov/23289926/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,27207957,Cilia-Associated Genes Play Differing Roles in Aminoglycoside-Induced Hair Cell Death in Zebrafish.,2016,10.1534/g3.116.030080,https://pubmed.ncbi.nlm.nih.gov/27207957/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,28827549,Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS.,2017,10.1038/s41598-017-09320-z,https://pubmed.ncbi.nlm.nih.gov/28827549/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,22751097,Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.,2012,10.1038/ng.2337,https://pubmed.ncbi.nlm.nih.gov/22751097/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,22493696,DNA methylation analysis of bone marrow cells at diagnosis of acute lymphoblastic leukemia and at remission.,2012,10.1371/journal.pone.0034513,https://pubmed.ncbi.nlm.nih.gov/22493696/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR35,ENSG00000118965,Unsafe,20409822,Functional genomics of intraflagellar transport-associated proteins in C. elegans.,2009,10.1016/s0091-679x(08)93014-4,https://pubmed.ncbi.nlm.nih.gov/20409822/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR49,ENSG00000174776,Unsafe,39705191,WDR49-Positive Astrocytes Mark Severity of Neurodegeneration in Frontotemporal Lobar Degeneration and Alzheimer's Disease.,2025,10.1002/glia.24663,https://pubmed.ncbi.nlm.nih.gov/39705191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR49,ENSG00000174776,Unsafe,38995776,Screening Targets and Therapeutic Drugs for Alzheimer's Disease Based on Deep Learning Model and Molecular Docking.,2024,10.3233/jad-231389,https://pubmed.ncbi.nlm.nih.gov/38995776/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR49,ENSG00000174776,Unsafe,33457005,Genome-wide association study of the TP53 R249S mutation in hepatocellular carcinoma with aflatoxin B1 exposure and infection with hepatitis B virus.,2020,10.21037/jgo-20-510,https://pubmed.ncbi.nlm.nih.gov/33457005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR49,ENSG00000174776,Unsafe,33771330,An intrauterine genomic classifier reliably delineates the location of nonviable pregnancies.,2021,10.1016/j.fertnstert.2021.02.005,https://pubmed.ncbi.nlm.nih.gov/33771330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR53,ENSG00000185798,Unsafe,42254588,A fusion-based multiomics classification approach for enhanced gene discovery in non-small cell lung cancer.,2026,10.1093/bioadv/vbag131,https://pubmed.ncbi.nlm.nih.gov/42254588/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR53,ENSG00000185798,Unsafe,36060009,A ubiquitin-related gene signature for predicting prognosis and constructing molecular subtypes in osteosarcoma.,2022,10.3389/fphar.2022.904448,https://pubmed.ncbi.nlm.nih.gov/36060009/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR53,ENSG00000185798,Unsafe,35075228,Construction and validation of a novel gene signature for predicting the prognosis of osteosarcoma.,2022,10.1038/s41598-022-05341-5,https://pubmed.ncbi.nlm.nih.gov/35075228/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR53,ENSG00000185798,Unsafe,23048131,"Analysis of cellulose synthase genes from domesticated apple identifies collinear genes WDR53 and CesA8A: partial co-expression, bicistronic mRNA, and alternative splicing of CESA8A.",2012,10.1093/jxb/ers255,https://pubmed.ncbi.nlm.nih.gov/23048131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,41787126,Microcephaly-associated protein WDR62 supports purine metabolism by interacting with co-chaperone BAG2.,2026,10.1038/s44318-026-00724-0,https://pubmed.ncbi.nlm.nih.gov/41787126/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,41535485,WDR62 is required for proper proliferation and early differentiation of skeletal myoblasts.,2026,10.1038/s42003-026-09537-7,https://pubmed.ncbi.nlm.nih.gov/41535485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,42002830,Prenatal Diagnosis of Autosomal Recessive Primary Microcephaly Type 2 Caused by Compound Heterozygous WDR62 Variants in a Family With Two Recurrent Cases.,2026,10.1002/mgg3.70203,https://pubmed.ncbi.nlm.nih.gov/42002830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,42286901,Genetic causes of the lissencephaly spectrum: insights from chromosomal microarray and clinical/whole-exome sequencing.,2026,,https://pubmed.ncbi.nlm.nih.gov/42286901/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,40369663,WDR62 affects the progression of ovarian cancer by regulating the cell cycle.,2025,10.1186/s41065-025-00444-1,https://pubmed.ncbi.nlm.nih.gov/40369663/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,42131723,Convergent Immune-Coagulation Programs Underlie Gastrointestinal Bleeding Risk in Portal Vein Tumor Thrombosis-Associated Hepatocellular Carcinoma and Portal Hypertension.,2026,10.1155/humu/7210691,https://pubmed.ncbi.nlm.nih.gov/42131723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,41074654,What the fruit fly can tell us about autosomal recessive primary microcephaly.,2025,10.1080/19336934.2025.2572866,https://pubmed.ncbi.nlm.nih.gov/41074654/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,41555927,Expanding the mutational spectrum of congenital microcephaly in Pakistani families.,2025,10.3389/fgene.2025.1709083,https://pubmed.ncbi.nlm.nih.gov/41555927/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,40349858,WDR62 controls cortical radial migration and callosal projection of neurons in the developing cerebral cortex.,2025,10.1016/j.nbd.2025.106951,https://pubmed.ncbi.nlm.nih.gov/40349858/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,41126690,A Human Neural Tube Model Using 4D Self-Folding Smart Scaffolds.,2026,10.1002/adhm.202501405,https://pubmed.ncbi.nlm.nih.gov/41126690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,41714691,Studies on intellectual disability identify variants in established genes as well as confirm candidature of new genes.,2026,10.1038/s41598-026-40182-6,https://pubmed.ncbi.nlm.nih.gov/41714691/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,40694266,Whole-exome sequencing reveals a novel variant in two Iranian families with autosomal recessive primary microcephaly.,2025,10.1007/s11033-025-10833-4,https://pubmed.ncbi.nlm.nih.gov/40694266/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,39911176,Homozygous Intragenic Deletion in &lt;i&gt;WDR62&lt;/i&gt; in Siblings with Primary Microcephaly.,2025,10.1159/000540108,https://pubmed.ncbi.nlm.nih.gov/39911176/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,39808528,WDR62 mediates MAPK/ERK pathway to stimulate DNA damage repair and attenuate cisplatin sensitivity in lung adenocarcinoma.,2025,10.1097/cad.0000000000001682,https://pubmed.ncbi.nlm.nih.gov/39808528/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,38576530,Autosomal recessive primary microcephaly type 2 associated with a novel WDR62 splicing variant that disrupts the expression of the functional transcript.,2024,10.3389/fneur.2024.1341864,https://pubmed.ncbi.nlm.nih.gov/38576530/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,41670011,Diverse Genetic Etiologies of Unilateral Polymicrogyria.,2026,10.1002/ana.78169,https://pubmed.ncbi.nlm.nih.gov/41670011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,40350396,[A case of primary microcephaly associated with compound heterozygous variants of WDR62 gene].,2025,10.3760/cma.j.cn511374-20211201-00951,https://pubmed.ncbi.nlm.nih.gov/40350396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,39060340,KPNA2 promotes the progression of gastric cancer by regulating the alternative splicing of related genes.,2024,10.1038/s41598-024-66678-7,https://pubmed.ncbi.nlm.nih.gov/39060340/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,37272619,Microcephaly-associated protein WDR62 shuttles from the Golgi apparatus to the spindle poles in human neural progenitors.,2023,10.7554/elife.81716,https://pubmed.ncbi.nlm.nih.gov/37272619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,40585306,Novel treatment-specific causal biomarkers for colorectal cancer by omics integration.,2025,10.1093/nargab/lqaf053,https://pubmed.ncbi.nlm.nih.gov/40585306/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,39072983,The liquid-liquid phase separation signature predicts the prognosis and immunotherapy response in hepatocellular carcinoma.,2024,10.1111/jcmm.18446,https://pubmed.ncbi.nlm.nih.gov/39072983/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,34306258,Systematic Analysis of the Oncogenic Role of WDR62 in Human Tumors.,2021,10.1155/2021/9940274,https://pubmed.ncbi.nlm.nih.gov/34306258/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,35808830,WDR62 variants contribute to congenital heart disease by inhibiting cardiomyocyte proliferation.,2022,10.1002/ctm2.941,https://pubmed.ncbi.nlm.nih.gov/35808830/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,40709334,Differential effects of Mediterranean vs. Western diets on coronary atherosclerosis and peripheral artery transcriptomics.,2025,10.3389/fnut.2025.1564741,https://pubmed.ncbi.nlm.nih.gov/40709334/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,40537980,A novel non-invasive mRNA-lncRNA biomarker panel for accurate prediction of cervical squamous cell carcinoma and adenocarcinoma.,2025,10.3802/jgo.2025.36.e81,https://pubmed.ncbi.nlm.nih.gov/40537980/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,30566428,MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis.,2018,10.1371/journal.pbio.2006613,https://pubmed.ncbi.nlm.nih.gov/30566428/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,30091641,WDR62 mediates TNFα-dependent JNK activation via TRAF2-MLK3 axis.,2018,10.1091/mbc.e17-08-0504,https://pubmed.ncbi.nlm.nih.gov/30091641/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,33818783,Diverse genetic causes of polymicrogyria with epilepsy.,2021,10.1111/epi.16854,https://pubmed.ncbi.nlm.nih.gov/33818783/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,19910486,A novel c-Jun N-terminal kinase (JNK)-binding protein WDR62 is recruited to stress granules and mediates a nonclassical JNK activation.,2010,10.1091/mbc.e09-06-0512,https://pubmed.ncbi.nlm.nih.gov/19910486/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,27466283,JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships.,2016,10.1128/mmbr.00043-14,https://pubmed.ncbi.nlm.nih.gov/27466283/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,21668957,"Autosomal Recessive Primary Microcephaly (MCPH): clinical manifestations, genetic heterogeneity and mutation continuum.",2011,10.1186/1750-1172-6-39,https://pubmed.ncbi.nlm.nih.gov/21668957/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR62,ENSG00000075702,Unsafe,20890279,WDR62 is associated with the spindle pole and is mutated in human microcephaly.,2010,10.1038/ng.682,https://pubmed.ncbi.nlm.nih.gov/20890279/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR64,ENSG00000162843,Unsafe,39386799,"WDR64, a testis-specific protein, is involved in the manchette and flagellum formation by interacting with ODF1.",2024,10.1016/j.heliyon.2024.e38263,https://pubmed.ncbi.nlm.nih.gov/39386799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR64,ENSG00000162843,Unsafe,42341506,Effects of N-carbamylglutamate on down yield and quality and thyroid transcriptome in breeding Huoyan geese.,2026,10.1016/j.psj.2026.107256,https://pubmed.ncbi.nlm.nih.gov/42341506/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR64,ENSG00000162843,Unsafe,40221787,Discovery of host genetic factors through multi-locus GWAS against toxoplasmosis in sheep: addressing one health perspectives.,2025,10.1186/s12917-025-04719-7,https://pubmed.ncbi.nlm.nih.gov/40221787/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR64,ENSG00000162843,Unsafe,30315278,The adult human testis transcriptional cell atlas.,2018,10.1038/s41422-018-0099-2,https://pubmed.ncbi.nlm.nih.gov/30315278/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR89,ENSG00000140006,Unsafe,39662264,CircSugp1 interacts with CPSF6 to modulate intestinal mucosa repair by regulating alternative polyadenylation-mediated shortening of the Wdr89 3'UTR.,2025,10.1016/j.intimp.2024.113793,https://pubmed.ncbi.nlm.nih.gov/39662264/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR89,ENSG00000140006,Unsafe,42312281,Expanding the Genetic Blueprint of Wilms Tumor: An Account of 71 Novel Variants across 16 Genes with Novel Implications for Wilms Tumor Pathogenesis.,2026,10.4103/jiaps.jiaps_288_25,https://pubmed.ncbi.nlm.nih.gov/42312281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR89,ENSG00000140006,Unsafe,42793237,Survival-Associated Molecular and Epigenetic Alterations in Endocervical Adenocarcinoma: An Exploratory TCGA Multi-Omics Cohort Study.,2026,10.3390/cimb48090881,https://pubmed.ncbi.nlm.nih.gov/42793237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR89,ENSG00000140006,Unsafe,42698801,Novel Four-gene Panel for Detecting Senescence-associated Cell States in Skeletal Muscle Tissue.,2026,,https://pubmed.ncbi.nlm.nih.gov/42698801/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR89,ENSG00000140006,Unsafe,42072359,Integrative Whole-Genome and Epigenome Profiling of cfDNA in Familial Prostate Cancer: Insights from a Pilot Study.,2026,10.3390/biomedicines14040818,https://pubmed.ncbi.nlm.nih.gov/42072359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR89,ENSG00000140006,Unsafe,39906820,"Discovery of mutated oncodriver genes associated with glioblastoma originated from stem cells of subventricular zone through whole exome sequence profile analysis, and drug repurposing.",2025,10.1016/j.heliyon.2025.e42052,https://pubmed.ncbi.nlm.nih.gov/39906820/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR89,ENSG00000140006,Unsafe,34966342,A Novel Immune Classification for Predicting Immunotherapy Responsiveness in Patients With Adamantinomatous Craniopharyngioma.,2021,10.3389/fneur.2021.704130,https://pubmed.ncbi.nlm.nih.gov/34966342/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR89,ENSG00000140006,Unsafe,38517939,Canadian COVID-19 host genetics cohort replicates known severity associations.,2024,10.1371/journal.pgen.1011192,https://pubmed.ncbi.nlm.nih.gov/38517939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR89,ENSG00000140006,Unsafe,32842198,[Study on expression and mechanism of serum differential proteins after rush immunotherapy of allergic rhinitis].,2020,10.13201/j.issn.2096-7993.2020.08.003,https://pubmed.ncbi.nlm.nih.gov/32842198/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR89,ENSG00000140006,Unsafe,39473539,"Genome-Wide Association Study for Test-Day Milk Yield, Proteins, and Composition Traits of Crossbred Dairy Cattle in Ethiopia.",2024,10.1155/2024/1472779,https://pubmed.ncbi.nlm.nih.gov/39473539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR89,ENSG00000140006,Unsafe,29078390,"WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.",2017,10.1073/pnas.1713625114,https://pubmed.ncbi.nlm.nih.gov/29078390/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR93,ENSG00000140527,Unsafe,37621660,Concurrent loss of ciliary genes WDR93 and CFAP46 in phylogenetically distant birds.,2023,10.1098/rsos.230801,https://pubmed.ncbi.nlm.nih.gov/37621660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WDR93,ENSG00000140527,Unsafe,25558065,Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families.,2015,10.1016/j.celrep.2014.12.015,https://pubmed.ncbi.nlm.nih.gov/25558065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC11,ENSG00000180083,Unsafe,39665756,Large-scale CRISPR/Cas9 deletions within the WFDC gene cluster uncover gene functionality and critical roles in mammalian reproduction.,2024,10.1073/pnas.2413195121,https://pubmed.ncbi.nlm.nih.gov/39665756/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC11,ENSG00000180083,Unsafe,41810385,Genetic risk loci for Parkinson's disease and dementia in a large-scale population-based Taiwanese cohort (TPMI).,2026,10.1016/j.lanwpc.2026.101825,https://pubmed.ncbi.nlm.nih.gov/41810385/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC11,ENSG00000180083,Unsafe,33034631,Lipopolysaccharide-induced epididymitis modifies the transcriptional profile of Wfdc genes in mice†.,2021,10.1093/biolre/ioaa189,https://pubmed.ncbi.nlm.nih.gov/33034631/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC11,ENSG00000180083,Unsafe,21796715,Identification and characterization of Wfdc gene expression in the male reproductive tract of the rat.,2011,10.1002/mrd.21361,https://pubmed.ncbi.nlm.nih.gov/21796715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC3,ENSG00000124116,Unsafe,42295288,Mendelian Randomization and Transcriptomic Analysis Identify HE4 as a Potential Biomarker for Chronic Obstructive Pulmonary Disease.,2026,10.7754/clin.lab.2025.250536,https://pubmed.ncbi.nlm.nih.gov/42295288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC3,ENSG00000124116,Unsafe,42923340,Single-cell and spatial multi-omics combined with machine learning to unravel the heterogeneity of cholangiocarcinoma and the WFDC3-mediated prognostic regulatory mechanisms. ,2026,10.3389/fimmu.2026.1903609,https://pubmed.ncbi.nlm.nih.gov/42923340/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC3,ENSG00000124116,Unsafe,40350979,WFDC3 identified as a prognostic and immune biomarker in pancreatic cancer.,2025,10.17305/bb.2025.12444,https://pubmed.ncbi.nlm.nih.gov/40350979/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC3,ENSG00000124116,Unsafe,39853769,WFDC3 sensitizes colorectal cancer to chemotherapy by regulating ATM/ATR kinase signaling pathway.,2025,10.1096/fj.202402472r,https://pubmed.ncbi.nlm.nih.gov/39853769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC3,ENSG00000124116,Unsafe,37861515,High WFDC3 gene expression is associated with poor prognosis and reduced immune cells infiltration in pancreatic adenocarcinoma: A study using the TCGA database and bioinformatics analysis.,2023,10.1097/md.0000000000035595,https://pubmed.ncbi.nlm.nih.gov/37861515/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC3,ENSG00000124116,Unsafe,39665756,Large-scale CRISPR/Cas9 deletions within the WFDC gene cluster uncover gene functionality and critical roles in mammalian reproduction.,2024,10.1073/pnas.2413195121,https://pubmed.ncbi.nlm.nih.gov/39665756/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC3,ENSG00000124116,Unsafe,41051682,"Association of FANCD2, TFPI, and CD33 genes with prognosis of lung adenocarcinoma: a bioinformatics study.",2025,10.1007/s12672-025-03616-7,https://pubmed.ncbi.nlm.nih.gov/41051682/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC3,ENSG00000124116,Unsafe,42254241,The influence of unhealthy lifestyle on semen quality: results from a cross-sectional study and Mendelian randomization analysis.,2026,10.1097/ms9.0000000000004982,https://pubmed.ncbi.nlm.nih.gov/42254241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC3,ENSG00000124116,Unsafe,42346378,Systems-Level Proteomic and Biochemical Profiling of Plasma from Captive Indian Star Tortoise with Reactome Pathway Enrichment Analysis.,2026,10.3390/metabo16060398,https://pubmed.ncbi.nlm.nih.gov/42346378/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC3,ENSG00000124116,Unsafe,39990193,Exploring Molecular Alterations in Breast Cancer Among Indian Women Using Label-Free Quantitative Serum Proteomics.,2024,10.1155/bri/5584607,https://pubmed.ncbi.nlm.nih.gov/39990193/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC3,ENSG00000124116,Unsafe,37443102,WFDC3 inhibits tumor metastasis by promoting the ERβ-mediated transcriptional repression of TGFBR1 in colorectal cancer.,2023,10.1038/s41419-023-05956-0,https://pubmed.ncbi.nlm.nih.gov/37443102/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC3,ENSG00000124116,Unsafe,26057447,Multiple Changes of Gene Expression and Function Reveal Genomic and Phenotypic Complexity in SLE-like Disease.,2015,10.1371/journal.pgen.1005248,https://pubmed.ncbi.nlm.nih.gov/26057447/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC3,ENSG00000124116,Unsafe,33034631,Lipopolysaccharide-induced epididymitis modifies the transcriptional profile of Wfdc genes in mice†.,2021,10.1093/biolre/ioaa189,https://pubmed.ncbi.nlm.nih.gov/33034631/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC3,ENSG00000124116,Unsafe,28439009,"Estrogen receptor β, a regulator of androgen receptor signaling in the mouse ventral prostate.",2017,10.1073/pnas.1702211114,https://pubmed.ncbi.nlm.nih.gov/28439009/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFDC3,ENSG00000124116,Unsafe,12574366,Mouse SWAM1 and SWAM2 are antibacterial proteins composed of a single whey acidic protein motif.,2003,10.4049/jimmunol.170.4.1973,https://pubmed.ncbi.nlm.nih.gov/12574366/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,41194281,WFIKKN2 is secreted and elevated in blood plasma of HER2-positive breast cancer patients - implications in cancer surveillance and recurrence monitoring.,2025,10.1186/s40364-025-00853-4,https://pubmed.ncbi.nlm.nih.gov/41194281/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,41855608,Identifying prioritization of potential targets for idiopathic pulmonary fibrosis: Proteome-wide Mendelian randomization and colocalization analyses.,2026,10.1016/j.clinsp.2026.100913,https://pubmed.ncbi.nlm.nih.gov/41855608/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,40490152,Development and characterization of endolysosomal trafficking targeting chimera degraders of α&lt;sub&gt;1A&lt;/sub&gt;-adrenergic receptor.,2026,10.1016/j.jare.2025.06.014,https://pubmed.ncbi.nlm.nih.gov/40490152/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,41820573,Molecular characterization and functional effect on canie peripheral blood mononuclear cells of phosphoglycerate kinase from Echinococcus granulosus.,2026,10.1007/s00436-026-08625-1,https://pubmed.ncbi.nlm.nih.gov/41820573/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,41681433,Transcriptomic Exploration of Muscle Development and Fat Deposition Trait Diversity in Selected Indian Sheep Breeds: Implications for Meat Quality and Yield.,2026,10.3390/ani16030452,https://pubmed.ncbi.nlm.nih.gov/41681433/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,41299996,"Integrative Analysis of Flavoromics, Lipidomics, and Transcriptomics Reveals the Potential Mechanisms Underlying the Unique Meat Flavor of Jianli Pigs.",2025,10.3390/foods14223838,https://pubmed.ncbi.nlm.nih.gov/41299996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,37235639,Relationships of GDF8 and 11 and Their Antagonists With Decline of Grip Strength Among Older Adults in the Baltimore Longitudinal Study of Aging.,2023,10.1093/gerona/glad135,https://pubmed.ncbi.nlm.nih.gov/37235639/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,42000070,Effects of Arvcf on anxiety- and depression-like behaviors in mice of different ages and sexes.,2026,10.1016/j.jad.2026.121790,https://pubmed.ncbi.nlm.nih.gov/42000070/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,36042202,GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to paclitaxel by forming a vicious cycle with IGF1/IGF1R signaling pathway.,2022,10.1038/s41419-022-05198-6,https://pubmed.ncbi.nlm.nih.gov/36042202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,40891161,Profiling Cytokines According to the Presence or Absence of Small-for-Gestational Age Using Amniotic Fluid Retrieved During Cesarean Section From Pregnant Women With Early-Onset Preeclampsia.,2025,10.3346/jkms.2025.40.e213,https://pubmed.ncbi.nlm.nih.gov/40891161/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,40463815,Causal effects and plasma protein mediators between type 2 diabetes and erectile dysfunction: a Mendelian randomization study.,2025,10.1093/sexmed/qfae097,https://pubmed.ncbi.nlm.nih.gov/40463815/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,39139173,"The expression of miR-21, HSP90a and gGASP-1 in serum of patients with lung cancer and their correlation with pathological subtypes.",2024,10.5937/jomb0-48051,https://pubmed.ncbi.nlm.nih.gov/39139173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,40033180,Dissecting genomes of multiple yak populations: unveiling ancestry and high-altitude adaptation through whole-genome resequencing analysis.,2025,10.1186/s12864-025-11387-2,https://pubmed.ncbi.nlm.nih.gov/40033180/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,37409929,The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs.,2023,10.1080/15548627.2023.2233872,https://pubmed.ncbi.nlm.nih.gov/37409929/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,37844531,Transcriptomics analysis unveils key potential genes associated with brain development and feeding behavior in the hypothalamus of L-citrulline-fed broiler chickens.,2023,10.1016/j.psj.2023.103136,https://pubmed.ncbi.nlm.nih.gov/37844531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,33627659,Revealing the role of the human blood plasma proteome in obesity using genetic drivers.,2021,10.1038/s41467-021-21542-4,https://pubmed.ncbi.nlm.nih.gov/33627659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,38284902,Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.,2024,10.18632/aging.205386,https://pubmed.ncbi.nlm.nih.gov/38284902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,35819066,PILS proteins provide a homeostatic feedback on auxin signaling output.,2022,10.1242/dev.200929,https://pubmed.ncbi.nlm.nih.gov/35819066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,36931452,Arrestin-3 Agonism at Dopamine D&lt;sub&gt;3&lt;/sub&gt; Receptors Defines a Subclass of Second-Generation Antipsychotics That Promotes Drug Tolerance.,2023,10.1016/j.biopsych.2023.03.006,https://pubmed.ncbi.nlm.nih.gov/36931452/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,33608268,An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system.,2021,10.1126/sciadv.abc8310,https://pubmed.ncbi.nlm.nih.gov/33608268/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,41513169,"Proteomic effects of short-term liraglutide vs. placebo in a blinded crossover RCT: Implications for efficacy, safety, and comparison with semaglutide.",2026,10.1016/j.metabol.2026.156493,https://pubmed.ncbi.nlm.nih.gov/41513169/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,35510530,"Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin.",2022,10.1002/jcsm.12998,https://pubmed.ncbi.nlm.nih.gov/35510530/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,23884939,Loss of D2 dopamine receptor function modulates cocaine-induced glutamatergic synaptic potentiation in the ventral tegmental area.,2013,10.1523/jneurosci.0809-13.2013,https://pubmed.ncbi.nlm.nih.gov/23884939/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,17428994,A molecular basis of analgesic tolerance to cannabinoids.,2007,10.1523/jneurosci.5648-06.2007,https://pubmed.ncbi.nlm.nih.gov/17428994/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,25821972,Transcriptome analysis of post-hatch breast muscle in legacy and modern broiler chickens reveals enrichment of several regulators of myogenic growth.,2015,10.1371/journal.pone.0122525,https://pubmed.ncbi.nlm.nih.gov/25821972/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WFIKKN2,ENSG00000173714,Unsafe,11928817,Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules.,2002,10.1515/bc.2002.023,https://pubmed.ncbi.nlm.nih.gov/11928817/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,42715818,Integrative transcriptomic analysis reveals KLHL2 downregulation as a potential driver of microglial inflammation in Alzheimer's disease via the WNK3/JNK/c-Jun axis.,2026,10.1016/j.neurot.2026.e01069,https://pubmed.ncbi.nlm.nih.gov/42715818/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,42185697,Acupuncture improves neurological function in ICH rats via suppression of WNK-SPAK-NKCC1 signaling activation.,2026,10.1007/s10735-026-10834-y,https://pubmed.ncbi.nlm.nih.gov/42185697/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,42509784,Sensitive Molecules Involved in Spatial Learning and Memory Impairment of Mice Induced by 4.3 GHz Microwave Radiation.,2026,10.3390/biom16070990,https://pubmed.ncbi.nlm.nih.gov/42509784/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,42333465,Decreased miR-1305 expression is associated with tumour invasiveness and poor prognosis in glioma patients.,2026,10.1080/00207454.2026.2686992,https://pubmed.ncbi.nlm.nih.gov/42333465/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,41875288,Clinical Significance of miR-28-5p in Ischemic Stroke and Its Neuroprotective Effect after Ischemia-Reperfusion Injury.,2026,10.1159/000551361,https://pubmed.ncbi.nlm.nih.gov/41875288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,40993905,Increased expression of WNK3 during the perinatal period in newborn rats with hypoxic-ischemic encephalopathy.,2025,10.1080/02699052.2025.2558956,https://pubmed.ncbi.nlm.nih.gov/40993905/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,40602592,ZFHX3 silencing alleviates ischemic stroke by suppressing pericyte contraction and calcium influx through inhibiting WNK3 expression.,2025,10.1016/j.expneurol.2025.115363,https://pubmed.ncbi.nlm.nih.gov/40602592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,39584807,Water and chloride as allosteric inhibitors in WNK kinase osmosensing.,2024,10.7554/elife.88224,https://pubmed.ncbi.nlm.nih.gov/39584807/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,41616282,Multiomics analysis of red blood cells reveals thalassemia severity beyond globin gene mutations.,2026,10.1182/bloodadvances.2025016677,https://pubmed.ncbi.nlm.nih.gov/41616282/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,42497608,Taurine ameliorates damages induced by acute heat stress on porcine Sertoli cells.,2026,10.1016/j.theriogenology.2026.118104,https://pubmed.ncbi.nlm.nih.gov/42497608/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,35678782,Rare pathogenic variants in WNK3 cause X-linked intellectual disability.,2022,10.1016/j.gim.2022.05.009,https://pubmed.ncbi.nlm.nih.gov/35678782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,42186973,Structural Basis for Potassium Inhibition of WNK Kinases.,2026,10.1021/acs.biochem.5c00825,https://pubmed.ncbi.nlm.nih.gov/42186973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,39633006,X-chromosome-wide association study for Alzheimer's disease.,2025,10.1038/s41380-024-02838-5,https://pubmed.ncbi.nlm.nih.gov/39633006/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,37296437,Testis cell pyroptosis mediated by CASP1 and CASP4: possible sertoli cell-only syndrome pathogenesis.,2023,10.1186/s12958-023-01101-w,https://pubmed.ncbi.nlm.nih.gov/37296437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,39267058,Whole exome sequencing analysis of 167 men with primary infertility.,2024,10.1186/s12920-024-02005-3,https://pubmed.ncbi.nlm.nih.gov/39267058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,34858138,"WNK3 Maintains the GABAergic Inhibitory Tone, Synaptic Excitation and Neuronal Excitability via Regulation of KCC2 Cotransporter in Mature Neurons.",2021,10.3389/fnmol.2021.762142,https://pubmed.ncbi.nlm.nih.gov/34858138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,36311015,WNK3 kinase maintains neuronal excitability by reducing inwardly rectifying K+ conductance in layer V pyramidal neurons of mouse medial prefrontal cortex.,2022,10.3389/fnmol.2022.856262,https://pubmed.ncbi.nlm.nih.gov/36311015/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,36357569,WNK3 inhibition elicits antitumor immunity by suppressing PD-L1 expression on tumor cells and activating T-cell function.,2022,10.1038/s12276-022-00876-z,https://pubmed.ncbi.nlm.nih.gov/36357569/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,36712947,Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening.,2023,10.2147/dddt.s389461,https://pubmed.ncbi.nlm.nih.gov/36712947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,35273702,WNK3-PER1 interactions regulate the circadian rhythm in the suprachiasmatic nucleus in rats.,2022,,https://pubmed.ncbi.nlm.nih.gov/35273702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,34863180,Silencing of the lncRNA H19 enhances sensitivity to X-ray and carbon-ions through the miR-130a-3p /WNK3 signaling axis in NSCLC cells.,2021,10.1186/s12935-021-02268-1,https://pubmed.ncbi.nlm.nih.gov/34863180/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,39841180,PTPN23-dependent activation of PI3KC2α is a therapeutic vulnerability of BRAF-mutant cancers.,2025,10.1084/jem.20241147,https://pubmed.ncbi.nlm.nih.gov/39841180/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,35163434,Kinome-Wide Profiling Identifies Human WNK3 as a Target of Cajanin Stilbene Acid from Cajanus cajan (L.) Millsp.,2022,10.3390/ijms23031506,https://pubmed.ncbi.nlm.nih.gov/35163434/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,37585288,Hydrostatic Pressure Sensing by WNK kinases.,2023,10.1091/mbc.e23-03-0113,https://pubmed.ncbi.nlm.nih.gov/37585288/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,26861815,Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke.,2017,10.1177/0271678x16631561,https://pubmed.ncbi.nlm.nih.gov/26861815/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,34680965,Alternative Splicing Mechanisms Underlying Opioid-Induced Hyperalgesia.,2021,10.3390/genes12101570,https://pubmed.ncbi.nlm.nih.gov/34680965/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,34598322,A construction and comprehensive analysis of ceRNA networks and infiltrating immune cells in papillary renal cell carcinoma.,2021,10.1002/cam4.4309,https://pubmed.ncbi.nlm.nih.gov/34598322/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,31281492,Molecularly annotation of mouse avatar models derived from patients with colorectal cancer liver metastasis.,2019,10.7150/thno.32033,https://pubmed.ncbi.nlm.nih.gov/31281492/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,20094755,Emerging roles for WNK kinases in cancer.,2010,10.1007/s00018-010-0261-6,https://pubmed.ncbi.nlm.nih.gov/20094755/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,21963515,The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension.,2011,10.1038/nm.2497,https://pubmed.ncbi.nlm.nih.gov/21963515/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,16275913,"WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis.",2005,10.1073/pnas.0508303102,https://pubmed.ncbi.nlm.nih.gov/16275913/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,15194194,"Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3).",2004,10.1016/j.gene.2004.03.009,https://pubmed.ncbi.nlm.nih.gov/15194194/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNK3,ENSG00000196632,Unsafe,11571656,"WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.",2001,10.1038/sj.onc.1204726,https://pubmed.ncbi.nlm.nih.gov/11571656/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,42769453,Bruceine A attenuates renal tubulointerstitial fibrosis by inhibiting the Wnt7a/PI3K/AKT pathway.,2026,10.3389/fphar.2026.1865261,https://pubmed.ncbi.nlm.nih.gov/42769453/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,41566350,Photoperiodic regulation of Wnts in spermatogenesis of Brandt's vole (Lasiopodomys brandtii).,2026,10.1186/s12983-026-00596-4,https://pubmed.ncbi.nlm.nih.gov/41566350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,42726311,METTL14 alleviates pyroptosis of placental trophoblasts in gestational diabetes mellitus through the lncRNA MEG8/WNT7A axis via m6A modification.,2026,10.1007/s10142-026-01986-x,https://pubmed.ncbi.nlm.nih.gov/42726311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,42903334,Engrailed-1 in eccrine sweat gland development and regeneration: from evolutionary innovation to therapeutic perspectives.,2026,10.3389/fcell.2026.1917336,https://pubmed.ncbi.nlm.nih.gov/42903334/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,42348420,The calcium pump ATP2B1/PMCA1 regulates CNS vascular development by facilitating Norrin- and WNT7A/B-induced Frizzled4 signaling.,2026,10.1016/j.celrep.2026.117605,https://pubmed.ncbi.nlm.nih.gov/42348420/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,42025402,Wnt7a mediates the Wnt/β-catenin signaling pathway to influence ferroptosis in T lymphocytes of HIV-infected individuals.,2026,10.1016/j.molimm.2026.04.009,https://pubmed.ncbi.nlm.nih.gov/42025402/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,41732723,Hippocampal expression of Wnt7a and β-catenin in depression: evidence from chronic unpredictable mild stress.,2026,10.7717/peerj.20837,https://pubmed.ncbi.nlm.nih.gov/41732723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,41891408,Combined impact of ROR2 and its ligands on the pathogenesis and prognosis of idiopathic pulmonary fibrosis.,2026,10.36141/svdld.2026.17921,https://pubmed.ncbi.nlm.nih.gov/41891408/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,42472097,&lt;i&gt;LAMA5&lt;/i&gt; links extracellular matrix organization to a candidate WNT-associated endothelial signaling niche during human chondrogenesis.,2026,10.1016/j.isci.2026.116687,https://pubmed.ncbi.nlm.nih.gov/42472097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,42236896,Tumor-derived WNT7A reprograms pulmonary fibroblasts to remodel the metastatic niche and promote bladder cancer lung metastasis.,2026,10.1038/s12276-026-01735-x,https://pubmed.ncbi.nlm.nih.gov/42236896/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,42688698,Spatially resolved transcriptomics identifies epithelial-specific oncogenic signaling networks in ameloblastoma.,2026,10.1016/j.jds.2025.07.3487,https://pubmed.ncbi.nlm.nih.gov/42688698/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,42367224,Extracellular Matrix-Related Prognostic Signature for Head and Neck Squamous Cell Carcinoma via Multi-Algorithm Survival Modeling.,2026,10.1177/11772719261463532,https://pubmed.ncbi.nlm.nih.gov/42367224/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,42091587,HPCAL1 promotes colorectal cancer progression via TCF7/p65-mediated Wnt ligand upregulation and Wnt/β-catenin pathway activation.,2026,10.1038/s41389-026-00618-0,https://pubmed.ncbi.nlm.nih.gov/42091587/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,42131338,Evaluation of translational potential of mRNA vaccine candidate antigens for pancreatic cancer: a systematic review based on clinical evidence and stratified prioritization strategies.,2026,10.3389/fimmu.2026.1803792,https://pubmed.ncbi.nlm.nih.gov/42131338/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,41946008,WNT7A correlates with immunosuppression and predicts adverse prognosis in lung adenocarcinoma: Potential implication of the NF-κB/CCL2 Axis.,2026,10.1016/j.cyto.2026.157144,https://pubmed.ncbi.nlm.nih.gov/41946008/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,42269502,Transcriptional analysis of WNT-related genes in uterine samples on day 16 from pregnant and non-pregnant Holstein dairy cows.,2026,10.1016/j.theriogenology.2026.118022,https://pubmed.ncbi.nlm.nih.gov/42269502/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,42291596,Exploring the shared biomarkers between acute ischemia stroke and diabetes by transcriptome sequencing.,2026,10.12669/pjms.42.5.12759,https://pubmed.ncbi.nlm.nih.gov/42291596/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,40663208,Regulatory effects of head acupuncture on the GABAergic system and Wnt7a/β-catenin pathway in post-stroke spasticity rats.,2025,10.1007/s10735-025-10505-4,https://pubmed.ncbi.nlm.nih.gov/40663208/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,42007489,Role of the WNT signalling pathway in physiological and pathological blood-brain barrier.,2026,10.1080/07853890.2026.2657638,https://pubmed.ncbi.nlm.nih.gov/42007489/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,41636059,Loss of ROR2 Tyrosine Kinase Receptor Is Associated With Endothelial Dysfunction in PAH via Inappropriate Integrin β1 Activation.,2026,10.1161/hypertensionaha.125.25881,https://pubmed.ncbi.nlm.nih.gov/41636059/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,39602462,Blocking WNT7A Enhances MHC-I Antigen Presentation and Enhances the Effectiveness of Immune Checkpoint Blockade Therapy.,2025,10.1158/2326-6066.cir-24-0484,https://pubmed.ncbi.nlm.nih.gov/39602462/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,40867532,Melatonin as an Alleviator in Decabromodiphenyl Ether-Induced Aberrant Hippocampal Neurogenesis and Synaptogenesis: The Role of Wnt7a.,2025,10.3390/biom15081087,https://pubmed.ncbi.nlm.nih.gov/40867532/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,40950805,&lt;i&gt;WNT7A&lt;/i&gt; mRNA Lipid Nanoparticles Promote Muscle Hypertrophy and Reduce Fatty Infiltration.,2025,10.1007/s12195-025-00859-w,https://pubmed.ncbi.nlm.nih.gov/40950805/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,41480707,The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review).,2026,10.3892/ijmm.2025.5724,https://pubmed.ncbi.nlm.nih.gov/41480707/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,40944523,"Thyroid hormone receptor blockade by amiodarone disrupts angiogenesis via VEGFα, WNT7A, BMP, and PI3K/AKT pathways in chick embryo vascular development.",2026,10.1002/dvdy.70076,https://pubmed.ncbi.nlm.nih.gov/40944523/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,40914247,WNT7A/B assemble a GPR124-RECK-LRP5/6 coreceptor complex to activate β-catenin signaling in brain endothelial cells.,2025,10.1016/j.jbc.2025.110682,https://pubmed.ncbi.nlm.nih.gov/40914247/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,42161564,B7-H4 Promotes MFC Cell Proliferation and Tumor Formation by Activating the IL-6/STAT3 Pathway.,2026,10.1620/tjem.2026.j053,https://pubmed.ncbi.nlm.nih.gov/42161564/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,42635896,"Phytochemical and Molecular Insights Into the Anti-PCOS Potential of Anchusa Strigosa: Targeting Hormones, Biochemical Markers, and WNT Genes.",2026,10.1007/s12010-026-05887-4,https://pubmed.ncbi.nlm.nih.gov/42635896/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
WNT7A,ENSG00000154764,Unsafe,42774326,Cloning of a novel cyanobacterial serotonin N-acetyltransferase gene CySNAT3 and its integration with transcriptomic drug repurposing in pediatric obstructive sleep-disordered breathing.,2026,10.3389/fphar.2026.1851793,https://pubmed.ncbi.nlm.nih.gov/42774326/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE2,ENSG00000155622,Unsafe,39991573,Integrative multi-omics and machine learning identify a robust signature for discriminating prognosis and therapeutic targets in bladder cancer.,2025,10.7150/jca.105066,https://pubmed.ncbi.nlm.nih.gov/39991573/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE2,ENSG00000155622,Unsafe,33879671,In silico screening using bulk and single-cell RNA-seq data identifies RIMS2 as a prognostic marker in basal-like breast cancer: A retrospective study.,2021,10.1097/md.0000000000025414,https://pubmed.ncbi.nlm.nih.gov/33879671/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE2,ENSG00000155622,Unsafe,31675487,Transcriptomic features of trophoblast lineage cells derived from human induced pluripotent stem cells treated with BMP 4.,2020,10.1016/j.placenta.2019.10.006,https://pubmed.ncbi.nlm.nih.gov/31675487/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE2,ENSG00000155622,Unsafe,32990583,Exploring Potential Proteomic Biomarkers for Prognosis of Infective Endocarditis through Profiled Autoantibodies by an Immunomics Protein Array Technique.,2020,10.1532/hsf.3017,https://pubmed.ncbi.nlm.nih.gov/32990583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE2,ENSG00000155622,Unsafe,31365696,Gene expression profiling reveals upregulated FUT1 and MYBPC1 in children with pancreaticobiliary maljunction.,2019,10.1590/1414-431x20198522,https://pubmed.ncbi.nlm.nih.gov/31365696/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE2,ENSG00000155622,Unsafe,23574628,"Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene.",2013,10.1111/tan.12113,https://pubmed.ncbi.nlm.nih.gov/23574628/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE3,ENSG00000171402,Unsafe,39949781,Identification and validation of a novel autoantibody biomarker panel for differential diagnosis of pancreatic ductal adenocarcinoma.,2025,10.3389/fimmu.2025.1494446,https://pubmed.ncbi.nlm.nih.gov/39949781/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE3,ENSG00000171402,Unsafe,33437360,"Expression profile of ACTL8, CTCFL, OIP5 and XAGE3 in glioma and their prognostic significance: a retrospective clinical study.",2020,,https://pubmed.ncbi.nlm.nih.gov/33437360/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE3,ENSG00000171402,Unsafe,30006881,Specific Features of Transcription Activity of Cancer-Testis Antigens in Patients with Metastatic and Non-Metastatic Breast Cancer.,2018,10.1007/s10517-018-4175-x,https://pubmed.ncbi.nlm.nih.gov/30006881/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE3,ENSG00000171402,Unsafe,32799221,[Regulation of Gene Expression of Cancer/Testis Antigens in Colorectal Cancer Patients].,2020,10.31857/s0026898420040096,https://pubmed.ncbi.nlm.nih.gov/32799221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE3,ENSG00000171402,Unsafe,31533811,Screening circulating proteins to identify biomarkers of fetal macrosomia.,2019,10.1186/s13104-019-4625-1,https://pubmed.ncbi.nlm.nih.gov/31533811/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE3,ENSG00000171402,Unsafe,23592437,Expression of cancer/testis antigens is correlated with improved survival in glioblastoma.,2013,10.18632/oncotarget.950,https://pubmed.ncbi.nlm.nih.gov/23592437/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XAGE3,ENSG00000171402,Unsafe,25742136,Dysregulation of X chromosome inactivation in high grade ovarian serous adenocarcinoma.,2015,10.1371/journal.pone.0118927,https://pubmed.ncbi.nlm.nih.gov/25742136/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XKR9,ENSG00000221947,Unsafe,41830132,The Xkr protein family-From apoptosis executors to diverse physiological functions regulators.,2026,10.1002/1873-3468.70327,https://pubmed.ncbi.nlm.nih.gov/41830132/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XKR9,ENSG00000221947,Unsafe,40284797,Validation of Polymorphisms Associated with the Immune Response After Vaccination Against Porcine Reproductive and Respiratory Syndrome Virus in Yorkshire Gilts.,2025,10.3390/vetsci12040295,https://pubmed.ncbi.nlm.nih.gov/40284797/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XKR9,ENSG00000221947,Unsafe,34263724,Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling.,2021,10.7554/elife.69800,https://pubmed.ncbi.nlm.nih.gov/34263724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XKR9,ENSG00000221947,Unsafe,32920960,Genetic factors associated with cancer racial disparity - an integrative study across twenty-one cancer types.,2020,10.1002/1878-0261.12799,https://pubmed.ncbi.nlm.nih.gov/32920960/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XKR9,ENSG00000221947,Unsafe,25231987,Exposure of phosphatidylserine by Xk-related protein family members during apoptosis.,2014,10.1074/jbc.m114.583419,https://pubmed.ncbi.nlm.nih.gov/25231987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,42792578,N-Terminal Basic Helix and S120 Phosphorylation Cooperatively Regulate Nuclear Localization of UBE2A/B in Mechanotransduction.,2026,10.3390/biology15181633,https://pubmed.ncbi.nlm.nih.gov/42792578/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,42155730,Proteomic Analysis on Human Islets Suggests Nucleocytoplasmic Transport as a Mechanism of PERK Attenuation Effects in Diabetes.,2026,10.1016/j.mcpro.2026.101588,https://pubmed.ncbi.nlm.nih.gov/42155730/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,38722973,Exportin 4 DNA promoter methylation in liver fibrosis.,2024,10.1371/journal.pone.0302786,https://pubmed.ncbi.nlm.nih.gov/38722973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,42466995,From Delithiated Residues to High-Performance LiMn0.4Fe0.6PO4 through Structural Inheritance and F-Doping toward Upcycling of Spent Lithium-Ion Batteries.,2026,10.1021/acs.nanolett.6c01751,https://pubmed.ncbi.nlm.nih.gov/42466995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,36182935,Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs.,2022,10.1038/s41467-022-33356-z,https://pubmed.ncbi.nlm.nih.gov/36182935/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,41162879,Proteomic signature of aging in bloodstain samples: a preliminary study.,2025,10.1186/s12864-025-12164-x,https://pubmed.ncbi.nlm.nih.gov/41162879/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,42068200,From Genomic Instability to Epigenetic Signatures: The Evolving Landscape of Circulating Cell-free DNA in Metabolic Dysfunction-Associated Steatotic Liver Disease.,2026,10.1111/hepr.70198,https://pubmed.ncbi.nlm.nih.gov/42068200/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,41439028,"TPR is required for circRNA, lncRNA and mRNA nuclear export.",2026,10.1016/j.ncrna.2025.11.010,https://pubmed.ncbi.nlm.nih.gov/41439028/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,39776001,Analysis of exportins expression unveils their prognostic significance in colon adenocarcinoma: insights from public databases.,2025,10.1007/s12672-025-01748-4,https://pubmed.ncbi.nlm.nih.gov/39776001/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,37239394,A Novel 13q12 Microdeletion Associated with Familial Syndromic Corneal Opacification.,2023,10.3390/genes14051034,https://pubmed.ncbi.nlm.nih.gov/37239394/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,37270558,"Investigation of enzalutamide, docetaxel, and cabazitaxel resistance in the castration resistant prostate cancer cell line C4 using genome-wide CRISPR/Cas9 screening.",2023,10.1038/s41598-023-35950-7,https://pubmed.ncbi.nlm.nih.gov/37270558/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,34388518,Copy number variation and expression of exportin-4 associates with severity of fibrosis in metabolic associated fatty liver disease.,2021,10.1016/j.ebiom.2021.103521,https://pubmed.ncbi.nlm.nih.gov/34388518/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,33955481,Exportin-4 coordinates nuclear shuttling of TOPLESS family transcription corepressors to regulate plant immunity.,2021,10.1093/plcell/koaa047,https://pubmed.ncbi.nlm.nih.gov/33955481/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,34073819,Porcine Milk-Derived Small Extracellular Vesicles Promote Intestinal Immunoglobulin Production through pIgR.,2021,10.3390/ani11061522,https://pubmed.ncbi.nlm.nih.gov/34073819/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,38340287,Peptidylprolyl isomerase D circular RNA sensitizes breast cancer to trastuzumab through remodeling HER2 N4-acetylcytidine modification.,2024,10.1007/s13353-024-00840-9,https://pubmed.ncbi.nlm.nih.gov/38340287/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,26293807,Copy number variation in exportin-4 (XPO4) gene and its association with histological severity of non-alcoholic fatty liver disease.,2015,10.1038/srep13306,https://pubmed.ncbi.nlm.nih.gov/26293807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,33987341,Global alternative splicing landscape of skeletal muscle atrophy induced by hindlimb unloading.,2021,10.21037/atm-20-5388,https://pubmed.ncbi.nlm.nih.gov/33987341/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,31371628,Prognostic roles of the transcriptional expression of exportins in hepatocellular carcinoma.,2019,10.1042/bsr20190827,https://pubmed.ncbi.nlm.nih.gov/31371628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,27306458,Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A.,2016,10.1038/ncomms11952,https://pubmed.ncbi.nlm.nih.gov/27306458/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,24597692,Exportin 4 gene expression and DNA promoter methylation status in chronic hepatitis B virus infection.,2014,10.1111/jvh.12136,https://pubmed.ncbi.nlm.nih.gov/24597692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,42232859,Upcycling of LiFePO&lt;sub&gt;4&lt;/sub&gt; to high-performance LiMn &lt;sub&gt;&lt;i&gt;x&lt;/i&gt;&lt;/sub&gt; Fe&lt;sub&gt;1-&lt;i&gt;x&lt;/i&gt;&lt;/sub&gt; PO&lt;sub&gt;4&lt;/sub&gt;: activating the Mn redox platform for stable energy storage.,2026,10.1039/d6sc03686d,https://pubmed.ncbi.nlm.nih.gov/42232859/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,42171420,Unlocking Low-Energy-Barrier Pathways via Monoclinic Acceptor Induction for Homogeneous Regeneration of Spent LiMn&lt;sub&gt;x&lt;/sub&gt;Fe&lt;sub&gt;1-&lt;/sub&gt; &lt;sub&gt;x&lt;/sub&gt;PO&lt;sub&gt;4&lt;/sub&gt; Cathodes.,2026,10.1002/anie.7687036,https://pubmed.ncbi.nlm.nih.gov/42171420/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,34112910,Hydrothermally synthesized nanostructured LiMnxFe1-xPO4 (x = 0-0.3) cathode materials with enhanced properties for lithium-ion batteries.,2021,10.1038/s41598-021-91881-1,https://pubmed.ncbi.nlm.nih.gov/34112910/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,25778467,Genetic modifiers of response to glucose-insulin-potassium (GIK) infusion in acute coronary syndromes and associations with clinical outcomes in the IMMEDIATE trial.,2015,10.1038/tpj.2015.10,https://pubmed.ncbi.nlm.nih.gov/25778467/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XPO4,ENSG00000132953,Unsafe,28773887,The Synthesis of LiMnxFe1-xPO₄/C Cathode Material through Solvothermal Jointed with Solid-State Reaction.,2016,10.3390/ma9090766,https://pubmed.ncbi.nlm.nih.gov/28773887/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,41885368,Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients.,2026,10.1002/1878-0261.70244,https://pubmed.ncbi.nlm.nih.gov/41885368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,41413892,The RAD51 paralogue HvXRCC2 affects meiosis and recombination in barley.,2026,10.1093/jxb/eraf489,https://pubmed.ncbi.nlm.nih.gov/41413892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,42052925,Maize XRCC2 participates in somatic DNA repair and meiotic crossover formation.,2026,10.1093/plphys/kiag255,https://pubmed.ncbi.nlm.nih.gov/42052925/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,42169974,Particulate Hexavalent Chromium Inhibits RAD51 Paralogs Necessary for RAD51 Filament Formation and Stabilization During Homologous Recombination Repair.,2026,10.3390/occuphealth1010013,https://pubmed.ncbi.nlm.nih.gov/42169974/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,40466561,The association between XRCC2 and BCORL1 expression with sperm DNA fragmentation index in infertile men candidates undergoing intracytoplasmic sperm injection (ICSI).,2025,10.1016/j.tice.2025.102982,https://pubmed.ncbi.nlm.nih.gov/40466561/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,41832372,Identification of a biologically coherent three gene immune signature predictive of immunotherapy benefit in gastric adenocarcinoma.,2026,10.1007/s12672-026-04831-6,https://pubmed.ncbi.nlm.nih.gov/41832372/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,39090304,XRCC2 driven homologous recombination subtypes and therapeutic targeting in lung adenocarcinoma metastasis.,2024,10.1038/s41698-024-00658-y,https://pubmed.ncbi.nlm.nih.gov/39090304/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,41772053,BCDX2-CX3 and DX2-CX3 complexes assemble and stabilize RAD51 filaments.,2026,10.1038/s41586-026-10314-z,https://pubmed.ncbi.nlm.nih.gov/41772053/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,40202151,Bioinformatics Combined With Biological Experiments to Identify the Pathogenetic Link of Type 2 Diabetes for Breast Cancer.,2025,10.1002/cam4.70759,https://pubmed.ncbi.nlm.nih.gov/40202151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,41189020,Piwi-interacting RNA 775 (piR-775) predicts favorable prognosis and regulates cell cycle and DNA damage response pathways in breast cancer.,2025,10.1186/s40364-025-00856-1,https://pubmed.ncbi.nlm.nih.gov/41189020/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,39097872,"Association of XRCC2 with breast cancer, a multi-omics analysis at genomic, transcriptomic, and epigenomic level.",2024,10.14715/cmb/2024.70.7.36,https://pubmed.ncbi.nlm.nih.gov/39097872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,42415513,Impact of Multigene Panel Testing in High-Risk Uveal Melanoma Patients.,2026,10.1111/pcmr.70108,https://pubmed.ncbi.nlm.nih.gov/42415513/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,42793752,&lt;i&gt;MCPH1&lt;/i&gt; and DNA Damage Response Pathway Genes as Candidate Susceptibility Loci in Hereditary Breast Cancer.,2026,10.3390/diagnostics16182967,https://pubmed.ncbi.nlm.nih.gov/42793752/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,42020761,Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation.,2026,10.1038/s41594-026-01796-6,https://pubmed.ncbi.nlm.nih.gov/42020761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,39153434,c-Myc-XRCC2-FOS axis promotes the proliferation and the resistance to Doxorubicin of NSCLC.,2024,10.1016/j.biopha.2024.117315,https://pubmed.ncbi.nlm.nih.gov/39153434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,38907095,PARP1 bound to XRCC2 promotes tumor progression in colorectal cancer.,2024,10.1007/s12672-024-01112-y,https://pubmed.ncbi.nlm.nih.gov/38907095/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,39206620,Screening of gastric cancer diagnostic biomarkers in the homologous recombination signaling pathway and assessment of their clinical and radiomic correlations.,2024,10.1002/cam4.70153,https://pubmed.ncbi.nlm.nih.gov/39206620/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,42682019,Distinct functions of mammalian RAD51 paralogs in genome maintenance.,2026,10.1042/bst20250440,https://pubmed.ncbi.nlm.nih.gov/42682019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,39048769,XRCC2 knockdown effectively sensitizes esophageal cancer to albumin-paclitaxel in vitro and in vivo.,2025,10.1007/s10528-024-10885-4,https://pubmed.ncbi.nlm.nih.gov/39048769/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,40719684,"Single-nucleotide polymorphisms in DNA repair genes &lt;i&gt;ERCC&lt;/i&gt;, &lt;i&gt;XRCC&lt;/i&gt;, and &lt;i&gt;MGMT&lt;/i&gt; and implications in glioblastoma: a pathway analysis and structural dynamics study.",2026,10.1080/07391102.2025.2534020,https://pubmed.ncbi.nlm.nih.gov/40719684/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,42772066,Whole-blood total chromium and DNA repair variation in an occupational Cr(VI)-exposure setting: Pathway-resolved associations across complementary response biomarkers.,2026,10.1016/j.jhazmat.2026.143665,https://pubmed.ncbi.nlm.nih.gov/42772066/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,42043168,"Oxidative Stress, DNA Damage, DNA Repair Inhibition, and Apoptosis Induced by Lead and Cadmium Combined Exposure in TK6 Cells.",2026,10.3390/toxics14040341,https://pubmed.ncbi.nlm.nih.gov/42043168/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,39731930,Discovery of novel xanthohumol C derivatives regulating XRCC2 transcription and expression for the treatment of colorectal cancer.,2025,10.1016/j.bmc.2024.118048,https://pubmed.ncbi.nlm.nih.gov/39731930/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,39733420,Genetic Polymorphisms of DNA Repair Genes and their Influence on Paclitaxel based Chemotherapy Induced Toxicity Reactions in Breast Cancer Patients.,2024,10.31557/apjcp.2024.25.12.4281,https://pubmed.ncbi.nlm.nih.gov/39733420/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,42281721,"Genetic Polymorphisms and Pesticide Exposure-Related Health Manifestations Among Grape Farmers in Maharashtra, India.",2026,10.7759/cureus.108637,https://pubmed.ncbi.nlm.nih.gov/42281721/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,40507362,The Impact of Genetic Variations on Radiotherapy Toxicity in Breast Cancer Patients: A Meta-Analysis of Acute and Late Skin Adverse Effects.,2025,10.3390/cancers17111880,https://pubmed.ncbi.nlm.nih.gov/40507362/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,40675964,Heat shock factor 1 promotes proliferation and chemoresistance in diffuse large B-cell lymphoma by enhancing the cell cycle and DNA repair.,2025,10.1038/s41419-025-07843-2,https://pubmed.ncbi.nlm.nih.gov/40675964/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,37774056,"Single Nucleotide Polymorphisms in DNA Repair Genes (XRCC1, XRCC2, XRCC3) and Their Association with Radiotherapy Toxicity among Head and Neck Cancer Patients:A Study from South-Western Maharashtra.",2023,10.31557/apjcp.2023.24.9.3049,https://pubmed.ncbi.nlm.nih.gov/37774056/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,39236027,Identifying crucial lncRNAs and mRNAs in hypoxia-induced A549 lung cancer cells and investigating their underlying mechanisms via high-throughput sequencing.,2024,10.1371/journal.pone.0307954,https://pubmed.ncbi.nlm.nih.gov/39236027/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,41526458,Whole genome sequencing approach to assess homologous recombination deficiency in a pan-cancer cohort.,2026,10.1038/s43856-025-01308-5,https://pubmed.ncbi.nlm.nih.gov/41526458/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,40670332,Comprehensive RAD51C ovarian cancer variant analysis uncouples homologous recombination and replicative functions.,2025,10.1038/s41467-025-61283-2,https://pubmed.ncbi.nlm.nih.gov/40670332/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,41053230,Integrated systems biology reveals an 8-gene signature predicting early-stage lung adenocarcinoma progression and patient survival.,2025,10.1038/s41598-025-18567-w,https://pubmed.ncbi.nlm.nih.gov/41053230/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,39421870,Somatic gene mutations involved in DNA damage response/Fanconi anemia signaling are tissue- and cell-type specific in human solid tumors.,2024,10.3389/fmed.2024.1462810,https://pubmed.ncbi.nlm.nih.gov/39421870/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,41088366,Exome sequencing reveals new insights into the germline landscape of inflammatory breast cancer among Tunisian patients.,2025,10.1186/s12967-025-07027-8,https://pubmed.ncbi.nlm.nih.gov/41088366/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,36761956,Relationship between polymorphisms in homologous recombination repair genes RAD51 G172T、XRCC2 & XRCC3 and risk of breast cancer: A meta-analysis.,2023,10.3389/fonc.2023.1047336,https://pubmed.ncbi.nlm.nih.gov/36761956/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC2,ENSG00000196584,Unsafe,34648414,XRCC2 Arg188His polymorphism and colorectal cancer risk: a meta-analysis.,2021,10.1177/03000605211039473,https://pubmed.ncbi.nlm.nih.gov/34648414/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,42255530,Evaluation of &lt;i&gt;XRCC4&lt;/i&gt; and &lt;i&gt;VEGF&lt;/i&gt; Gene Variants in Relation to Breast Cancer Risk in a Jordanian Cohort.,2026,10.2147/cmar.s595329,https://pubmed.ncbi.nlm.nih.gov/42255530/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,41813791,Deciphering novel genotypic biomarkers and functional alterations in double strand break repair pathways for Parkinson's disease.,2026,10.1038/s41598-026-43533-5,https://pubmed.ncbi.nlm.nih.gov/41813791/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,41513635,O-GlcNAcylation of XRCC4 controls its stability and confers resistance to DNA double-strand break damage in cancer cells.,2026,10.1038/s41419-025-08209-4,https://pubmed.ncbi.nlm.nih.gov/41513635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,41773020,Caffeine inhibits nonhomologous end joining by impairing ligase IV/XRCC4 function.,2026,10.1093/nar/gkag182,https://pubmed.ncbi.nlm.nih.gov/41773020/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,41399382,Integration of Single-cell and Bulk Transcriptome Analyses Unravels a Macrophage-based Gene Signature for Prognostication and Treatment in Triple-negative Breast Cancer.,2026,10.7150/ijms.120593,https://pubmed.ncbi.nlm.nih.gov/41399382/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,42297806,Systematic discovery of UFM1 receptors reveals a regulatory module in DNA repair directing non-homologous end-joining.,2026,10.1038/s41467-026-73882-8,https://pubmed.ncbi.nlm.nih.gov/42297806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,41599238,Impeding the NHEJ Pathway for Overcoming Radioresistance in the Context of Precision Radiotherapy of Cancer.,2026,10.3390/pharmaceutics18010131,https://pubmed.ncbi.nlm.nih.gov/41599238/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,41818715,Ultraviolet A plays a protective role in ultraviolet B-induced squamous cell carcinoma through c-Fos/XRCC4 axis.,2026,10.1093/carcin/bgag014,https://pubmed.ncbi.nlm.nih.gov/41818715/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,41728861,Association of &lt;i&gt;XRCC4&lt;/i&gt; and &lt;i&gt;XRCC5&lt;/i&gt; gene polymorphisms with polycystic ovarian syndrome in an Indian cohort.,2026,10.1080/17410541.2026.2634607,https://pubmed.ncbi.nlm.nih.gov/41728861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,40436899,Elevated nonhomologous end-joining by AATF enables efficient DNA damage repair and therapeutic resistance in glioblastoma.,2025,10.1038/s41467-025-60228-z,https://pubmed.ncbi.nlm.nih.gov/40436899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,40114033,"XRCC4-related microcephalic primordial dwarfism: description of a clinical series of 7 cases, phenotype expansion and new diagnostic approaches.",2025,10.1038/s41431-025-01821-0,https://pubmed.ncbi.nlm.nih.gov/40114033/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,41861660,Finely-tuned regulator of DNA repair: FBXW7-185aa may modulate glioblastoma radiosensitization and the tumor immune microenvironment.,2026,10.1016/j.tranon.2026.102733,https://pubmed.ncbi.nlm.nih.gov/41861660/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,41582583,Lactylation Plays a Novel Role in the Tumor Microenvironment and its Prognostic Implications for Breast Cancer.,2026,10.2174/0115748928413005251129104036,https://pubmed.ncbi.nlm.nih.gov/41582583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,41462961,Lactate Enhances Non-Homologous End Joining Repair and Chemoresistance Through Facilitating XRCC4-LIG4 Complex Assembly in Ovarian Cancer.,2025,10.3390/biomedicines13122949,https://pubmed.ncbi.nlm.nih.gov/41462961/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,42343416,Non-syndromic premature ovarian insufficiency associated with monoallelic LIG4 mutation via haploinsufficiency.,2026,10.1186/s13048-026-02163-1,https://pubmed.ncbi.nlm.nih.gov/42343416/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,41924615,TDP-43 related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review and narrative synthesis.,2026,10.3389/fnmol.2026.1671909,https://pubmed.ncbi.nlm.nih.gov/41924615/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,40826483,Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizophrenia.,2025,10.1186/s40779-025-00636-w,https://pubmed.ncbi.nlm.nih.gov/40826483/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,41616376,Machine Learning-Based Integrative Analysis Identifies SUMOylation-Related Genes Underlying the Immune Heterogeneity of Sepsis.,2026,10.1049/syb2.70053,https://pubmed.ncbi.nlm.nih.gov/41616376/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,39333437,Perspective in the Mechanisms for Repairing Sperm DNA Damage.,2025,10.1007/s43032-024-01714-5,https://pubmed.ncbi.nlm.nih.gov/39333437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,41298353,Polymerase theta repairs persistent G1-induced DNA breaks in S-phase during class switch recombination.,2025,10.1038/s41467-025-65555-9,https://pubmed.ncbi.nlm.nih.gov/41298353/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,41902554,An Update on Inborn Errors of V(D)J Recombination.,2026,10.1152/physiol.00004.2026,https://pubmed.ncbi.nlm.nih.gov/41902554/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,42822289,Cellular effects of silver diamine fluoride in oral cells.,2026,10.1016/j.job.2026.100821,https://pubmed.ncbi.nlm.nih.gov/42822289/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,42401588,The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells.,2026,10.1038/s41467-026-75271-7,https://pubmed.ncbi.nlm.nih.gov/42401588/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,36765282,Systematic analysis identifies XRCC4 as a potential immunological and prognostic biomarker associated with pan-cancer.,2023,10.1186/s12859-023-05165-8,https://pubmed.ncbi.nlm.nih.gov/36765282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,38793065,Molecular Profile of Important Genes for Radiogenomics in the Amazon Indigenous Population.,2024,10.3390/jpm14050484,https://pubmed.ncbi.nlm.nih.gov/38793065/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,38423600,"Non-homologous End-joining Genotype, mRNA Expression, and DNA Repair Capacity in Childhood Acute Lymphocytic Leukemia.",2024,10.21873/cgp.20436,https://pubmed.ncbi.nlm.nih.gov/38423600/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,39562655,EZH2 inhibition sensitizes MYC-high medulloblastoma cancers to PARP inhibition by regulating NUPR1-mediated DNA repair.,2025,10.1038/s41388-024-03232-9,https://pubmed.ncbi.nlm.nih.gov/39562655/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,38012734,Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer.,2023,10.1186/s13046-023-02854-3,https://pubmed.ncbi.nlm.nih.gov/38012734/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,35000298,Feline XRCC4 undergoes rapid Ku-dependent recruitment to DNA damage sites.,2022,10.1002/2211-5463.13363,https://pubmed.ncbi.nlm.nih.gov/35000298/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,33842963,Functional analysis of XRCC4 mutations in reported microcephaly and growth defect patients in terms of radiosensitivity.,2021,10.1093/jrr/rrab016,https://pubmed.ncbi.nlm.nih.gov/33842963/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
XRCC4,ENSG00000152422,Unsafe,8548796,The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination.,1995,10.1016/0092-8674(95)90135-3,https://pubmed.ncbi.nlm.nih.gov/8548796/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,42894271,A Pilot Randomized Study of NAT2 and YEATS4 Pharmacogenetic Return of Results in Adults with Hypertension and African Ancestry: The GUARDD-US PGx Study.,2026,10.1002/cpt.70527,https://pubmed.ncbi.nlm.nih.gov/42894271/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,41294372,Discovery and Development of a Small-Molecule Inhibitor Targeting the GAS41 YEATS Domain in Nonsmall Cell Lung Cancer.,2025,10.1021/acs.jmedchem.5c02307,https://pubmed.ncbi.nlm.nih.gov/41294372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,41475546,ANP32A-mediated histone 3 K27 acetylation is essential for sotorasib activity in KRAS-mutant non-small cell lung cancer.,2026,10.1016/j.jbc.2025.111110,https://pubmed.ncbi.nlm.nih.gov/41475546/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,41060805,YEATS4 reads histone crotonylation to promote fatty acid metabolism and cancer cell stemness.,2025,10.1016/j.celrep.2025.116400,https://pubmed.ncbi.nlm.nih.gov/41060805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,42745483,An H2A.Z-dependent epigenetic checkpoint in macrophages couples genetic risk to microbial metabolite signaling.,2026,10.1093/procel/pwag069,https://pubmed.ncbi.nlm.nih.gov/42745483/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,40707437,Strawberry notch 1 safeguards neuronal genome via regulation of Yeats4 expression.,2025,10.1038/s41420-025-02640-4,https://pubmed.ncbi.nlm.nih.gov/40707437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,40840014,High YEATS4 expression characterizes MDM2-amplified liposarcoma.,2025,10.1016/j.cancergen.2025.08.005,https://pubmed.ncbi.nlm.nih.gov/40840014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,40787449,Single-cell and spatial atlas of glioblastoma heterogeneity: characterizing the &lt;i&gt;PCLAF&lt;/i&gt;+ subtype and &lt;i&gt;YEATS4&lt;/i&gt;'s oncogenic role.,2025,10.3389/fimmu.2025.1614549,https://pubmed.ncbi.nlm.nih.gov/40787449/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,39788387,GAS41 promotes ITGA4-mediated PI3K/Akt/mTOR signaling pathway and glioma tumorigenesis.,2025,10.1016/j.bcp.2025.116747,https://pubmed.ncbi.nlm.nih.gov/39788387/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,41683873,Integrative Analysis of Placental Methylomes Identifies Epigenetically Regulated Genes Implicated in Fetal Growth Restriction.,2026,10.3390/ijms27031448,https://pubmed.ncbi.nlm.nih.gov/41683873/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,41094526,A human YEATS4 variant confers resistance to TST and IGRA conversion despite Mycobacterium tuberculosis exposure.,2025,10.1186/s13073-025-01547-0,https://pubmed.ncbi.nlm.nih.gov/41094526/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,42136307,The Enigma of Protein Succinylation in Diabetes.,2026,10.2174/0109298673447130260302035115,https://pubmed.ncbi.nlm.nih.gov/42136307/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,38514704,GAS41 modulates ferroptosis by anchoring NRF2 on chromatin.,2024,10.1038/s41467-024-46857-w,https://pubmed.ncbi.nlm.nih.gov/38514704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,38964523,YEATS domain-containing protein GAS41 regulates nuclear shape by working in concert with BRD2 and the mediator complex in colorectal cancer.,2024,10.1016/j.phrs.2024.107283,https://pubmed.ncbi.nlm.nih.gov/38964523/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,38526153,Targeting the KAT8/YEATS4 Axis Represses Tumor Growth and Increases Cisplatin Sensitivity in Bladder Cancer.,2024,10.1002/advs.202310146,https://pubmed.ncbi.nlm.nih.gov/38526153/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,42498900,Systems-level genomic analyses reveal shared mechanisms underlying endometriosis and sleep disorders.,2026,10.1007/s10142-026-01979-w,https://pubmed.ncbi.nlm.nih.gov/42498900/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,37435030,Mechanistic insights into genomic structure and functions of a novel oncogene YEATS4.,2023,10.3389/fcell.2023.1192139,https://pubmed.ncbi.nlm.nih.gov/37435030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,40643381,Development of Chemical Tools for the Human YEATS Domain.,2025,10.1021/acschembio.5c00349,https://pubmed.ncbi.nlm.nih.gov/40643381/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,37853482,Unveiling the role of GAS41 in cancer progression.,2023,10.1186/s12935-023-03098-z,https://pubmed.ncbi.nlm.nih.gov/37853482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,40971125,Learning from Yeast-How YEATS Domain Proteins Read Epigenetic Marks Driving Oncogenic Programs in Gastrointestinal Tumors.,2026,10.1007/s10620-025-09401-4,https://pubmed.ncbi.nlm.nih.gov/40971125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,40819401,The combined toxicity assessment of polystyrene microplastics and di(2-ethylhexyl) phthalate on cardiac development in zebrafish embryos.,2025,10.1016/j.ecoenv.2025.118867,https://pubmed.ncbi.nlm.nih.gov/40819401/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,40571889,Functional Roles and Mechanistic Insights of YEATS Domain Proteins in Digestive System Tumors.,2025,10.1007/s10620-025-09117-5,https://pubmed.ncbi.nlm.nih.gov/40571889/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,36562986,Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.,2023,10.1021/acs.jmedchem.2c01421,https://pubmed.ncbi.nlm.nih.gov/36562986/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,38564841,Therapeutic targeting of BET bromodomain and other epigenetic acetylrecognition domain-containing factors.,2024,10.1016/j.gde.2024.102181,https://pubmed.ncbi.nlm.nih.gov/38564841/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,34071920,"Multi-Institutional Implementation of Clinical Decision Support for APOL1, NAT2, and YEATS4 Genotyping in Antihypertensive Management.",2021,10.3390/jpm11060480,https://pubmed.ncbi.nlm.nih.gov/34071920/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,37289194,"Clinical and Genomic Characteristics of Patients with Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer Following Progression on Cyclin-Dependent Kinase 4 and 6 Inhibitors.",2023,10.1158/1078-0432.ccr-22-3843,https://pubmed.ncbi.nlm.nih.gov/37289194/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,33498189,Recent Advancement in Atypical Lipomatous Tumor Research.,2021,10.3390/ijms22030994,https://pubmed.ncbi.nlm.nih.gov/33498189/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,35279775,Multifaceted roles of YEATS domain-containing proteins and novel links to neurological diseases.,2022,10.1007/s00018-022-04218-0,https://pubmed.ncbi.nlm.nih.gov/35279775/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,31434684,Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription.,2019,10.1084/jem.20182363,https://pubmed.ncbi.nlm.nih.gov/31434684/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,30071723,GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode.,2018,10.1021/acschembio.8b00674,https://pubmed.ncbi.nlm.nih.gov/30071723/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,28445953,YEATS4 promotes the tumorigenesis of pancreatic cancer by activating beta-catenin/TCF signaling.,2017,10.18632/oncotarget.15633,https://pubmed.ncbi.nlm.nih.gov/28445953/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,22350108,Association of chromosome 12 locus with antihypertensive response to hydrochlorothiazide may involve differential YEATS4 expression.,2013,10.1038/tpj.2012.4,https://pubmed.ncbi.nlm.nih.gov/22350108/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,26874237,Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response.,2016,10.1016/j.coph.2016.01.005,https://pubmed.ncbi.nlm.nih.gov/26874237/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,29559929,Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder.,2018,10.3389/fpsyt.2018.00065,https://pubmed.ncbi.nlm.nih.gov/29559929/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,18591461,Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.,2008,10.1161/hypertensionaha.107.104273,https://pubmed.ncbi.nlm.nih.gov/18591461/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YEATS4,ENSG00000127337,Unsafe,10913114,"GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA.",2000,10.1074/jbc.m000994200,https://pubmed.ncbi.nlm.nih.gov/10913114/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,42726604,Exosomal miR-484 impairs CD8 &lt;sup&gt;+&lt;/sup&gt; T cell homeostasis in sepsis through the YPEL1/Cyclin E axis.,2026,10.3724/abbs.2026107,https://pubmed.ncbi.nlm.nih.gov/42726604/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,40103457,YPEL1 Inhibits Development of Gemcitabine Resistance in NK / T Cell Lymphomas.,2026,10.2174/0115680096328745250122231110,https://pubmed.ncbi.nlm.nih.gov/40103457/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,42378855,Development of a vitamin-related gene signature to predict the immune characteristics and prognosis of glioma.,2026,10.1016/j.bbrc.2026.154200,https://pubmed.ncbi.nlm.nih.gov/42378855/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,42404825,Yippee-like protein Moh1 links gene expression to metabolism and selective stress resistance in &lt;i&gt;Saccharomyces cerevisiae&lt;/i&gt;.,2026,10.15698/mic2026.06.881,https://pubmed.ncbi.nlm.nih.gov/42404825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,35185081,Yippee Like 1 Suppresses Glioma Progression and Serves as a Novel Prognostic Factor.,2022,10.1620/tjem.256.141,https://pubmed.ncbi.nlm.nih.gov/35185081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,41510081,Sarcopenia-driven gene model as a clinically actionable prognostic signature for head and neck squamous cell carcinoma.,2025,10.21037/tcr-2025-1310,https://pubmed.ncbi.nlm.nih.gov/41510081/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,35674183,Comprehensive analysis of the expression and prognosis of YPEL family members in clear cell renal cell cancer.,2022,10.3892/or.2022.8345,https://pubmed.ncbi.nlm.nih.gov/35674183/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,35706804,Bioinformatics analysis of potential glioblastoma circular RNA sponge network.,2022,10.21037/tcr-21-2597,https://pubmed.ncbi.nlm.nih.gov/35706804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,31558434,Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures.,2019,10.1242/dev.177428,https://pubmed.ncbi.nlm.nih.gov/31558434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,31599416,MiR-885-5p promotes gastric cancer proliferation and invasion through regulating YPEL1.,2019,10.26355/eurrev_201909_19005,https://pubmed.ncbi.nlm.nih.gov/31599416/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,31469246,Rare single-nucleotide variants in oculo-auriculo-vertebral spectrum (OAVS).,2019,10.1002/mgg3.959,https://pubmed.ncbi.nlm.nih.gov/31469246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,29221754,Up-regulation of YPEL1 and YPEL5 and down-regulation of ITGA2 in erlotinib-treated EGFR-mutant non-small cell lung cancer: A bioinformatic analysis.,2018,10.1016/j.gene.2017.12.003,https://pubmed.ncbi.nlm.nih.gov/29221754/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,27694906,CRISPR/Cas9 Targets Chicken Embryonic Somatic Cells In Vitro and In Vivo and generates Phenotypic Abnormalities.,2016,10.1038/srep34524,https://pubmed.ncbi.nlm.nih.gov/27694906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,26061551,YPEL1 overexpression in early avian craniofacial mesenchyme causes mandibular dysmorphogenesis by up-regulating apoptosis.,2015,10.1002/dvdy.24299,https://pubmed.ncbi.nlm.nih.gov/26061551/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,29344557,In colonic ρ0 (rho0) cells reduced mitochondrial function mediates transcriptomic alterations associated with cancer.,2017,10.18632/oncoscience.386,https://pubmed.ncbi.nlm.nih.gov/29344557/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,19893129,Expression of YPEL1 in pancreatic cancer cell lines and tissues.,2009,,https://pubmed.ncbi.nlm.nih.gov/19893129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,20388804,"YPEL3, a p53-regulated gene that induces cellular senescence.",2010,10.1158/0008-5472.can-09-3219,https://pubmed.ncbi.nlm.nih.gov/20388804/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,11473580,Ypel1: a novel nuclear protein that induces an epithelial-like morphology in fibroblasts.,2001,10.1046/j.1365-2443.2001.00445.x,https://pubmed.ncbi.nlm.nih.gov/11473580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
YPEL1,ENSG00000100027,Unsafe,15556292,Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species.,2004,10.1016/j.gene.2004.06.014,https://pubmed.ncbi.nlm.nih.gov/15556292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBBX,ENSG00000169064,Unsafe,39634417,Novel bioinformatic approaches show the role of driver genes in the progression of cervical cancer: An in-silico study.,2024,10.1016/j.heliyon.2024.e40179,https://pubmed.ncbi.nlm.nih.gov/39634417/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBBX,ENSG00000169064,Unsafe,33771330,An intrauterine genomic classifier reliably delineates the location of nonviable pregnancies.,2021,10.1016/j.fertnstert.2021.02.005,https://pubmed.ncbi.nlm.nih.gov/33771330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBBX,ENSG00000169064,Unsafe,29085643,Lumbosacral stenosis in Labrador retriever military working dogs - an exomic exploratory study.,2017,10.1186/s40575-017-0052-6,https://pubmed.ncbi.nlm.nih.gov/29085643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBBX,ENSG00000169064,Unsafe,21832240,Rare copy number variation discovery and cross-disorder comparisons identify risk genes for ADHD.,2011,10.1126/scitranslmed.3002464,https://pubmed.ncbi.nlm.nih.gov/21832240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,42551237,Establishing the role of ZBTB20 mutations in GnRH deficiency and impaired neurogenesis in the subventricular zone: a human cohort and animal model study.,2026,10.1016/j.ebiom.2026.106416,https://pubmed.ncbi.nlm.nih.gov/42551237/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,42905324,Upregulation of ZBTB20 indirectly participate in ferroptosis of Parkinson's disease by neuronal glial interactions.,2026,10.1007/s10863-026-10131-z,https://pubmed.ncbi.nlm.nih.gov/42905324/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,42741539,Integrated multi-omics analysis indicates MARCO and ZBTB20 as candidate biomarkers in rheumatoid arthritis and tuberculosis.,2026,10.3389/fimmu.2026.1886037,https://pubmed.ncbi.nlm.nih.gov/42741539/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,42912999,Histone methyltransferase NSD2 shapes CD8&lt;sup&gt;+&lt;/sup&gt; T cell fates through the H3K36me2-&lt;i&gt;Zbtb20&lt;/i&gt; axis.,2026,10.1126/sciadv.aee9670,https://pubmed.ncbi.nlm.nih.gov/42912999/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,41729076,Erythropoietin alleviates syndrome-associated intellectual disability and autism-like behavior in Zbtb20-haploinsufficient Primrose syndrome mouse model.,2026,10.1172/jci.insight.200021,https://pubmed.ncbi.nlm.nih.gov/41729076/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,41954169,miR-221 Mediates the Regulation of Phospholamban Expression and Cardiac Contractility by ZBTB20.,2026,10.1111/apha.70217,https://pubmed.ncbi.nlm.nih.gov/41954169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,40999982,ZBTB20 promotes ferroptosis through inhibiting TMEM109 expression in glioblastoma cells.,2025,10.3892/ijo.2025.5803,https://pubmed.ncbi.nlm.nih.gov/40999982/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,41294801,Roquin Modulates Cardiac Post-Infarct Remodeling via microRNA Stability Control.,2025,10.3390/cells14221748,https://pubmed.ncbi.nlm.nih.gov/41294801/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,41739993,Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression.,2026,10.1002/advs.202520917,https://pubmed.ncbi.nlm.nih.gov/41739993/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,40948117,ZBTB20 Regulating Postnatal Articular Cartilage Development and Homeostasis: Implications for Early-Onset Osteoarthritis.,2026,10.1002/art.43393,https://pubmed.ncbi.nlm.nih.gov/40948117/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,41485060,KRAS-ERK signaling drives metastasis in colorectal cancer via phosphorylation-dependent activation of the ZBTB20-TGFBR2 axis.,2026,10.1186/s13046-025-03619-w,https://pubmed.ncbi.nlm.nih.gov/41485060/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,42919401,Expression and clinical significance of miR-34a-5p in lumbar disc herniation.,2026,10.1186/s13018-026-07131-5,https://pubmed.ncbi.nlm.nih.gov/42919401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,42783847,Genetic Determinants of Tau-PET Imaging in Alzheimer's Disease: A Narrative Review of Genome-Wide and Candidate-Gene Studies.,2026,10.3390/jimaging12090423,https://pubmed.ncbi.nlm.nih.gov/42783847/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,41057875,Overexpression of CCK Neuropeptide in brain is linked to ZBTB20 mutations: potential diagnostic relevance in glioblastoma.,2025,10.1186/s12920-025-02218-0,https://pubmed.ncbi.nlm.nih.gov/41057875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,42218498,Network-based single-cell analysis identifies a proliferative GZMB&lt;sup&gt;+&lt;/sup&gt; plasma cell subset linked to Hedgehog signaling and prognostic risk in lung squamous cell carcinoma.,2026,10.1186/s12967-026-08328-2,https://pubmed.ncbi.nlm.nih.gov/42218498/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,42609474,Seasonal metabolic oscillation: adiposity cycling as a candidate amplifier of mood seasonality in seasonal affective and bipolar disorders.,2026,10.3389/fpsyt.2026.1921655,https://pubmed.ncbi.nlm.nih.gov/42609474/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,41614210,ZBTB20 coordinates the proliferation-differentiation switch of incisor epithelial progenitor cells.,2026,10.1242/dev.205250,https://pubmed.ncbi.nlm.nih.gov/41614210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,41627248,Coordination and oxidation properties of ZBTB20: CX&lt;sub&gt;2&lt;/sub&gt;CX&lt;sub&gt;12&lt;/sub&gt;HX&lt;sub&gt;3&lt;/sub&gt;H-type zinc fingers.,2026,10.1039/d5dt02032h,https://pubmed.ncbi.nlm.nih.gov/41627248/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,40497236,Regulation of carcinogenesis through multiple zinc fingers in ZBTB20.,2025,10.1039/d5cb00088b,https://pubmed.ncbi.nlm.nih.gov/40497236/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,42054349,Whole transcriptome sequencing and ceRNA regulation network profiling of heat acclimation in protecting against heat stress injury in rat myocardium.,2026,10.1371/journal.pone.0348180,https://pubmed.ncbi.nlm.nih.gov/42054349/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,40580873,Identification and validation of synergistic drug strategies targeting macrophage polarization in triple-negative breast cancer via single-cell transcriptomics and deep learning.,2025,10.1016/j.tranon.2025.102457,https://pubmed.ncbi.nlm.nih.gov/40580873/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,40494351,Structural insights into ZBTB20 action at the AFP promoter.,2025,10.1016/j.str.2025.05.009,https://pubmed.ncbi.nlm.nih.gov/40494351/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,41120125,SPP1&lt;sup&gt;high&lt;/sup&gt; macrophage-induced T-cell stress promotes colon cancer liver metastasis through SPP1/CD44/PI3K/AKT signaling.,2025,10.1136/jitc-2025-012330,https://pubmed.ncbi.nlm.nih.gov/41120125/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,41807965,Integrated single-cell and spatial transcriptomic analysis reveals mCAF-SPP1⁺ macrophage-T cell crosstalk shaping immunosuppressive niches in colorectal cancer liver metastasis.,2026,10.1186/s12967-026-07978-6,https://pubmed.ncbi.nlm.nih.gov/41807965/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,40069162,LATS1-modulated ZBTB20 perturbing cartilage matrix homeostasis contributes to early-stage osteoarthritis.,2025,10.1038/s41413-025-00414-3,https://pubmed.ncbi.nlm.nih.gov/40069162/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,41817300,Single-Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota.,2026,10.1002/eji.70170,https://pubmed.ncbi.nlm.nih.gov/41817300/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,38397429,Zinc Finger and BTB Domain-Containing 20: A Newly Emerging Player in Pathogenesis and Development of Human Cancers.,2024,10.3390/biom14020192,https://pubmed.ncbi.nlm.nih.gov/38397429/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,40570375,Gene-regulatory programs that specify age-related differences during thymocyte development.,2025,10.1016/j.celrep.2025.115903,https://pubmed.ncbi.nlm.nih.gov/40570375/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,37414528,Characterizing control of memory CD8 T cell differentiation by BTB-ZF transcription factor Zbtb20.,2023,10.26508/lsa.202201683,https://pubmed.ncbi.nlm.nih.gov/37414528/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,40027481,"Cross-tissue multi-omics analyses reveal the gut microbiota's absence impacts organ morphology, immune homeostasis, bile acid and lipid metabolism.",2025,10.1002/imt2.272,https://pubmed.ncbi.nlm.nih.gov/40027481/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,40348204,An analysis of prognostic risk and immunotherapy response of glioblastoma patients based on single-cell landscape and nitrogen metabolism.,2025,10.1016/j.nbd.2025.106935,https://pubmed.ncbi.nlm.nih.gov/40348204/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,35522722,Zbtb20 identifies and controls a thymus-derived population of regulatory T cells that play a role in intestinal homeostasis.,2022,10.1126/sciimmunol.abf3717,https://pubmed.ncbi.nlm.nih.gov/35522722/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB20,ENSG00000181722,Unsafe,11352661,"Identification and characterization of DPZF, a novel human BTB/POZ zinc finger protein sharing homology to BCL-6.",2001,10.1006/bbrc.2001.4689,https://pubmed.ncbi.nlm.nih.gov/11352661/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB3,ENSG00000185670,Unsafe,40814367,Erratum: SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer.,2025,10.62347/ivfl8331,https://pubmed.ncbi.nlm.nih.gov/40814367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB3,ENSG00000185670,Unsafe,39264467,Identifying hub genes for chemo-radiotherapy sensitivity in cervical cancer: a bi-dataset in silico analysis.,2024,10.1007/s12672-024-01328-y,https://pubmed.ncbi.nlm.nih.gov/39264467/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB3,ENSG00000185670,Unsafe,42132448,"Toward multimodal integration of colorectal cancer and chronic kidney disease: transcriptomic modeling as a framework for the SIRIO study ""Spatial radiomics and transcriptomics to the discovery of the cross-link between colon cancer and chronic kidney disease"".",2026,10.2478/raon-2026-0026,https://pubmed.ncbi.nlm.nih.gov/42132448/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB3,ENSG00000185670,Unsafe,36869052,An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping.,2023,10.1038/s41467-023-36897-z,https://pubmed.ncbi.nlm.nih.gov/36869052/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB3,ENSG00000185670,Unsafe,38285876,Cellular origin and molecular mechanisms of lung metastases in patients with aggressive hepatoblastoma.,2024,10.1097/hc9.0000000000000369,https://pubmed.ncbi.nlm.nih.gov/38285876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB3,ENSG00000185670,Unsafe,31911863,SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer.,2019,,https://pubmed.ncbi.nlm.nih.gov/31911863/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB3,ENSG00000185670,Unsafe,36245280,Integrative Functional Genomics Identifies Systemic Lupus Erythematosus Causal Genetic Variant in the IRF5 Risk Locus.,2023,10.1002/art.42390,https://pubmed.ncbi.nlm.nih.gov/36245280/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB3,ENSG00000185670,Unsafe,29535137,LncKdm2b controls self-renewal of embryonic stem cells via activating expression of transcription factor Zbtb3.,2018,10.15252/embj.201797174,https://pubmed.ncbi.nlm.nih.gov/29535137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB3,ENSG00000185670,Unsafe,24856827,Zinc finger and BTB domain-containing protein 3 is essential for the growth of cancer cells.,2014,10.5483/bmbrep.2014.47.7.075,https://pubmed.ncbi.nlm.nih.gov/24856827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB3,ENSG00000185670,Unsafe,29997306,Transcript Profiling Identifies Early Response Genes against FMDV Infection in PK-15 Cells.,2018,10.3390/v10070364,https://pubmed.ncbi.nlm.nih.gov/29997306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB3,ENSG00000185670,Unsafe,23031785,A genome-wide signature of glucocorticoid receptor binding in neuronal PC12 cells.,2012,10.1186/1471-2202-13-118,https://pubmed.ncbi.nlm.nih.gov/23031785/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB3,ENSG00000185670,Unsafe,21904435,Remote homologue identification of Drosophila GAGA factor in mouse.,2011,10.6026/97320630007029,https://pubmed.ncbi.nlm.nih.gov/21904435/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB3,ENSG00000185670,Unsafe,25205108,The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.,2015,10.1093/hmg/ddu455,https://pubmed.ncbi.nlm.nih.gov/25205108/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB3,ENSG00000185670,Unsafe,23525215,Two populations of glucocorticoid receptor-binding sites in the male rat hippocampal genome.,2013,10.1210/en.2012-2187,https://pubmed.ncbi.nlm.nih.gov/23525215/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,41649522,Zbtb32 promotes CD8+ T cell differentiation and function in cancer.,2026,10.1084/jem.20250005,https://pubmed.ncbi.nlm.nih.gov/41649522/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,41947764,Distinct Inflammatory Programming of Thoracic Cavity White Adipose Immune Cells Regulates Influenza Pathogenesis.,2026,10.1093/infdis/jiag201,https://pubmed.ncbi.nlm.nih.gov/41947764/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,41817300,Single-Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota.,2026,10.1002/eji.70170,https://pubmed.ncbi.nlm.nih.gov/41817300/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,36348719,Suppression of the Testis-Specific Transcription of the ZBTB32 and ZNF473 Genes in Germ Cell Tumors.,2022,10.32607/actanaturae.11620,https://pubmed.ncbi.nlm.nih.gov/36348719/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,41556164,Deciphering CD4+ Naive T cell-mediated divergent pathogenic links between type 2 diabetes and pathologic scarring via an integrated multi-omics approach.,2026,10.1097/js9.0000000000004905,https://pubmed.ncbi.nlm.nih.gov/41556164/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,40489024,Single-cell transcriptomic profiling reveals dysregulation of B-cell subset function in patients with chronic hepatitis B.,2025,10.1007/s12072-025-10846-y,https://pubmed.ncbi.nlm.nih.gov/40489024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,34337361,ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation.,2021,10.1016/j.isci.2021.102790,https://pubmed.ncbi.nlm.nih.gov/34337361/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,38873823,CD147-K148me2-Driven Tumor Cell-Macrophage Crosstalk Provokes NSCLC Immunosuppression via the CCL5/CCR5 Axis.,2024,10.1002/advs.202400611,https://pubmed.ncbi.nlm.nih.gov/38873823/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,24747678,The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection.,2014,10.1038/ni.2876,https://pubmed.ncbi.nlm.nih.gov/24747678/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,35095893,N6-Methyladenosine-Related LncRNAs Are Potential Remodeling Indicators in the Tumor Microenvironment and Prognostic Markers in Osteosarcoma.,2021,10.3389/fimmu.2021.806189,https://pubmed.ncbi.nlm.nih.gov/35095893/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,31649328,"ZBTB32 restrains antibody responses to murine cytomegalovirus infections, but not other repetitive challenges.",2019,10.1038/s41598-019-51860-z,https://pubmed.ncbi.nlm.nih.gov/31649328/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,23634227,Tzfp represses the androgen receptor in mouse testis.,2013,10.1371/journal.pone.0062314,https://pubmed.ncbi.nlm.nih.gov/23634227/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,32457837,Identification of a Splenic Marginal Zone Lymphoma Signature: Preliminary Findings With Diagnostic Potential.,2020,10.3389/fonc.2020.00640,https://pubmed.ncbi.nlm.nih.gov/32457837/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,36871085,Upregulation of host genes during disease progression in bovine leukemia virus infection is independent of overexpression of viral transcriptional regulators in vitro.,2023,10.1007/s00705-023-05713-w,https://pubmed.ncbi.nlm.nih.gov/36871085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,28827827,Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory.,2017,10.1371/journal.ppat.1006544,https://pubmed.ncbi.nlm.nih.gov/28827827/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,34869316,Fanconi Anemia Pathway Genes Advance Cervical Cancer via Immune Regulation and Cell Adhesion.,2021,10.3389/fcell.2021.734794,https://pubmed.ncbi.nlm.nih.gov/34869316/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,29707204,Loss of Zbtb32 in NOD mice does not significantly alter T cell responses.,2018,10.12688/f1000research.13864.2,https://pubmed.ncbi.nlm.nih.gov/29707204/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,27357154,ZBTB32 Restricts the Duration of Memory B Cell Recall Responses.,2016,10.4049/jimmunol.1600882,https://pubmed.ncbi.nlm.nih.gov/27357154/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,29616049,Regulation of the Development and Function of B Cells by ZBTB Transcription Factors.,2018,10.3389/fimmu.2018.00580,https://pubmed.ncbi.nlm.nih.gov/29616049/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,22965116,Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes.,2012,10.1093/nar/gks839,https://pubmed.ncbi.nlm.nih.gov/22965116/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,26070317,DCIR2+ cDC2 DCs and Zbtb32 Restore CD4+ T-Cell Tolerance and Inhibit Diabetes.,2015,10.2337/db14-1880,https://pubmed.ncbi.nlm.nih.gov/26070317/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,29858012,Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response.,2018,10.1016/j.immuni.2018.04.018,https://pubmed.ncbi.nlm.nih.gov/29858012/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,32956421,ZBTB38 is dispensable for antibody responses.,2020,10.1371/journal.pone.0235183,https://pubmed.ncbi.nlm.nih.gov/32956421/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,22851713,ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells.,2012,10.4049/jimmunol.1103371,https://pubmed.ncbi.nlm.nih.gov/22851713/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,26481684,Oct1 and OCA-B are selectively required for CD4 memory T cell function.,2015,10.1084/jem.20150363,https://pubmed.ncbi.nlm.nih.gov/26481684/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB32,ENSG00000011590,Unsafe,10544010,"Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP.",1999,10.1006/bbrc.1999.1594,https://pubmed.ncbi.nlm.nih.gov/10544010/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB37,ENSG00000185278,Unsafe,36791943,Suppression of innate and acquired immunity in severe hand foot and mouth disease caused by EV71 infections in children.,2023,10.1016/j.clim.2023.109260,https://pubmed.ncbi.nlm.nih.gov/36791943/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB37,ENSG00000185278,Unsafe,36121009,Individual differences in cocaine-induced conditioned place preference in male rats: Behavioral and transcriptomic evidence.,2022,10.1177/02698811221123047,https://pubmed.ncbi.nlm.nih.gov/36121009/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB37,ENSG00000185278,Unsafe,35761863,Integrated Multi-Omics Analysis Model to Identify Biomarkers Associated With Prognosis of Breast Cancer.,2022,10.3389/fonc.2022.899900,https://pubmed.ncbi.nlm.nih.gov/35761863/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB37,ENSG00000185278,Unsafe,34513699,Construction and Characterization of Long Non-Coding RNA-Associated Networks to Reveal Potential Prognostic Biomarkers in Human Lung Adenocarcinoma.,2021,10.3389/fonc.2021.720400,https://pubmed.ncbi.nlm.nih.gov/34513699/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB37,ENSG00000185278,Unsafe,26208102,Deficiency in Aryl Hydrocarbon Receptor (AHR) Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem Cells.,2015,10.1371/journal.pone.0133791,https://pubmed.ncbi.nlm.nih.gov/26208102/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB8A,ENSG00000160062,Unsafe,40148429,Exploring the polygenic landscape of wool traits in Turkish Merinos through multi-locus GWAS approaches: middle Anatolian Merino.,2025,10.1038/s41598-025-95099-3,https://pubmed.ncbi.nlm.nih.gov/40148429/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB8A,ENSG00000160062,Unsafe,40500699,Genomic analysis association of tolerance to heat stress in subtropical Egyptian goats Raised in hot dry environment.,2025,10.1186/s12864-025-11748-x,https://pubmed.ncbi.nlm.nih.gov/40500699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB8A,ENSG00000160062,Unsafe,23329847,Regulation of the cyclin-dependent kinase inhibitor 1A gene (CDKN1A) by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding.,2013,10.1074/jbc.m112.416297,https://pubmed.ncbi.nlm.nih.gov/23329847/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB8A,ENSG00000160062,Unsafe,24369406,[Expression of ZBTB8A in gastric cancer and its clinical significance].,2013,,https://pubmed.ncbi.nlm.nih.gov/24369406/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB9,ENSG00000213588,Unsafe,39542250,Cell-state-dependent regulation of PPARγ signaling by the transcription factor ZBTB9 in adipocytes.,2024,10.1016/j.jbc.2024.107985,https://pubmed.ncbi.nlm.nih.gov/39542250/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB9,ENSG00000213588,Unsafe,36522647,Identification of ZBTB9 as a potential therapeutic target against dysregulation of tumor cells proliferation and a novel biomarker in Liver Hepatocellular Carcinoma.,2022,10.1186/s12967-022-03790-0,https://pubmed.ncbi.nlm.nih.gov/36522647/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB9,ENSG00000213588,Unsafe,35732899,CF-PPiD technology based on cell-free protein array and proximity biotinylation enzyme for in vitro direct interactome analysis.,2022,10.1038/s41598-022-14872-w,https://pubmed.ncbi.nlm.nih.gov/35732899/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB9,ENSG00000213588,Unsafe,26805783,Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans.,2016,10.1016/j.ajhg.2015.12.003,https://pubmed.ncbi.nlm.nih.gov/26805783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZBTB9,ENSG00000213588,Unsafe,29037440,Novel genetic loci associated HLA-B*08:01 positive myasthenia gravis.,2018,10.1016/j.jaut.2017.10.002,https://pubmed.ncbi.nlm.nih.gov/29037440/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZC2HC1C,ENSG00000119703,Unsafe,40282865,Investigating the Role of the Zinc Finger Protein ZC2HC1C on Autism Spectrum Disorder Susceptibility.,2025,10.3390/medicina61040574,https://pubmed.ncbi.nlm.nih.gov/40282865/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZC2HC1C,ENSG00000119703,Unsafe,40943169,Genome-Wide Association Studies in Japanese Quails of the F&lt;sub&gt;2&lt;/sub&gt; Resource Population Elucidate Molecular Markers and Candidate Genes for Body Weight Parameters.,2025,10.3390/ijms26178243,https://pubmed.ncbi.nlm.nih.gov/40943169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZC2HC1C,ENSG00000119703,Unsafe,39859203,Onvansertib and Navitoclax Combination as a New Therapeutic Option for Mucinous Ovarian Carcinoma.,2025,10.3390/ijms26020472,https://pubmed.ncbi.nlm.nih.gov/39859203/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZC2HC1C,ENSG00000119703,Unsafe,36193031,Screening of candidate genes at GLC3B and GLC3C loci in Chinese primary congenital glaucoma patients with targeted next generation sequencing.,2023,10.1080/13816810.2022.2109683,https://pubmed.ncbi.nlm.nih.gov/36193031/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZC2HC1C,ENSG00000119703,Unsafe,29073243,"RNA-seq transcriptome analysis of formalin fixed, paraffin-embedded canine meningioma.",2017,10.1371/journal.pone.0187150,https://pubmed.ncbi.nlm.nih.gov/29073243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,41574437,A novel dual histone mark reader ZCWPW2 regulates meiotic recombination through lactylation and transcriptional regulation in humans and mice.,2026,10.1093/nar/gkag049,https://pubmed.ncbi.nlm.nih.gov/41574437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,38310235,A loss-of-function variant in ZCWPW1 causes human male infertility with sperm head defect and high DNA fragmentation.,2024,10.1186/s12978-024-01746-9,https://pubmed.ncbi.nlm.nih.gov/38310235/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,39732722,scRNA + BCR-seq identifies proportions and characteristics of dual BCR B cells in the peritoneal cavity of mice and peripheral blood of healthy human donors across different ages.,2024,10.1186/s12979-024-00493-6,https://pubmed.ncbi.nlm.nih.gov/39732722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,39069129,Identification of Novel Prognostic Signature of Recurrent Low-Grade Glioma.,2024,10.1016/j.wneu.2024.07.147,https://pubmed.ncbi.nlm.nih.gov/39069129/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,39791560,Maternal Exposure to Polystyrene Nanoplastics Disrupts Spermatogenesis in Mouse Offspring by Inducing Prdm14 Overexpression in Undifferentiated Spermatogonia.,2025,10.1021/acsnano.4c10701,https://pubmed.ncbi.nlm.nih.gov/39791560/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,32744506,ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair.,2020,10.7554/elife.53392,https://pubmed.ncbi.nlm.nih.gov/32744506/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,38527854,Connecting dementia risk loci to the CSF proteome identifies pathophysiological leads for dementia.,2024,10.1093/brain/awae090,https://pubmed.ncbi.nlm.nih.gov/38527854/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,35217607,PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2.,2022,10.1073/pnas.2114401119,https://pubmed.ncbi.nlm.nih.gov/35217607/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,37315217,MiR-5622-3p inhibits ZCWPW1 to induce apoptosis in silica-exposed mice and spermatocyte cells.,2023,10.1080/17435390.2023.2223632,https://pubmed.ncbi.nlm.nih.gov/37315217/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,31453335,The histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice.,2019,10.1126/sciadv.aax1101,https://pubmed.ncbi.nlm.nih.gov/31453335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,38473892,Exploring the Genetic Landscape of Mild Behavioral Impairment as an Early Marker of Cognitive Decline: An Updated Review Focusing on Alzheimer's Disease.,2024,10.3390/ijms25052645,https://pubmed.ncbi.nlm.nih.gov/38473892/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,36068616,The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.,2022,10.1186/s13059-022-02758-z,https://pubmed.ncbi.nlm.nih.gov/36068616/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,32352380,Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice.,2020,10.7554/elife.53360,https://pubmed.ncbi.nlm.nih.gov/32352380/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,32374261,The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair.,2020,10.7554/elife.53459,https://pubmed.ncbi.nlm.nih.gov/32374261/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,33257503,Prediction and Validation of Mouse Meiosis-Essential Genes Based on Spermatogenesis Proteome Dynamics.,2021,10.1074/mcp.ra120.002081,https://pubmed.ncbi.nlm.nih.gov/33257503/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,36411364,Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease.,2022,10.1038/s41588-022-01208-7,https://pubmed.ncbi.nlm.nih.gov/36411364/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,26004081,"Alzheimer disease (AD) specific transcription, DNA methylation and splicing in twenty AD associated loci.",2015,10.1016/j.mcn.2015.05.003,https://pubmed.ncbi.nlm.nih.gov/26004081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,26958812,ZCWPW1 is associated with late-onset Alzheimer's disease in Han Chinese: a replication study and meta-analyses.,2016,10.18632/oncotarget.7945,https://pubmed.ncbi.nlm.nih.gov/26958812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,26919393,Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.,2016,10.1371/journal.pone.0148717,https://pubmed.ncbi.nlm.nih.gov/26919393/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,27066552,Late-onset Alzheimer disease risk variants mark brain regulatory loci.,2015,10.1212/nxg.0000000000000012,https://pubmed.ncbi.nlm.nih.gov/27066552/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,28054028,The effect of the top 20 Alzheimer disease risk genes on gray-matter density and FDG PET brain metabolism.,2016,10.1016/j.dadm.2016.12.003,https://pubmed.ncbi.nlm.nih.gov/28054028/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,29885764,A Longitudinal Imaging Genetics Study of Neuroanatomical Asymmetry in Alzheimer's Disease.,2018,10.1016/j.biopsych.2018.04.017,https://pubmed.ncbi.nlm.nih.gov/29885764/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,27849641,Genetic Comparison of Symptomatic and Asymptomatic Persons With Alzheimer Disease Neuropathology.,2017,10.1097/wad.0000000000000179,https://pubmed.ncbi.nlm.nih.gov/27849641/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,24951455,Alzheimer's disease risk genes and mechanisms of disease pathogenesis.,2015,10.1016/j.biopsych.2014.05.006,https://pubmed.ncbi.nlm.nih.gov/24951455/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,24829845,Late-Onset Alzheimer's Disease Genes and the Potentially Implicated Pathways.,2014,10.1007/s40142-014-0034-x,https://pubmed.ncbi.nlm.nih.gov/24829845/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZCWPW1,ENSG00000078487,Unsafe,27371493,Relation of genomic variants for Alzheimer disease dementia to common neuropathologies.,2016,10.1212/wnl.0000000000002909,https://pubmed.ncbi.nlm.nih.gov/27371493/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,42533371,Adipocyte-Derived Palmitic Acid Promotes Breast Cancer Malignancy via ZDHHC15-Mediated S-Palmitoylation of PPARγ.,2026,10.1111/cas.70487,https://pubmed.ncbi.nlm.nih.gov/42533371/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,42900420,GSDMD palmitoylation induces acinar cell pyroptosis via promoting GSDMD-N oligomerization to aggravate hyperlipidemic acute pancreatitis.,2026,10.1007/s13105-026-01247-2,https://pubmed.ncbi.nlm.nih.gov/42900420/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,40207776,S-palmitoylation of c-MET by CK2α-mediated zDHHC15 phosphorylation drives glioblastoma stem cell tumorigenicity.,2025,10.1093/neuonc/noaf098,https://pubmed.ncbi.nlm.nih.gov/40207776/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,39686664,Dietary Palmitic Acid Drives a Palmitoyltransferase ZDHHC15-YAP Feedback Loop Promoting Tumor Metastasis.,2025,10.1002/advs.202409883,https://pubmed.ncbi.nlm.nih.gov/39686664/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,41209464,Transcriptomic analysis revealed that oar-miR-370-3p was involved in the regulation of wool fineness in Ordos fine-wool sheep.,2025,10.3389/fvets.2025.1662962,https://pubmed.ncbi.nlm.nih.gov/41209464/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,37161425,ZDHHC15 promotes glioma malignancy and acts as a novel prognostic biomarker for patients with glioma.,2023,10.1186/s12885-023-10883-6,https://pubmed.ncbi.nlm.nih.gov/37161425/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,41581876,In vitro reconstitution in membrane environment reveals critical lipid dependence of substrate S-acylation by protein palmitoyltransferase enzymes.,2026,10.1016/j.jbc.2026.111194,https://pubmed.ncbi.nlm.nih.gov/41581876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,33541421,Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.,2021,10.1186/s13287-021-02175-2,https://pubmed.ncbi.nlm.nih.gov/33541421/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,36565021,ZDHHC15 as a candidate gene for autism spectrum disorder.,2023,10.1002/ajmg.a.63099,https://pubmed.ncbi.nlm.nih.gov/36565021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,41116964,Construction and validation of a novel diagnostic model with palmitoylation-related genes for prostate cancer.,2025,10.1007/s10616-025-00842-3,https://pubmed.ncbi.nlm.nih.gov/41116964/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,33462194,"Increased novelty-induced locomotion, sensitivity to amphetamine, and extracellular dopamine in striatum of Zdhhc15-deficient mice.",2021,10.1038/s41398-020-01194-6,https://pubmed.ncbi.nlm.nih.gov/33462194/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,34345675,"Mutation in ZDHHC15 Leads to Hypotonic Cerebral Palsy, Autism, Epilepsy, and Intellectual Disability.",2021,10.1212/nxg.0000000000000602,https://pubmed.ncbi.nlm.nih.gov/34345675/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,37010951,Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases.,2023,10.7554/elife.83217,https://pubmed.ncbi.nlm.nih.gov/37010951/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,35664705,Palmitoyl transferases act as potential regulators of tumor-infiltrating immune cells and glioma progression.,2022,10.1016/j.omtn.2022.04.030,https://pubmed.ncbi.nlm.nih.gov/35664705/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,31189538,Regulation of dendrite morphology and excitatory synapse formation by zDHHC15.,2019,10.1242/jcs.230052,https://pubmed.ncbi.nlm.nih.gov/31189538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,34616429,Intelligence Quotient Variability in Klinefelter Syndrome Is Associated With GTPBP6 Expression Under Regulation of X-Chromosome Inactivation Pattern.,2021,10.3389/fgene.2021.724625,https://pubmed.ncbi.nlm.nih.gov/34616429/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,36926587,Genome-wide association study to identify SNPs and candidate genes associated with body size traits in donkeys.,2023,10.3389/fgene.2023.1112377,https://pubmed.ncbi.nlm.nih.gov/36926587/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,25742136,Dysregulation of X chromosome inactivation in high grade ovarian serous adenocarcinoma.,2015,10.1371/journal.pone.0118927,https://pubmed.ncbi.nlm.nih.gov/25742136/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,26290131,X-linked intellectual disability related genes disrupted by balanced X-autosome translocations.,2015,10.1002/ajmg.b.32355,https://pubmed.ncbi.nlm.nih.gov/26290131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,25747126,Genetic mechanisms leading to primary amenorrhea in balanced X-autosome translocations.,2015,10.1016/j.fertnstert.2015.01.030,https://pubmed.ncbi.nlm.nih.gov/25747126/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,42843329,Targeting ZDHHC15-mediated S-acylation of CD155 reactivates anti-tumor immunity.,2026,10.1016/j.chembiol.2026.09.006,https://pubmed.ncbi.nlm.nih.gov/42843329/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC15,ENSG00000102383,Unsafe,15915161,Loss of ZDHHC15 expression in a woman with a balanced translocation t(X;15)(q13.3;cen) and severe mental retardation.,2005,10.1038/sj.ejhg.5201445,https://pubmed.ncbi.nlm.nih.gov/15915161/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,41105761,Palmitoyltransferase ZDHHC19 regulates histone-to-protamine exchange during spermiogenesis in mice.,2025,10.1126/sciadv.adv5189,https://pubmed.ncbi.nlm.nih.gov/41105761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,42504267,Zinc finger DHHC-type containing 19 promotes retinal pigment epithelium cell proliferation via VEGFA palmitoylation in diabetic macular edema (DME).,2026,10.1007/s40200-026-02023-1,https://pubmed.ncbi.nlm.nih.gov/42504267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,40030029,TEX38 localizes ZDHHC19 to the plasma membrane and regulates sperm head morphogenesis in mice.,2025,10.1073/pnas.2417943122,https://pubmed.ncbi.nlm.nih.gov/40030029/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,40282319,Co-Expression Analysis of the ZDHHC19 Palmitoyltransferase-miR-4733-miR-596 Putative Regulatory Axis in Sepsis.,2025,10.3390/genes16040359,https://pubmed.ncbi.nlm.nih.gov/40282319/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,40666706,Immune Dysregulation and Prognosis in Sepsis: Insights From a Posttranslational Perspective.,2025,10.1155/humu/5503939,https://pubmed.ncbi.nlm.nih.gov/40666706/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,41350894,Polydatin upregulates ZDHHC19 to promote apoptosis of acute myeloid leukemia cells via mediating BID palmitoylation.,2025,10.1186/s12964-025-02579-0,https://pubmed.ncbi.nlm.nih.gov/41350894/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,41734583,Single-cell transcriptomics reveals phenotypic and functional alterations of erythroid progenitor cells in tuberculosis patients.,2026,10.1016/j.tube.2026.102746,https://pubmed.ncbi.nlm.nih.gov/41734583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,34445597,"ZDHHC19 Is Dispensable for Spermatogenesis, but Is Essential for Sperm Functions in Mice.",2021,10.3390/ijms22168894,https://pubmed.ncbi.nlm.nih.gov/34445597/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,42803173,Multi-omics Analysis of the Palmitoylation Gene ZDHHC18 Regulating Sphingolipid Metabolic Homeostasis and Its Role in Epilepsy Pathogenesis.,2026,10.2174/0109298673430980260107111800,https://pubmed.ncbi.nlm.nih.gov/42803173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,41465920,Causal relationship between palmitoylation genes mediated by immune cell phenotypes and oral cancer: A Mendelian randomized study.,2025,10.1097/md.0000000000046158,https://pubmed.ncbi.nlm.nih.gov/41465920/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,34897408,ZDHHC19 localizes to the cell membrane of spermatids and is involved in spermatogenesis†.,2022,10.1093/biolre/ioab224,https://pubmed.ncbi.nlm.nih.gov/34897408/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,35297315,Zinc finger Asp-His-His-Cys palmitoyl -acyltransferase 19 accelerates tumor progression through wnt/β-catenin pathway and is upregulated by miR-940 in osteosarcoma.,2022,10.1080/21655979.2022.2040827,https://pubmed.ncbi.nlm.nih.gov/35297315/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,37802024,S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy.,2023,10.1016/j.molcel.2023.09.004,https://pubmed.ncbi.nlm.nih.gov/37802024/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,39516835,Exploring multi-omics and clinical characteristics linked to accelerated biological aging in Asian women of reproductive age: insights from the S-PRESTO study.,2024,10.1186/s13073-024-01403-7,https://pubmed.ncbi.nlm.nih.gov/39516835/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,38124295,S-acylation regulates SQSTM1/p62-mediated selective autophagy.,2024,10.1080/15548627.2023.2297623,https://pubmed.ncbi.nlm.nih.gov/38124295/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,39543761,A genome-wide association study in Swedish colorectal cancer patients with gastric- and prostate cancer in relatives.,2024,10.1186/s13053-024-00299-z,https://pubmed.ncbi.nlm.nih.gov/39543761/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,38860590,The dynamic molecular characteristics of neutrophils are associated with disease progression in dengue patients.,2024,10.1002/jmv.29729,https://pubmed.ncbi.nlm.nih.gov/38860590/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,39480635,Transriptome Analysis of Peripheral Blood Monocytes in Chronic Obstructive Pulmonary Disease Patients.,2024,10.1134/s1607672924701199,https://pubmed.ncbi.nlm.nih.gov/39480635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,31462771,Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation.,2019,10.1038/s41586-019-1511-x,https://pubmed.ncbi.nlm.nih.gov/31462771/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,34707087,Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation.,2021,10.1038/s41389-021-00361-8,https://pubmed.ncbi.nlm.nih.gov/34707087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,30404808,Fatty Acid Synthase Promotes the Palmitoylation of Chikungunya Virus nsP1.,2019,10.1128/jvi.01747-18,https://pubmed.ncbi.nlm.nih.gov/30404808/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC19,ENSG00000163958,Unsafe,33364189,Bioinformatics Analysis of the Prognostic and Biological Significance of ZDHHC-Protein Acyltransferases in Kidney Renal Clear Cell Carcinoma.,2020,10.3389/fonc.2020.565414,https://pubmed.ncbi.nlm.nih.gov/33364189/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,42858533,Androgen receptor-regulated ZNF419 modulates ferroptosis sensitivity via the ZDHHC20-GPX4 pathway in prostate cancer.,2026,10.1016/j.redox.2026.104433,https://pubmed.ncbi.nlm.nih.gov/42858533/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,42142278,Transcriptomic Analysis and Multiple Machine Learning Approaches Identify ZDHHC20 and Its Highly Correlated Gene AK5 as Biomarkers in Multiple System Atrophy.,2026,10.1007/s12031-026-02541-w,https://pubmed.ncbi.nlm.nih.gov/42142278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,41882733,MEF2A activates the ZDHHC20/NF-κB pathway to inhibit doxorubicin sensitivity and promote the malignant progression of acute myeloid leukemia.,2026,10.1186/s13062-026-00762-y,https://pubmed.ncbi.nlm.nih.gov/41882733/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,42106497,Integration of transcriptome and DNA methylation reveals the mechanism of cilia-related genes in recurrent miscarriage.,2026,10.1038/s41598-026-52154-x,https://pubmed.ncbi.nlm.nih.gov/42106497/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,42011944,Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20-Mediated CMPK2 Palmitoylation.,2026,10.1002/advs.75209,https://pubmed.ncbi.nlm.nih.gov/42011944/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,41099891,An Investigation of the Causal Link Between Palmoylation Genes and Epilepsy Utilising Multi-omics Mendelian Randomisation Analysis and Validation Through Single-Cell Evidence.,2025,10.1007/s12031-025-02434-4,https://pubmed.ncbi.nlm.nih.gov/41099891/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,41826695,Palmitoylation-mediated regulation of KAT2A promotes lung metastasis in breast cancer.,2026,10.1038/s41556-026-01913-z,https://pubmed.ncbi.nlm.nih.gov/41826695/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,41586981,SREBP2-RAB11A-ZDHHC20 axis orchestrates FGFR3 palmitoylation and membrane retention to drive bladder cancer progression.,2026,10.1007/s13402-026-01163-z,https://pubmed.ncbi.nlm.nih.gov/41586981/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,41084588,DNA Methylation at cg18095732 Modulates ZDHHC20 Expression and Decreases Acne Vulgaris Risk.,2025,10.2147/ccid.s552840,https://pubmed.ncbi.nlm.nih.gov/41084588/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,40842128,Multi-Omics Mendelian Randomization Identifies a DNA Methylation-ZDHHC20-Immune Axis Associated With Schizophrenia Risk.,2025,10.1002/brb3.70722,https://pubmed.ncbi.nlm.nih.gov/40842128/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,41109928,ZDHHC20-mediated S-palmitoylation of KAP1/TRIM28 promotes DNA damage repair.,2025,10.1038/s41388-025-03604-9,https://pubmed.ncbi.nlm.nih.gov/41109928/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,41345585,Integrating single-cell RNA-Seq and machine learning to dissect a novel Palmitoylation-related prognostic signature of glioblastoma.,2025,10.1186/s12883-025-04551-4,https://pubmed.ncbi.nlm.nih.gov/41345585/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,39309302,ZDHHC20 Activates AKT Signaling Pathway to Promote Cell Proliferation in Hepatocellular Carcinoma.,2024,10.2147/jhc.s457682,https://pubmed.ncbi.nlm.nih.gov/39309302/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,39696259,ZDHHC20 mediated S-palmitoylation of fatty acid synthase (FASN) promotes hepatocarcinogenesis.,2024,10.1186/s12943-024-02195-5,https://pubmed.ncbi.nlm.nih.gov/39696259/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,42876031,Loss of Intestinal MSTN Promotes GLP-1 Secretion Through SGLT1 Palmitoylation.,2026,10.1002/advs.78302,https://pubmed.ncbi.nlm.nih.gov/42876031/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,38821916,ZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC mRNA to promote pancreatic cancer progression.,2024,10.1038/s41467-024-49105-3,https://pubmed.ncbi.nlm.nih.gov/38821916/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,42457410,zDHHC20b-mediated TRIF palmitoylation drives infection-induced necroptosis through the TRIF-RIPK3 axis in teleost monocytes/macrophages.,2026,10.24272/j.issn.2095-8137.2025.573,https://pubmed.ncbi.nlm.nih.gov/42457410/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,40898659,ZDHHC5 Mediates Immune Dysregulation Driving Generalized Anxiety Disorder Risk.,2025,10.1002/brb3.70818,https://pubmed.ncbi.nlm.nih.gov/40898659/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,39833225,Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis.,2025,10.1038/s41467-025-56344-5,https://pubmed.ncbi.nlm.nih.gov/39833225/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,38512906,Targeted degradation of zDHHC-PATs decreases substrate S-palmitoylation.,2024,10.1371/journal.pone.0299665,https://pubmed.ncbi.nlm.nih.gov/38512906/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,38467718,zDHHC20-driven S-palmitoylation of CD80 is required for its costimulatory function.,2024,10.1038/s41401-024-01248-1,https://pubmed.ncbi.nlm.nih.gov/38467718/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,38056161,Identification and validation of palmitoylation metabolism-related signature for liver hepatocellular carcinoma.,2024,10.1016/j.bbrc.2023.149325,https://pubmed.ncbi.nlm.nih.gov/38056161/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,34913437,S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse.,2021,10.7554/elife.72051,https://pubmed.ncbi.nlm.nih.gov/34913437/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,40605042,"Metabolic, transcriptomic, and proteomic adaptations in pancreatic ductal adenocarcinoma-patient derived xenograft models across serial passages.",2025,10.1186/s12967-025-06787-7,https://pubmed.ncbi.nlm.nih.gov/40605042/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,34589930,Oncogenic Fusions May Be Frequently Present at Resistance of EGFR Tyrosine Kinase Inhibitors in Patients With NSCLC: A Brief Report.,2020,10.1016/j.jtocrr.2020.100023,https://pubmed.ncbi.nlm.nih.gov/34589930/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZDHHC20,ENSG00000180776,Unsafe,30651383,Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.,2019,10.1212/wnl.0000000000006851,https://pubmed.ncbi.nlm.nih.gov/30651383/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFAND4,ENSG00000172671,Unsafe,42429318,Transcriptomics Reveals L-Carnitine to Enhance Semen Quality in Malabari Bucks via Nutrigenomic Regulation of Key Biological Processes Associated With Male Fertility.,2026,10.1111/rda.70266,https://pubmed.ncbi.nlm.nih.gov/42429318/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFAND4,ENSG00000172671,Unsafe,41120675,Integrating bulk and single-cell transcriptome to identify novel gene markers for germinal center B cells (GCB) subtype of diffuse large B-cell lymphoma.,2025,10.1007/s00277-025-06517-5,https://pubmed.ncbi.nlm.nih.gov/41120675/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFAND4,ENSG00000172671,Unsafe,36659877,Prospective study and validation of early warning marker discovery based on integrating multi-omics analysis in severe burn patients with sepsis.,2023,10.1093/burnst/tkac050,https://pubmed.ncbi.nlm.nih.gov/36659877/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFAND4,ENSG00000172671,Unsafe,30544692,Distinct Expression and Clinical Significance of Zinc Finger AN-1-Type Containing 4 in Oral Squamous Cell Carcinomas.,2018,10.3390/jcm7120534,https://pubmed.ncbi.nlm.nih.gov/30544692/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFAND4,ENSG00000172671,Unsafe,25682742,MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer.,2015,10.3892/or.2015.3798,https://pubmed.ncbi.nlm.nih.gov/25682742/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFAND4,ENSG00000172671,Unsafe,33545363,Identification of Novel Serological Autoantibodies in Takayasu Arteritis Patients Using HuProt Arrays.,2021,10.1074/mcp.ra120.002119,https://pubmed.ncbi.nlm.nih.gov/33545363/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFAND4,ENSG00000172671,Unsafe,29074611,Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma.,2018,10.1136/jclinpath-2017-204770,https://pubmed.ncbi.nlm.nih.gov/29074611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFAND4,ENSG00000172671,Unsafe,23590305,Functional genomic assessment of phosgene-induced acute lung injury in mice.,2013,10.1165/rcmb.2012-0337oc,https://pubmed.ncbi.nlm.nih.gov/23590305/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFAND4,ENSG00000172671,Unsafe,29936662,Progression Rate Associated Peripheral Blood Biomarkers of Parkinson's Disease.,2018,10.1007/s12031-018-1102-6,https://pubmed.ncbi.nlm.nih.gov/29936662/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP37,ENSG00000136866,Unsafe,41020869,Integration of eQTL and GEO Datasets to Identify Genes Associated with Breast Ductal Carcinoma In Situ.,2025,10.3390/cimb47090747,https://pubmed.ncbi.nlm.nih.gov/41020869/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP37,ENSG00000136866,Unsafe,39238829,Identification and Validation of Hub Genes and Construction of miRNA-Gene and Transcription Factor-Gene Networks in Adipogenesis of Mesenchymal Stem Cells.,2024,10.1155/2024/5789593,https://pubmed.ncbi.nlm.nih.gov/39238829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP37,ENSG00000136866,Unsafe,35674367,Cannabis significantly alters DNA methylation of the human ovarian follicle in a concentration-dependent manner.,2022,10.1093/molehr/gaac022,https://pubmed.ncbi.nlm.nih.gov/35674367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP37,ENSG00000136866,Unsafe,36360783,"Decoding Diabetes Biomarkers and Related Molecular Mechanisms by Using Machine Learning, Text Mining, and Gene Expression Analysis.",2022,10.3390/ijerph192113890,https://pubmed.ncbi.nlm.nih.gov/36360783/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP37,ENSG00000136866,Unsafe,36466608,Comprehensive analysis of dysregulated circular RNAs and construction of a ceRNA network involved in the pathology of Alzheimer's disease in a 5 × FAD mouse model.,2022,10.3389/fnagi.2022.1020699,https://pubmed.ncbi.nlm.nih.gov/36466608/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP37,ENSG00000136866,Unsafe,30641629,[Effect of Heixiaoyao Powder on Hippocampal Gene Expression Profile of Alzheimer's Disease Rats].,2016,,https://pubmed.ncbi.nlm.nih.gov/30641629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP37,ENSG00000136866,Unsafe,31231376,"Global miRNA, lncRNA, and mRNA Transcriptome Profiling of Endometrial Epithelial Cells Reveals Genes Related to Porcine Reproductive Failure Caused by Porcine Reproductive and Respiratory Syndrome Virus.",2019,10.3389/fimmu.2019.01221,https://pubmed.ncbi.nlm.nih.gov/31231376/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP37,ENSG00000136866,Unsafe,23844591,Five markers useful for the distinction of canine mammary malignancy.,2013,10.1186/1746-6148-9-138,https://pubmed.ncbi.nlm.nih.gov/23844591/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP37,ENSG00000136866,Unsafe,24766805,Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors.,2014,10.1016/j.cell.2014.04.006,https://pubmed.ncbi.nlm.nih.gov/24766805/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP37,ENSG00000136866,Unsafe,23778974,Outcome after surgery for primary hyperaldosteronism may depend on KCNJ5 tumor mutation status: a population-based study from Western Norway.,2013,10.1007/s00423-013-1093-2,https://pubmed.ncbi.nlm.nih.gov/23778974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP37,ENSG00000136866,Unsafe,15733658,Mouse ovary developmental RNA and protein markers from gene expression profiling.,2005,10.1016/j.ydbio.2004.11.029,https://pubmed.ncbi.nlm.nih.gov/15733658/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,42798489,Identification and experimental validation of prognostic genes associated with dietary restriction-related signatures in bladder cancer.,2026,10.3389/fimmu.2026.1891824,https://pubmed.ncbi.nlm.nih.gov/42798489/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,42622717,Establishment of a ZFP64::NCOA3 fusion-positive spindle cell/sclerosing rhabdomyosarcoma organoid model and evaluation of fusion-gene dependency.,2026,10.1007/s13577-026-01441-w,https://pubmed.ncbi.nlm.nih.gov/42622717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,40546958,The transcription factor ZFP64 promotes activity-dependent synapse elimination during postnatal cerebellar development.,2025,10.1016/j.isci.2025.112746,https://pubmed.ncbi.nlm.nih.gov/40546958/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,41075874,Clinicopathologic and Molecular Genetic Features of Spindle Cell Rhabdomyosarcoma Harboring ZFP64::NCOA2/3 Fusions: A Series of 14 Cases.,2025,10.1016/j.modpat.2025.100906,https://pubmed.ncbi.nlm.nih.gov/41075874/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,39628712,KDM1A-mediated ZFP64 demethylation activates CENPL to promote epithelial ovarian cancer progression.,2025,10.1007/s10616-024-00671-w,https://pubmed.ncbi.nlm.nih.gov/39628712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,40392482,Investigate the Effect of ZFP64 on mRNA Expression of HBG Based on Bioinformatics and Experimental Validation.,2025,10.1007/s12013-025-01776-5,https://pubmed.ncbi.nlm.nih.gov/40392482/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,39294751,ZFP64 drives glycolysis-mediated stem cell-like properties and tumorigenesis in breast cancer.,2024,10.1186/s13062-024-00533-7,https://pubmed.ncbi.nlm.nih.gov/39294751/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,40022222,Cancer-associated fibroblasts promote doxorubicin resistance in triple-negative breast cancer through enhancing ZFP64 histone lactylation to regulate ferroptosis.,2025,10.1186/s12967-025-06246-3,https://pubmed.ncbi.nlm.nih.gov/40022222/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,39706253,LncRNA FIRRE drives gastric cancer progression via ZFP64-mediated TUBB3 promoter activation.,2025,10.1016/j.canlet.2024.217398,https://pubmed.ncbi.nlm.nih.gov/39706253/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,37760477,ZFP64 Promotes Gallbladder Cancer Progression through Recruiting HDAC1 to Activate NOTCH1 Signaling Pathway.,2023,10.3390/cancers15184508,https://pubmed.ncbi.nlm.nih.gov/37760477/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,40503962,Soft tissue sarcoma with MN1 gene fusions: a report of three cases with aggressive clinical behavior.,2025,10.1002/path.6441,https://pubmed.ncbi.nlm.nih.gov/40503962/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,39147662,The Predictive Value of BUB1 in the Prognosis of Oral Squamous Cell Carcinoma.,2025,10.1016/j.identj.2024.07.012,https://pubmed.ncbi.nlm.nih.gov/39147662/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,34996504,Targeting ZFP64/GAL-1 axis promotes therapeutic effect of nab-paclitaxel and reverses immunosuppressive microenvironment in gastric cancer.,2022,10.1186/s13046-021-02224-x,https://pubmed.ncbi.nlm.nih.gov/34996504/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,35843097,ZFP64 transcriptionally activates PD-1 and CTLA-4 and plays an oncogenic role in esophageal cancer.,2022,10.1016/j.bbrc.2022.06.011,https://pubmed.ncbi.nlm.nih.gov/35843097/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,35521817,ZFP64::NCOA3 gene fusion defines a novel subset of spindle cell rhabdomyosarcoma.,2022,10.1002/gcc.23052,https://pubmed.ncbi.nlm.nih.gov/35521817/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,38721773,Neuroimaging and epigenetic analysis reveal novel epigenetic loci in major depressive disorder.,2024,10.1017/s0033291724000709,https://pubmed.ncbi.nlm.nih.gov/38721773/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,33054540,Function and mechanism exploration of zinc finger protein 64 in lung adenocarcinoma cell growth and metastasis.,2021,10.1080/10799893.2020.1825490,https://pubmed.ncbi.nlm.nih.gov/33054540/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,30503706,A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence.,2018,10.1016/j.ccell.2018.10.015,https://pubmed.ncbi.nlm.nih.gov/30503706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,37422156,Fusion-driven Spindle Cell Rhabdomyosarcomas of Bone and Soft Tissue: A Clinicopathologic and Molecular Genetic Study of 25 Cases.,2023,10.1016/j.modpat.2023.100271,https://pubmed.ncbi.nlm.nih.gov/37422156/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,23857586,Zinc finger protein 64 promotes Toll-like receptor-triggered proinflammatory and type I interferon production in macrophages by enhancing p65 subunit activation.,2013,10.1074/jbc.m113.473397,https://pubmed.ncbi.nlm.nih.gov/23857586/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,35219791,PKCα/ZFP64/CSF1 axis resets the tumor microenvironment and fuels anti-PD1 resistance in hepatocellular carcinoma.,2022,10.1016/j.jhep.2022.02.019,https://pubmed.ncbi.nlm.nih.gov/35219791/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP64,ENSG00000020256,Unsafe,26952006,Resminostat plus sorafenib as second-line therapy of advanced hepatocellular carcinoma - The SHELTER study.,2016,10.1016/j.jhep.2016.02.043,https://pubmed.ncbi.nlm.nih.gov/26952006/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP69,ENSG00000187815,Unsafe,42021739,Endothelial NOX1 Drives Obesity via Skeletal Muscle Mitochondrial Dysfunction.,2026,10.1161/circresaha.125.326768,https://pubmed.ncbi.nlm.nih.gov/42021739/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP69,ENSG00000187815,Unsafe,26232096,The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice.,2015,10.1007/s00125-015-3703-8,https://pubmed.ncbi.nlm.nih.gov/26232096/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP69,ENSG00000187815,Unsafe,35427894,HCG15 is a hypoxia-responsive lncRNA and facilitates hepatocellular carcinoma cell proliferation and invasion by enhancing ZNF641 transcription.,2022,10.1016/j.bbrc.2022.03.143,https://pubmed.ncbi.nlm.nih.gov/35427894/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP69,ENSG00000187815,Unsafe,19578398,"Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL.",2009,10.1371/journal.pgen.1000541,https://pubmed.ncbi.nlm.nih.gov/19578398/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP69,ENSG00000187815,Unsafe,24752583,The genetic basis of obesity-associated type 2 diabetes (diabesity) in polygenic mouse models.,2014,10.1007/s00335-014-9514-2,https://pubmed.ncbi.nlm.nih.gov/24752583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP69,ENSG00000187815,Unsafe,20865372,Role of zinc finger transcription factor zfp69 in body fat storage and diabetes susceptibility of mice.,2010,10.1007/978-3-642-14426-4_6,https://pubmed.ncbi.nlm.nih.gov/20865372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP69,ENSG00000187815,Unsafe,20865367,"The genetic basis of obesity and type 2 diabetes: lessons from the new zealand obese mouse, a polygenic model of the metabolic syndrome.",2010,10.1007/978-3-642-14426-4_1,https://pubmed.ncbi.nlm.nih.gov/20865367/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP69,ENSG00000187815,Unsafe,22471599,Mouse obesity network reconstruction with a variational Bayes algorithm to employ aggressive false positive control.,2012,10.1186/1471-2105-13-53,https://pubmed.ncbi.nlm.nih.gov/22471599/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP69,ENSG00000187815,Unsafe,22893401,Pathophysiology and genetics of obesity and diabetes in the New Zealand obese mouse: a model of the human metabolic syndrome.,2012,10.1007/978-1-62703-068-7_5,https://pubmed.ncbi.nlm.nih.gov/22893401/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFP69,ENSG00000187815,Unsafe,22010005,Systems genetics of susceptibility to obesity-induced diabetes in mice.,2012,10.1152/physiolgenomics.00003.2011,https://pubmed.ncbi.nlm.nih.gov/22010005/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFPL1,ENSG00000162300,Unsafe,41216870,ZFPL1 Promotes Colorectal Cancer Progression by Stabilizing ASS1 to Drive the Urea Cycle and M2 Macrophage-Mediated Metastatic Colonization.,2025,10.1002/advs.202505291,https://pubmed.ncbi.nlm.nih.gov/41216870/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFPL1,ENSG00000162300,Unsafe,41783436,AMACR and ZFPL1 serum biomarkers enhance precision in predicting postoperative prostate cancer outcomes.,2026,10.3389/fonc.2026.1625125,https://pubmed.ncbi.nlm.nih.gov/41783436/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFPL1,ENSG00000162300,Unsafe,41833068,Exosomal ZFPL1 Identifies Neuroendocrine and Stem Cell-Like Prostate Cancer Subtypes?,2026,10.1002/pros.70148,https://pubmed.ncbi.nlm.nih.gov/41833068/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFPL1,ENSG00000162300,Unsafe,41352204,"Serum ZFPL1 as a clinical biomarker for diagnosis, progression tracking, and treatment response in lung cancer.",2026,10.1016/j.ctarc.2025.101052,https://pubmed.ncbi.nlm.nih.gov/41352204/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFPL1,ENSG00000162300,Unsafe,41588542,Development and validation of gene expression-based signature for high-grade serous ovarian cancer.,2026,10.1186/s13048-026-01989-z,https://pubmed.ncbi.nlm.nih.gov/41588542/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFPL1,ENSG00000162300,Unsafe,36799165,Zinc finger protein‑like 1 is a novel neuroendocrine biomarker for prostate cancer.,2023,10.3892/ijo.2023.5486,https://pubmed.ncbi.nlm.nih.gov/36799165/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFPL1,ENSG00000162300,Unsafe,41806660,Proteomic insights into the effects of cryopreservation on sperm of endangered Eld's deer (Rucervus eldii).,2026,10.1016/j.repbio.2026.101200,https://pubmed.ncbi.nlm.nih.gov/41806660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFPL1,ENSG00000162300,Unsafe,30036656,RING domain of zinc finger protein like 1 is essential for cell proliferation in endometrial cancer cell line RL95-2.,2018,10.1016/j.gene.2018.07.053,https://pubmed.ncbi.nlm.nih.gov/30036656/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFPL1,ENSG00000162300,Unsafe,28447717,Knockdown of ZFPL1 results in increased autophagy and autophagy‑related cell death in NCI‑N87 and BGC‑823 human gastric carcinoma cell lines.,2017,10.3892/mmr.2017.6300,https://pubmed.ncbi.nlm.nih.gov/28447717/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFPL1,ENSG00000162300,Unsafe,27199454,Comprehensive database of human E3 ubiquitin ligases: application to aquaporin-2 regulation.,2016,10.1152/physiolgenomics.00031.2016,https://pubmed.ncbi.nlm.nih.gov/27199454/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFPL1,ENSG00000162300,Unsafe,18323775,"ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport.",2008,10.1038/emboj.2008.40,https://pubmed.ncbi.nlm.nih.gov/18323775/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFPL1,ENSG00000162300,Unsafe,9653652,"A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. The European Consortium on MEN 1.",1998,10.1006/geno.1998.5307,https://pubmed.ncbi.nlm.nih.gov/9653652/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,41323271,Transcription factor Zfx regulates tumor's evasion to T cell killing in immunotherapy.,2025,10.1016/j.isci.2025.113842,https://pubmed.ncbi.nlm.nih.gov/41323271/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,42167485,Single-cell multiomics gene regulatory landscape reveals impaired spermatogonial stem cells and macrophage-driven inflammaging during testicular aging.,2026,10.1016/j.jgg.2026.05.005,https://pubmed.ncbi.nlm.nih.gov/42167485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,41074764,De Novo Heterozygous ZFX Frameshift Variant in a Female With an X-Linked Neurodevelopmental Disorder.,2026,10.1002/ajmg.a.64280,https://pubmed.ncbi.nlm.nih.gov/41074764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,40934285,The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms.,2025,10.1371/journal.pbio.3003362,https://pubmed.ncbi.nlm.nih.gov/40934285/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,41512022,Systematic identification of single transcription factor perturbations that drive cellular and tissue rejuvenation.,2026,10.1073/pnas.2515183123,https://pubmed.ncbi.nlm.nih.gov/41512022/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,41055764,lncRNA TMEM147-AS1 promotes acute myeloid leukemia development by regulating miR-873-3p/ZFX axis.,2025,10.1007/s10735-025-10607-z,https://pubmed.ncbi.nlm.nih.gov/41055764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,40779536,Association of germline variants in the ZFX gene with primary hyperparathyroidism.,2025,10.1371/journal.pone.0329388,https://pubmed.ncbi.nlm.nih.gov/40779536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,40491779,IGFBP1 is One of 10 Metabolic Factors Predicting Recurrence Free Survival in Gastric Cancer and Promotes Cancer Progression via ZFX-IGFBP1 Axis.,2025,10.2147/ott.s499695,https://pubmed.ncbi.nlm.nih.gov/40491779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,39940742,Expression Patterns of Escape Genes in Turner Syndrome Fibroblasts and Induced Pluripotent Stem Cells.,2025,10.3390/ijms26030975,https://pubmed.ncbi.nlm.nih.gov/39940742/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,42145970,Integrative Bioinformatics Analyses Reveal X Chromosome Inactivation Escape Genes Dosage Dysregulation Is the Primary Contributor to Turner Syndrome.,2026,10.30498/ijb.2025.558422.4286,https://pubmed.ncbi.nlm.nih.gov/42145970/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,39048311,Comparing the roles of sex chromosome-encoded protein homologs in gene regulation.,2024,10.1101/gad.351890.124,https://pubmed.ncbi.nlm.nih.gov/39048311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,41934611,Transcriptional mechanisms of sex-biased gene expression and their connections to disease-associated variation.,2026,10.1093/hmg/ddag019,https://pubmed.ncbi.nlm.nih.gov/41934611/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,40684995,Pitavastatin overcomes multi-drug resistance in CRC and NSCLC by targeting the NRP1-ZFX axis.,2025,10.1016/j.bcp.2025.117183,https://pubmed.ncbi.nlm.nih.gov/40684995/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,40670382,Interpretable deep learning framework for understanding molecular changes in human brains with Alzheimer's disease: implications for microglia activation and sex differences.,2025,10.1038/s41514-025-00258-5,https://pubmed.ncbi.nlm.nih.gov/40670382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,39712568,Maintenance of stem cell self-renewal by sex chromosomal zinc-finger transcription factors.,2024,10.5662/wjm.v14.i4.97664,https://pubmed.ncbi.nlm.nih.gov/39712568/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,41961766,A Case of Disorder of Sex Development in Red Deer (&lt;italic&gt;Cervus elaphus&lt;/italic&gt;).,2026,10.1159/000551880,https://pubmed.ncbi.nlm.nih.gov/41961766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,37864206,A conserved ZFX/WNT3 axis modulates the growth and imatinib response of chronic myeloid leukemia stem/progenitor cells.,2023,10.1186/s11658-023-00496-z,https://pubmed.ncbi.nlm.nih.gov/37864206/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,39711969,Silencing of LINC01278 promotes sensitivity of non-small cell lung cancer cells to osimertinib by targeting miR-324-3p/ZFX axis.,2025,10.1007/s10616-024-00673-8,https://pubmed.ncbi.nlm.nih.gov/39711969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,38726870,Reduction of ZFX levels decreases histone H4 acetylation and increases Pol2 pausing at target promoters.,2024,10.1093/nar/gkae372,https://pubmed.ncbi.nlm.nih.gov/38726870/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,38325380,Variants in ZFX are associated with an X-linked neurodevelopmental disorder with recurrent facial gestalt.,2024,10.1016/j.ajhg.2024.01.007,https://pubmed.ncbi.nlm.nih.gov/38325380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,39111319,Stable and robust Xi and Y transcriptomes drive cell-type-specific autosomal and Xa responses in vivo and in vitro in four human cell types.,2024,10.1016/j.xgen.2024.100628,https://pubmed.ncbi.nlm.nih.gov/39111319/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,34324278,Circ_0000520 contributes to triple-negative breast cancer progression through mediating the miR-1296/ZFX axis.,2021,10.1111/1759-7714.14085,https://pubmed.ncbi.nlm.nih.gov/34324278/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,38167612,Distinct patterns of proteostasis network gene expression are associated with different prognoses in melanoma patients.,2024,10.1038/s41598-023-50640-0,https://pubmed.ncbi.nlm.nih.gov/38167612/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,33633466,Circ_0020123 Increases ZFX Expression to Facilitate Non-Small Cell Lung Cancer Progression by Sponging miR-142-3p.,2021,10.2147/cmar.s295595,https://pubmed.ncbi.nlm.nih.gov/33633466/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,30022979,The Transcription Factor Zfx Regulates Peripheral T Cell Self-Renewal and Proliferation.,2018,10.3389/fimmu.2018.01482,https://pubmed.ncbi.nlm.nih.gov/30022979/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,31310241,CCAT1 promotes triple-negative breast cancer progression by suppressing miR-218/ZFX signaling.,2019,10.18632/aging.102080,https://pubmed.ncbi.nlm.nih.gov/31310241/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,27797721,ZFX modulates the growth of human leukemic cells via B4GALT1.,2016,10.1093/abbs/gmw109,https://pubmed.ncbi.nlm.nih.gov/27797721/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,32257743,Methyl-indole inhibits pancreatic cancer cell viability by down-regulating ZFX expression.,2020,10.1007/s13205-020-02179-4,https://pubmed.ncbi.nlm.nih.gov/32257743/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,36611251,Genomic Profiling Reveals the Variant Landscape of Sporadic Parathyroid Adenomas in Chinese Population.,2023,10.1210/clinem/dgad002,https://pubmed.ncbi.nlm.nih.gov/36611251/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,35619722,A Decentralized Kidney Transplant Biopsy Classifier for Transplant Rejection Developed Using Genes of the Banff-Human Organ Transplant Panel.,2022,10.3389/fimmu.2022.841519,https://pubmed.ncbi.nlm.nih.gov/35619722/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,38389573,Mitochondrial-related hub genes in dermatomyositis: muscle and skin datasets-based identification and in vivo validation.,2024,10.3389/fgene.2024.1325035,https://pubmed.ncbi.nlm.nih.gov/38389573/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,34697318,Bone marrow derived stromal cells from myelodysplastic syndromes are altered but not clonally mutated in vivo.,2021,10.1038/s41467-021-26424-3,https://pubmed.ncbi.nlm.nih.gov/34697318/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,24485662,ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia.,2014,10.1016/j.celrep.2014.01.007,https://pubmed.ncbi.nlm.nih.gov/24485662/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,24831540,The zinc finger transcription factor ZFX is required for maintaining the tumorigenic potential of glioblastoma stem cells.,2014,10.1002/stem.1730,https://pubmed.ncbi.nlm.nih.gov/24831540/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,25164012,Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway.,2014,10.1158/0008-5472.can-14-0834,https://pubmed.ncbi.nlm.nih.gov/25164012/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFX,ENSG00000005889,Unsafe,25617627,Baicalein inhibits progression of gallbladder cancer cells by downregulating ZFX.,2015,10.1371/journal.pone.0114851,https://pubmed.ncbi.nlm.nih.gov/25617627/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,41420208,CRISPR/Cas9-mediated knock-in of the murine Y chromosomal genes Zfy1 and Zfy2.,2025,10.1186/s12864-025-12462-4,https://pubmed.ncbi.nlm.nih.gov/41420208/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,41896624,Zinc finger protein Y - linked as a potential biomarker for autoimmune hepatitis and multiple sclerosis which overlap with immune infiltration.,2026,10.1038/s41598-026-43283-4,https://pubmed.ncbi.nlm.nih.gov/41896624/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,40866672,Large-scale transcriptomic analyses reveal downstream target genes of ZFY1 and ZFY2 transcription factors in male germ cells.,2026,10.1038/s41418-025-01569-6,https://pubmed.ncbi.nlm.nih.gov/40866672/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,42821372,Statement of Retraction: Long non-coding RNA ZFY-AS1 represses periodontitis tissue inflammation and oxidative damage via modulating microRNA-129-5p/DEAD-Box helicase 3 X-linked axis.,2026,10.1080/21655979.2026.2728869,https://pubmed.ncbi.nlm.nih.gov/42821372/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,41961766,A Case of Disorder of Sex Development in Red Deer (&lt;italic&gt;Cervus elaphus&lt;/italic&gt;).,2026,10.1159/000551880,https://pubmed.ncbi.nlm.nih.gov/41961766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,37354519,Return of the forgotten hero: the role of Y chromosome-encoded Zfy in male reproduction.,2023,10.1093/molehr/gaad025,https://pubmed.ncbi.nlm.nih.gov/37354519/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,39048311,Comparing the roles of sex chromosome-encoded protein homologs in gene regulation.,2024,10.1101/gad.351890.124,https://pubmed.ncbi.nlm.nih.gov/39048311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,40670382,Interpretable deep learning framework for understanding molecular changes in human brains with Alzheimer's disease: implications for microglia activation and sex differences.,2025,10.1038/s41514-025-00258-5,https://pubmed.ncbi.nlm.nih.gov/40670382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,40419046,Protein interaction network drive more group integrated analytic larynx hub protein markers: LYVE1/FBLN5/INMT/DCN/ZFY/RSPO3 protein macromolecule collaborative diagnosis of a new era.,2025,10.1016/j.ijbiomac.2025.144586,https://pubmed.ncbi.nlm.nih.gov/40419046/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,38971779,"Unusual sex chromosomal DSD in a domestic Shorthair cat with a 37,X/38,XY mosaic karyotype.",2024,10.1186/s12917-024-04164-y,https://pubmed.ncbi.nlm.nih.gov/38971779/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,35293998,"Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility.",2022,10.1093/biolre/ioac057,https://pubmed.ncbi.nlm.nih.gov/35293998/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,39712568,Maintenance of stem cell self-renewal by sex chromosomal zinc-finger transcription factors.,2024,10.5662/wjm.v14.i4.97664,https://pubmed.ncbi.nlm.nih.gov/39712568/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,42650136,Cytogenetic Characterization of the Yak (&lt;i&gt;Bos grunniens&lt;/i&gt;) Prometaphase Chromosomes and Comparison with Cattle (&lt;i&gt;Bos taurus&lt;/i&gt;).,2026,10.3390/genes17080943,https://pubmed.ncbi.nlm.nih.gov/42650136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,39090720,Unveiling potential: urinary exosomal mRNAs as non-invasive biomarkers for early prostate cancer diagnosis.,2024,10.1186/s12894-024-01540-6,https://pubmed.ncbi.nlm.nih.gov/39090720/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,41074104,Saliva as a potential and non-invasive approach to identify upregulated genes associated with comorbidities of T1DM: a brief report.,2025,10.1186/s40001-025-03105-1,https://pubmed.ncbi.nlm.nih.gov/41074104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,42386666,"[Identification of a pregnant woman with tetragametic chimera of 46,XY/46,XX karyotype presenting as mixed agglutination during ABO blood group forward typing].",2026,10.3760/cma.j.cn511374-20251110-00652,https://pubmed.ncbi.nlm.nih.gov/42386666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,36359056,XX/XY Chimerism in Internal Genitalia of a Virilized Heifer.,2022,10.3390/ani12212932,https://pubmed.ncbi.nlm.nih.gov/36359056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,38190107,The human Y and inactive X chromosomes similarly modulate autosomal gene expression.,2024,10.1016/j.xgen.2023.100462,https://pubmed.ncbi.nlm.nih.gov/38190107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,36441391,"Non-mosaic X monosomy (77,X) in a female dog with signs of virilization.",2023,10.1007/s13353-022-00739-3,https://pubmed.ncbi.nlm.nih.gov/36441391/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,39111319,Stable and robust Xi and Y transcriptomes drive cell-type-specific autosomal and Xa responses in vivo and in vitro in four human cell types.,2024,10.1016/j.xgen.2024.100628,https://pubmed.ncbi.nlm.nih.gov/39111319/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,29505743,"A genetic method for sex determination in Ovis spp. by interruption of the zinc finger protein, Y-linked (ZFY) gene on the Y chromosome.",2018,10.1071/rd17339,https://pubmed.ncbi.nlm.nih.gov/29505743/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,33488287,Male advantage observed for in vitro fertilization mouse embryos exhibiting early cleavage.,2021,10.1002/rmb2.12355,https://pubmed.ncbi.nlm.nih.gov/33488287/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,34954105,A new insight into sex-specific non-coding RNAs and networks in response to SARS-CoV-2.,2022,10.1016/j.meegid.2021.105195,https://pubmed.ncbi.nlm.nih.gov/34954105/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,31817322,Sex Determination Using RNA-Sequencing Analyses in Early Prenatal Pig Development.,2019,10.3390/genes10121010,https://pubmed.ncbi.nlm.nih.gov/31817322/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,20457032,Forensic DNA against wildlife poaching: identification of a serial wolf killing in Italy.,2010,10.1016/j.fsigen.2009.10.012,https://pubmed.ncbi.nlm.nih.gov/20457032/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,15613541,Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission.,2005,10.1182/blood-2004-09-3660,https://pubmed.ncbi.nlm.nih.gov/15613541/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,17174306,hnRNP-U enhances the expression of specific genes by stabilizing mRNA.,2007,10.1016/j.febslet.2006.11.062,https://pubmed.ncbi.nlm.nih.gov/17174306/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,8401500,Preimplantation prevention of X-linked disease: reliable and rapid sex determination of single human cells by restriction analysis of simultaneously amplified ZFX and ZFY sequences.,1993,10.1093/hmg/2.8.1187,https://pubmed.ncbi.nlm.nih.gov/8401500/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,9143681,"The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning.",1997,10.1146/annurev.immunol.15.1.39,https://pubmed.ncbi.nlm.nih.gov/9143681/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZFY,ENSG00000067646,Unsafe,7586641,"Clinical traits and molecular findings in 46,XX males.",1995,10.1111/j.1399-0004.1995.tb04050.x,https://pubmed.ncbi.nlm.nih.gov/7586641/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,41694394,ZIC2 drives colorectal cancer progression by regulating QPRT-mediated cell migration.,2026,10.3389/fimmu.2026.1722707,https://pubmed.ncbi.nlm.nih.gov/41694394/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,42033229,Dual role of ZIC2 during neural induction: from priming transcription factor to enhancer activator.,2026,10.1093/nar/gkag374,https://pubmed.ncbi.nlm.nih.gov/42033229/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,42321866,Gut microbiota-associated leucine elevation promotes cold-induced atherosclerotic plaque formation and instability.,2026,10.1186/s12967-026-08492-5,https://pubmed.ncbi.nlm.nih.gov/42321866/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,41856987,ZIC2 affects oral squamous cell carcinoma stemness by regulating glycerophosphocholine metabolism via LYPLA2.,2026,10.1038/s41419-026-08483-w,https://pubmed.ncbi.nlm.nih.gov/41856987/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,42411605,Arrayed single-gene perturbations identify drivers of human anterior neural tube closure.,2026,10.7554/elife.108224,https://pubmed.ncbi.nlm.nih.gov/42411605/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,42045587,"Multi-omics integration reveals pan-cancer roles of ZIC family genes in prognosis, immune microenvironment remodeling, and therapeutic vulnerability.",2026,10.1007/s12672-026-05100-2,https://pubmed.ncbi.nlm.nih.gov/42045587/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,40768377,METTL3-mediated m6A modification of ZIC2 promotes osteosarcoma development.,2025,10.1080/03008207.2025.2540041,https://pubmed.ncbi.nlm.nih.gov/40768377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,39888066,Carboxyl Terminal Modulator Protein Induces Cell Senescence and Is Upregulated With Aging by Zic2 in Rats.,2025,10.1002/jcp.70007,https://pubmed.ncbi.nlm.nih.gov/39888066/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,42360372,Zinc finger protein-associated gene signature serves as a potential predictor for prognosis and therapeutic response in lung adenocarcinoma.,2026,10.1007/s00726-026-03528-y,https://pubmed.ncbi.nlm.nih.gov/42360372/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,42051488,Commentary: ZIC2 drives colorectal cancer progression by regulating QPRT-mediated cell migration.,2026,10.3389/fimmu.2026.1823749,https://pubmed.ncbi.nlm.nih.gov/42051488/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,40520016,Mechanistic role of metal-responsive transcription factor-1 (MTF1) in cadmium-induced prostate carcinogenesis.,2025,10.7150/ijbs.110174,https://pubmed.ncbi.nlm.nih.gov/40520016/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,42634678,Middle Interhemispheric Variant of Holoprosencephaly With Septo-Optic Dysplasia: A Rare Association.,2026,10.7759/cureus.113295,https://pubmed.ncbi.nlm.nih.gov/42634678/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,39353531,Gastrodin attenuates high fructose-induced sweet taste preference decrease by inhibiting hippocampal neural stem cell ferroptosis.,2025,10.1016/j.jare.2024.09.025,https://pubmed.ncbi.nlm.nih.gov/39353531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,41607538,A novel prognostic model for Hedgehog signaling pathway-related genes predicts the prognosis of hepatocellular carcinoma.,2025,10.3389/fonc.2025.1674924,https://pubmed.ncbi.nlm.nih.gov/41607538/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,40895068,Exploration of prognostic genes associated with lymphangiogenesis in breast cancer based on transcriptomics and experimental verification.,2025,10.7717/peerj.19890,https://pubmed.ncbi.nlm.nih.gov/40895068/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,40401000,Decoding the pro-invasive role of SAA2 in renal cell carcinoma: an exploratory study and experimental validation.,2025,10.62347/tkdl1531,https://pubmed.ncbi.nlm.nih.gov/40401000/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,38977039,Effect of ZIC2 on immune infiltration and ceRNA axis regulation in lung adenocarcinoma via bioinformatics and experimental studies.,2024,10.1016/j.mcp.2024.101971,https://pubmed.ncbi.nlm.nih.gov/38977039/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,38304730,Identification of ZIC2 as a Potential Biomarker Linked with the Clinical Progression and Immune Infiltration of Oral Cancer: A Multicenter Study.,2024,10.1155/2024/3256694,https://pubmed.ncbi.nlm.nih.gov/38304730/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,40033291,Identification of a novel non-coding deletion in Allan-Herndon-Dudley syndrome by long-read HiFi genome sequencing.,2025,10.1186/s12920-024-02058-4,https://pubmed.ncbi.nlm.nih.gov/40033291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,39358345,ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency.,2024,10.1038/s41467-024-52431-1,https://pubmed.ncbi.nlm.nih.gov/39358345/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,41603185,Prediction of Clinical Outcomes and Immunotherapy Response in Breast Cancer Based on T Cell-Mediated Tumor Killing-Related Traits.,2026,10.2174/0118715303429021251024053150,https://pubmed.ncbi.nlm.nih.gov/41603185/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,37399175,Identification of Immune Subtypes and Candidate mRNA Vaccine Antigens in Small Cell Lung Cancer.,2023,10.1093/oncolo/oyad193,https://pubmed.ncbi.nlm.nih.gov/37399175/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,39816565,Construction of a prognostic survival model with tumor immune-related genes for breast cancer.,2024,10.21037/tcr-24-2137,https://pubmed.ncbi.nlm.nih.gov/39816565/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,42049996,Multi-modal circulating cell-free DNA profiling to predict response to docetaxel in metastatic castration-resistant prostate cancer.,2026,10.1038/s41698-026-01454-6,https://pubmed.ncbi.nlm.nih.gov/42049996/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,37479694,ZIC2 induces pro-tumor macrophage polarization in nasopharyngeal carcinoma by activating the JUNB/MCSF axis.,2023,10.1038/s41419-023-05983-x,https://pubmed.ncbi.nlm.nih.gov/37479694/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,38410689,Identification and Analysis of ZIC-Related Genes in Cerebellum of Autism Spectrum Disorders.,2024,10.2147/ndt.s444138,https://pubmed.ncbi.nlm.nih.gov/38410689/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,37957420,Prognostic clinical phenotypes associated with tumor stemness in the immune microenvironment of T-cell exhaustion for hepatocellular carcinoma.,2023,10.1007/s12672-023-00819-8,https://pubmed.ncbi.nlm.nih.gov/37957420/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,37496990,FOXM1-regulated ZIC2 promotes the malignant phenotype of renal clear cell carcinoma by activating UBE2C/mTOR signaling pathway.,2023,10.7150/ijbs.84067,https://pubmed.ncbi.nlm.nih.gov/37496990/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,37596527,A novel super-enhancer-related gene signature predicts prognosis and immune microenvironment for breast cancer.,2023,10.1186/s12885-023-11241-2,https://pubmed.ncbi.nlm.nih.gov/37596527/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,33439969,"Correlation of zinc finger protein 2, a prognostic biomarker, with immune infiltrates in liver cancer.",2021,10.1042/bsr20203115,https://pubmed.ncbi.nlm.nih.gov/33439969/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC2,ENSG00000043355,Unsafe,38488671,RETRACTED: Exploring the tumor microenvironment: Chemokine-related genes and immunotherapy/chemotherapy response in clear-cell renal cell carcinoma.,2025,10.1002/tox.24190,https://pubmed.ncbi.nlm.nih.gov/38488671/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,42698844,Characterization of ZIC5 expression in esophageal squamous cell carcinoma and its association with patient survival.,2026,10.3892/ol.2026.15834,https://pubmed.ncbi.nlm.nih.gov/42698844/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,41266464,"ZIC5, a survival biomarker, facilitates tumor progression and stemness in colon cancer via the activation of the Wnt signaling pathway.",2025,10.1038/s41598-025-24809-8,https://pubmed.ncbi.nlm.nih.gov/41266464/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,42503245,CLCF1-ZIC5-CNTFR feedback loop drives cisplatin resistance in cervical squamous cell carcinoma.,2026,10.1016/j.neo.2026.101342,https://pubmed.ncbi.nlm.nih.gov/42503245/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,42537374,Research note: Zic5 alters digit morphology during avian limb development.,2026,10.1016/j.psj.2026.107420,https://pubmed.ncbi.nlm.nih.gov/42537374/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,42041682,A Pan-Cancer Transcriptomic Signature for Conserved Molecular Programs Underlying Premalignant-Malignant Progression Across Common Carcinomas.,2026,10.3390/dj14040228,https://pubmed.ncbi.nlm.nih.gov/42041682/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,42045587,"Multi-omics integration reveals pan-cancer roles of ZIC family genes in prognosis, immune microenvironment remodeling, and therapeutic vulnerability.",2026,10.1007/s12672-026-05100-2,https://pubmed.ncbi.nlm.nih.gov/42045587/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,40366858,Silencing ZIC5 suppresses glycolysis and promotes disulfidptosis in lung adenocarcinoma cells.,2025,10.1080/15384047.2025.2501780,https://pubmed.ncbi.nlm.nih.gov/40366858/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,40318167,Zic family member 5 promotes RIO kinase 3 expression to enhance pancreatic cancer survival.,2025,10.1111/febs.70125,https://pubmed.ncbi.nlm.nih.gov/40318167/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,40344305,LncRNA OIP5-AS1 Modulates the Biological Behaviour of Lung Cancer Cells by Regulating the hsa-miR-29b-3p/ZIC5 Axis.,2025,10.1111/jcmm.70596,https://pubmed.ncbi.nlm.nih.gov/40344305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,41751625,Regulatory Potential of piRNAs Targeting &lt;i&gt;Klotho&lt;/i&gt; and Other Genes.,2026,10.3390/genes17020241,https://pubmed.ncbi.nlm.nih.gov/41751625/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,39969322,Refining of cancer-specific genes in microsatellite-unstable colon and endometrial cancers using modified partial least square discriminant analysis.,2024,10.1097/md.0000000000041134,https://pubmed.ncbi.nlm.nih.gov/39969322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,38747731,Research progress of ZIC5 for tumor metastasis.,2024,10.1042/bst20231263,https://pubmed.ncbi.nlm.nih.gov/38747731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,35669984,Zic family member 5 promotes survival in human pancreatic cancer and cholangiocarcinoma cells.,2022,10.1016/j.bbrep.2022.101289,https://pubmed.ncbi.nlm.nih.gov/35669984/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,35837163,ZIC5 promotes human hepatocellular carcinoma cell proliferation through upregulating COL1A1.,2022,10.21037/jgo-22-335,https://pubmed.ncbi.nlm.nih.gov/35837163/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,36127329,AR-regulated ZIC5 contributes to the aggressiveness of prostate cancer.,2022,10.1038/s41420-022-01181-4,https://pubmed.ncbi.nlm.nih.gov/36127329/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,36495760,ZIC5 promotes aggressiveness and cancer stemness in cervical squamous cell carcinoma.,2023,10.1016/j.prp.2022.154268,https://pubmed.ncbi.nlm.nih.gov/36495760/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,36282887,Patulin and LL-Z1640-2 induce apoptosis of cancer cells by decreasing endogenous protein levels of Zic family member 5.,2022,10.1111/jcmm.17598,https://pubmed.ncbi.nlm.nih.gov/36282887/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,35927800,LINC01116 Regulates the Proliferation and Apoptosis of Nucleus Pulposus Cells through miR-9-5p-mediated ZIC5 and the Wnt Pathway and Affects the Progression of Intervertebral Disc Degeneration.,2023,10.2174/1574888x17666220804105305,https://pubmed.ncbi.nlm.nih.gov/35927800/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,37228492,"Establishment, characterization, and drug screening of low-passage patient individual non-small cell lung cancer in vitro models including the rare pleomorphic subentity.",2023,10.3389/fonc.2023.1089681,https://pubmed.ncbi.nlm.nih.gov/37228492/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,36752150,MicroRNA-101-3p inhibits nasopharyngeal carcinoma cell proliferation and cisplatin resistance through ZIC5 down-regulation by targeting SOX2.,2023,10.1515/hsz-2022-0329,https://pubmed.ncbi.nlm.nih.gov/36752150/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,35593226,Identifying tumor antigens and immuno-subtyping in colon adenocarcinoma to facilitate the development of mRNA vaccine.,2022,10.1002/cam4.4846,https://pubmed.ncbi.nlm.nih.gov/35593226/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,33747280,Zinc finger of the cerebellum 5 promotes colorectal cancer cell proliferation and cell cycle progression through enhanced CDK1/CDC25c signaling.,2021,10.5114/aoms.2019.89677,https://pubmed.ncbi.nlm.nih.gov/33747280/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,33771929,"WNT-responsive SUMOylation of ZIC5 promotes murine neural crest cell development, having multiple effects on transcription.",2021,10.1242/jcs.256792,https://pubmed.ncbi.nlm.nih.gov/33771929/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,35733175,Exploring the potential mechanism of emetine against coronavirus disease 2019 combined with lung adenocarcinoma: bioinformatics and molecular simulation analyses.,2022,10.1186/s12885-022-09763-2,https://pubmed.ncbi.nlm.nih.gov/35733175/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,29472839,Ketamine Modulates Zic5 Expression via the Notch Signaling Pathway in Neural Crest Induction.,2018,10.3389/fnmol.2018.00009,https://pubmed.ncbi.nlm.nih.gov/29472839/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,34281170,In Silico Target Prediction of Overexpressed microRNAs from LPS-Challenged Zebrafish (Danio rerio) Treated with the Novel Anti-Inflammatory Peptide TnP.,2021,10.3390/ijms22137117,https://pubmed.ncbi.nlm.nih.gov/34281170/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,29385312,Toxicity implications for early life stage Japanese medaka (Oryzias latipes) exposed to oxyfluorfen.,2018,10.1002/tox.22541,https://pubmed.ncbi.nlm.nih.gov/29385312/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,24648413,Retinoic acid suppresses the canonical Wnt signaling pathway in embryonic stem cells and activates the noncanonical Wnt signaling pathway.,2014,10.1002/stem.1706,https://pubmed.ncbi.nlm.nih.gov/24648413/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,25206669,Differentiation of neuron-like cells from mouse parthenogenetic embryonic stem cells.,2013,10.3969/j.issn.1673-5374.2013.04.001,https://pubmed.ncbi.nlm.nih.gov/25206669/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZIC5,ENSG00000139800,Unsafe,17913529,Ethanol teratogenesis in Japanese medaka: effects at the cellular level.,2008,10.1016/j.cbpb.2007.09.008,https://pubmed.ncbi.nlm.nih.gov/17913529/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN2,ENSG00000155592,Unsafe,42228288,A novel model based on ferroptosis-related lncRNAs for predicting prognosis and adjuvant therapy response in colon adenocarcinoma.,2026,10.1007/s12672-026-05306-4,https://pubmed.ncbi.nlm.nih.gov/42228288/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN2,ENSG00000155592,Unsafe,39188141,Bioinformatics analysis and identification of cuproptosis-related long non-coding RNAs in colorectal cancer.,2024,10.1177/03000605241274563,https://pubmed.ncbi.nlm.nih.gov/39188141/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN2,ENSG00000155592,Unsafe,37612868,Machine Learning-derived Multi-omics Prognostic Signature of Pyroptosis-related lncRNA with Regard to ZKSCAN2-DT and Tumor Immune Infiltration in Colorectal Cancer.,2024,10.2174/1386207326666230823104952,https://pubmed.ncbi.nlm.nih.gov/37612868/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN2,ENSG00000155592,Unsafe,40226108,Identification of a glycolysis-associated lncRNA signature to predict survival of patients with colorectal cancer.,2025,10.62347/rvly4737,https://pubmed.ncbi.nlm.nih.gov/40226108/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN2,ENSG00000155592,Unsafe,37072493,A cuproptosis-related lncRNA signature to predict prognosis and immune microenvironment of colon adenocarcinoma.,2023,10.1038/s41598-023-33557-6,https://pubmed.ncbi.nlm.nih.gov/37072493/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,39519085,The Biological Roles of ZKSCAN3 (ZNF306) in the Hallmarks of Cancer: From Mechanisms to Therapeutics.,2024,10.3390/ijms252111532,https://pubmed.ncbi.nlm.nih.gov/39519085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,42866322,ZKSCAN3 mitigates lipopolysaccharide-induced acute lung injury by restraining excessive autophagy via activation of the mTOR pathway.,2026,10.21037/jtd-2026-1611,https://pubmed.ncbi.nlm.nih.gov/42866322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,40723888,Research Progress on the Functional Regulation Mechanisms of ZKSCAN3.,2025,10.3390/biom15071016,https://pubmed.ncbi.nlm.nih.gov/40723888/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,41037798,Targeted genome editing of ZKSCAN3 mitigates the neurotoxicity caused by mutant HTT (huntingtin) in a Huntington disease animal model and three-dimensional cell culture of Huntington disease.,2025,10.1080/15548627.2025.2569965,https://pubmed.ncbi.nlm.nih.gov/41037798/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,41393507,ZKSCAN3 promotes ovarian cancer cell proliferation by increasing HSPB1 expression.,2025,10.3389/fmolb.2025.1623062,https://pubmed.ncbi.nlm.nih.gov/41393507/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,42877618,Identification of candidate selenium-associated transcriptomic biomarkers in chronic obstructive pulmonary disease: an integrated bioinformatics and expression validation study.,2026,10.3389/fmed.2026.1909444,https://pubmed.ncbi.nlm.nih.gov/42877618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,40083599,ZKSCAN3 affects the autophagy‑lysosome pathway through TFEB in Parkinson's disease.,2025,10.3892/br.2025.1952,https://pubmed.ncbi.nlm.nih.gov/40083599/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,41329560,Cycloastragenol Ameliorates Psoriasis by Promoting Keratinocyte Autophagy via Modulating Subcellular Localization of ZKSCAN3.,2025,10.1111/cbdd.70210,https://pubmed.ncbi.nlm.nih.gov/41329560/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,38671550,"Expression of ZKSCAN3 protein suppresses proliferation, migration, and invasion of pancreatic cancer through autophagy.",2024,10.1111/cas.16173,https://pubmed.ncbi.nlm.nih.gov/38671550/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,41436647,Unveiling novel potential drug targets for lung cancer through Mendelian randomization analysis.,2025,10.1038/s41598-025-33574-7,https://pubmed.ncbi.nlm.nih.gov/41436647/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,39814340,Neuroprotective effects of chitinase-1 and calcitonin gene-related peptide on Alzheimer's disease by promoting lysosomal function.,2025,10.1177/13872877241307257,https://pubmed.ncbi.nlm.nih.gov/39814340/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,38617741,ALKBH5 suppresses autophagic flux via N6-methyladenosine demethylation of ZKSCAN3 mRNA in acute pancreatitis.,2024,10.3748/wjg.v30.i12.1764,https://pubmed.ncbi.nlm.nih.gov/38617741/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,37175493,"Effect of Lacking ZKSCAN3 on Autophagy, Lysosomal Biogenesis and Senescence.",2023,10.3390/ijms24097786,https://pubmed.ncbi.nlm.nih.gov/37175493/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,39844245,N&lt;sup&gt;ε&lt;/sup&gt;-carboxyethyl-lysin influences atherosclerotic plaque stability through ZKSCAN3 acetylation-regulated macrophage autophagy via the RAGE/LKB1/AMPK1/SIRT1 pathway.,2025,10.1186/s12933-025-02586-y,https://pubmed.ncbi.nlm.nih.gov/39844245/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,38781857,The demethylase ALKBH5 mediates ZKSCAN3 expression through the m6A modification to activate VEGFA transcription and thus participates in MNNG-induced gastric cancer progression.,2024,10.1016/j.jhazmat.2024.134690,https://pubmed.ncbi.nlm.nih.gov/38781857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,38797268,Targeting ONECUT2 inhibits tumor angiogenesis via down-regulating ZKSCAN3/VEGFA.,2024,10.1016/j.bcp.2024.116315,https://pubmed.ncbi.nlm.nih.gov/38797268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,37144628,Cardiomyocyte ZKSCAN3 regulates remodeling following pressure-overload.,2023,10.14814/phy2.15686,https://pubmed.ncbi.nlm.nih.gov/37144628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,41877008,DcSE: an improved densenet with enhanced attention fusion for super-enhancer prediction.,2026,10.1186/s12864-026-12768-x,https://pubmed.ncbi.nlm.nih.gov/41877008/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,41733899,Shared Genetic Basis and Causality Between Epilepsy and Psychiatric Disorders: Evidence From a Comprehensive Genetic Analysis.,2026,10.1002/brb3.71267,https://pubmed.ncbi.nlm.nih.gov/41733899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,36986600,Transcriptional Regulation of Liver-Type OATP1B3 (Lt-OATP1B3) and Cancer-Type OATP1B3 (Ct-OATP1B3) Studied in Hepatocyte-Derived and Colon Cancer-Derived Cell Lines.,2023,10.3390/pharmaceutics15030738,https://pubmed.ncbi.nlm.nih.gov/36986600/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,36012568,Role of the WNT/β-catenin/ZKSCAN3 Pathway in Regulating Chromosomal Instability in Colon Cancer Cell lines and Tissues.,2022,10.3390/ijms23169302,https://pubmed.ncbi.nlm.nih.gov/36012568/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,34654797,CHD1L augments autophagy-mediated migration of hepatocellular carcinoma through targeting ZKSCAN3.,2021,10.1038/s41419-021-04254-x,https://pubmed.ncbi.nlm.nih.gov/34654797/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,32178401,Cold Atmospheric Plasma and Silymarin Nanoemulsion Activate Autophagy in Human Melanoma Cells.,2020,10.3390/ijms21061939,https://pubmed.ncbi.nlm.nih.gov/32178401/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,24150846,Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy.,2014,10.1093/hmg/ddt527,https://pubmed.ncbi.nlm.nih.gov/24150846/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,21057542,Evidence of a role for the novel zinc-finger transcription factor ZKSCAN3 in modulating Cyclin D2 expression in multiple myeloma.,2011,10.1038/onc.2010.515,https://pubmed.ncbi.nlm.nih.gov/21057542/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,30335591,Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.,2019,10.1080/15548627.2018.1535292,https://pubmed.ncbi.nlm.nih.gov/30335591/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZKSCAN3,ENSG00000189298,Unsafe,22529291,"Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides.",2012,10.1182/blood-2012-01-405977,https://pubmed.ncbi.nlm.nih.gov/22529291/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYM5,ENSG00000132950,Unsafe,34256840,"The relative expression of miR-31, miR-29, miR-126, and miR-17 and their mRNA targets in the serum of COVID-19 patients with different grades during hospitalization.",2021,10.1186/s40001-021-00544-4,https://pubmed.ncbi.nlm.nih.gov/34256840/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYM5,ENSG00000132950,Unsafe,17126306,"Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERM.",2007,10.1016/j.brainres.2006.10.056,https://pubmed.ncbi.nlm.nih.gov/17126306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYM5,ENSG00000132950,Unsafe,26429724,GNL3 and SKA3 are novel prostate cancer metastasis susceptibility genes.,2015,10.1007/s10585-015-9745-y,https://pubmed.ncbi.nlm.nih.gov/26429724/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYM5,ENSG00000132950,Unsafe,23145142,SUMOylation of GTF2IRD1 regulates protein partner interactions and ubiquitin-mediated degradation.,2012,10.1371/journal.pone.0049283,https://pubmed.ncbi.nlm.nih.gov/23145142/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYM5,ENSG00000132950,Unsafe,22607268,Repression of transcription of presenilin-1 inhibits γ-secretase independent ER Ca²⁺ leak that is impaired by FAD mutations.,2012,10.1111/j.1471-4159.2012.07794.x,https://pubmed.ncbi.nlm.nih.gov/22607268/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYM5,ENSG00000132950,Unsafe,10894931,"Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11-->q12.",2000,10.1159/000015584,https://pubmed.ncbi.nlm.nih.gov/10894931/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYM5,ENSG00000132950,Unsafe,20036849,Transcriptional regulation of the presenilin-1 gene controls gamma-secretase activity.,2010,10.2741/e61,https://pubmed.ncbi.nlm.nih.gov/20036849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYM6,ENSG00000163867,Unsafe,38469237,Oncopig bladder cancer cells recapitulate human bladder cancer treatment responses in vitro.,2024,10.3389/fonc.2024.1323422,https://pubmed.ncbi.nlm.nih.gov/38469237/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYM6,ENSG00000163867,Unsafe,37239897,Characterization of Systemic and Culprit-Coronary Artery miR-483-5p Expression in Chronic CAD and Acute Myocardial Infarction Male Patients.,2023,10.3390/ijms24108551,https://pubmed.ncbi.nlm.nih.gov/37239897/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYM6,ENSG00000163867,Unsafe,32025240,Host proteome linked to HPV E7-mediated specific gene hypermethylation in cancer pathways.,2020,10.1186/s13027-020-0271-4,https://pubmed.ncbi.nlm.nih.gov/32025240/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYM6,ENSG00000163867,Unsafe,25133527,Characterization of the SUMO-binding activity of the myeloproliferative and mental retardation (MYM)-type zinc fingers in ZNF261 and ZNF198.,2014,10.1371/journal.pone.0105271,https://pubmed.ncbi.nlm.nih.gov/25133527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYM6,ENSG00000163867,Unsafe,24098497,Concurrent gene signatures for han chinese breast cancers.,2013,10.1371/journal.pone.0076421,https://pubmed.ncbi.nlm.nih.gov/24098497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYM6,ENSG00000163867,Unsafe,10486218,Cloning and mapping of members of the MYM family.,1999,10.1006/geno.1999.5918,https://pubmed.ncbi.nlm.nih.gov/10486218/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,42180707,A homozygous splice-site variant in &lt;i&gt;ZMYND10&lt;/i&gt; causes primary ciliary dyskinesia with primary infertility in a Chinese family.,2026,10.3389/fmed.2026.1838497,https://pubmed.ncbi.nlm.nih.gov/42180707/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,42278056,Single-Cell RNA Sequencing Reveals Dynamic Transcriptional Landscape of Testicular Maturation in Dezhou Donkeys.,2026,10.3390/ani16111621,https://pubmed.ncbi.nlm.nih.gov/42278056/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,41413096,Zmynd10 drives centriole biogenesis and multiciliogenesis through the transcriptional regulation of E2f4.,2025,10.1038/s41598-025-27956-0,https://pubmed.ncbi.nlm.nih.gov/41413096/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,42695096,Identification of NETs and inflammation-related prognostic genes in breast cancer and PCR experimental validation.,2026,10.3389/fgene.2026.1900298,https://pubmed.ncbi.nlm.nih.gov/42695096/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,40558543,Molecular Insights into Outer Dynein Arm Defects in Primary Ciliary Dyskinesia: Involvement of ZMYND10 and GRP78.,2025,10.3390/cells14120916,https://pubmed.ncbi.nlm.nih.gov/40558543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,41850444,Benzo[a]pyrene lowers the sperm quality in male rats by downregulating the expression of ZMYND15 and ZMYND10.,2026,10.1016/j.reprotox.2026.109225,https://pubmed.ncbi.nlm.nih.gov/41850444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,42072084,Transcriptomic Analysis of Fermented Chinese Chive Selectively Attenuating Deoxynivalenol-Induced Ovarian Toxicity in Mice.,2026,10.3390/antiox15040442,https://pubmed.ncbi.nlm.nih.gov/42072084/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,38798119,Sodium arsenite impairs sperm quality via downregulating the ZMYND15 and ZMYND10.,2024,10.1002/tox.24327,https://pubmed.ncbi.nlm.nih.gov/38798119/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,40591047,Identification of key biomarkers and potential therapeutic drugs in nasopharyngeal carcinoma based on comprehensive bioinformatics analysis.,2025,10.1007/s12672-025-03047-4,https://pubmed.ncbi.nlm.nih.gov/40591047/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,42374002,Development and validation of a novel T cell exhaustion-related signature to predict prognosis in patients with breast cancer.,2026,10.1007/s12672-026-05460-9,https://pubmed.ncbi.nlm.nih.gov/42374002/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,41377584,Enhanced oral nanomedicine utilizing biomineralized oncolytic virus for synergistic gastrointestinal cancer therapy.,2025,10.1016/j.mtbio.2025.102583,https://pubmed.ncbi.nlm.nih.gov/41377584/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,39634417,Novel bioinformatic approaches show the role of driver genes in the progression of cervical cancer: An in-silico study.,2024,10.1016/j.heliyon.2024.e40179,https://pubmed.ncbi.nlm.nih.gov/39634417/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,39180133,Characterization of pathogenic genetic variants in Russian patients with primary ciliary dyskinesia using gene panel sequencing and transcript analysis.,2024,10.1186/s13023-024-03318-3,https://pubmed.ncbi.nlm.nih.gov/39180133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,36520265,Zinc finger myeloid Nervy DEAF-1 type (ZMYND) domain containing proteins exert molecular interactions to implicate in carcinogenesis.,2022,10.1007/s12672-022-00597-9,https://pubmed.ncbi.nlm.nih.gov/36520265/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,29601588,ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms.,2018,10.1371/journal.pgen.1007316,https://pubmed.ncbi.nlm.nih.gov/29601588/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,40371404,Primary ciliary dyskinesia: a case report of double DNAH11 mutant alleles.,2025,10.15386/mpr-2743,https://pubmed.ncbi.nlm.nih.gov/40371404/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,35065333,Silencing of ciliary protein ZMYND10 affects amitotic macronucleus division in Paramecium tetraurelia.,2022,10.1016/j.ejop.2021.125863,https://pubmed.ncbi.nlm.nih.gov/35065333/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,31801619,"ZMYND10, an epigenetically regulated tumor suppressor, exerts tumor-suppressive functions via miR145-5p/NEDD9 axis in breast cancer.",2019,10.1186/s13148-019-0785-z,https://pubmed.ncbi.nlm.nih.gov/31801619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,35637434,Key gene network related to primary ciliary dyskinesia in hippocampus of patients with Alzheimer's disease revealed by weighted gene co-expression network analysis.,2022,10.1186/s12883-022-02724-z,https://pubmed.ncbi.nlm.nih.gov/35637434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,29916806,ZMYND10 functions in a chaperone relay during axonemal dynein assembly.,2018,10.7554/elife.34389,https://pubmed.ncbi.nlm.nih.gov/29916806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,42054806,Prenatal metal exposure moderates the effect of CRH-related DNA methylation in the placenta on infant communication outcomes at 2 months of age.,2026,10.1016/j.ecoenv.2026.120190,https://pubmed.ncbi.nlm.nih.gov/42054806/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,34664875,Identifying key genes and small molecule compounds for nasopharyngeal carcinoma by various bioinformatic analysis.,2021,10.1097/md.0000000000027257,https://pubmed.ncbi.nlm.nih.gov/34664875/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,32271791,DNA methylation biomarkers for nasopharyngeal carcinoma.,2020,10.1371/journal.pone.0230524,https://pubmed.ncbi.nlm.nih.gov/32271791/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,34508138,"An integrated analysis of mRNAs, lncRNAs, and miRNAs based on weighted gene co-expression network analysis involved in bovine endometritis.",2021,10.1038/s41598-021-97319-y,https://pubmed.ncbi.nlm.nih.gov/34508138/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,33635866,Defects in the cytoplasmic assembly of axonemal dynein arms cause morphological abnormalities and dysmotility in sperm cells leading to male infertility.,2021,10.1371/journal.pgen.1009306,https://pubmed.ncbi.nlm.nih.gov/33635866/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND10,ENSG00000004838,Unsafe,23604077,Identification of cilia genes that affect cell-cycle progression using whole-genome transcriptome analysis in Chlamydomonas reinhardtti.,2013,10.1534/g3.113.006338,https://pubmed.ncbi.nlm.nih.gov/23604077/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND12,ENSG00000066185,Unsafe,39066891,ZMYND12 serves as an IDAd subunit that is essential for sperm motility in mice.,2024,10.1007/s00018-024-05344-7,https://pubmed.ncbi.nlm.nih.gov/39066891/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND12,ENSG00000066185,Unsafe,37934199,"Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function.",2023,10.7554/elife.87698,https://pubmed.ncbi.nlm.nih.gov/37934199/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND12,ENSG00000066185,Unsafe,42039311,Selection signatures on the autosomes and the X chromosome in the prolific Belclare sheep breed.,2026,10.1016/j.vas.2026.100659,https://pubmed.ncbi.nlm.nih.gov/42039311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND12,ENSG00000066185,Unsafe,40926514,Polystyrene Nanoparticles Induce Transcriptional Repression in TM4 Sertoli Cells.,2026,10.1002/jat.4925,https://pubmed.ncbi.nlm.nih.gov/40926514/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND12,ENSG00000066185,Unsafe,36533556,Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants.,2022,10.1242/dmm.049568,https://pubmed.ncbi.nlm.nih.gov/36533556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND15,ENSG00000141497,Unsafe,42522282,Novel mutations in ZMYND15 expand the phenotypic spectrum to acephalic spermatozoa: abnormal sperm head-tail connection mediated by SUN5.,2026,10.4103/aja2025109,https://pubmed.ncbi.nlm.nih.gov/42522282/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND15,ENSG00000141497,Unsafe,41850444,Benzo[a]pyrene lowers the sperm quality in male rats by downregulating the expression of ZMYND15 and ZMYND10.,2026,10.1016/j.reprotox.2026.109225,https://pubmed.ncbi.nlm.nih.gov/41850444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND15,ENSG00000141497,Unsafe,40240737,Novel mutations in ZMYND15 are associated with male infertility with oligozoospermia/azoospermia.,2025,10.1007/s10815-025-03480-y,https://pubmed.ncbi.nlm.nih.gov/40240737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND15,ENSG00000141497,Unsafe,38798119,Sodium arsenite impairs sperm quality via downregulating the ZMYND15 and ZMYND10.,2024,10.1002/tox.24327,https://pubmed.ncbi.nlm.nih.gov/38798119/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND15,ENSG00000141497,Unsafe,40376536,Establishment and clinical significance of genetic factor screening method for patients with nonobstructive azoospermia based on whole exon sequencing technology.,2025,10.21037/tau-2024-676,https://pubmed.ncbi.nlm.nih.gov/40376536/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND15,ENSG00000141497,Unsafe,35017390,"From azoospermia to macrozoospermia, a phenotypic continuum due to mutations in the ZMYND15 gene.",2022,10.4103/aja202194,https://pubmed.ncbi.nlm.nih.gov/35017390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND15,ENSG00000141497,Unsafe,40765861,Deciphering the molecular signatures of tropical &lt;i&gt;Areca catechu&lt;/i&gt; L. under cold stress: an integrated physiological and transcriptomic analysis.,2025,10.3389/fpls.2025.1624335,https://pubmed.ncbi.nlm.nih.gov/40765861/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND15,ENSG00000141497,Unsafe,35973810,Sequencing of the ZMYND15 gene in a cohort of infertile Chinese men reveals novel mutations in patients with teratozoospermia.,2023,10.1136/jmg-2022-108727,https://pubmed.ncbi.nlm.nih.gov/35973810/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND15,ENSG00000141497,Unsafe,30054974,"Among seven testis-specific molecular markers, SPEM1 appears to have a significant clinical value for prediction of sperm retrieval in azoospermic men.",2018,10.1111/andr.12528,https://pubmed.ncbi.nlm.nih.gov/30054974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND15,ENSG00000141497,Unsafe,30577348,Re: Expression of ZMYND15 in Testes of Azoospermic Men and Association with Sperm Retrieval.,2019,10.1097/01.ju.0000550121.17952.1f,https://pubmed.ncbi.nlm.nih.gov/30577348/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND15,ENSG00000141497,Unsafe,36836593,Identification of Five Tumor Antigens for Development and Two Immune Subtypes for Personalized Medicine of mRNA Vaccines in Papillary Renal Cell Carcinoma.,2023,10.3390/jpm13020359,https://pubmed.ncbi.nlm.nih.gov/36836593/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND15,ENSG00000141497,Unsafe,31793700,"Could analysis of testis-specific genes, as biomarkers in seminal plasma, predict presence of focal spermatogenesis in non-obstructive azoospermia?",2020,10.1111/and.13483,https://pubmed.ncbi.nlm.nih.gov/31793700/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND15,ENSG00000141497,Unsafe,29305944,Expression of ZMYND15 in Testes of Azoospermic Men and Association With Sperm Retrieval.,2018,10.1016/j.urology.2017.12.023,https://pubmed.ncbi.nlm.nih.gov/29305944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND15,ENSG00000141497,Unsafe,32655042,Next-generation sequencing: toward an increase in the diagnostic yield in patients with apparently idiopathic spermatogenic failure.,2021,10.4103/aja.aja_25_20,https://pubmed.ncbi.nlm.nih.gov/32655042/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND15,ENSG00000141497,Unsafe,30697164,Transcriptomic Analysis Reveals Insights on Male Infertility in Octopus maya Under Chronic Thermal Stress.,2018,10.3389/fphys.2018.01920,https://pubmed.ncbi.nlm.nih.gov/30697164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND15,ENSG00000141497,Unsafe,20675388,Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility.,2010,10.1074/jbc.m110.116418,https://pubmed.ncbi.nlm.nih.gov/20675388/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZMYND15,ENSG00000141497,Unsafe,24431330,Truncating mutations in TAF4B and ZMYND15 causing recessive azoospermia.,2014,10.1136/jmedgenet-2013-102102,https://pubmed.ncbi.nlm.nih.gov/24431330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,42777717,"CRISPR-associated enzymes are mislocalized to the cytoplasm in iPSC-derived neurons, resulting in KRAB(KOX1)-specific degradation.",2026,10.1016/j.cels.2026.101737,https://pubmed.ncbi.nlm.nih.gov/42777717/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,40270035,CRISPR/Cas-mediated mRNA knockdown in the embryos of Xenopus tropicalis.,2025,10.1186/s13578-025-01397-8,https://pubmed.ncbi.nlm.nih.gov/40270035/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,39368466,The H3.3K36M oncohistone disrupts the establishment of epigenetic memory through loss of DNA methylation.,2024,10.1016/j.molcel.2024.09.015,https://pubmed.ncbi.nlm.nih.gov/39368466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,38745667,Human regulatory memory B cells defined by expression of TIM-1 and TIGIT are dysfunctional in multiple sclerosis.,2024,10.3389/fimmu.2024.1360219,https://pubmed.ncbi.nlm.nih.gov/38745667/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,31938422,The clinicopathological significance of ZNF10 in invasive ductal carcinoma of the breast.,2018,,https://pubmed.ncbi.nlm.nih.gov/31938422/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,37680368,Quantifying the arms race between LINE-1 and KRAB-zinc finger genes through TECookbook.,2023,10.1093/nargab/lqad078,https://pubmed.ncbi.nlm.nih.gov/37680368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,35162997,The KRAB Domain of ZNF10 Guides the Identification of Specific Amino Acids That Transform the Ancestral KRAB-A-Related Domain Present in Human PRDM9 into a Canonical Modern KRAB-A Domain.,2022,10.3390/ijms23031072,https://pubmed.ncbi.nlm.nih.gov/35162997/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,38925484,Investigating SARS-CoV-2 virus-host interactions and mRNA expression: Insights using three models of D. melanogaster.,2024,10.1016/j.bbadis.2024.167324,https://pubmed.ncbi.nlm.nih.gov/38925484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,31856708,"DUF3669, a ""domain of unknown function"" within ZNF746 and ZNF777, oligomerizes and contributes to transcriptional repression.",2019,10.1186/s12860-019-0243-y,https://pubmed.ncbi.nlm.nih.gov/31856708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,24498343,The B-subdomain of the Xenopus laevis XFIN KRAB-AB domain is responsible for its weaker transcriptional repressor activity compared to human ZNF10/Kox1.,2014,10.1371/journal.pone.0087609,https://pubmed.ncbi.nlm.nih.gov/24498343/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,33881484,Centromeric transcription maintains centromeric cohesion in human cells.,2021,10.1083/jcb.202008146,https://pubmed.ncbi.nlm.nih.gov/33881484/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,27600816,Deimmunization for gene therapy: host matching of synthetic zinc finger constructs enables long-term mutant Huntingtin repression in mice.,2016,10.1186/s13024-016-0128-x,https://pubmed.ncbi.nlm.nih.gov/27600816/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,26096782,ZNF10 inhibits HIV-1 LTR activity through interaction with NF-κB and Sp1 binding motifs.,2015,10.1016/j.febslet.2015.06.013,https://pubmed.ncbi.nlm.nih.gov/26096782/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,31180552,Characterization of a prognostic four‑gene methylation signature associated with radiotherapy for head and neck squamous cell carcinoma.,2019,10.3892/mmr.2019.10294,https://pubmed.ncbi.nlm.nih.gov/31180552/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,22406832,Genome-wide studies of the multi-zinc finger Drosophila Suppressor of Hairy-wing protein in the ovary.,2012,10.1093/nar/gks225,https://pubmed.ncbi.nlm.nih.gov/22406832/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,11405226,Transcriptional repression mediated by the KRAB domain of the human C2H2 zinc finger protein Kox1/ZNF10 does not require histone deacetylation.,2001,10.1515/bc.2001.075,https://pubmed.ncbi.nlm.nih.gov/11405226/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,9016654,Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1.,1996,10.1093/nar/24.24.4859,https://pubmed.ncbi.nlm.nih.gov/9016654/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,9278146,"Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Krüppel-type zinc finger factor.",1997,10.1515/bchm.1997.378.7.669,https://pubmed.ncbi.nlm.nih.gov/9278146/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,26833727,Structural basis for human PRDM9 action at recombination hot spots.,2016,10.1101/gad.274928.115,https://pubmed.ncbi.nlm.nih.gov/26833727/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,20600328,Development of cell cultures that express hepatitis B virus to high levels and accumulate cccDNA.,2010,10.1016/j.jviromet.2010.06.015,https://pubmed.ncbi.nlm.nih.gov/20600328/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,37212595,In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing.,2023,10.3791/64403,https://pubmed.ncbi.nlm.nih.gov/37212595/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,12574502,Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors.,2003,10.1073/pnas.252770699,https://pubmed.ncbi.nlm.nih.gov/12574502/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,2288909,Multiple genes encoding zinc finger domains are expressed in human T cells.,1990,,https://pubmed.ncbi.nlm.nih.gov/2288909/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,1946370,Characterization and mapping of human genes encoding zinc finger proteins.,1991,10.1073/pnas.88.21.9563,https://pubmed.ncbi.nlm.nih.gov/1946370/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF10,ENSG00000256223,Unsafe,8723389,From repression domains to designer zinc finger proteins: a novel strategy of intracellular immunization against HIV.,1996,,https://pubmed.ncbi.nlm.nih.gov/8723389/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF101,ENSG00000181896,Unsafe,42038348,Unveiling the prognostic and immunotherapeutic role of Tregs in lung cancer using integrated analysis of single-cell and bulk RNA-sequencing.,2026,10.3892/ol.2026.15588,https://pubmed.ncbi.nlm.nih.gov/42038348/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF101,ENSG00000181896,Unsafe,39782688,"Casz1 and Znf101/Zfp961 differentially regulate apolipoproteins A1 and B, alter plasma lipoproteins, and reduce atherosclerosis.",2025,10.1172/jci.insight.182260,https://pubmed.ncbi.nlm.nih.gov/39782688/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF101,ENSG00000181896,Unsafe,40520613,Construction of epilepsy diagnosis model based on cell senescence-related genes and its potential mechanism.,2025,10.3389/fneur.2025.1555586,https://pubmed.ncbi.nlm.nih.gov/40520613/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF101,ENSG00000181896,Unsafe,41085794,A prognostic model for gastric cancer constructed by multiple machine learning algorithms.,2025,10.1007/s10735-025-10629-7,https://pubmed.ncbi.nlm.nih.gov/41085794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF101,ENSG00000181896,Unsafe,41137279,ZNF143 as a diagnostic biomarker: Insights from gene expression and immune cell infiltration in COPD and asthma.,2025,10.1097/md.0000000000045317,https://pubmed.ncbi.nlm.nih.gov/41137279/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF101,ENSG00000181896,Unsafe,39854379,Identification of hypertension gene expression biomarkers based on the DeepGCFS algorithm.,2025,10.1371/journal.pone.0314319,https://pubmed.ncbi.nlm.nih.gov/39854379/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF101,ENSG00000181896,Unsafe,38767974,Identification of ion channel-related genes as diagnostic markers and potential therapeutic targets for osteoarthritis through bioinformatics and machine learning-based approaches.,2024,10.1080/1354750x.2024.2358316,https://pubmed.ncbi.nlm.nih.gov/38767974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF101,ENSG00000181896,Unsafe,34956196,Long Non-Coding RNA- Associated Competing Endogenous RNA Axes in T-Cells in Multiple Sclerosis.,2021,10.3389/fimmu.2021.770679,https://pubmed.ncbi.nlm.nih.gov/34956196/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF101,ENSG00000181896,Unsafe,33676152,A comparative genomic database of skeletogenesis genes: from fish to mammals.,2021,10.1016/j.cbd.2021.100796,https://pubmed.ncbi.nlm.nih.gov/33676152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF101,ENSG00000181896,Unsafe,31889940,The plasma peptides of breast versus ovarian cancer.,2019,10.1186/s12014-019-9262-0,https://pubmed.ncbi.nlm.nih.gov/31889940/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF101,ENSG00000181896,Unsafe,14727140,A novel Krüppel-Associated Box identified in a panel of mammalian zinc finger proteins.,2004,10.1007/s00335-003-3022-0,https://pubmed.ncbi.nlm.nih.gov/14727140/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF112,ENSG00000062370,Unsafe,36081762,The Associated of the Risk of IVIG Resistance in Kawasaki Disease with ZNF112 Gene and ZNF180 Gene in a Southern Chinese Population.,2022,10.2147/jir.s378080,https://pubmed.ncbi.nlm.nih.gov/36081762/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF112,ENSG00000062370,Unsafe,39955954,Feature gene selection and functional validation of SH3KBP1 in infantile hemangioma using machine learning.,2025,10.1016/j.bbrc.2025.151469,https://pubmed.ncbi.nlm.nih.gov/39955954/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF112,ENSG00000062370,Unsafe,17942098,Differential display analysis of gene expression in female-to-male sex-reversing gonads of the frog Rana rugosa.,2008,10.1016/j.ygcen.2007.08.015,https://pubmed.ncbi.nlm.nih.gov/17942098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF124,ENSG00000196418,Unsafe,41708596,Unveiling ZNF124 as a novel determinant in neurodegeneration: orchestration of photoreceptor homeostasis through MSX2 transcriptional regulation.,2026,10.1038/s41419-026-08487-6,https://pubmed.ncbi.nlm.nih.gov/41708596/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF124,ENSG00000196418,Unsafe,39744172,HPV-Associated Gene Signatures in Bladder Cancer: A Comprehensive Prognostic Model and its Implications in Immunotherapy.,2025,10.7150/ijms.98334,https://pubmed.ncbi.nlm.nih.gov/39744172/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF124,ENSG00000196418,Unsafe,33681213,Genomic and Transcriptomic Analyses Reveals ZNF124 as a Critical Regulator in Highly Aggressive Medulloblastomas.,2021,10.3389/fcell.2021.634056,https://pubmed.ncbi.nlm.nih.gov/33681213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF124,ENSG00000196418,Unsafe,33186139,Circ-ZNF124 downregulation inhibits non-small cell lung cancer progression partly by inactivating the Wnt/β-catenin signaling pathway via mediating the miR-498/YES1 axis.,2021,10.1097/cad.0000000000001014,https://pubmed.ncbi.nlm.nih.gov/33186139/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF124,ENSG00000196418,Unsafe,29545821,Maternal 5mCpG Imprints at the PARD6G-AS1 and GCSAML Differentially Methylated Regions Are Decoupled From Parent-of-Origin Expression Effects in Multiple Human Tissues.,2018,10.3389/fgene.2018.00036,https://pubmed.ncbi.nlm.nih.gov/29545821/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF124,ENSG00000196418,Unsafe,37098643,Genome-wide analysis toward the epigenetic aetiology of myelodysplastic syndrome disease progression and pharmacoepigenomic basis of hypomethylating agents drug treatment response.,2023,10.1186/s40246-023-00483-7,https://pubmed.ncbi.nlm.nih.gov/37098643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF124,ENSG00000196418,Unsafe,23874428,Reconstruction of an integrated genome-scale co-expression network reveals key modules involved in lung adenocarcinoma.,2013,10.1371/journal.pone.0067552,https://pubmed.ncbi.nlm.nih.gov/23874428/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF124,ENSG00000196418,Unsafe,20382278,"Four patients with speech delay, seizures and variable corpus callosum thickness sharing a 0.440 Mb deletion in region 1q44 containing the HNRPU gene.",2010,10.1016/j.ejmg.2010.04.001,https://pubmed.ncbi.nlm.nih.gov/20382278/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF124,ENSG00000196418,Unsafe,17431901,Dandy-Walker complex in a boy with a 5 Mb deletion of region 1q44 due to a paternal t(1;20)(q44;q13.33).,2007,10.1002/ajmg.a.31690,https://pubmed.ncbi.nlm.nih.gov/17431901/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,39865831,ZNF165: A Pan-Cancer Biomarker with Prognostic and Therapeutic Potential.,2025,10.2174/0109298665351592250106062250,https://pubmed.ncbi.nlm.nih.gov/39865831/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,41878416,AI-derived prognostic model identifies high-risk gene signatures in pediatric gliomas.,2026,10.3389/fimmu.2026.1704720,https://pubmed.ncbi.nlm.nih.gov/41878416/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,35692498,ZNF165 Is Involved in the Regulation of Immune Microenvironment and Promoting the Proliferation and Migration of Hepatocellular Carcinoma by AhR/CYP1A1.,2022,10.1155/2022/4446805,https://pubmed.ncbi.nlm.nih.gov/35692498/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,39624211,Identification of a Novel Mesenchymal Stem Cell-Related Signature for Predicting the Prognosis and Therapeutic Responses of Bladder Cancer.,2024,10.1155/sci/6064671,https://pubmed.ncbi.nlm.nih.gov/39624211/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,32515734,The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer.,2020,10.7554/elife.57679,https://pubmed.ncbi.nlm.nih.gov/32515734/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,37324016,Construction of T cell exhaustion model for predicting survival and immunotherapy effect of bladder cancer based on WGCNA.,2023,10.3389/fonc.2023.1196802,https://pubmed.ncbi.nlm.nih.gov/37324016/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,37994325,Identification of Potential Genes and Critical Pathways in Postoperative Recurrence of Crohn's Disease by Machine Learning And WGCNA Network Analysis.,2023,10.2174/1389202924666230601122334,https://pubmed.ncbi.nlm.nih.gov/37994325/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,35974335,PredictiveNetwork: predictive gene network estimation with application to gastric cancer drug response-predictive network analysis.,2022,10.1186/s12859-022-04871-z,https://pubmed.ncbi.nlm.nih.gov/35974335/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,25214475,Frequent expression of zinc-finger protein ZNF165 in human urinary bladder transitional cell carcinoma.,2015,10.1016/j.imbio.2014.08.018,https://pubmed.ncbi.nlm.nih.gov/25214475/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,26567849,Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer.,2015,10.1038/ncomms9840,https://pubmed.ncbi.nlm.nih.gov/26567849/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,15354214,Zinc-finger protein ZNF165 is a novel cancer-testis antigen capable of eliciting antibody response in hepatocellular carcinoma patients.,2004,10.1038/sj.bjc.6602138,https://pubmed.ncbi.nlm.nih.gov/15354214/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,31953506,Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients.,2020,10.1038/s41598-019-57358-y,https://pubmed.ncbi.nlm.nih.gov/31953506/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,27295129,"Investigating core genetic-and-epigenetic cell cycle networks for stemness and carcinogenic mechanisms, and cancer drug design using big database mining and genome-wide next-generation sequencing data.",2016,10.1080/15384101.2016.1198862,https://pubmed.ncbi.nlm.nih.gov/27295129/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,16929165,Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma.,2006,10.4161/cbt.5.9.3174,https://pubmed.ncbi.nlm.nih.gov/16929165/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,7490084,Characterization of a novel zinc finger gene (ZNF165) mapping to 6p21 that is expressed specifically in testis.,1995,10.1006/geno.1995.1178,https://pubmed.ncbi.nlm.nih.gov/7490084/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,18990219,A new 500 kb haplotype associated with high CD8+ T-lymphocyte numbers predicts a less severe expression of hereditary hemochromatosis.,2008,10.1186/1471-2350-9-97,https://pubmed.ncbi.nlm.nih.gov/18990219/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,11076058,Familial t(6;21)(p21.1;p13) translocation associated with male-only sterility.,2000,10.1034/j.1399-0004.2000.580411.x,https://pubmed.ncbi.nlm.nih.gov/11076058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,9244436,Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain.,1997,10.1006/geno.1997.4806,https://pubmed.ncbi.nlm.nih.gov/9244436/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF165,ENSG00000197279,Unsafe,23082221,Genome-wide association identifies multiple genomic regions associated with susceptibility to and control of ovine lentivirus.,2012,10.1371/journal.pone.0047829,https://pubmed.ncbi.nlm.nih.gov/23082221/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF169,ENSG00000175787,Unsafe,42087894,Whole-Exome Sequencing to Screen Personal Neoantigens With High Immunogenicity in Patients With Microsatellite Stability (MSS)-Advanced Colorectal Cancer.,2026,10.1155/humu/3876230,https://pubmed.ncbi.nlm.nih.gov/42087894/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF169,ENSG00000175787,Unsafe,39875985,ZNF169 promotes thyroid cancer progression via upregulating FBXW10.,2025,10.1186/s13008-024-00139-5,https://pubmed.ncbi.nlm.nih.gov/39875985/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF169,ENSG00000175787,Unsafe,38666541,Overexpression of ZNF169 promotes the growth and proliferation of colorectal cancer cells via the upregulation of ANKZF1.,2024,10.3892/or.2024.8741,https://pubmed.ncbi.nlm.nih.gov/38666541/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF169,ENSG00000175787,Unsafe,39868893,Zinc finger protein 169 promotes tumor progress of hepatocellular cancer via up-regulating cyclin-dependent kinase 19.,2025,10.1002/iub.2943,https://pubmed.ncbi.nlm.nih.gov/39868893/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF169,ENSG00000175787,Unsafe,38314503,piRNAs in the human retina and retinal pigment epithelium reveal a potential role in intracellular trafficking and oxidative stress.,2024,10.1039/d3mo00122a,https://pubmed.ncbi.nlm.nih.gov/38314503/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF169,ENSG00000175787,Unsafe,34716342,Refining models of archaic admixture in Eurasia with ArchaicSeeker 2.0.,2021,10.1038/s41467-021-26503-5,https://pubmed.ncbi.nlm.nih.gov/34716342/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF169,ENSG00000175787,Unsafe,29273807,Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.,2018,10.1038/s41588-017-0011-x,https://pubmed.ncbi.nlm.nih.gov/29273807/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF169,ENSG00000175787,Unsafe,16170343,"The elusive multiple self-healing squamous epithelioma (MSSE) gene: further mapping, analysis of candidates, and loss of heterozygosity.",2006,10.1038/sj.onc.1209092,https://pubmed.ncbi.nlm.nih.gov/16170343/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF174,ENSG00000103343,Unsafe,7673192,Isolation and characterization of a novel zinc-finger protein with transcription repressor activity.,1995,10.1074/jbc.270.38.22143,https://pubmed.ncbi.nlm.nih.gov/7673192/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF174,ENSG00000103343,Unsafe,11741982,The SCAN domain of ZNF174 is a dimer.,2002,10.1074/jbc.m109815200,https://pubmed.ncbi.nlm.nih.gov/11741982/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF19,ENSG00000157429,Unsafe,1946370,Characterization and mapping of human genes encoding zinc finger proteins.,1991,10.1073/pnas.88.21.9563,https://pubmed.ncbi.nlm.nih.gov/1946370/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,40372915,GATA3 differentially regulates the transcriptome via zinc finger 2-modulated phase separation.,2025,10.1016/j.celrep.2025.115702,https://pubmed.ncbi.nlm.nih.gov/40372915/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,39475508,Alternative isoforms and phase separation of Ref1 repress morphogenesis in Cryptococcus.,2024,10.1016/j.celrep.2024.114904,https://pubmed.ncbi.nlm.nih.gov/39475508/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,40650643,EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells.,2025,10.1002/advs.202410243,https://pubmed.ncbi.nlm.nih.gov/40650643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,39946532,Identification of a protective antigen reveals the trade-off between iron acquisition and antigen exposure in a global fungal pathogen.,2025,10.1073/pnas.2420898122,https://pubmed.ncbi.nlm.nih.gov/39946532/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,37338404,Vaccination with a ZNF2oe Strain of Cryptococcus Provides Long-Lasting Protection against Cryptococcosis and Is Effective in Immunocompromised Hosts.,2023,10.1128/iai.00198-23,https://pubmed.ncbi.nlm.nih.gov/37338404/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,40634336,Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose.,2025,10.1038/s41467-025-61111-7,https://pubmed.ncbi.nlm.nih.gov/40634336/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,35012334,Immunoprotection against Cryptococcosis Offered by Znf2 Depends on Capsule and the Hyphal Morphology.,2022,10.1128/mbio.02785-21,https://pubmed.ncbi.nlm.nih.gov/35012334/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,38469092,"A novel GATA3 frameshift mutation causes hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome.",2024,10.1016/j.ymgmr.2024.101063,https://pubmed.ncbi.nlm.nih.gov/38469092/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,39238829,Identification and Validation of Hub Genes and Construction of miRNA-Gene and Transcription Factor-Gene Networks in Adipogenesis of Mesenchymal Stem Cells.,2024,10.1155/2024/5789593,https://pubmed.ncbi.nlm.nih.gov/39238829/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,37850793,Histone acetyltransferase Gcn5-mediated histone H3 acetylation facilitates cryptococcal morphogenesis and sexual reproduction.,2023,10.1128/msphere.00299-23,https://pubmed.ncbi.nlm.nih.gov/37850793/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,35865614,Deciphering the functional mechanism of zinc ions of PARP1 binding with single strand breaks and double strand breaks.,2022,10.1039/d2ra02683j,https://pubmed.ncbi.nlm.nih.gov/35865614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,39971753,Epigenome-wide association study of incident type 2 diabetes in Black and White participants from the Atherosclerosis Risk in Communities Study.,2025,10.1007/s00125-024-06352-9,https://pubmed.ncbi.nlm.nih.gov/39971753/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,38874410,Unraveling the cryptic functions of mitogen-activated protein kinases Cpk2 and Mpk2 in &lt;i&gt;Cryptococcus neoformans&lt;/i&gt;.,2024,10.1128/mbio.01156-24,https://pubmed.ncbi.nlm.nih.gov/38874410/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,39871739,Enhancing Zn Deposition Reversibility on MXene Current Collectors by Forming ZnF&lt;sub&gt;2&lt;/sub&gt;-Containing Solid-Electrolyte Interphase for Anode-Free Zinc Metal Batteries.,2026,10.1002/smll.202407226,https://pubmed.ncbi.nlm.nih.gov/39871739/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,32116123,The zinc finger domains in U2AF26 and U2AF35 have diverse functionalities including a role in controlling translation.,2020,10.1080/15476286.2020.1732701,https://pubmed.ncbi.nlm.nih.gov/32116123/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,31754642,Transcription factor Znf2 coordinates with the chromatin remodeling SWI/SNF complex to regulate cryptococcal cellular differentiation.,2019,10.1038/s42003-019-0665-2,https://pubmed.ncbi.nlm.nih.gov/31754642/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,39685243,Mechanism and Experimental Study on the Recovery of Rare Earth Elements from Neodymium Iron Boron Waste Using the ZnF2 Fluorination Method.,2024,10.3390/ma17235807,https://pubmed.ncbi.nlm.nih.gov/39685243/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,34719327,The distinct RNA-interaction modes of a small ZnF domain underlay TUT4(7) diverse action in miRNA regulation.,2021,10.1080/15476286.2021.1991169,https://pubmed.ncbi.nlm.nih.gov/34719327/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,30312653,Expression analysis and characterization of zglp1 in the Chinese tongue sole (Cynoglossus semilaevis).,2019,10.1016/j.gene.2018.10.003,https://pubmed.ncbi.nlm.nih.gov/30312653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,34944968,Epigenetic Deregulation of Telomere-Related Genes in Newly Diagnosed Multiple Myeloma Patients.,2021,10.3390/cancers13246348,https://pubmed.ncbi.nlm.nih.gov/34944968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,40167003,Fatty acid methyl ester ethoxylate additive for enhancing high-temperature aqueous zinc-ion battery performance.,2025,10.1063/5.0265189,https://pubmed.ncbi.nlm.nih.gov/40167003/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,36786396,Promising whole-cell vaccines against cryptococcosis.,2023,10.1111/1348-0421.13056,https://pubmed.ncbi.nlm.nih.gov/36786396/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,26443458,Development of protective inflammation and cell-mediated immunity against Cryptococcus neoformans after exposure to hyphal mutants.,2015,10.1128/mbio.01433-15,https://pubmed.ncbi.nlm.nih.gov/26443458/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,26892107,Risk Assessment Study of Fluoride Salts: Probability-Impact Matrix of Renal and Hepatic Toxicity Markers.,2016,10.1007/s12011-016-0644-0,https://pubmed.ncbi.nlm.nih.gov/26892107/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,24572004,Deposition of F-doped ZnO transparent thin films using ZnF2-doped ZnO target under different sputtering substrate temperatures.,2014,10.1186/1556-276x-9-97,https://pubmed.ncbi.nlm.nih.gov/24572004/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,23951221,A masked PY-NLS in Drosophila TIS11 and its mammalian homolog tristetraprolin.,2013,10.1371/journal.pone.0071686,https://pubmed.ncbi.nlm.nih.gov/23951221/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF2,ENSG00000275111,Unsafe,1945843,Members of the zinc finger protein gene family sharing a conserved N-terminal module.,1991,10.1093/nar/19.20.5661,https://pubmed.ncbi.nlm.nih.gov/1945843/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,42360372,Zinc finger protein-associated gene signature serves as a potential predictor for prognosis and therapeutic response in lung adenocarcinoma.,2026,10.1007/s00726-026-03528-y,https://pubmed.ncbi.nlm.nih.gov/42360372/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,39618843,High Expression of ZNF208 Predicts Better Prognosis and Suppresses the Tumorigenesis of Breast Cancer.,2024,10.1177/11795549241301341,https://pubmed.ncbi.nlm.nih.gov/39618843/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,41285996,Prognostic value assessment and in vitro validation of mitochondria-ferroptosis-related genes in multiple myeloma.,2025,10.1038/s41598-025-25476-5,https://pubmed.ncbi.nlm.nih.gov/41285996/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,39247597,Analysis of ZNF208 Polymorphisms on the Clinicopathologic Characteristics of Asian Patients with Hepatocellular Carcinoma.,2024,10.7150/jca.98520,https://pubmed.ncbi.nlm.nih.gov/39247597/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,40107556,Codon usage bias and nucleotide bias are not influenced by the 5' flanking but by 3' and intronic region composition in SCID-associated genes.,2025,10.1016/j.ijbiomac.2025.142182,https://pubmed.ncbi.nlm.nih.gov/40107556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,41668119,Relationship between genetically determined telomere length and childhood glioma risk.,2026,10.1186/s40478-025-02199-2,https://pubmed.ncbi.nlm.nih.gov/41668119/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,37528851,Identification of a miRNA-mRNA regulatory network for post-stroke depression: a machine-learning approach.,2023,10.3389/fneur.2023.1096911,https://pubmed.ncbi.nlm.nih.gov/37528851/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,35480322,Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male.,2022,10.3389/fgene.2022.813823,https://pubmed.ncbi.nlm.nih.gov/35480322/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,33921254,Telomere Length and Male Fertility.,2021,10.3390/ijms22083959,https://pubmed.ncbi.nlm.nih.gov/33921254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,32256782,Identification of DNA methylation-driven genes by integrative analysis of DNA methylation and transcriptome data in pancreatic adenocarcinoma.,2020,10.3892/etm.2020.8554,https://pubmed.ncbi.nlm.nih.gov/32256782/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,29100383,"Association between TNIP1, MPHOSPH6 and ZNF208 genetic polymorphisms and the coronary artery disease risk in Chinese Han population.",2017,10.18632/oncotarget.20432,https://pubmed.ncbi.nlm.nih.gov/29100383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,29348838,Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people.,2017,10.18632/oncotarget.19669,https://pubmed.ncbi.nlm.nih.gov/29348838/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,33892093,CircZNF208 enhances the sensitivity to X-rays instead of carbon-ions through the miR-7-5p /SNCA signal axis in non-small-cell lung cancer cells.,2021,10.1016/j.cellsig.2021.110012,https://pubmed.ncbi.nlm.nih.gov/33892093/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,27907911,Genetic variants in the ZNF208 gene are associated with esophageal cancer in a Chinese Han population.,2016,10.18632/oncotarget.13468,https://pubmed.ncbi.nlm.nih.gov/27907911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,28985021,The effects of gene polymorphisms on glioma prognosis.,2017,10.1002/jgm.2989,https://pubmed.ncbi.nlm.nih.gov/28985021/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,29883365,The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese.,2018,10.18632/aging.101461,https://pubmed.ncbi.nlm.nih.gov/29883365/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,27936511,ZNF208 polymorphisms associated with ischemic stroke in a southern Chinese Han population.,2017,10.1002/jgm.2937,https://pubmed.ncbi.nlm.nih.gov/27936511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,29151059,Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal.,2018,10.1136/jmedgenet-2017-104922,https://pubmed.ncbi.nlm.nih.gov/29151059/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,26330360,Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma.,2015,10.1038/srep13750,https://pubmed.ncbi.nlm.nih.gov/26330360/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,27197291,Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia.,2016,10.1158/1055-9965.epi-15-1329,https://pubmed.ncbi.nlm.nih.gov/27197291/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF208,ENSG00000160321,Unsafe,31388112,Association between common telomere length genetic variants and telomere length in an African population and impacts of HIV and TB.,2019,10.1038/s10038-019-0646-9,https://pubmed.ncbi.nlm.nih.gov/31388112/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF214,ENSG00000149050,Unsafe,30266865,Quantitative Proteomics of the Mitotic Chromosome Scaffold Reveals the Association of BAZ1B with Chromosomal Axes.,2019,10.1074/mcp.ra118.000923,https://pubmed.ncbi.nlm.nih.gov/30266865/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF214,ENSG00000149050,Unsafe,28253350,Sox10 contributes to the balance of fate choice in dorsal root ganglion progenitors.,2017,10.1371/journal.pone.0172947,https://pubmed.ncbi.nlm.nih.gov/28253350/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF214,ENSG00000149050,Unsafe,21448237,Reduced transcript expression of genes affected by inherited and de novo CNVs in autism.,2011,10.1038/ejhg.2011.24,https://pubmed.ncbi.nlm.nih.gov/21448237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF214,ENSG00000149050,Unsafe,20980787,Morphogenetic targets and genetics of undescended testis.,2010,10.1159/000321006,https://pubmed.ncbi.nlm.nih.gov/20980787/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF214,ENSG00000149050,Unsafe,22052655,"A novel familial 11p15.4 microduplication associated with intellectual disability, dysmorphic features, and obesity with involvement of the ZNF214 gene.",2012,10.1002/ajmg.a.34290,https://pubmed.ncbi.nlm.nih.gov/22052655/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF214,ENSG00000149050,Unsafe,12970396,Chromosomal region 11p15 is associated with male factor subfertility.,2003,10.1093/molehr/gag081,https://pubmed.ncbi.nlm.nih.gov/12970396/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF214,ENSG00000149050,Unsafe,10762538,"Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome.",2000,10.1086/302892,https://pubmed.ncbi.nlm.nih.gov/10762538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,42626597,Chemical tools for BAZ2A/B biology: discovery of dual and BAZ2B-selective PROTAC degraders.,2026,10.1039/d6md00244g,https://pubmed.ncbi.nlm.nih.gov/42626597/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,42510762,Integrated GWAS and eQTL Colocalization Identified Candidate Genes for Growth Traits in Pigs.,2026,10.3390/biology15141216,https://pubmed.ncbi.nlm.nih.gov/42510762/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,42285512,Structural insights into histone mimicry by the small hepatitis delta antigen.,2026,10.1016/j.jbc.2026.113252,https://pubmed.ncbi.nlm.nih.gov/42285512/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,41979565,BAZ2B contributes to endometrial fibrosis by promoting fibroblast-to-myofibroblast differentiation.,2026,10.1042/cs20250559,https://pubmed.ncbi.nlm.nih.gov/41979565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,40813973,Single-variant genome-wide association study and regional heritability mapping of protein efficiency and performance traits in Large White pigs.,2025,10.1186/s12711-025-00993-z,https://pubmed.ncbi.nlm.nih.gov/40813973/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,41296062,The oncogenic role of BCL2L12 associated with immune status in the prognosis of human hepatocellular carcinoma.,2025,10.1007/s00114-025-02040-9,https://pubmed.ncbi.nlm.nih.gov/41296062/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,37574751,Reevaluation of bromodomain ligands targeting BAZ2A.,2023,10.1002/pro.4752,https://pubmed.ncbi.nlm.nih.gov/37574751/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,35090595,In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration.,2022,10.1016/j.stem.2022.01.001,https://pubmed.ncbi.nlm.nih.gov/35090595/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,37920417,Altered expression of imprinted genes in patients with cytogenetically normal‑acute myeloid leukemia: Implications for leukemogenesis and survival outcomes.,2023,10.3892/mco.2023.2690,https://pubmed.ncbi.nlm.nih.gov/37920417/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,37260411,Bidirectional Mediation Effects between Intratumoral Microbiome and Host DNA Methylation Changes Contribute to Stomach Adenocarcinoma.,2023,10.1128/spectrum.00904-23,https://pubmed.ncbi.nlm.nih.gov/37260411/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,39810085,Genome-wide association study identifies candidate genes affecting body conformation traits of Zhongwei goat.,2025,10.1186/s12864-024-11097-1,https://pubmed.ncbi.nlm.nih.gov/39810085/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,34091126,Loss of ZNF215 imprinting is associated with poor five-year survival in patients with cytogenetically abnormal-acute myeloid leukemia.,2021,10.1016/j.bcmd.2021.102577,https://pubmed.ncbi.nlm.nih.gov/34091126/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,38268203,Analysis of histone H3K4me3 modifications in bovine placenta derived from different calf-production methods.,2024,10.1111/rda.14527,https://pubmed.ncbi.nlm.nih.gov/38268203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,35617710,A 2-bp deletion mutation in SMPD1 gene leading to lysosomal acid sphingomyelinase deficiency in a Chinese consanguineous pedigree.,2022,10.1515/jpem-2021-0480,https://pubmed.ncbi.nlm.nih.gov/35617710/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,31000582,"GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer.",2019,10.1158/1541-7786.mcr-18-1121,https://pubmed.ncbi.nlm.nih.gov/31000582/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,25719566,"Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B.",2015,10.1021/jm501963e,https://pubmed.ncbi.nlm.nih.gov/25719566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,20942903,DNA sequence polymorphisms in a panel of eight candidate bovine imprinted genes and their association with performance traits in Irish Holstein-Friesian cattle.,2010,10.1186/1471-2156-11-93,https://pubmed.ncbi.nlm.nih.gov/20942903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,25799074,"Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.",2016,10.1021/acs.jmedchem.5b00209,https://pubmed.ncbi.nlm.nih.gov/25799074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,27028820,[Identification of the Disease-Associated Genes in Periodontitis Using the Co-expression Network].,2016,10.7868/s0026898416010195,https://pubmed.ncbi.nlm.nih.gov/27028820/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,27402879,Parent-of-origin tumourigenesis is mediated by an essential imprinted modifier in SDHD-linked paragangliomas: SLC22A18 and CDKN1C are candidate tumour modifiers.,2016,10.1093/hmg/ddw218,https://pubmed.ncbi.nlm.nih.gov/27402879/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF215,ENSG00000149054,Unsafe,23025704,Generation and characterization of human cryptorchid-specific induced pluripotent stem cells from urine.,2013,10.1089/scd.2012.0260,https://pubmed.ncbi.nlm.nih.gov/23025704/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF223,ENSG00000178386,Unsafe,42131108,Identification of common genes associated with diabetic nephropathy and diabetic retinopathy.,2026,10.3389/fcell.2026.1808941,https://pubmed.ncbi.nlm.nih.gov/42131108/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF223,ENSG00000178386,Unsafe,36291758,Sentinel Lymph Node Gene Expression Signature Predicts Recurrence-Free Survival in Cutaneous Melanoma.,2022,10.3390/cancers14204973,https://pubmed.ncbi.nlm.nih.gov/36291758/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF223,ENSG00000178386,Unsafe,32795971,Deciphering Key Genes and miRNAs Associated With Hepatocellular Carcinoma via Network-Based Approach.,2022,10.1109/tcbb.2020.3016781,https://pubmed.ncbi.nlm.nih.gov/32795971/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF223,ENSG00000178386,Unsafe,24634323,Chromosome 19 rearrangements in ovarian carcinomas: zinc finger genes are particularly targeted.,2014,10.1002/gcc.22166,https://pubmed.ncbi.nlm.nih.gov/24634323/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF225,ENSG00000256294,Unsafe,42463670,Network-based discovery of regulatory drivers of cognitive decline in alzheimer's disease.,2026,10.1038/s41514-026-00443-0,https://pubmed.ncbi.nlm.nih.gov/42463670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF225,ENSG00000256294,Unsafe,41594224,The Whole Transcriptome Sequencing Profile of Serum-Derived Exosomes and Potential Pathophysiology of Age-Related Hearing Loss.,2026,10.3390/diagnostics16020248,https://pubmed.ncbi.nlm.nih.gov/41594224/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF225,ENSG00000256294,Unsafe,33799789,Combining Everolimus and Ku0063794 Promotes Apoptosis of Hepatocellular Carcinoma Cells via Reduced Autophagy Resulting from Diminished Expression of miR-4790-3p.,2021,10.3390/ijms22062859,https://pubmed.ncbi.nlm.nih.gov/33799789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF225,ENSG00000256294,Unsafe,38721148,Genetic changes in the &lt;i&gt;FH&lt;/i&gt; gene cause vagal paraganglioma.,2024,10.3389/fendo.2024.1381093,https://pubmed.ncbi.nlm.nih.gov/38721148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF225,ENSG00000256294,Unsafe,37013470,"Comprehensive analysis of ZNF family genes in prognosis, immunity, and treatment of esophageal cancer.",2023,10.1186/s12885-023-10779-5,https://pubmed.ncbi.nlm.nih.gov/37013470/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF225,ENSG00000256294,Unsafe,34149809,Leveraging Methylation Alterations to Discover Potential Causal Genes Associated With the Survival Risk of Cervical Cancer in TCGA Through a Two-Stage Inference Approach.,2021,10.3389/fgene.2021.667877,https://pubmed.ncbi.nlm.nih.gov/34149809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF227,ENSG00000131115,Unsafe,20553618,Differential gene expression in brain tissues of aggressive and non-aggressive dogs.,2010,10.1186/1746-6148-6-34,https://pubmed.ncbi.nlm.nih.gov/20553618/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF229,ENSG00000278318,Unsafe,36556252,Prediction of Cervical Cancer Outcome by Identifying and Validating a NAD+ Metabolism-Derived Gene Signature.,2022,10.3390/jpm12122031,https://pubmed.ncbi.nlm.nih.gov/36556252/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF229,ENSG00000278318,Unsafe,34778269,Targeted Bisulfite Sequencing Reveals DNA Methylation Changes in Zinc Finger Family Genes Associated With KRAS Mutated Colorectal Cancer.,2021,10.3389/fcell.2021.759813,https://pubmed.ncbi.nlm.nih.gov/34778269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF23,ENSG00000167377,Unsafe,41927046,Genome-wide association and Mendelian randomization analyses of placental efficiency and piglet birth weight in Danish Large White pigs.,2026,10.5713/ab.250992,https://pubmed.ncbi.nlm.nih.gov/41927046/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF23,ENSG00000167377,Unsafe,38396970,CD163-Mediated Small-Vessel Injury in Alzheimer's Disease: An Exploration from Neuroimaging to Transcriptomics.,2024,10.3390/ijms25042293,https://pubmed.ncbi.nlm.nih.gov/38396970/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF23,ENSG00000167377,Unsafe,34030136,Nucleolar small molecule RNA SNORA75 promotes endometrial receptivity by regulating the function of miR-146a-3p and ZNF23.,2021,10.18632/aging.203007,https://pubmed.ncbi.nlm.nih.gov/34030136/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF23,ENSG00000167377,Unsafe,34923485,Silencing of miR-1246 Induces Cell Cycle Arrest and Apoptosis in Cisplatin-Resistant Ovarian Cancer Cells by Promoting ZNF23 Transcription.,2021,10.1159/000520069,https://pubmed.ncbi.nlm.nih.gov/34923485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF23,ENSG00000167377,Unsafe,28848158,ZNF23 Suppresses Cutaneous Melanoma Cell Malignancy via Mitochondria-Dependent Pathway.,2017,10.1159/000480333,https://pubmed.ncbi.nlm.nih.gov/28848158/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF23,ENSG00000167377,Unsafe,33037855,Characterization of hepatitis B virus DNA integration patterns in intrahepatic cholangiocarcinoma.,2021,10.1111/hepr.13580,https://pubmed.ncbi.nlm.nih.gov/33037855/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF23,ENSG00000167377,Unsafe,21965783,Expression of zinc finger 23 gene in human hepatocellular carcinoma.,2011,,https://pubmed.ncbi.nlm.nih.gov/21965783/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF23,ENSG00000167377,Unsafe,17137575,"Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression.",2007,10.1016/j.yexcr.2006.10.009,https://pubmed.ncbi.nlm.nih.gov/17137575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF23,ENSG00000167377,Unsafe,18384939,ZNF23 induces apoptosis in human ovarian cancer cells.,2008,10.1016/j.canlet.2008.02.059,https://pubmed.ncbi.nlm.nih.gov/18384939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF23,ENSG00000167377,Unsafe,12127974,"Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development.",2002,10.1016/s0006-291x(02)00759-3,https://pubmed.ncbi.nlm.nih.gov/12127974/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF23,ENSG00000167377,Unsafe,22590624,Eukaryotic protein recruitment into the Chlamydia inclusion: implications for survival and growth.,2012,10.1371/journal.pone.0036843,https://pubmed.ncbi.nlm.nih.gov/22590624/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF230,ENSG00000159882,Unsafe,25505846,Targeted disruption of the mouse testis-enriched gene Znf230 does not affect spermatogenesis or fertility.,2014,10.1590/s1415-47572014005000013,https://pubmed.ncbi.nlm.nih.gov/25505846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF230,ENSG00000159882,Unsafe,23196134,A new mutant transcript generated in Znf230 exon 2 knockout mice reveals a potential exon structure in the targeting vector sequence.,2013,10.1093/abbs/gms101,https://pubmed.ncbi.nlm.nih.gov/23196134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF230,ENSG00000159882,Unsafe,18823591,"Expression and localization of the spermatogenesis-related gene, Znf230, in mouse testis and spermatozoa during postnatal development.",2008,10.5483/bmbrep.2008.41.9.664,https://pubmed.ncbi.nlm.nih.gov/18823591/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF230,ENSG00000159882,Unsafe,11672448,The shorter zinc finger protein ZNF230 gene message is transcribed in fertile male testes and may be related to human spermatogenesis.,2001,10.1042/0264-6021:3590721,https://pubmed.ncbi.nlm.nih.gov/11672448/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF230,ENSG00000159882,Unsafe,21637524,Molecular cloning and expression analysis of a zebrafish novel zinc finger protein gene rnf141.,2009,10.1590/s1415-47572009005000062,https://pubmed.ncbi.nlm.nih.gov/21637524/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF230,ENSG00000159882,Unsafe,29737531,Specific expression network analysis of diabetic nephropathy kidney tissue revealed key methylated sites.,2018,10.1002/jcp.26638,https://pubmed.ncbi.nlm.nih.gov/29737531/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF230,ENSG00000159882,Unsafe,12804569,Molecular cloning and characterization of a mouse spermatogenesis-related ring finger gene znf230.,2003,10.1016/s0006-291x(03)00970-7,https://pubmed.ncbi.nlm.nih.gov/12804569/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF230,ENSG00000159882,Unsafe,18584306,Spermatogenesis-related ring finger gene ZNF230 promoter: identification and functional analysis.,2009,10.1007/s11033-008-9296-2,https://pubmed.ncbi.nlm.nih.gov/18584306/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF230,ENSG00000159882,Unsafe,15640038,[Construction of recombinant ZNF230/GFP fused plasmids and their expression and cellular localization].,2004,,https://pubmed.ncbi.nlm.nih.gov/15640038/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF230,ENSG00000159882,Unsafe,15952109,Screening for ZNF230 gene mutation and analysis of its correlation with azoospermia.,2005,,https://pubmed.ncbi.nlm.nih.gov/15952109/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF233,ENSG00000159915,Unsafe,42385356,Integrative transcriptomic and CRISPR dependency analysis identifies hepatoblastoma-specific essential genes and actionable vulnerabilities.,2026,10.1016/j.cancergen.2026.06.008,https://pubmed.ncbi.nlm.nih.gov/42385356/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF233,ENSG00000159915,Unsafe,30179682,Knockdown of ZNF233 suppresses hepatocellular carcinoma cell proliferation and tumorigenesis.,2018,10.1016/j.gene.2018.08.070,https://pubmed.ncbi.nlm.nih.gov/30179682/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF257,ENSG00000197134,Unsafe,42360372,Zinc finger protein-associated gene signature serves as a potential predictor for prognosis and therapeutic response in lung adenocarcinoma.,2026,10.1007/s00726-026-03528-y,https://pubmed.ncbi.nlm.nih.gov/42360372/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF257,ENSG00000197134,Unsafe,41488087,Genetic mutations in lymphocytic variant of hypereosinophilic syndrome: study of five siblings.,2025,10.3389/fmed.2025.1679484,https://pubmed.ncbi.nlm.nih.gov/41488087/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF257,ENSG00000197134,Unsafe,40107556,Codon usage bias and nucleotide bias are not influenced by the 5' flanking but by 3' and intronic region composition in SCID-associated genes.,2025,10.1016/j.ijbiomac.2025.142182,https://pubmed.ncbi.nlm.nih.gov/40107556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF257,ENSG00000197134,Unsafe,31871774,Integrative analysis of DNA methylation and gene expression identified cervical cancer-specific diagnostic biomarkers.,2019,10.1038/s41392-019-0081-6,https://pubmed.ncbi.nlm.nih.gov/31871774/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF257,ENSG00000197134,Unsafe,26427027,Functional Impact and Evolution of a Novel Human Polymorphic Inversion That Disrupts a Gene and Creates a Fusion Transcript.,2015,10.1371/journal.pgen.1005495,https://pubmed.ncbi.nlm.nih.gov/26427027/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF257,ENSG00000197134,Unsafe,10585455,Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB.,1999,10.1074/jbc.274.50.35741,https://pubmed.ncbi.nlm.nih.gov/10585455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF264,ENSG00000083844,Unsafe,40367685,The roles of maternal one-carbon metabolism and placental imprinted gene expression in placental development and somatic growth in a longitudinal birth cohort.,2025,10.1016/j.placenta.2025.04.017,https://pubmed.ncbi.nlm.nih.gov/40367685/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF264,ENSG00000083844,Unsafe,39233464,Reciprocal Interactions Between Apelin and Noncoding RNAs in Cancer Progression.,2024,10.1002/cbf.4116,https://pubmed.ncbi.nlm.nih.gov/39233464/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF264,ENSG00000083844,Unsafe,31114952,Circ-ZNF264 Promotes the Growth of Glioma Cells by Upregulating the Expression of miR-4493 Target Gene Apelin.,2019,10.1007/s12031-019-01334-8,https://pubmed.ncbi.nlm.nih.gov/31114952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF264,ENSG00000083844,Unsafe,34631883,"The Role of miRNAs 340-5p, 92a-3p, and 381-3p in Patients with Endometriosis: A Plasma and Mesenchymal Stem-Like Cell Study.",2021,10.1155/2021/5298006,https://pubmed.ncbi.nlm.nih.gov/34631883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF264,ENSG00000083844,Unsafe,36102013,Maternal pre-pregnancy body mass index and offspring with overweight/obesity at preschool age: The possible role of epigenome-wide DNA methylation changes in cord blood.,2023,10.1111/ijpo.12969,https://pubmed.ncbi.nlm.nih.gov/36102013/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF264,ENSG00000083844,Unsafe,36672653,Gene-Function-Based Clusters Explore Intricate Networks of Gene Expression of Circulating Tumor Cells in Patients with Colorectal Cancer.,2023,10.3390/biomedicines11010145,https://pubmed.ncbi.nlm.nih.gov/36672653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF264,ENSG00000083844,Unsafe,34319007,RNA editing affects cis-regulatory elements and predicts adverse cancer survival.,2021,10.1002/cam4.4146,https://pubmed.ncbi.nlm.nih.gov/34319007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF264,ENSG00000083844,Unsafe,31498392,rs11670527 Upstream of ZNF264 Associated with Body Mass Index in the Coriell Personalized Medicine Collaborative.,2020,10.1093/milmed/usz216,https://pubmed.ncbi.nlm.nih.gov/31498392/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF264,ENSG00000083844,Unsafe,11543637,"Imprinting and evolution of two Kruppel-type zinc-finger genes, ZIM3 and ZNF264, located in the PEG3/USP29 imprinted domain.",2001,10.1006/geno.2001.6621,https://pubmed.ncbi.nlm.nih.gov/11543637/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF264,ENSG00000083844,Unsafe,29402175,Imprinting Status in Two Human Parthenogenetic Embryonic Stem Cell Lines: Analysis of 63 Imprinted Gene Expression Levels in Undifferentiated and Early Differentiated Stages.,2018,10.1089/scd.2017.0247,https://pubmed.ncbi.nlm.nih.gov/29402175/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF264,ENSG00000083844,Unsafe,27113098,CPEB4 and IRF4 expression in peripheral mononuclear cells are potential prognostic factors for advanced lung cancer.,2017,10.1016/j.jfma.2016.01.009,https://pubmed.ncbi.nlm.nih.gov/27113098/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF264,ENSG00000083844,Unsafe,21837357,Epigenetic signatures of somatic cell nuclear transfer-derived embryonic stem cells.,2011,10.3892/ijmm.2011.772,https://pubmed.ncbi.nlm.nih.gov/21837357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF264,ENSG00000083844,Unsafe,21827969,Proof of concept study to assess fetal gene expression in amniotic fluid by nanoarray PCR.,2011,10.1016/j.jmoldx.2011.05.008,https://pubmed.ncbi.nlm.nih.gov/21827969/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,42736338,A novel multiomics machine learning signature identifies rapid progression in clinically low risk prostate cancer.,2026,10.1038/s41746-026-03254-5,https://pubmed.ncbi.nlm.nih.gov/42736338/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,37664731,The Expression of ZNF268 and Its Role in The Cisplatin-based Chemoresistance of Breast Cancer.,2023,10.1016/j.heliyon.2023.e18779,https://pubmed.ncbi.nlm.nih.gov/37664731/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,35735115,Noncoding-RNA mediated high expression of zinc finger protein 268 suppresses clear cell renal cell carcinoma progression by promoting apoptosis and regulating immune cell infiltration.,2022,10.1080/21655979.2022.2060787,https://pubmed.ncbi.nlm.nih.gov/35735115/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,34234564,Hsa_circRNA_000543 Predicts Poor Prognosis and Promotes Cervical Cancer Cell Progression Through Regulating miR-567/ZNF268 Axis.,2021,10.2147/cmar.s302201,https://pubmed.ncbi.nlm.nih.gov/34234564/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,37926288,TBK1-stabilized ZNF268a recruits SETD4 to methylate TBK1 for efficient interferon signaling.,2023,10.1016/j.jbc.2023.105428,https://pubmed.ncbi.nlm.nih.gov/37926288/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,34805186,Competitive Endogenous RNA Landscape in Epstein-Barr Virus Associated Nasopharyngeal Carcinoma.,2021,10.3389/fcell.2021.782473,https://pubmed.ncbi.nlm.nih.gov/34805186/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,37270558,"Investigation of enzalutamide, docetaxel, and cabazitaxel resistance in the castration resistant prostate cancer cell line C4 using genome-wide CRISPR/Cas9 screening.",2023,10.1038/s41598-023-35950-7,https://pubmed.ncbi.nlm.nih.gov/37270558/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,31835635,KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly.,2019,10.3390/cells8121604,https://pubmed.ncbi.nlm.nih.gov/31835635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,23091055,The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling.,2012,10.1074/jbc.m112.399923,https://pubmed.ncbi.nlm.nih.gov/23091055/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,23946776,Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells.,2013,10.3892/ol.2013.1318,https://pubmed.ncbi.nlm.nih.gov/23946776/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,24647005,Zinc fingers function cooperatively with KRAB domain for nuclear localization of KRAB-containing zinc finger proteins.,2014,10.1371/journal.pone.0092155,https://pubmed.ncbi.nlm.nih.gov/24647005/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,22235304,"Knockdown of ZNF268, which is transcriptionally downregulated by GATA-1, promotes proliferation of K562 cells.",2012,10.1371/journal.pone.0029518,https://pubmed.ncbi.nlm.nih.gov/22235304/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,33016926,HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus.,2020,10.1172/jci138099,https://pubmed.ncbi.nlm.nih.gov/33016926/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,18949428,Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy.,2008,10.3892/or_00000136,https://pubmed.ncbi.nlm.nih.gov/18949428/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,29456457,Effect of ovarian cancer ascites on SKOV-3 cells proteome: new proteins associated with aggressive phenotype in epithelial ovarian cancer.,2018,10.1186/s12953-018-0133-9,https://pubmed.ncbi.nlm.nih.gov/29456457/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,18375384,Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathway.,2008,10.1074/jbc.m706426200,https://pubmed.ncbi.nlm.nih.gov/18375384/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,16865230,KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains.,2006,10.3892/ijmm.18.3.457,https://pubmed.ncbi.nlm.nih.gov/16865230/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,18774934,The mammalian gene ZNF268 is regulated by hUpf1.,2008,10.1134/s0006297908080051,https://pubmed.ncbi.nlm.nih.gov/18774934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,16735226,[Cloning and characterization of two novel alternatively spliced transcripts of ZNF268].,2006,,https://pubmed.ncbi.nlm.nih.gov/16735226/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,16787922,Transcription of human zinc finger ZNF268 gene requires an intragenic promoter element.,2006,10.1074/jbc.m602753200,https://pubmed.ncbi.nlm.nih.gov/16787922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF268,ENSG00000090612,Unsafe,12200376,Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX.,2002,10.1182/blood-2002-02-0513,https://pubmed.ncbi.nlm.nih.gov/12200376/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF280B,ENSG00000275004,Unsafe,39819193,Effect of extracellular vesicle ZNF280B derived from lung cancer stem cells on lung cancer progression.,2025,10.1080/15384047.2025.2450849,https://pubmed.ncbi.nlm.nih.gov/39819193/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF280B,ENSG00000275004,Unsafe,38003169,Association of SLIT3 and ZNF280B Gene Polymorphisms with Wool Fiber Diameter.,2023,10.3390/ani13223552,https://pubmed.ncbi.nlm.nih.gov/38003169/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF280B,ENSG00000275004,Unsafe,38822135,Novel biomarkers of preterm brain injury from blood transcriptome in sheep model of intrauterine asphyxia.,2024,10.1038/s41390-024-03224-1,https://pubmed.ncbi.nlm.nih.gov/38822135/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF280B,ENSG00000275004,Unsafe,39922874,Characterization of the genomic landscape of canine diffuse large B-cell lymphoma reveals recurrent H3K27M mutations linked to progression-free survival.,2025,10.1038/s41598-025-89245-0,https://pubmed.ncbi.nlm.nih.gov/39922874/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF280B,ENSG00000275004,Unsafe,36978083,Potential miRNA-gene interactions determining progression of various ATLL cancer subtypes after infection by HTLV-1 oncovirus.,2023,10.1186/s12920-023-01492-0,https://pubmed.ncbi.nlm.nih.gov/36978083/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF280B,ENSG00000275004,Unsafe,29556309,ZNF280B promotes the growth of gastric cancer in vitro and in vivo.,2018,10.3892/ol.2018.8060,https://pubmed.ncbi.nlm.nih.gov/29556309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF280B,ENSG00000275004,Unsafe,19027161,Array CGH analysis of chronic lymphocytic leukemia reveals frequent cryptic monoallelic and biallelic deletions of chromosome 22q11 that include the PRAME gene.,2009,10.1016/j.leukres.2008.10.010,https://pubmed.ncbi.nlm.nih.gov/19027161/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF280C,ENSG00000056277,Unsafe,42902322,A lactylation-related transcriptional signature as candidate biomarkers for the early detection of polycystic ovary syndrome: an integrated genomic analysis.,2026,10.1186/s13048-026-02208-5,https://pubmed.ncbi.nlm.nih.gov/42902322/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF280C,ENSG00000056277,Unsafe,35605119,Zinc finger protein 280C contributes to colorectal tumorigenesis by maintaining epigenetic repression at H3K27me3-marked loci.,2022,10.1073/pnas.2120633119,https://pubmed.ncbi.nlm.nih.gov/35605119/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF280C,ENSG00000056277,Unsafe,38412785,Human transcriptome array analysis and diffusion tensor imaging in attention-deficit/hyperactivity disorder.,2024,10.1016/j.jpsychires.2024.02.047,https://pubmed.ncbi.nlm.nih.gov/38412785/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF280C,ENSG00000056277,Unsafe,39834547,An investigation of a hemophilia A female with heterozygous intron 22 inversion and skewed X chromosome inactivation.,2024,10.3389/fgene.2024.1500167,https://pubmed.ncbi.nlm.nih.gov/39834547/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF280C,ENSG00000056277,Unsafe,35323665,Can Exercise Training Alter Human Skeletal Muscle DNA Methylation?,2022,10.3390/metabo12030222,https://pubmed.ncbi.nlm.nih.gov/35323665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF280C,ENSG00000056277,Unsafe,30567999,"Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination.",2019,10.1101/gad.315978.118,https://pubmed.ncbi.nlm.nih.gov/30567999/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF284,ENSG00000186026,Unsafe,40045203,A genome-wide association study identifies a novel East Asian-specific locus for dementia with Lewy bodies in Japanese subjects.,2025,10.1186/s10020-025-01115-7,https://pubmed.ncbi.nlm.nih.gov/40045203/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF284,ENSG00000186026,Unsafe,35769418,A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohorts.,2022,10.1183/23120541.00484-2021,https://pubmed.ncbi.nlm.nih.gov/35769418/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF284,ENSG00000186026,Unsafe,16817023,Cloning and characterization of a novel KRAB-domain-containing zinc finger gene (ZNF284L).,2006,10.1007/s11033-005-6405-3,https://pubmed.ncbi.nlm.nih.gov/16817023/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF284,ENSG00000186026,Unsafe,12743021,Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.,2003,10.1101/gr.963903,https://pubmed.ncbi.nlm.nih.gov/12743021/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF311,ENSG00000197935,Unsafe,40719081,Gene-Smoking Interaction in Insulin Sensitivity and β-Cell Function Among Normal Glucose Tolerance Individuals.,2025,10.1111/1753-0407.70131,https://pubmed.ncbi.nlm.nih.gov/40719081/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF311,ENSG00000197935,Unsafe,39152463,Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta.,2024,10.1186/s13293-024-00629-9,https://pubmed.ncbi.nlm.nih.gov/39152463/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF311,ENSG00000197935,Unsafe,33746099,Prognostic Biomarker ZNF311 and Its Correlation With Tumor Progression and Immune Infiltrates in Glioma.,2021,10.1016/j.wneu.2021.03.064,https://pubmed.ncbi.nlm.nih.gov/33746099/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF311,ENSG00000197935,Unsafe,26019538,Whole genome methylation analyses of schizophrenia patients before and after treatment.,2014,10.1080/13102818.2014.933501,https://pubmed.ncbi.nlm.nih.gov/26019538/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF311,ENSG00000197935,Unsafe,23900074,A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk.,2013,10.1093/hmg/ddt355,https://pubmed.ncbi.nlm.nih.gov/23900074/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF311,ENSG00000197935,Unsafe,28981872,"Telomere length, ATM mutation status and cancer risk in Ataxia-Telangiectasia families.",2017,10.1093/carcin/bgx074,https://pubmed.ncbi.nlm.nih.gov/28981872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF311,ENSG00000197935,Unsafe,24954872,Oligogenic germline mutations identified in early non-smokers lung adenocarcinoma patients.,2014,10.1016/j.lungcan.2014.05.020,https://pubmed.ncbi.nlm.nih.gov/24954872/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF324B,ENSG00000249471,Unsafe,29212247,A six-mRNA signature model for the prognosis of head and neck squamous cell carcinoma.,2017,10.18632/oncotarget.21786,https://pubmed.ncbi.nlm.nih.gov/29212247/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF324B,ENSG00000249471,Unsafe,25852171,Identification of stable reference genes in differentiating human pluripotent stem cells.,2015,10.1152/physiolgenomics.00130.2014,https://pubmed.ncbi.nlm.nih.gov/25852171/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF358,ENSG00000198816,Unsafe,34408667,Genetic and Physiological Effects of Insulin on Human Urate Homeostasis.,2021,10.3389/fphys.2021.713710,https://pubmed.ncbi.nlm.nih.gov/34408667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF358,ENSG00000198816,Unsafe,28161934,Identification of Diverse Adenosine-to-Inosine RNA Editing Subtypes in Colorectal Cancer.,2017,10.4143/crt.2016.301,https://pubmed.ncbi.nlm.nih.gov/28161934/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,41212452,Comprehensive analysis of zinc finger protein 367 as a potential pan-cancer diagnostic and prognostic biomarker and underlying biological mechanisms.,2025,10.1007/s12672-025-03909-x,https://pubmed.ncbi.nlm.nih.gov/41212452/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,41162544,The role of miR-21 in early-stage lung adenocarcinoma: clinical and bioinformatics insights.,2025,10.1038/s41598-025-21742-8,https://pubmed.ncbi.nlm.nih.gov/41162544/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,42357869,"Multi-ancestry genome-wide association meta-analysis of hepatocellular carcinoma identifies 15 risk loci including MAP3K9, DHRS1, MTTP, and 8q24.21.",2026,10.1016/j.xhgg.2026.100639,https://pubmed.ncbi.nlm.nih.gov/42357869/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,39677286,Exploring the Role of SMPD3 in the lncRNA-miRNA-mRNA Regulatory Network in TBI Progression by Influencing Energy Metabolism.,2024,10.2147/jir.s491290,https://pubmed.ncbi.nlm.nih.gov/39677286/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,38880190,Zinc finger protein 367 exerts a cancer-promoting role in small cell lung cancer by influencing the CIT/LATS2/YAP signaling cascade.,2024,10.1016/j.taap.2024.117005,https://pubmed.ncbi.nlm.nih.gov/38880190/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,41129127,Exome and Genome Sequencing Reveals Novel Variants for Severe Diabetic Retinopathy in Type 1 Diabetes.,2025,10.1167/iovs.66.13.36,https://pubmed.ncbi.nlm.nih.gov/41129127/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,42889603,Differential expression of the lncRNA MIR17HG and miR-18a/miR-20a as candidate ncRNA signatures in stage II/III breast cancer and bioinformatic analysis of ncRNA-mRNA regulatory axes.,2026,10.22038/ijbms.2026.95193.20529,https://pubmed.ncbi.nlm.nih.gov/42889603/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,34276213,Long Non-Coding RNA GABPB1-AS1 Augments Malignancy of Glioma Cells by Sequestering MicroRNA-330 and Reinforcing the ZNF367/Cell Cycle Signaling Pathway.,2021,10.2147/ndt.s305182,https://pubmed.ncbi.nlm.nih.gov/34276213/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,35768832,Clinical significance and potential regulatory mechanism of overexpression of pituitary tumor-transforming gene transcription factor in bladder cancer.,2022,10.1186/s12885-022-09810-y,https://pubmed.ncbi.nlm.nih.gov/35768832/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,34319904,TSH/miR-17-5p/ZNF367 axis is related to spontaneous abortion in patients with TSH above 2.5 mIU/L.,2021,10.1530/jme-20-0335,https://pubmed.ncbi.nlm.nih.gov/34319904/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,34351699,Inhibition of zinc finger protein 367 exerts a tumor suppressive role in colorectal cancer by affecting the activation of oncogenic YAP1 signaling.,2021,10.1002/tox.23341,https://pubmed.ncbi.nlm.nih.gov/34351699/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,33770377,Human umbilical cord mesenchymal stem cell-derived exosomes inhibit migration and invasion of breast cancer cells via miR-21-5p/ZNF367 pathway.,2021,10.1007/s12282-021-01218-z,https://pubmed.ncbi.nlm.nih.gov/33770377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,32549756,ZNF367-induced transcriptional activation of KIF15 accelerates the progression of breast cancer.,2020,10.7150/ijbs.44204,https://pubmed.ncbi.nlm.nih.gov/32549756/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,30141410,PAK1 Promotes the Proliferation and Inhibits Apoptosis of Human Spermatogonial Stem Cells via PDK1/KDR/ZNF367 and ERK1/2 and AKT Pathways.,2018,10.1016/j.omtn.2018.06.006,https://pubmed.ncbi.nlm.nih.gov/30141410/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,30087422,The age-regulated zinc finger factor ZNF367 is a new modulator of neuroblast proliferation during embryonic neurogenesis.,2018,10.1038/s41598-018-30302-2,https://pubmed.ncbi.nlm.nih.gov/30087422/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,37185598,"Genes whose expressions in the primary lung squamous cell carcinoma are able to accurately predict the progression of metastasis through lymphatic system, inferred from a bioinformatics analyses.",2023,10.1038/s41598-023-33897-3,https://pubmed.ncbi.nlm.nih.gov/37185598/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,34745933,Prognostic and Predictive Value of Transcription Factors Panel for Digestive System Carcinoma.,2021,10.3389/fonc.2021.670129,https://pubmed.ncbi.nlm.nih.gov/34745933/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,38790973,Modulation of Epithelial-Mesenchymal Transition Is a Possible Underlying Mechanism for Inducing Chemoresistance in MIA PaCa-2 Cells against Gemcitabine and Paclitaxel.,2024,10.3390/biomedicines12051011,https://pubmed.ncbi.nlm.nih.gov/38790973/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,30570867,MiR-24 promotes migration and invasion of non-small cell lung cancer by targeting ZNF367.,2018,,https://pubmed.ncbi.nlm.nih.gov/30570867/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,25047265,ZNF367 inhibits cancer progression and is targeted by miR-195.,2014,10.1371/journal.pone.0101423,https://pubmed.ncbi.nlm.nih.gov/25047265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF367,ENSG00000165244,Unsafe,28036274,Comprehensive tissue-specific gene set enrichment analysis and transcription factor analysis of breast cancer by integrating 14 gene expression datasets.,2017,10.18632/oncotarget.14286,https://pubmed.ncbi.nlm.nih.gov/28036274/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF385D,ENSG00000151789,Unsafe,42603395,Integrated Analysis of SNPs and Structural Variations via High-depth Whole-genome Sequencing Reveals the Genetic Architecture and Optimizes Genomic Prediction in Chickens.,2026,10.1016/j.psj.2026.107561,https://pubmed.ncbi.nlm.nih.gov/42603395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF385D,ENSG00000151789,Unsafe,41102292,Evaluating cell-specific gene expression using single-cell and single-nuclei RNA-sequencing data from human pancreatic islets of the same donors.,2025,10.1038/s41598-025-21595-1,https://pubmed.ncbi.nlm.nih.gov/41102292/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF385D,ENSG00000151789,Unsafe,41655191,"ANXA2, DBN1, ZNF385D, and IL6ST: Endothelial cell biomarkers linking atherosclerosis progression to immune microenvironment dysregulation.",2026,10.1080/10641963.2026.2627352,https://pubmed.ncbi.nlm.nih.gov/41655191/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF385D,ENSG00000151789,Unsafe,40671824,Whole-genome resequencing to investigate the genetic diversity and the molecular basis underlying key economic traits in indigenous sheep breeds adapted to hypoxic environments.,2025,10.3389/fvets.2025.1605252,https://pubmed.ncbi.nlm.nih.gov/40671824/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF385D,ENSG00000151789,Unsafe,38397203,Transcription Factor Regulation of Gene Expression Network by ZNF385D and HAND2 in Carotid Atherosclerosis.,2024,10.3390/genes15020213,https://pubmed.ncbi.nlm.nih.gov/38397203/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF385D,ENSG00000151789,Unsafe,39674387,Genetics of constant and severe pain in the NAPS2 cohort of recurrent acute and chronic pancreatitis patients.,2025,10.1016/j.jpain.2024.104754,https://pubmed.ncbi.nlm.nih.gov/39674387/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF385D,ENSG00000151789,Unsafe,37127706,Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles.,2023,10.1186/s13073-023-01179-2,https://pubmed.ncbi.nlm.nih.gov/37127706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF385D,ENSG00000151789,Unsafe,31322274,Low lncRNA ZNF385D‑AS2 expression and its prognostic significance in liver cancer.,2019,10.3892/or.2019.7238,https://pubmed.ncbi.nlm.nih.gov/31322274/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF385D,ENSG00000151789,Unsafe,36675818,Exploring Genetic and Neural Risk of Specific Reading Disability within a Nuclear Twin Family Case Study: A Translational Clinical Application.,2023,10.3390/jpm13010156,https://pubmed.ncbi.nlm.nih.gov/36675818/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF385D,ENSG00000151789,Unsafe,35135230,Elevated expression of the MYB proto-oncogene like 2 (MYBL2)-encoding gene as a prognostic and predictive biomarker in human cancers.,2022,10.3934/mbe.2022085,https://pubmed.ncbi.nlm.nih.gov/35135230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF385D,ENSG00000151789,Unsafe,34852643,Twenty-Five Novel Loci for Carotid Intima-Media Thickness: A Genome-Wide Association Study in &gt;45 000 Individuals and Meta-Analysis of &gt;100 000 Individuals.,2022,10.1161/atvbaha.121.317007,https://pubmed.ncbi.nlm.nih.gov/34852643/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF385D,ENSG00000151789,Unsafe,24024963,Genome-wide association study of shared components of reading disability and language impairment.,2013,10.1111/gbb.12085,https://pubmed.ncbi.nlm.nih.gov/24024963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF385D,ENSG00000151789,Unsafe,28696415,Genome-wide association studies of placebo and duloxetine response in major depressive disorder.,2018,10.1038/tpj.2017.29,https://pubmed.ncbi.nlm.nih.gov/28696415/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF385D,ENSG00000151789,Unsafe,30567476,HisCoM-GGI: Hierarchical structural component analysis of gene-gene interactions.,2018,10.1142/s0219720018400267,https://pubmed.ncbi.nlm.nih.gov/30567476/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF385D,ENSG00000151789,Unsafe,23382809,BCL9 and C9orf5 are associated with negative symptoms in schizophrenia: meta-analysis of two genome-wide association studies.,2013,10.1371/journal.pone.0051674,https://pubmed.ncbi.nlm.nih.gov/23382809/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF385D,ENSG00000151789,Unsafe,24387768,Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1.,2014,10.1186/1471-2350-15-2,https://pubmed.ncbi.nlm.nih.gov/24387768/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF385D,ENSG00000151789,Unsafe,17846125,A search for variants associated with young-onset type 2 diabetes in American Indians in a 100K genotyping array.,2007,10.2337/db07-0462,https://pubmed.ncbi.nlm.nih.gov/17846125/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF391,ENSG00000124613,Unsafe,42845231,Genome-Wide Risk Assessment and Clinical Prediction of Iodinated Contrast Media-Induced Anaphylaxis.,2026,10.4168/aair.2026.18.5.776,https://pubmed.ncbi.nlm.nih.gov/42845231/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF391,ENSG00000124613,Unsafe,33822213,"Spatial Expression Pattern of ZNF391 Gene in the Brains of Patients With Schizophrenia, Bipolar Disorders or Major Depressive Disorder Identifies New Cross-Disorder Biotypes: A Trans-Diagnostic, Top-Down Approach.",2021,10.1093/schbul/sbaa167,https://pubmed.ncbi.nlm.nih.gov/33822213/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF391,ENSG00000124613,Unsafe,35971078,"Genome-wide association study identifying genetic variants associated with carcass backfat thickness, lean percentage and fat percentage in a four-way crossbred pig population using SLAF-seq technology.",2022,10.1186/s12864-022-08827-8,https://pubmed.ncbi.nlm.nih.gov/35971078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF391,ENSG00000124613,Unsafe,32685390,Identification of differentially expressed metastatic genes and their signatures to predict the overall survival of uveal melanoma patients by bioinformatics analysis.,2020,10.18240/ijo.2020.07.05,https://pubmed.ncbi.nlm.nih.gov/32685390/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,41637546,ZNF395 Is a Hypoxia-Responsive Regulator of Mitochondrial Glutaminolysis in Clear Cell Renal Cell Carcinoma.,2026,10.1158/0008-5472.can-24-4745,https://pubmed.ncbi.nlm.nih.gov/41637546/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,41165207,lncDILC Downregulation in Liver Cancer-Associated Fibroblasts Drives Pro-Invasive Conversion via a miR-6071-ZNF395 Axis.,2026,10.1111/cas.70236,https://pubmed.ncbi.nlm.nih.gov/41165207/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,41641434,Integrative Meta-Analysis and WGCNA Reveal Candidate Diagnostic Hub Genes in Clear Cell Carcinoma.,2026,10.1155/ijcb/5567255,https://pubmed.ncbi.nlm.nih.gov/41641434/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,42701775,Bioinformatics Screening and Preliminary Experimental Verification of Integrated Stress Response-Associated MYC and BAG3 in Chronic Obstructive Pulmonary Disease.,2026,10.2147/copd.s615813,https://pubmed.ncbi.nlm.nih.gov/42701775/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,42196408,Integrative Transcriptomic Analysis Identifies Shared Immune-Fibrotic Transcriptional Programs Across Crohn's Disease and Idiopathic Pulmonary Fibrosis.,2026,10.3390/ijms27104428,https://pubmed.ncbi.nlm.nih.gov/42196408/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,39348078,"Upregulation of Apoptosis Related Genes in Clinically Normal Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Effort to Maintain Tissue Homeostasis.",2024,10.1007/s12105-024-01695-6,https://pubmed.ncbi.nlm.nih.gov/39348078/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,39724092,Human cytomegalovirus RNA2.7 inhibits ferroptosis by upregulating ferritin and GSH via promoting ZNF395 degradation.,2024,10.1371/journal.ppat.1012815,https://pubmed.ncbi.nlm.nih.gov/39724092/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,37970347,Preclinical trial of targeting the Hic-5-mediated pathway to prevent the progression of hepatocellular carcinoma.,2023,,https://pubmed.ncbi.nlm.nih.gov/37970347/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,36225626,ZNF395 facilitates macrophage polarization and impacts the prognosis of glioma.,2022,,https://pubmed.ncbi.nlm.nih.gov/36225626/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,40578157,Allele-specific expression in non-small cell lung cancer: A genome-wide investigation.,2025,10.1016/j.compbiomed.2025.110582,https://pubmed.ncbi.nlm.nih.gov/40578157/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,34113121,Dysregulation of Zinc Finger Protein 395 Contributes to the Pathogenesis of Chondrosarcoma.,2021,10.2147/ott.s310164,https://pubmed.ncbi.nlm.nih.gov/34113121/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,33794543,Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential.,2021,10.1159/000514593,https://pubmed.ncbi.nlm.nih.gov/33794543/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,32560659,HnRNP A1 - mediated alternative splicing of CCDC50 contributes to cancer progression of clear cell renal cell carcinoma via ZNF395.,2020,10.1186/s13046-020-01606-x,https://pubmed.ncbi.nlm.nih.gov/32560659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,34345851,The low doses of SWCNTs affect the expression of proliferation and apoptosis related genes in normal human astrocytes.,2021,10.1016/j.crtox.2021.02.001,https://pubmed.ncbi.nlm.nih.gov/34345851/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,27980417,"Clinicopathological Significance of TARBP2, APP, and ZNF395 in Breast Cancer.",2016,10.4137/bcbcr.s40820,https://pubmed.ncbi.nlm.nih.gov/27980417/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,28316371,ZNF395 Is an Activator of a Subset of IFN-Stimulated Genes.,2017,10.1155/2017/1248201,https://pubmed.ncbi.nlm.nih.gov/28316371/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,36557693,Comparative Analysis of the Liver Transcriptome of Beijing You Chickens and Guang Ming Broilers under Salmonella enterica Serovar Typhimurium Infection.,2022,10.3390/microorganisms10122440,https://pubmed.ncbi.nlm.nih.gov/36557693/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,30890014,"Sheep zinc finger proteins 395 (ZNF395): insertion/deletion variations, associations with growth traits, and mRNA expression.",2020,10.1080/10495398.2019.1585865,https://pubmed.ncbi.nlm.nih.gov/30890014/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,26229239,The Transcription Factor ZNF395 Is Required for the Maximal Hypoxic Induction of Proinflammatory Cytokines in U87-MG Cells.,2015,10.1155/2015/804264,https://pubmed.ncbi.nlm.nih.gov/26229239/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,34926439,Integrated Study of Transcriptome-wide m6A Methylome Reveals Novel Insights Into the Character and Function of m6A Methylation During Yak Adipocyte Differentiation.,2021,10.3389/fcell.2021.689067,https://pubmed.ncbi.nlm.nih.gov/34926439/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,24086395,The hypoxia-inducible transcription factor ZNF395 is controlled by IĸB kinase-signaling and activates genes involved in the innate immune response and cancer.,2013,10.1371/journal.pone.0074911,https://pubmed.ncbi.nlm.nih.gov/24086395/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,30665429,An integrative genomic analysis of transcriptional profiles identifies characteristic genes and patterns in HIV-infected long-term non-progressors and elite controllers.,2019,10.1186/s12967-019-1777-7,https://pubmed.ncbi.nlm.nih.gov/30665429/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,17897615,Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex.,2007,10.1016/j.abb.2007.08.015,https://pubmed.ncbi.nlm.nih.gov/17897615/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,19536297,Modulation of angiogenic and inflammatory response in glioblastoma by hypoxia.,2009,10.1371/journal.pone.0005947,https://pubmed.ncbi.nlm.nih.gov/19536297/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,14625278,"Novel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal cell-specific cis-regulatory element in the promoter for the human Huntington's disease gene.",2004,10.1074/jbc.m310726200,https://pubmed.ncbi.nlm.nih.gov/14625278/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF395,ENSG00000186918,Unsafe,11853404,A new cellular factor recognizes E2 binding sites of papillomaviruses which mediate transcriptional repression by E2.,2002,10.1006/viro.2001.1231,https://pubmed.ncbi.nlm.nih.gov/11853404/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF397,ENSG00000186812,Unsafe,42754162,Dynamic reprogramming and A-to-I RNA editing in neutrophils in response to tumor induction.,2026,10.1016/j.jbc.2026.113569,https://pubmed.ncbi.nlm.nih.gov/42754162/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF397,ENSG00000186812,Unsafe,38591846,ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer.,2024,10.1158/2159-8290.cd-23-0539,https://pubmed.ncbi.nlm.nih.gov/38591846/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF397,ENSG00000186812,Unsafe,34002480,"Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants.",2021,10.1002/alz.12333,https://pubmed.ncbi.nlm.nih.gov/34002480/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF397,ENSG00000186812,Unsafe,30820981,Comparative proteomic analysis of high- and low-fertile buffalo bull spermatozoa for identification of fertility-associated proteins.,2019,10.1111/rda.13426,https://pubmed.ncbi.nlm.nih.gov/30820981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF397,ENSG00000186812,Unsafe,18369653,"ZNF397, a new class of interphase to early prophase-specific, SCAN-zinc-finger, mammalian centromere protein.",2008,10.1007/s00412-008-0155-7,https://pubmed.ncbi.nlm.nih.gov/18369653/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF397,ENSG00000186812,Unsafe,12801647,Identification and characterization of two novel human SCAN domain-containing zinc finger genes ZNF396 and ZNF397.,2003,10.1016/s0378-1119(03)00551-1,https://pubmed.ncbi.nlm.nih.gov/12801647/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF397,ENSG00000186812,Unsafe,17451405,Mapping of a gene for alopecia with mental retardation syndrome (APMR3) on chromosome 18q11.2-q12.2.,2007,10.1111/j.1469-1809.2007.00362.x,https://pubmed.ncbi.nlm.nih.gov/17451405/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF407,ENSG00000215421,Unsafe,41903465,Metabolite-based genome-wide association analysis reveals genetic loci and candidate genes affecting breast muscle metabolites in Sansui ducks.,2026,10.1016/j.psj.2026.106817,https://pubmed.ncbi.nlm.nih.gov/41903465/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF407,ENSG00000215421,Unsafe,41154723,Pan-Cancer Analysis of Mutations Affecting Protein Liquid-Liquid Phase Separation Revealing Clinical Implications.,2025,10.3390/biology14101320,https://pubmed.ncbi.nlm.nih.gov/41154723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF407,ENSG00000215421,Unsafe,36076300,Construction of the coexpression network involved in the pathogenesis of thyroid eye disease via bioinformatics analysis.,2022,10.1186/s40246-022-00412-0,https://pubmed.ncbi.nlm.nih.gov/36076300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF407,ENSG00000215421,Unsafe,24907849,Mutations in zinc finger 407 [ZNF407] cause a unique autosomal recessive cognitive impairment syndrome.,2014,10.1186/1750-1172-9-80,https://pubmed.ncbi.nlm.nih.gov/24907849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF407,ENSG00000215421,Unsafe,29523860,Allele-specific expression in a family quartet with autism reveals mono-to-biallelic switch and novel transcriptional processes of autism susceptibility genes.,2018,10.1038/s41598-018-22753-4,https://pubmed.ncbi.nlm.nih.gov/29523860/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF407,ENSG00000215421,Unsafe,36011330,Genetic Parameters and Genomic Regions Underlying Growth and Linear Type Traits in Akkaraman Sheep.,2022,10.3390/genes13081414,https://pubmed.ncbi.nlm.nih.gov/36011330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF407,ENSG00000215421,Unsafe,28300833,PI3K/AKT-mediated upregulation of WDR5 promotes colorectal cancer metastasis by directly targeting ZNF407.,2017,10.1038/cddis.2017.111,https://pubmed.ncbi.nlm.nih.gov/28300833/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF407,ENSG00000215421,Unsafe,37390921,Evaluating the interaction between 3'aQTL and alcohol consumption/smoking on anxiety and depression: 3'aQTL-by-environment interaction study in UK Biobank cohort.,2023,10.1016/j.jad.2023.06.050,https://pubmed.ncbi.nlm.nih.gov/37390921/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF407,ENSG00000215421,Unsafe,26102504,KIT Mutation and Loss of 14q May Be Sufficient for the Development of Clinically Symptomatic Very Low-Risk GIST.,2015,10.1371/journal.pone.0130149,https://pubmed.ncbi.nlm.nih.gov/26102504/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF407,ENSG00000215421,Unsafe,23195952,Balanced translocation t(3;18)(p13;q22.3) and points mutation in the ZNF407 gene detected in patients with both moderate non-syndromic intellectual disability and autism.,2013,10.1016/j.bbadis.2012.11.009,https://pubmed.ncbi.nlm.nih.gov/23195952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF407,ENSG00000215421,Unsafe,29330500,"Integration of GWAS, pathway and network analyses reveals novel mechanistic insights into the synthesis of milk proteins in dairy cows.",2018,10.1038/s41598-017-18916-4,https://pubmed.ncbi.nlm.nih.gov/29330500/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF407,ENSG00000215421,Unsafe,24092497,Establishing a reference group for distal 18q-: clinical description and molecular basis.,2014,10.1007/s00439-013-1364-6,https://pubmed.ncbi.nlm.nih.gov/24092497/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,42391152,The Effect on Vitamin D Levels and VDR Gene Polymorphism on Clinical Outcomes in Asthma.,2026,10.1159/000553361,https://pubmed.ncbi.nlm.nih.gov/42391152/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,42829446,Cooperation between Adh and OR5M11 contributes to the lung pathogenicity of Actinobacillus pleuropneumoniae by facilitating the NLRP3-mediated inflammatory response.,2026,10.1186/s13567-026-01845-4,https://pubmed.ncbi.nlm.nih.gov/42829446/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,42785298,Systemic delivery of phagocytosis-shielded retroviral vectors enables in vivo HSC gene therapy for sickle cell disease.,2026,10.1016/j.stem.2026.09.001,https://pubmed.ncbi.nlm.nih.gov/42785298/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,42893018,Characterization of two Mutator insertion alleles of &lt;i&gt;Chr101&lt;/i&gt; during maize vegetative development.,2026,10.17912/micropub.biology.002431,https://pubmed.ncbi.nlm.nih.gov/42893018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,40158221,SWI/SNF complex-mediated ZNF410 cooperative binding maintains chromatin accessibility and enhancer activity.,2025,10.1016/j.celrep.2025.115476,https://pubmed.ncbi.nlm.nih.gov/40158221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,39062692,Exploring the Influence of Fok1/Apa1 Polymorphic Variants on Adolescent Mental Health and Response to Vitamin D Supplementation in Embryonic Hippocampal Cell Lines.,2024,10.3390/genes15070913,https://pubmed.ncbi.nlm.nih.gov/39062692/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,42555666,Motif-Cluster: Motif driven prioritization of transcription factor binding clusters.,2026,10.1371/journal.pcbi.1014639,https://pubmed.ncbi.nlm.nih.gov/42555666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,40390930,&lt;i&gt;FOK1&lt;/i&gt; and &lt;i&gt;APA1&lt;/i&gt; Gene Polymorphism Among Polycystic Ovary Syndrome: A Prospective Cohort Study.,2025,10.1007/s13224-024-02024-1,https://pubmed.ncbi.nlm.nih.gov/40390930/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,40467945,Combined methods of mutation breeding and genetice modifications enhanced rhamnolipids production of oil well Indigenous Pseusdomonas aeruginosa.,2025,10.1038/s41598-025-04671-4,https://pubmed.ncbi.nlm.nih.gov/40467945/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,41994064,Association of Vitamin D Receptor Gene Polymorphisms with Periodontitis.,2026,10.30476/dentjods.2025.103866.2485,https://pubmed.ncbi.nlm.nih.gov/41994064/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,38440355,The Relationship between &lt;i&gt;VDR&lt;/i&gt; Gene Polymorphisms &lt;i&gt;Bsm1&lt;/i&gt; and &lt;i&gt;Apa1&lt;/i&gt; with Breast Cancer Risk.,2024,10.1055/s-0044-1779040,https://pubmed.ncbi.nlm.nih.gov/38440355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,41560560,"Genomic characterization of &lt;i&gt;Actinobacillus pleuropneumoniae&lt;/i&gt; serovars 5, 8, and 15 strains from diseased pigs in eastern Chinese provinces.",2026,10.1080/21505594.2026.2620200,https://pubmed.ncbi.nlm.nih.gov/41560560/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,36660822,Allosteric autoregulation of DNA binding via a DNA-mimicking protein domain: a biophysical study of ZNF410-DNA interaction using small angle X-ray scattering.,2023,10.1093/nar/gkac1274,https://pubmed.ncbi.nlm.nih.gov/36660822/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,38988326,Exploring the role of anticipatory postural adjustment duration within APA2 subphase as a potential mediator between clinical disease severity and fall risk in Parkinson's disease.,2024,10.3389/fnagi.2024.1354387,https://pubmed.ncbi.nlm.nih.gov/38988326/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,42256383,A Kinematic Analysis of Automatic Postural Responses during Predicted and Unpredicted Postural Perturbations in People with Low Back Pain.,2026,10.22038/abjs.2025.87584.3968,https://pubmed.ncbi.nlm.nih.gov/42256383/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,41824933,A Lack of Association between Vitamin D Receptor Gene Polymorphisms with Colorectal Cancer: A Comprehensive Meta-Analysis and Power Assessment.,2026,10.1615/critreveukaryotgeneexpr.2025062255,https://pubmed.ncbi.nlm.nih.gov/41824933/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,41731357,"Whole genome sequencing analyses of Chinese Glaesserella parasuis isolates reveal insights into their genomic characterization, virulence genes and antibiotic resistance genes.",2026,10.1186/s12864-026-12636-8,https://pubmed.ncbi.nlm.nih.gov/41731357/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,38745893,"A novel high-titer, bifunctional lentiviral vector for autologous hematopoietic stem cell gene therapy of sickle cell disease.",2024,10.1016/j.omtm.2024.101254,https://pubmed.ncbi.nlm.nih.gov/38745893/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,38721008,ApaI and Fok1 Variants of Vitamin D Receptor Gene Associated with Metabolic Syndrome Among Jordanian Women.,2024,10.5001/omj.2024.47,https://pubmed.ncbi.nlm.nih.gov/38721008/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,33859416,ZNF410 represses fetal globin by singular control of CHD4.,2021,10.1038/s41588-021-00843-w,https://pubmed.ncbi.nlm.nih.gov/33859416/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,37298481,Precision Editing as a Therapeutic Approach for β-Hemoglobinopathies.,2023,10.3390/ijms24119527,https://pubmed.ncbi.nlm.nih.gov/37298481/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,38223006,"An Updated Trial Sequential Meta-analysis of Vitamin D Receptor Gene Polymorphism (Fok1, Bsm1, Taq1 and Apa1) and Risk to Tuberculosis.",2024,10.1007/s12291-022-01091-3,https://pubmed.ncbi.nlm.nih.gov/38223006/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,38230232,Gait initiation in Parkinson's disease: comparison of timing and displacement during anticipatory postural adjustments as a function of motor severity and apathy in a large cohort.,2024,10.1016/j.heliyon.2023.e23740,https://pubmed.ncbi.nlm.nih.gov/38230232/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,38982892,The effects of combining sensorimotor training with transcranial direct current stimulation on the anticipatory and compensatory postural adjustments in patients with chronic low back pain.,2025,10.1080/09638288.2024.2375756,https://pubmed.ncbi.nlm.nih.gov/38982892/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,36741989,A meta-analysis suggests the association of reduced serum level of vitamin D and T-allele of Fok1 (rs2228570) polymorphism in the vitamin D receptor gene with celiac disease.,2022,10.3389/fnut.2022.996450,https://pubmed.ncbi.nlm.nih.gov/36741989/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,32939414,Association of vitamin D gene polymorphisms in children with asthma - A systematic review.,2020,10.1016/j.heliyon.2020.e04795,https://pubmed.ncbi.nlm.nih.gov/32939414/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,35656282,"Frequency of Genotypes and Allelic Polymorphisms of Vitamin D Receptor in Egyptian Psoriatic Patients and Their Association With Disease Severity, Immune Modulation of IL-22 Levels and The Response to Topical Calcipotriol Treatment: A Case Control Study.",2022,10.4103/ijd.ijd_799_21,https://pubmed.ncbi.nlm.nih.gov/35656282/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,31534663,Study of Vitamin D Level and Vitamin D Receptor Polymorphism in Hypothyroid Egyptian Patients.,2019,10.1155/2019/3583250,https://pubmed.ncbi.nlm.nih.gov/31534663/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,33969140,Genotype Distribution of Vitamin D Receptor Polymorphisms among Indonesian Patients with Chronic Hepatitis B.,2021,10.52547/rbmb.9.4.463,https://pubmed.ncbi.nlm.nih.gov/33969140/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,33621190,Improving the Understanding of the Immunopathogenesis of Lymphopenia as a Correlate of SARS-CoV-2 Infection Risk and Disease Progression in African Patients: Protocol for a Cross-sectional Study.,2021,10.2196/21242,https://pubmed.ncbi.nlm.nih.gov/33621190/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,27152640,Anticipatory and Compensatory Postural Adjustments in Response to External Lateral Shoulder Perturbations in Subjects with Parkinson's Disease.,2016,10.1371/journal.pone.0155012,https://pubmed.ncbi.nlm.nih.gov/27152640/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,23418495,"1,25-dihydroxyvitamin D and the vitamin D receptor gene polymorphism Apa1 influence bone mineral density in primary hyperparathyroidism.",2013,10.1371/journal.pone.0056019,https://pubmed.ncbi.nlm.nih.gov/23418495/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,15790785,Ligand-induced conformational change in the T-cell receptor associated with productive immune synapses.,2005,10.1182/blood-2004-12-4763,https://pubmed.ncbi.nlm.nih.gov/15790785/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF410,ENSG00000119725,Unsafe,12370286,Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1.,2002,10.1128/mcb.22.21.7385-7397.2002,https://pubmed.ncbi.nlm.nih.gov/12370286/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF416,ENSG00000083817,Unsafe,40176795,Mechanism of action and experimental validation of key genes common to diabetic retinopathy and coronary heart disease based on multiple bioinformatics investigations.,2025,10.3389/fgene.2025.1548147,https://pubmed.ncbi.nlm.nih.gov/40176795/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF416,ENSG00000083817,Unsafe,36371191,Targeted delivery of ZNF416 siRNA-loaded liposomes attenuates experimental pulmonary fibrosis.,2022,10.1186/s12967-022-03740-w,https://pubmed.ncbi.nlm.nih.gov/36371191/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF416,ENSG00000083817,Unsafe,38284107,Explore the role of long noncoding RNAs and mRNAs in intracranial atherosclerotic stenosis: From the perspective of neutrophils.,2023,10.4103/bc.bc_63_23,https://pubmed.ncbi.nlm.nih.gov/38284107/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF416,ENSG00000083817,Unsafe,33625469,ZNF416 is a pivotal transcriptional regulator of fibroblast mechanoactivation.,2021,10.1083/jcb.202007152,https://pubmed.ncbi.nlm.nih.gov/33625469/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF416,ENSG00000083817,Unsafe,33059369,DeepHPV: a deep learning model to predict human papillomavirus integration sites.,2021,10.1093/bib/bbaa242,https://pubmed.ncbi.nlm.nih.gov/33059369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF425,ENSG00000204947,Unsafe,34227876,Evaluation of Reliable Reference Genes for In Vitro Erythrocyte Generation from Cord Blood CD34+ Cells.,2021,10.1089/dna.2021.0185,https://pubmed.ncbi.nlm.nih.gov/34227876/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF425,ENSG00000204947,Unsafe,33426398,Comprehensive Review of Steroid-Sensitive Nephrotic Syndrome Genetic Risk Loci and Transcriptional Regulation as a Possible Mechanistic Link to Disease Risk.,2021,10.1016/j.ekir.2020.09.048,https://pubmed.ncbi.nlm.nih.gov/33426398/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF425,ENSG00000204947,Unsafe,21266108,A novel human KRAB-related zinc finger gene ZNF425 inhibits mitogen-activated protein kinase signaling pathway.,2011,10.5483/bmbrep.2011.44.1.58,https://pubmed.ncbi.nlm.nih.gov/21266108/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF43,ENSG00000198521,Unsafe,36142151,Significance of Hypermethylation of Tumor-Suppressor Genes PTGER4 and ZNF43 at CpG Sites in the Prognosis of Colorectal Cancer.,2022,10.3390/ijms231810225,https://pubmed.ncbi.nlm.nih.gov/36142151/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF43,ENSG00000198521,Unsafe,38287071,Prognostic DNA mutation and mRNA expression analysis of perineural invasion in oral squamous cell carcinoma.,2024,10.1038/s41598-024-52745-6,https://pubmed.ncbi.nlm.nih.gov/38287071/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF43,ENSG00000198521,Unsafe,35794182,Prognostic and therapeutic prediction by screening signature combinations from transcriptome-methylome interactions in oral squamous cell carcinoma.,2022,10.1038/s41598-022-15534-7,https://pubmed.ncbi.nlm.nih.gov/35794182/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF43,ENSG00000198521,Unsafe,38082666,Identification of Mild Cognitive Impairment Subtypes using an Interpretable Neural Network based Clustering of Gene Expression Data and Neuroimaging Markers.,2023,10.1109/embc40787.2023.10340584,https://pubmed.ncbi.nlm.nih.gov/38082666/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF43,ENSG00000198521,Unsafe,31719764,Functional association between NUCKS1 gene and Parkinson disease: A potential susceptibility biomarker.,2019,10.6026/97320630015548,https://pubmed.ncbi.nlm.nih.gov/31719764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF43,ENSG00000198521,Unsafe,30999858,Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer.,2019,10.1186/s12859-019-2687-7,https://pubmed.ncbi.nlm.nih.gov/30999858/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF43,ENSG00000198521,Unsafe,22701369,Correlation of dynamic PET and gene array data in patients with gastrointestinal stromal tumors.,2012,10.1100/2012/721313,https://pubmed.ncbi.nlm.nih.gov/22701369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF43,ENSG00000198521,Unsafe,19742314,ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines.,2009,10.1371/journal.pone.0006967,https://pubmed.ncbi.nlm.nih.gov/19742314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF43,ENSG00000198521,Unsafe,12537770,Expression and regulation of the transcriptional repressor ZNF43 in Ewing sarcoma cells.,2002,10.1080/15227950290112789,https://pubmed.ncbi.nlm.nih.gov/12537770/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF43,ENSG00000198521,Unsafe,1711675,A gene encoding 22 highly related zinc fingers is expressed in lymphoid cell lines.,1991,10.1093/nar/19.11.2921,https://pubmed.ncbi.nlm.nih.gov/1711675/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF430,ENSG00000118620,Unsafe,41491226,Νovel methylation biomarkers in liquid biopsy and classifying biosignatures for the clinical management of breast cancer.,2026,10.1186/s13058-025-02170-y,https://pubmed.ncbi.nlm.nih.gov/41491226/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF430,ENSG00000118620,Unsafe,37217947,THE1B may have no role in human pregnancy due to ZNF430-mediated silencing.,2023,10.1186/s13100-023-00294-6,https://pubmed.ncbi.nlm.nih.gov/37217947/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF430,ENSG00000118620,Unsafe,38131004,The successive emergence of ERVL-MaLRs in primates.,2023,10.1093/ve/vead072,https://pubmed.ncbi.nlm.nih.gov/38131004/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,41969486,ZNF460 inhibits HMGCL and promotes PI3K pathway in colon cancer.,2026,10.21037/tcr-2025-aw-2410,https://pubmed.ncbi.nlm.nih.gov/41969486/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,41923736,&lt;i&gt;ZNF460&lt;/i&gt; Promotes &lt;i&gt;GSDME&lt;/i&gt;-Driven Pyroptosis via &lt;i&gt;PKM2&lt;/i&gt; Transcriptional Activation in Aortic Dissection.,2026,10.31083/rcm48463,https://pubmed.ncbi.nlm.nih.gov/41923736/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,41927792,M&lt;sup&gt;6&lt;/sup&gt;A-dependent upregulation of ZNF460 promotes epithelial-mesenchymal transition and metastasis of gastric cancer through a histone modification-mediated positive feedback loop.,2026,10.1038/s41388-026-03755-3,https://pubmed.ncbi.nlm.nih.gov/41927792/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,41931991,Chrysophanol exerts neuroprotection against cerebral ischemia- reperfusion injury by regulating IκBα-stabilized MLKL via ZNF460-TRAF6 axis.,2026,10.1016/j.phymed.2026.158104,https://pubmed.ncbi.nlm.nih.gov/41931991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,41806184,ZNF460 Promotes the m6A Modification of COPS6 to Facilitate Immune Escape in Colorectal Cancer.,2026,10.1096/fj.202503485r,https://pubmed.ncbi.nlm.nih.gov/41806184/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,41782876,CircNF1 promotes gastric cancer metastasis by stabilizing HMGA2 mRNA through IGF2BP1 interaction.,2026,10.3389/fimmu.2026.1767319,https://pubmed.ncbi.nlm.nih.gov/41782876/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,40591048,KMT2D/ZNF460-induced COL9A1-mediated extracellular matrix stiffness maintains the cancer stem cell pool to promote colorectal cancer progression.,2025,10.1007/s10565-025-10053-3,https://pubmed.ncbi.nlm.nih.gov/40591048/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,41164196,Cytoplasmic HMGB1 promotes and interacts with BECN1 through ZNF460 to induce autophagy and accelerate radioresistance in colorectal cancer cells.,2025,10.3389/fimmu.2025.1642915,https://pubmed.ncbi.nlm.nih.gov/41164196/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,40521987,LncRNA SNHG14 Regulated by ZNF460 Promotes Gastric Cancer Progression and Metastasis by Targeting the miR-206/FNDC3A Axis.,2025,10.1111/jcmm.70652,https://pubmed.ncbi.nlm.nih.gov/40521987/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,40723891,Targeting Sodium Transport Reveals CHP1 Downregulation as a Novel Molecular Feature of Malignant Progression in Clear Cell Renal Cell Carcinoma: Insights from Integrated Multi-Omics Analyses.,2025,10.3390/biom15071019,https://pubmed.ncbi.nlm.nih.gov/40723891/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,40404004,ZNF460 enhances HADHB level by activating its transcription to promote the progression and pulmonary invasion of cutaneous T cell lymphoma.,2025,10.1016/j.abb.2025.110472,https://pubmed.ncbi.nlm.nih.gov/40404004/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,39779708,Stereo-seq of the prefrontal cortex in aging and Alzheimer's disease.,2025,10.1038/s41467-024-54715-y,https://pubmed.ncbi.nlm.nih.gov/39779708/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,38914670,LINC00525 enhances ZNF460-regulated CD24 expression through the sponge miR-125a-5p to promote malignant progression of breast cancer.,2024,10.1007/s00432-024-05830-2,https://pubmed.ncbi.nlm.nih.gov/38914670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,42742217,The E3 ubiquitin ligase IDOL suppresses PRRSV replication by targeting viral Nsp3 for SQSTM1-mediated selective autophagic degradation.,2026,10.1128/mbio.01534-26,https://pubmed.ncbi.nlm.nih.gov/42742217/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,37057209,ZNF460-regulated COMMD7 Promotes Acute Myeloid Leukemia Proliferation Via the NF-κB Signaling Pathway.,2023,10.7150/ijms.80047,https://pubmed.ncbi.nlm.nih.gov/37057209/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,38355583,ZNF460-mediated circRPPH1 promotes TNBC progression through ITGA5-induced FAK/PI3K/AKT activation in a ceRNA manner.,2024,10.1186/s12943-024-01944-w,https://pubmed.ncbi.nlm.nih.gov/38355583/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,40967941,"High MRPL12 expression drives esophageal cancer proliferation, invasion and migration.",2025,10.1016/j.bulcan.2025.07.012,https://pubmed.ncbi.nlm.nih.gov/40967941/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,36563923,ZNF460 mediates epithelial-mesenchymal transition to promote gastric cancer progression by transactivating APOC1 expression.,2023,10.1016/j.yexcr.2022.113452,https://pubmed.ncbi.nlm.nih.gov/36563923/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,39210030,ZNF460-mediated upregulation of APCDD1L-DT promotes cholangiocarcinoma development by inhibiting the ubiquitin-mediated degradation of DVL2.,2024,10.1038/s41417-024-00826-z,https://pubmed.ncbi.nlm.nih.gov/39210030/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,41091903,ITLN1 Improves Endothelial Dysfunction in Hypertensive Mice via Wnt5b-JNK Signaling.,2025,10.1161/hypertensionaha.125.25275,https://pubmed.ncbi.nlm.nih.gov/41091903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,42177885,Modified Fuzheng Yiliu Decoction chemosensitizes colorectal cancer by inhibiting cancer stem cell metabolism and stemness through CAV1/ZNF460/GRP78 signaling.,2026,10.1016/j.phymed.2026.158317,https://pubmed.ncbi.nlm.nih.gov/42177885/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,38842055,ATG10S promotes IFNL1 expression and autophagic degradation of multiple viral proteins mediated by IFNL1.,2024,10.1080/15548627.2024.2361580,https://pubmed.ncbi.nlm.nih.gov/38842055/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF460,ENSG00000197714,Unsafe,15004467,"Characterization of two novel KRAB-domain-containing zinc finger genes, ZNF460 and ZNF461, on human chromosome 19q13.1-->q13.4.",2003,10.1159/000076292,https://pubmed.ncbi.nlm.nih.gov/15004467/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF483,ENSG00000173258,Unsafe,38951643,Understanding the genetic complexity of puberty timing across the allele frequency spectrum.,2024,10.1038/s41588-024-01798-4,https://pubmed.ncbi.nlm.nih.gov/38951643/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF483,ENSG00000173258,Unsafe,39320385,Targeting cis-p-tau and neuro-related gene expression in traumatic brain injury: therapeutic insights from TC-DAPK6 treatment in mice.,2024,10.1007/s11033-024-09945-0,https://pubmed.ncbi.nlm.nih.gov/39320385/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF483,ENSG00000173258,Unsafe,39256164,Lack of a genetic risk continuum between pubertal timing in the general population and idiopathic hypogonadotropic hypogonadism.,2024,10.1111/jne.13445,https://pubmed.ncbi.nlm.nih.gov/39256164/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF483,ENSG00000173258,Unsafe,34192606,Zinc finger protein 483 (ZNF483) regulates neuronal differentiation and methyl-CpG-binding protein 2 (MeCP2) intracellular localization.,2021,10.1016/j.bbrc.2021.06.066,https://pubmed.ncbi.nlm.nih.gov/34192606/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF483,ENSG00000173258,Unsafe,37298233,"Transcriptome Profiling of Prostate Cancer, Considering Risk Groups and the TMPRSS2-ERG Molecular Subtype.",2023,10.3390/ijms24119282,https://pubmed.ncbi.nlm.nih.gov/37298233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF483,ENSG00000173258,Unsafe,39126614,Whole-genome sequencing identifies novel genes for autism in Chinese trios.,2024,10.1007/s11427-023-2564-8,https://pubmed.ncbi.nlm.nih.gov/39126614/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF483,ENSG00000173258,Unsafe,34008346,Gene transcripts expressed in equine white blood cells are potential biomarkers of extracorporeal shock wave therapy.,2022,10.1002/dta.3099,https://pubmed.ncbi.nlm.nih.gov/34008346/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF483,ENSG00000173258,Unsafe,30641629,[Effect of Heixiaoyao Powder on Hippocampal Gene Expression Profile of Alzheimer's Disease Rats].,2016,,https://pubmed.ncbi.nlm.nih.gov/30641629/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF483,ENSG00000173258,Unsafe,29198826,TRIM28 and Interacting KRAB-ZNFs Control Self-Renewal of Human Pluripotent Stem Cells through Epigenetic Repression of Pro-differentiation Genes.,2017,10.1016/j.stemcr.2017.10.031,https://pubmed.ncbi.nlm.nih.gov/29198826/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF483,ENSG00000173258,Unsafe,30862934,Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures.,2019,10.1038/s41598-019-40786-1,https://pubmed.ncbi.nlm.nih.gov/30862934/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF483,ENSG00000173258,Unsafe,29077908,Differential Impact of Genetic Loci on Age at Thelarche and Menarche in Healthy Girls.,2018,10.1210/jc.2017-01860,https://pubmed.ncbi.nlm.nih.gov/29077908/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF483,ENSG00000173258,Unsafe,23667675,Genome wide association study of age at menarche in the Japanese population.,2013,10.1371/journal.pone.0063821,https://pubmed.ncbi.nlm.nih.gov/23667675/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF483,ENSG00000173258,Unsafe,22131368,Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study.,2012,10.1093/hmg/ddr570,https://pubmed.ncbi.nlm.nih.gov/22131368/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF485,ENSG00000198298,Unsafe,38993359,"A New Functional Gene, Zinc Finger Protein 485 (ZNF485), is Involved in Bladder Cancer Proliferation.",2022,10.3233/blc-211623,https://pubmed.ncbi.nlm.nih.gov/38993359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF490,ENSG00000188033,Unsafe,41603184,An Immune Cell Activation Signature for Non - Small Cell Lung Cancer Revealed Tumor Microenvironment Heterogeneity and the Role of RORA in Regulating ZNF490/NDUFA12 Axis.,2026,10.2174/0109298673399740251007015341,https://pubmed.ncbi.nlm.nih.gov/41603184/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF490,ENSG00000188033,Unsafe,40482318,Infrared-A (IR-A) modulates the p53 pathway and diurnal clock in human skin and subcutaneous adipose tissue in vivo.,2025,10.1016/j.jphotobiol.2025.113199,https://pubmed.ncbi.nlm.nih.gov/40482318/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF490,ENSG00000188033,Unsafe,30719424,Gene Expression and Methylation Analysis in Melanomas and Melanocytes From the Same Patient: Loss of NPM2 Expression Is a Potential Immunohistochemical Marker for Melanoma.,2018,10.3389/fonc.2018.00675,https://pubmed.ncbi.nlm.nih.gov/30719424/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF490,ENSG00000188033,Unsafe,24146633,Eleven candidate susceptibility genes for common familial colorectal cancer.,2013,10.1371/journal.pgen.1003876,https://pubmed.ncbi.nlm.nih.gov/24146633/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF490,ENSG00000188033,Unsafe,23164283,The genetic regulation of the terminating phase of liver regeneration.,2012,10.1186/1476-5926-11-3,https://pubmed.ncbi.nlm.nih.gov/23164283/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF492,ENSG00000229676,Unsafe,38652878,Trans-Ancestral Genetic Risk Factors for Treatment-Related Type 2 Diabetes Mellitus in Survivors of Childhood Cancer.,2024,10.1200/jco.23.02281,https://pubmed.ncbi.nlm.nih.gov/38652878/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF492,ENSG00000229676,Unsafe,36860864,Research into the characteristic molecules significantly affecting liver cancer immunotherapy.,2023,10.3389/fimmu.2023.1029427,https://pubmed.ncbi.nlm.nih.gov/36860864/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF492,ENSG00000229676,Unsafe,34066484,Cell-Free DNA Analysis by Whole-Exome Sequencing for Hepatocellular Carcinoma: A Pilot Study in Thailand.,2021,10.3390/cancers13092229,https://pubmed.ncbi.nlm.nih.gov/34066484/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF492,ENSG00000229676,Unsafe,32489015,"Epigenetic and transcriptomic consequences of excess X-chromosome material in 47,XXX syndrome-A comparison with Turner syndrome and 46,XX females.",2020,10.1002/ajmg.c.31799,https://pubmed.ncbi.nlm.nih.gov/32489015/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF492,ENSG00000229676,Unsafe,16714237,Identification of a KRAB-zinc finger protein binding to the Rpe65 gene promoter.,2006,10.1080/02713680600678059,https://pubmed.ncbi.nlm.nih.gov/16714237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF525,ENSG00000203326,Unsafe,35281811,Comprehensive Analysis of a Zinc Finger Protein Gene-Based Signature with Regard to Prognosis and Tumor Immune Microenvironment in Osteosarcoma.,2022,10.3389/fgene.2022.835014,https://pubmed.ncbi.nlm.nih.gov/35281811/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF527,ENSG00000189164,Unsafe,41471859,Comprehensive Bioinformatics Analysis the circRNAs of Viral Infection Associated Pathway in HepG2 Expressing ORF3 of Genotype IV Swine Hepatitis E Virus.,2025,10.3390/microorganisms13122654,https://pubmed.ncbi.nlm.nih.gov/41471859/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF541,ENSG00000118156,Unsafe,38643268,Integrative analysis in head and neck cancer reveals distinct role of miRNome and methylome as tumour epigenetic drivers.,2024,10.1038/s41598-024-59312-z,https://pubmed.ncbi.nlm.nih.gov/38643268/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF541,ENSG00000118156,Unsafe,36531250,Identification and validation of a prognostic model based on ferroptosis-associated genes in head and neck squamous cancer.,2022,10.3389/fgene.2022.1065546,https://pubmed.ncbi.nlm.nih.gov/36531250/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF541,ENSG00000118156,Unsafe,35846149,Identification of a Prognostic Model Based on Fatty Acid Metabolism-Related Genes of Head and Neck Squamous Cell Carcinoma.,2022,10.3389/fgene.2022.888764,https://pubmed.ncbi.nlm.nih.gov/35846149/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF541,ENSG00000118156,Unsafe,34504527,Developing ZNF Gene Signatures Predicting Radiosensitivity of Patients with Breast Cancer.,2021,10.1155/2021/9255494,https://pubmed.ncbi.nlm.nih.gov/34504527/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF541,ENSG00000118156,Unsafe,34298834,HPV Infection Leaves a DNA Methylation Signature in Oropharyngeal Cancer Affecting Both Coding Genes and Transposable Elements.,2021,10.3390/cancers13143621,https://pubmed.ncbi.nlm.nih.gov/34298834/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF541,ENSG00000118156,Unsafe,31456134,Transcriptome sequencing profiles of cervical cancer tissues and SiHa cells.,2020,10.1007/s10142-019-00706-y,https://pubmed.ncbi.nlm.nih.gov/31456134/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF541,ENSG00000118156,Unsafe,25230004,19q13.32 microdeletion syndrome: three new cases.,2014,10.1016/j.ejmg.2014.08.009,https://pubmed.ncbi.nlm.nih.gov/25230004/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF541,ENSG00000118156,Unsafe,38384136,Natural killer cell-based signature: Prognostic analysis in head and neck squamous cell carcinoma.,2024,10.1002/jgm.3671,https://pubmed.ncbi.nlm.nih.gov/38384136/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF543,ENSG00000178229,Unsafe,35467255,CRISPR/Cas9-Mediated Disruption of ZNF543 Gene: An Approach Toward Discovering Its Relation to TRIM28 Gene in Parkinson's Disease.,2023,10.1007/s12033-022-00494-0,https://pubmed.ncbi.nlm.nih.gov/35467255/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF543,ENSG00000178229,Unsafe,34975305,Identification of Immune Cells and Key Genes associated with Alzheimer's Disease.,2022,10.7150/ijms.66422,https://pubmed.ncbi.nlm.nih.gov/34975305/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF543,ENSG00000178229,Unsafe,36793283,"Systematic analysis of the BET family in adrenocortical carcinoma: The expression, prognosis, gene regulation network, and regulation targets.",2023,10.3389/fendo.2023.1089531,https://pubmed.ncbi.nlm.nih.gov/36793283/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF543,ENSG00000178229,Unsafe,29717273,Identification of an episignature of human colorectal cancer associated with obesity by genome-wide DNA methylation analysis.,2019,10.1038/s41366-018-0065-6,https://pubmed.ncbi.nlm.nih.gov/29717273/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF546,ENSG00000187187,Unsafe,42374823,Gestational Feed Restriction Induces Differential Expression of Novel Long Non-Coding RNAs in Offspring Skeletal Muscle.,2026,10.1002/age.70160,https://pubmed.ncbi.nlm.nih.gov/42374823/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF546,ENSG00000187187,Unsafe,29953444,Genetic contributions to lupus nephritis in a multi-ethnic cohort of systemic lupus erythematous patients.,2018,10.1371/journal.pone.0199003,https://pubmed.ncbi.nlm.nih.gov/29953444/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF548,ENSG00000188785,Unsafe,42463670,Network-based discovery of regulatory drivers of cognitive decline in alzheimer's disease.,2026,10.1038/s41514-026-00443-0,https://pubmed.ncbi.nlm.nih.gov/42463670/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF555,ENSG00000186300,Unsafe,38294620,lncRNA TTTY14 participates in the progression of repeated implantation failure by regulating the miR-6088/SEMA5A axis.,2024,10.1007/s10815-024-03032-w,https://pubmed.ncbi.nlm.nih.gov/38294620/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF555,ENSG00000186300,Unsafe,39009887,DiPRO1 distinctly reprograms muscle and mesenchymal cancer cells.,2024,10.1038/s44321-024-00097-z,https://pubmed.ncbi.nlm.nih.gov/39009887/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF555,ENSG00000186300,Unsafe,35709667,Mixed model-based eQTL analysis reveals lncRNAs associated with regulation of genes involved in sex determination and spermatogenesis: The key to understanding human gender imbalance.,2022,10.1016/j.compbiolchem.2022.107713,https://pubmed.ncbi.nlm.nih.gov/35709667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF555,ENSG00000186300,Unsafe,26184877,ZNF555 protein binds to transcriptional activator site of 4qA allele and ANT1: potential implication in Facioscapulohumeral dystrophy.,2015,10.1093/nar/gkv721,https://pubmed.ncbi.nlm.nih.gov/26184877/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF555,ENSG00000186300,Unsafe,31432148,Characterization of the human zinc finger nfx‑1‑type containing 1 encoding ZNFX1 gene and its response to 12‑O‑tetradecanoyl‑13‑acetate in HL‑60 cells.,2019,10.3892/ijo.2019.4860,https://pubmed.ncbi.nlm.nih.gov/31432148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF555,ENSG00000186300,Unsafe,22678113,A genome-wide analysis of 'Bounty' descendants implicates several novel variants in migraine susceptibility.,2012,10.1007/s10048-012-0325-x,https://pubmed.ncbi.nlm.nih.gov/22678113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF559,ENSG00000188321,Unsafe,41170773,Differential DNA methylation and gene expression in stem cell-derived cardiomyocytes from patients with and without a history of clozapine-induced myocarditis.,2025,10.1139/jpn-25-0017,https://pubmed.ncbi.nlm.nih.gov/41170773/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF559,ENSG00000188321,Unsafe,41778435,Potential Therapeutic Targets for Neuroblastoma Screened through Mendelian Randomization Analysis.,2025,10.34172/aim.35114,https://pubmed.ncbi.nlm.nih.gov/41778435/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF559,ENSG00000188321,Unsafe,16367923,Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.,2006,10.1111/j.1349-7006.2006.00136.x,https://pubmed.ncbi.nlm.nih.gov/16367923/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF564,ENSG00000249709,Unsafe,42012806,Multi-Scale Genetic and Transcriptomic Analyses Identify Druggable Targets for Epilepsy.,2026,10.1007/s11596-026-00194-9,https://pubmed.ncbi.nlm.nih.gov/42012806/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF564,ENSG00000249709,Unsafe,39333211,Identification of common biomarkers in diabetic kidney disease and cognitive dysfunction using machine learning algorithms.,2024,10.1038/s41598-024-72327-w,https://pubmed.ncbi.nlm.nih.gov/39333211/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF564,ENSG00000249709,Unsafe,34414857,Long non-coding RNA ZFAS1 alleviates bupivacaine-induced neurotoxicity by regulating the miR-421/zinc finger protein564 (ZNF564) axis.,2021,10.1080/21655979.2021.1960776,https://pubmed.ncbi.nlm.nih.gov/34414857/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF564,ENSG00000249709,Unsafe,34992653,Identification and External Validation of a Transcription Factor-Related Prognostic Signature in Pediatric Neuroblastoma.,2021,10.1155/2021/1370451,https://pubmed.ncbi.nlm.nih.gov/34992653/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF565,ENSG00000196357,Unsafe,28561737,Synergistic interactions with PI3K inhibition that induce apoptosis.,2017,10.7554/elife.24523,https://pubmed.ncbi.nlm.nih.gov/28561737/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF568,ENSG00000198453,Unsafe,36292594,Genomic Predictors of Brisk Walking Are Associated with Elite Sprinter Status.,2022,10.3390/genes13101710,https://pubmed.ncbi.nlm.nih.gov/36292594/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF568,ENSG00000198453,Unsafe,32034058,Integrated characterisation of cancer genes identifies key molecular biomarkers in stomach adenocarcinoma.,2020,10.1136/jclinpath-2019-206400,https://pubmed.ncbi.nlm.nih.gov/32034058/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF568,ENSG00000198453,Unsafe,28257124,Hyper-Methylated Loci Persisting from Sessile Serrated Polyps to Serrated Cancers.,2017,10.3390/ijms18030535,https://pubmed.ncbi.nlm.nih.gov/28257124/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF568,ENSG00000198453,Unsafe,31953506,Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients.,2020,10.1038/s41598-019-57358-y,https://pubmed.ncbi.nlm.nih.gov/31953506/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF569,ENSG00000196437,Unsafe,41952686,Novel transcriptomic alterations in poorly differentiated endometrial carcinomas: evidence from South African women.,2026,10.3389/fonc.2026.1694662,https://pubmed.ncbi.nlm.nih.gov/41952686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF569,ENSG00000196437,Unsafe,36670548,DNA methylation biomarkers accurately detect esophageal cancer prior and post neoadjuvant chemoradiation.,2023,10.1002/cam4.5623,https://pubmed.ncbi.nlm.nih.gov/36670548/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF569,ENSG00000196437,Unsafe,31258729,Identification of novel methylated DNA marker ZNF569 for head and neck squamous cell carcinoma.,2019,10.7150/jca.31156,https://pubmed.ncbi.nlm.nih.gov/31258729/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF569,ENSG00000196437,Unsafe,33292587,A DNA methylation-based test for esophageal cancer detection.,2020,10.1186/s40364-020-00248-7,https://pubmed.ncbi.nlm.nih.gov/33292587/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF569,ENSG00000196437,Unsafe,32707444,The utility of a methylation panel in the assessment of clinical response to radiofrequency ablation for Barrett's esophagus.,2020,10.1016/j.ebiom.2020.102877,https://pubmed.ncbi.nlm.nih.gov/32707444/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF569,ENSG00000196437,Unsafe,29084829,Methylation panel is a diagnostic biomarker for Barrett's oesophagus in endoscopic biopsies and non-endoscopic cytology specimens.,2018,10.1136/gutjnl-2017-314026,https://pubmed.ncbi.nlm.nih.gov/29084829/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF569,ENSG00000196437,Unsafe,29844130,"Detection of Gastric Cancer with Novel Methylated DNA Markers: Discovery, Tissue Validation, and Pilot Testing in Plasma.",2018,10.1158/1078-0432.ccr-17-3364,https://pubmed.ncbi.nlm.nih.gov/29844130/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF569,ENSG00000196437,Unsafe,16793018,"ZNF569, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway.",2006,10.1016/j.bbrc.2006.05.109,https://pubmed.ncbi.nlm.nih.gov/16793018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF569,ENSG00000196437,Unsafe,24699359,Protein quantitative trait loci identify novel candidates modulating cellular response to chemotherapy.,2014,10.1371/journal.pgen.1004192,https://pubmed.ncbi.nlm.nih.gov/24699359/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF570,ENSG00000171827,Unsafe,41857240,Targeting ZNF570 activates ferroptosis to reverse tamoxifen resistance in ER + breast cancer cells.,2026,10.1007/s00210-026-05171-6,https://pubmed.ncbi.nlm.nih.gov/41857240/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF570,ENSG00000171827,Unsafe,28852427,Seven-CpG-based prognostic signature coupled with gene expression predicts survival of oral squamous cell carcinoma.,2017,10.1186/s13148-017-0392-9,https://pubmed.ncbi.nlm.nih.gov/28852427/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF570,ENSG00000171827,Unsafe,26921073,Chromosomal aneuploidies induced upon Lamin B2 depletion are mislocalized in the interphase nucleus.,2017,10.1007/s00412-016-0580-y,https://pubmed.ncbi.nlm.nih.gov/26921073/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF571,ENSG00000180479,Unsafe,42840284,Epigenetic profiling of preterm birth: a dual-tissue methylation patterns using long-read sequencing.,2025,10.3389/freae.2025.1644521,https://pubmed.ncbi.nlm.nih.gov/42840284/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF571,ENSG00000180479,Unsafe,33936172,Identification and Functional Prediction of Long Non-Coding RNAs in Dilated Cardiomyopathy by Bioinformatics Analysis.,2021,10.3389/fgene.2021.648111,https://pubmed.ncbi.nlm.nih.gov/33936172/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF571,ENSG00000180479,Unsafe,36214709,Comprehensive analysis of lncRNA‑miRNA‑mRNA regulatory networks for Alzheimer's disease.,2022,10.55782/ane-2022-025,https://pubmed.ncbi.nlm.nih.gov/36214709/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF571,ENSG00000180479,Unsafe,34350836,An lncRNA-miRNA-mRNA-ceRNA network regulates intervertebral disc degeneration: A bioinformatics study based on the dataset analysis.,2021,10.4149/gpb_2021013,https://pubmed.ncbi.nlm.nih.gov/34350836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF571,ENSG00000180479,Unsafe,28204819,lncRNA co-expression network model for the prognostic analysis of acute myeloid leukemia.,2017,10.3892/ijmm.2017.2888,https://pubmed.ncbi.nlm.nih.gov/28204819/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF572,ENSG00000180938,Unsafe,39287932,Identification of risk loci for postpartum depression in a genome-wide association study.,2024,10.1111/pcn.13731,https://pubmed.ncbi.nlm.nih.gov/39287932/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF572,ENSG00000180938,Unsafe,35361790,Identification of a novel gene signature in second-trimester amniotic fluid for the prediction of preterm birth.,2022,10.1038/s41598-021-04709-3,https://pubmed.ncbi.nlm.nih.gov/35361790/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF573,ENSG00000189144,Unsafe,40973794,Aging-associated ZNF573 methylation regulates RNF19B-PIK3CA ubiquitination to promote prostate cancer.,2025,10.1038/s41388-025-03579-7,https://pubmed.ncbi.nlm.nih.gov/40973794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF573,ENSG00000189144,Unsafe,41952686,Novel transcriptomic alterations in poorly differentiated endometrial carcinomas: evidence from South African women.,2026,10.3389/fonc.2026.1694662,https://pubmed.ncbi.nlm.nih.gov/41952686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF573,ENSG00000189144,Unsafe,34995016,A combined biomarker panel shows improved sensitivity and specificity for detection of ovarian cancer.,2022,10.1002/jcla.24232,https://pubmed.ncbi.nlm.nih.gov/34995016/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF573,ENSG00000189144,Unsafe,36672361,Serum Mass Spectrometry Proteomics and Protein Set Identification in Response to FOLFOX-4 in Drug-Resistant Ovarian Carcinoma.,2023,10.3390/cancers15020412,https://pubmed.ncbi.nlm.nih.gov/36672361/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF573,ENSG00000189144,Unsafe,26671628,Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression.,2015,10.1038/ncomms10195,https://pubmed.ncbi.nlm.nih.gov/26671628/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF573,ENSG00000189144,Unsafe,30362566,The transcriptome profiles and methylation status revealed the potential cancer-related lncRNAs in patients with cervical cancer.,2019,10.1002/jcp.27661,https://pubmed.ncbi.nlm.nih.gov/30362566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF573,ENSG00000189144,Unsafe,30664178,Identification of key genes and pathways involved in microsatellite instability in colorectal cancer.,2019,10.3892/mmr.2019.9849,https://pubmed.ncbi.nlm.nih.gov/30664178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF578,ENSG00000258405,Unsafe,40682633,Targeted screening and single-cell analysis of genetic variants in melanoma using Mendelian randomization.,2025,10.1007/s12672-025-03225-4,https://pubmed.ncbi.nlm.nih.gov/40682633/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF578,ENSG00000258405,Unsafe,25625310,Prevalence of chromosomal rearrangements involving non-ETS genes in prostate cancer.,2015,10.3892/ijo.2015.2855,https://pubmed.ncbi.nlm.nih.gov/25625310/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF583,ENSG00000198440,Unsafe,37980450,Single-cell and bulk RNA sequencing reveals Anoikis related genes to guide prognosis and immunotherapy in osteosarcoma.,2023,10.1038/s41598-023-47367-3,https://pubmed.ncbi.nlm.nih.gov/37980450/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF583,ENSG00000198440,Unsafe,30076325,Differentially expressed genes related to major depressive disorder and antidepressant response: genome-wide gene expression analysis.,2018,10.1038/s12276-018-0123-0,https://pubmed.ncbi.nlm.nih.gov/30076325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF583,ENSG00000198440,Unsafe,29762666,Discovery and Validation of Methylation Biomarkers for Ulcerative Colitis Associated Neoplasia.,2018,10.1093/ibd/izy119,https://pubmed.ncbi.nlm.nih.gov/29762666/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF583,ENSG00000198440,Unsafe,21636702,Novel candidate colorectal cancer biomarkers identified by methylation microarray-based scanning.,2011,10.1530/erc-11-0083,https://pubmed.ncbi.nlm.nih.gov/21636702/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF587,ENSG00000198466,Unsafe,41969615,Panomics Integration via Machine Learning Prioritizes TAF1D as a Therapeutic Vulnerability in Lung Adenocarcinoma.,2026,10.1155/humu/1816649,https://pubmed.ncbi.nlm.nih.gov/41969615/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF587,ENSG00000198466,Unsafe,38345497,A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress-Induced Inflammation.,2024,10.1158/0008-5472.can-23-1237,https://pubmed.ncbi.nlm.nih.gov/38345497/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF587,ENSG00000198466,Unsafe,34670480,MiRNA-4537 functions as a tumor suppressor in gastric cancer and increases the radiosensitivity of gastric cancer cells.,2021,10.1080/21655979.2021.1982843,https://pubmed.ncbi.nlm.nih.gov/34670480/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF587,ENSG00000198466,Unsafe,36181243,The long non-sacoding RNA TMEM147-AS1/miR-133b/ZNF587 axis regulates the Warburg effect and promotes prostatic carcinoma invasion and proliferation.,2022,10.1002/jgm.3453,https://pubmed.ncbi.nlm.nih.gov/36181243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF587,ENSG00000198466,Unsafe,32923624,Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons.,2020,10.1126/sciadv.aba3200,https://pubmed.ncbi.nlm.nih.gov/32923624/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF587,ENSG00000198466,Unsafe,35259018,Species-specific KRAB-ZFPs function as repressors of retroviruses by targeting PBS regions.,2022,10.1073/pnas.2119415119,https://pubmed.ncbi.nlm.nih.gov/35259018/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF587,ENSG00000198466,Unsafe,30076325,Differentially expressed genes related to major depressive disorder and antidepressant response: genome-wide gene expression analysis.,2018,10.1038/s12276-018-0123-0,https://pubmed.ncbi.nlm.nih.gov/30076325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF593,ENSG00000142684,Unsafe,40210981,ZNF593 regulates the cGAS-mediated innate immune response by attenuating cGAS-DNA binding.,2025,10.1038/s41418-025-01508-5,https://pubmed.ncbi.nlm.nih.gov/40210981/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF593,ENSG00000142684,Unsafe,39758980,Zinc finger protein 593 promotes breast cancer development by ensuring DNA damage repair and cell-cycle progression.,2024,10.1016/j.isci.2024.111513,https://pubmed.ncbi.nlm.nih.gov/39758980/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF593,ENSG00000142684,Unsafe,38743133,lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression.,2024,10.1007/s11684-023-1036-4,https://pubmed.ncbi.nlm.nih.gov/38743133/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF593,ENSG00000142684,Unsafe,37215148,LncRNA ZNF593-AS alleviates diabetic cardiomyopathy via suppressing IRF3 signaling pathway.,2023,10.1016/j.omtn.2023.04.025,https://pubmed.ncbi.nlm.nih.gov/37215148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF593,ENSG00000142684,Unsafe,38726870,Reduction of ZFX levels decreases histone H4 acetylation and increases Pol2 pausing at target promoters.,2024,10.1093/nar/gkae372,https://pubmed.ncbi.nlm.nih.gov/38726870/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF593,ENSG00000142684,Unsafe,33550812,LncRNA ZNF593-AS Alleviates Contractile Dysfunction in Dilated Cardiomyopathy.,2021,10.1161/circresaha.120.318437,https://pubmed.ncbi.nlm.nih.gov/33550812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF593,ENSG00000142684,Unsafe,31185901,Multiple stressors produce differential transcriptomic patterns in a stream-dwelling salamander.,2019,10.1186/s12864-019-5814-y,https://pubmed.ncbi.nlm.nih.gov/31185901/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF593,ENSG00000142684,Unsafe,18287285,The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominantly unstructured protein.,2008,10.1110/ps.073290408,https://pubmed.ncbi.nlm.nih.gov/18287285/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF593,ENSG00000142684,Unsafe,9115366,A novel genetic system to isolate a dominant negative effector on DNA-binding activity of Oct-2.,1997,10.1093/nar/25.10.1984,https://pubmed.ncbi.nlm.nih.gov/9115366/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF597,ENSG00000167981,Unsafe,42789309,Differential methylation at novel putative imprinting control regions on chromosome 20 associated with childhood obesity.,2026,10.1080/15592294.2026.2732477,https://pubmed.ncbi.nlm.nih.gov/42789309/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF597,ENSG00000167981,Unsafe,40943441,Clinical and Molecular Presentation of a Patient with Paternal Uniparental Isodisomy of Chromosome 16.,2025,10.3390/ijms26178521,https://pubmed.ncbi.nlm.nih.gov/40943441/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF597,ENSG00000167981,Unsafe,40646471,Genome-wide association studies and candidate genes networks affecting reproductive traits using Iranian Holstein sequence data.,2025,10.1186/s12864-025-11744-1,https://pubmed.ncbi.nlm.nih.gov/40646471/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF597,ENSG00000167981,Unsafe,40691194,Machine learning in Alzheimer's disease genetics.,2025,10.1038/s41467-025-61650-z,https://pubmed.ncbi.nlm.nih.gov/40691194/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF597,ENSG00000167981,Unsafe,32576657,Loss of imprinting of the human-specific imprinted gene ZNF597 causes prenatal growth retardation and dysmorphic features: implications for phenotypic overlap with Silver-Russell syndrome.,2021,10.1136/jmedgenet-2020-107019,https://pubmed.ncbi.nlm.nih.gov/32576657/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF597,ENSG00000167981,Unsafe,35281811,Comprehensive Analysis of a Zinc Finger Protein Gene-Based Signature with Regard to Prognosis and Tumor Immune Microenvironment in Osteosarcoma.,2022,10.3389/fgene.2022.835014,https://pubmed.ncbi.nlm.nih.gov/35281811/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF597,ENSG00000167981,Unsafe,31874365,ZNF597 is a maternally expressed imprinted gene in the Holstein breed.,2020,10.1016/j.theriogenology.2019.12.007,https://pubmed.ncbi.nlm.nih.gov/31874365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF597,ENSG00000167981,Unsafe,28864461,Somatic uniparental disomy of Chromosome 16p in hemimegalencephaly.,2017,10.1101/mcs.a001735,https://pubmed.ncbi.nlm.nih.gov/28864461/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF597,ENSG00000167981,Unsafe,30242100,Molecular and clinical analyses of two patients with UPD(16)mat detected by screening 94 patients with Silver-Russell syndrome phenotype of unknown aetiology.,2019,10.1136/jmedgenet-2018-105463,https://pubmed.ncbi.nlm.nih.gov/30242100/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF597,ENSG00000167981,Unsafe,30961659,Novel parent-of-origin-specific differentially methylated loci on chromosome 16.,2019,10.1186/s13148-019-0655-8,https://pubmed.ncbi.nlm.nih.gov/30961659/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF597,ENSG00000167981,Unsafe,27632690,Genome-wide multilocus imprinting disturbance analysis in Temple syndrome and Kagami-Ogata syndrome.,2017,10.1038/gim.2016.123,https://pubmed.ncbi.nlm.nih.gov/27632690/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF597,ENSG00000167981,Unsafe,19968752,"Molecular characterization and gene disruption of a novel zinc-finger protein, HIT-4, expressed in rodent brain.",2010,10.1111/j.1471-4159.2009.06525.x,https://pubmed.ncbi.nlm.nih.gov/19968752/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF597,ENSG00000167981,Unsafe,22894909,A genome-wide approach reveals novel imprinted genes expressed in the human placenta.,2012,10.4161/epi.21495,https://pubmed.ncbi.nlm.nih.gov/22894909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF597,ENSG00000167981,Unsafe,21324877,A novel approach identifies new differentially methylated regions (DMRs) associated with imprinted genes.,2011,10.1101/gr.111922.110,https://pubmed.ncbi.nlm.nih.gov/21324877/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF597,ENSG00000167981,Unsafe,21593219,Methylation screening of reciprocal genome-wide UPDs identifies novel human-specific imprinted genes.,2011,10.1093/hmg/ddr224,https://pubmed.ncbi.nlm.nih.gov/21593219/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF607,ENSG00000198182,Unsafe,21314952,Bioinformatic analyses identifies novel protein-coding pharmacogenomic markers associated with paclitaxel sensitivity in NCI60 cancer cell lines.,2011,10.1186/1755-8794-4-18,https://pubmed.ncbi.nlm.nih.gov/21314952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF610,ENSG00000167554,Unsafe,38898665,Silencing of ZNF610 suppresses cell proliferation and migration in lung adenocarcinoma.,2024,10.1002/cbf.4078,https://pubmed.ncbi.nlm.nih.gov/38898665/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF610,ENSG00000167554,Unsafe,41559687,Targeting mechanosensitive cannabinoid receptor 1 with isoflavone prodrugs attenuates atherosclerotic endothelial dysfunction.,2026,10.1186/s12929-026-01214-5,https://pubmed.ncbi.nlm.nih.gov/41559687/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF610,ENSG00000167554,Unsafe,41154714,Bioinformatics-Based Analysis of the Screening and Evaluation of Potential Targets of FTY720 for the Treatment of Non-Small Cell Lung Cancer.,2025,10.3390/biology14101311,https://pubmed.ncbi.nlm.nih.gov/41154714/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF610,ENSG00000167554,Unsafe,26269563,DNA Methylation Predicts Progression of Human Gastric Lesions.,2015,10.1158/1055-9965.epi-15-0388,https://pubmed.ncbi.nlm.nih.gov/26269563/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF610,ENSG00000167554,Unsafe,33552133,Gene Expression Changes and Associated Pathways Involved in the Progression of Prostate Cancer Advanced Stages.,2020,10.3389/fgene.2020.613162,https://pubmed.ncbi.nlm.nih.gov/33552133/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF610,ENSG00000167554,Unsafe,29927694,DNA methylation biomarkers for head and neck squamous cell carcinoma.,2018,10.1080/15592294.2018.1465790,https://pubmed.ncbi.nlm.nih.gov/29927694/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF610,ENSG00000167554,Unsafe,24128875,Virulence of infecting Helicobacter pylori strains and intensity of mononuclear cell infiltration are associated with levels of DNA hypermethylation in gastric mucosae.,2013,10.4161/epi.26072,https://pubmed.ncbi.nlm.nih.gov/24128875/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF611,ENSG00000213020,Unsafe,42323373,Genome-wide DNA methylation profiling during metabolic dysfunction-associated steatohepatitis-related hepatocarcinogenesis in patients in Japan and the United States.,2026,10.1038/s41598-026-57253-3,https://pubmed.ncbi.nlm.nih.gov/42323373/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF611,ENSG00000213020,Unsafe,41221278,Construction of a prognostic model based on palmitoylation-related lncRNAs for assessing drug benefits in breast cancer.,2025,10.3389/fimmu.2025.1656593,https://pubmed.ncbi.nlm.nih.gov/41221278/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF611,ENSG00000213020,Unsafe,33883344,Detection of novel and recurrent conjoined genes in non-Hodgkin B-cell lymphoma.,2021,10.3960/jslrt.20033,https://pubmed.ncbi.nlm.nih.gov/33883344/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF611,ENSG00000213020,Unsafe,33722937,ZNF91 deletion in human embryonic stem cells leads to ectopic activation of SVA retrotransposons and up-regulation of KRAB zinc finger gene clusters.,2021,10.1101/gr.265348.120,https://pubmed.ncbi.nlm.nih.gov/33722937/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF611,ENSG00000213020,Unsafe,31692007,Weighted gene co-expression network analysis to explore the mechanism of heroin addiction in human nucleus accumbens.,2020,10.1002/jcb.29422,https://pubmed.ncbi.nlm.nih.gov/31692007/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF611,ENSG00000213020,Unsafe,26290131,X-linked intellectual disability related genes disrupted by balanced X-autosome translocations.,2015,10.1002/ajmg.b.32355,https://pubmed.ncbi.nlm.nih.gov/26290131/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF611,ENSG00000213020,Unsafe,30938061,New insights into radioresistance in breast cancer identify a dual function of miR-122 as a tumor suppressor and oncomiR.,2019,10.1002/1878-0261.12483,https://pubmed.ncbi.nlm.nih.gov/30938061/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF611,ENSG00000213020,Unsafe,30664178,Identification of key genes and pathways involved in microsatellite instability in colorectal cancer.,2019,10.3892/mmr.2019.9849,https://pubmed.ncbi.nlm.nih.gov/30664178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF619,ENSG00000177873,Unsafe,31508907,Differentially methylated gene patterns between age-matched sarcopenic and non-sarcopenic women.,2019,10.1002/jcsm.12478,https://pubmed.ncbi.nlm.nih.gov/31508907/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF624,ENSG00000197566,Unsafe,34746177,Genetic Polymorphisms and Clinical Features in Diabetic Patients With Fatty Liver: Results From a Single-Center Experience in Southern Italy.,2021,10.3389/fmed.2021.737759,https://pubmed.ncbi.nlm.nih.gov/34746177/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF624,ENSG00000197566,Unsafe,34341332,Genome-wide DNA methylation and gene expression analyses in monozygotic twins identify potential biomarkers of depression.,2021,10.1038/s41398-021-01536-y,https://pubmed.ncbi.nlm.nih.gov/34341332/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF626,ENSG00000188171,Unsafe,40002911,"Estrogen Promotes Endometrial Cancer Development by Modulating ZNF626, SLK, and RFWD3 Gene Expression and Inducing Immune Inflammatory Changes.",2025,10.3390/biomedicines13020498,https://pubmed.ncbi.nlm.nih.gov/40002911/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF626,ENSG00000188171,Unsafe,41793107,Systematic Multiplatform Discovery of Methylation Markers Enables Non-Invasive Early Detection of Endometrial Cancer.,2026,10.1111/cas.70346,https://pubmed.ncbi.nlm.nih.gov/41793107/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF626,ENSG00000188171,Unsafe,27167565,Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers.,2016,10.1001/jamapsychiatry.2016.0350,https://pubmed.ncbi.nlm.nih.gov/27167565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF646,ENSG00000167395,Unsafe,41006818,Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci.,2025,10.1038/s41366-025-01898-z,https://pubmed.ncbi.nlm.nih.gov/41006818/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF646,ENSG00000167395,Unsafe,41792138,The genetic basis of dermatophytosis skin infection susceptibility.,2026,10.1038/s41467-026-69670-z,https://pubmed.ncbi.nlm.nih.gov/41792138/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF646,ENSG00000167395,Unsafe,40722297,Metabolic Syndrome and Parkinson's Disease: Two Villains Join Forces.,2025,10.3390/brainsci15070706,https://pubmed.ncbi.nlm.nih.gov/40722297/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF646,ENSG00000167395,Unsafe,39954159,Causal association between cerebral small vessel disease and epilepsy.,2025,10.1007/s10143-025-03299-2,https://pubmed.ncbi.nlm.nih.gov/39954159/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF646,ENSG00000167395,Unsafe,33436766,Allele-specific expression of Parkinson's disease susceptibility genes in human brain.,2021,10.1038/s41598-020-79990-9,https://pubmed.ncbi.nlm.nih.gov/33436766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF646,ENSG00000167395,Unsafe,39596350,Transcriptome Analysis of Porcine Immune Cells Stimulated by Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and Caesalpinia sappan Extract.,2024,10.3390/ijms252212285,https://pubmed.ncbi.nlm.nih.gov/39596350/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,42366365,Correction: ZNF655 promotes tumor growth and chemoresistance by targeting MAFF-CCND1 axis in ovarian cancer.,2026,10.1186/s12935-026-04383-3,https://pubmed.ncbi.nlm.nih.gov/42366365/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,41088232,ZNF655 promotes tumor growth and chemoresistance by targeting MAFF-CCND1 axis in ovarian cancer.,2025,10.1186/s12935-025-03997-3,https://pubmed.ncbi.nlm.nih.gov/41088232/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,41352639,ZNF655-mediated neuroprotection in cerebral ischemia-reperfusion injury via Akt/Nrf2 pathway modulation.,2026,10.1016/j.brainres.2025.150091,https://pubmed.ncbi.nlm.nih.gov/41352639/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,40924716,Comprehensive analysis of disulfidptosis-related genes in pulmonary hypertension through machine learning and immune infiltration: Spotlight on USP32 and ZNF655 as key regulators.,2025,10.1371/journal.pone.0330832,https://pubmed.ncbi.nlm.nih.gov/40924716/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,39491549,ZNF655 involved in the progression of multiple myeloma via the activation of AKT.,2025,10.1002/cbin.12256,https://pubmed.ncbi.nlm.nih.gov/39491549/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,42484714,Association of TRPV3 gene polymorphisms with wool production traits in Zhexi Angora rabbits.,2026,10.1007/s00438-026-02486-0,https://pubmed.ncbi.nlm.nih.gov/42484714/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,37272200,ZNF655 promotes the progression of hepatocellular carcinoma through PSMB8.,2023,10.1002/cbin.12050,https://pubmed.ncbi.nlm.nih.gov/37272200/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,41915616,"Gut Microbiome, Immune Cells, and Heart Failure: A Multi-Omics Mendelian Randomization Study.",2026,10.1159/000550655,https://pubmed.ncbi.nlm.nih.gov/41915616/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,35280721,ZNF655 Promotes the Progression of Glioma Through Transcriptional Regulation of AURKA.,2022,10.3389/fonc.2022.770013,https://pubmed.ncbi.nlm.nih.gov/35280721/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,35927248,ZNF655 accelerates progression of pancreatic cancer by promoting the binding of E2F1 and CDK1.,2022,10.1038/s41389-022-00418-2,https://pubmed.ncbi.nlm.nih.gov/35927248/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,39202766,Methylated DNA Markers in Voided Urine for the Identification of Clinically Significant Prostate Cancer.,2024,10.3390/life14081024,https://pubmed.ncbi.nlm.nih.gov/39202766/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,36519409,ZNF655 mediated by LINC01210/miR-124-3p axis promotes the progression of gastric cancer.,2023,10.1002/kjm2.12634,https://pubmed.ncbi.nlm.nih.gov/36519409/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,38500993,Identification of macrophage-related genes correlated with prognosis and immunotherapy efficacy in non-small cell lung cancer.,2024,10.1016/j.heliyon.2024.e27170,https://pubmed.ncbi.nlm.nih.gov/38500993/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,34144060,ZNF655 is involved in development and progression of non-small-cell lung cancer.,2021,10.1016/j.lfs.2021.119727,https://pubmed.ncbi.nlm.nih.gov/34144060/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,32464549,Role of ANKHD1/LINC00346/ZNF655 Feedback Loop in Regulating the Glioma Angiogenesis via Staufen1-Mediated mRNA Decay.,2020,10.1016/j.omtn.2020.05.004,https://pubmed.ncbi.nlm.nih.gov/32464549/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,36434110,Analysis of serum circulating MicroRNAs level in Malaysian patients with gestational diabetes mellitus.,2022,10.1038/s41598-022-23816-3,https://pubmed.ncbi.nlm.nih.gov/36434110/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,34261302,Analysis of H3K4me3-ChIP-Seq and RNA-Seq data to understand the putative role of miRNAs and their target genes in breast cancer cell lines.,2021,10.5808/gi.21020,https://pubmed.ncbi.nlm.nih.gov/34261302/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,32328087,Exome-Wide Association Study Reveals Several Susceptibility Genes and Pathways Associated With Acute Coronary Syndromes in Han Chinese.,2020,10.3389/fgene.2020.00336,https://pubmed.ncbi.nlm.nih.gov/32328087/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF655,ENSG00000197343,Unsafe,30108311,Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.,2020,10.1038/s41380-018-0112-7,https://pubmed.ncbi.nlm.nih.gov/30108311/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF660,ENSG00000144792,Unsafe,40311809,Investigating causal relationships between gene expression and major depressive disorder via brain bulk-tissue and cell type-specific eQTL: A Mendelian randomization and Bayesian colocalization study.,2025,10.1016/j.jad.2025.04.161,https://pubmed.ncbi.nlm.nih.gov/40311809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF660,ENSG00000144792,Unsafe,42748958,Identifying differential interactions of potentially traumatic experiences with genetic risk for posttraumatic stress disorder.,2026,10.1080/20008066.2026.2709319,https://pubmed.ncbi.nlm.nih.gov/42748958/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF660,ENSG00000144792,Unsafe,29465788,Biomarker potential of ST6GALNAC3 and ZNF660 promoter hypermethylation in prostate cancer tissue and liquid biopsies.,2018,10.1002/1878-0261.12183,https://pubmed.ncbi.nlm.nih.gov/29465788/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF668,ENSG00000167394,Unsafe,41614761,Comprehensive Pan-Cancer Analysis of ZNF668 Reveals the Prognostic and Immunological Significance of ZNF668.,2025,10.3390/cimb47120997,https://pubmed.ncbi.nlm.nih.gov/41614761/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF668,ENSG00000167394,Unsafe,37240013,Relationship between the Reduced Expression of Zinc Finger Protein 668 in Bladder Cancer and Its Invasiveness.,2023,10.3390/ijms24108668,https://pubmed.ncbi.nlm.nih.gov/37240013/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF668,ENSG00000167394,Unsafe,40699783,Genome-Wide Detection of Leukemia Biomarkers from lincRNA-Protein-Coding Gene Interaction Networks in the Three-Dimensional Chromatin Structure.,2025,10.3390/cimb47060384,https://pubmed.ncbi.nlm.nih.gov/40699783/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF668,ENSG00000167394,Unsafe,34261923,ZNF668: a new diagnostic predictor of kidney renal clear cell carcinoma.,2022,10.1097/cad.0000000000001149,https://pubmed.ncbi.nlm.nih.gov/34261923/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF668,ENSG00000167394,Unsafe,41286667,Whole-genome analysis reveals genetic diversity and selection pressure in Sichuan donkey.,2025,10.1186/s12864-025-12254-w,https://pubmed.ncbi.nlm.nih.gov/41286667/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF668,ENSG00000167394,Unsafe,34313816,ZNF668 deficiency causes a recognizable disorder of DNA damage repair.,2021,10.1007/s00439-021-02321-z,https://pubmed.ncbi.nlm.nih.gov/34313816/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF668,ENSG00000167394,Unsafe,29556277,Zinc finger protein 668 suppresses non-small cell lung cancer invasion and migration by downregulating Snail and upregulating E-cadherin and zonula occludens-1.,2018,10.3892/ol.2018.7802,https://pubmed.ncbi.nlm.nih.gov/29556277/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF668,ENSG00000167394,Unsafe,35873486,Genomic Diversity and Selection Signatures for Weining Cattle on the Border of Yunnan-Guizhou.,2022,10.3389/fgene.2022.848951,https://pubmed.ncbi.nlm.nih.gov/35873486/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF668,ENSG00000167394,Unsafe,32859265,Assessment of tumor suppressor promoter methylation in healthy individuals.,2020,10.1186/s13148-020-00920-7,https://pubmed.ncbi.nlm.nih.gov/32859265/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF668,ENSG00000167394,Unsafe,23777805,Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage.,2013,10.4161/cc.25064,https://pubmed.ncbi.nlm.nih.gov/23777805/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF668,ENSG00000167394,Unsafe,21852383,ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer.,2011,10.1158/0008-5472.can-11-0853,https://pubmed.ncbi.nlm.nih.gov/21852383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF668,ENSG00000167394,Unsafe,25301550,The JNK1/JNK3 interactome--contributions by the JNK3 unique N-terminus and JNK common docking site residues.,2014,10.1016/j.bbrc.2014.09.122,https://pubmed.ncbi.nlm.nih.gov/25301550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF668,ENSG00000167394,Unsafe,21343389,Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression.,2011,10.1158/0008-5472.can-10-2958,https://pubmed.ncbi.nlm.nih.gov/21343389/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF668,ENSG00000167394,Unsafe,40784299,Dissection of shared genetic architecture and biological association between psoriasis and cardiovascular disease based on genome-wide association studies.,2025,10.1016/j.humimm.2025.111565,https://pubmed.ncbi.nlm.nih.gov/40784299/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF669,ENSG00000188295,Unsafe,37854190,Specific genetic aberrations of parathyroid in Chinese patients with tertiary hyperparathyroidism using whole-exome sequencing.,2023,10.3389/fendo.2023.1221060,https://pubmed.ncbi.nlm.nih.gov/37854190/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF669,ENSG00000188295,Unsafe,30753137,Genetics of aldosterone-producing adenomas with pathogenic KCNJ5 variants.,2019,10.1530/erc-18-0364,https://pubmed.ncbi.nlm.nih.gov/30753137/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF670,ENSG00000277462,Unsafe,33037712,Profiling of specific long non-coding RNA signatures identifies ST8SIA6-AS1 AS a novel target for breast cancer.,2021,10.1002/jgm.3286,https://pubmed.ncbi.nlm.nih.gov/33037712/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF675,ENSG00000197372,Unsafe,38958676,Emergence of the ZNF675 Gene During Primate Evolution-Influenced Human Neurodevelopment Through Changing HES1 Autoregulation.,2024,10.1002/cne.25648,https://pubmed.ncbi.nlm.nih.gov/38958676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF675,ENSG00000197372,Unsafe,36717546,Human zygotic genome activation is initiated from paternal genome.,2023,10.1038/s41421-022-00494-z,https://pubmed.ncbi.nlm.nih.gov/36717546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF675,ENSG00000197372,Unsafe,38622061,Longitudinal profiling of human androgenotes through single-cell analysis unveils paternal gene expression dynamics in early embryo development.,2024,10.1093/humrep/deae072,https://pubmed.ncbi.nlm.nih.gov/38622061/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF675,ENSG00000197372,Unsafe,25056994,Chronic periodontitis genome-wide association studies: gene-centric and gene set enrichment analyses.,2014,10.1177/0022034514544506,https://pubmed.ncbi.nlm.nih.gov/25056994/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF676,ENSG00000196109,Unsafe,38540151,"Associations between ZNF676, CTC1 Gene Polymorphisms and Relative Leukocyte Telomere Length with Myopia and Its Degree.",2024,10.3390/biomedicines12030538,https://pubmed.ncbi.nlm.nih.gov/38540151/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF676,ENSG00000196109,Unsafe,35042549,KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences.,2022,10.1186/s13100-021-00260-0,https://pubmed.ncbi.nlm.nih.gov/35042549/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF676,ENSG00000196109,Unsafe,40107556,Codon usage bias and nucleotide bias are not influenced by the 5' flanking but by 3' and intronic region composition in SCID-associated genes.,2025,10.1016/j.ijbiomac.2025.142182,https://pubmed.ncbi.nlm.nih.gov/40107556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF676,ENSG00000196109,Unsafe,38339395,"The Influence of Telomere-Related Gene Variants, Serum Levels, and Relative Leukocyte Telomere Length in Pituitary Adenoma Occurrence and Recurrence.",2024,10.3390/cancers16030643,https://pubmed.ncbi.nlm.nih.gov/38339395/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF676,ENSG00000196109,Unsafe,37761960,Identification of Breast Cancer Metastasis Markers from Gene Expression Profiles Using Machine Learning Approaches.,2023,10.3390/genes14091820,https://pubmed.ncbi.nlm.nih.gov/37761960/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF676,ENSG00000196109,Unsafe,32887565,Whole exome sequencing highlights variants in association with Keratoconus in Jordanian families.,2020,10.1186/s12881-020-01112-z,https://pubmed.ncbi.nlm.nih.gov/32887565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF676,ENSG00000196109,Unsafe,28382019,Transcriptome Analysis Showed a Differential Signature between Invasive and Non-invasive Corticotrophinomas.,2017,10.3389/fendo.2017.00055,https://pubmed.ncbi.nlm.nih.gov/28382019/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF676,ENSG00000196109,Unsafe,29202958,Transcriptome-wide association study revealed two novel genes associated with nonobstructive azoospermia in a Chinese population.,2017,10.1016/j.fertnstert.2017.09.023,https://pubmed.ncbi.nlm.nih.gov/29202958/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF676,ENSG00000196109,Unsafe,26354067,Replication of the results of genome-wide and candidate gene association studies on telomere length in a Korean population.,2015,10.3904/kjim.2015.30.5.719,https://pubmed.ncbi.nlm.nih.gov/26354067/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF676,ENSG00000196109,Unsafe,23001564,Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans.,2012,10.1093/hmg/dds382,https://pubmed.ncbi.nlm.nih.gov/23001564/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF676,ENSG00000196109,Unsafe,23397585,Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells.,2013,10.1007/s00204-013-1018-4,https://pubmed.ncbi.nlm.nih.gov/23397585/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF676,ENSG00000196109,Unsafe,30097855,Candidate susceptibility variants in angioimmunoblastic T-cell lymphoma.,2019,10.1007/s10689-018-0099-x,https://pubmed.ncbi.nlm.nih.gov/30097855/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF677,ENSG00000197928,Unsafe,35164660,Overexpression of zinc-finger protein 677 inhibits proliferation and invasion by and induces apoptosis in clear cell renal cell carcinoma.,2022,10.1080/21655979.2022.2038891,https://pubmed.ncbi.nlm.nih.gov/35164660/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF677,ENSG00000197928,Unsafe,37129799,ZNF677 inhibits oral squamous cell carcinoma growth and tumor stemness by regulating FOXO3a.,2023,10.1007/s13577-023-00910-w,https://pubmed.ncbi.nlm.nih.gov/37129799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF677,ENSG00000197928,Unsafe,35678231,ZNF677 suppresses renal cell carcinoma progression through N6-methyladenosine and transcriptional repression of CDKN3.,2022,10.1002/ctm2.906,https://pubmed.ncbi.nlm.nih.gov/35678231/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF677,ENSG00000197928,Unsafe,34785764,Loss of ZNF677 expression is a predictive biomarker for lymph node metastasis in Middle Eastern Colorectal Cancer.,2021,10.1038/s41598-021-01869-0,https://pubmed.ncbi.nlm.nih.gov/34785764/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF677,ENSG00000197928,Unsafe,34360599,Loss of ZNF677 Expression Is an Independent Predictor for Distant Metastasis in Middle Eastern Papillary Thyroid Carcinoma Patients.,2021,10.3390/ijms22157833,https://pubmed.ncbi.nlm.nih.gov/34360599/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF677,ENSG00000197928,Unsafe,34689221,Clinical significance of novel DNA methylation biomarkers for renal clear cell carcinoma.,2022,10.1007/s00432-021-03837-7,https://pubmed.ncbi.nlm.nih.gov/34689221/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF677,ENSG00000197928,Unsafe,34171355,ZNF677 downregulation by promoter hypermethylation as a driver event through gastric tumorigenesis.,2021,10.1016/j.yexmp.2021.104663,https://pubmed.ncbi.nlm.nih.gov/34171355/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF677,ENSG00000197928,Unsafe,36555747,Urine Molecular Biomarkers for Detection and Follow-Up of Small Renal Masses.,2022,10.3390/ijms232416110,https://pubmed.ncbi.nlm.nih.gov/36555747/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF677,ENSG00000197928,Unsafe,35646080,Identifying and Exploring the Candidate Susceptibility Genes of Cirrhosis Using the Multi-Tissue Transcriptome-Wide Association Study.,2022,10.3389/fgene.2022.878607,https://pubmed.ncbi.nlm.nih.gov/35646080/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF677,ENSG00000197928,Unsafe,29997231,ZNF677 Suppresses Akt Phosphorylation and Tumorigenesis in Thyroid Cancer.,2018,10.1158/0008-5472.can-18-0003,https://pubmed.ncbi.nlm.nih.gov/29997231/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF677,ENSG00000197928,Unsafe,31937794,Exploring the Novel Susceptibility Gene Variants for Primary Open-Angle Glaucoma in East Asian Cohorts: The GLAU-GENDISK Study.,2020,10.1038/s41598-019-57066-7,https://pubmed.ncbi.nlm.nih.gov/31937794/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF677,ENSG00000197928,Unsafe,32155325,Identification of hub methylated-CpG sites and associated genes in oral squamous cell carcinoma.,2020,10.1002/cam4.2969,https://pubmed.ncbi.nlm.nih.gov/32155325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF677,ENSG00000197928,Unsafe,25504438,DNA methylation transcriptionally regulates the putative tumor cell growth suppressor ZNF677 in non-small cell lung cancers.,2015,10.18632/oncotarget.2697,https://pubmed.ncbi.nlm.nih.gov/25504438/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF677,ENSG00000197928,Unsafe,34778269,Targeted Bisulfite Sequencing Reveals DNA Methylation Changes in Zinc Finger Family Genes Associated With KRAS Mutated Colorectal Cancer.,2021,10.3389/fcell.2021.759813,https://pubmed.ncbi.nlm.nih.gov/34778269/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF677,ENSG00000197928,Unsafe,33552145,A Novel Prognostic Model of Early-Stage Lung Adenocarcinoma Integrating Methylation and Immune Biomarkers.,2020,10.3389/fgene.2020.634634,https://pubmed.ncbi.nlm.nih.gov/33552145/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF677,ENSG00000197928,Unsafe,23451178,Distinct genomic aberrations between low-grade and high-grade gliomas of Chinese patients.,2013,10.1371/journal.pone.0057168,https://pubmed.ncbi.nlm.nih.gov/23451178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF678,ENSG00000181450,Unsafe,37955025,Comprehensive Analysis of a Competing Endogenous RNA Co-Expression Network in Chronic Obstructive Pulmonary Disease.,2023,10.2147/copd.s431041,https://pubmed.ncbi.nlm.nih.gov/37955025/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF678,ENSG00000181450,Unsafe,38184627,Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension.,2024,10.1038/s41467-023-44683-0,https://pubmed.ncbi.nlm.nih.gov/38184627/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF681,ENSG00000196172,Unsafe,38958676,Emergence of the ZNF675 Gene During Primate Evolution-Influenced Human Neurodevelopment Through Changing HES1 Autoregulation.,2024,10.1002/cne.25648,https://pubmed.ncbi.nlm.nih.gov/38958676/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF681,ENSG00000196172,Unsafe,38721139,Molecular diagnostic yield of whole-exome sequencing in Saudi autistic children with epilepsy.,2024,,https://pubmed.ncbi.nlm.nih.gov/38721139/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF681,ENSG00000196172,Unsafe,38045198,Identification and validation of 5-methylcytosine-associated genes in diffuse large B-cell lymphoma.,2023,10.1016/j.heliyon.2023.e22209,https://pubmed.ncbi.nlm.nih.gov/38045198/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,41869345,The transcription factor ZNF683 marks an exhaustion-like GZMB&lt;sup&gt;+&lt;/sup&gt;CD8&lt;sup&gt;+&lt;/sup&gt; T cell in sepsis.,2026,10.3389/fimmu.2026.1756339,https://pubmed.ncbi.nlm.nih.gov/41869345/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,42115771,Multi-omics profiling reveals tumor microenvironment characteristics linked to immunotherapy response and prognosis in non-small cell lung cancer.,2026,10.1038/s41698-026-01474-2,https://pubmed.ncbi.nlm.nih.gov/42115771/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,41565699,ZNF683&lt;sup&gt;+&lt;/sup&gt; NK cells govern chemotherapy sensitivity in advanced HPSCC via reshaping immune microenvironment.,2026,10.1038/s41467-026-68676-x,https://pubmed.ncbi.nlm.nih.gov/41565699/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,40730958,Multi-omics analysis of zinc finger protein 683 as a prognostic biomarker for immune infiltration in clear cell renal cell carcinoma.,2025,10.1186/s12885-025-14643-6,https://pubmed.ncbi.nlm.nih.gov/40730958/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,42661891,Single-cell and spatial landscape reveals impaired tertiary lymphoid structure maturation in &lt;i&gt;Helicobacter pylori&lt;/i&gt;-associated gastric cancer.,2026,10.3389/fimmu.2026.1908868,https://pubmed.ncbi.nlm.nih.gov/42661891/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,42694115,Pre-treatment T cell features and immune-milieu characteristics shape treatment-induced exhaustion and resistance to Blinatumomab in B-cell acute lymphoblastic leukemia.,2026,10.3389/fimmu.2026.1895742,https://pubmed.ncbi.nlm.nih.gov/42694115/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,42336618,A Multicellular Coordinated Network Driving Lymphovascular Space Invasion in Endometrioid Endometrial Carcinoma.,2026,10.1111/cpr.70246,https://pubmed.ncbi.nlm.nih.gov/42336618/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,42376361,"Understanding the Molecular Landscape of Alopecia Areata: Key Genes, Regulatory Networks, and Therapeutic Targets.",2026,10.1002/hsr2.72699,https://pubmed.ncbi.nlm.nih.gov/42376361/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,41301032,Epigenetic Regulation of NKT-Cell-Related Gene Signatures and Prognostic Implications in Oropharyngeal Squamous Cell Carcinoma.,2025,10.3390/cancers17223666,https://pubmed.ncbi.nlm.nih.gov/41301032/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,39872521,Proteomics and transcriptomics combined reveal specific immunological markers in autoimmune thyroid disease.,2024,10.3389/fimmu.2024.1531402,https://pubmed.ncbi.nlm.nih.gov/39872521/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,42754741,Spatiotemporal single-cell profiling reveals T cell clonal dynamics and phenotypic plasticity in human graft-versus-host disease.,2026,10.1038/s41590-026-02631-2,https://pubmed.ncbi.nlm.nih.gov/42754741/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,42263685,Single-cell profiling unveils an exhaustion trajectory of ZNF683&lt;sup&gt;hi&lt;/sup&gt; tissue-resident alveolar CD8&lt;sup&gt;+&lt;/sup&gt; T cells in checkpoint inhibitor pneumonitis.,2026,10.1016/j.medj.2026.101180,https://pubmed.ncbi.nlm.nih.gov/42263685/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,40730494,Genome Variation in Alcohol Use Disorder by Whole-Exome Sequencing.,2025,10.1111/adb.70070,https://pubmed.ncbi.nlm.nih.gov/40730494/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,41195968,scRNA-Seq reveals anti-lymphoma immune responses in mogamulizumab-associated skin eruptions.,2026,10.1111/jdv.70154,https://pubmed.ncbi.nlm.nih.gov/41195968/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,42503644,Characterization of persistent HPV-specific activated T cells in head and neck squamous cell carcinoma.,2026,10.1080/2162402x.2026.2707808,https://pubmed.ncbi.nlm.nih.gov/42503644/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,38956380,Diversity of group 1 innate lymphoid cells in human tissues.,2024,10.1038/s41590-024-01885-y,https://pubmed.ncbi.nlm.nih.gov/38956380/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,41761123,Spatial atlas of gastric cancer reveals macrophage-driven stromal activation via ICAM1⁺ smooth muscle cells.,2026,10.1186/s12885-026-15647-6,https://pubmed.ncbi.nlm.nih.gov/41761123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,41624883,Decoding thymic development: a single-cell atlas of tree shrew immunity.,2025,10.3389/fimmu.2025.1689906,https://pubmed.ncbi.nlm.nih.gov/41624883/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,37738974,ZNF683 marks a CD8+ T cell population associated with anti-tumor immunity following anti-PD-1 therapy for Richter syndrome.,2023,10.1016/j.ccell.2023.08.013,https://pubmed.ncbi.nlm.nih.gov/37738974/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,42402174,Shared Genetic Risk Between Acute Pancreatitis and Metabolic Syndrome Converges on a BCAT1-Positive Fibroblast Subpopulation and MAPK14-Driven Inflammation.,2026,10.1096/fj.202601080rr,https://pubmed.ncbi.nlm.nih.gov/42402174/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,41299024,Machine learning identifies TIME subtypes linking EGFR mutations and immune states in lung adenocarcinoma.,2025,10.1038/s41746-025-02172-2,https://pubmed.ncbi.nlm.nih.gov/41299024/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,40956619,"A liver-infiltrating CD4+ Tfh1 cell response predicts HCV control, hepatitis, and seroconversion during acute infection.",2025,10.1172/jci178089,https://pubmed.ncbi.nlm.nih.gov/40956619/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,39545922,Divergent Clinical and Immunologic Outcomes Based on STK11 Co-mutation Status in Resectable KRAS-Mutant Lung Cancers Following Neoadjuvant Immune Checkpoint Blockade.,2025,10.1158/1078-0432.ccr-24-2983,https://pubmed.ncbi.nlm.nih.gov/39545922/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,37683037,Preexisting tumor-resident T cells with cytotoxic potential associate with response to neoadjuvant anti-PD-1 in head and neck cancer.,2023,10.1126/sciimmunol.adf4968,https://pubmed.ncbi.nlm.nih.gov/37683037/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,39854478,Coordinated immune networks in leukemia bone marrow microenvironments distinguish response to cellular therapy.,2025,10.1126/sciimmunol.adr0782,https://pubmed.ncbi.nlm.nih.gov/39854478/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,40028342,Cytotoxic KLRG1+ IL-7R- effector CD8+ T cells distinguish kidney transplant recipients controlling cytomegalovirus reactivation.,2025,10.3389/fimmu.2025.1542531,https://pubmed.ncbi.nlm.nih.gov/40028342/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,39139402,TGF-β neutralization attenuates tumor residency of activated T cells to enhance systemic immunity in mice.,2024,10.1016/j.isci.2024.110520,https://pubmed.ncbi.nlm.nih.gov/39139402/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,26179882,Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans.,2015,10.1002/eji.201545650,https://pubmed.ncbi.nlm.nih.gov/26179882/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF683,ENSG00000176083,Unsafe,20921622,Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation.,2010,10.1172/jci42758,https://pubmed.ncbi.nlm.nih.gov/20921622/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF696,ENSG00000185730,Unsafe,41303609,The Emerging Role of FAM171A2 in Gynecological Malignancies: Bioinformatic Insights from UCEC and Ovarian Cancer.,2025,10.3390/ijms262211126,https://pubmed.ncbi.nlm.nih.gov/41303609/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF696,ENSG00000185730,Unsafe,34267729,Epigenetic Changes in Neonates Born to Mothers With Gestational Diabetes Mellitus May Be Associated With Neonatal Hypoglycaemia.,2021,10.3389/fendo.2021.690648,https://pubmed.ncbi.nlm.nih.gov/34267729/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF696,ENSG00000185730,Unsafe,37806621,Liver transcriptome profiles of dairy cows with different serum metabotypes.,2024,10.3168/jds.2023-23572,https://pubmed.ncbi.nlm.nih.gov/37806621/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF696,ENSG00000185730,Unsafe,38372747,Genome-wide DNA methylation analysis related to ALS patient progression and survival.,2024,10.1007/s00415-024-12222-6,https://pubmed.ncbi.nlm.nih.gov/38372747/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF696,ENSG00000185730,Unsafe,35309509,Integrated Analysis of Transcriptomic and Genomic Data Reveals Blood Biomarkers With Diagnostic and Prognostic Potential in Non-small Cell Lung Cancer.,2022,10.3389/fmolb.2022.774738,https://pubmed.ncbi.nlm.nih.gov/35309509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF696,ENSG00000185730,Unsafe,37190187,Development of a Novel Circulating Autoantibody Biomarker Panel for the Identification of Patients with 'Actionable' Pulmonary Nodules.,2023,10.3390/cancers15082259,https://pubmed.ncbi.nlm.nih.gov/37190187/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF696,ENSG00000185730,Unsafe,26722421,Amplification of chromosome 8q21-qter associated with the acquired paclitaxel resistance of nasopharyngeal carcinoma cells.,2015,,https://pubmed.ncbi.nlm.nih.gov/26722421/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF70,ENSG00000187792,Unsafe,41695344,tsRNA-Ala-3-0030 drives ovarian cancer progression by suppressing ZNF70.,2026,10.3389/fonc.2026.1738006,https://pubmed.ncbi.nlm.nih.gov/41695344/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF70,ENSG00000187792,Unsafe,42104604,Mechanism of Cucurbitacin B Targeting ZNF70/NLRP3 Axis Against Inflammation-Associated Colorectal Cancer.,2026,10.1002/ptr.70329,https://pubmed.ncbi.nlm.nih.gov/42104604/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF70,ENSG00000187792,Unsafe,41175847,Usnic acid alleviates pulmonary fibrosis in vitro and in vivo by inhibiting the ZNF70-mediated Wnt/β-catenin signaling pathway.,2025,10.1016/j.intimp.2025.115725,https://pubmed.ncbi.nlm.nih.gov/41175847/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF70,ENSG00000187792,Unsafe,40882550,Platycodin D targets ZNF70 to inhibit NLRP3 inflammasome and STAT3 signaling pathway to ameliorate colitis.,2025,10.1016/j.intimp.2025.115422,https://pubmed.ncbi.nlm.nih.gov/40882550/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF70,ENSG00000187792,Unsafe,38000525,ZNF70 regulates IL-1β secretion of macrophages to promote the proliferation of HCT116 cells via activation of NLRP3 inflammasome and STAT3 pathway in colitis-associated colorectal cancer.,2024,10.1016/j.cellsig.2023.110979,https://pubmed.ncbi.nlm.nih.gov/38000525/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF70,ENSG00000187792,Unsafe,37821882,Characterization of endoplasmic reticulum stress unveils ZNF703 as a promising target for colorectal cancer immunotherapy.,2023,10.1186/s12967-023-04547-z,https://pubmed.ncbi.nlm.nih.gov/37821882/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF70,ENSG00000187792,Unsafe,34135900,Host-Parasite Interaction of Atlantic salmon (Salmo salar) and the Ectoparasite Neoparamoeba perurans in Amoebic Gill Disease.,2021,10.3389/fimmu.2021.672700,https://pubmed.ncbi.nlm.nih.gov/34135900/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF70,ENSG00000187792,Unsafe,32053575,miRNA-574-5p downregulates ZNF70 and influences the progression of human esophageal squamous cell carcinoma through reactive oxygen species generation and MAPK pathway activation.,2020,10.1097/cad.0000000000000833,https://pubmed.ncbi.nlm.nih.gov/32053575/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF70,ENSG00000187792,Unsafe,29344113,Downregulated miRNA-1269a variant (rs73239138) decreases the susceptibility to gastric cancer via targeting ZNF70.,2017,10.3892/ol.2017.7091,https://pubmed.ncbi.nlm.nih.gov/29344113/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF70,ENSG00000187792,Unsafe,27353377,"ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression.",2016,10.1016/j.bbrc.2016.06.124,https://pubmed.ncbi.nlm.nih.gov/27353377/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF701,ENSG00000167562,Unsafe,31897186,Monitoring methylation-driven genes as prognostic biomarkers in patients with lung squamous cell cancer.,2020,10.3892/ol.2019.11163,https://pubmed.ncbi.nlm.nih.gov/31897186/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF709,ENSG00000242852,Unsafe,42068380,In silico analysis of gene expression signatures and drug repurposing associated with metastatic progression in melanoma (skin cancer).,2026,10.1007/s00210-026-05403-9,https://pubmed.ncbi.nlm.nih.gov/42068380/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF709,ENSG00000242852,Unsafe,26915821,Mice deficient in poly(C)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation.,2016,10.1101/gad.271890.115,https://pubmed.ncbi.nlm.nih.gov/26915821/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,42389072,Expanding the phenotypic Spectrum of ZNF711: Autism and epilepsy in two siblings.,2026,10.1016/j.ebr.2026.100878,https://pubmed.ncbi.nlm.nih.gov/42389072/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,42746363,Identification of Novel Co-Occurring &lt;i&gt;ZNF711&lt;/i&gt; and &lt;i&gt;SRCAP&lt;/i&gt; Variants in a Child with Neurodevelopmental Disorders Through Exome Sequencing.,2026,10.2147/tacg.s625023,https://pubmed.ncbi.nlm.nih.gov/42746363/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,41709745,The Znf711-Phf8 complex functions as a transcriptional rheostat essential for neutrophil development.,2026,10.3324/haematol.2025.300134,https://pubmed.ncbi.nlm.nih.gov/41709745/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,41656388,ZNF711 promotes enzalutamide resistance through transcriptional and epigenetic modification of the androgen receptor signaling pathway.,2026,10.1007/s00018-026-06092-6,https://pubmed.ncbi.nlm.nih.gov/41656388/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,39852778,Electroencephalographic and Epilepsy Findings in ZNF711 Variants: A Case Series of Two Siblings.,2025,10.3390/neurolint17010014,https://pubmed.ncbi.nlm.nih.gov/39852778/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,40395555,Exploration of Immune-Related Transcription Control/Regulation in Intracranial Aneurysm Through KEGG Analysis and in-vivo Validation.,2025,10.2147/jir.s506360,https://pubmed.ncbi.nlm.nih.gov/40395555/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,40020683,Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitment.,2025,10.1016/j.stemcr.2025.102422,https://pubmed.ncbi.nlm.nih.gov/40020683/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,38273654,Base editing of key residues in the BCL11A-XL-specific zinc finger domains derepresses fetal globin expression.,2024,10.1016/j.ymthe.2024.01.023,https://pubmed.ncbi.nlm.nih.gov/38273654/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,38908812,MAFF mediates PEITC-induced enhancement of sensitivity to carboplatin in ovarian cancer cell lines via activating ZNF711 transcription in vivo and invitro.,2024,10.1016/j.cbi.2024.111116,https://pubmed.ncbi.nlm.nih.gov/38908812/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,39423807,Structural insights into the DNA-binding mechanism of BCL11A: The integral role of ZnF6.,2024,10.1016/j.str.2024.09.022,https://pubmed.ncbi.nlm.nih.gov/39423807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,39180464,Formerly degenerate seventh zinc finger domain from transcription factor ZNF711 rehabilitated by experimental NMR structure.,2024,10.1002/pro.5149,https://pubmed.ncbi.nlm.nih.gov/39180464/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,32753895,Clinical Significance of ZNF711 in Human Breast Cancer.,2020,10.2147/ott.s251702,https://pubmed.ncbi.nlm.nih.gov/32753895/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,34521054,ZNF711 down-regulation promotes CISPLATIN resistance in epithelial ovarian cancer via interacting with JHDM2A and suppressing SLC31A1 expression.,2021,10.1016/j.ebiom.2021.103558,https://pubmed.ncbi.nlm.nih.gov/34521054/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,34992252,Clinical findings and a DNA methylation signature in kindreds with alterations in ZNF711.,2022,10.1038/s41431-021-01018-1,https://pubmed.ncbi.nlm.nih.gov/34992252/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,34356104,Analysis of a Set of KDM5C Regulatory Genes Mutated in Neurodevelopmental Disorders Identifies Temporal Coexpression Brain Signatures.,2021,10.3390/genes12071088,https://pubmed.ncbi.nlm.nih.gov/34356104/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,32406922,Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.,2020,10.1093/nar/gkaa384,https://pubmed.ncbi.nlm.nih.gov/32406922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,36076300,Construction of the coexpression network involved in the pathogenesis of thyroid eye disease via bioinformatics analysis.,2022,10.1186/s40246-022-00412-0,https://pubmed.ncbi.nlm.nih.gov/36076300/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,31691806,Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.,2019,10.1093/hmg/ddz254,https://pubmed.ncbi.nlm.nih.gov/31691806/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,27993705,Mutations in two large pedigrees highlight the role of ZNF711 in X-linked intellectual disability.,2017,10.1016/j.gene.2016.12.013,https://pubmed.ncbi.nlm.nih.gov/27993705/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,31164492,Prediction of competing endogenous RNA coexpression network as prognostic markers in AML.,2019,10.18632/aging.101985,https://pubmed.ncbi.nlm.nih.gov/31164492/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,25742136,Dysregulation of X chromosome inactivation in high grade ovarian serous adenocarcinoma.,2015,10.1371/journal.pone.0118927,https://pubmed.ncbi.nlm.nih.gov/25742136/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF711,ENSG00000147180,Unsafe,20346720,A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation.,2010,10.1016/j.molcel.2010.03.002,https://pubmed.ncbi.nlm.nih.gov/20346720/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF713,ENSG00000178665,Unsafe,40226717,Peripheral Blood Mononuclear Cell Biomarkers for Major Depressive Disorder: A Transcriptomic Approach.,2024,10.1155/2024/1089236,https://pubmed.ncbi.nlm.nih.gov/40226717/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF713,ENSG00000178665,Unsafe,41844650,Genomic modifiers of malignant and neurodevelopmental phenotypes in individuals with PTEN hamartoma tumor syndrome.,2026,10.1038/s41525-026-00556-1,https://pubmed.ncbi.nlm.nih.gov/41844650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF713,ENSG00000178665,Unsafe,34342091,Gefitinib Combined with Cetuximab for the Treatment of Lung Adenocarcinoma Harboring the EGFR-Intergenic Region (SEC61G) Fusion and EGFR Amplification.,2021,10.1002/onco.13921,https://pubmed.ncbi.nlm.nih.gov/34342091/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF713,ENSG00000178665,Unsafe,32581322,An Integrated Genomic and Transcriptomic Analysis Reveals Candidates of Susceptibility Genes for Crohn's Disease in Japanese Populations.,2020,10.1038/s41598-020-66951-5,https://pubmed.ncbi.nlm.nih.gov/32581322/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF713,ENSG00000178665,Unsafe,37277920,"Transcriptome-wide profile of 1α,25 dihydroxyvitamin D3 in HTR-8/SVneo cells.",2023,10.1111/jog.15685,https://pubmed.ncbi.nlm.nih.gov/37277920/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF713,ENSG00000178665,Unsafe,25196122,A CGG-repeat expansion mutation in ZNF713 causes FRA7A: association with autistic spectrum disorder in two families.,2014,10.1002/humu.22683,https://pubmed.ncbi.nlm.nih.gov/25196122/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF714,ENSG00000160352,Unsafe,42169128,cyberDMR: accurate and robust identification of differentially methylated regions from WGS-derived methylomes.,2026,10.1186/s12915-026-02634-3,https://pubmed.ncbi.nlm.nih.gov/42169128/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF714,ENSG00000160352,Unsafe,37958512,ZNF714 Supports Pro-Oncogenic Features in Lung Cancer Cells.,2023,10.3390/ijms242115530,https://pubmed.ncbi.nlm.nih.gov/37958512/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF714,ENSG00000160352,Unsafe,41373473,Fasting and Postprandial DNA Methylation Signatures in Adipose Tissue from Asymptomatic Individuals with Metabolic Alterations.,2025,10.3390/ijms262311306,https://pubmed.ncbi.nlm.nih.gov/41373473/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF714,ENSG00000160352,Unsafe,40564006,Effect of Recombinant Human Growth Hormone (rhGH) Use on Genetic Methylation Patterns and Their Relationship with Body Composition in Small-for-Gestational-Age (SGA) Newborns.,2025,10.3390/biomedicines13061288,https://pubmed.ncbi.nlm.nih.gov/40564006/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF714,ENSG00000160352,Unsafe,35456368,Suicide and Changes in Expression of Neuronal miRNA Predicted by an Algorithm Search through miRNA Databases.,2022,10.3390/genes13040562,https://pubmed.ncbi.nlm.nih.gov/35456368/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF714,ENSG00000160352,Unsafe,33133257,Genome-wide methylation profiles in monozygotic twins with discordance for ovarian carcinoma.,2020,10.3892/ol.2020.12221,https://pubmed.ncbi.nlm.nih.gov/33133257/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF714,ENSG00000160352,Unsafe,31103807,Genome-wide DNA methylation in suicide victims revealing impact on gene expression.,2019,10.1016/j.jad.2019.04.077,https://pubmed.ncbi.nlm.nih.gov/31103807/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF714,ENSG00000160352,Unsafe,27477082,Genome-wide DNA methylation pattern in visceral adipose tissue differentiates insulin-resistant from insulin-sensitive obese subjects.,2016,10.1016/j.trsl.2016.07.002,https://pubmed.ncbi.nlm.nih.gov/27477082/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF714,ENSG00000160352,Unsafe,29515040,A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes.,2018,10.1172/jci.insight.98212,https://pubmed.ncbi.nlm.nih.gov/29515040/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF714,ENSG00000160352,Unsafe,22750566,GWAS reveals new recessive loci associated with non-syndromic facial clefting.,2012,10.1016/j.ejmg.2012.06.005,https://pubmed.ncbi.nlm.nih.gov/22750566/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,39934654,The ZNF717-rs2918520 genotype contributes to COVID-19 severity: a Taiwanese cohort study.,2025,10.1186/s12879-025-10551-z,https://pubmed.ncbi.nlm.nih.gov/39934654/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,41618619,Bile duct tumor thrombus (intraductal polypoid growth)-positive intrahepatic cholangiocarcinoma: clinicopathologic and genomic analysis.,2026,10.1002/path.70038,https://pubmed.ncbi.nlm.nih.gov/41618619/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,39554798,The tissue and circulating cell-free DNA-derived genetic landscape of premalignant colorectal lesions and its application for early diagnosis of colorectal cancer.,2024,10.1002/mco2.70011,https://pubmed.ncbi.nlm.nih.gov/39554798/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,40880011,Integrative genomic analysis identifies clinically relevant prognostic markers for colorectal cancer patients with liver metastasis.,2026,10.1007/s12094-025-04021-w,https://pubmed.ncbi.nlm.nih.gov/40880011/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,38617633,Deciphering the Impact of Rare Missense Variants in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer through Whole Exome Sequencing: A Computational Approach.,2024,10.1021/acsomega.3c10229,https://pubmed.ncbi.nlm.nih.gov/38617633/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,37394589,Genomic characteristics of triple negative apocrine carcinoma: a comparison to triple negative breast cancer.,2023,10.1038/s12276-023-01030-z,https://pubmed.ncbi.nlm.nih.gov/37394589/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,40084286,Identification of genetic factors underlying severe retinopathy of prematurity in preterm infants.,2025,,https://pubmed.ncbi.nlm.nih.gov/40084286/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,35886052,Genomic Characterization by Whole-Exome Sequencing of Hypermobility Spectrum Disorder.,2022,10.3390/genes13071269,https://pubmed.ncbi.nlm.nih.gov/35886052/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,36735267,Integrated Whole-Exome and Transcriptome Sequencing Indicated Dysregulation of Cholesterol Metabolism in Eyelid Sebaceous Gland Carcinoma.,2023,10.1167/tvst.12.2.4,https://pubmed.ncbi.nlm.nih.gov/36735267/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,35627305,A Study of the Genomic Variations Associated with Autistic Spectrum Disorders in a Russian Cohort of Patients Using Whole-Exome Sequencing.,2022,10.3390/genes13050920,https://pubmed.ncbi.nlm.nih.gov/35627305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,34178683,Identification of Somatic Genetic Alterations Using Whole-Exome Sequencing of Uterine Leiomyosarcoma Tumors.,2021,10.3389/fonc.2021.687899,https://pubmed.ncbi.nlm.nih.gov/34178683/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,29688850,First case of AML with rare chromosome translocations: a case report of twins.,2018,10.1186/s12885-018-4396-4,https://pubmed.ncbi.nlm.nih.gov/29688850/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,31445671,Discovery of Aberrant Alteration of Genome in Colorectal Cancer by Exome Sequencing.,2019,10.1016/j.amjms.2019.07.012,https://pubmed.ncbi.nlm.nih.gov/31445671/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,30431579,"Identification of 11 potentially relevant gene mutations involved in growth retardation, intellectual disability, joint contracture, and hepatopathy.",2018,10.1097/md.0000000000013117,https://pubmed.ncbi.nlm.nih.gov/30431579/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,29327728,Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing.,2018,10.1038/cr.2018.11,https://pubmed.ncbi.nlm.nih.gov/29327728/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,29689243,Whole-exome sequencing identifies unique mutations and copy number losses in calcifying fibrous tumor of the pleura: report of 3 cases and review of the literature.,2018,10.1016/j.humpath.2018.04.005,https://pubmed.ncbi.nlm.nih.gov/29689243/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,26291246,Interplay between promoter methylation and chromosomal loss in gene silencing at 3p11-p14 in cervical cancer.,2015,10.1080/15592294.2015.1085140,https://pubmed.ncbi.nlm.nih.gov/26291246/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,32163230,Whole exome sequencing identifies multiple novel candidate genes in familial gastroschisis.,2020,10.1002/mgg3.1176,https://pubmed.ncbi.nlm.nih.gov/32163230/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,28436605,DiGeorge-like syndrome in a child with a 3p12.3 deletion involving MIR4273 gene born to a mother with gestational diabetes mellitus.,2017,10.1002/ajmg.a.38242,https://pubmed.ncbi.nlm.nih.gov/28436605/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF717,ENSG00000227124,Unsafe,25422082,Comprehensive characterization of the genomic alterations in human gastric cancer.,2015,10.1002/ijc.29352,https://pubmed.ncbi.nlm.nih.gov/25422082/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF718,ENSG00000250312,Unsafe,40211238,LncRNA-mRNA co-expression network in the mechanism of butylphthalide treatment for ischemic stroke.,2025,10.1186/s12883-025-04032-8,https://pubmed.ncbi.nlm.nih.gov/40211238/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF718,ENSG00000250312,Unsafe,38129291,Serum DNA methylome of the colorectal cancer serrated pathway enables non-invasive detection.,2024,10.1002/1878-0261.13573,https://pubmed.ncbi.nlm.nih.gov/38129291/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF718,ENSG00000250312,Unsafe,38015635,Whole-genome methylation profiling reveals regions associated with painful temporomandibular disorders and active recovery processes.,2024,10.1097/j.pain.0000000000003104,https://pubmed.ncbi.nlm.nih.gov/38015635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF718,ENSG00000250312,Unsafe,33660869,"ZNF718, HOXA4, and ZFP57 are differentially methylated in periodontitis in comparison with periodontal health: Epigenome-wide DNA methylation pilot study.",2021,10.1111/jre.12868,https://pubmed.ncbi.nlm.nih.gov/33660869/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF718,ENSG00000250312,Unsafe,32873781,Identification of de novo mutations in prenatal neurodevelopment-associated genes in schizophrenia in two Han Chinese patient-sibling family-based cohorts.,2020,10.1038/s41398-020-00987-z,https://pubmed.ncbi.nlm.nih.gov/32873781/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF718,ENSG00000250312,Unsafe,30547757,Associations of sex hormone-binding globulin and testosterone with genome-wide DNA methylation.,2018,10.1186/s12863-018-0703-y,https://pubmed.ncbi.nlm.nih.gov/30547757/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF718,ENSG00000250312,Unsafe,25288825,Epigenome variation in severe asthma.,2015,10.1177/1099800414553463,https://pubmed.ncbi.nlm.nih.gov/25288825/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF749,ENSG00000186230,Unsafe,38403804,Genetic profiling of azoospermic men to identify the etiology and predict reproductive potential.,2024,10.1007/s10815-024-03045-5,https://pubmed.ncbi.nlm.nih.gov/38403804/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF763,ENSG00000197054,Unsafe,31915063,DNA methylation changes in Down syndrome derived neural iPSCs uncover co-dysregulation of ZNF and HOX3 families of transcription factors.,2020,10.1186/s13148-019-0803-1,https://pubmed.ncbi.nlm.nih.gov/31915063/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF765,ENSG00000196417,Unsafe,37400985,"ZNF765 is a prognostic biomarker of hepatocellular carcinoma associated with cell cycle, immune infiltration, m6A modification, and drug susceptibility.",2023,10.18632/aging.204827,https://pubmed.ncbi.nlm.nih.gov/37400985/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF765,ENSG00000196417,Unsafe,38891944,Structural Variants and Implicated Processes Associated with Familial Tourette Syndrome.,2024,10.3390/ijms25115758,https://pubmed.ncbi.nlm.nih.gov/38891944/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF765,ENSG00000196417,Unsafe,32713259,IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour barrier permeability by negatively regulating ZNF765 by STAU1-mediated mRNA decay.,2020,10.1080/15476286.2020.1795583,https://pubmed.ncbi.nlm.nih.gov/32713259/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF765,ENSG00000196417,Unsafe,32887565,Whole exome sequencing highlights variants in association with Keratoconus in Jordanian families.,2020,10.1186/s12881-020-01112-z,https://pubmed.ncbi.nlm.nih.gov/32887565/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF765,ENSG00000196417,Unsafe,25401301,Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes.,2015,10.1038/ng.3146,https://pubmed.ncbi.nlm.nih.gov/25401301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF774,ENSG00000196391,Unsafe,41751509,Narrow Versus Broad Phenotype Definitions Affect Genetic Analysis of Language More than Other Broad Autism Phenotype Traits.,2026,10.3390/genes17020125,https://pubmed.ncbi.nlm.nih.gov/41751509/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF774,ENSG00000196391,Unsafe,42387537,Improved prognostic survival models for pediatric medulloblastoma using high dimensional gene expression data.,2026,10.1186/s12920-026-02418-2,https://pubmed.ncbi.nlm.nih.gov/42387537/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF774,ENSG00000196391,Unsafe,31659254,ZNF774 is a potent suppressor of hepatocarcinogenesis through dampening the NOTCH2 signaling.,2020,10.1038/s41388-019-1075-0,https://pubmed.ncbi.nlm.nih.gov/31659254/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF778,ENSG00000170100,Unsafe,40595275,Rare genetic variants and severe COVID-19 in previously healthy admixed Latin American adults.,2025,10.1038/s41598-025-08416-1,https://pubmed.ncbi.nlm.nih.gov/40595275/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF778,ENSG00000170100,Unsafe,28422132,Haploinsufficiency for ANKRD11-flanking genes makes the difference between KBG and 16q24.3 microdeletion syndromes: 12 new cases.,2017,10.1038/ejhg.2017.49,https://pubmed.ncbi.nlm.nih.gov/28422132/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF778,ENSG00000170100,Unsafe,19920853,Identification of ANKRD11 and ZNF778 as candidate genes for autism and variable cognitive impairment in the novel 16q24.3 microdeletion syndrome.,2010,10.1038/ejhg.2009.192,https://pubmed.ncbi.nlm.nih.gov/19920853/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF782,ENSG00000196597,Unsafe,35228681,Genome-wide linkage analysis combined with genome sequencing in large families with intracranial aneurysms.,2022,10.1038/s41431-022-01059-0,https://pubmed.ncbi.nlm.nih.gov/35228681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF782,ENSG00000196597,Unsafe,31432148,Characterization of the human zinc finger nfx‑1‑type containing 1 encoding ZNFX1 gene and its response to 12‑O‑tetradecanoyl‑13‑acetate in HL‑60 cells.,2019,10.3892/ijo.2019.4860,https://pubmed.ncbi.nlm.nih.gov/31432148/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF81,ENSG00000197779,Unsafe,39081929,Do extracellular vesicles have specific target cells?; Extracellular vesicle mediated embryo maternal communication.,2024,10.3389/fmolb.2024.1415909,https://pubmed.ncbi.nlm.nih.gov/39081929/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF81,ENSG00000197779,Unsafe,34048924,Comprehensive analysis of ceRNA networks in HPV16- and HPV18-mediated cervical cancers reveals XIST as a pivotal competing endogenous RNA.,2021,10.1016/j.bbadis.2021.166172,https://pubmed.ncbi.nlm.nih.gov/34048924/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF81,ENSG00000197779,Unsafe,31727082,Specific trophoblast transcripts transferred by extracellular vesicles affect gene expression in endometrial epithelial cells and may have a role in embryo-maternal crosstalk.,2019,10.1186/s12964-019-0448-x,https://pubmed.ncbi.nlm.nih.gov/31727082/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF81,ENSG00000197779,Unsafe,30559312,Whole-genome sequencing in a family with twin boys with autism and intellectual disability suggests multimodal polygenic risk.,2018,10.1101/mcs.a003285,https://pubmed.ncbi.nlm.nih.gov/30559312/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF81,ENSG00000197779,Unsafe,22634100,"335.4 kb microduplication in chromosome band Xp11.2p11.3 associated with developmental delay, growth retardation, autistic disorder and dysmorphic features.",2012,10.1016/j.gene.2012.05.031,https://pubmed.ncbi.nlm.nih.gov/22634100/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF81,ENSG00000197779,Unsafe,20662849,"Microduplication of Xp11.23p11.3 with effects on cognition, behavior, and craniofacial development.",2011,10.1111/j.1399-0004.2010.01496.x,https://pubmed.ncbi.nlm.nih.gov/20662849/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF81,ENSG00000197779,Unsafe,15121780,Zinc finger 81 (ZNF81) mutations associated with X-linked mental retardation.,2004,10.1136/jmg.2003.016972,https://pubmed.ncbi.nlm.nih.gov/15121780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF81,ENSG00000197779,Unsafe,23871722,XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing.,2013,10.1016/j.ajhg.2013.06.013,https://pubmed.ncbi.nlm.nih.gov/23871722/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF81,ENSG00000197779,Unsafe,16385466,ZNF674: a new kruppel-associated box-containing zinc-finger gene involved in nonsyndromic X-linked mental retardation.,2006,10.1086/500306,https://pubmed.ncbi.nlm.nih.gov/16385466/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF81,ENSG00000197779,Unsafe,20186789,Recurrent deletion of ZNF630 at Xp11.23 is not associated with mental retardation.,2010,10.1002/ajmg.a.33292,https://pubmed.ncbi.nlm.nih.gov/20186789/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF81,ENSG00000197779,Unsafe,8507979,"A novel X-linked member of the human zinc finger protein gene family: isolation, mapping, and expression.",1993,10.1007/bf00417431,https://pubmed.ncbi.nlm.nih.gov/8507979/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF81,ENSG00000197779,Unsafe,8088786,"Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1.",1994,10.1006/geno.1994.1240,https://pubmed.ncbi.nlm.nih.gov/8088786/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF81,ENSG00000197779,Unsafe,8088799,Physical mapping in a YAC contig of 11 markers on the human X chromosome in Xp11.23.,1994,10.1006/geno.1994.1255,https://pubmed.ncbi.nlm.nih.gov/8088799/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF81,ENSG00000197779,Unsafe,16506138,[Non-specific X-linked mental retardation].,2006,,https://pubmed.ncbi.nlm.nih.gov/16506138/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF81,ENSG00000197779,Unsafe,8530079,"A high-resolution map of genes, microsatellite markers, and new dinucleotide repeats from UBE1 to the GATA locus in the region Xp11.23.",1995,10.1006/geno.1995.1238,https://pubmed.ncbi.nlm.nih.gov/8530079/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF81,ENSG00000197779,Unsafe,8088827,A 1.8-Mb YAC contig in Xp11.23: identification of CpG islands and physical mapping of CA repeats in a region of high gene density.,1994,10.1006/geno.1994.1274,https://pubmed.ncbi.nlm.nih.gov/8088827/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF845,ENSG00000213799,Unsafe,40469776,Gene network changes after exposure to nanoliposomes containing antisense miR-21 and miR-373 in bladder cancer Cells: An &lt;i&gt;in vitro&lt;/i&gt; model study.,2025,10.1016/j.bbrep.2025.102041,https://pubmed.ncbi.nlm.nih.gov/40469776/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF845,ENSG00000213799,Unsafe,41283084,Decoding the Genetic Landscape of Postoperative Nausea and Vomiting in Cancer Surgery: A New Frontier in Personalized Medicine Driven by Genome-Wide Association Studies.,2025,10.1007/s13193-024-02172-w,https://pubmed.ncbi.nlm.nih.gov/41283084/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF845,ENSG00000213799,Unsafe,35500123,A novel regulatory gene promotes novel cell fate by suppressing ancestral fate in the sea anemone Nematostella vectensis.,2022,10.1073/pnas.2113701119,https://pubmed.ncbi.nlm.nih.gov/35500123/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF845,ENSG00000213799,Unsafe,27006382,Gene expression profiling in undifferentiated thyroid carcinoma induced by high-dose radiation.,2016,10.1093/jrr/rrw002,https://pubmed.ncbi.nlm.nih.gov/27006382/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF845,ENSG00000213799,Unsafe,29206233,Genome-wide admixture and association study of subclinical atherosclerosis in the Women's Interagency HIV Study (WIHS).,2017,10.1371/journal.pone.0188725,https://pubmed.ncbi.nlm.nih.gov/29206233/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF85,ENSG00000105750,Unsafe,9839802,"Functional analysis of ZNF85 KRAB zinc finger protein, a member of the highly homologous ZNF91 family.",1998,10.1089/dna.1998.17.931,https://pubmed.ncbi.nlm.nih.gov/9839802/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF85,ENSG00000105750,Unsafe,22701369,Correlation of dynamic PET and gene array data in patients with gastrointestinal stromal tumors.,2012,10.1100/2012/721313,https://pubmed.ncbi.nlm.nih.gov/22701369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF85,ENSG00000105750,Unsafe,2023909,The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.,1991,10.1073/pnas.88.9.3608,https://pubmed.ncbi.nlm.nih.gov/2023909/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF93,ENSG00000184635,Unsafe,40828019,Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B.,2025,10.1073/pnas.2505021122,https://pubmed.ncbi.nlm.nih.gov/40828019/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF93,ENSG00000184635,Unsafe,39501301,Integrative analysis based on ATAC-seq and RNA-seq reveals a novel oncogene PRPF3 in hepatocellular carcinoma.,2024,10.1186/s13148-024-01769-w,https://pubmed.ncbi.nlm.nih.gov/39501301/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF93,ENSG00000184635,Unsafe,40384846,LncRNA OIP5-AS1 promotes immune evasion in abdominal aortic aneurysm cells by recruiting MDSCs and inhibiting CD8 + T cells through STK24 upregulation.,2025,10.1007/s10616-025-00767-x,https://pubmed.ncbi.nlm.nih.gov/40384846/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF93,ENSG00000184635,Unsafe,32509065,High expression of ZNF93 promotes proliferation and migration of ovarian cancer cells and relates to poor prognosis.,2020,,https://pubmed.ncbi.nlm.nih.gov/32509065/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF93,ENSG00000184635,Unsafe,36341546,Structure and functional mapping of the KRAB-KAP1 repressor complex.,2022,10.15252/embj.2022111179,https://pubmed.ncbi.nlm.nih.gov/36341546/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF93,ENSG00000184635,Unsafe,19742314,ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines.,2009,10.1371/journal.pone.0006967,https://pubmed.ncbi.nlm.nih.gov/19742314/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF93,ENSG00000184635,Unsafe,25274305,An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons.,2014,10.1038/nature13760,https://pubmed.ncbi.nlm.nih.gov/25274305/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF93,ENSG00000184635,Unsafe,29981437,Rare Variants in Known Susceptibility Loci and Their Contribution to Risk of Lung Cancer.,2018,10.1016/j.jtho.2018.06.016,https://pubmed.ncbi.nlm.nih.gov/29981437/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF93,ENSG00000184635,Unsafe,30070359,Discovery and development of differentially methylated regions in human papillomavirus-related oropharyngeal squamous cell carcinoma.,2018,10.1002/ijc.31778,https://pubmed.ncbi.nlm.nih.gov/30070359/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF93,ENSG00000184635,Unsafe,27998939,A pipeline for local assembly of minisatellite alleles from single-molecule sequencing data.,2017,10.1093/bioinformatics/btw687,https://pubmed.ncbi.nlm.nih.gov/27998939/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNF98,ENSG00000197360,Unsafe,26179511,Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma.,2015,10.1158/1078-0432.ccr-14-2744,https://pubmed.ncbi.nlm.nih.gov/26179511/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNG1A,ENSG00000172785,Unsafe,38818040,Identifying potential drug targets for varicose veins through integration of GWAS and eQTL summary data.,2024,10.3389/fgene.2024.1385293,https://pubmed.ncbi.nlm.nih.gov/38818040/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNG1A,ENSG00000172785,Unsafe,41137173,Whole-genome sequencing reveals individual and cohort level insights into chromosome 9p syndromes.,2025,10.1186/s13073-025-01563-0,https://pubmed.ncbi.nlm.nih.gov/41137173/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNG1A,ENSG00000172785,Unsafe,42556472,An Integrative Morphological and Genomic Analysis With a Refined Fluorescence In Situ Hybridization (FISH) Threshold and Novel Kinase Fusions in a Large Asian Cohort of Spitzoid Neoplasms.,2026,10.1016/j.modpat.2026.101058,https://pubmed.ncbi.nlm.nih.gov/42556472/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNG1A,ENSG00000172785,Unsafe,38566210,Leveraging new methods for comprehensive characterization of mitochondrial DNA in esophageal squamous cell carcinoma.,2024,10.1186/s13073-024-01319-2,https://pubmed.ncbi.nlm.nih.gov/38566210/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNG1A,ENSG00000172785,Unsafe,31862704,Deletion in the Cobalamin Synthetase W Domain-Containing Protein 1 Gene Is associated with Congenital Anomalies of the Kidney and Urinary Tract.,2020,10.1681/asn.2019040398,https://pubmed.ncbi.nlm.nih.gov/31862704/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNG1A,ENSG00000172785,Unsafe,35180297,Genetic pleiotropy between pulmonary function and age-related traits: The Long Life Family Study.,2022,10.1093/gerona/glac046,https://pubmed.ncbi.nlm.nih.gov/35180297/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNG1A,ENSG00000172785,Unsafe,35910780,Icariin and Competing Endogenous RNA Network: A Potential Protective Strategy Against Contrast-Induced Acute Kidney Injury.,2022,10.2147/dddt.s369100,https://pubmed.ncbi.nlm.nih.gov/35910780/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNG1A,ENSG00000172785,Unsafe,36003381,A novel tumor mutational burden-based risk model predicts prognosis and correlates with immune infiltration in ovarian cancer.,2022,10.3389/fimmu.2022.943389,https://pubmed.ncbi.nlm.nih.gov/36003381/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNG1A,ENSG00000172785,Unsafe,31887331,Identification of key HIF-1α target genes that regulate adaptation to hypoxic conditions in Tibetan chicken embryos.,2020,10.1016/j.gene.2019.144321,https://pubmed.ncbi.nlm.nih.gov/31887331/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNG1A,ENSG00000172785,Unsafe,30333196,Cell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes.,2018,10.1101/gr.233304.117,https://pubmed.ncbi.nlm.nih.gov/30333196/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNG1A,ENSG00000172785,Unsafe,15233989,Diverse fates of paralogs following segmental duplication of telomeric genes.,2004,10.1016/j.ygeno.2004.03.001,https://pubmed.ncbi.nlm.nih.gov/15233989/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNG1F,ENSG00000215126,Unsafe,40886963,Adipose Tissue Macrophage-Derived Proplatelet Basic Protein Exacerbates Psoriasis-Associated Atherosclerosis by Inducing Mitochondrial Dysfunction in Aortic Endothelial Cells.,2026,10.1016/j.jid.2025.05.041,https://pubmed.ncbi.nlm.nih.gov/40886963/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNG1F,ENSG00000215126,Unsafe,41264133,Non-WNT/non-SHH medulloblastoma in siblings: case report and literature review.,2025,10.1007/s12672-025-04038-1,https://pubmed.ncbi.nlm.nih.gov/41264133/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNG1F,ENSG00000215126,Unsafe,39629711,Identification of Genetic Factors Related With Nonhereditary Colorectal Polyposis and Its Recurrence Through Genome-Wide Association Study.,2025,10.1111/jgh.16840,https://pubmed.ncbi.nlm.nih.gov/39629711/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZNG1F,ENSG00000215126,Unsafe,34441376,Aberrant Whole Blood Gene Expression in the Lumen of Human Intracranial Aneurysms.,2021,10.3390/diagnostics11081442,https://pubmed.ncbi.nlm.nih.gov/34441376/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,42920325,A Novel Homozygous ZPBP Frameshift Variant Is Associated With Severe Acrosomal Structural Abnormalities in Asthenoteratozoospermia.,2026,10.1111/andr.70395,https://pubmed.ncbi.nlm.nih.gov/42920325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,41654813,Protein disulfide isomerase A6 (PDIA6) is essential for acrosome biogenesis and male fertility in mice.,2026,10.1186/s12964-026-02709-2,https://pubmed.ncbi.nlm.nih.gov/41654813/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,41124178,ZPBP and fertility-associated proteomes as novel biomarkers: A shotgun proteomics approach in Murrah buffalo (Bubalus bubalis) bulls' seminal plasma and cryopreserved spermatozoa.,2025,10.1371/journal.pone.0333272,https://pubmed.ncbi.nlm.nih.gov/41124178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,42003384,Protective effect of Rosmarinus officinalis L. extract against cyclophosphamide-induced testicular toxicity in rats.,2026,10.5653/cerm.2025.08606,https://pubmed.ncbi.nlm.nih.gov/42003384/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,41668650,Actin-related protein T3 is required for acrosome biogenesis and sperm function in mice.,2026,10.1242/dev.205283,https://pubmed.ncbi.nlm.nih.gov/41668650/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,38421455,"Spem2, a novel testis-enriched gene, is required for spermiogenesis and fertilization in mice.",2024,10.1007/s00018-024-05147-w,https://pubmed.ncbi.nlm.nih.gov/38421455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,39417902,Genetic etiological spectrum of sperm morphological abnormalities.,2024,10.1007/s10815-024-03274-8,https://pubmed.ncbi.nlm.nih.gov/39417902/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,40276155,Proteomic analysis of Toraya buffalo seminal plasma and sperm: uncovering insights to optimize reproductive success.,2025,10.3389/fvets.2025.1492135,https://pubmed.ncbi.nlm.nih.gov/40276155/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,38847481,Male infertility and perfluoroalkyl and poly-fluoroalkyl substances: evidence for alterations in phosphorylation of proteins and fertility-related functional attributes in bull spermatozoa†.,2024,10.1093/biolre/ioae089,https://pubmed.ncbi.nlm.nih.gov/38847481/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,37118964,Differential Proteomic Analysis of Human Sperm: A Systematic Review to Identify Candidate Targets to Monitor Sperm Quality.,2024,10.5534/wjmh.220262,https://pubmed.ncbi.nlm.nih.gov/37118964/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,36980830,Effect of Dietetic Obesity on Testicular Transcriptome in Cynomolgus Monkeys.,2023,10.3390/genes14030557,https://pubmed.ncbi.nlm.nih.gov/36980830/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,35751016,Ectopic expression of a combination of 5 genes detects high risk forms of T-cell acute lymphoblastic leukemia.,2022,10.1186/s12864-022-08688-1,https://pubmed.ncbi.nlm.nih.gov/35751016/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,35145544,Identification of Key Genes Related to Postnatal Testicular Development Based on Transcriptomic Data of Testis in Hu Sheep.,2021,10.3389/fgene.2021.773695,https://pubmed.ncbi.nlm.nih.gov/35145544/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,37046330,New insights into posttranslational modifications of proteins during bull sperm capacitation.,2023,10.1186/s12964-023-01080-w,https://pubmed.ncbi.nlm.nih.gov/37046330/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,31985809,Exome sequencing reveals novel causes as well as new candidate genes for human globozoospermia.,2020,10.1093/humrep/dez246,https://pubmed.ncbi.nlm.nih.gov/31985809/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,35863763,Testis-specific serine protease PRSS54 regulates acrosomal granule localization and sperm head morphogenesis in mice†.,2022,10.1093/biolre/ioac146,https://pubmed.ncbi.nlm.nih.gov/35863763/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,35921706,Actl7a deficiency in mice leads to male infertility and fertilization failure.,2022,10.1016/j.bbrc.2022.07.065,https://pubmed.ncbi.nlm.nih.gov/35921706/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,32679808,Low-Dose Radiation Exposure with 56MnO2 Powder Changes Gene Expressions in the Testes and the Prostate in Rats.,2020,10.3390/ijms21144989,https://pubmed.ncbi.nlm.nih.gov/32679808/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,31333723,Analysis of Long Non-Coding RNA and mRNA Expression Profiling in Immature and Mature Bovine (Bos taurus) Testes.,2019,10.3389/fgene.2019.00646,https://pubmed.ncbi.nlm.nih.gov/31333723/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,31807615,Hypomethylation in the promoter region of ZPBP as a potential litter size indicator in Berkshire pigs.,2019,10.5194/aab-62-69-2019,https://pubmed.ncbi.nlm.nih.gov/31807615/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,42752660,Characterization of DPYD pharmacogenetic variation in Mexican patients with gastrointestinal malignancies.,2026,10.1007/s00280-026-04955-0,https://pubmed.ncbi.nlm.nih.gov/42752660/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,31509916,"Fluoride exposure arrests the acrosome formation during spermatogenesis via down-regulated Zpbp1, Spaca1 and Dpy19l2 expression in rat testes.",2019,10.1016/j.chemosphere.2019.04.019,https://pubmed.ncbi.nlm.nih.gov/31509916/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,32724789,Genome-Wide Identification and Analysis of Variants in Domestic and Wild Bactrian Camels Using Whole-Genome Sequencing Data.,2020,10.1155/2020/2430846,https://pubmed.ncbi.nlm.nih.gov/32724789/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,31313401,Targeting cholecystokinin-2 receptor for pancreatic cancer chemoprevention.,2019,10.1002/mc.23084,https://pubmed.ncbi.nlm.nih.gov/31313401/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,31666004,Weighted single-step GWAS identified candidate genes associated with semen traits in a Duroc boar population.,2019,10.1186/s12864-019-6164-5,https://pubmed.ncbi.nlm.nih.gov/31666004/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZPBP,ENSG00000042813,Unsafe,17664285,Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis.,2007,10.1128/mcb.01029-07,https://pubmed.ncbi.nlm.nih.gov/17664285/,annotation citations,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,42510787,Identification and Preliminary Clinical Assessment of Key Genes Related to Endoplasmic Reticulum Stress and Autophagy in Minimal Change Disease.,2026,10.3390/genes17070747,https://pubmed.ncbi.nlm.nih.gov/42510787/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,41596226,The Zinc Finger Ran-Binding Protein 3 (ZRANB3): An Advanced Perspective.,2026,10.3390/ijms27020574,https://pubmed.ncbi.nlm.nih.gov/41596226/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,41587991,Structural basis for fork reversal and RAD51 regulation by the SCF ubiquitin ligase complex of F-box helicase 1.,2026,10.1038/s41467-026-68752-2,https://pubmed.ncbi.nlm.nih.gov/41587991/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,39044358,"DNA fork remodeling proteins, Zranb3 and Smarcal1, are uniquely essential for aging hematopoiesis.",2024,10.1111/acel.14281,https://pubmed.ncbi.nlm.nih.gov/39044358/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,41099703,Distinct roles of RECQL5 in RAD51-mediated fork reversal and transcription elongation.,2025,10.1093/nar/gkaf1019,https://pubmed.ncbi.nlm.nih.gov/41099703/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,38917325,MRNIP limits ssDNA gaps during replication stress.,2024,10.1093/nar/gkae546,https://pubmed.ncbi.nlm.nih.gov/38917325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,40495033,RNF20-mediated H2B monoubiquitination protects stalled forks from degradation and promotes fork restart.,2025,10.1038/s44319-025-00497-3,https://pubmed.ncbi.nlm.nih.gov/40495033/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,37036693,RFWD3 promotes ZRANB3 recruitment to regulate the remodeling of stalled replication forks.,2023,10.1083/jcb.202106022,https://pubmed.ncbi.nlm.nih.gov/37036693/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,38321962,The levels of p53 govern the hierarchy of DNA damage tolerance pathway usage.,2024,10.1093/nar/gkae061,https://pubmed.ncbi.nlm.nih.gov/38321962/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,37372369,Methylation Levels in the Promoter Region of FHIT and PIAS1 Genes Associated with Mastitis Resistance in Xinjiang Brown Cattle.,2023,10.3390/genes14061189,https://pubmed.ncbi.nlm.nih.gov/37372369/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,35801922,Strand annealing and motor driven activities of SMARCAL1 and ZRANB3 are stimulated by RAD51 and the paralog complex.,2022,10.1093/nar/gkac583,https://pubmed.ncbi.nlm.nih.gov/35801922/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,39116203,RTEL1 helicase counteracts RAD51-mediated homologous recombination and fork reversal to safeguard replicating genomes.,2024,10.1016/j.celrep.2024.114594,https://pubmed.ncbi.nlm.nih.gov/39116203/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,39089193,Mechanisms and regulation of replication fork reversal.,2024,10.1016/j.dnarep.2024.103731,https://pubmed.ncbi.nlm.nih.gov/39089193/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,33523105,"Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets.",2021,10.1001/jamaneurol.2020.5257,https://pubmed.ncbi.nlm.nih.gov/33523105/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,37058556,Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability.,2023,10.1126/sciadv.ade7997,https://pubmed.ncbi.nlm.nih.gov/37058556/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,31836351,Clofarabine Commandeers the RNR-α-ZRANB3 Nuclear Signaling Axis.,2020,10.1016/j.chembiol.2019.11.012,https://pubmed.ncbi.nlm.nih.gov/31836351/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,31324766,ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response.,2019,10.1038/s41467-019-10967-7,https://pubmed.ncbi.nlm.nih.gov/31324766/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,30150681,Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3.,2018,10.1038/s41589-018-0113-5,https://pubmed.ncbi.nlm.nih.gov/30150681/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,34165573,"Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices.",2021,10.1093/nar/gkab526,https://pubmed.ncbi.nlm.nih.gov/34165573/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,35353580,CHK1 phosphorylates PRIMPOL to promote replication stress tolerance.,2022,10.1126/sciadv.abm0314,https://pubmed.ncbi.nlm.nih.gov/35353580/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,30610086,Smarcal1 and Zranb3 Protect Replication Forks from Myc-Induced DNA Replication Stress.,2019,10.1158/0008-5472.can-18-2705,https://pubmed.ncbi.nlm.nih.gov/30610086/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,32971328,Time for remodeling: SNF2-family DNA translocases in replication fork metabolism and human disease.,2020,10.1016/j.dnarep.2020.102943,https://pubmed.ncbi.nlm.nih.gov/32971328/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,28621305,Structural insights into the function of ZRANB3 in replication stress response.,2017,10.1038/ncomms15847,https://pubmed.ncbi.nlm.nih.gov/28621305/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZRANB3,ENSG00000121988,Unsafe,30184498,ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links.,2018,10.1016/j.celrep.2018.08.019,https://pubmed.ncbi.nlm.nih.gov/30184498/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN20,ENSG00000121903,Unsafe,41639465,Atlas-guided discovery of transcription factors for T cell programming.,2026,10.1038/s41586-025-09989-7,https://pubmed.ncbi.nlm.nih.gov/41639465/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN20,ENSG00000121903,Unsafe,36462500,"Comprehensive analysis of prognostic value, relationship to cell cycle, immune infiltration and m6A modification of ZSCAN20 in hepatocellular carcinoma.",2022,10.18632/aging.204312,https://pubmed.ncbi.nlm.nih.gov/36462500/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN20,ENSG00000121903,Unsafe,37120803,"Correction for: Comprehensive analysis of prognostic value, relationship to cell cycle, immune infiltration and m6A modification of ZSCAN20 in hepatocellular carcinoma.",2023,10.18632/aging.204699,https://pubmed.ncbi.nlm.nih.gov/37120803/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN20,ENSG00000121903,Unsafe,38515383,ZNF263 cooperates with ZNF31 to promote the drug resistance and EMT of pancreatic cancer through transactivating RNF126.,2024,10.1002/jcp.31259,https://pubmed.ncbi.nlm.nih.gov/38515383/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN20,ENSG00000121903,Unsafe,40255485,Transcriptomic signature can distinguish chronic neutrophilic leukemia from ambiguous neutrophilic leukemias.,2025,10.3389/fgene.2025.1556519,https://pubmed.ncbi.nlm.nih.gov/40255485/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN20,ENSG00000121903,Unsafe,38747976,Brugada syndrome in Japan and Europe: a genome-wide association study reveals shared genetic architecture and new risk loci.,2024,10.1093/eurheartj/ehae251,https://pubmed.ncbi.nlm.nih.gov/38747976/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN20,ENSG00000121903,Unsafe,33550903,A Novel 10-Gene Signature Predicts Poor Prognosis in Low Grade Glioma.,2021,10.1177/1533033821992084,https://pubmed.ncbi.nlm.nih.gov/33550903/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN20,ENSG00000121903,Unsafe,32884031,Genome-wide association study for circulating fibroblast growth factor 21 and 23.,2020,10.1038/s41598-020-71569-8,https://pubmed.ncbi.nlm.nih.gov/32884031/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN23,ENSG00000187987,Unsafe,41952686,Novel transcriptomic alterations in poorly differentiated endometrial carcinomas: evidence from South African women.,2026,10.3389/fonc.2026.1694662,https://pubmed.ncbi.nlm.nih.gov/41952686/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN23,ENSG00000187987,Unsafe,38226836,Epigenetic silencing ZSCAN23 promotes pancreatic cancer growth by activating Wnt signaling.,2024,10.1080/15384047.2024.2302924,https://pubmed.ncbi.nlm.nih.gov/38226836/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN23,ENSG00000187987,Unsafe,40021682,Rare genetic associations with human lifespan in UK Biobank are enriched for oncogenic genes.,2025,10.1038/s41467-025-57315-6,https://pubmed.ncbi.nlm.nih.gov/40021682/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN23,ENSG00000187987,Unsafe,41733899,Shared Genetic Basis and Causality Between Epilepsy and Psychiatric Disorders: Evidence From a Comprehensive Genetic Analysis.,2026,10.1002/brb3.71267,https://pubmed.ncbi.nlm.nih.gov/41733899/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN23,ENSG00000187987,Unsafe,39060982,Detection and evaluation of parameters influencing the identification of heterozygous-enriched regions in Holstein cattle based on SNP chip or whole-genome sequence data.,2024,10.1186/s12864-024-10642-2,https://pubmed.ncbi.nlm.nih.gov/39060982/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN23,ENSG00000187987,Unsafe,34056873,Prognostic biomarker identification and tumor classification in breast cancer patients by methylation and transcriptome analysis.,2021,10.1002/2211-5463.13211,https://pubmed.ncbi.nlm.nih.gov/34056873/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN23,ENSG00000187987,Unsafe,35858526,Associations between antenatal maternal asthma status and placental DNA methylation.,2022,10.1016/j.placenta.2022.06.008,https://pubmed.ncbi.nlm.nih.gov/35858526/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN23,ENSG00000187987,Unsafe,21682861,Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving.,2011,10.1186/1471-2148-11-171,https://pubmed.ncbi.nlm.nih.gov/21682861/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN5A,ENSG00000131848,Unsafe,40348787,Medulloblastoma's master regulators and their association with patients' risk.,2025,10.1038/s41598-025-00763-3,https://pubmed.ncbi.nlm.nih.gov/40348787/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN5A,ENSG00000131848,Unsafe,27732952,ZSCAN5B and primate-specific paralogs bind RNA polymerase III genes and extra-TFIIIC (ETC) sites to modulate mitotic progression.,2016,10.18632/oncotarget.12508,https://pubmed.ncbi.nlm.nih.gov/27732952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN5A,ENSG00000131848,Unsafe,36438554,The single-cell expression profile of transposable elements and transcription factors in human early biparental and uniparental embryonic development.,2022,10.3389/fcell.2022.1020490,https://pubmed.ncbi.nlm.nih.gov/36438554/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN5A,ENSG00000131848,Unsafe,37033211,Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses.,2023,10.3389/fendo.2023.1143067,https://pubmed.ncbi.nlm.nih.gov/37033211/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN5A,ENSG00000131848,Unsafe,33162025,Five multicopy gene family genes expressed during the maternal-to-zygotic transition are not essential for mouse development.,2021,10.1016/j.bbrc.2020.11.004,https://pubmed.ncbi.nlm.nih.gov/33162025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN5B,ENSG00000197213,Unsafe,39951848,Revealing the effects of lactate on bovine SCNT embryo development through transcriptome sequencing analyses.,2025,10.1016/j.theriogenology.2025.02.007,https://pubmed.ncbi.nlm.nih.gov/39951848/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN5B,ENSG00000197213,Unsafe,34541557,Using piggyBac transposon gene expression vectors to transfect Zscan5b gene into mouse pluripotent stem cells.,2021,10.1016/j.xpro.2021.100811,https://pubmed.ncbi.nlm.nih.gov/34541557/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN5B,ENSG00000197213,Unsafe,31155506,Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis.,2019,10.1016/j.stemcr.2019.05.002,https://pubmed.ncbi.nlm.nih.gov/31155506/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN5B,ENSG00000197213,Unsafe,27732952,ZSCAN5B and primate-specific paralogs bind RNA polymerase III genes and extra-TFIIIC (ETC) sites to modulate mitotic progression.,2016,10.18632/oncotarget.12508,https://pubmed.ncbi.nlm.nih.gov/27732952/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN5B,ENSG00000197213,Unsafe,33162025,Five multicopy gene family genes expressed during the maternal-to-zygotic transition are not essential for mouse development.,2021,10.1016/j.bbrc.2020.11.004,https://pubmed.ncbi.nlm.nih.gov/33162025/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZSCAN5B,ENSG00000197213,Unsafe,33478599,Histone Demethylase KDM4D Could Improve the Developmental Competence of Buffalo (Bubalus Bubalis) Somatic Cell Nuclear Transfer (SCNT) Embryos.,2021,10.1017/s1431927620024964,https://pubmed.ncbi.nlm.nih.gov/33478599/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZXDA,ENSG00000198205,Unsafe,42884178,CD180-Associated B-Cell Alterations in Type 1 Diabetes and the In Vitro Effects of Chlorogenic Acid: An Integrated Transcriptomic and Experimental Study.,2026,10.3390/ijms27198933,https://pubmed.ncbi.nlm.nih.gov/42884178/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZXDA,ENSG00000198205,Unsafe,35813202,FBXO38 Ubiquitin Ligase Controls Centromere Integrity via ZXDA/B Stability.,2022,10.3389/fcell.2022.929288,https://pubmed.ncbi.nlm.nih.gov/35813202/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZXDA,ENSG00000198205,Unsafe,19777325,An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription.,2010,10.1007/s11010-009-0280-5,https://pubmed.ncbi.nlm.nih.gov/19777325/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZXDA,ENSG00000198205,Unsafe,17493635,The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription.,2007,10.1016/j.jmb.2007.04.033,https://pubmed.ncbi.nlm.nih.gov/17493635/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZXDA,ENSG00000198205,Unsafe,23236494,"X-linked gene transcription patterns in female and male in vivo, in vitro and cloned porcine individual blastocysts.",2012,10.1371/journal.pone.0051398,https://pubmed.ncbi.nlm.nih.gov/23236494/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZXDA,ENSG00000198205,Unsafe,20684234,[Changes in genes expression caused by overexpression of the transcription factor ZXDC in embryonic kidney cell line HEK293].,2010,,https://pubmed.ncbi.nlm.nih.gov/20684234/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZXDA,ENSG00000198205,Unsafe,17696781,Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain.,2007,10.1515/bc.2007.106,https://pubmed.ncbi.nlm.nih.gov/17696781/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZXDA,ENSG00000198205,Unsafe,11896455,"Lack of expression of XIST from a small ring X chromosome containing the XIST locus in a girl with short stature, facial dysmorphism and developmental delay.",2002,10.1038/sj.ejhg.5200757,https://pubmed.ncbi.nlm.nih.gov/11896455/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZXDA,ENSG00000198205,Unsafe,16061661,Altered ErbB receptor signaling and gene expression in cisplatin-resistant ovarian cancer.,2005,10.1158/0008-5472.can-04-2684,https://pubmed.ncbi.nlm.nih.gov/16061661/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZXDA,ENSG00000198205,Unsafe,8079992,The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation.,1994,,https://pubmed.ncbi.nlm.nih.gov/8079992/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZXDA,ENSG00000198205,Unsafe,9832041,Severe phenotype resulting from an active ring X chromosome in a female with a complex karyotype: characterisation and replication study.,1998,10.1136/jmg.35.11.932,https://pubmed.ncbi.nlm.nih.gov/9832041/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZXDA,ENSG00000198205,Unsafe,8554051,Molecular definition of breakpoints associated with human Xq isochromosomes: implications for mechanisms of formation.,1996,,https://pubmed.ncbi.nlm.nih.gov/8554051/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZXDA,ENSG00000198205,Unsafe,8268913,"Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies.",1993,10.1093/hmg/2.10.1611,https://pubmed.ncbi.nlm.nih.gov/8268913/,annotation citations | normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZYG11A,ENSG00000203995,Unsafe,40829600,Genetic analysis in African ancestry populations reveals genetic contributors to lung cancer susceptibility.,2025,10.1016/j.ajhg.2025.07.009,https://pubmed.ncbi.nlm.nih.gov/40829600/,normal | therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZYG11A,ENSG00000203995,Unsafe,34220714,ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates With Low Grade Disease.,2021,10.3389/fendo.2021.688104,https://pubmed.ncbi.nlm.nih.gov/34220714/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZYG11A,ENSG00000203995,Unsafe,39256256,Molecular age prediction using skull bone samples from individuals with and without signs of decomposition: a multivariate approach combining analysis of posttranslational protein modifications and DNA methylation.,2025,10.1007/s00414-024-03314-z,https://pubmed.ncbi.nlm.nih.gov/39256256/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZYG11A,ENSG00000203995,Unsafe,31320996,Identification of ZYG11A as a candidate IGF1-dependent proto-oncogene in endometrial cancer.,2019,10.18632/oncotarget.27055,https://pubmed.ncbi.nlm.nih.gov/31320996/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZYG11A,ENSG00000203995,Unsafe,38008592,"Network analysis of transcriptomic data uncovers molecular signatures and the interplay of mRNAs, lncRNAs, and miRNAs in human embryonic stem cells.",2024,10.1016/j.diff.2023.11.001,https://pubmed.ncbi.nlm.nih.gov/38008592/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZYG11A,ENSG00000203995,Unsafe,30899432,"DNA hypomethylation-related overexpression of SFN, GORASP2 and ZYG11A is a novel prognostic biomarker for early stage lung adenocarcinoma.",2019,10.18632/oncotarget.26676,https://pubmed.ncbi.nlm.nih.gov/30899432/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZYG11A,ENSG00000203995,Unsafe,26771237,ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression.,2016,10.18632/oncotarget.6904,https://pubmed.ncbi.nlm.nih.gov/26771237/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZYG11A,ENSG00000203995,Unsafe,27810909,The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage.,2016,10.1083/jcb.201601083,https://pubmed.ncbi.nlm.nih.gov/27810909/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZYG11A,ENSG00000203995,Unsafe,28401182,Addressing a weakness of anticancer therapy with mitosis inhibitors: Mitotic slippage.,2017,10.1080/23723556.2016.1277293,https://pubmed.ncbi.nlm.nih.gov/28401182/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZYG11A,ENSG00000203995,Unsafe,27107416,Atlas on substrate recognition subunits of CRL2 E3 ligases.,2016,10.18632/oncotarget.8732,https://pubmed.ncbi.nlm.nih.gov/27107416/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZYG11A,ENSG00000203995,Unsafe,17304241,The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components.,2007,10.1038/sj.embor.7400895,https://pubmed.ncbi.nlm.nih.gov/17304241/,normal,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"
ZYG11A,ENSG00000203995,Unsafe,27810907,Slip slidin' away of mitosis with CRL2Zyg11.,2016,10.1083/jcb.201609086,https://pubmed.ncbi.nlm.nih.gov/27810907/,therapy,"Retrieved lead; gene identity, species, assay and conclusions not adjudicated"